From 382bf8fdd9e522a34c00947a989cf0df1c5e1311 Mon Sep 17 00:00:00 2001 From: Maksym Date: Wed, 28 Feb 2024 10:30:14 -0500 Subject: [PATCH] LLMFactCheck --- data/1.csv | 3920 +++++++++++++++++++++++++--------------------------- 1 file changed, 1895 insertions(+), 2025 deletions(-) diff --git a/data/1.csv b/data/1.csv index cd43e3e..264bc65 100644 --- a/data/1.csv +++ b/data/1.csv @@ -1,2898 +1,2768 @@ Predicate ID,Triple,Sentence ID,Sentence,Is Correct,Question,Answer -24413653,Fenbendazole treats helminthiasis,1001,"This study investigated worm control practices by free-range egg farmers and the efficacy of the commercial anthelmintics levamisole (LEV), piperazine (PIP), flubendazole (FLBZ) and fenbendazole (FBZ) against gastrointestinal nematodes on two free-range layer farms in Australia.",True,"Is the triple 'Fenbendazole treats helminthiasis' supported by the sentence: 'This study investigated worm control practices by free-range egg farmers and the efficacy of the commercial anthelmintics levamisole (LEV), piperazine (PIP), flubendazole (FLBZ) and fenbendazole (FBZ) against gastrointestinal nematodes on two free-range layer farms in Australia.'?","Yes, the statement does provide indirect support for the claim that ""Fenbendazole treats helminthiasis"". Helminthiasis is a medical condition characterized by parasitic worm infestation, often in the gastrointestinal tract. The study in question examined the efficacy of various anthelmintics (deworming agents) against gastrointestinal nematodes on free-range layer farms in Australia. Fenbendazole (FBZ) was one such anthelmintic included in the investigation. +24413653,Fenbendazole treats helminthiasis,1001,"This study investigated worm control practices by free-range egg farmers and the efficacy of the commercial anthelmintics levamisole (LEV), piperazine (PIP), flubendazole (FLBZ) and fenbendazole (FBZ) against gastrointestinal nematodes on two free-range layer farms in Australia.",True,"'Does the phrase ""Fenbendazole treats helminthiasis"" receive at least indirect support from the statement: ""This study investigated worm control practices by free-range egg farmers and the efficacy of the commercial anthelmintics levamisole (LEV), piperazine (PIP), flubendazole (FLBZ) and fenbendazole (FBZ) against gastrointestinal nematodes on two free-range layer farms in Australia.""?","Yes, the statement does provide indirect support for the claim that ""Fenbendazole treats helminthiasis."" The study investigates the efficacy of various anthelmintics, including fenbendazole (FBZ), against gastrointestinal nematodes on two free-range layer farms in Australia. Helminthiasis is defined as an infection by parasitic worms; thus, gastrointestinal nematodes fall under this category. The fact that fenbendazole is one of the anthelmintics being studied for its efficacy against these parasitic worms implies that it has potential therapeutic effects on helminthiasis. However, it is important to note that direct evidence of fenbendazole treating helminthiasis in this study would require worm burden analyses before and after treatment with fenbendazole specifically, which is not explicitly stated in the provided statement." +9783282,Thiabendazole treats helminthiasis,1002,[The treatment of helminthiasis with thiabendazole].,True,"'Does the phrase ""Thiabendazole treats helminthiasis"" receive at least indirect support from the statement: ""[The treatment of helminthiasis with thiabendazole].""?","Yes, the phrase ""Thiabendazole treats helminthiasis"" does receive indirect support from the statement: ""[The treatment of helminthiasis with thiabendazole]."" - Although the statement does not explicitly confirm that fenbendazole treats helminthiasis in all contexts, it does demonstrate that fenbendazole has been studied for its effectiveness against gastrointestinal nematodes in specific situations (free-range egg farming in Australia). The fact that fenbendazole was selected for investigation in such a study suggests that it is recognized within the scientific community as having potential therapeutic value for treating worm infestations in certain hosts. + The statement implies that thiabendazole is being used as a treatment for helminthiasis. This suggests that thiabendazole has some therapeutic effect on helminthiasis, which aligns with the phrase ""Thiabendazole treats helminthiasis."" However, it's important to note that while the statement provides indirect support, it doesn't constitute definitive proof of the phrase's truthfulness. Further evidence from clinical trials or peer-reviewed studies would be needed for a more robust confirmation of thiabendazole's efficacy in treating helminthiasis." +22678969,Albendazole treats Infection,1003,The control of STH infections is based on preventive chemotherapy using either albendazole or mebendazole.,True,"'Does the phrase ""Albendazole treats Infection"" receive at least indirect support from the statement: ""The control of STH infections is based on preventive chemotherapy using either albendazole or mebendazole.""?","Yes, the phrase ""Albendazole treats Infection"" does receive indirect support from the statement: ""The control of STH infections is based on preventive chemotherapy using either albendazole or mebendazole."" - However, it is crucial to emphasize that evidence from one study does not automatically generalize to all contexts; further investigation may be required to establish" -9783282,Thiabendazole treats helminthiasis,1002,[The treatment of helminthiasis with thiabendazole].,True,Is the triple 'Thiabendazole treats helminthiasis' supported by the sentence: '[The treatment of helminthiasis with thiabendazole].'?,"Yes, the phrase ""Thiabendazole treats helminthiasis"" does receive indirect support from the statement: ""[The treatment of helminthiasis with thiabendazole]."" + The statement suggests that albendazole is used in preventive chemotherapy for STH (Soil Transmitted Helminths) infections, which implies that it has therapeutic effects against these infections. This is in line with the general understanding that chemotherapy is a treatment method using chemicals (in this case, drugs like albendazole) to treat diseases or infections. Therefore, it can be inferred that albendazole does indeed treat infections, even though the original statement does not explicitly mention this. However, it is important to note that the specific types of infections it treats (STH infections) are only inferred from the context provided." +10750815,Albendazole treats onchocerciasis,1004,"A double-blind clinical trial was conducted in Monagas State, Venezuela to assess the tolerance and efficacy of albendazole in the therapy of Onchocerca volvulus infection.",True,"'Does the phrase ""Albendazole treats onchocerciasis"" receive at least indirect support from the statement: ""A double-blind clinical trial was conducted in Monagas State, Venezuela to assess the tolerance and efficacy of albendazole in the therapy of Onchocerca volvulus infection.""?","Yes, the statement does provide indirect support for the claim that Albendazole treats onchocerciasis (Onchocerca volvulus infection). The clinical trial mentioned in the statement was designed to assess both tolerance (safety) and efficacy (effectiveness) of Albendazole in treating Onchocerca volvulus infection. Efficacy refers to the ability of a treatment to produce a desired result under ideal conditions; in this case, eliminating or reducing Onchocerca volvulus infection. - + While the statement does not explicitly confirm that albendazole was found effective in treating onchocerciasis in Monagas State, Venezuela, it does suggest that such an assessment was carried out as part of the trial objectives. Therefore, it is reasonable to infer that there is some basis for supporting albendazole as a treatment for onchocerciasis based on the described clinical trial; however, direct access to trial results would be required for a definitive conclusion. - The statement ""[The treatment of helminthiasis with thiabendazole]"" implies that thiabendazole is being used as a means to treat helminthiasis. Therefore, it can be inferred that thiabendazole has some therapeutic effect on helminthiasis, which is what the phrase ""Thiabendazole treats helminthiasis"" conveys. + It is important to note that evidence from individual clinical trials may be subject to limitations such as sample size, participant demographics, dosage levels, follow-up periods," +10114050,Albendazole treats toxocariasis,1005,"The treatment of cutaneous larva migrans and Toxocara infection relies on antihelminthic agents such as thiabendazole, albendazole and ivermectin.",True,"'Does the phrase ""Albendazole treats toxocariasis"" receive at least indirect support from the statement: ""The treatment of cutaneous larva migrans and Toxocara infection relies on antihelminthic agents such as thiabendazole, albendazole and ivermectin.""?","Yes, the phrase ""Albendazole treats toxocariasis"" does receive indirect support from the statement: ""The treatment of cutaneous larva migrans and Toxocara infection relies on antihelminthic agents such as thiabendazole, albendazole and ivermectin."" - + The statement clearly identifies albendazole as one of the antihelminthic agents used in treating Toxocara infections. Toxocariasis is a condition caused by Toxocara canis or Toxocara cati larvae, which is what is being referred to in this context. Therefore, it indirectly supports the claim that albendazole is used in treating toxocariasis. - However, it is important to note that indirect support does not equate to definitive proof. While the statement suggests that thiabendazole may be an effective treatment for helminthiasis, further investigation would be necessary to confirm its efficacy, safety profile, and optimal usage conditions. This might involve randomized controlled trials, meta-analyses, and other rigorous scientific studies. + However, it is important to note that while albendazole is an effective treatment for many parasitic infections, including some forms of toxocariasis, its effectiveness can depend on various factors such as the specific type of Toxocara infection, the severity of symptoms, and the individual patient's health status. Therefore, while the statement provides indirect support for the claim, it does not" +9588560,Albendazole treats trichuriasis,1006,"Three randomized clinical studies were conducted in 2000 to evaluate the efficacy of nitazoxanide paediatric suspension compared to albendazole in the treatment of ascariasis and trichuriasis and praziquantel in the treatment of hymenolepiasis in children from Cajamarca, Peru.",True,"'Does the phrase ""Albendazole treats trichuriasis"" receive at least indirect support from the statement: ""Three randomized clinical studies were conducted in 2000 to evaluate the efficacy of nitazoxanide paediatric suspension compared to albendazole in the treatment of ascariasis and trichuriasis and praziquantel in the treatment of hymenolepiasis in children from Cajamarca, Peru.""?","Yes, the statement does provide indirect support for the claim that albendazole treats trichuriasis. The randomized clinical studies mentioned in the statement compared albendazole to other treatments for ascariasis, trichuriasis, and hymenolepiasis in children from Cajamarca, Peru. The fact that albendazole was included in these studies suggests that it is recognized as a potential treatment for trichuriasis in the medical community. However, these studies do not explicitly demonstrate that albendazole treats trichuriasis; they only show that it was compared to other treatments for trichuriasis in clinical trials. Further investigation would be necessary to confirm whether albendazole is an effective treatment for trichuriasis specifically." +9492446,Albendazole treats filariasis,1007,"Today, the only way is the prophylactic control of Onchocerca vovulus infections and treating lymphatic filariosis with ivermectin, diethylcarbamacine, ivermectin/diethylcarbamazine. or ivermectin/albendazole combinations.",True,"'Does the phrase ""Albendazole treats filariasis"" receive at least indirect support from the statement: ""Today, the only way is the prophylactic control of Onchocerca vovulus infections and treating lymphatic filariosis with ivermectin, diethylcarbamacine, ivermectin/diethylcarbamazine. or ivermectin/albendazole combinations.""?","Yes, the phrase ""Albendazole treats filariasis"" does receive indirect support from the statement provided. - + The statement mentions that lymphatic filariosis is treated with ivermectin, diethylcarbamazine, ivermectin/diethylcarbamazine combinations, or ivermectin/albendazole combinations. This implies that albendazole is used in combination therapy for treating filariasis caused by Onchocerca volvulus or lymphatic filariasis caused by other parasites like Wuchereria bancrofti and Brugia malayi. Therefore, it indirectly supports the claim that albendazole is used in treating filariasis. - In conclusion, while the statement does provide some level of support for the claim that th" -22678969,Albendazole treats Infection,1003,The control of STH infections is based on preventive chemotherapy using either albendazole or mebendazole.,True,Is the triple 'Albendazole treats Infection' supported by the sentence: 'The control of STH infections is based on preventive chemotherapy using either albendazole or mebendazole.'?,"Yes, the phrase ""Albendazole treats Infection"" does receive indirect support from the statement: ""The control of STH infections is based on preventive chemotherapy using either albendazole or mebendazole."" + However, it is important to note that albendazole is not typically used as a standalone treatment for filariasis but rather in combination therapy as stated in the provided statement. This nuance should be taken into account when interpreting the evidence provided." +8712067,Albendazole treats helminthiasis,1008,The study population was assessed for helminthic infection and those found to be positive were randomly assigned to either an albendazole treatment group or a control group who received a placebo.,True,"'Does the phrase ""Albendazole treats helminthiasis"" receive at least indirect support from the statement: ""The study population was assessed for helminthic infection and those found to be positive were randomly assigned to either an albendazole treatment group or a control group who received a placebo.""?","Yes, the statement does provide indirect support for the claim that ""Albendazole treats helminthiasis"". This is because conducting a study where participants diagnosed with helminthic infection (helminthiasis) were randomly assigned into either an albendazole treatment group or a control group receiving placebo implies that albendazole is being investigated for its potential therapeutic effect on helminthiasis. - The statement suggests that albendazole is one of the primary medications used in preventive chemotherapy for soil-transmitted helminth (STH) infections, which implies that it has therapeutic efficacy against these parasites. Therefore, it can be inferred that albendazole does treat infections caused by STH parasites. However, it is essential to note that this interpretation is based on an indirect inference, as the original statement does not explicitly mention that albendazole treats infections but rather focuses on its use in preventive chemotherapy programs." -10750815,Albendazole treats onchocerciasis,1004,"A double-blind clinical trial was conducted in Monagas State, Venezuela to assess the tolerance and efficacy of albendazole in the therapy of Onchocerca volvulus infection.",True,"Is the triple 'Albendazole treats onchocerciasis' supported by the sentence: 'A double-blind clinical trial was conducted in Monagas State, Venezuela to assess the tolerance and efficacy of albendazole in the therapy of Onchocerca volvulus infection.'?","Yes, the statement does provide indirect support for the claim that Albendazole treats onchocerciasis (also known as river blindness). The clinical trial being conducted in Monagas State, Venezuela aimed to assess both the tolerance (how well it is tolerated by patients) and efficacy (how effectively it works) of albendazole in treating Onchocerca volvulus infection, which is a parasitic infection that can lead to onchocerciasis if left untreated. + The random assignment of participants into two groups is a standard practice in clinical trials investigating potential treatments for various health conditions. The fact that one group received albendazole suggests that there is an expectation within the study design that albendazole may have an impact on helminthic infection. However, it should be noted that direct support for the claim would require additional information about the outcomes of such a study, such as whether there was a significant difference between the treatment group and control group in terms of resolution of helminthic infection." +7789677,Albendazole treats strongyloidiasis,1009,"To determine the host factors involved in response to treatment, 46 patients with strongyloidiasis were treated with albendazole, followed-up for 1 year, and separated into two groups: cured and non-cured.",True,"'Does the phrase ""Albendazole treats strongyloidiasis"" receive at least indirect support from the statement: ""To determine the host factors involved in response to treatment, 46 patients with strongyloidiasis were treated with albendazole, followed-up for 1 year, and separated into two groups: cured and non-cured.""?","Yes, the statement does provide indirect support for the claim that Albendazole treats strongyloidiasis. The fact that 46 patients diagnosed with strongyloidiasis were treated with Albendazole indicates that it is being used as a treatment option for this condition. Furthermore, the follow-up period of one year suggests that the researchers were interested in observing the long-term effects of the treatment, which is consistent with the typical use of antibiotics like Albendazole for parasitic infections. However, it's important to note that this statement does not directly demonstrate that Albendazole cures strongyloidiasis, as it only shows an association between treatment and outcome. The distinction between correlation and causation should be kept in mind when interpreting these results." +7640018,Albendazole treats filarial elephantiasis,1010,The role of albendazole in programmes to eliminate lymphatic filariasis.,True,"'Does the phrase ""Albendazole treats filarial elephantiasis"" receive at least indirect support from the statement: ""The role of albendazole in programmes to eliminate lymphatic filariasis.""?","Yes, the statement ""The role of albendazole in programmes to eliminate lymphatic filariasis"" does provide indirect support for the phrase ""Albendazole treats filarial elephantiasis"". This is because filarial elephantiasis is caused by parasitic filarial worms, which lymphatic filariasis is a disease resulting from infection by these worms. Albendazole is an anthelmintic drug commonly used in mass drug administration programs aimed at eliminating lymphatic filariasis. By targeting and killing the microfilariae (immature larvae) of these filarial worms, albendazole can help reduce the transmission of lymphatic filariasis in endemic areas and alleviate associated symptoms like filarial elephantiasis over time. However, it is important to note that albendazole alone may not cure filarial elephantiasis; it is often used in combination with other medications like diethylcarbamazine (DEC) and ivermectin for more effective treatment outcomes." +7620262,Albendazole treats Hookworm Infections,1011,On the basis of our results the single 400 mg dose of albendazole is the treatment of choice for hookworm infections in this region of Mali.,True,"'Does the phrase ""Albendazole treats Hookworm Infections"" receive at least indirect support from the statement: ""On the basis of our results the single 400 mg dose of albendazole is the treatment of choice for hookworm infections in this region of Mali.""?","Yes, the phrase ""Albendazole treats Hookworm Infections"" does receive indirect support from the statement: ""On the basis of our results the single 400 mg dose of albendazole is the treatment of choice for hookworm infections in this region of Mali."" - While the statement does not explicitly confirm that albendazole treats onchocerciasis successfully, it does indicate that researchers have investigated its potential as a therapeutic option for Onchocerca volvulus infection. The fact that a clinical trial was undertaken suggests that there is some basis for considering albendazole as a potential treatment for onchocerciasis in medical research circles. + The statement implies that albendazole is an effective treatment for hookworm infections in the specified region of Mali. This suggests that albendazole has some level of efficacy in treating hookworm infections, providing indirect support for the claim that albendazole treats hookworm infections. However, it's important to note that the claim is not directly supported because the statement only refers to the efficacy of albendazole in a specific region of Mali, not globally. Furthermore, the statement does not provide any details about the mechanism of action of albendazole against hookworm infections. Therefore, while there is indirect support for the claim, it is not conclusively proven by the statement alone." +7226097,Albendazole treats cysticercosis,1012,The efficacy of albendazole (15 mg/kg/d for 1 week) was compared with praziquantel (100 mg/kg in three divided doses at 2-hour intervals) for therapy of parenchymal brain cysticercosis.,True,"'Does the phrase ""Albendazole treats cysticercosis"" receive at least indirect support from the statement: ""The efficacy of albendazole (15 mg/kg/d for 1 week) was compared with praziquantel (100 mg/kg in three divided doses at 2-hour intervals) for therapy of parenchymal brain cysticercosis.""?","Yes, the statement does provide indirect support for the claim that Albendazole treats cysticercosis. The study mentioned compares the efficacy of Albendazole and Praziquantel in treating parenchymal brain cysticercosis. The fact that Albendazole is included in such a study suggests that it has some therapeutic effect on cysticercosis, thus providing indirect support for the claim that Albendazole treats cysticercosis. However, it is important to note that this does not directly prove that Albendazole is an effective treatment for cysticercosis in all cases or in all stages of the disease, as it may depend on various factors such as dosage, duration of treatment, patient's overall health status, among others." +25678577,Latamoxef treats bacterial infectious disease,1013,"Clinical efficacy and safety of a new oxacephem, moxalactam, in serious bacterial infections.",True,"'Does the phrase ""Latamoxef treats bacterial infectious disease"" receive at least indirect support from the statement: ""Clinical efficacy and safety of a new oxacephem, moxalactam, in serious bacterial infections.""?","Yes, there is indirect support for the statement that ""Latamoxef treats bacterial infectious disease"" from the given statement about moxalactam, another oxacephem antibiotic like Latamoxef. - However, it is important to note that further information would be required in order to fully evaluate the evidence provided by the statement. For example, knowledge about the outcomes of that clinical trial would be valuable in determining whether albendazole indeed is an effective treatment for onch" -10114050,Albendazole treats toxocariasis,1005,"The treatment of cutaneous larva migrans and Toxocara infection relies on antihelminthic agents such as thiabendazole, albendazole and ivermectin.",True,"Is the triple 'Albendazole treats toxocariasis' supported by the sentence: 'The treatment of cutaneous larva migrans and Toxocara infection relies on antihelminthic agents such as thiabendazole, albendazole and ivermectin.'?","Yes, the statement does provide indirect support for the phrase ""Albendazole treats toxocariasis."" The reason is that cutaneous larva migrans and Toxocara infection are two different clinical manifestations caused by parasitic worms (nematodes). Toxocara infection refers specifically to Toxocariasis which is caused by Toxocara canis or Toxocara cati larvae that infect humans. + The statement ""Clinical efficacy and safety of a new oxacephem, moxalactam, in serious bacterial infections"" suggests that moxalactam is effective in treating serious bacterial infections, implying that it has antibacterial properties. Latamoxef is also an oxacephem antibiotic, meaning it shares structural similarities and likely pharmacological properties with moxalactam. - The statement mentions that antihelminthic agents such as albendazole can be used in treating these infections. This implies that albendazole has some therapeutic effect on nematode infections in humans including Toxocariasis (toxocara infection). Therefore, it can be inferred that albendazole treats toxocariasis based on this indirect support. However, it is important to note that direct clinical trials may be required for definitive evidence regarding albendazole's efficacy in treating Toxocariasis specifically." -9588560,Albendazole treats trichuriasis,1006,"Three randomized clinical studies were conducted in 2000 to evaluate the efficacy of nitazoxanide paediatric suspension compared to albendazole in the treatment of ascariasis and trichuriasis and praziquantel in the treatment of hymenolepiasis in children from Cajamarca, Peru.",True,"Is the triple 'Albendazole treats trichuriasis' supported by the sentence: 'Three randomized clinical studies were conducted in 2000 to evaluate the efficacy of nitazoxanide paediatric suspension compared to albendazole in the treatment of ascariasis and trichuriasis and praziquantel in the treatment of hymenolepiasis in children from Cajamarca, Peru.'?","Yes, the statement does provide indirect support for the claim that albendazole treats trichuriasis. The randomized clinical studies conducted in 2000 compared nitazoxanide paediatric suspension and albendazole in treating ascariasis and trichuriasis in children from Cajamarca, Peru. The fact that albendazole was included in these studies suggests that it is recognized as a potential treatment for trichuriasis in published research. However, it is essential to review these studies in detail to evaluate albendazole's efficacy in treating trichuriasis specifically, as they involved comparisons against other treatments as well (nitazoxanide paediatric suspension in this case). + Therefore, based on the evidence that moxalactam treats bacterial infections, it can be reasonably inferred that Latamoxef may have similar effects due to their shared classification as oxacephem antibiotics. However, it is essential to note that direct evidence should be sought for Latamoxef specifically before making definitive conclusions about its therapeutic utility for bacterial infections. - In summary, while these studies do not directly prove that albendazole treats trichuriasis, they do provide evidence that albendazole is considered an appropriate treatment option for trichuriasis in clinical trials, which indirectly supports its efficacy as a treatment for trichuriasis." -9492446,Albendazole treats filariasis,1007,"Today, the only way is the prophylactic control of Onchocerca vovulus infections and treating lymphatic filariosis with ivermectin, diethylcarbamacine, ivermectin/diethylcarbamazine. or ivermectin/albendazole combinations.",True,"Is the triple 'Albendazole treats filariasis' supported by the sentence: 'Today, the only way is the prophylactic control of Onchocerca vovulus infections and treating lymphatic filariosis with ivermectin, diethylcarbamacine, ivermectin/diethylcarbamazine. or ivermectin/albendazole combinations.'?","Yes, the statement does provide indirect support for the claim that Albendazole treats filariasis (lymphatic filariosis). The text clearly states that ivermectin/albendazole combinations are used in treating lymphatic filariosis, which is another name for filariasis caused by Wuchereria bancrofti. This indicates that albendazole is indeed utilized in treating filariasis when used in combination with ivermectin. However, it is essential to note that albendazole alone may not be sufficient for treating filariasis; it is typically used in combination therapy." -8712067,Albendazole treats helminthiasis,1008,The study population was assessed for helminthic infection and those found to be positive were randomly assigned to either an albendazole treatment group or a control group who received a placebo.,True,Is the triple 'Albendazole treats helminthiasis' supported by the sentence: 'The study population was assessed for helminthic infection and those found to be positive were randomly assigned to either an albendazole treatment group or a control group who received a placebo.'?,"Yes, the statement does provide indirect support for the phrase ""Albendazole treats helminthiasis"". This is because it indicates that participants diagnosed with helminthic infection were given Albendazole as part of a treatment group in a clinical study. The positive correlation between treatment with Albendazole and resolution of helminthic infection would provide evidence supporting the claim that Albendazole treats helminthiasis. However, it is important to note that direct support would require analysis of outcomes in the treatment group versus the control group, which is not explicitly stated in the original statement." -7789677,Albendazole treats strongyloidiasis,1009,"To determine the host factors involved in response to treatment, 46 patients with strongyloidiasis were treated with albendazole, followed-up for 1 year, and separated into two groups: cured and non-cured.",True,"Is the triple 'Albendazole treats strongyloidiasis' supported by the sentence: 'To determine the host factors involved in response to treatment, 46 patients with strongyloidiasis were treated with albendazole, followed-up for 1 year, and separated into two groups: cured and non-cured.'?","Yes, the statement does provide indirect support for the claim that Albendazole treats strongyloidiasis. The fact that 46 patients diagnosed with strongyloidiasis were treated with Albendazole indicates that it is being used as a treatment option for this condition. Furthermore, the follow-up period of one year suggests an attempt to evaluate the long-term effectiveness of the treatment, which is consistent with the aim of treating strongyloidiasis. However, it is important to note that while this study design allows for inference about the efficacy of Albendazole in treating strongyloidiasis, it does not definitively prove it because other factors like dosage, patient compliance, and potential confounding variables may influence treatment outcomes. Ideally, a randomized controlled trial would provide stronger evidence for the claim that Albendazole treats strongyloidiasis by comparing it against a placebo or another treatment in a more controlled setting." -7640018,Albendazole treats filarial elephantiasis,1010,The role of albendazole in programmes to eliminate lymphatic filariasis.,True,Is the triple 'Albendazole treats filarial elephantiasis' supported by the sentence: 'The role of albendazole in programmes to eliminate lymphatic filariasis.'?,"Yes, the statement ""The role of albendazole in programmes to eliminate lymphatic filariasis"" does provide indirect support for the phrase ""Albendazole treats filarial elephantiasis"". This is because albendazole is often used as part of mass drug administration (MDA) programs aimed at eliminating lymphatic filariasis (LF), which includes filarial elephantiasis as one of its clinical manifestations. + To strengthen the argument for Latamoxef treating bacterial infections, further investigation into clinical trials, observ" +26824955,Ibuprofen treats spondylosis,1014,A comparison of the short-term effects of ibuprofen and diclofenac in spondylosis.,False,"'Does the phrase ""Ibuprofen treats spondylosis"" receive at least indirect support from the statement: ""A comparison of the short-term effects of ibuprofen and diclofenac in spondylosis.""?","No, the statement ""A comparison of the short-term effects of ibuprofen and diclofenac in spondylosis"" does not provide direct or indirect support for the claim ""Ibuprofen treats spondylosis."" The statement is merely comparing two treatments (ibuprofen and diclofenac) in terms of their short-term effects on spondylosis patients; it does not confirm that ibuprofen is an effective treatment for spondylosis on its own. - However, it is important to note that while albendazole is effective in killing microfilariae (the larval stage) produced by adult worms in infected individuals, it does not directly treat filarial elephantiasis itself. The drug helps reduce transmission by decreasing microfilariae levels in communities where it is administered regularly through MDA programs. In turn, it can help alleviate symptoms in infected individuals by reducing worm burden over time. + - Nonetheless, filarial elephantiasis is typically caused by long-term infection and inflammation due to adult worms living in the lymphatic system. Direct treatment for filarial elephantiasis primarily involves surgical" -7620262,Albendazole treats Hookworm Infections,1011,On the basis of our results the single 400 mg dose of albendazole is the treatment of choice for hookworm infections in this region of Mali.,True,Is the triple 'Albendazole treats Hookworm Infections' supported by the sentence: 'On the basis of our results the single 400 mg dose of albendazole is the treatment of choice for hookworm infections in this region of Mali.'?,"Yes, the phrase ""Albendazole treats Hookworm Infections"" does receive indirect support from the statement: ""On the basis of our results the single 400 mg dose of albendazole is the treatment of choice for hookworm infections in this region of Mali."" + The statement does suggest that there is some evidence of ibuprofen being used in relation to spondylosis treatment, but it does not necessarily mean that ibuprofen treats spondylosis effectively by itself. Additionally, diclofenac is also being compared in terms of its short-term effects on spondylosis patients; thus, it is not isolating ibuprofen as an effective treatment for spondylosis. - The statement suggests that albendazole is an effective treatment for hookworm infections in a specific region of Mali. This implies that albendazole has some therapeutic effect on hookworm infections, providing indirect support for the claim that albendazole treats hookworm infections. However, it is important to note that the effectiveness of albendazole may vary depending on the severity of the infection, the individual's health status, and other factors. Therefore, while the statement supports the idea that albendazole can treat hookworm infections, it does not necessarily confirm that albendazole is always effective in all cases and contexts." -7226097,Albendazole treats cysticercosis,1012,The efficacy of albendazole (15 mg/kg/d for 1 week) was compared with praziquantel (100 mg/kg in three divided doses at 2-hour intervals) for therapy of parenchymal brain cysticercosis.,True,Is the triple 'Albendazole treats cysticercosis' supported by the sentence: 'The efficacy of albendazole (15 mg/kg/d for 1 week) was compared with praziquantel (100 mg/kg in three divided doses at 2-hour intervals) for therapy of parenchymal brain cysticercosis.'?,"Yes, the statement does provide indirect support for the claim that Albendazole treats cysticercosis. The study referenced compares the efficacy of Albendazole and Praziquantel in treating parenchymal brain cysticercosis, which is a manifestation of cysticercosis caused by Taenia solium larvae (cysticerci) in the brain parenchyma. By implication, if Albendazole is shown to be effective in treating parenchymal brain cysticercosis in comparison to another drug in this study, it suggests that Albendazole indeed has therapeutic value in treating cysticercosis. + - However, it is important to note that direct support for the claim would require more specific information about the efficacy and safety profile of Albendazole in treating cysticercosis in comparison to no treatment or placebo. Additionally, further details on dosage regimens and potential side effects would be necessary for making definitive conclusions about its therapeutic utility in treating cysticercosis." -25678577,Latamoxef treats bacterial infectious disease,1013,"Clinical efficacy and safety of a new oxacephem, moxalactam, in serious bacterial infections.",False,"Is the triple 'Latamoxef treats bacterial infectious disease' supported by the sentence: 'Clinical efficacy and safety of a new oxacephem, moxalactam, in serious bacterial infections.'?","No, the statement ""Clinical efficacy and safety of a new oxacephem, moxalactam, in serious bacterial infections"" does not provide direct support for the phrase ""Latamoxef treats bacterial infectious disease"". + In order for there to be direct support for the claim ""Ibuprofen treats spondylosis,"" there would need to be evidence that specifically demonstrates ibuprofen as an effective treatment for spond" +25670779,Ibuprofen treats sunburn,1015,"The data suggest that ibuprofen is more effective than placebo for the relief of symptoms associated with UV-B-induced inflammation after high dose UV-B phototherapy for psoriasis, but the drug has limited usefulness in the treatment of sunburn reaction from these same doses.",True,"'Does the phrase ""Ibuprofen treats sunburn"" receive at least indirect support from the statement: ""The data suggest that ibuprofen is more effective than placebo for the relief of symptoms associated with UV-B-induced inflammation after high dose UV-B phototherapy for psoriasis, but the drug has limited usefulness in the treatment of sunburn reaction from these same doses.""?","Yes, indirect support can be inferred from the statement provided. The key point here is that ibuprofen has been found to be more effective than placebo in alleviating symptoms associated with UV-B-induced inflammation after high dose UV-B phototherapy for psoriasis. While it's true that the statement mentions limited usefulness in treating sunburn reaction from these same doses, it doesn't explicitly negate the potential benefits of ibuprofen in treating sunburn in general. - Although both Latamoxef and Moxalactam belong to the oxacephem class of antibiotics which are known for their effectiveness against bacterial infections, they are distinct compounds. The clinical trial result mentioned supports Moxalactam but does not provide any evidence for Latamoxef specifically treating bacterial infectious disease. + Sunburn is essentially an inflammatory response to UV radiation damage, which is similar to the UV-B-induced inflammation mentioned in the statement. Therefore, it's reasonable to infer that ibuprofen could potentially have some beneficial effects on sunburn symptoms due to its anti-inflammatory properties. However, it's important to note that this inference is based on indirect evidence and further research would be needed to confirm whether ibuprofen is an effective treatment for sunburn specifically." +25518118,Ibuprofen treats Fractured ankle,1016,"Huoxue Huayu Recipe combined with ibuprofen can reduce inflammatory factors levels in patients with ankle fracture, improve isokinetic muscle strength and ankle function, and accelerate the recovery of patients.",True,"'Does the phrase ""Ibuprofen treats Fractured ankle"" receive at least indirect support from the statement: ""Huoxue Huayu Recipe combined with ibuprofen can reduce inflammatory factors levels in patients with ankle fracture, improve isokinetic muscle strength and ankle function, and accelerate the recovery of patients.""?","Yes, indirectly it does lend some support to the claim that ibuprofen can be beneficial in treating fractured ankles. The statement suggests that when ibuprofen is used in combination with the Huoxue Huayu Recipe (a traditional Chinese medicine), it leads to reduced inflammatory factors levels in patients with ankle fractures. This implies that ibuprofen could potentially contribute to improved isokinetic muscle strength, ankle function, and accelerated recovery in these patients. - However, it should be noted that since they belong to the same class, they share similar mechanisms of action; thus, one could infer that if moxalactam is effective against bacterial infections, then other oxacephems like latamoxef might also be effective. But such an inference would still not constitute direct evidence for Latamoxef's efficacy against bacterial infections." -26824955,Ibuprofen treats spondylosis,1014,A comparison of the short-term effects of ibuprofen and diclofenac in spondylosis.,False,Is the triple 'Ibuprofen treats spondylosis' supported by the sentence: 'A comparison of the short-term effects of ibuprofen and diclofenac in spondylosis.'?,"No, the statement ""A comparison of the short-term effects of ibuprofen and diclofenac in spondylosis"" does not provide direct support for the claim that ""Ibuprofen treats spondylosis."" The statement only mentions a comparison between ibuprofen and diclofenac in terms of their short-term effects on spondylosis; it does not confirm that ibuprofen is an effective treatment for spondylosis. Indirect support may be possible if ibuprofen demonstrates superior short-term effects compared to diclofenac in treating spondylosis; however, further investigation would be required for more definitive evidence." -25670779,Ibuprofen treats sunburn,1015,"The data suggest that ibuprofen is more effective than placebo for the relief of symptoms associated with UV-B-induced inflammation after high dose UV-B phototherapy for psoriasis, but the drug has limited usefulness in the treatment of sunburn reaction from these same doses.",False,"Is the triple 'Ibuprofen treats sunburn' supported by the sentence: 'The data suggest that ibuprofen is more effective than placebo for the relief of symptoms associated with UV-B-induced inflammation after high dose UV-B phototherapy for psoriasis, but the drug has limited usefulness in the treatment of sunburn reaction from these same doses.'?","No, the statement does not provide indirect support for the phrase ""Ibuprofen treats sunburn."" The study referenced in the statement investigates ibuprofen's effectiveness in relieving symptoms associated with UV-B-induced inflammation after high dose UV-B phototherapy for psoriasis. Although ibuprofen has demonstrated efficacy in treating symptoms related to UV-B-induced inflammation in psoriasis patients undergoing phototherapy, it does not necessarily imply that ibuprofen is an effective treatment for sunburn reactions resulting from UV-B exposure in non-psoriasis patients. + However, it is important to note that correlation does not imply causation. The specific effects of ibuprofen cannot be definitively determined from this statement alone since it is part of a combination therapy. Further studies isolating ibuprofen as a treatment would be needed for stronger evidence supporting its direct effects on fractured ankles." +25321029,Ibuprofen treats bronchopulmonary dysplasia,1017,"Treatment of newborn rat pups with ibuprofen reduced pulmonary vessel density in the developing lung, but also attenuated experimental BPD by reducing lung inflammation, alveolar enlargement, alveolar septum thickness and small arteriolar wall thickening.",True,"'Does the phrase ""Ibuprofen treats bronchopulmonary dysplasia"" receive at least indirect support from the statement: ""Treatment of newborn rat pups with ibuprofen reduced pulmonary vessel density in the developing lung, but also attenuated experimental BPD by reducing lung inflammation, alveolar enlargement, alveolar septum thickness and small arteriolar wall thickening.""?","Yes, indirect support can be inferred from the statement provided. The claim that ibuprofen treats bronchopulmonary dysplasia (BPD) is essentially saying that ibuprofen has therapeutic effects on BPD. The statement mentions that ibuprofen reduces lung inflammation, alveolar enlargement, alveolar septum thickness, and small arteriolar wall thickening in newborn rat pups. These factors are closely related to the pathophysiology of BPD, which involves inflammation, arrested alveolar development, and vascular remodeling. Therefore, by addressing these aspects, ibuprofen could potentially ameliorate BPD symptoms, providing indirect support for the claim. However, it is important to note that this is based on animal studies, and further research in humans is needed before making definitive conclusions about ibuprofen as a treatment for BPD in humans." +22125431,Ibuprofen treats preeclampsia,1018,Introduction: The comparison of ibuprofen with acetaminophen for blood pressure (BP) in preeclampsia remains controversial.,False,"'Does the phrase ""Ibuprofen treats preeclampsia"" receive at least indirect support from the statement: ""Introduction: The comparison of ibuprofen with acetaminophen for blood pressure (BP) in preeclampsia remains controversial.""?","No, the statement ""Ibuprofen treats preeclampsia"" does not receive indirect support from the provided statement. The statement in question only introduces a controversy about whether ibuprofen is more effective than acetaminophen in managing blood pressure in preeclampsia patients. It does not confirm that ibuprofen can treat preeclampsia itself. - The study specifically mentions that ibuprofen has limited usefulness in treating sunburn reactions from high dose UV-B phototherapy in psoriasis patients. This finding suggests that ibuprofen may not be as effective for treating sunburn as other treatments specifically designed for addressing sunburn symptoms. + The statement focuses on comparing ibuprofen with acetaminophen in managing blood pressure in preeclampsia patients rather than treating preeclampsia itself. Therefore, it does not provide any evidence supporting the claim that ibuprofen treats preeclampsia but merely states that there is controversy regarding its use for blood pressure management in these patients. - In summary, while ibuprofen has demonstrated some benefits for treating symptoms associated with UV-B-induced inflammation in psoriasis patients undergoing phototherapy, it does not provide indirect support for the claim that ibuprofen treats sun" -25518118,Ibuprofen treats Fractured ankle,1016,"Huoxue Huayu Recipe combined with ibuprofen can reduce inflammatory factors levels in patients with ankle fracture, improve isokinetic muscle strength and ankle function, and accelerate the recovery of patients.",True,"Is the triple 'Ibuprofen treats Fractured ankle' supported by the sentence: 'Huoxue Huayu Recipe combined with ibuprofen can reduce inflammatory factors levels in patients with ankle fracture, improve isokinetic muscle strength and ankle function, and accelerate the recovery of patients.'?","Yes, indirectly it does lend some support. The statement suggests that using ibuprofen in conjunction with a traditional Chinese medicine recipe (Huoxue Huayu Recipe) for patients with ankle fractures leads to reduced inflammatory factors levels, improved isokinetic muscle strength, enhanced ankle function, and faster recovery. While the statement does not explicitly claim that ibuprofen alone treats fractured ankles, it does imply that ibuprofen contributes positively to the healing process when used as part of a treatment regimen for ankle fractures. + It is crucial to differentiate between treating a disease (preeclampsia) and managing symptoms (blood pressure) when interpreting medical literature. The provided statement only addresses managing symptoms associated with preeclampsia rather than treating preeclampsia itself." +21268743,Ibuprofen treats glioma,1019,"Taken together, our findings reveal that ibuprofen could induce ferroptosis of glioblastoma cells via downregulation of Nrf2 signaling pathway and is a potential drug for glioma treatment.",True,"'Does the phrase ""Ibuprofen treats glioma"" receive at least indirect support from the statement: ""Taken together, our findings reveal that ibuprofen could induce ferroptosis of glioblastoma cells via downregulation of Nrf2 signaling pathway and is a potential drug for glioma treatment.""?","Yes, the statement does provide indirect support for the phrase ""Ibuprofen treats glioma."" The statement suggests that ibuprofen could induce ferroptosis of glioblastoma cells, which are a type of glioma cell. Furthermore, it indicates that this could occur via downregulation of the Nrf2 signaling pathway, suggesting a specific mechanism of action. The use of terms such as ""treatment"" and ""potential drug"" also imply that ibuprofen could have therapeutic effects in glioma. However, it is important to note that this is based on in vitro findings and further research is needed to confirm these effects in vivo and in clinical settings." +20821983,Ibuprofen treats common cold,1020,Ibuprofen (IBU) and phenylephrine hydrochloride (PE) were commonly used for common cold due to their different effects in relieving fever and the main symptoms such as nasal congestion and high sinus pressure.,False,"'Does the phrase ""Ibuprofen treats common cold"" receive at least indirect support from the statement: ""Ibuprofen (IBU) and phenylephrine hydrochloride (PE) were commonly used for common cold due to their different effects in relieving fever and the main symptoms such as nasal congestion and high sinus pressure.""?","No, the statement does not provide indirect support for the phrase ""Ibuprofen treats common cold."" The original statement suggests that Ibuprofen (IBU) and phenylephrine hydrochloride (PE) were commonly used for treating common cold symptoms like fever and nasal congestion; however, it does not explicitly connect ibuprofen as an effective treatment for the common cold itself. The statement only supports that ibuprofen can alleviate certain symptoms associated with the common cold but does not provide evidence that it treats the underlying cause of the common cold." +20285347,Ibuprofen treats periodontitis,1021,"Therefore, the objective of this study was to investigate the local delivery of the NSAIDs model drug ibuprofen to treat periodontitis using different types of gel formulations (hydrogel, oleogel, and bigel).",True,"'Does the phrase ""Ibuprofen treats periodontitis"" receive at least indirect support from the statement: ""Therefore, the objective of this study was to investigate the local delivery of the NSAIDs model drug ibuprofen to treat periodontitis using different types of gel formulations (hydrogel, oleogel, and bigel).""?","Yes, the statement does provide indirect support for the phrase ""Ibuprofen treats periodontitis."" The objective of the study as stated is to investigate the local delivery of ibuprofen (an NSAID) for treating periodontitis using various gel formulations. This implies that ibuprofen is being considered as a potential treatment for periodontitis in this study. However, it should be noted that this does not constitute direct evidence of ibuprofen's efficacy in treating periodontitis. The results of the study would need to be evaluated to make such a determination." +19270581,Ibuprofen treats bone fracture,1022,Does the Use of Ibuprofen in Children with Extremity Fractures Increase their Risk for Bone Healing Complications?,False,"'Does the phrase ""Ibuprofen treats bone fracture"" receive at least indirect support from the statement: ""Does the Use of Ibuprofen in Children with Extremity Fractures Increase their Risk for Bone Healing Complications?""?","No, the statement ""Does the Use of Ibuprofen in Children with Extremity Fractures Increase their Risk for Bone Healing Complications?"" does not provide indirect support for the phrase ""Ibuprofen treats bone fracture."" - - However, it is crucial to note that correlation does not imply causation; therefore, we cannot definitively conclude that ibuprofen alone treats ankle fractures based solely on this information. Further studies specifically investigating ibuprofen as monotherapy for ankle fractures would be required for stronger support for that claim." -25321029,Ibuprofen treats bronchopulmonary dysplasia,1017,"Treatment of newborn rat pups with ibuprofen reduced pulmonary vessel density in the developing lung, but also attenuated experimental BPD by reducing lung inflammation, alveolar enlargement, alveolar septum thickness and small arteriolar wall thickening.",True,"Is the triple 'Ibuprofen treats bronchopulmonary dysplasia' supported by the sentence: 'Treatment of newborn rat pups with ibuprofen reduced pulmonary vessel density in the developing lung, but also attenuated experimental BPD by reducing lung inflammation, alveolar enlargement, alveolar septum thickness and small arteriolar wall thickening.'?","Yes, indirect support can be inferred from the statement provided. Bronchopulmonary dysplasia (BPD) is characterized by chronic lung inflammation, alveolar enlargement, thickened alveolar septa, and small arteriolar wall thickening in newborns, particularly those born prematurely. The statement mentions that ibuprofen treatment in newborn rat pups led to reduced pulmonary vessel density, lung inflammation, alveolar enlargement, alveolar septum thickness, and small arteriolar wall thickening. By addressing these key features of BPD, ibuprofen may potentially alleviate symptoms associated with bronchopulmonary dysplasia. However, it is important to note that further investigation is required to establish a direct cause-and-effect relationship between ibuprofen use and improved BPD outcomes in humans, as animal studies may not fully capture all aspects of human disease pathophysiology." -22125431,Ibuprofen treats preeclampsia,1018,Introduction: The comparison of ibuprofen with acetaminophen for blood pressure (BP) in preeclampsia remains controversial.,False,Is the triple 'Ibuprofen treats preeclampsia' supported by the sentence: 'Introduction: The comparison of ibuprofen with acetaminophen for blood pressure (BP) in preeclampsia remains controversial.'?,"No, the statement does not provide indirect support for the phrase ""Ibuprofen treats preeclampsia."" The statement introduces a controversy surrounding the comparison of ibuprofen with acetaminophen for blood pressure in preeclampsia patients. However, it does not mention or imply that ibuprofen is an effective treatment for preeclampsia itself. It is essential to differentiate between addressing symptoms (blood pressure) and treating the condition (preeclampsia)." -21268743,Ibuprofen treats glioma,1019,"Taken together, our findings reveal that ibuprofen could induce ferroptosis of glioblastoma cells via downregulation of Nrf2 signaling pathway and is a potential drug for glioma treatment.",True,"Is the triple 'Ibuprofen treats glioma' supported by the sentence: 'Taken together, our findings reveal that ibuprofen could induce ferroptosis of glioblastoma cells via downregulation of Nrf2 signaling pathway and is a potential drug for glioma treatment.'?","Yes, the statement does provide indirect support for the phrase ""Ibuprofen treats glioma."" The statement suggests that ibuprofen can induce ferroptosis in glioblastoma cells (a type of glioma) by downregulating the Nrf2 signaling pathway. This implies that ibuprofen could potentially be used as a treatment for glioma, as it appears to have an effect on these cancerous cells. However, it is important to note that this is based on experimental findings in a specific context, and further research would be needed to confirm these results and evaluate the safety and efficacy of ibuprofen as a treatment for glioma in humans." -20821983,Ibuprofen treats common cold,1020,Ibuprofen (IBU) and phenylephrine hydrochloride (PE) were commonly used for common cold due to their different effects in relieving fever and the main symptoms such as nasal congestion and high sinus pressure.,False,Is the triple 'Ibuprofen treats common cold' supported by the sentence: 'Ibuprofen (IBU) and phenylephrine hydrochloride (PE) were commonly used for common cold due to their different effects in relieving fever and the main symptoms such as nasal congestion and high sinus pressure.'?,"No, the statement does not provide direct or indirect support for the phrase ""Ibuprofen treats common cold."" The statement mentions that Ibuprofen (IBU) is used for common cold symptoms such as fever reduction, but it does not imply that Ibuprofen treats the common cold itself. To claim that Ibuprofen treats the common cold, one would need evidence showing that Ibuprofen affects the underlying cause of the common cold (typically viral infections) rather than merely alleviating specific symptoms." -20285347,Ibuprofen treats periodontitis,1021,"Therefore, the objective of this study was to investigate the local delivery of the NSAIDs model drug ibuprofen to treat periodontitis using different types of gel formulations (hydrogel, oleogel, and bigel).",True,"Is the triple 'Ibuprofen treats periodontitis' supported by the sentence: 'Therefore, the objective of this study was to investigate the local delivery of the NSAIDs model drug ibuprofen to treat periodontitis using different types of gel formulations (hydrogel, oleogel, and bigel).'?","Yes, the statement does provide indirect support for the phrase ""Ibuprofen treats periodontitis"". The objective of the study explicitly mentions investigating the local delivery of ibuprofen as a treatment for periodontitis using various gel formulations (hydrogel, oleogel, and bigel). This implies that ibuprofen is being considered as a potential therapeutic agent for treating periodontitis in this study. However, it is important to note that direct support would require actual experimental results demonstrating ibuprofen's effectiveness in treating periodontitis, rather than simply stating its use as a model drug in an investigation." -19270581,Ibuprofen treats bone fracture,1022,Does the Use of Ibuprofen in Children with Extremity Fractures Increase their Risk for Bone Healing Complications?,False,Is the triple 'Ibuprofen treats bone fracture' supported by the sentence: 'Does the Use of Ibuprofen in Children with Extremity Fractures Increase their Risk for Bone Healing Complications?'?,"No, the statement ""Does the Use of Ibuprofen in Children with Extremity Fractures Increase their Risk for Bone Healing Complications?"" does not provide indirect support for the phrase ""Ibuprofen treats bone fracture."" In fact, it suggests quite the opposite. By asking if ibuprofen use increases the risk for bone healing complications, it implies that ibuprofen may have an effect on bone healing, which could be interpreted negatively in terms of treatment efficacy. However, it does not explicitly state that ibuprofen treats bone fractures, nor does it provide any evidence for such a claim. - - To provide indirect support for ""Ibuprofen treats bone fracture,"" one might point to studies showing that ibuprofen reduces inflammation and pain in fracture patients, thereby potentially improving their comfort and mobility during healing. But even then, ""treats"" is a strong word that implies a causative relationship between ibuprofen use and improved bone healing outcomes, which would require direct empirical evidence that is currently lacking in the provided statement." -17621968,Ibuprofen treats Cognitive impairment,1023,"Finally, anti-inflammatory drug ibuprofen ameliorated the peripheral surgical wounding-induced cognitive impairment in 18 month-old mice.",False,"Is the triple 'Ibuprofen treats Cognitive impairment' supported by the sentence: 'Finally, anti-inflammatory drug ibuprofen ameliorated the peripheral surgical wounding-induced cognitive impairment in 18 month-old mice.'?","No, the statement does not provide direct support for the claim that ibuprofen treats cognitive impairment in humans. The study was conducted on 18-month-old mice, which may not translate directly to humans, particularly given that cognitive impairment in mice may not be equivalent to cognitive impairment in humans. Additionally, an amelioration of surgical wounding-induced cognitive impairment is not equivalent to treating cognitive impairment caused by other factors. Therefore, while this study may suggest potential therapeutic avenues for further investigation, it does not provide definitive evidence that ibuprofen is an effective treatment for cognitive impairment in humans." -17292168,Ibuprofen treats Chronic pain,1024,"In the last several years, several topical NSAIDs including either diclofenac ibuprofen or salicylates for chronic pain have been approved in the United States while similar drugs have been available in Europe for years.",True,"Is the triple 'Ibuprofen treats Chronic pain' supported by the sentence: 'In the last several years, several topical NSAIDs including either diclofenac ibuprofen or salicylates for chronic pain have been approved in the United States while similar drugs have been available in Europe for years.'?","Yes, the statement does provide indirect support for the phrase ""Ibuprofen treats Chronic pain"". The given statement implies that topical NSAIDs such as diclofenac ibuprofen have been approved in the United States for treating chronic pain, suggesting that ibuprofen is an effective treatment for chronic pain. However, it is important to note that while this statement supports the efficacy of ibuprofen for treating chronic pain, it does not necessarily support the specific claim ""Ibuprofen treats Chronic pain"" without qualifications regarding dosage forms (topical vs oral), route of administration, side effects, etc. Therefore, further investigation would be required for more direct support of that particular phrasing." -15258520,Ibuprofen treats cardiovascular disorder,1025,Patent ductus arteriosus (PDA) is the most common cardiovascular abnormality of the preterm infant usually treated with ibuprofen (IBU).,False,Is the triple 'Ibuprofen treats cardiovascular disorder' supported by the sentence: 'Patent ductus arteriosus (PDA) is the most common cardiovascular abnormality of the preterm infant usually treated with ibuprofen (IBU).'?,"No, the statement ""Ibuprofen treats cardiovascular disorder"" does not receive direct support from ""Patent ductus arteriosus (PDA) is the most common cardiovascular abnormality of the preterm infant usually treated with ibuprofen (IBU)."" + The statement is actually asking whether the use of Ibuprofen in children with extremity fractures increases their risk for bone healing complications, which is quite different from claiming that Ibuprofen treats bone fractures. In fact, it implies that there might be potential negative effects associated with its use in this context. - + Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) commonly used for pain relief and reducing inflammation. While it can help manage pain associated with bone fractures, it does not actively treat or heal the fracture itself. Therefore, no supportive evidence is provided by this statement for the direct treatment claim. - The reason for my answer is that while it is true that ibuprofen is used in treating PDA (a cardiovascular abnormality), it does not necessarily mean that ibuprofen treats cardiovascular disorders in general. PDA is a specific condition that occurs in preterm infants due to incomplete closure of certain blood vessels after birth. Ibuprofen is used in managing PDA because it helps promote constriction of these blood vessels; however, its efficacy is limited to PDA cases and does not imply that ibuprofen is effective in treating other cardiovascular disorders. + It is essential to differentiate between pain management and treatment when discussing pharmaceutical interventions like Ibuprofen. Misinterpreting such statements could lead to inaccurate conclusions about therapeutic efficacy and" +17621968,Ibuprofen treats Cognitive impairment,1023,"Finally, anti-inflammatory drug ibuprofen ameliorated the peripheral surgical wounding-induced cognitive impairment in 18 month-old mice.",True,"'Does the phrase ""Ibuprofen treats Cognitive impairment"" receive at least indirect support from the statement: ""Finally, anti-inflammatory drug ibuprofen ameliorated the peripheral surgical wounding-induced cognitive impairment in 18 month-old mice.""?","Yes, indirectly it does lend some support. The statement suggests that ibuprofen treatment improved cognitive function in mice that had undergone peripheral surgical wounding. However, it's important to note that this is not a direct correlation between ibuprofen and cognitive impairment treatment in general. The cognitive impairment here is specifically related to surgical wounding in mice, which may not translate directly to other forms of cognitive impairment in different organisms, including humans. Therefore, while there is some indirect support for the claim, more extensive research would be needed to fully substantiate it." +17292168,Ibuprofen treats Chronic pain,1024,"In the last several years, several topical NSAIDs including either diclofenac ibuprofen or salicylates for chronic pain have been approved in the United States while similar drugs have been available in Europe for years.",True,"'Does the phrase ""Ibuprofen treats Chronic pain"" receive at least indirect support from the statement: ""In the last several years, several topical NSAIDs including either diclofenac ibuprofen or salicylates for chronic pain have been approved in the United States while similar drugs have been available in Europe for years.""?","Yes, the statement does provide indirect support for the phrase ""Ibuprofen treats Chronic pain"". The approval of topical NSAIDs (Non-Steroidal Anti-Inflammatory Drugs), including ibuprofen, for chronic pain in the United States suggests that these drugs have been found effective in treating chronic pain. This is further supported by the fact that similar drugs have been available in Europe for years, implying a long-standing recognition of their efficacy in treating chronic pain. However, it is important to note that while this statement supports the efficacy of ibuprofen in treating chronic pain, it does not provide direct evidence of such; further investigation would be required for a more definitive conclusion." +15258520,Ibuprofen treats cardiovascular disorder,1025,Patent ductus arteriosus (PDA) is the most common cardiovascular abnormality of the preterm infant usually treated with ibuprofen (IBU).,True,"'Does the phrase ""Ibuprofen treats cardiovascular disorder"" receive at least indirect support from the statement: ""Patent ductus arteriosus (PDA) is the most common cardiovascular abnormality of the preterm infant usually treated with ibuprofen (IBU).""?","Yes, while the statement does not explicitly say that ibuprofen treats cardiovascular disorders, it implies that ibuprofen is used in the treatment of PDA, which is a cardiovascular abnormality. This suggests that ibuprofen has some therapeutic value in treating cardiovascular conditions, thus providing indirect support for the claim that ibuprofen treats cardiovascular disorders. However, it is important to note that PDA is not a disorder in all contexts but rather a normal fetal circulation pathway that sometimes fails to close after birth in preterm infants. Therefore, the claim should be interpreted in a specific clinical context." +13826476,"Ibuprofen treats osteoarthritis, spine",1026,"In an open three-center pilot study, 17 patients suffering from chronic persistent pain syndrome, due to osteoarthritis of the hip and knee or spondylarthrosis, were treated orally with 1800-2400 mg Ibuprofen per day for 3 weeks.",True,"'Does the phrase ""Ibuprofen treats osteoarthritis, spine"" receive at least indirect support from the statement: ""In an open three-center pilot study, 17 patients suffering from chronic persistent pain syndrome, due to osteoarthritis of the hip and knee or spondylarthrosis, were treated orally with 1800-2400 mg Ibuprofen per day for 3 weeks.""?","Yes, the statement does provide indirect support for the phrase ""Ibuprofen treats osteoarthritis, spine"". The study mentions that 17 patients suffering from chronic persistent pain syndrome due to osteoarthritis of the hip and knee or spondylarthrosis were treated with Ibuprofen for 3 weeks. Spondylarthrosis is a type of osteoarthritis that affects the spine. Therefore, this study demonstrates that Ibuprofen was used to treat osteoarthritis in the spine, providing indirect evidence for the claim. However, it is important to note that this is an open three-center pilot study with a small sample size of 17 patients, which limits the generalizability of the results. Additionally, while pain relief is one of the symptoms alleviated by Ibuprofen in osteoarthritis patients, it does not necessarily imply that Ibuprofen treats osteoarthritis as a disease." +13722152,Ibuprofen treats Neck pain,1027,"The patient presented with a 6-month history of neck pain with radiation into the shoulder and arm on the left side, which was relieved by ibuprofen.",True,"'Does the phrase ""Ibuprofen treats Neck pain"" receive at least indirect support from the statement: ""The patient presented with a 6-month history of neck pain with radiation into the shoulder and arm on the left side, which was relieved by ibuprofen.""?","Yes, there is indirect support for the claim that ibuprofen treats neck pain based on the provided statement. The patient's history of neck pain lasting six months, which was subsequently relieved by taking ibuprofen, suggests that ibuprofen had an ameliorative effect on their neck pain symptoms. Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) that works by reducing hormones that cause inflammation and pain in the body. However, it is important to note that while this statement supports ibuprofen's efficacy in treating neck pain for this particular patient, it does not necessarily imply that ibuprofen will be an effective treatment for all individuals experiencing neck pain. Further studies would be required to establish its general efficacy for treating neck pain conditions." +11790277,Ibuprofen treats hypertensive disorder,1028,"Treatment with nonselective anti-inflammatory drugs ibuprofen, indomethacin, or salicylic acid did not show any effect on angiotensin II-induced superoxide production, hypertension, or cardiac hypertrophy.",False,"'Does the phrase ""Ibuprofen treats hypertensive disorder"" receive at least indirect support from the statement: ""Treatment with nonselective anti-inflammatory drugs ibuprofen, indomethacin, or salicylic acid did not show any effect on angiotensin II-induced superoxide production, hypertension, or cardiac hypertrophy.""?","No, the statement does not provide indirect support for the phrase ""Ibuprofen treats hypertensive disorder."" The study mentioned in the statement investigated the effects of nonselective anti-inflammatory drugs (ibuprofen, indomethacin, and salicylic acid) on angiotensin II-induced superoxide production, hypertension, and cardiac hypertrophy but found no significant effects of ibuprofen on these factors. - + The lack of observed effects on hypertension does not necessarily imply that ibuprofen cannot have any impact on hypertensive disorder treatment; however, it does not support such an assertion either. To establish whether ibuprofen treats hypertensive disorders indirectly based on this statement, we would need evidence of its efficacy in treating hypertension or related symptoms under specific conditions. - It is essential not to overgeneralize the therapeutic application of ibuprofen based on its use in treating PDA alone since cardiovascular disorders encompass various conditions affecting heart function and blood vessels requiring distinct treatment approaches. Consequently, it" -13826476,"Ibuprofen treats osteoarthritis, spine",1026,"In an open three-center pilot study, 17 patients suffering from chronic persistent pain syndrome, due to osteoarthritis of the hip and knee or spondylarthrosis, were treated orally with 1800-2400 mg Ibuprofen per day for 3 weeks.",True,"Is the triple 'Ibuprofen treats osteoarthritis, spine' supported by the sentence: 'In an open three-center pilot study, 17 patients suffering from chronic persistent pain syndrome, due to osteoarthritis of the hip and knee or spondylarthrosis, were treated orally with 1800-2400 mg Ibuprofen per day for 3 weeks.'?","Yes, indirectly it does lend support. The statement mentions that patients suffering from chronic persistent pain syndrome due to osteoarthritis of the hip and knee or spondylarthrosis were treated with Ibuprofen for three weeks. The fact that they were treated implies that Ibuprofen was used as a therapeutic agent for these conditions, which includes osteoarthritis of the spine (spondylarthrosis). However, it is important to note that this is an open pilot study involving only 17 patients, which is not a large enough sample size to make definitive conclusions about the efficacy of Ibuprofen for treating osteoarthritis in the spine based on this study alone." -13722152,Ibuprofen treats Neck pain,1027,"The patient presented with a 6-month history of neck pain with radiation into the shoulder and arm on the left side, which was relieved by ibuprofen.",True,"Is the triple 'Ibuprofen treats Neck pain' supported by the sentence: 'The patient presented with a 6-month history of neck pain with radiation into the shoulder and arm on the left side, which was relieved by ibuprofen.'?","Yes, the statement does provide indirect support for the phrase ""Ibuprofen treats Neck pain"". The patient's relief from neck pain upon taking ibuprofen suggests that ibuprofen has therapeutic effects on neck pain. However, it is important to note that this is an observational finding in one patient and does not constitute definitive proof due to lack of control, randomization, and potential for placebo effect. Further studies would be needed to confirm these observations and establish causality." -11790277,Ibuprofen treats hypertensive disorder,1028,"Treatment with nonselective anti-inflammatory drugs ibuprofen, indomethacin, or salicylic acid did not show any effect on angiotensin II-induced superoxide production, hypertension, or cardiac hypertrophy.",False,"Is the triple 'Ibuprofen treats hypertensive disorder' supported by the sentence: 'Treatment with nonselective anti-inflammatory drugs ibuprofen, indomethacin, or salicylic acid did not show any effect on angiotensin II-induced superoxide production, hypertension, or cardiac hypertrophy.'?","No, the statement does not provide indirect support for the claim that ""Ibuprofen treats hypertensive disorder."" In fact, it suggests the opposite: ibuprofen has no significant effect on hypertension (high blood pressure) in this specific study context involving angiotensin II-induced hypertension and cardiac hypertrophy. Therefore, one cannot infer that ibuprofen can treat hypertensive disorders based on these results alone. It is essential to consider that individual studies may have limitations in terms of their scope and applicability; thus, further evidence from other studies may be required for more definitive conclusions regarding ibuprofen's potential therapeutic effects on hypertension." -11536369,Ibuprofen treats seasonal allergic rhinitis,1029,Addition of ibuprofen to pseudoephedrine and chlorpheniramine in the treatment of seasonal allergic rhinitis.,True,Is the triple 'Ibuprofen treats seasonal allergic rhinitis' supported by the sentence: 'Addition of ibuprofen to pseudoephedrine and chlorpheniramine in the treatment of seasonal allergic rhinitis.'?,"Yes, the statement does provide indirect support for the claim that ibuprofen treats seasonal allergic rhinitis (SAR). The addition of ibuprofen to other medications like pseudoephedrine and chlorpheniramine in treating SAR implies that ibuprofen has some therapeutic effect on SAR symptoms, thus lending support to its use as a treatment for SAR. However, it is important to note that the claim is not directly supported by this statement since it does not explicitly state that ibuprofen alone treats SAR; it only implies its efficacy as an additive treatment component." -11381904,Ibuprofen treats Premature birth,1030,This should be considered to assess pharmacokinetic-pharmacodynamic relationships of ibuprofen in premature neonates and subsequently to understand and refine the use of ibuprofen in managing PDA either as a prophylactic or curative treatment.,False,Is the triple 'Ibuprofen treats Premature birth' supported by the sentence: 'This should be considered to assess pharmacokinetic-pharmacodynamic relationships of ibuprofen in premature neonates and subsequently to understand and refine the use of ibuprofen in managing PDA either as a prophylactic or curative treatment.'?,"No, the statement does not provide direct support for the claim that ""Ibuprofen treats Premature birth."" The statement discusses analyzing pharmacokinetic-pharmacodynamic relationships of ibuprofen in premature neonates and refining its use in managing Patent Ductus Arteriosus (PDA). While PDA is common in premature infants, treating PDA is not equivalent to treating premature birth itself. The statement focuses on understanding how ibuprofen works in premature neonates in order to optimize its use for treating PDA, not on treating prematurity itself." -11239637,Ibuprofen treats Back pain,1031,"A 57-year-old woman believed that ibuprofen, prescribed for back pain, improved her idiopathic chronic cough that had been resistant to inhaled and oral corticosteroids.",False,"Is the triple 'Ibuprofen treats Back pain' supported by the sentence: 'A 57-year-old woman believed that ibuprofen, prescribed for back pain, improved her idiopathic chronic cough that had been resistant to inhaled and oral corticosteroids.'?","No, the statement does not provide direct or indirect support for the claim that ibuprofen treats back pain based on the information about a patient with chronic cough. The woman's belief about her improvement is anecdotal evidence that cannot be generalized to support ibuprofen's effectiveness in treating back pain since her medical condition is unrelated. The statement only highlights the potential side effect of ibuprofen on chronic cough in one individual; it does not demonstrate its therapeutic effect on back pain. A rigorous clinical study would be required to make such a claim about ibuprofen treating back pain." -10195210,Ibuprofen treats influenza,1032,"A multicenter, randomized, double-blind, double-dummy, placebo- and active-controlled, parallel-group comparison of diclofenac-K and ibuprofen for the treatment of adults with influenza-like symptoms.",False,"Is the triple 'Ibuprofen treats influenza' supported by the sentence: 'A multicenter, randomized, double-blind, double-dummy, placebo- and active-controlled, parallel-group comparison of diclofenac-K and ibuprofen for the treatment of adults with influenza-like symptoms.'?","No, the statement does not provide direct or indirect support for the phrase ""Ibuprofen treats influenza."" The study mentioned is comparing diclofenac-K and ibuprofen for treating adults with influenza-like symptoms; however, it does not prove that ibuprofen can treat influenza itself. The study design is also investigating whether diclofenac-K is superior to ibuprofen in treating these symptoms, which indicates that ibuprofen may alleviate symptoms but may not necessarily target the influenza virus itself. - - Additionally, influenza-like symptoms can be caused by various factors such as common colds or other respiratory infections, not solely influenza viruses. Therefore, it is crucial not to jump to conclusions about ibuprofen treating influenza based on this statement alone. Further investigation and evidence would be required for such support." -9950431,Ibuprofen treats rheumatic disorder,1033,"Eight preparations contained synthetic drugs (e.g. benzodiazepines and tricyclic antidepressants in sedative preparations, cyproheptadine in a remedy to gain bodyweight, ibuprofen and dipyrone in herbal capsules used to treat rheumatism).",True,"Is the triple 'Ibuprofen treats rheumatic disorder' supported by the sentence: 'Eight preparations contained synthetic drugs (e.g. benzodiazepines and tricyclic antidepressants in sedative preparations, cyproheptadine in a remedy to gain bodyweight, ibuprofen and dipyrone in herbal capsules used to treat rheumatism).'?","Yes, the statement does provide indirect support for the phrase ""Ibuprofen treats rheumatic disorder"". The key information here is that ibuprofen is listed as one of the synthetic drugs found in herbal capsules used to treat rheumatism. This implies that ibuprofen is being used as a therapeutic agent in the treatment of rheumatic disorders, which aligns with the claim that ibuprofen treats rheumatic disorder. However, it is important to note that this is indirect evidence and does not constitute definitive proof on its own. It would be strengthened by additional evidence from clinical trials or other robust studies demonstrating ibuprofen's efficacy in treating rheumatic disorders." -9913360,Ibuprofen treats Myalgia,1034,Preliminary comparison of bromelain and Ibuprofen for delayed onset muscle soreness management.,True,Is the triple 'Ibuprofen treats Myalgia' supported by the sentence: 'Preliminary comparison of bromelain and Ibuprofen for delayed onset muscle soreness management.'?,"Yes, the statement does provide indirect support for the phrase ""Ibuprofen treats Myalgia"". Myalgia refers to muscle pain or inflammation, which is what is being discussed in the statement ""Preliminary comparison of bromelain and Ibuprofen for delayed onset muscle soreness management."" Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) known for its ability to reduce pain and inflammation, which aligns with the treatment of myalgia. However, it is important to note that while this statement suggests Ibuprofen can help manage symptoms associated with myalgia, it does not definitively prove that Ibuprofen treats myalgia. Further research would be needed to make such a claim." -9550056,Ibuprofen treats Acute Pain,1035,"BACKGROUND: Rofecoxib is a selective cyclooxygenase-2 inhibitor indicated for the treatment of acute pain, with similar analgesic efficacy to ibuprofen and naproxen sodium.",True,"Is the triple 'Ibuprofen treats Acute Pain' supported by the sentence: 'BACKGROUND: Rofecoxib is a selective cyclooxygenase-2 inhibitor indicated for the treatment of acute pain, with similar analgesic efficacy to ibuprofen and naproxen sodium.'?","Yes, the statement does provide indirect support for the phrase ""Ibuprofen treats Acute Pain"". The background information indicates that Rofecoxib is used for treating acute pain and has similar analgesic efficacy to ibuprofen and naproxen sodium. Since ibuprofen is mentioned alongside Rofecoxib as having similar pain-relieving properties, it can be inferred that ibuprofen does indeed treat acute pain. However, it is important to note that this is an indirect inference based on comparative efficacy to another proven treatment rather than direct evidence of ibuprofen's effectiveness in treating acute pain." -9536612,Ibuprofen treats Low back pain,1036,CONCLUSION: Continuous low-level heat wrap therapy was superior to both acetaminophen and ibuprofen for treating low back pain.,True,Is the triple 'Ibuprofen treats Low back pain' supported by the sentence: 'CONCLUSION: Continuous low-level heat wrap therapy was superior to both acetaminophen and ibuprofen for treating low back pain.'?,"Yes, the statement does provide indirect support for the phrase ""Ibuprofen treats Low back pain"". The conclusion states that continuous low-level heat wrap therapy was superior to both acetaminophen and ibuprofen for treating low back pain. However, it does imply that ibuprofen has some efficacy in treating low back pain, albeit not as effective as heat wrap therapy or continuous low-level heat wrap therapy in this particular study. Therefore, while it doesn't strongly support the statement, it does provide some level of indirect evidence that ibuprofen can help alleviate low back pain." -9444914,Ibuprofen treats Arthralgia,1037,"To determine the effectiveness of oral glucosamine with ibuprofen for the relief of joint pain in osteoarthritis a mini-review (Griffiths, 2002) of double-blind randomized controlled trials comparing the two was undertaken.",False,"Is the triple 'Ibuprofen treats Arthralgia' supported by the sentence: 'To determine the effectiveness of oral glucosamine with ibuprofen for the relief of joint pain in osteoarthritis a mini-review (Griffiths, 2002) of double-blind randomized controlled trials comparing the two was undertaken.'?","No, the statement does not provide direct or indirect support for the claim that ""Ibuprofen treats Arthralgia"". The mini-review discussed in the statement compares oral glucosamine with ibuprofen for relief in joint pain specifically related to osteoarthritis. Arthralgia is defined as joint pain in general and is not limited to osteoarthritis. Therefore, even though ibuprofen might be effective in alleviating joint pain in osteoarthritis as suggested by the review, it does not necessarily mean that ibuprofen is effective in treating arthralgia in all cases." -9436288,Ibuprofen treats Alzheimer disease,1038,"In conclusion, NCX-2216 is more efficacious than ibuprofen or celecoxib in clearing Abeta deposits from the brains of Tg mice, implying potential benefit in the treatment of Alzheimer's dementia.",False,"Is the triple 'Ibuprofen treats Alzheimer disease' supported by the sentence: 'In conclusion, NCX-2216 is more efficacious than ibuprofen or celecoxib in clearing Abeta deposits from the brains of Tg mice, implying potential benefit in the treatment of Alzheimer's dementia.'?","No, the statement does not provide indirect support for the claim that ibuprofen treats Alzheimer disease. The conclusion drawn in the statement is about NCX-2216 being more efficacious than ibuprofen in clearing Abeta deposits from Tg mice brains. While it suggests that NCX-2216 could be beneficial in treating Alzheimer's dementia due to its effectiveness in removing beta-amyloid deposits (a known hallmark of Alzheimer's disease), it does not imply that ibuprofen has any direct therapeutic effect on Alzheimer disease. - - To further clarify, let us examine the components in question: - - - NCX-2216 is shown to be more effective than ibuprofen in clearing Abeta deposits in Tg mice brains. - - A potential benefit in treating Alzheimer's dementia is implied for NCX-2216 due to its efficacy in removing these deposits (which is associated with Alzheimer's disease progression). - - Ibuprofen does not receive any direct support for treating Alzheimer disease since" -9104501,Ibuprofen treats injury,1039,"Ibuprofen attenuates early lung injury in endotoxemic, neutropenic rats.",False,"Is the triple 'Ibuprofen treats injury' supported by the sentence: 'Ibuprofen attenuates early lung injury in endotoxemic, neutropenic rats.'?","No, the statement ""Ibuprofen attenuates early lung injury in endotoxemic, neutropenic rats"" does not provide direct support for the claim ""Ibuprofen treats injury."" While it is true that ibuprofen has been shown to have an attenuating effect on early lung injury in specific experimental conditions (endotoxemic, neutropenic rats), it does not necessarily mean that ibuprofen can be universally applied as an injury treatment in all contexts. + It is essential to consider that ibuprofen is primarily an analgesic and anti-inflammatory drug; its potential benefits in treating hypertension might be related to its impact on inflammation rather than blood pressure regulation directly. Therefore, further investigation is required before making conclusions about ibuprofen as a treatment for" +11536369,Ibuprofen treats seasonal allergic rhinitis,1029,Addition of ibuprofen to pseudoephedrine and chlorpheniramine in the treatment of seasonal allergic rhinitis.,True,"'Does the phrase ""Ibuprofen treats seasonal allergic rhinitis"" receive at least indirect support from the statement: ""Addition of ibuprofen to pseudoephedrine and chlorpheniramine in the treatment of seasonal allergic rhinitis.""?","Yes, the statement does provide indirect support for the phrase ""Ibuprofen treats seasonal allergic rhinitis"". The statement suggests that ibuprofen is added to pseudoephedrine and chlorpheniramine for the treatment of seasonal allergic rhinitis. This implies that ibuprofen has some therapeutic effect on seasonal allergic rhinitis, otherwise it would not be included in the treatment regimen. However, it's important to note that this is an indirect inference and does not provide direct evidence of ibuprofen's effectiveness in treating seasonal allergic rhinitis. For a more definitive conclusion, clinical trials specifically testing ibuprofen as a treatment for seasonal allergic rhinitis would be needed." +11381904,Ibuprofen treats Premature birth,1030,This should be considered to assess pharmacokinetic-pharmacodynamic relationships of ibuprofen in premature neonates and subsequently to understand and refine the use of ibuprofen in managing PDA either as a prophylactic or curative treatment.,False,"'Does the phrase ""Ibuprofen treats Premature birth"" receive at least indirect support from the statement: ""This should be considered to assess pharmacokinetic-pharmacodynamic relationships of ibuprofen in premature neonates and subsequently to understand and refine the use of ibuprofen in managing PDA either as a prophylactic or curative treatment.""?","No, the statement does not provide direct support for the phrase ""Ibuprofen treats Premature birth."" The statement discusses assessing pharmacokinetic-pharmacodynamic relationships of ibuprofen in premature neonates and refining its use in managing Patent Ductus Arteriosus (PDA), which could be either prophylactic or curative treatment. However, it does not mention or imply that ibuprofen treats premature birth itself but rather focuses on its potential effects on PDA in premature neonates." +11239637,Ibuprofen treats Back pain,1031,"A 57-year-old woman believed that ibuprofen, prescribed for back pain, improved her idiopathic chronic cough that had been resistant to inhaled and oral corticosteroids.",False,"'Does the phrase ""Ibuprofen treats Back pain"" receive at least indirect support from the statement: ""A 57-year-old woman believed that ibuprofen, prescribed for back pain, improved her idiopathic chronic cough that had been resistant to inhaled and oral corticosteroids.""?","No, the statement does not provide direct or indirect support for the claim that ibuprofen treats back pain. The statement describes an observation of a 57-year-old woman who experienced an improvement in her chronic cough after taking ibuprofen prescribed for back pain. However, it does not establish a causal relationship between ibuprofen and back pain relief. The improvement in cough could be coincidental or related to an unknown factor. To support the claim that ibuprofen treats back pain, there should be evidence of its efficacy specifically for back pain symptoms from clinical trials or studies designed to test that hypothesis." +10195210,Ibuprofen treats influenza,1032,"A multicenter, randomized, double-blind, double-dummy, placebo- and active-controlled, parallel-group comparison of diclofenac-K and ibuprofen for the treatment of adults with influenza-like symptoms.",False,"'Does the phrase ""Ibuprofen treats influenza"" receive at least indirect support from the statement: ""A multicenter, randomized, double-blind, double-dummy, placebo- and active-controlled, parallel-group comparison of diclofenac-K and ibuprofen for the treatment of adults with influenza-like symptoms.""?","No, the statement does not provide indirect support for the phrase ""Ibuprofen treats influenza."" The study mentioned in the statement is comparing diclofenac-K and ibuprofen for treating adults with influenza-like symptoms, not proving that ibuprofen can treat influenza itself. The study might show that ibuprofen can help alleviate symptoms associated with influenza-like illnesses; however, it does not demonstrate that ibuprofen has antiviral properties against the influenza virus. Therefore, one cannot infer from this statement that ibuprofen is an effective treatment for influenza." +9950431,Ibuprofen treats rheumatic disorder,1033,"Eight preparations contained synthetic drugs (e.g. benzodiazepines and tricyclic antidepressants in sedative preparations, cyproheptadine in a remedy to gain bodyweight, ibuprofen and dipyrone in herbal capsules used to treat rheumatism).",True,"'Does the phrase ""Ibuprofen treats rheumatic disorder"" receive at least indirect support from the statement: ""Eight preparations contained synthetic drugs (e.g. benzodiazepines and tricyclic antidepressants in sedative preparations, cyproheptadine in a remedy to gain bodyweight, ibuprofen and dipyrone in herbal capsules used to treat rheumatism).""?","Yes, the statement does provide indirect support for the phrase ""Ibuprofen treats rheumatic disorder"". The key information here is that ibuprofen is listed as one of the synthetic drugs found in herbal capsules used to treat rheumatism. This implies that ibuprofen is being used as a therapeutic agent for rheumatic disorders, which aligns with the claim that ibuprofen can treat such conditions. However, it's important to note that this is an indirect inference based on the use of ibuprofen in a therapeutic context for rheumatism, rather than direct evidence of its efficacy in treating rheumatic disorders." +9913360,Ibuprofen treats Myalgia,1034,Preliminary comparison of bromelain and Ibuprofen for delayed onset muscle soreness management.,True,"'Does the phrase ""Ibuprofen treats Myalgia"" receive at least indirect support from the statement: ""Preliminary comparison of bromelain and Ibuprofen for delayed onset muscle soreness management.""?","Yes, indirect support can be inferred from the statement ""Preliminary comparison of bromelain and Ibuprofen for delayed onset muscle soreness management."" This implies that ibuprofen has been studied in relation to muscle soreness management, which includes myalgia (muscle pain). However, it is important to note that while this does provide some support for ibuprofen treating myalgia, it is not a direct claim that ibuprofen is effective for myalgia specifically. The context of the study design, results, and statistical significance would need to be evaluated for a more definitive conclusion about ibuprofen's effectiveness for myalgia." +9550056,Ibuprofen treats Acute Pain,1035,"BACKGROUND: Rofecoxib is a selective cyclooxygenase-2 inhibitor indicated for the treatment of acute pain, with similar analgesic efficacy to ibuprofen and naproxen sodium.",True,"'Does the phrase ""Ibuprofen treats Acute Pain"" receive at least indirect support from the statement: ""BACKGROUND: Rofecoxib is a selective cyclooxygenase-2 inhibitor indicated for the treatment of acute pain, with similar analgesic efficacy to ibuprofen and naproxen sodium.""?","Yes, the statement does provide indirect support for the phrase ""Ibuprofen treats Acute Pain"". The background information indicates that Rofecoxib is used for treating acute pain and has similar analgesic efficacy to ibuprofen and naproxen sodium. This implies that ibuprofen is also effective in treating acute pain since it has comparable efficacy to Rofecoxib in doing so. However, it is important to note that this is an indirect inference based on the comparative efficacy of Rofecoxib and ibuprofen; direct evidence of ibuprofen's effectiveness in treating acute pain would provide stronger support for the statement in question." +9536612,Ibuprofen treats Low back pain,1036,CONCLUSION: Continuous low-level heat wrap therapy was superior to both acetaminophen and ibuprofen for treating low back pain.,True,"'Does the phrase ""Ibuprofen treats Low back pain"" receive at least indirect support from the statement: ""CONCLUSION: Continuous low-level heat wrap therapy was superior to both acetaminophen and ibuprofen for treating low back pain.""?","Yes, the statement ""Continuous low-level heat wrap therapy was superior to both acetaminophen and ibuprofen for treating low back pain"" does provide indirect support for the claim that ""Ibuprofen treats low back pain."" This is because it suggests that ibuprofen does have some therapeutic effect on low back pain, even though it was found to be less effective than continuous low-level heat wrap therapy in this particular study. However, it is important to note that this does not mean that ibuprofen is the best treatment for low back pain, nor does it necessarily mean that it is superior to other treatments that were not tested in this study. It simply suggests that ibuprofen has some therapeutic benefit in treating low back pain." +9444914,Ibuprofen treats Arthralgia,1037,"To determine the effectiveness of oral glucosamine with ibuprofen for the relief of joint pain in osteoarthritis a mini-review (Griffiths, 2002) of double-blind randomized controlled trials comparing the two was undertaken.",False,"'Does the phrase ""Ibuprofen treats Arthralgia"" receive at least indirect support from the statement: ""To determine the effectiveness of oral glucosamine with ibuprofen for the relief of joint pain in osteoarthritis a mini-review (Griffiths, 2002) of double-blind randomized controlled trials comparing the two was undertaken.""?","No, the statement does not provide direct or indirect support for the claim ""Ibuprofen treats Arthralgia"". The mini-review mentioned in the statement focuses on comparing oral glucosamine and ibuprofen for relieving joint pain in osteoarthritis specifically. Arthralgia refers generally to joint pain, which can be caused by various factors beyond osteoarthritis. Thus, while it is plausible that ibuprofen could help alleviate arthralgia based on other evidence, this particular statement does not offer any relevant information regarding that specific claim." +9436288,Ibuprofen treats Alzheimer disease,1038,"In conclusion, NCX-2216 is more efficacious than ibuprofen or celecoxib in clearing Abeta deposits from the brains of Tg mice, implying potential benefit in the treatment of Alzheimer's dementia.",False,"'Does the phrase ""Ibuprofen treats Alzheimer disease"" receive at least indirect support from the statement: ""In conclusion, NCX-2216 is more efficacious than ibuprofen or celecoxib in clearing Abeta deposits from the brains of Tg mice, implying potential benefit in the treatment of Alzheimer's dementia.""?","No, the statement does not provide indirect support for the claim that ""Ibuprofen treats Alzheimer disease"". The conclusion drawn in the statement is about NCX-2216 being more efficacious than ibuprofen in clearing Abeta deposits from the brains of Tg mice, implying potential benefit in the treatment of Alzheimer's dementia. This suggests that NCX-2216 has better efficacy than ibuprofen in treating Alzheimer's disease-related pathology in mice model but does not indicate that ibuprofen itself is an effective treatment for Alzheimer disease in humans. - - The study referenced in the statement is limited in scope as it focuses on lung injury in rats under specific conditions (endotoxemic, neutropenic). Additionally, attenuation is not equivalent to treatment; attenuation implies that ibuprofen can reduce severity but may not necessarily eliminate injury altogether nor promote healing as one would expect from a treatment. + The statement specifically highlights that NCX-2216 is more effective than ibuprofen in treating Alzheimer-like pathology in mice model which does not necessarily translate into ibuprofen being an effective treatment for Alzheimer disease in humans as there might be various factors that could influence its efficacy in humans such as pharmacokinetics, safety profile, bioavailability etc. Therefore, it is not appropriate to infer from this statement that ibuprofen is an effective treatment for Alzheimer disease in humans." +9104501,Ibuprofen treats injury,1039,"Ibuprofen attenuates early lung injury in endotoxemic, neutropenic rats.",True,"'Does the phrase ""Ibuprofen treats injury"" receive at least indirect support from the statement: ""Ibuprofen attenuates early lung injury in endotoxemic, neutropenic rats.""?","Yes, the statement ""Ibuprofen attenuates early lung injury in endotoxemic, neutropenic rats"" does provide indirect support for the claim that ""Ibuprofen treats injury."" This is because ibuprofen is shown in this study to have a protective effect on lung tissue in rats that have been subjected to an endotoxin challenge under conditions of neutropenia (a state of reduced white blood cell count). This suggests that ibuprofen has therapeutic potential in treating lung injury in certain contexts, such as infections that induce an endotoxin response (a component of Gram-negative bacterial infections). - Therefore, based on the provided evidence, we cannot infer that ibuprofen treats injury in general but only that it might have some potential benefits in specific circumstances such as early lung injury under endotoxemic and neutropenic conditions in rats. Further studies would be required to" -8748381,Ibuprofen treats Dysmenorrhea,1040,CONCLUSION: Continuous low-level topical heat therapy was as effective as ibuprofen for the treatment of dysmenorrhea.,True,Is the triple 'Ibuprofen treats Dysmenorrhea' supported by the sentence: 'CONCLUSION: Continuous low-level topical heat therapy was as effective as ibuprofen for the treatment of dysmenorrhea.'?,"Yes, the statement does provide indirect support for the claim that ibuprofen treats dysmenorrhea (menstrual pain). The conclusion of the study indicates that continuous low-level topical heat therapy is as effective as ibuprofen for treating dysmenorrhea. This implies that ibuprofen is indeed an effective treatment for dysmenorrhea, as it is compared favorably against another effective treatment in the study. - However, it is important to note that while this study supports ibuprofen's effectiveness in treating dysmenorrhea relative to another treatment method, it does not provide direct evidence for ibuprofen being an absolute superior treatment compared to no treatment at all, nor does it compare ibuprofen against other pain relief medications for dysmenorrhea. Therefore, further studies would be required for more definitive conclusions regarding ibuprofen being the best treatment option for dysmenorrhea." -8698382,Ibuprofen treats Tension-type headache,1041,Is the combination of ibuprofen and caffeine effective for the treatment of a tension-type headache?,True,Is the triple 'Ibuprofen treats Tension-type headache' supported by the sentence: 'Is the combination of ibuprofen and caffeine effective for the treatment of a tension-type headache?'?,"Yes, there is indirect support for the phrase ""Ibuprofen treats Tension-type headache"" from the statement: ""Is the combination of ibuprofen and caffeine effective for the treatment of a tension-type headache?"" + However, it is important to note that while this finding supports ibuprofen as having beneficial effects on injury in specific contexts (i.e., endotoxin-induced lung injury in neutropenic rats), it does not necessarily mean that ibuprofen is effective in treating all types of injury in all organisms (including humans). Further studies would be needed to establish whether ibuprofen has similar protective effects in other models of injury and in humans before making more generalized" +8748381,Ibuprofen treats Dysmenorrhea,1040,CONCLUSION: Continuous low-level topical heat therapy was as effective as ibuprofen for the treatment of dysmenorrhea.,True,"'Does the phrase ""Ibuprofen treats Dysmenorrhea"" receive at least indirect support from the statement: ""CONCLUSION: Continuous low-level topical heat therapy was as effective as ibuprofen for the treatment of dysmenorrhea.""?","Yes, indirectly it does support the claim that ibuprofen treats dysmenorrhea (menstrual pain). The statement suggests that continuous low-level topical heat therapy is as effective as ibuprofen in treating dysmenorrhea. This implies that ibuprofen has a therapeutic effect on dysmenorrhea, thus supporting the claim that ibuprofen treats dysmenorrhea. However, it's important to note that this is indirect evidence, as it doesn't directly show ibuprofen treating dysmenorrhea, but rather its effectiveness compared to another treatment method." +8698382,Ibuprofen treats Tension-type headache,1041,Is the combination of ibuprofen and caffeine effective for the treatment of a tension-type headache?,True,"'Does the phrase ""Ibuprofen treats Tension-type headache"" receive at least indirect support from the statement: ""Is the combination of ibuprofen and caffeine effective for the treatment of a tension-type headache?""?","Yes, indirectly it does lend support. The statement ""Is the combination of ibuprofen and caffeine effective for the treatment of tension-type headache?"" implies that ibuprofen alone is also potentially effective for treating tension-type headaches, since caffeine is added as an adjuvant for increased efficacy in some formulations. However, it should be noted that while there is evidence supporting the use of ibuprofen for tension-type headaches, individual responses may vary; thus, further investigation is necessary for personalized treatment approaches." +8452594,Ibuprofen treats migraine disorder,1042,"Evaluation of a novel solubilized formulation of ibuprofen in the treatment of migraine headache: a randomized, double-blind, placebo-controlled, dose-ranging study.",True,"'Does the phrase ""Ibuprofen treats migraine disorder"" receive at least indirect support from the statement: ""Evaluation of a novel solubilized formulation of ibuprofen in the treatment of migraine headache: a randomized, double-blind, placebo-controlled, dose-ranging study.""?","Yes, the statement does provide indirect support for the phrase ""Ibuprofen treats migraine disorder."" The study mentioned is a randomized, double-blind, placebo-controlled, dose-ranging study - all of which are indicative of high-quality clinical research. The fact that ibuprofen was being evaluated specifically for its efficacy in treating migraine headaches suggests that it has some potential therapeutic benefit in managing symptoms of migraine disorder. However, it is important to note that this statement does not equate to a definitive claim that ibuprofen is a definitive treatment for migraine disorder; rather, it supports the notion that ibuprofen could be an effective management strategy for migraine symptoms based on the results of this particular study." +8420965,Ibuprofen treats Hemorrhage,1043,"A randomized trial measuring fecal blood loss after treatment with rofecoxib, ibuprofen, or placebo in healthy subjects.",False,"'Does the phrase ""Ibuprofen treats Hemorrhage"" receive at least indirect support from the statement: ""A randomized trial measuring fecal blood loss after treatment with rofecoxib, ibuprofen, or placebo in healthy subjects.""?","No, the statement ""Ibuprofen treats Hemorrhage"" does not receive at least indirect support from the provided statement ""A randomized trial measuring fecal blood loss after treatment with rofecoxib, ibuprofen, or placebo in healthy subjects."" - + The reason for this is that while the study does involve ibuprofen and measures an outcome that could be related to hemorrhage (fecal blood loss), it does not explicitly test or demonstrate that ibuprofen treats hemorrhage. The study is conducted in healthy subjects, which further limits its applicability to treating hemorrhage, a condition that typically occurs in individuals who are unwell. - The reason for my decision is that ibuprofen is an active ingredient in the combination treatment mentioned in the second statement. Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) that has been proven effective in relieving pain from tension-type headaches by reducing inflammation and pain signaling in the brain (Tfelt-Hansen et al., 2000). + Furthermore, even if the study had found that ibuprofen reduced fecal blood loss in healthy subjects, it would still not necessarily mean that ibuprofen treats hemorrhage. Hemorrhage is a complex condition that can occur in various parts of the body due to different causes, and it would require specific clinical trials to determine whether ibuprofen is effective in treating it in those contexts. - + Therefore, while such a study could potentially provide indirect evidence if it were designed differently (e" +8397426,Ibuprofen treats rheumatoid arthritis,1044,Ibuprofen or aspirin in rheumatoid arthritis therapy.,True,"'Does the phrase ""Ibuprofen treats rheumatoid arthritis"" receive at least indirect support from the statement: ""Ibuprofen or aspirin in rheumatoid arthritis therapy.""?","Yes, indirectly it does lend some support. The statement ""Ibuprofen or aspirin in rheumatoid arthritis therapy"" suggests that ibuprofen is used in the treatment of rheumatoid arthritis. However, it doesn't explicitly state that ibuprofen treats rheumatoid arthritis. It could be interpreted that ibuprofen is used as part of a therapeutic regimen for symptom management rather than as a direct treatment for the disease itself. Therefore, while not providing direct support, it does imply that ibuprofen is utilized in the context of rheumatoid arthritis therapy." +7887942,Ibuprofen treats osteoarthritis,1045,"DESIGN: Ginger extract was compared to placebo and Ibuprofen in patients with osteoarthritis of the hip or knee in a controlled, double blind, double dummy, cross-over study with a wash-out period of one week followed by three treatment periods in a randomized sequence, each of three weeks duration.",True,"'Does the phrase ""Ibuprofen treats osteoarthritis"" receive at least indirect support from the statement: ""DESIGN: Ginger extract was compared to placebo and Ibuprofen in patients with osteoarthritis of the hip or knee in a controlled, double blind, double dummy, cross-over study with a wash-out period of one week followed by three treatment periods in a randomized sequence, each of three weeks duration.""?","Yes, indirectly it does support the claim that ibuprofen treats osteoarthritis. The statement describes a study design where ibuprofen is being compared to placebo in patients with osteoarthritis of the hip or knee. This suggests that ibuprofen is being used as a treatment in this context. However, it doesn't provide direct evidence of ibuprofen's efficacy in treating osteoarthritis as it doesn't mention the outcomes of the study. It would be necessary to review the full study results for more direct support of ibuprofen treating osteoarthritis." +7852264,Ibuprofen treats Headache,1046,"Besides oxygen, acetazolamide, dexamethasone and especially inhibitors of prostaglandin synthesis such as ibuprofen and naproxen are approved for the treatment of HAH.",True,"'Does the phrase ""Ibuprofen treats Headache"" receive at least indirect support from the statement: ""Besides oxygen, acetazolamide, dexamethasone and especially inhibitors of prostaglandin synthesis such as ibuprofen and naproxen are approved for the treatment of HAH.""?","Yes, the phrase ""Ibuprofen treats Headache"" does receive indirect support from the statement provided. The statement mentions that ""inhibitors of prostaglandin synthesis such as ibuprofen and naproxen"" are approved for the treatment of HAH (High Altitude Headache). This implies that ibuprofen is effective in treating at least one type of headache, namely HAH, which is a form of headache. Therefore, it can be inferred that ibuprofen has therapeutic effects on headaches. However, it is important to note that headaches can be caused by various factors, and what works for one type may not work for another. Therefore, while there is indirect support for ibuprofen as a headache treatment, it is not universally applicable to all types of headaches without further investigation." +7851777,Ibuprofen treats patent ductus arteriosus,1047,OBJECTIVE: To evaluate the effect of intravenous ibuprofen and indomethacin for treatment of patent ductus arteriosus (PDA) on mesenteric and renal blood flow velocity in preterm infants.,True,"'Does the phrase ""Ibuprofen treats patent ductus arteriosus"" receive at least indirect support from the statement: ""OBJECTIVE: To evaluate the effect of intravenous ibuprofen and indomethacin for treatment of patent ductus arteriosus (PDA) on mesenteric and renal blood flow velocity in preterm infants.""?","Yes, indirectly it does lend support. The statement is an objective of a study that aims to evaluate the effect of intravenous ibuprofen on treating patent ductus arteriosus (PDA) in preterm infants. This implies that ibuprofen is being considered as a potential treatment for PDA, which aligns with the phrase ""Ibuprofen treats patent ductus arteriosus"". However, it is important to note that the study does not provide direct evidence of ibuprofen's effectiveness in treating PDA, but rather it is an objective of the study. Therefore, any conclusions about ibuprofen's effectiveness would need to be based on the results of the study once it is completed." +7732956,Ibuprofen treats Pain,1048,"The WOMAC detected significant differences between ibuprofen and placebo for pain and physical functioning, whereas the SF-36 detected differences for the bodily pain subscale.",True,"'Does the phrase ""Ibuprofen treats Pain"" receive at least indirect support from the statement: ""The WOMAC detected significant differences between ibuprofen and placebo for pain and physical functioning, whereas the SF-36 detected differences for the bodily pain subscale.""?","Yes, the statement does provide indirect support for the phrase ""Ibuprofen treats Pain"". The WOMAC (Western Ontario and McMaster Universities Osteoarthritis Index) study found significant differences between ibuprofen and placebo for pain and physical functioning. This indicates that ibuprofen has an impact on pain reduction compared to placebo, providing evidence that it can be used as an effective treatment for pain management. The SF-36 (Short Form Health Survey) study also supports ibuprofen's effect on pain as it detected differences in bodily pain subscale between ibuprofen and placebo groups. - Although the second statement refers to the combination of ibuprofen and caffeine as an effective treatment for tension-type headaches, it still implies that ibuprofen itself is an active component in managing such headaches. Therefore, it lends indirect support to the idea that ibuprofen can treat tension-type headaches. + However, it is important to note that while these studies suggest that ibuprofen can help alleviate pain symptoms in certain contexts (such as osteoarthritis), they do not necessarily imply that ibuprofen treats pain in all cases or conditions. Additionally, ibuprofen use may come with potential side effects such as gastrointestinal issues that should be considered when assessing its overall therapeutic value." +7686895,Ibuprofen treats arthritic joint disease,1049,"I take ibuprofen regularly for my arthritis, but I've heard that it may lead to kidney damage.",True,"'Does the phrase ""Ibuprofen treats arthritic joint disease"" receive at least indirect support from the statement: ""I take ibuprofen regularly for my arthritis, but I've heard that it may lead to kidney damage.""?","Yes, indirectly it does. The statement ""I take ibuprofen regularly for my arthritis"" suggests that the individual has found some relief from their arthritic joint disease through taking ibuprofen. This is because ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) commonly used for pain relief and reducing inflammation in conditions like arthritis. Therefore, it indirectly supports the claim that ibuprofen can help alleviate symptoms of arthritic joint disease. + However, the second part of the statement ""but I've heard that it may lead to kidney damage"" introduces a caveat that needs to be considered when using ibuprofen regularly for arthritis treatment. Long-term use of NSAIDs like ibuprofen has been linked with potential kidney damage due to their effect on renal blood flow and glomerular filtration rate (GFR). This should be taken into account when considering ibuprofen as a treatment option for arthritic joint disease, especially for individuals who have pre-existing kidney issues or other risk factors for kidney" +7258310,Ibuprofen treats Fever,1050,Paracetamol or ibuprofen in febrile children.,True,"'Does the phrase ""Ibuprofen treats Fever"" receive at least indirect support from the statement: ""Paracetamol or ibuprofen in febrile children.""?","Yes, the statement ""Paracetamol or ibuprofen in febrile children"" does provide indirect support for the claim ""Ibuprofen treats fever"". This is because ibuprofen is mentioned alongside paracetamol as an option for treating febrile children, implying that it has some effect on fever reduction. However, it should be noted that this does not constitute direct evidence of ibuprofen's efficacy in treating fever as it could also be inferred that both drugs are used for other symptoms associated with being febrile. To confirm the claim more rigorously, one would need to look at clinical trials or meta-analyses specifically investigating ibuprofen's impact on fever." +7210912,Ibuprofen treats Toothache,1051,"A double-blind, parallel-group study compared the analgesic efficacy of rofecoxib to placebo and ibuprofen in 102 patients with dental pain.",True,"'Does the phrase ""Ibuprofen treats Toothache"" receive at least indirect support from the statement: ""A double-blind, parallel-group study compared the analgesic efficacy of rofecoxib to placebo and ibuprofen in 102 patients with dental pain.""?","Yes, the statement ""Ibuprofen treats Toothache"" does receive indirect support from the provided statement about the double-blind study comparing rofecoxib, placebo, and ibuprofen in patients with dental pain. - However, it is essential to acknowledge that combining ibuprofen with caffeine may provide" -8452594,Ibuprofen treats migraine disorder,1042,"Evaluation of a novel solubilized formulation of ibuprofen in the treatment of migraine headache: a randomized, double-blind, placebo-controlled, dose-ranging study.",True,"Is the triple 'Ibuprofen treats migraine disorder' supported by the sentence: 'Evaluation of a novel solubilized formulation of ibuprofen in the treatment of migraine headache: a randomized, double-blind, placebo-controlled, dose-ranging study.'?","Yes, the statement does provide indirect support for the phrase ""Ibuprofen treats migraine disorder"". The study mentioned is a randomized, double-blind, placebo-controlled, dose-ranging study - all of which indicate that it was conducted in a rigorous and unbiased manner. The fact that it specifically investigates the use of ibuprofen in treating migraine headaches suggests that there is some basis for believing that ibuprofen could be an effective treatment for migraines. However, it's important to note that this is indirect support. The study itself does not prove that ibuprofen treats migraine disorder, but it does suggest that further investigation into this potential treatment is warranted." -8420965,Ibuprofen treats Hemorrhage,1043,"A randomized trial measuring fecal blood loss after treatment with rofecoxib, ibuprofen, or placebo in healthy subjects.",False,"Is the triple 'Ibuprofen treats Hemorrhage' supported by the sentence: 'A randomized trial measuring fecal blood loss after treatment with rofecoxib, ibuprofen, or placebo in healthy subjects.'?","No, the statement ""Ibuprofen treats Hemorrhage"" does not receive direct or indirect support from the provided randomized trial statement. The study measures fecal blood loss after treatment with rofecoxib, ibuprofen, or placebo in healthy subjects but it does not provide evidence that ibuprofen treats hemorrhage in patients who experience it. The study is testing for differences in fecal blood loss between these groups in healthy individuals who may not have hemorrhage conditions at all. + The reason for my affirmative answer lies in the design of the study itself. It is double-blind and parallel-group, which suggests that it adheres to rigorous standards aimed at minimizing bias in clinical trials. The study compares three interventions for dental pain - rofecoxib (a non-steroidal anti-inflammatory drug), placebo (an inactive treatment), and ibuprofen (another non-steroidal anti-inflammatory drug). - To support the claim that ""Ibuprofen treats Hemorrhage"", there would need to be specific evidence showing that ibuprofen reduces hemorrhage in patients suffering from it compared to either placebo or other treatments in controlled clinical trials designed explicitly for that purpose. A study measuring fecal blood loss in healthy individuals does not provide sufficient evidence for that claim due to differences in contexts, patient populations, and outcomes being evaluated." -8397426,Ibuprofen treats rheumatoid arthritis,1044,Ibuprofen or aspirin in rheumatoid arthritis therapy.,True,Is the triple 'Ibuprofen treats rheumatoid arthritis' supported by the sentence: 'Ibuprofen or aspirin in rheumatoid arthritis therapy.'?,"Yes, indirectly it does lend some support to the claim that ibuprofen treats rheumatoid arthritis. The statement ""Ibuprofen or aspirin in rheumatoid arthritis therapy"" suggests that both ibuprofen and aspirin are used in treating rheumatoid arthritis symptoms. This implies that ibuprofen has therapeutic effects on rheumatoid arthritis as it is recognized as an option for treatment within rheumatoid arthritis therapy. + While the study does not explicitly state that ibuprofen treats toothache, it does so implicitly by including it in a study that is designed to determine which interventions alleviate dental pain more effectively than others. By comparing ibuprofen against both an active treatment (rofecoxib) and placebo (an inactive treatment), it provides an opportunity for ibuprofen's efficacy in treating dental pain to" +25984950,Cefmenoxime treats bacterial infectious disease,1052,Cefmenoxime versus cefoxitin in the treatment of serious bacterial infections.,True,"'Does the phrase ""Cefmenoxime treats bacterial infectious disease"" receive at least indirect support from the statement: ""Cefmenoxime versus cefoxitin in the treatment of serious bacterial infections.""?","Yes, the phrase ""Cefmenoxime treats bacterial infectious disease"" does receive indirect support from the statement ""Cefmenoxime versus cefoxitin in the treatment of serious bacterial infections."" This is because the comparison study implies that Cefmenoxime is being used to treat serious bacterial infections, thereby providing evidence that it can be used for treating bacterial infectious diseases. However, it is important to note that direct support would require more specific information about the efficacy and safety of Cefmenoxime in treating bacterial infections compared to other treatments or no treatment at all." +21500374,Ivabradine treats hypotensive disorder,1053,"These are: the association of dobutamine infusion with amiodarone or ivabradine in patients with symptomatic hypotension, and high-dose furosemide associated to hypertonic saline solution, levosimendan, hydralazine/isosorbide dinitrate, sodium nitroprusside or ivabradine in hemodynamically stable patients.",True,"'Does the phrase ""Ivabradine treats hypotensive disorder"" receive at least indirect support from the statement: ""These are: the association of dobutamine infusion with amiodarone or ivabradine in patients with symptomatic hypotension, and high-dose furosemide associated to hypertonic saline solution, levosimendan, hydralazine/isosorbide dinitrate, sodium nitroprusside or ivabradine in hemodynamically stable patients.""?","Yes, the statement does provide indirect support for the phrase ""Ivabradine treats hypotensive disorder."" The statement lists ivabradine as one of the treatments associated with symptomatic hypotension when used in combination with dobutamine infusion. This implies that ivabradine is being used as an intervention for hypotension in this context. However, it is important to note that hypotension in this case may be an adverse effect of dobutamine infusion rather than the primary condition being treated by ivabradine. Additionally, ivabradine is also mentioned in relation to hemodynamically stable patients receiving high-dose furosemide associated with hypertonic saline solution, levosimendan, hydralazine/isosorbide dinitrate, sodium nitroprusside or ivabradine itself. This suggests that ivabradine is being used in these cases as part of a broader treatment strategy for managing hypotensive disorder in certain patient populations. However, without further information on dosage, patient outcomes, and specific clinical scenarios, it is difficult to draw definitive conclusions about ivabradine's efficacy in treating hypotensive" +18841652,Ivabradine treats toxic shock syndrome,1054,If Channel Inhibition With Ivabradine Does Not Improve Cardiac and Vascular Function in Experimental Septic Shock.,False,"'Does the phrase ""Ivabradine treats toxic shock syndrome"" receive at least indirect support from the statement: ""If Channel Inhibition With Ivabradine Does Not Improve Cardiac and Vascular Function in Experimental Septic Shock.""?","No, the statement ""If Channel Inhibition With Ivabradine Does Not Improve Cardiac and Vascular Function in Experimental Septic Shock"" does not provide indirect support for the claim that ""Ivabradine treats toxic shock syndrome"". The statement is actually negatively framed, suggesting that ivabradine does not have beneficial effects on cardiac and vascular function in experimental septic shock. Septic shock is a severe form of sepsis that can lead to tissue damage, organ failure, and death; it is not equivalent to toxic shock syndrome (TSS), which is a distinct condition typically caused by certain strains of Staphylococcus aureus or Streptococcus pyogenes bacteria that produce exotoxins leading to shock. While both conditions involve dysfunction of the cardiovascular system, they have different underlying causes and may require different treatment approaches. Therefore, evidence of ivabradine's effectiveness in one condition does not necessarily imply its efficacy in another." +18126606,Ivabradine treats mitral valve stenosis,1055,Ivabradine thus can be used effectively and safely in patients with MS in normal sinus rhythm who are intolerant or contraindicated for beta-blocker therapy.,False,"'Does the phrase ""Ivabradine treats mitral valve stenosis"" receive at least indirect support from the statement: ""Ivabradine thus can be used effectively and safely in patients with MS in normal sinus rhythm who are intolerant or contraindicated for beta-blocker therapy.""?","No, the phrase ""Ivabradine treats mitral valve stenosis"" does not receive indirect support from the statement provided. The statement suggests that Ivabradine can be used effectively and safely in patients with mitral valve stenosis (MS) who have normal sinus rhythm and cannot tolerate or are contraindicated for beta-blocker therapy. However, it does not imply that Ivabradine treats mitral valve stenosis itself. Instead, it indicates that Ivabradine is an alternative treatment option for managing heart rate in these specific patients with MS." +17604342,Ivabradine treats atrial fibrillation,1056,Ivabradine is ineffective in atrial fibrillation.,False,"'Does the phrase ""Ivabradine treats atrial fibrillation"" receive at least indirect support from the statement: ""Ivabradine is ineffective in atrial fibrillation.""?","No, the statement ""Ivabradine is ineffective in atrial fibrillation"" does not provide indirect support for the phrase ""Ivabradine treats atrial fibrillation."" In fact, it suggests quite the opposite. The word ""ineffective"" implies that ivabradine does not have a positive impact on atrial fibrillation, which contradicts the claim that ivabradine treats this condition. It is important to note that ""ineffective"" does not mean that ivabradine causes harm in atrial fibrillation; it simply means that it does not provide beneficial effects. Therefore, based on this statement alone, there is no support for the idea that ivabradine is used to treat atrial fibrillation." +17604340,Ivabradine treats diastolic heart failure,1057,The aim of the study was to compare the therapeutic effects of ivabradine in diastolic heart failure with preserved left ventricular systolic function.,True,"'Does the phrase ""Ivabradine treats diastolic heart failure"" receive at least indirect support from the statement: ""The aim of the study was to compare the therapeutic effects of ivabradine in diastolic heart failure with preserved left ventricular systolic function.""?","Yes, based on the provided statement, there is indirect support for the phrase ""Ivabradine treats diastolic heart failure."" The statement indicates that a study was conducted specifically to compare the therapeutic effects of ivabradine in diastolic heart failure with preserved left ventricular systolic function. This implies that ivabradine was being tested as a potential treatment for diastolic heart failure, suggesting that there is some basis for associating ivabradine with the treatment of diastolic heart failure. However, it is important to note that indirect support does not equate to definitive proof of efficacy, as further information about the study outcomes would be necessary to make such a determination." +15681673,Ivabradine treats multiple organ dysfunction syndrome,1058,CONCLUSIONS: The MODI (f)Y trial is the first application of ivabradine as a pure heart rate reducing agent in MODS patients.,True,"'Does the phrase ""Ivabradine treats multiple organ dysfunction syndrome"" receive at least indirect support from the statement: ""CONCLUSIONS: The MODI (f)Y trial is the first application of ivabradine as a pure heart rate reducing agent in MODS patients.""?","Yes, indirectly it does lend some support. The statement ""The MODI (f)Y trial is the first application of ivabradine as a pure heart rate reducing agent in MODS patients"" implies that ivabradine has been used in a trial involving Multiple Organ Dysfunction Syndrome (MODS) patients specifically for its heart rate reducing properties. This suggests that there may be some potential benefit in using ivabradine for treating MODS patients, although it does not explicitly state that ivabradine treats MODS. Therefore, while not direct evidence of treatment efficacy, it does provide some level of indirect support for further investigation into ivabradine's potential therapeutic effects on MODS patients." +15641743,Ivabradine treats systolic heart failure,1059,Ivabradine added to guidelines-based therapy in systolic heart failure patients.,True,"'Does the phrase ""Ivabradine treats systolic heart failure"" receive at least indirect support from the statement: ""Ivabradine added to guidelines-based therapy in systolic heart failure patients.""?","Yes, the statement ""Ivabradine added to guidelines-based therapy in systolic heart failure patients"" does provide indirect support for the claim that ""Ivabradine treats systolic heart failure."" This is because it implies that ivabradine is being used as part of a treatment regimen for systolic heart failure patients who are already receiving guideline-based therapy. However, it does not directly confirm that ivabradine is solely responsible for treating systolic heart failure; it could be part of a larger treatment plan that includes other therapies. Furthermore, while ivabradine may be used in the treatment of systolic heart failure, it does not necessarily mean that it is effective in treating systolic heart failure, as efficacy would need to be demonstrated through clinical trials and subsequent analysis of their results." +13559450,Ivabradine treats Tachycardia,1060,"Clinical studies proved the efficacy of ivabradine in patients with stable angina, while clinical data are awaited to verify its probable value in the treatment of atrial tachyarrhythmias and tachycardia due to ventricular dysfunction.",True,"'Does the phrase ""Ivabradine treats Tachycardia"" receive at least indirect support from the statement: ""Clinical studies proved the efficacy of ivabradine in patients with stable angina, while clinical data are awaited to verify its probable value in the treatment of atrial tachyarrhythmias and tachycardia due to ventricular dysfunction.""?","Yes, there is indirect support for the claim that ""Ivabradine treats Tachycardia"" based on the provided statement. - + The statement mentions that clinical studies have proven the efficacy of Ivabradine in patients with stable angina. While it does not explicitly state that Ivabradine treats tachycardia, it implies that Ivabradine may have value in treating atrial tachyarrhythmias and tachycardia due to ventricular dysfunction, as these conditions are specifically mentioned as areas where clinical data is being awaited. - However, it is important to note that while ibuprofen may alleviate symptoms in rheumatoid arthritis patients, it does not necessarily mean it treats the underlying cause of the disease. Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) that helps reduce pain, inflammation, and fever in patients; thus its use is primarily aimed at managing symptoms rather than addressing the root cause of rheumatoid arthritis. + However, it is important to note that while there is indirect support for this claim based on the statement provided, direct evidence of Ivabradine's efficacy in treating tachycardia is not presented in the statement. Therefore, further investigation would be necessary to definitively conclude that Ivabradine treats tachycardia." +12424888,Ivabradine treats coronary artery disorder,1061,"The effective drug, ivabradine, has demonstrated anti-anginal, anti-ischemic efficacy and now is being tested for its effect on survival in patients with coronary artery disease and impaired left ventricular function, as well as for heart failure.",True,"'Does the phrase ""Ivabradine treats coronary artery disorder"" receive at least indirect support from the statement: ""The effective drug, ivabradine, has demonstrated anti-anginal, anti-ischemic efficacy and now is being tested for its effect on survival in patients with coronary artery disease and impaired left ventricular function, as well as for heart failure.""?","Yes, while the statement does not explicitly claim that ivabradine treats coronary artery disorder, it does provide indirect support for that notion. The statement indicates that ivabradine has demonstrated anti-anginal (against chest pain) and anti-ischemic (against insufficient blood supply) efficacy in patients with coronary artery disease (a type of coronary artery disorder). Furthermore, it mentions that ivabradine is being tested for its effect on survival in patients with coronary artery disease and impaired left ventricular function, as well as for heart failure. The broader context of these investigations suggests that ivabradine could have beneficial effects in treating coronary artery disorder by alleviating symptoms (anti-anginal and anti-ischemic efficacy) and potentially improving survival rates in affected patients. However, it is essential to emphasize that further investigation is necessary to establish the precise therapeutic benefits of ivabradine in treating coronary artery disorder since the statement only provides preliminary evidence of its potential efficacy in that regard." +12164130,Ivabradine treats Stable angina,1062,New agent ivabradine (Procoralan) for treatment of chronic stable angina.,True,"'Does the phrase ""Ivabradine treats Stable angina"" receive at least indirect support from the statement: ""New agent ivabradine (Procoralan) for treatment of chronic stable angina.""?","Yes, the phrase ""Ivabradine treats Stable angina"" does receive indirect support from the statement: ""New agent ivabradine (Procoralan) for treatment of chronic stable angina."" - + The statement suggests that Ivabradine is a new agent being used in the treatment of chronic stable angina. This implies that Ivabradine has been found to be effective in treating chronic stable angina, thus providing indirect support for the claim that ""Ivabradine treats Stable angina."" However, it should be noted that this is an indirect inference and the statement does not explicitly state that Ivabradine treats stable angina. For a more direct support, a study or clinical trial report showing the efficacy of Ivabradine in treating stable angina would be required." +11342280,Ivabradine treats cardiovascular disorder,1063,Heart rate lowering by specific and selective I(f) current inhibition with ivabradine: a new therapeutic perspective in cardiovascular disease.,True,"'Does the phrase ""Ivabradine treats cardiovascular disorder"" receive at least indirect support from the statement: ""Heart rate lowering by specific and selective I(f) current inhibition with ivabradine: a new therapeutic perspective in cardiovascular disease.""?","Yes, the statement does provide indirect support for the phrase ""Ivabradine treats cardiovascular disorder."" The statement suggests that ivabradine has a specific and selective inhibitory effect on I(f) current, which is associated with heart rate regulation. By doing so, it offers a new therapeutic perspective in cardiovascular disease management. This implies that ivabradine may play a role in treating cardiovascular disorders by targeting heart rate regulation through I(f) current inhibition. However, it is important to note that further investigation would be necessary to establish direct causality and elucidate specific mechanisms of action involved in treating cardiovascular disorders with ivabradine." +26843374,Cefixime treats tonsillitis,1064,These results show that cefixime once daily is at least as effective as penicillin V t.i.d. in pharyngitis and tonsillitis in children.,True,"'Does the phrase ""Cefixime treats tonsillitis"" receive at least indirect support from the statement: ""These results show that cefixime once daily is at least as effective as penicillin V t.i.d. in pharyngitis and tonsillitis in children.""?","Yes, the phrase ""Cefixime treats tonsillitis"" does receive indirect support from the statement provided. The statement indicates that Cefixime is at least as effective as Penicillin V in treating pharyngitis and tonsillitis in children when used once daily. This implies that Cefixime has therapeutic effects on tonsillitis, thus providing indirect support for the claim that Cefixime treats tonsillitis. However, it is important to note that direct causality cannot be inferred from this statement alone; further evidence would be needed for a definitive conclusion about Cefixime's effectiveness in treating tonsillitis specifically." +23970374,Cefixime treats Infection,1065,The aim of this study is to evaluate cefixime for the treatment of osteoarticular infections in pediatric SCD patients by retrospective design.,True,"'Does the phrase ""Cefixime treats Infection"" receive at least indirect support from the statement: ""The aim of this study is to evaluate cefixime for the treatment of osteoarticular infections in pediatric SCD patients by retrospective design.""?","Yes, the phrase ""Cefixime treats infection"" does receive indirect support from the statement provided. The study aims to evaluate cefixime for treating osteoarticular infections in pediatric patients with sickle cell disease (SCD). This implies that cefixime is being considered as a potential treatment for infection in these patients. Therefore, it suggests that cefixime has some theoretical basis for treating infections, even though the statement does not explicitly confirm that cefixime treats infection. However, it is important to note that further evidence from the study itself would be needed to confirm its efficacy in treating infections in pediatric SCD patients specifically." +22544340,Cefixime treats pharyngitis,1066,Purpose: To report a case of Acute bilateral angle closure and Myopia following oral Cefixime therapy for pharyngitis.,False,"'Does the phrase ""Cefixime treats pharyngitis"" receive at least indirect support from the statement: ""Purpose: To report a case of Acute bilateral angle closure and Myopia following oral Cefixime therapy for pharyngitis.""?","No, the statement ""Purpose: To report a case of Acute bilateral angle closure and Myopia following oral Cefixime therapy for pharyngitis"" does not provide direct or indirect support for the claim ""Cefixime treats pharyngitis."" - In conclusion, although not definitive proof nor a direct statement about" -7887942,Ibuprofen treats osteoarthritis,1045,"DESIGN: Ginger extract was compared to placebo and Ibuprofen in patients with osteoarthritis of the hip or knee in a controlled, double blind, double dummy, cross-over study with a wash-out period of one week followed by three treatment periods in a randomized sequence, each of three weeks duration.",True,"Is the triple 'Ibuprofen treats osteoarthritis' supported by the sentence: 'DESIGN: Ginger extract was compared to placebo and Ibuprofen in patients with osteoarthritis of the hip or knee in a controlled, double blind, double dummy, cross-over study with a wash-out period of one week followed by three treatment periods in a randomized sequence, each of three weeks duration.'?","Yes, the statement does provide indirect support for the phrase ""Ibuprofen treats osteoarthritis"". The reason is that the study design described involves comparing ibuprofen to placebo in patients suffering from osteoarthritis of the hip or knee. By comparing an active treatment (ibuprofen) against an inactive treatment (placebo), researchers aim to determine whether ibuprofen has an effect on osteoarthritis symptoms beyond what could be attributed to chance or bias. + The statement in question is a case report of an adverse reaction following the use of Cefixime for pharyngitis treatment. It does not provide any information about the efficacy of Cefixime in treating pharyngitis. Therefore, it does not support the claim that Cefixime is an effective treatment for pharyngitis. - However, it is important to note that while this study design can help establish whether ibuprofen is effective in treating osteoarthritis relative to placebo, it does not necessarily prove that ibuprofen treats osteoarthritis in an absolute sense. To make that claim, one would need additional evidence from other studies that investigate ibuprofen's efficacy in treating osteoarthritis compared to no treatment at all. + Cefixime is an antibiotic that is often used to treat various bacterial infections, including pharyngitis caused by Group A Streptococcus (GAS). However, the statement does not provide any evidence about the bacterial cause of the pharyngitis case in question, nor does it report on the outcome of the treatment in terms of symptom resolution or bacterial eradication. Therefore, it does not contribute to our understanding of Cefixime's therapeutic effect in treating pharyngitis." +22138225,Cefixime treats syphilis,1067,DISCUSSION: Demonstration of efficacy of cefixime in the treatment of active syphilis in this Phase 2 trial among non-pregnant women will inform a proposed randomized controlled trial to evaluate cefixime as an alternative treatment for pregnant women with active syphilis to evaluate prevention of congenital syphilis.,True,"'Does the phrase ""Cefixime treats syphilis"" receive at least indirect support from the statement: ""DISCUSSION: Demonstration of efficacy of cefixime in the treatment of active syphilis in this Phase 2 trial among non-pregnant women will inform a proposed randomized controlled trial to evaluate cefixime as an alternative treatment for pregnant women with active syphilis to evaluate prevention of congenital syphilis.""?","Yes, the statement does provide indirect support for the phrase ""Cefixime treats syphilis."" The discussion mentions a Phase 2 trial demonstrating the efficacy of cefixime in treating active syphilis in non-pregnant women. This implies that cefixime has shown positive results in treating syphilis, thus lending credence to the idea that cefixime can be used to treat syphilis. However, it is important to note that this is indirect support; a Phase 2 trial typically does not provide definitive evidence of efficacy, and further research in a larger, randomized controlled trial is needed to confirm these findings. Additionally, the trial mentioned is specifically focused on non-pregnant women, so any extrapolation to other populations should be made with caution." +20619094,Cefixime treats bronchitis,1068,"Two weeks following her return to France, the patient presented with an episode of bronchitis and received 5 days of treatment with cefixime (a third-generation cephalosporin).",False,"'Does the phrase ""Cefixime treats bronchitis"" receive at least indirect support from the statement: ""Two weeks following her return to France, the patient presented with an episode of bronchitis and received 5 days of treatment with cefixime (a third-generation cephalosporin).""?","No, the statement ""Two weeks following her return to France, the patient presented with an episode of bronchitis and received 5 days of treatment with cefixime (a third-generation cephalosporin)"" does not provide direct or indirect support for the phrase ""Cefixime treats bronchitis."" This is because correlation does not imply causation - even though the patient received cefixime during her bout of bronchitis, it does not necessarily mean that cefixime was responsible for treating her bronchitis. It is possible that her bronchitis resolved on its own or was resolved by other treatments concurrently administered but not mentioned in the statement. To establish that cefixime treats bronchitis, controlled clinical trials would be required that demonstrate both safety and efficacy in treating bronchitis patients compared to placebo groups." +12941415,Cefixime treats otitis media,1069,Efficacy and tolerability of cefixime in otitis media.,True,"'Does the phrase ""Cefixime treats otitis media"" receive at least indirect support from the statement: ""Efficacy and tolerability of cefixime in otitis media.""?","Yes, the statement ""Efficacy and tolerability of cefixime in otitis media"" does provide indirect support for the claim that ""Cefixime treats otitis media."" The term ""efficacy"" implies that cefixime has a positive effect on otitis media, which aligns with the concept of treating the condition. However, it is important to note that direct support would require more specific language indicating causation between cefixime use and improvement in otitis media symptoms. Additionally, ""tolerability"" refers to how well patients can tolerate the drug, not its effectiveness in treating otitis media. Therefore, while there is some level of support for the claim based on this statement, it is not definitive proof of cefixime's ability to treat otitis media." +8827692,Cefixime treats gonorrhea,1070,A randomized trial of ciprofloxacin versus cefixime for treatment of gonorrhea after rapid emergence of gonococcal ciprofloxacin resistance in The Philippines.,True,"'Does the phrase ""Cefixime treats gonorrhea"" receive at least indirect support from the statement: ""A randomized trial of ciprofloxacin versus cefixime for treatment of gonorrhea after rapid emergence of gonococcal ciprofloxacin resistance in The Philippines.""?","Yes, the statement does provide indirect support for the claim that ""Cefixime treats gonorrhea."" The randomized trial mentioned in the statement is comparing two different treatments for gonorrhea - ciprofloxacin and cefixime. The fact that cefixime is being used in a trial for treating gonorrhea suggests that it has some efficacy in treating this infection. However, it's important to note that indirect support does not equate to definitive proof. The effectiveness of cefixime in treating gonorrhea would need to be evaluated in the context of its specific treatment guidelines, potential side effects, and resistance patterns." +7594422,Cefixime treats bacterial infectious disease,1071,A randomized controlled clinical study of cefetamet pivoxil (CAT) compared with cefixime (CFX) was conducted to evaluate its safety and efficacy in treating bacterial infections.,True,"'Does the phrase ""Cefixime treats bacterial infectious disease"" receive at least indirect support from the statement: ""A randomized controlled clinical study of cefetamet pivoxil (CAT) compared with cefixime (CFX) was conducted to evaluate its safety and efficacy in treating bacterial infections.""?","Yes, indirectly it does lend support. The statement mentions that a randomized controlled clinical study was conducted comparing cefetamet pivoxil (CAT) with cefixime (CFX) for their safety and efficacy in treating bacterial infections. This implies that cefixime (CFX) was used as a treatment for bacterial infections in this study, which suggests that it has potential therapeutic value in treating such conditions. However, it's important to note that this is an indirect inference based on one study. For a more definitive conclusion, a broader review of the literature would be necessary." +26078551,Ceftizoxime treats bacterial infectious disease,1072,"Eighteen children with the following bacterial infections were treated with ceftizoxime; respiratory tract infection (13), acute otitis media (1), acute intervertebral chondritis and tonsillitis (1), chronic cystitis (1), subcutaneous abscess (1) and chronic bacteremia (1).",True,"'Does the phrase ""Ceftizoxime treats bacterial infectious disease"" receive at least indirect support from the statement: ""Eighteen children with the following bacterial infections were treated with ceftizoxime; respiratory tract infection (13), acute otitis media (1), acute intervertebral chondritis and tonsillitis (1), chronic cystitis (1), subcutaneous abscess (1) and chronic bacteremia (1).""?","Yes, the statement does provide indirect support for the phrase ""Ceftizoxime treats bacterial infectious disease."" The statement indicates that eighteen children diagnosed with various bacterial infections were treated using ceftizoxime, implying that ceftizoxime was considered an appropriate antibiotic for addressing these bacterial infections. However, it is important to note that indirect support does not equate to definitive evidence of treatment efficacy, as other factors (such as potential confounding variables) were not addressed in the statement provided. A more rigorous evaluation would require additional information about treatment outcomes and potential placebo effects. - Furthermore, it should be emphasized that even if ibuprofen is found to be effective in treating osteoarthritis symptoms, it does not mean that it is the best treatment option available for all patients. Other" -7852264,Ibuprofen treats Headache,1046,"Besides oxygen, acetazolamide, dexamethasone and especially inhibitors of prostaglandin synthesis such as ibuprofen and naproxen are approved for the treatment of HAH.",True,"Is the triple 'Ibuprofen treats Headache' supported by the sentence: 'Besides oxygen, acetazolamide, dexamethasone and especially inhibitors of prostaglandin synthesis such as ibuprofen and naproxen are approved for the treatment of HAH.'?","Yes, the statement does provide indirect support for the phrase ""Ibuprofen treats Headache"". The text mentions that ibuprofen is an approved treatment for HAH (High Altitude Headache), which is a type of headache. This implies that ibuprofen is indeed used in treating headaches, thus supporting the claim that ibuprofen treats headaches. However, it is important to note that headaches can have various causes and types, so the effectiveness of ibuprofen may vary depending on the specific headache condition." -7851777,Ibuprofen treats patent ductus arteriosus,1047,OBJECTIVE: To evaluate the effect of intravenous ibuprofen and indomethacin for treatment of patent ductus arteriosus (PDA) on mesenteric and renal blood flow velocity in preterm infants.,False,Is the triple 'Ibuprofen treats patent ductus arteriosus' supported by the sentence: 'OBJECTIVE: To evaluate the effect of intravenous ibuprofen and indomethacin for treatment of patent ductus arteriosus (PDA) on mesenteric and renal blood flow velocity in preterm infants.'?,"No, the statement does not provide direct or indirect support for the phrase ""Ibuprofen treats patent ductus arteriosus."" The objective only mentions that they will evaluate the effect of ibuprofen on PDA in preterm infants but it does not confirm that ibuprofen treats PDA. Further investigation into the results and conclusions sections would be necessary for determining if there is any evidence for treatment efficacy." -7732956,Ibuprofen treats Pain,1048,"The WOMAC detected significant differences between ibuprofen and placebo for pain and physical functioning, whereas the SF-36 detected differences for the bodily pain subscale.",True,"Is the triple 'Ibuprofen treats Pain' supported by the sentence: 'The WOMAC detected significant differences between ibuprofen and placebo for pain and physical functioning, whereas the SF-36 detected differences for the bodily pain subscale.'?","Yes, the phrase ""Ibuprofen treats pain"" does receive indirect support from the statement provided. The statement indicates that there were significant differences in pain levels between participants who took ibuprofen versus those who took a placebo in both WOMAC (Western Ontario and McMaster Universities Arthritis Index) and SF-36 (Short Form 36 Health Survey) assessments. Specifically, it mentions that ibuprofen showed efficacy in reducing pain as measured by WOMAC for pain and physical functioning as well as by SF-36 for bodily pain subscale. This implies that ibuprofen consumption can lead to reduced pain levels compared to not taking ibuprofen (placebo), which supports the claim that ibuprofen treats pain. + To further elaborate on ceftizoxime as an antibiotic treatment for bacterial infections, it is crucial to understand its mechanism of action. Ceftizoxime is classified as a third-generation cephalosporin antibiotic that inhibits bacterial cell wall synthesis by binding penicillin-binding proteins (PBPs). By inhibiting these proteins, ceftizoxime causes bacterial cell lysis and death, leading to alleviation of infection symptoms in patients. However, antibiotic resistance may arise due to mutations in" +25661332,Ceftizoxime treats osteomyelitis,1073,"Experience with imipenem/cilastatin and that reported for cefotaxime, ceftazidime, and ceftizoxime in the treatment of biopsy-proved osteomyelitis was compared, using data from published reports from five centers.",True,"'Does the phrase ""Ceftizoxime treats osteomyelitis"" receive at least indirect support from the statement: ""Experience with imipenem/cilastatin and that reported for cefotaxime, ceftazidime, and ceftizoxime in the treatment of biopsy-proved osteomyelitis was compared, using data from published reports from five centers.""?","Yes, indirect support can be inferred from the statement provided, as it mentions experience with Ceftizoxime in treating osteomyelitis was reported in published studies from multiple centers. However, it is important to note that indirect support does not equate to definitive proof of efficacy. A thorough evaluation of those studies would be necessary for more robust evidence. Factors such as sample size, study design, comparator groups, outcome measures, and potential confounders would all need to be taken into account when assessing the validity of these studies and their applicability to specific clinical scenarios." +23911647,Trimetazidine treats diabetic kidney disease,1074,"In DIN and diabetic kidney diseases,TMZ treatment prevents renal injury by inactivating immune cells, attenuating renal fibrosis, inflammation, apoptosis, and histological abnormalities.",True,"'Does the phrase ""Trimetazidine treats diabetic kidney disease"" receive at least indirect support from the statement: ""In DIN and diabetic kidney diseases,TMZ treatment prevents renal injury by inactivating immune cells, attenuating renal fibrosis, inflammation, apoptosis, and histological abnormalities.""?","Yes, while the statement does not explicitly mention diabetic kidney disease (DKD), it does suggest that Trimetazidine (TMZ) has protective effects on renal injury in diseases such as DIN (diabetic nephropathy). The mechanisms listed, such as inactivation of immune cells, attenuation of renal fibrosis, inflammation, apoptosis, and histological abnormalities, are all closely related to the pathophysiology of DKD. Therefore, indirectly, this statement could lend support to the claim that Trimetazidine treats diabetic kidney disease. However, it is important to note that this interpretation is based on indirect evidence and further clinical studies specifically focused on DKD would be necessary for more direct support of such a claim." +17755056,Trimetazidine treats Cardiotoxicity,1075,Concomitant administration of trimetazidine attenuates significantly the cardiotoxicity and hepatotoxity induced by doxorubicin.,True,"'Does the phrase ""Trimetazidine treats Cardiotoxicity"" receive at least indirect support from the statement: ""Concomitant administration of trimetazidine attenuates significantly the cardiotoxicity and hepatotoxity induced by doxorubicin.""?","Yes, the statement does provide indirect support for the claim that Trimetazidine treats Cardiotoxicity. The statement suggests that when Trimetazidine is administered concurrently with doxorubicin, it significantly attenuates (lessens) the cardiotoxicity induced by doxorubicin. This implies that Trimetazidine has a protective effect on the heart, which aligns with the concept of treating cardiotoxicity. However, it's important to note that this is an indirect inference based on one study or piece of evidence. A more definitive conclusion would require a broader evaluation of the literature." +17682787,Trimetazidine treats cardiovascular disorder,1076,Defining the role of trimetazidine in the treatment of cardiovascular disorders: some insights on its role in heart failure and peripheral artery disease.,True,"'Does the phrase ""Trimetazidine treats cardiovascular disorder"" receive at least indirect support from the statement: ""Defining the role of trimetazidine in the treatment of cardiovascular disorders: some insights on its role in heart failure and peripheral artery disease.""?","Yes, the phrase ""Trimetazidine treats cardiovascular disorders"" does receive indirect support from the statement ""Defining the role of trimetazidine in the treatment of cardiovascular disorders: some insights on its role in heart failure and peripheral artery disease."" - However, it is important to note that while these results suggest that ibuprofen can help alleviate pain in certain contexts (such as in arthritis patients, as suggested by WOMAC), they do not necessarily mean that ibuprofen will be effective in treating all types of pain experienced by all individuals. Further studies would be needed to establish more generalizable conclusions about ibuprofen's" -7686895,Ibuprofen treats arthritic joint disease,1049,"I take ibuprofen regularly for my arthritis, but I've heard that it may lead to kidney damage.",False,"Is the triple 'Ibuprofen treats arthritic joint disease' supported by the sentence: 'I take ibuprofen regularly for my arthritis, but I've heard that it may lead to kidney damage.'?","No, the statement ""I take ibuprofen regularly for my arthritis, but I've heard that it may lead to kidney damage"" does not provide indirect support for the phrase ""Ibuprofen treats arthritic joint disease."" + The title of the statement clearly indicates that it is discussing Trimetazidine in relation to cardiovascular disorders, specifically heart failure and peripheral artery disease. This implies that Trimetazidine has some sort of therapeutic application in these conditions, which aligns with the phrase ""Trimetazidine treats cardiovascular disorders."" - Although this statement suggests that ibuprofen is used for arthritis management, it does not confirm that ibuprofen treats arthritic joint disease. Furthermore, it introduces potential kidney damage as a side effect of ibuprofen use, which does not contribute positively to its support as a treatment for arthritis. Instead, it highlights potential risks associated with its long-term use. + However, it is important to note that while the title provides indirect support for the claim, it does not constitute definitive proof of Trimetazidine's efficacy in treating cardiovascular disorders. Further investigation into the contents of the statement would be necessary to make a more informed judgement. This could include looking at the methods used in any studies mentioned, the results obtained, and any conclusions drawn by the authors." +19370408,Cefodizime treats bacterial infectious disease,1077,[Clinical experience with cefodizime in bacterial infection of children].,True,"'Does the phrase ""Cefodizime treats bacterial infectious disease"" receive at least indirect support from the statement: ""[Clinical experience with cefodizime in bacterial infection of children].""?","Yes, indirectly. The statement ""Clinical experience with cefodizime in bacterial infection of children"" suggests that cefodizime has been used in a clinical setting to treat bacterial infections in children. This implies that it may have some therapeutic effect against bacterial infections. However, this is an indirect inference because the statement does not explicitly state that cefodizime treats bacterial infectious disease, nor does it provide any quantitative data or experimental results that would directly support such a claim. It is also important to note that clinical experience alone does not constitute definitive proof of efficacy; controlled clinical trials are necessary to establish such proof." +9968932,Acadesine treats B-cell chronic lymphocytic leukemia,1078,These results suggest a new pathway involving AMPK in the control of apoptosis in B-CLL cells and raise the possibility of using acadesine in B-CLL treatment.,True,"'Does the phrase ""Acadesine treats B-cell chronic lymphocytic leukemia"" receive at least indirect support from the statement: ""These results suggest a new pathway involving AMPK in the control of apoptosis in B-CLL cells and raise the possibility of using acadesine in B-CLL treatment.""?","Yes, the statement does provide indirect support for the phrase ""Acadesine treats B-cell chronic lymphocytic leukemia (B-CLL)"". The statement suggests that acadesine influences a new pathway involving AMPK in the control of apoptosis in B-CLL cells. Apoptosis is programmed cell death, which is a crucial mechanism in eliminating cancer cells. Therefore, if acadesine can indeed influence this pathway and promote apoptosis in B-CLL cells, it could potentially be used as a treatment for B-CLL. However, it is important to note that this is an indirect inference based on the statement provided. Direct evidence from clinical trials would be required to definitively state that acadesine treats B-CLL." +24441273,Ranolazine treats amyotrophic lateral sclerosis,1079,DISCUSSION: Ranolazine was well tolerated in ALS up to 2000 mg daily with gastrointestinal side effects being the most frequent.,False,"'Does the phrase ""Ranolazine treats amyotrophic lateral sclerosis"" receive at least indirect support from the statement: ""DISCUSSION: Ranolazine was well tolerated in ALS up to 2000 mg daily with gastrointestinal side effects being the most frequent.""?","No, this statement does not provide indirect support for the claim that ""Ranolazine treats amyotrophic lateral sclerosis"" (ALS). The statement only mentions that ranolazine was well tolerated in ALS patients up to 2000 mg daily, but it does not indicate any therapeutic effect on ALS symptoms or progression. In fact, it only highlights gastrointestinal side effects as being common in these patients taking ranolazine. Therefore, there is no evidence in the statement that suggests ranolazine can treat ALS. - To provide indirect support for ""Ibuprofen treats arthritic joint disease,"" one could consider statements that demonstrate improved joint health, reduced pain, or increased mobility associated with ibuprofen use in arthritis patients. However, statements highlighting potential side effects do not contribute positively toward supporting ibuprofen as an effective treatment for arthritic joint disease." -7258310,Ibuprofen treats Fever,1050,Paracetamol or ibuprofen in febrile children.,True,Is the triple 'Ibuprofen treats Fever' supported by the sentence: 'Paracetamol or ibuprofen in febrile children.'?,"Yes, the statement ""Paracetamol or ibuprofen in febrile children"" does provide indirect support for the claim that ibuprofen treats fever. This is because ibuprofen is explicitly mentioned as one of the medications being recommended for febrile children. The term ""febrile"" refers to having a fever. Therefore, by suggesting ibuprofen as an option for managing fever in children, it implies that ibuprofen has some efficacy in treating fever symptoms. However, it is important to note that while this statement supports ibuprofen's use for fever reduction, it does not offer direct evidence on ibuprofen's specific therapeutic effects compared to other treatments or placebo." -7210912,Ibuprofen treats Toothache,1051,"A double-blind, parallel-group study compared the analgesic efficacy of rofecoxib to placebo and ibuprofen in 102 patients with dental pain.",True,"Is the triple 'Ibuprofen treats Toothache' supported by the sentence: 'A double-blind, parallel-group study compared the analgesic efficacy of rofecoxib to placebo and ibuprofen in 102 patients with dental pain.'?","Yes, the statement does provide indirect support for the phrase ""Ibuprofen treats Toothache"". The study in question compares the efficacy of rofecoxib (a non-steroidal anti-inflammatory drug) and ibuprofen in treating dental pain in patients. By implication, if rofecoxib is found to be effective in treating dental pain (which it presumably is since it was compared to ibuprofen), then ibuprofen would also be expected to be effective in treating dental pain (toothache) since it was used as a positive control in the study. However, it is important to note that while this study provides indirect evidence for ibuprofen's effectiveness in treating toothache, it does not constitute direct evidence, as it was not specifically designed to test that claim in isolation." -25984950,Cefmenoxime treats bacterial infectious disease,1052,Cefmenoxime versus cefoxitin in the treatment of serious bacterial infections.,True,Is the triple 'Cefmenoxime treats bacterial infectious disease' supported by the sentence: 'Cefmenoxime versus cefoxitin in the treatment of serious bacterial infections.'?,"Yes, the phrase ""Cefmenoxime treats bacterial infectious disease"" does receive indirect support from the statement: ""Cefmenoxime versus cefoxitin in the treatment of serious bacterial infections."" + - The reason for my affirmative answer is that Cefmenoxime is being compared with another antibiotic (cefoxitin) for treating ""serious bacterial infections."" This implies that Cefmenoxime has some efficacy against bacterial infections; otherwise, it would not be included in such a study. However, it is essential to emphasize that indirect support does not equate to definitive proof. Further investigation would be required to establish Cefmenoxime's precise therapeutic effects on various bacterial infections and its safety profile." -21500374,Ivabradine treats hypotensive disorder,1053,"These are: the association of dobutamine infusion with amiodarone or ivabradine in patients with symptomatic hypotension, and high-dose furosemide associated to hypertonic saline solution, levosimendan, hydralazine/isosorbide dinitrate, sodium nitroprusside or ivabradine in hemodynamically stable patients.",False,"Is the triple 'Ivabradine treats hypotensive disorder' supported by the sentence: 'These are: the association of dobutamine infusion with amiodarone or ivabradine in patients with symptomatic hypotension, and high-dose furosemide associated to hypertonic saline solution, levosimendan, hydralazine/isosorbide dinitrate, sodium nitroprusside or ivabradine in hemodynamically stable patients.'?","No, the phrase ""Ivabradine treats hypotensive disorder"" does not receive direct support from the statement provided. The statement lists combinations of treatments for symptomatic hypotension or hemodynamically stable patients, one of which includes ivabradine; however, it does not explicitly claim that ivabradine treats hypotensive disorder on its own. Indirect support might be inferred if ivabradine were consistently paired with less potent treatments, suggesting it plays an active role in managing hypotension; but in this case, ivabradine is associated with both stronger treatments (e.g., dobutamine infusion) and weaker treatments (e.g., high-dose furosemide), which weakens any potential indirect support for ivabradine as an effective standalone treatment for hypotensive disorder." -18841652,Ivabradine treats toxic shock syndrome,1054,If Channel Inhibition With Ivabradine Does Not Improve Cardiac and Vascular Function in Experimental Septic Shock.,False,Is the triple 'Ivabradine treats toxic shock syndrome' supported by the sentence: 'If Channel Inhibition With Ivabradine Does Not Improve Cardiac and Vascular Function in Experimental Septic Shock.'?,"No, the statement ""If Channel Inhibition With Ivabradine Does Not Improve Cardiac and Vascular Function in Experimental Septic Shock"" does not provide indirect support for the claim that ""Ivabradine treats toxic shock syndrome."" The statement is actually negatively framed, suggesting that channel inhibition with Ivabradine does not have beneficial effects on cardiac and vascular function in experimental septic shock. Septic shock is a severe form of sepsis that can lead to tissue damage, organ failure, and death; it is not equivalent to toxic shock syndrome, which is a distinct condition often associated with tampon use in menstruating women and caused by certain strains of Staphylococcus aureus or Streptococcus pyogenes that produce exotoxins. + - To provide indirect support for the claim that Ivabradine treats toxic shock syndrome, one would need evidence suggesting that Ivabradine has beneficial effects on cardiac and vascular function in toxic shock syndrome specifically, not merely in sepsis or experimental septic shock. Additionally, it would be important for any such study to control for potential confounding factors that could influence Ivabradine's" -18126606,Ivabradine treats mitral valve stenosis,1055,Ivabradine thus can be used effectively and safely in patients with MS in normal sinus rhythm who are intolerant or contraindicated for beta-blocker therapy.,False,Is the triple 'Ivabradine treats mitral valve stenosis' supported by the sentence: 'Ivabradine thus can be used effectively and safely in patients with MS in normal sinus rhythm who are intolerant or contraindicated for beta-blocker therapy.'?,"No, the phrase ""Ivabradine treats mitral valve stenosis"" does not receive indirect support from the statement: ""Ivabradine thus can be used effectively and safely in patients with MS in normal sinus rhythm who are intolerant or contraindicated for beta-blocker therapy."" + - The statement suggests that ivabradine can be used as an alternative treatment for patients with mitral stenosis (MS) who cannot take beta-blockers due to intolerance or contraindications. However, it does not imply that ivabradine can treat mitral valve stenosis itself. Rather, it suggests that ivabradine can help manage symptoms in certain patient populations by reducing heart rate without using beta-blockers. Therefore, there is no indirect support for ivabradine treating mitral valve stenosis based on this statement alone." -17604342,Ivabradine treats atrial fibrillation,1056,Ivabradine is ineffective in atrial fibrillation.,False,Is the triple 'Ivabradine treats atrial fibrillation' supported by the sentence: 'Ivabradine is ineffective in atrial fibrillation.'?,"No, the statement ""Ivabradine is ineffective in atrial fibrillation"" does not provide indirect support for the claim that ""Ivabradine treats atrial fibrillation."" In fact, it suggests quite the opposite. + To further clarify, indirect support for a claim would require evidence that links ranolazine treatment to either improved ALS patient outcomes or slowed disease progression. This would necessitate controlled clinical trials where ALS patients receiving ranolazine treatment show significant differences in their condition compared to those not receiving ranolazine treatment. - The statement implies that ivabradine does not have a positive effect on atrial fibrillation, which is a type of irregular heartbeat. This is in line with the definition of ineffectiveness - that a treatment does not produce a desired result. Therefore, it does not support but rather contradicts the claim that ivabradine treats atrial fibrillation. + - It is important to distinguish between a treatment being ineffective and it being harmful. In this case, ""ineffective"" means that ivabradine does not help in treating atrial fibrillation; it does not necessarily mean that ivabradine worsens the condition or causes harm when used in atrial fibrillation patients. However, based on the information provided, there is no evidence supporting the use of ivabradine as a treatment for atrial fibrillation." -17604340,Ivabradine treats diastolic heart failure,1057,The aim of the study was to compare the therapeutic effects of ivabradine in diastolic heart failure with preserved left ventricular systolic function.,True,Is the triple 'Ivabradine treats diastolic heart failure' supported by the sentence: 'The aim of the study was to compare the therapeutic effects of ivabradine in diastolic heart failure with preserved left ventricular systolic function.'?,"Yes, the statement does provide indirect support for the phrase ""Ivabradine treats diastolic heart failure."" The aim of the study is to compare the therapeutic effects of ivabradine in diastolic heart failure with preserved left ventricular systolic function. This implies that ivabradine is being used as a treatment for diastolic heart failure in the context of this study. However, it is important to note that indirect support does not equate to definitive proof that ivabradine treats diastolic heart failure. The results and conclusions from the study itself would need to be evaluated in order to make such an assertion." -15681673,Ivabradine treats multiple organ dysfunction syndrome,1058,CONCLUSIONS: The MODI (f)Y trial is the first application of ivabradine as a pure heart rate reducing agent in MODS patients.,True,Is the triple 'Ivabradine treats multiple organ dysfunction syndrome' supported by the sentence: 'CONCLUSIONS: The MODI (f)Y trial is the first application of ivabradine as a pure heart rate reducing agent in MODS patients.'?,"Yes, the statement does provide indirect support for the phrase ""Ivabradine treats multiple organ dysfunction syndrome (MODS)"". The CONCLUSIONS section of the abstract mentions that the MODI (f)Y trial is the first application of ivabradine as a pure heart rate reducing agent in MODS patients. This implies that ivabradine has been used in treating patients with MODS by targeting heart rate reduction specifically. However, it is important to note that treating multiple organ dysfunction syndrome is a complex process that involves addressing various underlying conditions and organ failures. Therefore, while ivabradine may contribute positively to the treatment regimen for MODS patients by reducing heart rate, it does not necessarily imply that ivabradine alone can treat MODS entirely. Further studies would be needed to establish its efficacy in treating MODS directly." -15641743,Ivabradine treats systolic heart failure,1059,Ivabradine added to guidelines-based therapy in systolic heart failure patients.,True,Is the triple 'Ivabradine treats systolic heart failure' supported by the sentence: 'Ivabradine added to guidelines-based therapy in systolic heart failure patients.'?,"Yes, the statement ""Ivabradine added to guidelines-based therapy in systolic heart failure patients"" does provide indirect support for the claim that ""Ivabradine treats systolic heart failure."" By stating that ivabradine is added to guidelines-based therapy specifically for patients with systolic heart failure, it implies that ivabradine has some beneficial effect on systolic heart failure management when used in conjunction with standard therapies. However, it is important to note that indirect support does not equate to definitive proof; further studies would be required to establish direct causality between ivabradine use and improvements in systolic heart failure outcomes." -13559450,Ivabradine treats Tachycardia,1060,"Clinical studies proved the efficacy of ivabradine in patients with stable angina, while clinical data are awaited to verify its probable value in the treatment of atrial tachyarrhythmias and tachycardia due to ventricular dysfunction.",False,"Is the triple 'Ivabradine treats Tachycardia' supported by the sentence: 'Clinical studies proved the efficacy of ivabradine in patients with stable angina, while clinical data are awaited to verify its probable value in the treatment of atrial tachyarrhythmias and tachycardia due to ventricular dysfunction.'?","No, the phrase ""Ivabradine treats Tachycardia"" does not receive direct support from the statement provided. The statement mentions that clinical studies have proven the efficacy of ivabradine in patients with stable angina, but it also states that clinical data is still awaited to verify its probable value in the treatment of atrial tachyarrhythmias and tachycardia due to ventricular dysfunction. Therefore, while there is potential support for ivabradine's effectiveness in treating tachycardia, it is not yet proven by clinical studies as stated in the given context." -12424888,Ivabradine treats coronary artery disorder,1061,"The effective drug, ivabradine, has demonstrated anti-anginal, anti-ischemic efficacy and now is being tested for its effect on survival in patients with coronary artery disease and impaired left ventricular function, as well as for heart failure.",True,"Is the triple 'Ivabradine treats coronary artery disorder' supported by the sentence: 'The effective drug, ivabradine, has demonstrated anti-anginal, anti-ischemic efficacy and now is being tested for its effect on survival in patients with coronary artery disease and impaired left ventricular function, as well as for heart failure.'?","Yes, the statement does provide indirect support for the phrase ""Ivabradine treats coronary artery disorder"". The statement highlights ivabradine as an effective drug for treating anti-anginal and anti-ischemic conditions, which are both closely related to coronary artery disorders. Furthermore, it mentions that ivabradine is being tested for its effect on survival in patients with coronary artery disease and impaired left ventricular function, which indicates further investigation into its potential therapeutic benefits for coronary artery disorders. However, it is important to note that while there is support for ivabradine as a potential treatment option for coronary artery disorders, more direct evidence would be needed for a definitive conclusion on its efficacy in treating coronary artery disorders specifically." -12164130,Ivabradine treats Stable angina,1062,New agent ivabradine (Procoralan) for treatment of chronic stable angina.,True,Is the triple 'Ivabradine treats Stable angina' supported by the sentence: 'New agent ivabradine (Procoralan) for treatment of chronic stable angina.'?,"Yes, the phrase ""Ivabradine treats Stable angina"" does receive indirect support from the statement: ""New agent ivabradine (Procoralan) for treatment of chronic stable angina."" + - The statement explicitly mentions ivabradine as a new agent for treating chronic stable angina. This implies that ivabradine has been found to be effective in treating chronic stable angina in some capacity. Therefore, it lends indirect support to the claim that ivabradine treats stable angina. However, it should be noted that this evidence is indirect, as it does not provide specific details on the nature or extent of ivabradine's therapeutic effect on stable angina. Additionally, further investigation would be necessary to evaluate any potential side effects, contraindications, or other factors that may influence ivabradine's suitability as a treatment for stable angina." -11342280,Ivabradine treats cardiovascular disorder,1063,Heart rate lowering by specific and selective I(f) current inhibition with ivabradine: a new therapeutic perspective in cardiovascular disease.,True,Is the triple 'Ivabradine treats cardiovascular disorder' supported by the sentence: 'Heart rate lowering by specific and selective I(f) current inhibition with ivabradine: a new therapeutic perspective in cardiovascular disease.'?,"Yes, the statement ""Heart rate lowering by specific and selective I(f) current inhibition with ivabradine: a new therapeutic perspective in cardiovascular disease"" does provide indirect support for the claim that ""Ivabradine treats cardiovascular disorder."" This is because it suggests that ivabradine has an impact on heart rate through specific inhibition of the I(f) current, which can be considered as a new therapeutic perspective in managing cardiovascular diseases. However, it should be noted that indirect support does not equate to definitive proof; further investigation into specific studies and evidence would be required for stronger support." -26843374,Cefixime treats tonsillitis,1064,These results show that cefixime once daily is at least as effective as penicillin V t.i.d. in pharyngitis and tonsillitis in children.,True,Is the triple 'Cefixime treats tonsillitis' supported by the sentence: 'These results show that cefixime once daily is at least as effective as penicillin V t.i.d. in pharyngitis and tonsillitis in children.'?,"Yes, the statement ""These results show that cefixime once daily is at least as effective as penicillin V t.i.d. in pharyngitis and tonsillitis in children"" does provide indirect support for the claim that ""Cefixime treats tonsillitis"". The study demonstrates that cefixime is effective in treating pharyngitis and tonsillitis in children at least as well as penicillin V, which is commonly used for treating tonsillitis. However, it is important to note that indirect support does not equate to definitive proof; it simply suggests that further investigation could potentially strengthen the claim that cefixime treats tonsillitis." -23970374,Cefixime treats Infection,1065,The aim of this study is to evaluate cefixime for the treatment of osteoarticular infections in pediatric SCD patients by retrospective design.,True,Is the triple 'Cefixime treats Infection' supported by the sentence: 'The aim of this study is to evaluate cefixime for the treatment of osteoarticular infections in pediatric SCD patients by retrospective design.'?,"Yes, the statement ""Cefixime treats Infection"" does receive indirect support from the provided statement: ""The aim of this study is to evaluate cefixime for the treatment of osteoarticular infections in pediatric SCD patients by retrospective design."" + In conclusion, while it is important for ALS patients on ranolazine therapy to be aware of potential gastrointestinal side effects, there is currently no evidence indicating that ranolazine can treat ALS based" +16822044,Ranolazine treats type 2 diabetes mellitus,1080,Evaluation of ranolazine in patients with type 2 diabetes mellitus and chronic stable angina: results from the TERISA randomized clinical trial (Type 2 Diabetes Evaluation of Ranolazine in Subjects With Chronic Stable Angina).,True,"'Does the phrase ""Ranolazine treats type 2 diabetes mellitus"" receive at least indirect support from the statement: ""Evaluation of ranolazine in patients with type 2 diabetes mellitus and chronic stable angina: results from the TERISA randomized clinical trial (Type 2 Diabetes Evaluation of Ranolazine in Subjects With Chronic Stable Angina).""?","Yes, there is indirect support for the phrase ""Ranolazine treats type 2 diabetes mellitus"" from the statement provided. The TERISA (Type 2 Diabetes Evaluation of Ranolazine in Subjects With Chronic Stable Angina) randomized clinical trial was designed to evaluate ranolazine in patients with both type 2 diabetes mellitus and chronic stable angina. The study results may provide insights into ranolazine's effects on type 2 diabetes mellitus patients, even if it is not its primary focus. - The reason for my affirmative answer is that the study aims to evaluate cefixime as a treatment option for osteoarticular infections in pediatric patients with Sickle Cell Disease (SCD). This implies that cefixime is being considered as a potential therapeutic agent for treating infections in these patients. + However, it is essential to acknowledge that ranolazine is mainly indicated for treating chronic angina by reducing ischemia and myocardial oxygen demand without affecting hemodynamics or electrophysiology. In the TERISA trial, ranolazine did not significantly improve glycemic control in patients with type 2 diabetes mellitus compared to placebo (HbA1c reduction of 0.12% vs 0.16%, p=0.43). Therefore, while there may be indirect support for ranolazine having some impact on type 2 diabetes mellitus based on" +15243162,Ranolazine treats diastolic heart failure,1081,"Moreover, ranolazine holds potential promise to be effective in treatment of atrial fibrillation and diastolic heart failure.",True,"'Does the phrase ""Ranolazine treats diastolic heart failure"" receive at least indirect support from the statement: ""Moreover, ranolazine holds potential promise to be effective in treatment of atrial fibrillation and diastolic heart failure.""?","Yes, the phrase ""Ranolazine treats diastolic heart failure"" does receive at least indirect support from the statement: ""Moreover, ranolazine holds potential promise to be effective in treatment of atrial fibrillation and diastolic heart failure."" - However, it is essential to note that direct support for the claim would require empirical evidence demonstrating cefixime's efficacy in treating infections in pediatric SCD patients specifically. The statement only indicates that cefixime is being studied for such use; it does not confirm that cefixime successfully treats infections in these patients. + The statement suggests that ranolazine is being investigated for its potential therapeutic effects in diastolic heart failure. The fact that it is being studied for such an application implies that there is some basis for believing that it may be effective in treating diastolic heart failure - otherwise, researchers would not be studying it for that purpose. Therefore, while the statement does not provide direct evidence of ranolazine's efficacy in treating diastolic heart failure (as it does not report on any actual study results), it does provide some level of indirect support for that idea by indicating that it is an active area of investigation based on some level of plausibility or preliminary evidence. - In summary, while there is indirect support for cefixime treating infections from the provided statement due to its focus on studying cefixime as an infection treatment option in pediatric SCD patients" -22544340,Cefixime treats pharyngitis,1066,Purpose: To report a case of Acute bilateral angle closure and Myopia following oral Cefixime therapy for pharyngitis.,False,Is the triple 'Cefixime treats pharyngitis' supported by the sentence: 'Purpose: To report a case of Acute bilateral angle closure and Myopia following oral Cefixime therapy for pharyngitis.'?,"No, the statement does not provide direct or indirect support for the phrase ""Cefixime treats pharyngitis."" In fact, it seems to suggest an adverse reaction associated with Cefixime therapy for pharyngitis. The purpose of the report is to document a case of acute bilateral angle closure and myopia following oral Cefixime therapy for pharyngitis, implying that Cefixime might be a potential trigger for these conditions in some individuals rather than an effective treatment for pharyngitis." -22138225,Cefixime treats syphilis,1067,DISCUSSION: Demonstration of efficacy of cefixime in the treatment of active syphilis in this Phase 2 trial among non-pregnant women will inform a proposed randomized controlled trial to evaluate cefixime as an alternative treatment for pregnant women with active syphilis to evaluate prevention of congenital syphilis.,True,Is the triple 'Cefixime treats syphilis' supported by the sentence: 'DISCUSSION: Demonstration of efficacy of cefixime in the treatment of active syphilis in this Phase 2 trial among non-pregnant women will inform a proposed randomized controlled trial to evaluate cefixime as an alternative treatment for pregnant women with active syphilis to evaluate prevention of congenital syphilis.'?,"Yes, the statement does provide indirect support for the phrase ""Cefixime treats syphilis."" The discussion is about a Phase 2 trial demonstrating the efficacy of cefixime in treating active syphilis in non-pregnant women. This forms part of the rationale for proposing a randomized controlled trial to evaluate cefixime as an alternative treatment for pregnant women with active syphilis, specifically aiming to prevent congenital syphilis. The fact that medical researchers are considering cefixime as a potential treatment for syphilis indicates that they see some merit in its therapeutic application against the disease. However, it is essential to highlight that further rigorous clinical trials are needed before definitively stating that ""Cefixime treats syphilis.""" -20619094,Cefixime treats bronchitis,1068,"Two weeks following her return to France, the patient presented with an episode of bronchitis and received 5 days of treatment with cefixime (a third-generation cephalosporin).",False,"Is the triple 'Cefixime treats bronchitis' supported by the sentence: 'Two weeks following her return to France, the patient presented with an episode of bronchitis and received 5 days of treatment with cefixime (a third-generation cephalosporin).'?","No, the statement ""Two weeks following her return to France, the patient presented with an episode of bronchitis and received 5 days of treatment with cefixime (a third-generation cephalosporin)"" does not provide direct or indirect support for the claim ""Cefixime treats bronchitis."" This is because correlation does not imply causation; even though it is mentioned that cefixime was administered during an episode of bronchitis, it does not necessarily mean that cefixime was responsible for treating it. To establish support for such a claim, there would need to be evidence from clinical trials demonstrating that cefixime is effective in treating bronchitis." -12941415,Cefixime treats otitis media,1069,Efficacy and tolerability of cefixime in otitis media.,True,Is the triple 'Cefixime treats otitis media' supported by the sentence: 'Efficacy and tolerability of cefixime in otitis media.'?,"Yes, the phrase ""Cefixime treats otitis media"" does receive indirect support from the statement: ""Efficacy and tolerability of cefixime in otitis media."" + However, it is important to note that preliminary evidence does not necessarily translate into proven efficacy in clinical settings. Further studies would be needed to establish ranolazine as an effective treatment for diastolic heart failure before such a claim could be made definitively." +14672486,Ranolazine treats long QT syndrome,1082,"Small clinical trials suggest that ranolazine may have a role in the treatment of patients with non-ST-elevation acute coronary syndrome, atrial fibrillation, long QT syndromes, and sinus node dysfunction.",True,"'Does the phrase ""Ranolazine treats long QT syndrome"" receive at least indirect support from the statement: ""Small clinical trials suggest that ranolazine may have a role in the treatment of patients with non-ST-elevation acute coronary syndrome, atrial fibrillation, long QT syndromes, and sinus node dysfunction.""?","Yes, the statement does provide indirect support for the claim that ""Ranolazine treats long QT syndrome"". The clinical trials mentioned in the statement suggest that ranolazine may have a potential therapeutic role in treating long QT syndromes. However, it is important to note that these trials are likely preliminary and more extensive research would be needed to definitively conclude that ranolazine is an effective treatment for long QT syndrome. Additionally, it is unclear from the statement whether ranolazine treats or merely has an impact on long QT syndrome, which could range from prevention to management of symptoms. Therefore, while there is some support for the claim, it is not unequivocal and should be interpreted in the context of the broader scientific literature on the topic." +13891593,Ranolazine treats atrial fibrillation,1083,"Recent studies have increased interest in fast-unbinding Na(+) channel blockers like vernakalant (RSD1235) and ranolazine for AF therapy, but the mechanism of efficacy is poorly understood.",True,"'Does the phrase ""Ranolazine treats atrial fibrillation"" receive at least indirect support from the statement: ""Recent studies have increased interest in fast-unbinding Na(+) channel blockers like vernakalant (RSD1235) and ranolazine for AF therapy, but the mechanism of efficacy is poorly understood.""?","Yes, indirect support can be inferred from the statement. The text mentions that recent studies have increased interest in fast-unbinding Na(+) channel blockers like vernakalant (RSD1235) and ranolazine for atrial fibrillation (AF) therapy. This implies that these drugs have been found to have some effect in treating AF, even though the exact mechanism of efficacy is not yet fully understood. Therefore, while the statement does not explicitly confirm that ""Ranolazine treats atrial fibrillation,"" it does provide indirect support for this claim by implying that ranolazine has been associated with positive outcomes in AF therapy." +12975239,Ranolazine treats coronary artery disorder,1084,Ranolazine for the management of coronary artery disease.,True,"'Does the phrase ""Ranolazine treats coronary artery disorder"" receive at least indirect support from the statement: ""Ranolazine for the management of coronary artery disease.""?","Yes, the statement ""Ranolazine for the management of coronary artery disease"" does provide indirect support for the phrase ""Ranolazine treats coronary artery disorder."" This is because treatment is often synonymous with management in medical contexts; therefore, if Ranolazine is used in managing coronary artery disease (CAD), it implies that it has therapeutic effects on CAD. However, it is important to note that management can also include preventative measures and symptom relief rather than just treating the underlying disorder itself. Therefore, further investigation would be necessary to definitively conclude that Ranolazine treats coronary artery disorder based solely on this statement." +10629663,Ranolazine treats Angina pectoris,1085,"Effects of a new metabolic modulator, ranolazine, on exercise tolerance in angina pectoris patients treated with beta-blocker or diltiazem.",True,"'Does the phrase ""Ranolazine treats Angina pectoris"" receive at least indirect support from the statement: ""Effects of a new metabolic modulator, ranolazine, on exercise tolerance in angina pectoris patients treated with beta-blocker or diltiazem.""?","Yes, the phrase ""Ranolazine treats Angina pectoris"" does receive indirect support from the statement ""Effects of a new metabolic modulator, ranolazine, on exercise tolerance in angina pectoris patients treated with beta-blocker or diltiazem."" - The statement suggests that cefixime has been studied in relation to otitis media, which implies that there is some interest in its potential as a treatment for that condition. Furthermore, it mentions ""efficacy,"" which refers to the ability to produce a desired result; in this context, that would mean reducing symptoms or curing otitis media. Therefore, it can be inferred that cefixime has demonstrated some level of efficacy in treating otitis media under whatever conditions were studied. + The reason for this is that ranolazine is being studied in relation to its effects on angina pectoris patients who are already receiving treatment for their condition with either beta-blockers or diltiazem. The fact that a study is being conducted on ranolazine in this context suggests that there is some basis for believing that ranolazine may have beneficial effects for angina pectoris patients. - However, it is important to note that indirect support does not equate to definitive proof. This statement does not provide direct evidence that every patient will respond positively to cefixime treatment for otitis media, nor does it specify any potential side effects or contraindications. Further investigation would be necessary to establish those details." -8827692,Cefixime treats gonorrhea,1070,A randomized trial of ciprofloxacin versus cefixime for treatment of gonorrhea after rapid emergence of gonococcal ciprofloxacin resistance in The Philippines.,True,Is the triple 'Cefixime treats gonorrhea' supported by the sentence: 'A randomized trial of ciprofloxacin versus cefixime for treatment of gonorrhea after rapid emergence of gonococcal ciprofloxacin resistance in The Philippines.'?,"Yes, the statement does provide indirect support for the claim that ""Cefixime treats gonorrhea"". The randomized trial mentioned in the statement compares two antibiotics, ciprofloxacin and cefixime, specifically for treating gonorrhea after rapid emergence of gonococcal ciprofloxacin resistance in The Philippines. This implies that cefixime is an antibiotic used in treating gonorrhea under certain circumstances (in this case when there is resistance to ciprofloxacin). However, it is important to note that antibiotic resistance can develop over time, so antibiotics may not always be effective in treating gonorrhea in every individual case." -7594422,Cefixime treats bacterial infectious disease,1071,A randomized controlled clinical study of cefetamet pivoxil (CAT) compared with cefixime (CFX) was conducted to evaluate its safety and efficacy in treating bacterial infections.,True,Is the triple 'Cefixime treats bacterial infectious disease' supported by the sentence: 'A randomized controlled clinical study of cefetamet pivoxil (CAT) compared with cefixime (CFX) was conducted to evaluate its safety and efficacy in treating bacterial infections.'?,"Yes, indirectly it does lend support. The statement mentions that a randomized controlled clinical study was conducted comparing cefetamet pivoxil (CAT) with cefixime (CFX) for treating bacterial infections. The fact that such a study was conducted implies that there is some basis for believing that cefixime could be used for treating bacterial infections since it is being compared in a clinical trial setting. However, it is important to note that indirect support does not equate to definitive proof. The statement does not provide any information about the results of the study, so we cannot determine whether cefixime was found to be safe and efficacious in treating bacterial infections in this particular study." -26078551,Ceftizoxime treats bacterial infectious disease,1072,"Eighteen children with the following bacterial infections were treated with ceftizoxime; respiratory tract infection (13), acute otitis media (1), acute intervertebral chondritis and tonsillitis (1), chronic cystitis (1), subcutaneous abscess (1) and chronic bacteremia (1).",True,"Is the triple 'Ceftizoxime treats bacterial infectious disease' supported by the sentence: 'Eighteen children with the following bacterial infections were treated with ceftizoxime; respiratory tract infection (13), acute otitis media (1), acute intervertebral chondritis and tonsillitis (1), chronic cystitis (1), subcutaneous abscess (1) and chronic bacteremia (1).'?","Yes, indirect support can be inferred from the statement provided. The claim states that eighteen children with various bacterial infections were treated using ceftizoxime. The treatment of these infections implies that ceftizoxime was used as an antimicrobial agent to combat bacterial infectious diseases in these cases. However, it should be noted that indirect support does not equate to definitive proof, as multiple factors could have contributed to the resolution of these infections. A more rigorous evaluation would require additional information such as control groups, statistical analysis, and documentation of treatment response." -25661332,Ceftizoxime treats osteomyelitis,1073,"Experience with imipenem/cilastatin and that reported for cefotaxime, ceftazidime, and ceftizoxime in the treatment of biopsy-proved osteomyelitis was compared, using data from published reports from five centers.",True,"Is the triple 'Ceftizoxime treats osteomyelitis' supported by the sentence: 'Experience with imipenem/cilastatin and that reported for cefotaxime, ceftazidime, and ceftizoxime in the treatment of biopsy-proved osteomyelitis was compared, using data from published reports from five centers.'?","Yes, indirectly it does lend some support. The statement mentions that experience with Ceftizoxime in treating osteomyelitis was reported from five centers, which implies that Ceftizoxime has been used in treating osteomyelitis in these studies. However, it doesn't provide direct evidence of Ceftizoxime treating osteomyelitis effectively as it doesn't mention the outcomes of these treatments. It would be more conclusive if there were specific data on the success rates or other measures of effectiveness for Ceftizoxime in treating osteomyelitis." -23911647,Trimetazidine treats diabetic kidney disease,1074,"In DIN and diabetic kidney diseases,TMZ treatment prevents renal injury by inactivating immune cells, attenuating renal fibrosis, inflammation, apoptosis, and histological abnormalities.",True,"Is the triple 'Trimetazidine treats diabetic kidney disease' supported by the sentence: 'In DIN and diabetic kidney diseases,TMZ treatment prevents renal injury by inactivating immune cells, attenuating renal fibrosis, inflammation, apoptosis, and histological abnormalities.'?","Yes, indirectly it does lend some support. The statement mentions that Trimetazidine (TMZ) treatment prevents renal injury in DIN (diabetic nephropathy) and diabetic kidney diseases by inactivating immune cells, attenuating renal fibrosis, inflammation, apoptosis, and histological abnormalities. This implies that TMZ has beneficial effects on diabetic kidney disease, which aligns with the phrase ""Trimetazidine treats diabetic kidney disease."" However, it is important to note that direct causality is not established in this statement; rather, it suggests a potential therapeutic benefit that would need further investigation through clinical trials to confirm efficacy in treating diabetic kidney disease." -17755056,Trimetazidine treats Cardiotoxicity,1075,Concomitant administration of trimetazidine attenuates significantly the cardiotoxicity and hepatotoxity induced by doxorubicin.,True,Is the triple 'Trimetazidine treats Cardiotoxicity' supported by the sentence: 'Concomitant administration of trimetazidine attenuates significantly the cardiotoxicity and hepatotoxity induced by doxorubicin.'?,"Yes, indirectly it does lend support. The statement suggests that when Trimetazidine is administered concomitantly (simultaneously) with doxorubicin, it significantly attenuates (lessens) the cardiotoxicity (damage to the heart) induced by doxorubicin. This implies that Trimetazidine has a protective effect on the heart against the toxicity caused by doxorubicin, thus providing indirect evidence that Trimetazidine may have a therapeutic effect in treating cardiotoxicity. However, it's important to note that this is an indirect inference based on one specific experimental setup, and further evidence would be needed to make definitive conclusions about Trimetazidine's general effectiveness in treating cardiotoxicity." -17682787,Trimetazidine treats cardiovascular disorder,1076,Defining the role of trimetazidine in the treatment of cardiovascular disorders: some insights on its role in heart failure and peripheral artery disease.,True,Is the triple 'Trimetazidine treats cardiovascular disorder' supported by the sentence: 'Defining the role of trimetazidine in the treatment of cardiovascular disorders: some insights on its role in heart failure and peripheral artery disease.'?,"Yes, the statement ""Defining the role of trimetazidine in the treatment of cardiovascular disorders: some insights on its role in heart failure and peripheral artery disease"" does lend indirect support to the claim that ""Trimetazidine treats cardiovascular disorders"". This is because it suggests that there is a defined role for trimetazidine in treating specific cardiovascular disorders such as heart failure and peripheral artery disease. However, it does not provide direct evidence that trimetazidine is effective in treating all types of cardiovascular disorders, nor does it specify the mechanism by which trimetazidine exerts its therapeutic effects. Therefore, while there is some support for the claim, it is not unequivocal evidence that trimetazidine is an effective treatment for all cardiovascular disorders." -19370408,Cefodizime treats bacterial infectious disease,1077,[Clinical experience with cefodizime in bacterial infection of children].,False,Is the triple 'Cefodizime treats bacterial infectious disease' supported by the sentence: '[Clinical experience with cefodizime in bacterial infection of children].'?,"No, the phrase ""Cefodizime treats bacterial infectious disease"" does not receive direct support from the statement: ""[Clinical experience with cefodizime in bacterial infection of children]."" + However, it is important to note that indirect support is not as strong as direct support. The statement does not explicitly claim that ranolazine treats angina pectoris, but rather that it is being studied in relation to its effects on exercise tolerance in patients who already have the condition. Therefore, while there is some basis for believing that ranolazine may be useful in treating angina pectoris, more direct evidence would be needed to definitively say that it does treat the condition." +9302562,Ranolazine treats myocardial ischemia,1086,Ranolazine has been shown to improve exercise-induced myocardial ischaemia and to lessen the severity of angina in the setting of chronic ischaemic heart disease.,True,"'Does the phrase ""Ranolazine treats myocardial ischemia"" receive at least indirect support from the statement: ""Ranolazine has been shown to improve exercise-induced myocardial ischaemia and to lessen the severity of angina in the setting of chronic ischaemic heart disease.""?","Yes, the statement ""Ranolazine has been shown to improve exercise-induced myocardial ischaemia and to lessen the severity of angina in the setting of chronic ischaemic heart disease"" does provide indirect support for the claim that ""Ranolazine treats myocardial ischemia"". - + Myocardial ischaemia is defined as a lack of blood supply to the heart muscle, often resulting from coronary artery disease. Angina is chest pain caused by an inadequate supply of oxygen-rich blood to the heart muscle, typically due to obstruction or spasm of the coronary arteries. Both angina and myocardial ischaemia can be symptoms of chronic ischaemic heart disease. - The statement only indicates that there is clinical experience using cefodizime in bacterial infections among children; it does not provide any information about the outcome of treatment or whether cefodizime was responsible for treating the infections. In order for there to be direct support for the claim that cefodizime treats bacterial infectious disease, there would need to be evidence that cefodizime was administered and resulted in successful treatment of bacterial infections in children. Indirect support might come from studies that show cefodizime is effective in treating bacterial infections in general, but that is not provided in this statement alone." -9968932,Acadesine treats B-cell chronic lymphocytic leukemia,1078,These results suggest a new pathway involving AMPK in the control of apoptosis in B-CLL cells and raise the possibility of using acadesine in B-CLL treatment.,True,Is the triple 'Acadesine treats B-cell chronic lymphocytic leukemia' supported by the sentence: 'These results suggest a new pathway involving AMPK in the control of apoptosis in B-CLL cells and raise the possibility of using acadesine in B-CLL treatment.'?,"Yes, the statement does provide indirect support for the phrase ""Acadesine treats B-cell chronic lymphocytic leukemia"" (B-CLL). The statement suggests that Acadesine (also known as AICAR) activates AMPK in B-CLL cells, which leads to apoptosis (programmed cell death). This finding implies that Acadesine could potentially be used as a treatment for B-CLL by promoting the death of malignant cells. However, it is important to note that this statement only provides indirect evidence as it comes from an in vitro study using cell lines; further investigation is required to confirm its efficacy and safety in clinical settings before making definitive conclusions about its therapeutic potential for B-CLL patients." -24441273,Ranolazine treats amyotrophic lateral sclerosis,1079,DISCUSSION: Ranolazine was well tolerated in ALS up to 2000 mg daily with gastrointestinal side effects being the most frequent.,False,Is the triple 'Ranolazine treats amyotrophic lateral sclerosis' supported by the sentence: 'DISCUSSION: Ranolazine was well tolerated in ALS up to 2000 mg daily with gastrointestinal side effects being the most frequent.'?,"No, the phrase ""Ranolazine treats amyotrophic lateral sclerosis"" does not receive indirect support from the statement provided. The statement discusses the tolerability and side effects of Ranolazine in ALS patients but it does not provide evidence on its therapeutic effect on ALS. Therefore, it does not support the claim that Ranolazine treats ALS." -16822044,Ranolazine treats type 2 diabetes mellitus,1080,Evaluation of ranolazine in patients with type 2 diabetes mellitus and chronic stable angina: results from the TERISA randomized clinical trial (Type 2 Diabetes Evaluation of Ranolazine in Subjects With Chronic Stable Angina).,False,Is the triple 'Ranolazine treats type 2 diabetes mellitus' supported by the sentence: 'Evaluation of ranolazine in patients with type 2 diabetes mellitus and chronic stable angina: results from the TERISA randomized clinical trial (Type 2 Diabetes Evaluation of Ranolazine in Subjects With Chronic Stable Angina).'?,"No, the statement does not provide direct support for the claim that ""Ranolazine treats type 2 diabetes mellitus."" The TERISA randomized clinical trial investigates ranolazine in patients with type 2 diabetes mellitus and chronic stable angina; however, it does not explicitly state that ranolazine treats type 2 diabetes mellitus. The results from such a study may suggest potential benefits for patients suffering from both conditions (type 2 diabetes mellitus and chronic stable angina) when treated with ranolazine; nonetheless, it does not provide conclusive evidence that ranolazine is a treatment for type 2 diabetes mellitus in isolation. + The statement indicates that ranolazine can improve exercise-induced myocardial ischaemia and lessen the severity of angina in patients with chronic ischaemic heart disease. This implies that ranolazine has a therapeutic effect on myocardial ischaemia and angina, which are key components of ischaemic heart disease. Therefore, while the statement does not explicitly state that ranolazine" +9302560,Ranolazine treats cardiovascular disorder,1087,Ranolazine is a novel drug that has shown promise in the treatment of cardiovascular disease.,True,"'Does the phrase ""Ranolazine treats cardiovascular disorder"" receive at least indirect support from the statement: ""Ranolazine is a novel drug that has shown promise in the treatment of cardiovascular disease.""?","Yes, the statement ""Ranolazine is a novel drug that has shown promise in the treatment of cardiovascular disease"" does lend indirect support to the phrase ""Ranolazine treats cardiovascular disorder"". This is because the term ""treatment"" implies that there is some beneficial effect in managing or alleviating the disease, while ""promise"" suggests that there is evidence of such beneficial effects in preclinical or clinical studies. However, it is important to note that ""promise"" does not necessarily mean that the treatment is proven to be effective; further rigorous studies may be required for such confirmation. The term ""cardiovascular disorder"" is also more general than ""cardiovascular disease"", but they can be used interchangeably in most contexts as they refer to conditions affecting the heart and blood vessels. In summary, while not definitive proof of ranolazine treating cardiovascular disorders, it does provide support based on the evidence presented in the statement." +27475554,Prednisolone treats microscopic polyangiitis,1088,Microscopic polyarteritis nodosa was diagnosed and therapy with prednisolone was begun.,True,"'Does the phrase ""Prednisolone treats microscopic polyangiitis"" receive at least indirect support from the statement: ""Microscopic polyarteritis nodosa was diagnosed and therapy with prednisolone was begun.""?","Yes, the statement ""Microscopic polyarteritis nodosa was diagnosed and therapy with prednisolone was begun"" does provide indirect support for the claim ""Prednisolone treats microscopic polyangiitis"". This is because microscopic polyarteritis nodosa is considered a form of microscopic polyangiitis (MPA), which is an ANCA-associated vasculitis (AAV) that commonly affects small vessels. Prednisolone is often used as part of standard therapy for AAVs such as MPA due to its anti-inflammatory properties. - A more thorough analysis would require examining additional studies specifically targeting ranolazine as a treatment for type 2 diabetes mellitus without comorbidities like chronic stable angina. This would help establish whether ranolazine has standalone therapeutic potential for type 2 diabetes mellitus patients without any confounding factors related to other medical conditions or drug interactions. + However, it should be emphasized that while there is evidence supporting prednisolone use in treating MPA, it is not necessarily specific to MPA alone as other AAVs may also respond similarly to prednisolone treatment. Moreover, prednisolone is typically used in combination with other immunosuppressive agents for optimal outcomes in MPA treatment. It is also important to consider potential side effects associated with prednisolone use in long-term therapy for MPA management. - It is essential to approach scientific statements cautiously, ensuring that they align with empirical evidence derived from rigorous experimental" -15243162,Ranolazine treats diastolic heart failure,1081,"Moreover, ranolazine holds potential promise to be effective in treatment of atrial fibrillation and diastolic heart failure.",True,"Is the triple 'Ranolazine treats diastolic heart failure' supported by the sentence: 'Moreover, ranolazine holds potential promise to be effective in treatment of atrial fibrillation and diastolic heart failure.'?","Yes, the statement does provide indirect support for the claim that ""Ranolazine treats diastolic heart failure."" The reason is that it mentions ranolazine as having potential effectiveness in treating diastolic heart failure, which implies that there is some evidence or rationale suggesting its use in treating this condition. However, it's important to note that indirect support does not equate to definitive proof, and further investigation would be necessary to confirm ranolazine's efficacy in treating diastolic heart failure." -14672486,Ranolazine treats long QT syndrome,1082,"Small clinical trials suggest that ranolazine may have a role in the treatment of patients with non-ST-elevation acute coronary syndrome, atrial fibrillation, long QT syndromes, and sinus node dysfunction.",True,"Is the triple 'Ranolazine treats long QT syndrome' supported by the sentence: 'Small clinical trials suggest that ranolazine may have a role in the treatment of patients with non-ST-elevation acute coronary syndrome, atrial fibrillation, long QT syndromes, and sinus node dysfunction.'?","Yes, while indirectly, the statement does lend some support to the claim that ranolazine may be used in treating long QT syndrome. Small clinical trials have suggested that ranolazine could play a part in managing patients with non-ST-elevation acute coronary syndrome, atrial fibrillation, long QT syndromes, and sinus node dysfunction. The mention of long QT syndromes in this context implies that there is some evidence pointing towards its potential therapeutic use for this condition; however, it is crucial to examine more robust studies before making definitive conclusions about its efficacy in treating long QT syndrome specifically. + In summary, while there is indirect support for prednisolone being an effective treatment for microscopic poly" +26307899,Prednisolone treats eye disorder,1089,A short trial with high doses of prednisolone to treat a 62 year-old woman with malignant ophthalmopathy due to Graves disease yielded an unsatisfactory improvement after 5-6 days.,False,"'Does the phrase ""Prednisolone treats eye disorder"" receive at least indirect support from the statement: ""A short trial with high doses of prednisolone to treat a 62 year-old woman with malignant ophthalmopathy due to Graves disease yielded an unsatisfactory improvement after 5-6 days.""?","No, the statement does not provide indirect support for the phrase ""Prednisolone treats eye disorder"". The provided statement describes an instance where high doses of prednisolone were used in treating malignant ophthalmopathy due to Graves disease in a 62-year-old woman, but the improvement was unsatisfactory after 5-6 days of treatment. This implies that prednisolone might not be effective in treating eye disorders related to Graves disease within that timeframe at those doses. However, it does not rule out the possibility that prednisolone may be effective under different conditions (e.g., lower doses, longer treatment periods, different types of eye disorders). Therefore, more evidence is needed before making a general claim about prednisolone treating eye disorders." +25942811,Prednisolone treats sympathetic ophthalmia,1090,"[""Abolishment"" syndrome in prednisolone treatment of patients with sympathetic ophthalmia].",True,"'Does the phrase ""Prednisolone treats sympathetic ophthalmia"" receive at least indirect support from the statement: ""[""Abolishment"" syndrome in prednisolone treatment of patients with sympathetic ophthalmia].""?","Yes, the phrase ""Prednisolone treats sympathetic ophthalmia"" does receive indirect support from the statement: ""Abolishment syndrome in prednisolone treatment of patients with sympathetic ophthalmia."" The term ""abolishment"" suggests that there is an elimination or stopping of symptoms associated with sympathetic ophthalmia during prednisolone treatment. This implies that prednisolone has some therapeutic effect on sympathetic ophthalmia. However, it is important to note that indirect support is not as strong as direct evidence from controlled clinical trials that demonstrate both safety and efficacy of prednisolone for treating sympathetic ophthalmia." +24297743,Prednisolone treats exfoliative dermatitis,1091,"A 60-year-old Aboriginal man with underlying severe exfoliative dermatitis, treated with oral azathioprine and oral prednisolone, presented with left painful red eye for ten days.",True,"'Does the phrase ""Prednisolone treats exfoliative dermatitis"" receive at least indirect support from the statement: ""A 60-year-old Aboriginal man with underlying severe exfoliative dermatitis, treated with oral azathioprine and oral prednisolone, presented with left painful red eye for ten days.""?","Yes, the statement does provide indirect support for the claim that prednisolone treats exfoliative dermatitis. The patient in question has exfoliative dermatitis and is being treated with both azathioprine and prednisolone. The fact that both treatments were administered makes it impossible to definitively attribute any improvement solely to prednisolone. However, given that prednisolone is frequently used as an off-label treatment for various forms of dermatitis due to its anti-inflammatory properties, it is reasonable to infer that it may be contributing positively towards managing the patient's exfoliative dermatitis. - Further investigation is necessary because long QT syndrome is a complex genetic disorder that involves various genes responsible for ion channel functioning in cardiac cells. To confidently assert that ranolazine can treat long QT syndrome, researchers should establish its mechanism of action in addressing specific ion channel abnormalities underlying different types of long QT syndrome. This would require thorough preclinical studies followed by large-scale clinical trials that consider various factors such as dosage, duration of treatment, genetic heterogeneity among patients, potential side effects, and interactions with other" -13891593,Ranolazine treats atrial fibrillation,1083,"Recent studies have increased interest in fast-unbinding Na(+) channel blockers like vernakalant (RSD1235) and ranolazine for AF therapy, but the mechanism of efficacy is poorly understood.",False,"Is the triple 'Ranolazine treats atrial fibrillation' supported by the sentence: 'Recent studies have increased interest in fast-unbinding Na(+) channel blockers like vernakalant (RSD1235) and ranolazine for AF therapy, but the mechanism of efficacy is poorly understood.'?","No, the statement does not provide direct or indirect support for the phrase ""Ranolazine treats atrial fibrillation."" The statement mentions that recent studies have increased interest in fast-unbinding Na(+) channel blockers like vernakalant (RSD1235) and ranolazine for atrial fibrillation (AF) therapy. However, it also mentions that the mechanism of efficacy is poorly understood, which implies that there is no clear evidence or understanding of how these drugs treat atrial fibrillation. Therefore, it is not appropriate to conclude that ranolazine treats atrial fibrillation based on this statement alone." -12975239,Ranolazine treats coronary artery disorder,1084,Ranolazine for the management of coronary artery disease.,True,Is the triple 'Ranolazine treats coronary artery disorder' supported by the sentence: 'Ranolazine for the management of coronary artery disease.'?,"Yes, the statement ""Ranolazine for the management of coronary artery disease"" does provide indirect support for the phrase ""Ranolazine treats coronary artery disorder."" This is because treating a disorder is often part of its management. Ranolazine is mentioned as being used in managing coronary artery disease, which implies that it has some therapeutic effect on the disorder itself. However, it is important to note that management can also include other aspects such as prevention, monitoring, or symptom relief, so direct support would require a statement specifically mentioning treatment or curing coronary artery disorder." -10629663,Ranolazine treats Angina pectoris,1085,"Effects of a new metabolic modulator, ranolazine, on exercise tolerance in angina pectoris patients treated with beta-blocker or diltiazem.",True,"Is the triple 'Ranolazine treats Angina pectoris' supported by the sentence: 'Effects of a new metabolic modulator, ranolazine, on exercise tolerance in angina pectoris patients treated with beta-blocker or diltiazem.'?","Yes, the statement does provide indirect support for the claim that ""Ranolazine treats Angina pectoris"". The study mentioned investigates the effects of ranolazine on exercise tolerance in angina pectoris patients who were already being treated with either beta-blockers or diltiazem. The fact that such a study was conducted suggests that there is some basis for believing that ranolazine may have beneficial effects in treating angina pectoris, otherwise there would be no reason to study it in this context. However, it is important to note that indirect support does not equate to definitive proof. The study would need to be evaluated in its entirety, including its design, sample size, statistical analysis, and results, before making any firm conclusions about the efficacy of ranolazine for treating angina pectoris." -9302562,Ranolazine treats myocardial ischemia,1086,Ranolazine has been shown to improve exercise-induced myocardial ischaemia and to lessen the severity of angina in the setting of chronic ischaemic heart disease.,True,Is the triple 'Ranolazine treats myocardial ischemia' supported by the sentence: 'Ranolazine has been shown to improve exercise-induced myocardial ischaemia and to lessen the severity of angina in the setting of chronic ischaemic heart disease.'?,"Yes, the statement ""Ranolazine has been shown to improve exercise-induced myocardial ischaemia and to lessen the severity of angina in the setting of chronic ischaemic heart disease"" does provide indirect support for the claim that ""Ranolazine treats myocardial ischemia"". + It is important to note that correlation does not imply causation; therefore, while prednisolone might be beneficial in treating exfoliative dermatitis based on this statement alone, further evidence would be needed for more conclusive proof of its efficacy in treating this particular condition. This could include controlled clinical trials demonstrating significant improvement in patients receiving prednisolone compared to those on placebo or alternative treatments. - Myocardial ischemia is defined as an insufficient supply of oxygenated blood to the heart muscle, often due to coronary artery disease (CAD). Angina is chest pain caused by reduced blood flow to the heart muscle. Both angina and myocardial ischemia can be symptoms or results of CAD. + In summary, while the statement does lend some indirect support for prednisolone as a treatment for exfoliative" +24291326,Prednisolone treats Anti-neutrophil cytoplasmic antibody-associated vasculitis,1092,"These findings were consistent with a diagnosis of ANCA-associated vasculitis, and treatment with prednisolone markedly improved her condition.",True,"'Does the phrase ""Prednisolone treats Anti-neutrophil cytoplasmic antibody-associated vasculitis"" receive at least indirect support from the statement: ""These findings were consistent with a diagnosis of ANCA-associated vasculitis, and treatment with prednisolone markedly improved her condition.""?","Yes, the phrase ""Prednisolone treats Anti-neutrophil cytoplasmic antibody-associated vasculitis (ANCA-associated vasculitis)"" does receive indirect support from the statement provided. The statement indicates that a patient was diagnosed with ANCA-associated vasculitis and was subsequently treated with prednisolone, resulting in significant improvement of her condition. - The provided statement suggests that ranolazine can improve exercise-induced myocardial ischaemia and lessen angina severity in patients with chronic ischaemic heart disease (which often involves CAD). This implies that ranolazine could potentially treat myocardial ischemia by improving blood flow to the heart muscle and reducing symptoms associated with ischaemia (such as angina). + The connection between these two pieces of information lies in the fact that prednisolone is an immunosuppressive drug often used in the treatment of various vasculitides, including ANCA-associated vasculitis (Chin et al., 2019). The statement provided suggests that prednisolone was effective in managing the symptoms of ANCA-associated vasculitis in this particular case. - However, it is important to note that while the statement provides indirect support for the claim, it does not prove it" -9302560,Ranolazine treats cardiovascular disorder,1087,Ranolazine is a novel drug that has shown promise in the treatment of cardiovascular disease.,True,Is the triple 'Ranolazine treats cardiovascular disorder' supported by the sentence: 'Ranolazine is a novel drug that has shown promise in the treatment of cardiovascular disease.'?,"Yes, the statement ""Ranolazine is a novel drug that has shown promise in the treatment of cardiovascular disease"" does lend indirect support to the phrase ""Ranolazine treats cardiovascular disorder"". The use of the word ""treatment"" implies that there is evidence suggesting that Ranolazine can be used as a therapeutic option for cardiovascular disease. The term ""has shown promise"" further strengthens this inference by indicating that positive outcomes have been observed in studies involving Ranolazine as a treatment for cardiovascular disease. + However, it is important to note that this statement only provides anecdotal evidence of prednisolone's effectiveness in treating ANCA-associated vasculitis. To establish more robust support for the claim that prednisolone treats ANCA-associated vasculitis, randomized controlled trials (RCTs) would need to be conducted that compare prednisolone" +24042094,Prednisolone treats biliary atresia,1093,"In 2010, a study on the advantages of budesonide compared to prednisolone in autoimmune hepatitis gave rise to experimental therapy using budesonide as an adjuvant BA treatment.",False,"'Does the phrase ""Prednisolone treats biliary atresia"" receive at least indirect support from the statement: ""In 2010, a study on the advantages of budesonide compared to prednisolone in autoimmune hepatitis gave rise to experimental therapy using budesonide as an adjuvant BA treatment.""?","No, the statement does not provide indirect support for the phrase ""Prednisolone treats biliary atresia."" The study mentioned is about autoimmune hepatitis and compares budesonide with prednisolone as potential treatments for that specific condition. Biliary atresia is a different liver disease, unrelated to autoimmune hepatitis. Therefore, conclusions drawn from autoimmune hepatitis studies cannot be directly applied to biliary atresia regarding prednisolone's effectiveness as a treatment option. - However, it is important to note that ""promise"" does not necessarily equate to ""proven efficacy"". The evidence supporting Ranolazine as a treatment for cardiovascular disease may still be preliminary or not conclusive. Therefore, while there is some level of support for the claim that Ranolazine treats cardiovascular disorder based on the given statement, it would be more accurate to describe Ranolazine as a potential or promising treatment rather than a definitive one. + However, it is important to acknowledge that both prednisolone and budesonide belong to a class of drugs called corticosteroids which might have similar effects on various liver diseases due to their anti-inflammatory properties. Nonetheless, without explicit evidence indicating prednisolone's efficacy in treating biliary atresia, one cannot infer its benefits in managing that condition based on the given statement alone." +23981131,Prednisolone treats mycosis fungoides,1094,Prednisolone was initially used alone as an alternative treatment for CEL.,True,"'Does the phrase ""Prednisolone treats mycosis fungoides"" receive at least indirect support from the statement: ""Prednisolone was initially used alone as an alternative treatment for CEL.""?","Yes, there is indirect support for the statement ""Prednisolone treats mycosis fungoides"" from ""Prednisolone was initially used alone as an alternative treatment for CEL."" This is because both mycosis fungoides (MF) and Cutaneous T-cell Lymphoma (CEL) are types of lymphoma that affect the skin, and they share some common treatment approaches. - To further evaluate the claim, additional information about the nature and quality of the studies showing promise would be required. This could include details about the study" -27475554,Prednisolone treats microscopic polyangiitis,1088,Microscopic polyarteritis nodosa was diagnosed and therapy with prednisolone was begun.,True,Is the triple 'Prednisolone treats microscopic polyangiitis' supported by the sentence: 'Microscopic polyarteritis nodosa was diagnosed and therapy with prednisolone was begun.'?,"Yes, the statement ""Microscopic polyarteritis nodosa was diagnosed and therapy with prednisolone was begun"" does provide indirect support for the claim ""Prednisolone treats microscopic polyangiitis"". This is because microscopic polyarteritis nodosa is considered a form of microscopic polyangiitis (MPA), which is an ANCA-associated vasculitis that primarily affects small blood vessels [1]. Prednisolone is often used as part of standard treatment regimens for MPA [2]. - - However, it is important to note that correlation does not imply causation; therefore, while prednisolone is used in treating MPA, it does not necessarily mean that prednisolone is solely responsible for treating MPA. Other factors such as immunosuppressive therapy may also be used concurrently for optimal management [3]. Additionally, potential side effects from prednisolone should be taken into account when considering its use as therapy for MPA patients [4]. - - In summary, while there is indirect support for prednisolone being used as treatment for microscopic polyangiitis based on the provided statement, it is crucial to consider" -26307899,Prednisolone treats eye disorder,1089,A short trial with high doses of prednisolone to treat a 62 year-old woman with malignant ophthalmopathy due to Graves disease yielded an unsatisfactory improvement after 5-6 days.,False,Is the triple 'Prednisolone treats eye disorder' supported by the sentence: 'A short trial with high doses of prednisolone to treat a 62 year-old woman with malignant ophthalmopathy due to Graves disease yielded an unsatisfactory improvement after 5-6 days.'?,"No, the statement does not provide indirect support for the phrase ""Prednisolone treats eye disorder"". In fact, it suggests that prednisolone may be less effective in treating certain eye disorders, such as malignant ophthalmopathy due to Graves disease, at least in high doses over short trial periods. The evidence provided indicates an unsatisfactory improvement after 5-6 days of treatment. + Prednisolone is a corticosteroid that has anti-inflammatory and immunosuppressive properties. It has been used in various dermatological conditions including lymphomas such as CEL due to its ability to modulate immune responses and reduce inflammation. Mycosis fungoides is another type of cutaneous lymphoma that could potentially respond to similar therapeutic approaches. - However, it is important to note that treatment response can vary significantly among patients due to factors like age, sex, disease severity, genetic predisposition, and concomitant medications. Furthermore, prednisolone has been shown to be beneficial in treating various eye disorders in other contexts. Therefore, one negative outcome does not negate prednisolone's overall efficacy in treating eye disorders but rather highlights specific situations where its effectiveness may be limited. + + However, it is important to note that although there is indirect support based on shared disease characteristics and treatment modalities, direct clinical evidence specifically linking prednisolone as an effective treatment for mycosis fungoides may still be necessary for stronger substantiation. This example only highlights the potential for prednisolone" +23374627,Prednisolone treats trichinellosis,1095,"This study assessed the antiparasitic and anti-inflammatory effects of Citrus limon and Capsicum frutescens on murine trichinellosis and compared them with those of albendazole and prednisolone, which are conventionally used to treat trichinellosis.",True,"'Does the phrase ""Prednisolone treats trichinellosis"" receive at least indirect support from the statement: ""This study assessed the antiparasitic and anti-inflammatory effects of Citrus limon and Capsicum frutescens on murine trichinellosis and compared them with those of albendazole and prednisolone, which are conventionally used to treat trichinellosis.""?","Yes, the statement does provide indirect support for the claim that prednisolone treats trichinellosis. The study mentioned assesses the effects of prednisolone in relation to trichinellosis, which implies that prednisolone is being used as a treatment for trichinellosis in the context of the study. However, it is important to note that indirect support does not equate to definitive proof. The claim should be further evaluated in consideration of other evidence and factors, such as dosage, side effects, and potential interactions with other medications or health conditions." +22580782,Prednisolone treats interstitial lung disease 2,1096,Regression of Lung Squamous Cell Carcinoma after the Withdrawal of Cyclosporin A Combined With Pirfenidone Treatment in a Patient with Idiopathic Pulmonary Fibrosis.A 72-year-old man was treated with prednisolone and cyclosporine A for idiopathic pulmonary fibrosis.,False,"'Does the phrase ""Prednisolone treats interstitial lung disease 2"" receive at least indirect support from the statement: ""Regression of Lung Squamous Cell Carcinoma after the Withdrawal of Cyclosporin A Combined With Pirfenidone Treatment in a Patient with Idiopathic Pulmonary Fibrosis.A 72-year-old man was treated with prednisolone and cyclosporine A for idiopathic pulmonary fibrosis.""?","No, the statement does not provide direct or indirect support for the claim that ""Prednisolone treats interstitial lung disease 2."" The statement mentions that a patient with idiopathic pulmonary fibrosis was treated with prednisolone and cyclosporine A; however, it does not provide any information about the outcomes of prednisolone treatment specifically for interstitial lung disease 2. The study focuses on regression of lung squamous cell carcinoma after withdrawal of cyclosporin A combined with pirfenidone treatment in a patient with idiopathic pulmonary fibrosis. - In conclusion, while prednisolone may be an option for treating eye disorders in some cases, more extensive studies would be required to establish its overall efficacy in different patient populations and clinical scenarios." -25942811,Prednisolone treats sympathetic ophthalmia,1090,"[""Abolishment"" syndrome in prednisolone treatment of patients with sympathetic ophthalmia].",True,"Is the triple 'Prednisolone treats sympathetic ophthalmia' supported by the sentence: '[""Abolishment"" syndrome in prednisolone treatment of patients with sympathetic ophthalmia].'?","Yes, the phrase ""Prednisolone treats sympathetic ophthalmia"" does receive indirect support from the statement: ""Abolishment syndrome in prednisolone treatment of patients with sympathetic ophthalmia."" + + To establish indirect support for the claim that prednisolone treats interstitial lung disease 2, one would need evidence suggesting that treating idiopathic pulmonary fibrosis (or another lung condition) with prednisolone leads to improvements in interstitial lung disease 2. Since there is no such information in the provided statement, we cannot infer support for that claim based on this evidence alone." +22500116,Prednisolone treats HIV infectious disease,1097,"The most common coexisting conditions were HIV infection (30%), prednisolone therapy (16.9%), and diabetes mellitus (15.7%).",False,"'Does the phrase ""Prednisolone treats HIV infectious disease"" receive at least indirect support from the statement: ""The most common coexisting conditions were HIV infection (30%), prednisolone therapy (16.9%), and diabetes mellitus (15.7%).""?","No, the statement does not provide indirect support for the phrase ""Prednisolone treats HIV infectious disease"". The provided statement only mentions that HIV infection (30%) and prednisolone therapy (16.9%) coexist in some cases; it does not imply that prednisolone has any therapeutic effect on HIV infection. In fact, prednisolone is an immunosuppressant drug often used to treat inflammatory diseases, which could potentially worsen an HIV patient's condition by further weakening their immune system. Therefore, one should be cautious when interpreting such correlations as causations without concrete evidence from well-designed studies." +22130331,Prednisolone treats schizophrenia,1098,"Therefore, the effect of prednisolone can be studied as a proof of concept for immune modulation as a treatment for schizophrenia.",False,"'Does the phrase ""Prednisolone treats schizophrenia"" receive at least indirect support from the statement: ""Therefore, the effect of prednisolone can be studied as a proof of concept for immune modulation as a treatment for schizophrenia.""?","No, the statement does not provide indirect support for the phrase ""Prednisolone treats schizophrenia."" The statement suggests that prednisolone can be used as a model for studying immune modulation as a potential treatment for schizophrenia. This implies that prednisolone may help us understand the mechanisms of immune modulation in schizophrenia treatment, but it does not necessarily mean that prednisolone itself is an effective treatment for schizophrenia. - The term ""abolishment"" suggests that something is being eliminated or stopped, which in this context would be the symptoms or progression of sympathetic ophthalmia. The fact that prednisolone is mentioned in conjunction with this abolishment implies that it plays a significant role in treating or managing the condition. Therefore, it can be inferred that prednisolone has some therapeutic effect on sympathetic ophthalmia. However, it is important to note that direct evidence from randomized controlled trials would provide stronger support for this claim." -24297743,Prednisolone treats exfoliative dermatitis,1091,"A 60-year-old Aboriginal man with underlying severe exfoliative dermatitis, treated with oral azathioprine and oral prednisolone, presented with left painful red eye for ten days.",True,"Is the triple 'Prednisolone treats exfoliative dermatitis' supported by the sentence: 'A 60-year-old Aboriginal man with underlying severe exfoliative dermatitis, treated with oral azathioprine and oral prednisolone, presented with left painful red eye for ten days.'?","Yes, the statement does provide indirect support for the claim that prednisolone treats exfoliative dermatitis. The patient in question has exfoliative dermatitis and is being treated with both azathioprine and prednisolone. The fact that they were prescribed prednisolone suggests that it is considered an effective treatment for their condition. However, it is important to note that correlation does not imply causation, so while prednisolone is being used in conjunction with improved health outcomes for this patient, it does not definitively prove that prednisolone is the causative agent for these improvements. Additionally, other factors such as the azathioprine treatment could also be contributing to the patient's improvement." -24291326,Prednisolone treats Anti-neutrophil cytoplasmic antibody-associated vasculitis,1092,"These findings were consistent with a diagnosis of ANCA-associated vasculitis, and treatment with prednisolone markedly improved her condition.",True,"Is the triple 'Prednisolone treats Anti-neutrophil cytoplasmic antibody-associated vasculitis' supported by the sentence: 'These findings were consistent with a diagnosis of ANCA-associated vasculitis, and treatment with prednisolone markedly improved her condition.'?","Yes, the phrase ""Prednisolone treats Anti-neutrophil cytoplasmic antibody-associated vasculitis (ANCA-associated vasculitis)"" does receive indirect support from the statement: ""These findings were consistent with a diagnosis of ANCA-associated vasculitis, and treatment with prednisolone markedly improved her condition."" + The misconception might arise from conflating the use of prednisolone as a tool for studying immune modulation (a potential treatment approach) with prednisolone being an actual treatment for schizophrenia. While studying its effects could potentially lead to advancements in immunotherapy for schizophrenia, it does not confirm that prednisolone itself is an effective treatment for the disorder. Therefore, more research would be needed to establish whether prednisolone has therapeutic value in treating schizophrenia." +21634207,Prednisolone treats chronic primary adrenal insufficiency,1099,The patient started insulin therapy and treatment for AD with prednisolone and fludrocortisone with good clinical response.,True,"'Does the phrase ""Prednisolone treats chronic primary adrenal insufficiency"" receive at least indirect support from the statement: ""The patient started insulin therapy and treatment for AD with prednisolone and fludrocortisone with good clinical response.""?","Yes, there is indirect support for the statement that prednisolone treats chronic primary adrenal insufficiency (AI). The user statement indicates that a patient diagnosed with AI was treated with prednisolone in combination with fludrocortisone and insulin therapy, which resulted in a good clinical response. - The statement provides evidence that prednisolone was used as a treatment for ANCA-associated vasculitis and that it led to significant improvement in the patient's condition. While not a direct causal link between prednisolone and treatment of ANCA-associated vasculitis, it does suggest that prednisolone may be an effective treatment for this condition based on these observed outcomes. + Prednisolone is a synthetic glucocorticoid often used in AI treatment due to its ability to mimic cortisol action in the body by binding to glucocorticoid receptors in various tissues (Arlt 2009). The positive clinical response observed in this case suggests that prednisolone has contributed to managing AI symptoms effectively. - However, it is important to note that this evidence is based on an individual case study rather than a controlled clinical trial, so further investigation would be needed before making definitive conclusions about prednisolone as an effective treatment for ANCA-associated vasculitis in general. Nonetheless, it does provide some support for the claim that prednisolone could be used as a treatment for ANCA-associated vasculitis" -24042094,Prednisolone treats biliary atresia,1093,"In 2010, a study on the advantages of budesonide compared to prednisolone in autoimmune hepatitis gave rise to experimental therapy using budesonide as an adjuvant BA treatment.",False,"Is the triple 'Prednisolone treats biliary atresia' supported by the sentence: 'In 2010, a study on the advantages of budesonide compared to prednisolone in autoimmune hepatitis gave rise to experimental therapy using budesonide as an adjuvant BA treatment.'?","No, the statement does not provide indirect support for the claim that ""Prednisolone treats biliary atresia"". The study mentioned is about autoimmune hepatitis, not biliary atresia. It compares budesonide to prednisolone in terms of advantages in treating autoimmune hepatitis. The use of budesonide as an adjuvant in biliary atresia treatment is an experimental therapy, but there is no mention of prednisolone being used for biliary atresia treatment in this context." -23981131,Prednisolone treats mycosis fungoides,1094,Prednisolone was initially used alone as an alternative treatment for CEL.,False,Is the triple 'Prednisolone treats mycosis fungoides' supported by the sentence: 'Prednisolone was initially used alone as an alternative treatment for CEL.'?,"No, the statement ""Prednisolone was initially used alone as an alternative treatment for CEL"" does not provide indirect support for the claim that ""Prednisolone treats mycosis fungoides."" This is because CEL (cutaneous T-cell lymphoma) is not the same as mycosis fungoides (MF), although MF is one type of CEL. The statement only supports that prednisolone might be an alternative treatment for some forms of CEL, not specifically for MF. The two conditions, while related, still require individual evaluation when considering treatment options due to their distinct characteristics." -23374627,Prednisolone treats trichinellosis,1095,"This study assessed the antiparasitic and anti-inflammatory effects of Citrus limon and Capsicum frutescens on murine trichinellosis and compared them with those of albendazole and prednisolone, which are conventionally used to treat trichinellosis.",True,"Is the triple 'Prednisolone treats trichinellosis' supported by the sentence: 'This study assessed the antiparasitic and anti-inflammatory effects of Citrus limon and Capsicum frutescens on murine trichinellosis and compared them with those of albendazole and prednisolone, which are conventionally used to treat trichinellosis.'?","Yes, the statement does provide indirect support for the claim that prednisolone treats trichinellosis. The study mentioned assesses the effects of prednisolone in treating murine trichinellosis, which is a step towards validating its use in treating trichinellosis. However, it is important to note that indirect support does not equate to definitive proof; further studies would be required to confirm prednisolone's efficacy in treating trichinellosis in humans conclusively." -22580782,Prednisolone treats interstitial lung disease 2,1096,Regression of Lung Squamous Cell Carcinoma after the Withdrawal of Cyclosporin A Combined With Pirfenidone Treatment in a Patient with Idiopathic Pulmonary Fibrosis.A 72-year-old man was treated with prednisolone and cyclosporine A for idiopathic pulmonary fibrosis.,False,Is the triple 'Prednisolone treats interstitial lung disease 2' supported by the sentence: 'Regression of Lung Squamous Cell Carcinoma after the Withdrawal of Cyclosporin A Combined With Pirfenidone Treatment in a Patient with Idiopathic Pulmonary Fibrosis.A 72-year-old man was treated with prednisolone and cyclosporine A for idiopathic pulmonary fibrosis.'?,"No, the statement does not provide direct or indirect support for the claim that prednisolone treats interstitial lung disease (ILD) specifically. The provided statement discusses a case where a patient with idiopathic pulmonary fibrosis (ILD) was treated using prednisolone and cyclosporine A; however, it does not establish a causal link between prednisolone use and improvement in ILD symptoms. + However, it is essential to note that AI treatment typically involves a combination of therapies tailored according to individual patient needs. In this case, fludrocortisone is used alongside prednisolone as it plays an essential role in correcting mineralocorticoid deficiency often present in AI patients (Newell-Price et al., 2019). Insulin therapy is also mentioned in the user statement; however, it is not typically associated with AI management but may be required if concurrent conditions" +21254689,Prednisolone treats hypersensitivity pneumonitis,1100,We aimed to determine the effect of mycophenolate mofetil (MMF) and azathioprine (AZA) on lung function and prednisolone dose in cHP patients.,False,"'Does the phrase ""Prednisolone treats hypersensitivity pneumonitis"" receive at least indirect support from the statement: ""We aimed to determine the effect of mycophenolate mofetil (MMF) and azathioprine (AZA) on lung function and prednisolone dose in cHP patients.""?","No, the statement does not provide indirect support for the phrase ""Prednisolone treats hypersensitivity pneumonitis."" The study mentioned in the statement is investigating the effect of mycophenolate mofetil (MMF) and azathioprine (AZA) on lung function and prednisolone dose in chronic hypersensitivity pneumonitis (cHP) patients. Although prednisolone is mentioned in the statement, there is no information provided about its efficacy in treating hypersensitivity pneumonitis. Therefore, it is not appropriate to infer that prednisolone is an effective treatment based on this statement alone." +20836940,Prednisolone treats juvenile idiopathic arthritis,1101,"Here, we report the case of an 8-year-old girl with a 5-year history of multiple subcutaneous nodules on her extremities and a right wrist joint contracture who had been previously diagnosed with juvenile idiopathic arthritis and treated with salazosulfapyridine, low-dose prednisolone (PSL) and methotrexate.",True,"'Does the phrase ""Prednisolone treats juvenile idiopathic arthritis"" receive at least indirect support from the statement: ""Here, we report the case of an 8-year-old girl with a 5-year history of multiple subcutaneous nodules on her extremities and a right wrist joint contracture who had been previously diagnosed with juvenile idiopathic arthritis and treated with salazosulfapyridine, low-dose prednisolone (PSL) and methotrexate.""?","Yes, the statement does provide indirect support for the claim that prednisolone treats juvenile idiopathic arthritis. The key phrase here is ""who had been previously diagnosed with juvenile idiopathic arthritis and treated with ... low-dose prednisolone."" This implies that prednisolone is one of the treatments used for juvenile idiopathic arthritis in this particular case. - Additionally, idiopathic pulmonary fibrosis is only one type of interstitial lung disease among many others. The specific type of ILD should be considered when interpreting evidence related to its treatment. + However, it is important to note that while this provides some evidence for the claim, it does not constitute direct evidence. This is because the statement does not explicitly state that prednisolone was responsible for any improvement in symptoms. It only confirms its use in treatment. Therefore, further evidence would be needed to definitively support the claim that prednisolone treats juvenile idiopathic arthritis. - In summary, while prednisolone may have been used in treating ILD in this particular case study, it does not necessarily mean that prednisolone is an effective treatment for interstitial lung disease in general without further investigation into its efficacy in treating specific types of ILD in controlled studies." -22500116,Prednisolone treats HIV infectious disease,1097,"The most common coexisting conditions were HIV infection (30%), prednisolone therapy (16.9%), and diabetes mellitus (15.7%).",False,"Is the triple 'Prednisolone treats HIV infectious disease' supported by the sentence: 'The most common coexisting conditions were HIV infection (30%), prednisolone therapy (16.9%), and diabetes mellitus (15.7%).'?","No, the statement does not provide direct or indirect support for the claim that prednisolone treats HIV infectious disease. The provided statement only indicates that HIV infection (30%) and prednisolone therapy (16.9%) were among the most common coexisting conditions in a specific population but does not establish any causal relationship between prednisolone therapy and improvement in HIV infection status. + Additionally, it should be noted that medical treatments often involve complex interactions between multiple factors, including other medications and individual patient characteristics. Therefore, while prednisolone may be an effective treatment for some patients with juvenile idiopathic arthritis, it may not be effective for all patients." +20612701,Prednisolone treats myocarditis,1102,This is a case of EGPA relapse presenting as myocarditis despite treatment with prednisolone.,True,"'Does the phrase ""Prednisolone treats myocarditis"" receive at least indirect support from the statement: ""This is a case of EGPA relapse presenting as myocarditis despite treatment with prednisolone.""?","Yes, indirectly it does lend some support. The statement ""This is a case of EGPA (Eosinophilic Granulomatosis with Polyangiitis) relapse presenting as myocarditis despite treatment with prednisolone"" suggests that although prednisolone was used as a treatment for myocarditis (inflammation of the heart muscle), it did not prevent the relapse of EGPA which presented as myocarditis. This implies that prednisolone may not be fully effective in treating myocarditis in the context of EGPA relapse. However, it does not rule out the possibility that prednisolone could be effective in treating myocarditis not associated with EGPA relapse. Therefore, while not definitive proof, this statement does provide some indirect support for the idea that prednisolone can be used in treating myocarditis, but it may not be effective in all cases, particularly those associated with EGPA relapse." +17604301,Prednisolone treats cataract,1103,"Her visual acuity remained stable, despite development of a cataract from prednisolone therapy.",False,"'Does the phrase ""Prednisolone treats cataract"" receive at least indirect support from the statement: ""Her visual acuity remained stable, despite development of a cataract from prednisolone therapy.""?","No, the statement ""Her visual acuity remained stable, despite development of a cataract from prednisolone therapy"" does not provide direct or indirect support for the phrase ""Prednisolone treats cataract."" In fact, it suggests the opposite. - To further explain, let us consider some essential aspects related to interpreting scientific statements: + Prednisolone is a corticosteroid often used to reduce inflammation. The statement indicates that despite its use (and subsequent development of a cataract), the individual's visual acuity remained stable. This implies that prednisolone did not treat the cataract but was associated with its development. A treatment would typically improve or resolve the condition, not cause it. Therefore, this statement does not support the claim that prednisolone treats cataracts but rather suggests it may contribute to their development." +17312178,Prednisolone treats type 2 diabetes mellitus,1104,"In this study, we hypothesized that concomitant administration of the dipeptidyl peptidase-4 inhibitor sitagliptin and prednisolone in men at high risk to develop type 2 diabetes could protect against the GC-induced diabetogenic effects.",True,"'Does the phrase ""Prednisolone treats type 2 diabetes mellitus"" receive at least indirect support from the statement: ""In this study, we hypothesized that concomitant administration of the dipeptidyl peptidase-4 inhibitor sitagliptin and prednisolone in men at high risk to develop type 2 diabetes could protect against the GC-induced diabetogenic effects.""?","Yes, indirectly it does lend some support. The statement from the study suggests that prednisolone may have diabetogenic effects when administered alone in men at high risk for type 2 diabetes. However, they propose that when combined with sitagliptin, an agent known to enhance insulin secretion, these diabetogenic effects could be mitigated. This implies that prednisolone might still play a role in managing type 2 diabetes when used in combination therapy, which aligns with the phrase in question. However, it's important to note that this is an indirect inference based on a hypothetical scenario; further evidence is needed to directly support the claim that prednisolone treats type 2 diabetes mellitus." +17184322,Prednisolone treats croup,1105,"Although common practice, evidence to support treatment of croup with prednisolone is scant.",False,"'Does the phrase ""Prednisolone treats croup"" receive at least indirect support from the statement: ""Although common practice, evidence to support treatment of croup with prednisolone is scant.""?","No, the statement ""Although common practice, evidence to support treatment of croup with prednisolone is scant"" does not provide indirect support for the phrase ""Prednisolone treats croup."" In fact, it suggests quite the opposite. The phrase ""evidence to support treatment...is scant"" implies that there is limited scientific backing for using prednisolone as a treatment for croup. Common practice does not necessarily equate to evidence-based practice, and in this case, it seems that the widespread use of prednisolone for croup treatment may be more tradition-based than supported by robust scientific evidence. Therefore, without stronger evidence supporting its use, it would be inaccurate to claim that prednisolone treats croup based on this statement alone." +16852549,Prednisolone treats mature T-cell and NK-cell non-Hodgkin lymphoma,1106,"Treatment of peripheral T cell lymphoma with an intensive protocol ACEP (adriamycin, cyclophosphamide, etoposide and prednisolone) and ifosfamide showing an important response and overall survival rates.",True,"'Does the phrase ""Prednisolone treats mature T-cell and NK-cell non-Hodgkin lymphoma"" receive at least indirect support from the statement: ""Treatment of peripheral T cell lymphoma with an intensive protocol ACEP (adriamycin, cyclophosphamide, etoposide and prednisolone) and ifosfamide showing an important response and overall survival rates.""?","Yes, there is indirect support for the statement that prednisolone treats mature T-cell and NK-cell non-Hodgkin lymphoma based on the provided evidence. The statement indicates that an intensive protocol ACEP (adriamycin, cyclophosphamide, etoposide, and prednisolone) along with ifosfamide has shown important response rates and overall survival rates in treating peripheral T cell lymphoma. Prednisolone is one of the components of protocol ACEP; thus, it suggests that prednisolone contributes to the treatment of mature T-cell non-Hodgkin lymphoma as part of that combination regimen. However, it is essential to consider that prednisolone may not necessarily be effective independently for treating non-Hodgkin lymphoma but rather as part of a more extensive treatment protocol involving other drugs such as adriamycin, cyclophosphamide, etoposide, and ifosfamide." +16360878,Prednisolone treats ophthalmic herpes zoster,1107,"Herpes zoster ophthalmicus was suspected and treatment with i.v. acyclovir and prednisolone was commenced, which led to a gradual improvement of the clinical condition.",True,"'Does the phrase ""Prednisolone treats ophthalmic herpes zoster"" receive at least indirect support from the statement: ""Herpes zoster ophthalmicus was suspected and treatment with i.v. acyclovir and prednisolone was commenced, which led to a gradual improvement of the clinical condition.""?","Yes, the statement does provide indirect support for the claim that prednisolone treats ophthalmic herpes zoster (herpes zoster ophthalmicus). The statement indicates that treatment involving prednisolone was initiated when herpes zoster ophthalmicus was suspected, and this was followed by gradual improvement in the clinical condition. The association between prednisolone administration and clinical improvement suggests that prednisolone may have contributed to the improvement, providing some level of indirect support for its efficacy in treating ophthalmic herpes zoster. - 1. Correlation vs causation: The statement only highlights that HIV infection and prednisolone therapy frequently co-occur in this dataset; however, it does not prove that prednisolone therapy causes improvements in HIV infection status. - - 2. Context: The study population might have underlying health conditions requiring prednisolone treatment; thus, it is not surprising that prednisolone therapy is prevalent in this dataset. This does not necessarily mean that prednisolone treats HIV infection but rather that it might be prescribed for other concurrent conditions. - - 3. Scientific plausibility: Prednisolone is primarily an anti-inflammatory medication used for various conditions such as" -22130331,Prednisolone treats schizophrenia,1098,"Therefore, the effect of prednisolone can be studied as a proof of concept for immune modulation as a treatment for schizophrenia.",False,"Is the triple 'Prednisolone treats schizophrenia' supported by the sentence: 'Therefore, the effect of prednisolone can be studied as a proof of concept for immune modulation as a treatment for schizophrenia.'?","No, the phrase ""Prednisolone treats schizophrenia"" does not receive at least indirect support from the statement: ""Therefore, the effect of prednisolone can be studied as a proof of concept for immune modulation as a treatment for schizophrenia."" + However, it is important to note that correlation does not necessarily imply causation. The improvement in clinical condition could be attributed to other factors such as the administration of i.v. acyclovir, natural progression of the disease, or other interventions that were not specified in the statement. To establish a more definitive causal relationship between prednisolone treatment and improvement in ophthalmic herpes zoster, further studies controlling for these potential confounding factors would be required." +15441636,Prednisolone treats lipoma,1108,"Lipomas responded with less lipolysis to isoproterenol than subcutaneous fat during microdialysis, and prednisolone treatment increased lipolysis in both lipomas and subcutaneous fat.",True,"'Does the phrase ""Prednisolone treats lipoma"" receive at least indirect support from the statement: ""Lipomas responded with less lipolysis to isoproterenol than subcutaneous fat during microdialysis, and prednisolone treatment increased lipolysis in both lipomas and subcutaneous fat.""?","Yes, indirectly it does lend some support to the statement ""Prednisolone treats lipoma"". The provided statement suggests that prednisolone can influence lipolysis in both lipomas and subcutaneous fat, implying that prednisolone has an effect on lipoma tissue. However, it does not explicitly state that prednisolone treats lipoma, as treating implies resolution or improvement of the condition, not just an effect on it. Therefore, while there is some indirect support based on the biological effect of prednisolone on lipoma tissue, further evidence would be needed to fully support the claim that prednisolone treats lipoma." +15369817,Prednisolone treats pericarditis,1109,Treatment with prednisolone improved the pericarditis and motor nerve disturbance and the treatment with intravenous immunoglobulin improved the sensory nerve disturbance.,True,"'Does the phrase ""Prednisolone treats pericarditis"" receive at least indirect support from the statement: ""Treatment with prednisolone improved the pericarditis and motor nerve disturbance and the treatment with intravenous immunoglobulin improved the sensory nerve disturbance.""?","Yes, the phrase ""Prednisolone treats pericarditis"" does receive indirect support from the statement provided. - My justification for this decision is based on the following points: + The statement indicates that treatment with prednisolone improved the pericarditis in a patient who was suffering from both pericarditis and motor nerve disturbance. This suggests that prednisolone had a positive effect on the pericarditis specifically, providing indirect evidence for its use in treating this condition. - 1) The statement suggests that prednisolone is being considered as a tool for studying immune modulation in relation to schizophrenia treatment, not as a direct treatment itself. It implies that prednisolone may be helpful in understanding potential immune-related aspects that could contribute to the development of new treatments for schizophrenia; + However, it is important to note that this is an indirect inference based on one observation in an unspecified clinical context. A more robust evaluation of prednisolone as a treatment for pericarditis would require controlled clinical trials that compare its effectiveness against other treatments or placebo controls. - 2) The statement does not provide information on prednisolone's effectiveness in treating schizophrenia symptoms directly; + Furthermore, while prednisolone may have improved the pericarditis in this case, it is also possible that other factors not mentioned in the statement contributed to this improvement. Therefore, while the statement provides some support for prednisolone as a treatment for pericarditis, it does not conclusively prove its efficacy." +15104714,Prednisolone treats pulmonary eosinophilia,1110,"Airway macrophage median percentage of red-hued area in stained sputum cytospin preparations was assessed by means of image analysis from (1) subjects with mild-to-severe asthma, subjects with nonasthmatic eosinophilic bronchitis, and healthy control subjects; (2) subjects with eosinophilic severe asthma after treatment with prednisolone; and (3) subject with noneosinophilic asthma before corticosteroid withdrawal.",True,"'Does the phrase ""Prednisolone treats pulmonary eosinophilia"" receive at least indirect support from the statement: ""Airway macrophage median percentage of red-hued area in stained sputum cytospin preparations was assessed by means of image analysis from (1) subjects with mild-to-severe asthma, subjects with nonasthmatic eosinophilic bronchitis, and healthy control subjects; (2) subjects with eosinophilic severe asthma after treatment with prednisolone; and (3) subject with noneosinophilic asthma before corticosteroid withdrawal.""?","Yes, there is indirect support for the claim that prednisolone treats pulmonary eosinophilia based on the statement provided. This support comes from the fact that airway macrophages in subjects with eosinophilic severe asthma showed changes in red-hued area percentage in stained sputum cytospin preparations after treatment with prednisolone. - 3) Prednisolone is an anti-inflammatory medication primarily used for treating various conditions such as allergies, asthma, and autoimmune disorders - not schizophrenia itself; + To elaborate on why I consider this indirect support for prednisolone treating pulmonary eosinophilia, let us first define pulmonary eosinophilia as an increase in eosinophils (a type of white blood cell) in the lung tissue. Prednisolone is a corticosteroid that reduces inflammation in various parts of the body including the lungs by decreasing the production of substances that cause inflammation in response to an allergen or infection. - 4) Although some studies suggest there might be an association between inflammation and schizophrenia, more rig" -21634207,Prednisolone treats chronic primary adrenal insufficiency,1099,The patient started insulin therapy and treatment for AD with prednisolone and fludrocortisone with good clinical response.,True,Is the triple 'Prednisolone treats chronic primary adrenal insufficiency' supported by the sentence: 'The patient started insulin therapy and treatment for AD with prednisolone and fludrocortisone with good clinical response.'?,"Yes, the statement does provide indirect support for the phrase ""Prednisolone treats chronic primary adrenal insufficiency"". The patient's good clinical response after starting treatment with prednisolone suggests that prednisolone is effective in managing adrenal insufficiency (AD). However, it should be noted that the patient was also taking fludrocortisone and insulin therapy concurrently, making it impossible to attribute the positive response solely to prednisolone based on this information alone. Nonetheless, there is some level of support for prednisolone's efficacy in treating AD from this statement." -21254689,Prednisolone treats hypersensitivity pneumonitis,1100,We aimed to determine the effect of mycophenolate mofetil (MMF) and azathioprine (AZA) on lung function and prednisolone dose in cHP patients.,False,Is the triple 'Prednisolone treats hypersensitivity pneumonitis' supported by the sentence: 'We aimed to determine the effect of mycophenolate mofetil (MMF) and azathioprine (AZA) on lung function and prednisolone dose in cHP patients.'?,"No, the statement does not provide direct or indirect support for the claim that ""Prednisolone treats hypersensitivity pneumonitis."" The study investigates the effects of mycophenolate mofetil (MMF) and azathioprine (AZA) on lung function and prednisolone dose in chronic hypersensitivity pneumonitis (cHP) patients but does not provide evidence on prednisolone's effectiveness in treating hypersensitivity pneumonitis. + In the given statement, it is mentioned that airway macrophages in subjects with eosinophilic severe asthma were assessed before and after treatment with prednisolone. If we assume that red-hued areas in" +14992803,Prednisolone treats aplastic anemia,1111,"We report a case of subcutaneous abscess caused by Nocardia farcinica in a 44-year-old man, who had been treated with systemic prednisolone and cyclosporin for aplastic anemia.",True,"'Does the phrase ""Prednisolone treats aplastic anemia"" receive at least indirect support from the statement: ""We report a case of subcutaneous abscess caused by Nocardia farcinica in a 44-year-old man, who had been treated with systemic prednisolone and cyclosporin for aplastic anemia.""?","Yes, indirect support can be inferred from the statement. The claim ""Prednisolone treats aplastic anemia"" is not explicitly stated in the provided text but can be implied given that prednisolone was administered as part of the treatment regimen for aplastic anemia in this case. However, it is important to note that prednisolone may not be the sole treatment for aplastic anemia; rather, it might be used in combination with other drugs like cyclosporin, as mentioned in the statement. Furthermore, while prednisolone is known for its immunosuppressive properties and is often used in treating various medical conditions, including some types of anemia, its specific efficacy in treating aplastic anemia would need further investigation through additional clinical studies and evidence beyond this single case report." +14742554,Prednisolone treats psoriasis,1112,Genetically determined coincidence of Kaposi sarcoma and psoriasis in an HIV-negative patient after prednisolone treatment.,True,"'Does the phrase ""Prednisolone treats psoriasis"" receive at least indirect support from the statement: ""Genetically determined coincidence of Kaposi sarcoma and psoriasis in an HIV-negative patient after prednisolone treatment.""?","Yes, indirect support can be inferred from the statement provided. The key information here is that a patient with psoriasis developed Kaposi sarcoma after being treated with prednisolone. While prednisolone is not specifically used to treat psoriasis but rather used for its anti-inflammatory effects, it has been reported in some cases to exacerbate psoriasis symptoms due to its immunosuppressive nature [1]. - To further elaborate on why there is no indirect support for prednisolone treating hypersensitivity pneumonitis based on the given statement: + The development of Kaposi sarcoma in this patient after prednisolone treatment suggests that prednisolone might have influenced disease progression in some way [2]. Although Kaposi sarcoma is not typically associated with psoriasis [3], it is known that immunosuppression can lead to Kaposi sarcoma development [4]. - - The study focuses on determining the impact of MMF and AZA on lung function and prednisolone dose in cHP patients; it does not evaluate prednisolone as a standalone treatment for hypersensitivity pneumonitis nor provide any correlation between prednisolone use and improvement in patients' conditions; + Therefore, even though prednisolone is not a direct treatment for psoriasis itself, there is indirect support for the connection between prednisolone use and psoriasis progression as suggested by the provided statement. - - The statement does not include any information about prednisolone's therapeutic benefits for cHP patients; + References: + + [1] van de Kerkhof PCM, de Rie MA," +14676056,Prednisolone treats habitual spontaneous abortion,1113,Prednisolone Trial: Study protocol for a randomised controlled trial of prednisolone for women with idiopathic recurrent miscarriage and raised levels of uterine natural killer (uNK) cells in the endometrium.,True,"'Does the phrase ""Prednisolone treats habitual spontaneous abortion"" receive at least indirect support from the statement: ""Prednisolone Trial: Study protocol for a randomised controlled trial of prednisolone for women with idiopathic recurrent miscarriage and raised levels of uterine natural killer (uNK) cells in the endometrium.""?","Yes, indirectly. The statement ""Prednisolone Trial: Study protocol for a randomised controlled trial of prednisolone for women with idiopathic recurrent miscarriage and raised levels of uterine natural killer (uNK) cells in the endometrium"" does provide some level of indirect support for the claim that ""Prednisolone treats habitual spontaneous abortion"". This is because it mentions a clinical trial investigating the use of prednisolone in treating women who have idiopathic recurrent miscarriage - which is a type of spontaneous abortion - and who have raised levels of uterine natural killer cells in their endometrium. - - The study does not compare prednisolone to other treatments for" -20836940,Prednisolone treats juvenile idiopathic arthritis,1101,"Here, we report the case of an 8-year-old girl with a 5-year history of multiple subcutaneous nodules on her extremities and a right wrist joint contracture who had been previously diagnosed with juvenile idiopathic arthritis and treated with salazosulfapyridine, low-dose prednisolone (PSL) and methotrexate.",True,"Is the triple 'Prednisolone treats juvenile idiopathic arthritis' supported by the sentence: 'Here, we report the case of an 8-year-old girl with a 5-year history of multiple subcutaneous nodules on her extremities and a right wrist joint contracture who had been previously diagnosed with juvenile idiopathic arthritis and treated with salazosulfapyridine, low-dose prednisolone (PSL) and methotrexate.'?","Yes, based on the statement provided, there is indirect support for the claim that prednisolone treats juvenile idiopathic arthritis. The patient in question was treated with low-dose prednisolone (PSL) as part of her treatment regimen for juvenile idiopathic arthritis. The fact that she was given prednisolone as part of her treatment suggests that it is used as a therapeutic agent for this condition, even if it is not specifically stated that prednisolone was responsible for any improvement in her condition. However, it is important to note that without additional information about the patient's response to treatment, we cannot definitively say that prednisolone was effective in treating her juvenile idiopathic arthritis." -20612701,Prednisolone treats myocarditis,1102,This is a case of EGPA relapse presenting as myocarditis despite treatment with prednisolone.,True,Is the triple 'Prednisolone treats myocarditis' supported by the sentence: 'This is a case of EGPA relapse presenting as myocarditis despite treatment with prednisolone.'?,"Yes, indirectly it does support that prednisolone may have some effect on myocarditis in the context of Eosinophilic Granulomatosis with Polyangiitis (EGPA). The statement ""This is a case of EGPA relapse presenting as myocarditis despite treatment with prednisolone"" implies that despite being on prednisolone therapy, the patient still experienced a relapse of myocarditis due to EGPA. This does not necessarily mean that prednisolone is ineffective for treating myocarditis in all cases; rather it suggests that in some cases (such as in EGPA relapse), prednisolone may not be sufficient on its own for treating myocarditis. + + However, it is important to note that even though there is an ongoing study examining prednisolone as a potential treatment for recurrent miscarriage in specific patient populations, it does not automatically mean that prednisolone is proven to treat all forms of spontaneous abortion in all women. The results of clinical trials must be thoroughly evaluated before drawing any definitive conclusions about their efficacy and safety in clinical practice. - To further support my interpretation: + + Additionally, it is worth noting that habitual spontaneous abortion is typically" +14345678,Prednisolone treats thrombotic thrombocytopenic purpura,1114,"The second was a 6-year-old boy with acquired relapsing TTP previously managed with plasmapheresis and prednisolone, who presented with a third relapse that was treated with plasmapheresis and rituximab; he remains in remission 17 months after treatment.",True,"'Does the phrase ""Prednisolone treats thrombotic thrombocytopenic purpura"" receive at least indirect support from the statement: ""The second was a 6-year-old boy with acquired relapsing TTP previously managed with plasmapheresis and prednisolone, who presented with a third relapse that was treated with plasmapheresis and rituximab; he remains in remission 17 months after treatment.""?","Yes, the phrase ""Prednisolone treats thrombotic thrombocytopenic purpura (TTP)"" does receive indirect support from the statement provided. - - A study published in Clinical Rheumatology in 2016 titled ""Prednisolone in Eosinophilic Granulomatosis with Polyangiitis: A Systematic Review"" showed that prednisolone is an important component in treating EGPA but also noted that it is often used in combination therapy due to its limitations in managing some aspects of" -17604301,Prednisolone treats cataract,1103,"Her visual acuity remained stable, despite development of a cataract from prednisolone therapy.",False,"Is the triple 'Prednisolone treats cataract' supported by the sentence: 'Her visual acuity remained stable, despite development of a cataract from prednisolone therapy.'?","No, the statement ""Her visual acuity remained stable, despite development of a cataract from prednisolone therapy"" does not provide direct or indirect support for the claim that ""Prednisolone treats cataract."" In fact, it suggests the opposite: that prednisolone therapy may cause cataracts (as evidenced by its development during treatment), while visual acuity remains stable due to factors other than prednisolone addressing the cataract itself. Prednisolone is a corticosteroid used primarily for its anti-inflammatory effects rather than treating cataracts directly; cataract surgery is typically required for visual improvement in cases where cataracts develop during prednisolone therapy." -17312178,Prednisolone treats type 2 diabetes mellitus,1104,"In this study, we hypothesized that concomitant administration of the dipeptidyl peptidase-4 inhibitor sitagliptin and prednisolone in men at high risk to develop type 2 diabetes could protect against the GC-induced diabetogenic effects.",False,"Is the triple 'Prednisolone treats type 2 diabetes mellitus' supported by the sentence: 'In this study, we hypothesized that concomitant administration of the dipeptidyl peptidase-4 inhibitor sitagliptin and prednisolone in men at high risk to develop type 2 diabetes could protect against the GC-induced diabetogenic effects.'?","No, the statement does not provide direct support for the claim that prednisolone treats type 2 diabetes mellitus. The study in question hypothesizes that prednisolone could protect against glucocorticoid (GC)-induced diabetogenic effects when administered concomitantly with sitagliptin in men at high risk for type 2 diabetes. This suggests that prednisolone might have a preventive or mitigative effect on diabetes development under specific circumstances rather than serving as a treatment for an established type 2 diabetes mellitus condition. + The statement describes a case of a patient with acquired relapsing TTP who was previously managed with plasmapheresis and prednisolone. The fact that prednisolone was used in the treatment regimen suggests that it has some therapeutic effect in managing TTP. However, it is important to note that prednisolone was used in conjunction with plasmapheresis, making it difficult to isolate its specific effects in this case. - The study does not demonstrate prednisolone as an independent treatment for type 2 diabetes mellitus but rather explores its potential in countering GC-induced diabetogenic effects in high-risk individuals. Therefore, it is crucial to differentiate between potential preventive properties in specific contexts from general treatment efficacy for type 2 diabetes mellitus when interpreting such evidence." -17184322,Prednisolone treats croup,1105,"Although common practice, evidence to support treatment of croup with prednisolone is scant.",False,"Is the triple 'Prednisolone treats croup' supported by the sentence: 'Although common practice, evidence to support treatment of croup with prednisolone is scant.'?","No, the statement ""Although common practice, evidence to support treatment of croup with prednisolone is scant"" does not provide indirect support for the phrase ""Prednisolone treats croup."" In fact, it suggests quite the opposite: despite widespread use (common practice), there is limited scientific evidence supporting prednisolone as an effective treatment for croup. This implies that while prednisolone might be used in treating croup, its efficacy remains uncertain and further investigation is needed to establish its therapeutic value confidently." -16852549,Prednisolone treats mature T-cell and NK-cell non-Hodgkin lymphoma,1106,"Treatment of peripheral T cell lymphoma with an intensive protocol ACEP (adriamycin, cyclophosphamide, etoposide and prednisolone) and ifosfamide showing an important response and overall survival rates.",True,"Is the triple 'Prednisolone treats mature T-cell and NK-cell non-Hodgkin lymphoma' supported by the sentence: 'Treatment of peripheral T cell lymphoma with an intensive protocol ACEP (adriamycin, cyclophosphamide, etoposide and prednisolone) and ifosfamide showing an important response and overall survival rates.'?","Yes, the statement does provide indirect support for the claim that prednisolone treats mature T-cell and NK-cell non-Hodgkin lymphoma. The statement mentions an intensive protocol ACEP (adriamycin, cyclophosphamide, etoposide and prednisolone) being used to treat peripheral T cell lymphoma (a type of non-Hodgkin lymphoma). The fact that prednisolone is included in this treatment regimen suggests that it has some therapeutic effect on these types of lymphomas. However, it is important to note that prednisolone is likely not acting alone in this treatment regimen, but rather in combination with other drugs (adriamycin, cyclophosphamide, etoposide and ifosfamide). Therefore, while there is support for prednisolone being part of an effective treatment regimen for mature T-cell and NK-cell non-Hodgkin lymphoma, it does not necessarily mean that prednisolone alone is sufficient for treatment." -16360878,Prednisolone treats ophthalmic herpes zoster,1107,"Herpes zoster ophthalmicus was suspected and treatment with i.v. acyclovir and prednisolone was commenced, which led to a gradual improvement of the clinical condition.",True,"Is the triple 'Prednisolone treats ophthalmic herpes zoster' supported by the sentence: 'Herpes zoster ophthalmicus was suspected and treatment with i.v. acyclovir and prednisolone was commenced, which led to a gradual improvement of the clinical condition.'?","Yes, the statement does provide indirect support for the phrase ""Prednisolone treats ophthalmic herpes zoster."" The patient in question was treated with both intravenous acyclovir and prednisolone for suspected herpes zoster ophthalmicus, which is a manifestation of varicella-zoster virus infection in the eye region. Following treatment initiation, there was a noted gradual improvement in their clinical condition. While correlation does not necessarily imply causation, it is plausible that prednisolone contributed positively to the observed clinical improvement given that it is an adjunctive therapy for herpes zoster ophthalmicus due to its anti-inflammatory properties. However, it is important to acknowledge that further evidence is required to establish a definitive causal relationship between prednisolone administration and clinical improvement in ophthalmic herpes zoster patients." -15441636,Prednisolone treats lipoma,1108,"Lipomas responded with less lipolysis to isoproterenol than subcutaneous fat during microdialysis, and prednisolone treatment increased lipolysis in both lipomas and subcutaneous fat.",False,"Is the triple 'Prednisolone treats lipoma' supported by the sentence: 'Lipomas responded with less lipolysis to isoproterenol than subcutaneous fat during microdialysis, and prednisolone treatment increased lipolysis in both lipomas and subcutaneous fat.'?","No, the statement does not provide direct or indirect support for the phrase ""Prednisolone treats lipoma"". The provided statement discusses how prednisolone affects lipolysis in both lipomas and subcutaneous fat during microdialysis, but it does not mention any therapeutic effect on lipomas. + Additionally, in the same patient's third relapse, rituximab was used instead of prednisolone. The patient's subsequent remission does not provide evidence against prednisolone's effectiveness in treating TTP; it merely demonstrates that other effective treatments also exist. - To further elaborate on the nuances involved in interpreting such evidence: + Therefore, while not definitive proof, the statement does provide some indirect support for prednisolone being used in the treatment of TTP based on its previous application in managing relapses of the disease in this particular patient." +14012190,Prednisolone treats angioimmunoblastic T-cell lymphoma,1115,"Three months later, AILD relapsed in spite of prednisolone treatment.",False,"'Does the phrase ""Prednisolone treats angioimmunoblastic T-cell lymphoma"" receive at least indirect support from the statement: ""Three months later, AILD relapsed in spite of prednisolone treatment.""?","No, the statement does not provide indirect support for the phrase ""Prednisolone treats angioimmunoblastic T-cell lymphoma."" In fact, it seems to suggest the opposite. The statement indicates that a patient with AILD (Autoimmune Lymphoproliferative Syndrome), who was being treated with prednisolone, experienced a relapse three months into their treatment. This implies that prednisolone may not be an effective treatment for angioimmunoblastic T-cell lymphoma (AITL), since the patient relapsed despite taking it. - - The statement describes an experimental setting using microdialysis, which is an invasive technique used for monitoring changes in concentrations of various substances in the extracellular space in vivo. This is an essential piece of information in understanding how these results were obtained but does not necessarily translate into direct therapeutic benefits in treating lipomas. + However, it is important to note that this single observation does not definitively prove that prednisolone is ineffective for treating AITL. A rigorous clinical trial would be required to make such a determination. But based on this information alone, it would not be reasonable to conclude that prednisolone treats AITL effectively." +13758030,Prednisolone treats optic neuritis,1116,Acute generalized exanthematous pustulosis induced by high-dose prednisolone in a young woman with optic neuritis owing to disseminated encephalomyelitis.,False,"'Does the phrase ""Prednisolone treats optic neuritis"" receive at least indirect support from the statement: ""Acute generalized exanthematous pustulosis induced by high-dose prednisolone in a young woman with optic neuritis owing to disseminated encephalomyelitis.""?","No, the statement does not provide indirect support for the phrase ""Prednisolone treats optic neuritis."" The statement describes a case where high-dose prednisolone was associated with acute generalized exanthematous pustulosis in a patient with optic neuritis caused by disseminated encephalomyelitis. However, it does not imply that prednisolone is an effective treatment for optic neuritis. In fact, it suggests a potential adverse effect of prednisolone use in such cases." +13566191,Prednisolone treats follicular lymphoma,1117,"The addition of rituximab to cyclophosphamide, vincristine and prednisolone (CVP) for advanced follicular lymphoma increases median time to progression by 17 months.",False,"'Does the phrase ""Prednisolone treats follicular lymphoma"" receive at least indirect support from the statement: ""The addition of rituximab to cyclophosphamide, vincristine and prednisolone (CVP) for advanced follicular lymphoma increases median time to progression by 17 months.""?","No, the statement does not provide direct or indirect support for the phrase ""Prednisolone treats follicular lymphoma."" The statement discusses the combination therapy of cyclophosphamide, vincristine, prednisolone (CVP) along with rituximab for advanced follicular lymphoma. While prednisolone is indeed part of the treatment regimen in this scenario, it does not necessarily imply that prednisolone alone is responsible for treating follicular lymphoma. In fact, it highlights that adding rituximab to CVP (which includes prednisolone) extends median time to progression by 17 months. This indicates that prednisolone is an important component of an effective treatment plan for follicular lymphoma when used in combination therapy; however, it does not provide evidence that prednisolone can treat follicular lymphoma independently." +13327146,Prednisolone treats allergic bronchopulmonary aspergillosis,1118,"Here 2 cases of allergic bronchopulmonary aspergillosis in a family (brother and sister), treated with prednisolone with complete remission are reported.",True,"'Does the phrase ""Prednisolone treats allergic bronchopulmonary aspergillosis"" receive at least indirect support from the statement: ""Here 2 cases of allergic bronchopulmonary aspergillosis in a family (brother and sister), treated with prednisolone with complete remission are reported.""?","Yes, the statement does provide indirect support for the phrase ""Prednisolone treats allergic bronchopulmonary aspergillosis"". The case report mentions that two siblings with allergic bronchopulmonary aspergillosis were treated with prednisolone and achieved complete remission. This suggests a positive correlation between prednisolone treatment and resolution of symptoms in allergic bronchopulmonary aspergillosis. However, it is important to note that correlation does not imply causation, so further studies would be needed to definitively conclude that prednisolone is an effective treatment for allergic bronchopulmonary aspergillosis. Additionally, potential side effects, contraindications, and optimal dosage of prednisolone would need to be considered in future investigations." +13311736,Prednisolone treats neoplasm,1119,FDG-PET was performed in rats bearing BCG granulomas or tumors before and after prednisolone treatment.,True,"'Does the phrase ""Prednisolone treats neoplasm"" receive at least indirect support from the statement: ""FDG-PET was performed in rats bearing BCG granulomas or tumors before and after prednisolone treatment.""?","Yes, indirectly it does support the statement that prednisolone may have some effect on neoplasm (tumors). The statement mentions that FDG-PET was performed in rats bearing BCG granulomas or tumors before and after prednisolone treatment. FDG-PET is a type of imaging that is used in part to observe the metabolic activity of cells, including cancer cells. If there was a change in the FDG-PET results after prednisolone treatment, it could suggest that prednisolone has an effect on these cells, potentially including cancer cells (neoplasm). However, it's important to note that this is an indirect inference and does not provide direct evidence that prednisolone treats neoplasm. Further studies would be needed to confirm this hypothesis." +12767794,Prednisolone treats pneumonia,1120,"After recovering from pneumonia, she was treated initially with prednisolone, 30 mg/day, and remained well until she developed hemoptysis at age 34 years.",True,"'Does the phrase ""Prednisolone treats pneumonia"" receive at least indirect support from the statement: ""After recovering from pneumonia, she was treated initially with prednisolone, 30 mg/day, and remained well until she developed hemoptysis at age 34 years.""?","Yes, while not a direct support, the statement does provide indirect evidence that prednisolone may have contributed to treating pneumonia symptoms effectively in this particular case. Prednisolone is a synthetic glucocorticoid often used in treating inflammatory conditions due to its anti-inflammatory properties. Although it is not typically considered a first-line treatment for pneumonia, it could still play an essential role in managing complications associated with pneumonia or in cases where there is an underlying inflammatory component. - - The study found that prednisolone increased lipolysis in both lipomas and subcutaneous fat; however, an increase in lipolysis does not necessarily equate to treating lipomas effectively. Lipolysis is the process by which fat cells release fatty acids into circulation, which is not always desirable as it can lead to metabolic complications if not properly regulated. + The statement indicates that after recovering from pneumonia, the patient was treated with prednisolone (30 mg/day) and remained well until developing hemoptysis at 34 years old. This sequence of events could imply that prednisolone helped manage pneumonia symptoms or prevented recurrences effectively in that individual. However, it is crucial to note that correlation does not imply causation; therefore, it would be inappropriate to conclude that prednisolone is solely responsible for treating pneumonia based on this single observation alone. - - To establish whether prednisolone can treat" -15369817,Prednisolone treats pericarditis,1109,Treatment with prednisolone improved the pericarditis and motor nerve disturbance and the treatment with intravenous immunoglobulin improved the sensory nerve disturbance.,True,Is the triple 'Prednisolone treats pericarditis' supported by the sentence: 'Treatment with prednisolone improved the pericarditis and motor nerve disturbance and the treatment with intravenous immunoglobulin improved the sensory nerve disturbance.'?,"Yes, there is indirect support for the claim that ""Prednisolone treats pericarditis"" based on the given statement. The reason being that it mentions treatment with prednisolone improved pericarditis symptoms in a patient, which suggests that prednisolone has some therapeutic effect on pericarditis. + It is essential to consider other possible explanations for recovery in conjunction with prednisolone treatment" +12190701,Prednisolone treats castration-resistant prostate carcinoma,1121,Fifteen patients 60 to 80 years old (a mean of 72 years) with hormone-refractory prostate cancer were treated with low dose prednisolone.,True,"'Does the phrase ""Prednisolone treats castration-resistant prostate carcinoma"" receive at least indirect support from the statement: ""Fifteen patients 60 to 80 years old (a mean of 72 years) with hormone-refractory prostate cancer were treated with low dose prednisolone.""?","Yes, while the statement does not explicitly claim that prednisolone treats castration-resistant prostate carcinoma (which is a type of hormone-refractory prostate cancer), it does provide evidence that prednisolone is used in treating hormone-refractory prostate cancer. Castration-resistant prostate carcinoma is a subset of hormone-refractory prostate cancer, meaning that any treatment effective for hormone-refractory prostate cancer could potentially be used for castration-resistant prostate carcinoma. However, it is important to note that the statement does not provide information on the efficacy of prednisolone in treating hormone-refractory prostate cancer, only that it has been used in treatment. Further research would be needed to determine if prednisolone is an effective treatment for castration-resistant prostate carcinoma specifically." +11988157,Prednisolone treats diffuse large B-cell lymphoma,1122,"CHOP (cyclophosphamide, doxorubicin, vincristine and prednisolone) has been the standard chemotherapy regimen used for diffuse large cell lymphomas for over 30 years.",True,"'Does the phrase ""Prednisolone treats diffuse large B-cell lymphoma"" receive at least indirect support from the statement: ""CHOP (cyclophosphamide, doxorubicin, vincristine and prednisolone) has been the standard chemotherapy regimen used for diffuse large cell lymphomas for over 30 years.""?","Yes, indirect support can be inferred from the statement provided. The claim that CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisolone) has been the standard chemotherapy regimen used for diffuse large B-cell lymphomas (DLBCL) for over 30 years implies that prednisolone is an effective component of that treatment regimen for DLBCL patients. However, it is essential to note that prednisolone does not act alone in treating DLBCL; it is part of a multi-drug regimen known as CHOP therapy. Therefore, while there is indirect support for prednisolone's efficacy in treating DLBCL as part of CHOP therapy, it would not be accurate to conclude that prednisolone alone treats DLBCL based solely on this information. Further investigation into clinical trial results, mechanistic understanding of prednisolone action in DLBCL treatment, as well as potential side effects and resistance mechanisms would be necessary for a more thorough evaluation of prednisolone’s therapeutic utility in DLBCL treatment." +11889996,Prednisolone treats mucocutaneous lymph node syndrome,1123,"Six patients with Kawasaki disease (KD) were treated with prednisolone (1 to 2 mg/kg/day) for 3 days (from days 10 to 12 after the onset of the illness) after apparently unsuccessful treatment with intravenous immunoglobulin (IVIG, 2 g/kg/dose and additional 1 g/kg/dose).",True,"'Does the phrase ""Prednisolone treats mucocutaneous lymph node syndrome"" receive at least indirect support from the statement: ""Six patients with Kawasaki disease (KD) were treated with prednisolone (1 to 2 mg/kg/day) for 3 days (from days 10 to 12 after the onset of the illness) after apparently unsuccessful treatment with intravenous immunoglobulin (IVIG, 2 g/kg/dose and additional 1 g/kg/dose).""?","Yes, the statement does provide indirect support for the phrase ""Prednisolone treats mucocutaneous lymph node syndrome,"" which is another name for Kawasaki disease (KD). The statement describes six patients with KD who were treated with prednisolone after initial treatment with intravenous immunoglobulin (IVIG) was unsuccessful. This suggests that prednisolone was used as a secondary treatment option for KD, implying that it may have some therapeutic effect on the disease. However, it's important to note that this is indirect evidence and does not definitively prove that prednisolone treats KD. A direct causal relationship would require more rigorous clinical trials and experimental evidence." +11813573,Prednisolone treats focal segmental glomerulosclerosis,1124,"RESULTS: Of 136 patients with primary FSGS and nephrotic range proteinuria, 76 (56%) were treated with prednisolone and of this group, 59% were treated with additional immunosuppression.",True,"'Does the phrase ""Prednisolone treats focal segmental glomerulosclerosis"" receive at least indirect support from the statement: ""RESULTS: Of 136 patients with primary FSGS and nephrotic range proteinuria, 76 (56%) were treated with prednisolone and of this group, 59% were treated with additional immunosuppression.""?","Yes, indirect support can be inferred from the statement provided. The excerpt mentions that 56% of patients with primary FSGS (Focal Segmental Glomerulosclerosis) were treated with prednisolone and 59% of those treated experienced additional immunosuppression therapy. This suggests that prednisolone is used as an initial treatment for FSGS patients, which implies that prednisolone may have some therapeutic benefit in treating FSGS. However, it is important to note that direct causality cannot be established based on this statement alone since it does not provide specific information about treatment outcomes (e.g., disease progression or remission rates) in patients treated solely with prednisolone. Comprehensive clinical studies designed specifically to evaluate prednisolone as a treatment for FSGS would be required for more definitive conclusions regarding its efficacy in treating this condition." +11810617,Prednisolone treats congenital adrenal hyperplasia,1125,"METHODS: Growth parameters of twelve children (8 m, 4 f) with congenital adrenal hyperplasia were retrospectively studied while on treatment with prednisolone (PR) earlier and then hydrocortisone (HC) after it became freely available in India.",True,"'Does the phrase ""Prednisolone treats congenital adrenal hyperplasia"" receive at least indirect support from the statement: ""METHODS: Growth parameters of twelve children (8 m, 4 f) with congenital adrenal hyperplasia were retrospectively studied while on treatment with prednisolone (PR) earlier and then hydrocortisone (HC) after it became freely available in India.""?","Yes, indirect support can be inferred from the statement provided. The fact that growth parameters of twelve children with congenital adrenal hyperplasia were studied while they were on treatment with prednisolone suggests that prednisolone was being used as a form of treatment for these patients. However, it does not explicitly state that prednisolone treats congenital adrenal hyperplasia. It merely implies that it is being used in the management of the condition, which is not necessarily the same as treating the condition itself. Furthermore, the study also mentions that after prednisolone became freely available in India, these children were treated with hydrocortisone instead. This could imply that prednisolone is not as effective as hydrocortisone in treating congenital adrenal hyperplasia, but again, this is an indirect inference based on limited information. Therefore, while there is some indirect support for the claim that prednisolone treats congenital adrenal hyperplasia based on this statement, it is not direct or definitive evidence." +11808057,Prednisolone treats keratitis,1126,Ciprofloxacin and prednisolone therapy for experimental Pseudomonas keratitis.,True,"'Does the phrase ""Prednisolone treats keratitis"" receive at least indirect support from the statement: ""Ciprofloxacin and prednisolone therapy for experimental Pseudomonas keratitis.""?","Yes, the statement ""Ciprofloxacin and prednisolone therapy for experimental Pseudomonas keratitis"" does lend indirect support to the claim that prednisolone treats keratitis (corneal inflammation). The use of prednisolone in combination therapy for experimental Pseudomonas keratitis implies that prednisolone has some efficacy in treating keratitis in that context. However, it should be noted that prednisolone is often used as an anti-inflammatory agent rather than an antibacterial agent for treating keratitis; therefore, its effectiveness is generally observed in combination therapy with antibiotics like ciprofloxacin. - However, it is important to note that while there is some evidence pointing towards prednisolone being beneficial for pericarditis treatment, it is still an indirect association since other factors could have contributed to the improvement as well. Further investigation would be necessary to establish a direct cause-and-effect relationship between prednisolone use and pericarditis treatment. + In summary, while the statement does not directly demonstrate that prednisolone alone treats keratitis, it does provide evidence that prednisolone has been used in therapies for treating keratitis caused by Pseudomonas infections. The nuance here is that prednisolone is often used as an adjunct therapy to antibiotics for treating keratitis rather than as monotherapy due to its anti-inflammatory properties." +11527350,"Prednisolone treats dermatitis, atopic",1127,"Prednicarbate is a non-halogenated, double-ester derivative of prednisolone that has become of interest for the treatment of inflammatory skin diseases, for example atopic dermatitis.",True,"'Does the phrase ""Prednisolone treats dermatitis, atopic"" receive at least indirect support from the statement: ""Prednicarbate is a non-halogenated, double-ester derivative of prednisolone that has become of interest for the treatment of inflammatory skin diseases, for example atopic dermatitis.""?","Yes, there is indirect support for the claim that prednisolone treats dermatitis, atopic in the provided statement. This support arises from the fact that prednicarbate is derived from prednisolone and is used for treating inflammatory skin diseases such as atopic dermatitis. Prednisolone is a glucocorticoid steroid that is commonly used for its anti-inflammatory properties in treating various skin conditions including atopic dermatitis. Therefore, it is reasonable to infer that since prednicarbate is derived from prednisolone, it shares similar therapeutic properties for treating atopic dermatitis. However, it is important to note that while prednisolone is used topically as well as systemically for treating atopic dermatitis, prednicarbate is primarily used topically due to its lower systemic absorption rate compared to prednisolone." +11526277,Prednisolone treats kidney disorder,1128,"AIM: To evaluate the efficacy of prednisolone, warfarin, and dipyridamole therapy combined with mizoribine (PWDM) in the treatment of diffuse immunoglobulin A (IgA) nephropathy in comparison with prednisolone, warfarin, and dipyridamole therapy without mizoribine (PWD) and with methylprednisolone pulse therapy (PWD pulse).",True,"'Does the phrase ""Prednisolone treats kidney disorder"" receive at least indirect support from the statement: ""AIM: To evaluate the efficacy of prednisolone, warfarin, and dipyridamole therapy combined with mizoribine (PWDM) in the treatment of diffuse immunoglobulin A (IgA) nephropathy in comparison with prednisolone, warfarin, and dipyridamole therapy without mizoribine (PWD) and with methylprednisolone pulse therapy (PWD pulse).""?","Yes, the statement does provide indirect support for the claim that prednisolone treats kidney disorder. The study aims to evaluate the efficacy of prednisolone in treating diffuse immunoglobulin A (IgA) nephropathy, which is a kidney disorder. The fact that a study is being conducted to evaluate its efficacy suggests that there is some basis for believing that prednisolone could have a positive effect on kidney disorder treatment. However, it should be noted that this is an indirect inference, as the statement does not explicitly confirm that prednisolone treats kidney disorder, but rather that it is being studied for its potential efficacy in treating IgA nephropathy, a specific type of kidney disorder." +11497678,Prednisolone treats infertility disorder,1129,"In this double blind cross-over study, 20 infertile men, who had sperm antibodies detected by the mixed antiglobulin reaction (MAR test) in the ejaculate and by the tray agglutination test (TAT) in serum, were treated with 40 mg/day prednisolone or placebo from days 1 to 10 of the partners' menstrual cycle.",True,"'Does the phrase ""Prednisolone treats infertility disorder"" receive at least indirect support from the statement: ""In this double blind cross-over study, 20 infertile men, who had sperm antibodies detected by the mixed antiglobulin reaction (MAR test) in the ejaculate and by the tray agglutination test (TAT) in serum, were treated with 40 mg/day prednisolone or placebo from days 1 to 10 of the partners' menstrual cycle.""?","Yes, while the statement does not explicitly claim that prednisolone treats infertility disorders, it does provide indirect support for such a claim. The study mentioned is investigating the effect of prednisolone on infertile men who have sperm antibodies detected by specific tests (MAR test in ejaculate and TAT in serum). This suggests that prednisolone may have an impact on infertility disorders related to sperm antibodies, which is a step towards treating infertility disorders. However, it is important to note that more extensive studies would be needed to confirm this claim, as this particular study only involves 20 participants in a double-blind cross-over design, which may not be representative of the broader population of infertile men." +11373326,Prednisolone treats prostate cancer,1130,BACKGROUND: We conducted this retrospective study to analyze a modified dose schedule of mitoxantrone and prednisolone (MP) in patients with androgen-independent prostate cancer.,False,"'Does the phrase ""Prednisolone treats prostate cancer"" receive at least indirect support from the statement: ""BACKGROUND: We conducted this retrospective study to analyze a modified dose schedule of mitoxantrone and prednisolone (MP) in patients with androgen-independent prostate cancer.""?","No, the statement does not provide indirect support for the claim that ""Prednisolone treats prostate cancer."" The provided background statement is about a retrospective study analyzing a modified dose schedule of mitoxantrone and prednisolone (MP) in patients with androgen-independent prostate cancer. However, it does not specify that prednisolone has any therapeutic effect on prostate cancer; it only mentions its use in combination with mitoxantrone in a particular dose schedule for patients with androgen-independent prostate cancer. - In addition, it should be emphasized that medical treatments should be administered under professional supervision after considering potential side effects and interactions with other conditions or medications. A thorough evaluation of each individual case is essential before making treatment decisions." -15104714,Prednisolone treats pulmonary eosinophilia,1110,"Airway macrophage median percentage of red-hued area in stained sputum cytospin preparations was assessed by means of image analysis from (1) subjects with mild-to-severe asthma, subjects with nonasthmatic eosinophilic bronchitis, and healthy control subjects; (2) subjects with eosinophilic severe asthma after treatment with prednisolone; and (3) subject with noneosinophilic asthma before corticosteroid withdrawal.",False,"Is the triple 'Prednisolone treats pulmonary eosinophilia' supported by the sentence: 'Airway macrophage median percentage of red-hued area in stained sputum cytospin preparations was assessed by means of image analysis from (1) subjects with mild-to-severe asthma, subjects with nonasthmatic eosinophilic bronchitis, and healthy control subjects; (2) subjects with eosinophilic severe asthma after treatment with prednisolone; and (3) subject with noneosinophilic asthma before corticosteroid withdrawal.'?","No, the statement does not provide direct support for the claim that Prednisolone treats pulmonary eosinophilia. The statement describes an image analysis study involving subjects with different conditions such as asthma, nonasthmatic eosinophilic bronchitis, and healthy controls; as well as subjects with eosinophilic severe asthma after treatment with Prednisolone and subjects with noneosinophilic asthma before corticosteroid withdrawal. However, it does not explicitly provide information on how Prednisolone affects eosinophilia in pulmonary tissue before and after treatment in these subjects. + To provide indirect support for the claim that ""Prednisolone treats prostate cancer,"" one would need evidence indicating that prednisolone has an impact on prostate cancer independently of other treatments like mitoxantrone. In other words, there should be some demonstration that prednisolone has anticancer properties specific to prostate cancer cells. The background statement given does not provide such evidence; thus, it does not support the claim that prednisolone treats prostate cancer." +11166363,Prednisolone treats canker sore,1131,"It has also been used in combination with other drugs for treating a number of dermatologic disorders, e.g. in combination with cimetidine for treating recalcitrant warts, with prednisolone for treating lichen planus, erythema multiforme and aphthous ulcers of the mouth.",True,"'Does the phrase ""Prednisolone treats canker sore"" receive at least indirect support from the statement: ""It has also been used in combination with other drugs for treating a number of dermatologic disorders, e.g. in combination with cimetidine for treating recalcitrant warts, with prednisolone for treating lichen planus, erythema multiforme and aphthous ulcers of the mouth.""?","Yes, the phrase ""Prednisolone treats canker sore"" does receive indirect support from the statement provided. The statement mentions that prednisolone has been used in combination with other drugs for treating erythema multiforme and aphthous ulcers of the mouth. Aphthous ulcers of the mouth are commonly known as canker sores. Therefore, it can be inferred that prednisolone has been used in treating canker sores, albeit in combination with other drugs. However, it is important to note that this does not directly prove that prednisolone alone is effective in treating canker sores. Further research would be needed to establish this conclusively." +11166362,Prednisolone treats lichen planus,1132,"It has also been used in combination with other drugs for treating a number of dermatologic disorders, e.g. in combination with cimetidine for treating recalcitrant warts, with prednisolone for treating lichen planus, erythema multiforme and aphthous ulcers of the mouth.",True,"'Does the phrase ""Prednisolone treats lichen planus"" receive at least indirect support from the statement: ""It has also been used in combination with other drugs for treating a number of dermatologic disorders, e.g. in combination with cimetidine for treating recalcitrant warts, with prednisolone for treating lichen planus, erythema multiforme and aphthous ulcers of the mouth.""?","Yes, the phrase ""Prednisolone treats lichen planus"" does receive indirect support from the statement provided. The statement mentions that prednisolone is used in combination with other drugs for treating several dermatologic disorders, including lichen planus. This implies that prednisolone has some therapeutic effect on lichen planus, even if it is not used alone in its treatment. However, it is important to note that this is an indirect inference based on a single statement, and further evidence would be needed for a more definitive conclusion." +11166361,Prednisolone treats erythema multiforme,1133,"It has also been used in combination with other drugs for treating a number of dermatologic disorders, e.g. in combination with cimetidine for treating recalcitrant warts, with prednisolone for treating lichen planus, erythema multiforme and aphthous ulcers of the mouth.",True,"'Does the phrase ""Prednisolone treats erythema multiforme"" receive at least indirect support from the statement: ""It has also been used in combination with other drugs for treating a number of dermatologic disorders, e.g. in combination with cimetidine for treating recalcitrant warts, with prednisolone for treating lichen planus, erythema multiforme and aphthous ulcers of the mouth.""?","Yes, the phrase ""Prednisolone treats erythema multiforme"" does receive indirect support from the statement provided. - + The statement mentions that prednisolone has been used in combination with other drugs for treating a number of dermatologic disorders, including erythema multiforme. This suggests that prednisolone has some therapeutic effect on erythema multiforme, even if it is not used as a standalone treatment. - To provide indirect support for the claim that Prednisolone treats pulmonary eosinophilia, there should be some comparison made between eosinophil levels in pulmonary tissue before treatment with Prednisolone and after treatment in these subjects. The statement does not provide any direct evidence for such comparison; thus, it does not offer substantial support for the claim that Prednisolone treats pulmonary eosinophilia based on this information alone." -14992803,Prednisolone treats aplastic anemia,1111,"We report a case of subcutaneous abscess caused by Nocardia farcinica in a 44-year-old man, who had been treated with systemic prednisolone and cyclosporin for aplastic anemia.",True,"Is the triple 'Prednisolone treats aplastic anemia' supported by the sentence: 'We report a case of subcutaneous abscess caused by Nocardia farcinica in a 44-year-old man, who had been treated with systemic prednisolone and cyclosporin for aplastic anemia.'?","Yes, there is indirect support for the claim that prednisolone treats aplastic anemia based on the given statement. The individual in question was being treated for aplastic anemia using prednisolone as part of their therapeutic regimen. The fact that they were receiving treatment for aplastic anemia suggests that prednisolone is used in managing this condition. However, it should be noted that association does not necessarily imply causation; other factors could also be influencing the treatment outcomes for aplastic anemia. Additionally, it is important to consider that prednisolone may be used in combination therapy for treating aplastic anemia in certain cases, as seen here where cyclosporin is also used alongside prednisolone." -14742554,Prednisolone treats psoriasis,1112,Genetically determined coincidence of Kaposi sarcoma and psoriasis in an HIV-negative patient after prednisolone treatment.,True,Is the triple 'Prednisolone treats psoriasis' supported by the sentence: 'Genetically determined coincidence of Kaposi sarcoma and psoriasis in an HIV-negative patient after prednisolone treatment.'?,"Yes, indirectly it does lend some support to the claim that prednisolone might be used in treating psoriasis, although it doesn't establish a direct causal relationship between prednisolone treatment and improvement in psoriasis symptoms in this particular case. + However, it's important to note that the statement does not provide direct evidence of prednisolone's efficacy in treating erythema multiforme in isolation. The treatment could be synergistic with other drugs, meaning that prednisolone may not be effective on its own for treating erythema multiforme. - Here's why: + Therefore, while there is some support for the claim, it is indirect and should be interpreted with caution. Further research would be needed to establish whether prednisolone is an effective monotherapy for erythema multiforme." +10782301,Prednisolone treats adrenocortical insufficiency,1134,Prednisolone in the treatment of adrenal insufficiency: a re-evaluation of relative potency.,True,"'Does the phrase ""Prednisolone treats adrenocortical insufficiency"" receive at least indirect support from the statement: ""Prednisolone in the treatment of adrenal insufficiency: a re-evaluation of relative potency.""?","Yes, the statement ""Prednisolone in the treatment of adrenal insufficiency: a re-evaluation of relative potency"" does provide indirect support for the claim that ""Prednisolone treats adrenocortical insufficiency."" The title of the study suggests that it is investigating the use of Prednisolone in treating adrenal insufficiency, which is another term for adrenocortical insufficiency. Therefore, this study is likely looking at how Prednisolone can be used to manage or treat adrenocortical insufficiency. However, it is important to note that indirect support does not equate to definitive proof. To fully evaluate the validity of the claim, it would be necessary to review the methods, results, and conclusions of the study in detail." +10757066,Prednisolone treats atopic eczema,1135,[Results of prednisolone therapy of eczemas in very young and older infants].,True,"'Does the phrase ""Prednisolone treats atopic eczema"" receive at least indirect support from the statement: ""[Results of prednisolone therapy of eczemas in very young and older infants].""?","Yes, the phrase ""Prednisolone treats atopic eczema"" does receive indirect support from the statement ""[Results of prednisolone therapy of eczemas in very young and older infants]."" This is because the statement suggests that prednisolone has been used in therapy for eczemas in both young and older infants, implying that it may have some effect on treating eczema. However, it is important to note that this is indirect support and does not provide direct evidence of prednisolone's effectiveness in treating atopic eczema. Further research and evidence would be needed to make a definitive conclusion." +10671990,Prednisolone treats Headache,1136,"We report a patient with neuro-Behcet's syndrome presenting with headache and personality change in whom CT and MRI brain imaging was normal, but regional cerebral blood flow imaging using single photon emission tomography with the tracer HMPAO showed extensive perfusion deficits which partially reversed after 3 months of prednisolone therapy.",True,"'Does the phrase ""Prednisolone treats Headache"" receive at least indirect support from the statement: ""We report a patient with neuro-Behcet's syndrome presenting with headache and personality change in whom CT and MRI brain imaging was normal, but regional cerebral blood flow imaging using single photon emission tomography with the tracer HMPAO showed extensive perfusion deficits which partially reversed after 3 months of prednisolone therapy.""?","Yes, the statement does provide indirect support for the claim that prednisolone treats headache. The patient in question was diagnosed with neuro-Behcet's syndrome and was experiencing headaches along with other symptoms. After a treatment period of three months with prednisolone therapy, there was a partial reversal of extensive perfusion deficits in regional cerebral blood flow imaging. Although the statement does not explicitly say that prednisolone treats headaches, it suggests that the drug has had a positive impact on the patient's neurological status, which could reasonably include headache relief given that headaches were part of the patient's initial presentation. However, it is important to note that this is an indirect inference based on one case report; further evidence from controlled clinical trials would be needed to confirm that prednisolone is an effective treatment for headaches associated with neuro-Behcet's syndrome." +10574410,Prednisolone treats synovitis,1137,Prednisolone (meticortelone) in treatment of epicondylitis; radiohumeral bursitis and radiohumeral synovitis.,True,"'Does the phrase ""Prednisolone treats synovitis"" receive at least indirect support from the statement: ""Prednisolone (meticortelone) in treatment of epicondylitis; radiohumeral bursitis and radiohumeral synovitis.""?","Yes, the phrase ""Prednisolone treats synovitis"" does receive indirect support from the statement ""Prednisolone (meticortelone) in treatment of epicondylitis; radiohumeral bursitis and radiohumeral synovitis."" This is because synovitis is specifically mentioned as one of the conditions treated by Prednisolone in the given statement. - The statement mentions that an HIV-negative patient who had both Kaposi sarcoma (KS) and psoriasis experienced these conditions coincidentally after receiving prednisolone treatment. Prednisolone is a synthetic glucocorticoid often used as an anti-inflammatory medication for various conditions including dermatological disorders like psoriasis. + However, it is important to note that Prednisolone is mentioned in conjunction with Meticortelone in the original statement. Meticortelone is a different glucocorticoid steroid used in anti-inflammatory therapy, similar to Prednisolone. While it is reasonable to infer that Prednisolone can treat synovitis based on this statement, it would be more accurate to attribute this effect specifically to Prednisolone if it were mentioned alone in a treatment context for synovitis. - While KS is not typically associated with psoriasis, both conditions can involve inflammation. Therefore, it is plausible that prednisolone was prescribed primarily for its anti-inflammatory properties rather than specifically for treating psoriasis in this case. + Additionally, while synovitis is mentioned in relation to radiohumeral synovitis in the original statement, it is possible that Prednisolone may be more effective at treating certain types of synovitis than others due to differences in underlying pathophysiology." +10574409,Prednisolone treats epicondylitis,1138,Prednisolone (meticortelone) in treatment of epicondylitis; radiohumeral bursitis and radiohumeral synovitis.,True,"'Does the phrase ""Prednisolone treats epicondylitis"" receive at least indirect support from the statement: ""Prednisolone (meticortelone) in treatment of epicondylitis; radiohumeral bursitis and radiohumeral synovitis.""?","Yes, there is indirect support for the claim that prednisolone treats epicondylitis based on the provided statement. The statement mentions prednisolone (meticortelone) in the treatment of epicondylitis, radiohumeral bursitis, and radiohumeral synovitis. This implies that prednisolone could be an effective treatment for epicondylitis, even though it does not explicitly state that prednisolone is used solely for epicondylitis treatment. However, it is important to note that meticortelone is not exactly the same as prednisolone but is instead a prodrug of prednisolone. Therefore, while there is some level of support for prednisolone as an effective treatment for epicondylitis based on this statement, further investigation is necessary for more definitive conclusions." +10565149,Prednisolone treats osteoarthritis,1139,"Intra-articular injections of hydrocortisone prednisolone, and their tertiary-butylacetate derivatives in patients with rheumatoid arthritis and osteoarthritis.",True,"'Does the phrase ""Prednisolone treats osteoarthritis"" receive at least indirect support from the statement: ""Intra-articular injections of hydrocortisone prednisolone, and their tertiary-butylacetate derivatives in patients with rheumatoid arthritis and osteoarthritis.""?","Yes, there is indirect support for the claim that prednisolone treats osteoarthritis based on the provided statement. The statement mentions that intra-articular injections of hydrocortisone prednisolone have been used in patients with rheumatoid arthritis and osteoarthritis. Prednisolone is a glucocorticoid that has anti-inflammatory effects, which is one of its mechanisms of action in treating various conditions including arthritis. - However, since psoriasis is one of the conditions for which prednisolone is often prescribed, its mention in this context implies that prednisolone could have had an impact on p" -14676056,Prednisolone treats habitual spontaneous abortion,1113,Prednisolone Trial: Study protocol for a randomised controlled trial of prednisolone for women with idiopathic recurrent miscarriage and raised levels of uterine natural killer (uNK) cells in the endometrium.,True,Is the triple 'Prednisolone treats habitual spontaneous abortion' supported by the sentence: 'Prednisolone Trial: Study protocol for a randomised controlled trial of prednisolone for women with idiopathic recurrent miscarriage and raised levels of uterine natural killer (uNK) cells in the endometrium.'?,"Yes, indirectly. The statement describes a randomized controlled trial protocol for prednisolone in women with idiopathic recurrent miscarriage who have raised levels of uterine natural killer (uNK) cells in the endometrium. This implies that there is an interest in exploring prednisolone as a potential treatment for recurrent miscarriage in specific circumstances (raised uNK cells). However, it does not provide direct support for the claim that prednisolone treats habitual spontaneous abortion since the study results have not been presented yet. Therefore, any conclusion drawn from this statement should be considered preliminary and subject to further investigation." -14345678,Prednisolone treats thrombotic thrombocytopenic purpura,1114,"The second was a 6-year-old boy with acquired relapsing TTP previously managed with plasmapheresis and prednisolone, who presented with a third relapse that was treated with plasmapheresis and rituximab; he remains in remission 17 months after treatment.",True,"Is the triple 'Prednisolone treats thrombotic thrombocytopenic purpura' supported by the sentence: 'The second was a 6-year-old boy with acquired relapsing TTP previously managed with plasmapheresis and prednisolone, who presented with a third relapse that was treated with plasmapheresis and rituximab; he remains in remission 17 months after treatment.'?","Yes, the statement does provide indirect support for the phrase ""Prednisolone treats thrombotic thrombocytopenic purpura (TTP)"". The case describes a patient who had previously been managed with prednisolone during relapses of TTP, suggesting that prednisolone was an effective treatment in those instances. However, it is important to note that the patient was also treated with plasmapheresis during all relapses, making it impossible to determine whether prednisolone or plasmapheresis (or both) were responsible for managing TTP in this case. Additionally, in the most recent relapse, rituximab was used alongside plasmapheresis instead of prednisolone, which could imply that rituximab has become the preferred treatment for TTP over prednisolone in certain cases. Therefore, while there is some support for prednisolone as a treatment for TTP based on this statement, it is not unequivocal evidence due to confounding factors such as concurrent treatments and limited scope in one patient case." -14012190,Prednisolone treats angioimmunoblastic T-cell lymphoma,1115,"Three months later, AILD relapsed in spite of prednisolone treatment.",False,"Is the triple 'Prednisolone treats angioimmunoblastic T-cell lymphoma' supported by the sentence: 'Three months later, AILD relapsed in spite of prednisolone treatment.'?","No, the statement ""Three months later, AILD relapsed in spite of prednisolone treatment"" does not provide indirect support for the claim that ""Prednisolone treats angioimmunoblastic T-cell lymphoma"" (AILD). + However, it is important to note that prednisolone is not typically considered as a first-line treatment for osteoarthritis due to its potential side effects when used systemically over long periods of time (e.g., osteoporosis, diabetes mellitus). It is more commonly used in rheumatoid arthritis which is an autoimmune disorder characterized by inflammation in multiple joints. Intra-articular injections of glucocorticoids like prednisolone may be used in osteoarthritis for short-term pain relief in specific cases (e.g., severe pain flare-" +10557390,Prednisolone treats peptic ulcer disease,1140,On the development of peptic ulcers in patients treated with prednisone or prednisolone.,False,"'Does the phrase ""Prednisolone treats peptic ulcer disease"" receive at least indirect support from the statement: ""On the development of peptic ulcers in patients treated with prednisone or prednisolone.""?","No, the statement does not provide indirect support for the phrase ""Prednisolone treats peptic ulcer disease"". The original statement discusses the development of peptic ulcers in patients treated with prednisone or prednisolone, which implies that these drugs may be associated with an increased risk of developing peptic ulcers, not that they treat the condition. Therefore, based on this information alone, there is no evidence or indirect support suggesting that prednisolone is used as a treatment for peptic ulcer disease. - In fact, it suggests the opposite: that prednisolone may not be effective in treating AILD. The term ""relapsed"" indicates that the patient's condition worsened despite receiving prednisolone treatment for three months, which implies that prednisolone did not successfully manage AILD in this case. + To further clarify, prednisolone is a synthetic glucocorticoid used primarily for its anti-inflammatory effects in various medical conditions (1). Prolonged use of glucocorticoids like prednisolone has been associated with an increased risk of developing gastrointestinal side effects such as peptic ulcers (2). Therefore, it is essential to consider alternative sources and additional evidence when making conclusions about therapeutic uses of medications like prednisolone in peptic ulcer disease treatment. - However, it is important to note that one case does not establish definitive evidence about a treatment's efficacy due to individual variability in response to treatments and numerous other factors that may affect patient outcomes. Further studies involving larger sample sizes would be required for stronger conclusions about prednisolone's effectiveness in treating AILD." -13758030,Prednisolone treats optic neuritis,1116,Acute generalized exanthematous pustulosis induced by high-dose prednisolone in a young woman with optic neuritis owing to disseminated encephalomyelitis.,True,Is the triple 'Prednisolone treats optic neuritis' supported by the sentence: 'Acute generalized exanthematous pustulosis induced by high-dose prednisolone in a young woman with optic neuritis owing to disseminated encephalomyelitis.'?,"Yes, indirectly it does support that prednisolone treats optic neuritis. The statement mentions that the patient had optic neuritis caused by disseminated encephalomyelitis and was treated with high-dose prednisolone, which induced acute generalized exanthematous pustulosis (AGEP). While AGEP is an adverse effect indicating high-dose prednisolone might not be ideal for everyone, it does not negate its therapeutic effect on optic neuritis in this case. Therefore, one could infer that prednisolone has been used successfully in treating optic neuritis in at least some instances. However, it is essential to acknowledge that this does not establish causality nor does it confirm prednisolone as first-line treatment for optic neuritis without further supporting evidence from clinical trials and large-scale studies that demonstrate its safety and efficacy for treating optic neuritis specifically." -13566191,Prednisolone treats follicular lymphoma,1117,"The addition of rituximab to cyclophosphamide, vincristine and prednisolone (CVP) for advanced follicular lymphoma increases median time to progression by 17 months.",False,"Is the triple 'Prednisolone treats follicular lymphoma' supported by the sentence: 'The addition of rituximab to cyclophosphamide, vincristine and prednisolone (CVP) for advanced follicular lymphoma increases median time to progression by 17 months.'?","No, the statement does not provide direct support for the claim that prednisolone treats follicular lymphoma. The statement only indicates that adding rituximab to cyclophosphamide, vincristine, and prednisolone (CVP) increases median time to progression in advanced follicular lymphoma by 17 months compared to CVP alone. This does not necessarily indicate that prednisolone has any therapeutic effect on follicular lymphoma specifically because it is given in combination therapy (CVP) in the study mentioned. To establish that prednisolone treats follicular lymphoma, there should be evidence showing its efficacy when administered alone in treating follicular lymphoma patients." -13327146,Prednisolone treats allergic bronchopulmonary aspergillosis,1118,"Here 2 cases of allergic bronchopulmonary aspergillosis in a family (brother and sister), treated with prednisolone with complete remission are reported.",True,"Is the triple 'Prednisolone treats allergic bronchopulmonary aspergillosis' supported by the sentence: 'Here 2 cases of allergic bronchopulmonary aspergillosis in a family (brother and sister), treated with prednisolone with complete remission are reported.'?","Yes, the statement does provide indirect support for the claim that prednisolone treats allergic bronchopulmonary aspergillosis (ABPA). The provided statement reports two cases of ABPA in siblings who were treated with prednisolone and achieved complete remission. However, it is important to note that while this suggests an association between prednisolone treatment and remission in these individuals, it does not definitively prove causation nor generalizability beyond these specific cases. + References: + + 1. Fardet L, Delarue J, Oberto G, et al. Effect of" +10513879,Prednisolone treats celiac disease,1141,The simultaneous correction of plain-water deficit and extracellular fluid volume loss in non-tropical sprue treated with prednisolone.,False,"'Does the phrase ""Prednisolone treats celiac disease"" receive at least indirect support from the statement: ""The simultaneous correction of plain-water deficit and extracellular fluid volume loss in non-tropical sprue treated with prednisolone.""?","No, the statement does not provide indirect support for the claim that prednisolone treats celiac disease. - The evidence provided is observational in nature, meaning that it does not control for potential confounding factors that could also influence remission in ABPA patients. For instance, other treatments, lifestyle factors, or genetic predispositions may have contributed to their recovery alongside prednisolone usage. To establish stronger evidence for prednisolone as an effective treatment for ABPA, further studies such as randomized controlled trials would be necessary. + The statement ""The simultaneous correction of plain-water deficit and extracellular fluid volume loss in non-tropical sprue treated with prednisolone"" refers specifically to the management of symptoms associated with non-tropical sprue (a historical term often used interchangeably with celiac disease) such as dehydration and fluid loss. It does not imply that prednisolone is treating or curing the underlying disease itself but rather alleviates some of its secondary symptoms. Prednisolone is a corticosteroid often used in treating inflammatory conditions; its use in celiac disease is typically aimed at managing severe symptoms of refractory celiac disease rather than as a primary treatment for celiac disease itself." +10509017,Prednisolone treats hepatocellular carcinoma,1142,"One had received four weekly cycles of prednisolone, Adriamycin, vincristine and 5-fluorouracil for an inoperable HCC with a 10-cm diameter, and the other had received localised synchronised hepatic irradiation and Adriamycin.",False,"'Does the phrase ""Prednisolone treats hepatocellular carcinoma"" receive at least indirect support from the statement: ""One had received four weekly cycles of prednisolone, Adriamycin, vincristine and 5-fluorouracil for an inoperable HCC with a 10-cm diameter, and the other had received localised synchronised hepatic irradiation and Adriamycin.""?","No, the statement does not provide indirect support for the claim that prednisolone treats hepatocellular carcinoma (HCC). The statement only mentions that one patient had received prednisolone as part of a treatment regimen for an inoperable HCC, but it does not provide any information about the outcome of that treatment specifically related to prednisolone. Therefore, it is not possible to infer any causal relationship between prednisolone and treatment of HCC from this statement alone." +10502737,Prednisolone treats hemolytic anemia,1143,"[A case of hemolytic anemia with generalized agglutination, treated with ACTH, cortisone, and prednisolone].",True,"'Does the phrase ""Prednisolone treats hemolytic anemia"" receive at least indirect support from the statement: ""[A case of hemolytic anemia with generalized agglutination, treated with ACTH, cortisone, and prednisolone].""?","Yes, indirect support can be inferred from the statement provided. The case description mentions that prednisolone was one of the treatments administered for hemolytic anemia alongside ACTH and cortisone. However, it does not explicitly state that prednisolone was responsible for treating the hemolytic anemia. Therefore, while not definitive proof, it does provide some level of indirect support for the claim that prednisolone can be used to treat hemolytic anemia based on clinical practice in this particular case. It is important to note that further investigation and evidence would be required for more conclusive backing of such a claim in broader clinical contexts." +10335998,Prednisolone treats pemphigus,1144,"OBJECTIVES: The present study describes our experience of the addition of mycophenolate mofetil (MMF) to prednisolone in the management of severe, refractory pemphigus.",True,"'Does the phrase ""Prednisolone treats pemphigus"" receive at least indirect support from the statement: ""OBJECTIVES: The present study describes our experience of the addition of mycophenolate mofetil (MMF) to prednisolone in the management of severe, refractory pemphigus.""?","Yes, indirectly it does lend support. The statement indicates that prednisolone is used in combination with mycophenolate mofetil (MMF) for managing severe, refractory pemphigus. This implies that prednisolone is being utilized as part of the treatment regimen for pemphigus patients in this study. However, it does not provide direct evidence that prednisolone alone treats pemphigus effectively; it only suggests its use as part of a larger treatment plan when combined with MMF." +10020250,Prednisolone treats Hodgkins lymphoma,1145,"Under the diagnosis of Hodgkin's disease, she was treated with combination chemotherapy containing pirarubicin, cyclophosphamide, vincristine, and prednisolone.",True,"'Does the phrase ""Prednisolone treats Hodgkins lymphoma"" receive at least indirect support from the statement: ""Under the diagnosis of Hodgkin's disease, she was treated with combination chemotherapy containing pirarubicin, cyclophosphamide, vincristine, and prednisolone.""?","Yes, there is indirect support for the statement that ""Prednisolone treats Hodgkin's lymphoma"" in the provided context. The statement ""Under the diagnosis of Hodgkin's disease, she was treated with combination chemotherapy containing pirarubicin, cyclophosphamide, vincristine, and prednisolone"" indicates that prednisolone was one of the drugs used in the treatment regimen for a patient diagnosed with Hodgkin's disease (also known as Hodgkin lymphoma). - Nonetheless, given that prednisolone is an immunosuppressive drug commonly used for treating inflammatory conditions, it is plausible that it could help manage ABPA symptoms by reducing inflammation in response to Aspergillus antigens in suscept" -13311736,Prednisolone treats neoplasm,1119,FDG-PET was performed in rats bearing BCG granulomas or tumors before and after prednisolone treatment.,False,Is the triple 'Prednisolone treats neoplasm' supported by the sentence: 'FDG-PET was performed in rats bearing BCG granulomas or tumors before and after prednisolone treatment.'?,"No, the statement does not provide direct or indirect support for the claim that Prednisolone treats neoplasm (tumors). The study mentioned in the statement involves FDG-PET scans being performed on rats bearing BCG granulomas or tumors before and after prednisolone treatment. However, it does not provide any information about the effects of prednisolone treatment on tumor growth, progression, or regression. Therefore, it does not support the assertion that prednisolone can be used as a treatment for neoplasm. + The use of prednisolone in this context suggests that it has therapeutic value in treating Hodgkin lymphoma, even if it is not used as a single-agent treatment. Prednisolone is often used in combination chemotherapy regimens due to its immunosuppressive properties and its ability to enhance the cytotoxicity of certain chemotherapeutic agents. Therefore, while prednisolone may not be solely responsible for treating Hodgkin lymphoma in all cases, its inclusion in a treatment regimen for Hodgkin lymphoma provides indirect evidence for its potential ther" +9848677,Prednisolone treats Inflammation,1146,"Patients who remain high transporters with inflammatory reaction might require pharmacologic intervention, including prednisolone therapy.",True,"'Does the phrase ""Prednisolone treats Inflammation"" receive at least indirect support from the statement: ""Patients who remain high transporters with inflammatory reaction might require pharmacologic intervention, including prednisolone therapy.""?","Yes, the phrase ""Prednisolone treats Inflammation"" does receive indirect support from the statement provided. The statement suggests that prednisolone therapy may be necessary for patients who have an inflammatory reaction and remain high transporters. This implies that prednisolone has an anti-inflammatory effect, which aligns with the phrase ""Prednisolone treats Inflammation"". However, it's important to note that this is an indirect inference based on the statement's mention of prednisolone as a potential treatment for inflammatory conditions. For a more direct support, a statement explicitly stating that prednisolone treats inflammation would be needed." +9729887,Prednisolone treats glomerulonephritis,1147,"[Comparative characteristics of the spectrum of free amino acids of blood serum and urine in children with glomerulonephritis treated with prednisolone, leukeran and anabolic steroids].",True,"'Does the phrase ""Prednisolone treats glomerulonephritis"" receive at least indirect support from the statement: ""[Comparative characteristics of the spectrum of free amino acids of blood serum and urine in children with glomerulonephritis treated with prednisolone, leukeran and anabolic steroids].""?","Yes, the statement does provide indirect support for the claim that Prednisolone treats glomerulonephritis. The title of the paper suggests a comparative study of free amino acids in blood serum and urine of children with glomerulonephritis who were treated with Prednisolone, among other drugs. The fact that Prednisolone is included in such a study implies that it has been considered as a potential treatment for glomerulonephritis. However, it's important to note that indirect support does not equate to definitive proof. The paper would need to be reviewed in its entirety to fully understand the context of Prednisolone's use and its efficacy in treating glomerulonephritis. Additionally, further research including randomized controlled trials would be necessary to make a definitive conclusion about Prednisolone's effectiveness in treating glomerulonephritis." +9717382,Prednisolone treats hemangioma,1148,"Management of hemangioma included observation, prednisolone, flashlamp-pumped pulsed-dye laser, topical therapy and excision in 68 per cent, 8.6 per cent, 10.7 per cent, 9.6 per cent, and 2.5 per cent, respectively.",True,"'Does the phrase ""Prednisolone treats hemangioma"" receive at least indirect support from the statement: ""Management of hemangioma included observation, prednisolone, flashlamp-pumped pulsed-dye laser, topical therapy and excision in 68 per cent, 8.6 per cent, 10.7 per cent, 9.6 per cent, and 2.5 per cent, respectively.""?","Yes, the statement does provide indirect support for the phrase ""Prednisolone treats hemangioma"". The text mentions that prednisolone was used in the management of hemangioma in 8.6% of cases, which implies that prednisolone was employed as a treatment for hemangioma. However, it is important to note that correlation does not necessarily imply causation - just because prednisolone was used in some hemangioma cases does not automatically mean it is an effective treatment for hemangioma. Further evidence would be needed to confirm its efficacy as a treatment option for hemangioma." +9668241,Prednisolone treats pure red-cell aplasia,1149,The PRCA and AIHA were successfully treated with prednisolone.,True,"'Does the phrase ""Prednisolone treats pure red-cell aplasia"" receive at least indirect support from the statement: ""The PRCA and AIHA were successfully treated with prednisolone.""?","Yes, the statement ""The PRCA and AIHA were successfully treated with prednisolone"" does provide indirect support for the phrase ""Prednisolone treats pure red-cell aplasia"" (PRCA). - In order for this statement to provide indirect support for treating neoplasm, it would be necessary for there to be some evidence that prednisolone treatment led to improvements in tumor size, growth rate, or other factors related to cancer progression in these rats. Without such evidence, it is not appropriate to make conclusions about prednisolone as an effective treatment for neoplasm based solely on this statement. + The reason is that PRCA is mentioned in the statement as one of the conditions that were successfully treated with prednisolone. However, it is essential to note that PRCA is not explicitly stated as being treated alone; instead, it is part of a conjunction that also includes AIHA (autoimmune hemolytic anemia). This shared treatment course suggests that prednisolone may be an effective treatment for PRCA, but it does not definitively prove it because other factors could influence the treatment outcome. - It is crucial for researchers and those interpreting their work to be cautious when drawing conclusions from available evidence. Overstating results can lead to misinformation, misleading conclusions, and potentially inappropriate" -12767794,Prednisolone treats pneumonia,1120,"After recovering from pneumonia, she was treated initially with prednisolone, 30 mg/day, and remained well until she developed hemoptysis at age 34 years.",True,"Is the triple 'Prednisolone treats pneumonia' supported by the sentence: 'After recovering from pneumonia, she was treated initially with prednisolone, 30 mg/day, and remained well until she developed hemoptysis at age 34 years.'?","Yes, while not a direct causal relationship between Prednisolone and treating pneumonia, there is indirect support for it in the statement provided. Prednisolone is known as an anti-inflammatory medication commonly used for treating various conditions such as asthma, COPD (Chronic Obstructive Pulmonary Disease), allergies, arthritis, blood disorders, kidney diseases, lupus, multiple sclerosis, certain skin conditions, thyroid disorders, and some eye disorders. It can also help reduce inflammation in pneumonia cases caused by certain autoimmune disorders like rheumatoid arthritis or lupus. + Additionally, while prednisolone has been used in treating PRCA in some cases, it is not universally effective for all patients due to variations in disease presentation, comorbidities, and individual responses to treatment. Therefore, further investigation into prednisolone's specific effects on PRCA would be necessary for more conclusive evidence of its efficacy in treating that condition alone." +9538921,Prednisolone treats Graves disease,1150,"She was diagnosed as having Graves' disease and was treated with propylthiouracil, and prednisolone was given for neck pain.",True,"'Does the phrase ""Prednisolone treats Graves disease"" receive at least indirect support from the statement: ""She was diagnosed as having Graves' disease and was treated with propylthiouracil, and prednisolone was given for neck pain.""?","Yes, there is indirect support for the phrase ""Prednisolone treats Graves disease"" from the statement provided. The individual was diagnosed with Graves disease and treated with propylthiouracil, which is a common antithyroid medication used to manage hyperthyroidism associated with Graves disease. Additionally, prednisolone was given for neck pain. Prednisolone is a glucocorticoid that possesses anti-inflammatory properties and is sometimes prescribed for managing symptoms related to Graves disease, such as eye inflammation (Graves ophthalmopathy). Therefore, although prednisolone was given for neck pain in this case, it does indirectly support the use of prednisolone in treating Graves disease due to its potential therapeutic benefits for certain symptoms of the disease." +9135976,Prednisolone treats sarcoidosis,1151,"Clinical characteristics, pulmonary function abnormalities and outcome of prednisolone treatment in 106 patients with sarcoidosis.",True,"'Does the phrase ""Prednisolone treats sarcoidosis"" receive at least indirect support from the statement: ""Clinical characteristics, pulmonary function abnormalities and outcome of prednisolone treatment in 106 patients with sarcoidosis.""?","Yes, the phrase ""Prednisolone treats sarcoidosis"" does receive indirect support from the statement ""Clinical characteristics, pulmonary function abnormalities and outcome of prednisolone treatment in 106 patients with sarcoidosis."" - - In this statement, we see that prednisolone was administered after recovery from pneumonia. However, we cannot rule out that prednisolone might have contributed positively towards her recovery process by controlling inflammation caused by pneumonia. It is essential to consider that prednisolone is not typically used as a primary treatment for pneumonia but may be beneficial in specific cases depending on underlying conditions triggering inflammation in pneumonia patients. + The statement suggests that prednisolone has been used in the treatment of sarcoidosis in 106 patients, which implies that prednisolone is considered as a treatment option for sarcoidosis. However, it does not provide direct evidence of the efficacy of prednisolone in treating sarcoidosis. To make a definitive conclusion about the effectiveness of prednisolone in treating sarcoidosis, one would need to examine clinical trial results or meta-analyses that report on the efficacy of prednisolone compared to other treatments or placebos. - - Nonetheless," -12190701,Prednisolone treats castration-resistant prostate carcinoma,1121,Fifteen patients 60 to 80 years old (a mean of 72 years) with hormone-refractory prostate cancer were treated with low dose prednisolone.,True,Is the triple 'Prednisolone treats castration-resistant prostate carcinoma' supported by the sentence: 'Fifteen patients 60 to 80 years old (a mean of 72 years) with hormone-refractory prostate cancer were treated with low dose prednisolone.'?,"Yes, indirectly. The statement does provide some support for the claim that prednisolone can be used in treating prostate cancer, specifically hormone-refractory prostate cancer in patients aged 60 to 80. However, it does not explicitly state that prednisolone treats castration-resistant prostate carcinoma. Castration-resistant prostate carcinoma is a specific type of hormone-refractory prostate cancer, so there is an overlap, but the statement does not cover all cases of castration-resistant prostate carcinoma. Therefore, while it provides some support, it does not fully confirm the initial phrase." -11988157,Prednisolone treats diffuse large B-cell lymphoma,1122,"CHOP (cyclophosphamide, doxorubicin, vincristine and prednisolone) has been the standard chemotherapy regimen used for diffuse large cell lymphomas for over 30 years.",True,"Is the triple 'Prednisolone treats diffuse large B-cell lymphoma' supported by the sentence: 'CHOP (cyclophosphamide, doxorubicin, vincristine and prednisolone) has been the standard chemotherapy regimen used for diffuse large cell lymphomas for over 30 years.'?","Yes, indirectly it does lend support. The statement indicates that CHOP (cyclophosphamide, doxorubicin, vincristine and prednisolone) has been used as a standard chemotherapy regimen for diffuse large cell lymphomas for over 30 years. This implies that each component of CHOP, including prednisolone, contributes positively towards treating diffuse large B-cell lymphoma as part of this combined therapy. However, it is important to note that prednisolone may not be effective in treating diffuse large B-cell lymphoma when used alone, as its primary function within the CHOP regimen is likely as an immunosuppressive agent that enhances the overall treatment efficacy when combined with other chemotherapeutic drugs in the regimen." -11889996,Prednisolone treats mucocutaneous lymph node syndrome,1123,"Six patients with Kawasaki disease (KD) were treated with prednisolone (1 to 2 mg/kg/day) for 3 days (from days 10 to 12 after the onset of the illness) after apparently unsuccessful treatment with intravenous immunoglobulin (IVIG, 2 g/kg/dose and additional 1 g/kg/dose).",True,"Is the triple 'Prednisolone treats mucocutaneous lymph node syndrome' supported by the sentence: 'Six patients with Kawasaki disease (KD) were treated with prednisolone (1 to 2 mg/kg/day) for 3 days (from days 10 to 12 after the onset of the illness) after apparently unsuccessful treatment with intravenous immunoglobulin (IVIG, 2 g/kg/dose and additional 1 g/kg/dose).'?","Yes, the statement does provide indirect support for the claim that prednisolone treats mucocutaneous lymph node syndrome (Kawasaki disease is often referred to as such). The statement describes six patients with Kawasaki disease who were treated with prednisolone after initial treatment with intravenous immunoglobulin (IVIG) was unsuccessful. The fact that prednisolone was used as a secondary treatment suggests that it was considered likely to be effective in treating Kawasaki disease, thus providing indirect support for the claim. + In general, sarcoidosis is a multisystem granulomatous disorder of unknown etiology that can affect virtually any organ system. Corticosteroids such as prednisolone remain the mainstay of therapy for sarcoidosis, although their use is not without risks and side effects. The decision" +9109448,Prednisolone treats psoriatic arthritis,1152,Methotrexate and prednisolone treatment of a child with psoriatic arthritis.,True,"'Does the phrase ""Prednisolone treats psoriatic arthritis"" receive at least indirect support from the statement: ""Methotrexate and prednisolone treatment of a child with psoriatic arthritis.""?","Yes, indirectly it does lend some support to the claim that prednisolone treats psoriatic arthritis. The statement ""Methotrexate and prednisolone treatment of a child with psoriatic arthritis"" implies that both methotrexate and prednisolone were used in the treatment regimen for a patient with psoriatic arthritis. This suggests that prednisolone was considered effective enough for use in treating psoriatic arthritis in this particular case. However, it's important to note that this is not direct evidence of prednisolone's efficacy in treating psoriatic arthritis as it could be confounded by other factors such as the use of methotrexate, patient characteristics, disease severity, etc. Ideally, randomized controlled trials would provide stronger evidence for such a claim." +9077262,Prednisolone treats lymphoma,1153,"This paper presents the results of a prospective study to investigate the prognostic value of clinical staging, histological grading, immunophenotype, mitotic count and average numbers of argyrophilic nucleolar organiser region counts in dogs with multicentric lymphosarcoma treated with a standard chemotherapy protocol comprising vincristine, cyclophosphamide and prednisolone.",True,"'Does the phrase ""Prednisolone treats lymphoma"" receive at least indirect support from the statement: ""This paper presents the results of a prospective study to investigate the prognostic value of clinical staging, histological grading, immunophenotype, mitotic count and average numbers of argyrophilic nucleolar organiser region counts in dogs with multicentric lymphosarcoma treated with a standard chemotherapy protocol comprising vincristine, cyclophosphamide and prednisolone.""?","Yes, while not explicitly stated in the provided text, there is indirect support for the claim that prednisolone treats lymphoma. The statement indicates that dogs with multicentric lymphosarcoma were treated with a standard chemotherapy protocol that includes prednisolone as one of its components. Therefore, it can be inferred that prednisolone is used in treating lymphoma in dogs as part of a broader chemotherapy regimen according to the study presented in this paper. However, it is important to note that prednisolone alone may not be sufficient in treating lymphoma; it is used in combination with other chemotherapy drugs in this specific protocol." +9061500,Prednisolone treats dermatomyositis,1154,"The administration of prednisolone (60 mg/day) was initiated, which resulted in improvement of DM.",True,"'Does the phrase ""Prednisolone treats dermatomyositis"" receive at least indirect support from the statement: ""The administration of prednisolone (60 mg/day) was initiated, which resulted in improvement of DM.""?","Yes, the statement ""The administration of prednisolone (60 mg/day) was initiated, which resulted in improvement of DM"" does lend indirect support to the phrase ""Prednisolone treats dermatomyositis."" Dermatomyositis (DM) is a type of inflammatory myopathy that can be treated with corticosteroids like prednisolone. The improvement of DM symptoms upon prednisolone administration suggests that prednisolone has therapeutic effects on dermatomyositis, providing indirect evidence for its efficacy in treating the condition. However, it is important to note that correlation does not necessarily imply causation, so further investigation would be needed for stronger evidence of prednisolone's direct effects on dermatomyositis." +9046445,Prednisolone treats systemic sclerosis,1155,"METHODS: Resting radionuclide ventriculography with 99mTc was performed before and 20 days after the administration of prednisolone, 20 mg daily, in 32 patients with SSc without clinically evident myocardial dysfunction at rest; 13 and 19 patients with systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA), respectively, were studied in parallel as controls.",True,"'Does the phrase ""Prednisolone treats systemic sclerosis"" receive at least indirect support from the statement: ""METHODS: Resting radionuclide ventriculography with 99mTc was performed before and 20 days after the administration of prednisolone, 20 mg daily, in 32 patients with SSc without clinically evident myocardial dysfunction at rest; 13 and 19 patients with systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA), respectively, were studied in parallel as controls.""?","Yes, indirect support can be inferred from this statement for the phrase ""Prednisolone treats systemic sclerosis (SSc)"". The study design involves administering prednisolone to patients with SSc for 20 days while monitoring their resting radionuclide ventriculography using 99mTc before and after treatment. This suggests an intentional investigation of the effects of prednisolone on SSc patients. However, it is important to note that direct causality cannot be concluded based solely on this information since the study design does not include a control group without prednisolone treatment for comparison. Additionally, while changes in resting radionuclide ventriculography may indicate improvements in cardiac function associated with prednisolone treatment in SSc patients, it does not necessarily equate to treating systemic sclerosis as a whole. Further information regarding clinical outcomes would be needed for more definitive support of prednisolone treating systemic sclerosis." +9013774,Prednisolone treats ocular pemphigoid,1156,METHODS: Three patients with CP were treated with mycophenolate mofetil and prednisolone.,True,"'Does the phrase ""Prednisolone treats ocular pemphigoid"" receive at least indirect support from the statement: ""METHODS: Three patients with CP were treated with mycophenolate mofetil and prednisolone.""?","Yes, indirectly it does support the claim that prednisolone treats ocular pemphigoid. The statement provided indicates that three patients diagnosed with ocular pemphigoid (CP stands for cicatricial pemphigoid, which is a type of ocular pemphigoid) were treated using mycophenolate mofetil and prednisolone together. This suggests that prednisolone is being used as part of an ocular pemphigoid treatment regimen, providing indirect evidence for its use in managing this condition. - However, it is important to note that this is an observational study with a small sample size, which limits the strength of the evidence. Ideally, a randomized controlled trial would be conducted to more definitively establish whether prednisolone is effective in treating Kawasaki disease. Additionally, while prednisolone may be effective in treating Kawasaki disease, it does not necessarily mean it is specifically treating mucocutaneous lymph node syndrome within Kawasaki disease, as Kawasaki disease is a complex condition that may involve multiple pathological processes." -11813573,Prednisolone treats focal segmental glomerulosclerosis,1124,"RESULTS: Of 136 patients with primary FSGS and nephrotic range proteinuria, 76 (56%) were treated with prednisolone and of this group, 59% were treated with additional immunosuppression.",False,"Is the triple 'Prednisolone treats focal segmental glomerulosclerosis' supported by the sentence: 'RESULTS: Of 136 patients with primary FSGS and nephrotic range proteinuria, 76 (56%) were treated with prednisolone and of this group, 59% were treated with additional immunosuppression.'?","No, the statement does not provide direct support for the claim that prednisolone treats focal segmental glomerulosclerosis (FSGS). The statement only indicates that 59% of patients treated with prednisolone (and additional immunosuppression) had an unspecified outcome. There is no mention of whether their FSGS was treated or improved as a result of prednisolone use. Therefore, it is impossible to draw conclusions about prednisolone's effectiveness in treating FSGS based on this information alone. + However, it is important to note that this statement does not offer direct evidence that prednisolone alone treats ocular pemphigoid since it is being used in combination therapy with mycophenolate mofetil in these particular cases. Additionally, it should be emphasized that evidence from clinical trials is necessary for making definitive conclusions about treatment efficacy for medical conditions like ocular pemphigoid." +8939337,Prednisolone treats membranous glomerulonephritis,1157,He was diagnosed as having membranous nephropathy by renal biopsy and was treated with prednisolone.,True,"'Does the phrase ""Prednisolone treats membranous glomerulonephritis"" receive at least indirect support from the statement: ""He was diagnosed as having membranous nephropathy by renal biopsy and was treated with prednisolone.""?","Yes, the statement does provide indirect support for the phrase ""Prednisolone treats membranous glomerulonephritis."" Membranous glomerulonephritis is another term for membranous nephropathy, which is the condition the individual was diagnosed with in the statement. The fact that this individual was treated with prednisolone suggests that prednisolone may be an effective treatment for membranous glomerulonephritis/nephropathy. However, it is important to note that correlation does not imply causation; while prednisolone may have contributed to improving the patient's condition, it does not necessarily mean that prednisolone was solely responsible for treating the membranous glomerulonephritis/nephropathy. Further studies would be required to establish a direct cause-and-effect relationship between prednisolone treatment and recovery from membranous glomerulonephritis/nephropathy." +8906209,Prednisolone treats allergic disease,1158,"Clinically, both prednisolone and prednisolone sodium succinate are widely used as immunosuppressive agents for the treatment of various allergic disorders.",True,"'Does the phrase ""Prednisolone treats allergic disease"" receive at least indirect support from the statement: ""Clinically, both prednisolone and prednisolone sodium succinate are widely used as immunosuppressive agents for the treatment of various allergic disorders.""?","Yes, the statement ""Clinically, both prednisolone and prednisolone sodium succinate are widely used as immunosuppressive agents for the treatment of various allergic disorders"" does provide indirect support for the claim ""Prednisolone treats allergic disease"". - To provide indirect support for the claim that prednisolone treats FSGS, we would need additional information linking prednisolone treatment to improvements in FSGS symptoms or markers. For example, if there were a decrease in proteinuria levels or stabilization/improvement in renal function in patients treated with prednisolone compared to those not treated, that would provide indirect evidence supporting prednisolone as an FSGS treatment option. + Prednisolone is an immunosuppressive agent, which means it suppresses or reduces the activity of the immune system. In the context of allergic disorders, an overactive immune response is responsible for the symptoms experienced by patients. By suppressing this overactive immune response, prednisolone can help alleviate these symptoms. - It is essential in interpreting evidence like this to ensure that causality is not inferred without proper support from well-designed studies that control for potential confounding factors." -11810617,Prednisolone treats congenital adrenal hyperplasia,1125,"METHODS: Growth parameters of twelve children (8 m, 4 f) with congenital adrenal hyperplasia were retrospectively studied while on treatment with prednisolone (PR) earlier and then hydrocortisone (HC) after it became freely available in India.",True,"Is the triple 'Prednisolone treats congenital adrenal hyperplasia' supported by the sentence: 'METHODS: Growth parameters of twelve children (8 m, 4 f) with congenital adrenal hyperplasia were retrospectively studied while on treatment with prednisolone (PR) earlier and then hydrocortisone (HC) after it became freely available in India.'?","Yes, indirect support can be inferred from the statement provided. The methods section describes a retrospective study on growth parameters of children with congenital adrenal hyperplasia (CAH) who were treated with prednisolone (PR) followed by hydrocortisone (HC). The fact that growth parameters were studied in patients receiving PR implies that PR had some therapeutic effect on these patients during treatment, thus lending indirect support to the claim that prednisolone treats congenital adrenal hyperplasia. However, it is important to note that direct causality cannot be determined from this statement alone as other factors influencing growth parameters were not discussed in detail." -11808057,Prednisolone treats keratitis,1126,Ciprofloxacin and prednisolone therapy for experimental Pseudomonas keratitis.,True,Is the triple 'Prednisolone treats keratitis' supported by the sentence: 'Ciprofloxacin and prednisolone therapy for experimental Pseudomonas keratitis.'?,"Yes, the statement ""Ciprofloxacin and prednisolone therapy for experimental Pseudomonas keratitis"" does lend indirect support to the claim that prednisolone treats keratitis. The reason for this is that keratitis is being treated in the experiment using prednisolone as part of a therapeutic regimen alongside ciprofloxacin. + However, it is important to note that while the statement provides indirect support for the claim, it does not constitute direct evidence. Direct evidence would involve clinical trials or studies demonstrating the efficacy of prednisolone in treating specific allergic disorders. The statement only confirms that prednisolone is used in clinical practice for treating allergic disorders, but it does not provide information about its effectiveness." +8865745,Prednisolone treats subacute thyroiditis,1159,CONCLUSIONS: The recurrence rate of SAT with treated PSL is about 20%.,True,"'Does the phrase ""Prednisolone treats subacute thyroiditis"" receive at least indirect support from the statement: ""CONCLUSIONS: The recurrence rate of SAT with treated PSL is about 20%.""?","Yes, indirectly it does lend some support. The statement ""The recurrence rate of SAT (Subacute Thyroiditis) with treated PSL (Prednisolone) is about 20%"" suggests that Prednisolone has some therapeutic effect on Subacute Thyroiditis as evidenced by the reduced recurrence rate. However, it doesn't explicitly state that Prednisolone treats Subacute Thyroiditis, but rather implies that it can help manage symptoms and potentially prevent recurrences when used as a treatment. It is important to note that while this statement suggests a beneficial effect of Prednisolone on Subacute Thyroiditis, further investigation would be required to fully understand its mechanisms of action, efficacy, dosage, potential side effects, and contraindications in treating Subacute Thyroiditis." +8819323,Prednisolone treats meningeal tuberculosis,1160,"In this case, prednisolone was indispensable for treating tuberculous meningitis in combination with appropriate antituberculosis drugs, though the role of corticosteroids has remained controversial over the years.",True,"'Does the phrase ""Prednisolone treats meningeal tuberculosis"" receive at least indirect support from the statement: ""In this case, prednisolone was indispensable for treating tuberculous meningitis in combination with appropriate antituberculosis drugs, though the role of corticosteroids has remained controversial over the years.""?","Yes, the phrase ""Prednisolone treats meningeal tuberculosis"" does receive indirect support from the statement provided. The statement indicates that prednisolone was used in combination with appropriate antituberculosis drugs to treat tuberculous meningitis (a form of meningeal tuberculosis). The term ""indispensable"" suggests that prednisolone played a crucial role in the treatment process. However, it is important to note that the statement also mentions that the role of corticosteroids like prednisolone in treating tuberculous meningitis has been controversial over the years. This implies that while there is evidence supporting their use, more research is needed to fully understand their mechanism of action and optimal use in treatment regimens." +8755027,Prednisolone treats hypereosinophilic syndrome,1161,"Prednisolone (PSL) was administered, which improved the anemia, eosinophilia and the cavities.",True,"'Does the phrase ""Prednisolone treats hypereosinophilic syndrome"" receive at least indirect support from the statement: ""Prednisolone (PSL) was administered, which improved the anemia, eosinophilia and the cavities.""?","Yes, the statement ""Prednisolone (PSL) was administered, which improved the anemia, eosinophilia and the cavities"" does lend indirect support to the claim that Prednisolone treats hypereosinophilic syndrome (HES). This is because eosinophilia is one of the key diagnostic features of HES, characterized by an abnormal increase in eosinophil count in peripheral blood and/or bone marrow. - + Prednisolone is a corticosteroid that has been used in managing HES due to its ability to suppress eosinophil production in the bone marrow. By stating that eosinophilia improved following Prednisolone administration in addition to anemia and cavities, it implies that Prednisolone had an impact on HES-related symptoms and thus supports its potential therapeutic value in treating HES. - However, it is essential to note that while prednisolone is used in treating keratitis in this study, it is not necessarily indicative that prednisolone is solely responsible for treating keratitis in all cases. The study uses both ciprofloxacin and prednisolone in combination for experimental Pseudomonas keratitis specifically. Therefore, it is possible that prednisolone may only be effective in treating certain types of keratitis when used in conjunction with other drugs like ciprofloxacin. + However, it is essential to acknowledge that indirect support does not equate to definitive proof of efficacy for HES treatment. More rigorous clinical trials would be required to establish Prednisolone as an evidence-based treatment for HES." +8752241,Prednisolone treats West syndrome,1162,"BACKGROUND: The use of adrenocorticotrophic hormone (ACTH) and prednisolone in the management of infantile spasms has been well established, but is associated with significant morbidity and cannot be used as long-term medication.",True,"'Does the phrase ""Prednisolone treats West syndrome"" receive at least indirect support from the statement: ""BACKGROUND: The use of adrenocorticotrophic hormone (ACTH) and prednisolone in the management of infantile spasms has been well established, but is associated with significant morbidity and cannot be used as long-term medication.""?","Yes, indirectly it does support that prednisolone treats West syndrome (infantile spasms). The statement mentions both ACTH and prednisolone being used in managing infantile spasms (West syndrome), which implies their effectiveness in treating the condition. However, it also highlights significant morbidity associated with their use, suggesting potential side effects that may prevent their long-term usage. - + To further validate this claim, it would be necessary to review additional literature that specifically investigates prednisolone as a treatment for West syndrome, focusing on its efficacy, safety profile, and comparison to other available treatments. In conclusion, while there is some level of support for prednisolone being used as a treatment for West syndrome based on the provided statement, further investigation is warranted for more definitive conclusions." +8647269,Prednisolone treats pulmonary tuberculosis,1163,"However, he died because of lung tuberculosis and acute tuberculous pericarditis during treatment with prednisolone.",False,"'Does the phrase ""Prednisolone treats pulmonary tuberculosis"" receive at least indirect support from the statement: ""However, he died because of lung tuberculosis and acute tuberculous pericarditis during treatment with prednisolone.""?","No, the phrase ""Prednisolone treats pulmonary tuberculosis"" does not receive indirect support from the statement provided. In fact, the statement suggests that prednisolone may not be effective in treating pulmonary tuberculosis since the patient still died from it despite being on prednisolone treatment. - Additionally, further studies would be required to establish prednisolone as an effective treatment for keratitis outside experimental Pseudomonas keratitis cases, as well as" -11527350,"Prednisolone treats dermatitis, atopic",1127,"Prednicarbate is a non-halogenated, double-ester derivative of prednisolone that has become of interest for the treatment of inflammatory skin diseases, for example atopic dermatitis.",False,"Is the triple 'Prednisolone treats dermatitis, atopic' supported by the sentence: 'Prednicarbate is a non-halogenated, double-ester derivative of prednisolone that has become of interest for the treatment of inflammatory skin diseases, for example atopic dermatitis.'?","No, the statement does not provide direct support for the claim that prednisolone treats atopic dermatitis based on the information about prednicarbate. The passage mentions prednisolone in relation to prednicarbate, which is a derivative of prednisolone used for treating inflammatory skin diseases such as atopic dermatitis. However, it does not explicitly state that prednisolone itself is an effective treatment for atopic dermatitis. + Prednisolone is a corticosteroid often used to suppress inflammation in various conditions such as asthma, allergies, and autoimmune diseases. It is not typically used as a primary treatment for pulmonary tuberculosis, which is caused by Mycobacterium tuberculosis infection. Instead, antibiotics like isoniazid, rifampin, ethambutol, and pyrazinamide are commonly used for treating tuberculosis [1]. - To establish whether prednisolone treats atopic dermatitis, one would need specific evidence indicating its effectiveness in treating that condition. The passage only establishes that prednicarbate is used for treating atopic dermatitis but does not extend that information to prednisolone itself. + The statement indicates that the patient suffered from acute tuberculous pericarditis during prednisolone treatment. Tuberculous pericarditis is an uncommon extrapulmonary manifestation of tuberculosis that can occur due to the hematogenous spread of Mycobacterium tuberculosis [2]. The development" +8583398,Prednisolone treats leprosy,1164,"In untreated reactional leprosy patients, the levels of urinary NO metabolites (1645 +/- 454 microM, n = 9, ENL = 4, RR = 5) decreased significantly 2 weeks after high dose prednisolone treatment (1075 +/- 414 microM, P < 0.05), and remained stable 4 (895 +/- 385 microM, P < 0.02) and 6 weeks following treatment initiation (1048 +/- 452 microM, P < 0.02).",True,"'Does the phrase ""Prednisolone treats leprosy"" receive at least indirect support from the statement: ""In untreated reactional leprosy patients, the levels of urinary NO metabolites (1645 +/- 454 microM, n = 9, ENL = 4, RR = 5) decreased significantly 2 weeks after high dose prednisolone treatment (1075 +/- 414 microM, P < 0.05), and remained stable 4 (895 +/- 385 microM, P < 0.02) and 6 weeks following treatment initiation (1048 +/- 452 microM, P < 0.02).""?","Yes, the statement does provide indirect support for the claim that prednisolone treats leprosy. The study measures urinary nitric oxide (NO) metabolites in reactional leprosy patients before and after prednisolone treatment. The significant decrease in NO metabolites after treatment suggests that prednisolone has an effect on the immune response associated with leprosy reactions. This is relevant because leprosy reactions can cause severe damage to nerves and other tissues if not properly managed. By reducing these reactions, prednisolone could help alleviate symptoms and prevent complications in leprosy patients. However, it is important to note that while prednisolone may help manage leprosy reactions, it does not cure leprosy itself, which is caused by the Mycobacterium leprae bacterium. Therefore, while there is indirect support for prednisolone as a treatment for leprosy-related symptoms, it does not necessarily mean that prednisolone treats leprosy in its entirety." +8573433,Prednisolone treats alcoholic hepatitis,1165,"Prednisolone improves survival in patients with alcoholic hepatitis who have either spontaneous hepatic encephalopathy or a high ""discriminant function.",True,"'Does the phrase ""Prednisolone treats alcoholic hepatitis"" receive at least indirect support from the statement: ""Prednisolone improves survival in patients with alcoholic hepatitis who have either spontaneous hepatic encephalopathy or a high ""discriminant function.""?","Yes, the statement does provide indirect support for the claim that Prednisolone treats alcoholic hepatitis. The provided statement indicates that Prednisolone improves survival in patients with alcoholic hepatitis who have either spontaneous hepatic encephalopathy or a high ""discriminant function."" This suggests that Prednisolone has a positive effect on the condition of alcoholic hepatitis, thus providing support for the claim that it treats the disease. However, it is important to note that the statement does not directly mention that Prednisolone treats alcoholic hepatitis, but rather implies it through its effects on survival in specific patient populations. Therefore, while there is indirect support for the claim, it is not a direct confirmation." +8540122,Prednisolone treats autoimmune hemolytic anemia,1166,She had received prednisolone (PSL) therapy for autoimmune hemolytic anemia (AIHA).,True,"'Does the phrase ""Prednisolone treats autoimmune hemolytic anemia"" receive at least indirect support from the statement: ""She had received prednisolone (PSL) therapy for autoimmune hemolytic anemia (AIHA).""?","Yes, the statement ""She had received prednisolone (PSL) therapy for autoimmune hemolytic anemia (AIHA)"" does provide indirect support for the phrase ""Prednisolone treats autoimmune hemolytic anemia."" This is because it indicates that prednisolone was used as a treatment for autoimmune hemolytic anemia in a specific case, implying that prednisolone has some therapeutic effect on this condition. However, it should be noted that this does not constitute direct evidence of treatment efficacy, as it does not include information about the patient's response to treatment or any comparative analysis with other treatments or no treatment at all. Therefore, while it suggests that prednisolone may be useful in treating AIHA, it does not definitively prove that prednisolone treats AIHA." +8499057,Prednisolone treats lupus nephritis,1167,"CONCLUSIONS: For the treatment of diffuse proliferative lupus nephritis, the combination of mycophenolate mofetil and prednisolone is as effective as a regimen of cyclophosphamide and prednisolone followed by azathioprine and prednisolone but is less toxic.",True,"'Does the phrase ""Prednisolone treats lupus nephritis"" receive at least indirect support from the statement: ""CONCLUSIONS: For the treatment of diffuse proliferative lupus nephritis, the combination of mycophenolate mofetil and prednisolone is as effective as a regimen of cyclophosphamide and prednisolone followed by azathioprine and prednisolone but is less toxic.""?","Yes, the statement does provide indirect support for the claim that prednisolone treats lupus nephritis. The conclusion of the study indicates that prednisolone, when used in combination with mycophenolate mofetil, is effective in treating diffuse proliferative lupus nephritis. This implies that prednisolone has therapeutic benefits in treating lupus nephritis, thus supporting the claim. However, it should be noted that prednisolone is not acting alone in this context, but rather in conjunction with other treatments. Therefore, while the statement does provide indirect support for the claim, it does not conclusively prove that prednisolone alone treats lupus nephritis." +8455402,Prednisolone treats chronic obstructive pulmonary disease,1168,Additive effects of prednisolone and beclomethasone dipropionate in patients with stable chronic obstructive pulmonary disease.,True,"'Does the phrase ""Prednisolone treats chronic obstructive pulmonary disease"" receive at least indirect support from the statement: ""Additive effects of prednisolone and beclomethasone dipropionate in patients with stable chronic obstructive pulmonary disease.""?","Yes, indirectly it does lend some support. The statement suggests that prednisolone, when used in combination with beclomethasone dipropionate, has additive effects in patients with stable chronic obstructive pulmonary disease (COPD). This implies that prednisolone is active in COPD patients, which aligns with the phrase ""Prednisolone treats chronic obstructive pulmonary disease."" However, it's important to note that the original statement does not explicitly state that prednisolone treats COPD on its own, hence the indirect support. Also, the term ""treats"" can be interpreted in different ways, such as improving symptoms, slowing progression, or curing the disease, which may not all be applicable here based on the information provided." +8268574,Prednisolone treats thrombocytopenia,1169,Three out of 8 patients with thrombocytopenia were treated with prednisolone according to the protocol for idiopathic thrombocytopenic purpura.,True,"'Does the phrase ""Prednisolone treats thrombocytopenia"" receive at least indirect support from the statement: ""Three out of 8 patients with thrombocytopenia were treated with prednisolone according to the protocol for idiopathic thrombocytopenic purpura.""?","Yes, the statement does provide indirect support for the phrase ""Prednisolone treats thrombocytopenia."" The fact that three out of eight patients with thrombocytopenia were treated with prednisolone according to a specific protocol for idiopathic thrombocytopenic purpura suggests that prednisolone is being used as a treatment for thrombocytopenia in this context. However, it is important to note that correlation does not imply causation; simply because prednisolone was administered to these patients does not necessarily mean it was responsible for any improvement in their condition. To establish more direct support for the claim that prednisolone treats thrombocytopenia, further evidence such as controlled clinical trials demonstrating the efficacy of prednisolone in treating thrombocytopenia would be needed." +7990669,Prednisolone treats non-Hodgkin lymphoma,1170,"A regimen which incorporates cyclophosphamide, doxorubicin, vincristine and prednisolone (CHOP) is the standard treatment for patients with non-Hodgkin's lymphoma (NHL), but it has not been effective in patients with aggressive NHL who are at high risk.",True,"'Does the phrase ""Prednisolone treats non-Hodgkin lymphoma"" receive at least indirect support from the statement: ""A regimen which incorporates cyclophosphamide, doxorubicin, vincristine and prednisolone (CHOP) is the standard treatment for patients with non-Hodgkin's lymphoma (NHL), but it has not been effective in patients with aggressive NHL who are at high risk.""?","Yes, indirect support can be inferred from this statement. The claim specifically mentions prednisolone as part of a standard treatment regimen for non-Hodgkin lymphoma (NHL). Although it is noted that this regimen may not be effective in patients with aggressive NHL who are at high risk, it does not negate the fact that prednisolone is used in treating NHL. Therefore, while prednisolone may not be sufficient on its own or in all cases of NHL treatment, it does form part of an effective treatment regimen for some patients with NHL. However, it is important to note that prednisolone is typically used in combination therapy for NHL treatment, as is indicated in the provided statement." +7986379,Prednisolone treats Crohn disease,1171,"In a stepwise regression that included age, sex, disease duration and cumulative prednisolone dose as independent variables, the femur T score was significantly inversely related to disease duration (r2 = 0.125, F = 6.06) in CD patients.",False,"'Does the phrase ""Prednisolone treats Crohn disease"" receive at least indirect support from the statement: ""In a stepwise regression that included age, sex, disease duration and cumulative prednisolone dose as independent variables, the femur T score was significantly inversely related to disease duration (r2 = 0.125, F = 6.06) in CD patients.""?","No, the statement does not provide direct or indirect support for the claim that Prednisolone treats Crohn disease (CD). The study mentioned in the statement investigates the relationship between various factors including age, sex, disease duration, cumulative prednisolone dose, and femur T score in CD patients. Although it shows an inverse relationship between disease duration and femur T score in CD patients, it does not demonstrate that Prednisolone is responsible for treating Crohn disease. - While it is possible that prednisolone could be an effective treatment for atopic dermatitis given its relationship to prednicarbate, further investigation would be required to confirm such a claim based on direct evidence rather than inference alone." -11526277,Prednisolone treats kidney disorder,1128,"AIM: To evaluate the efficacy of prednisolone, warfarin, and dipyridamole therapy combined with mizoribine (PWDM) in the treatment of diffuse immunoglobulin A (IgA) nephropathy in comparison with prednisolone, warfarin, and dipyridamole therapy without mizoribine (PWD) and with methylprednisolone pulse therapy (PWD pulse).",False,"Is the triple 'Prednisolone treats kidney disorder' supported by the sentence: 'AIM: To evaluate the efficacy of prednisolone, warfarin, and dipyridamole therapy combined with mizoribine (PWDM) in the treatment of diffuse immunoglobulin A (IgA) nephropathy in comparison with prednisolone, warfarin, and dipyridamole therapy without mizoribine (PWD) and with methylprednisolone pulse therapy (PWD pulse).'?","No, the statement does not provide direct support for the phrase ""Prednisolone treats kidney disorder"". However, it does offer indirect evidence that prednisolone might be used in treating diffuse immunoglobulin A (IgA) nephropathy, which is indeed a kidney disorder. The statement is about an aim to evaluate different therapies for IgA nephropathy treatment, one of which includes prednisolone. But it doesn't confirm that prednisolone alone treats kidney disorders; it only suggests its potential use in treating IgA nephropathy in particular. + The study only establishes an association between cumulative prednisolone dose and femur T score in CD patients but does not prove causation nor does it provide evidence that prednisolone is an effective treatment for Crohn disease specifically. To establish that Prednisolone treats Crohn disease, there should be direct evidence demonstrating its efficacy in treating or alleviating CD symptoms in well-designed clinical trials. - - The nuance here is that while prednisolone is part of some therapies for kidney disorders like IgA nephropathy, it does not necessarily mean that prednisolone alone is sufficient for treating kidney disorders generally. The statement at hand only discusses its use in specific therapies for IgA nephropathy treatment." -11497678,Prednisolone treats infertility disorder,1129,"In this double blind cross-over study, 20 infertile men, who had sperm antibodies detected by the mixed antiglobulin reaction (MAR test) in the ejaculate and by the tray agglutination test (TAT) in serum, were treated with 40 mg/day prednisolone or placebo from days 1 to 10 of the partners' menstrual cycle.",False,"Is the triple 'Prednisolone treats infertility disorder' supported by the sentence: 'In this double blind cross-over study, 20 infertile men, who had sperm antibodies detected by the mixed antiglobulin reaction (MAR test) in the ejaculate and by the tray agglutination test (TAT) in serum, were treated with 40 mg/day prednisolone or placebo from days 1 to 10 of the partners' menstrual cycle.'?","No, the statement does not provide direct support for the claim that prednisolone treats infertility disorder. The study mentioned is investigating the effect of prednisolone on infertile men with sperm antibodies, not infertility disorder in general. The specific population studied here is not representative enough for us to make generalizations about prednisolone's impact on infertility disorder as a whole. + In summary, while prednisolone may have some impact on bone health in CD patients as suggested by the study, it does not necessarily mean that it can be used as a treatment for Crohn disease itself. Further investigation is required to determine if Prednisolone has any therapeutic" +7985554,Prednisolone treats acute lymphoblastic leukemia,1172,"A regime of treatment of acute non-lymphoblastic leukemia in adult, employing DMCP protocol, especially two step method consisting of daunorubicin, cytosine arabinoside, 6-mercaptopurine and prednisolone is described.",False,"'Does the phrase ""Prednisolone treats acute lymphoblastic leukemia"" receive at least indirect support from the statement: ""A regime of treatment of acute non-lymphoblastic leukemia in adult, employing DMCP protocol, especially two step method consisting of daunorubicin, cytosine arabinoside, 6-mercaptopurine and prednisolone is described.""?","No, the statement does not provide direct or indirect support for the claim that Prednisolone treats acute lymphoblastic leukemia. The statement describes a treatment regimen for acute non-lymphoblastic leukemia in adults using the DMCP protocol, which includes Prednisolone as part of its two-step method. However, it specifically mentions acute non-lymphoblastic leukemia, not acute lymphoblastic leukemia. These two types of leukemia are distinct diseases that may require different treatment approaches. Therefore, it is not valid to infer that Prednisolone is an effective treatment for acute lymphoblastic leukemia based on this statement alone." +7941298,Prednisolone treats granulomatosis with polyangiitis,1173,"Two patients with Wegener's granulomatosis have been treated with chlorambucil and prednisolone continuosly for 3 and 5 years, respectively.",True,"'Does the phrase ""Prednisolone treats granulomatosis with polyangiitis"" receive at least indirect support from the statement: ""Two patients with Wegener's granulomatosis have been treated with chlorambucil and prednisolone continuosly for 3 and 5 years, respectively.""?","Yes, the statement does provide indirect support for the claim that prednisolone treats granulomatosis with polyangiitis (GPA), also known as Wegener's granulomatosis. The statement indicates that two patients diagnosed with Wegener's granulomatosis were treated with prednisolone continuously for 3 and 5 years respectively, which implies that prednisolone was an effective treatment for these patients during that period. - However, it is important to note that studies like these can contribute valuable information about potential treatments for specific subsets of infertile individuals. In this case, if prednisolone were found to be effective in reducing sperm antibodies in infertile men, it could be considered as a treatment option for that specific group. Nonetheless, further investigation would be required before making definitive conclusions about prednisolone's effectiveness in treating infertility disorders more broadly." -11373326,Prednisolone treats prostate cancer,1130,BACKGROUND: We conducted this retrospective study to analyze a modified dose schedule of mitoxantrone and prednisolone (MP) in patients with androgen-independent prostate cancer.,False,Is the triple 'Prednisolone treats prostate cancer' supported by the sentence: 'BACKGROUND: We conducted this retrospective study to analyze a modified dose schedule of mitoxantrone and prednisolone (MP) in patients with androgen-independent prostate cancer.'?,"No, the statement does not provide indirect support for the claim that ""Prednisolone treats prostate cancer."" The study mentioned is analyzing a modified dose schedule of mitoxantrone in combination with prednisolone for treating patients with androgen-independent prostate cancer. While prednisolone is indeed part of the treatment regimen being investigated in the study, it does not imply that prednisolone alone is responsible for treating prostate cancer since it is used in conjunction with mitoxantrone in this specific study design. + However, it is important to note that correlation does not imply causation; therefore, while prednisolone may be associated with improved health outcomes in these patients, it does not necessarily mean that prednisolone was solely responsible for treating their GPA. It is possible that other factors, such as chlorambucil (also mentioned in the statement), could have contributed to their improved health outcomes. - To provide indirect support for the claim ""Prednisolone treats prostate cancer,"" one would need evidence showing that prednisolone alone has a therapeutic effect on prostate cancer in either preclinical models (such as cell lines or animal models) or clinical trials specifically examining prednisolone as monotherapy for prostate cancer treatment." -11166363,Prednisolone treats canker sore,1131,"It has also been used in combination with other drugs for treating a number of dermatologic disorders, e.g. in combination with cimetidine for treating recalcitrant warts, with prednisolone for treating lichen planus, erythema multiforme and aphthous ulcers of the mouth.",True,"Is the triple 'Prednisolone treats canker sore' supported by the sentence: 'It has also been used in combination with other drugs for treating a number of dermatologic disorders, e.g. in combination with cimetidine for treating recalcitrant warts, with prednisolone for treating lichen planus, erythema multiforme and aphthous ulcers of the mouth.'?","Yes, the statement does provide indirect support for the claim that prednisolone treats canker sores (aphthous ulcers of the mouth). The text explicitly mentions prednisolone being used in combination with other drugs for treating lichen planus, erythema multiforme, and specifically mentions its use for treating ""aphthous ulcers of the mouth,"" which is another term for canker sores. However, it is essential to note that the statement refers to prednisolone being used in combination with other drugs for these conditions, not as a standalone treatment. This nuance is crucial when interpreting the evidence provided in the statement." -11166362,Prednisolone treats lichen planus,1132,"It has also been used in combination with other drugs for treating a number of dermatologic disorders, e.g. in combination with cimetidine for treating recalcitrant warts, with prednisolone for treating lichen planus, erythema multiforme and aphthous ulcers of the mouth.",True,"Is the triple 'Prednisolone treats lichen planus' supported by the sentence: 'It has also been used in combination with other drugs for treating a number of dermatologic disorders, e.g. in combination with cimetidine for treating recalcitrant warts, with prednisolone for treating lichen planus, erythema multiforme and aphthous ulcers of the mouth.'?","Yes, the phrase ""Prednisolone treats lichen planus"" does receive indirect support from the statement provided. The statement mentions that prednisolone has been used in combination with other drugs for treating certain dermatologic disorders, including lichen planus. This implies that prednisolone has some efficacy in treating lichen planus, even if it is typically used in conjunction with other treatments. However, it is important to note that this is indirect evidence and further, more direct research may be necessary to fully support this claim." -11166361,Prednisolone treats erythema multiforme,1133,"It has also been used in combination with other drugs for treating a number of dermatologic disorders, e.g. in combination with cimetidine for treating recalcitrant warts, with prednisolone for treating lichen planus, erythema multiforme and aphthous ulcers of the mouth.",True,"Is the triple 'Prednisolone treats erythema multiforme' supported by the sentence: 'It has also been used in combination with other drugs for treating a number of dermatologic disorders, e.g. in combination with cimetidine for treating recalcitrant warts, with prednisolone for treating lichen planus, erythema multiforme and aphthous ulcers of the mouth.'?","Yes, the statement does provide indirect support for the claim that prednisolone treats erythema multiforme. The provided text mentions that prednisolone is used in combination with other drugs for treating lichen planus, erythema multiforme, and aphthous ulcers of the mouth. This indicates that prednisolone has been applied in therapeutic settings for managing erythema multiforme, thus lending indirect support to the claim that prednisolone can be used for treating erythema multiforme. + Moreover, since granulomatosis with polyangiitis is a complex disease that can manifest differently in different individuals, it is possible that prednisolone may not be an effective treatment for all patients diagnosed with GPA. Further studies involving larger sample sizes would be needed to establish more definitive evidence for the effectiveness of prednisolone" +7927983,Prednisolone treats nephrotic syndrome,1174,"The second patient, a 73-year-old man receiving prednisolone therapy for nephrotic syndrome, developed right leg cellulitis that evolved to NF.",False,"'Does the phrase ""Prednisolone treats nephrotic syndrome"" receive at least indirect support from the statement: ""The second patient, a 73-year-old man receiving prednisolone therapy for nephrotic syndrome, developed right leg cellulitis that evolved to NF.""?","No, the statement does not provide direct or indirect support for the claim that prednisolone treats nephrotic syndrome. In fact, it suggests that prednisolone may be associated with an adverse effect (cellulitis) in a patient receiving treatment for nephrotic syndrome. This observation does not necessarily imply that prednisolone is ineffective at treating nephrotic syndrome; however, it does not offer any evidence supporting its therapeutic effect in this context either. Therefore, further investigation is required before drawing any conclusions about prednisolone's effectiveness in treating nephrotic syndrome based on this statement alone." +7900660,Prednisolone treats temporal arteritis,1175,"At the time of diagnosis, patients with GCA had an increased median serum level of YKL-40 (256 microg/liter; P<0.01) compared with healthy age-matched controls (median 118 microg/liter), and the serum level of YKL-40 decreased to normal levels during prednisolone treatment (-38% after 1 month; P<0.001).",True,"'Does the phrase ""Prednisolone treats temporal arteritis"" receive at least indirect support from the statement: ""At the time of diagnosis, patients with GCA had an increased median serum level of YKL-40 (256 microg/liter; P<0.01) compared with healthy age-matched controls (median 118 microg/liter), and the serum level of YKL-40 decreased to normal levels during prednisolone treatment (-38% after 1 month; P<0.001).""?","Yes, the statement does provide indirect support for the claim that prednisolone treats temporal arteritis. The study found that patients diagnosed with giant cell arteritis (GCA), a type of temporal arteritis, had elevated levels of YKL-40 at diagnosis compared to healthy controls. Importantly, treatment with prednisolone was associated with a significant decrease in YKL-40 levels after one month (-38%; P<0.001). This finding suggests that prednisolone may have an impact on the biological processes driving GCA, as YKL-40 has been implicated in inflammation and tissue remodeling associated with GCA. However, it is important to note that while this evidence supports prednisolone as an effective treatment for reducing YKL-40 levels in GCA patients, it does not necessarily prove that prednisolone treats temporal arteritis in general, as GCA represents only one form of temporal arteritis. Further studies would be needed to confirm these findings in other forms of temporal arteritis and assess other potential therapeutic options." +7900659,Prednisolone treats polymyalgia rheumatica,1176,Most patients with PMR had normal serum YKL-40 levels (median 158 microg/liter) and had no changes in the serum YKL-40 levels during prednisolone treatment.,False,"'Does the phrase ""Prednisolone treats polymyalgia rheumatica"" receive at least indirect support from the statement: ""Most patients with PMR had normal serum YKL-40 levels (median 158 microg/liter) and had no changes in the serum YKL-40 levels during prednisolone treatment.""?","No, the statement does not provide indirect support for the claim that prednisolone treats polymyalgia rheumatica (PMR). The statement indicates that most patients with PMR have normal serum YKL-40 levels and that these levels do not change during prednisolone treatment. This information does not necessarily imply that prednisolone is an effective treatment for PMR. The effectiveness of prednisolone in treating PMR would need to be evaluated through clinical trials that assess disease activity and patient outcomes in response to prednisolone treatment. Therefore, while prednisolone may be used in the treatment of PMR, the statement provided does not offer evidence of its efficacy in treating the condition." +7866839,Prednisolone treats acute myeloid leukemia,1177,"Treatment of acute myeloid leukemia of childhood with cytosine arabinoside, daunorubicin, prednisolone, and mercaptopurine or thioguanine.",True,"'Does the phrase ""Prednisolone treats acute myeloid leukemia"" receive at least indirect support from the statement: ""Treatment of acute myeloid leukemia of childhood with cytosine arabinoside, daunorubicin, prednisolone, and mercaptopurine or thioguanine.""?","Yes, the phrase ""Prednisolone treats acute myeloid leukemia"" does receive indirect support from the statement provided. The statement indicates that prednisolone is used in the treatment of acute myeloid leukemia of childhood in combination with other drugs such as cytosine arabinoside, daunorubicin, mercaptopurine or thioguanine. This suggests that prednisolone has some therapeutic effect against acute myeloid leukemia, thus providing indirect support for the claim. However, it is important to note that prednisolone is rarely used as a single agent in treating acute myeloid leukemia due to its lower efficacy compared to other drugs mentioned in the statement." +7819165,Prednisolone treats systemic lupus erythematosus,1178,Subacute severe steatohepatitis during prednisolone therapy for systemic lupus erythematosis.,True,"'Does the phrase ""Prednisolone treats systemic lupus erythematosus"" receive at least indirect support from the statement: ""Subacute severe steatohepatitis during prednisolone therapy for systemic lupus erythematosis.""?","Yes, there is indirect support for the claim that ""Prednisolone treats systemic lupus erythematosus"" based on the statement ""Subacute severe steatohepatitis during prednisolone therapy for systemic lupus erythematosis."" - - However, it is important to note that the statement does not offer direct evidence that prednisolone alone is sufficient for treating erythema multiforme. The text specifically mentions its use in combination with other drugs for treating erythema multiforme, suggesting that further investigation may be required to establish prednisolone's independent efficacy in treating this condition. + The key word here is ""therapy,"" which implies that prednisolone is being used as a treatment for systemic lupus erythematosus (SLE). The fact that steatohepatitis (a type of liver disease) is occurring during this therapy does not negate the fact that prednisolone is being used as a treatment for SLE. + Prednisolone is a corticosteroid often used in the treatment of SLE due to its anti-inflammatory effects. However, it is important to note that prednisolone is not a cure for SLE and can have significant side effects, such as steatohepatitis, especially with long-term use. Therefore, while prednisolone can be an effective treatment for SLE, it must be used carefully and often in conjunction with other therapies." +7800931,Prednisolone treats autoimmune thrombocytopenic purpura,1179,"However, after administration of immunoglobulin (IVIG) (0.4 g/kg/day x 5 days), low-dose PSL (20 mg/day) alleviated the LEMS and ITP, and the diseases have remained in remission for 8 months without additional IVIG.",True,"'Does the phrase ""Prednisolone treats autoimmune thrombocytopenic purpura"" receive at least indirect support from the statement: ""However, after administration of immunoglobulin (IVIG) (0.4 g/kg/day x 5 days), low-dose PSL (20 mg/day) alleviated the LEMS and ITP, and the diseases have remained in remission for 8 months without additional IVIG.""?","Yes, the statement does provide indirect support for the claim that Prednisolone (PSL) treats autoimmune thrombocytopenic purpura (ITP). The user statement describes a patient suffering from both Lambert-Eaton myasthenic syndrome (LEMS) and ITP. After treatment with intravenous immunoglobulin (IVIG) and low-dose Prednisolone (PSL), both conditions went into remission for eight months without further IVIG treatment. Since Prednisolone was administered in combination with IVIG and resulted in ITP remission, it suggests that Prednisolone might have contributed to treating ITP in this specific case. However, it is essential to note that controlled clinical trials are necessary for establishing direct causality and efficacy of Prednisolone in treating ITP." +7704078,Prednisolone treats colitis,1180,"On the other hand, prednisolone and short chain fatty acids seemed to improve only the physiologic changes of colitis.",True,"'Does the phrase ""Prednisolone treats colitis"" receive at least indirect support from the statement: ""On the other hand, prednisolone and short chain fatty acids seemed to improve only the physiologic changes of colitis.""?","Yes, the phrase ""Prednisolone treats colitis"" does receive indirect support from the statement ""On the other hand, prednisolone and short chain fatty acids seemed to improve only the physiologic changes of colitis."" - Additionally, it should be emphasized that any interpretation of therapeutic efficacy should be based on rigorous evaluation of clinical trial data and systematic reviews rather than isolated statements from various sources. This ensures that conclusions" -10782301,Prednisolone treats adrenocortical insufficiency,1134,Prednisolone in the treatment of adrenal insufficiency: a re-evaluation of relative potency.,True,Is the triple 'Prednisolone treats adrenocortical insufficiency' supported by the sentence: 'Prednisolone in the treatment of adrenal insufficiency: a re-evaluation of relative potency.'?,"Yes, the phrase ""Prednisolone treats adrenocortical insufficiency"" does receive indirect support from the statement: ""Prednisolone in the treatment of adrenal insufficiency: a re-evaluation of relative potency."" This is because the paper title suggests that prednisolone is being considered for treatment in cases of adrenal insufficiency (also known as adrenocortical insufficiency). However, it is important to note that this does not constitute direct evidence; rather, it indicates that further investigation into the study is warranted to confirm prednisolone's efficacy in treating adrenocortical insufficiency." -10757066,Prednisolone treats atopic eczema,1135,[Results of prednisolone therapy of eczemas in very young and older infants].,True,Is the triple 'Prednisolone treats atopic eczema' supported by the sentence: '[Results of prednisolone therapy of eczemas in very young and older infants].'?,"Yes, the statement ""Prednisolone treats atopic eczema"" does receive indirect support from the provided context: ""[Results of prednisolone therapy of eczemas in very young and older infants]."" This is due to the fact that eczema is mentioned in conjunction with prednisolone therapy within the statement. However, it is important to note that direct support would require more explicit information regarding prednisolone's impact on atopic eczema specifically. Nonetheless, given that eczema is acknowledged as being treated by prednisolone therapy in both young and older infants within the statement, there is an implication that prednisolone could potentially be an effective treatment for atopic eczema in general. + The statement suggests that prednisolone has an effect on colitis, as evidenced by the improvement in physiologic changes. While it does not explicitly state that prednisolone treats colitis, it implies that prednisolone has some therapeutic effect on the condition. The term ""treats"" generally implies an improvement in symptoms or outcomes, which aligns with the mentioned improvement in physiologic changes. However, it is important to note that the evidence provided is indirect and further research would be needed to confirm the therapeutic effect of prednisolone on colitis." +7676165,Prednisolone treats hypercalcemia disease,1181,"Treatment with extracorporeal shock wave lithotripsy, transurethral lithotomy, saline infusion, and prednisolone (30 mg/day) alleviated the urolithiasis, renal insufficiency, and hypercalcemia.",True,"'Does the phrase ""Prednisolone treats hypercalcemia disease"" receive at least indirect support from the statement: ""Treatment with extracorporeal shock wave lithotripsy, transurethral lithotomy, saline infusion, and prednisolone (30 mg/day) alleviated the urolithiasis, renal insufficiency, and hypercalcemia.""?","Yes, the statement does provide indirect support for the claim that prednisolone treats hypercalcemia disease. The case report mentions that treatment involving prednisolone (30 mg/day) was associated with alleviation of hypercalcemia in addition to urolithiasis and renal insufficiency. Hypercalcemia is an elevated calcium level in the blood that may be caused by several diseases including hyperparathyroidism and cancer. Prednisolone is known to have glucocorticoid properties that can inhibit bone resorption and decrease calcium levels in blood; hence, it could be inferred that prednisolone contributed to improving hypercalcemia in this case. However, it is important to note that prednisolone was used in combination with other treatments such as extracorporeal shock wave lithotripsy, transurethral lithotomy, and saline infusion; therefore, its specific effect on hypercalcemia cannot be definitively separated from these other interventions in this single case report. Further studies would be needed to establish a direct causal relationship between prednisolone use and hypercalce" +7603475,Prednisolone treats Duchenne muscular dystrophy,1182,A special program for long-term application of low-dose prednisolone treatment in Duchenne-Becker muscular dystrophy with complex control of the patients' state was developed.,True,"'Does the phrase ""Prednisolone treats Duchenne muscular dystrophy"" receive at least indirect support from the statement: ""A special program for long-term application of low-dose prednisolone treatment in Duchenne-Becker muscular dystrophy with complex control of the patients' state was developed.""?","Yes, indirect support can be inferred from the statement. The development of a long-term application program for low-dose prednisolone treatment in Duchenne-Becker muscular dystrophy suggests that prednisolone may have therapeutic benefits for these patients. However, it does not explicitly state that prednisolone treats Duchenne muscular dystrophy (DMD). Duchenne-Becker muscular dystrophy is a spectrum of diseases that includes DMD, so any positive effects on Duchenne-Becker patients could potentially extend to DMD patients as well. Nonetheless, further direct evidence would be required for a definitive conclusion about prednisolone's efficacy in treating DMD specifically." +7600829,Prednisolone treats multiple sclerosis,1183,"Long-term open-trial of mizoribine with prednisolone in 24 patients with multiple sclerosis: safety, clinical and magnetic resonance imaging outcome.",True,"'Does the phrase ""Prednisolone treats multiple sclerosis"" receive at least indirect support from the statement: ""Long-term open-trial of mizoribine with prednisolone in 24 patients with multiple sclerosis: safety, clinical and magnetic resonance imaging outcome.""?","Yes, indirect support can be inferred from the statement provided, but it is important to clarify that prednisolone alone does not treat multiple sclerosis (MS). Prednisolone is a corticosteroid often used in conjunction with other medications to manage symptoms of MS due to its anti-inflammatory properties. The study mentioned is an open-trial of mizoribine (an immunosuppressive agent) combined with prednisolone in MS patients. The positive outcomes from this trial suggest that prednisolone might play a beneficial role in treating MS as part of a combination therapy; however, it does not imply that prednisolone is sufficient as monotherapy for treating MS." +7586864,Prednisolone treats ulcerative colitis,1184,A 25-year-old man had been treated with high-dose prednisolone for UC.,True,"'Does the phrase ""Prednisolone treats ulcerative colitis"" receive at least indirect support from the statement: ""A 25-year-old man had been treated with high-dose prednisolone for UC.""?","Yes, the statement ""A 25-year-old man had been treated with high-dose prednisolone for UC"" does provide indirect support for the claim that prednisolone treats ulcerative colitis (UC). - To further elaborate on this interpretation, let us consider some relevant background information about prednisolone and eczema. Prednisolone is a synthetic glucocorticoid that has been widely used as an anti-inflammatory agent in various dermatological conditions including eczema (also known as dermatitis) [1]. The term ""eczema"" encompasses several subtypes such as atopic e" -10671990,Prednisolone treats Headache,1136,"We report a patient with neuro-Behcet's syndrome presenting with headache and personality change in whom CT and MRI brain imaging was normal, but regional cerebral blood flow imaging using single photon emission tomography with the tracer HMPAO showed extensive perfusion deficits which partially reversed after 3 months of prednisolone therapy.",True,"Is the triple 'Prednisolone treats Headache' supported by the sentence: 'We report a patient with neuro-Behcet's syndrome presenting with headache and personality change in whom CT and MRI brain imaging was normal, but regional cerebral blood flow imaging using single photon emission tomography with the tracer HMPAO showed extensive perfusion deficits which partially reversed after 3 months of prednisolone therapy.'?","Yes, indirectly it does support the statement that Prednisolone treats headache in certain conditions such as neuro-Behcet's syndrome. The passage mentions a patient presenting with headache as one of the symptoms, who underwent treatment involving Prednisolone. The notable point here is that after 3 months of Prednisolone therapy, there was a partial reversal in regional cerebral blood flow deficits as observed through single photon emission tomography (SPECT) imaging using HMPAO tracer. Although not explicitly stated in the passage that Prednisolone was responsible for reversing headaches, it can be inferred that Prednisolone had some beneficial effect on the patient's neurological condition given that headache was one of their symptoms. However, it is essential to note that any conclusions drawn from single case reports should be considered preliminary and require further investigation in larger controlled studies before making definitive statements about Prednisolone as an effective treatment for headaches related to neuro-Behcet's syndrome specifically or headaches in general." -10574410,Prednisolone treats synovitis,1137,Prednisolone (meticortelone) in treatment of epicondylitis; radiohumeral bursitis and radiohumeral synovitis.,True,Is the triple 'Prednisolone treats synovitis' supported by the sentence: 'Prednisolone (meticortelone) in treatment of epicondylitis; radiohumeral bursitis and radiohumeral synovitis.'?,"Yes, the statement ""Prednisolone (meticortelone) in treatment of epicondylitis; radiohumeral bursitis and radiohumeral synovitis"" does provide indirect support for the claim that ""Prednisolone treats synovitis"". The reason is that synovitis is specifically mentioned in the list of conditions treated by prednisolone (meticortelone). Synovitis refers to inflammation of the synovial membrane that lines joints, bursae, and tendon sheaths - which is why it is mentioned in association with radiohumeral bursitis (inflammation of the bursa in the elbow) as well as radiohumeral synovitis (inflammation of the synovial membrane in the elbow). Therefore, it can be inferred that prednisolone has some efficacy in treating synovitis based on its use in treating these related conditions that involve synovial inflammation. However, it is important to note that direct clinical trials focusing specifically on prednisolone for treating synovitis would provide stronger evidence than an indirect inference based on related conditions." -10574409,Prednisolone treats epicondylitis,1138,Prednisolone (meticortelone) in treatment of epicondylitis; radiohumeral bursitis and radiohumeral synovitis.,True,Is the triple 'Prednisolone treats epicondylitis' supported by the sentence: 'Prednisolone (meticortelone) in treatment of epicondylitis; radiohumeral bursitis and radiohumeral synovitis.'?,"Yes, the statement ""Prednisolone (meticortelone) in treatment of epicondylitis; radiohumeral bursitis and radiohumeral synovitis"" does provide indirect support for the claim that ""Prednisolone treats epicondylitis"". The reason being that prednisolone is listed as one of the treatments for epicondylitis in the provided statement. However, it is important to note that prednisolone is mentioned alongside meticortelone in the original statement, which might lead to confusion as they are two different drugs. Meticortelone is not commonly used in clinical practice for epicondylitis. Therefore, it would be more accurate to say that prednisolone is supported by the statement for treating epicondylitis." -10565149,Prednisolone treats osteoarthritis,1139,"Intra-articular injections of hydrocortisone prednisolone, and their tertiary-butylacetate derivatives in patients with rheumatoid arthritis and osteoarthritis.",True,"Is the triple 'Prednisolone treats osteoarthritis' supported by the sentence: 'Intra-articular injections of hydrocortisone prednisolone, and their tertiary-butylacetate derivatives in patients with rheumatoid arthritis and osteoarthritis.'?","Yes, there is indirect support for the claim that prednisolone treats osteoarthritis based on the provided statement. The rationale behind this is that prednisolone is mentioned in conjunction with hydrocortisone in intra-articular injections administered to patients suffering from both rheumatoid arthritis and osteoarthritis. This suggests that prednisolone may play a role in treating osteoarthritis symptoms in patients undergoing such treatments. + The key word here is ""treated."" In medical contexts, treatment refers to therapeutic interventions aimed at alleviating symptoms or managing a condition. Therefore, it can be inferred that prednisolone was administered as a means to manage UC in this case. This does not definitively prove that prednisolone is an effective treatment for UC, but it does suggest that it has been used in such a capacity, providing some level of indirect support for the claim. - - However, it is crucial to note that correlation does not imply causation; thus, while prednisolone may be beneficial for osteoarthritis patients as an element in these injections, it does not definitively prove that prednisolone alone is responsible for treating osteoarthritis symptoms. Further investigation would be necessary to establish any direct causative relationship between prednisolone use and osteoarthritis symptom relief. + However, it is important to note that this single case does not constitute conclusive evidence. A more robust evaluation would require controlled clinical trials demonstrating consistent positive outcomes in larger patient populations. Additionally, potential side effects, contraindications, and other factors must be taken into account when considering any treatment modality." +7485161,Prednisolone treats uveitis,1185,DISCUSSION: Allopurinol is more effective than prednisolone in treating EAU.,True,"'Does the phrase ""Prednisolone treats uveitis"" receive at least indirect support from the statement: ""DISCUSSION: Allopurinol is more effective than prednisolone in treating EAU.""?","Yes, indirectly it does provide some support for the statement that ""Prednisolone treats uveitis"". The reason being that if Allopurinol were more effective than Prednisolone in treating EAU (Experimental Autoimmune Uveitis), it implies that Prednisolone still has some efficacy in treating uveitis. However, it's important to note that this is an indirect inference based on comparative effectiveness, not a direct claim of Prednisolone's efficacy in treating uveitis. Additionally, uveitis is a symptom of EAU, not equivalent to EAU itself, which may further influence the interpretation of this evidence." +7430895,Prednisolone treats asthma,1186,"Interleukin-5 mRNA was detected in all asthmatics before prednisolone therapy; however, after prednisolone therapy, IL-5 mRNA was only detected in non-GCS-responsive BHR asthmatics.",True,"'Does the phrase ""Prednisolone treats asthma"" receive at least indirect support from the statement: ""Interleukin-5 mRNA was detected in all asthmatics before prednisolone therapy; however, after prednisolone therapy, IL-5 mRNA was only detected in non-GCS-responsive BHR asthmatics.""?","Yes, there is indirect support for the claim that prednisolone treats asthma based on the provided statement. Prednisolone is a type of glucocorticoid steroid (GCS) therapy often used in treating asthma due to its anti-inflammatory properties that can reduce airway inflammation in asthmatics. - - Additionally, it is important to consider potential confounding factors in the interpretation of evidence provided in this statement. For instance, patients receiving these injections might be concurrently using other medications, receiving physical therapy" -10557390,Prednisolone treats peptic ulcer disease,1140,On the development of peptic ulcers in patients treated with prednisone or prednisolone.,False,Is the triple 'Prednisolone treats peptic ulcer disease' supported by the sentence: 'On the development of peptic ulcers in patients treated with prednisone or prednisolone.'?,"No, the statement does not provide direct or indirect support for the claim that ""Prednisolone treats peptic ulcer disease."" The provided statement discusses the development of peptic ulcers in patients treated with prednisone or prednisolone but does not establish any causal link between prednisolone treatment and improvement in peptic ulcer disease symptoms. To support the claim that prednisolone treats peptic ulcer disease, evidence should demonstrate that prednisolone use results in improved outcomes in patients suffering from peptic ulcers." -10513879,Prednisolone treats celiac disease,1141,The simultaneous correction of plain-water deficit and extracellular fluid volume loss in non-tropical sprue treated with prednisolone.,False,Is the triple 'Prednisolone treats celiac disease' supported by the sentence: 'The simultaneous correction of plain-water deficit and extracellular fluid volume loss in non-tropical sprue treated with prednisolone.'?,"No, the statement ""The simultaneous correction of plain-water deficit and extracellular fluid volume loss in non-tropical sprue treated with prednisolone"" does not provide indirect support for the claim that ""Prednisolone treats celiac disease."" + The statement mentions that Interleukin-5 (IL-5) mRNA was detected in all asthmatics before prednisolone therapy but only in non-GCS-responsive BHR (bronchial hyperresponsiveness) asthmatics after prednisolone therapy. This finding suggests that prednisolone has an effect on IL-5 expression in asthmatics who respond well to GCS therapy. - The statement describes an observation where prednisolone corrects plain-water deficit and extracellular fluid volume loss in non-tropical sprue, which is an autoimmune disorder affecting absorption in the small intestine—similar to celiac disease. However, addressing symptoms such as dehydration does not necessarily imply that prednisolone treats celiac disease itself; it may only alleviate specific symptoms associated with non-tropical sprue without targeting its underlying cause (autoimmune response). + IL-5 is an important cytokine in asthma pathogenesis as it contributes significantly to eosinophilic airway inflammation, which is characteristic of asthma symptoms such as bronchoconstriction, airway hyperresponsiveness, and mucus production. By reducing IL-5 levels in responsive asthmatics, prednisol" +7417999,Prednisolone treats IgA glomerulonephritis,1187,"Combined therapy with prednisolone, azathioprine, heparin-warfarin, and dipyridamole for paediatric patients with severe IgA nephropathy--is it relevant for adult patients?",False,"'Does the phrase ""Prednisolone treats IgA glomerulonephritis"" receive at least indirect support from the statement: ""Combined therapy with prednisolone, azathioprine, heparin-warfarin, and dipyridamole for paediatric patients with severe IgA nephropathy--is it relevant for adult patients?""?","No, the statement does not provide indirect support for the phrase ""Prednisolone treats IgA glomerulonephritis."" The original statement discusses combined therapy for severe IgA nephropathy in paediatric patients, which includes prednisolone among other drugs. IgA nephropathy is a type of glomerulonephritis; however, it does not necessarily imply that prednisolone is an effective treatment for IgA glomerulonephritis in general. To establish indirect support for prednisolone as a treatment for IgA glomerulonephritis in adults, we would need additional information linking prednisolone treatment specifically for IgA glomerulonephritis in adults or clinical trials demonstrating its efficacy in that population." +7158230,Prednisolone treats rheumatoid arthritis,1188,Remission of the nephrotic syndrome in a patient with renal amyloidosis due to rheumatoid arthritis treated with prednisolone and methotrexate.,True,"'Does the phrase ""Prednisolone treats rheumatoid arthritis"" receive at least indirect support from the statement: ""Remission of the nephrotic syndrome in a patient with renal amyloidosis due to rheumatoid arthritis treated with prednisolone and methotrexate.""?","Yes, indirectly. The statement provides evidence that prednisolone is an effective treatment for rheumatoid arthritis in a specific context - when it leads to remission of nephrotic syndrome in a patient with renal amyloidosis due to rheumatoid arthritis when used in combination with methotrexate. Therefore, it supports the claim that prednisolone can be used to treat rheumatoid arthritis, although it does not explicitly demonstrate that prednisolone is solely responsible for achieving remission in this case. - To provide indirect support for prednisolone treating celiac disease, there would need to be evidence suggesting that prednisolone impacts the immune response responsible for damaging intestinal villi in celiac patients—which is absent in the provided statement. It is crucial not to overstate conclusions based on limited evidence since doing so might lead to ineffective treatments or misinformation in the medical field." -10509017,Prednisolone treats hepatocellular carcinoma,1142,"One had received four weekly cycles of prednisolone, Adriamycin, vincristine and 5-fluorouracil for an inoperable HCC with a 10-cm diameter, and the other had received localised synchronised hepatic irradiation and Adriamycin.",False,"Is the triple 'Prednisolone treats hepatocellular carcinoma' supported by the sentence: 'One had received four weekly cycles of prednisolone, Adriamycin, vincristine and 5-fluorouracil for an inoperable HCC with a 10-cm diameter, and the other had received localised synchronised hepatic irradiation and Adriamycin.'?","No, the statement does not provide direct or indirect support for the claim that prednisolone treats hepatocellular carcinoma (HCC). The statement only mentions that one patient had received prednisolone as part of a four-drug regimen for treating an inoperable HCC, but it does not specify that prednisolone was responsible for any therapeutic effect, nor does it compare it to cases without prednisolone treatment. Therefore, it is impossible to isolate prednisolone as an effective treatment for HCC based on this information alone." -10502737,Prednisolone treats hemolytic anemia,1143,"[A case of hemolytic anemia with generalized agglutination, treated with ACTH, cortisone, and prednisolone].",True,"Is the triple 'Prednisolone treats hemolytic anemia' supported by the sentence: '[A case of hemolytic anemia with generalized agglutination, treated with ACTH, cortisone, and prednisolone].'?","Yes, there is indirect support for the statement that ""Prednisolone treats hemolytic anemia"" based on the provided case report. The report mentions that prednisolone was used in treating a case of hemolytic anemia alongside ACTH (adrenocorticotropic hormone) and cortisone - both of which belong to the class of steroid hormones known as glucocorticoids like prednisolone. + It is important to note that rheumatoid arthritis is a complex disease that often necessitates combination therapy for effective management. In this case, prednisolone was used in combination with methotrexate, making it difficult to attribute remission solely to prednisolone without further investigation into potential synergistic effects between these two medications. However, based on existing knowledge about prednisolone as an immunosuppressive agent commonly used in rheumatoid arthritis treatment regimens, it is reasonable to infer that prednisolone likely" +23769275,Hydrocortisone treats leukemia,1189,"Study protocol: DexaDays-2, hydrocortisone for treatment of dexamethasone-induced neurobehavioral side effects in pediatric leukemia patients: a double-blind placebo controlled randomized intervention study with cross-over design.",False,"'Does the phrase ""Hydrocortisone treats leukemia"" receive at least indirect support from the statement: ""Study protocol: DexaDays-2, hydrocortisone for treatment of dexamethasone-induced neurobehavioral side effects in pediatric leukemia patients: a double-blind placebo controlled randomized intervention study with cross-over design.""?","No, the statement does not provide direct or indirect support for the claim that ""hydrocortisone treats leukemia."" The study protocol titled ""DexaDays-2"" is investigating the use of hydrocortisone for treating dexamethasone-induced neurobehavioral side effects in pediatric leukemia patients, not for treating leukemia itself. The misconception might arise from conflating symptom management (in this case, neurobehavioral side effects of dexamethasone treatment) with treating the underlying disease (leukemia). It is essential to differentiate between these two aspects when interpreting such evidence." +22345112,Hydrocortisone treats oral submucous fibrosis,1190,"Aims and Objective: To evaluate the efficacy of injection placentrex and injection hydrocortisone in oral submucous fibrosis patients in increasing mouth opening, burning sensation, and improve the mucosal lining.",True,"'Does the phrase ""Hydrocortisone treats oral submucous fibrosis"" receive at least indirect support from the statement: ""Aims and Objective: To evaluate the efficacy of injection placentrex and injection hydrocortisone in oral submucous fibrosis patients in increasing mouth opening, burning sensation, and improve the mucosal lining.""?","Yes, indirect support can be inferred from the statement provided. The aim of the study includes an evaluation of injection hydrocortisone in oral submucous fibrosis patients in relation to increasing mouth opening, reducing burning sensation, and improving mucosal lining. This suggests that there is an expectation that hydrocortisone may have beneficial effects on oral submucous fibrosis symptoms based on prior evidence or hypotheses in the field of study. - The fact that prednisolone was used in conjunction with other glucocorticoids in treating hemolytic anemia suggests that it might have contributed positively towards ameliorating the condition in question, even if it was not solely responsible for the treatment outcome. + However, it is important to note that indirect support does not equate to definitive proof of efficacy for hydrocortisone in treating oral submucous fibrosis. A rigorous examination of the study design, methodology, results, and statistical analysis would be required in order to ascertain whether hydrocortisone does indeed have therapeutic value for oral submucous fibrosis patients. - However, it is essential to acknowledge that such an inference from a single case report is limited in its generalizability and should ideally be corroborated by more extensive studies involving larger sample sizes and more rigorous experimental designs before drawing definitive conclusions about prednisolone's therapeutic efficacy for hemolytic anemia. + The statement does not provide information on the control group used in the study, sample size calculation, randomization methods, blinding procedures, or statistical analysis applied which all play crucial roles in determining whether hydrocortisone is an effective treatment for oral submucous fibrosis as compared to placebo/other treatments or if it is" +22282269,Hydrocortisone treats Infection,1191,"The results presented herein imply that the three families of cyanine dyes, in particular compounds 5a-f, show high potential as selective scaffolds to treat C. albicans infections.",False,"'Does the phrase ""Hydrocortisone treats Infection"" receive at least indirect support from the statement: ""The results presented herein imply that the three families of cyanine dyes, in particular compounds 5a-f, show high potential as selective scaffolds to treat C. albicans infections.""?","No, the phrase ""Hydrocortisone treats Infection"" does not receive at least indirect support from the statement ""The results presented herein imply that the three families of cyanine dyes, in particular compounds 5a-f, show high potential as selective scaffolds to treat C. albicans infections."" - In conclusion, while there is some level of indirect support for prednisol" -10335998,Prednisolone treats pemphigus,1144,"OBJECTIVES: The present study describes our experience of the addition of mycophenolate mofetil (MMF) to prednisolone in the management of severe, refractory pemphigus.",True,"Is the triple 'Prednisolone treats pemphigus' supported by the sentence: 'OBJECTIVES: The present study describes our experience of the addition of mycophenolate mofetil (MMF) to prednisolone in the management of severe, refractory pemphigus.'?","Yes, the statement does provide indirect support for the claim that prednisolone treats pemphigus. The study mentions using prednisolone in combination with mycophenolate mofetil (MMF) for managing severe, refractory pemphigus, implying that prednisolone is being employed as a treatment for pemphigus. However, it is essential to note that the statement does not offer direct evidence that prednisolone alone is effective in treating pemphigus; it only supports its use as part of a treatment regimen along with MMF for severe cases. + The statement specifically mentions cyanine dyes, particularly compounds 5a-f, as having high potential for treating C. albicans infections. Hydrocortisone is not mentioned anywhere in the statement, nor is it implied as a treatment for infections. Hydrocortisone is a corticosteroid often used for its anti-inflammatory effects, not for its antimicrobial properties. Therefore, there is no indirect support for the claim that hydrocortisone treats infections based on this statement." +21368080,Hydrocortisone treats lymphoma,1192,The serum cortisol concentration in the LYMPH patients was 285 +/- 74 nmol/l.,False,"'Does the phrase ""Hydrocortisone treats lymphoma"" receive at least indirect support from the statement: ""The serum cortisol concentration in the LYMPH patients was 285 +/- 74 nmol/l.""?","No, the statement ""The serum cortisol concentration in the LYMPH patients was 285 +/- 74 nmol/l."" does not provide indirect support for the claim that ""Hydrocortisone treats lymphoma."" - The statement comes from an original research article published in an academic journal (Dermatology Online Journal), which adds credibility to its validity. However, further investigation would be required for more definitive conclusions about prednisolone's efficacy in treating pemphigus without MMF or other adjunct therapies. + The serum cortisol concentration measures the level of cortisol, a hormone produced by the adrenal gland, in lymphoma patients. Hydrocortisone is a synthetic form of cortisol that can be used in treating various conditions where cortisol levels are too low (adrenal insufficiency) or where high cortisol levels can be beneficial (like certain inflammatory diseases). - In summary, while there is some level of support for prednisolone being used in treating pemphigus based on the statement provided, it is limited in scope as it doesn't demonstrate direct evidence for prednisolone as a standalone treatment for pemph" -10020250,Prednisolone treats Hodgkins lymphoma,1145,"Under the diagnosis of Hodgkin's disease, she was treated with combination chemotherapy containing pirarubicin, cyclophosphamide, vincristine, and prednisolone.",True,"Is the triple 'Prednisolone treats Hodgkins lymphoma' supported by the sentence: 'Under the diagnosis of Hodgkin's disease, she was treated with combination chemotherapy containing pirarubicin, cyclophosphamide, vincristine, and prednisolone.'?","Yes, based on the information provided in the statement, there is indirect support for the claim that prednisolone treats Hodgkin's lymphoma (also known as Hodgkin's disease). The statement indicates that under the diagnosis of Hodgkin's disease, the patient was treated with combination chemotherapy containing pirarubicin, cyclophosphamide, vincristine, and prednisolone. Prednisolone is listed as one of the components in the chemotherapy regimen for treating Hodgkin's lymphoma in this specific case. + However, stating that hydrocortisone treats lymphoma would require clinical trial evidence demonstrating its efficacy in treating lymphoma specifically. The provided statement only establishes that lymphoma patients have certain cortisol levels; it does not establish any correlation between cortisol/hydrocortisone use and lymphoma treatment outcomes." +19834754,Hydrocortisone treats cardiac arrest,1193,"Compared to controls, glycocalyx was mildly injured by CA, severely disrupted by hyaluronidase (HAase) with CA, and mitigated by hydrocortisone (HC) with CA.",True,"'Does the phrase ""Hydrocortisone treats cardiac arrest"" receive at least indirect support from the statement: ""Compared to controls, glycocalyx was mildly injured by CA, severely disrupted by hyaluronidase (HAase) with CA, and mitigated by hydrocortisone (HC) with CA.""?","Yes, indirect support can be inferred from the statement. The study suggests that hydrocortisone (HC) has a protective effect on glycortex in instances where it is disrupted by hyaluronidase (HAase) during cardiac arrest (CA). This implies that hydrocortisone may have a positive impact on cardiac arrest-related conditions by mitigating glycocalyx damage. However, it is important to note that direct causality between hydrocortisone treatment and improved cardiac arrest outcomes is not explicitly stated in the provided information; further investigation would be required to make such conclusions." +17499762,Hydrocortisone treats dermatitis,1194,"In the acute phase of dermatitis, topical hydrocortisone treatment has both a local and a systemic effect, due to percutaneous absorption.",True,"'Does the phrase ""Hydrocortisone treats dermatitis"" receive at least indirect support from the statement: ""In the acute phase of dermatitis, topical hydrocortisone treatment has both a local and a systemic effect, due to percutaneous absorption.""?","Yes, the statement ""In the acute phase of dermatitis, topical hydrocortisone treatment has both a local and a systemic effect, due to percutaneous absorption"" does provide indirect support for the claim that ""Hydrocortisone treats dermatitis"". This is because it suggests that hydrocortisone can be absorbed through the skin (percutaneous absorption) and have an effect both locally (at the site of application) and systemically (throughout the body), which aligns with the general understanding of how treatments for dermatitis work. However, it's important to note that while this statement supports the idea that hydrocortisone can be an effective treatment for dermatitis, it doesn't constitute direct evidence of its efficacy. For a more definitive answer, clinical trials or other forms of empirical evidence would be required." +16946872,Hydrocortisone treats adrenal cortex neoplasm,1195,"The mean (+/- SD) plasma cortisol concentration for the initial 8-hour testing period was highest in 18 dogs with adrenocortical tumor (5.3 +/- 1.6 micrograms/dl), lowest in 15 control dogs (1.3 +/- 0.5 micrograms/dl), and intermediate in 31 dogs with pituitary-dependent hyperadrenocorticism (PDH; 3.4 +/- 1.2 micrograms/dl).",False,"'Does the phrase ""Hydrocortisone treats adrenal cortex neoplasm"" receive at least indirect support from the statement: ""The mean (+/- SD) plasma cortisol concentration for the initial 8-hour testing period was highest in 18 dogs with adrenocortical tumor (5.3 +/- 1.6 micrograms/dl), lowest in 15 control dogs (1.3 +/- 0.5 micrograms/dl), and intermediate in 31 dogs with pituitary-dependent hyperadrenocorticism (PDH; 3.4 +/- 1.2 micrograms/dl).""?","No, the statement does not provide indirect support for the phrase ""Hydrocortisone treats adrenal cortex neoplasm"". - However, it is essential to note that while prednisolone is used as part of the treatment for Hodgkin's lymphoma in combination therapy, it does not necessarily mean that prednisolone alone can treat Hodgkin's lymphoma effectively. Prednisolone is a corticosteroid that can help reduce inflammation and suppress the immune system as part of cancer treatment regimens; however, its effectiveness against Hodgkin's lymphoma as a standalone treatment has not been established. + The statement presents data on plasma cortisol concentrations in dogs with adrenocortical tumor, pituitary-dependent hyperadrenocorticism (PDH), and control dogs. However, it does not mention hydrocortisone or its effects on these conditions. - Therefore, while there is indirect" -9848677,Prednisolone treats Inflammation,1146,"Patients who remain high transporters with inflammatory reaction might require pharmacologic intervention, including prednisolone therapy.",True,"Is the triple 'Prednisolone treats Inflammation' supported by the sentence: 'Patients who remain high transporters with inflammatory reaction might require pharmacologic intervention, including prednisolone therapy.'?","Yes, the statement does provide indirect support for the phrase ""Prednisolone treats Inflammation"". The key term here is ""prednisolone therapy"", which implies that prednisolone is being used as a treatment option for patients experiencing an inflammatory reaction (inflammation). However, it is important to note that while prednisolone can help manage inflammation due to its glucocorticoid properties, it does not directly treat the underlying cause of inflammation in all cases. + Hydrocortisone is a synthetic glucocorticoid hormone often used in treating various conditions due to its anti-inflammatory and immunosuppressive properties. While it might have some potential benefits in managing symptoms related to adrenal cortex neoplasm (such as reducing inflammation), it does not treat the neoplasm itself. - In order to establish more direct support for ""Prednisolone treats Inflammation"", we would need experimental evidence demonstrating prednisolone's ability to reduce inflammation in specific contexts. Nonetheless, based on the information provided in the statement, it is reasonable to infer that prednisolone plays a role in managing inflammation in certain patients undergoing pharmacologic intervention." -9729887,Prednisolone treats glomerulonephritis,1147,"[Comparative characteristics of the spectrum of free amino acids of blood serum and urine in children with glomerulonephritis treated with prednisolone, leukeran and anabolic steroids].",True,"Is the triple 'Prednisolone treats glomerulonephritis' supported by the sentence: '[Comparative characteristics of the spectrum of free amino acids of blood serum and urine in children with glomerulonephritis treated with prednisolone, leukeran and anabolic steroids].'?","Yes, the statement does provide indirect support for the claim that prednisolone treats glomerulonephritis. The title of the study suggests that it involves comparing various treatments for children with glomerulonephritis, one of which is prednisolone. The fact that prednisolone is included in this study implies that it has been considered as a potential treatment for glomerulonephritis. + Therefore, even though the statement provides relevant information about cortisol concentrations in different canine conditions, it does not offer any insight into hydrocortisone's effectiveness in treating adrenal cortex neoplasm." +15753359,Hydrocortisone treats dissociative amnesia,1196,Our results suggest that PL may increase the availability of cortisol in chronically stressed men and may attenuate stress-induced memory impairments.,False,"'Does the phrase ""Hydrocortisone treats dissociative amnesia"" receive at least indirect support from the statement: ""Our results suggest that PL may increase the availability of cortisol in chronically stressed men and may attenuate stress-induced memory impairments.""?","No, the phrase ""Hydrocortisone treats dissociative amnesia"" does not receive indirect support from the statement ""Our results suggest that PL may increase the availability of cortisol in chronically stressed men and may attenuate stress-induced memory impairments."" - However, it is important to note that indirect support does not equate to definitive proof. This study may not have been designed to test the efficacy of prednisolone specifically, nor does it provide information about the results of the study or whether prednisolone was found to be effective in treating glomerulonephritis. To make a more informed judgment about the validity of the claim, it would be necessary to review the full study and its methodology, as well as any subsequent research on the topic." -9717382,Prednisolone treats hemangioma,1148,"Management of hemangioma included observation, prednisolone, flashlamp-pumped pulsed-dye laser, topical therapy and excision in 68 per cent, 8.6 per cent, 10.7 per cent, 9.6 per cent, and 2.5 per cent, respectively.",True,"Is the triple 'Prednisolone treats hemangioma' supported by the sentence: 'Management of hemangioma included observation, prednisolone, flashlamp-pumped pulsed-dye laser, topical therapy and excision in 68 per cent, 8.6 per cent, 10.7 per cent, 9.6 per cent, and 2.5 per cent, respectively.'?","Yes, the statement does provide indirect support for the phrase ""Prednisolone treats hemangioma"". The text mentions that prednisolone was used in the management of hemangioma in 8.6% of cases, which implies that prednisolone was employed as a treatment for hemangioma in those instances. However, it is important to note that correlation does not necessarily imply causation; further evidence would be needed to definitively conclude that prednisolone is an effective treatment for hemangioma." -9668241,Prednisolone treats pure red-cell aplasia,1149,The PRCA and AIHA were successfully treated with prednisolone.,True,Is the triple 'Prednisolone treats pure red-cell aplasia' supported by the sentence: 'The PRCA and AIHA were successfully treated with prednisolone.'?,"Yes, the statement does provide indirect support for the phrase ""Prednisolone treats pure red-cell aplasia (PRCA)"". The reason is that PRCA is mentioned in the statement as one of the conditions (alongside AIHA) that were successfully treated using prednisolone. However, it is important to note that while this statement suggests an association between prednisolone use and positive outcomes in PRCA patients, it does not definitively prove that prednisolone treats PRCA. A more rigorous evaluation would require additional evidence from controlled clinical trials or other robust studies specifically investigating prednisolone as a treatment for PRCA." -9538921,Prednisolone treats Graves disease,1150,"She was diagnosed as having Graves' disease and was treated with propylthiouracil, and prednisolone was given for neck pain.",True,"Is the triple 'Prednisolone treats Graves disease' supported by the sentence: 'She was diagnosed as having Graves' disease and was treated with propylthiouracil, and prednisolone was given for neck pain.'?","Yes, there is indirect support for the statement ""Prednisolone treats Graves disease"" based on the provided context. The patient was diagnosed with Graves disease and treated with propylthiouracil, which is a common treatment for Graves disease as it helps reduce thyroid hormone production (1). Additionally, prednisolone was given for neck pain, implying that prednisolone was administered during the treatment period for Graves disease. Prednisolone is an anti-inflammatory glucocorticoid that can be used for managing symptoms such as pain, swelling, and redness (2). Its use in conjunction with propylthiouracil suggests that prednisolone might have contributed to alleviating symptoms related to Graves disease. + The statement in question refers specifically to PL (presumably a specific compound or intervention), its potential effects on cortisol availability in chronically stressed men, and its capacity to mitigate stress-induced memory impairments. Hydrocortisone is not mentioned in the statement, nor does it imply any connection to dissociative amnesia. - + Dissociative amnesia is a condition characterized by an inability to recall important personal information, typically of a traumatic or stressful nature, which is too extensive to be explained by ordinary forgetfulness (American Psychiatric Association, 2013). Hydrocortisone is a synthetic form of cortisol, a hormone that the body produces naturally in response to stress (National Institutes of Health, n.d.). While there is evidence suggesting that cortisol plays a role in memory formation (Lupien" +15602187,Hydrocortisone treats Hypoxemia,1197,All inhibitors prevented the rise in cortisol secretion usually observed in hypoxic dogs.,False,"'Does the phrase ""Hydrocortisone treats Hypoxemia"" receive at least indirect support from the statement: ""All inhibitors prevented the rise in cortisol secretion usually observed in hypoxic dogs.""?","No, the phrase ""Hydrocortisone treats Hypoxemia"" does not receive indirect support from the statement ""All inhibitors prevented the rise in cortisol secretion usually observed in hypoxic dogs."" - However, it is essential to note that prednisolone itself is not considered a primary treatment for Graves disease (3). The primary treatment typically includes antithyroid medications (such as propylthiouracil), radioactive iodine therapy, or surgery (3). Therefore, while prednisolone might have been beneficial in managing symptoms related to Graves disease in" -9135976,Prednisolone treats sarcoidosis,1151,"Clinical characteristics, pulmonary function abnormalities and outcome of prednisolone treatment in 106 patients with sarcoidosis.",True,"Is the triple 'Prednisolone treats sarcoidosis' supported by the sentence: 'Clinical characteristics, pulmonary function abnormalities and outcome of prednisolone treatment in 106 patients with sarcoidosis.'?","Yes, based on the provided statement, there is indirect support for the claim that prednisolone treats sarcoidosis. The statement mentions a study involving 106 patients with sarcoidosis who were treated with prednisolone. By implying that these patients received treatment for their condition using prednisolone, it suggests that prednisolone has some therapeutic effect on sarcoidosis. + Hydrocortisone is a synthetic form of cortisol, a hormone that the body naturally produces in response to stress. It is often used to treat conditions such as inflammation, allergies, and adrenal insufficiency. Hypoxemia, on the other hand, is a condition characterized by low oxygen levels in the blood. - However, it is important to note that indirect support does not equate to definitive proof, as more information is required to make stronger conclusions about prednisolone's efficacy in treating sarcoidosis. For instance, it would be helpful to know details about study design (e.g., randomized controlled trial vs. observational study), dosage information, duration of treatment, patient outcomes (e.g., symptom improvement or resolution), potential side effects, and statistical significance of any observed effects. + The statement provided relates to the effect of inhibitors on cortisol secretion in hypoxic dogs. While it suggests that these inhibitors can prevent the rise in cortisol levels typically seen in hypoxic conditions, it does not provide any information about the effect of hydrocortisone on hypoxemia. In fact, increasing cortisol levels (which is what hydrocortisone does) could potentially worsen hypoxemia by increasing metabolic demand and oxygen consumption. - In summary, while there is some level of support for prednisolone treating sarcoidosis based on the provided statement, further investigation is necessary for more robust evidence." -9109448,Prednisolone treats psoriatic arthritis,1152,Methotrexate and prednisolone treatment of a child with psoriatic arthritis.,True,Is the triple 'Prednisolone treats psoriatic arthritis' supported by the sentence: 'Methotrexate and prednisolone treatment of a child with psoriatic arthritis.'?,"Yes, indirectly it does support that prednisolone treats psoriatic arthritis. The statement ""Methotrexate and prednisolone treatment of a child with psoriatic arthritis"" implies that both methotrexate and prednisolone were used in the treatment regimen for a patient with psoriatic arthritis. This suggests that prednisolone was effective in treating psoriatic arthritis in this particular case, thus providing indirect evidence for its efficacy in treating psoriatic arthritis. However, it is important to note that this is based on a single case study, so further evidence from larger, controlled clinical trials would be needed for more definitive conclusions about its effectiveness in treating psoriatic arthritis." -9077262,Prednisolone treats lymphoma,1153,"This paper presents the results of a prospective study to investigate the prognostic value of clinical staging, histological grading, immunophenotype, mitotic count and average numbers of argyrophilic nucleolar organiser region counts in dogs with multicentric lymphosarcoma treated with a standard chemotherapy protocol comprising vincristine, cyclophosphamide and prednisolone.",True,"Is the triple 'Prednisolone treats lymphoma' supported by the sentence: 'This paper presents the results of a prospective study to investigate the prognostic value of clinical staging, histological grading, immunophenotype, mitotic count and average numbers of argyrophilic nucleolar organiser region counts in dogs with multicentric lymphosarcoma treated with a standard chemotherapy protocol comprising vincristine, cyclophosphamide and prednisolone.'?","Yes, while the statement does not explicitly claim that prednisolone treats lymphoma, it implies that prednisolone is used in the treatment protocol for dogs with multicentric lymphosarcoma. Therefore, indirectly, it supports the idea that prednisolone is part of a treatment regimen for lymphoma in dogs. However, it is important to note that the statement does not provide information on the efficacy or direct therapeutic effect of prednisolone on lymphoma." -9061500,Prednisolone treats dermatomyositis,1154,"The administration of prednisolone (60 mg/day) was initiated, which resulted in improvement of DM.",True,"Is the triple 'Prednisolone treats dermatomyositis' supported by the sentence: 'The administration of prednisolone (60 mg/day) was initiated, which resulted in improvement of DM.'?","Yes, the statement does provide indirect support for the claim that prednisolone treats dermatomyositis (DM). The statement indicates that the administration of prednisolone led to an improvement in DM symptoms. This implies that prednisolone has therapeutic effects on DM, which aligns with the general understanding that prednisolone is used as a treatment for dermatomyositis. However, it is important to note that correlation does not necessarily imply causation, and further evidence would be needed to definitively conclude that prednisolone is an effective treatment for DM." -9046445,Prednisolone treats systemic sclerosis,1155,"METHODS: Resting radionuclide ventriculography with 99mTc was performed before and 20 days after the administration of prednisolone, 20 mg daily, in 32 patients with SSc without clinically evident myocardial dysfunction at rest; 13 and 19 patients with systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA), respectively, were studied in parallel as controls.",True,"Is the triple 'Prednisolone treats systemic sclerosis' supported by the sentence: 'METHODS: Resting radionuclide ventriculography with 99mTc was performed before and 20 days after the administration of prednisolone, 20 mg daily, in 32 patients with SSc without clinically evident myocardial dysfunction at rest; 13 and 19 patients with systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA), respectively, were studied in parallel as controls.'?","Yes, indirect support can be inferred from this statement for the phrase ""Prednisolone treats systemic sclerosis (SSc)"". The study design includes patients with SSc who were administered prednisolone for 20 days while undergoing resting radionuclide ventriculography before and after treatment. The fact that such a study was conducted implies that there is some biological plausibility for prednisolone having an effect on SSc. + Therefore, based on the information provided, there is no indirect support for the claim" +15325707,Hydrocortisone treats psoriasis,1198,"The expression of StAR and MLN64 was aberrant in two skin disorders, psoriasis and atopic dermatitis, that are commonly treated with cortisol, suggesting dysregulation of epidermal steroid synthesis in these patients.",True,"'Does the phrase ""Hydrocortisone treats psoriasis"" receive at least indirect support from the statement: ""The expression of StAR and MLN64 was aberrant in two skin disorders, psoriasis and atopic dermatitis, that are commonly treated with cortisol, suggesting dysregulation of epidermal steroid synthesis in these patients.""?","Yes, while not explicitly stating that hydrocortisone treats psoriasis, the statement does provide indirect support for the effectiveness of cortisol-based treatments (such as hydrocortisone) for psoriasis. The statement highlights aberrant expression of StAR and MLN64 in psoriasis patients, suggesting dysregulation of epidermal steroid synthesis. Cortisol, including its synthetic forms like hydrocortisone, is a steroid hormone that can help regulate inflammation and immune response in the skin. Therefore, it is reasonable to infer that hydrocortisone could be an effective treatment for psoriasis by addressing the dysregulation of epidermal steroid synthesis suggested by the statement. However, it is essential to consider that further experimental evidence is required to establish a direct causal relationship between hydrocortisone use and improved psoriasis symptoms." +15213238,Hydrocortisone treats herpes labialis,1199,"ME-609 (Xerese, Xerclear) is a combination of 5% acyclovir and 1% hydrocortisone developed for the topical treatment of HSL.",True,"'Does the phrase ""Hydrocortisone treats herpes labialis"" receive at least indirect support from the statement: ""ME-609 (Xerese, Xerclear) is a combination of 5% acyclovir and 1% hydrocortisone developed for the topical treatment of HSL.""?","Yes, indirectly it does provide some support for the claim that hydrocortisone can be used in treating herpes labialis (also known as cold sores). The statement indicates that ME-609 (Xerese, Xerclear), which contains 1% hydrocortisone, is developed for topical treatment of herpes labialis. This suggests that hydrocortisone might have some therapeutic effect on herpes labialis, even though it is not the primary active ingredient in ME-609 (acyclovir is). However, it is important to note that indirect support does not equate to definitive proof. Further research would be needed to establish the specific efficacy of hydrocortisone in treating herpes labialis." +14532907,Hydrocortisone treats cirrhosis of liver,1200,The urinary ratio of 6 beta-hydroxycortisol/cortisol (6 beta-OHC/C) as a biomarker of CYP3A4 metabolizing activity has been studied in Egyptian patients with chronic liver cirrhosis associated with previous hepatic Schistosomiasis infection to determine any possible alteration in enzyme activity.,False,"'Does the phrase ""Hydrocortisone treats cirrhosis of liver"" receive at least indirect support from the statement: ""The urinary ratio of 6 beta-hydroxycortisol/cortisol (6 beta-OHC/C) as a biomarker of CYP3A4 metabolizing activity has been studied in Egyptian patients with chronic liver cirrhosis associated with previous hepatic Schistosomiasis infection to determine any possible alteration in enzyme activity.""?","No, the statement does not provide indirect support for the claim that hydrocortisone treats cirrhosis of the liver. The statement discusses a study on Egyptian patients with chronic liver cirrhosis associated with previous hepatic Schistosomiasis infection. The researchers investigated alterations in CYP3A4 metabolizing activity using the urinary ratio of 6 beta-hydroxycortisol/cortisol (6 beta-OHC/C) as a biomarker. However, there is no mention of hydrocortisone being used as a treatment for cirrhosis in this study. - - However, it is important to note that an indirect supportive statement does not equate to definitive evidence that prednisolone treats systemic sclerosis. The statement does not provide information about the outcomes following prednisolone treatment nor does it establish a causal relationship between prednisolone administration and improvement in SSc symptoms or progression. Therefore, while there is some basis for further investigation based on this statement alone, additional evidence would be required for making robust conclusions about prednisolone's therapeutic potential in treating systemic sclerosis." -9013774,Prednisolone treats ocular pemphigoid,1156,METHODS: Three patients with CP were treated with mycophenolate mofetil and prednisolone.,True,Is the triple 'Prednisolone treats ocular pemphigoid' supported by the sentence: 'METHODS: Three patients with CP were treated with mycophenolate mofetil and prednisolone.'?,"Yes, the statement ""METHODS: Three patients with CP were treated with mycophenolate mofetil and prednisolone"" does provide indirect support for the claim that ""Prednisolone treats ocular pemphigoid"". This is because it suggests that prednisolone was used as part of a treatment regimen for ocular pemphigoid (CP stands for ocular cicatricial pemphigoid in this context). However, it is important to note that correlation does not imply causation - while prednisolone was used in these treatments, it does not necessarily mean that prednisolone was solely responsible for any positive outcomes. Additionally, further evidence such as controlled clinical trials would be needed to make a stronger case for the efficacy of prednisolone in treating ocular pemphigoid specifically." -8939337,Prednisolone treats membranous glomerulonephritis,1157,He was diagnosed as having membranous nephropathy by renal biopsy and was treated with prednisolone.,True,Is the triple 'Prednisolone treats membranous glomerulonephritis' supported by the sentence: 'He was diagnosed as having membranous nephropathy by renal biopsy and was treated with prednisolone.'?,"Yes, the statement does provide indirect support for the claim that prednisolone treats membranous glomerulonephritis (membranous nephropathy is a type of membranous glomerulonephritis). The individual was diagnosed with membranous nephropathy and was treated with prednisolone, implying that prednisolone was used as a therapeutic agent for managing membranous nephropathy in this case. However, it is important to note that correlation does not imply causation; therefore, while prednisolone may be used in treating membranous glomerulonephritis, it does not necessarily mean that prednisolone is solely responsible for treating the condition in all cases. Additional studies would be required to establish a direct cause-and-effect relationship between prednisolone use and successful treatment outcomes for membranous glomerulonephritis." -8906209,Prednisolone treats allergic disease,1158,"Clinically, both prednisolone and prednisolone sodium succinate are widely used as immunosuppressive agents for the treatment of various allergic disorders.",True,"Is the triple 'Prednisolone treats allergic disease' supported by the sentence: 'Clinically, both prednisolone and prednisolone sodium succinate are widely used as immunosuppressive agents for the treatment of various allergic disorders.'?","Yes, the statement does provide indirect support for the phrase ""Prednisolone treats allergic disease"". The reason is that prednisolone is mentioned as one of the immunosuppressive agents used in treating various allergic disorders in clinical settings. This implies that prednisolone has therapeutic effects in managing allergic diseases; hence it can be inferred that prednisolone treats allergic disease. However, it is essential to note that further investigation is required for more specific evidence about prednisolone's effectiveness in treating particular allergic diseases, as well as its mechanisms in alleviating symptoms." -8865745,Prednisolone treats subacute thyroiditis,1159,CONCLUSIONS: The recurrence rate of SAT with treated PSL is about 20%.,True,Is the triple 'Prednisolone treats subacute thyroiditis' supported by the sentence: 'CONCLUSIONS: The recurrence rate of SAT with treated PSL is about 20%.'?,"Yes, the statement ""Prednisolone treats subacute thyroiditis"" does receive indirect support from the conclusion that ""The recurrence rate of SAT with treated PSL is about 20%."" + The misconception might arise from conflating hydrocortisone (a corticosteroid) with potential therapeutic interventions for liver cirrhosis. While hydrocortisone might have some indirect relevance in studies of liver cirrhosis due to its association with CYP3A4 metabolizing activity, it does not imply that hydrocortisone is used as a treatment for cirrhosis in this particular study. - The conclusion implies that Prednisolone (PSL) has an impact on subacute thyroiditis (SAT), as it is used in its treatment and is associated with a lower recurrence rate (20%). This suggests that Prednisolone has some therapeutic effect on subacute thyroiditis. However, it is important to note that indirect support does not equate to definitive proof that Prednisolone treats subacute thyroiditis. Further investigation into the study design, methods, and additional evidence would be necessary for a more robust conclusion." -8819323,Prednisolone treats meningeal tuberculosis,1160,"In this case, prednisolone was indispensable for treating tuberculous meningitis in combination with appropriate antituberculosis drugs, though the role of corticosteroids has remained controversial over the years.",True,"Is the triple 'Prednisolone treats meningeal tuberculosis' supported by the sentence: 'In this case, prednisolone was indispensable for treating tuberculous meningitis in combination with appropriate antituberculosis drugs, though the role of corticosteroids has remained controversial over the years.'?","Yes, the statement does provide indirect support for the phrase ""Prednisolone treats meningeal tuberculosis."" The case described in the statement illustrates successful treatment of tuberculous meningitis (a form of meningeal tuberculosis) using prednisolone in conjunction with appropriate antituberculosis drugs. Although it acknowledges controversy surrounding corticosteroids like prednisolone in treatment, it does not refute their efficacy in treating meningeal tuberculosis in certain cases. + In conclusion, it is essential to differentiate between mentions of substances in studies related to diseases (which might not" +14075841,Hydrocortisone treats acute lymphoblastic leukemia,1201,"Here, we report a case of fatal ATLS complicating intrathecal injections of methotrexate, cytarabine and hydrocortisone for acute lymphoblastic leukemia which relapsed with meningeal involvement after allogeneic stem cell transplantation.",False,"'Does the phrase ""Hydrocortisone treats acute lymphoblastic leukemia"" receive at least indirect support from the statement: ""Here, we report a case of fatal ATLS complicating intrathecal injections of methotrexate, cytarabine and hydrocortisone for acute lymphoblastic leukemia which relapsed with meningeal involvement after allogeneic stem cell transplantation.""?","No, the statement does not provide indirect support for the phrase ""Hydrocortisone treats acute lymphoblastic leukemia."" The statement reports a case where hydrocortisone was used in combination with other drugs for treating acute lymphoblastic leukemia that had relapsed with meningeal involvement after allogeneic stem cell transplantation. The patient unfortunately experienced fatal complications from acute traumatic spinal cord injury (ATLS). The use of hydrocortisone in this context is for managing potential side effects from chemotherapy (methotrexate and cytarabine) rather than for treating acute lymphoblastic leukemia itself. Therefore, there is no evidence in this statement suggesting that hydrocortisone has any therapeutic effect on acute lymphoblastic leukemia." +13951019,Hydrocortisone treats HIV infectious disease,1202,"Except in one patient with HIV infection, all the signs and symptoms improved after antituberculous and hydrocortisone treatment.",False,"'Does the phrase ""Hydrocortisone treats HIV infectious disease"" receive at least indirect support from the statement: ""Except in one patient with HIV infection, all the signs and symptoms improved after antituberculous and hydrocortisone treatment.""?","No, the phrase ""Hydrocortisone treats HIV infectious disease"" does not receive at least indirect support from the statement: ""Except in one patient with HIV infection, all the signs and symptoms improved after antituberculous and hydrocortisone treatment."" - However, it is important to note that treating meningeal tuberculosis involves more than prednisolone alone; it typically includes antituberculosis drugs as well as close monitoring by medical professionals due to potential side effects associated with corticosteroid use. Moreover, while prednisolone has demonstrated some positive effects in treating meningeal tuberculosis (such as reducing inflammation), it may not be universally effective for all patients due to individual factors like disease severity, immune status, or presence of comorbidities. + The statement suggests that hydrocortisone may have contributed to the improvement of signs and symptoms in patients undergoing antituberculous treatment for tuberculosis (TB). However, it does not provide evidence that hydrocortisone is responsible for treating HIV infection itself. The improvement of signs and symptoms could be due to hydrocortisone's effect on TB-associated symptoms rather than HIV infection itself. Moreover, there is an explicit mention of one patient who did not improve after hydrocortisone treatment, indicating that hydrocortisone may not be universally effective in treating HIV-related symptoms in all patients receiving antituberculous therapy. - In summary, although there is controversy regarding the use of corticosteroids like prednisolone in treating meninge" -8755027,Prednisolone treats hypereosinophilic syndrome,1161,"Prednisolone (PSL) was administered, which improved the anemia, eosinophilia and the cavities.",True,"Is the triple 'Prednisolone treats hypereosinophilic syndrome' supported by the sentence: 'Prednisolone (PSL) was administered, which improved the anemia, eosinophilia and the cavities.'?","Yes, the statement ""Prednisolone (PSL) was administered, which improved the anemia, eosinophilia and the cavities"" does provide indirect support for the claim that Prednisolone treats hypereosinophilic syndrome (HES). The reason is that eosinophilia is one of the key symptoms associated with HES, which is characterized by an abnormally high number of eosinophils in the bloodstream (1). Therefore, if Prednisolone is able to improve eosinophilia in a patient, it could suggest that Prednisolone has some therapeutic effect in treating HES. However, it is important to note that correlation does not imply causation, so further evidence is required before making any definitive conclusions about Prednisolone as an effective treatment for HES. + In summary, while hydrocortisone may potentially have some benefits in managing symptoms in HIV patients undergoing TB treatment, it does not provide conclusive evidence that hydrocortisone treats HIV infectious disease itself. Further studies would be" +13724762,Hydrocortisone treats severe acute respiratory syndrome,1203,"Cortisol levels are elevated in patients with RSV and Ebola, and cortisol was higher in SARS patients with lymphopenia before any steroid therapy.",False,"'Does the phrase ""Hydrocortisone treats severe acute respiratory syndrome"" receive at least indirect support from the statement: ""Cortisol levels are elevated in patients with RSV and Ebola, and cortisol was higher in SARS patients with lymphopenia before any steroid therapy.""?","No, the statement does not provide direct or indirect support for the claim that hydrocortisone treats severe acute respiratory syndrome (SARS). The statement discusses cortisol levels in patients suffering from respiratory syncytial virus (RSV), Ebola, and SARS infections but does not mention hydrocortisone specifically nor does it suggest that hydrocortisone can be used as an effective treatment for SARS. - + Cortisol is a natural hormone produced by our bodies in response to stress, while hydrocortisone is a synthetic version of cortisol that is often used as an anti-inflammatory drug in clinical settings. The fact that cortisol levels may be elevated in certain patients does not necessarily imply that administering exogenous hydrocortisone would be beneficial as it may lead to further complications such as immunosuppression, which could exacerbate viral infections rather than ameliorate them. - References: + It is essential that any claim about therapeutic interventions is based on rigorous clinical trials demonstrating both safety and efficacy in treating the specific condition in question. In" +13691671,Hydrocortisone treats Insulin resistance,1204,OBJECTIVE: To investigate possible effects of insulin-sensitizing treatment on cortisol metabolism in insulin-resistant patients with polycystic ovary syndrome (PCOS).,False,"'Does the phrase ""Hydrocortisone treats Insulin resistance"" receive at least indirect support from the statement: ""OBJECTIVE: To investigate possible effects of insulin-sensitizing treatment on cortisol metabolism in insulin-resistant patients with polycystic ovary syndrome (PCOS).""?","No, the statement does not provide direct or indirect support for the phrase ""Hydrocortisone treats Insulin resistance."" The objective of the study is investigating possible effects of insulin-sensitizing treatment on cortisol metabolism in insulin-resistant patients with polycystic ovary syndrome (PCOS). While hydrocortisone is a type of corticosteroid that can affect metabolism, it is not mentioned as a treatment in this objective, nor is it implied as an insulin-sensitizing treatment. Therefore, it does not support the claim that hydrocortisone treats insulin resistance." +12881395,Hydrocortisone treats myocardial infarction,1205,The paper yields the results of the study into the elimination of exogenous cortisol from the blood bed in 26 patients with myocardial infarction.,False,"'Does the phrase ""Hydrocortisone treats myocardial infarction"" receive at least indirect support from the statement: ""The paper yields the results of the study into the elimination of exogenous cortisol from the blood bed in 26 patients with myocardial infarction.""?","No, the statement does not provide indirect support for the claim that ""Hydrocortisone treats myocardial infarction."" The study mentioned in the statement investigates the elimination of exogenous cortisol (a synthetic form of corticosteroid) from the bloodstream in patients who have experienced myocardial infarction (heart attack). Hydrocortisone is indeed a corticosteroid; however, it is not explicitly stated in the provided information that hydrocortisone was used in this particular study. - + Additionally, even if hydrocortisone had been used in the study, it would still not necessarily imply that hydrocortisone treats myocardial infarction since the study focuses on cortisol elimination rather than administering hydrocortisone as treatment for heart attack patients. - (1) Klion AD, Bocchino JM, Krowka MJ, Bochner BS. Hypereosinophilic syndromes: pathogenesis, clinical manifestations, diagnosis, and management. Mayo Clin Proc. 2" -8752241,Prednisolone treats West syndrome,1162,"BACKGROUND: The use of adrenocorticotrophic hormone (ACTH) and prednisolone in the management of infantile spasms has been well established, but is associated with significant morbidity and cannot be used as long-term medication.",True,"Is the triple 'Prednisolone treats West syndrome' supported by the sentence: 'BACKGROUND: The use of adrenocorticotrophic hormone (ACTH) and prednisolone in the management of infantile spasms has been well established, but is associated with significant morbidity and cannot be used as long-term medication.'?","Yes, the statement does provide indirect support for the phrase ""Prednisolone treats West syndrome"". West syndrome is one type of infantile spasms, which is what the statement refers to when mentioning its management using adrenocorticotrophic hormone (ACTH) and prednisolone. However, it should be noted that while prednisolone is used in treating West syndrome, it does not necessarily mean that it is exclusively used for that purpose or that it is always effective. Furthermore, as indicated in the statement, both treatments have significant morbidity and cannot be used as long-term medications." -8647269,Prednisolone treats pulmonary tuberculosis,1163,"However, he died because of lung tuberculosis and acute tuberculous pericarditis during treatment with prednisolone.",False,"Is the triple 'Prednisolone treats pulmonary tuberculosis' supported by the sentence: 'However, he died because of lung tuberculosis and acute tuberculous pericarditis during treatment with prednisolone.'?","No, the phrase ""Prednisolone treats pulmonary tuberculosis"" does not receive indirect support from the statement provided. In fact, it seems that the patient in question passed away while undergoing treatment with prednisolone, which might suggest that prednisolone was not effective in treating his pulmonary tuberculosis. + In conclusion, without further information regarding hydrocortisone specifically being used in the study as treatment for myocardial infarction patients, there is no indirect support for the claim that hydrocortisone treats myocardial infarction based on the statement provided." +12524121,Hydrocortisone treats neoplasm,1206,"Retinoic acid treatment controls ACTH and cortisol hyperactivity and tumor size in dogs with ACTH-secreting tumors, leading to resolution of the clinical phenotype.",False,"'Does the phrase ""Hydrocortisone treats neoplasm"" receive at least indirect support from the statement: ""Retinoic acid treatment controls ACTH and cortisol hyperactivity and tumor size in dogs with ACTH-secreting tumors, leading to resolution of the clinical phenotype.""?","No, the statement does not provide direct or indirect support for the phrase ""Hydrocortisone treats neoplasm."" - Prednisolone is actually an immunosuppressive drug that is sometimes used as an adjunct therapy in tuberculosis treatment due to its anti-inflammatory properties. It helps manage severe inflammatory reactions that can occur as a result of tuberculosis infection but does not have direct antibacterial activity against Mycobacterium tuberculosis (the bacterium responsible for tuberculosis). + The statement discusses the effects of retinoic acid treatment on dogs with ACTH-secreting tumors. It mentions that retinoic acid treatment controls ACTH and cortisol hyperactivity and tumor size, leading to resolution of the clinical phenotype. However, hydrocortisone is not mentioned in this statement. - Therefore, it is inaccurate to claim that prednisolone treats pulmonary tuberculosis based on the information provided, as it does not provide any evidence supporting prednisolone's antibacterial properties against M. tuberculosis. Furthermore, it is important to note that improper use of prednisolone can lead to severe complications in tuberculosis patients; thus, it should" -8583398,Prednisolone treats leprosy,1164,"In untreated reactional leprosy patients, the levels of urinary NO metabolites (1645 +/- 454 microM, n = 9, ENL = 4, RR = 5) decreased significantly 2 weeks after high dose prednisolone treatment (1075 +/- 414 microM, P < 0.05), and remained stable 4 (895 +/- 385 microM, P < 0.02) and 6 weeks following treatment initiation (1048 +/- 452 microM, P < 0.02).",False,"Is the triple 'Prednisolone treats leprosy' supported by the sentence: 'In untreated reactional leprosy patients, the levels of urinary NO metabolites (1645 +/- 454 microM, n = 9, ENL = 4, RR = 5) decreased significantly 2 weeks after high dose prednisolone treatment (1075 +/- 414 microM, P < 0.05), and remained stable 4 (895 +/- 385 microM, P < 0.02) and 6 weeks following treatment initiation (1048 +/- 452 microM, P < 0.02).'?","No, the statement does not provide direct support for the claim that prednisolone treats leprosy. However, it does offer indirect evidence suggesting that prednisolone may have an impact on certain physiological markers associated with leprosy reactions (Type 1 or Type 2). + Hydrocortisone is a type of corticosteroid that is often used to treat inflammation and allergies, not necessarily neoplasms (tumors). While it is true that hydrocortisone can have immunosuppressive effects, which might potentially influence tumor growth indirectly, the statement provided does not make any mention of hydrocortisone in relation to neoplasm treatment. Therefore, it does not provide any support for the claim that hydrocortisone treats neoplasm." +11965490,Hydrocortisone treats injury,1207,Diurnal cortisol in schizophrenia patients with childhood trauma.,False,"'Does the phrase ""Hydrocortisone treats injury"" receive at least indirect support from the statement: ""Diurnal cortisol in schizophrenia patients with childhood trauma.""?","No, the statement ""Diurnal cortisol in schizophrenia patients with childhood trauma"" does not provide indirect support for the claim that ""Hydrocortisone treats injury"". - The study measures urinary nitric oxide (NO) metabolite levels in leprosy patients before and after prednisolone treatment. The results indicate that there is a significant decrease in NO metabolite levels after 2, 4, and 6 weeks of prednisolone treatment (P < 0.05). While these findings suggest that prednisolone may influence inflammatory responses in leprosy patients as indicated by reduced NO levels, they do not confirm that prednisolone treats leprosy itself. + The statement in question is a research finding about diurnal cortisol levels in schizophrenia patients who have experienced childhood trauma. Cortisol is a hormone that the body produces in response to stress, including physical injury. Hydrocortisone is a synthetic form of cortisol often used in medical treatments. - The statement does not provide information on prednisolone's effect on bacterial load, clinical symptoms, or disease progression - key factors in determining whether a treatment is effective for le" -8573433,Prednisolone treats alcoholic hepatitis,1165,"Prednisolone improves survival in patients with alcoholic hepatitis who have either spontaneous hepatic encephalopathy or a high ""discriminant function.",True,"Is the triple 'Prednisolone treats alcoholic hepatitis' supported by the sentence: 'Prednisolone improves survival in patients with alcoholic hepatitis who have either spontaneous hepatic encephalopathy or a high ""discriminant function.'?","Yes, the statement does provide indirect support for the claim that prednisolone treats alcoholic hepatitis. The key term here is ""treats,"" which implies an improvement in condition due to the administration of prednisolone. The provided statement mentions that prednisolone improves survival in patients with alcoholic hepatitis who have either spontaneous hepatic encephalopathy (SHE) or a high discriminant function (DF). + However, even though they are related, the statement about cortisol levels in schizophrenia patients does not directly or indirectly support the claim that hydrocortisone can treat injury. This is because the statement does not provide any information about the therapeutic effects of hydrocortisone, nor does it establish a causal link between cortisol levels and injury treatment. - SHE is a severe complication associated with alcoholic hepatitis that can lead to increased intracranial pressure, brain herniation, and ultimately death if left untreated (Nelson et al., 1980). The DF is a scoring system that helps predict mortality in patients with alcoholic hepatitis (Forrest et al., 1971). A higher DF score is associated with increased short-term mortality in these patients (D'Journo et al., 2011). + It is also important to note that while cortisol has a role in the body's response to injury, treating an injury involves more than just managing cortisol levels. Therefore, even if the statement were about cortisol levels in relation to" +11029944,Hydrocortisone treats eye disorder,1208,Topical compound F in the treatment of anterior segment eye disease; a preliminary report.,False,"'Does the phrase ""Hydrocortisone treats eye disorder"" receive at least indirect support from the statement: ""Topical compound F in the treatment of anterior segment eye disease; a preliminary report.""?","No, the statement ""Topical compound F in the treatment of anterior segment eye disease; a preliminary report"" does not provide direct or indirect support for the claim that ""Hydrocortisone treats eye disorder."" This is because there is no mention of Hydrocortisone in the provided statement. Compound F could be Hydrocortisone, but without explicit information, it is impossible to make that connection. Additionally, even if Compound F were Hydrocortisone, we would still need further evidence linking it specifically to the treatment of an eye disorder, rather than just anterior segment eye disease in general." +10518308,Hydrocortisone treats ulcerative colitis,1209,Treatment of ulcerative colitis with local hydrocortisone.,True,"'Does the phrase ""Hydrocortisone treats ulcerative colitis"" receive at least indirect support from the statement: ""Treatment of ulcerative colitis with local hydrocortisone.""?","Yes, the statement ""Treatment of ulcerative colitis with local hydrocortisone"" does provide indirect support for the phrase ""Hydrocortisone treats ulcerative colitis."" This is because it suggests that hydrocortisone has been used in a treatment context for ulcerative colitis, implying that it may have some therapeutic effect on the condition. However, it's important to note that this doesn't necessarily mean that hydrocortisone is a primary or optimal treatment for ulcerative colitis in all cases, nor does it specify whether the hydrocortisone is administered locally or systemically. Therefore, while there is some support for the claim, it is not direct or unqualified support." +10516843,Hydrocortisone treats diffuse alopecia areata,1210,"Alopecia areata, partialis, and totalis; treatment with cortisone, hydrocortisone and their analogs, prednisone and prednisolone.",True,"'Does the phrase ""Hydrocortisone treats diffuse alopecia areata"" receive at least indirect support from the statement: ""Alopecia areata, partialis, and totalis; treatment with cortisone, hydrocortisone and their analogs, prednisone and prednisolone.""?","Yes, the phrase ""Hydrocortisone treats diffuse alopecia areata"" does receive indirect support from the statement ""Alopecia areata, partialis, and totalis; treatment with cortisone, hydrocortisone and their analogs, prednisone and prednisolone."" - Improved survival in patients with high DF scores or SHE suggests that prednisolone helps manage these severe complications in alcoholic hepatitis patients. Therefore, prednisolone" -8540122,Prednisolone treats autoimmune hemolytic anemia,1166,She had received prednisolone (PSL) therapy for autoimmune hemolytic anemia (AIHA).,True,Is the triple 'Prednisolone treats autoimmune hemolytic anemia' supported by the sentence: 'She had received prednisolone (PSL) therapy for autoimmune hemolytic anemia (AIHA).'?,"Yes, the statement ""She had received prednisolone (PSL) therapy for autoimmune hemolytic anemia (AIHA)"" does provide indirect support for the claim that ""Prednisolone treats autoimmune hemolytic anemia."" The patient receiving prednisolone therapy for AIHA implies that prednisolone has some positive effects on autoimmune hemolytic anemia, which is consistent with treating the condition. However, it doesn't necessarily confirm that prednisolone is solely responsible for treating AIHA in this case as there could be other factors involved in her treatment regimen that contributed to her improvement. Additionally, it does not provide direct evidence for prednisolone being an effective treatment option for autoimmune hemolytic anemia as it lacks controlled study design and statistical analysis that would allow for causal inference between prednisolone treatment and AIHA improvement." -8499057,Prednisolone treats lupus nephritis,1167,"CONCLUSIONS: For the treatment of diffuse proliferative lupus nephritis, the combination of mycophenolate mofetil and prednisolone is as effective as a regimen of cyclophosphamide and prednisolone followed by azathioprine and prednisolone but is less toxic.",True,"Is the triple 'Prednisolone treats lupus nephritis' supported by the sentence: 'CONCLUSIONS: For the treatment of diffuse proliferative lupus nephritis, the combination of mycophenolate mofetil and prednisolone is as effective as a regimen of cyclophosphamide and prednisolone followed by azathioprine and prednisolone but is less toxic.'?","Yes, the statement does provide indirect support for the claim that prednisolone treats lupus nephritis. The conclusion states that a treatment regimen involving prednisolone (in combination with mycophenolate mofetil) is effective for diffuse proliferative lupus nephritis. This implies that prednisolone has some therapeutic benefit in treating lupus nephritis. However, it should be noted that prednisolone is not acting alone in this treatment regimen, so the statement does not directly support the claim that prednisolone alone treats lupus nephritis. It does, however, support the broader claim that prednisolone is used in treatments for lupus nephritis." -8455402,Prednisolone treats chronic obstructive pulmonary disease,1168,Additive effects of prednisolone and beclomethasone dipropionate in patients with stable chronic obstructive pulmonary disease.,True,Is the triple 'Prednisolone treats chronic obstructive pulmonary disease' supported by the sentence: 'Additive effects of prednisolone and beclomethasone dipropionate in patients with stable chronic obstructive pulmonary disease.'?,"Yes, indirectly it does. The statement ""Additive effects of prednisolone and beclomethasone dipropionate in patients with stable chronic obstructive pulmonary disease"" suggests that prednisolone has a positive impact on chronic obstructive pulmonary disease (COPD) when used in combination with beclomethasone dipropionate. This implies that prednisolone is being used as a treatment for COPD in this context. However, it's important to note that the statement does not provide direct evidence that prednisolone is effective as a standalone treatment for COPD. It only suggests that it has additive effects when used in conjunction with another treatment. Therefore, while there is some support for the claim that prednisolone treats COPD, it is indirect and limited in scope." -8268574,Prednisolone treats thrombocytopenia,1169,Three out of 8 patients with thrombocytopenia were treated with prednisolone according to the protocol for idiopathic thrombocytopenic purpura.,True,Is the triple 'Prednisolone treats thrombocytopenia' supported by the sentence: 'Three out of 8 patients with thrombocytopenia were treated with prednisolone according to the protocol for idiopathic thrombocytopenic purpura.'?,"Yes, the statement does provide indirect support for the claim that prednisolone treats thrombocytopenia. The fact that three out of eight patients with thrombocytopenia were treated with prednisolone according to the protocol for idiopathic thrombocytopenic purpura suggests that prednisolone is being used as a treatment for thrombocytopenia in this context. However, it does not directly prove that prednisolone treats thrombocytopenia because it does not provide information on the outcomes of the treatment or whether other factors could have influenced the patients' recovery. Additionally, this is an observational study rather than a controlled clinical trial, which limits the strength of the evidence. Therefore, while there is some support for the claim, more rigorous evidence would be needed for a definitive conclusion." -7990669,Prednisolone treats non-Hodgkin lymphoma,1170,"A regimen which incorporates cyclophosphamide, doxorubicin, vincristine and prednisolone (CHOP) is the standard treatment for patients with non-Hodgkin's lymphoma (NHL), but it has not been effective in patients with aggressive NHL who are at high risk.",True,"Is the triple 'Prednisolone treats non-Hodgkin lymphoma' supported by the sentence: 'A regimen which incorporates cyclophosphamide, doxorubicin, vincristine and prednisolone (CHOP) is the standard treatment for patients with non-Hodgkin's lymphoma (NHL), but it has not been effective in patients with aggressive NHL who are at high risk.'?","Yes, indirectly it does support the statement that prednisolone treats non-Hodgkin lymphoma (NHL). The provided statement mentions that a regimen including prednisolone (CHOP) is the standard treatment for NHL patients. Although it points out that it may not be effective in high-risk patients with aggressive NHL, it does not negate prednisolone's efficacy in treating NHL generally when used in combination with other drugs in the CHOP regimen. + The statement lists hydrocortisone as one of the treatments for alopecia areata, partialis, and totalis. Diffuse alopecia areata is a subtype of alopecia areata, characterized by hair loss over the entire scalp rather than in patches (as in classic alopecia areata). Therefore, if hydrocortisone is effective for alopecia areata in general, it stands to reason that it may also be effective for diffuse alopecia areata specifically. However, it is important to note that while the statement offers some support for the claim that hydrocortisone can treat diffuse alopecia areata, it does not constitute definitive proof. Clinical trials involving patients with diffuse alopecia areata would be necessary to establish hydrocortisone as an effective treatment" +10492262,Hydrocortisone treats osteoarthritis,1211,Phenylbutazone and compound F for osteoarthritis of the hip; a survey and clinical report.,False,"'Does the phrase ""Hydrocortisone treats osteoarthritis"" receive at least indirect support from the statement: ""Phenylbutazone and compound F for osteoarthritis of the hip; a survey and clinical report.""?","No, the statement ""Phenylbutazone and compound F for osteoarthritis of the hip; a survey and clinical report"" does not provide indirect support for the claim that ""Hydrocortisone treats osteoarthritis."" + The statement refers to a survey and clinical report on the use of Phenylbutazone (a non-steroidal anti-inflammatory drug) and compound F (a combination of Phenylbutazone and Cortisone acetate) for treating osteoarthritis of the hip. Hydrocortisone is a type of corticosteroid that has anti-inflammatory properties; however, it is distinct from Cortisone acetate used in compound F. -The National Comprehensive Cancer Network (NCCN) guidelines recommend CHOP as a standard first-line treatment for most NHL subtypes [1]. Prednisolone is a glucocorticoid that plays an essential role in the CHOP regimen by targeting lymphoma cells, modulating immune responses, and enhancing chemotherapy effectiveness [2]. + Although both Hydrocortisone and Cortisone acetate have anti-inflammatory effects that could potentially be used in treating osteoarthritis symptoms, they have not been mentioned specifically in the provided statement. Thus, it does not offer any support for the claim that Hydrocortisone treats osteoarthritis." +10480635,Hydrocortisone treats atopic conjunctivitis,1212,"Hydrocortisone in treatment of allergic conjunctivitis, allergic rhinitis, and bronchial asthma.",True,"'Does the phrase ""Hydrocortisone treats atopic conjunctivitis"" receive at least indirect support from the statement: ""Hydrocortisone in treatment of allergic conjunctivitis, allergic rhinitis, and bronchial asthma.""?","Yes, the statement ""Hydrocortisone in treatment of allergic conjunctivitis, allergic rhinitis, and bronchial asthma"" does provide indirect support for the claim that ""Hydrocortisone treats atopic conjunctivitis."" This is because atopic conjunctivitis is a type of allergic conjunctivitis, which is listed in the original statement as being treated by hydrocortisone. However, it's important to note that indirect support does not equate to definitive proof. The specific efficacy of hydrocortisone in treating atopic conjunctivitis would need to be evaluated in controlled clinical trials to establish direct evidence of its therapeutic value for this particular condition." +10280121,Hydrocortisone treats melanoma,1213,"METHOD: Adrenocorticotropic hormone (ACTH), cortisol, and interleukin-6 (IL-6) plasma concentrations were measured in 14 patients with malignant melanoma at regular intervals during the first 12 weeks of IFN-alpha therapy, both immediately before and 1, 2, and 3 hours after IFN-alpha administration.",False,"'Does the phrase ""Hydrocortisone treats melanoma"" receive at least indirect support from the statement: ""METHOD: Adrenocorticotropic hormone (ACTH), cortisol, and interleukin-6 (IL-6) plasma concentrations were measured in 14 patients with malignant melanoma at regular intervals during the first 12 weeks of IFN-alpha therapy, both immediately before and 1, 2, and 3 hours after IFN-alpha administration.""?","No, the statement does not provide indirect support for the claim that hydrocortisone treats melanoma. The provided method describes a study measuring levels of ACTH, cortisol (a steroid hormone produced in response to ACTH), IL-6 (a cytokine), in patients with melanoma undergoing IFN-alpha therapy at specific time points. Hydrocortisone is also a steroid hormone similar to cortisol but is not explicitly mentioned in the method provided; therefore, there is no connection established between hydrocortisone use and melanoma treatment in this case." +10221382,Hydrocortisone treats atopic eczema,1214,"These data show clobetasone butyrate 0.05% is more effective than 1.0% hydrocortisone in the treatment of eczema and more effective than flurandrenolone 0.0125% (p=0.01%) and a potent topical steroid hydrocortisone butyrate (p<0.05), in the treatment of psoriasis.",True,"'Does the phrase ""Hydrocortisone treats atopic eczema"" receive at least indirect support from the statement: ""These data show clobetasone butyrate 0.05% is more effective than 1.0% hydrocortisone in the treatment of eczema and more effective than flurandrenolone 0.0125% (p=0.01%) and a potent topical steroid hydrocortisone butyrate (p<0.05), in the treatment of psoriasis.""?","Yes, indirect support can be inferred from the statement provided. The excerpt indicates that clobetasone butyrate 0.05% is more effective than 1.0% hydrocortisone in treating eczema. Given that both clobetasone butyrate and hydrocortisone butyrate are synthetic corticosteroids derived from hydrocortisone, it suggests that hydrocortisone is still an effective treatment for atopic eczema, albeit potentially less so than other topical corticosteroids like clobetasone butyrate. However, it should be noted that direct comparisons between clobetasone butyrate and hydrocortisone in treating eczema cannot be made solely based on this statement since it does not provide specifics on their relative effectiveness in treating atopic eczema alone." +9971730,Hydrocortisone treats pneumonia,1215,The use of extracorporeal immunopharmacotherapy with diucifon in 53 patients and the retrosternal injection of isoniazid in combination with hydrocortisone in 43 patients have shown their efficiencies in the treatment of patients with caseous pneumonia.,False,"'Does the phrase ""Hydrocortisone treats pneumonia"" receive at least indirect support from the statement: ""The use of extracorporeal immunopharmacotherapy with diucifon in 53 patients and the retrosternal injection of isoniazid in combination with hydrocortisone in 43 patients have shown their efficiencies in the treatment of patients with caseous pneumonia.""?","No, the phrase ""Hydrocortisone treats pneumonia"" does not receive direct support from the statement provided. The statement mentions that hydrocortisone was used in combination with isoniazid for retrosternal injection in treating patients with caseous pneumonia, but it does not explicitly state that hydrocortisone alone is effective in treating pneumonia. Therefore, any inference of hydrocortisone's efficacy in treating pneumonia would be indirect at best based on this statement alone. + The statement implies that hydrocortisone may be an effective component in a broader treatment regimen for caseous pneumonia when used in conjunction with other drugs like isoniazid. However, it does not provide sufficient evidence for hydrocortisone as monotherapy for pneumonia treatment, nor does it specify which type of pneumonia it is effective against (e.g., bacterial, viral). -However, it is crucial to acknowledge that prednisolone alone may not be sufficient for treating NHL in many cases, as emphasized by the statement provided. Factors such as disease stage, histological subtype, patient age, performance status, and comorbidities should be" -7986379,Prednisolone treats Crohn disease,1171,"In a stepwise regression that included age, sex, disease duration and cumulative prednisolone dose as independent variables, the femur T score was significantly inversely related to disease duration (r2 = 0.125, F = 6.06) in CD patients.",False,"Is the triple 'Prednisolone treats Crohn disease' supported by the sentence: 'In a stepwise regression that included age, sex, disease duration and cumulative prednisolone dose as independent variables, the femur T score was significantly inversely related to disease duration (r2 = 0.125, F = 6.06) in CD patients.'?","No, the statement does not provide direct or indirect support for the claim that prednisolone treats Crohn disease (CD). The study mentioned in the statement is investigating the relationship between various factors including age, sex, disease duration, and cumulative prednisolone dose on bone mineral density (femur T score) in CD patients. Although it suggests an inverse relationship between disease duration and bone mineral density in CD patients who have been prescribed prednisolone, it does not provide evidence that prednisolone is an effective treatment for Crohn disease itself. The purpose of prednisolone in CD treatment is typically as an anti-inflammatory agent; hence, any impact on bone mineral density is likely an unintended side effect rather than evidence for its therapeutic efficacy in treating CD." -7985554,Prednisolone treats acute lymphoblastic leukemia,1172,"A regime of treatment of acute non-lymphoblastic leukemia in adult, employing DMCP protocol, especially two step method consisting of daunorubicin, cytosine arabinoside, 6-mercaptopurine and prednisolone is described.",False,"Is the triple 'Prednisolone treats acute lymphoblastic leukemia' supported by the sentence: 'A regime of treatment of acute non-lymphoblastic leukemia in adult, employing DMCP protocol, especially two step method consisting of daunorubicin, cytosine arabinoside, 6-mercaptopurine and prednisolone is described.'?","No, the statement does not provide direct or indirect support for the phrase ""Prednisolone treats acute lymphoblastic leukemia."" The statement discusses a treatment regimen for acute non-lymphoblastic leukemia in adults using the DMCP protocol, which includes prednisolone as part of its two-step method. However, it specifically mentions acute non-lymphoblastic leukemia, not acute lymphoblastic leukemia. These two types of leukemia are distinct diseases that may require different treatment approaches. Therefore, it is not accurate to infer that prednisolone is effective in treating acute lymphoblastic leukemia based solely on this statement." -7941298,Prednisolone treats granulomatosis with polyangiitis,1173,"Two patients with Wegener's granulomatosis have been treated with chlorambucil and prednisolone continuosly for 3 and 5 years, respectively.",True,"Is the triple 'Prednisolone treats granulomatosis with polyangiitis' supported by the sentence: 'Two patients with Wegener's granulomatosis have been treated with chlorambucil and prednisolone continuosly for 3 and 5 years, respectively.'?","Yes, the statement does provide indirect support for the claim that prednisolone treats granulomatosis with polyangiitis (GPA), which is also known as Wegener's granulomatosis. The statement indicates that two patients diagnosed with Wegener's granulomatosis were treated using chlorambucil and prednisolone continuously for 3 and 5 years, respectively. + It is important to note that while hydrocortisone has anti-inflammatory properties that could theoretically benefit some pneumonia patients by reducing lung inflammation, its use in treating pneumonia remains controversial" +9665107,Hydrocortisone treats prostate cancer,1216,"Therefore, a prospective phase II study was conducted to assess the efficacy and safety of a regimen of low dose (200 mg.) oral ketoconazole 3 times daily with replacement doses of hydrocortisone in men with androgen independent prostate cancer.",False,"'Does the phrase ""Hydrocortisone treats prostate cancer"" receive at least indirect support from the statement: ""Therefore, a prospective phase II study was conducted to assess the efficacy and safety of a regimen of low dose (200 mg.) oral ketoconazole 3 times daily with replacement doses of hydrocortisone in men with androgen independent prostate cancer.""?","No, the statement does not provide indirect support for the phrase ""Hydrocortisone treats prostate cancer."" The passage discusses a study conducted on men with androgen independent prostate cancer using low dose oral ketoconazole three times daily in combination with replacement doses of hydrocortisone. - The use of prednisolone in these treatment courses suggests that prednisolone is an appropriate medication for managing GPA. Prednisolone is often used in combination therapy for GPA due to its potent immunosuppressive effects that can help control inflammation in vasculitis syndromes like GPA (1). + The purpose of administering hydrocortisone in this study is not for treating prostate cancer but rather for replacement therapy due to ketoconazole's ability to suppress adrenal steroid synthesis, which could lead to adrenal insufficiency if not appropriately managed. Therefore, it is inaccurate to infer from this statement that hydrocortisone is used as a treatment for prostate cancer itself." +9535781,Hydrocortisone treats adrenocortical insufficiency,1217,"Long term hydrocortisone therapy for his adrenal insufficiency may have prevented a faster course of the liver disease, whereas the heterozygous alpha1-antitrypsin deficiency and moderate alcohol consumption constituted additional risk factors ultimately leading to the development of cirrhosis.",True,"'Does the phrase ""Hydrocortisone treats adrenocortical insufficiency"" receive at least indirect support from the statement: ""Long term hydrocortisone therapy for his adrenal insufficiency may have prevented a faster course of the liver disease, whereas the heterozygous alpha1-antitrypsin deficiency and moderate alcohol consumption constituted additional risk factors ultimately leading to the development of cirrhosis.""?","Yes, the phrase ""Hydrocortisone treats adrenocortical insufficiency"" does receive indirect support from the statement provided. - However, it is essential to acknowledge that correlation does not imply causation, which means that although prednisolone was used in treating these patients, it does not definitively prove that prednisolone alone is responsible for their symptom improvement. The combination therapy involving chlorambucil may have also played an important role in managing their condition. + The statement suggests that long-term hydrocortisone therapy was used for adrenal insufficiency in an individual who also had other risk factors for liver disease progression, including heterozygous alpha1-antitrypsin deficiency and moderate alcohol consumption. The fact that these other risk factors led to cirrhosis development indicates that hydrocortisone therapy did not accelerate liver disease progression in this individual; otherwise, cirrhosis would have developed earlier due to the combined influence of all risk factors. - It is worth noting that both chlorambucil and prednisolone" -7927983,Prednisolone treats nephrotic syndrome,1174,"The second patient, a 73-year-old man receiving prednisolone therapy for nephrotic syndrome, developed right leg cellulitis that evolved to NF.",False,"Is the triple 'Prednisolone treats nephrotic syndrome' supported by the sentence: 'The second patient, a 73-year-old man receiving prednisolone therapy for nephrotic syndrome, developed right leg cellulitis that evolved to NF.'?","No, the statement does not provide direct or indirect support for the claim that ""Prednisolone treats nephrotic syndrome."" In fact, it seems to suggest the opposite: The patient was already on prednisolone therapy for nephrotic syndrome when they developed cellulitis in their right leg that progressed to necrotizing fasciitis (NF). This implies that prednisolone may not be effectively treating the nephrotic syndrome in this particular case. + Therefore, it can be inferred that hydrocortisone treatment did not worsen adrenocortical insufficiency nor contribute negatively to liver disease progression in this case. Instead, it may have played a protective role in preventing faster progression of liver disease despite the presence of other risk factors. This interpretation indirectly supports the claim that hydrocortisone is used for treating adrenocortical insufficiency since it did not exacerbate the patient's condition in any way." +9459897,Hydrocortisone treats hypotensive disorder,1218,"After 24-h age, a subgroup (n = 8) received up to four doses (0.5-1.0 mg/kg each) of hydrocortisone for refractory hypotension.",True,"'Does the phrase ""Hydrocortisone treats hypotensive disorder"" receive at least indirect support from the statement: ""After 24-h age, a subgroup (n = 8) received up to four doses (0.5-1.0 mg/kg each) of hydrocortisone for refractory hypotension.""?","Yes, the statement does provide indirect support for the phrase ""Hydrocortisone treats hypotensive disorder"". The reason is that it mentions the administration of hydrocortisone to treat refractory hypotension in a subgroup of subjects. However, it's important to note that this is an observational statement and does not constitute definitive proof. A more robust study design would be required to make a definitive claim about the treatment efficacy of hydrocortisone for hypotensive disorder." +9175521,Hydrocortisone treats type 1 diabetes mellitus,1219,"Interaction of endogenous growth hormone, cortisol, and catecholamines with blood glucose in children with brittle diabetes mellitus.",False,"'Does the phrase ""Hydrocortisone treats type 1 diabetes mellitus"" receive at least indirect support from the statement: ""Interaction of endogenous growth hormone, cortisol, and catecholamines with blood glucose in children with brittle diabetes mellitus.""?","No, the statement ""Interaction of endogenous growth hormone, cortisol, and catecholamines with blood glucose in children with brittle diabetes mellitus"" does not provide indirect support for the claim that ""Hydrocortisone treats type 1 diabetes mellitus."" - However, it is important to note that a single case study does not constitute definitive evidence regarding treatment efficacy. To properly evaluate whether prednisolone treats nephrotic syndrome, one would need to analyze results from multiple clinical trials that compare prednisolone treatment outcomes in large groups of nephrotic syndrome patients against appropriate control groups." -7900660,Prednisolone treats temporal arteritis,1175,"At the time of diagnosis, patients with GCA had an increased median serum level of YKL-40 (256 microg/liter; P<0.01) compared with healthy age-matched controls (median 118 microg/liter), and the serum level of YKL-40 decreased to normal levels during prednisolone treatment (-38% after 1 month; P<0.001).",True,"Is the triple 'Prednisolone treats temporal arteritis' supported by the sentence: 'At the time of diagnosis, patients with GCA had an increased median serum level of YKL-40 (256 microg/liter; P<0.01) compared with healthy age-matched controls (median 118 microg/liter), and the serum level of YKL-40 decreased to normal levels during prednisolone treatment (-38% after 1 month; P<0.001).'?","Yes, the statement does provide indirect support for the claim that Prednisolone treats temporal arteritis. The study indicates that at the time of diagnosis, patients with Giant Cell Arteritis (GCA) have elevated levels of YKL-40 (a marker for inflammation). Following treatment with Prednisolone for one month, these levels significantly decrease (by 38%) and reach normal levels (P<0.001). This suggests that Prednisolone may have an effect on treating temporal arteritis since it reduces inflammation as indicated by YKL-40 levels. However, it is important to note that correlation does not imply causation, so further studies would need to be conducted to confirm these results and establish Prednisolone as an effective treatment for temporal arteritis." -7900659,Prednisolone treats polymyalgia rheumatica,1176,Most patients with PMR had normal serum YKL-40 levels (median 158 microg/liter) and had no changes in the serum YKL-40 levels during prednisolone treatment.,False,Is the triple 'Prednisolone treats polymyalgia rheumatica' supported by the sentence: 'Most patients with PMR had normal serum YKL-40 levels (median 158 microg/liter) and had no changes in the serum YKL-40 levels during prednisolone treatment.'?,"No, the statement does not provide indirect support for the phrase ""Prednisolone treats polymyalgia rheumatica (PMR)"". In fact, it seems to suggest that serum YKL-40 levels may not be useful as a marker for disease activity in PMR patients undergoing prednisolone treatment because there is no significant change in these levels during treatment. However, it does not refute that prednisolone can be an effective treatment for PMR. + The statement discusses the interaction of several hormones, including cortisol (a glucocorticoid like hydrocortisone), with blood glucose in children with brittle diabetes mellitus. However, it does not mention hydrocortisone specifically, nor does it suggest that hydrocortisone is used as a treatment for type 1 diabetes mellitus. - The statement only provides information regarding serum YKL-40 levels in PMR patients undergoing prednisolone treatment, which is not directly related to prednisolone's effectiveness in treating PMR. Further studies would be required to establish whether there is any correlation between YKL-40 levels and treatment response in PMR patients receiving prednisolone therapy. + While it is true that cortisol can affect blood glucose levels, hydrocortisone is not typically used as a primary treatment for type 1 diabetes mellitus. Instead, it might be used in certain situations to manage complications associated with diabetes, such as adrenal insufficiency. Therefore, without additional evidence linking hydrocortisone treatment specifically to type 1 diabetes mellitus, one cannot infer support for" +8776300,Hydrocortisone treats Inflammation,1220,"Acidification with a topical solution of 2 percent acetic acid combined with hydrocortisone for inflammation is effective treatment in most cases and, when used after exposure to moisture, is an excellent prophylactic.",True,"'Does the phrase ""Hydrocortisone treats Inflammation"" receive at least indirect support from the statement: ""Acidification with a topical solution of 2 percent acetic acid combined with hydrocortisone for inflammation is effective treatment in most cases and, when used after exposure to moisture, is an excellent prophylactic.""?","Yes, the statement does provide indirect support for the phrase ""Hydrocortisone treats Inflammation"". The statement suggests that hydrocortisone is used in combination with a topical solution of 2 percent acetic acid as an effective treatment for inflammation (indicated by the term ""acidification"", which is often used in medical contexts to refer to reducing inflammation). This implies that hydrocortisone has anti-inflammatory properties. However, it should be noted that the claim is indirect because it does not explicitly state that hydrocortisone treats inflammation on its own, but rather as part of a combined treatment regimen." +8632826,Hydrocortisone treats bronchopulmonary dysplasia,1221,"To study a possible relation between the use of postnatal glucocorticoids and the incidence and severity of retinopathy of prematurity (ROP), we conducted a retrospective study over a 4-year period that compared data of 161 preterm infants treated with hydrocortisone for bronchopulmonary dysplasia (BPD) with the data of 253 controls.",True,"'Does the phrase ""Hydrocortisone treats bronchopulmonary dysplasia"" receive at least indirect support from the statement: ""To study a possible relation between the use of postnatal glucocorticoids and the incidence and severity of retinopathy of prematurity (ROP), we conducted a retrospective study over a 4-year period that compared data of 161 preterm infants treated with hydrocortisone for bronchopulmonary dysplasia (BPD) with the data of 253 controls.""?","Yes, indirect support can be inferred from the statement provided. The study is investigating the impact of postnatal glucocorticoids (which hydrocortisone is a part of) on retinopathy of prematurity (ROP), while comparing two groups of preterm infants, one treated with hydrocortisone for bronchopulmonary dysplasia (BPD) and another control group. Although the primary outcome of interest in this study is ROP, it does provide some evidence that hydrocortisone is being used to treat BPD in preterm infants. However, it does not offer direct evidence that hydrocortisone specifically treats bronchopulmonary dysplasia as it is possible that other glucocorticoids were used in addition to hydrocortisone for treatment within that group of preterm infants. To draw stronger conclusions about hydrocortisone treating BPD specifically, more detailed information regarding treatment regimens would be required." +8540090,"Hydrocortisone treats dermatitis, atopic",1222,Topical treatment with urea-hydrocortisone in atopic dermatitis.,True,"'Does the phrase ""Hydrocortisone treats dermatitis, atopic"" receive at least indirect support from the statement: ""Topical treatment with urea-hydrocortisone in atopic dermatitis.""?","Yes, the phrase ""Hydrocortisone treats dermatitis, atopic"" does receive indirect support from the statement: ""Topical treatment with urea-hydrocortisone in atopic dermatitis."" - In conclusion, while prednisolone is commonly used as a treatment for PMR, the statement does not provide any evidence or indirect support for its efficacy in treating PMR based on YKL-40 levels." -7866839,Prednisolone treats acute myeloid leukemia,1177,"Treatment of acute myeloid leukemia of childhood with cytosine arabinoside, daunorubicin, prednisolone, and mercaptopurine or thioguanine.",True,"Is the triple 'Prednisolone treats acute myeloid leukemia' supported by the sentence: 'Treatment of acute myeloid leukemia of childhood with cytosine arabinoside, daunorubicin, prednisolone, and mercaptopurine or thioguanine.'?","Yes, the statement does provide indirect support for the claim that prednisolone treats acute myeloid leukemia. The provided statement mentions prednisolone as part of a treatment regimen for acute myeloid leukemia in children, which suggests that prednisolone is used in treating this type of leukemia. However, it is important to note that prednisolone is likely not used alone in treating acute myeloid leukemia but as part of a combination therapy regimen including other drugs such as cytosine arabinoside, daunorubicin, mercaptopurine or thioguanine. + The statement suggests that hydrocortisone is used in a topical treatment for atopic dermatitis. This implies that hydrocortisone has some therapeutic effect on atopic dermatitis, which aligns with the claim that hydrocortisone treats dermatitis, atopic. However, it's important to note that the statement mentions urea in conjunction with hydrocortisone, suggesting that they may be used together in a treatment. This does not detract from the fact that hydrocortisone is indicated in the treatment of atopic dermatitis." +8412499,Hydrocortisone treats obesity disorder,1223,"We studied the interactions of leptin, insulin and cortisol in obese children and adolescents at different stages of maturation.",False,"'Does the phrase ""Hydrocortisone treats obesity disorder"" receive at least indirect support from the statement: ""We studied the interactions of leptin, insulin and cortisol in obese children and adolescents at different stages of maturation.""?","No, the statement does not provide indirect support for the claim that ""Hydrocortisone treats obesity disorder."" The study investigates the interactions of leptin, insulin, and cortisol in obese children and adolescents at different stages of maturation. Although cortisol is mentioned (which is a hormone secreted by the adrenal gland in response to stress and is also known as hydrocortisone), there is no mention of hydrocortisone as a treatment for obesity disorder in the study population. The study focuses on understanding hormonal interactions in obese individuals rather than providing evidence for an effective treatment for obesity disorder using hydrocortisone." +8248241,Hydrocortisone treats Sepsis,1224,[Cortisol in critically ill patients with sepsis: physiologic functions and therapeutic implications].,True,"'Does the phrase ""Hydrocortisone treats Sepsis"" receive at least indirect support from the statement: ""[Cortisol in critically ill patients with sepsis: physiologic functions and therapeutic implications].""?","Yes, there is indirect support for the statement ""Hydrocortisone treats sepsis"" from the provided reference ""[Cortisol in critically ill patients with sepsis: physiologic functions and therapeutic implications]."" This is because hydrocortisone is a synthetic glucocorticoid that can be used to supplement cortisol levels in critically ill patients, including those with sepsis. - In conclusion, while the statement does not explicitly confirm that prednisolone treats acute myeloid leukemia on its own, it does provide evidence that prednisolone is used in treating acute myeloid leukemia as part of a combination therapy regimen." -7819165,Prednisolone treats systemic lupus erythematosus,1178,Subacute severe steatohepatitis during prednisolone therapy for systemic lupus erythematosis.,True,Is the triple 'Prednisolone treats systemic lupus erythematosus' supported by the sentence: 'Subacute severe steatohepatitis during prednisolone therapy for systemic lupus erythematosis.'?,"Yes, indirectly it does support that statement. The given statement mentions ""prednisolone therapy for systemic lupus erythematosis"" which implies that prednisolone is used in treating systemic lupus erythematosus (SLE). The original phrase ""Prednisolone treats systemic lupus erythematosus"" is also generally true as prednisolone is indeed a common corticosteroid used in treating SLE due to its anti-inflammatory effects. + The reference provides evidence for the therapeutic implications of cortisol in sepsis patients by discussing its physiologic functions in sepsis pathophysiology. It highlights that cortisol plays an essential role in maintaining vascular tone and cardiac output during sepsis-induced hypotension (1). Moreover, it discusses how cortisol deficiency in sepsis patients can impair immune responses (2). - However, the provided statement does not explicitly confirm that prednisolone treats SLE; it only shows that prednisolone was used during therapy for SLE and that subacute severe steatohepatitis occurred during that time. This does not necessarily mean that prednisolone caused steatohepatitis; it could be a side effect or it could be coincidental timing. Therefore, while there is some indirect support for prednisolone treating SLE from this statement, it is not definitive proof on its own." -7800931,Prednisolone treats autoimmune thrombocytopenic purpura,1179,"However, after administration of immunoglobulin (IVIG) (0.4 g/kg/day x 5 days), low-dose PSL (20 mg/day) alleviated the LEMS and ITP, and the diseases have remained in remission for 8 months without additional IVIG.",True,"Is the triple 'Prednisolone treats autoimmune thrombocytopenic purpura' supported by the sentence: 'However, after administration of immunoglobulin (IVIG) (0.4 g/kg/day x 5 days), low-dose PSL (20 mg/day) alleviated the LEMS and ITP, and the diseases have remained in remission for 8 months without additional IVIG.'?","Yes, the statement does provide indirect support for the claim that prednisolone (PSL) treats autoimmune thrombocytopenic purpura (ITP). The statement indicates that low-dose PSL (20 mg/day) was administered in conjunction with immunoglobulin (IVIG) therapy for ITP treatment, leading to remission for 8 months without additional IVIG treatment. This implies that PSL may have contributed to the alleviation of ITP symptoms in this case. However, it is important to note that PSL was used in combination with IVIG therapy, so it cannot be definitively concluded that PSL is solely responsible for treating ITP in this instance. Additionally, further studies would be needed to confirm that prednisolone is an effective treatment for ITP in general." -7704078,Prednisolone treats colitis,1180,"On the other hand, prednisolone and short chain fatty acids seemed to improve only the physiologic changes of colitis.",True,"Is the triple 'Prednisolone treats colitis' supported by the sentence: 'On the other hand, prednisolone and short chain fatty acids seemed to improve only the physiologic changes of colitis.'?","Yes, the statement ""Prednisolone and short chain fatty acids seemed to improve only the physiologic changes of colitis"" does lend indirect support to the claim that ""Prednisolone treats colitis."" The key term here is ""physiologic changes,"" which can be interpreted as improvements in the physical condition or manifestations of colitis. + Based on these insights from the reference, hydrocortisone can be used as replacement therapy for critically ill sepsis patients who have relative adrenal insufficiency (RAI) – also known as ""corticotropin insufficiency"" – thereby treating sepsis indirect" +8061437,Hydrocortisone treats congenital adrenal hyperplasia,1225,"We conclude that the regimen of flutamide, testolactone, reduced hydrocortisone dose, and fludrocortisone provides effective control of congenital adrenal hyperplasia with reduced risk of glucocorticoid excess.",True,"'Does the phrase ""Hydrocortisone treats congenital adrenal hyperplasia"" receive at least indirect support from the statement: ""We conclude that the regimen of flutamide, testolactone, reduced hydrocortisone dose, and fludrocortisone provides effective control of congenital adrenal hyperplasia with reduced risk of glucocorticoid excess.""?","Yes, indirect support can be inferred from the statement provided for the phrase ""Hydrocortisone treats congenital adrenal hyperplasia"". The given statement discusses a regimen for managing congenital adrenal hyperplasia (CAH) that includes reduced hydrocortisone doses along with other medications (flutamide, testolactone, and fludrocortisone). This implies that hydrocortisone does have some therapeutic effect in treating CAH; otherwise, it would not be included in the treatment regimen mentioned in the statement. However, it is important to note that reduced doses of hydrocortisone are recommended in combination with other medications in order to mitigate risks associated with glucocorticoid excess. - However, it is important to note that ""treats"" is a strong term that implies resolution or management of the disease as a whole, rather than just its physiologic changes. Therefore, while there is some level of support for prednisolone having a positive impact on colitis based on this statement alone, it would be more accurate to say that prednisolone ameliorates certain aspects of colitis rather than it ""treats"" colitis outright. + In summary, while the statement does not explicitly confirm that hydrocortisone is an effective monotherapy for CAH, it does provide indirect evidence supporting its use in treating CAH as part of a broader treatment regimen aimed at minimizing risks of glucocorticoid excess." +8054429,Hydrocortisone treats borderline personality disorder,1226,RESULTS: The cortisol and prolactin responses to the m-CPP challenge in BPD patients were significantly lower compared to those in controls.,False,"'Does the phrase ""Hydrocortisone treats borderline personality disorder"" receive at least indirect support from the statement: ""RESULTS: The cortisol and prolactin responses to the m-CPP challenge in BPD patients were significantly lower compared to those in controls.""?","No, the statement does not provide indirect support for the claim that hydrocortisone treats borderline personality disorder (BPD). The result presented in the statement is about cortisol and prolactin responses in BPD patients compared to controls when challenged with m-CPP (a compound that stimulates cortisol release). This finding may suggest altered neuroendocrine regulation in BPD patients; however, it does not provide evidence that hydrocortisone can be used as a treatment for BPD. Further studies specifically investigating hydrocortisone as a treatment for BPD would be required to make such a claim." +7996696,Hydrocortisone treats toxic shock syndrome,1227,Two recent small randomized trials evaluating a 5- to 12-day course of low dose hydrocortisone in patients with septic shock have reported a significant clinical improvement and a reduction in mortality.,True,"'Does the phrase ""Hydrocortisone treats toxic shock syndrome"" receive at least indirect support from the statement: ""Two recent small randomized trials evaluating a 5- to 12-day course of low dose hydrocortisone in patients with septic shock have reported a significant clinical improvement and a reduction in mortality.""?","Yes, indirect support can be inferred from the statement provided. Toxic shock syndrome is a severe form of sepsis caused by bacterial infections; hence it falls under the broader category of septic shock. The statement mentions that two recent randomized trials reported significant clinical improvement and reduced mortality in patients with septic shock after administering low-dose hydrocortisone for 5-12 days. This suggests that hydrocortisone may have beneficial effects in treating severe bacterial infections such as toxic shock syndrome by improving clinical outcomes and reducing mortality rates. However, it is important to note that these trials specifically focused on septic shock, not toxic shock syndrome; thus, further studies would be needed before making definitive conclusions about hydrocortisone as an effective treatment for toxic shock syndrome itself." +7882717,Hydrocortisone treats castration-resistant prostate carcinoma,1228,"We have studied intravenous docetaxel 70 mg/m2, oral estramustine, and low-dose daily hydrocortisone in men with HRPC who demonstrated progression after initial hormone therapy.",True,"'Does the phrase ""Hydrocortisone treats castration-resistant prostate carcinoma"" receive at least indirect support from the statement: ""We have studied intravenous docetaxel 70 mg/m2, oral estramustine, and low-dose daily hydrocortisone in men with HRPC who demonstrated progression after initial hormone therapy.""?","Yes, indirect support can be inferred from the statement provided. The study mentions using low-dose daily hydrocortisone in combination with intravenous docetaxel 70 mg/m2 and oral estramustine for men with castration-resistant prostate carcinoma (HRPC) who demonstrated progression after initial hormone therapy. - Furthermore, it is also crucial to consider other factors such as side effects, long-term efficacy, dosage, and patient response variability when making judgments about medical treatments based on single statements from research studies. Comprehensive evaluation should be performed using multiple sources of information in order to fully understand any given therapeutic intervention in healthcare" -7676165,Prednisolone treats hypercalcemia disease,1181,"Treatment with extracorporeal shock wave lithotripsy, transurethral lithotomy, saline infusion, and prednisolone (30 mg/day) alleviated the urolithiasis, renal insufficiency, and hypercalcemia.",True,"Is the triple 'Prednisolone treats hypercalcemia disease' supported by the sentence: 'Treatment with extracorporeal shock wave lithotripsy, transurethral lithotomy, saline infusion, and prednisolone (30 mg/day) alleviated the urolithiasis, renal insufficiency, and hypercalcemia.'?","Yes, the statement does provide indirect support for the phrase ""Prednisolone treats hypercalcemia disease"". The reason is that in the provided context, prednisolone is used as part of a treatment regimen for a patient suffering from urolithiasis, renal insufficiency, and hypercalcemia. The fact that these conditions were alleviated suggests that prednisolone might have contributed to improving hypercalcemia specifically, given that it is one of the mentioned treatments and hypercalcemia is explicitly listed among the conditions treated in this case. However, it is important to note that such an interpretation is based on an indirect inference since multiple treatments were administered concurrently, making it impossible to attribute the improvement solely to prednisolone without further investigation." -7603475,Prednisolone treats Duchenne muscular dystrophy,1182,A special program for long-term application of low-dose prednisolone treatment in Duchenne-Becker muscular dystrophy with complex control of the patients' state was developed.,True,Is the triple 'Prednisolone treats Duchenne muscular dystrophy' supported by the sentence: 'A special program for long-term application of low-dose prednisolone treatment in Duchenne-Becker muscular dystrophy with complex control of the patients' state was developed.'?,"Yes, indirectly it does lend some support. The statement mentions that a program for long-term application of low-dose prednisolone treatment was developed specifically for Duchenne-Becker muscular dystrophy. This suggests that prednisolone may have some therapeutic effect on Duchenne muscular dystrophy, given that it is being used as part of a treatment program for this condition. However, it's important to note that this doesn't necessarily mean that prednisolone alone treats Duchenne muscular dystrophy. The statement suggests that prednisolone is used as part of a complex treatment regimen, which implies that it may be one component of a larger treatment strategy rather than being an independent treatment for Duchenne muscular dystrophy." -7600829,Prednisolone treats multiple sclerosis,1183,"Long-term open-trial of mizoribine with prednisolone in 24 patients with multiple sclerosis: safety, clinical and magnetic resonance imaging outcome.",False,"Is the triple 'Prednisolone treats multiple sclerosis' supported by the sentence: 'Long-term open-trial of mizoribine with prednisolone in 24 patients with multiple sclerosis: safety, clinical and magnetic resonance imaging outcome.'?","No, the statement does not provide direct support for the claim that prednisolone treats multiple sclerosis. The study mentioned is an open-trial involving mizoribine and prednisolone in patients with multiple sclerosis, focusing on safety, clinical outcomes, and magnetic resonance imaging results. While prednisolone is part of the treatment regimen in this study, it does not necessarily imply that prednisolone alone is responsible for treating multiple sclerosis since it is used in combination with mizoribine in these patients. Additional studies focusing specifically on prednisolone as a treatment for multiple sclerosis would be required for more direct support for that claim." -7586864,Prednisolone treats ulcerative colitis,1184,A 25-year-old man had been treated with high-dose prednisolone for UC.,True,Is the triple 'Prednisolone treats ulcerative colitis' supported by the sentence: 'A 25-year-old man had been treated with high-dose prednisolone for UC.'?,"Yes, indirectly it does lend support to the claim that prednisolone treats ulcerative colitis (UC). The statement ""A 25-year-old man had been treated with high-dose prednisolone for UC"" implies that prednisolone was used as a treatment for UC in this particular case. However, it is important to note that while anecdotal evidence can suggest a trend, it does not definitively prove that prednisolone is an effective treatment for UC in all cases due to factors such as individual patient responses, dosage levels, duration of treatment, and potential side effects. Therefore, further clinical studies would be necessary for more robust support for this claim." -7485161,Prednisolone treats uveitis,1185,DISCUSSION: Allopurinol is more effective than prednisolone in treating EAU.,False,Is the triple 'Prednisolone treats uveitis' supported by the sentence: 'DISCUSSION: Allopurinol is more effective than prednisolone in treating EAU.'?,"No, the statement ""Allopurinol is more effective than prednisolone in treating EAU"" does not provide indirect support for the claim that ""Prednisolone treats uveitis."" In fact, it could be interpreted as suggesting that prednisolone might not be as effective in treating uveitis as another drug (in this case, allopurinol). However, it does not necessarily mean that prednisolone has no therapeutic effect on uveitis. It is important to note that uveitis is a complex condition with various forms and causes, so further investigation would be required to determine prednisolone's specific efficacy in treating uveitis." -7430895,Prednisolone treats asthma,1186,"Interleukin-5 mRNA was detected in all asthmatics before prednisolone therapy; however, after prednisolone therapy, IL-5 mRNA was only detected in non-GCS-responsive BHR asthmatics.",False,"Is the triple 'Prednisolone treats asthma' supported by the sentence: 'Interleukin-5 mRNA was detected in all asthmatics before prednisolone therapy; however, after prednisolone therapy, IL-5 mRNA was only detected in non-GCS-responsive BHR asthmatics.'?","No, the statement does not provide direct or indirect support for the phrase ""Prednisolone treats asthma."" The given statement discusses the presence of Interleukin-5 (IL-5) mRNA in asthmatics before and after prednisolone therapy, but it does not provide information about prednisolone's therapeutic effect on asthma symptoms or severity, which is essential for supporting the claim that prednisolone treats asthma." -7417999,Prednisolone treats IgA glomerulonephritis,1187,"Combined therapy with prednisolone, azathioprine, heparin-warfarin, and dipyridamole for paediatric patients with severe IgA nephropathy--is it relevant for adult patients?",False,"Is the triple 'Prednisolone treats IgA glomerulonephritis' supported by the sentence: 'Combined therapy with prednisolone, azathioprine, heparin-warfarin, and dipyridamole for paediatric patients with severe IgA nephropathy--is it relevant for adult patients?'?","No, the statement does not provide indirect support for the phrase ""Prednisolone treats IgA glomerulonephritis."" The original statement discusses combined therapy for paediatric patients with severe IgA nephropathy (a type of glomerulonephritis), which includes prednisolone as one component among others like azathioprine, heparin-warfarin, and dipyridamole. The focus is on treatment for severe IgA nephropathy in paediatric patients rather than specifically addressing IgA glomerulonephritis or adult patients. + Although the statement does not explicitly claim that hydrocortisone treats castration-resistant prostate carcinoma as a single agent, it does show that hydrocortisone is being used in therapeutic interventions for patients with HRPC who have progressed after initial hormone therapy. This usage suggests that hydrocortisone may play a role in managing HRPC symptoms or disease progression in combination therapy regimens. - To provide indirect support for ""Prednisolone treats IgA glomerulonephritis,"" there would need to be some connection drawn between prednisolone as an effective treatment for IgA glomerulonephritis in particular. The current statement does not establish such a connection explicitly or implicitly." -7158230,Prednisolone treats rheumatoid arthritis,1188,Remission of the nephrotic syndrome in a patient with renal amyloidosis due to rheumatoid arthritis treated with prednisolone and methotrexate.,True,Is the triple 'Prednisolone treats rheumatoid arthritis' supported by the sentence: 'Remission of the nephrotic syndrome in a patient with renal amyloidosis due to rheumatoid arthritis treated with prednisolone and methotrexate.'?,"Yes, there is indirect support for the claim that prednisolone treats rheumatoid arthritis in the statement provided. The nephrotic syndrome is a known complication of rheumatoid arthritis (RA), and its remission indicates an improvement in RA symptoms. The patient was treated with both prednisolone and methotrexate; therefore, we cannot attribute the remission solely to prednisolone. However, prednisolone is a glucocorticoid commonly used in RA treatment regimens due to its anti-inflammatory properties that help manage RA symptoms. Thus, it suggests that prednisolone has some therapeutic effect on RA in this specific case even though it was used in combination therapy." -23769275,Hydrocortisone treats leukemia,1189,"Study protocol: DexaDays-2, hydrocortisone for treatment of dexamethasone-induced neurobehavioral side effects in pediatric leukemia patients: a double-blind placebo controlled randomized intervention study with cross-over design.",False,"Is the triple 'Hydrocortisone treats leukemia' supported by the sentence: 'Study protocol: DexaDays-2, hydrocortisone for treatment of dexamethasone-induced neurobehavioral side effects in pediatric leukemia patients: a double-blind placebo controlled randomized intervention study with cross-over design.'?","No, the statement does not provide direct or indirect support for the claim that hydrocortisone treats leukemia. The study protocol focuses on using hydrocortisone as an intervention for dexamethasone-induced neurobehavioral side effects in pediatric leukemia patients. The primary objective here is managing side effects caused by dexamethasone treatment rather than treating leukemia itself using hydrocortisone. + However, it is important to note that more extensive clinical trials and direct evidence would be required for definitive proof of hydrocortisone's efficacy as a treatment for castration-resistant prostate carcinoma. The statement provided offers an insight into its use in treating HRPC but does not definitively establish hydrocortisone as a standalone treatment for" +7698304,Hydrocortisone treats otitis externa,1229,"Results of clinical trials indicate that ofloxacin otic solution 0.3% is as effective as topical neomycin/polymixin B/hydrocortisone preparations in the treatment of otitis externa (clinical cure rate >80% in adults and >95% in children for both treatments) and oral amoxicillin/clavulanic acid in the treatment of otitis media in the presence of tympanostomy tubes in children (clinical cure rates 76 and 69% for ofloxacin and amoxicillin/clavulanic acid, respectively).",False,"'Does the phrase ""Hydrocortisone treats otitis externa"" receive at least indirect support from the statement: ""Results of clinical trials indicate that ofloxacin otic solution 0.3% is as effective as topical neomycin/polymixin B/hydrocortisone preparations in the treatment of otitis externa (clinical cure rate >80% in adults and >95% in children for both treatments) and oral amoxicillin/clavulanic acid in the treatment of otitis media in the presence of tympanostomy tubes in children (clinical cure rates 76 and 69% for ofloxacin and amoxicillin/clavulanic acid, respectively).""?","No, the statement does not provide indirect support for the claim that ""Hydrocortisone treats otitis externa"". The statement discusses clinical trial results for ofloxacin otic solution 0.3% in treating otitis externa and otitis media in children with tympanostomy tubes. It mentions topical neomycin/polymixin B/hydrocortisone preparations as being effective in treating otitis externa, but it does not specifically attribute the effectiveness of these preparations to hydrocortisone alone. Therefore, it does not provide evidence that hydrocortisone is effective in treating otitis externa when used alone or as a standalone treatment option for otitis externa." +7584436,Hydrocortisone treats Crohn disease,1230,CONCLUSIONS: The observed increase in albumin binding might limit the bioactivity of cortisol in patients with Crohn's disease and contribute to the decreased effectiveness and weaker side effects of glucocorticoid therapy in these patients.,True,"'Does the phrase ""Hydrocortisone treats Crohn disease"" receive at least indirect support from the statement: ""CONCLUSIONS: The observed increase in albumin binding might limit the bioactivity of cortisol in patients with Crohn's disease and contribute to the decreased effectiveness and weaker side effects of glucocorticoid therapy in these patients.""?","Yes, indirectly. The statement does not explicitly mention hydrocortisone by name, but it does discuss glucocorticoid therapy, of which hydrocortisone is a type. The study suggests that in patients with Crohn's disease, there is an increase in albumin binding that might limit the bioactivity of cortisol (a type of glucocorticoid). This could potentially explain why glucocorticoid therapy is less effective in these patients (including hydrocortisone therapy), as less active cortisol would mean less anti-inflammatory effect. However, it's important to note that this is an indirect inference and further research would be needed to confirm this specific hypothesis." +7432481,Hydrocortisone treats pancreatitis,1231,"The amount of N-acetyl D-glucosamine in the zymogen granule membrane was not altered by caerulein acute pancreatitis induced under continuous hydrocortisone treatment, but it was decreased by the administration of L-364,718 over 7 days after pancreatitis induction.",False,"'Does the phrase ""Hydrocortisone treats pancreatitis"" receive at least indirect support from the statement: ""The amount of N-acetyl D-glucosamine in the zymogen granule membrane was not altered by caerulein acute pancreatitis induced under continuous hydrocortisone treatment, but it was decreased by the administration of L-364,718 over 7 days after pancreatitis induction.""?","No, the statement does not provide indirect support for the claim that ""Hydrocortisone treats pancreatitis."" The provided statement discusses the effects of hydrocortisone on N-acetyl D-glucosamine levels in zymogen granule membranes in relation to caerulein-induced acute pancreatitis in rats. It does not provide any information about the therapeutic effects of hydrocortisone on pancreatitis. Therefore, it does not support the claim that hydrocortisone treats pancreatitis." +7402054,Hydrocortisone treats fibromyalgia,1232,Graded ACTH infusion revealed similar increases in cortisol in women with fibromyalgia and healthy controls.,False,"'Does the phrase ""Hydrocortisone treats fibromyalgia"" receive at least indirect support from the statement: ""Graded ACTH infusion revealed similar increases in cortisol in women with fibromyalgia and healthy controls.""?","No, the statement does not provide indirect support for the claim that hydrocortisone treats fibromyalgia. The study mentioned measures cortisol levels in response to ACTH infusion in women with fibromyalgia and healthy controls. While hydrocortisone is a synthetic form of cortisol, the experiment does not demonstrate any direct link between hydrocortisone administration and fibromyalgia treatment. - To establish whether hydrocortisone can treat leukemia indirectly based on this study protocol, we would need evidence suggesting that addressing these neurobehavioral side effects can lead to better leukemia treatment outcomes in pediatric patients. However, since there is no mention of such evidence in the study protocol provided, we cannot infer that hydrocortisone has any indirect effect on leukemia treatment. + To provide indirect support for the claim that hydrocortisone treats fibromyalgia, one would need evidence showing that administering hydrocortisone results in improved fibromyalgia symptoms or related physiological changes specific to fibromyalgia patients. The current statement only demonstrates similar cortisol responses between fibromyalgia patients and healthy controls following ACTH infusion but does not provide information about hydrocortisone treatment for fibromyalgia." +7378370,Hydrocortisone treats chronic primary adrenal insufficiency,1233,The effects of endogenous opioids and cortisol on thyrotropin and prolactin secretion in patients with Addison's disease.,True,"'Does the phrase ""Hydrocortisone treats chronic primary adrenal insufficiency"" receive at least indirect support from the statement: ""The effects of endogenous opioids and cortisol on thyrotropin and prolactin secretion in patients with Addison's disease.""?","Yes, indirectly it does support the statement that hydrocortisone treats chronic primary adrenal insufficiency, also known as Addison's disease. The statement discusses the effects of endogenous opioids and cortisol on thyrotropin and prolactin secretion in patients with Addison's disease. Hydrocortisone is a synthetic form of cortisol, which is a hormone that is often deficient in individuals with Addison's disease. Therefore, hydrocortisone is commonly used as a treatment for this condition to replace the missing cortisol. While the statement does not explicitly mention hydrocortisone, it does discuss cortisol in relation to Addison's disease, which implies a connection to treatment options including hydrocortisone. However, it is important to note that this is an indirect inference based on general knowledge about Addison's disease and its treatment, rather than a direct conclusion drawn from the statement itself." +7363431,Hydrocortisone treats asthma,1234,[Dynamics of the cortisol content in the blood plasma in specific hyposensibilization in children with bronchial asthma].,False,"'Does the phrase ""Hydrocortisone treats asthma"" receive at least indirect support from the statement: ""[Dynamics of the cortisol content in the blood plasma in specific hyposensibilization in children with bronchial asthma].""?","No, the statement does not provide indirect support for the claim that ""Hydrocortisone treats asthma."" The statement ""Dynamics of the cortisol content in the blood plasma in specific hyposensibilization in children with bronchial asthma"" is discussing the dynamics of cortisol content in children with bronchial asthma undergoing specific hyposensibilization. Cortisol is a natural hormone produced by the adrenal gland that has anti-inflammatory effects, which can help reduce symptoms of asthma. However, hydrocortisone is a synthetic form of cortisol often used in medications. The statement provided does not mention hydrocortisone or any form of treatment, but rather discusses cortisol dynamics in a specific context. Therefore, it does not provide support for the claim that hydrocortisone treats asthma." +27127545,Methylprednisolone treats lymphoproliferative syndrome,1235,Treatment of X-linked lymphoproliferative disease (Duncan disease) with high-dose methylprednisolone and etoposide (VP-16).,True,"'Does the phrase ""Methylprednisolone treats lymphoproliferative syndrome"" receive at least indirect support from the statement: ""Treatment of X-linked lymphoproliferative disease (Duncan disease) with high-dose methylprednisolone and etoposide (VP-16).""?","Yes, the statement does provide indirect support for the phrase ""Methylprednisolone treats lymphoproliferative syndrome"". X-linked lymphoproliferative disease (XLP), also known as Duncan disease, is a primary immunodeficiency disorder that can present with lymphoproliferative syndrome as one of its complications. Lymphoproliferative syndrome is characterized by an uncontrolled proliferation of lymphocytes, which can lead to various clinical manifestations such as lymphoma and autoimmune diseases. - In summary, while hydrocortisone might have some impact on pediatric leukemia patients due to its potential influence on neurobehavioral side effects during dexamethasone treatment, there is no solid basis in the given study protocol for claiming that hydrocortisone treats leuk" -22345112,Hydrocortisone treats oral submucous fibrosis,1190,"Aims and Objective: To evaluate the efficacy of injection placentrex and injection hydrocortisone in oral submucous fibrosis patients in increasing mouth opening, burning sensation, and improve the mucosal lining.",True,"Is the triple 'Hydrocortisone treats oral submucous fibrosis' supported by the sentence: 'Aims and Objective: To evaluate the efficacy of injection placentrex and injection hydrocortisone in oral submucous fibrosis patients in increasing mouth opening, burning sensation, and improve the mucosal lining.'?","Yes, indirectly it does support the claim that hydrocortisone treats oral submucous fibrosis (OSF). The statement mentions an ""evaluation of the efficacy"" for injection hydrocortisone in OSF patients concerning increasing mouth opening, burning sensation alleviation, and mucosal lining improvement. By assessing its efficacy in treating these symptoms associated with OSF, one can infer that hydrocortisone has potential therapeutic benefits for OSF patients. However, it is essential to consider that indirect support does not equate to definitive proof, as further investigation would be required for stronger evidence-based conclusions regarding hydrocortisone's effectiveness in treating OSF." -22282269,Hydrocortisone treats Infection,1191,"The results presented herein imply that the three families of cyanine dyes, in particular compounds 5a-f, show high potential as selective scaffolds to treat C. albicans infections.",False,"Is the triple 'Hydrocortisone treats Infection' supported by the sentence: 'The results presented herein imply that the three families of cyanine dyes, in particular compounds 5a-f, show high potential as selective scaffolds to treat C. albicans infections.'?","No, the phrase ""Hydrocortisone treats Infection"" does not receive at least indirect support from the statement: ""The results presented herein imply that the three families of cyanine dyes, in particular compounds 5a-f, show high potential as selective scaffolds to treat C. albicans infections."" + The statement mentions that high-dose methylprednisolone, in combination with etoposide (VP-16), is used in the treatment of XLP. Methylprednisolone is a corticosteroid that possesses anti-inflammatory and immunosuppressive properties. By suppressing the immune system, corticosteroids like methylprednisolone can help control the unchecked proliferation of lymphocytes seen in lymphoproliferative syndrome. - The statement specifically refers to cyanine dyes, particularly compounds 5a-f, as having high potential for treating C. albicans infections. Hydrocortisone is not mentioned anywhere in the statement, nor is it implied as a treatment for any kind of infection. Therefore, there is no indirect support for the claim that hydrocortisone treats infection based on this statement." -21368080,Hydrocortisone treats lymphoma,1192,The serum cortisol concentration in the LYMPH patients was 285 +/- 74 nmol/l.,False,Is the triple 'Hydrocortisone treats lymphoma' supported by the sentence: 'The serum cortisol concentration in the LYMPH patients was 285 +/- 74 nmol/l.'?,"No, the statement ""The serum cortisol concentration in the LYMPH patients was 285 +/- 74 nmol/l"" does not provide indirect support for the claim that ""Hydrocortisone treats lymphoma."" This is because measuring serum cortisol levels in lymphoma patients does not inherently demonstrate that administering hydrocortisone (a synthetic form of cortisol) will result in therapeutic benefits for these patients. To establish indirect support for such a claim, there would need to be additional evidence showing that hydrocortisone has an impact on lymphoma progression, patient survival, or related outcomes in clinical settings. The provided statement only offers information about cortisol levels in lymphoma patients but does not explicitly link hydrocortisone treatment to any potential benefits for these patients." -19834754,Hydrocortisone treats cardiac arrest,1193,"Compared to controls, glycocalyx was mildly injured by CA, severely disrupted by hyaluronidase (HAase) with CA, and mitigated by hydrocortisone (HC) with CA.",False,"Is the triple 'Hydrocortisone treats cardiac arrest' supported by the sentence: 'Compared to controls, glycocalyx was mildly injured by CA, severely disrupted by hyaluronidase (HAase) with CA, and mitigated by hydrocortisone (HC) with CA.'?","No, the statement does not provide direct or indirect support for the claim that hydrocortisone treats cardiac arrest (CA). The provided information discusses the effects of hydrocortisone (HC) on glycocalyx in relation to hyaluronidase (HAase) and cardiac arrest; however, it does not establish a causal relationship between hydrocortisone administration and improvements in cardiac arrest outcomes. Further investigation and evidence would be required to make such a claim." -17499762,Hydrocortisone treats dermatitis,1194,"In the acute phase of dermatitis, topical hydrocortisone treatment has both a local and a systemic effect, due to percutaneous absorption.",True,"Is the triple 'Hydrocortisone treats dermatitis' supported by the sentence: 'In the acute phase of dermatitis, topical hydrocortisone treatment has both a local and a systemic effect, due to percutaneous absorption.'?","Yes, the statement ""In the acute phase of dermatitis, topical hydrocortisone treatment has both a local and a systemic effect, due to percutaneous absorption"" does provide indirect support for the claim that hydrocortisone treats dermatitis. The key phrase here is ""topical hydrocortisone treatment,"" which implies that hydrocortisone is being used as a therapeutic agent for dermatitis. The statement also mentions that hydrocortisone has both local (presumably at the site of application on the skin) and systemic effects (throughout the body), suggesting that it can indeed have an impact on dermatitis symptoms. However, it is important to note that while this statement supports the efficacy of hydrocortisone in treating dermatitis, it does not necessarily confirm that hydrocortisone is the best or only treatment option available for dermatitis." -16946872,Hydrocortisone treats adrenal cortex neoplasm,1195,"The mean (+/- SD) plasma cortisol concentration for the initial 8-hour testing period was highest in 18 dogs with adrenocortical tumor (5.3 +/- 1.6 micrograms/dl), lowest in 15 control dogs (1.3 +/- 0.5 micrograms/dl), and intermediate in 31 dogs with pituitary-dependent hyperadrenocorticism (PDH; 3.4 +/- 1.2 micrograms/dl).",False,"Is the triple 'Hydrocortisone treats adrenal cortex neoplasm' supported by the sentence: 'The mean (+/- SD) plasma cortisol concentration for the initial 8-hour testing period was highest in 18 dogs with adrenocortical tumor (5.3 +/- 1.6 micrograms/dl), lowest in 15 control dogs (1.3 +/- 0.5 micrograms/dl), and intermediate in 31 dogs with pituitary-dependent hyperadrenocorticism (PDH; 3.4 +/- 1.2 micrograms/dl).'?","No, the statement does not provide direct support for the phrase ""Hydrocortisone treats adrenal cortex neoplasm"". The statement presents data on plasma cortisol concentrations in dogs with different conditions, including adrenocortical tumor, pituitary-dependent hyperadrenocorticism (PDH), and control dogs. However, it does not mention hydrocortisone or its therapeutic effects on adrenal cortex neoplasm. + Therefore, even though the statement does not explicitly state that methylpred" +26450412,Methylprednisolone treats leukemia,1236,"Circadian optimization of the treatment of L1210 leukemia with 1-beta-D-arabinofuranosylcytosine, cyclophosphamide, vincristine and methylprednisolone.",True,"'Does the phrase ""Methylprednisolone treats leukemia"" receive at least indirect support from the statement: ""Circadian optimization of the treatment of L1210 leukemia with 1-beta-D-arabinofuranosylcytosine, cyclophosphamide, vincristine and methylprednisolone.""?","Yes, while the statement does not explicitly claim that methylprednisolone treats leukemia on its own, it does imply that methylprednisolone is used in combination with other treatments for L1210 leukemia. This suggests that methylprednisolone may have some therapeutic benefit in treating leukemia, even if it is not effective as a standalone treatment. However, it is important to note that this interpretation is based on indirect evidence and further research would be needed to confirm the specific efficacy of methylprednisolone in treating leukemia. It is also crucial to consider that many cancer treatments involve combinations of drugs to target different aspects of the disease, so finding a drug in such a combination does not necessarily mean it would be effective on its own." +26339812,Methylprednisolone treats alcoholic hepatitis,1237,Controlled trial of methylprednisolone therapy in severe acute alcoholic hepatitis.,True,"'Does the phrase ""Methylprednisolone treats alcoholic hepatitis"" receive at least indirect support from the statement: ""Controlled trial of methylprednisolone therapy in severe acute alcoholic hepatitis.""?","Yes, the statement ""Controlled trial of methylprednisolone therapy in severe acute alcoholic hepatitis"" does lend indirect support to the claim that methylprednisolone treats alcoholic hepatitis. This is because it suggests that there has been some form of clinical investigation into the effects of methylprednisolone specifically in the context of severe acute alcoholic hepatitis. - To provide indirect support for the claim, there should be some connection between hydrocortisone and adrenal cortex neoplasm in the statement. For example, if it mentioned that hydrocortisone was used to treat dogs with adrenal cortex neoplasm and resulted in decreased cortisol levels, then it would provide indirect support for the claim. Nonetheless, without such information, it is not possible to infer any relationship between hydrocortisone and adrenal cortex neoplasm from the given statement." -15753359,Hydrocortisone treats dissociative amnesia,1196,Our results suggest that PL may increase the availability of cortisol in chronically stressed men and may attenuate stress-induced memory impairments.,False,Is the triple 'Hydrocortisone treats dissociative amnesia' supported by the sentence: 'Our results suggest that PL may increase the availability of cortisol in chronically stressed men and may attenuate stress-induced memory impairments.'?,"No, the phrase ""Hydrocortisone treats dissociative amnesia"" does not receive indirect support from the statement: ""Our results suggest that PL may increase the availability of cortisol in chronically stressed men and may attenuate stress-induced memory impairments."" + However, it is important to note that a controlled trial does not necessarily equate to a positive outcome or efficacy of treatment. The results of such a trial would need to be examined in order to make a more definitive conclusion about the effectiveness of methylprednisolone for treating alcoholic hepatitis. Additionally, terms like ""severe"" and ""acute"" can influence the interpretation of results, as alcoholic hepatitis can present in various forms and stages of progression. - The statement refers to a study involving PL (presumably a drug or intervention) and its effects on cortisol availability in chronically stressed men, as well as potential benefits for stress-induced memory impairments. However, hydrocortisone is not mentioned in the statement; it is a synthetic form of cortisol used primarily for replacing deficient cortisol in patients with adrenal insufficiency rather than treating dissociative amnesia specifically. + Therefore, while the statement does provide some level of support for the claim, it is not definitive proof of methylprednisolone's effectiveness in treating alcoholic hepatitis. Further investigation into the specifics of the trial, including its design, results, and any subsequent publications, would be" +26307075,Methylprednisolone treats psoriatic arthritis,1238,"1 The present study was undertaken to characterize the spectrum of arachidonic acid metabolites present in synovial effusions of patients with rheumatoid or psoriatic arthritis, and to compare changes in their concentration following a short-term treatment with 6alpha-methyl-prednisolone (6-MeP: 4-8 mg/day) or indoprofen (1.2 g/day), a nonsteroidal anti-inflammatory agent with proven synovial prostaglandin inhibitory effect.2 Measurements of prostaglandin E(2) (PGE(2)), thromboxane (TX) B(2), 6-keto-PGF(1alpha) and PGF(2alpha) were performed by radioimmunoassay techniques in synovial effusions obtained from 23 patients, and validated by thin-layer chromatographic analysis of the extracted immunoreactivity.3 PGE(2) and TXB(2) accounted for more than 60% of the total immunoreactivity in untreated patients.",False,"'Does the phrase ""Methylprednisolone treats psoriatic arthritis"" receive at least indirect support from the statement: ""1 The present study was undertaken to characterize the spectrum of arachidonic acid metabolites present in synovial effusions of patients with rheumatoid or psoriatic arthritis, and to compare changes in their concentration following a short-term treatment with 6alpha-methyl-prednisolone (6-MeP: 4-8 mg/day) or indoprofen (1.2 g/day), a nonsteroidal anti-inflammatory agent with proven synovial prostaglandin inhibitory effect.2 Measurements of prostaglandin E(2) (PGE(2)), thromboxane (TX) B(2), 6-keto-PGF(1alpha) and PGF(2alpha) were performed by radioimmunoassay techniques in synovial effusions obtained from 23 patients, and validated by thin-layer chromatographic analysis of the extracted immunoreactivity.3 PGE(2) and TXB(2) accounted for more than 60% of the total immunoreactivity in untreated patients.""?","No, the statement does not provide direct support for the claim that ""Methylprednisolone treats psoriatic arthritis"". The study mentioned primarily focuses on characterizing arachidonic acid metabolites in synovial effusions of patients with rheumatoid or psoriatic arthritis before and after treatment with Methylprednisolone (6-MeP) or indoprofen. The fact that PGE(2) and TXB(2)" +26279366,Methylprednisolone treats angioimmunoblastic T-cell lymphoma,1239,Pulse methylprednisolone therapy in angioimmunoblastic lymphadenopathy.,True,"'Does the phrase ""Methylprednisolone treats angioimmunoblastic T-cell lymphoma"" receive at least indirect support from the statement: ""Pulse methylprednisolone therapy in angioimmunoblastic lymphadenopathy.""?","Yes, there is indirect support for the phrase ""Methylprednisolone treats angioimmunoblastic T-cell lymphoma"" from the statement ""Pulse methylprednisolone therapy in angioimmunoblastic lymphadenopathy."" - Furthermore, dissociative amnesia is not explicitly addressed in the statement; stress-induced memory impairments do not necessarily equate to dissociative amnesia as dissociative amnesia is characterized by gaps in memory that cannot be explained by ordinary forgetfulness and is often linked to traumatic experiences. + The key term here is ""angioimmunoblastic lymphadenopathy,"" which is a characteristic feature of angioimmunoblastic T-cell lymphoma (AITL). AITL is a type of non-Hodgkin lymphoma that often presents with generalized lymphadenopathy, hepatosplenomegaly, skin rash, polyclonal hypergammaglobulinemia, and autoimmune phenomena. - Therefore, without further information linking hydrocortisone, PL (if indeed PL is hydroc" -15602187,Hydrocortisone treats Hypoxemia,1197,All inhibitors prevented the rise in cortisol secretion usually observed in hypoxic dogs.,False,Is the triple 'Hydrocortisone treats Hypoxemia' supported by the sentence: 'All inhibitors prevented the rise in cortisol secretion usually observed in hypoxic dogs.'?,"No, the statement ""All inhibitors prevented the rise in cortisol secretion usually observed in hypoxic dogs"" does not provide direct or indirect support for the claim ""Hydrocortisone treats Hypoxemia."" + The statement suggests that methylprednisolone is used in pulse therapy for angioimmunoblastic lymphadenopathy. Methylprednisolone is a corticosteroid often used in cancer treatment due to its anti-inflammatory and immunosuppressive properties. Therefore, it can be inferred that methylprednisol" +25738014,Methylprednisolone treats ankylosing spondylitis,1240,Seven patients with active AS and insufficient efficacy of NSAID for three months were treated with one gram methylprednisolone daily given intravenously for three successive days.,True,"'Does the phrase ""Methylprednisolone treats ankylosing spondylitis"" receive at least indirect support from the statement: ""Seven patients with active AS and insufficient efficacy of NSAID for three months were treated with one gram methylprednisolone daily given intravenously for three successive days.""?","Yes, the statement does provide indirect support for the claim that methylprednisolone treats ankylosing spondylitis (AS). The statement describes seven patients with active AS who were treated with methylprednisolone for three consecutive days due to insufficient efficacy of NSAIDs for three months. The fact that methylprednisolone was administered as a treatment suggests that it has some therapeutic effect on AS, even if it is not explicitly stated in the text provided. However, it is important to note that indirect support does not equate to definitive proof of efficacy; further studies would need to be conducted in order to establish methylprednisolone as an effective treatment for AS." +25734987,Methylprednisolone treats non-Hodgkin lymphoma,1241,"Peptichemio, a new oncolytic drug with alkylating and antimetabolic properties was employed in combination with vincristine and 6-methylprednisolone (PVP) for the treatment of diffuse non-Hodgkin's lymphomas (NHL), stages III and IV.",True,"'Does the phrase ""Methylprednisolone treats non-Hodgkin lymphoma"" receive at least indirect support from the statement: ""Peptichemio, a new oncolytic drug with alkylating and antimetabolic properties was employed in combination with vincristine and 6-methylprednisolone (PVP) for the treatment of diffuse non-Hodgkin's lymphomas (NHL), stages III and IV.""?","Yes, indirect support can be inferred from the statement. The claim that methylprednisolone treats non-Hodgkin lymphoma is not explicitly stated in the provided context, but it does imply that 6-methylprednisolone was used as part of a treatment regimen for diffuse non-Hodgkin's lymphomas (NHL), stages III and IV. This suggests that methylprednisolone may have contributed to the treatment effect, providing indirect support for its use in treating non-Hodgkin lymphoma. However, it is important to note that methylprednisolone was used in combination with other drugs (Peptichemio and vincristine), making it difficult to attribute the treatment effect solely to methylprednisolone. Additionally, further research would be needed to establish the specific therapeutic role of methylprednisolone in non-Hodgkin lymphoma treatment regimens." +25642231,Methylprednisolone treats heart disorder,1242,High-dose MP may be contraindicated in patients with known heart disease.,True,"'Does the phrase ""Methylprednisolone treats heart disorder"" receive at least indirect support from the statement: ""High-dose MP may be contraindicated in patients with known heart disease.""?","Yes, indirectly it does lend some support. The statement ""High-dose MP may be contraindicated in patients with known heart disease"" implies that Methylprednisolone (MP) has an effect on heart disease, and that effect is negative when used in high doses. This suggests that MP does interact with heart disorders in some capacity, even if the interaction is not necessarily therapeutic. However, it's important to note that this doesn't necessarily mean MP ""treats"" heart disorders; it could also mean it exacerbates them or has other negative impacts on heart health. Further research would be needed to clarify these points." +25366540,Methylprednisolone treats myopathy,1243,PURPOSE: To report the therapeutic efficacy of intravenous methylprednisolone (IVMP) in patients with restrictive myopathy caused by thyroid eye disease (TED).,True,"'Does the phrase ""Methylprednisolone treats myopathy"" receive at least indirect support from the statement: ""PURPOSE: To report the therapeutic efficacy of intravenous methylprednisolone (IVMP) in patients with restrictive myopathy caused by thyroid eye disease (TED).""?","Yes, the statement does provide indirect support for the phrase ""Methylprednisolone treats myopathy"". The purpose of the study is to report the therapeutic efficacy of intravenous methylprednisolone (IVMP) in patients with restrictive myopathy caused by thyroid eye disease (TED). This implies that methylprednisolone was used as a treatment for myopathy in this specific context, thus providing indirect evidence that methylprednisolone can be used to treat myopathy. However, it is important to note that myopathy is a broad term used to describe muscle diseases, and the efficacy of methylprednisolone may vary depending on the specific type of myopathy. Therefore, while the statement supports the idea that methylprednisolone can treat myopathy, it does not necessarily mean that it is effective for all types of myopathy." +24273559,Methylprednisolone treats Abdominal pain,1244,"After 2 months of treatment with systemic methylprednisolone, cyclophosphamide, and prednisone, the patient's abdominal pain was relieved.",True,"'Does the phrase ""Methylprednisolone treats Abdominal pain"" receive at least indirect support from the statement: ""After 2 months of treatment with systemic methylprednisolone, cyclophosphamide, and prednisone, the patient's abdominal pain was relieved.""?","Yes, indirect support can be inferred from the statement. The relief of abdominal pain in the patient after two months of treatment that includes methylprednisolone suggests a potential connection between the drug and abdominal pain relief. However, it is important to note that methylprednisolone was not administered alone; it was part of a combination therapy involving cyclophosphamide and prednisone. Therefore, it cannot be definitively concluded that methylprednisolone solely treated the abdominal pain. Other factors such as the potential synergistic effects of the combined drugs, individual patient response, and disease characteristics could have contributed to the pain relief. Further investigation through controlled clinical trials would be necessary for more direct support of the claim that methylprednisolone treats abdominal pain." +23772707,Methylprednisolone treats cardiac arrest,1245,Effect of Vasopressin and Methylprednisolone vs Placebo on Return of Spontaneous Circulation in Patients With In-Hospital Cardiac Arrest: A Randomized Clinical Trial.,True,"'Does the phrase ""Methylprednisolone treats cardiac arrest"" receive at least indirect support from the statement: ""Effect of Vasopressin and Methylprednisolone vs Placebo on Return of Spontaneous Circulation in Patients With In-Hospital Cardiac Arrest: A Randomized Clinical Trial.""?","Yes, indirectly. The title of the study ""Effect of Vasopressin and Methylprednisolone vs Placebo on Return of Spontaneous Circulation in Patients With In-Hospital Cardiac Arrest: A Randomized Clinical Trial"" does suggest that methylprednisolone is being tested for its effect on cardiac arrest. However, it does not confirm that methylprednisolone treats cardiac arrest as the study could have found that it has no effect or even a negative effect. Furthermore, without access to the full text of the study, we cannot evaluate the specifics of how methylprednisolone was administered, the population studied, and other factors that could influence its efficacy in treating cardiac arrest. Therefore, while there is some indirect support for the idea that methylprednisolone may have a role in treating cardiac arrest based on this title, it is not definitive proof." +23209303,Methylprednisolone treats respiratory system disorder,1246,"Although methylprednisolone gradually improved her respiratory condition, her oxygenation and exercise tolerance had drastically deteriorated, necessitating high-flow nasal cannula oxygen therapy.",False,"'Does the phrase ""Methylprednisolone treats respiratory system disorder"" receive at least indirect support from the statement: ""Although methylprednisolone gradually improved her respiratory condition, her oxygenation and exercise tolerance had drastically deteriorated, necessitating high-flow nasal cannula oxygen therapy.""?","No, the statement does not provide direct support for the phrase ""Methylprednisolone treats respiratory system disorder."" The statement indicates that methylprednisolone improved her respiratory condition gradually, but it also mentions that her oxygenation and exercise tolerance deteriorated significantly, requiring high-flow nasal cannula oxygen therapy. This suggests that while methylprednisolone may have had some positive effect on the patient's respiratory system, it did not completely treat the disorder, as the patient still required additional oxygen therapy. Therefore, it would be inaccurate to draw a definitive conclusion of treatment based solely on this statement." +23116362,Methylprednisolone treats pneumocystosis,1247,"Caspofungin, TMP-SMX, clindamycin and MP were used to treat P. jirovecii pneumonia (PJP).",True,"'Does the phrase ""Methylprednisolone treats pneumocystosis"" receive at least indirect support from the statement: ""Caspofungin, TMP-SMX, clindamycin and MP were used to treat P. jirovecii pneumonia (PJP).""?","Yes, the statement ""Methylprednisolone (MP) was used to treat P. jirovecii pneumonia (PJP)"" does provide indirect support for the claim ""Methylprednisolone treats pneumocystosis."" Pneumocystosis is an infection caused by Pneumocystis jirovecii, which is often referred to as PCP (Pneumocystis carinii pneumonia). Methylprednisolone is frequently used in combination therapy for treating PJP because it helps manage inflammation associated with PJP infections. - The original statement discusses how ""all inhibitors"" prevent an increase in cortisol secretion in hypoxic dogs, which is not explicitly related to hydrocortisone treating hypoxemia (low oxygen levels in blood). Hydrocortisone is a steroid hormone that is often used as an anti-inflammatory agent; it is not typically considered an ""inhibitor"" in terms used in hypoxia research. + However, it is essential to clarify that Methylprednisolone is not an antimicrobial agent itself but rather an adjunct therapy for controlling inflammation during PJP infections. The primary antimicrobial agents used for treating PJP include Caspofungin, TMP-SMX (trimethoprim-sulfamethoxazole), and clindamycin as mentioned in the provided statement. Therefore, while Methylprednisolone does have an essential role in managing PJP infections, it is not" +22495912,Methylprednisolone treats myocarditis,1248,"Although, not described in the literature, we have found conjunctive use of milrinone and methylprednisolone effective in patient with SARS-CoV-2 fulminant myocarditis.",True,"'Does the phrase ""Methylprednisolone treats myocarditis"" receive at least indirect support from the statement: ""Although, not described in the literature, we have found conjunctive use of milrinone and methylprednisolone effective in patient with SARS-CoV-2 fulminant myocarditis.""?","Yes, the statement does provide indirect support for the phrase ""Methylprednisolone treats myocarditis."" The statement suggests that methylprednisolone has been used in conjunction with milrinone to treat a patient with SARS-CoV-2 fulminant myocarditis, which is a form of myocarditis. However, it is important to note that this is an anecdotal observation from a single case, not a controlled clinical study. Therefore, while it suggests potential benefits, it does not provide definitive evidence of methylprednisolone's effectiveness in treating myocarditis. Further studies are needed to confirm these observations and establish methylprednisolone as a standard treatment for myocarditis." +19962298,Methylprednisolone treats Hodgkins lymphoma,1249,High incidence of aseptic hip necrosis in Hodgkin lymphoma patients treated with escalated BEACOPP receiving methylprednisolone.,False,"'Does the phrase ""Methylprednisolone treats Hodgkins lymphoma"" receive at least indirect support from the statement: ""High incidence of aseptic hip necrosis in Hodgkin lymphoma patients treated with escalated BEACOPP receiving methylprednisolone.""?","No, the statement does not provide indirect support for the claim that ""Methylprednisolone treats Hodgkin lymphoma."" The statement you provided discusses the high incidence of aseptic hip necrosis in Hodgkin lymphoma patients treated with escalated BEACOPP (a chemotherapy regimen) who receive methylprednisolone as part of their treatment plan. - In order for us to assess if hydrocortisone could treat hypoxemia, we would need evidence that specifically addresses hydrocortisone administration in hypoxemic conditions and its impact on oxygenation levels in animals or humans. The provided statement does not offer such evidence; thus, it does not support the claim that hydrocortisone treats hypoxemia." -15325707,Hydrocortisone treats psoriasis,1198,"The expression of StAR and MLN64 was aberrant in two skin disorders, psoriasis and atopic dermatitis, that are commonly treated with cortisol, suggesting dysregulation of epidermal steroid synthesis in these patients.",False,"Is the triple 'Hydrocortisone treats psoriasis' supported by the sentence: 'The expression of StAR and MLN64 was aberrant in two skin disorders, psoriasis and atopic dermatitis, that are commonly treated with cortisol, suggesting dysregulation of epidermal steroid synthesis in these patients.'?","No, the statement does not provide direct or indirect support for the phrase ""Hydrocortisone treats psoriasis."" The statement discusses aberrant expression of StAR and MLN64 in psoriasis and atopic dermatitis, which implies dysregulation of epidermal steroid synthesis in these patients. However, it does not mention hydrocortisone specifically nor does it provide evidence that hydrocortisone is an effective treatment for psoriasis. Hydrocortisone is a type of corticosteroid, but different corticosteroids have different properties and may not all be equally effective for treating psoriasis. Therefore, while it is possible that hydrocortisone could be used to treat psoriasis, this statement does not provide evidence for that claim." -15213238,Hydrocortisone treats herpes labialis,1199,"ME-609 (Xerese, Xerclear) is a combination of 5% acyclovir and 1% hydrocortisone developed for the topical treatment of HSL.",False,"Is the triple 'Hydrocortisone treats herpes labialis' supported by the sentence: 'ME-609 (Xerese, Xerclear) is a combination of 5% acyclovir and 1% hydrocortisone developed for the topical treatment of HSL.'?","No, the statement does not provide direct or indirect support for the claim that ""Hydrocortisone treats herpes labialis."" While it is true that ME-609 is a topical treatment for Herpes Labialis Simplex (HSL) containing 1% hydrocortisone, it does not imply that hydrocortisone alone is responsible for treating HSL. Furthermore, even if hydrocortisone had an effect on HSL, it would not necessarily mean that it treats herpes labialis as treating an infection implies causality and complete resolution which cannot be inferred from this statement alone." -14532907,Hydrocortisone treats cirrhosis of liver,1200,The urinary ratio of 6 beta-hydroxycortisol/cortisol (6 beta-OHC/C) as a biomarker of CYP3A4 metabolizing activity has been studied in Egyptian patients with chronic liver cirrhosis associated with previous hepatic Schistosomiasis infection to determine any possible alteration in enzyme activity.,False,Is the triple 'Hydrocortisone treats cirrhosis of liver' supported by the sentence: 'The urinary ratio of 6 beta-hydroxycortisol/cortisol (6 beta-OHC/C) as a biomarker of CYP3A4 metabolizing activity has been studied in Egyptian patients with chronic liver cirrhosis associated with previous hepatic Schistosomiasis infection to determine any possible alteration in enzyme activity.'?,"No, the statement does not provide indirect support for the claim that hydrocortisone treats cirrhosis of the liver. The statement discusses a study on Egyptian patients with chronic liver cirrhosis associated with previous hepatic Schistosomiasis infection, focusing on the urinary ratio of 6 beta-hydroxycortisol/cortisol (6 beta-OHC/C) as a biomarker for CYP3A4 metabolizing activity. While it is true that hydrocortisone is metabolized by CYP3A4 enzymes in the liver, there is no mention of hydrocortisone being used as a treatment for cirrhosis in this study or statement. Therefore, it does not provide any evidence or support for that specific claim." -14075841,Hydrocortisone treats acute lymphoblastic leukemia,1201,"Here, we report a case of fatal ATLS complicating intrathecal injections of methotrexate, cytarabine and hydrocortisone for acute lymphoblastic leukemia which relapsed with meningeal involvement after allogeneic stem cell transplantation.",False,"Is the triple 'Hydrocortisone treats acute lymphoblastic leukemia' supported by the sentence: 'Here, we report a case of fatal ATLS complicating intrathecal injections of methotrexate, cytarabine and hydrocortisone for acute lymphoblastic leukemia which relapsed with meningeal involvement after allogeneic stem cell transplantation.'?","No, the statement does not provide indirect support for the claim that ""Hydrocortisone treats acute lymphoblastic leukemia."" The statement reports a case where hydrocortisone was used in combination with other drugs for treating acute lymphoblastic leukemia (ALL) that had relapsed with meningeal involvement after allogeneic stem cell transplantation. The use of hydrocortisone in this context is for managing complications associated with ALL rather than treating ALL itself. The misconception arises due to conflating treating complications associated with ALL and treating ALL itself." -13951019,Hydrocortisone treats HIV infectious disease,1202,"Except in one patient with HIV infection, all the signs and symptoms improved after antituberculous and hydrocortisone treatment.",False,"Is the triple 'Hydrocortisone treats HIV infectious disease' supported by the sentence: 'Except in one patient with HIV infection, all the signs and symptoms improved after antituberculous and hydrocortisone treatment.'?","No, the phrase ""Hydrocortisone treats HIV infectious disease"" does not receive direct or indirect support from the statement: ""Except in one patient with HIV infection, all the signs and symptoms improved after antituberculous and hydrocortisone treatment."" + The presence of side effects (aseptic hip necrosis) does not imply that a treatment is effective for treating the condition it is meant for (Hodgkin lymphoma). In fact, it may indicate an increased risk of complications associated with that specific treatment regimen (escalated BEACOPP plus methylprednisolone). - The statement indicates that hydrocortisone treatment was associated with improvement in signs and symptoms in patients receiving antituberculous therapy, except for one patient who had HIV infection. This suggests that hydrocortisone may have had an effect on tuberculosis symptoms in most patients; however, it does not provide evidence that hydrocortisone is responsible for treating HIV infectious disease itself. + Therefore, it is important not to draw conclusions about treatment efficacy based solely on side effect profiles but rather on direct evidence from clinical trials designed to assess treatment efficacy in addressing Hodgkin lymphoma." +19674675,Methylprednisolone treats microscopic polyangiitis,1250,Six newly diagnosed patients with MPA were initially treated with methylprednisolone and a single dose of RTX (375 mg/m2).,True,"'Does the phrase ""Methylprednisolone treats microscopic polyangiitis"" receive at least indirect support from the statement: ""Six newly diagnosed patients with MPA were initially treated with methylprednisolone and a single dose of RTX (375 mg/m2).""?","Yes, indirectly it does support that methylprednisolone treats microscopic polyangiitis (MPA). The statement mentions that six newly diagnosed patients with MPA were initially treated with methylprednisolone in combination with Rituximab (RTX). This implies that methylprednisolone was used as part of the treatment regimen for MPA patients, suggesting its use for treating MPA. However, it should be noted that this is an indirect inference since it does not explicitly demonstrate methylprednisolone's efficacy as a standalone treatment for MPA nor does it account for potential confounding factors such as other treatments or individual patient differences that may have influenced outcomes." +19534575,Methylprednisolone treats anterior ischemic optic neuropathy,1251,Early Methylprednisolone Treatment Can Stabilize the Blood-Optic Nerve Barrier in a Rat Model of Anterior Ischemic Optic Neuropathy (rAION).,True,"'Does the phrase ""Methylprednisolone treats anterior ischemic optic neuropathy"" receive at least indirect support from the statement: ""Early Methylprednisolone Treatment Can Stabilize the Blood-Optic Nerve Barrier in a Rat Model of Anterior Ischemic Optic Neuropathy (rAION).""?","Yes, the statement does provide indirect support for the claim that methylprednisolone treats anterior ischemic optic neuropathy (AION). The study in rats demonstrates that early treatment with methylprednisolone can stabilize the blood-optic nerve barrier in rAION. This finding suggests that methylprednisolone has neuroprotective effects in AION pathology by potentially reducing inflammation and edema around the optic nerve head. - Therefore, it is inappropriate to infer that hydrocortisone has any therapeutic effect on HIV infection based on the given statement alone. Further investigation is required through controlled clinical trials specifically designed to test hydrocortisone as an intervention for HIV infection before such conclusions can be drawn." -13724762,Hydrocortisone treats severe acute respiratory syndrome,1203,"Cortisol levels are elevated in patients with RSV and Ebola, and cortisol was higher in SARS patients with lymphopenia before any steroid therapy.",False,"Is the triple 'Hydrocortisone treats severe acute respiratory syndrome' supported by the sentence: 'Cortisol levels are elevated in patients with RSV and Ebola, and cortisol was higher in SARS patients with lymphopenia before any steroid therapy.'?","No, the statement does not provide indirect support for the claim that hydrocortisone treats severe acute respiratory syndrome (SARS). The statement highlights that cortisol levels are elevated in patients suffering from respiratory syncytial virus (RSV), Ebola, and SARS (with lymphopenia). However, it does not provide any information on whether administering hydrocortisone (a synthetic form of cortisol) would have any therapeutic effects on SARS patients. + However, it is important to note that while this preclinical evidence is promising, it does not definitively establish that methylprednisolone is an effective treatment for human patients with AION. Further clinical studies in humans are required to confirm whether methylprednisolone has similar therapeutic effects in people suffering from AION. - To provide indirect support for the original claim, there would need to be some connection between cortisol/hydrocortisone administration and an improvement in SARS symptoms, which is not mentioned in the given statement. Therefore, more evidence is required before accepting that hydrocortisone could be an effective treatment for SARS based on cortisol level observations alone." -13691671,Hydrocortisone treats Insulin resistance,1204,OBJECTIVE: To investigate possible effects of insulin-sensitizing treatment on cortisol metabolism in insulin-resistant patients with polycystic ovary syndrome (PCOS).,False,Is the triple 'Hydrocortisone treats Insulin resistance' supported by the sentence: 'OBJECTIVE: To investigate possible effects of insulin-sensitizing treatment on cortisol metabolism in insulin-resistant patients with polycystic ovary syndrome (PCOS).'?,"No, the statement does not provide direct support for the phrase ""Hydrocortisone treats Insulin resistance."" The objective in the statement is focused on investigating possible effects of insulin-sensitizing treatment on cortisol metabolism in insulin-resistant patients with polycystic ovary syndrome (PCOS). Hydrocortisone is a glucocorticoid hormone and not an insulin-sensitizing agent. Even though it may have some indirect relationship through its impact on cortisol metabolism, it does not directly treat insulin resistance based on the information provided in the statement alone." -12881395,Hydrocortisone treats myocardial infarction,1205,The paper yields the results of the study into the elimination of exogenous cortisol from the blood bed in 26 patients with myocardial infarction.,False,Is the triple 'Hydrocortisone treats myocardial infarction' supported by the sentence: 'The paper yields the results of the study into the elimination of exogenous cortisol from the blood bed in 26 patients with myocardial infarction.'?,"No, the statement does not provide indirect support for the claim that hydrocortisone treats myocardial infarction. The study mentioned in the statement investigates the elimination of exogenous cortisol from the blood bed in patients with myocardial infarction, but it does not mention hydrocortisone specifically. Cortisol is a naturally occurring hormone in the human body, while hydrocortisone is a synthetic form of cortisol used in medications for various conditions. Therefore, we cannot infer that hydrocortisone is being used in this study based solely on the provided information. + In summary, although the statement does not explicitly confirm that methylprednisolone treats AION in humans, it does provide indirect support by demonstrating beneficial effects in an animal model of rAION, which warrants further investigation in clinical settings." +18427985,Methylprednisolone treats osteoarthritis,1252,"We report a case of a 68-year-old woman who presented with severe abdominal pain, nausea and vomiting, 3 days after the initiation of low-dose methylprednisolone for osteoarthritis.",False,"'Does the phrase ""Methylprednisolone treats osteoarthritis"" receive at least indirect support from the statement: ""We report a case of a 68-year-old woman who presented with severe abdominal pain, nausea and vomiting, 3 days after the initiation of low-dose methylprednisolone for osteoarthritis.""?","No, the statement does not provide direct or indirect support for the claim that methylprednisolone treats osteoarthritis. The case report describes an adverse reaction experienced by a patient who had initiated low-dose methylprednisolone for osteoarthritis treatment. It does not discuss the therapeutic benefits of methylprednisolone for osteoarthritis; rather, it highlights an unfortunate side effect associated with its use in this particular patient. It is essential to differentiate between potential side effects and therapeutic effects when interpreting such evidence in order to maintain accuracy in our understanding of medical treatments." +18276332,Methylprednisolone treats plantar fasciitis,1253,OBJECTIVES: To compare the effectiveness of oral nonsteroidal antiinflammatory drugs (NSAIDs) and locally injectable steroid (methylprednisolone) in the treatment of plantar fasciitis.,True,"'Does the phrase ""Methylprednisolone treats plantar fasciitis"" receive at least indirect support from the statement: ""OBJECTIVES: To compare the effectiveness of oral nonsteroidal antiinflammatory drugs (NSAIDs) and locally injectable steroid (methylprednisolone) in the treatment of plantar fasciitis.""?","Yes, indirectly it does lend support to the claim that methylprednisolone treats plantar fasciitis. The statement mentions methylprednisolone as one of the locally injectable steroids being compared for its effectiveness in treating plantar fasciitis. This implies that methylprednisolone is being considered as a potential treatment for plantar fasciitis. However, indirect support does not equate to definitive proof of efficacy; further investigation into clinical trials, dosages, and side effects would be necessary for a more rigorous evaluation of methylprednisolone as a treatment for plantar fasciitis." +18008318,Methylprednisolone treats dermatomyositis,1254,A Japanese woman was treated with injectable methylprednisolone and oral prednisolone for dermatomyositis.,True,"'Does the phrase ""Methylprednisolone treats dermatomyositis"" receive at least indirect support from the statement: ""A Japanese woman was treated with injectable methylprednisolone and oral prednisolone for dermatomyositis.""?","Yes, the statement does provide indirect support for the claim that methylprednisolone treats dermatomyositis. The key term here is ""indirect support."" The statement indicates that a Japanese woman was treated for dermatomyositis using methylprednisolone (an injectable form) and prednisolone (an oral form). This suggests that these medications were part of her treatment regimen for dermatomyositis. However, it does not explicitly state that methylprednisolone was the sole or primary treatment responsible for improving her condition. - However, it is important to note that hydrocortisone has been studied in relation to myocardial infarction in other contexts as an anti-inflammatory agent for treating cardiac complications. Nonetheless, without additional information linking hydrocortisone to the study mentioned in the statement, we cannot infer that it is being used as a treatment for myocardial infarction in this case." -12524121,Hydrocortisone treats neoplasm,1206,"Retinoic acid treatment controls ACTH and cortisol hyperactivity and tumor size in dogs with ACTH-secreting tumors, leading to resolution of the clinical phenotype.",False,"Is the triple 'Hydrocortisone treats neoplasm' supported by the sentence: 'Retinoic acid treatment controls ACTH and cortisol hyperactivity and tumor size in dogs with ACTH-secreting tumors, leading to resolution of the clinical phenotype.'?","No, the statement does not provide direct or indirect support for the claim that ""Hydrocortisone treats neoplasm."" The study referenced in the statement investigates the effects of retinoic acid treatment on dogs suffering from ACTH-secreting tumors (a type of neoplasm), focusing on ACTH and cortisol hyperactivity as well as tumor size reduction leading to resolution of clinical symptoms. However, hydrocortisone is not mentioned in this study as a treatment option for neoplasm; therefore, it does not lend support for that specific claim. + To provide more direct support for the claim, additional information would be needed, such as details on whether her symptoms improved after receiving methylprednisolone, whether other treatments were administered concurrently, or whether there were any controlled studies demonstrating the efficacy of methylprednisolone specifically for dermatomyositis. Nonetheless, based on the information provided, it is reasonable to infer that methylprednisolone is used in the treatment of dermatomyositis in some cases." +17478785,Methylprednisolone treats nasal cavity polyp,1255,"The study by Van Zele et al reports positive results for a randomized, double-blind, placebo-controlled trial that used either 20 days of doxycycline (200 mg the first day, followed by 100 mg daily) or 20 days of a tapering schedule of methyl prednisolone (32 mg on days 1-5, 16 mg on days 6-10, and 8 mg on days 11-20) for the treatment of nasal polyps.",True,"'Does the phrase ""Methylprednisolone treats nasal cavity polyp"" receive at least indirect support from the statement: ""The study by Van Zele et al reports positive results for a randomized, double-blind, placebo-controlled trial that used either 20 days of doxycycline (200 mg the first day, followed by 100 mg daily) or 20 days of a tapering schedule of methyl prednisolone (32 mg on days 1-5, 16 mg on days 6-10, and 8 mg on days 11-20) for the treatment of nasal polyps.""?","Yes, the statement does provide indirect support for the phrase ""Methylprednisolone treats nasal cavity polyps"". The study by Van Zele et al reports positive results for a trial that used methylprednisolone as part of a tapering schedule for the treatment of nasal polyps. However, it is important to note that the study also used doxycycline as a treatment option, so it does not directly demonstrate that methylprednisolone is effective in treating nasal polyps in isolation from other treatments. Furthermore, while the study design is robust (randomized, double-blind, placebo-controlled), it is always necessary to consider the broader context of the literature when interpreting results from a single study." +15407991,Methylprednisolone treats radiculopathy,1256,"Herein, we present our experience of management of such cases with a single epidural injection of local anaesthetic, tramadol and methylprednisolone, and table tilt for management of both radiculopathies.",True,"'Does the phrase ""Methylprednisolone treats radiculopathy"" receive at least indirect support from the statement: ""Herein, we present our experience of management of such cases with a single epidural injection of local anaesthetic, tramadol and methylprednisolone, and table tilt for management of both radiculopathies.""?","Yes, the statement does provide indirect support for the phrase ""Methylprednisolone treats radiculopathy"". The statement reports the use of methylprednisolone in conjunction with local anaesthetic and tramadol for managing radiculopathies via epidural injection. This suggests that methylprednisolone was employed as part of a treatment regimen for radiculopathy cases, implying its potential therapeutic effect in treating radiculopathy. However, it is important to note that correlation does not necessarily imply causation, and further evidence would be required to definitively conclude that methylprednisolone is an effective treatment for radiculopathy." +14897628,Methylprednisolone treats neuromyelitis optica,1257,Early high-dose intravenous methylprednisolone is effective in preserving retinal nerve fiber layer thickness in patients with neuromyelitis optica.,True,"'Does the phrase ""Methylprednisolone treats neuromyelitis optica"" receive at least indirect support from the statement: ""Early high-dose intravenous methylprednisolone is effective in preserving retinal nerve fiber layer thickness in patients with neuromyelitis optica.""?","Yes, the statement does provide indirect support for the claim that methylprednisolone treats neuromyelitis optica (NMO). The statement suggests that early high-dose intravenous methylprednisolone is effective in preserving retinal nerve fiber layer thickness in patients with NMO. This implies that methylprednisolone has a positive effect on the condition of NMO patients, thus providing indirect evidence that it can be used to treat NMO. However, it is important to note that treatment efficacy is typically evaluated based on clinical outcomes such as relapse rate, disability progression, and patient quality of life, rather than just surrogate markers like retinal nerve fiber layer thickness. Therefore, while this study suggests a potential benefit of methylprednisolone in NMO treatment, more comprehensive clinical trials would be needed for definitive conclusions." +14825096,Methylprednisolone treats West syndrome,1258,The authors report their experience with intravenous methylprednisolone for the treatment of infantile spasms.,True,"'Does the phrase ""Methylprednisolone treats West syndrome"" receive at least indirect support from the statement: ""The authors report their experience with intravenous methylprednisolone for the treatment of infantile spasms.""?","Yes, indirectly it does lend support. The statement ""The authors report their experience with intravenous methylprednisolone for the treatment of infantile spasms"" suggests that methylprednisolone has been used in treating infantile spasms, which is one of the symptoms of West syndrome. However, it doesn't provide direct evidence that methylprednisolone treats West syndrome as a whole, because West syndrome is not just characterized by infantile spasms but also by developmental delay or regression and hypsarrhythmia on EEG. Therefore, more comprehensive studies would be needed to confirm that methylprednisolone treats West syndrome." +14690661,Methylprednisolone treats Meniere disease,1259,OBJECTIVE: To describe the long-term efficacy of transtympanic steroids (TTS) using methyl-prednisolone in the treatment of Meniere's disease (MD).,True,"'Does the phrase ""Methylprednisolone treats Meniere disease"" receive at least indirect support from the statement: ""OBJECTIVE: To describe the long-term efficacy of transtympanic steroids (TTS) using methyl-prednisolone in the treatment of Meniere's disease (MD).""?","Yes, the statement does provide indirect support for the phrase ""Methylprednisolone treats Meniere disease"". The objective of the study explicitly mentions using methyl-prednisolone in the treatment of Meniere's disease (MD), which suggests that methylprednisolone is being considered as a therapeutic agent for this condition. However, it is important to note that describing the long-term efficacy of a treatment does not necessarily equate to endorsement of that treatment as standard care; it simply means that an investigation into its effectiveness is being conducted. Therefore, while there is some backing for the connection between methylprednisolone and Meniere disease treatment in this statement, it is not definitive proof that methylprednisolone is an established treatment for Meniere disease." +14636779,Methylprednisolone treats neoplasm,1260,"Rats with stereotactically implanted Walker 256 tumors were treated with methylprednisolone, U-74006F, U-78517F, or vehicle (0.05 N HCl) on Days 6 through 10 following implantation.",False,"'Does the phrase ""Methylprednisolone treats neoplasm"" receive at least indirect support from the statement: ""Rats with stereotactically implanted Walker 256 tumors were treated with methylprednisolone, U-74006F, U-78517F, or vehicle (0.05 N HCl) on Days 6 through 10 following implantation.""?","No, the phrase ""Methylprednisolone treats neoplasm"" does not receive direct support from the statement provided. The statement describes an experiment where rats with Walker 256 tumors were treated with various substances including methylprednisolone. However, it does not provide information on the outcomes of these treatments, such as tumor regression or reduction in size, which would be necessary to support the claim that methylprednisolone treats neoplasm. Therefore, based on this statement alone, we cannot infer that methylprednisolone is an effective treatment for neoplasm." +14398238,Methylprednisolone treats IgA glomerulonephritis,1261,"CONCLUSIONS: Methylprednisolone and cyclophosphamide in children with Grade IV IgA nephropathy stabilized renal function and significantly reduced hematuria, proteinuria, mesangial IgA deposition, and the renal pathological activity index.",True,"'Does the phrase ""Methylprednisolone treats IgA glomerulonephritis"" receive at least indirect support from the statement: ""CONCLUSIONS: Methylprednisolone and cyclophosphamide in children with Grade IV IgA nephropathy stabilized renal function and significantly reduced hematuria, proteinuria, mesangial IgA deposition, and the renal pathological activity index.""?","Yes, the statement does provide indirect support for the claim that methylprednisolone treats IgA glomerulonephritis (IgAN), specifically in children with Grade IV IgAN. The conclusion states that treatment with methylprednisolone and cyclophosphamide in children with Grade IV IgAN resulted in stabilized renal function and significant reductions in hematuria, proteinuria, mesangial IgA deposition, and the renal pathological activity index. - While both hydrocortisone and retinoic acid can have effects on cortisol levels in the body due to their glucocorticoid properties, they should not be assumed interchangeable in treating neoplasms based on this one study alone. Further investigation is required before making any definitive conclusions about hydrocortisone's efficacy in treating neoplasms based on retinoic acid studies." -11965490,Hydrocortisone treats injury,1207,Diurnal cortisol in schizophrenia patients with childhood trauma.,False,Is the triple 'Hydrocortisone treats injury' supported by the sentence: 'Diurnal cortisol in schizophrenia patients with childhood trauma.'?,"No, the statement ""Diurnal cortisol in schizophrenia patients with childhood trauma"" does not provide indirect support for the claim that ""Hydrocortisone treats injury"". + IgA nephropathy (IgAN) is an autoimmune disease that affects the kidneys and can lead to glomerulonephritis, which is inflammation of the glomeruli (the filtering units of the kidneys). Methylprednisolone is a corticosteroid that has anti-inflammatory effects and is often used in treating autoimmune diseases. - The statement discusses diurnal cortisol levels in schizophrenia patients who have experienced childhood trauma. Cortisol is a stress hormone that follows a diurnal rhythm, meaning it has regular fluctuations throughout the day. The study might be investigating how childhood trauma affects cortisol levels in schizophrenia patients. However, it does not mention hydrocortisone or its therapeutic effects in treating injuries. Hydrocortisone is a synthetic glucocorticoid hormone often used in medicine for its anti-inflammatory properties in treating various conditions such as allergies, skin disorders, and autoimmune diseases; it is not typically used for treating injuries in general. + In this study, treating children with Grade IV IgAN (the most severe form of IgAN) with methylprednisolone resulted in improvements in several key factors related to kidney function and IgAN progression (hematuria," +14232595,Methylprednisolone treats membranous glomerulonephritis,1262,"MN was treated with methylprednisolone as first-line therapy, then she was changed to rituximab for a relapse.",True,"'Does the phrase ""Methylprednisolone treats membranous glomerulonephritis"" receive at least indirect support from the statement: ""MN was treated with methylprednisolone as first-line therapy, then she was changed to rituximab for a relapse.""?","Yes, indirectly it does support that methylprednisolone can be used in treating membranous glomerulonephritis (MN). The statement indicates that a patient (referred to as ""she"") was initially treated for MN using methylprednisolone as the first-line therapy. This suggests that methylprednisolone was effective enough in managing MN for it to be used as an initial treatment option; otherwise, it would not have been chosen as such by the treating physician(s). - In conclusion, while both statements discuss cortisol-related topics, they do not provide any indirect support for each other as they cover different areas within cortisol research." -11029944,Hydrocortisone treats eye disorder,1208,Topical compound F in the treatment of anterior segment eye disease; a preliminary report.,False,Is the triple 'Hydrocortisone treats eye disorder' supported by the sentence: 'Topical compound F in the treatment of anterior segment eye disease; a preliminary report.'?,"No, the statement ""Topical compound F in the treatment of anterior segment eye disease; a preliminary report"" does not provide direct or indirect support for the claim that ""Hydrocortisone treats eye disorder."" The statement refers specifically to topical compound F, not hydrocortisone, as a potential treatment for anterior segment eye disease. Additionally, it is only a preliminary report, indicating that further investigation is needed before any definitive conclusions can be drawn about its efficacy as a treatment option." -10518308,Hydrocortisone treats ulcerative colitis,1209,Treatment of ulcerative colitis with local hydrocortisone.,True,Is the triple 'Hydrocortisone treats ulcerative colitis' supported by the sentence: 'Treatment of ulcerative colitis with local hydrocortisone.'?,"Yes, the statement ""Treatment of ulcerative colitis with local hydrocortisone"" does provide indirect support for the claim that ""Hydrocortisone treats ulcerative colitis."" This is because it suggests that hydrocortisone has been used successfully in treating ulcerative colitis in some capacity. However, it is important to note that direct support would require more explicit evidence linking hydrocortisone as an effective treatment for ulcerative colitis in general, not only in local applications. Also, it should be considered that ulcerative colitis is a complex disease that may require personalized treatment plans due to its various manifestations in patients. Therefore, while hydrocortisone might be helpful in treating certain cases or symptoms, it might not be equally effective for all patients suffering from ulcerative colitis." -10516843,Hydrocortisone treats diffuse alopecia areata,1210,"Alopecia areata, partialis, and totalis; treatment with cortisone, hydrocortisone and their analogs, prednisone and prednisolone.",True,"Is the triple 'Hydrocortisone treats diffuse alopecia areata' supported by the sentence: 'Alopecia areata, partialis, and totalis; treatment with cortisone, hydrocortisone and their analogs, prednisone and prednisolone.'?","Yes, the phrase ""Hydrocortisone treats diffuse alopecia areata"" does receive indirect support from the statement: ""Alopecia areata, partialis, and totalis; treatment with cortisone, hydrocortisone and their analogs, prednisone and prednisolone."" + However, it is important to note that membranous glomerulonephritis can relapse even after initial treatment, as seen in this case where the patient was changed from methylprednisolone to rituximab due to relapse. This does not negate methylprednisolone's potential efficacy in treating MN but rather highlights that different patients may respond differently to various medications even when treating the same condition. - The statement provides indirect evidence that hydrocortisone can be used in treating alopecia areata because it is listed as one of the treatment options alongside other corticosteroids such as cortisone, prednisone, and prednisolone for alopecia conditions (areata, partialis, and totalis). Alopecia areata is a form of hair loss that can be diffuse (spread out evenly over the scalp) or patchy (in specific areas). Therefore, if hydrocortisone is effective in treating alopecia areata in general, it can also be applied to diffuse alopecia areata. However, it is essential to note that further investigation would be necessary for more direct support since the original statement does not explicitly mention diffuse alopecia areata in conjunction with hydroc" -10492262,Hydrocortisone treats osteoarthritis,1211,Phenylbutazone and compound F for osteoarthritis of the hip; a survey and clinical report.,False,Is the triple 'Hydrocortisone treats osteoarthritis' supported by the sentence: 'Phenylbutazone and compound F for osteoarthritis of the hip; a survey and clinical report.'?,"No, the statement ""Phenylbutazone and compound F for osteoarthritis of the hip; a survey and clinical report"" does not provide indirect support for the claim that hydrocortisone treats osteoarthritis. The statement only mentions phenylbutazone and compound F as potential treatments for osteoarthritis, but it does not mention hydrocortisone at all. Therefore, there is no basis for inferring that hydrocortisone is an effective treatment for osteoarthritis from this statement alone. + Therefore, based on the given statement, methylprednisolone does receive indirect support for treating membranous glomerulonephritis as first-line therapy; however, individual patient responses can vary significantly, necess" +14027935,Methylprednisolone treats diffuse large B-cell lymphoma,1263,"This study evaluated the influence of prior exposure to rituximab on response rates and survival in patients with diffuse large B-cell lymphoma treated with rituximab plus etoposide, cytarabine, cisplatinum and methylprednisolone (R-ESHAP).",False,"'Does the phrase ""Methylprednisolone treats diffuse large B-cell lymphoma"" receive at least indirect support from the statement: ""This study evaluated the influence of prior exposure to rituximab on response rates and survival in patients with diffuse large B-cell lymphoma treated with rituximab plus etoposide, cytarabine, cisplatinum and methylprednisolone (R-ESHAP).""?","No, the statement does not provide indirect support for the phrase ""Methylprednisolone treats diffuse large B-cell lymphoma."" The study in question examines the impact of prior exposure to rituximab on response rates and survival in patients with diffuse large B-cell lymphoma treated with a specific combination therapy that includes methylprednisolone (R-ESHAP). It does not investigate or imply that methylprednisolone alone is an effective treatment for diffuse large B-cell lymphoma. Therefore, no conclusions can be drawn about methylprednisolone's efficacy in treating diffuse large B-cell lymphoma based solely on this statement." +13679356,Methylprednisolone treats hemophagocytic syndrome,1264,"A 46 year old woman who presented with severe multiorgans involvement including liver brain, cardio-pulmonary failure, gastrointestinal bleeding, progressive cytopenia, DIC and hemophagocytic syndrome during the convalescent phase of Dengue type II has been successfully treated primarily with pulse methyl prednisolone and high dose intravenous immunoglobulin G.",True,"'Does the phrase ""Methylprednisolone treats hemophagocytic syndrome"" receive at least indirect support from the statement: ""A 46 year old woman who presented with severe multiorgans involvement including liver brain, cardio-pulmonary failure, gastrointestinal bleeding, progressive cytopenia, DIC and hemophagocytic syndrome during the convalescent phase of Dengue type II has been successfully treated primarily with pulse methyl prednisolone and high dose intravenous immunoglobulin G.""?","Yes, the phrase ""Methylprednisolone treats hemophagocytic syndrome"" does receive indirect support from the statement provided. - + The statement describes a case of a patient with hemophagocytic syndrome (HS) among other complications, who was successfully treated primarily with pulse methylprednisolone and high dose intravenous immunoglobulin G (IVIG). This suggests that methylprednisolone was an effective part of the treatment regimen for HS in this particular case. - However, it is worth noting that hydrocortisone is indeed used as an injectable treatment for osteoarthritis in some cases due to its anti-inflammatory properties. This use is supported by other studies that have specifically investigated hydrocortisone as a treatment for osteoarthritis. Nonetheless, based solely on the statement provided, there is no evidence to support the claim that hydrocortisone is an effective treatment for osteoarthritis." -10480635,Hydrocortisone treats atopic conjunctivitis,1212,"Hydrocortisone in treatment of allergic conjunctivitis, allergic rhinitis, and bronchial asthma.",True,"Is the triple 'Hydrocortisone treats atopic conjunctivitis' supported by the sentence: 'Hydrocortisone in treatment of allergic conjunctivitis, allergic rhinitis, and bronchial asthma.'?","Yes, the statement ""Hydrocortisone in treatment of allergic conjunctivitis, allergic rhinitis, and bronchial asthma"" does lend indirect support to the claim that hydrocortisone treats atopic conjunctivitis. This is because atopic conjunctivitis falls under the broader category of allergic conjunctivitis, which is explicitly mentioned in the provided statement as being treated by hydrocortisone. + However, it's important to note that this is a single case report, which means it lacks the power of larger studies to definitively establish cause-and-effect relationships. Additionally, the patient had multiple complications beyond HS, making it difficult to isolate the effect of methylprednisolone on HS specifically. Therefore, while this report provides some support for the use of methylprednisolone in treating HS, it does not conclusively prove that methylprednisolone is an effective treatment for HS in all cases. Further studies, particularly randomized controlled trials, would be needed to establish more robust evidence for the effic" +13619118,Methylprednisolone treats chronic obstructive pulmonary disease,1265,"In conclusion, methylprednisolone in combination with conventional medical therapy not only improved lung function values but also mean nocturnal oxyhemoglobin saturation and sleep duration in clinically stabilized COPD patients who experience nocturnal oxyhemoglobin desaturation.",True,"'Does the phrase ""Methylprednisolone treats chronic obstructive pulmonary disease"" receive at least indirect support from the statement: ""In conclusion, methylprednisolone in combination with conventional medical therapy not only improved lung function values but also mean nocturnal oxyhemoglobin saturation and sleep duration in clinically stabilized COPD patients who experience nocturnal oxyhemoglobin desaturation.""?","Yes, the statement does provide indirect support for the claim that methylprednisolone treats chronic obstructive pulmonary disease (COPD). The study suggests that methylprednisolone, when used in combination with conventional medical therapy, has beneficial effects on lung function values, nocturnal oxyhemoglobin saturation, and sleep duration in clinically stabilized COPD patients who experience nocturnal oxyhemoglobin desaturation. This implies that methylprednisolone may help alleviate symptoms of COPD and potentially slow disease progression. However, it is important to note that ""treats"" typically implies a causal relationship and curative effects, which may not be fully established by this statement alone. Further studies would be needed to definitively conclude that methylprednisolone treats COPD." +13533673,Methylprednisolone treats macrophage activation syndrome,1266,"Following treatment with etanercept, ibuprofen, methylprednisolone, and phenylbutazone for 3 weeks, MAS deteriorated and fatal cerebral edema occurred within only 24 h.",False,"'Does the phrase ""Methylprednisolone treats macrophage activation syndrome"" receive at least indirect support from the statement: ""Following treatment with etanercept, ibuprofen, methylprednisolone, and phenylbutazone for 3 weeks, MAS deteriorated and fatal cerebral edema occurred within only 24 h.""?","No, the statement does not provide indirect support for the phrase ""Methylprednisolone treats macrophage activation syndrome (MAS)"". In fact, it seems to suggest that methylprednisolone, along with other treatments, did not prevent deterioration of MAS in this particular case. The patient's condition worsened rapidly after 3 weeks of treatment, which included methylprednisolone, leading to fatal cerebral edema within 24 hours. This suggests that methylprednisolone was not effective in treating MAS in this instance. However, it is important to note that the ineffectiveness of methylprednisolone in this single case does not necessarily mean it is ineffective in all cases of MAS; further studies would be needed to make such a determination." +13161419,Methylprednisolone treats systemic sclerosis,1267,"CONCLUSION: The results of this pilot study suggest that the combination of MMF, IV MP and low-dose GC might achieve good clinical, functional and radiological results in patients suffering from severe early SSc.",True,"'Does the phrase ""Methylprednisolone treats systemic sclerosis"" receive at least indirect support from the statement: ""CONCLUSION: The results of this pilot study suggest that the combination of MMF, IV MP and low-dose GC might achieve good clinical, functional and radiological results in patients suffering from severe early SSc.""?","Yes, indirect support can be inferred from the statement provided. The conclusion of the pilot study indicates that a combination therapy including intravenous Methylprednisolone (IV MP) has shown promising results in treating severe early Systemic Sclerosis (SSc). However, it is important to note that Methylprednisolone is used in combination with Mycophenolate Mofetil (MMF) and low-dose Glucocorticoids (GC), not as a standalone treatment for SSc in this study. - + The study does not explicitly state that Methylprednisolone alone treats systemic sclerosis; rather it suggests that it is an effective component of a broader treatment regimen for severe early SSc patients. Nonetheless, its inclusion in a successful treatment protocol does lend indirect support to its potential therapeutic value in managing SSc symptoms. - However, it is important to note that while the statement provides some level of support for the claim, it does not constitute direct evidence. This is because atopic conjunctivitis is not specifically mentioned in the statement; therefore, further investigation would be necessary to confirm whether hydrocortisone is indeed an effective treatment for atopic conjunctivitis specifically. + Further investigation would be necessary to determine whether Methylprednisolone could be used effectively as monotherapy for treating systemic sclerosis, as well as understanding any potential side effects associated with its use in SSc treatment regimens." +13096165,Methylprednisolone treats optic nerve disorder,1268,"Dysthyroid optic neuropathy is best treated with intravenous pulsed methylprednisolone; if visual functions do not recover, urgent surgical decompression is indicated.",True,"'Does the phrase ""Methylprednisolone treats optic nerve disorder"" receive at least indirect support from the statement: ""Dysthyroid optic neuropathy is best treated with intravenous pulsed methylprednisolone; if visual functions do not recover, urgent surgical decompression is indicated.""?","Yes, the phrase ""Methylprednisolone treats optic nerve disorder"" does receive indirect support from the statement provided. - + The statement suggests that dysthyroid optic neuropathy (an optic nerve disorder) is treated with intravenous pulsed methylprednisolone. This implies that methylprednisolone is an effective treatment for this specific type of optic nerve disorder. Therefore, it can be inferred that methylprednisolone does have some therapeutic effect on certain optic nerve disorders, providing indirect support for the initial phrase. However, it is important to note that the effectiveness of methylprednisolone may vary depending on the specific type of optic nerve disorder, as suggested by the qualification ""dysthyroid"" in the provided statement." +12975348,Methylprednisolone treats mature T-cell and NK-cell non-Hodgkin lymphoma,1269,"Gemcitabine, cisplatin and methylprednisolone for the treatment of patients with peripheral T-cell lymphoma: the Royal Marsden Hospital experience.",True,"'Does the phrase ""Methylprednisolone treats mature T-cell and NK-cell non-Hodgkin lymphoma"" receive at least indirect support from the statement: ""Gemcitabine, cisplatin and methylprednisolone for the treatment of patients with peripheral T-cell lymphoma: the Royal Marsden Hospital experience.""?","Yes, indirect support can be inferred from the statement. The provided statement mentions methylprednisolone as part of a treatment regimen for peripheral T-cell lymphoma at the Royal Marsden Hospital. Peripheral T-cell lymphoma is a subtype of non-Hodgkin lymphoma. Therefore, it suggests that methylprednisolone is used in treating certain types of non-Hodgkin lymphoma. However, it does not explicitly state that methylprednisolone treats mature T-cell and NK-cell non-Hodgkin lymphoma. The statement also does not provide information about the efficacy of methylprednisolone in treating these specific subtypes. Therefore, while there is some indirect support, further evidence would be needed for a more definitive conclusion." +12450216,Methylprednisolone treats bronchopulmonary dysplasia,1270,Hypertrophic cardiomyopathy in preterm infants treated with methylprednisolone for bronchopulmonary dysplasia.,True,"'Does the phrase ""Methylprednisolone treats bronchopulmonary dysplasia"" receive at least indirect support from the statement: ""Hypertrophic cardiomyopathy in preterm infants treated with methylprednisolone for bronchopulmonary dysplasia.""?","Yes, indirect support can be inferred from the statement provided. The key term here is indirect support which means that while the statement does not explicitly state that methylprednisolone treats bronchopulmonary dysplasia (BPD), it does imply that methylprednisolone is used in the treatment of conditions associated with BPD, in this case, hypertrophic cardiomyopathy in preterm infants. - Additionally, it is crucial to consider potential differences in treatment efficacy between various conditions that fall under the umbrella term ""allergic conjunctivitis."" For instance, atopic conjunctivitis may respond differently to hydrocortisone treatment compared to other forms of allergic conjunctivitis. Therefore, while" -10280121,Hydrocortisone treats melanoma,1213,"METHOD: Adrenocorticotropic hormone (ACTH), cortisol, and interleukin-6 (IL-6) plasma concentrations were measured in 14 patients with malignant melanoma at regular intervals during the first 12 weeks of IFN-alpha therapy, both immediately before and 1, 2, and 3 hours after IFN-alpha administration.",False,"Is the triple 'Hydrocortisone treats melanoma' supported by the sentence: 'METHOD: Adrenocorticotropic hormone (ACTH), cortisol, and interleukin-6 (IL-6) plasma concentrations were measured in 14 patients with malignant melanoma at regular intervals during the first 12 weeks of IFN-alpha therapy, both immediately before and 1, 2, and 3 hours after IFN-alpha administration.'?","No, the statement does not provide indirect support for the claim that hydrocortisone treats melanoma. The method described in the statement is measuring various plasma concentrations in melanoma patients undergoing IFN-alpha therapy, without any mention of hydrocortisone administration or its effects on melanoma treatment. Hydrocortisone is not even indirectly implied in any part of the process being described in the methodology provided." -10221382,Hydrocortisone treats atopic eczema,1214,"These data show clobetasone butyrate 0.05% is more effective than 1.0% hydrocortisone in the treatment of eczema and more effective than flurandrenolone 0.0125% (p=0.01%) and a potent topical steroid hydrocortisone butyrate (p<0.05), in the treatment of psoriasis.",False,"Is the triple 'Hydrocortisone treats atopic eczema' supported by the sentence: 'These data show clobetasone butyrate 0.05% is more effective than 1.0% hydrocortisone in the treatment of eczema and more effective than flurandrenolone 0.0125% (p=0.01%) and a potent topical steroid hydrocortisone butyrate (p<0.05), in the treatment of psoriasis.'?","No, the statement does not provide indirect support for the claim that hydrocortisone treats atopic eczema. The statement indeed mentions that 1% hydrocortisone is less effective than clobetasone butyrate 0.05% in treating psoriasis specifically. However, it does not provide any information about hydrocortisone's effectiveness in treating atopic eczema. Therefore, we cannot infer from this statement that hydrocortisone is an effective treatment for atopic eczema." -9971730,Hydrocortisone treats pneumonia,1215,The use of extracorporeal immunopharmacotherapy with diucifon in 53 patients and the retrosternal injection of isoniazid in combination with hydrocortisone in 43 patients have shown their efficiencies in the treatment of patients with caseous pneumonia.,False,Is the triple 'Hydrocortisone treats pneumonia' supported by the sentence: 'The use of extracorporeal immunopharmacotherapy with diucifon in 53 patients and the retrosternal injection of isoniazid in combination with hydrocortisone in 43 patients have shown their efficiencies in the treatment of patients with caseous pneumonia.'?,"No, the phrase ""Hydrocortisone treats pneumonia"" does not receive direct support from the statement provided. The statement mentions that hydrocortisone was used in combination with isoniazid for treating caseous pneumonia in 43 patients, but it does not specify that hydrocortisone alone was responsible for treating pneumonia in those patients. Therefore, we cannot infer that hydrocortisone is an effective treatment for pneumonia based solely on this information. + Bronchopulmonary dysplasia is a chronic lung disease that primarily affects preterm infants. It is characterized by inflammation and scarring in the lungs. The fact that methylprednisolone is used in treating hypertrophic cardiomyopathy in preterm infants who have BPD suggests that methylprednisolone may have some therapeutic effect on BPD or its complications. - However, it is important to note that hydrocortisone is sometimes used as an adjunct treatment in severe cases of pneumonia due to its anti-inflammatory effects (Cabral et al., 2015). This means that while hydrocortisone may not be sufficient on its own to treat pneumonia, it could potentially play a role in managing severe symptoms when used in combination with other treatments. Nonetheless, more rigorous studies would be needed to establish hydrocortisone as an evidence-based treatment for pneumonia. + However, it is important to note that this does not constitute direct evidence of methylprednisolone's effectiveness in treating BPD itself. It could be that methylprednisolone is used to treat complications of BPD or other conditions that co-occur with BPD in" +11895116,Methylprednisolone treats plasma cell myeloma,1271,Multiple myeloma of Stage IIa was diagnosed and she was given cytostatic therapy with 17.5 mg melphalan and 112 mg methylprednisolone daily by mouth (for 4 days at intervals of 6 weeks).,True,"'Does the phrase ""Methylprednisolone treats plasma cell myeloma"" receive at least indirect support from the statement: ""Multiple myeloma of Stage IIa was diagnosed and she was given cytostatic therapy with 17.5 mg melphalan and 112 mg methylprednisolone daily by mouth (for 4 days at intervals of 6 weeks).""?","Yes, the statement does provide indirect support for the claim that methylprednisolone treats plasma cell myeloma. The statement indicates that a patient diagnosed with multiple myeloma of Stage IIa was given cytostatic therapy that included methylprednisolone as part of their treatment regimen. The use of methylprednisolone in this context suggests that it may have some therapeutic effect on multiple myeloma, which is a type of plasma cell myeloma. However, it is essential to note that methylprednisolone was used in combination with melphalan, which may also contribute to the treatment efficacy. Therefore, while there is some support for the claim, it is not based on methylprednisolone being used as a standalone treatment for plasma cell myeloma in this particular case." +11882768,Methylprednisolone treats Cognitive impairment,1272,One-year cyclophosphamide treatment combined with methylprednisolone improves cognitive dysfunction in progressive forms of multiple sclerosis.,True,"'Does the phrase ""Methylprednisolone treats Cognitive impairment"" receive at least indirect support from the statement: ""One-year cyclophosphamide treatment combined with methylprednisolone improves cognitive dysfunction in progressive forms of multiple sclerosis.""?","Yes, indirectly it does provide some support for the statement that methylprednisolone treats cognitive impairment. The provided statement suggests that methylprednisolone, when used in combination with cyclophosphamide, can improve cognitive dysfunction in progressive forms of multiple sclerosis (MS). This implies that methylprednisolone has some therapeutic effect on cognitive impairment in MS patients. However, it's important to note that this doesn't necessarily mean that methylprednisolone alone can treat cognitive impairment in all contexts, as the study focuses on a specific patient population and treatment regimen. The effectiveness of methylprednisolone in treating cognitive impairment outside of this context would need further investigation." +11547088,Methylprednisolone treats thrombotic thrombocytopenic purpura,1273,"The hematologic evaluations and her clinical course revealed the diagnosis of TTP, so plasma exchange and methyl-prednisolone therapy were initiated.",True,"'Does the phrase ""Methylprednisolone treats thrombotic thrombocytopenic purpura"" receive at least indirect support from the statement: ""The hematologic evaluations and her clinical course revealed the diagnosis of TTP, so plasma exchange and methyl-prednisolone therapy were initiated.""?","Yes, the phrase ""Methylprednisolone treats thrombotic thrombocytopenic purpura (TTP)"" does receive indirect support from the statement provided. - References: - Cabral, R. M., de Oliveira, R. F., da Silva, D" -9665107,Hydrocortisone treats prostate cancer,1216,"Therefore, a prospective phase II study was conducted to assess the efficacy and safety of a regimen of low dose (200 mg.) oral ketoconazole 3 times daily with replacement doses of hydrocortisone in men with androgen independent prostate cancer.",False,"Is the triple 'Hydrocortisone treats prostate cancer' supported by the sentence: 'Therefore, a prospective phase II study was conducted to assess the efficacy and safety of a regimen of low dose (200 mg.) oral ketoconazole 3 times daily with replacement doses of hydrocortisone in men with androgen independent prostate cancer.'?","No, the statement does not provide direct or indirect support for the claim that hydrocortisone treats prostate cancer. The study mentioned in the statement investigates the efficacy and safety of ketoconazole in combination with replacement doses of hydrocortisone for men with androgen-independent prostate cancer. The use of hydrocortisone in this case is primarily for replacement therapy due to ketoconazole-induced adrenal suppression rather than as a treatment for prostate cancer itself. Therefore, it does not imply that hydrocortisone alone can be used as a treatment for prostate cancer." -9535781,Hydrocortisone treats adrenocortical insufficiency,1217,"Long term hydrocortisone therapy for his adrenal insufficiency may have prevented a faster course of the liver disease, whereas the heterozygous alpha1-antitrypsin deficiency and moderate alcohol consumption constituted additional risk factors ultimately leading to the development of cirrhosis.",True,"Is the triple 'Hydrocortisone treats adrenocortical insufficiency' supported by the sentence: 'Long term hydrocortisone therapy for his adrenal insufficiency may have prevented a faster course of the liver disease, whereas the heterozygous alpha1-antitrypsin deficiency and moderate alcohol consumption constituted additional risk factors ultimately leading to the development of cirrhosis.'?","Yes, the statement does provide indirect support for the claim that hydrocortisone treats adrenocortical insufficiency. The key phrase here is ""long term hydrocortisone therapy for his adrenal insufficiency."" This implies that hydrocortisone was used as a treatment for adrenocortical insufficiency. + The statement indicates that a patient was diagnosed with TTP and was treated with plasma exchange and methylprednisolone therapy. This suggests that methylprednisolone was used as part of the treatment regimen for TTP in this specific case. However, it is important to note that correlation does not imply causation; therefore, we cannot definitively conclude that methylprednisolone was solely responsible for treating TTP in this instance. - However, it's important to note that while the statement suggests hydrocortisone therapy may have slowed down liver disease progression, it does not explicitly state that hydrocortisone treats adrenocortical insufficiency in the sense of curing it. Instead, it seems to be managing it effectively enough to prevent faster progression of liver disease in conjunction with other risk factors. + Nonetheless, it is well-established in medical literature that plasma exchange is the first-line treatment for TTP (Zheng XL, Zhang Y, Chen HJ, et al., 2014). Methylprednisolone is also commonly used as an adjunctive therapy in TTP treatment due to its potential immunomodulatory effects (Szczepiorkowski ZM, Skoner DP, Chaturvedi P, et al., 2006). Therefore, based on the information" +11313619,Methylprednisolone treats vestibular neuronitis,1274,"METHODS: We performed a prospective, randomized, double-blind, two-by-two factorial trial in which patients with acute vestibular neuritis were randomly assigned to treatment with placebo, methylprednisolone, valacyclovir, or methylprednisolone plus valacyclovir.",True,"'Does the phrase ""Methylprednisolone treats vestibular neuronitis"" receive at least indirect support from the statement: ""METHODS: We performed a prospective, randomized, double-blind, two-by-two factorial trial in which patients with acute vestibular neuritis were randomly assigned to treatment with placebo, methylprednisolone, valacyclovir, or methylprednisolone plus valacyclovir.""?","Yes, the statement does provide indirect support for the claim that methylprednisolone treats vestibular neuronitis. The methods section of the study describes a randomized controlled trial where patients with acute vestibular neuritis were treated with methylprednisolone. This design is consistent with established standards for determining efficacy of treatments in clinical trials. However, it is important to note that indirect support does not equate to definitive proof of efficacy. The actual results and conclusions of the study would need to be evaluated to determine if methylprednisolone has a statistically significant positive effect on vestibular neuronitis." +10801960,Methylprednisolone treats B-cell chronic lymphocytic leukemia,1275,High dose methylprednisolone can induce remissions in CLL patients with p53 abnormalities.,True,"'Does the phrase ""Methylprednisolone treats B-cell chronic lymphocytic leukemia"" receive at least indirect support from the statement: ""High dose methylprednisolone can induce remissions in CLL patients with p53 abnormalities.""?","Yes, indirect support can be inferred from the statement provided. The claim ""High dose methylprednisolone can induce remissions in CLL patients with p53 abnormalities"" suggests that methylprednisolone has therapeutic effects on B-cell chronic lymphocytic leukemia (CLL) patients, specifically those with p53 abnormalities. However, it does not explicitly state that methylprednisolone treats all cases of B-cell chronic lymphocytic leukemia, regardless of p53 status. Therefore, while not direct support, it does provide some level of indirect support for the initial claim. - Therefore, while there is support for hydrocortisone as a treatment for adrenocortical insufficiency in terms of symptom management or slowing disease progression, it does not necessarily mean that hydrocortisone can cure adrenocortical insufficiency." -9459897,Hydrocortisone treats hypotensive disorder,1218,"After 24-h age, a subgroup (n = 8) received up to four doses (0.5-1.0 mg/kg each) of hydrocortisone for refractory hypotension.",True,"Is the triple 'Hydrocortisone treats hypotensive disorder' supported by the sentence: 'After 24-h age, a subgroup (n = 8) received up to four doses (0.5-1.0 mg/kg each) of hydrocortisone for refractory hypotension.'?","Yes, the statement does provide indirect support for the phrase ""Hydrocortisone treats hypotensive disorder"". The reason is that it mentions hydrocortisone being administered specifically to treat refractory hypotension in a subgroup of subjects. While not a direct causal relationship, it does suggest that hydrocortisone was used as a treatment for low blood pressure (hypotension) in this context. However, it is important to note that this is an observational finding in a specific subset of subjects, and further rigorous studies would be needed to establish hydrocortisone as an evidence-based treatment for hypotensive disorder in general." -9175521,Hydrocortisone treats type 1 diabetes mellitus,1219,"Interaction of endogenous growth hormone, cortisol, and catecholamines with blood glucose in children with brittle diabetes mellitus.",False,"Is the triple 'Hydrocortisone treats type 1 diabetes mellitus' supported by the sentence: 'Interaction of endogenous growth hormone, cortisol, and catecholamines with blood glucose in children with brittle diabetes mellitus.'?","No, the phrase ""Hydrocortisone treats type 1 diabetes mellitus"" does not receive at least indirect support from the statement: ""Interaction of endogenous growth hormone, cortisol, and catecholamines with blood glucose in children with brittle diabetes mellitus."" + That being said, it is important to note that the statement only refers to CLL patients with p53 abnormalities, not all CLL patients. This nuance should be taken into account when interpreting the evidence provided. Furthermore, while methylprednisolone may induce remissions in these specific patients, it does not necessarily mean it is a primary treatment for B-cell chronic lymphocytic leukemia. Other factors such as side effects, long-term efficacy" +10634179,Methylprednisolone treats Crohn disease,1276,An example of acute pancreatitis developing five weeks after initial treatment with 5-aminosalicylic acid (5-ASA) and methylprednisolone for severe Crohn's disease is reported in a 37 year old female patient.,False,"'Does the phrase ""Methylprednisolone treats Crohn disease"" receive at least indirect support from the statement: ""An example of acute pancreatitis developing five weeks after initial treatment with 5-aminosalicylic acid (5-ASA) and methylprednisolone for severe Crohn's disease is reported in a 37 year old female patient.""?","No, the statement does not provide direct or indirect support for the claim that ""Methylprednisolone treats Crohn disease."" The statement describes an adverse event (acute pancreatitis) that occurred five weeks after initial treatment of Crohn's disease with both 5-aminosalicylic acid (5-ASA) and methylprednisolone in a single patient case report. It does not provide any information about the therapeutic effect of methylprednisolone on Crohn disease. - The reason for my decision is that although cortisol is mentioned in the statement, it does not imply that hydrocortisone specifically is used as a treatment for type 1 diabetes mellitus. Cortisol is a naturally occurring hormone in the human body, while hydrocortisone is a synthetic form of cortisol often used as a medication in various medical contexts. + The misconception here might be due to assuming that any report of a treatment for Crohn disease is inherently positive, when in fact, adverse events can also be reported in such cases. It is crucial to differentiate between therapeutic effects and adverse events when interpreting medical literature." +10341065,Methylprednisolone treats severe acute respiratory syndrome,1277,Twenty-nine of the 30 SARS patients were treated by methylprednisolone.,True,"'Does the phrase ""Methylprednisolone treats severe acute respiratory syndrome"" receive at least indirect support from the statement: ""Twenty-nine of the 30 SARS patients were treated by methylprednisolone.""?","Yes, the statement ""Twenty-nine of the 30 SARS patients were treated by methylprednisolone"" does provide indirect support for the claim that ""Methylprednisolone treats severe acute respiratory syndrome (SARS)"". The high proportion of SARS patients receiving methylprednisolone treatment suggests that there may be some therapeutic benefit associated with its use in treating SARS symptoms. - Furthermore, the statement refers only to ""children with brittle diabetes mellitus,"" which is often used interchangeably with type 1 diabetes mellitus but can also indicate poorly controlled type 1 or type 2 diabetes mellitus. The interaction between cortisol and blood glucose in these children does not provide sufficient evidence that hydrocortisone is used as a treatment for type 1 diabetes mellitus in general." -8776300,Hydrocortisone treats Inflammation,1220,"Acidification with a topical solution of 2 percent acetic acid combined with hydrocortisone for inflammation is effective treatment in most cases and, when used after exposure to moisture, is an excellent prophylactic.",True,"Is the triple 'Hydrocortisone treats Inflammation' supported by the sentence: 'Acidification with a topical solution of 2 percent acetic acid combined with hydrocortisone for inflammation is effective treatment in most cases and, when used after exposure to moisture, is an excellent prophylactic.'?","Yes, the statement does provide indirect support for the phrase ""Hydrocortisone treats Inflammation"". The reason is that hydrocortisone is mentioned in conjunction with treating inflammation in the provided context. However, it is essential to note that hydrocortisone is not being described as treating inflammation independently but rather as part of a topical solution that includes acidification with 2 percent acetic acid. + However, it is important to note that correlation does not imply causation. The fact that most SARS patients were given methylprednisolone does not necessarily mean that methylprednisolone is solely responsible for improving their condition. Other factors such as additional treatments, patient characteristics, and disease progression may also have contributed to patient recovery. - The statement suggests that hydrocortisone is an effective treatment for inflammation when used in combination with acidification in most cases and can also act as a preventative measure after exposure to moisture. This implies that hydrocortisone has anti-inflammatory properties but may require additional substances (acetic acid) for optimal efficacy in certain situations. + To establish more direct support for the claim that methylprednisolone treats SARS, additional evidence such as controlled clinical trials comparing methylprednisolone-treated patients against placebo-treated patients would be required. These studies would allow researchers to determine whether any observed improvements in SARS patients could be attributed specifically to methylprednisolone treatment while accounting for potential conf" +10289517,Methylprednisolone treats graft versus host disease,1278,"CASE SUMMARY: A 2-year-old white boy with a history of relapsed acute lymphoblastic leukemia underwent a bone marrow transplant and developed graft-versus-host disease, which was treated with methylprednisolone.",True,"'Does the phrase ""Methylprednisolone treats graft versus host disease"" receive at least indirect support from the statement: ""CASE SUMMARY: A 2-year-old white boy with a history of relapsed acute lymphoblastic leukemia underwent a bone marrow transplant and developed graft-versus-host disease, which was treated with methylprednisolone.""?","Yes, the statement does provide indirect support for the claim that methylprednisolone treats graft versus host disease. The case summary describes a patient who developed graft-versus-host disease after a bone marrow transplant and was treated with methylprednisolone. This suggests that methylprednisolone was used as an intervention for graft-versus-host disease, implying that it is an accepted treatment for this condition. However, it's important to note that this is an indirect inference based on observational evidence from a single case. For a more robust validation of the claim, controlled clinical trials would be required." +10221573,Methylprednisolone treats myeloproliferative neoplasm,1279,The effects of HDMP should be explored in patients with other subtypes of AML who present with MT.,False,"'Does the phrase ""Methylprednisolone treats myeloproliferative neoplasm"" receive at least indirect support from the statement: ""The effects of HDMP should be explored in patients with other subtypes of AML who present with MT.""?","No, the phrase ""Methylprednisolone treats myeloproliferative neoplasm"" does not receive indirect support from the statement: ""The effects of HDMP should be explored in patients with other subtypes of AML who present with MT."" - Nonetheless, it is important not to overstate the strength of evidence provided by this single statement alone without considering other relevant literature on hydrocortisone's therapeutic effects on inflammation." -8632826,Hydrocortisone treats bronchopulmonary dysplasia,1221,"To study a possible relation between the use of postnatal glucocorticoids and the incidence and severity of retinopathy of prematurity (ROP), we conducted a retrospective study over a 4-year period that compared data of 161 preterm infants treated with hydrocortisone for bronchopulmonary dysplasia (BPD) with the data of 253 controls.",False,"Is the triple 'Hydrocortisone treats bronchopulmonary dysplasia' supported by the sentence: 'To study a possible relation between the use of postnatal glucocorticoids and the incidence and severity of retinopathy of prematurity (ROP), we conducted a retrospective study over a 4-year period that compared data of 161 preterm infants treated with hydrocortisone for bronchopulmonary dysplasia (BPD) with the data of 253 controls.'?","No, the statement does not provide direct support for the claim that ""Hydrocortisone treats bronchopulmonary dysplasia"". The study mentioned is investigating the relationship between postnatal glucocorticoids (which include hydrocortisone) and retinopathy of prematurity (ROP) in preterm infants who were treated for bronchopulmonary dysplasia (BPD). While it indicates that hydrocortisone was used in treating infants with BPD, it does not provide evidence that hydrocortisone itself is responsible for treating BPD. The purpose of the study is focused on ROP incidence and severity in these infants rather than on hydrocortisone's therapeutic effect on BPD itself." -8540090,"Hydrocortisone treats dermatitis, atopic",1222,Topical treatment with urea-hydrocortisone in atopic dermatitis.,True,"Is the triple 'Hydrocortisone treats dermatitis, atopic' supported by the sentence: 'Topical treatment with urea-hydrocortisone in atopic dermatitis.'?","Yes, the statement ""Topical treatment with urea-hydrocortisone in atopic dermatitis"" does lend indirect support to the phrase ""Hydrocortisone treats dermatitis, atopic."" The reason is that hydrocortisone is one of the active components in the topical treatment mentioned in the statement. + + The statement refers to High-Dose Methylprednisolone (HDMP) and its potential effects on patients with other subtypes of Acute Myeloid Leukemia (AML) presenting with Measurable Residual Disease (MRD). Myeloproliferative Neoplasm (MPN) is a distinct category of hematological malignancies that includes conditions such as Polycythemia Vera, Essential Thrombocythemia, and Myelofibrosis. - Hydrocortisone is a type of corticosteroid that is commonly used in treating various forms of dermatitis, including atopic dermatitis (eczema). The statement indicates that hydrocortisone is used in combination with urea for treating atopic dermatitis patients with topical treatment. + + Although both AML and MPN fall under the broader umbrella of hematological malignancies, they represent different disease entities with distinct pathophysiological mechanisms. Therefore, evidence supporting the exploration of HDMP in AML patients does not provide indirect support for the use of Methylprednisolone in treating MPNs. - While it does not explicitly prove that hydrocortisone alone can treat atopic dermatitis in all cases, it does support the idea that hydrocortisone is an active ingredient in treating atopic dermatitis when used topically in combination therapies. + + It" +10136260,Methylprednisolone treats acute lymphoblastic leukemia,1280,"We examined the effect of high-dose methylprednisolone (HDMP) on blast reduction rate and compared it to conventional dose steroid treatment, administered during the first 7+ days of the induction remission period in patients with acute lymphoblastic leukemia (ALL).",True,"'Does the phrase ""Methylprednisolone treats acute lymphoblastic leukemia"" receive at least indirect support from the statement: ""We examined the effect of high-dose methylprednisolone (HDMP) on blast reduction rate and compared it to conventional dose steroid treatment, administered during the first 7+ days of the induction remission period in patients with acute lymphoblastic leukemia (ALL).""?","Yes, indirect support can be inferred from the statement provided. The study examined the effect of high-dose methylprednisolone (HDMP) on blast reduction rate in patients with acute lymphoblastic leukemia (ALL), comparing it to conventional dose steroid treatment during the induction remission period. The use of methylprednisolone specifically for treating ALL is not explicitly stated; however, conducting such a study implies that there is some rationale for investigating its potential therapeutic benefits in ALL treatment. This rationale could stem from previous evidence suggesting its efficacy or potential mechanisms of action that could be beneficial in treating ALL. Therefore, while not direct evidence, it does provide some level of indirect support for the claim that methylprednisolone could be used in treating ALL." +10049014,"Methylprednisolone treats dermatitis, atopic",1281,"The objective of this multicentre, parallel, blinded, randomized controlled study was to evaluate the efficacy and the safety of cyclosporine (CsA group, 117 dogs) in comparison with methylprednisolone (MP group, 59 dogs) in the treatment of atopic dermatitis for 4 months.",True,"'Does the phrase ""Methylprednisolone treats dermatitis, atopic"" receive at least indirect support from the statement: ""The objective of this multicentre, parallel, blinded, randomized controlled study was to evaluate the efficacy and the safety of cyclosporine (CsA group, 117 dogs) in comparison with methylprednisolone (MP group, 59 dogs) in the treatment of atopic dermatitis for 4 months.""?","Yes, the statement does provide indirect support for the phrase ""Methylprednisolone treats dermatitis, atopic"". The study mentioned is designed to compare the efficacy and safety of cyclosporine and methylprednisolone in treating atopic dermatitis in dogs over four months. The fact that methylprednisolone is used in a treatment group suggests that it has been considered as a potential treatment for atopic dermatitis. However, it is important to note that indirect support does not equate to definitive proof of efficacy. The study would need to present results showing that methylprednisolone is effective in treating atopic dermatitis in order for there to be direct support for the claim." +9980473,Methylprednisolone treats immunoglobulin a vasculitis,1282,"CASE DESCRIPTION: A 33-year-old woman previously treated with methylprednisolone and cyclophosphamide for Henoch-Schonlein purpura was transferred from a referring hospital because of sore throat, fever, and chills.",False,"'Does the phrase ""Methylprednisolone treats immunoglobulin a vasculitis"" receive at least indirect support from the statement: ""CASE DESCRIPTION: A 33-year-old woman previously treated with methylprednisolone and cyclophosphamide for Henoch-Schonlein purpura was transferred from a referring hospital because of sore throat, fever, and chills.""?","No, the statement does not provide direct or indirect support for the claim that ""Methylprednisolone treats immunoglobulin A vasculitis."" The case description mentions that a patient was treated with methylprednisolone for Henoch-Schonlein purpura (HSP), which is not the same as immunoglobulin A (IgA) vasculitis. Although HSP is often considered a form of IgA vasculitis, there is ongoing debate in the medical community regarding their equivalence. Therefore, it cannot be concluded that methylprednisolone is an effective treatment for IgA vasculitis based solely on this statement." +9720542,Methylprednisolone treats lupus nephritis,1283,The last significant breakthrough in the treatment of systemic lupus erythematosus (SLE) was the use of cyclophosphamide and methylprednisolone in the treatment of lupus nephritis.,True,"'Does the phrase ""Methylprednisolone treats lupus nephritis"" receive at least indirect support from the statement: ""The last significant breakthrough in the treatment of systemic lupus erythematosus (SLE) was the use of cyclophosphamide and methylprednisolone in the treatment of lupus nephritis.""?","Yes, the statement does provide indirect support for the phrase ""Methylprednisolone treats lupus nephritis."" The key term here is 'indirect.' The statement suggests that cyclophosphamide and methylprednisolone have been used in treating lupus nephritis, which is a severe complication of systemic lupus erythematosus (SLE). This implies that methylprednisolone has some therapeutic effect on lupus nephritis, even though it does not explicitly state that methylprednisolone treats lupus nephritis on its own. However, it is important to note that the statement does not provide direct evidence of methylprednisolone's efficacy in treating lupus nephritis in isolation from cyclophosphamide. Therefore, further investigation would be necessary to establish methylprednisolone as an independent treatment for lupus nephritis." +8761529,Methylprednisolone treats asthma,1284,Methylprednisolone suleptanate (Promedrol) is a prodrug of methylprednisolone being developed by Pharmacia Corp (formerly Pharmacia & Upjohn) for the treatment of asthma.,True,"'Does the phrase ""Methylprednisolone treats asthma"" receive at least indirect support from the statement: ""Methylprednisolone suleptanate (Promedrol) is a prodrug of methylprednisolone being developed by Pharmacia Corp (formerly Pharmacia & Upjohn) for the treatment of asthma.""?","Yes, there is indirect support for the claim that ""Methylprednisolone treats asthma"" based on the provided statement. This support comes from understanding that Methylprednisolone suleptanate (Promedrol) is a prodrug of methylprednisolone being developed for asthma treatment by Pharmacia Corp (formerly Pharmacia & Upjohn). - However, it is essential to consider that each patient may respond differently to treatments, and various factors such as dosage, frequency, severity, and duration of treatment can influence outcomes. It is also important" -8412499,Hydrocortisone treats obesity disorder,1223,"We studied the interactions of leptin, insulin and cortisol in obese children and adolescents at different stages of maturation.",False,"Is the triple 'Hydrocortisone treats obesity disorder' supported by the sentence: 'We studied the interactions of leptin, insulin and cortisol in obese children and adolescents at different stages of maturation.'?","No, the statement does not provide direct or indirect support for the claim that hydrocortisone treats obesity disorder. The study mentioned investigates the interactions between leptin, insulin, and cortisol in obese children and adolescents at various stages of maturation. Although cortisol is mentioned in the study, it does not imply that hydrocortisone (a synthetic form of cortisol) is used as a treatment for obesity disorder. The statement only suggests that cortisol levels were observed in relation to obesity in children and adolescents." -8248241,Hydrocortisone treats Sepsis,1224,[Cortisol in critically ill patients with sepsis: physiologic functions and therapeutic implications].,True,Is the triple 'Hydrocortisone treats Sepsis' supported by the sentence: '[Cortisol in critically ill patients with sepsis: physiologic functions and therapeutic implications].'?,"Yes, there is indirect support for the statement ""Hydrocortisone treats sepsis"" from the provided reference ""[Cortisol in critically ill patients with sepsis: physiologic functions and therapeutic implications]."" Hydrocortisone is a synthetic glucocorticoid that can be used to supplement cortisol levels in humans. In sepsis patients, cortisol levels can be insufficient due to dysregulation in the hypothalamic-pituitary-adrenal (HPA) axis, contributing to hemodynamic instability and immune dysfunction (Annane et al., 2002). + A prodrug is an inactive or less active form of a drug that is metabolically converted into its active form in the body after administration (Stella, 2013). In this case, Methylprednisolone suleptanate (Promedrol) is a prodrug of methylprednisolone, meaning that once it enters the body, it will be metabolized into methylprednisolone. - By supplementing cortisol levels with hydrocortisone in sepsis patients, one can potentially restore immune homeostasis and improve clinical outcomes (Annane et al., 2002). However, it is important to note that not all sepsis patients will benefit from hydrocortisone therapy, as it is mainly recommended for patients who demonstrate signs of adrenal insufficiency (Sprung et al., 2008). + Methylprednisolone is a type of corticosteroid that is commonly used in treating asthma due to its potent anti-inflammatory effects (Barnes & Adcock, 2003). By reducing inflammation in the airways, methylprednisolone helps" +8588816,Methylprednisolone treats Bell's palsy,1285,"On these basis, we have studied the efficacity of parenteral association of 30 mg/Kg/j of Aciclovir and 1 mg/Kg/j of Methylprednisolone in the treatment of Bell's palsy with less than 12 days of evolution.",True,"'Does the phrase ""Methylprednisolone treats Bell's palsy"" receive at least indirect support from the statement: ""On these basis, we have studied the efficacity of parenteral association of 30 mg/Kg/j of Aciclovir and 1 mg/Kg/j of Methylprednisolone in the treatment of Bell's palsy with less than 12 days of evolution.""?","Yes, the statement does provide indirect support for the claim that Methylprednisolone treats Bell's palsy. The study mentioned in the statement is investigating the efficacy of both Aciclovir and Methylprednisolone in treating Bell's palsy that has been present for less than 12 days. The inclusion of Methylprednisolone in this treatment regimen suggests that it has some therapeutic benefit in treating Bell's palsy, thus providing indirect support for the claim. However, it is important to note that this is an indirect inference and further direct evidence would be needed to definitively support the claim that Methylprednisolone alone treats Bell's palsy." +8568939,Methylprednisolone treats myasthenia gravis,1286,"Treatment with methylprednisolone for myasthenia gravis was associated with a marked decrease in both biochemical markers of bone formation and resorption without any changes in endogenous cAMP and serum levels of calcium, PTH, and 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3].",False,"'Does the phrase ""Methylprednisolone treats myasthenia gravis"" receive at least indirect support from the statement: ""Treatment with methylprednisolone for myasthenia gravis was associated with a marked decrease in both biochemical markers of bone formation and resorption without any changes in endogenous cAMP and serum levels of calcium, PTH, and 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3].""?","No, the statement does not provide indirect support for the phrase ""Methylprednisolone treats myasthenia gravis."" The statement discusses the effects of methylprednisolone treatment on myasthenia gravis in terms of bone formation and resorption markers, endogenous cAMP, serum levels of calcium, PTH, and 1,25-(OH)2D3. Although it suggests that methylprednisolone has an effect on myasthenia gravis patients, it does not provide evidence that it alleviates symptoms of myasthenia gravis, which is what would be required for indirect support of the phrase ""Methylprednisolone treats myasthenia gravis."" - In summary, while the statement does not" -8061437,Hydrocortisone treats congenital adrenal hyperplasia,1225,"We conclude that the regimen of flutamide, testolactone, reduced hydrocortisone dose, and fludrocortisone provides effective control of congenital adrenal hyperplasia with reduced risk of glucocorticoid excess.",True,"Is the triple 'Hydrocortisone treats congenital adrenal hyperplasia' supported by the sentence: 'We conclude that the regimen of flutamide, testolactone, reduced hydrocortisone dose, and fludrocortisone provides effective control of congenital adrenal hyperplasia with reduced risk of glucocorticoid excess.'?","Yes, indirectly it does support that statement because hydrocortisone is mentioned as part of an effective regimen for treating congenital adrenal hyperplasia (CAH). The original statement suggests that reduced hydrocortisone dosage in combination with flutamide, testolactone, and fludrocortisone provides effective control of CAH while minimizing risks associated with glucocorticoid excess. Since hydrocortisone is one component in this suggested treatment plan, it implies that hydrocortisone plays a role in treating CAH effectively. However, it does not explicitly state that hydrocortisone treats CAH alone; rather it emphasizes its use as part of an overall treatment strategy that also includes other medications like flutamide, testolactone, and fludrocortisone." -8054429,Hydrocortisone treats borderline personality disorder,1226,RESULTS: The cortisol and prolactin responses to the m-CPP challenge in BPD patients were significantly lower compared to those in controls.,False,Is the triple 'Hydrocortisone treats borderline personality disorder' supported by the sentence: 'RESULTS: The cortisol and prolactin responses to the m-CPP challenge in BPD patients were significantly lower compared to those in controls.'?,"No, the statement does not provide indirect support for the claim that hydrocortisone treats borderline personality disorder (BPD). The results presented in the statement indicate altered cortisol responses in BPD patients when challenged with m-CPP (m-Chlorophenylpiperazine), which is a serotonin agonist used in neuroendocrine studies. However, these findings do not establish any link between hydrocortisone treatment and BPD symptoms improvement. Hydrocortisone is a synthetic glucocorticoid that can influence various physiological processes related to stress response; however, based on this information alone, no conclusions can be drawn about its therapeutic potential for BPD. Additional studies specifically investigating hydrocortisone as an intervention for BPD would be required to provide support for such a claim." -7996696,Hydrocortisone treats toxic shock syndrome,1227,Two recent small randomized trials evaluating a 5- to 12-day course of low dose hydrocortisone in patients with septic shock have reported a significant clinical improvement and a reduction in mortality.,True,Is the triple 'Hydrocortisone treats toxic shock syndrome' supported by the sentence: 'Two recent small randomized trials evaluating a 5- to 12-day course of low dose hydrocortisone in patients with septic shock have reported a significant clinical improvement and a reduction in mortality.'?,"Yes, indirectly it does lend some support. The statement mentions that low dose hydrocortisone in patients with septic shock led to significant clinical improvement and reduced mortality. Toxic shock syndrome is a severe form of sepsis caused by bacterial toxins; therefore, it shares many characteristics with septic shock. This suggests that hydrocortisone might potentially have similar positive effects on toxic shock syndrome patients due to its impact on sepsis in general. However, it is important to note that toxic shock syndrome is distinct from septic shock in terms of causative agents and pathophysiology; thus, direct clinical extrapolation should be made cautiously and preferably based on further clinical trials specifically targeting toxic shock syndrome patients." -7882717,Hydrocortisone treats castration-resistant prostate carcinoma,1228,"We have studied intravenous docetaxel 70 mg/m2, oral estramustine, and low-dose daily hydrocortisone in men with HRPC who demonstrated progression after initial hormone therapy.",True,"Is the triple 'Hydrocortisone treats castration-resistant prostate carcinoma' supported by the sentence: 'We have studied intravenous docetaxel 70 mg/m2, oral estramustine, and low-dose daily hydrocortisone in men with HRPC who demonstrated progression after initial hormone therapy.'?","Yes, indirectly it does. The statement mentions that low-dose daily hydrocortisone was used in a study involving men with castration-resistant prostate carcinoma (HRPC) who had progressed after initial hormone therapy. However, it does not provide information on the outcomes or efficacy of hydrocortisone in treating HRPC. Therefore, while there is some support for the claim based on the context provided, more direct evidence would be needed to fully substantiate it. + To provide indirect support for that phrase, one would need evidence suggesting that methylprednisolone is associated with improvements in myasthenia gravis symptoms or overall patient well-being. While it is possible that changes in bone formation and resorption markers could be related to improvements in symptoms, the statement does not explicitly make that connection. Therefore, it is not possible to infer that methylprednisolone is an effective treatment for my" +8562694,Methylprednisolone treats endocrine exophthalmos,1287,PATIENTS AND METHODS: Fourteen euthyroid patients with severe Graves' ophthalmopathy were treated with high-dose intravenous methylprednisolone during 6 months and followed-up for 24-48 months by clinical and ophthalmological assessment.,True,"'Does the phrase ""Methylprednisolone treats endocrine exophthalmos"" receive at least indirect support from the statement: ""PATIENTS AND METHODS: Fourteen euthyroid patients with severe Graves' ophthalmopathy were treated with high-dose intravenous methylprednisolone during 6 months and followed-up for 24-48 months by clinical and ophthalmological assessment.""?","Yes, the statement does provide indirect support for the claim that methylprednisolone treats endocrine exophthalmos (a symptom of Graves' ophthalmopathy). The reason is that the patients in question were treated with high-dose intravenous methylprednisolone over six months, followed by clinical and ophthalmological assessment for 24-48 months. If methylprednisolone had no effect on endocrine exophthalmos, it is unlikely that physicians would continue its use for such an extended period. However, it is important to note that while this study suggests a potential positive effect of methylprednisolone on Graves' ophthalmopathy symptoms like exophthalmos, it does not definitively prove that methylprednisolone is a treatment for endocrine exophthalmos as it does not report on specific outcomes related to exophthalmos nor control for other potential factors influencing outcomes in these patients. Further studies with more specific outcome measures related to exophthalmos would be needed for stronger support of this claim." +8503951,Methylprednisolone treats ulcerative colitis,1288,The current study evaluated the efficacy and safety of unfractionated heparin in the treatment of ulcerative colitis in comparison with methylprednisolone.,True,"'Does the phrase ""Methylprednisolone treats ulcerative colitis"" receive at least indirect support from the statement: ""The current study evaluated the efficacy and safety of unfractionated heparin in the treatment of ulcerative colitis in comparison with methylprednisolone.""?","Yes, the statement does provide indirect support for the claim that ""Methylprednisolone treats ulcerative colitis"". The study mentioned is comparing unfractionated heparin with methylprednisolone in treating ulcerative colitis. The fact that methylprednisolone is included in such a study suggests that it is being considered as a potential treatment for ulcerative colitis. However, it is important to note that indirect support does not equate to definitive proof of efficacy. The actual results of the study would need to be evaluated in order to make any conclusions about methylprednisolone's effectiveness in treating ulcerative colitis. Additionally, it should be noted that correlation does not imply causation; even if methylprednisolone was used in conjunction with improved patient outcomes in the study, it does not necessarily mean that methylprednisolone was the cause of those improvements." +8464737,Methylprednisolone treats kidney disorder,1289,"Post partum acute renal failure and type IV lupus nephropathy were treated with hemodialysis, methylprednisolone, cyclophosphamide and prednisone.",True,"'Does the phrase ""Methylprednisolone treats kidney disorder"" receive at least indirect support from the statement: ""Post partum acute renal failure and type IV lupus nephropathy were treated with hemodialysis, methylprednisolone, cyclophosphamide and prednisone.""?","Yes, the statement does provide indirect support for the claim that methylprednisolone treats kidney disorder. The statement indicates that methylprednisolone was used in combination with other treatments for post partum acute renal failure and type IV lupus nephropathy, both of which involve kidney dysfunction. Therefore, it can be inferred that methylprednisolone was employed as part of a treatment regimen for these kidney disorders. However, it is important to note that methylprednisolone was used in conjunction with other treatments, so it does not necessarily prove that methylprednisolone alone is effective in treating kidney disorders. Additionally, further evidence from clinical trials would be required for definitive proof of its efficacy in treating kidney disorders as monotherapy or as part of combination therapy." +8427466,Methylprednisolone treats sinusitis,1290,"To resolve the controversy over whether corticosteroids promote or inhibit the resolution of sinusitis, we present a prospective study of 80 rabbits with surgically introduced pseudomonal sinusitis that were then treated in one of four arms: control, ceftazidime, methylprednisolone, and ceftazidime with methylprednisolone.",True,"'Does the phrase ""Methylprednisolone treats sinusitis"" receive at least indirect support from the statement: ""To resolve the controversy over whether corticosteroids promote or inhibit the resolution of sinusitis, we present a prospective study of 80 rabbits with surgically introduced pseudomonal sinusitis that were then treated in one of four arms: control, ceftazidime, methylprednisolone, and ceftazidime with methylprednisolone.""?","Yes, indirectly. The statement does provide some level of support for the claim that methylprednisolone can treat sinusitis because it describes a prospective study where rabbits with pseudomonal sinusitis were treated with methylprednisolone as one of the treatment arms. However, it is important to note that direct support for the claim would require specific results showing that methylprednisolone treatment led to significant improvements in sinusitis symptoms or resolution compared to other treatment arms or control group. Therefore, further information about the outcomes of this study would be necessary for stronger support of the claim." +8330903,Methylprednisolone treats systemic lupus erythematosus,1291,MAIN RESULTS: We found no randomised controlled trials comparing cyclophosphamide versus methylprednisolone for the treatment of neuropsychiatric involvement in the systemic lupus erythematosus.,False,"'Does the phrase ""Methylprednisolone treats systemic lupus erythematosus"" receive at least indirect support from the statement: ""MAIN RESULTS: We found no randomised controlled trials comparing cyclophosphamide versus methylprednisolone for the treatment of neuropsychiatric involvement in the systemic lupus erythematosus.""?","No, the statement does not provide indirect support for the claim that ""Methylprednisolone treats systemic lupus erythematosus."" The statement is from a study abstract that mentions no randomized controlled trials comparing cyclophosphamide versus methylprednisolone for neuropsychiatric involvement in systemic lupus erythematosus (SLE). The lack of such trials does not imply that methylprednisolone is an effective treatment for SLE; it only highlights gaps in existing research regarding neuropsychiatric involvement specifically. - The use of hydrocortisone in prostate cancer treatment is often associated with palliative care rather than as a primary treatment for castration-resistant prostate carcinoma. Hydrocortisone can help manage symptoms such as pain and inflammation in patients receiving other treatments like chemotherapy (docetaxel). Nonetheless, further investigation into clinical trials, studies, or meta-analyses focused on hydrocortisone's specific effects on HRPC would be required for stronger support." -7698304,Hydrocortisone treats otitis externa,1229,"Results of clinical trials indicate that ofloxacin otic solution 0.3% is as effective as topical neomycin/polymixin B/hydrocortisone preparations in the treatment of otitis externa (clinical cure rate >80% in adults and >95% in children for both treatments) and oral amoxicillin/clavulanic acid in the treatment of otitis media in the presence of tympanostomy tubes in children (clinical cure rates 76 and 69% for ofloxacin and amoxicillin/clavulanic acid, respectively).",False,"Is the triple 'Hydrocortisone treats otitis externa' supported by the sentence: 'Results of clinical trials indicate that ofloxacin otic solution 0.3% is as effective as topical neomycin/polymixin B/hydrocortisone preparations in the treatment of otitis externa (clinical cure rate >80% in adults and >95% in children for both treatments) and oral amoxicillin/clavulanic acid in the treatment of otitis media in the presence of tympanostomy tubes in children (clinical cure rates 76 and 69% for ofloxacin and amoxicillin/clavulanic acid, respectively).'?","No, the statement does not provide direct support for the claim that hydrocortisone treats otitis externa. However, it does offer indirect evidence suggesting that hydrocortisone may be an effective component in treating otitis externa when used in combination with other agents such as neomycin/polymixin B (topical preparations). The statement highlights comparable clinical cure rates for both treatments in adults and children, implying that hydrocortisone is an active ingredient contributing to the efficacy observed in these trials. However, it does not explicitly confirm that hydrocortisone alone is responsible for treating otitis externa, nor does it specify its exact therapeutic contribution in such treatments. + To further elaborate on why there is no indirect support for methylprednisolone as an SLE treatment from this statement, consider the following points: - + 1) The statement does not provide information about any trials comparing methylprednisolone against placebo or other treatments for systemic lupus erythematosus; - The distinction between indirect support and direct evidence is crucial here; while there is some indication that hydrocortisone might play a positive role in managing otitis externa based on these results, further investigation would be required before making definitive conclusions about its standalone efficacy in treating that condition specifically." -7584436,Hydrocortisone treats Crohn disease,1230,CONCLUSIONS: The observed increase in albumin binding might limit the bioactivity of cortisol in patients with Crohn's disease and contribute to the decreased effectiveness and weaker side effects of glucocorticoid therapy in these patients.,False,Is the triple 'Hydrocortisone treats Crohn disease' supported by the sentence: 'CONCLUSIONS: The observed increase in albumin binding might limit the bioactivity of cortisol in patients with Crohn's disease and contribute to the decreased effectiveness and weaker side effects of glucocorticoid therapy in these patients.'?,"No, the statement does not provide direct or indirect support for the phrase ""Hydrocortisone treats Crohn disease."" The conclusion in question discusses potential factors contributing to decreased effectiveness and weaker side effects of glucocorticoid therapy in Crohn disease patients due to increased albumin binding of cortisol. Hydrocortisone is indeed a glucocorticoid; however, reduced effectiveness does not imply that hydrocortisone cannot treat Crohn disease but rather that it might not be as effective as desired under certain conditions in some patients. The statement provides more context about possible resistance mechanisms in Crohn disease patients rather than supporting hydrocortisone as a treatment for Crohn disease." -7432481,Hydrocortisone treats pancreatitis,1231,"The amount of N-acetyl D-glucosamine in the zymogen granule membrane was not altered by caerulein acute pancreatitis induced under continuous hydrocortisone treatment, but it was decreased by the administration of L-364,718 over 7 days after pancreatitis induction.",False,"Is the triple 'Hydrocortisone treats pancreatitis' supported by the sentence: 'The amount of N-acetyl D-glucosamine in the zymogen granule membrane was not altered by caerulein acute pancreatitis induced under continuous hydrocortisone treatment, but it was decreased by the administration of L-364,718 over 7 days after pancreatitis induction.'?","No, the statement does not provide indirect support for the claim that hydrocortisone treats pancreatitis. The statement discusses the effect of hydrocortisone on N-acetyl D-glucosamine levels in zymogen granule membranes in relation to pancreatitis induced by caerulein. However, it does not provide any information about hydrocortisone's potential therapeutic effect on pancreatitis. In fact, it does not mention pancreatitis treatment at all. Therefore, it does not offer any indirect support for the claim that hydrocortisone treats pancreatitis." -7402054,Hydrocortisone treats fibromyalgia,1232,Graded ACTH infusion revealed similar increases in cortisol in women with fibromyalgia and healthy controls.,False,Is the triple 'Hydrocortisone treats fibromyalgia' supported by the sentence: 'Graded ACTH infusion revealed similar increases in cortisol in women with fibromyalgia and healthy controls.'?,"No, the statement does not provide indirect support for the claim that hydrocortisone treats fibromyalgia. The statement only suggests that there is no significant difference in cortisol response between women with fibromyalgia and healthy controls when given graded ACTH infusion. Hydrocortisone is a synthetic form of cortisol; however, this statement does not provide any information about hydrocortisone treatment in fibromyalgia patients. Therefore, it does not support or refute the claim that hydrocortisone is an effective treatment for fibromyalgia." -7378370,Hydrocortisone treats chronic primary adrenal insufficiency,1233,The effects of endogenous opioids and cortisol on thyrotropin and prolactin secretion in patients with Addison's disease.,False,Is the triple 'Hydrocortisone treats chronic primary adrenal insufficiency' supported by the sentence: 'The effects of endogenous opioids and cortisol on thyrotropin and prolactin secretion in patients with Addison's disease.'?,"No, the statement does not provide direct or indirect support for the claim that hydrocortisone treats chronic primary adrenal insufficiency (often referred to as Addison's disease). The statement focuses on endogenous opioids and cortisol's effects on thyrotropin and prolactin secretion in patients with Addison's disease. However, it does not mention hydrocortisone or its therapeutic application in treating chronic primary adrenal insufficiency. + 2) The focus of the study is on neuropsychiatric involvement in SLE, which may not represent systemic SLE as a whole; - + 3) The statement does not report any positive outcomes for methylprednisolone in treating SLE;" +8291810,Methylprednisolone treats pneumonia,1292,High-dose methylprednisolone was administered for treatment of the pneumonitis.,True,"'Does the phrase ""Methylprednisolone treats pneumonia"" receive at least indirect support from the statement: ""High-dose methylprednisolone was administered for treatment of the pneumonitis.""?","Yes, there is indirect support for the statement ""Methylprednisolone treats pneumonia"" from ""High-dose methylprednisolone was administered for treatment of the pneumonitis."" - Hydrocortisone is indeed a common treatment for Addison's disease as it replaces the missing cortisol hormone in these patients. Nonetheless, the provided statement does not offer any information that could be used to substantiate that link. It is essential to base conclusions on evidence that directly addresses the claim in question." -7363431,Hydrocortisone treats asthma,1234,[Dynamics of the cortisol content in the blood plasma in specific hyposensibilization in children with bronchial asthma].,False,Is the triple 'Hydrocortisone treats asthma' supported by the sentence: '[Dynamics of the cortisol content in the blood plasma in specific hyposensibilization in children with bronchial asthma].'?,"No, the statement ""Hydrocortisone treats asthma"" does not receive direct or indirect support from the provided reference because the reference discusses cortisol dynamics in children with bronchial asthma during hyposensibilization but does not mention hydrocortisone treatment for asthma specifically. + The term ""pneumonitis"" refers to inflammation of lung tissue which can be caused by various factors including infections like pneumonia (Lee et al., 2015). Methylprednisolone is a type of corticosteroid often used as an anti-inflammatory agent (Barnes, 2016). Therefore, when methylprednisolone is administered in high doses for treating pneumonitis, it suggests that methylprednisolone has been used to reduce inflammation associated with pneumonia-like conditions in this case. - The title of the study is ""Dynamics of the cortisol content in the blood plasma in specific hyposensibilization in children with bronchial asthma."" Cortisol is a naturally occurring hormone in the human body that is released during stressful situations as part of the body's fight-or-flight response. Hydrocortisone is a synthetic form of cortisol that is used as a medication for various conditions such as inflammation, allergies, and autoimmune disorders. + However, it is important to note that while methylprednisolone may help manage inflammation in pneumonia patients, it does not necessarily imply that it treats pneumonia itself as pneumonia is primarily caused by bacterial, viral, or fungal infections (Metersky et al., 2019). Antib" +8227578,Methylprednisolone treats mucocutaneous lymph node syndrome,1293,"Additional antiinflammatory therapy, such as IV methylprednisolone and IV cyclophosphamide, may be helpful in treating persistent KD.",True,"'Does the phrase ""Methylprednisolone treats mucocutaneous lymph node syndrome"" receive at least indirect support from the statement: ""Additional antiinflammatory therapy, such as IV methylprednisolone and IV cyclophosphamide, may be helpful in treating persistent KD.""?","Yes, indirect support can be inferred from the statement provided. Mucocutaneous lymph node syndrome is another name for Kawasaki Disease (KD), as mentioned in the user's statement. The statement suggests that intravenous (IV) methylprednisolone can be helpful in treating persistent KD (Kawasaki Disease). Therefore, it indirectly supports the claim that methylprednisolone treats mucocutaneous lymph node syndrome (KD) since they refer to the same medical condition. However, it is important to note that while methylprednisolone may be beneficial in treating KD, it is typically used as an additional therapy rather than a primary treatment, as indicated in the statement." +8095661,Methylprednisolone treats carpal tunnel syndrome,1294,Injection with methylprednisolone for carpal tunnel syndrome.,True,"'Does the phrase ""Methylprednisolone treats carpal tunnel syndrome"" receive at least indirect support from the statement: ""Injection with methylprednisolone for carpal tunnel syndrome.""?","Yes, the phrase ""Methylprednisolone treats carpal tunnel syndrome"" does receive indirect support from the statement: ""Injection with methylprednisolone for carpal tunnel syndrome."" - While it is true that hydrocortisone is closely related to cortisol, it is not explicitly stated in the reference that hydrocortisone is used as a treatment for asthma in children undergoing hyposensibilization therapy. Therefore, it is not possible to draw any conclusions regarding hydrocortisone as an asthma treatment" -27127545,Methylprednisolone treats lymphoproliferative syndrome,1235,Treatment of X-linked lymphoproliferative disease (Duncan disease) with high-dose methylprednisolone and etoposide (VP-16).,True,Is the triple 'Methylprednisolone treats lymphoproliferative syndrome' supported by the sentence: 'Treatment of X-linked lymphoproliferative disease (Duncan disease) with high-dose methylprednisolone and etoposide (VP-16).'?,"Yes, indirectly it does lend support. The statement indicates that high-dose methylprednisolone is used in treating X-linked lymphoproliferative disease (Duncan disease), which is a type of lymphoproliferative syndrome. Therefore, it can be inferred that methylprednisolone could potentially be used for treating other forms of lymphoproliferative syndrome as well. However, it is important to note that such an inference would need further investigation for confirmation as different subtypes of lymphoproliferative syndrome might require different treatment approaches based on their underlying causes and severities." -26450412,Methylprednisolone treats leukemia,1236,"Circadian optimization of the treatment of L1210 leukemia with 1-beta-D-arabinofuranosylcytosine, cyclophosphamide, vincristine and methylprednisolone.",True,"Is the triple 'Methylprednisolone treats leukemia' supported by the sentence: 'Circadian optimization of the treatment of L1210 leukemia with 1-beta-D-arabinofuranosylcytosine, cyclophosphamide, vincristine and methylprednisolone.'?","Yes, while the statement does not explicitly claim that methylprednisolone treats leukemia on its own, it does suggest that methylprednisolone is used in combination with other treatments for L1210 leukemia. This implies that methylprednisolone might have some therapeutic effect in treating leukemia, even if it is not the sole agent responsible for treatment success. However, it is important to note that further investigation would be needed to establish the specific effects and mechanisms of methylprednisolone in treating leukemia." -26339812,Methylprednisolone treats alcoholic hepatitis,1237,Controlled trial of methylprednisolone therapy in severe acute alcoholic hepatitis.,True,Is the triple 'Methylprednisolone treats alcoholic hepatitis' supported by the sentence: 'Controlled trial of methylprednisolone therapy in severe acute alcoholic hepatitis.'?,"Yes, the statement ""Controlled trial of methylprednisolone therapy in severe acute alcoholic hepatitis"" does provide indirect support for the claim that methylprednisolone treats alcoholic hepatitis. The use of a controlled trial implies that there is an experimental group receiving methylprednisolone therapy specifically for severe acute alcoholic hepatitis. If there is a significant improvement in the experimental group compared to the control group, it would suggest that methylprednisolone has some therapeutic effect on alcoholic hepatitis. However, it is important to note that indirect support does not equate to definitive proof. The results of the trial would need to be thoroughly evaluated in terms of study design, sample size, statistical significance, effect size, and potential confounding factors before making any definitive conclusions about the efficacy of methylprednisolone for treating alcoholic hepatitis." -26307075,Methylprednisolone treats psoriatic arthritis,1238,"1 The present study was undertaken to characterize the spectrum of arachidonic acid metabolites present in synovial effusions of patients with rheumatoid or psoriatic arthritis, and to compare changes in their concentration following a short-term treatment with 6alpha-methyl-prednisolone (6-MeP: 4-8 mg/day) or indoprofen (1.2 g/day), a nonsteroidal anti-inflammatory agent with proven synovial prostaglandin inhibitory effect.2 Measurements of prostaglandin E(2) (PGE(2)), thromboxane (TX) B(2), 6-keto-PGF(1alpha) and PGF(2alpha) were performed by radioimmunoassay techniques in synovial effusions obtained from 23 patients, and validated by thin-layer chromatographic analysis of the extracted immunoreactivity.3 PGE(2) and TXB(2) accounted for more than 60% of the total immunoreactivity in untreated patients.",False,"Is the triple 'Methylprednisolone treats psoriatic arthritis' supported by the sentence: '1 The present study was undertaken to characterize the spectrum of arachidonic acid metabolites present in synovial effusions of patients with rheumatoid or psoriatic arthritis, and to compare changes in their concentration following a short-term treatment with 6alpha-methyl-prednisolone (6-MeP: 4-8 mg/day) or indoprofen (1.2 g/day), a nonsteroidal anti-inflammatory agent with proven synovial prostaglandin inhibitory effect.2 Measurements of prostaglandin E(2) (PGE(2)), thromboxane (TX) B(2), 6-keto-PGF(1alpha) and PGF(2alpha) were performed by radioimmunoassay techniques in synovial effusions obtained from 23 patients, and validated by thin-layer chromatographic analysis of the extracted immunoreactivity.3 PGE(2) and TXB(2) accounted for more than 60% of the total immunoreactivity in untreated patients.'?","No, the statement does not provide direct support for the claim that methylprednisolone treats psoriatic arthritis. The study mentioned primarily focuses on characterizing arachidonic acid metabolites in synovial effusions in patients with rheumatoid arthritis or psoriatic arthritis before and after treatment with methylprednisolone (6-MeP) or indoprofen. The statement does not include information about the effects of methylprednisol" -26279366,Methylprednisolone treats angioimmunoblastic T-cell lymphoma,1239,Pulse methylprednisolone therapy in angioimmunoblastic lymphadenopathy.,True,Is the triple 'Methylprednisolone treats angioimmunoblastic T-cell lymphoma' supported by the sentence: 'Pulse methylprednisolone therapy in angioimmunoblastic lymphadenopathy.'?,"Yes, based on the information provided in the statement ""Pulse methylprednisolone therapy in angioimmunoblastic lymphadenopathy,"" there is indirect support for the claim that methylprednisolone treats angioimmunoblastic T-cell lymphoma (AITL). The term ""lymphadenopathy"" refers to the enlargement of lymph nodes, which is one of the symptoms associated with AITL. Additionally, ""pulse therapy"" implies that methylprednisolone is being used as a treatment for lymphadenopathy in this context. + The statement ""Injection with methylprednisolone for carpal tunnel syndrome"" implies that methylprednisolone is being used as a treatment for carpal tunnel syndrome. This is because treatments typically involve introducing substances (like methylprednisolone) into the body in order to manage or alleviate symptoms of diseases (like carpal tunnel syndrome). Therefore, if methylprednisolone is being injected into patients with carpal tunnel syndrome, it suggests that it has some therapeutic effect on the condition. - However, it is essential to note that AITL is a specific type of T-cell lymphoma, meaning that methylprednisolone may not be an effective treatment for all cases or stages of AITL. Additionally, it is unclear whether methylprednisolone is being used as a standalone treatment in this case or in conjunction with other therapies. Therefore, while there is some support for the claim based on the provided statement, further investigation is necessary to fully understand methylprednisolone's therapeutic potential in A" -25738014,Methylprednisolone treats ankylosing spondylitis,1240,Seven patients with active AS and insufficient efficacy of NSAID for three months were treated with one gram methylprednisolone daily given intravenously for three successive days.,True,Is the triple 'Methylprednisolone treats ankylosing spondylitis' supported by the sentence: 'Seven patients with active AS and insufficient efficacy of NSAID for three months were treated with one gram methylprednisolone daily given intravenously for three successive days.'?,"Yes, the statement does provide indirect support for the claim that methylprednisolone treats ankylosing spondylitis (AS). The statement describes seven patients with active AS who were treated with methylprednisolone daily for three successive days due to insufficient efficacy of NSAID for three months. The fact that methylprednisolone was used as a treatment suggests that it has some therapeutic effect on AS, thus providing indirect evidence for its use in treating AS. However, it is important to note that indirect support does not equate to definitive proof, and further studies would be required to establish methylprednisolone as an effective treatment for AS." -25734987,Methylprednisolone treats non-Hodgkin lymphoma,1241,"Peptichemio, a new oncolytic drug with alkylating and antimetabolic properties was employed in combination with vincristine and 6-methylprednisolone (PVP) for the treatment of diffuse non-Hodgkin's lymphomas (NHL), stages III and IV.",False,"Is the triple 'Methylprednisolone treats non-Hodgkin lymphoma' supported by the sentence: 'Peptichemio, a new oncolytic drug with alkylating and antimetabolic properties was employed in combination with vincristine and 6-methylprednisolone (PVP) for the treatment of diffuse non-Hodgkin's lymphomas (NHL), stages III and IV.'?","No, the statement does not provide direct support for the claim that methylprednisolone treats non-Hodgkin lymphoma. However, it does offer indirect evidence suggesting that methylprednisolone has been used in combination therapy for treating diffuse non-Hodgkin lymphomas (NHL) stages III and IV. + However, it is important to note that indirect support does not equate to definitive proof. The statement does not explicitly state that methylprednisolone treats carpal tunnel syndrome; rather it implies that methylprednisolone may have some beneficial effect on carpal tunnel syndrome symptoms when administered via injection. Further investigation would be required to establish whether methylprednisolone is an effective treatment for carpal tunnel syndrome specifically." +8083160,Methylprednisolone treats thrombocytopenia,1295,"After a course of high-dose methylprednisolone therapy with a diagnosis of Evans syndrome, complete response for thrombocytopenia and partial response for anemia was achieved.",True,"'Does the phrase ""Methylprednisolone treats thrombocytopenia"" receive at least indirect support from the statement: ""After a course of high-dose methylprednisolone therapy with a diagnosis of Evans syndrome, complete response for thrombocytopenia and partial response for anemia was achieved.""?","Yes, the statement does provide indirect support for the claim that methylprednisolone treats thrombocytopenia (low platelet count). The user statement mentions that a patient diagnosed with Evans syndrome (a condition characterized by thrombocytopenia and autoimmune hemolytic anemia) received high-dose methylprednisolone therapy and achieved a complete response for thrombocytopenia. This suggests that methylprednisolone therapy had a positive impact on treating thrombocytopenia in this case. However, it is essential to acknowledge that correlation does not imply causation; therefore, additional studies would be required for more definitive evidence of methylprednisolone as an effective treatment for thrombocytopenia in general." +8063034,Methylprednisolone treats granulomatosis with polyangiitis,1296,We describe a 44-year-old man with Wegener's granulomatosis who was treated with cyclophosphamide and methylprednisolone and who subsequently developed bilateral CMVR.,True,"'Does the phrase ""Methylprednisolone treats granulomatosis with polyangiitis"" receive at least indirect support from the statement: ""We describe a 44-year-old man with Wegener's granulomatosis who was treated with cyclophosphamide and methylprednisolone and who subsequently developed bilateral CMVR.""?","Yes, indirect support can be inferred from the statement ""We describe a 44-year-old man with Wegener’s granulomatosis who was treated with cyclophosphamide and methylprednisolone and who subsequently developed bilateral CMVR."" - + Wegener’s granulomatosis is one form of granulomatosis with polyangiitis (GPA), so the patient in question does indeed have GPA. The statement indicates that methylprednisolone was used in combination with cyclophosphamide as part of the treatment regimen for the patient’s GPA. - The key point here is that methylprednisolone is mentioned as part of a combination therapy (PVP) that includes vincristine and Peptichemio for treating NHL stages III and IV. This does not necessarily imply that methylprednisolone is solely responsible for treating NHL nor does it confirm that methylprednisolone has any specific therapeutic effect on NHL when used alone. + Although it does not explicitly demonstrate that methylprednisolone alone treats GPA, it does provide some evidence that methylprednisolone is used in treating GPA patients as part of an overall treatment plan that includes cyclophosphamide. This is consistent with existing medical literature that supports using corticosteroids like methylprednisolone in combination with other immunosuppressive drugs for treating GPA patients (Jennette et al., 2013). - + Jennette JC, Falk RJ," +8018847,Methylprednisolone treats Pain,1297,A comparative trial of botulinum toxin type A and methylprednisolone for the treatment of myofascial pain syndrome and pain from chronic muscle spasm.,True,"'Does the phrase ""Methylprednisolone treats Pain"" receive at least indirect support from the statement: ""A comparative trial of botulinum toxin type A and methylprednisolone for the treatment of myofascial pain syndrome and pain from chronic muscle spasm.""?","Yes, the statement does provide indirect support for the claim that methylprednisolone treats pain. The study referenced in the statement is comparing two treatments for myofascial pain syndrome and pain from chronic muscle spasm, one of which is methylprednisolone. The fact that it is included in such a study suggests that it has some therapeutic potential for pain relief, even if it is not as effective as the other treatment option in this particular context. However, it is important to note that methylprednisolone may not be effective for all types of pain, and its use should be based on a thorough understanding of its potential benefits and risks in specific clinical situations." +7905007,Methylprednisolone treats chronic progressive multiple sclerosis,1298,OBJECTIVE: To determine if there are variables linked to responsiveness to pulse cyclophosphamide/methylprednisolone therapy in progressive Multiple Sclerosis (MS).,False,"'Does the phrase ""Methylprednisolone treats chronic progressive multiple sclerosis"" receive at least indirect support from the statement: ""OBJECTIVE: To determine if there are variables linked to responsiveness to pulse cyclophosphamide/methylprednisolone therapy in progressive Multiple Sclerosis (MS).""?","No, the statement does not provide direct or indirect support for the claim that ""Methylprednisolone treats chronic progressive multiple sclerosis"". The objective of the study only mentions using pulse cyclophosphamide/methylprednisolone therapy in progressive Multiple Sclerosis (MS), but it does not specify which component of the therapy is responsible for any potential positive effects nor does it claim that methylprednisolone treats MS on its own. The statement is focused on determining if there are variables linked to responsiveness to the combined therapy, not on testing the efficacy of methylprednisolone specifically as a treatment for chronic progressive MS." +7853881,Methylprednisolone treats rheumatoid arthritis,1299,Oral low-dose glucocorticosteroids as compared with intravenous methylprednisolone pulses in the treatment of rheumatoid arthritis.,False,"'Does the phrase ""Methylprednisolone treats rheumatoid arthritis"" receive at least indirect support from the statement: ""Oral low-dose glucocorticosteroids as compared with intravenous methylprednisolone pulses in the treatment of rheumatoid arthritis.""?","No, the statement does not provide indirect support for the phrase ""Methylprednisolone treats rheumatoid arthritis."" The study referenced in the statement compares oral low-dose glucocorticosteroids (a class of drugs that includes methylprednisolone) with intravenous methylprednisolone pulses in treating rheumatoid arthritis. To provide indirect support for ""Methylprednisolone treats rheumatoid arthritis,"" we would need evidence specifically linking methylprednisolone treatment to improvements in rheumatoid arthritis symptoms or disease progression. - It is important to note that many chemotherapeutic drugs are often used in combination regimens because they can target different pathways involved in cancer development and progression. In such cases, attributing therapeutic effects solely to one drug within the combination can be misleading. + To clarify, while both forms of glucocorticosteroids may be effective in treating rheumatoid arthritis based on existing knowledge in the field, this specific study does not provide evidence for methylprednisolone as an effective treatment option on its own compared to other glucocorticosteroids or control groups." +7827490,Methylprednisolone treats optic neuritis,1300,CONCLUSIONS: The ONTT has led to a dramatic reduction in the use of oral prednisone without a preceding course of intravenous methylprednisolone in the treatment of acute optic neuritis.,True,"'Does the phrase ""Methylprednisolone treats optic neuritis"" receive at least indirect support from the statement: ""CONCLUSIONS: The ONTT has led to a dramatic reduction in the use of oral prednisone without a preceding course of intravenous methylprednisolone in the treatment of acute optic neuritis.""?","Yes, the statement does provide indirect support for the claim that methylprednisolone treats optic neuritis. The ONTT (Optic Neuritis Treatment Trial) led to a reduction in the use of oral prednisone without a preceding course of intravenous methylprednisolone in treating acute optic neuritis. This implies that intravenous methylprednisolone is considered more effective than oral prednisone alone in treating optic neuritis, thus supporting the use of methylprednisolone in treating this condition. However, it is important to note that direct causation cannot be inferred from an observational study such as the ONTT; therefore, further research would be necessary to definitively establish that methylprednisolone treats optic neuritis." +7808987,Methylprednisolone treats autoimmune thrombocytopenic purpura,1301,CONCLUSION: A short intravenous course of high-dose methylprednisolone is effective as initial treatment of adults with ITP.,True,"'Does the phrase ""Methylprednisolone treats autoimmune thrombocytopenic purpura"" receive at least indirect support from the statement: ""CONCLUSION: A short intravenous course of high-dose methylprednisolone is effective as initial treatment of adults with ITP.""?","Yes, the statement does provide indirect support for the phrase ""Methylprednisolone treats autoimmune thrombocytopenic purpura"" (ITP). The conclusion of the study suggests that high-dose methylprednisolone is effective in treating ITP in adults, implying that methylprednisolone has therapeutic benefits for ITP patients. Since autoimmune thrombocytopenic purpura is characterized by low platelet counts due to an immune system malfunction, it can be inferred that methylprednisolone may help manage ITP symptoms by modulating immune system activity. However, it is essential to note that further investigation is required to establish a direct cause-and-effect relationship between methylprednisolone use and ITP symptom improvement." +7700869,Methylprednisolone treats Edema,1302,"Lipid peroxidation and oedema in experimental brain injury: comparison of treatment with methylprednisolone, tirilazad mesylate and vitamin E.",True,"'Does the phrase ""Methylprednisolone treats Edema"" receive at least indirect support from the statement: ""Lipid peroxidation and oedema in experimental brain injury: comparison of treatment with methylprednisolone, tirilazad mesylate and vitamin E.""?","Yes, indirectly. The statement ""Lipid peroxidation and oedema in experimental brain injury: comparison of treatment with methylprednisolone, tirilazad mesylate and vitamin E"" does provide some level of support for the claim that methylprednisolone treats edema. This is because it mentions methylprednisolone as one of the treatments compared for edema in experimental brain injury. However, it doesn't explicitly state that methylprednisolone treats edema, hence the indirect support. To confirm this claim more directly, further evidence from clinical trials or studies that specifically test methylprednisolone as a treatment for edema would be required." +7668594,Methylprednisolone treats multiple sclerosis,1303,The same determinations were repeated on plasma and on CSF samples that were collected after the MS patients had ended a six-day treatment with high-dose methylprednisolone (MP).,True,"'Does the phrase ""Methylprednisolone treats multiple sclerosis"" receive at least indirect support from the statement: ""The same determinations were repeated on plasma and on CSF samples that were collected after the MS patients had ended a six-day treatment with high-dose methylprednisolone (MP).""?","Yes, the statement does provide indirect support for the claim that Methylprednisolone treats multiple sclerosis (MS). The key phrase in the statement that allows for this inference is ""after the MS patients had ended a six-day treatment with high-dose methylprednisolone (MP)."" - + The fact that MS patients had undergone treatment specifically with methylprednisolone suggests that this medication has some therapeutic application in treating MS. Methylprednisolone is a corticosteroid that is commonly used as an anti-inflammatory and immunosuppressive drug in various treatments including MS exacerbations [1]. - In conclusion, while it is possible that methylprednisolone" -25642231,Methylprednisolone treats heart disorder,1242,High-dose MP may be contraindicated in patients with known heart disease.,True,Is the triple 'Methylprednisolone treats heart disorder' supported by the sentence: 'High-dose MP may be contraindicated in patients with known heart disease.'?,"Yes, indirectly it does support the claim that Methylprednisolone (MP) may have an impact on heart disorders. The statement ""High-dose MP may be contraindicated in patients with known heart disease"" implies that there is a potential risk or adverse effect associated with using high-dose MP in patients with heart disease. This suggests that MP could have some effect on heart health, whether beneficial or harmful. However, it doesn't necessarily mean that MP treats heart disorders; it could also mean that it exacerbates them. Further investigation would be needed to determine the specific nature of MP's effect on heart disorders." -25366540,Methylprednisolone treats myopathy,1243,PURPOSE: To report the therapeutic efficacy of intravenous methylprednisolone (IVMP) in patients with restrictive myopathy caused by thyroid eye disease (TED).,True,Is the triple 'Methylprednisolone treats myopathy' supported by the sentence: 'PURPOSE: To report the therapeutic efficacy of intravenous methylprednisolone (IVMP) in patients with restrictive myopathy caused by thyroid eye disease (TED).'?,"Yes, the statement does provide indirect support for the phrase ""Methylprednisolone treats myopathy"". The purpose of the study explicitly states that it is investigating the therapeutic efficacy of intravenous methylprednisolone (IVMP) in patients with restrictive myopathy caused by thyroid eye disease (TED). This implies that methylprednisolone is being used as a treatment for myopathy in this specific context, thus lending indirect support to the claim that methylprednisolone can be used to treat myopathy. However, it is important to note that myopathy is a broad term used to describe muscle diseases, and effectiveness in one type does not necessarily imply effectiveness in all types. Therefore, further investigation would be required to make a definitive conclusion about methylprednisolone's efficacy in treating all forms of myopathy." -24273559,Methylprednisolone treats Abdominal pain,1244,"After 2 months of treatment with systemic methylprednisolone, cyclophosphamide, and prednisone, the patient's abdominal pain was relieved.",True,"Is the triple 'Methylprednisolone treats Abdominal pain' supported by the sentence: 'After 2 months of treatment with systemic methylprednisolone, cyclophosphamide, and prednisone, the patient's abdominal pain was relieved.'?","Yes, indirectly it does support that statement. The relief in abdominal pain experienced by the patient could be attributed to methylprednisolone as it is one of the medications administered in the treatment regimen mentioned in the statement. However, it is important to note that there are other drugs involved (cyclophosphamide and prednisone), making it impossible to attribute the pain relief solely to methylprednisolone without further investigation. This is an example of correlation but not necessarily causation in action as multiple factors may have contributed to the alleviation of the patient's symptoms." -23772707,Methylprednisolone treats cardiac arrest,1245,Effect of Vasopressin and Methylprednisolone vs Placebo on Return of Spontaneous Circulation in Patients With In-Hospital Cardiac Arrest: A Randomized Clinical Trial.,True,Is the triple 'Methylprednisolone treats cardiac arrest' supported by the sentence: 'Effect of Vasopressin and Methylprednisolone vs Placebo on Return of Spontaneous Circulation in Patients With In-Hospital Cardiac Arrest: A Randomized Clinical Trial.'?,"Yes, the statement ""Effect of Vasopressin and Methylprednisolone vs Placebo on Return of Spontaneous Circulation in Patients With In-Hospital Cardiac Arrest: A Randomized Clinical Trial"" does lend indirect support to the claim that Methylprednisolone treats cardiac arrest. The study is designed as a randomized clinical trial comparing vasopressin and methylprednisolone against placebo in patients who have experienced in-hospital cardiac arrest. The primary outcome measures include return of spontaneous circulation (ROSC) and survival at hospital discharge. + However, it is important to note that while this statement offers some support for methylprednisolone being used in MS treatment, it does not necessarily prove that methylprednisolone is solely responsible for treating MS nor does it establish its efficacy as a primary therapy for MS management on its own. Further studies would be required to make such conclusions. + References: - While it is important to note that correlation does not imply causation, it is plausible that methylprednisolone may contribute positively towards treating cardiac arrest based on the design and objectives of the study. However, definitive conclusions cannot be drawn without examining the full text of the study as it would provide more context regarding methylprednisolone's specific efficacy in treating cardiac arrest as well as potential side effects or limitations associated with its use in such contexts." -23209303,Methylprednisolone treats respiratory system disorder,1246,"Although methylprednisolone gradually improved her respiratory condition, her oxygenation and exercise tolerance had drastically deteriorated, necessitating high-flow nasal cannula oxygen therapy.",False,"Is the triple 'Methylprednisolone treats respiratory system disorder' supported by the sentence: 'Although methylprednisolone gradually improved her respiratory condition, her oxygenation and exercise tolerance had drastically deteriorated, necessitating high-flow nasal cannula oxygen therapy.'?","No, the statement does not provide direct support for the phrase ""Methylprednisolone treats respiratory system disorder"". The information given suggests that methylprednisolone had some positive effect on the patient's respiratory condition, but it does not confirm that methylprednisolone is a treatment for respiratory system disorders. The deterioration of her oxygenation and exercise tolerance despite methylprednisolone use indicates that methylprednisolone might not be sufficient as a standalone treatment for respiratory system disorders. + [1] Sorensen PS, Frederiksen JL." +7649490,Methylprednisolone treats aplastic anemia,1304,"Neutropenic infections are the major cause of morbidity and mortality in the treatment of aplastic anemia (AA) with antilymphocyte globulin (ALG), cyclosporin A (CSA), and methylprednisolone (MP).",True,"'Does the phrase ""Methylprednisolone treats aplastic anemia"" receive at least indirect support from the statement: ""Neutropenic infections are the major cause of morbidity and mortality in the treatment of aplastic anemia (AA) with antilymphocyte globulin (ALG), cyclosporin A (CSA), and methylprednisolone (MP).""?","Yes, indirectly it does provide some support for the statement that methylprednisolone treats aplastic anemia (AA). The provided statement mentions methylprednisolone in conjunction with other treatments for AA, implying its use in treating AA. However, it does not explicitly state that methylprednisolone treats AA, nor does it provide direct evidence of its efficacy in doing so. - To establish methylprednisolone as a treatment for respiratory system disorders, further investigation would be required, including controlled clinical trials that compare methylprednisolone treatment outcomes to those of placebo groups or standard treatments for respiratory system disorders. The gold standard for determining treatment efficacy is through randomized controlled trials that establish causality between treatment interventions (methylprednisolone) and improved patient outcomes for respiratory system disorders." -23116362,Methylprednisolone treats pneumocystosis,1247,"Caspofungin, TMP-SMX, clindamycin and MP were used to treat P. jirovecii pneumonia (PJP).",True,"Is the triple 'Methylprednisolone treats pneumocystosis' supported by the sentence: 'Caspofungin, TMP-SMX, clindamycin and MP were used to treat P. jirovecii pneumonia (PJP).'?","Yes, indirectly it does support that Methylprednisolone (MP) can be used to treat pneumocystosis caused by P. jirovecii pneumonia (PJP). The statement mentions MP along with other antimicrobial agents for treating PJP, which implies that MP is part of the treatment regimen for pneumocystosis. + To elaborate, AA is often treated using immunosuppressive therapy (IST), which typically involves ALG, CSA, and sometimes corticosteroids like methylprednisolone. The rationale behind using these drugs is that they can suppress the immune system, potentially reducing immune-mediated destruction of hematopoietic stem cells in AA patients. - However, it is important to note that MP is not an antimicrobial agent itself but rather an anti-inflammatory steroid that is often used in conjunction with antimicrobials in treating PJP to manage immune-mediated injury in response to infection. Thus, while MP does have an essential role in treating pneumocystosis caused by PJP, it is not typically used alone but rather as part of a broader treatment strategy that includes antimicrobials specifically targeting P. jirovecii." -22495912,Methylprednisolone treats myocarditis,1248,"Although, not described in the literature, we have found conjunctive use of milrinone and methylprednisolone effective in patient with SARS-CoV-2 fulminant myocarditis.",True,"Is the triple 'Methylprednisolone treats myocarditis' supported by the sentence: 'Although, not described in the literature, we have found conjunctive use of milrinone and methylprednisolone effective in patient with SARS-CoV-2 fulminant myocarditis.'?","Yes, the statement does provide indirect support for the claim that methylprednisolone treats myocarditis. The statement suggests that methylprednisolone has been used in conjunction with milrinone for treating fulminant myocarditis in a patient with SARS-CoV-2 infection. This implies that methylprednisolone has some therapeutic effect on myocarditis in at least one documented case. However, it is important to note that this evidence is anecdotal and not derived from controlled clinical trials; thus, it cannot be considered definitive proof that methylprednisolone is an effective treatment for myocarditis. To establish stronger evidence for its efficacy, randomized controlled trials would be required." -19962298,Methylprednisolone treats Hodgkins lymphoma,1249,High incidence of aseptic hip necrosis in Hodgkin lymphoma patients treated with escalated BEACOPP receiving methylprednisolone.,False,Is the triple 'Methylprednisolone treats Hodgkins lymphoma' supported by the sentence: 'High incidence of aseptic hip necrosis in Hodgkin lymphoma patients treated with escalated BEACOPP receiving methylprednisolone.'?,"No, the statement does not provide indirect support for the claim that ""Methylprednisolone treats Hodgkin lymphoma"". + However, it is important to note that while methylprednisolone may be used in treating AA as part of an IST regimen, its specific therapeutic effect in AA has not been definitively established in clinical trials. Furthermore, its use in treating AA is generally considered secondary to ALG and CSA due to their more direct effects on immune function in AA patients. - The original statement discusses the high incidence of aseptic hip necrosis in Hodgkin lymphoma patients treated with escalated BEACOPP (a chemotherapy regimen) who also received methylprednisolone. This information is more indicative of a side effect or complication associated with the treatment rather than its therapeutic efficacy against Hodgkin lymphoma. + Therefore, while" +7552935,Methylprednisolone treats Inflammation,1305,Methylprednisolone treatment resulted in the greatest reduction in the inflammatory cell infiltrate but the numbers of infected neurons did not increase concomitantly.,True,"'Does the phrase ""Methylprednisolone treats Inflammation"" receive at least indirect support from the statement: ""Methylprednisolone treatment resulted in the greatest reduction in the inflammatory cell infiltrate but the numbers of infected neurons did not increase concomitantly.""?","Yes, the statement ""Methylprednisolone treats inflammation"" does receive indirect support from the provided evidence. The statement ""Methylprednisolone treatment resulted in the greatest reduction in the inflammatory cell infiltrate but the numbers of infected neurons did not increase concomitantly"" suggests that Methylprednisolone has an impact on inflammation (inflammatory cell infiltrate), which aligns with the general understanding that Methylprednisolone is used as an anti-inflammatory drug. However, it's important to note that this evidence is specific to the context of infected neurons and doesn't necessarily generalize to all inflammation scenarios. Also, while the statement supports the anti-inflammatory effect of Methylprednisolone, it doesn't explicitly state that Methylprednisolone treats inflammation, as treatment often implies resolution of the condition, not just mitigation of one of its symptoms." +7483648,Methylprednisolone treats adult acute respiratory distress syndrome,1306,Severe systemic inflammatory response syndrome with shock and ARDS resulting from Still's disease: clinical response with high-dose pulse methylprednisolone therapy.,True,"'Does the phrase ""Methylprednisolone treats adult acute respiratory distress syndrome"" receive at least indirect support from the statement: ""Severe systemic inflammatory response syndrome with shock and ARDS resulting from Still's disease: clinical response with high-dose pulse methylprednisolone therapy.""?","Yes, indirect support can be inferred from the statement provided. The user statement describes a case of adult respiratory distress syndrome (ARDS) in the context of Still's disease, which was treated successfully using high-dose pulse methylprednisolone therapy. This suggests that methylprednisolone may have therapeutic benefits for ARDS in certain clinical contexts, such as when it is caused by Still's disease. However, it is important to note that this does not provide direct evidence that methylprednisolone is an effective treatment for all cases of adult acute respiratory distress syndrome (ARDS). Further studies would be needed to establish the efficacy of methylprednisolone in different patient populations and under various disease conditions that can lead to ARDS." +7432980,Methylprednisolone treats myelodysplastic syndrome,1307,Eosinophilic fasciitis associated with autoimmune thyroid disease and myelodysplasia treated with pulsed methylprednisolone and antihistamines.,True,"'Does the phrase ""Methylprednisolone treats myelodysplastic syndrome"" receive at least indirect support from the statement: ""Eosinophilic fasciitis associated with autoimmune thyroid disease and myelodysplasia treated with pulsed methylprednisolone and antihistamines.""?","Yes, indirectly it does lend some support. The statement mentions that methylprednisolone was used to treat eosinophilic fasciitis associated with myelodysplasia (a type of myelodysplastic syndrome). However, it's important to note that myelodysplastic syndrome is a group of diverse disorders, so this doesn't necessarily mean that methylprednisolone would be effective for all types of myelodysplastic syndrome. Furthermore, the treatment was given in combination with antihistamines, so it's unclear what specific effect methylprednisolone had on the myelodysplasia. Therefore, while there is some indirect support, more specific evidence would be needed to definitively say that methylprednisolone treats myelodysplastic syndrome." +16097513,Cefotaxime treats osteomyelitis,1308,Cefotaxime in the treatment of chronic osteomyelitis caused by gram-negative bacilli.,True,"'Does the phrase ""Cefotaxime treats osteomyelitis"" receive at least indirect support from the statement: ""Cefotaxime in the treatment of chronic osteomyelitis caused by gram-negative bacilli.""?","Yes, the phrase ""Cefotaxime treats osteomyelitis"" does receive indirect support from the statement ""Cefotaxime in the treatment of chronic osteomyelitis caused by gram-negative bacilli."" This is because osteomyelitis is an inflammation of bone marrow, often caused by bacterial infection [1]. The statement specifically mentions Cefotaxime being used in the treatment of chronic osteomyelitis caused by gram-negative bacilli. Cefotaxime is an antibiotic that works by killing sensitive bacteria [2]. Therefore, it indirectly supports that Cefotaxime can treat osteomyelitis caused by gram-negative bacilli. However, it is important to note that there might be other types of bacteria causing osteomyelitis that Cefotaxime might not be effective against. - Methylprednisolone is a glucocorticoid steroid commonly used in cancer treatment for its anti-inflammatory and immunosuppressive properties, which can help manage side effects from chemotherapy or reduce tumor-associated symptoms. However, its use as a standalone treatment for Hodgkin lymphoma is not suggested by this statement. + References: + 1. ""Osteomyelitis."" Mayo Clinic, Mayo Foundation for Medical Education and Research, 15 Jan. 2021, www.mayoclinic.org/diseases-conditions/osteomyelitis/symptoms" +15119078,Cefotaxime treats peritonitis,1309,Aztreonam and cefotaxime were compared in 44 cirrhotic patients who had 52 episodes of gram-negative spontaneous peritonitis.,True,"'Does the phrase ""Cefotaxime treats peritonitis"" receive at least indirect support from the statement: ""Aztreonam and cefotaxime were compared in 44 cirrhotic patients who had 52 episodes of gram-negative spontaneous peritonitis.""?","Yes, indirectly it does. The statement provides evidence that cefotaxime has been used in clinical trials involving patients with peritonitis caused by gram-negative bacteria, which is often associated with cirrhosis. Therefore, one could infer that cefotaxime is a potential treatment for peritonitis based on this study. However, it's important to note that this is an indirect inference because the study is comparing cefotaxime to another antibiotic (aztreonam), not explicitly testing its effectiveness against peritonitis. Furthermore, while cefotaxime may be effective for gram-negative peritonitis, it may not be as effective for other types of peritonitis caused by different bacterial strains. Therefore, while there is some support for the claim, it is not unequivocal evidence that cefotaxime is an effective treatment for peritonitis." +11176033,Cefotaxime treats Sepsis,1310,"Due to the apparent volumes of distribution obtained (ranging from 0.48 to 0.51 L/kg), considering the overall clinical efficacy obtained (90% for the 10 mg/kg dose and 75% for the 20 mg/kg dose), and due to the rapid improvement observed after a few doses of the drug (1.8 to 2.5 doses to 'clinical improvement'), it is safe to postulate such doses of cefotaxime as excellent choices for the treatment of septicaemia in dogs.",True,"'Does the phrase ""Cefotaxime treats Sepsis"" receive at least indirect support from the statement: ""Due to the apparent volumes of distribution obtained (ranging from 0.48 to 0.51 L/kg), considering the overall clinical efficacy obtained (90% for the 10 mg/kg dose and 75% for the 20 mg/kg dose), and due to the rapid improvement observed after a few doses of the drug (1.8 to 2.5 doses to 'clinical improvement'), it is safe to postulate such doses of cefotaxime as excellent choices for the treatment of septicaemia in dogs.""?","Yes, the statement does provide indirect support for the phrase ""Cefotaxime treats Sepsis"" in dogs. The statement discusses a clinical study where cefotaxime was administered to dogs suffering from septicaemia (a severe form of sepsis) at two different doses. The results showed that both doses had high clinical efficacy (90% for 10 mg/kg and 75% for 20 mg/kg), suggesting that cefotaxime can be an effective treatment for septicaemia in dogs. + + Furthermore, the rapid improvement observed after just 1.8 to 2.5 doses indicates that cefotaxime can quickly alleviate symptoms of septicaemia, supporting its use as a treatment option for sepsis in dogs. However, it is essential to note that while the statement provides some evidence for cefotaxime being an effective treatment for sepsis in dogs, it is based on a single study in dogs suffering from septicaemia (a specific type of sepsis). Therefore, further studies would" +8153267,Cefotaxime treats bacterial infectious disease,1311,These results suggest that amoxicillin-clavulanic acid is an effective alternative to cefotaxime for the empirical treatment of bacterial infections in cirrhosis.,False,"'Does the phrase ""Cefotaxime treats bacterial infectious disease"" receive at least indirect support from the statement: ""These results suggest that amoxicillin-clavulanic acid is an effective alternative to cefotaxime for the empirical treatment of bacterial infections in cirrhosis.""?","No, the statement does not provide direct or indirect support for the phrase ""Cefotaxime treats bacterial infectious disease."" The statement discusses an alternative treatment (amoxicillin-clavulanic acid) to cefotaxime for bacterial infections in cirrhosis patients, implying that cefotaxime is indeed effective against bacterial infections. However, it does not offer any new evidence or confirmation that cefotaxime itself treats bacterial infectious disease. The original claim remains unsupported by the provided statement." +26980543,Ceftriaxone treats Lyme disease,1312,"Most children had received prolonged and repeated courses of oral antimicrobials and/or home intravenous infusion of antimicrobials; 79% had been hospitalized for treatment of suspected LD or management of treatment complications, most notably drug-induced symptoms of gallbladder disease occurring in patients receiving ceftriaxone (Rocephin), and bloodstream infections associated with intravenous catheters.",False,"'Does the phrase ""Ceftriaxone treats Lyme disease"" receive at least indirect support from the statement: ""Most children had received prolonged and repeated courses of oral antimicrobials and/or home intravenous infusion of antimicrobials; 79% had been hospitalized for treatment of suspected LD or management of treatment complications, most notably drug-induced symptoms of gallbladder disease occurring in patients receiving ceftriaxone (Rocephin), and bloodstream infections associated with intravenous catheters.""?","No, the statement does not provide indirect support for the claim that Ceftriaxone treats Lyme disease (LD). The passage describes symptoms and complications experienced by children undergoing LD treatment which includes Ceftriaxone (Rocephin), but it does not demonstrate that Ceftriaxone is an effective treatment for Lyme disease itself. Instead, it highlights adverse effects associated with its use in treating LD complications." +26401802,Ceftriaxone treats Sepsis,1313,"Clinical study of Rocephin, a 3d generation cephalosporin, in various septicaemias.",True,"'Does the phrase ""Ceftriaxone treats Sepsis"" receive at least indirect support from the statement: ""Clinical study of Rocephin, a 3d generation cephalosporin, in various septicaemias.""?","Yes, indirectly it does lend some support. The statement mentions Rocephin (ceftriaxone) being used in various septicaemias (a synonym for sepsis) in a clinical study. This suggests that ceftriaxone has been tested for treating sepsis, even if it doesn't provide specific efficacy or outcome details from that study. However, it is crucial to note that indirect support does not equate to definitive proof of effectiveness, as more information is needed about the study design, results, and other contextual factors for a robust evaluation of ceftriaxone's efficacy in treating sepsis." +18413392,Ceftriaxone treats bacterial pneumonia,1314,"The objectives of this open, prospective, randomized and comparative study were to evaluate and compare the efficacy and safety of intravenous ceftriaxone (active ingredient of Rocephin) and cefotaxime in treatment of bacterial pneumoniae.",True,"'Does the phrase ""Ceftriaxone treats bacterial pneumonia"" receive at least indirect support from the statement: ""The objectives of this open, prospective, randomized and comparative study were to evaluate and compare the efficacy and safety of intravenous ceftriaxone (active ingredient of Rocephin) and cefotaxime in treatment of bacterial pneumoniae.""?","Yes, the statement does provide indirect support for the phrase ""Ceftriaxone treats bacterial pneumonia"". The study mentioned in the statement is designed to evaluate and compare the efficacy and safety of intravenous ceftriaxone (the active ingredient in Rocephin) and cefotaxime in treating bacterial pneumonia. This implies that ceftriaxone is being used as a treatment option for bacterial pneumonia in the context of this study. However, it's important to note that indirect support does not equate to definitive proof. The results of the study would need to be analyzed to determine whether ceftriaxone is indeed an effective treatment for bacterial pneumonia." +25810060,Gefarnate treats gastric ulcer,1315,Clinical trial of Gefarnate in the treatment of gastric ulcer disease.,True,"'Does the phrase ""Gefarnate treats gastric ulcer"" receive at least indirect support from the statement: ""Clinical trial of Gefarnate in the treatment of gastric ulcer disease.""?","Yes, the phrase ""Gefarnate treats gastric ulcer"" does receive indirect support from the statement: ""Clinical trial of Gefarnate in the treatment of gastric ulcer disease."" - It is important to differentiate between side effects or complications related to treatments from evidence supporting their therapeutic efficacy in order to maintain accuracy in interpreting scientific statements and ensuring appropriate medical decision-making based" -19674675,Methylprednisolone treats microscopic polyangiitis,1250,Six newly diagnosed patients with MPA were initially treated with methylprednisolone and a single dose of RTX (375 mg/m2).,True,Is the triple 'Methylprednisolone treats microscopic polyangiitis' supported by the sentence: 'Six newly diagnosed patients with MPA were initially treated with methylprednisolone and a single dose of RTX (375 mg/m2).'?,"Yes, indirectly it does support that methylprednisolone treats microscopic polyangiitis (MPA). The statement indicates that six newly diagnosed MPA patients were treated with methylprednisolone as part of their initial treatment regimen. However, since there is no comparative group in this study design, it doesn't provide direct evidence that methylprednisolone is superior to other treatments for MPA. Further studies would be needed to establish whether methylprednisolone has superior efficacy compared to alternative treatments for MPA." -19534575,Methylprednisolone treats anterior ischemic optic neuropathy,1251,Early Methylprednisolone Treatment Can Stabilize the Blood-Optic Nerve Barrier in a Rat Model of Anterior Ischemic Optic Neuropathy (rAION).,True,Is the triple 'Methylprednisolone treats anterior ischemic optic neuropathy' supported by the sentence: 'Early Methylprednisolone Treatment Can Stabilize the Blood-Optic Nerve Barrier in a Rat Model of Anterior Ischemic Optic Neuropathy (rAION).'?,"Yes, indirectly it does lend some support. The statement suggests that methylprednisolone treatment can stabilize the blood-optic nerve barrier in a rat model of anterior ischemic optic neuropathy (rAION). This implies that methylprednisolone has a positive effect on rAION in rats. While this doesn't explicitly state that methylprednisolone treats anterior ischemic optic neuropathy in humans, it does suggest a potential therapeutic effect that could be further investigated in clinical trials. However, it's important to note that results from animal models don't always translate directly to humans due to differences in physiology and pathophysiology. Therefore, further research is needed before definitively stating that methylprednisolone treats anterior ischemic optic neuropathy in humans." -18427985,Methylprednisolone treats osteoarthritis,1252,"We report a case of a 68-year-old woman who presented with severe abdominal pain, nausea and vomiting, 3 days after the initiation of low-dose methylprednisolone for osteoarthritis.",False,"Is the triple 'Methylprednisolone treats osteoarthritis' supported by the sentence: 'We report a case of a 68-year-old woman who presented with severe abdominal pain, nausea and vomiting, 3 days after the initiation of low-dose methylprednisolone for osteoarthritis.'?","No, the statement does not provide direct or indirect support for the claim that methylprednisolone treats osteoarthritis. The provided statement describes an adverse reaction experienced by a patient who started taking methylprednisolone for osteoarthritis treatment. It does not demonstrate any therapeutic benefits of methylprednisolone for osteoarthritis. + The conduct of a clinical trial implies that there is some level of investigation into the potential therapeutic effects of Gefarnate for gastric ulcer disease. While this does not constitute definitive proof of its efficacy, it does suggest that there is some basis for exploring this possibility. In other words, if there were no biological plausibility for Gefarnate treating gastric ulcers, it is unlikely that a clinical trial would be conducted in the first place. Therefore, the statement lends credence to the idea that Gefarnate may have beneficial effects in treating gastric ulcers, even if it does not confirm it outright." +25784688,Gefarnate treats duodenal ulcer,1316,[Clinicobiological evolution of duodenal ulcer treated with gefarnate].,True,"'Does the phrase ""Gefarnate treats duodenal ulcer"" receive at least indirect support from the statement: ""[Clinicobiological evolution of duodenal ulcer treated with gefarnate].""?","Yes, the phrase ""Gefarnate treats duodenal ulcer"" does receive indirect support from the statement: ""[Clinicobiological evolution of duodenal ulcer treated with gefarnate]."" - To provide indirect support for methylprednisolone treating osteoarthritis, we would need information suggesting that the patient improved after continuing methylprednisolone treatment despite the initial adverse reaction. However, no such information is provided in the statement. In fact, it implies that methylprednisolone may not be suitable for all osteoarthritis patients due to potential adverse effects." -18276332,Methylprednisolone treats plantar fasciitis,1253,OBJECTIVES: To compare the effectiveness of oral nonsteroidal antiinflammatory drugs (NSAIDs) and locally injectable steroid (methylprednisolone) in the treatment of plantar fasciitis.,True,Is the triple 'Methylprednisolone treats plantar fasciitis' supported by the sentence: 'OBJECTIVES: To compare the effectiveness of oral nonsteroidal antiinflammatory drugs (NSAIDs) and locally injectable steroid (methylprednisolone) in the treatment of plantar fasciitis.'?,"Yes, the statement does provide indirect support for the phrase ""Methylprednisolone treats plantar fasciitis."" The objective of the study mentioned is to compare the effectiveness of nonsteroidal antiinflammatory drugs (NSAIDs) and locally injectable steroid (methylprednisolone) in treating plantar fasciitis. This implies that methylprednisolone is being considered as a treatment option for plantar fasciitis, thus supporting the notion that methylprednisolone can be used for treating plantar fasciitis, directly or indirectly. + The title of the study suggests that gefarnate was used in the treatment of duodenal ulcers. While it does not explicitly state that gefarnate treats duodenal ulcers, the context implies that gefarnate has some therapeutic effect on duodenal ulcers as it is being used in their treatment within the study. However, it is important to note that a single study title is not sufficient evidence to make definitive conclusions about a treatment's efficacy. A thorough review of the study's methods, results, and conclusions would be necessary to provide more robust support for such a claim." +19702373,Gefarnate treats peptic ulcer disease,1317,"One hundred and thirty-nine patients with endoscopically confirmed peptic ulcers (gastric and duodenal) entered a double blind comparative evaluation of alprazolam (1.2 mg/day), gefarnate (300 mg/day) and their combination in treatment of peptic ulcer.",True,"'Does the phrase ""Gefarnate treats peptic ulcer disease"" receive at least indirect support from the statement: ""One hundred and thirty-nine patients with endoscopically confirmed peptic ulcers (gastric and duodenal) entered a double blind comparative evaluation of alprazolam (1.2 mg/day), gefarnate (300 mg/day) and their combination in treatment of peptic ulcer.""?","Yes, the statement does provide indirect support for the claim that gefarnate treats peptic ulcer disease. The reason is that the statement mentions gefarnate being used in a double-blind comparative evaluation specifically for patients with endoscopically confirmed peptic ulcers (gastric and duodenal). This implies that there is an interest in studying gefarnate as a potential treatment for peptic ulcers, which would not be the case if it did not have some theoretical basis for treating the condition. However, it is important to note that indirect support does not equate to definitive proof of effectiveness; it merely suggests that further investigation is warranted based on some preliminary evidence or rationale." +22023951,Regadenoson treats coronary artery disorder,1318,CONCLUSIONS: Regadenoson may be a safe vasodilator for CTP and MR MPI in CAD patients.,True,"'Does the phrase ""Regadenoson treats coronary artery disorder"" receive at least indirect support from the statement: ""CONCLUSIONS: Regadenoson may be a safe vasodilator for CTP and MR MPI in CAD patients.""?","Yes, there is indirect support for the phrase ""Regadenoson treats coronary artery disorder"" in the statement ""CONCLUSIONS: Regadenoson may be a safe vasodilator for CTP and MR MPI in CAD patients."" - However, it is essential to note that indirect support does not equate to definitive evidence for the claim made in isolation. The effectiveness, safety profile, dosage, duration, and other factors must be considered in conjunction with other pieces of evidence when assessing whether methylprednisolone is an appropriate treatment for plantar fasciitis." -18008318,Methylprednisolone treats dermatomyositis,1254,A Japanese woman was treated with injectable methylprednisolone and oral prednisolone for dermatomyositis.,True,Is the triple 'Methylprednisolone treats dermatomyositis' supported by the sentence: 'A Japanese woman was treated with injectable methylprednisolone and oral prednisolone for dermatomyositis.'?,"Yes, the statement does provide indirect support for the claim that methylprednisolone treats dermatomyositis. The Japanese woman was treated for dermatomyositis using methylprednisolone as one of her medications, which suggests that methylprednisolone is an effective treatment for dermatomyositis. However, it is important to note that correlation does not imply causation; in other words, we cannot definitively conclude that methylprednisolone was solely responsible for treating her dermatomyositis based on this statement alone. Further evidence is required before making such an assertion. + The term ""CAD"" in the conclusion stands for Coronary Artery Disease, which is a type of coronary artery disorder. The statement suggests that Regadenoson may be safe for use in CAD patients during Cardiac Magnetic Resonance (MR) Myocardial Perfusion Imaging (MPI) and Coronary Computed Tomography (CT) Perfusion (CTP). This implies that Regadenoson could potentially have a therapeutic effect in treating coronary artery disorders by improving diagnostic imaging and thus guiding treatment decisions. However, it's important to note that this is an indirect inference, as the statement does not explicitly claim that Regadenoson treats coronary artery disorder, but rather that it may be safe for use in diagnostic procedures for such patients." +13297277,Meldonium treats Ischemic stroke,1319,A study is presented of the clinico-hemodynamic efficacy of mildronate in 38 patients with ischemic stroke.,False,"'Does the phrase ""Meldonium treats Ischemic stroke"" receive at least indirect support from the statement: ""A study is presented of the clinico-hemodynamic efficacy of mildronate in 38 patients with ischemic stroke.""?","No, the statement does not provide indirect support for the phrase ""Meldonium treats Ischemic stroke."" The study investigates the clinico-hemodynamic efficacy of mildronate in patients with ischemic stroke; however, it does not establish that meldonium treats ischemic stroke. Meldonium is also known as mildronate, but demonstrating clinico-hemodynamic efficacy is not equivalent to proving that it treats ischemic stroke as treating implies causality in curing or alleviating symptoms of the disease, which is not explicitly shown in the statement. - In addition, it is worth noting that injectable methylprednisolone was used in combination with oral prednisolone in this case. While both medications belong to the same class (glucocorticoids) and can be used interchangeably in treating dermatomyositis, it is difficult to isolate methylprednisolone as the sole effective treatment in this instance due to their combined usage. Nonetheless, it does suggest that methylprednisolone is an effective therapeutic option for dermatomyositis patients when" -17478785,Methylprednisolone treats nasal cavity polyp,1255,"The study by Van Zele et al reports positive results for a randomized, double-blind, placebo-controlled trial that used either 20 days of doxycycline (200 mg the first day, followed by 100 mg daily) or 20 days of a tapering schedule of methyl prednisolone (32 mg on days 1-5, 16 mg on days 6-10, and 8 mg on days 11-20) for the treatment of nasal polyps.",True,"Is the triple 'Methylprednisolone treats nasal cavity polyp' supported by the sentence: 'The study by Van Zele et al reports positive results for a randomized, double-blind, placebo-controlled trial that used either 20 days of doxycycline (200 mg the first day, followed by 100 mg daily) or 20 days of a tapering schedule of methyl prednisolone (32 mg on days 1-5, 16 mg on days 6-10, and 8 mg on days 11-20) for the treatment of nasal polyps.'?","Yes, the statement does provide indirect support for the claim that methylprednisolone treats nasal cavity polyps. The study by Van Zele et al reports positive results from a randomized, double-blind, placebo-controlled trial where methylprednisolone was used in a tapering schedule for 20 days to treat nasal polyps. However, it is important to note that direct causality cannot be inferred solely based on this information, as further investigation into the specific effects of methylprednisolone on nasal polyps would be required for a definitive conclusion." -15407991,Methylprednisolone treats radiculopathy,1256,"Herein, we present our experience of management of such cases with a single epidural injection of local anaesthetic, tramadol and methylprednisolone, and table tilt for management of both radiculopathies.",True,"Is the triple 'Methylprednisolone treats radiculopathy' supported by the sentence: 'Herein, we present our experience of management of such cases with a single epidural injection of local anaesthetic, tramadol and methylprednisolone, and table tilt for management of both radiculopathies.'?","Yes, the statement does provide indirect support for the phrase ""Methylprednisolone treats radiculopathy"". This is because methylprednisolone is mentioned as one of the components in the epidural injection used in managing radiculopathies in the provided statement. However, it is important to note that correlation does not imply causation; while methylprednisolone may be used in treating radiculopathy, it does not necessarily mean that it is the sole active ingredient responsible for symptom relief. Further evidence from controlled clinical trials would be needed to establish a direct causal relationship between methylprednisolone and radiculopathy treatment." -14897628,Methylprednisolone treats neuromyelitis optica,1257,Early high-dose intravenous methylprednisolone is effective in preserving retinal nerve fiber layer thickness in patients with neuromyelitis optica.,True,Is the triple 'Methylprednisolone treats neuromyelitis optica' supported by the sentence: 'Early high-dose intravenous methylprednisolone is effective in preserving retinal nerve fiber layer thickness in patients with neuromyelitis optica.'?,"Yes, the statement does provide indirect support for the claim that methylprednisolone treats neuromyelitis optica (NMO). The statement suggests that early high-dose intravenous methylprednisolone is effective in preserving retinal nerve fiber layer thickness in patients with NMO. This implies that methylprednisolone has some therapeutic effect on NMO, thus supporting the broader claim that it can be used to treat NMO. However, it is important to note that treating symptoms (preserving retinal nerve fiber layer thickness) is not the same as treating the underlying disease (NMO). Therefore, while there is some level of support, it is not direct support for the claim that methylprednisolone treats NMO." -14825096,Methylprednisolone treats West syndrome,1258,The authors report their experience with intravenous methylprednisolone for the treatment of infantile spasms.,True,Is the triple 'Methylprednisolone treats West syndrome' supported by the sentence: 'The authors report their experience with intravenous methylprednisolone for the treatment of infantile spasms.'?,"Yes, the statement ""The authors report their experience with intravenous methylprednisolone for the treatment of infantile spasms"" does provide indirect support for the claim that ""Methylprednisolone treats West syndrome."" West syndrome is an eponym for infantile spasms, which is a specific type of epileptic seizure disorder in infants and young children. The statement from the authors indicates their use of methylprednisolone as a treatment for infantile spasms, suggesting that methylprednisolone has therapeutic potential for West syndrome. However, it is important to note that indirect support does not equate to definitive proof, as more extensive clinical trials would be required to establish methylprednisolone as an evidence-based treatment for West syndrome." -14690661,Methylprednisolone treats Meniere disease,1259,OBJECTIVE: To describe the long-term efficacy of transtympanic steroids (TTS) using methyl-prednisolone in the treatment of Meniere's disease (MD).,True,Is the triple 'Methylprednisolone treats Meniere disease' supported by the sentence: 'OBJECTIVE: To describe the long-term efficacy of transtympanic steroids (TTS) using methyl-prednisolone in the treatment of Meniere's disease (MD).'?,"Yes, the statement does provide indirect support for the phrase ""Methylprednisolone treats Meniere disease"". The objective of the study explicitly mentions using methylprednisolone as part of transtympanic steroids (TTS) treatment for Meniere's disease (MD). By investigating the long-term efficacy of TTS using methylprednisolone in treating MD, it implies that methylprednisolone could have a positive impact on Meniere disease treatment. However, it is important to note that further evaluation of the study results is necessary to make definitive conclusions about its direct support for the treatment efficacy of methylprednisolone for Meniere disease specifically." -14636779,Methylprednisolone treats neoplasm,1260,"Rats with stereotactically implanted Walker 256 tumors were treated with methylprednisolone, U-74006F, U-78517F, or vehicle (0.05 N HCl) on Days 6 through 10 following implantation.",False,"Is the triple 'Methylprednisolone treats neoplasm' supported by the sentence: 'Rats with stereotactically implanted Walker 256 tumors were treated with methylprednisolone, U-74006F, U-78517F, or vehicle (0.05 N HCl) on Days 6 through 10 following implantation.'?","No, the phrase ""Methylprednisolone treats neoplasm"" does not receive direct support from the statement provided. The statement describes an experiment where rats with implanted Walker 256 tumors were treated with various substances including methylprednisolone; however, it does not provide information on the outcomes of these treatments. Therefore, we cannot infer that methylprednisolone effectively treats neoplasm (a type of new and abnormal growth) based on this statement alone. Further information about the results of the treatments would be needed to make such a conclusion." -14398238,Methylprednisolone treats IgA glomerulonephritis,1261,"CONCLUSIONS: Methylprednisolone and cyclophosphamide in children with Grade IV IgA nephropathy stabilized renal function and significantly reduced hematuria, proteinuria, mesangial IgA deposition, and the renal pathological activity index.",True,"Is the triple 'Methylprednisolone treats IgA glomerulonephritis' supported by the sentence: 'CONCLUSIONS: Methylprednisolone and cyclophosphamide in children with Grade IV IgA nephropathy stabilized renal function and significantly reduced hematuria, proteinuria, mesangial IgA deposition, and the renal pathological activity index.'?","Yes, the statement does provide indirect support for the claim that Methylprednisolone treats IgA glomerulonephritis (IgAN), which is a form of IgA nephropathy. The conclusion states that Methylprednisolone (a type of corticosteroid) significantly reduced hematuria, proteinuria, mesangial IgA deposition, and renal pathological activity index in children with Grade IV IgAN. These improvements suggest that Methylprednisolone has therapeutic effects on IgAN. However, it is important to note that direct causality cannot be inferred from this single study alone; further evidence is needed to conclusively state that Methylprednisolone treats IgAN. + To provide indirect support for ""Meldonium treats Ischemic stroke,"" one would need additional evidence demonstrating improved patient outcomes in terms of reduced stroke recurrence, decreased disability, or enhanced neurological recovery following meldonium administration – none of which is mentioned in the statement provided." +25624167,Neobiotic treats pneumonia,1320,Use of neomycin for treatment of Rhodococcus equi pneumonia in foals.,True,"'Does the phrase ""Neobiotic treats pneumonia"" receive at least indirect support from the statement: ""Use of neomycin for treatment of Rhodococcus equi pneumonia in foals.""?","Yes, indirectly it does. The statement ""Use of neomycin for treatment of Rhodococcus equi pneumonia in foals"" suggests that neomycin, which is a type of neobiotic (an antibiotic derived from non-pathogenic bacteria or fungi), has been used effectively in treating pneumonia caused by Rhodococcus equi in foals. However, this does not necessarily mean that all types of neobiotic will be effective in treating all forms of pneumonia. It is a specific example of neobiotic use in one context. Therefore, while not providing direct support for the broad claim ""Neobiotic treats pneumonia"", it does offer indirect support by demonstrating that at least one type of neobiotic has been used successfully in treating pneumonia under certain conditions." +11022701,Neobiotic treats bacterial infectious disease with sepsis,1321,Osteomyelitis of the cervical vertebras as a complication of urinary tract disease; Proteus bacteremia treated with neomycin.,True,"'Does the phrase ""Neobiotic treats bacterial infectious disease with sepsis"" receive at least indirect support from the statement: ""Osteomyelitis of the cervical vertebras as a complication of urinary tract disease; Proteus bacteremia treated with neomycin.""?","Yes, there is indirect support for the phrase ""Neobiotic treats bacterial infectious disease with sepsis"" from the statement ""Osteomyelitis of the cervical vertebras as a complication of urinary tract disease; Proteus bacteremia treated with neomycin."" - To clarify the relationship between these two statements, let us examine what they entail: + The statement indicates that Proteus bacteremia, which is a type of bacterial infection that leads to sepsis, was treated with neomycin, which is a type of neobiotic (an antibiotic that has not been used in clinical practice for many years). This suggests that neomycin can be used to treat bacterial infectious diseases that lead to sepsis, thus providing indirect support for the claim. However, it is important to note that this is based on a single case study and further research would be needed to make more generalizable conclusions." +24398401,BLINATUMOMAB treats B-cell chronic lymphocytic leukemia,1322,Lineage Conversion in Pediatric B-Cell Precursor Acute Leukemia under Blinatumomab Therapy.,True,"'Does the phrase ""BLINATUMOMAB treats B-cell chronic lymphocytic leukemia"" receive at least indirect support from the statement: ""Lineage Conversion in Pediatric B-Cell Precursor Acute Leukemia under Blinatumomab Therapy.""?","Yes, there is indirect support for the statement that ""BLINATUMOMAB treats B-cell chronic lymphocytic leukemia"" based on the provided reference ""Lineage Conversion in Pediatric B-Cell Precursor Acute Leukemia under Blinatumomab Therapy."" - The conclusion from the study indicates that Methylprednisolone has beneficial effects on several measurable factors in children suffering from Grade IV IgAN (a severe form). These factors include reduced hematuria (blood in urine), proteinuria (protein in urine), mesang" -14232595,Methylprednisolone treats membranous glomerulonephritis,1262,"MN was treated with methylprednisolone as first-line therapy, then she was changed to rituximab for a relapse.",True,"Is the triple 'Methylprednisolone treats membranous glomerulonephritis' supported by the sentence: 'MN was treated with methylprednisolone as first-line therapy, then she was changed to rituximab for a relapse.'?","Yes, there is indirect support for the claim that methylprednisolone treats membranous glomerulonephritis (MN) based on the statement provided. The patient was initially treated with methylprednisolone as first-line therapy for MN, which suggests that methylprednisolone is an appropriate treatment option for MN. However, it is essential to recognize that this is indirect evidence because it does not explicitly demonstrate that methylprednisolone caused an improvement in MN symptoms; it only shows its use in treatment. Other factors may have influenced the decision to switch therapies, such as side effects, relapse triggers, or patient preference. Thus, while there is some support for the claim based on this statement alone, further investigation would be necessary for more definitive evidence." -14027935,Methylprednisolone treats diffuse large B-cell lymphoma,1263,"This study evaluated the influence of prior exposure to rituximab on response rates and survival in patients with diffuse large B-cell lymphoma treated with rituximab plus etoposide, cytarabine, cisplatinum and methylprednisolone (R-ESHAP).",False,"Is the triple 'Methylprednisolone treats diffuse large B-cell lymphoma' supported by the sentence: 'This study evaluated the influence of prior exposure to rituximab on response rates and survival in patients with diffuse large B-cell lymphoma treated with rituximab plus etoposide, cytarabine, cisplatinum and methylprednisolone (R-ESHAP).'?","No, the statement does not provide direct support for the claim that ""Methylprednisolone treats diffuse large B-cell lymphoma."" The study in question is investigating the impact of prior rituximab exposure on response rates in patients with diffuse large B-cell lymphoma who were treated with R-ESHAP, which includes methylprednisolone as part of its regimen. However, it does not imply that methylprednisolone is solely responsible for treating diffuse large B-cell lymphoma in isolation from other agents in the R-ESHAP protocol. + + Blinatumomab is an FDA-approved bispecific T-cell engager (BiTE) antibody construct that binds both CD3 on T-cells and CD19 on B-cells, thereby facilitating T-cell-mediated killing of CD19-expressing malignant B-cells (B-cell lymphoblastic leukemia/lymphoma). The study in question investigates Blinatumomab's effect on pediatric B-cell precursor acute lymphoblastic leukemia (BCP-ALL). + Although B-cell chronic lymphocytic leukemia (B-CLL) is not explicitly mentioned in the title, B-CLL is indeed a type of B-" +23073290,BLINATUMOMAB treats Precursor B-Cell Lymphoblastic Leukemia-Lymphoma,1323,"We report on the Australian experience of blinatumomab for treatment of 24 children with relapsed/refractory precursor B-cell acute lymphoblastic leukaemia (B-ALL) and high-risk genetics, resulting in a minimal residual disease (MRD) response rate of 58%, 2-year progression-free survival (PFS) of 39% and 2-year overall survival of 63%.",True,"'Does the phrase ""BLINATUMOMAB treats Precursor B-Cell Lymphoblastic Leukemia-Lymphoma"" receive at least indirect support from the statement: ""We report on the Australian experience of blinatumomab for treatment of 24 children with relapsed/refractory precursor B-cell acute lymphoblastic leukaemia (B-ALL) and high-risk genetics, resulting in a minimal residual disease (MRD) response rate of 58%, 2-year progression-free survival (PFS) of 39% and 2-year overall survival of 63%.""?","Yes, the statement does provide indirect support for the phrase ""BLINATUMOMAB treats Precursor B-Cell Lymphoblastic Leukemia-Lymphoma"". The statement reports on a study where blinatumomab was used to treat 24 children with relapsed/refractory precursor B-cell acute lymphoblastic leukemia (B-ALL) and high-risk genetics. The results showed that 58% of these children had a minimal residual disease (MRD) response rate, and the 2-year progression-free survival (PFS) and overall survival were 39% and 63%, respectively. These positive outcomes suggest that blinatumomab has therapeutic efficacy in treating precursor B-cell lymphoblastic leukemia-lymphoma, thus lending support to the claim. However, it is important to note that while these results are promising, they come from a single study with a relatively small sample size, so further research is needed to confirm these findings" +21932754,BLINATUMOMAB treats acute lymphoblastic leukemia,1324,"Blinatumomab for Acute Lymphoblastic Leukemia: The First Bispecific T-Cell Engager Antibody to Be Approved by the EMA for Minimal Residual Disease.On November 15, 2018, the Committee for Medicinal Products for Human Use (CHMP) recommended the extension of indication for blinatumomab to include the treatment of adults with minimal residual disease (MRD) positive B-cell precursor acute lymphoblastic leukemia (ALL).",True,"'Does the phrase ""BLINATUMOMAB treats acute lymphoblastic leukemia"" receive at least indirect support from the statement: ""Blinatumomab for Acute Lymphoblastic Leukemia: The First Bispecific T-Cell Engager Antibody to Be Approved by the EMA for Minimal Residual Disease.On November 15, 2018, the Committee for Medicinal Products for Human Use (CHMP) recommended the extension of indication for blinatumomab to include the treatment of adults with minimal residual disease (MRD) positive B-cell precursor acute lymphoblastic leukemia (ALL).""?","Yes, the statement does provide indirect support for the phrase ""BLINATUMOMAB treats acute lymphoblastic leukemia"". The Committee for Medicinal Products for Human Use (CHMP) recommending the extension of indication for blinatumomab to include treatment of adults with minimal residual disease (MRD) positive B-cell precursor acute lymphoblastic leukemia (ALL) implies that blinatumomab is an effective treatment for ALL patients who have minimal residual disease. This suggests that blinatumomab can help treat ALL by targeting residual leukemia cells that remain in the body after initial treatment, thereby reducing the risk of relapse. However, it is important to note that ""treats"" in this context refers specifically to its use in treating ALL in patients with minimal residual disease rather than ALL in general." +21720587,BLINATUMOMAB treats lymphoma,1325,"Cytokine storm was reported in four patients (19%).In conclusion, treatment with blinatumomab is effective and tolerable in adult patients with relapsed/refractory B-ALL outside of a clinical trial stetting.",True,"'Does the phrase ""BLINATUMOMAB treats lymphoma"" receive at least indirect support from the statement: ""Cytokine storm was reported in four patients (19%).In conclusion, treatment with blinatumomab is effective and tolerable in adult patients with relapsed/refractory B-ALL outside of a clinical trial stetting.""?","Yes, indirect support can be inferred from the statement provided. The conclusion that blinatumomab is effective and tolerable in adult patients with relapsed/refractory B-ALL outside of a clinical trial setting suggests that it has positive effects on treating lymphoma (B-ALL is a type of lymphoma). However, direct support for the phrase ""BLINATUMOMAB treats lymphoma"" would require a specific statement linking blinatumomab directly to treating lymphoma rather than just mentioning its effectiveness in treating B-ALL. The cytokine storm incident mentioned in four patients does not negate the effectiveness of blinatumomab but indicates a potential side effect that needs to be managed." +9387116,Ciprofloxacin physically interacts with DNA Gyrase,1326,"UNLABELLED: Ciprofloxacin, a quinolone antibiotic drug, binds to DNA topoisomerase IV and DNA gyrase of various bacteria.",True,"'Does the phrase ""Ciprofloxacin physically interacts with DNA Gyrase"" receive at least indirect support from the statement: ""UNLABELLED: Ciprofloxacin, a quinolone antibiotic drug, binds to DNA topoisomerase IV and DNA gyrase of various bacteria.""?","Yes, the phrase ""Ciprofloxacin physically interacts with DNA Gyrase"" does receive indirect support from the statement: ""UNLABELLED: Ciprofloxacin, a quinolone antibiotic drug, binds to DNA topoisomerase IV and DNA gyrase of various bacteria."" - To establish whether methylprednisolone could be an effective treatment for diffuse large B-cell lymphoma, one would need additional evidence from studies specifically designed to evaluate its therapeutic potential in treating this type of lymphoma. + The key term here is ""binds."" In molecular biology terms, binding refers to physical interaction between two molecules. Therefore, when it is stated that Ciprofloxacin binds to DNA topoisomerase IV and DNA gyrase of various bacteria, it implies that there is a physical interaction between Ciprofloxacin and these enzymes (DNA gyrase being one of them). This physical interaction can alter the function of DNA gyrase, leading to bacterial cell death - which is the desired effect of Ciprofloxacin as an antibiotic drug." +8212496,Ciprofloxacin physically interacts with DNA Gyrase,1327,Topoisomerase IV and DNA gyrase were purified from a ciprofloxacin-sensitive Streptococcus pneumoniae strain and from two clinical isolates of S. pneumoniae with high-level resistance to ciprofloxacin by means of a gene cloning method in Escherichia coli.,True,"'Does the phrase ""Ciprofloxacin physically interacts with DNA Gyrase"" receive at least indirect support from the statement: ""Topoisomerase IV and DNA gyrase were purified from a ciprofloxacin-sensitive Streptococcus pneumoniae strain and from two clinical isolates of S. pneumoniae with high-level resistance to ciprofloxacin by means of a gene cloning method in Escherichia coli.""?","Yes, indirect support can be inferred from the statement provided for the phrase ""Ciprofloxacin physically interacts with DNA Gyrase."" The statement reveals that both topoisomerase IV and DNA gyrase were purified from ciprofloxacin-sensitive as well as ciprofloxacin-resistant strains of Streptococcus pneumoniae using gene cloning methods in Escherichia coli. + Ciprofloxacin is an antibiotic from the class of fluoroquinolones that inhibits bacterial DNA gyrase (topoisomerase II) and topoisomerase IV, thereby inhibiting DNA replication and transcription. The fact that ciprofloxacin exhibits different effects on sensitive versus resistant strains of S. pneumoniae implies that these enzymes interact physically with ciprofloxacin in some capacity. - In summary, while methylprednisolone is used in treating diffuse large B-cell lymphoma as part of the R-ESHAP protocol in this study, it does not provide sufficient evidence that methylprednisolone alone can treat diffuse large" -13679356,Methylprednisolone treats hemophagocytic syndrome,1264,"A 46 year old woman who presented with severe multiorgans involvement including liver brain, cardio-pulmonary failure, gastrointestinal bleeding, progressive cytopenia, DIC and hemophagocytic syndrome during the convalescent phase of Dengue type II has been successfully treated primarily with pulse methyl prednisolone and high dose intravenous immunoglobulin G.",True,"Is the triple 'Methylprednisolone treats hemophagocytic syndrome' supported by the sentence: 'A 46 year old woman who presented with severe multiorgans involvement including liver brain, cardio-pulmonary failure, gastrointestinal bleeding, progressive cytopenia, DIC and hemophagocytic syndrome during the convalescent phase of Dengue type II has been successfully treated primarily with pulse methyl prednisolone and high dose intravenous immunoglobulin G.'?","Yes, the statement does provide indirect support for the claim that methylprednisolone treats hemophagocytic syndrome. The case report describes a patient suffering from hemophagocytic syndrome during the convalescent phase of Dengue type II who was successfully treated primarily with pulse methylprednisolone and high-dose intravenous immunoglobulin G. The fact that the patient responded positively to methylprednisolone treatment suggests that it may be an effective treatment option for hemophagocytic syndrome, although further studies would be required to establish a definitive causal relationship and determine whether methylprednisolone is superior to other treatment options for hemophagocytic syndrome. + + However, it is important to note that while indirect support can be inferred from this statement, direct experimental evidence demonstrating physical interaction between ciprofloxac" +7781719,Ciprofloxacin affects DNA Gyrase,1328,"The concentrations of ciprofloxacin, sparfloxacin, levofloxacin, or ofloxacin required to inhibit wild-type topoisomerase IV were 8 to 16 times lower than those required to inhibit wild-type DNA gyrase.",True,"'Does the phrase ""Ciprofloxacin affects DNA Gyrase"" receive at least indirect support from the statement: ""The concentrations of ciprofloxacin, sparfloxacin, levofloxacin, or ofloxacin required to inhibit wild-type topoisomerase IV were 8 to 16 times lower than those required to inhibit wild-type DNA gyrase.""?","Yes, the statement does provide indirect support for the phrase ""Ciprofloxacin affects DNA Gyrase"". The statement suggests that ciprofloxacin, along with other fluoroquinolones, inhibits wild-type topoisomerase IV at lower concentrations than those required to inhibit wild-type DNA gyrase. This implies that DNA gyrase is more resistant to inhibition by ciprofloxacin than topoisomerase IV. This resistance could be due to structural differences between these two enzymes that affect how they interact with ciprofloxacin. The fact that ciprofloxacin does inhibit DNA gyrase, albeit at higher concentrations, supports the assertion that it affects DNA gyrase. - However, it is important to note that methylprednisolone is not being used in isolation in this case; it is being administered in combination with intravenous immunoglobulin G (IVIG). Therefore, it is possible that IVIG may be contributing to the patient's recovery as well. It is also possible that other factors unrelated to treatment may have influenced the patient's outcome. + However, it is important to note that indirect evidence does not provide as strong of support as direct evidence would. Direct evidence would involve experiments specifically designed to observe the effects of ciprofloxacin on DNA gyrase in isolation from other targets like topoisomerase IV. Nonetheless, in combination with other evidence, this indirect support can contribute to a more robust understanding of c" +18400322,Ciprofloxacin affects DNA Gyrase,1329,Plasmid-encoded protein QnrB1 protects DNA gyrase from ciprofloxacin inhibition.,True,"'Does the phrase ""Ciprofloxacin affects DNA Gyrase"" receive at least indirect support from the statement: ""Plasmid-encoded protein QnrB1 protects DNA gyrase from ciprofloxacin inhibition.""?","Yes, the statement does provide indirect support for the phrase ""Ciprofloxacin affects DNA Gyrase."" The statement implies that Ciprofloxacin inhibits DNA gyrase because it mentions that plasmid-encoded protein QnrB1 protects DNA gyrase from Ciprofloxacin inhibition. This suggests that Ciprofloxacin has an effect on DNA gyrase, otherwise there would be no need for protection. - In summary, while there is some evidence" -13619118,Methylprednisolone treats chronic obstructive pulmonary disease,1265,"In conclusion, methylprednisolone in combination with conventional medical therapy not only improved lung function values but also mean nocturnal oxyhemoglobin saturation and sleep duration in clinically stabilized COPD patients who experience nocturnal oxyhemoglobin desaturation.",True,"Is the triple 'Methylprednisolone treats chronic obstructive pulmonary disease' supported by the sentence: 'In conclusion, methylprednisolone in combination with conventional medical therapy not only improved lung function values but also mean nocturnal oxyhemoglobin saturation and sleep duration in clinically stabilized COPD patients who experience nocturnal oxyhemoglobin desaturation.'?","Yes, the statement does provide indirect support for the claim that methylprednisolone treats chronic obstructive pulmonary disease (COPD). The study indicates that methylprednisolone, when used in combination with conventional medical therapy, improved lung function values and nocturnal oxyhemoglobin saturation in clinically stabilized COPD patients who experience nocturnal oxyhemoglobin desaturation. These improvements suggest that methylprednisolone has a positive impact on COPD symptoms and related complications, implying that it may be an effective treatment option for COPD patients. However, it is important to note that methylprednisolone is typically used for short-term management of exacerbations rather than long-term treatment due to potential side effects associated with prolonged steroid use. + DNA gyrase is an essential enzyme for bacterial DNA replication, transcription, and repair. Fluoroquinolones like Ciprofloxacin work by inhibiting DNA gyrase, which leads to bacterial cell death. The QnrB1 protein is known to provide protection against fluoroquinolones by binding to DNA gyrase and preventing the antibiotic from interacting with its target. This mechanism of resistance further supports the notion that Ciprofloxacin indeed affects DNA gyrase." +24010235,Ciprofloxacin treats chronic bronchitis,1330,"Thirty four patients with acute purulent exacerbations of chronic bronchitis were treated with 500 mg ciprofloxacin twice daily, orally, for ten days.",True,"'Does the phrase ""Ciprofloxacin treats chronic bronchitis"" receive at least indirect support from the statement: ""Thirty four patients with acute purulent exacerbations of chronic bronchitis were treated with 500 mg ciprofloxacin twice daily, orally, for ten days.""?","Yes, indirectly it does lend some support. The statement suggests that patients suffering from acute purulent exacerbations of chronic bronchitis were treated with Ciprofloxacin. The fact that they were treated implies that it was considered potentially beneficial for these patients, which includes those suffering from chronic bronchitis. However, it's important to note that this doesn't constitute direct evidence that Ciprofloxacin treats chronic bronchitis, as it doesn't specify whether the patients' chronic bronchitis improved as a result of the treatment. It also doesn't rule out other possible factors contributing to any potential improvement. Therefore, while suggestive, further evidence would be needed for a definitive conclusion." +22484062,Ciprofloxacin treats amyotrophic lateral sclerosis,1331,"OBJECTIVE: To evaluate the efficacy of a fixed-dose combination of two approved drugs, Ciprofloxacin and Celecoxib, as a potential therapeutic treatment for amyotrophic lateral sclerosis (ALS).",False,"'Does the phrase ""Ciprofloxacin treats amyotrophic lateral sclerosis"" receive at least indirect support from the statement: ""OBJECTIVE: To evaluate the efficacy of a fixed-dose combination of two approved drugs, Ciprofloxacin and Celecoxib, as a potential therapeutic treatment for amyotrophic lateral sclerosis (ALS).""?","No, the statement ""Ciprofloxacin treats amyotrophic lateral sclerosis"" does not receive direct or indirect support from the provided statement. The objective of the study mentioned only aims to evaluate the efficacy of a fixed-dose combination of Ciprofloxacin and Celecoxib as a potential therapeutic treatment for amyotrophic lateral sclerosis (ALS). It does not confirm that Ciprofloxacin alone treats ALS; it only indicates that further investigation is being conducted on its potential therapeutic use for that condition in combination with Celecoxib." +21488232,Ciprofloxacin treats Infection,1332,Noncytotoxic Pyrrolobenzodiazepine-Ciprofloxacin Conjugate with Activity against Mycobacterium tuberculosis .The development of new antitubercular agents for the treatment of infections caused by multidrug-resistant (MDR) Mycobacterium tuberculosis is an urgent priority.,True,"'Does the phrase ""Ciprofloxacin treats Infection"" receive at least indirect support from the statement: ""Noncytotoxic Pyrrolobenzodiazepine-Ciprofloxacin Conjugate with Activity against Mycobacterium tuberculosis .The development of new antitubercular agents for the treatment of infections caused by multidrug-resistant (MDR) Mycobacterium tuberculosis is an urgent priority.""?","Yes, there is indirect support for the phrase ""Ciprofloxacin treats Infection"" from the statement provided. The statement mentions a ""Noncytotoxic Pyrrolobenzodiazepine-Ciprofloxacin Conjugate"" that has activity against Mycobacterium tuberculosis. Ciprofloxacin is an antibiotic that belongs to the class of fluoroquinolones, which are known for their antibacterial properties. Therefore, it can be inferred that Ciprofloxacin is being used as part of a treatment for an infection caused by Mycobacterium tuberculosis in this context. However, it is important to note that direct evidence of Ciprofloxacin treating an infection is not provided in the statement; rather, it is implied by its use in conjunction with a pyrrolobenzodiazepine in an antitubercular agent." +20040173,Ciprofloxacin treats lymphoma,1333,Antibacterial prophylaxis with ciprofloxacin for patients with multiple myeloma and lymphoma undergoing autologous haematopoietic cell transplantation: a quasi-experimental single-centre before-after study.,False,"'Does the phrase ""Ciprofloxacin treats lymphoma"" receive at least indirect support from the statement: ""Antibacterial prophylaxis with ciprofloxacin for patients with multiple myeloma and lymphoma undergoing autologous haematopoietic cell transplantation: a quasi-experimental single-centre before-after study.""?","No, the phrase ""Ciprofloxacin treats lymphoma"" does not receive indirect support from the statement provided. The study mentioned is about antibacterial prophylaxis using Ciprofloxacin for patients undergoing autologous haematopoietic cell transplantation, which includes patients with multiple myeloma and lymphoma. This does not imply that Ciprofloxacin treats lymphoma; rather, it suggests that Ciprofloxacin may help prevent infections in immunocompromised lymphoma patients during transplantation procedures. The distinction is crucial as treatment refers to combatting the disease itself while prophylaxis indicates prevention of complications (in this case infections) associated with the disease or treatment thereof." +19067853,Ciprofloxacin treats B-cell chronic lymphocytic leukemia,1334,A case of septic arthritis caused by a Mycoplasma salivarium strain resistant towards Ciprofloxacin and Clarithromycin in a patient with chronic lymphatic leukemia.,False,"'Does the phrase ""Ciprofloxacin treats B-cell chronic lymphocytic leukemia"" receive at least indirect support from the statement: ""A case of septic arthritis caused by a Mycoplasma salivarium strain resistant towards Ciprofloxacin and Clarithromycin in a patient with chronic lymphatic leukemia.""?","No, the statement does not provide indirect support for the claim that ""Ciprofloxacin treats B-cell chronic lymphocytic leukemia."" The statement discusses a case of septic arthritis in a patient with chronic lymphatic leukemia (B-cell chronic lymphocytic leukemia is a type of chronic lymphatic leukemia) caused by a Mycoplasma salivarium strain resistant to Ciprofloxacin and Clarithromycin. This implies that Ciprofloxacin was ineffective against the Mycoplasma salivarium strain in this case, not that it has therapeutic effects on B-cell chronic lymphocytic leukemia." +14572951,Ciprofloxacin treats hearing loss disorder,1335,Treatment with ciprofloxacin and ceftazidime improved the hearing loss significantly.,False,"'Does the phrase ""Ciprofloxacin treats hearing loss disorder"" receive at least indirect support from the statement: ""Treatment with ciprofloxacin and ceftazidime improved the hearing loss significantly.""?","No, the phrase ""Ciprofloxacin treats hearing loss disorder"" does not receive direct support from the statement ""Treatment with ciprofloxacin and ceftazidime improved the hearing loss significantly."" - In summary, while the statement does not explicitly prove that methylprednisolone treats COPD on its own, it does provide evidence that methylprednisolone may be beneficial as an adjunct therapy for managing specific COPD symptoms in certain patient populations. Further research is needed to fully establish its therapeutic potential for COPD treatment." -13533673,Methylprednisolone treats macrophage activation syndrome,1266,"Following treatment with etanercept, ibuprofen, methylprednisolone, and phenylbutazone for 3 weeks, MAS deteriorated and fatal cerebral edema occurred within only 24 h.",False,"Is the triple 'Methylprednisolone treats macrophage activation syndrome' supported by the sentence: 'Following treatment with etanercept, ibuprofen, methylprednisolone, and phenylbutazone for 3 weeks, MAS deteriorated and fatal cerebral edema occurred within only 24 h.'?","No, the statement does not provide indirect support for the claim that ""Methylprednisolone treats macrophage activation syndrome (MAS)"". In fact, it seems to suggest the opposite: despite treatment including methylprednisolone among other medications, MAS deteriorated rapidly within 24 hours leading to fatal cerebral edema. This implies that methylprednisolone was either ineffective in treating MAS in this particular case or that additional factors contributed to the poor outcome. Nonetheless, it is important to note that a single case study does not establish definitive evidence for or against therapeutic efficacy; controlled clinical trials would be required for that purpose." -13161419,Methylprednisolone treats systemic sclerosis,1267,"CONCLUSION: The results of this pilot study suggest that the combination of MMF, IV MP and low-dose GC might achieve good clinical, functional and radiological results in patients suffering from severe early SSc.",True,"Is the triple 'Methylprednisolone treats systemic sclerosis' supported by the sentence: 'CONCLUSION: The results of this pilot study suggest that the combination of MMF, IV MP and low-dose GC might achieve good clinical, functional and radiological results in patients suffering from severe early SSc.'?","Yes, indirect support can be inferred from the statement provided. The conclusion states that a combination therapy including intravenous Methylprednisolone (IV MP) has shown promising results in treating severe early Systemic Sclerosis (SSc). However, it is important to note that the statement does not explicitly claim that Methylprednisolone alone treats SSc; rather it supports the efficacy of the combined treatment regimen that includes Methylprednisolone. + The statement provides evidence that a combination of ciprofloxacin and ceftazidime has been successful in treating hearing loss in a specific context, but it does not necessarily indicate that ciprofloxacin alone is responsible for treating hearing loss disorders. It is possible that both drugs contribute equally to improving hearing loss, that ceftazidime is the more significant factor, or that another unmentioned factor is responsible for the improvement in hearing loss symptoms. - + To establish whether ciprofloxacin treats hearing loss disorder specifically would require further evidence isolating ciprofloxacin as an active ingredient in treating hearing loss disorders in controlled studies where confounding factors have been accounted for and minimized." +14398199,Ciprofloxacin treats sinusitis,1336,"CASE SUMMARY: A 24-year-old woman was admitted to the hospital because of convulsions, severe myopathy, and acute renal failure after taking ciprofloxacin for sinusitis, and urinary tract infections.",False,"'Does the phrase ""Ciprofloxacin treats sinusitis"" receive at least indirect support from the statement: ""CASE SUMMARY: A 24-year-old woman was admitted to the hospital because of convulsions, severe myopathy, and acute renal failure after taking ciprofloxacin for sinusitis, and urinary tract infections.""?","No, the statement does not provide indirect support for the claim that ""Ciprofloxacin treats sinusitis."" In fact, it suggests quite the opposite. The case summary describes adverse effects experienced by a patient who took Ciprofloxacin for sinusitis and urinary tract infections. This indicates that while Ciprofloxacin may be used to treat these conditions, it can also have serious side effects. The statement does not provide any evidence that Ciprofloxacin was effective in treating sinusitis in this case; on the contrary, it suggests that the patient suffered significant harm as a result of taking the drug. Therefore, it does not support the claim that Ciprofloxacin treats sinusitis." +14311974,Ciprofloxacin treats liver abscess (disease),1337,Chromobacterium violaceum endocarditis and hepatic abscesses treated successfully with meropenem and ciprofloxacin.,True,"'Does the phrase ""Ciprofloxacin treats liver abscess (disease)"" receive at least indirect support from the statement: ""Chromobacterium violaceum endocarditis and hepatic abscesses treated successfully with meropenem and ciprofloxacin.""?","Yes, indirectly it does lend some support. The statement mentions that Ciprofloxacin was used in conjunction with Meropenem to successfully treat endocarditis (inflammation of the heart valve) and hepatic abscesses (liver abscesses) caused by Chromobacterium violaceum. This suggests that Ciprofloxacin could potentially be effective in treating liver abscesses, although it's important to note that it was used as part of a combination therapy in this case. However, it's crucial to remember that each case is unique and treatment should be individualized based on the patient's specific condition, allergies, potential drug interactions, and other factors. Therefore, while this evidence suggests a potential benefit, it does not conclusively prove that Ciprofloxacin alone is an effective treatment for liver abscesses." +14284683,Ciprofloxacin treats gastroenteritis,1338,"A patient is reported who had previously maintained a stable prothrombin time on Coumadin for 5 years, and who exhibited a marked prolongation of prothrombin time when placed on ciprofloxacin for gastroenteritis.",False,"'Does the phrase ""Ciprofloxacin treats gastroenteritis"" receive at least indirect support from the statement: ""A patient is reported who had previously maintained a stable prothrombin time on Coumadin for 5 years, and who exhibited a marked prolongation of prothrombin time when placed on ciprofloxacin for gastroenteritis.""?","No, the statement does not provide indirect support for the phrase ""Ciprofloxacin treats gastroenteritis."" The statement describes an adverse effect of Ciprofloxacin on prothrombin time in a patient being treated for gastroenteritis, but it does not imply that Ciprofloxacin is an effective treatment for gastroenteritis. - The statement comes from a pilot study which typically has smaller sample sizes and less statistical power compared to larger-scale clinical trials; thus its conclusions should be interpreted with caution. Ideally, further research should be conducted to specifically evaluate the effectiveness of Methylprednisolone as a standalone treatment for systemic sclerosis in order to establish stronger support for such a claim." -13096165,Methylprednisolone treats optic nerve disorder,1268,"Dysthyroid optic neuropathy is best treated with intravenous pulsed methylprednisolone; if visual functions do not recover, urgent surgical decompression is indicated.",True,"Is the triple 'Methylprednisolone treats optic nerve disorder' supported by the sentence: 'Dysthyroid optic neuropathy is best treated with intravenous pulsed methylprednisolone; if visual functions do not recover, urgent surgical decompression is indicated.'?","Yes, the statement does provide indirect support for the phrase ""Methylprednisolone treats optic nerve disorder"". The statement suggests that dysthyroid optic neuropathy, which is an optic nerve disorder, is best treated with intravenous pulsed methylprednisolone. This implies that methylprednisolone is an effective treatment for at least one type of optic nerve disorder. However, it's important to note that this does not necessarily mean that methylprednisolone is effective for all types of optic nerve disorders. The effectiveness of methylprednisolone for other types of optic nerve disorders would need to be evaluated separately based on available evidence." -12975348,Methylprednisolone treats mature T-cell and NK-cell non-Hodgkin lymphoma,1269,"Gemcitabine, cisplatin and methylprednisolone for the treatment of patients with peripheral T-cell lymphoma: the Royal Marsden Hospital experience.",False,"Is the triple 'Methylprednisolone treats mature T-cell and NK-cell non-Hodgkin lymphoma' supported by the sentence: 'Gemcitabine, cisplatin and methylprednisolone for the treatment of patients with peripheral T-cell lymphoma: the Royal Marsden Hospital experience.'?","No, the statement does not provide direct support for the claim that ""Methylprednisolone treats mature T-cell and NK-cell non-Hodgkin lymphoma"". The article cited discusses a treatment regimen that includes methylprednisolone, gemcitabine, and cisplatin for peripheral T-cell lymphoma. However, it does not explicitly state that methylprednisolone is responsible for treating mature T-cell and NK-cell non-Hodgkin lymphoma specifically. + The statement focuses on the patient's response to Ciprofloxacin therapy in terms of prothrombin time alterations while on Coumadin, which is an anticoagulant drug unrelated to gastroenteritis treatment. The potential side effects of Ciprofloxacin, including its influence on prothrombin time in patients taking Coumadin, have been documented in previous studies (e.g., Weisbord SD et al., 2011). However, there is no evidence in the statement suggesting that Ciprofloxacin has any therapeutic effect on gastroenteritis. - - To further explain, in clinical settings, drugs like methylprednisolone often form part of combination therapies due to their immunosuppressive properties. While such drugs may contribute to positive patient outcomes in certain treatment regimens, attributing their impact solely on specific subtypes of non-Hodgkin lymphoma without further investigation would be an oversimplification of the complex interplay between various treatment components and individual patient characteristics within these heterogeneous diseases. + In fact, gastroenteritis is typically treated through supportive care (e.g., hydration) and antibiotics only" +14141218,Ciprofloxacin treats castration-resistant prostate carcinoma,1339,"Doxorubicin and docetaxel, two standard antineoplastic agents in hormone-refractory prostate cancer (HRPC) therapy and ciprofloxacin were evaluated singly and in several simultaneous and sequential drug combination schemes, against PC-3 and LNCaP cell lines.",False,"'Does the phrase ""Ciprofloxacin treats castration-resistant prostate carcinoma"" receive at least indirect support from the statement: ""Doxorubicin and docetaxel, two standard antineoplastic agents in hormone-refractory prostate cancer (HRPC) therapy and ciprofloxacin were evaluated singly and in several simultaneous and sequential drug combination schemes, against PC-3 and LNCaP cell lines.""?","No, the statement does not provide direct or indirect support for the claim that ""Ciprofloxacin treats castration-resistant prostate carcinoma."" The statement only mentions that ciprofloxacin was evaluated along with other drugs against PC-3 and LNCaP cell lines, which are common models used in prostate cancer research. However, it does not provide any information about the results of these experiments, whether ciprofloxacin had any effect on prostate cancer cells, or if it has been used in any clinical setting for treating castration-resistant prostate carcinoma. Therefore, it is not possible to make any conclusions about the effectiveness of ciprofloxacin for treating castration-resistant prostate carcinoma based on this statement alone." +14005051,Ciprofloxacin treats acute myeloid leukemia,1340,"Results of combination therapy with amifostine, pentoxifylline, ciprofloxacin and dexamethasone in patients with myelodysplastic syndrome and acute myeloid leukemia.",False,"'Does the phrase ""Ciprofloxacin treats acute myeloid leukemia"" receive at least indirect support from the statement: ""Results of combination therapy with amifostine, pentoxifylline, ciprofloxacin and dexamethasone in patients with myelodysplastic syndrome and acute myeloid leukemia.""?","No, the phrase ""Ciprofloxacin treats acute myeloid leukemia"" does not receive indirect support from the statement provided. The statement mentions that ciprofloxacin is used in combination therapy for myelodysplastic syndrome and acute myeloid leukemia patients, but it does not specify that ciprofloxacin treats acute myeloid leukemia on its own. In fact, it suggests that ciprofloxacin is used in combination with other drugs (amifostine, pentoxifylline, and dexamethasone), which implies that its effect may be dependent on these other treatments. Therefore, we cannot infer from this statement that ciprofloxacin is an effective treatment for acute myeloid leukemia when used alone." +13846017,Ciprofloxacin treats lung disorder,1341,High dose parenteral ciprofloxacin in pleuro-pulmonary disease: a comparative pharmacolinetics of 400 and 200 mg intravenous.,False,"'Does the phrase ""Ciprofloxacin treats lung disorder"" receive at least indirect support from the statement: ""High dose parenteral ciprofloxacin in pleuro-pulmonary disease: a comparative pharmacolinetics of 400 and 200 mg intravenous.""?","No, the statement ""High dose parenteral ciprofloxacin in pleuro-pulmonary disease: a comparative pharmacokinetics of 400 and 200 mg intravenous."" does not provide indirect support for the phrase ""Ciprofloxacin treats lung disorder."" - - In conclusion, while methylprednisolone may be used in treating mature T-cell and NK-cell non-" -12450216,Methylprednisolone treats bronchopulmonary dysplasia,1270,Hypertrophic cardiomyopathy in preterm infants treated with methylprednisolone for bronchopulmonary dysplasia.,True,Is the triple 'Methylprednisolone treats bronchopulmonary dysplasia' supported by the sentence: 'Hypertrophic cardiomyopathy in preterm infants treated with methylprednisolone for bronchopulmonary dysplasia.'?,"Yes, the statement does provide indirect support for the claim that methylprednisolone treats bronchopulmonary dysplasia (BPD). The reason is that methylprednisolone is being used as a treatment for hypertrophic cardiomyopathy in preterm infants who have BPD. This implies that methylprednisolone is being administered in the context of BPD management, suggesting that it may have some therapeutic effect on BPD itself, even if that is not the primary condition being treated. + The statement in question is a comparative pharmacokinetics study on ciprofloxacin in pleuro-pulmonary disease, focusing on different dosages administered intravenously. While it does discuss ciprofloxacin's use in lung-related diseases (pleuro-pulmonary), it does not provide evidence that ciprofloxacin treats these disorders. The study is concerned with how ciprofloxacin is absorbed, distributed, metabolized, and excreted in the body at different dosages, not its therapeutic effects on lung disorders. Therefore, it does not offer support for the claim that ciprofloxacin treats lung disorders." +13663890,Ciprofloxacin treats otitis media,1342,[Pneumococcal meningitis during ciprofloxacin therapy for otitis media].,False,"'Does the phrase ""Ciprofloxacin treats otitis media"" receive at least indirect support from the statement: ""[Pneumococcal meningitis during ciprofloxacin therapy for otitis media].""?","No, the statement ""Pneumococcal meningitis during ciprofloxacin therapy for otitis media"" does not provide indirect support for the claim ""Ciprofloxacin treats otitis media."" The statement actually suggests that ciprofloxacin may not be effective in treating otitis media caused by pneumococcal bacteria, as evidenced by the development of pneumococcal meningitis despite ciprofloxacin treatment for otitis media. - + Ciprofloxacin is an antibiotic in the fluoroquinolone class that is not typically used as a first-line treatment for otitis media due to its potential adverse effects on children’s developing musculoskeletal systems. Moreover, certain strains of bacteria causing otitis media may be resistant to ciprofloxacin, necessitating alternative antibiotics for effective treatment. - However, it is important to note that this does not constitute direct evidence for the effectiveness of methylprednisolone in treating BPD. To establish that, we would need clinical trials or other rigorous studies specifically designed to evaluate the impact of methylprednisolone on BPD outcomes. The current statement indicates an association between methylprednisolone use and BPD management but does not prove causation." -11895116,Methylprednisolone treats plasma cell myeloma,1271,Multiple myeloma of Stage IIa was diagnosed and she was given cytostatic therapy with 17.5 mg melphalan and 112 mg methylprednisolone daily by mouth (for 4 days at intervals of 6 weeks).,True,Is the triple 'Methylprednisolone treats plasma cell myeloma' supported by the sentence: 'Multiple myeloma of Stage IIa was diagnosed and she was given cytostatic therapy with 17.5 mg melphalan and 112 mg methylprednisolone daily by mouth (for 4 days at intervals of 6 weeks).'?,"Yes, the statement does provide indirect support for the phrase ""Methylprednisolone treats plasma cell myeloma."" The patient in question was diagnosed with multiple myeloma (a type of plasma cell myeloma) and was administered methylprednisolone as part of her cytostatic therapy. This suggests that methylprednisolone is used in treating plasma cell myeloma, at least in combination with other drugs like melphalan. However, it is important to note that correlation does not imply causation, so while methylprednisolone is used in treating plasma cell myeloma, it does not necessarily mean it is solely responsible for treating it." -11882768,Methylprednisolone treats Cognitive impairment,1272,One-year cyclophosphamide treatment combined with methylprednisolone improves cognitive dysfunction in progressive forms of multiple sclerosis.,True,Is the triple 'Methylprednisolone treats Cognitive impairment' supported by the sentence: 'One-year cyclophosphamide treatment combined with methylprednisolone improves cognitive dysfunction in progressive forms of multiple sclerosis.'?,"Yes, there is indirect support for the statement that ""Methylprednisolone treats cognitive impairment"" in light of the provided evidence: ""One-year cyclophosphamide treatment combined with methylprednisolone improves cognitive dysfunction in progressive forms of multiple sclerosis."" + The development of pneumococcal meningitis during ciprofloxacin therapy for otitis media implies that ciprofloxacin is unable to eliminate pneumococcal bacteria causing ot" +11840711,Ciprofloxacin treats cataract,1343,"CONCLUSIONS: Ofloxacin has higher corneal penetration and ability to exceed MIC90 of common ocular contaminants than ciprofloxacin, and would be a more appropriate prophylactic choice for canine cataract patients.",False,"'Does the phrase ""Ciprofloxacin treats cataract"" receive at least indirect support from the statement: ""CONCLUSIONS: Ofloxacin has higher corneal penetration and ability to exceed MIC90 of common ocular contaminants than ciprofloxacin, and would be a more appropriate prophylactic choice for canine cataract patients.""?","No, the statement does not provide indirect support for the phrase ""Ciprofloxacin treats cataract."" The conclusion is comparing two antibiotics, Ofloxacin and Ciprofloxacin, in terms of their corneal penetration and ability to exceed MIC90 of common ocular contaminants in canine cataract patients. It suggests Ofloxacin as a more appropriate prophylactic choice due to its superior properties in these aspects. However, it does not provide any information linking Ciprofloxacin to treating cataract. Cataract treatment typically involves surgical removal of the opaque lens and replacement with an artificial one, not antibiotics like Ciprofloxacin." +11684450,Ciprofloxacin treats cystitis,1344,Amoxicillin-clavulanate vs ciprofloxacin for the treatment of uncomplicated cystitis in women: a randomized trial.,True,"'Does the phrase ""Ciprofloxacin treats cystitis"" receive at least indirect support from the statement: ""Amoxicillin-clavulanate vs ciprofloxacin for the treatment of uncomplicated cystitis in women: a randomized trial.""?","Yes, the phrase ""Ciprofloxacin treats cystitis"" does receive indirect support from the statement ""Amoxicillin-clavulanate vs ciprofloxacin for the treatment of uncomplicated cystitis in women: a randomized trial."" This is because the study compares two treatments for cystitis (Amoxicillin-clavulanate and Ciprofloxacin), implying that both have been considered as potential treatments for cystitis by the researchers conducting the study. The fact that Ciprofloxacin is included in such a study suggests that it is recognized as having potential efficacy in treating cystitis, even if it is not explicitly stated in the title of the study. - - The rationale behind this conclusion lies in recognizing that methylprednisolone is an essential component in an intervention shown to improve cognitive dysfunction in multiple sclerosis patients. This suggests that methylprednisolone has some therapeutic effect in addressing cognitive impairment in that specific context. + However, it is important to note that indirect support does not equate to definitive proof of efficacy. The study may have found that Ciprofloxacin was less effective than Amoxicillin-clavulanate in treating cystitis in women, for example. Therefore, further investigation into the specific results of the study would be necessary for a more complete understanding of Cip" +11679354,Ciprofloxacin treats Pseudomonas infection,1345,We used a simple Wood's light examination and culture to establish the diagnosis of Pseudomonas toe web infection and achieved rapid resolution with oral ciprofloxacin treatment and local application of Castellani's paint.,True,"'Does the phrase ""Ciprofloxacin treats Pseudomonas infection"" receive at least indirect support from the statement: ""We used a simple Wood's light examination and culture to establish the diagnosis of Pseudomonas toe web infection and achieved rapid resolution with oral ciprofloxacin treatment and local application of Castellani's paint.""?","Yes, the statement does provide indirect support for the claim that ""Ciprofloxacin treats Pseudomonas infection"". The user's statement describes a case where a patient was diagnosed with a Pseudomonas toe web infection, which was then treated with oral Ciprofloxacin and Castellani's paint. The fact that they mention ""rapid resolution"" suggests that the treatment was effective, thereby implying that Ciprofloxacin is an effective treatment for Pseudomonas infections. - - However, it is essential to acknowledge that this evidence does not provide direct proof that methylprednisolone is solely responsible for treating cognitive impairment in multiple sclerosis patients. The intervention also includes cyclophosphamide treatment, which may contribute synergistically to cognitive improvement in these patients. + However, it is important to note that while this does provide some level of support for the claim, it is not direct evidence because it is based on a single case study rather than a controlled clinical trial or other rigorous study design. Additionally, while Ciprofloxacin is an antibiotic commonly used to treat Pseudomonas infections due to its broad-spectrum activity against gram-negative bacteria like Pseudomonas aeruginosa, it is not always effective in all cases due to factors such as antibiotic resistance. Therefore, while the statement supports the claim that Ciprofloxacin can be used to" +11628762,Ciprofloxacin treats endophthalmitis,1346,Ciprofloxacin in endophthalmitis: an alternative to ceftazidime and amikacin!,True,"'Does the phrase ""Ciprofloxacin treats endophthalmitis"" receive at least indirect support from the statement: ""Ciprofloxacin in endophthalmitis: an alternative to ceftazidime and amikacin!""?","Yes, the phrase ""Ciprofloxacin treats endophthalmitis"" does receive indirect support from the statement ""Ciprofloxacin in endophthalmitis: an alternative to ceftazidime and amikacin!"" - - Therefore, while there is indirect support for methylprednisolone having some positive impact on cognitive impairment based on this statement, further investigation would be required for more definitive conclusions regarding its isolated efficacy in treating cognitive imp" -11547088,Methylprednisolone treats thrombotic thrombocytopenic purpura,1273,"The hematologic evaluations and her clinical course revealed the diagnosis of TTP, so plasma exchange and methyl-prednisolone therapy were initiated.",True,"Is the triple 'Methylprednisolone treats thrombotic thrombocytopenic purpura' supported by the sentence: 'The hematologic evaluations and her clinical course revealed the diagnosis of TTP, so plasma exchange and methyl-prednisolone therapy were initiated.'?","Yes, the statement does provide indirect support for the claim that methylprednisolone treats thrombotic thrombocytopenic purpura (TTP). The statement indicates that after diagnosing TTP in a patient through hematologic evaluations and clinical course assessment, plasma exchange and methylprednisolone therapy were initiated. This implies that methylprednisolone was used as part of the treatment regimen for TTP, thus offering support for its use in managing TTP even if not explicitly stating that it treats TTP. However, it should be noted that direct causality cannot be inferred from this statement alone; more rigorous clinical studies would be required for definitive evidence regarding its therapeutic effect on TTP." -11313619,Methylprednisolone treats vestibular neuronitis,1274,"METHODS: We performed a prospective, randomized, double-blind, two-by-two factorial trial in which patients with acute vestibular neuritis were randomly assigned to treatment with placebo, methylprednisolone, valacyclovir, or methylprednisolone plus valacyclovir.",True,"Is the triple 'Methylprednisolone treats vestibular neuronitis' supported by the sentence: 'METHODS: We performed a prospective, randomized, double-blind, two-by-two factorial trial in which patients with acute vestibular neuritis were randomly assigned to treatment with placebo, methylprednisolone, valacyclovir, or methylprednisolone plus valacyclovir.'?","Yes, the statement does provide indirect support for the claim that methylprednisolone treats vestibular neuronitis. The methodology described in the statement includes a clinical trial where patients diagnosed with acute vestibular neuritis were randomly assigned to receive treatment with methylprednisolone (either alone or in combination with valacyclovir). The fact that methylprednisolone was selected as a treatment group in a prospective, randomized, double-blind trial suggests that there is some basis for believing that it may have therapeutic benefits for treating vestibular neuronitis. + The title of the study suggests that ciprofloxacin is being considered as an alternative treatment for endophthalmitis, which is an inflammation of the interior of the eye. This implies that ciprofloxacin has some efficacy in treating endophthalmitis, even though it may not be the first-line treatment. The fact that it is presented as an alternative to other established treatments (ceftazidime and amikacin) further supports this interpretation. However, it is important to note that this support is indirect and based on the title alone; the full study would need to be evaluated for a more definitive conclusion." +11564697,Ciprofloxacin treats chronic obstructive pulmonary disease,1347,Reported here is the case of a patient with underlying chronic obstructive pulmonary disease (COPD) in whom ciprofloxacin treatment of a lower respiratory tract infection failed subsequent to ciprofloxacin treatment of an exacerbation of COPD several weeks earlier.,False,"'Does the phrase ""Ciprofloxacin treats chronic obstructive pulmonary disease"" receive at least indirect support from the statement: ""Reported here is the case of a patient with underlying chronic obstructive pulmonary disease (COPD) in whom ciprofloxacin treatment of a lower respiratory tract infection failed subsequent to ciprofloxacin treatment of an exacerbation of COPD several weeks earlier.""?","No, the statement does not provide indirect support for the claim that ""Ciprofloxacin treats chronic obstructive pulmonary disease (COPD)"". In fact, it suggests quite the opposite. The statement indicates that a patient with COPD was treated with ciprofloxacin for two separate conditions - a lower respiratory tract infection and an exacerbation of COPD - and that the treatment failed for the later condition. This implies that ciprofloxacin may not be effective in treating COPD exacerbations. However, it is important to note that this is based on a single case report and further studies would be needed to make definitive conclusions about the effectiveness of ciprofloxacin in treating COPD." +11304087,Ciprofloxacin treats eye infectious disorder,1348,This PK-MB model may be very useful in optimizing treatments of various eye infections with ciprofloxacin.,True,"'Does the phrase ""Ciprofloxacin treats eye infectious disorder"" receive at least indirect support from the statement: ""This PK-MB model may be very useful in optimizing treatments of various eye infections with ciprofloxacin.""?","Yes, indirectly it does lend support. The statement ""This PK-MB model may be very useful in optimizing treatments of various eye infections with ciprofloxacin"" suggests that there is an existing model (PK-MB) that can help improve the use of Ciprofloxacin in treating different eye infections. This implies that Ciprofloxacin is indeed used for treating eye infections, thus providing indirect support for the claim ""Ciprofloxacin treats eye infectious disorder"". However, it's important to note that the original statement does not provide direct evidence of Ciprofloxacin's effectiveness in treating eye infections, but rather suggests that the model could help optimize its use in treatment." +11059709,Ciprofloxacin treats abscess,1349,"The patient was asymptomatic for a month, but the abscess reactivated and was treated with Vancomycin and Ciprofloxacin administered intravenously.",True,"'Does the phrase ""Ciprofloxacin treats abscess"" receive at least indirect support from the statement: ""The patient was asymptomatic for a month, but the abscess reactivated and was treated with Vancomycin and Ciprofloxacin administered intravenously.""?","Yes, the statement does provide indirect support for the phrase ""Ciprofloxacin treats abscess"". The patient was initially asymptomatic for a month, indicating that the abscess had been under control prior to its reactivation. The fact that Ciprofloxacin was used in treating the reactivated abscess suggests that it was considered effective against the infection causing the abscess. However, it is important to note that Ciprofloxacin was administered in conjunction with Vancomycin in this case, which may imply that Ciprofloxacin alone might not be sufficient for treating an abscess in all cases. - However, it is important to note that while this methodology supports methylprednisolone as a potential treatment for vestibular neuronitis, it does not definitively prove that methylprednisolone treats vestibular neuronitis. The trial would need to be evaluated for factors such as sample size, statistical significance, effect size, potential confounding factors, and adherence to best practices in clinical trial design and analysis before drawing any definitive conclusions about its efficacy as a treatment for vestibular neuronitis." -10801960,Methylprednisolone treats B-cell chronic lymphocytic leukemia,1275,High dose methylprednisolone can induce remissions in CLL patients with p53 abnormalities.,False,Is the triple 'Methylprednisolone treats B-cell chronic lymphocytic leukemia' supported by the sentence: 'High dose methylprednisolone can induce remissions in CLL patients with p53 abnormalities.'?,"No, the statement ""High dose methylprednisolone can induce remissions in CLL patients with p53 abnormalities"" does not provide direct support for the claim that ""Methylprednisolone treats B-cell chronic lymphocytic leukemia"" (CLL). The original statement refers specifically to CLL patients with p53 abnormalities, which is not equivalent to making a general claim about treating all B-cell chronic lymphocytic leukemia cases. + To further substantiate the claim that Ciprofloxacin can treat abscesses, additional evidence such as clinical trials demonstrating its efficacy in treating abscesses would be needed. It is also important to consider potential factors that may influence Ciprofloxacin's effectiveness against abscesses, such as antibiotic resistance, severity of infection, location of abscess, and patient-specific factors like immune status. - However, it is important to note that indirect support might be inferred if there is evidence suggesting that p53 abnormalities play a significant role in CLL progression, making it reasonable that methylprednisolone could potentially be used as a treatment for CLL in general. Nevertheless, without further information linking p53 abnormalities and CLL progression as well as methylprednisolone's effect on CLL without p53 abnormalities, it is not possible to establish direct support for the original claim based on the provided statement alone. + In summary," +10087799,Ciprofloxacin treats bacterial infectious disease,1350,"Fluoroquinolones such as ciprofloxacin, levofloxacin, moxifloxacin and gatifloxacin are widely used for the treatment of bacterial infections.",True,"'Does the phrase ""Ciprofloxacin treats bacterial infectious disease"" receive at least indirect support from the statement: ""Fluoroquinolones such as ciprofloxacin, levofloxacin, moxifloxacin and gatifloxacin are widely used for the treatment of bacterial infections.""?","Yes, the statement ""Fluoroquinolones such as ciprofloxacin, levofloxacin, moxifloxacin and gatifloxacin are widely used for the treatment of bacterial infections"" does provide indirect support for the claim that ""Ciprofloxacin treats bacterial infectious disease"". This is because ciprofloxacin is listed as one of the fluoroquinolones that are used for treating bacterial infections. However, it is important to note that while this suggests that ciprofloxacin is effective against bacterial infections, it does not constitute direct evidence of its efficacy. It would be more conclusive if there were a specific study demonstrating ciprofloxacin's effectiveness against bacterial infections. Nonetheless, given the general understanding in medical science that fluoroquinolones are used for treating bacterial infections, it is reasonable to infer that ciprofloxacin would also be effective for this purpose." +10013051,Ciprofloxacin treats plague,1351,There are no previous reports of plague being successfully treated with ciprofloxacin.,False,"'Does the phrase ""Ciprofloxacin treats plague"" receive at least indirect support from the statement: ""There are no previous reports of plague being successfully treated with ciprofloxacin.""?","No, the statement ""There are no previous reports of plague being successfully treated with ciprofloxacin"" does not provide indirect support for the claim that ""Ciprofloxacin treats plague"". In fact, it suggests the opposite. The absence of previous successful treatments implies that ciprofloxacin has not been proven effective against plague. Therefore, more evidence would be needed to support the claim that ciprofloxacin is an effective treatment for plague." +10002223,Ciprofloxacin treats anthrax infection,1352,Treatment and post-exposure prophylaxis for anthrax are ciprofloxacin or doxycycline.,True,"'Does the phrase ""Ciprofloxacin treats anthrax infection"" receive at least indirect support from the statement: ""Treatment and post-exposure prophylaxis for anthrax are ciprofloxacin or doxycycline.""?","Yes, the phrase ""Ciprofloxacin treats anthrax infection"" does receive indirect support from the statement ""Treatment and post-exposure prophylaxis for anthrax are ciprofloxacin or doxycycline."" This is because ciprofloxacin is listed as an option for treatment and post-exposure prophylaxis of anthrax infections. However, it is important to note that while ciprofloxacin can be used to treat anthrax infections, it is not always the first-line treatment and its use should be determined by a healthcare professional based on various factors such as patient history, potential side effects, and resistance patterns." +9704134,Ciprofloxacin treats bronchiectasis,1353,"He had severe airway obstruction and focal bronchiectasis, and responded to treatment with ciprofloxacin and clarithromycin.",True,"'Does the phrase ""Ciprofloxacin treats bronchiectasis"" receive at least indirect support from the statement: ""He had severe airway obstruction and focal bronchiectasis, and responded to treatment with ciprofloxacin and clarithromycin.""?","Yes, indirectly it does lend some support. The statement suggests that the individual had bronchiectasis along with severe airway obstruction, and they responded positively to treatment involving ciprofloxacin (a type of antibiotic often used for treating infections caused by bacteria) in combination with clarithromycin (another antibiotic). However, it is important to note that bronchiectasis can be caused by various factors including bacterial infections, fungal infections, autoimmune diseases etc., so attributing improvement solely to ciprofloxacin might not be entirely accurate without further information about what specifically caused the bronchiectasis in this case." +9552171,Ciprofloxacin treats otitis externa,1354,"The objective of this study was to evaluate and compare the efficacy of topical otic powder, tobramycin drops and ciprofloxacin drops in patients suffering from AEO.",True,"'Does the phrase ""Ciprofloxacin treats otitis externa"" receive at least indirect support from the statement: ""The objective of this study was to evaluate and compare the efficacy of topical otic powder, tobramycin drops and ciprofloxacin drops in patients suffering from AEO.""?","Yes, the statement ""Ciprofloxacin treats otitis externa"" does receive indirect support from the provided statement. The study mentioned in the statement is focused on assessing and comparing the efficacy of different treatments for Acute Otitis Externa (AEO), one of which is Ciprofloxacin drops. The fact that Ciprofloxacin is being studied in relation to otitis externa implies that it is being considered as a potential treatment for this condition. Therefore, it can be inferred that Ciprofloxacin has some level of association with treating otitis externa based on this indirect evidence. However, it is important to note that further investigation into the results of the study is needed for a more definitive conclusion about Ciprofloxacin's effectiveness in treating otitis externa." +9504629,Ciprofloxacin treats Sepsis,1355,Ciprofloxacin pharmacokinetic profiles in paediatric sepsis: how much ciprofloxacin is enough?,False,"'Does the phrase ""Ciprofloxacin treats Sepsis"" receive at least indirect support from the statement: ""Ciprofloxacin pharmacokinetic profiles in paediatric sepsis: how much ciprofloxacin is enough?""?","No, the statement ""Ciprofloxacin treats Sepsis"" does not receive at least indirect support from the title ""Ciprofloxacin pharmacokinetic profiles in paediatric sepsis: how much ciprofloxacin is enough?"" - In conclusion, while it is plausible that methylprednisolone might be useful" -10634179,Methylprednisolone treats Crohn disease,1276,An example of acute pancreatitis developing five weeks after initial treatment with 5-aminosalicylic acid (5-ASA) and methylprednisolone for severe Crohn's disease is reported in a 37 year old female patient.,False,Is the triple 'Methylprednisolone treats Crohn disease' supported by the sentence: 'An example of acute pancreatitis developing five weeks after initial treatment with 5-aminosalicylic acid (5-ASA) and methylprednisolone for severe Crohn's disease is reported in a 37 year old female patient.'?,"No, the statement does not provide direct or indirect support for the claim that ""Methylprednisolone treats Crohn disease"". The statement reports an adverse event (acute pancreatitis) in a patient being treated for Crohn's disease with methylprednisolone and 5-ASA. It does not provide any information about the therapeutic effect of methylprednisolone on Crohn disease. In fact, it could be argued that it suggests a potential side effect or complication associated with methylprednisolone use in Crohn disease patients. Therefore, it does not support the claim that methylprednisolone is an effective treatment for Crohn disease." -10341065,Methylprednisolone treats severe acute respiratory syndrome,1277,Twenty-nine of the 30 SARS patients were treated by methylprednisolone.,True,Is the triple 'Methylprednisolone treats severe acute respiratory syndrome' supported by the sentence: 'Twenty-nine of the 30 SARS patients were treated by methylprednisolone.'?,"Yes, the statement does provide indirect support for the claim that methylprednisolone treats severe acute respiratory syndrome (SARS). The fact that 29 out of 30 SARS patients were treated with methylprednisolone suggests that there is a potential association between methylprednisolone use and improved outcomes in SARS patients. However, it is important to note that correlation does not imply causation. The statement does not provide direct evidence that methylprednisolone is an effective treatment for SARS; it merely indicates an observed association that warrants further investigation. + While it is true that the title mentions Ciprofloxacin and Sepsis, it does not provide evidence that Ciprofloxacin is an effective treatment for Sepsis. The title is focused on pharmacokinetic profiles, which refers to how a drug moves through the body, including absorption, distribution, metabolism, and excretion. It does not provide information about the drug's efficacy in treating Sepsis. Therefore, it does not provide indirect support for the claim that Ciprofloxacin treats Sepsis." +9281470,Ciprofloxacin treats prostatitis,1356,The emergence and evolution of quinolone-resistant Escherichia coli in faeces of patients with prostatitis treated with high-dose oral ciprofloxacin for 1 month were studied.,False,"'Does the phrase ""Ciprofloxacin treats prostatitis"" receive at least indirect support from the statement: ""The emergence and evolution of quinolone-resistant Escherichia coli in faeces of patients with prostatitis treated with high-dose oral ciprofloxacin for 1 month were studied.""?","No, the statement does not provide indirect support for the phrase ""Ciprofloxacin treats prostatitis."" The study focuses on the emergence and evolution of quinolone-resistant Escherichia coli in faeces of patients with prostatitis treated with high-dose oral ciprofloxacin for 1 month. While it is true that ciprofloxacin is being used as a treatment in this context, the statement does not provide information about the effectiveness of ciprofloxacin in treating prostatitis, which is what the phrase ""Ciprofloxacin treats prostatitis"" implies." +8956827,Ciprofloxacin treats Abdominal Infection,1357,"Ciprofloxacin is effective in the treatment of serious, non-self-limiting intra-abdominal infections, peritonitis in CAPD, pelvic inflammatory disease, endometritis and gall-bladder infections.",True,"'Does the phrase ""Ciprofloxacin treats Abdominal Infection"" receive at least indirect support from the statement: ""Ciprofloxacin is effective in the treatment of serious, non-self-limiting intra-abdominal infections, peritonitis in CAPD, pelvic inflammatory disease, endometritis and gall-bladder infections.""?","Yes, the phrase ""Ciprofloxacin treats Abdominal Infection"" does receive indirect support from the statement: ""Ciprofloxacin is effective in the treatment of serious, non-self-limiting intra-abdominal infections."" - + The rationale behind this is that abdominal infections can be classified as intra-abdominal infections. Specifically, when they become serious and non-self-limiting, they would fall within the scope of conditions for which Ciprofloxacin has demonstrated efficacy based on the provided statement. However, it is important to note that Ciprofloxacin may not be the first-line treatment for all types of abdominal infections; its use depends on factors such as the specific pathogen involved and the patient's overall health status." +8754779,Ciprofloxacin treats rhinoscleroma,1358,We report on a young patient with nasal rhinoscleroma who achieved resolution after treatment with oral ciprofloxacin.,True,"'Does the phrase ""Ciprofloxacin treats rhinoscleroma"" receive at least indirect support from the statement: ""We report on a young patient with nasal rhinoscleroma who achieved resolution after treatment with oral ciprofloxacin.""?","Yes, the statement ""We report on a young patient with nasal rhinoscleroma who achieved resolution after treatment with oral ciprofloxacin"" does provide indirect support for the claim that ""Ciprofloxacin treats rhinoscleroma"". This is because it describes a case where a patient with rhinoscleroma was treated with ciprofloxacin and experienced resolution of their symptoms. However, it's important to note that this is only one case study, which means it doesn't necessarily prove that ciprofloxacin is universally effective for treating rhinoscleroma. More rigorous studies, such as randomized controlled trials, would be needed to confirm this. Additionally, factors such as the dosage of ciprofloxacin used, the severity of the patient's rhinoscleroma, and any other treatments they received could also influence the outcome. Therefore, while this case study does provide some support for the claim, it doesn't definitively prove it." +8350437,Ciprofloxacin treats pyelonephritis,1359,Is a 7-day course of ciprofloxacin effective in the treatment of uncomplicated pyelonephritis in women?,True,"'Does the phrase ""Ciprofloxacin treats pyelonephritis"" receive at least indirect support from the statement: ""Is a 7-day course of ciprofloxacin effective in the treatment of uncomplicated pyelonephritis in women?""?","Yes, the phrase ""Ciprofloxacin treats pyelonephritis"" does receive indirect support from the statement: ""Is a 7-day course of ciprofloxacin effective in the treatment of uncomplicated pyelonephritis in women?"" - To establish causation and draw definitive conclusions about methylprednisolone as an effective treatment for SARS, additional information would be required: + The statement implies that ciprofloxacin is used in treating uncomplicated pyelonephritis in women, which suggests that ciprofloxacin has some therapeutic effect on pyelonephritis. However, it is essential to note that pyelonephritis is not explicitly mentioned in the phrase; instead, it is implied through the context provided in the statement. Additionally, the effectiveness of ciprofloxacin in treating pyelonephritis is contingent on various factors such as dosage, duration of treatment, patient characteristics, bacterial susceptibility, among others; hence, further investigation is necessary for more definitive conclusions." +8337570,Ciprofloxacin treats bacterial infectious disease with sepsis,1360,"Despite prolonged bacteremia, the response to long-term therapy with ciprofloxacin and rifampin was excellent.",True,"'Does the phrase ""Ciprofloxacin treats bacterial infectious disease with sepsis"" receive at least indirect support from the statement: ""Despite prolonged bacteremia, the response to long-term therapy with ciprofloxacin and rifampin was excellent.""?","Yes, the phrase ""Ciprofloxacin treats bacterial infectious disease with sepsis"" does receive indirect support from the statement: ""Despite prolonged bacteremia, the response to long-term therapy with ciprofloxacin and rifampin was excellent."" - + The statement suggests that ciprofloxacin was used in combination therapy for an extended period to treat a bacterial infection (bacteremia). The positive outcome implies that ciprofloxacin was effective against the bacterial infection, providing indirect evidence for its use in treating bacterial infectious diseases. - 1. A control group that did not receive methylprednisolone treatment for comparison purposes - 2. Information on other treatments administered concurrently - 3. Quantitative measures of treatment efficacy (e.g., symptom improvement rates, mortality rates) - 4. Statistical analysis assessing the significance of observed associations - 5. Replication studies" -10289517,Methylprednisolone treats graft versus host disease,1278,"CASE SUMMARY: A 2-year-old white boy with a history of relapsed acute lymphoblastic leukemia underwent a bone marrow transplant and developed graft-versus-host disease, which was treated with methylprednisolone.",True,"Is the triple 'Methylprednisolone treats graft versus host disease' supported by the sentence: 'CASE SUMMARY: A 2-year-old white boy with a history of relapsed acute lymphoblastic leukemia underwent a bone marrow transplant and developed graft-versus-host disease, which was treated with methylprednisolone.'?","Yes, the statement does provide indirect support for the claim that methylprednisolone treats graft versus host disease (GvHD). The case summary states that a patient diagnosed with graft versus host disease was treated with methylprednisolone, implying that the drug was used as part of the therapeutic strategy for managing GvHD. + However, it is important to note that sepsis is a complex condition characterized by a dysregulated host response to infection rather than simply an infection itself (Singer et al., 2016). Therefore, while ciprofloxacin may be useful in treating bacterial infections that can lead to sepsis, it does not specifically treat sepsis itself. - However, it is important to note that correlation does not imply causation, and while methylprednisolone was used in treating GvHD in this case, it does not necessarily mean that methylprednisolone is solely responsible for treating GvHD in all cases. Further investigation into clinical trials, peer-reviewed studies, and meta-analyses would be required to establish more robust evidence supporting methylprednisolone as an effective treatment for GvHD. + Furthermore, the statement mentions combination therapy with rifampin. This suggests that ciprofloxacin may not always be used alone in treating bacterial" +8194797,Ciprofloxacin treats neutropenia,1361,The proportion of patients who developed neutropenia and fever was 87% in the group treated with ciprofloxacin and 78% in the group treated with ciprofloxacin and rifampin (P =.25).,False,"'Does the phrase ""Ciprofloxacin treats neutropenia"" receive at least indirect support from the statement: ""The proportion of patients who developed neutropenia and fever was 87% in the group treated with ciprofloxacin and 78% in the group treated with ciprofloxacin and rifampin (P =.25).""?","No, the statement does not provide indirect support for the phrase ""Ciprofloxacin treats neutropenia."" The statement compares two groups of patients treated with different regimens containing ciprofloxacin - one group receiving ciprofloxacin alone and another group receiving ciprofloxacin in combination with rifampin - in terms of their rates of developing neutropenia (low white blood cell count) and fever. The rates of these adverse events were slightly higher in the ciprofloxacin-only group (87%), but not significantly so (P = .25). This finding does not suggest that ciprofloxacin treats neutropenia; on the contrary, it indicates that ciprofloxacin may not prevent neutropenia. - Additionally, it should be considered that treatment decisions in clinical settings can be influenced by various factors such as comorbidities, potential side effects, patient preferences, and concomitant medications. Therefore, while this case summary supports methylprednisolone as an option for treating GvHD, it is crucial to consider other evidence in order to make well-" -10221573,Methylprednisolone treats myeloproliferative neoplasm,1279,The effects of HDMP should be explored in patients with other subtypes of AML who present with MT.,False,Is the triple 'Methylprednisolone treats myeloproliferative neoplasm' supported by the sentence: 'The effects of HDMP should be explored in patients with other subtypes of AML who present with MT.'?,"No, the phrase ""Methylprednisolone treats myeloproliferative neoplasm"" does not receive indirect support from the statement: ""The effects of HDMP should be explored in patients with other subtypes of AML who present with MT."" + Neutropenia is generally treated using growth factors (e.g., granulocyte colony-stimulating factor) that stimulate white blood cell production in the bone marrow or by adjusting medications that cause neutropenia as side effects. Antibiotics like ciprofloxac" +8190776,Ciprofloxacin treats peritonitis,1362,"Peritonitis due to S. aureus ESI was significantly less frequent among patients treated with ciprofloxacin (1 vs 9 cases, p = 0.001).",True,"'Does the phrase ""Ciprofloxacin treats peritonitis"" receive at least indirect support from the statement: ""Peritonitis due to S. aureus ESI was significantly less frequent among patients treated with ciprofloxacin (1 vs 9 cases, p = 0.001).""?","Yes, the statement ""Peritonitis due to S. aureus ESI was significantly less frequent among patients treated with ciprofloxacin (1 vs 9 cases, p = 0.001)"" does provide indirect support for the claim that ""Ciprofloxacin treats peritonitis."" The study indicates that there is a statistically significant difference in peritonitis cases between patients treated with ciprofloxacin versus those not treated with it (p = 0.001). With only one case of peritonitis in patients receiving ciprofloxacin compared to nine cases in patients not receiving it, there is evidence suggesting that ciprofloxacin may help in treating peritonitis caused by S. aureus ESI. However, it is important to consider that correlation does not necessarily imply causation; further studies would be required to definitively establish ciprofloxacin as an effective treatment for peritonitis caused by S. aureus ESI." +8088120,Ciprofloxacin treats Fever,1363,"In the current study, the authors examined the use of ciprofloxacin as outpatient management in selected patients with fever during an episode of neutropenia.",False,"'Does the phrase ""Ciprofloxacin treats Fever"" receive at least indirect support from the statement: ""In the current study, the authors examined the use of ciprofloxacin as outpatient management in selected patients with fever during an episode of neutropenia.""?","No, the phrase ""Ciprofloxacin treats Fever"" does not receive at least indirect support from the statement: ""In the current study, the authors examined the use of ciprofloxacin as outpatient management in selected patients with fever during an episode of neutropenia."" - The statement in question refers to High-Dose Methylprednisolone (HDMP) and its potential effects on certain subtypes of Acute Myeloid Leukemia (AML) that present with Measurable Residual Disease (MRD). This statement does not make any direct or indirect reference to Methylprednisolone being an effective treatment for Myeloproliferative Neoplasms (MPNs). + The statement from the study indicates that ciprofloxacin was used for outpatient management of fever in neutropenic patients, not that it treats fever itself. Neutropenia is a condition characterized by an abnormally low number of neutrophils (a type of white blood cell that fights infection), making patients more susceptible to infections, which can cause fever. - Myeloproliferative Neoplasms (MPNs) and Acute Myeloid Leukemia (AML) are two distinct types of hematological malignancies with different pathophysiological features, risk factors, clinical presentations, and treatment approaches. Therefore, evidence supporting treatment options for one condition cannot be indirectly inferred for another condition based solely on shared terminology (myeloid in this case) without explicit mention in the statement itself." -10136260,Methylprednisolone treats acute lymphoblastic leukemia,1280,"We examined the effect of high-dose methylprednisolone (HDMP) on blast reduction rate and compared it to conventional dose steroid treatment, administered during the first 7+ days of the induction remission period in patients with acute lymphoblastic leukemia (ALL).",True,"Is the triple 'Methylprednisolone treats acute lymphoblastic leukemia' supported by the sentence: 'We examined the effect of high-dose methylprednisolone (HDMP) on blast reduction rate and compared it to conventional dose steroid treatment, administered during the first 7+ days of the induction remission period in patients with acute lymphoblastic leukemia (ALL).'?","Yes, indirect support can be inferred from the statement provided. The study examined the effect of high-dose methylprednisolone (HDMP) on blast reduction rate in patients with acute lymphoblastic leukemia (ALL). The fact that they compared it to conventional dose steroid treatment implies that methylprednisolone is being considered as a potential treatment for ALL, which is a form of leukemia. + Although ciprofloxacin is an antibiotic that can help manage infections and may lead to fever reduction as a secondary effect, it does not specifically treat fever as fever is a symptom of an underlying condition rather than a condition that can be treated independently. Therefore, there is no indirect support for the claim that ""Ciprofloxacin treats Fever"" based on the provided statement from the study." +7880629,Ciprofloxacin treats osteomyelitis,1364,"The efficacy and safety of three oral fluoroquinolones (lomefloxacin, levofloxacin, and ciprofloxacin) for the treatment of chronic osteomyelitis were analyzed.",True,"'Does the phrase ""Ciprofloxacin treats osteomyelitis"" receive at least indirect support from the statement: ""The efficacy and safety of three oral fluoroquinolones (lomefloxacin, levofloxacin, and ciprofloxacin) for the treatment of chronic osteomyelitis were analyzed.""?","Yes, the statement does provide indirect support for the claim that ""Ciprofloxacin treats osteomyelitis."" This is because it mentions that ciprofloxacin is one of three oral fluoroquinolones analyzed for their efficacy and safety in treating chronic osteomyelitis. However, it is important to note that indirect support does not equate to definitive proof of efficacy, as it doesn't provide information on whether ciprofloxacin was found to be effective specifically, nor does it account for other potential factors such as dosage or duration of treatment." +7798648,Ciprofloxacin treats cystic fibrosis,1365,"As juveniles are especially sensitive, use of these drugs in paediatrics should be restricted to carefully selected indications (such as the use of ciprofloxacin in cystic fibrosis).",True,"'Does the phrase ""Ciprofloxacin treats cystic fibrosis"" receive at least indirect support from the statement: ""As juveniles are especially sensitive, use of these drugs in paediatrics should be restricted to carefully selected indications (such as the use of ciprofloxacin in cystic fibrosis).""?","Yes, the statement does provide indirect support for the phrase ""Ciprofloxacin treats cystic fibrosis."" The key phrase here is ""the use of ciprofloxacin in cystic fibrosis."" This implies that ciprofloxacin has some therapeutic value in treating cystic fibrosis, even though it doesn't explicitly state that it cures or eliminates the disease. - However, it is important to note that while this statement suggests methylprednisolone may have some positive effect on ALL treatment, it does not explicitly state that methylprednisolone ""treats"" ALL. The term ""treats"" implies that it is an established therapy for ALL, which cannot be concluded from this statement alone. + However, it's important to note that ciprofloxacin is an antibiotic commonly used to treat various bacterial infections, not a specific treatment for cystic fibrosis itself. Cystic fibrosis is a genetic disorder that primarily affects the lungs, causing chronic infections. Therefore, while ciprofloxacin may be used to manage some symptoms of cystic fibrosis by treating secondary infections, it does not treat the underlying cause of the disease. - Furthermore, the study only looked at blast reduction rate, which is one aspect of leukemia treatment. Other factors such as overall survival rate, side effects, and long-term impacts would also need to be considered when evaluating whether methylprednisolone is an effective treatment for ALL. Therefore, while there is some indirect support for methylprednisolone being used in ALL treatment" -10049014,"Methylprednisolone treats dermatitis, atopic",1281,"The objective of this multicentre, parallel, blinded, randomized controlled study was to evaluate the efficacy and the safety of cyclosporine (CsA group, 117 dogs) in comparison with methylprednisolone (MP group, 59 dogs) in the treatment of atopic dermatitis for 4 months.",True,"Is the triple 'Methylprednisolone treats dermatitis, atopic' supported by the sentence: 'The objective of this multicentre, parallel, blinded, randomized controlled study was to evaluate the efficacy and the safety of cyclosporine (CsA group, 117 dogs) in comparison with methylprednisolone (MP group, 59 dogs) in the treatment of atopic dermatitis for 4 months.'?","Yes, the statement does provide indirect support for the claim that ""Methylprednisolone treats dermatitis, atopic"". The study mentioned is designed to compare the efficacy and safety of cyclosporine (CsA) and methylprednisolone (MP) in treating atopic dermatitis in dogs over four months. By participating in such a study, it suggests that methylprednisolone has been considered as a potential treatment option for atopic dermatitis by researchers in this field. + Additionally, the statement highlights that juveniles are especially sensitive to these drugs, suggesting that while ciprofloxacin may be used in paediatric cystic fibrosis cases," +7544699,Ciprofloxacin treats diarrheal disease,1366,The aim of this study was to investigate clinical importance of ciprofloxacin efficacy in treatment of massive diarrhoea in patients after extensional bowel resection with removing of ileo-coecal valve (EBR + ICVR).,True,"'Does the phrase ""Ciprofloxacin treats diarrheal disease"" receive at least indirect support from the statement: ""The aim of this study was to investigate clinical importance of ciprofloxacin efficacy in treatment of massive diarrhoea in patients after extensional bowel resection with removing of ileo-coecal valve (EBR + ICVR).""?","Yes, the statement does provide indirect support for the phrase ""Ciprofloxacin treats diarrheal disease"". The study aims to investigate the clinical importance of ciprofloxacin efficacy in treating massive diarrhea in patients after undergoing specific surgical procedures (EBR + ICVR). This implies that ciprofloxacin is being used as a potential treatment for diarrheal symptoms in these patients, thus providing indirect evidence that ciprofloxacin can be used to treat diarrheal disease. However, it is important to note that direct evidence of ciprofloxacin's efficacy in treating diarrheal disease would require studies specifically designed to test its effectiveness in treating diarrhea, regardless of surgical history or other factors." +7423320,Ciprofloxacin treats typhoid fever,1367,"To compare clinical and bacteriological efficacies of azithromycin and ciprofloxacin for typhoid fever, 123 adults with fever and signs of uncomplicated typhoid fever were entered into a randomized trial.",True,"'Does the phrase ""Ciprofloxacin treats typhoid fever"" receive at least indirect support from the statement: ""To compare clinical and bacteriological efficacies of azithromycin and ciprofloxacin for typhoid fever, 123 adults with fever and signs of uncomplicated typhoid fever were entered into a randomized trial.""?","Yes, indirectly it does support the claim that Ciprofloxacin treats typhoid fever. The statement provides evidence of a randomized trial involving adults with uncomplicated typhoid fever who were treated with Ciprofloxacin. The fact that such a trial was conducted suggests that there is some basis for believing that Ciprofloxacin could be an effective treatment for typhoid fever. However, it does not provide direct evidence of Ciprofloxacin's efficacy, as it does not report on the outcomes of the trial. Therefore, further investigation would be needed to definitively confirm whether Ciprofloxacin is an effective treatment for typhoid fever." +7337248,Ciprofloxacin treats pneumonia,1368,Initial treatment of severe pneumonia with ciprofloxacin resulted in significantly less subsequent gram-negative infection and was associated with substantially lower curative costs.,True,"'Does the phrase ""Ciprofloxacin treats pneumonia"" receive at least indirect support from the statement: ""Initial treatment of severe pneumonia with ciprofloxacin resulted in significantly less subsequent gram-negative infection and was associated with substantially lower curative costs.""?","Yes, the statement does provide indirect support for the phrase ""Ciprofloxacin treats pneumonia."" The statement indicates that initial treatment of severe pneumonia with ciprofloxacin led to significantly less subsequent gram-negative infection. This suggests that ciprofloxacin is effective in treating pneumonia caused by gram-negative bacteria, which is a common cause of pneumonia. The lower curative costs associated with ciprofloxacin treatment also imply that it is a cost-effective option for treating pneumonia. However, it is important to note that pneumonia can be caused by various types of bacteria, viruses, and fungi, and that ciprofloxacin is not effective against all of these pathogens. Therefore, while the statement does provide some support for the idea that ciprofloxacin can be used to treat pneumonia, it does not necessarily mean that ciprofloxacin is always the best option for treating pneumonia in all cases." +7228759,Ciprofloxacin treats infectious disease,1369,"Ciprofloxacin (CIP), a fluoroquinolone antibacterial drug, is widely used in the treatment of serious infections in humans.",True,"'Does the phrase ""Ciprofloxacin treats infectious disease"" receive at least indirect support from the statement: ""Ciprofloxacin (CIP), a fluoroquinolone antibacterial drug, is widely used in the treatment of serious infections in humans.""?","Yes, the phrase ""Ciprofloxacin treats infectious disease"" does receive indirect support from the statement: ""Ciprofloxacin (CIP), a fluoroquinolone antibacterial drug, is widely used in the treatment of serious infections in humans."" - However, it is important to note that indirect support does not equate to definitive proof. The study does not explicitly state that methylprednisolone treats atopic dermatitis; rather it investigates its efficacy in comparison to another treatment option. Further evidence from additional studies would be required for stronger support for the claim that methylprednisolone treats atopic dermatitis in dogs." -9980473,Methylprednisolone treats immunoglobulin a vasculitis,1282,"CASE DESCRIPTION: A 33-year-old woman previously treated with methylprednisolone and cyclophosphamide for Henoch-Schonlein purpura was transferred from a referring hospital because of sore throat, fever, and chills.",False,"Is the triple 'Methylprednisolone treats immunoglobulin a vasculitis' supported by the sentence: 'CASE DESCRIPTION: A 33-year-old woman previously treated with methylprednisolone and cyclophosphamide for Henoch-Schonlein purpura was transferred from a referring hospital because of sore throat, fever, and chills.'?","No, the statement does not provide direct support for the claim that ""Methylprednisolone treats immunoglobulin A vasculitis (IgAV)"". The case description refers to a patient with Henoch-Schonlein purpura (HSP), which is closely related but distinct from IgAV. The patient was treated previously with methylprednisolone and cyclophosphamide, but no information is provided about her response to treatment or whether her condition was indeed IgAV. Therefore, it is impossible to determine whether methylprednisolone is effective in treating IgAV based on this statement alone. However, methylprednisolone is commonly used in treating various vasculitides including IgAV due to its anti-inflammatory properties." -9720542,Methylprednisolone treats lupus nephritis,1283,The last significant breakthrough in the treatment of systemic lupus erythematosus (SLE) was the use of cyclophosphamide and methylprednisolone in the treatment of lupus nephritis.,True,Is the triple 'Methylprednisolone treats lupus nephritis' supported by the sentence: 'The last significant breakthrough in the treatment of systemic lupus erythematosus (SLE) was the use of cyclophosphamide and methylprednisolone in the treatment of lupus nephritis.'?,"Yes, the statement does provide indirect support for the claim that methylprednisolone treats lupus nephritis. The key word here is 'indirect'. The statement suggests that cyclophosphamide and methylprednisolone were used together in treating lupus nephritis, which implies that methylprednisolone has some therapeutic effect on lupus nephritis. However, it does not directly prove that methylprednisolone alone is effective in treating lupus nephritis. It is important to note that clinical trials and further research would be necessary to establish a direct causal relationship between methylprednisolone and improvement in lupus nephritis symptoms." -8761529,Methylprednisolone treats asthma,1284,Methylprednisolone suleptanate (Promedrol) is a prodrug of methylprednisolone being developed by Pharmacia Corp (formerly Pharmacia & Upjohn) for the treatment of asthma.,True,Is the triple 'Methylprednisolone treats asthma' supported by the sentence: 'Methylprednisolone suleptanate (Promedrol) is a prodrug of methylprednisolone being developed by Pharmacia Corp (formerly Pharmacia & Upjohn) for the treatment of asthma.'?,"Yes, there is indirect support for the claim that Methylprednisolone treats asthma based on the provided statement. + The statement indicates that Ciprofloxacin (CIP) is an antibacterial drug used for treating severe infections in humans. Antibacterial drugs target bacterial infections by either killing bacteria or inhibiting their growth (CDC, 2021). Infectious diseases can be caused by various microorganisms like bacteria (WHO, 2021). Since Ciprofloxacin is used for treating bacterial infections in humans, it implies that Ciprofloxacin indeed helps manage infectious diseases indirectly by tackling bacterial infections that contribute to these diseases. - - Methylprednisolone suleptanate (Promedrol) is indeed a prodrug of methylprednisolone being developed by Pharmacia Corp (formerly Pharmacia & Upjohn) for the treatment of asthma. A prodrug is an inactive form of a drug that is metabolically converted into its active form in the body after administration (Stella, 1985). In this case, Methylprednisolone suleptanate (Promedrol) is metabolized into Methylprednisolone after being administered. + References: + Centers for Disease Control and Prevention (CDC). (2021). Antibiotic/Antimicrobial Resistance. Retrieved from https://www.cdc.gov/d" +7163480,Ciprofloxacin treats Crohn disease,1370,Use of antibiotics in the treatment of active Crohn's disease: experience with metronidazole and ciprofloxacin.,True,"'Does the phrase ""Ciprofloxacin treats Crohn disease"" receive at least indirect support from the statement: ""Use of antibiotics in the treatment of active Crohn's disease: experience with metronidazole and ciprofloxacin.""?","Yes, indirect support can be inferred from the statement ""Use of antibiotics in the treatment of active Crohn's disease: experience with metronidazole and ciprofloxacin."" This suggests that ciprofloxacin has been used in treating Crohn's disease, but it does not explicitly state that ciprofloxacin treats Crohn disease. A direct cause-and-effect relationship is not established in this statement alone; therefore, further evidence would be needed for unequivocal support of the claim that ""Ciprofloxacin treats Crohn disease."" - - Methylprednisolone is a type of corticosteroid that is commonly used in treating asthma due to its anti-inflammatory properties (National Asthma Education Prevention Program, 2007). Corticosteroids reduce inflammation in airways by suppressing immune cells that release chemicals causing inflammation (Barnes, 2013)." -8588816,Methylprednisolone treats Bell's palsy,1285,"On these basis, we have studied the efficacity of parenteral association of 30 mg/Kg/j of Aciclovir and 1 mg/Kg/j of Methylprednisolone in the treatment of Bell's palsy with less than 12 days of evolution.",True,"Is the triple 'Methylprednisolone treats Bell's palsy' supported by the sentence: 'On these basis, we have studied the efficacity of parenteral association of 30 mg/Kg/j of Aciclovir and 1 mg/Kg/j of Methylprednisolone in the treatment of Bell's palsy with less than 12 days of evolution.'?","Yes, indirectly it does support that Methylprednisolone can be used in treating Bell's palsy. The statement mentions a study where patients with Bell's palsy of less than 12 days evolution were treated with Aciclovir and Methylprednisolone in combination. This implies that Methylprednisolone is considered as a potential treatment for Bell's palsy in medical literature. + In order to establish direct support for the claim that ciprofloxacin treats Crohn disease, well-designed clinical trials demonstrating efficacy would be required. The provided statement describes experience in using ciprofloxacin for treating Crohn disease but does not provide any specific outcomes or results that would definitively support its use as a treatment for Crohn disease. - - However, it is important to note that this statement does not provide direct evidence that Methylprednisolone alone treats Bell's palsy effectively. It only suggests that it has been used in conjunction with Aciclovir in treating Bell's palsy within 12 days of onset. Further research would be needed to establish whether Methylprednisolone is an effective monotherapy for Bell's palsy. + It is important to note that antibiotics like ciprofloxacin may be used as part of a treatment regimen for Crohn disease" +10607698,Chloramphenicol treats bacterial infectious disease,1371,[Experiences with a chloramphenicol preparation for intramuscular injection in bacterial infections of the CNS].,True,"'Does the phrase ""Chloramphenicol treats bacterial infectious disease"" receive at least indirect support from the statement: ""[Experiences with a chloramphenicol preparation for intramuscular injection in bacterial infections of the CNS].""?","Yes, the phrase ""Chloramphenicol treats bacterial infectious disease"" does receive indirect support from the statement: ""[Experiences with a chloramphenicol preparation for intramuscular injection in bacterial infections of the CNS]."" - - Also, it should be noted that while Methylprednisolone is often used in treating Bell's palsy due to its anti-inflammatory effects, its usage should be under medical supervision due to potential side effects such as increased blood sugar" -8568939,Methylprednisolone treats myasthenia gravis,1286,"Treatment with methylprednisolone for myasthenia gravis was associated with a marked decrease in both biochemical markers of bone formation and resorption without any changes in endogenous cAMP and serum levels of calcium, PTH, and 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3].",False,"Is the triple 'Methylprednisolone treats myasthenia gravis' supported by the sentence: 'Treatment with methylprednisolone for myasthenia gravis was associated with a marked decrease in both biochemical markers of bone formation and resorption without any changes in endogenous cAMP and serum levels of calcium, PTH, and 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3].'?","No, the statement does not provide direct or indirect support for the claim that methylprednisolone treats myasthenia gravis. The statement focuses on the impact of methylprednisolone treatment on bone formation and resorption markers as well as calcium metabolism in patients with myasthenia gravis [1]. It does not provide any information about the efficacy of methylprednisolone in treating myasthenia gravis symptoms or improving patients' clinical status. + The statement suggests that chloramphenicol has been used in treating bacterial infections of the central nervous system (CNS), which is a specific type of bacterial infection. Chloramphenicol is an antibiotic that works by stopping bacterial growth. Thus, it supports the claim that chloramphenicol can be used to treat bacterial infectious diseases, although it is important to note that its effectiveness may vary depending on the type of bacteria causing the infection and the patient's overall health condition. - Myasthenia gravis is an autoimmune neuromuscular disorder characterized by muscle weakness [2]. Treatment options include cholinesterase inhibitors, corticosteroids (such as methylprednisolone), immunosuppressive drugs, plasma exchange, and intravenous immunoglobulin [3]. Therefore, further evidence is required to establish whether methylprednisolone indeed effectively treats myasthenia gravis. + However, it is crucial to consider that using antibiotics should be based on appropriate diagnosis and prescription by healthcare professionals since inappropriate use can lead to antibiotic resistance—a significant global health concern." +9528501,Chloramphenicol treats osteomyelitis,1372,A 2-month-old infant with Enterobacter osteomyelitis complicating total parenteral nutrition was successfully treated with rifampicin and chloramphenicol.,True,"'Does the phrase ""Chloramphenicol treats osteomyelitis"" receive at least indirect support from the statement: ""A 2-month-old infant with Enterobacter osteomyelitis complicating total parenteral nutrition was successfully treated with rifampicin and chloramphenicol.""?","Yes, the statement does provide indirect support for the phrase ""Chloramphenicol treats osteomyelitis."" The case describes an infant with Enterobacter osteomyelitis who was successfully treated using chloramphenicol in combination with rifampicin. This suggests that chloramphenicol had an effective therapeutic response against osteomyelitis in this particular case. However, it is important to note that antibiotic treatment success can be influenced by various factors such as patient-specific factors (age, immune status), bacterial susceptibility, duration of treatment, and potential synergistic effects of combined therapies like in this case where both rifampicin and chloramphenicol were used together. Therefore, while there is some support for chloramphenicol treating osteomyelitis from this statement, it does not necessarily confirm that chloramphenicol alone would be sufficient for treating osteomyelitis in all cases." +7351604,Chloramphenicol treats eye infectious disorder,1373,"The writers consult a wide range of American, European and British research from 1950 to the present to reassure readers that ophthalmic chloramphenicol is a demonstrably effective, safe, cost-effective treatment for most superficial eye infections.",True,"'Does the phrase ""Chloramphenicol treats eye infectious disorder"" receive at least indirect support from the statement: ""The writers consult a wide range of American, European and British research from 1950 to the present to reassure readers that ophthalmic chloramphenicol is a demonstrably effective, safe, cost-effective treatment for most superficial eye infections.""?","Yes, the statement does provide indirect support for the claim that chloramphenicol treats eye infectious disorders. The writers' consultation of a wide range of American, European, and British research from 1950 to the present suggests they have conducted an extensive review of existing literature on the topic. Their assurance that ophthalmic chloramphenicol is an effective, safe, and cost-effective treatment for most superficial eye infections implies that there is evidence supporting chloramphenicol's positive impact on treating eye infections. - References: - 1. Verschueren P, et al. Glucocorticoid-induced bone loss in myasthenia gravis: effect of methylprednisolone pulse therapy on" -8562694,Methylprednisolone treats endocrine exophthalmos,1287,PATIENTS AND METHODS: Fourteen euthyroid patients with severe Graves' ophthalmopathy were treated with high-dose intravenous methylprednisolone during 6 months and followed-up for 24-48 months by clinical and ophthalmological assessment.,True,Is the triple 'Methylprednisolone treats endocrine exophthalmos' supported by the sentence: 'PATIENTS AND METHODS: Fourteen euthyroid patients with severe Graves' ophthalmopathy were treated with high-dose intravenous methylprednisolone during 6 months and followed-up for 24-48 months by clinical and ophthalmological assessment.'?,"Yes, the statement does provide indirect support for the claim that methylprednisolone treats endocrine exophthalmos (a symptom of Graves' ophthalmopathy). The patients in question had severe Graves' ophthalmopathy and were treated with high-dose intravenous methylprednisolone for six months. The follow-up period also suggests that there was an interest in tracking the long-term effects of this treatment. + However, it is essential to note that while this statement offers some level of support for chloramphenicol as an effective treatment for eye infections, it does not constitute direct evidence for its effectiveness in treating all eye infectious disorders. The specificity of chloramphenicol's applicability for treating various eye infections may vary depending on factors such as infection type, severity, duration, and potential side-effects. - However, it is important to note that while this study design suggests that methylprednisolone may have therapeutic benefits for Graves' ophthalmopathy, it does not definitively prove that it treats endocrine exophthalmos specifically. The study does not detail the specific symptoms each patient experienced before and after treatment, nor does it explicitly state that endocrine exophthalmos was alleviated by methylprednisolone treatment. Further studies would be needed to explicitly test this claim." -8503951,Methylprednisolone treats ulcerative colitis,1288,The current study evaluated the efficacy and safety of unfractionated heparin in the treatment of ulcerative colitis in comparison with methylprednisolone.,True,Is the triple 'Methylprednisolone treats ulcerative colitis' supported by the sentence: 'The current study evaluated the efficacy and safety of unfractionated heparin in the treatment of ulcerative colitis in comparison with methylprednisolone.'?,"Yes, based on the statement provided, there is indirect support for the claim that methylprednisolone treats ulcerative colitis. The study in question compared unfractionated heparin and methylprednisolone in treating ulcerative colitis. The fact that methylprednisolone was included in such a study implies that it is considered a potential treatment option for ulcerative colitis. However, it is important to note that indirect support does not equate to definitive proof; further investigation would be necessary to establish the efficacy and safety of methylprednisolone specifically for ulcerative colitis treatment." -8464737,Methylprednisolone treats kidney disorder,1289,"Post partum acute renal failure and type IV lupus nephropathy were treated with hemodialysis, methylprednisolone, cyclophosphamide and prednisone.",True,"Is the triple 'Methylprednisolone treats kidney disorder' supported by the sentence: 'Post partum acute renal failure and type IV lupus nephropathy were treated with hemodialysis, methylprednisolone, cyclophosphamide and prednisone.'?","Yes, the statement does provide indirect support for the phrase ""Methylprednisolone treats kidney disorder"". The statement indicates that methylprednisolone was used in the treatment of post partum acute renal failure and type IV lupus nephropathy. This suggests that methylprednisolone is considered effective in treating certain kidney disorders, even though it was used in conjunction with other treatments in this case. However, it is important to note that this does not constitute direct evidence that methylprednisolone alone treats kidney disorders, as it was used in combination with other treatments in this instance." -8427466,Methylprednisolone treats sinusitis,1290,"To resolve the controversy over whether corticosteroids promote or inhibit the resolution of sinusitis, we present a prospective study of 80 rabbits with surgically introduced pseudomonal sinusitis that were then treated in one of four arms: control, ceftazidime, methylprednisolone, and ceftazidime with methylprednisolone.",False,"Is the triple 'Methylprednisolone treats sinusitis' supported by the sentence: 'To resolve the controversy over whether corticosteroids promote or inhibit the resolution of sinusitis, we present a prospective study of 80 rabbits with surgically introduced pseudomonal sinusitis that were then treated in one of four arms: control, ceftazidime, methylprednisolone, and ceftazidime with methylprednisolone.'?","No, the statement does not provide direct support for the claim that methylprednisolone treats sinusitis. The study described in the statement investigates the effect of corticosteroids (including methylprednisolone) on pseudomonal sinusitis in rabbits, but it does not explicitly assess whether methylprednisolone is an effective treatment for sinusitis. The study is also conducted in rabbits, which may not translate directly to humans. Therefore, further investigation is needed before concluding that methylprednisolone treats sinusitis in humans." -8330903,Methylprednisolone treats systemic lupus erythematosus,1291,MAIN RESULTS: We found no randomised controlled trials comparing cyclophosphamide versus methylprednisolone for the treatment of neuropsychiatric involvement in the systemic lupus erythematosus.,False,Is the triple 'Methylprednisolone treats systemic lupus erythematosus' supported by the sentence: 'MAIN RESULTS: We found no randomised controlled trials comparing cyclophosphamide versus methylprednisolone for the treatment of neuropsychiatric involvement in the systemic lupus erythematosus.'?,"No, the statement does not provide indirect support for the claim that ""Methylprednisolone treats systemic lupus erythematosus."" The provided statement is from a systematic review examining randomized controlled trials comparing cyclophosphamide versus methylprednisolone for treating neuropsychiatric involvement in systemic lupus erythematosus (SLE). The absence of such trials does not imply that methylprednisolone is an effective treatment for SLE in general or that it treats neuropsychiatric involvement specifically. + In addition, it is crucial to consider that while the statement refers to ""most superficial eye infections,"" it does not explicitly specify which superficial eye infections chloramphenicol has been proven effective in" +24500158,Rebamipide treats gastroesophageal reflux disease,1374,Frequently reported adverse events of rebamipide compared to other drugs for peptic ulcer and gastroesophageal reflux disease.,False,"'Does the phrase ""Rebamipide treats gastroesophageal reflux disease"" receive at least indirect support from the statement: ""Frequently reported adverse events of rebamipide compared to other drugs for peptic ulcer and gastroesophageal reflux disease.""?","No, the statement does not provide direct or indirect support for the claim that ""Rebamipide treats gastroesophageal reflux disease."" The provided statement discusses adverse events associated with rebamipide compared to other drugs for peptic ulcer and gastroesophageal reflux disease (GERD). While it implies that rebamipide is used in treating GERD, it does not provide evidence that rebamipide is effective in treating GERD or that it is specifically used for that purpose. Therefore, it does not support the initial claim." +19949890,Rebamipide treats osteoarthritis,1375,We also discuss the potential role of rebamipide to serve as a new strategy for the treatment of TMJ-OA.,True,"'Does the phrase ""Rebamipide treats osteoarthritis"" receive at least indirect support from the statement: ""We also discuss the potential role of rebamipide to serve as a new strategy for the treatment of TMJ-OA.""?","Yes, there is indirect support for the claim that rebamipide treats osteoarthritis (OA) in the statement ""We also discuss the potential role of rebamipide to serve as a new strategy for the treatment of TMJ-OA."" The abbreviation TMJ-OA stands for temporomandibular joint osteoarthritis, which is a specific form of osteoarthritis affecting the temporomandibular joint. - To provide indirect support for methylprednisolone as an effective treatment for SLE, there should be evidence showing its positive effects compared to other treatments (such as cyclophosphamide) in treating SLE or its symptoms in general. The statement only indicates that there is no evidence specifically comparing these two treatments in relation to neuropsychiatric involvement in SLE." -8291810,Methylprednisolone treats pneumonia,1292,High-dose methylprednisolone was administered for treatment of the pneumonitis.,True,Is the triple 'Methylprednisolone treats pneumonia' supported by the sentence: 'High-dose methylprednisolone was administered for treatment of the pneumonitis.'?,"Yes, indirectly it does support that statement because methylprednisolone is a type of corticosteroid often used in treating inflammation associated with various conditions including pneumonitis (inflammation of lung tissue often due to infection or injury). However, while this suggests methylprednisolone may be beneficial in treating symptoms caused by pneumonia-related pneumonitis, it does not explicitly confirm that methylprednisolone treats pneumonia itself. The original claim is more general than what is supported by the provided statement." -8227578,Methylprednisolone treats mucocutaneous lymph node syndrome,1293,"Additional antiinflammatory therapy, such as IV methylprednisolone and IV cyclophosphamide, may be helpful in treating persistent KD.",True,"Is the triple 'Methylprednisolone treats mucocutaneous lymph node syndrome' supported by the sentence: 'Additional antiinflammatory therapy, such as IV methylprednisolone and IV cyclophosphamide, may be helpful in treating persistent KD.'?","Yes, the statement does provide indirect support for the phrase ""Methylprednisolone treats mucocutaneous lymph node syndrome"" (Kawasaki Disease or KD). The statement suggests that methylprednisolone can be helpful in treating persistent KD, which is a form of mucocutaneous lymph node syndrome. Although it does not explicitly confirm that methylprednisolone treats KD, it implies that methylprednisolone has therapeutic benefits for KD patients, thus offering indirect support for the claim that methylprednisolone is an effective treatment for mucocutaneous lymph node syndrome. + The key aspect that provides indirect support is that rebamipide is mentioned in relation to treating osteoarthritis (OA), specifically TMJ-OA. This implies that rebamipide may have beneficial effects on osteoarthritis symptoms in general or in particular contexts. However, it is essential to note that direct support for rebamipide treating osteoarthritis would require more robust evidence from clinical trials specifically designed to assess its effectiveness in treating osteoarthritis in various joints. - However, it is important to note that further investigation is necessary for more definitive conclusions as multiple factors can influence treatment outcomes for complex medical conditions like KD. These factors include patient characteristics (e.g., age, severity of symptoms), comorbidities (e.g., allergies, concurrent infections), dosage regimens, potential side effects, as well as alternative treatment options (e.g., aspirin, intravenous immunoglobulin). Additionally, randomized controlled trials (" -8095661,Methylprednisolone treats carpal tunnel syndrome,1294,Injection with methylprednisolone for carpal tunnel syndrome.,True,Is the triple 'Methylprednisolone treats carpal tunnel syndrome' supported by the sentence: 'Injection with methylprednisolone for carpal tunnel syndrome.'?,"Yes, the statement ""Injection with methylprednisolone for carpal tunnel syndrome"" does provide indirect support for the claim that ""Methylprednisolone treats carpal tunnel syndrome."" The use of methylprednisolone injections for carpal tunnel syndrome implies that methylprednisolone plays an active role in treating the condition by reducing inflammation in the carpal tunnel area. This evidence does not explicitly prove that methylprednisolone treats carpal tunnel syndrome but offers support for its therapeutic potential in managing the condition. However, it is essential to consider additional evidence from clinical trials and systematic reviews that assess the overall effectiveness of methylprednisolone in treating carpal tunnel syndrome for a more robust evaluation of the claim." -8083160,Methylprednisolone treats thrombocytopenia,1295,"After a course of high-dose methylprednisolone therapy with a diagnosis of Evans syndrome, complete response for thrombocytopenia and partial response for anemia was achieved.",True,"Is the triple 'Methylprednisolone treats thrombocytopenia' supported by the sentence: 'After a course of high-dose methylprednisolone therapy with a diagnosis of Evans syndrome, complete response for thrombocytopenia and partial response for anemia was achieved.'?","Yes, the statement does provide indirect support for the phrase ""Methylprednisolone treats thrombocytopenia"". The reason is that thrombocytopenia is mentioned as having achieved complete response after a course of high-dose methylprednisolone therapy in a patient diagnosed with Evans syndrome, which suggests that methylprednisolone had a positive impact on treating thrombocytopenia in this particular case. However, it is important to note that this is an observational finding in one case, so further studies would be needed to establish a definitive causal relationship between methylprednisolone treatment and thrombocytopenia improvement in a broader population." -8063034,Methylprednisolone treats granulomatosis with polyangiitis,1296,We describe a 44-year-old man with Wegener's granulomatosis who was treated with cyclophosphamide and methylprednisolone and who subsequently developed bilateral CMVR.,True,Is the triple 'Methylprednisolone treats granulomatosis with polyangiitis' supported by the sentence: 'We describe a 44-year-old man with Wegener's granulomatosis who was treated with cyclophosphamide and methylprednisolone and who subsequently developed bilateral CMVR.'?,"Yes, indirect support can be inferred from the statement provided for the phrase ""Methylprednisolone treats granulomatosis with polyangiitis"". The patient in question was diagnosed with Wegener's granulomatosis (a type of granulomatosis with polyangiitis) and was treated using methylprednisolone in combination with cyclophosphamide. The fact that they received methylprednisolone as part of their treatment regimen suggests that it was considered an appropriate therapeutic option for granulomatosis with polyangiitis by the treating medical professionals. + In summary, while not definitive proof, the statement does provide some level of indirect support for rebamipide being used as a treatment for o" +19364844,Rebamipide treats dry eye syndrome,1376,CONCLUSIONS: REB and DQS may be effective for the management of dry eye syndrome after PK in terms of ocular surface findings.,True,"'Does the phrase ""Rebamipide treats dry eye syndrome"" receive at least indirect support from the statement: ""CONCLUSIONS: REB and DQS may be effective for the management of dry eye syndrome after PK in terms of ocular surface findings.""?","Yes, there is indirect support for the claim that Rebamipide treats dry eye syndrome based on the provided statement. The conclusion suggests that Rebamipide (REB) and Diquafosol (DQS) may be effective for managing dry eye syndrome after photorefractive keratectomy (PK) in terms of ocular surface findings. This implies that Rebamipide could have a positive impact on dry eye syndrome symptoms, which aligns with the general idea that Rebamipide treats dry eye syndrome. However, it is essential to consider that this conclusion is derived from a specific context (after PK) and may not necessarily generalize to all cases of dry eye syndrome." +13211904,Rebamipide treats ulcerative colitis,1377,"OBJECTIVE AND DESIGN: Since rebamipide is effective for the treatment of ulcerative colitis (UC), we examined the involvement of hepatocyte growth factor (HGF) in the action of rebamipide.",True,"'Does the phrase ""Rebamipide treats ulcerative colitis"" receive at least indirect support from the statement: ""OBJECTIVE AND DESIGN: Since rebamipide is effective for the treatment of ulcerative colitis (UC), we examined the involvement of hepatocyte growth factor (HGF) in the action of rebamipide.""?","Yes, the statement does provide indirect support for the claim that rebamipide treats ulcerative colitis (UC). The objective of the study explicitly states that rebamipide is effective for UC treatment. However, it's important to note that an indirect supportive statement does not equate to definitive proof of the claim; it only suggests that there is some evidence pointing in that direction. To fully establish rebamipide as an effective treatment for UC, one must consider other factors like clinical trial results, peer-reviewed publications, and meta-analyses that evaluate its efficacy compared to other treatments or placebos." +12062800,Rebamipide treats peptic ulcer disease,1378,"Rebamipide, a gastro-protective drug, was developed in Japan for the treatment of peptic ulcer disease.",True,"'Does the phrase ""Rebamipide treats peptic ulcer disease"" receive at least indirect support from the statement: ""Rebamipide, a gastro-protective drug, was developed in Japan for the treatment of peptic ulcer disease.""?","Yes, the statement ""Rebamipide, a gastro-protective drug, was developed in Japan for the treatment of peptic ulcer disease"" does provide indirect support for the claim that ""Rebamipide treats peptic ulcer disease."" - - However, it is important to note that correlation does not imply causation; therefore, we cannot definitively conclude that methylprednisolone was solely responsible for treating granulomatosis with polyangiitis in this case based solely on this statement. Further evidence from clinical trials and studies is required to establish a direct causal relationship between methylprednisolone treatment and successful management of granulomatosis with polyangiitis." -8018847,Methylprednisolone treats Pain,1297,A comparative trial of botulinum toxin type A and methylprednisolone for the treatment of myofascial pain syndrome and pain from chronic muscle spasm.,True,Is the triple 'Methylprednisolone treats Pain' supported by the sentence: 'A comparative trial of botulinum toxin type A and methylprednisolone for the treatment of myofascial pain syndrome and pain from chronic muscle spasm.'?,"Yes, indirectly it does support that Methylprednisolone treats pain. The statement ""A comparative trial of botulinum toxin type A and methylprednisolone for the treatment of myofascial pain syndrome and pain from chronic muscle spasm"" implies that Methylprednisolone is used in a trial for treating pain (myofascial pain syndrome and pain from chronic muscle spasm). Therefore, it indirectly supports the claim that Methylprednisolone treats pain. However, it is important to note that this is an indirect inference based on the context provided in the statement and does not constitute definitive proof that Methylprednisolone is an effective treatment for all types of pain." -7905007,Methylprednisolone treats chronic progressive multiple sclerosis,1298,OBJECTIVE: To determine if there are variables linked to responsiveness to pulse cyclophosphamide/methylprednisolone therapy in progressive Multiple Sclerosis (MS).,False,Is the triple 'Methylprednisolone treats chronic progressive multiple sclerosis' supported by the sentence: 'OBJECTIVE: To determine if there are variables linked to responsiveness to pulse cyclophosphamide/methylprednisolone therapy in progressive Multiple Sclerosis (MS).'?,"No, the statement does not provide direct or indirect support for the claim that methylprednisolone treats chronic progressive multiple sclerosis (CPMS). The objective in the statement is focused on determining variables linked to responsiveness to pulse cyclophosphamide/methylprednisolone therapy in progressive MS, which is different from claiming that methylprednisolone treats CPMS. The statement is about understanding who might respond better to treatment involving methylprednisolone rather than making an assertion about its therapeutic effect on CPMS." -7853881,Methylprednisolone treats rheumatoid arthritis,1299,Oral low-dose glucocorticosteroids as compared with intravenous methylprednisolone pulses in the treatment of rheumatoid arthritis.,False,Is the triple 'Methylprednisolone treats rheumatoid arthritis' supported by the sentence: 'Oral low-dose glucocorticosteroids as compared with intravenous methylprednisolone pulses in the treatment of rheumatoid arthritis.'?,"No, the statement does not provide direct or indirect support for the phrase ""Methylprednisolone treats rheumatoid arthritis."" The study referenced in the statement is comparing oral low-dose glucocorticosteroids (a class of drugs that includes methylprednisolone) with intravenous methylprednisolone pulses in treating rheumatoid arthritis. The statement does not provide information about methylprednisolone specifically treating rheumatoid arthritis; instead, it focuses on comparing different administration methods for glucocorticosteroids in treating rheumatoid arthritis." -7827490,Methylprednisolone treats optic neuritis,1300,CONCLUSIONS: The ONTT has led to a dramatic reduction in the use of oral prednisone without a preceding course of intravenous methylprednisolone in the treatment of acute optic neuritis.,True,Is the triple 'Methylprednisolone treats optic neuritis' supported by the sentence: 'CONCLUSIONS: The ONTT has led to a dramatic reduction in the use of oral prednisone without a preceding course of intravenous methylprednisolone in the treatment of acute optic neuritis.'?,"Yes, the statement does provide indirect support for the claim that methylprednisolone treats optic neuritis. The ONTT (Optic Neuritis Treatment Trial) concluded that there was a significant reduction in oral prednisone use without first administering intravenous methylprednisolone for acute optic neuritis treatment. This suggests that intravenous methylprednisolone is an effective treatment for optic neuritis, as its use led to a reduction in oral prednisone treatment, which might imply that methylprednisolone is more efficacious in treating optic neuritis than oral prednisone alone. However, it is important to note that the statement does not offer direct evidence that methylprednisolone treats optic neuritis; it only implies its efficacy by contrasting it with another treatment method. Further investigation into clinical trials and experimental studies is necessary to establish a definitive conclusion on methylprednisolone as an effective treatment for optic neuritis." -7808987,Methylprednisolone treats autoimmune thrombocytopenic purpura,1301,CONCLUSION: A short intravenous course of high-dose methylprednisolone is effective as initial treatment of adults with ITP.,True,Is the triple 'Methylprednisolone treats autoimmune thrombocytopenic purpura' supported by the sentence: 'CONCLUSION: A short intravenous course of high-dose methylprednisolone is effective as initial treatment of adults with ITP.'?,"Yes, the statement does provide indirect support for the phrase ""Methylprednisolone treats autoimmune thrombocytopenic purpura (ITP)"". The conclusion in the statement suggests that high-dose methylprednisolone is effective as an initial treatment for adults with ITP, which is a form of autoimmune thrombocytopenic purpura. This implies that methylprednisolone has therapeutic benefits for ITP patients, thus supporting the idea that methylprednisolone treats autoimmune thrombocytopenic purpura. However, it is important to note that direct clinical application should be made under professional medical supervision considering individual patient circumstances and potential side effects." -7700869,Methylprednisolone treats Edema,1302,"Lipid peroxidation and oedema in experimental brain injury: comparison of treatment with methylprednisolone, tirilazad mesylate and vitamin E.",True,"Is the triple 'Methylprednisolone treats Edema' supported by the sentence: 'Lipid peroxidation and oedema in experimental brain injury: comparison of treatment with methylprednisolone, tirilazad mesylate and vitamin E.'?","Yes, there is indirect support for the claim that methylprednisolone treats edema based on the statement: ""Lipid peroxidation and oedema in experimental brain injury: comparison of treatment with methylprednisolone, tirilazad mesylate and vitamin E."" + The key term here is ""developed for."" In general, when a drug is developed for treating a specific condition, it implies that there is evidence suggesting that the drug can effectively manage that condition. Therefore, it can be inferred that Rebamipide has some therapeutic effect on peptic ulcer disease since it was developed for that purpose. - - The title itself mentions methylprednisolone as one of the treatments being compared in an experimental brain injury model. The term ""oedema"" is also present in the title, which is another way of referring to edema. Since methylprednisolone is being studied in relation to edema within the context of brain injury, it suggests that there is some basis for exploring its potential therapeutic benefits for treating edema. + However, it is essential to note that while this statement offers indirect evidence supporting Rebamipide's efficacy in treating peptic ulcer disease, it does not constitute definitive proof of its therapeutic benefits. For a more robust conclusion, we would need additional information such as clinical trial results demonstrating Rebamipide's efficacy in treating peptic ulcer disease compared to other treatment options or placebos. - - However, it is essential to note that indirect support does not equate to definitive proof that methylprednisolone treats edema. Further investigation is required to establish causality, dosage information, potential side effects, and overall efficacy in treating edema under various conditions. Additionally, it is crucial to consider that correlation does not imply causation; thus, while methylprednisolone may have an impact on ed" -7668594,Methylprednisolone treats multiple sclerosis,1303,The same determinations were repeated on plasma and on CSF samples that were collected after the MS patients had ended a six-day treatment with high-dose methylprednisolone (MP).,False,Is the triple 'Methylprednisolone treats multiple sclerosis' supported by the sentence: 'The same determinations were repeated on plasma and on CSF samples that were collected after the MS patients had ended a six-day treatment with high-dose methylprednisolone (MP).'?,"No, the statement does not provide direct or indirect support for the claim that ""Methylprednisolone treats multiple sclerosis."" The statement only mentions that MS patients had undergone treatment with high-dose methylprednisolone for six days and that plasma and cerebrospinal fluid (CSF) samples were collected after treatment. It does not provide any information about the outcomes or effects of the treatment on multiple sclerosis symptoms or progression. Therefore, it is not possible to infer any relationship between methylprednisolone and multiple sclerosis treatment based on this statement alone." -7649490,Methylprednisolone treats aplastic anemia,1304,"Neutropenic infections are the major cause of morbidity and mortality in the treatment of aplastic anemia (AA) with antilymphocyte globulin (ALG), cyclosporin A (CSA), and methylprednisolone (MP).",True,"Is the triple 'Methylprednisolone treats aplastic anemia' supported by the sentence: 'Neutropenic infections are the major cause of morbidity and mortality in the treatment of aplastic anemia (AA) with antilymphocyte globulin (ALG), cyclosporin A (CSA), and methylprednisolone (MP).'?","Yes, the statement does provide indirect support for the claim that methylprednisolone treats aplastic anemia. The key phrase here is ""and methylprednisolone (MP)"", which implies that methylprednisolone is part of the treatment regimen for aplastic anemia (AA). However, it does not explicitly state that methylprednisolone treats AA; rather it suggests that it is used in conjunction with other treatments (ALG and CSA) to manage complications (neutropenic infections) associated with AA treatment. Therefore, while there is some support for the claim, it is not a direct confirmation that methylprednisolone is an independent treatment for AA. + In conclusion, while there is some level of support for Rebamipide treating peptic ulcer disease based on its development for that purpose, further evidence" +10368387,Rebamipide treats gastric ulcer,1379,Rebamipide is a mucoprotective drug used for the treatment of gastric ulcers.,True,"'Does the phrase ""Rebamipide treats gastric ulcer"" receive at least indirect support from the statement: ""Rebamipide is a mucoprotective drug used for the treatment of gastric ulcers.""?","Yes, the statement ""Rebamipide is a mucoprotective drug used for the treatment of gastric ulcers"" does provide indirect support for the phrase ""Rebamipide treats gastric ulcer."" - It is important to note that medical treatments are often complex and involve multiple components, each addressing different aspects of a disease or its symptoms. Therefore, finding a drug mentioned in the context of treating a condition does not necessarily mean it is an independent treatment for that condition. It could also be part of a larger treatment regimen or used to manage complications arising from treatment." -7552935,Methylprednisolone treats Inflammation,1305,Methylprednisolone treatment resulted in the greatest reduction in the inflammatory cell infiltrate but the numbers of infected neurons did not increase concomitantly.,True,Is the triple 'Methylprednisolone treats Inflammation' supported by the sentence: 'Methylprednisolone treatment resulted in the greatest reduction in the inflammatory cell infiltrate but the numbers of infected neurons did not increase concomitantly.'?,"Yes, the statement does provide indirect support for the phrase ""Methylprednisolone treats Inflammation"". The statement suggests that methylprednisolone treatment led to a reduction in inflammatory cell infiltrate, which is an indicator of reduced inflammation. This implies that methylprednisolone has an anti-inflammatory effect, thus supporting the claim that it treats inflammation. However, it's important to note that this is an indirect inference based on one specific experimental outcome. The overall efficacy of methylprednisolone in treating inflammation would need to be evaluated across multiple studies and contexts." -7483648,Methylprednisolone treats adult acute respiratory distress syndrome,1306,Severe systemic inflammatory response syndrome with shock and ARDS resulting from Still's disease: clinical response with high-dose pulse methylprednisolone therapy.,True,Is the triple 'Methylprednisolone treats adult acute respiratory distress syndrome' supported by the sentence: 'Severe systemic inflammatory response syndrome with shock and ARDS resulting from Still's disease: clinical response with high-dose pulse methylprednisolone therapy.'?,"Yes, the statement does provide indirect support for the claim that methylprednisolone treats adult acute respiratory distress syndrome (ARDS). The statement suggests that high-dose pulse methylprednisolone therapy was effective in treating a patient with adult respiratory distress syndrome (ARDS) as part of a severe systemic inflammatory response syndrome caused by Still's disease. However, it is important to note that this is an indirect support because the primary focus of the statement is on Still's disease rather than ARDS itself. More direct evidence from randomized controlled trials would be needed for stronger support. + The key term here is ""used for the treatment,"" which implies that Rebamipide has been administered to patients with gastric ulcers as part of a therapeutic regimen. This suggests that Rebamipide does have some efficacy in treating gastric ulcers, thus lending credence to the phrase ""Rebamipide treats gastric ulcer."" - To further elaborate on my response, let me first clarify some definitions. Adult acute respiratory distress syndrome (ARDS) is characterized by widespread inflammation in the lungs that can be caused by various direct (e.g., pneumonia) or indirect (e.g., sepsis) insults leading to non-cardiogenic pulmonary edema, hypoxemia, and reduced lung compliance (Force et al., 2012). Methylprednisolone is a corticosteroid often used in clinical settings for its potent" -7432980,Methylprednisolone treats myelodysplastic syndrome,1307,Eosinophilic fasciitis associated with autoimmune thyroid disease and myelodysplasia treated with pulsed methylprednisolone and antihistamines.,True,Is the triple 'Methylprednisolone treats myelodysplastic syndrome' supported by the sentence: 'Eosinophilic fasciitis associated with autoimmune thyroid disease and myelodysplasia treated with pulsed methylprednisolone and antihistamines.'?,"Yes, indirectly it does lend some support. The statement mentions that methylprednisolone was used in treating eosinophilic fasciitis associated with myelodysplasia (a type of myelodysplastic syndrome). This implies that methylprednisolone could potentially be an effective treatment option for myelodysplastic syndrome, as suggested by the initial phrase. However, it is important to note that eosinophilic fasciitis is not equivalent to myelodysplastic syndrome; they are two distinct conditions that happened to be present in this particular case. Therefore, while there is some indirect support for the use of methylprednisolone in treating myelodysplastic syndrome based on this statement alone, further evidence would be required before making any definitive conclusions about its efficacy in treating myelodysplastic syndrome specifically." -16097513,Cefotaxime treats osteomyelitis,1308,Cefotaxime in the treatment of chronic osteomyelitis caused by gram-negative bacilli.,True,Is the triple 'Cefotaxime treats osteomyelitis' supported by the sentence: 'Cefotaxime in the treatment of chronic osteomyelitis caused by gram-negative bacilli.'?,"Yes, the statement ""Cefotaxime in the treatment of chronic osteomyelitis caused by gram-negative bacilli"" does provide indirect support for the claim that ""Cefotaxime treats osteomyelitis."" Osteomyelitis is an infection of the bone, which can be caused by various types of bacteria including gram-negative bacilli. Cefotaxime is an antibiotic known to be effective against gram-negative bacilli. Therefore, it can be inferred that Cefotaxime can treat osteomyelitis when caused by gram-negative bacilli as indicated in the statement. However, it is important to note that osteomyelitis can also be caused by gram-positive bacteria and fungi, for which Cefotaxime may not be effective." -15119078,Cefotaxime treats peritonitis,1309,Aztreonam and cefotaxime were compared in 44 cirrhotic patients who had 52 episodes of gram-negative spontaneous peritonitis.,False,Is the triple 'Cefotaxime treats peritonitis' supported by the sentence: 'Aztreonam and cefotaxime were compared in 44 cirrhotic patients who had 52 episodes of gram-negative spontaneous peritonitis.'?,"No, the phrase ""Cefotaxime treats peritonitis"" does not receive direct support from the statement: ""Aztreonam and cefotaxime were compared in 44 cirrhotic patients who had 52 episodes of gram-negative spontaneous peritonitis."" + However, it is important to note that ""treats"" is a strong verb indicating direct causality, whereas ""used for the treatment"" suggests more of an associative relationship rather than direct causality. Therefore, while there is indirect support for the claim that Rebamipide treats gastric ulcers, it would be more accurate to state that Rebamipide has been used in the treatment of gastric ulcers based on current evidence. - The statement only indicates that cefotaxime was part of a comparative study involving patients with gram-negative spontaneous peritonitis. It does not explicitly state that cefotaxime treats peritonitis nor provide information on its efficacy compared to other treatments. To make a claim about cefotaxime treating peritonitis, there would need to be evidence demonstrating its causative relationship in treating peritonitis, which is not provided in this statement." -11176033,Cefotaxime treats Sepsis,1310,"Due to the apparent volumes of distribution obtained (ranging from 0.48 to 0.51 L/kg), considering the overall clinical efficacy obtained (90% for the 10 mg/kg dose and 75% for the 20 mg/kg dose), and due to the rapid improvement observed after a few doses of the drug (1.8 to 2.5 doses to 'clinical improvement'), it is safe to postulate such doses of cefotaxime as excellent choices for the treatment of septicaemia in dogs.",True,"Is the triple 'Cefotaxime treats Sepsis' supported by the sentence: 'Due to the apparent volumes of distribution obtained (ranging from 0.48 to 0.51 L/kg), considering the overall clinical efficacy obtained (90% for the 10 mg/kg dose and 75% for the 20 mg/kg dose), and due to the rapid improvement observed after a few doses of the drug (1.8 to 2.5 doses to 'clinical improvement'), it is safe to postulate such doses of cefotaxime as excellent choices for the treatment of septicaemia in dogs.'?","Yes, indirect support can be inferred from the statement for the phrase ""Cefotaxime treats Sepsis"" in dogs. The statement provides evidence that Cefotaxime has been observed to have clinical efficacy in treating septicaemia (a synonym for sepsis) in dogs, with 90% success rate for 10 mg/kg dose and 75% for 20 mg/kg dose. Additionally, rapid improvement was observed after a few doses (1.8-2.5), which suggests the effectiveness of the treatment. However, it is important to note that while there is support for Cefotaxime as an effective treatment for sepsis in dogs, the statement does not explicitly confirm that Cefotaxime treats sepsis; therefore, the support is indirect. + This interpretation highlights one of the nuances in interpreting scientific evidence - the language used can significantly impact how" +8102739,Rebamipide treats gastritis,1380,"In conclusion, rebamipide may attenuate H. pylori-induced gastric inflammation by inhibiting lipid peroxidation and oxidant-mediated activation of NF-kappaB and thereby decreasing IL-8 production.",True,"'Does the phrase ""Rebamipide treats gastritis"" receive at least indirect support from the statement: ""In conclusion, rebamipide may attenuate H. pylori-induced gastric inflammation by inhibiting lipid peroxidation and oxidant-mediated activation of NF-kappaB and thereby decreasing IL-8 production.""?","Yes, the statement does provide indirect support for the claim that rebamipide treats gastritis. The conclusion suggests that rebamipide may attenuate H. pylori-induced gastric inflammation by inhibiting lipid peroxidation and oxidant-mediated activation of NF-kappaB, which in turn decreases IL-8 production. Gastritis is an inflammation of the stomach lining often caused by H. pylori infection. By reducing inflammation, rebamipide could potentially alleviate symptoms of gastritis, providing a basis for the claim that it treats gastritis. However, it is important to note that direct clinical evidence of rebamipide's efficacy in treating gastritis would strengthen this claim." +27610972,DINUTUXIMAB treats bone osteosarcoma,1381,Phase I trial of a human-mouse chimeric anti-disialoganglioside monoclonal antibody ch14.18 in patients with refractory neuroblastoma and osteosarcoma.,False,"'Does the phrase ""DINUTUXIMAB treats bone osteosarcoma"" receive at least indirect support from the statement: ""Phase I trial of a human-mouse chimeric anti-disialoganglioside monoclonal antibody ch14.18 in patients with refractory neuroblastoma and osteosarcoma.""?","No, the statement does not provide indirect support for the phrase ""DINUTUXIMAB treats bone osteosarcoma"". The study mentioned in the statement is a Phase I trial of a human-mouse chimeric anti-disialoganglioside monoclonal antibody (ch14.18) in patients with refractory neuroblastoma and osteosarcoma. Dinutuximab is also a human-mouse chimeric monoclonal antibody that targets the same antigen (disialoganglioside GD2) as ch14.18. However, the study does not specify that dinutuximab was used in the trial, nor does it provide any outcomes specifically related to osteosarcoma treatment. Therefore, it does not offer any evidence that dinutuximab is effective in treating bone osteosarcoma." +21740095,DINUTUXIMAB treats neoplasm,1382,Tumors treated with local dinutuximab had decreased MYCN expression on histology compared to control or IgG-treated tumors.,True,"'Does the phrase ""DINUTUXIMAB treats neoplasm"" receive at least indirect support from the statement: ""Tumors treated with local dinutuximab had decreased MYCN expression on histology compared to control or IgG-treated tumors.""?","Yes, indirectly it does lend some support. The statement suggests that dinutuximab has an effect on tumors by decreasing MYCN expression as observed through histology. This implies that dinutuximab could potentially be used as a treatment for neoplasms (a type of new abnormal growth of cells, also known as tumors). However, it's important to note that this is an indirect inference based on one specific observation. A more definitive conclusion would require additional evidence demonstrating that dinutuximab treatment leads to reduced tumor growth or improved patient outcomes in clinical settings." +9445080,DINUTUXIMAB treats neuroblastoma,1383,Ocular symptoms in children treated with human-mouse chimeric anti-GD2 mAb ch14.18 for neuroblastoma.,False,"'Does the phrase ""DINUTUXIMAB treats neuroblastoma"" receive at least indirect support from the statement: ""Ocular symptoms in children treated with human-mouse chimeric anti-GD2 mAb ch14.18 for neuroblastoma.""?","No, the statement does not provide indirect support for the claim that Dinutuximab treats neuroblastoma. - The statement does not provide information about other potential treatments for sepsis in dogs, so no comparison can be made regarding Cefotaxime being superior or inferior to other treatments. Additionally, further studies would be required to confirm these results and ensure there are no adverse effects associated with" -8153267,Cefotaxime treats bacterial infectious disease,1311,These results suggest that amoxicillin-clavulanic acid is an effective alternative to cefotaxime for the empirical treatment of bacterial infections in cirrhosis.,False,Is the triple 'Cefotaxime treats bacterial infectious disease' supported by the sentence: 'These results suggest that amoxicillin-clavulanic acid is an effective alternative to cefotaxime for the empirical treatment of bacterial infections in cirrhosis.'?,"No, the statement does not provide direct or indirect support for the phrase ""Cefotaxime treats bacterial infectious disease"". The provided statement discusses an alternative treatment option (amoxicillin-clavulanic acid) to cefotaxime in specific circumstances (empirical treatment of bacterial infections in cirrhosis). This does not imply that cefotaxime is ineffective for treating bacterial infections but rather suggests that there might be an alternative option in certain situations." -26980543,Ceftriaxone treats Lyme disease,1312,"Most children had received prolonged and repeated courses of oral antimicrobials and/or home intravenous infusion of antimicrobials; 79% had been hospitalized for treatment of suspected LD or management of treatment complications, most notably drug-induced symptoms of gallbladder disease occurring in patients receiving ceftriaxone (Rocephin), and bloodstream infections associated with intravenous catheters.",False,"Is the triple 'Ceftriaxone treats Lyme disease' supported by the sentence: 'Most children had received prolonged and repeated courses of oral antimicrobials and/or home intravenous infusion of antimicrobials; 79% had been hospitalized for treatment of suspected LD or management of treatment complications, most notably drug-induced symptoms of gallbladder disease occurring in patients receiving ceftriaxone (Rocephin), and bloodstream infections associated with intravenous catheters.'?","No, the statement does not provide indirect support for the claim that Ceftriaxone treats Lyme disease (LD). The passage discusses the treatment complications experienced by children receiving Ceftriaxone (Rocephin) for suspected LD. The fact that many children were treated with Ceftriaxone does not imply that it is an effective treatment for Lyme disease; instead, it highlights the severity of complications arising from its use in these patients. + Dinutuximab is a monoclonal antibody that targets GD2 (disialoganglioside), which is overexpressed in neuroblastoma cells. It is also known as ch14.18, so the human-mouse chimeric anti-GD2 mAb ch14.18 mentioned in the statement refers to Dinutuximab itself. - To provide indirect support for the claim that Ceftriaxone treats Lyme disease, one would need evidence suggesting that patients improved upon receiving Ceftriaxone specifically for Lyme disease, not as a result of other treatments or interventions. The passage does not contain information about patients' responses to treatment; therefore, it cannot support the claim in question." -26401802,Ceftriaxone treats Sepsis,1313,"Clinical study of Rocephin, a 3d generation cephalosporin, in various septicaemias.",True,"Is the triple 'Ceftriaxone treats Sepsis' supported by the sentence: 'Clinical study of Rocephin, a 3d generation cephalosporin, in various septicaemias.'?","Yes, indirectly it does lend support. Rocephin is another name for Ceftriaxone, which is a third-generation cephalosporin antibiotic. The statement indicates that Rocephin has been studied in various septicaemias (a synonym for sepsis). Therefore, it can be inferred that Ceftriaxone has been investigated for its effectiveness in treating sepsis, even though the phrase ""Ceftriaxone treats Sepsis"" is not explicitly stated in the provided context. However, it is important to note that while this statement suggests Ceftriaxone may be used to treat sepsis, it does not provide direct evidence of its efficacy in such cases. Further investigation into clinical trial results and literature would be necessary for a more definitive conclusion on its therapeutic value in sepsis treatment." -18413392,Ceftriaxone treats bacterial pneumonia,1314,"The objectives of this open, prospective, randomized and comparative study were to evaluate and compare the efficacy and safety of intravenous ceftriaxone (active ingredient of Rocephin) and cefotaxime in treatment of bacterial pneumoniae.",True,"Is the triple 'Ceftriaxone treats bacterial pneumonia' supported by the sentence: 'The objectives of this open, prospective, randomized and comparative study were to evaluate and compare the efficacy and safety of intravenous ceftriaxone (active ingredient of Rocephin) and cefotaxime in treatment of bacterial pneumoniae.'?","Yes, the statement does provide indirect support for the phrase ""Ceftriaxone treats bacterial pneumonia."" The study mentioned in the statement is designed to evaluate and compare the efficacy and safety of intravenous ceftriaxone (an active ingredient in Rocephin) and cefotaxime in treating bacterial pneumoniae. This implies that ceftriaxone is being considered as a potential treatment for bacterial pneumonia, thereby lending indirect support to the claim that ceftriaxone can be used to treat bacterial pneumonia. However, it is important to note that actual evidence of ceftriaxone's efficacy in treating bacterial pneumonia would require further examination of the study results themselves, as the statement only describes the study objectives and does not provide any information on the outcomes or conclusions drawn from the study." -25810060,Gefarnate treats gastric ulcer,1315,Clinical trial of Gefarnate in the treatment of gastric ulcer disease.,True,Is the triple 'Gefarnate treats gastric ulcer' supported by the sentence: 'Clinical trial of Gefarnate in the treatment of gastric ulcer disease.'?,"Yes, the phrase ""Gefarnate treats gastric ulcer"" does receive indirect support from the statement: ""Clinical trial of Gefarnate in the treatment of gastric ulcer disease."" + The statement discusses ocular symptoms in children treated with Dinutuximab for neuroblastoma. While it indicates that Dinutuximab is used in treating neuroblastoma patients, it does not provide any information about the treatment efficacy (e.g., response rates, overall survival) in these patients. Therefore, it fails to support the claim that Dinutuximab treats neuroblastoma indirectly. - The reason for my affirmative response is that conducting a clinical trial implies that there is some degree of belief that the drug being tested (in this case, Gefarnate) has potential therapeutic benefits for the condition under investigation (gastric ulcer disease). A clinical trial typically involves rigorous testing and evaluation procedures that aim to establish whether a treatment is both safe and effective for its intended use. + To provide indirect support for the claim that Dinutuximab treats neuroblastoma, one would need evidence showing that patients treated with Dinutuximab have better outcomes (e.g., reduced tumor burden, improved overall survival)" +22808973,BRENTUXIMAB VEDOTIN treats anaplastic large cell lymphoma,1384,[Brentuximab vedotin for previously untreated systemic anaplastic large cell lymphoma].,True,"'Does the phrase ""BRENTUXIMAB VEDOTIN treats anaplastic large cell lymphoma"" receive at least indirect support from the statement: ""[Brentuximab vedotin for previously untreated systemic anaplastic large cell lymphoma].""?","Yes, the phrase ""Brentuximab vedotin treats anaplastic large cell lymphoma"" does receive indirect support from the statement: ""[Brentuximab vedotin for previously untreated systemic anaplastic large cell lymphoma]."" - Therefore, even though the statement does not explicitly confirm that Gefarnate successfully treats gastric ulcers, it does provide evidence that researchers have investigated its potential in that context. This investigation lends credibility to the claim that Gefarnate may indeed have some positive impact on gastric ulcers, even if further studies are needed for definitive proof. + The statement suggests that Brentuximab vedotin is used in treating systemic anaplastic large cell lymphoma (sALCL), which is a specific type of anaplastic large cell lymphoma (ALCL). ALCL is a peripheral T-cell lymphoma (PTCL), which is a group of aggressive non-Hodgkin lymphomas (NHL). Brentuximab vedotin is an antibody-drug conjugate that targets CD30, which is often expressed in ALCL cells. - Nonetheless, it is crucial to note that no definitive conclusions can be drawn without access to more detailed information about the clinical trial itself (such as its design, sample size, results, etc.). Ultimately, any claim regarding Gefarn" -25784688,Gefarnate treats duodenal ulcer,1316,[Clinicobiological evolution of duodenal ulcer treated with gefarnate].,True,Is the triple 'Gefarnate treats duodenal ulcer' supported by the sentence: '[Clinicobiological evolution of duodenal ulcer treated with gefarnate].'?,"Yes, the phrase ""Gefarnate treats duodenal ulcer"" does receive indirect support from the statement: ""[Clinicobiological evolution of duodenal ulcer treated with gefarnate]."" + Although the statement does not explicitly claim that Brentuximab vedotin treats anaplastic large cell lymphoma, it implies that Brentuximab vedotin is used in treating sALCL patients who have not received prior systemic therapy. This indirectly supports the idea that Brentuxim" +22284390,BRENTUXIMAB VEDOTIN treats neoplasm,1385,"Although brentuximab-vedotin (BV) demonstrated single-agent activity, tumours regrew during BV therapy.",False,"'Does the phrase ""BRENTUXIMAB VEDOTIN treats neoplasm"" receive at least indirect support from the statement: ""Although brentuximab-vedotin (BV) demonstrated single-agent activity, tumours regrew during BV therapy.""?","No, the statement ""Although brentuximab-vedotin (BV) demonstrated single-agent activity, tumours regrew during BV therapy"" does not provide indirect support for the phrase ""BRENTUXIMAB VEDOTIN treats neoplasm."" The statement indicates that BV has shown some effectiveness as a single agent in treating neoplasm (cancerous growths), but it also reveals that tumours can regrow during BV therapy. This suggests that BV may not necessarily cure neoplasm but may only temporarily halt its progression in some cases. The ability of BV to treat neoplasm is not supported by this statement alone since treating implies durable therapeutic success that prevents disease recurrence in patients. - The title suggests that gefarnate is used in treating duodenal ulcers by implying causality between gefarnate administration and changes in duodenal ulcers over time (i.e., clinicobiological evolution). However, it is essential to note that direct causality cannot be definitively concluded without further information about the study design, results, and statistical analysis provided in the study itself. + To provide indirect support for ""BRENTUXIMAB VEDOTIN treats neoplasm,"" we would need evidence suggesting that BV leads to long-term tumour control or elimination in patients, rather than just temporary regression. For example, clinical trial results demonstrating improved survival rates in patients treated with BV compared to those who did not receive BV would offer indirect support for BV treating neoplasm. - Nonetheless, based on the title alone, one can infer that gefarnate is being associated with treating duodenal ulcers in some capacity, providing indirect support for that claim." -19702373,Gefarnate treats peptic ulcer disease,1317,"One hundred and thirty-nine patients with endoscopically confirmed peptic ulcers (gastric and duodenal) entered a double blind comparative evaluation of alprazolam (1.2 mg/day), gefarnate (300 mg/day) and their combination in treatment of peptic ulcer.",True,"Is the triple 'Gefarnate treats peptic ulcer disease' supported by the sentence: 'One hundred and thirty-nine patients with endoscopically confirmed peptic ulcers (gastric and duodenal) entered a double blind comparative evaluation of alprazolam (1.2 mg/day), gefarnate (300 mg/day) and their combination in treatment of peptic ulcer.'?","Yes, the statement does provide indirect support for the claim that gefarnate treats peptic ulcer disease. The reason is that it mentions gefarnate (300 mg/day) being used in a double-blind comparative evaluation for treating peptic ulcers (gastric and duodenal). This implies that there is an interest in studying gefarnate as a potential treatment for peptic ulcers in a clinical setting. + In summary, while B" +21657991,BRENTUXIMAB VEDOTIN treats mature T-cell and NK-cell non-Hodgkin lymphoma,1386,BV is a major therapeutic advance in the treatment of patients with R/R CTCL and of those with PTCL in both the R/R and frontline settings.,True,"'Does the phrase ""BRENTUXIMAB VEDOTIN treats mature T-cell and NK-cell non-Hodgkin lymphoma"" receive at least indirect support from the statement: ""BV is a major therapeutic advance in the treatment of patients with R/R CTCL and of those with PTCL in both the R/R and frontline settings.""?","Yes, there is indirect support for the statement that ""BRENTUXIMAB VEDOTIN treats mature T-cell and NK-cell non-Hodgkin lymphoma"" based on the provided statement. - However, it is important to note that indirect support does not equate to definitive evidence that gefarnate is an effective treatment for peptic ulcer disease. The statement does not include information on the outcomes of the study, such as whether patients in the gefarnate group showed significant improvement compared to those in other groups (alprazolam and combination). Additionally, further factors such as side effects, long-term effects, and comparative efficacy should be taken into account before making any conclusions about gefarnate as an appropriate treatment for peptic ulcer disease." -22023951,Regadenoson treats coronary artery disorder,1318,CONCLUSIONS: Regadenoson may be a safe vasodilator for CTP and MR MPI in CAD patients.,True,Is the triple 'Regadenoson treats coronary artery disorder' supported by the sentence: 'CONCLUSIONS: Regadenoson may be a safe vasodilator for CTP and MR MPI in CAD patients.'?,"Yes, there is indirect support for the phrase ""Regadenoson treats coronary artery disorder"" in the statement ""CONCLUSIONS: Regadenoson may be a safe vasodilator for CTP (Computed Tomography Perfusion) and MR MPI (Myocardial Perfusion Imaging) in CAD (Coronary Artery Disease) patients."" + BRENTUXIMAB VEDOTIN (BV) is mentioned as a major therapeutic advance in treating patients with R/R Cutaneous T-cell Lymphoma (CTCL) and patients with Peripheral T-cell Lymphoma (PTCL) in both relapsed/refractory (R/R) and frontline settings. Both CTCL and PTCL are subtypes of non-Hodgkin lymphoma (NHL), which primarily involve mature T-cells (CTCL) and NK-cells (a subset of T-cells) in their pathogenesis. Therefore, by treating CTCL and PTCL, BV indeed treats mature T-cell and NK-cell NHL subtypes as asserted in the original statement. - Justification: + However, it is important to note that BV may not be effective against all NHL subtypes involving mature T-cells and NK-cells" +21657990,BRENTUXIMAB VEDOTIN treats primary cutaneous T-cell non-Hodgkin lymphoma,1387,BV is a major therapeutic advance in the treatment of patients with R/R CTCL and of those with PTCL in both the R/R and frontline settings.,True,"'Does the phrase ""BRENTUXIMAB VEDOTIN treats primary cutaneous T-cell non-Hodgkin lymphoma"" receive at least indirect support from the statement: ""BV is a major therapeutic advance in the treatment of patients with R/R CTCL and of those with PTCL in both the R/R and frontline settings.""?","Yes, the statement does provide indirect support for the claim that BRENTUXIMAB VEDOTIN treats primary cutaneous T-cell non-Hodgkin lymphoma (PTCL). The statement highlights that BRENTUXIMAB VEDOTIN (BV) is a significant advancement in treating patients with relapsed/refractory (R/R) cutaneous T-cell lymphoma (CTCL) and frontline PTCL settings. Since primary cutaneous T-cell non-Hodgkin lymphoma is a subtype of CTCL, it implies that BV could be an effective treatment option for primary cutaneous T-cell non-Hodgkin lymphoma patients as well, particularly in relapsed/refractory cases due to its therapeutic advancements in R/R CTCL treatment. However, it is crucial to note that direct clinical trial results specifically investigating BV in primary cutaneous T-cell non-Hodgkin lymphoma patients would provide stronger support for the claim." +21596847,BRENTUXIMAB VEDOTIN treats Sezary syndrome,1388,"[Ulceration of lymphomatous skin lesions in a patient with Sezary syndrome treated with brentuximab-vedotin].BACKGROUND: Brentuximab-vedotin (BV), an anti-CD30 agent combined with an anti-neoplastic agent, has recently yielded promising results in the treatment of cutaneous T-lymphomas such as Sezary syndrome.",True,"'Does the phrase ""BRENTUXIMAB VEDOTIN treats Sezary syndrome"" receive at least indirect support from the statement: ""[Ulceration of lymphomatous skin lesions in a patient with Sezary syndrome treated with brentuximab-vedotin].BACKGROUND: Brentuximab-vedotin (BV), an anti-CD30 agent combined with an anti-neoplastic agent, has recently yielded promising results in the treatment of cutaneous T-lymphomas such as Sezary syndrome.""?","Yes, indirect support can be inferred from the statement provided. The background information indicates that Brentuximab-vedotin (BV) has shown promising results in treating cutaneous T-cell lymphomas like Sezary syndrome. The statement specifically mentions a patient with Sezary syndrome being treated with BV, but it does not explicitly mention whether ulceration of lymphomatous skin lesions improved as a result of treatment. - Regadenoson is mentioned as a safe vasodilator in the context of CTP and MR MPI for CAD patients. A vasodilator is a substance that widens blood vessels, improving blood flow, which is crucial in treating coronary artery disorders like CAD. Therefore, if Regadenoson safely dilates coronary arteries during imaging procedures like CTP and MR MPI for CAD patients, it indirectly supports the claim that Regadenoson treats coronary artery disorders. + + However, since BV is known for its therapeutic effects on cutaneous T-cell lymphomas such as Sezary syndrome, it is reasonable to infer that treating such patients might lead to improvements in skin lesions over time. As such, ulceration of lymphomatous skin lesions could be among those improvements indirectly supported by the statement in question. - However, it is essential to emphasize that while there is indirect support for Regadenoson treating coronary artery disorders based on its use as a safe vasodilator in CAD patients during imaging procedures, further investigation is necessary for more" -13297277,Meldonium treats Ischemic stroke,1319,A study is presented of the clinico-hemodynamic efficacy of mildronate in 38 patients with ischemic stroke.,False,Is the triple 'Meldonium treats Ischemic stroke' supported by the sentence: 'A study is presented of the clinico-hemodynamic efficacy of mildronate in 38 patients with ischemic stroke.'?,"No, the statement ""A study is presented of the clinico-hemodynamic efficacy of mildronate in 38 patients with ischemic stroke"" does not provide indirect support for the claim that ""Meldonium treats Ischemic stroke."" Meldonium is often marketed under the tradename mildronate; however, the study does not explicitly state that Meldonium (Meldonium being the active ingredient) is responsible for any observed clinico-hemodynamic efficacy in patients suffering from ischemic stroke. + + Nonetheless, it is crucial to note that definitive conclusions cannot be drawn without explicit information on how skin lesions changed following BV treatment in that particular patient described in the statement." +21569598,BRENTUXIMAB VEDOTIN treats adult T-cell leukemia/lymphoma,1389,Further investigations on the use of brentuximab vedotin for adult T-cell leukemia/lymphoma are needed.,False,"'Does the phrase ""BRENTUXIMAB VEDOTIN treats adult T-cell leukemia/lymphoma"" receive at least indirect support from the statement: ""Further investigations on the use of brentuximab vedotin for adult T-cell leukemia/lymphoma are needed.""?","No, indirect support cannot be inferred from this statement alone. The statement ""Further investigations on the use of brentuximab vedotin for adult T-cell leukemia/lymphoma are needed"" implies that there is currently insufficient evidence to conclusively support or refute its use for treating adult T-cell leukemia/lymphoma. This suggests that while brentuximab vedotin may hold promise for treating adult T-cell leukemia/lymphoma, more rigorous studies would need to be conducted before making definitive conclusions about its efficacy for treating such conditions." +21569593,BRENTUXIMAB VEDOTIN treats lymphoma,1390,Brentuximab vedotin represents a major breakthrough in the treatment of CD30-positive lymphomas.,True,"'Does the phrase ""BRENTUXIMAB VEDOTIN treats lymphoma"" receive at least indirect support from the statement: ""Brentuximab vedotin represents a major breakthrough in the treatment of CD30-positive lymphomas.""?","Yes, the phrase ""Brentuximab vedotin treats lymphoma"" does receive indirect support from the statement: ""Brentuximab vedotin represents a major breakthrough in the treatment of CD30-positive lymphomas."" - To provide indirect support for the claim that ""Meldonium treats Ischemic stroke,"" additional information would be required linking Meldonium specifically (not merely mildronate as a tradename) to any observed benefits in patients suffering from ischemic stroke. This could be achieved through further analysis of the study in question (for example, checking if Meldonium is mentioned as an active ingredient in the treatment), looking at other relevant studies, or consulting expert opinions in the field. + The key term here is ""breakthrough in treatment."" A breakthrough implies that a significant advancement has been made in treating a particular condition - in this case, CD30-positive lymphomas. Brentuximab vedotin is an antineoplastic agent, meaning it is used to treat cancerous growths such as lymphomas. Therefore, if Brentuximab vedotin is a breakthrough in treating CD30-positive lymphomas, it follows that it must effectively treat these types of lymphomas, thus providing indirect support for the claim that ""Brentuximab vedotin treats lymphoma."" - In summary, while it is possible that Meldonium may have beneficial effects for patients suffering from ischemic stroke based on this" -25624167,Neobiotic treats pneumonia,1320,Use of neomycin for treatment of Rhodococcus equi pneumonia in foals.,True,Is the triple 'Neobiotic treats pneumonia' supported by the sentence: 'Use of neomycin for treatment of Rhodococcus equi pneumonia in foals.'?,"Yes, indirectly it does lend some support. The statement suggests that neomycin is used in treating pneumonia caused by Rhodococcus equi in foals. However, this does not necessarily mean that neobiotic (which is a class of antibiotics including neomycin) as a whole treats pneumonia, but it does imply that neomycin, as part of the neobiotic class, has been used effectively for such treatment. Therefore, while not direct evidence, it does provide some indirect support for the claim that ""Neobiotic treats pneumonia""." -11022701,Neobiotic treats bacterial infectious disease with sepsis,1321,Osteomyelitis of the cervical vertebras as a complication of urinary tract disease; Proteus bacteremia treated with neomycin.,True,Is the triple 'Neobiotic treats bacterial infectious disease with sepsis' supported by the sentence: 'Osteomyelitis of the cervical vertebras as a complication of urinary tract disease; Proteus bacteremia treated with neomycin.'?,"Yes, indirectly it does support that statement because Neobiotic is an antibiotic (neomycin in this case) which is used to treat bacterial infections. Sepsis is a serious complication of bacterial infection that can occur when an overwhelming immune response triggered by an infection injures tissues and organs throughout the body. In the provided context, Proteus bacteremia (bacteria in the blood) was treated with neomycin, which suggests that Neobiotic could be used for treating bacterial infectious diseases associated with sepsis as well. However, it is important to note that direct evidence for Neobiotic treating sepsis is not provided in this statement; hence it is an indirect inference based on the known properties and uses of neomycin as an antibiotic." -24398401,BLINATUMOMAB treats B-cell chronic lymphocytic leukemia,1322,Lineage Conversion in Pediatric B-Cell Precursor Acute Leukemia under Blinatumomab Therapy.,False,Is the triple 'BLINATUMOMAB treats B-cell chronic lymphocytic leukemia' supported by the sentence: 'Lineage Conversion in Pediatric B-Cell Precursor Acute Leukemia under Blinatumomab Therapy.'?,"No, the phrase ""BLINATUMOMAB treats B-cell chronic lymphocytic leukemia"" does not receive indirect support from the statement: ""Lineage Conversion in Pediatric B-Cell Precursor Acute Leukemia under Blinatumomab Therapy."" The statement only suggests that Blinatumomab may induce lineage conversion in pediatric B-cell precursor acute leukemia, which is different from chronic lymphocytic leukemia (B-CLL). + However, it is important to note that while Brentuximab vedotin is indeed effective for treating certain types of lymphomas (specifically those that express CD30), it may not be effective for all lymphomas" +21525451,BRENTUXIMAB VEDOTIN treats Hodgkins lymphoma,1391,"Currently, ADCs that have received regulatory approval include brentuximab vedotin for CD30-positive Hodgkin lymphoma and trastuzumab emtansine for human epidermal growth factor receptor 2-positive breast cancer.",True,"'Does the phrase ""BRENTUXIMAB VEDOTIN treats Hodgkins lymphoma"" receive at least indirect support from the statement: ""Currently, ADCs that have received regulatory approval include brentuximab vedotin for CD30-positive Hodgkin lymphoma and trastuzumab emtansine for human epidermal growth factor receptor 2-positive breast cancer.""?","Yes, the phrase ""BRENTUXIMAB VEDOTIN treats Hodgkin lymphoma"" does receive indirect support from the statement provided. - B-cell chronic lymphocytic leukemia (B-CLL) is a distinct type of leukemia that typically affects older adults, whereas acute lymphoblastic leukemia (ALL) is more common in children. Blinatumomab is an immunotherapy drug designed to target CD19-positive cells in leukemia; however, its effectiveness is mainly studied in treating acute lymphoblastic leukemia (ALL) rather than chronic lymphocytic leukemia (B-CLL). + The statement indicates that BRENTUXIMAB VEDOTIN has received regulatory approval for treating CD30-positive Hodgkin lymphoma (HL). This implies that BRENTUXIMAB VEDOTIN is an effective treatment for HL patients whose tumors express CD30 antigen. The drug is an antibody-drug conjugate (ADC) designed to deliver chemotherapy specifically to CD30-expressing cancer cells upon binding, thereby reducing systemic toxicity compared to traditional chemotherapy regimens. - Therefore" -23073290,BLINATUMOMAB treats Precursor B-Cell Lymphoblastic Leukemia-Lymphoma,1323,"We report on the Australian experience of blinatumomab for treatment of 24 children with relapsed/refractory precursor B-cell acute lymphoblastic leukaemia (B-ALL) and high-risk genetics, resulting in a minimal residual disease (MRD) response rate of 58%, 2-year progression-free survival (PFS) of 39% and 2-year overall survival of 63%.",True,"Is the triple 'BLINATUMOMAB treats Precursor B-Cell Lymphoblastic Leukemia-Lymphoma' supported by the sentence: 'We report on the Australian experience of blinatumomab for treatment of 24 children with relapsed/refractory precursor B-cell acute lymphoblastic leukaemia (B-ALL) and high-risk genetics, resulting in a minimal residual disease (MRD) response rate of 58%, 2-year progression-free survival (PFS) of 39% and 2-year overall survival of 63%.'?","Yes, the statement does provide indirect support for the claim that blinatumomab treats Precursor B-Cell Lymphoblastic Leukemia-Lymphoma (B-ALL). The report details a study conducted on 24 children with relapsed/refractory B-ALL and high-risk genetics who were treated with blinatumomab. The results showed that 58% of these patients achieved minimal residual disease (MRD) response, and 2-year progression-free survival (PFS) and overall survival were 39% and 63%, respectively. These positive outcomes suggest that blinatumomab has been effective in treating these patients with B-ALL, providing evidence for its utility in managing this type of cancer. However, it is important to note that this evidence is derived from an observational study in a specific population; further investigation through randomized controlled trials is necessary to establish more robust evidence for blinatumomab's efficacy in treating B-ALL." -21932754,BLINATUMOMAB treats acute lymphoblastic leukemia,1324,"Blinatumomab for Acute Lymphoblastic Leukemia: The First Bispecific T-Cell Engager Antibody to Be Approved by the EMA for Minimal Residual Disease.On November 15, 2018, the Committee for Medicinal Products for Human Use (CHMP) recommended the extension of indication for blinatumomab to include the treatment of adults with minimal residual disease (MRD) positive B-cell precursor acute lymphoblastic leukemia (ALL).",True,"Is the triple 'BLINATUMOMAB treats acute lymphoblastic leukemia' supported by the sentence: 'Blinatumomab for Acute Lymphoblastic Leukemia: The First Bispecific T-Cell Engager Antibody to Be Approved by the EMA for Minimal Residual Disease.On November 15, 2018, the Committee for Medicinal Products for Human Use (CHMP) recommended the extension of indication for blinatumomab to include the treatment of adults with minimal residual disease (MRD) positive B-cell precursor acute lymphoblastic leukemia (ALL).'?","Yes, the statement does provide indirect support for the claim that Blinatumomab treats acute lymphoblastic leukemia (ALL). The statement indicates that Blinatumomab has been approved by the European Medicines Agency (EMA) for the treatment of adults with minimal residual disease (MRD) positive B-cell precursor acute lymphoblastic leukemia (ALL). This suggests that Blinatumomab is an effective treatment for ALL, particularly in cases where minimal residual disease is present. However, it is important to note that this is an indirect inference, as the statement does not explicitly state that Blinatumomab treats ALL, but rather that it is approved for use in treating ALL patients with MRD." -21720587,BLINATUMOMAB treats lymphoma,1325,"Cytokine storm was reported in four patients (19%).In conclusion, treatment with blinatumomab is effective and tolerable in adult patients with relapsed/refractory B-ALL outside of a clinical trial stetting.",True,"Is the triple 'BLINATUMOMAB treats lymphoma' supported by the sentence: 'Cytokine storm was reported in four patients (19%).In conclusion, treatment with blinatumomab is effective and tolerable in adult patients with relapsed/refractory B-ALL outside of a clinical trial stetting.'?","Yes, indirectly it does lend support. The statement mentions that treatment with blinatumomab is effective and tolerable in adult patients with relapsed/refractory B-ALL outside of a clinical trial setting, which implies that blinatumomab has therapeutic effects against B-ALL, a type of lymphoma. However, direct support would require a specific mention of blinatumomab treating lymphoma. Nevertheless, given that B-ALL is a type of lymphoma, it can be inferred that blinatumomab treats lymphoma indirectly." -9387116,Ciprofloxacin physically interacts with DNA Gyrase,1326,"UNLABELLED: Ciprofloxacin, a quinolone antibiotic drug, binds to DNA topoisomerase IV and DNA gyrase of various bacteria.",True,"Is the triple 'Ciprofloxacin physically interacts with DNA Gyrase' supported by the sentence: 'UNLABELLED: Ciprofloxacin, a quinolone antibiotic drug, binds to DNA topoisomerase IV and DNA gyrase of various bacteria.'?","Yes, the phrase ""Ciprofloxacin physically interacts with DNA Gyrase"" does receive indirect support from the statement: ""UNLABELLED: Ciprofloxacin, a quinolone antibiotic drug, binds to DNA topoisomerase IV and DNA gyrase of various bacteria."" + The U.S. Food and Drug Administration (FDA) has approved BRENTUXIMAB VEDOTIN based on clinical trials demonstrating its efficacy in treating HL patients [1]. It is essential to acknowledge that while BRENTUXIMAB VEDOTIN is an effective treatment for Hodgkin lymphoma patients whose tumors express CD30 antigen, it may not be an appropriate treatment option for all HL patients due to" +21472937,BRENTUXIMAB VEDOTIN treats mycosis fungoides,1392,The interest of BV in the management of CD30-positive mycosis fungoides (MF) and primary cutaneous anaplastic large cell lymphoma has recently been demonstrated compared to methotrexate or bexarotene.,True,"'Does the phrase ""BRENTUXIMAB VEDOTIN treats mycosis fungoides"" receive at least indirect support from the statement: ""The interest of BV in the management of CD30-positive mycosis fungoides (MF) and primary cutaneous anaplastic large cell lymphoma has recently been demonstrated compared to methotrexate or bexarotene.""?","Yes, the phrase ""BRENTUXIMAB VEDOTIN treats mycosis fungoides"" does receive indirect support from the statement provided. - - The statement indicates that Ciprofloxacin binds to DNA gyrase in various bacteria. The term ""binds"" implies some form of physical interaction between Ciprofloxacin and DNA gyrase. Although the statement does not explicitly mention ""physical interaction,"" it can be inferred that such an interaction occurs based on the information provided. + The statement suggests that BRENTUXIMAB VEDOTIN (BV) has demonstrated interest in managing CD30-positive mycosis fungoides (MF) and primary cutaneous anaplastic large cell lymphoma. Mycosis fungoides is a type of cutaneous T-cell lymphoma that is often CD30-positive, meaning that BV, which targets CD30-positive cells, could be an effective treatment for it. However, the statement only implies efficacy compared to methotrexate or bexarotene, not that it is the sole treatment for MF. Therefore, while the statement does provide indirect support for BV treating MF, it does not necessarily exclude other treatment options." +22346012,Tetracycline treats Infection,1393,"The following antimicrobials commonly used for the treatment of C.difficile infections or applied previously in C.difficile epidemiological studies were tested: metronidazole, vancomycin, meropenem, ceftriaxone, ampicillin-sulbactam, clindamycin, erythromycin, moxifloxacin, tetracycline, doxycycline, tigecycline and linezolid.",True,"'Does the phrase ""Tetracycline treats Infection"" receive at least indirect support from the statement: ""The following antimicrobials commonly used for the treatment of C.difficile infections or applied previously in C.difficile epidemiological studies were tested: metronidazole, vancomycin, meropenem, ceftriaxone, ampicillin-sulbactam, clindamycin, erythromycin, moxifloxacin, tetracycline, doxycycline, tigecycline and linezolid.""?","Yes, the statement does provide indirect support for the phrase ""Tetracycline treats Infections."" The statement lists tetracycline as one of the antimicrobials tested in epidemiological studies related to C.difficile infections. This implies that tetracycline was considered as a potential treatment for these infections, suggesting its antimicrobial properties and thus its potential to treat infections. However, it is important to note that indirect support does not equate to definitive proof of efficacy in treating infections caused by C.difficile specifically. It would be necessary to review additional evidence regarding tetracycline's specific effectiveness against C.difficile infections for more direct support of that claim." +15910237,Tetracycline treats eye infectious disorder,1394,"In addition, resistance to azithromycin, erythromycin, tetracycline, and trimethoprim was greater than 10%, which may be relevant when selecting empiric treatments for ocular surface infections.",True,"'Does the phrase ""Tetracycline treats eye infectious disorder"" receive at least indirect support from the statement: ""In addition, resistance to azithromycin, erythromycin, tetracycline, and trimethoprim was greater than 10%, which may be relevant when selecting empiric treatments for ocular surface infections.""?","Yes, indirectly it does lend some support. The statement mentions that resistance to tetracycline among ocular surface infections is greater than 10%. This implies that tetracycline continues to have some efficacy against these infections despite the noted resistance, otherwise it wouldn't be relevant for empiric treatments. However, it doesn't explicitly state that tetracycline treats eye infectious disorders, but rather that it maintains some level of effectiveness despite increasing resistance. It is also important to note that the most effective treatment would depend on the specific type of infection and its susceptibility profile." +10596737,Tetracycline treats osteomyelitis,1395,[Clinical considerations on the topical use of a new hydrosoluble tetracycline derivative in chronic osteomyelitis].,True,"'Does the phrase ""Tetracycline treats osteomyelitis"" receive at least indirect support from the statement: ""[Clinical considerations on the topical use of a new hydrosoluble tetracycline derivative in chronic osteomyelitis].""?","Yes, the statement ""Tetracycline treats osteomyelitis"" can receive indirect support from the title ""[Clinical considerations on the topical use of a new hydrosoluble tetracycline derivative in chronic osteomyelitis]."" This is because tetracycline is mentioned in the context of osteomyelitis treatment, albeit in its derivative form and as topical use. However, it does not provide direct evidence of tetracycline treating osteomyelitis as it refers specifically to a derivative of tetracycline used topically in treating chronic osteomyelitis. - - However, it is important to note that while binding often leads to some form of interaction, it does not necessarily mean that there is a direct physical interaction in the sense that one molecule is mechanically intertwined with another. In this case, Ciprofloxacin is likely interfering with the function of DNA gyrase enzymes by binding near their active sites, thereby inhibiting their activity without physically attaching in a mechanically" -8212496,Ciprofloxacin physically interacts with DNA Gyrase,1327,Topoisomerase IV and DNA gyrase were purified from a ciprofloxacin-sensitive Streptococcus pneumoniae strain and from two clinical isolates of S. pneumoniae with high-level resistance to ciprofloxacin by means of a gene cloning method in Escherichia coli.,False,Is the triple 'Ciprofloxacin physically interacts with DNA Gyrase' supported by the sentence: 'Topoisomerase IV and DNA gyrase were purified from a ciprofloxacin-sensitive Streptococcus pneumoniae strain and from two clinical isolates of S. pneumoniae with high-level resistance to ciprofloxacin by means of a gene cloning method in Escherichia coli.'?,"No, the statement does not provide direct support for the phrase ""Ciprofloxacin physically interacts with DNA Gyrase."" While it does mention that Ciprofloxacin is an antibiotic that affects S. pneumoniae strains (sensitive and resistant) by interacting with topoisomerase IV and DNA gyrase (enzymes involved in DNA replication), it does not explicitly state that Ciprofloxacin physically interacts with DNA Gyrase in vivo or in vitro. + To further elaborate on tetracycline antibiotics like doxycycline, minocycline, and tigecycline, they have been used in treating osteomyelitis due to their ability to penetrate bone tissue effectively (Gentry et al., 2017). Nonetheless, for tetracycline itself, there is limited evidence specifically addressing its effectiveness in treating osteomyelitis compared to other tetracycline antibiotics (Bratzler et al., 2013)." +10513439,Tetracycline treats bacterial infectious disease,1396,Nystatin and tetracycline in the treatment of bacterial infections.,True,"'Does the phrase ""Tetracycline treats bacterial infectious disease"" receive at least indirect support from the statement: ""Nystatin and tetracycline in the treatment of bacterial infections.""?","Yes, the phrase ""Tetracycline treats bacterial infectious disease"" does receive indirect support from the statement: ""Nystatin and tetracycline in the treatment of bacterial infections."" - However, indirect support might be inferred from established knowledge about Ciprofloxacin as a fluoroquinolone antibiotic that inhibits bacterial DNA gyrase (topoisomerase II) by stabilizing the covalent DNA-enzyme complex (cleavable complex), leading to double-strand DNA breaks and bacterial cell death [1]. + The reason for my affirmative answer lies in the fact that tetracycline is explicitly mentioned alongside nystatin in the context of treating bacterial infections. Given that nystatin is an antifungal medication not used for treating bacterial infections, its inclusion in the statement appears incidental; thus, tetracycline remains the primary antibacterial agent in question. - + Tetracycline is an antibiotic commonly used for treating various bacterial infections due to its ability to inhibit protein synthesis in bacteria by binding to their 30S ribosomal subunit (Chopra & Roberts, 2001). Therefore, ample evidence supports tetracycline as an effective antibacterial agent for treating infectious diseases caused by susceptible bacteria (Luna & Luna, 2019). - In summary, while there is no direct evidence in the statement provided for Ciprofloxacin physically interacting with DNA Gyrase, such an interaction is consistent with existing knowledge about Ciproflo" -7781719,Ciprofloxacin affects DNA Gyrase,1328,"The concentrations of ciprofloxacin, sparfloxacin, levofloxacin, or ofloxacin required to inhibit wild-type topoisomerase IV were 8 to 16 times lower than those required to inhibit wild-type DNA gyrase.",True,"Is the triple 'Ciprofloxacin affects DNA Gyrase' supported by the sentence: 'The concentrations of ciprofloxacin, sparfloxacin, levofloxacin, or ofloxacin required to inhibit wild-type topoisomerase IV were 8 to 16 times lower than those required to inhibit wild-type DNA gyrase.'?","Yes, the statement does provide indirect support for the phrase ""Ciprofloxacin affects DNA Gyrase"". The statement implies that ciprofloxacin has an effect on topoisomerase IV, which is a type of enzyme that controls DNA supercoiling - a process closely related to DNA gyrase. DNA gyrase is another type of topoisomerase that introduces negative supercoils into DNA during replication and transcription. Both topoisomerase IV and DNA gyrase belong to the family of enzymes called topoisomerases that control and alter the topological states of DNA during various cellular processes. + It is important to note that while tetracycline has demonstrated efficacy against bacterial infections in" +10332719,Tetracycline treats periodontitis,1397,Meta-analysis of local tetracycline in treating chronic periodontitis.,True,"'Does the phrase ""Tetracycline treats periodontitis"" receive at least indirect support from the statement: ""Meta-analysis of local tetracycline in treating chronic periodontitis.""?","Yes, the phrase ""Tetracycline treats periodontitis"" does receive indirect support from the statement ""Meta-analysis of local tetracycline in treating chronic periodontitis."" A meta-analysis is a systematic review of multiple studies that uses statistical methods to combine their results. It provides a higher level of evidence than individual studies because it increases statistical power and reduces type I (false positive) and type II (false negative) errors. - The fact that ciprofloxacin inhibits wild-type topoisomerase IV at lower concentrations than those required for DNA gyrase inhibition suggests that ciprofloxacin has some level of interaction with DNA gyrase as well. This is because both enzymes share structural similarities and functional mechanisms despite their differences in substrate specificity and cellular roles. Therefore, it is plausible that ciprofloxacin affects DNA gyrase either directly by binding to" -18400322,Ciprofloxacin affects DNA Gyrase,1329,Plasmid-encoded protein QnrB1 protects DNA gyrase from ciprofloxacin inhibition.,True,Is the triple 'Ciprofloxacin affects DNA Gyrase' supported by the sentence: 'Plasmid-encoded protein QnrB1 protects DNA gyrase from ciprofloxacin inhibition.'?,"Yes, the statement does provide indirect support for the phrase ""Ciprofloxacin affects DNA Gyrase."" The provided information indicates that plasmid-encoded protein QnrB1 protects DNA gyrase from ciprofloxacin inhibition. This implies that ciprofloxacin typically inhibits DNA gyrase, as there would be no need for protection if it did not have that effect. Therefore, it suggests that ciprofloxacin does indeed affect DNA gyrase. + In this case, the meta-analysis specifically focuses on local tetracycline use in treating chronic periodontitis. The fact that such a study was conducted suggests that there is enough existing literature supporting the potential positive effects of tetracycline on periodontitis for researchers to deem it worthwhile to perform such an analysis. Therefore, while not definitive proof, it does lend indirect support to the claim that tetracycline can be used to treat periodontitis. - However, it is important to note that while this statement provides indirect evidence for ciprofloxacin affecting DNA gyrase, it does not necessarily prove causation nor does it provide direct evidence for the mechanism by which ciprofloxacin impacts DNA gyrase. Further investigation would be required to confirm these details." -24010235,Ciprofloxacin treats chronic bronchitis,1330,"Thirty four patients with acute purulent exacerbations of chronic bronchitis were treated with 500 mg ciprofloxacin twice daily, orally, for ten days.",True,"Is the triple 'Ciprofloxacin treats chronic bronchitis' supported by the sentence: 'Thirty four patients with acute purulent exacerbations of chronic bronchitis were treated with 500 mg ciprofloxacin twice daily, orally, for ten days.'?","Yes, indirectly it does lend some support to the statement ""Ciprofloxacin treats chronic bronchitis"". The provided evidence states that 34 patients with acute purulent exacerbations of chronic bronchitis were treated with Ciprofloxacin for ten days. This implies that Ciprofloxacin was used as a treatment for these patients suffering from chronic bronchitis exacerbations, which can be considered supportive evidence that Ciprofloxacin is used in treating chronic bronchitis in some capacity. However, it is essential to note that this is indirect evidence; it does not explicitly demonstrate that Ciprofloxacin can cure chronic bronchitis but rather that it might be an option for treating its complications (acute purulent exacerbations). Additionally, it would be important to consider other factors such as potential side effects, efficacy compared to other treatment options, and whether long-term use is recommended before making definitive conclusions about Ciprofloxacin as a treatment for chronic bronchitis." -22484062,Ciprofloxacin treats amyotrophic lateral sclerosis,1331,"OBJECTIVE: To evaluate the efficacy of a fixed-dose combination of two approved drugs, Ciprofloxacin and Celecoxib, as a potential therapeutic treatment for amyotrophic lateral sclerosis (ALS).",False,"Is the triple 'Ciprofloxacin treats amyotrophic lateral sclerosis' supported by the sentence: 'OBJECTIVE: To evaluate the efficacy of a fixed-dose combination of two approved drugs, Ciprofloxacin and Celecoxib, as a potential therapeutic treatment for amyotrophic lateral sclerosis (ALS).'?","No, the statement does not provide any direct support for the claim that ""Ciprofloxacin treats amyotrophic lateral sclerosis."" The objective in question is investigating the efficacy of a combination therapy that includes Ciprofloxacin for treating ALS, not Ciprofloxacin in isolation. This suggests that the researchers might believe that Ciprofloxacin could have some therapeutic potential in treating ALS as part of a combination treatment but does not confirm its efficacy as a standalone treatment for ALS. The statement also does not provide any indirect evidence for Ciprofloxacin's efficacy in treating ALS since it only mentions an ongoing evaluation without presenting any results or outcomes from studies on Ciprofloxacin as an ALS treatment." -21488232,Ciprofloxacin treats Infection,1332,Noncytotoxic Pyrrolobenzodiazepine-Ciprofloxacin Conjugate with Activity against Mycobacterium tuberculosis .The development of new antitubercular agents for the treatment of infections caused by multidrug-resistant (MDR) Mycobacterium tuberculosis is an urgent priority.,False,Is the triple 'Ciprofloxacin treats Infection' supported by the sentence: 'Noncytotoxic Pyrrolobenzodiazepine-Ciprofloxacin Conjugate with Activity against Mycobacterium tuberculosis .The development of new antitubercular agents for the treatment of infections caused by multidrug-resistant (MDR) Mycobacterium tuberculosis is an urgent priority.'?,"No, the phrase ""Ciprofloxacin treats Infection"" does not receive direct support from the statement provided. The statement discusses the development of a new antitubercular agent, specifically a noncytotoxic Pyrrolobenzodiazepine-Ciprofloxacin Conjugate, for treating infections caused by multidrug-resistant Mycobacterium tuberculosis. However, it does not confirm that Ciprofloxacin alone treats infections. Indirectly, it suggests that Ciprofloxacin may be useful in conjunction with other agents for treating certain types of infections, but it does not provide direct evidence that Ciprofloxacin is an effective standalone treatment for any infection." -20040173,Ciprofloxacin treats lymphoma,1333,Antibacterial prophylaxis with ciprofloxacin for patients with multiple myeloma and lymphoma undergoing autologous haematopoietic cell transplantation: a quasi-experimental single-centre before-after study.,False,Is the triple 'Ciprofloxacin treats lymphoma' supported by the sentence: 'Antibacterial prophylaxis with ciprofloxacin for patients with multiple myeloma and lymphoma undergoing autologous haematopoietic cell transplantation: a quasi-experimental single-centre before-after study.'?,"No, the phrase ""Ciprofloxacin treats lymphoma"" does not receive indirect support from the statement: ""Antibacterial prophylaxis with ciprofloxacin for patients with multiple myeloma and lymphoma undergoing autologous haematopoietic cell transplantation: a quasi-experimental single-centre before-after study."" + However, it is important to note that even meta-analyses have limitations. For instance, they rely on the quality of the original studies included, which may vary in their design, execution, reporting, and other factors that could influence their results. Moreover, meta-analys" +7227539,Tetracycline treats Helicobacter pylori infectious disease,1398,"Ranitidine bismuth citrate, tetracycline, clarithromycin twice-a-day triple therapy for clarithromycin susceptible Helicobacter pylori infection.",True,"'Does the phrase ""Tetracycline treats Helicobacter pylori infectious disease"" receive at least indirect support from the statement: ""Ranitidine bismuth citrate, tetracycline, clarithromycin twice-a-day triple therapy for clarithromycin susceptible Helicobacter pylori infection.""?","Yes, indirect support can be inferred from the statement provided. The given statement refers to a triple therapy regimen for treating Helicobacter pylori infection that includes tetracycline as one of its components. This suggests that tetracycline is an effective antibiotic against Helicobacter pylori infection when used in combination therapy, thus lending indirect support to the claim that tetracycline treats Helicobacter pylori infectious disease. However, it is important to note that antibiotics like tetracycline typically require combination therapy due to bacterial resistance; therefore, monotherapy might not be as effective in treating Helicobacter pylori infection as combination therapy like the one mentioned in the statement provided." +22788639,(Alginate)n treats Pain,1399,"With these results, we propose alginate-based nanoemulsions as a potential treatment for migraine pain.",True,"'Does the phrase ""(Alginate)n treats Pain"" receive at least indirect support from the statement: ""With these results, we propose alginate-based nanoemulsions as a potential treatment for migraine pain.""?","Yes, the phrase ""(Alginate)n treats Pain"" does receive indirect support from the statement: ""With these results, we propose alginate-based nanoemulsions as a potential treatment for migraine pain."" - The study mentioned is investigating the effectiveness of administering ciprofloxacin as an antibacterial prophylaxis for patients undergoing autologous haematopoietic cell transplantation who have multiple myeloma or lymphoma. The purpose is to prevent bacterial infections during the transplantation process rather than treating lymphoma itself. + The indirect support arises from the fact that the statement proposes alginate-based nanoemulsions as a potential treatment for migraine pain, which implies that alginate has some therapeutic effect on pain, specifically migraine pain in this case. The term ""(Alginate)n"" in the phrase can be interpreted as referring to alginate in any form, including nanoemulsions. Therefore, there is an implication that alginate can treat pain, although it is important to note that this is an indirect inference based on the provided statement. - The misconception may arise from conflating treating bacterial infections (for which ciprofloxacin is effective) that lymphoma patients might experience during transplantation with treating lymphoma itself. Ciprofloxacin is an antibiotic that is not indicated for treating lymphoma; instead, chemotherapy regimens along" -19067853,Ciprofloxacin treats B-cell chronic lymphocytic leukemia,1334,A case of septic arthritis caused by a Mycoplasma salivarium strain resistant towards Ciprofloxacin and Clarithromycin in a patient with chronic lymphatic leukemia.,False,Is the triple 'Ciprofloxacin treats B-cell chronic lymphocytic leukemia' supported by the sentence: 'A case of septic arthritis caused by a Mycoplasma salivarium strain resistant towards Ciprofloxacin and Clarithromycin in a patient with chronic lymphatic leukemia.'?,"No, the statement does not provide indirect support for the claim that Ciprofloxacin treats B-cell chronic lymphocytic leukemia (B-CLL). The statement describes a case where a patient with B-CLL developed septic arthritis caused by a Ciprofloxacin-resistant strain of Mycoplasma salivarium. The fact that Ciprofloxacin was ineffective against this specific bacterial infection in an individual with B-CLL does not imply that Ciprofloxacin has therapeutic effects on B-CLL itself. + However, it is crucial to emphasize that this is an extrapolation of the original statement, which specifically mentions migraine pain. The efficacy of alginate in treating other types of pain has not been addressed in the statement. Therefore, any generalization beyond migraine pain should be made with caution and should ideally be supported by further evidence." +11016107,(Alginate)n treats gastroesophageal reflux disease,1400,An open multicenter study was performed to assess the efficacy and safety of alginic acid in two different dosages in 76 pediatric patients with gastroesophageal reflux confirmed by pH monitoring.,True,"'Does the phrase ""(Alginate)n treats gastroesophageal reflux disease"" receive at least indirect support from the statement: ""An open multicenter study was performed to assess the efficacy and safety of alginic acid in two different dosages in 76 pediatric patients with gastroesophageal reflux confirmed by pH monitoring.""?","Yes, indirect support can be inferred from the statement provided. The study in question investigates the efficacy and safety of alginic acid in treating gastroesophageal reflux in pediatric patients. Alginic acid is one of the main components of alginate, which is often used in over-the-counter medications for gastroesophageal reflux disease (GERD). - B-CLL is a type of cancer affecting white blood cells (B-lymphocytes), while Ciprofloxacin is an antibiotic used primarily for treating bacterial infections by inhibiting DNA gyrase, thereby interfering with bacterial DNA replication. Antibiotics like Ciprofloxacin have no direct therapeutic effect on cancer cells; thus, there is no reason to infer that Ciprofloxacin would be useful in treating B-CLL based on" -14572951,Ciprofloxacin treats hearing loss disorder,1335,Treatment with ciprofloxacin and ceftazidime improved the hearing loss significantly.,False,Is the triple 'Ciprofloxacin treats hearing loss disorder' supported by the sentence: 'Treatment with ciprofloxacin and ceftazidime improved the hearing loss significantly.'?,"No, the phrase ""Ciprofloxacin treats hearing loss disorder"" does not receive direct support from the statement: ""Treatment with ciprofloxacin and ceftazidime improved the hearing loss significantly."" + However, it is essential to emphasize that the statement does not explicitly support ""(Alginate)n treats gastroesophageal reflux disease."" The study investigates alginic acid in two different dosages rather than (Alginate)n specifically. Moreover, it is crucial to wait for the actual results of the study before making any definitive conclusions about its implications for GERD treatment using alginate-based formulations. - - The statement only indicates that there was an improvement in hearing loss when both ciprofloxacin and ceftazidime were used together. It does not specify whether ciprofloxacin alone was responsible for the improvement in hearing loss or if ceftazidime played a role as well. Therefore, it is inappropriate to make a definitive claim about ciprofloxacin treating hearing loss disorder based solely on this evidence. Further investigation would be required to determine the specific effects of ciprofloxacin on hearing loss disorder." -14398199,Ciprofloxacin treats sinusitis,1336,"CASE SUMMARY: A 24-year-old woman was admitted to the hospital because of convulsions, severe myopathy, and acute renal failure after taking ciprofloxacin for sinusitis, and urinary tract infections.",False,"Is the triple 'Ciprofloxacin treats sinusitis' supported by the sentence: 'CASE SUMMARY: A 24-year-old woman was admitted to the hospital because of convulsions, severe myopathy, and acute renal failure after taking ciprofloxacin for sinusitis, and urinary tract infections.'?","No, the statement does not provide indirect support for the claim that ""Ciprofloxacin treats sinusitis."" In fact, it suggests quite the opposite: that ciprofloxacin may have severe side effects in some patients when used to treat sinusitis. This is an important distinction because while ciprofloxacin can be used to treat certain types of bacterial infections (including some cases of sinusitis), it does not necessarily follow that taking ciprofloxacin for sinusitis will always be safe or effective for every patient. + Nonetheless, since alginic acid is an essential component of alginate-based medications used in treating GERD symptoms, it is reasonable to infer indirect support for the potential benefits of alginate in treating GERD based on such studies. This is especially true if the study results demonstrate significant improvements in treating gastroesophageal refl" +22283339,Chlorhexidine treats Peri-Implantitis,1401,There is a need for more homogenous RCTs with large sample size to define the role of CHX in non-surgical management of peri-implant mucositis and peri-implantitis.,False,"'Does the phrase ""Chlorhexidine treats Peri-Implantitis"" receive at least indirect support from the statement: ""There is a need for more homogenous RCTs with large sample size to define the role of CHX in non-surgical management of peri-implant mucositis and peri-implantitis.""?","No, the phrase ""Chlorhexidine treats Peri-Implantitis"" does not receive at least indirect support from the statement provided. The statement suggests that there is a need for more homogenous randomized controlled trials (RCTs) with larger sample sizes to define the role of chlorhexidine (CHX) in non-surgical management of peri-implant mucositis and peri-implantitis. This implies that while there may be some evidence supporting the use of CHX in managing these conditions, it is not yet definitive due to the lack of high-quality evidence from large-scale RCTs. Therefore, one cannot infer that CHX treats peri-implantitis based on this statement alone." +14556561,Chlorhexidine treats pneumonia,1402,"Among patients without pneumonia at baseline, pneumonia developed in 24% (CPIS >or=6) by day 3 in those treated with chlorhexidine.",False,"'Does the phrase ""Chlorhexidine treats pneumonia"" receive at least indirect support from the statement: ""Among patients without pneumonia at baseline, pneumonia developed in 24% (CPIS >or=6) by day 3 in those treated with chlorhexidine.""?","No, the statement does not provide indirect support for the phrase ""Chlorhexidine treats pneumonia."" The statement indicates that among patients who did not have pneumonia at baseline, 24% of those treated with chlorhexidine developed pneumonia by day 3 (given that their Clinical Pulmonary Infection Score (CPIS) was greater than or equal to 6). This suggests a potential association between chlorhexidine treatment and an increased risk of developing pneumonia in patients who did not have it at baseline. However, it does not support the idea that chlorhexidine is an effective treatment for pneumonia because it does not demonstrate any reduction in pneumonia symptoms or prevention of pneumonia in patients who were already diagnosed with it." +14034776,Chlorhexidine treats dental caries,1403,"Sodium fluoride and chlorhexidine effect in the inhibition of mutans streptococci in children with dental caries: a randomized, double-blind clinical trial.",True,"'Does the phrase ""Chlorhexidine treats dental caries"" receive at least indirect support from the statement: ""Sodium fluoride and chlorhexidine effect in the inhibition of mutans streptococci in children with dental caries: a randomized, double-blind clinical trial.""?","Yes, there is indirect support for the phrase ""Chlorhexidine treats dental caries"" from the statement provided. The study examines the effects of both sodium fluoride and chlorhexidine on inhibiting mutans streptococci in children with dental caries, which suggests that chlorhexidine has some impact on treating dental caries given that mutans streptococci is a primary causative agent of dental caries. However, it is important to note that the statement does not explicitly claim that chlorhexidine treats dental caries; rather it suggests an inhibitory effect on mutans streptococci in children who already have dental caries." +13966318,Chlorhexidine treats bacterial infectious disease with sepsis,1404,"All patients with B. stabilis bacteraemia had indwelling intravenous catheters, which were treated with chlorhexidine to disinfect the catheters.",False,"'Does the phrase ""Chlorhexidine treats bacterial infectious disease with sepsis"" receive at least indirect support from the statement: ""All patients with B. stabilis bacteraemia had indwelling intravenous catheters, which were treated with chlorhexidine to disinfect the catheters.""?","No, the statement does not provide direct or indirect support for the phrase ""Chlorhexidine treats bacterial infectious disease with sepsis."" The statement indicates that chlorhexidine was used to disinfect indwelling intravenous catheters in patients with B. stabilis bacteraemia, but it does not suggest that chlorhexidine was used as a treatment for bacterial infectious disease or sepsis itself. Chlorhexidine is an antiseptic commonly used for skin disinfection and catheter care due to its broad-spectrum antimicrobial activity; however, its use in treating systemic bacterial infections is not established. Therefore, while chlorhexidine may help prevent bacterial infections related to catheter use, it does not necessarily imply that it can treat bacterial infectious diseases associated with sepsis." +13955725,Chlorhexidine treats bacterial infectious disease,1405,Chlorhexidine (CHX) is effective in treating oral bacterial infections.,True,"'Does the phrase ""Chlorhexidine treats bacterial infectious disease"" receive at least indirect support from the statement: ""Chlorhexidine (CHX) is effective in treating oral bacterial infections.""?","Yes, the statement ""Chlorhexidine (CHX) is effective in treating oral bacterial infections"" does provide indirect support for the phrase ""Chlorhexidine treats bacterial infectious disease."" This is because oral infections are indeed a type of bacterial infectious disease. However, it is important to note that this support is indirect because it pertains specifically to oral infections rather than bacterial infectious diseases in general. Therefore, while the evidence does suggest that chlorhexidine has antibacterial properties that can be beneficial in treating certain types of bacterial infections (such as those occurring in the oral cavity), it may not necessarily be effective in treating all bacterial infectious diseases in all body sites." +13614413,Chlorhexidine treats stomatitis,1406,CONCLUSIONS: The frequency and duration of OM are significantly improved by prophylactic chlorhexidine and by cryotherapy.,True,"'Does the phrase ""Chlorhexidine treats stomatitis"" receive at least indirect support from the statement: ""CONCLUSIONS: The frequency and duration of OM are significantly improved by prophylactic chlorhexidine and by cryotherapy.""?","Yes, indirect support can be inferred from the statement provided. - The case summary describes adverse reactions experienced by a patient who took ciprofloxacin for both sinusitis and urinary tract infections. While ciprofloxacin might have been appropriate for treating her urinary tract infection (assuming she had a bacterial infection sensitive to ciprofloxacin), its use in treating her sinusitis appears to have resulted in severe side effects. Therefore, one could argue that ciprofloxacin is not an ideal treatment for sinusitis in this particular case. + The conclusion statement is from a study investigating the effects of prophylactic chlorhexidine and cryotherapy on oral mucositis (OM) in patients undergoing chemoradiation for head-and-neck cancer. The study found that both prophylactic chlorhexidine and cryotherapy significantly improved the frequency and duration of OM. - It is essential for healthcare providers" -14311974,Ciprofloxacin treats liver abscess (disease),1337,Chromobacterium violaceum endocarditis and hepatic abscesses treated successfully with meropenem and ciprofloxacin.,True,Is the triple 'Ciprofloxacin treats liver abscess (disease)' supported by the sentence: 'Chromobacterium violaceum endocarditis and hepatic abscesses treated successfully with meropenem and ciprofloxacin.'?,"Yes, indirect support can be inferred from the statement ""Chromobacterium violaceum endocarditis and hepatic abscesses treated successfully with meropenem and ciprofloxacin."" + Stomatitis is a type of oral mucositis characterized by inflammation of the oral mucous membrane. Therefore, if chlorhexidine can improve the frequency and duration of oral mucositis, it can be inferred that it could potentially have a positive impact on stomatitis as well, given that stomatitis is a form of oral mucositis. However, it is important to note that this is an indirect inference based on the provided statement, and direct evidence specifically linking chlorhexidine to stomatitis treatment would strengthen this conclusion." +12567084,Chlorhexidine treats infectious disease,1407,"We developed an efficacious and non-irritant mouthwash that is alcohol-free and that has a low concentration of chlorhexidine, in order to be used for preventing oral cavity infections in immunocompromised and cancer patients.",True,"'Does the phrase ""Chlorhexidine treats infectious disease"" receive at least indirect support from the statement: ""We developed an efficacious and non-irritant mouthwash that is alcohol-free and that has a low concentration of chlorhexidine, in order to be used for preventing oral cavity infections in immunocompromised and cancer patients.""?","Yes, the statement does provide indirect support for the phrase ""Chlorhexidine treats infectious disease"". The development of an efficacious mouthwash containing chlorhexidine implies that chlorhexidine has antimicrobial properties, which can be useful in treating infectious diseases. However, it is important to note that while chlorhexidine can help prevent infections in specific contexts (such as preventing oral cavity infections in immunocompromised and cancer patients), it does not necessarily mean that chlorhexidine can treat all types of infectious diseases. The effectiveness of chlorhexidine would depend on the specific pathogen and the site of infection." +12447822,Chlorhexidine treats Neonatal sepsis,1408,"However, 2 large but not randomized studies, one in Malawi and the other in Egypt, suggest that important reductions in maternal and neonatal sepsis and neonatal mortality may be achievable with vaginal or neonatal chlorhexidine treatment.",True,"'Does the phrase ""Chlorhexidine treats Neonatal sepsis"" receive at least indirect support from the statement: ""However, 2 large but not randomized studies, one in Malawi and the other in Egypt, suggest that important reductions in maternal and neonatal sepsis and neonatal mortality may be achievable with vaginal or neonatal chlorhexidine treatment.""?","Yes, while the statement does not explicitly say that chlorhexidine treats neonatal sepsis, it does provide indirect support for this claim. The statement mentions two large studies conducted in Malawi and Egypt which suggest that significant reductions in maternal and neonatal sepsis as well as neonatal mortality may be achievable through vaginal or neonatal chlorhexidine treatment. Neonatal sepsis is a type of infection that newborn babies can get, so it stands to reason that reducing neonatal sepsis would also reduce instances of neonatal sepsis being treated. However, it is important to note that correlation does not imply causation; further investigation would be needed to definitively establish that chlorhexidine treatment causes a reduction in neonatal sepsis instances." +11792004,Chlorhexidine treats periodontal disorder,1409,BACKGROUND: Tooth staining is a common feature of chlorhexidine treatment for periodontal disease and there is a large variation between patients as to the degree of their tooth staining.,False,"'Does the phrase ""Chlorhexidine treats periodontal disorder"" receive at least indirect support from the statement: ""BACKGROUND: Tooth staining is a common feature of chlorhexidine treatment for periodontal disease and there is a large variation between patients as to the degree of their tooth staining.""?","No, the statement does not provide direct or indirect support for the phrase ""Chlorhexidine treats periodontal disorder."" The provided background information discusses tooth staining as a side effect of chlorhexidine treatment for periodontal disease rather than its therapeutic effect on the disorder itself. Therefore, it does not offer evidence that chlorhexidine is an effective treatment for periodontal disease." +10593306,Chlorhexidine treats eye infectious disorder,1410,Clinical trial of chlorhexidine and diaminodiphenylsulphone in superficial ocular infections.,True,"'Does the phrase ""Chlorhexidine treats eye infectious disorder"" receive at least indirect support from the statement: ""Clinical trial of chlorhexidine and diaminodiphenylsulphone in superficial ocular infections.""?","Yes, the statement ""Clinical trial of chlorhexidine and diaminodiphenylsulphone in superficial ocular infections"" does provide indirect support for the claim that ""Chlorhexidine treats eye infectious disorder"". The reason is that conducting a clinical trial implies that chlorhexidine was being tested for its potential therapeutic effect on superficial ocular infections. However, it is important to note that indirect support does not equate to definitive proof of efficacy. The results of the clinical trial would need to be examined in order to determine whether chlorhexidine was found to be effective in treating eye infections. Additionally, it should be noted that chlorhexidine may not be the sole active ingredient in the treatment of eye infections as it was tested in combination with diaminodiphenylsulphone in the clinical trial mentioned." +7869752,Chlorhexidine treats gingivitis,1411,"The abrasiveness of the chew, rather than the antibacterial activity of chlorhexidine, is likely to have contributed the most to the maintenance of oral health in dogs with mild gingivitis.",False,"'Does the phrase ""Chlorhexidine treats gingivitis"" receive at least indirect support from the statement: ""The abrasiveness of the chew, rather than the antibacterial activity of chlorhexidine, is likely to have contributed the most to the maintenance of oral health in dogs with mild gingivitis.""?","No, the statement does not provide indirect support for the phrase ""Chlorhexidine treats gingivitis."" The statement suggests that an abrasive property of a chew is primarily responsible for maintaining oral health in dogs with mild gingivitis, rather than chlorhexidine's antibacterial activity. This implies that chlorhexidine may not be the main factor in treating gingivitis in this context. However, it does not necessarily mean that chlorhexidine has no effect on gingivitis; it only indicates that its antibacterial activity might not be as significant as its abrasive counterpart in the specific scenario presented in the statement." +7287519,Chlorhexidine treats periodontitis,1412,Assessing the effectiveness of locally delivered chlorhexidine in the treatment of periodontitis.,True,"'Does the phrase ""Chlorhexidine treats periodontitis"" receive at least indirect support from the statement: ""Assessing the effectiveness of locally delivered chlorhexidine in the treatment of periodontitis.""?","Yes, the phrase ""Chlorhexidine treats periodontitis"" does receive indirect support from the statement ""Assessing the effectiveness of locally delivered chlorhexidine in the treatment of periodontitis."" This is because the assessment of effectiveness implies that there is a potential for treatment, which suggests that chlorhexidine has some capacity to treat periodontitis. However, it is important to note that this statement only provides indirect support; direct evidence would require clinical trial results demonstrating significant improvements in periodontitis symptoms after chlorhexidine treatment compared to placebo or other treatments." +7281939,Chlorhexidine treats Acanthamoeba keratitis,1413,Treatment of acanthamoeba keratitis with chlorhexidine.,True,"'Does the phrase ""Chlorhexidine treats Acanthamoeba keratitis"" receive at least indirect support from the statement: ""Treatment of acanthamoeba keratitis with chlorhexidine.""?","Yes, indirect support can be inferred from the statement ""Treatment of acanthamoeba keratitis with chlorhexidine."" The phrase ""treatment of"" implies that there is evidence suggesting chlorhexidine can have an impact on Acanthamoeba keratitis, thus providing indirect support for the claim that chlorhexidine treats Acanthamoeba keratitis. However, it is important to note that ""treatment"" does not necessarily mean ""cure,"" so further investigation would be needed to determine the exact nature of chlorhexidine's effect on Acanthamoeba keratitis." +22179313,Nicergoline treats depressive disorder,1414,"The Efficacy of Sertraline, Escitalopram, and Nicergoline in the Treatment of Depression and Apathy in Alzheimer's Disease: The Okayama Depression and Apathy Project (ODAP).BACKGROUND: Neuropsychiatric symptoms of dementia such as depression and apathy in patients with Alzheimer's disease (AD) are associated with a lower quality of life.",True,"'Does the phrase ""Nicergoline treats depressive disorder"" receive at least indirect support from the statement: ""The Efficacy of Sertraline, Escitalopram, and Nicergoline in the Treatment of Depression and Apathy in Alzheimer's Disease: The Okayama Depression and Apathy Project (ODAP).BACKGROUND: Neuropsychiatric symptoms of dementia such as depression and apathy in patients with Alzheimer's disease (AD) are associated with a lower quality of life.""?","Yes, indirect support can be inferred from the statement provided. The Okayama Depression and Apathy Project (ODAP) study examines the efficacy of Sertraline, Escitalopram, and Nicergoline in treating depression and apathy in Alzheimer's Disease (AD). The mention of Nicergoline in this context suggests that it is being investigated as a potential treatment for depressive symptoms associated with AD. However, it is crucial to note that this does not constitute definitive proof of Nicergoline's efficacy in treating depressive disorder; it only indicates that it is being studied for that purpose. Additionally, the study focuses on AD patients, so any potential benefits for individuals without AD remain unknown." +9203015,Nicergoline treats dementia,1415,"OBJECTIVES: To determine whether there is evidence of efficacy of nicergoline in the treatment of dementia and other age-associated forms of cognitive decline,and to assess the safety and tolerability of the drug.",True,"'Does the phrase ""Nicergoline treats dementia"" receive at least indirect support from the statement: ""OBJECTIVES: To determine whether there is evidence of efficacy of nicergoline in the treatment of dementia and other age-associated forms of cognitive decline,and to assess the safety and tolerability of the drug.""?","Yes, the statement does provide indirect support for the claim that ""Nicergoline treats dementia."" The objectives outlined in the statement include determining whether there is evidence of efficacy of nicergoline in the treatment of dementia, which implies that there is at least some expectation or prior evidence suggesting that nicergoline may have potential benefits in treating dementia. However, it is important to note that these objectives do not necessarily confirm that nicergoline treats dementia, as further investigation and evidence would be required to make such a definitive claim. Additionally, assessing safety and tolerability of the drug is not direct evidence of its efficacy in treating dementia but rather an essential aspect of drug evaluation before it can be considered for therapeutic use in patients." +22026892,RAMUCIRUMAB treats adenocarcinoma,1416,"Methods: In this retrospective two-center study, 56 patients with metastatic gastric cancer (47%) or adenocarcinoma of the GEJ (53%) were treated with paclitaxel and ramucirumab (n=38) as second-line (75%) or beyond second-line (25%) therapy.",True,"'Does the phrase ""RAMUCIRUMAB treats adenocarcinoma"" receive at least indirect support from the statement: ""Methods: In this retrospective two-center study, 56 patients with metastatic gastric cancer (47%) or adenocarcinoma of the GEJ (53%) were treated with paclitaxel and ramucirumab (n=38) as second-line (75%) or beyond second-line (25%) therapy.""?","Yes, indirect support can be inferred from the statement provided. The study involves patients diagnosed with either metastatic gastric cancer (47%) or adenocarcinoma of the gastroesophageal junction (GEJ) (53%). These patients were treated using ramucirumab in combination with paclitaxel as second-line therapy (75%) or beyond second-line therapy (25%). Adenocarcinoma is a subtype of gastric cancer; therefore, it is reasonable to infer that ramucirumab was used as part of the treatment for patients diagnosed with adenocarcinoma of the GEJ in particular. - + However, it is crucial to emphasize that while ramucirumab may be used as part of treatment regimens for adenocarcinoma, it does not necessarily mean that ramucirumab ""treats"" adenocarcinoma in isolation. The effectiveness of ramucirumab in treating adenocarcinoma would need further investigation beyond the scope of the information provided in the statement. This could include analyzing patient outcomes such as progression-free survival (P" +21622108,RAMUCIRUMAB treats non-small cell lung carcinoma,1417,This study aimed to validate the primary prophylactic use of pegfilgrastim with docetaxel and ramucirumab treatment in Japanese patients with NSCLC.,True,"'Does the phrase ""RAMUCIRUMAB treats non-small cell lung carcinoma"" receive at least indirect support from the statement: ""This study aimed to validate the primary prophylactic use of pegfilgrastim with docetaxel and ramucirumab treatment in Japanese patients with NSCLC.""?","Yes, indirect support can be inferred from the statement provided. The study aimed to validate the use of ramucirumab in combination with docetaxel for treating non-small cell lung carcinoma (NSCLC) in Japanese patients. This implies that ramucirumab is being considered as part of a treatment regimen for NSCLC. However, it does not explicitly state that ramucirumab treats NSCLC on its own; therefore, the support is indirect. - The statement implies that ciprofloxacin was part of a successful treatment regimen for hepatic abscesses caused by Chromobacterium violaceum. However, it does not explicitly state that ciprofloxacin alone treats liver abscesses (disease). The treatment success may be attributed to the combination of meropenem and ciprofloxacin, or other factors such as surgical interventions that were not specified in the statement. Therefore, while there is some level of indirect support for the claim, it is not definitive proof that ciprofloxacin is an effective sole treatment for liver abscesses caused by any organism." -14284683,Ciprofloxacin treats gastroenteritis,1338,"A patient is reported who had previously maintained a stable prothrombin time on Coumadin for 5 years, and who exhibited a marked prolongation of prothrombin time when placed on ciprofloxacin for gastroenteritis.",False,"Is the triple 'Ciprofloxacin treats gastroenteritis' supported by the sentence: 'A patient is reported who had previously maintained a stable prothrombin time on Coumadin for 5 years, and who exhibited a marked prolongation of prothrombin time when placed on ciprofloxacin for gastroenteritis.'?","No, the statement does not provide indirect support for the claim that ""Ciprofloxacin treats gastroenteritis."" The statement describes an incident where a patient on Coumadin developed a prolonged prothrombin time after being administered Ciprofloxacin for gastroenteritis. However, it does not suggest any therapeutic benefit of Ciprofloxacin for treating gastroenteritis. In fact, it implies that Ciprofloxacin may interact negatively with other medications like Coumadin." -14141218,Ciprofloxacin treats castration-resistant prostate carcinoma,1339,"Doxorubicin and docetaxel, two standard antineoplastic agents in hormone-refractory prostate cancer (HRPC) therapy and ciprofloxacin were evaluated singly and in several simultaneous and sequential drug combination schemes, against PC-3 and LNCaP cell lines.",False,"Is the triple 'Ciprofloxacin treats castration-resistant prostate carcinoma' supported by the sentence: 'Doxorubicin and docetaxel, two standard antineoplastic agents in hormone-refractory prostate cancer (HRPC) therapy and ciprofloxacin were evaluated singly and in several simultaneous and sequential drug combination schemes, against PC-3 and LNCaP cell lines.'?","No, the statement does not provide direct support for the claim that ""Ciprofloxacin treats castration-resistant prostate carcinoma"". The study mentioned in the statement is investigating the effects of ciprofloxacin in combination with other agents (doxorubicin and docetaxel) on PC-3 and LNCaP cell lines. However, it does not explicitly state that ciprofloxacin alone is effective in treating castration-resistant prostate carcinoma. Further investigation would be required to establish such a claim." -14005051,Ciprofloxacin treats acute myeloid leukemia,1340,"Results of combination therapy with amifostine, pentoxifylline, ciprofloxacin and dexamethasone in patients with myelodysplastic syndrome and acute myeloid leukemia.",False,"Is the triple 'Ciprofloxacin treats acute myeloid leukemia' supported by the sentence: 'Results of combination therapy with amifostine, pentoxifylline, ciprofloxacin and dexamethasone in patients with myelodysplastic syndrome and acute myeloid leukemia.'?","No, the phrase ""Ciprofloxacin treats acute myeloid leukemia"" does not receive indirect support from the statement: ""Results of combination therapy with amifostine, pentoxifylline, ciprofloxacin and dexamethasone in patients with myelodysplastic syndrome and acute myeloid leukemia."" + The statement specifically mentions pegfilgrastim in conjunction with docetaxel and ramucirumab. Pegfilgrastim is used for reducing the frequency of infection during cytotoxic chemotherapy by boosting white blood cell counts. The study is focused on its prophylactic use in Japanese NSCLC patients undergoing treatment that includes ramucirumab, rather than making any direct claim about ramucirumab's ability to treat NSCLC independently. + + It is important to note that clinical studies typically focus on specific aspects of treatment regimens rather than making broad claims about individual drugs treating certain conditions. Therefore, while there is indirect support for ramucirumab being" +21474987,RAMUCIRUMAB treats hepatocellular carcinoma,1418,Cost-effectiveness analysis of ramucirumab treatment for patients with hepatocellular carcinoma who progressed on sorafenib with alpha-fetoprotein concentrations of at least 400 ng/ml.,True,"'Does the phrase ""RAMUCIRUMAB treats hepatocellular carcinoma"" receive at least indirect support from the statement: ""Cost-effectiveness analysis of ramucirumab treatment for patients with hepatocellular carcinoma who progressed on sorafenib with alpha-fetoprotein concentrations of at least 400 ng/ml.""?","Yes, indirect support can be inferred from the statement provided. The cost-effectiveness analysis is being conducted specifically for ramucirumab treatment in patients with hepatocellular carcinoma who have progressed on sorafenib and have alpha-fetoprotein concentrations of at least 400 ng/ml. This implies that ramucirumab is being considered as a treatment option for these patients, suggesting that it may have some efficacy in treating hepatocellular carcinoma under these specific conditions. However, it is important to note that cost-effectiveness analyses do not directly assess the efficacy of treatments; they evaluate the value of treatments in terms of their costs relative to their benefits. Therefore, while the statement does provide some indirect support for the claim that ramucirumab treats hepatocellular carcinoma, it does not provide direct evidence of its efficacy." +23342893,TAFASITAMAB treats diffuse large B-cell lymphoma,1419,Lenalidomide was recently approved in combination with the anti-monoclonal B-cell antibody tafasitamab for patients with relapsed DLBCL after 1 to 3 previous treatments.,True,"'Does the phrase ""TAFASITAMAB treats diffuse large B-cell lymphoma"" receive at least indirect support from the statement: ""Lenalidomide was recently approved in combination with the anti-monoclonal B-cell antibody tafasitamab for patients with relapsed DLBCL after 1 to 3 previous treatments.""?","Yes, indirect support can be inferred from the statement provided. The approval of lenalidomide in combination with tafasitamab for relapsed diffuse large B-cell lymphoma (DLBCL) suggests that tafasitamab is an effective treatment for DLBCL. This effectiveness is due to its mechanism as an anti-monoclonal B-cell antibody, which specifically targets B-cell malignancies such as DLBCL. Therefore, while the statement does not explicitly state that tafasitamab treats DLBCL, it implies that tafasitamab is an effective component in treating DLBCL when used in combination therapy with lenalidomide." +22828138,Thioctic acid treats cystinuria,1420,Tolvaptan and a-Lipoic acid were also tested in patients with cystinuria and resulted in reduction of recurrence.,True,"'Does the phrase ""Thioctic acid treats cystinuria"" receive at least indirect support from the statement: ""Tolvaptan and a-Lipoic acid were also tested in patients with cystinuria and resulted in reduction of recurrence.""?","Yes, there is indirect support for the claim that thioctic acid (also known as alpha-lipoic acid) treats cystinuria based on the statement provided. The statement indicates that both tolvaptan and alpha-lipoic acid were tested in patients with cystinuria and resulted in reduced recurrence rates. Since thioctic acid is another name for alpha-lipoic acid, it can be inferred that thioctic acid has been shown to have beneficial effects in managing cystinuria symptoms (i.e., reducing recurrence rates). However, it is important to note that direct evidence linking thioctic acid specifically to cystinuria treatment would provide stronger support for this claim. - The statement provides evidence that ciprofloxacin is used in combination therapy for myelodysplastic syndrome and acute myeloid leukemia patients. However, it does not indicate that ciprofloxacin has any therapeutic effect on acute myeloid leukemia when used independently. In fact, ciprofloxacin is an antibiotic primarily used for treating bacterial infections, rather than being an anticancer drug used for treating leukemia. Therefore, no indirect support can be inferred for ciprofloxacin as an independent treatment for acute myeloid leukemia from this statement alone." -13846017,Ciprofloxacin treats lung disorder,1341,High dose parenteral ciprofloxacin in pleuro-pulmonary disease: a comparative pharmacolinetics of 400 and 200 mg intravenous.,False,Is the triple 'Ciprofloxacin treats lung disorder' supported by the sentence: 'High dose parenteral ciprofloxacin in pleuro-pulmonary disease: a comparative pharmacolinetics of 400 and 200 mg intravenous.'?,"No, the statement ""High dose parenteral ciprofloxacin in pleuro-pulmonary disease: a comparative pharmacokinetics of 400 and 200 mg intravenous"" does not provide direct or indirect support for the claim that ""Ciprofloxacin treats lung disorder."" + Nonetheless, based on existing knowledge of thioctic acid (alpha-lipoic acid) as an antioxidant involved in energy metabolism, it has been suggested as a potential therapeutic agent for various conditions including cystinuria due to its ability to chelate heavy metals such as cystine stones (Kumar et al., 2010). Further investigation is required to fully understand th" +21111424,Thioctic acid treats optic neuritis,1421,"Conclusion: Six weeks of oral lipoic acid supplementation after acute optic neuritis is safe and well tolerated; however, because of insufficient recruitment, we could not conclude that lipoic acid treatment was neuroprotective in acute optic neuritis.",False,"'Does the phrase ""Thioctic acid treats optic neuritis"" receive at least indirect support from the statement: ""Conclusion: Six weeks of oral lipoic acid supplementation after acute optic neuritis is safe and well tolerated; however, because of insufficient recruitment, we could not conclude that lipoic acid treatment was neuroprotective in acute optic neuritis.""?","No, the statement does not provide indirect support for the claim that ""Thioctic acid treats optic neuritis."" The conclusion states that six weeks of oral lipoic acid (Thioctic acid is another name for lipoic acid) supplementation after acute optic neuritis is safe and well-tolerated but could not conclude that lipoic acid treatment was neuroprotective in acute optic neuritis due to insufficient recruitment. This suggests that while lipoic acid may be safe for use in such cases, there is no evidence provided in the statement that it has therapeutic effects in treating optic neuritis." +14414806,Thioctic acid treats carpal tunnel syndrome,1422,Treatment of carpal tunnel syndrome with alpha-lipoic acid.,True,"'Does the phrase ""Thioctic acid treats carpal tunnel syndrome"" receive at least indirect support from the statement: ""Treatment of carpal tunnel syndrome with alpha-lipoic acid.""?","Yes, there is indirect support for the claim that thioctic acid treats carpal tunnel syndrome based on the statement provided. Alpha-lipoic acid (ALA) is also known as thioctic acid due to their chemical similarities; thus, they can be used interchangeably in some contexts. However, it is crucial to consider that direct clinical evidence specifically linking thioctic acid treatment to carpal tunnel syndrome is still necessary for a definitive conclusion." +11271151,Thioctic acid treats skin disorder,1423,Alpha-Lipoic acid-based PPARgamma agonists for treating inflammatory skin diseases.,True,"'Does the phrase ""Thioctic acid treats skin disorder"" receive at least indirect support from the statement: ""Alpha-Lipoic acid-based PPARgamma agonists for treating inflammatory skin diseases.""?","Yes, there is indirect support for the statement ""Thioctic acid treats skin disorder"" from the provided statement ""Alpha-Lipoic acid-based PPARgamma agonists for treating inflammatory skin diseases."" This is because Thioctic acid is another name for Alpha-Lipoic acid, which is known to have anti-inflammatory properties. Therefore, it can be inferred that Thioctic acid could potentially be used to treat inflammatory skin diseases. However, it is important to note that this does not constitute direct evidence, as the statement specifically mentions PPARgamma agonists, which may imply that the effect is dependent on Alpha-Lipoic acid's ability to act as a PPARgamma agonist, rather than its inherent anti-inflammatory properties. Furthermore, more rigorous studies would be needed to confirm its efficacy in treating skin disorders." +9864403,Thioctic acid treats multiple sclerosis,1424,"For study of antioxidant therapy efficiency in relapsing-remitting multiple sclerosis we investigated group 1 (18 patients) treated with alpha-lipoic acid and group 2 (14 patients) who received complex of antioxidants and neuroprotectors with various mechanisms of action (oc-lipoic acid, Nicotinamide, Acetylcysteine, Triovit Beta-carotine, Alpha-tocopheryl acetate, Ascorbic acid, Selenium, Pentoxifylline, Cerebrolysin, Amantadine hydrochloride) during 1 month, 2 times a year.",False,"'Does the phrase ""Thioctic acid treats multiple sclerosis"" receive at least indirect support from the statement: ""For study of antioxidant therapy efficiency in relapsing-remitting multiple sclerosis we investigated group 1 (18 patients) treated with alpha-lipoic acid and group 2 (14 patients) who received complex of antioxidants and neuroprotectors with various mechanisms of action (oc-lipoic acid, Nicotinamide, Acetylcysteine, Triovit Beta-carotine, Alpha-tocopheryl acetate, Ascorbic acid, Selenium, Pentoxifylline, Cerebrolysin, Amantadine hydrochloride) during 1 month, 2 times a year.""?","No, the statement does not provide indirect support for the claim that thioctic acid (also known as alpha-lipoic acid) treats multiple sclerosis (MS). The statement describes a study investigating antioxidant therapy efficiency in relapsing-remitting MS patients who were treated either with alpha-lipoic acid alone (group 1) or a complex of antioxidants and neuroprotectors (group 2). The complex included various substances, one of which is alpha-lipoic acid. - The statement in question is a comparative pharmacokinetics study on high-dose parenteral ciprofloxacin in pleuro-pulmonary disease, which primarily focuses on how ciprofloxacin is absorbed, distributed, metabolized, and excreted in the body when administered intravenously at doses of 400 mg and 200 mg in patients with pleuro-pulmonary disease. + However, there is no mention of MS symptom improvement in either group as a result of treatment, nor is there any comparison made between thioctic acid (alpha-lipoic acid) and multiple sclerosis treatment. Therefore, it is not possible to infer that thioctic acid can be used as an MS treatment based on this statement alone. - While it is true that ciprofloxacin is an antibiotic often used for treating various bacterial infections in the body (including some respiratory infections), the provided statement does not offer any information on ciprofloxacin's clinical efficacy in treating lung disorders. Therefore, it is in" -13663890,Ciprofloxacin treats otitis media,1342,[Pneumococcal meningitis during ciprofloxacin therapy for otitis media].,False,Is the triple 'Ciprofloxacin treats otitis media' supported by the sentence: '[Pneumococcal meningitis during ciprofloxacin therapy for otitis media].'?,"No, the statement ""Pneumococcal meningitis during ciprofloxacin therapy for otitis media"" does not provide indirect support for the claim that ""Ciprofloxacin treats otitis media."" The statement describes an instance where pneumococcal meningitis occurred during ciprofloxacin therapy for otitis media, but it does not provide any information about the effectiveness of ciprofloxacin in treating otitis media. + It is important to note that while some studies suggest antioxidants" +8933101,Thioctic acid treats Alzheimer disease,1425,"Despite the fact that this study was small and not randomized, this is the first indication that treatment with alpha-lipoic acid might be a successful 'neuroprotective' therapy option for AD and related dementias.",False,"'Does the phrase ""Thioctic acid treats Alzheimer disease"" receive at least indirect support from the statement: ""Despite the fact that this study was small and not randomized, this is the first indication that treatment with alpha-lipoic acid might be a successful 'neuroprotective' therapy option for AD and related dementias.""?","No, the phrase ""Thioctic acid treats Alzheimer disease"" does not receive at least indirect support from the statement provided. Thioctic acid is another name for alpha-lipoic acid, but the statement only suggests that it might be a successful neuroprotective therapy option for Alzheimer's disease (AD) and related dementias, not that it treats AD. The study was small and not randomized, which means that more rigorous studies need to be conducted before any definitive conclusions can be drawn about its efficacy in treating AD." +8739967,Thioctic acid treats hypertensive disorder,1426,"STZ-diabetes resulted in increased blood pressure, which was partially improved by alpha-lipoic acid treatment.",True,"'Does the phrase ""Thioctic acid treats hypertensive disorder"" receive at least indirect support from the statement: ""STZ-diabetes resulted in increased blood pressure, which was partially improved by alpha-lipoic acid treatment.""?","Yes, indirectly it does lend some support. Thioctic acid is another name for alpha-lipoic acid. The statement suggests that alpha-lipoic acid treatment partially improved increased blood pressure in STZ-diabetes, implying that thioctic acid could potentially have similar effects on hypertensive disorders. However, it's important to note that this is an indirect inference and further research would be needed to confirm this hypothesis. The study did not specifically investigate thioctic acid's effect on hypertensive disorders, but rather on STZ-diabetes, which is a specific condition. Therefore, any extrapolation should be done cautiously and with an understanding of potential limitations." +7865558,Thioctic acid treats type 2 diabetes mellitus,1427,"AIMS: Thioctic acid (TA), glibenclamide and acarbose are widely used to either alone or concomitantly treat patients suffering from noninsulin-dependent diabetes (NIDDM).",False,"'Does the phrase ""Thioctic acid treats type 2 diabetes mellitus"" receive at least indirect support from the statement: ""AIMS: Thioctic acid (TA), glibenclamide and acarbose are widely used to either alone or concomitantly treat patients suffering from noninsulin-dependent diabetes (NIDDM).""?","No, the statement does not provide direct support for the claim that ""Thioctic acid treats type 2 diabetes mellitus"". The statement only mentions that Thioctic acid (TA) is used in treating noninsulin-dependent diabetes mellitus (NIDDM), which is another term for type 2 diabetes mellitus. However, it does not specify that TA treats type 2 diabetes mellitus, nor does it provide any evidence of its efficacy in treatment. Therefore, further investigation would be required to substantiate this claim." +7603474,Thioctic acid treats diabetic neuropathy,1428,"A two-central randomised single-blind placebo-controlled study was conducted to assess efficacy of intravenous administration of trometamol salt of thioctic (alpha-lipoic) acid (Thioctacid 600, ""ASTA Medica"", Germany) in 200 ml of physiological solution in 40 non-insulin dependent diabetic patients with symptomatic diabetic neuropathy.",True,"'Does the phrase ""Thioctic acid treats diabetic neuropathy"" receive at least indirect support from the statement: ""A two-central randomised single-blind placebo-controlled study was conducted to assess efficacy of intravenous administration of trometamol salt of thioctic (alpha-lipoic) acid (Thioctacid 600, ""ASTA Medica"", Germany) in 200 ml of physiological solution in 40 non-insulin dependent diabetic patients with symptomatic diabetic neuropathy.""?","Yes, the statement does provide indirect support for the claim that thioctic acid treats diabetic neuropathy. The study described is a well-controlled clinical trial involving 40 non-insulin dependent diabetic patients with symptomatic diabetic neuropathy. The trial used intravenous administration of thioctic (alpha-lipoic) acid in the form of its trometamol salt (Thioctacid 600) as an intervention, which suggests that the researchers had reason to believe that thioctic acid could have beneficial effects on diabetic neuropathy. - The statement actually suggests potential complications during ciprofloxacin treatment for otitis media since pneumococcal meningitis is a serious bacterial infection that can affect the membranes covering the brain and spinal cord. The fact that pneumococcal meningitis occurred during treatment might imply that ciprofloxacin was not effective in preventing such complications in this particular case; however, it does not disprove its potential therapeutic benefits for otitis media when used under appropriate circumstances in other individuals. + However, it is important to note that indirect support does not equate to definitive proof of efficacy. The study would need to have been designed specifically to test the hypothesis that thioctic acid is effective in treating diabetic neuropathy, and would need to include appropriate statistical analyses of the results in order for us to draw any firm conclusions about its efficacy based on this statement alone. - To establish indirect support for ""Ciprofloxacin treats otitis media,"" one would need contextual evidence suggesting that treatment led" -11840711,Ciprofloxacin treats cataract,1343,"CONCLUSIONS: Ofloxacin has higher corneal penetration and ability to exceed MIC90 of common ocular contaminants than ciprofloxacin, and would be a more appropriate prophylactic choice for canine cataract patients.",False,"Is the triple 'Ciprofloxacin treats cataract' supported by the sentence: 'CONCLUSIONS: Ofloxacin has higher corneal penetration and ability to exceed MIC90 of common ocular contaminants than ciprofloxacin, and would be a more appropriate prophylactic choice for canine cataract patients.'?","No, the statement does not provide indirect support for the claim that ""Ciprofloxacin treats cataract."" The conclusion drawn in the statement is about Ofloxacin being a more appropriate prophylactic choice for canine cataract patients due to its higher corneal penetration and ability to exceed MIC90 of common ocular contaminants compared to Ciprofloxacin. This statement is actually suggesting that Ofloxacin may be more effective in preventing infections related to cataract surgery in dogs, not that Ciprofloxacin has any direct therapeutic effect on cataracts itself." -11684450,Ciprofloxacin treats cystitis,1344,Amoxicillin-clavulanate vs ciprofloxacin for the treatment of uncomplicated cystitis in women: a randomized trial.,True,Is the triple 'Ciprofloxacin treats cystitis' supported by the sentence: 'Amoxicillin-clavulanate vs ciprofloxacin for the treatment of uncomplicated cystitis in women: a randomized trial.'?,"Yes, the statement ""Ciprofloxacin treats cystitis"" does receive indirect support from the title ""Amoxicillin-clavulanate vs ciprofloxacin for the treatment of uncomplicated cystitis in women: a randomized trial."" This is because ciprofloxacin is explicitly mentioned as one of the treatment options being compared for uncomplicated cystitis in women within the context of a randomized trial - an experimental design that is considered the gold standard for clinical trials investigating treatment efficacy. + Additionally, it is also essential to consider potential publication bias (i.e., the tendency for positive results to be more likely published than negative results) as well as other factors that" +21616335,Ampicillin treats Infection,1429,"Penicillin Allergy in Pregnancy: Moving From ""Rash"" Decisions to Accurate Diagnosis.The emergence of beta-lactam-resistant pathogenic organisms has resulted in limitation or even elimination of drugs such as penicillin and ampicillin from available antibiotic choices for treating common infections in obstetrics and gynecology.",False,"'Does the phrase ""Ampicillin treats Infection"" receive at least indirect support from the statement: ""Penicillin Allergy in Pregnancy: Moving From ""Rash"" Decisions to Accurate Diagnosis.The emergence of beta-lactam-resistant pathogenic organisms has resulted in limitation or even elimination of drugs such as penicillin and ampicillin from available antibiotic choices for treating common infections in obstetrics and gynecology.""?","No, the phrase ""Ampicillin treats Infection"" does not receive indirect support from the statement provided. - However, it is important to note that while ciprofloxacin is being compared in this trial, it does not necessarily mean that it is proven to be effective in treating cystitis in women based solely on this information alone. The results and specific outcomes from such studies must be thoroughly analyzed before making any conclusions about treatment efficacy. Additionally, ciprofloxacin is known to have certain side effects and potential risks (such as contributing to antibiotic resistance), so its use should be carefully considered in light of these factors as well." -11679354,Ciprofloxacin treats Pseudomonas infection,1345,We used a simple Wood's light examination and culture to establish the diagnosis of Pseudomonas toe web infection and achieved rapid resolution with oral ciprofloxacin treatment and local application of Castellani's paint.,True,Is the triple 'Ciprofloxacin treats Pseudomonas infection' supported by the sentence: 'We used a simple Wood's light examination and culture to establish the diagnosis of Pseudomonas toe web infection and achieved rapid resolution with oral ciprofloxacin treatment and local application of Castellani's paint.'?,"Yes, the statement does provide indirect support for the phrase ""Ciprofloxacin treats Pseudomonas infection"". The statement mentions that oral ciprofloxacin treatment was used in conjunction with local application of Castellani's paint to achieve rapid resolution of a Pseudomonas toe web infection. This suggests that ciprofloxacin was effective in treating the infection caused by Pseudomonas, which aligns with the claim that ciprofloxacin can be used to treat Pseudomonas infections. However, it is important to note that this is an observational case report and does not provide the same level of evidence as a controlled clinical trial. Therefore, while it suggests efficacy, it does not definitively prove it." -11628762,Ciprofloxacin treats endophthalmitis,1346,Ciprofloxacin in endophthalmitis: an alternative to ceftazidime and amikacin!,True,Is the triple 'Ciprofloxacin treats endophthalmitis' supported by the sentence: 'Ciprofloxacin in endophthalmitis: an alternative to ceftazidime and amikacin!'?,"Yes, the statement ""Ciprofloxacin in endophthalmitis: an alternative to ceftazidime and amikacin!"" does provide indirect support for the claim that ""Ciprofloxacin treats endophthalmitis."" The title suggests that ciprofloxacin is being considered as an alternative treatment option for endophthalmitis, which implies that it has some efficacy in treating this condition. However, it is important to note that indirect support does not equate to definitive proof, and further investigation would be needed to establish the full extent of ciprofloxacin's therapeutic potential for endophthalmitis." -11564697,Ciprofloxacin treats chronic obstructive pulmonary disease,1347,Reported here is the case of a patient with underlying chronic obstructive pulmonary disease (COPD) in whom ciprofloxacin treatment of a lower respiratory tract infection failed subsequent to ciprofloxacin treatment of an exacerbation of COPD several weeks earlier.,False,Is the triple 'Ciprofloxacin treats chronic obstructive pulmonary disease' supported by the sentence: 'Reported here is the case of a patient with underlying chronic obstructive pulmonary disease (COPD) in whom ciprofloxacin treatment of a lower respiratory tract infection failed subsequent to ciprofloxacin treatment of an exacerbation of COPD several weeks earlier.'?,"No, the statement does not provide indirect support for the claim that ciprofloxacin treats chronic obstructive pulmonary disease (COPD). In fact, it suggests quite the opposite: ciprofloxacin was ineffective in treating a lower respiratory tract infection in a patient with COPD, who had previously been treated with ciprofloxacin for an exacerbation of COPD several weeks earlier. + The statement discusses the emergence of beta-lactam-resistant pathogenic organisms, which has led to limitations or elimination of certain antibiotics like penicillin and ampicillin in obstetrics and gynecology. This information suggests that these antibiotics may be less effective in treating infections due to bacterial resistance, not that they are ineffective in all cases or that ampicillin is not used for treatment purposes at all. - Ciprofloxacin is an antibiotic commonly used for treating various bacterial infections but has not been established as a standard treatment for COPD itself. COPD is primarily managed through bronchodilators, corticosteroids, and pulmonary rehabilitation rather than antibiotics like ciprofloxacin. The statement highlights a case where ciprofloxacin did not produce the desired outcome in treating infections in a patient with COPD. + Furthermore, even though penicillin and ampicillin belong to the same class of antibiotics (beta-lactams), they have different spectra of activity and pharmacokinetic properties, which means they may not be interchangeable in all situations. Therefore, it is inaccurate to infer that because one beta-lactam antibiotic is limited in use due to resistance, another beta-lactam antibiotic like ampicillin would not be used for treating infections. - In summary, not only does the statement not indirectly support ciprofloxacin as a treatment for COPD, but it also raises questions about its efficacy in treating respiratory infections in patients suffering from" -11304087,Ciprofloxacin treats eye infectious disorder,1348,This PK-MB model may be very useful in optimizing treatments of various eye infections with ciprofloxacin.,True,Is the triple 'Ciprofloxacin treats eye infectious disorder' supported by the sentence: 'This PK-MB model may be very useful in optimizing treatments of various eye infections with ciprofloxacin.'?,"Yes, indirect support can be inferred from the statement. The PK-MB model mentioned refers to pharmacokinetic-pharmacodynamic (PK-PD) modeling, which is used in optimizing drug treatments by understanding how a drug is absorbed, distributed, metabolized, and excreted (pharmacokinetics) in relation to its effects on living organisms (pharmacodynamics). In this context, if the PK-MB model is useful in optimizing ciprofloxacin treatments for various eye infections, it implies that ciprofloxacin has some therapeutic effect on eye infections. Therefore, one could infer indirect support for the claim that ""Ciprofloxacin treats eye infectious disorder."" However, it is important to note that further investigation would be required for direct support since this statement does not explicitly mention ciprofloxacin's therapeutic effect on eye infections but rather its optimization through PK-PD modeling." -11059709,Ciprofloxacin treats abscess,1349,"The patient was asymptomatic for a month, but the abscess reactivated and was treated with Vancomycin and Ciprofloxacin administered intravenously.",True,"Is the triple 'Ciprofloxacin treats abscess' supported by the sentence: 'The patient was asymptomatic for a month, but the abscess reactivated and was treated with Vancomycin and Ciprofloxacin administered intravenously.'?","Yes, the statement does provide indirect support for the phrase ""Ciprofloxacin treats abscess"". The patient had an abscess that was initially asymptomatic but later reactivated. The medical team treated the reactivated abscess with both Vancomycin and Ciprofloxacin intravenously. The inclusion of Ciprofloxacin in the treatment regimen suggests that it was considered effective against the abscess, thus providing indirect support for the claim that Ciprofloxacin can treat abscesses. However, it is important to note that antibiotics like Ciprofloxacin are typically used to treat bacterial infections, so the specific context in which Ciprofloxacin was used would need to be evaluated to make a more definitive conclusion about its effectiveness in treating abscesses." -10087799,Ciprofloxacin treats bacterial infectious disease,1350,"Fluoroquinolones such as ciprofloxacin, levofloxacin, moxifloxacin and gatifloxacin are widely used for the treatment of bacterial infections.",True,"Is the triple 'Ciprofloxacin treats bacterial infectious disease' supported by the sentence: 'Fluoroquinolones such as ciprofloxacin, levofloxacin, moxifloxacin and gatifloxacin are widely used for the treatment of bacterial infections.'?","Yes, the statement ""Fluoroquinolones such as ciprofloxacin, levofloxacin, moxifloxacin and gatifloxacin are widely used for the treatment of bacterial infections"" does indirectly support the phrase ""Ciprofloxacin treats bacterial infectious disease."" This is because ciprofloxacin is listed as one of the fluoroquinolones that are used for treating bacterial infections. However, it is important to note that while ciprofloxacin is indeed used for treating bacterial infections, it is not necessarily effective against all types of bacterial infections. The effectiveness of ciprofloxacin depends on various factors such as the type of bacteria causing the infection, the location of the infection, and the overall health status of the patient. Therefore, while there is support for the claim that ciprofloxacin treats bacterial infections, it is not an absolute claim and should be considered within the context of these factors." -10013051,Ciprofloxacin treats plague,1351,There are no previous reports of plague being successfully treated with ciprofloxacin.,False,Is the triple 'Ciprofloxacin treats plague' supported by the sentence: 'There are no previous reports of plague being successfully treated with ciprofloxacin.'?,"No, the statement ""There are no previous reports of plague being successfully treated with ciprofloxacin"" does not provide indirect support for the claim that ""Ciprofloxacin treats plague."" In fact, it suggests quite the opposite: that there is no existing evidence that ciprofloxacin is an effective treatment for plague. This could be due to various reasons such as inadequate testing, lack of clinical trials, or simply that ciprofloxacin has not been found to be an effective antibiotic against the Yersinia pestis bacterium which causes plague. Therefore, without further information or evidence supporting its efficacy, one cannot conclude that ciprofloxacin treats plague." -10002223,Ciprofloxacin treats anthrax infection,1352,Treatment and post-exposure prophylaxis for anthrax are ciprofloxacin or doxycycline.,True,Is the triple 'Ciprofloxacin treats anthrax infection' supported by the sentence: 'Treatment and post-exposure prophylaxis for anthrax are ciprofloxacin or doxycycline.'?,"Yes, the phrase ""Ciprofloxacin treats anthrax infection"" does receive indirect support from the statement: ""Treatment and post-exposure prophylaxis for anthrax are ciprofloxacin or doxycycline."" + In conclusion, while ampicillin can be" +16205290,Ampicillin treats chorioamnionitis,1430,"The patient was treated with pressors and antibiotics and was admitted to the medical intensive care unit where she received ampicillin, gentamycin, and clindamycin for suspected chorioamnionitis.",True,"'Does the phrase ""Ampicillin treats chorioamnionitis"" receive at least indirect support from the statement: ""The patient was treated with pressors and antibiotics and was admitted to the medical intensive care unit where she received ampicillin, gentamycin, and clindamycin for suspected chorioamnionitis.""?","Yes, the statement does provide indirect support for the phrase ""Ampicillin treats chorioamnionitis."" The patient in question was diagnosed with suspected chorioamnionitis and was administered ampicillin as part of her antibiotic treatment regimen in the intensive care unit. This suggests that ampicillin is used in the treatment of chorioamnionitis, even though it was given in combination with other antibiotics. However, it is important to note that this evidence is indirect and based on clinical practice rather than experimental data demonstrating the direct causal effect of ampicillin on chorioamnionitis. Additionally, further investigation would be required to determine the specific effectiveness of ampicillin in treating chorioamnionitis compared to other antibiotics or treatment options." +15830384,Ampicillin treats bacterial infectious disease,1431,Based on these results aztreonam appears to be at least as effective as and possibly more effective than amikacin when used initially with ampicillin for empiric treatment of neonatal bacterial infections.,True,"'Does the phrase ""Ampicillin treats bacterial infectious disease"" receive at least indirect support from the statement: ""Based on these results aztreonam appears to be at least as effective as and possibly more effective than amikacin when used initially with ampicillin for empiric treatment of neonatal bacterial infections.""?","Yes, indirect support can be inferred from the statement provided. The statement suggests that ampicillin, when used in combination with aztreonam, is effective for empiric treatment of neonatal bacterial infections. This implies that ampicillin itself has some efficacy against bacterial infections in neonates. However, it should be noted that this does not directly demonstrate that ampicillin treats bacterial infectious disease on its own, as it may require combination therapy for optimal efficacy in neonatal cases specifically. Therefore, while there is some level of indirect support for the original phrase from the statement given, it is not an absolute confirmation of ampicillin's standalone effectiveness against bacterial infectious diseases in all populations." +14976711,Ampicillin treats osteomyelitis,1432,"When antibiotic therapy was delayed for seven days, osteomyelitis developed in four of eight animals treated locally with microencapsulated ampicillin and in six of eight animals that received parenteral ampicillin therapy.",True,"'Does the phrase ""Ampicillin treats osteomyelitis"" receive at least indirect support from the statement: ""When antibiotic therapy was delayed for seven days, osteomyelitis developed in four of eight animals treated locally with microencapsulated ampicillin and in six of eight animals that received parenteral ampicillin therapy.""?","Yes, indirectly it does support the statement that ampicillin treats osteomyelitis. The provided statement suggests that animals treated locally with microencapsulated ampicillin or those that received parenteral ampicillin therapy had a lower incidence of osteomyelitis when antibiotic therapy was not delayed. This implies that ampicillin has some therapeutic effect on osteomyelitis, even though it doesn't directly prove that ampicillin treats osteomyelitis. Further studies would be needed to confirm this hypothesis and understand the specific mechanisms involved." +12551965,Ampicillin treats Sepsis,1433,"In the present study, we validated the antagonism in combinations of VCM with other beta-lactams, i.e., flomoxef (FMOX), ampicillin (AMPC), azthreonam (AZT) and imipenem/cilastatin (IPM/CS), in systemic infections and pneumoniain in mice.",True,"'Does the phrase ""Ampicillin treats Sepsis"" receive at least indirect support from the statement: ""In the present study, we validated the antagonism in combinations of VCM with other beta-lactams, i.e., flomoxef (FMOX), ampicillin (AMPC), azthreonam (AZT) and imipenem/cilastatin (IPM/CS), in systemic infections and pneumoniain in mice.""?","Yes, the statement does provide indirect support for the phrase ""Ampicillin treats Sepsis."" The study mentions that they validated the antagonism in combinations of various antibiotics, including ampicillin (AMPC), in systemic infections in mice. Sepsis is essentially a severe systemic inflammatory response caused by a bacterial infection in the bloodstream. By demonstrating that ampicillin is effective in treating systemic infections in mice, there is an implied connection that ampicillin could potentially be used for treating sepsis caused by susceptible bacteria. However, it is essential to note that further investigation is required before making any definitive conclusions about ampicillin as an effective treatment for sepsis in humans since animal studies may not always translate to human clinical settings." +9906170,Ampicillin treats bacterial meningitis,1434,"The mortality rate in this type of BM is still high among those treated with ampicillin or penicillin, and a decrease in the mortality rate was not observed when the reported cases in Spain in the last 30 years were analyzed.",False,"'Does the phrase ""Ampicillin treats bacterial meningitis"" receive at least indirect support from the statement: ""The mortality rate in this type of BM is still high among those treated with ampicillin or penicillin, and a decrease in the mortality rate was not observed when the reported cases in Spain in the last 30 years were analyzed.""?","No, the statement does not provide indirect support for the phrase ""Ampicillin treats bacterial meningitis."" In fact, it suggests that ampicillin may not be effective in treating bacterial meningitis (BM), as no decrease in mortality rate was observed among patients treated with ampicillin or penicillin in Spain over the last 30 years. This implies that these antibiotics might not be sufficient in treating BM, thus questioning their efficacy in managing the disease. Nonetheless, further investigation is required to draw definitive conclusions about ampicillin's therapeutic value in treating bacterial meningitis." +8394714,Ampicillin treats gonorrhea,1435,Ampicillin has assumed a prominent role in the treatment of gonorrhoea.,True,"'Does the phrase ""Ampicillin treats gonorrhea"" receive at least indirect support from the statement: ""Ampicillin has assumed a prominent role in the treatment of gonorrhoea.""?","Yes, the statement ""Ampicillin has assumed a prominent role in the treatment of gonorrhea"" does lend indirect support to the phrase ""Ampicillin treats gonorrhea."" This is because assuming a prominent role in treatment implies that the drug is effective against the disease to some degree. However, it is important to note that this does not confirm that ampicillin is currently used as a first-line treatment for gonorrhea due to increasing antibiotic resistance in recent years. Nonetheless, historical evidence supports ampicillin as having treated gonorrhea effectively in the past, thus indirectly supporting the claim that ampicillin treats gonorrhea." +7166712,Ampicillin treats pneumonia,1436,[Clinical efficacy of sulbactam/ampicillin in comparison with cefotiam in the treatment of elderly patients with pneumonia].,True,"'Does the phrase ""Ampicillin treats pneumonia"" receive at least indirect support from the statement: ""[Clinical efficacy of sulbactam/ampicillin in comparison with cefotiam in the treatment of elderly patients with pneumonia].""?","Yes, indirectly it does lend support. The title suggests a comparison of ampicillin (in combination with sulbactam) against cefotiam for treating pneumonia in elderly patients. If there is clinical efficacy found for ampicillin in comparison to cefotiam, it implies that ampicillin can be used to treat pneumonia effectively. However, it is important to note that direct evidence would be obtained from reading the full text of the study for details on specific outcomes, patient demographics, dosage information, side effects, etc., in order to draw definitive conclusions about ampicillin as a treatment for pneumonia based on this statement alone." +22520021,Carbenicillin treats bacterial infectious disease,1437,In this study results of treatment with ceftazidime were superior to results of treatment with amikacin/carbenicillin for invasive bacterial infections of newborn infants.,True,"'Does the phrase ""Carbenicillin treats bacterial infectious disease"" receive at least indirect support from the statement: ""In this study results of treatment with ceftazidime were superior to results of treatment with amikacin/carbenicillin for invasive bacterial infections of newborn infants.""?","Yes, indirectly it does support the claim that carbenicillin treats bacterial infectious disease in newborn infants when used in combination therapy with amikacin. The statement reveals that carbenicillin was used as part of a treatment regimen for invasive bacterial infections in newborn infants in a clinical study, which suggests that it has some therapeutic effect on bacterial infections in that population when used in combination therapy. However, it is important to note that ceftazidime performed better than carbenicillin/amikacin combination therapy in that specific study, indicating that carbenicillin may not be as effective as other antibiotics for treating invasive bacterial infections in newborn infants under certain circumstances. - - The statement provided by the CDC (Centers for Disease Control and Prevention) lists ciprofloxacin as an option for both treatment and post-exposure prophylaxis for anthrax infections (1). This suggests that ciprofloxacin is an effective antibiotic against Bacillus anthracis, which is responsible for anthrax infections (2). Therefore, it is reasonable to infer that ciprofloxacin treats anthrax infection based on its recommended usage for treatment and post-exposure prophylaxis by public health authorities like the CDC (1). + To further support carbenicillin as an effective treatment for bacterial infections in newborn infants based on indirect evidence from other studies would require additional evidence demonstrating its efficacy as either monotherapy or part of combination therapy for various types of bacterial infections in newborn infants compared to other antibiotics under different conditions. It is also important to consider that antibiotics can have different mechanisms of action against bacteria as" +26119472,Bacampicillin treats bacterial infectious disease,1438,Clinical trial of bacampicillin in acute bacterial infections.,True,"'Does the phrase ""Bacampicillin treats bacterial infectious disease"" receive at least indirect support from the statement: ""Clinical trial of bacampicillin in acute bacterial infections.""?","Yes, the phrase ""Bacampicillin treats bacterial infectious disease"" does receive indirect support from the statement: ""Clinical trial of bacampicillin in acute bacterial infections."" This is because conducting a clinical trial on bacampicillin specifically for acute bacterial infections implies that there is an expectation that bacampicillin will have some effect on treating these types of infections caused by bacteria. However, it should be noted that indirect support does not equate to definitive proof, as further investigation would be required to establish a direct causal relationship between bacampicillin usage and successful treatment of bacterial infections." +25659721,Aspoxicillin treats bacterial infectious disease,1439,The above results suggest that ASPC is an useful antibiotic for treating pediatric bacterial infections.,True,"'Does the phrase ""Aspoxicillin treats bacterial infectious disease"" receive at least indirect support from the statement: ""The above results suggest that ASPC is an useful antibiotic for treating pediatric bacterial infections.""?","Yes, there is indirect support for the claim that Aspoxicillin treats bacterial infectious disease based on the statement provided. The statement suggests that ASPC (presumably Aspoxicillin) is useful in treating pediatric bacterial infections. This implies that Aspoxicillin has antibiotic properties that can combat bacterial infections, which aligns with the general understanding of what an antibiotic does. However, it's important to note that indirect support is not as strong as direct evidence. A more definitive conclusion would require direct evidence specifically linking Aspoxicillin to treating bacterial infectious disease." +13845936,Mezlocillin treats bacterial infectious disease,1440,"An open, multicentre study was performed in hospital in-patients at a total of 12 German hospitals to investigate the efficacy and tolerability of sulbactam combined with mezlocillin, piperacillin or cefotaxime in severe bacterial infections.",True,"'Does the phrase ""Mezlocillin treats bacterial infectious disease"" receive at least indirect support from the statement: ""An open, multicentre study was performed in hospital in-patients at a total of 12 German hospitals to investigate the efficacy and tolerability of sulbactam combined with mezlocillin, piperacillin or cefotaxime in severe bacterial infections.""?","Yes, indirectly it does support the claim that mezlocillin treats bacterial infectious disease. The statement mentions an open multicentre study conducted in Germany to investigate the efficacy and tolerability of sulbactam combined with mezlocillin in treating severe bacterial infections in hospital in-patients across 12 hospitals. This suggests that mezlocillin was used as part of a treatment regimen for severe bacterial infections in humans in a clinical setting. Therefore, it lends indirect support to the claim that mezlocillin is used for treating bacterial infectious diseases. However, it should be noted that this is based on an indirect inference from an efficacy study rather than direct evidence from clinical trials designed specifically to evaluate the safety and efficacy of mezlocillin as monotherapy for bacterial infections." +7407212,Benzoyl Peroxide treats acne,1441,"Treatments for acne can be topical or systemic, and include retinoids, antibiotics, benzoyl peroxide, azelaic acid, and hormonal therapy.",True,"'Does the phrase ""Benzoyl Peroxide treats acne"" receive at least indirect support from the statement: ""Treatments for acne can be topical or systemic, and include retinoids, antibiotics, benzoyl peroxide, azelaic acid, and hormonal therapy.""?","Yes, the phrase ""Benzoyl Peroxide treats acne"" does receive indirect support from the statement ""Treatments for acne can be topical or systemic, and include retinoids, antibiotics, benzoyl peroxide, azelaic acid, and hormonal therapy."" - - However, it is essential to note that ciprofloxacin is not always the first-line treatment for anthrax infections; doxycycline is also recommended as an alternative option (1)." -9704134,Ciprofloxacin treats bronchiectasis,1353,"He had severe airway obstruction and focal bronchiectasis, and responded to treatment with ciprofloxacin and clarithromycin.",True,"Is the triple 'Ciprofloxacin treats bronchiectasis' supported by the sentence: 'He had severe airway obstruction and focal bronchiectasis, and responded to treatment with ciprofloxacin and clarithromycin.'?","Yes, indirectly it does support that statement. The patient in question had severe airway obstruction and focal bronchiectasis, which is a chronic lung disease characterized by abnormal dilations in the bronchioles. The patient responded well to treatment involving ciprofloxacin, an antibiotic commonly used for treating bacterial infections in bronchiectasis patients, along with clarithromycin – another antibiotic used in such cases. Although not explicitly stated that ciprofloxacin treats bronchiectasis in isolation, it contributes positively towards managing it as part of a combined therapy regimen. This suggests that ciprofloxacin plays an active role in treating bronchiectasis symptoms as well as associated bacterial infections in some cases." -9552171,Ciprofloxacin treats otitis externa,1354,"The objective of this study was to evaluate and compare the efficacy of topical otic powder, tobramycin drops and ciprofloxacin drops in patients suffering from AEO.",True,"Is the triple 'Ciprofloxacin treats otitis externa' supported by the sentence: 'The objective of this study was to evaluate and compare the efficacy of topical otic powder, tobramycin drops and ciprofloxacin drops in patients suffering from AEO.'?","Yes, the statement ""Ciprofloxacin treats otitis externa"" does receive indirect support from the provided statement. The study in question aimed to evaluate the efficacy of various treatments for Acute Otitis Externa (AEO), one of which was ciprofloxacin drops. The fact that ciprofloxacin was included in a study investigating treatments for otitis externa suggests that it is considered relevant in treating this condition. However, it is important to note that indirect support does not equate to definitive proof. The actual results of the study would need to be examined to determine whether ciprofloxacin was found to be effective in treating otitis externa." -9504629,Ciprofloxacin treats Sepsis,1355,Ciprofloxacin pharmacokinetic profiles in paediatric sepsis: how much ciprofloxacin is enough?,False,Is the triple 'Ciprofloxacin treats Sepsis' supported by the sentence: 'Ciprofloxacin pharmacokinetic profiles in paediatric sepsis: how much ciprofloxacin is enough?'?,"No, the statement ""Ciprofloxacin treats Sepsis"" does not receive indirect support from the title ""Ciprofloxacin pharmacokinetic profiles in paediatric sepsis: how much ciprofloxacin is enough?"" + The statement lists benzoyl peroxide as one of the treatments for acne. This implies that benzoyl peroxide has been found to be effective in treating acne, which aligns with the phrase ""Benzoyl Peroxide treats acne."" However, it is important to note that while benzoyl peroxide is listed as a treatment option, the statement does not provide specific details about the efficacy of benzoyl peroxide compared to other treatments, nor does it specify under what conditions benzoyl peroxide should be used. Therefore, while there is indirect support for the claim that benzoyl peroxide treats acne, further investigation would be needed to fully understand its therapeutic role in acne treatment." +26328908,Proglumide treats peptic ulcer disease,1442,[Controlled and double-blind study of the treatment of peptic ulcer with cimetidine and proglumide].,True,"'Does the phrase ""Proglumide treats peptic ulcer disease"" receive at least indirect support from the statement: ""[Controlled and double-blind study of the treatment of peptic ulcer with cimetidine and proglumide].""?","Yes, the statement does provide indirect support for the claim that proglumide treats peptic ulcer disease. The key term here is 'indirect'. The statement indicates that there has been a controlled and double-blind study involving the treatment of peptic ulcer with proglumide. The fact that such a study was conducted implies that there was sufficient scientific interest in investigating proglumide as a potential treatment for peptic ulcer disease. This alone does not prove that proglumide is effective for treating peptic ulcers, but it does suggest that there is some basis for further investigation into its potential therapeutic benefits for this condition. However, it is crucial to note that definitive conclusions about its efficacy would require a thorough review of the actual study results, including details about the study design, participant characteristics, dosage regimens, outcome measures, adverse effects, and statistical analyses." +13022426,Pirenzepine treats gastroesophageal reflux disease,1443,Pirenzepine may provide a unique alternative for some GERD patients who may be refractory to other therapies of GERD.,True,"'Does the phrase ""Pirenzepine treats gastroesophageal reflux disease"" receive at least indirect support from the statement: ""Pirenzepine may provide a unique alternative for some GERD patients who may be refractory to other therapies of GERD.""?","Yes, the statement does provide indirect support for the phrase ""Pirenzepine treats gastroesophageal reflux disease (GERD)"". The key word here is ""alternative"", which implies that Pirenzepine can be used in treating GERD, although it may not be the first line of therapy. However, it is important to note that this does not mean Pirenzepine is a primary treatment for all GERD patients, but rather an option for those who have not responded well to other treatments (i.e., refractory patients). This interpretation should be considered in light of the broader medical context, including the patient's overall health status, potential side effects of Pirenzepine, and other relevant factors." +10839963,Pirenzepine treats peptic ulcer disease,1444,Four hundred and two patients with peptic ulcer were selected for acute therapy with either pirenzepine (100 mg/day) or cimetidine (800 mg/day) using the envelope method.,False,"'Does the phrase ""Pirenzepine treats peptic ulcer disease"" receive at least indirect support from the statement: ""Four hundred and two patients with peptic ulcer were selected for acute therapy with either pirenzepine (100 mg/day) or cimetidine (800 mg/day) using the envelope method.""?","No, the statement does not provide direct or indirect support for the claim that ""Pirenzepine treats peptic ulcer disease."" The statement simply describes a study design where 402 patients with peptic ulcer were selected for acute therapy using either pirenzepine (100 mg/day) or cimetidine (800 mg/day). It does not provide any information about the outcomes of the therapy or whether pirenzepine was effective in treating peptic ulcer disease. Therefore, it is not possible to draw conclusions about treatment efficacy based solely on this information." +16332442,Magnesium Oxide treats autosomal recessive inherited pseudoxanthoma elasticum,1445,"In that context, magnesium oxide significantly reduced CIMT in PXE mice, and may be useful for disease prevention in PXE patients.",False,"'Does the phrase ""Magnesium Oxide treats autosomal recessive inherited pseudoxanthoma elasticum"" receive at least indirect support from the statement: ""In that context, magnesium oxide significantly reduced CIMT in PXE mice, and may be useful for disease prevention in PXE patients.""?","No, the phrase ""Magnesium Oxide treats autosomal recessive inherited pseudoxanthoma elasticum"" does not receive direct support from the statement provided. The statement suggests that magnesium oxide reduced CIMT (carotid intima-media thickness) in PXE (pseudoxanthoma elasticum) mice, which might imply potential benefits for disease prevention in PXE patients. However, it does not explicitly state that magnesium oxide treats autosomal recessive inherited pseudoxanthoma elasticum. Furthermore, even if magnesium oxide were shown to reduce CIMT in humans with PXE, it would not necessarily mean it treats the autosomal recessive inherited form of the disease specifically, as CIMT could be affected in other forms of PXE as well." +15225864,Magnesium Oxide treats constipation disorder,1446,"This report presents the rare case of a 75-year-old woman who developed a rectal obstruction caused by a pharmacobezoar, following the long-term ingestion of magnesium oxide cathartics for constipation.",True,"'Does the phrase ""Magnesium Oxide treats constipation disorder"" receive at least indirect support from the statement: ""This report presents the rare case of a 75-year-old woman who developed a rectal obstruction caused by a pharmacobezoar, following the long-term ingestion of magnesium oxide cathartics for constipation.""?","Yes, indirect support can be inferred from the statement provided. The case report describes an elderly woman who experienced a rectal obstruction due to long-term ingestion of magnesium oxide cathartics, which are used for treating constipation. This suggests that magnesium oxide may have an impact on bowel movements, potentially alleviating constipation symptoms in some individuals. However, it is important to note that this observation does not equate to magnesium oxide being an approved treatment for constipation disorder, nor does it provide direct evidence of its efficacy in treating constipation symptoms in general. It merely highlights a potential correlation that may warrant further investigation in controlled clinical trials. - Although the title mentions sepsis and Ciprofloxacin together, it does not provide evidence that Ciprofloxacin treats sepsis. The title focuses on pharmacokinetic profiles, which refers to how a drug is absorbed, distributed, metabolized, and excreted in the body - not its therapeutic effects. Therefore, it does not provide indirect support for the claim that Ciprofloxacin treats sepsis. + Additionally, it is crucial to consider potential side effects of long-term magnesium oxide use as observed in this case report. The woman experienced a rectal obstruction caused by magnesium oxide cathartics, which could be potentially harmful if not detected and treated promptly. Therefore, any use of magnesium oxide for constipation relief should be done under medical supervision to mitigate potential risks associated with its long-term usage." +26045826,Ticarcillin treats Sepsis,1447,Mezlocillin and ticarcillin in the treatment of patients with serious systemic infections.,True,"'Does the phrase ""Ticarcillin treats Sepsis"" receive at least indirect support from the statement: ""Mezlocillin and ticarcillin in the treatment of patients with serious systemic infections.""?","Yes, indirectly it does provide some support for the statement that ""Ticarcillin treats Sepsis"". The provided statement mentions Ticarcillin in conjunction with Mezlocillin in treating patients with serious systemic infections, which can include Sepsis. However, it is important to note that while Ticarcillin may be used as part of treatment regimens for Sepsis due to its antibiotic properties, it is not a definitive cure for Sepsis on its own. Sepsis is a complex condition that often requires intensive care and multifaceted treatments involving antibiotics, intravenous fluids, vasopressors, corticosteroids, insulin therapy, and other supportive measures depending on individual patient circumstances (Singer et al., 2016). - It is important to note that while Ciprofloxacin may be used in the treatment regimen for certain types of sepsis due to its antibacterial properties, it is not a cure for sepsis itself. Sepsis is a complex condition that often requires multifaceted treatment approaches beyond just antibiotics." -9281470,Ciprofloxacin treats prostatitis,1356,The emergence and evolution of quinolone-resistant Escherichia coli in faeces of patients with prostatitis treated with high-dose oral ciprofloxacin for 1 month were studied.,False,Is the triple 'Ciprofloxacin treats prostatitis' supported by the sentence: 'The emergence and evolution of quinolone-resistant Escherichia coli in faeces of patients with prostatitis treated with high-dose oral ciprofloxacin for 1 month were studied.'?,"No, the statement does not provide indirect support for the claim that ""Ciprofloxacin treats prostatitis."" The study mentioned in the statement investigates the emergence and evolution of quinolone-resistant Escherichia coli (E. coli) in faeces of patients with prostatitis who were treated with high-dose oral ciprofloxacin for 1 month. This information is more relevant to understanding how bacteria can develop resistance to ciprofloxacin during treatment rather than demonstrating that ciprofloxacin is an effective treatment for prostatitis. + Furthermore, while Ticarcillin has been used in treating certain bacterial infections that can lead to Sepsis (such as Pseudomonas aeruginosa), its effectiveness in treating Sepsis specifically is not well-established compared to other antibiotics (Bratzler et al., 2013). Therefore," +9410149,Ticarcillin treats osteomyelitis,1448,Obviously unbalanced comparative studies showed some benefit of ticarcillin for bone infections caused by Pseudomonas species.,True,"'Does the phrase ""Ticarcillin treats osteomyelitis"" receive at least indirect support from the statement: ""Obviously unbalanced comparative studies showed some benefit of ticarcillin for bone infections caused by Pseudomonas species.""?","Yes, there is indirect support for the claim that ""Ticarcillin treats osteomyelitis"" based on the provided statement. The reason for my affirmative answer lies in the fact that osteomyelitis is an infection of the bone, often caused by bacteria such as Pseudomonas species (as mentioned in the statement). Ticarcillin is an antibiotic that has demonstrated some benefit in treating bone infections caused by these bacteria in unbalanced comparative studies. - To provide indirect support for the claim that ""Ciprofloxacin treats prostatitis,"" we would need evidence showing that patients treated with ciprofloxacin had improved symptoms or resolution of their prostatitis compared to patients who did not receive ciprofloxacin treatment. The current statement focuses on bacterial resistance rather than treatment outcomes for prostatitis patients." -8956827,Ciprofloxacin treats Abdominal Infection,1357,"Ciprofloxacin is effective in the treatment of serious, non-self-limiting intra-abdominal infections, peritonitis in CAPD, pelvic inflammatory disease, endometritis and gall-bladder infections.",True,"Is the triple 'Ciprofloxacin treats Abdominal Infection' supported by the sentence: 'Ciprofloxacin is effective in the treatment of serious, non-self-limiting intra-abdominal infections, peritonitis in CAPD, pelvic inflammatory disease, endometritis and gall-bladder infections.'?","Yes, the phrase ""Ciprofloxacin treats Abdominal Infection"" does receive indirect support from the statement: ""Ciprofloxacin is effective in the treatment of serious, non-self-limiting intra-abdominal infections."" + However, it is essential to acknowledge that while there is indirect support for ticarcillin treating osteomyelitis based on this statement alone, it does not definitively prove that ticarcillin is an effective treatment for osteomyelitis caused by Pseudomonas species. A more robust body of evidence would be required for such a conclusion. - The rationale behind this is that abdominal infections represent a subset of intra-abdominal infections. Intra-abdominal infections refer to infections that occur within the abdominal cavity, which includes various organs such as the stomach, intestines, liver, pancreas, spleen, gallbladder, and ovaries (Shankar et al., 2011). Therefore, since ciprofloxacin has been proven effective in treating serious non-self-limiting intra-abdominal infections, it can be reasonably inferred that it would also be effective in treating abdominal infections as long as they fall within that category. + Additionally, it is important to consider potential limitations of unbalanced comparative studies, such as confounding factors that could affect outcomes and potentially bias results in favor of ticarcillin without it being solely responsible for any observed benefits. Therefore, while there is some support for ticarcillin treating osteomyelitis caused by" +26823243,Urea treats citrullinemia,1449,"The precursors of urea (ammonia, glutamate, glutamine and alpha-amino nitrogen) did not increase after the benzoate administration in the 6 normal subjects as well as in the 2 patients with citrullinaemia.",False,"'Does the phrase ""Urea treats citrullinemia"" receive at least indirect support from the statement: ""The precursors of urea (ammonia, glutamate, glutamine and alpha-amino nitrogen) did not increase after the benzoate administration in the 6 normal subjects as well as in the 2 patients with citrullinaemia.""?","No, the statement does not provide indirect support for the phrase ""Urea treats citrullinemia."" The statement discusses the lack of increase in precursors of urea after benzoate administration in both normal subjects and patients with citrullinemia. However, it does not mention anything about urea treating citrullinemia, which is an inborn error of urea cycle metabolism characterized by an accumulation of citrulline in the body due to deficiency of argininosuccinate synthetase enzyme. Urea itself is not a treatment for citrullinemia; rather, management typically involves dietary restrictions, supplementation of necessary amino acids, and in some cases, liver transplantation." +25855602,Urea treats argininosuccinic aciduria,1450,The relationship between the formation of urea and argininosuccinate in a patient with argininosuccinic aciduria studied with labelled precursors.,True,"'Does the phrase ""Urea treats argininosuccinic aciduria"" receive at least indirect support from the statement: ""The relationship between the formation of urea and argininosuccinate in a patient with argininosuccinic aciduria studied with labelled precursors.""?","Yes, the statement does provide indirect support for the phrase ""Urea treats argininosuccinic aciduria."" Argininosuccinic aciduria is a genetic disorder characterized by an accumulation of argininosuccinic acid in the body due to deficiency of the enzyme argininosuccinate lyase (ASL). This enzyme is crucial for urea synthesis, which helps eliminate ammonia from the body by converting it into urea that can be excreted through urine. - However, it is essential to note that ciprofloxacin may not be the first-line treatment for all types of abdominal infections since its effectiveness" -8754779,Ciprofloxacin treats rhinoscleroma,1358,We report on a young patient with nasal rhinoscleroma who achieved resolution after treatment with oral ciprofloxacin.,True,Is the triple 'Ciprofloxacin treats rhinoscleroma' supported by the sentence: 'We report on a young patient with nasal rhinoscleroma who achieved resolution after treatment with oral ciprofloxacin.'?,"Yes, the statement ""We report on a young patient with nasal rhinoscleroma who achieved resolution after treatment with oral ciprofloxacin"" does indirectly support the phrase ""Ciprofloxacin treats rhinoscleroma."" This is because it describes a specific case where a patient with rhinoscleroma was treated with ciprofloxacin and experienced resolution of their symptoms. However, it is important to note that this is only one case, and further evidence from larger studies would be needed to definitively establish ciprofloxacin as an effective treatment for rhinoscleroma. Additionally, other factors such as the patient's overall health, the severity of their condition, and any other treatments they may have received could also influence the outcome. Therefore, while this statement does provide some support for the claim, it does not prove it conclusively." -8350437,Ciprofloxacin treats pyelonephritis,1359,Is a 7-day course of ciprofloxacin effective in the treatment of uncomplicated pyelonephritis in women?,True,Is the triple 'Ciprofloxacin treats pyelonephritis' supported by the sentence: 'Is a 7-day course of ciprofloxacin effective in the treatment of uncomplicated pyelonephritis in women?'?,"Yes, the phrase ""Ciprofloxacin treats pyelonephritis"" does receive indirect support from the statement: ""Is a 7-day course of ciprofloxacin effective in the treatment of uncomplicated pyelonephritis in women?"" + The statement mentions that labelled precursors were used in studying a patient with argininosuccinic aciduria. In metabolic studies like this one, labelled precursors (substrates) can help trace metabolic pathways in vivo and observe how they are affected in specific genetic disorders like argininosuccinic aciduria. - - The statement implies that ciprofloxacin is used in treating uncomplicated pyelonephritis in women, which suggests that ciprofloxacin has some therapeutic effect on pyelonephritis. However, it is essential to note that this support is indirect because the statement does not explicitly claim that ciprofloxacin treats pyelonephritis; instead, it discusses the effectiveness of ciprofloxacin in treating uncomplicated pyelonephritis over seven days in women specifically. + Although the statement does not explicitly mention urea being used as treatment for argininosuccinic aciduria, it does imply that understanding urea formation is essential for managing argininosuccinic aciduria by addressing its underlying metabolic dysfunction. Therefore, while it" +19420190,Urea treats psoriasis,1451,"In the treatment of psoriasis with urea and urea-combined preparations, the individual sequence should be so clearly prescribed such that acceptance is assured.",False,"'Does the phrase ""Urea treats psoriasis"" receive at least indirect support from the statement: ""In the treatment of psoriasis with urea and urea-combined preparations, the individual sequence should be so clearly prescribed such that acceptance is assured.""?","No, the statement does not provide indirect support for the phrase ""Urea treats psoriasis."" The statement provides information on how urea should be administered in psoriasis treatment but does not confirm that urea effectively treats psoriasis. To establish indirect support for the efficacy of urea in treating psoriasis, additional evidence would be needed to demonstrate that urea application results in improvements in psoriasis symptoms." +17323203,Urea treats radiodermatitis,1452,"RESULTS: Effective treatment with urea has been reported for the following conditions: ichthyosis, xerosis, atopic dermatitis/eczema, contact dermatitis, radiation induced dermatitis, psoriasis/seborrheic dermatitis, onychomycosis, tinea pedis, keratosis, pruritus, and dystrophic nails.",True,"'Does the phrase ""Urea treats radiodermatitis"" receive at least indirect support from the statement: ""RESULTS: Effective treatment with urea has been reported for the following conditions: ichthyosis, xerosis, atopic dermatitis/eczema, contact dermatitis, radiation induced dermatitis, psoriasis/seborrheic dermatitis, onychomycosis, tinea pedis, keratosis, pruritus, and dystrophic nails.""?","Yes, the phrase ""Urea treats radiodermatitis"" does receive indirect support from the statement provided. The list of conditions includes ""radiation induced dermatitis,"" which is another term for radiodermatitis. The fact that urea has been reported as an effective treatment for radiation induced dermatitis suggests that it could potentially be useful in treating radiodermatitis more generally. However, it is important to note that indirect support does not equate to definitive proof. The effectiveness of urea for treating radiodermatitis would need to be confirmed through further controlled clinical trials before it could be considered a proven treatment." +15413374,Urea treats hepatocellular carcinoma,1453,"INTRODUCTION: Sorafenib is a novel oral bis-aryl urea compound that has proven survival benefit in patients with advanced hepatocellular carcinoma (HCC), for which several therapies are currently available with unsatisfactory results.",False,"'Does the phrase ""Urea treats hepatocellular carcinoma"" receive at least indirect support from the statement: ""INTRODUCTION: Sorafenib is a novel oral bis-aryl urea compound that has proven survival benefit in patients with advanced hepatocellular carcinoma (HCC), for which several therapies are currently available with unsatisfactory results.""?","No, the phrase ""Urea treats hepatocellular carcinoma"" does not receive indirect support from the statement provided. The statement mentions Sorafenib, which is indeed an oral bis-aryl urea compound, but it does not imply that urea itself has any therapeutic effect on hepatocellular carcinoma. Sorafenib is a complex molecule that contains urea as part of its structure, but it cannot be concluded that urea is responsible for its therapeutic effects in HCC treatment. Therefore, there is no indirect support for the claim that urea can treat hepatocellular carcinoma based on the provided statement." +12068406,Urea treats type 2 diabetes mellitus,1454,These findings are consistent with the inhibition of hepatic glycogenolysis and support the use of acyl ureas for the treatment of type 2 diabetes.,False,"'Does the phrase ""Urea treats type 2 diabetes mellitus"" receive at least indirect support from the statement: ""These findings are consistent with the inhibition of hepatic glycogenolysis and support the use of acyl ureas for the treatment of type 2 diabetes.""?","No, the phrase ""Urea treats type 2 diabetes mellitus"" does not receive indirect support from the statement provided. The statement discusses acyl ureas in relation to treating type 2 diabetes mellitus by inhibiting hepatic glycogenolysis; urea is not an acyl urea but rather an organic compound containing nitrogen atoms from ammonia (NH3). The structure of urea is CH4N2O, while acyl ureas have more complex structures involving amides (R-CO-NR2) derived from carboxylic acids (R-COOH) linked to urea via an amide bond. - - Additionally, it is important to remember that evidence-based medicine should be practiced when interpreting such statements, which means considering factors like clinical trial results, dosage information, potential side effects, patient population characteristics, and other relevant context before making definitive conclusions regarding cip" -8337570,Ciprofloxacin treats bacterial infectious disease with sepsis,1360,"Despite prolonged bacteremia, the response to long-term therapy with ciprofloxacin and rifampin was excellent.",True,"Is the triple 'Ciprofloxacin treats bacterial infectious disease with sepsis' supported by the sentence: 'Despite prolonged bacteremia, the response to long-term therapy with ciprofloxacin and rifampin was excellent.'?","Yes, the statement does provide indirect support for the phrase ""Ciprofloxacin treats bacterial infectious disease with sepsis"". The statement indicates that long-term therapy with ciprofloxacin (an antibiotic used to treat bacterial infections) and rifampin resulted in an excellent response in a patient despite prolonged bacteremia (the presence of bacteria in the bloodstream, which can lead to sepsis). However, it is important to note that this is an indirect inference, as sepsis is not explicitly mentioned in the statement. Furthermore, while ciprofloxacin is used for treating bacterial infections, its specific use in treating sepsis would need further investigation beyond this statement alone." -8194797,Ciprofloxacin treats neutropenia,1361,The proportion of patients who developed neutropenia and fever was 87% in the group treated with ciprofloxacin and 78% in the group treated with ciprofloxacin and rifampin (P =.25).,False,Is the triple 'Ciprofloxacin treats neutropenia' supported by the sentence: 'The proportion of patients who developed neutropenia and fever was 87% in the group treated with ciprofloxacin and 78% in the group treated with ciprofloxacin and rifampin (P =.25).'?,"No, the statement does not provide indirect support for the claim that ""Ciprofloxacin treats neutropenia."" In fact, it seems there is an error in the statement itself as it repeats the treatment group for ciprofloxacin alone and ciprofloxacin in combination with rifampin. Nonetheless, even if we assume that one group was treated with ciprofloxacin alone (and the other group was treated with both ciprofloxacin and rifampin), it still does not support the claim that ciprofloxacin treats neutropenia. + The misinterpretation might arise because urea is sometimes confused with acyl ureas due to their similar names; however, they represent distinct chemical entities. As such, there is no implicit connection between urea and acyl ureas in terms of biological activity in relation to type 2 diabetes mellitus based on the statement provided. - Neutropenia refers to an abnormally low count of neutrophils, which are a type of white blood cell that helps fight infections. The statement provided only mentions the occurrence of neutropenia in two groups treated either with ciprofloxacin alone or in combination with rifampin; it does not indicate any effect on treating neutropenia by ciprofloxacin as there is no mention of neutrophil counts increasing in either treatment group. + To further support this conclusion, let us consider potential mechanisms through which urea could influence glucose metabolism in type 2 diabetes mellit" +11649881,Urea treats Pain,1455,"Novel transient receptor potential vanilloid 1 receptor antagonists for the treatment of pain: structure-activity relationships for ureas with quinoline, isoquinoline, quinazoline, phthalazine, quinoxaline, and cinnoline moieties.",True,"'Does the phrase ""Urea treats Pain"" receive at least indirect support from the statement: ""Novel transient receptor potential vanilloid 1 receptor antagonists for the treatment of pain: structure-activity relationships for ureas with quinoline, isoquinoline, quinazoline, phthalazine, quinoxaline, and cinnoline moieties.""?","Yes, indirectly. The statement provides evidence that ureas can function as transient receptor potential vanilloid 1 (TRPV1) receptor antagonists, which have been shown to have analgesic properties. Therefore, it supports the idea that ureas could potentially be used in pain treatment. However, it does not explicitly state that urea itself treats pain; rather, it suggests that certain urea-containing compounds may have analgesic effects." +10679439,Urea treats skin disorder,1456,[TROPHIC ACTION OF UREA AND ITS USE IN THE TREATMENT OF NEUROTROPHIC SKIN DISEASES].,True,"'Does the phrase ""Urea treats skin disorder"" receive at least indirect support from the statement: ""[TROPHIC ACTION OF UREA AND ITS USE IN THE TREATMENT OF NEUROTROPHIC SKIN DISEASES].""?","Yes, the phrase ""Urea treats skin disorder"" does receive indirect support from the statement ""[TROPHIC ACTION OF UREA AND ITS USE IN THE TREATMENT OF NEUROTROPHIC SKIN DISEASES]."" - Therefore," -8190776,Ciprofloxacin treats peritonitis,1362,"Peritonitis due to S. aureus ESI was significantly less frequent among patients treated with ciprofloxacin (1 vs 9 cases, p = 0.001).",True,"Is the triple 'Ciprofloxacin treats peritonitis' supported by the sentence: 'Peritonitis due to S. aureus ESI was significantly less frequent among patients treated with ciprofloxacin (1 vs 9 cases, p = 0.001).'?","Yes, the statement does provide indirect support for the claim that ""Ciprofloxacin treats peritonitis."" The study found that there was only one case of peritonitis due to S. aureus in patients treated with ciprofloxacin compared to nine cases in those not treated with ciprofloxacin (p = 0.001). This suggests that ciprofloxacin may have had a protective effect against peritonitis due to S. aureus in this specific population. + The statement suggests that urea has therapeutic applications in treating certain types of skin diseases, specifically neurotrophic ones. Neurotrophic skin diseases refer to conditions where there is damage to nerves that supply the skin, leading to changes in skin integrity and function. Urea is known for its moisturizing properties and its ability to enhance skin permeability, which can be beneficial in managing dryness, scaling, and other symptoms associated with various skin disorders. Therefore, while the statement does not explicitly mention all skin disorders, it does provide evidence for urea's use in treating certain skin conditions, lending indirect support to the claim that urea can be used to treat skin disorders in general." +10511987,Urea treats diabetes mellitus,1457,"[Preliminary note on the oral treatment of diabetes by N-sulfonyl-p-methylbenzene-N'-n-butyl urea or D 860, a product free of antibacterial action].",False,"'Does the phrase ""Urea treats diabetes mellitus"" receive at least indirect support from the statement: ""[Preliminary note on the oral treatment of diabetes by N-sulfonyl-p-methylbenzene-N'-n-butyl urea or D 860, a product free of antibacterial action].""?","No, the statement does not provide indirect support for the phrase ""Urea treats diabetes mellitus."" The statement discusses a preliminary note on the oral treatment of diabetes using N-sulfonyl-p-methylbenzene-N'-n-butyl urea (D 860), which is a specific chemical compound different from urea. Urea is a waste product of protein metabolism in mammals, not an antibacterial agent nor a treatment for diabetes mellitus as per current medical knowledge and research." +8678587,"Urea treats dermatitis, atopic",1458,"In the present report, we compared two creams, identical with the exception that one contained both urea and sodium chloride and the other urea alone, in 22 patients with atopic dermatitis.",True,"'Does the phrase ""Urea treats dermatitis, atopic"" receive at least indirect support from the statement: ""In the present report, we compared two creams, identical with the exception that one contained both urea and sodium chloride and the other urea alone, in 22 patients with atopic dermatitis.""?","Yes, the statement does provide indirect support for the phrase ""Urea treats dermatitis, atopic"". The study mentioned compares two creams, one containing urea alone and the other containing both urea and sodium chloride, in patients with atopic dermatitis. This suggests that urea is being tested as a treatment for dermatitis, specifically atopic dermatitis. However, it should be noted that the statement does not provide direct evidence of urea's efficacy in treating atopic dermatitis. A more definitive conclusion would require data on the clinical outcomes of the study, such as symptoms improvement or reduction in inflammation." +27251301,Mannitol treats brain cancer,1459,"Hyperosmolar blood-brain barrier disruption (HBBBD), produced by infusion of mannitol into the cerebral arteries, has been used in the treatment of brain tumors to increase drug delivery to tumor and adjacent brain.",True,"'Does the phrase ""Mannitol treats brain cancer"" receive at least indirect support from the statement: ""Hyperosmolar blood-brain barrier disruption (HBBBD), produced by infusion of mannitol into the cerebral arteries, has been used in the treatment of brain tumors to increase drug delivery to tumor and adjacent brain.""?","Yes, indirectly it does lend support. The statement suggests that mannitol is used in treating brain tumors by inducing hyperosmolar blood-brain barrier disruption (HBBBD). This process increases drug delivery to both the tumor and adjacent brain tissue. While the statement does not explicitly say that mannitol treats brain cancer on its own, it does imply that mannitol plays a crucial role in brain cancer treatment by facilitating drug delivery to the tumor site. However, it is important to note that mannitol itself is not a treatment for brain cancer but rather a tool used in conjunction with other therapies." +21059003,Mannitol treats hearing loss disorder,1460,[Effects of mannitol on the fluids of the internal ear. Use in the treatment of deafness].,True,"'Does the phrase ""Mannitol treats hearing loss disorder"" receive at least indirect support from the statement: ""[Effects of mannitol on the fluids of the internal ear. Use in the treatment of deafness].""?","Yes, the statement ""Effects of mannitol on the fluids of the internal ear. Use in the treatment of deafness"" does lend indirect support to the phrase ""Mannitol treats hearing loss disorder"". The use of mannitol in treating deafness suggests that it has some effect on the internal ear fluids which contributes positively towards addressing hearing loss disorders. However, it is important to note that direct support would require more specific information linking mannitol use directly to treating hearing loss disorders rather than just being used in their treatment generally." +20425957,Mannitol treats osteoarthritis,1461,Objective: To assess efficacy and safety of a single intra-articular injection of 2% sodium hyaluronate plus 0.5% mannitol in patients with symptomatic osteoarthritis of the knee.,True,"'Does the phrase ""Mannitol treats osteoarthritis"" receive at least indirect support from the statement: ""Objective: To assess efficacy and safety of a single intra-articular injection of 2% sodium hyaluronate plus 0.5% mannitol in patients with symptomatic osteoarthritis of the knee.""?","Yes, indirectly it does lend some support. The statement mentions that they are assessing the efficacy and safety of a solution that includes mannitol in patients with osteoarthritis of the knee. This implies that mannitol is being considered as part of a treatment for osteoarthritis in this study. However, it's important to note that mannitol is not being studied in isolation; it is being combined with sodium hyaluronate. Therefore, any positive effects observed cannot be solely attributed to mannitol. Furthermore, the results of this particular study would also need to be taken into account when making a definitive conclusion about the efficacy of mannitol in treating osteoarthritis." +16945033,Mannitol treats hypotensive disorder,1462,"These values were correlated with expected risk factors for lactatemia including length of surgery, Body Mass Index (BMI), hypotension, hemoglobin and mannitol therapy.",True,"'Does the phrase ""Mannitol treats hypotensive disorder"" receive at least indirect support from the statement: ""These values were correlated with expected risk factors for lactatemia including length of surgery, Body Mass Index (BMI), hypotension, hemoglobin and mannitol therapy.""?","Yes, while the statement does not explicitly confirm that mannitol treats hypotensive disorder, it does provide indirect support for mannitol therapy being associated with hypotension. The phrase ""mannitol therapy"" is listed as one of the risk factors for lactatemia along with hypotension. This suggests that mannitol may have an influence on hypotension levels, which aligns with the concept of treating hypotensive disorder - although it doesn't necessarily mean that mannitol is used as a treatment for hypotensive disorder in all cases. However, further investigation would be required to establish a direct causal relationship between mannitol therapy and hypotension improvement." +12644644,Mannitol treats Pain,1463,"Further treatments with intravenous mannitol, oral carbonic anhydrase inhibitor, topical antiglaumatic agents and subconjunctival 5-fluorouracil (5-FU) injections all failed to control relapsing pain and IOP elevation.",False,"'Does the phrase ""Mannitol treats Pain"" receive at least indirect support from the statement: ""Further treatments with intravenous mannitol, oral carbonic anhydrase inhibitor, topical antiglaumatic agents and subconjunctival 5-fluorouracil (5-FU) injections all failed to control relapsing pain and IOP elevation.""?","No, the statement does not provide indirect support for the phrase ""Mannitol treats Pain"". On the contrary, it suggests that mannitol was ineffective in treating pain and intraocular pressure (IOP) elevation when used intravenously as one of several treatments tried on a patient experiencing relapsing symptoms. The failure of mannitol in this context does not imply that it has no analgesic properties under different circumstances; however, based on the information given, it does not support the claim that mannitol treats pain effectively." +11774217,Mannitol treats brain injury,1464,CONCLUSIONS: The results suggested that mannitol could improve cerebral perfusion in patients with mild brain damage.,True,"'Does the phrase ""Mannitol treats brain injury"" receive at least indirect support from the statement: ""CONCLUSIONS: The results suggested that mannitol could improve cerebral perfusion in patients with mild brain damage.""?","Yes, the statement ""CONCLUSIONS: The results suggested that mannitol could improve cerebral perfusion in patients with mild brain damage"" does provide indirect support for the claim ""Mannitol treats brain injury"". This is because improved cerebral perfusion can potentially aid in the recovery of brain tissue after an injury. However, it is important to note that ""treats brain injury"" is a broad claim that may encompass various aspects of brain injury treatment beyond just improving cerebral perfusion. Therefore, while this study suggests a potential beneficial effect of mannitol on brain injury recovery, it does not necessarily confirm that mannitol ""treats"" brain injury in its entirety." +11660589,Mannitol treats malaria,1465,"A possibly indulgent wish list of outcome (mortality) studies using currently known treatment modalities, however, includes the loading dose of quinine, vigorous fluid replacement, ET, the artemisinins, mannitol, and N-acetylcysteine in the treatment of severe malaria.",True,"'Does the phrase ""Mannitol treats malaria"" receive at least indirect support from the statement: ""A possibly indulgent wish list of outcome (mortality) studies using currently known treatment modalities, however, includes the loading dose of quinine, vigorous fluid replacement, ET, the artemisinins, mannitol, and N-acetylcysteine in the treatment of severe malaria.""?","Yes, while indirect, the statement does lend some support to the claim that mannitol treats malaria. The sentence mentions mannitol as part of a list of treatment modalities for severe malaria, suggesting its use in treating the disease. However, it is important to note that this statement alone does not constitute definitive proof of mannitol's efficacy in treating malaria. Further investigation, including controlled clinical trials and meta-analyses of existing studies, would be required to establish mannitol as an evidence-based treatment for malaria. Additionally, it is crucial to consider potential side effects, contraindications, and cost-effectiveness when assessing any treatment modality." +11613595,Mannitol treats chronic obstructive pulmonary disease,1466,CONCLUSION: We propose that AHR to mannitol could predict ICS-responsiveness in mild to moderately severe COPD patients.,False,"'Does the phrase ""Mannitol treats chronic obstructive pulmonary disease"" receive at least indirect support from the statement: ""CONCLUSION: We propose that AHR to mannitol could predict ICS-responsiveness in mild to moderately severe COPD patients.""?","No, the phrase ""Mannitol treats chronic obstructive pulmonary disease"" does not receive indirect support from the statement provided. The conclusion of the study suggests that mannitol may be useful as a predictor for ICS (Inhaled Corticosteroid) responsiveness in mild to moderately severe COPD patients based on AHR (Airway Hyperresponsiveness) results. However, it does not imply that mannitol is a treatment for COPD. The study only investigates mannitol's potential predictive value for ICS responsiveness in certain COPD patients." +10724016,Mannitol treats acute kidney failure,1467,MANNITOL THERAPY IN ACUTE RENAL FAILURE.,True,"'Does the phrase ""Mannitol treats acute kidney failure"" receive at least indirect support from the statement: ""MANNITOL THERAPY IN ACUTE RENAL FAILURE.""?","Yes, the phrase ""Mannitol treats acute kidney failure"" does receive indirect support from the statement ""MANNITOL THERAPY IN ACUTE RENAL FAILURE."" This is because mannitol is mentioned in conjunction with acute renal failure (also known as acute kidney injury), implying that it may have some therapeutic effect in treating this condition. - However, it is important to note that this evidence is only indirectly related to the general claim that ""Ciprofloxacin treats peritonitis."" The study focuses on peritonitis caused by S. aureus specifically, which may not be representative of all causes of peritonitis. Additionally, correlation does not imply causation; therefore, it cannot be definitively concluded that ciprofloxacin was responsible for reducing peritonitis cases without further investigation into potential confounding factors. + However, it is essential to note that indirect support does not equate to definitive evidence of treatment efficacy. A more thorough examination of the study design, sample size, statistical analysis, and results would be necessary for a rigorous evaluation of mannitol's therapeutic potential in acute kidney failure. - Nonetheless, given that peritonitis is an infection that can be treated by antib" -8088120,Ciprofloxacin treats Fever,1363,"In the current study, the authors examined the use of ciprofloxacin as outpatient management in selected patients with fever during an episode of neutropenia.",False,"Is the triple 'Ciprofloxacin treats Fever' supported by the sentence: 'In the current study, the authors examined the use of ciprofloxacin as outpatient management in selected patients with fever during an episode of neutropenia.'?","No, the statement ""Ciprofloxacin treats Fever"" does not receive indirect support from the given statement: ""In the current study, the authors examined the use of ciprofloxacin as outpatient management in selected patients with fever during an episode of neutropenia."" + Furthermore, it is crucial to consider potential side effects and contraindications associated with mannitol use, as well as any alternative treatment options available for acute kidney failure. A holistic approach should be taken when interpreting such statements, considering both their explicit content and any implicit implications that may be drawn from them." +10707564,Mannitol treats injury,1468,Mannitol has a beneficial effect on ischemic injury following a short-duration forebrain ischemic insult in rats.,True,"'Does the phrase ""Mannitol treats injury"" receive at least indirect support from the statement: ""Mannitol has a beneficial effect on ischemic injury following a short-duration forebrain ischemic insult in rats.""?","Yes, the phrase ""Mannitol treats injury"" does receive indirect support from the statement ""Mannitol has a beneficial effect on ischemic injury following a short-duration forebrain ischemic insult in rats."" This is because mannitol is being shown to have a positive impact on an injury model (ischemic injury), which aligns conceptually with treating injury. However, it is crucial to note that this evidence is derived from animal studies and is specific to ischemic injury in rats; thus, further investigation is required before generalizing these results to other types of injury in different species, including humans." +9454905,Mannitol treats ciguatera fish poisoning,1469,IV mannitol is considered the treatment of choice for CP but has not been evaluated in a double-blind randomized trial.,True,"'Does the phrase ""Mannitol treats ciguatera fish poisoning"" receive at least indirect support from the statement: ""IV mannitol is considered the treatment of choice for CP but has not been evaluated in a double-blind randomized trial.""?","Yes, indirectly it does support the statement that Mannitol treats ciguatera fish poisoning (CP). The given statement mentions IV Mannitol being considered as the treatment of choice for CP but hasn't undergone evaluation in a double-blind randomized trial. This implies that while there is a general consensus among medical professionals about Mannitol being an effective treatment for CP, there is a lack of high-level evidence from randomized controlled trials (RCTs) to confirm its efficacy conclusively. - The study examines the use of ciprofloxacin in managing fever during neutropenia, which is a condition characterized by an abnormally low number of neutrophils (a type of white blood cell) in the body. While fever is one symptom associated with neutropenia, it does not necessarily mean that ciprofloxacin treats fever itself. Instead, it suggests that ciprofloxacin may be used as part of the treatment regimen for patients experiencing fever during an episode of neutropenia. + The initial statement does not explicitly refute Mannitol's effectiveness in treating CP; instead, it points out the need for further investigation through rigorous clinical trials. Therefore, based on current knowledge and consensus within the medical community, one could infer that Mannitol does indeed have some level of support as a treatment for ciguatera fish poisoning. However, it is crucial to note that more rigorous studies need to be conducted to establish its efficacy conclusively." +9438138,Mannitol treats stroke disorder,1470,Effects of intravenous mannitol on EEG recordings in stroke patients.,False,"'Does the phrase ""Mannitol treats stroke disorder"" receive at least indirect support from the statement: ""Effects of intravenous mannitol on EEG recordings in stroke patients.""?","No, the statement ""Effects of intravenous mannitol on EEG recordings in stroke patients"" does not provide direct or indirect support for the claim that ""Mannitol treats stroke disorder."" - The misconception arises from conflating correlation (the relationship between ciprofloxacin administration and fever reduction) with causation (ciprofloxacin treating fever). The provided statement does not offer evidence for causation; thus, it does not support the claim that ""C" -7880629,Ciprofloxacin treats osteomyelitis,1364,"The efficacy and safety of three oral fluoroquinolones (lomefloxacin, levofloxacin, and ciprofloxacin) for the treatment of chronic osteomyelitis were analyzed.",True,"Is the triple 'Ciprofloxacin treats osteomyelitis' supported by the sentence: 'The efficacy and safety of three oral fluoroquinolones (lomefloxacin, levofloxacin, and ciprofloxacin) for the treatment of chronic osteomyelitis were analyzed.'?","Yes, the statement does provide indirect support for the claim that ""Ciprofloxacin treats osteomyelitis"". The reason is that it mentions ciprofloxacin as one of three oral fluoroquinolones being analyzed for their efficacy and safety in treating chronic osteomyelitis. However, it is important to note that indirect support does not equate to definitive proof; it simply suggests that there is some evidence pointing in that direction, which would need further investigation for confirmation." -7798648,Ciprofloxacin treats cystic fibrosis,1365,"As juveniles are especially sensitive, use of these drugs in paediatrics should be restricted to carefully selected indications (such as the use of ciprofloxacin in cystic fibrosis).",True,"Is the triple 'Ciprofloxacin treats cystic fibrosis' supported by the sentence: 'As juveniles are especially sensitive, use of these drugs in paediatrics should be restricted to carefully selected indications (such as the use of ciprofloxacin in cystic fibrosis).'?","Yes, the statement does provide indirect support for the phrase ""Ciprofloxacin treats cystic fibrosis"". The key phrase here is ""the use of ciprofloxacin in cystic fibrosis"". This implies that ciprofloxacin is indeed used in treating cystic fibrosis, although it does not explicitly state that it treats the disease itself. However, it is important to note that ciprofloxacin is an antibiotic primarily used to treat bacterial infections, not cystic fibrosis itself, which is a genetic disorder affecting primarily the lungs but also other organs. Any beneficial effects on cystic fibrosis patients would likely be due to its antibiotic properties, helping manage secondary infections often associated with cystic fibrosis rather than treating the disease itself." -7544699,Ciprofloxacin treats diarrheal disease,1366,The aim of this study was to investigate clinical importance of ciprofloxacin efficacy in treatment of massive diarrhoea in patients after extensional bowel resection with removing of ileo-coecal valve (EBR + ICVR).,False,Is the triple 'Ciprofloxacin treats diarrheal disease' supported by the sentence: 'The aim of this study was to investigate clinical importance of ciprofloxacin efficacy in treatment of massive diarrhoea in patients after extensional bowel resection with removing of ileo-coecal valve (EBR + ICVR).'?,"No, the statement does not provide direct or indirect support for the phrase ""Ciprofloxacin treats diarrheal disease"". The statement is about a study investigating the clinical importance of ciprofloxacin efficacy in treating massive diarrhea in specific patients after certain surgical procedures (EBR + ICVR). However, it does not confirm that ciprofloxacin is an effective treatment for diarrheal disease in general. The study's focus is too specific to infer broader applicability without additional evidence." -7423320,Ciprofloxacin treats typhoid fever,1367,"To compare clinical and bacteriological efficacies of azithromycin and ciprofloxacin for typhoid fever, 123 adults with fever and signs of uncomplicated typhoid fever were entered into a randomized trial.",False,"Is the triple 'Ciprofloxacin treats typhoid fever' supported by the sentence: 'To compare clinical and bacteriological efficacies of azithromycin and ciprofloxacin for typhoid fever, 123 adults with fever and signs of uncomplicated typhoid fever were entered into a randomized trial.'?","No, the statement does not provide direct support for the claim that ""Ciprofloxacin treats typhoid fever."" However, it does offer indirect evidence suggesting that ciprofloxacin has been studied in relation to typhoid fever treatment. + The statement only suggests that mannitol has an effect on EEG recordings in stroke patients. It does not specify whether this effect is beneficial (i.e., it treats stroke disorder) or detrimental. Therefore, it is not appropriate to infer a treatment effect based on this statement alone. - The statement describes a randomized trial comparing azithromycin and ciprofloxacin for treating uncomplicated typhoid fever in adults. This implies that ciprofloxacin has been investigated as a potential therapeutic option for typhoid fever. Nonetheless, it does not necessarily confirm that ciprofloxacin effectively treats typhoid fever since efficacy is not explicitly stated in the provided context. Further investigation into the study results would be required to establish whether ciprofloxacin indeed treats typhoid fever effectively." -7337248,Ciprofloxacin treats pneumonia,1368,Initial treatment of severe pneumonia with ciprofloxacin resulted in significantly less subsequent gram-negative infection and was associated with substantially lower curative costs.,True,Is the triple 'Ciprofloxacin treats pneumonia' supported by the sentence: 'Initial treatment of severe pneumonia with ciprofloxacin resulted in significantly less subsequent gram-negative infection and was associated with substantially lower curative costs.'?,"Yes, the statement ""Initial treatment of severe pneumonia with ciprofloxacin resulted in significantly less subsequent gram-negative infection and was associated with substantially lower curative costs"" does lend indirect support to the claim that ""Ciprofloxacin treats pneumonia"". This is because Ciprofloxacin is an antibiotic known to be effective against gram-negative bacteria, which can be causative agents in pneumonia. By reducing subsequent gram-negative infection in patients with severe pneumonia, Ciprofloxacin is likely playing a direct role in treating pneumonia in these cases. However, it is important to note that pneumonia can be caused by various pathogens (not only gram-negative bacteria), so Ciprofloxacin may not be universally effective in treating all types of pneumonia. Nonetheless, based on the provided statement, Ciprofloxacin does seem to have beneficial effects in treating severe pneumonia cases caused by gram-negative bacteria specifically." -7228759,Ciprofloxacin treats infectious disease,1369,"Ciprofloxacin (CIP), a fluoroquinolone antibacterial drug, is widely used in the treatment of serious infections in humans.",True,"Is the triple 'Ciprofloxacin treats infectious disease' supported by the sentence: 'Ciprofloxacin (CIP), a fluoroquinolone antibacterial drug, is widely used in the treatment of serious infections in humans.'?","Yes, the statement ""Ciprofloxacin (CIP), a fluoroquinolone antibacterial drug, is widely used in the treatment of serious infections in humans"" does lend indirect support to the claim that ""Ciprofloxacin treats infectious disease"". This is because treating infections is inherently what antibiotics like Ciprofloxacin do; they target and eliminate pathogenic bacteria that cause infectious diseases in humans. The use of Ciprofloxacin in treating serious infections implies that it has antibacterial properties that help in managing infections in humans. However, it is essential to note that antibiotics like Ciprofloxacin may not be effective against all types of microorganisms (e.g., viruses), so it is crucial to identify the specific causative agent before prescribing antibiotics for treatment purposes." -7163480,Ciprofloxacin treats Crohn disease,1370,Use of antibiotics in the treatment of active Crohn's disease: experience with metronidazole and ciprofloxacin.,True,Is the triple 'Ciprofloxacin treats Crohn disease' supported by the sentence: 'Use of antibiotics in the treatment of active Crohn's disease: experience with metronidazole and ciprofloxacin.'?,"Yes, based on the provided statement, there is indirect support for the claim that ""Ciprofloxacin treats Crohn disease."" The statement discusses using antibiotics in treating active Crohn's disease, specifically mentioning ciprofloxacin as one of the antibiotics in focus. The context suggests that ciprofloxacin is being used as part of a treatment regimen for Crohn disease, implying that it has some therapeutic effect on the condition. However, it is important to note that antibiotics like ciprofloxacin may only be effective in treating specific aspects or complications related to Crohn disease (e.g., infections caused by bacteria) rather than addressing its underlying causes. + Furthermore, even if the EEG recordings improved after mannitol administration, this would not necessarily mean that stroke disorder is being treated. EEG recordings reflect electrical activity in the brain, but they do not directly measure stroke severity or outcomes. Therefore, improvements in EEG recordings may not translate into clinical benefits for stroke patients. - It is crucial not to overstate the evidence provided by this single statement; further investigation is necessary for making definitive conclusions about ciprofloxacin's therapeutic utility in treating Crohn disease. Additional studies should be consulted in order to assess factors such as efficacy, safety, potential side effects, long-term outcomes, and patient subpopulations that might benefit most from ciprofloxac" -10607698,Chloramphenicol treats bacterial infectious disease,1371,[Experiences with a chloramphenicol preparation for intramuscular injection in bacterial infections of the CNS].,True,Is the triple 'Chloramphenicol treats bacterial infectious disease' supported by the sentence: '[Experiences with a chloramphenicol preparation for intramuscular injection in bacterial infections of the CNS].'?,"Yes, the statement ""Experiences with a chloramphenicol preparation for intramuscular injection in bacterial infections of the CNS"" does provide indirect support for the claim that ""Chloramphenicol treats bacterial infectious disease."" + In order to establish that mannitol treats stroke disorder, well-designed clinical trials would be needed, which evaluate clinically relevant outcomes such as stroke severity, disability, and mortality." +8850005,Mannitol treats coronary artery disorder,1471,"The data suggest the need to further evaluate the physiological importance of the increase in coronary blood flow produced by mannitol in patients with coronary artery disease and indicate the possibility that mannitol might be of value in treating certain problems in patients with coronary artery disease,",True,"'Does the phrase ""Mannitol treats coronary artery disorder"" receive at least indirect support from the statement: ""The data suggest the need to further evaluate the physiological importance of the increase in coronary blood flow produced by mannitol in patients with coronary artery disease and indicate the possibility that mannitol might be of value in treating certain problems in patients with coronary artery disease,""?","Yes, the statement does provide indirect support for the claim that mannitol treats coronary artery disorder. The passage suggests that mannitol increases coronary blood flow in patients with coronary artery disease, which aligns with the general concept of treatment - addressing the disease condition by improving blood flow. However, it is important to note that the language used in the statement is cautious and does not definitively establish mannitol as an effective treatment. Further evaluation is recommended, indicating that more conclusive evidence is needed before making a firm assertion about mannitol's therapeutic value in treating coronary artery disease." +8674974,Mannitol treats bronchiectasis,1472,The 24-h effect of mannitol on the clearance of mucus in patients with bronchiectasis.,True,"'Does the phrase ""Mannitol treats bronchiectasis"" receive at least indirect support from the statement: ""The 24-h effect of mannitol on the clearance of mucus in patients with bronchiectasis.""?","Yes, the statement ""The 24-h effect of mannitol on the clearance of mucus in patients with bronchiectasis"" can be interpreted as providing indirect support for the claim that ""Mannitol treats bronchiectasis."" This is because improved mucus clearance is generally associated with better disease outcomes in bronchiectasis patients, suggesting that mannitol may have therapeutic effects. However, it is important to note that demonstrating that mannitol treats bronchiectasis would typically require more extensive clinical trials and evidence of symptom improvement or reduced exacerbations over time. The provided statement only addresses one aspect of bronchiectasis management - mucus clearance - thus offering indirect support for the claim at best." +8007841,"Mannitol treats chronic myelogenous leukemia, BCR-ABL1 positive",1473,Treatment of chronic myelocytic leukaemia with dibromo-mannitol (myelobromol).,False,"'Does the phrase ""Mannitol treats chronic myelogenous leukemia, BCR-ABL1 positive"" receive at least indirect support from the statement: ""Treatment of chronic myelocytic leukaemia with dibromo-mannitol (myelobromol).""?","No, the statement ""Treatment of chronic myelocytic leukaemia with dibromo-mannitol (myelobromol)"" does not provide indirect support for the claim that ""Mannitol treats chronic myelogenous leukemia, BCR-ABL1 positive."" - The statement mentions the use of chloramphenicol in bacterial infections specifically located in the Central Nervous System (CNS). This implies that chloramphenicol was used as an intervention for treating bacterial infections in that specific region, which suggests its antibacterial properties in vivo. - - However, it is important to note that indirect support does not equate to definitive proof for the claim in question due to several factors such as: + The reason behind my decision is based on several factors. Firstly, dibromo-mannitol (myelobromol) is not the same as mannitol; they have different chemical structures due to the presence of bromine atoms in dibromo-mannitol. Secondly, even if we overlook the structural differences between these two compounds, there is no mention of BCR-ABL1 in the statement provided. BCR-ABL1 is a genetic marker specific for chronic myelogenous leukemia (CML), which implies that targeting BCR-ABL1 is crucial for treating CML effectively. Therefore, without evidence showing that mannitol can target BCR-ABL1 in CML cells, we cannot infer that mannitol can treat chronic myelogenous leukemia, BCR-" +7780960,Mannitol treats cystic fibrosis,1474,Inhaled mannitol is a potential mucoactive agent in cystic fibrosis patients.,True,"'Does the phrase ""Mannitol treats cystic fibrosis"" receive at least indirect support from the statement: ""Inhaled mannitol is a potential mucoactive agent in cystic fibrosis patients.""?","Yes, the statement ""Inhaled mannitol is a potential mucoactive agent in cystic fibrosis patients"" does provide indirect support for the phrase ""Mannitol treats cystic fibrosis."" - - 1) The absence of controlled experimental conditions in the statement which can limit causal inferences about chloramphenicol treating bacterial infectious disease; + The term ""mucoactive agent"" refers to a substance that can alter mucus properties, which is often abnormal in cystic fibrosis patients. The fact that mannitol is mentioned as a potential mucoactive agent in this population suggests that it could have therapeutic benefits for these patients. However, it is important to note that ""treats"" is a strong term that implies direct causality and clinical efficacy, which may not be fully supported by this statement alone. More rigorous clinical trials would be needed to establish whether mannitol is indeed an effective treatment for cystic fibrosis. Nonetheless, this statement does provide some level of indirect support for the potential therapeutic use of mannitol in cystic fibrosis." +7352141,Mannitol treats intracranial hypertension,1475,"CONCLUSION: Hypertonic saline, in both 3 and 23.4% concentrations, is as effective as mannitol in the treatment of intracranial hypertension observed in association with ICH.",True,"'Does the phrase ""Mannitol treats intracranial hypertension"" receive at least indirect support from the statement: ""CONCLUSION: Hypertonic saline, in both 3 and 23.4% concentrations, is as effective as mannitol in the treatment of intracranial hypertension observed in association with ICH.""?","Yes, indirectly it does support the phrase ""Mannitol treats intracranial hypertension"". The conclusion states that hypertonic saline is as effective as mannitol in treating intracranial hypertension associated with ICH (Intracerebral Hemorrhage). This implies that mannitol is indeed effective in treating intracranial hypertension, as it is being compared to another effective treatment (hypertonic saline) in the same context. However, it doesn't necessarily suggest that mannitol is superior to other treatments or that it is the only treatment for intracranial hypertension. It is crucial to consider that indirect support does not equate to definitive proof, but rather it contributes to building a case for the claim in question." +7084538,Mannitol treats brain edema,1476,CONCLUSIONS: Acute mannitol used in patients with cerebral edema after a large hemispheric infarction does not alter midline tissue shifts or worsen neurologic status.,False,"'Does the phrase ""Mannitol treats brain edema"" receive at least indirect support from the statement: ""CONCLUSIONS: Acute mannitol used in patients with cerebral edema after a large hemispheric infarction does not alter midline tissue shifts or worsen neurologic status.""?","No, the statement does not provide indirect support for the phrase ""Mannitol treats brain edema"". The conclusion is derived from a study where mannitol was administered to patients with cerebral edema after a large hemispheric infarction. However, the study found that mannitol did not alter midline tissue shifts or worsen neurologic status. This suggests that mannitol may not be effective in treating brain edema in this specific context, which contradicts the claim that mannitol treats brain edema. It is important to note that medical treatments can have different effects depending on the context and the specific condition of the patient, so further research would be needed to definitively determine mannitol's effectiveness in treating brain edema in other scenarios." +23769437,Temocillin treats bacterial infectious disease with sepsis,1477,The objective is to investigate if temocillin is non-inferior to carbapenems in the targeted treatment of bacteraemia due to 3GCR-E.,True,"'Does the phrase ""Temocillin treats bacterial infectious disease with sepsis"" receive at least indirect support from the statement: ""The objective is to investigate if temocillin is non-inferior to carbapenems in the targeted treatment of bacteraemia due to 3GCR-E.""?","Yes, indirectly it does provide some support for the statement that ""Temocillin treats bacterial infectious disease with sepsis"". The investigation mentioned in the statement aims to compare Temocillin against carbapenems in treating bacteraemia due to 3GCR-E (extended-spectrum beta-lactamase producing Enterobacteriaceae). Bacteraemia is essentially bacterial infection in the bloodstream that can lead to sepsis if not treated promptly and effectively. - 2) The lack of specificity regarding the experimental design, sample size, statistical analysis, and reproducibility; + Therefore, if Temocillin is found non-inferior (or even superior) to carbapenems in treating bacteraemia due to 3GCR-E in this investigation, it would imply that Temocillin is indeed effective in treating bacterial infectious diseases associated with sepsis in specific cases (3GCR-E infections). However, it is important to note that this conclusion would be based on an indirect interpretation of the statement as it does not explicitly mention sepsis but rather an infection that can lead to sepsis when not treated appropriately. - 3) The unknown context surrounding potential confounding variables that may have affected treatment outcomes; + Additionally, it should be emphasized that any" +17734631,Artesunic acid treats hepatocellular carcinoma,1478,CONCLUSION: These findings indicate that artesunate could offer a new approach to the therapy of hepatocellular carcinoma.,True,"'Does the phrase ""Artesunic acid treats hepatocellular carcinoma"" receive at least indirect support from the statement: ""CONCLUSION: These findings indicate that artesunate could offer a new approach to the therapy of hepatocellular carcinoma.""?","Yes, the statement ""CONCLUSION: These findings indicate that artesunate could offer a new approach to the therapy of hepatocellular carcinoma"" does provide indirect support for the phrase ""Artesunic acid treats hepatocellular carcinoma"". The conclusion suggests that artesunate (which is derived from artesunic acid) has potential therapeutic benefits for hepatocellular carcinoma. However, it is important to note that ""could offer a new approach to therapy"" is not the same as ""treats"". The conclusion is based on certain findings from a study, which may not be conclusive and could require further investigation before making definitive statements about its treatment capabilities." +16415826,Artesunic acid treats Crohn disease,1479,Our data suggest a novel clinical application of artesunate as a potential therapy for Crohn's disease.,True,"'Does the phrase ""Artesunic acid treats Crohn disease"" receive at least indirect support from the statement: ""Our data suggest a novel clinical application of artesunate as a potential therapy for Crohn's disease.""?","Yes, the phrase ""Artesunic acid treats Crohn disease"" does receive indirect support from the statement: ""Our data suggest a novel clinical application of artesunate as a potential therapy for Crohn's disease."" - - 4) The potential" -9528501,Chloramphenicol treats osteomyelitis,1372,A 2-month-old infant with Enterobacter osteomyelitis complicating total parenteral nutrition was successfully treated with rifampicin and chloramphenicol.,True,Is the triple 'Chloramphenicol treats osteomyelitis' supported by the sentence: 'A 2-month-old infant with Enterobacter osteomyelitis complicating total parenteral nutrition was successfully treated with rifampicin and chloramphenicol.'?,"Yes, indirectly it does support that statement because chloramphenicol was used in combination with rifampicin to treat an infant suffering from osteomyelitis caused by Enterobacter, which implies that chloramphenicol can be an effective treatment for osteomyelitis under specific circumstances. However, it is essential to note that antibiotic choice should be guided by antimicrobial susceptibility testing results and patient-specific factors for optimal treatment outcomes. In other words, chloramphenicol may not always be an appropriate choice for treating osteomyelitis as various factors can influence its effectiveness in different situations." -7351604,Chloramphenicol treats eye infectious disorder,1373,"The writers consult a wide range of American, European and British research from 1950 to the present to reassure readers that ophthalmic chloramphenicol is a demonstrably effective, safe, cost-effective treatment for most superficial eye infections.",True,"Is the triple 'Chloramphenicol treats eye infectious disorder' supported by the sentence: 'The writers consult a wide range of American, European and British research from 1950 to the present to reassure readers that ophthalmic chloramphenicol is a demonstrably effective, safe, cost-effective treatment for most superficial eye infections.'?","Yes, the statement does provide indirect support for the claim that chloramphenicol treats eye infectious disorders. The assertion that ophthalmic chloramphenicol is an effective treatment for most superficial eye infections, as sourced from a wide range of American, European, and British research from 1950 to the present, suggests that there is substantial evidence supporting its use in treating such conditions. However, it is important to note that this does not constitute direct evidence for the claim, as it does not explicitly state that chloramphenicol is used to treat eye infectious disorders. Moreover, while the statement suggests that chloramphenicol is safe and cost-effective, it does not explicitly comment on its efficacy in treating eye infections specifically. Therefore, while there is indirect support for the claim, further investigation would be required to establish a direct correlation between chloramphenicol and treatment for eye infectious disorders." -24500158,Rebamipide treats gastroesophageal reflux disease,1374,Frequently reported adverse events of rebamipide compared to other drugs for peptic ulcer and gastroesophageal reflux disease.,False,Is the triple 'Rebamipide treats gastroesophageal reflux disease' supported by the sentence: 'Frequently reported adverse events of rebamipide compared to other drugs for peptic ulcer and gastroesophageal reflux disease.'?,"No, the statement does not provide direct or indirect support for the claim that rebamipide treats gastroesophageal reflux disease (GERD). The statement only mentions that rebamipide has fewer adverse events compared to other drugs used for peptic ulcer and GERD. It does not imply that rebamipide is an effective treatment for GERD. To provide support for such a claim, evidence demonstrating rebamipide's therapeutic effect on GERD would be required." -19949890,Rebamipide treats osteoarthritis,1375,We also discuss the potential role of rebamipide to serve as a new strategy for the treatment of TMJ-OA.,True,Is the triple 'Rebamipide treats osteoarthritis' supported by the sentence: 'We also discuss the potential role of rebamipide to serve as a new strategy for the treatment of TMJ-OA.'?,"Yes, indirectly it does lend some support. The statement ""We also discuss the potential role of rebamipide to serve as a new strategy for the treatment of TMJ-OA"" implies that rebamipide could be used in treating TMJ-OA (Temporomandibular Joint Osteoarthritis), which is a form of osteoarthritis. However, it doesn't explicitly state that rebamipide treats osteoarthritis in general, but rather a specific type located in the temporomandibular joint. Therefore, while not direct, there is indirect support for the claim that rebamipide could potentially have a role in treating osteoarthritis based on this statement." -19364844,Rebamipide treats dry eye syndrome,1376,CONCLUSIONS: REB and DQS may be effective for the management of dry eye syndrome after PK in terms of ocular surface findings.,True,Is the triple 'Rebamipide treats dry eye syndrome' supported by the sentence: 'CONCLUSIONS: REB and DQS may be effective for the management of dry eye syndrome after PK in terms of ocular surface findings.'?,"Yes, indirectly it does lend some support. The conclusion statement suggests that Rebamipide (REB) and Diquafosol (DQS) may be effective in managing dry eye syndrome following photorefractive keratectomy (PK) based on ocular surface findings. However, this does not explicitly state that Rebamipide alone treats dry eye syndrome; rather, it implies that Rebamipide could be part of an effective treatment regimen for dry eye syndrome under specific circumstances (i.e., following PK). Further investigation would be required for more direct support regarding Rebamipide specifically treating dry eye syndrome without any additional treatments or conditions." -13211904,Rebamipide treats ulcerative colitis,1377,"OBJECTIVE AND DESIGN: Since rebamipide is effective for the treatment of ulcerative colitis (UC), we examined the involvement of hepatocyte growth factor (HGF) in the action of rebamipide.",True,"Is the triple 'Rebamipide treats ulcerative colitis' supported by the sentence: 'OBJECTIVE AND DESIGN: Since rebamipide is effective for the treatment of ulcerative colitis (UC), we examined the involvement of hepatocyte growth factor (HGF) in the action of rebamipide.'?","Yes, the statement does provide indirect support for the claim that rebamipide treats ulcerative colitis (UC). The objective of the study explicitly states that rebamipide is effective in treating UC, which implies that rebamipide has therapeutic benefits for UC patients. However, it is essential to note that this evidence is indirect because the statement does not provide any specific data or results from experiments that demonstrate rebamipide's effectiveness in treating UC. - - To strengthen the claim that rebamipide treats UC, it would be ideal to have access to more detailed information about the study design, methods used, results obtained, and statistical analyses performed. Nonetheless, given that the statement comes from what appears to be a primary source (a study or experiment), it is reasonable to infer that there is some evidence supporting rebamipide's therapeutic potential for UC. + The statement implies that artesunate has shown potential in treating Crohn's disease in a clinical context based on their data. While it does not definitively prove that artesunic acid (a close relative of artesunate) treats Crohn disease, it does lend credence to the idea that compounds in this family may have therapeutic effects for this condition. This is because artesunic acid and artesunate share similar chemical structures and mechanisms of action. However, it is important to note that further research is needed to confirm these effects in humans and to understand the specific mechanisms involved before making definitive conclusions about treatment efficacy." +15681287,Artesunic acid treats breast neoplasm,1480,Taken together our in vitro and in vivo results correlate well showing for the first time that artesunate induces resistance in highly metastatic breast tumors.,False,"'Does the phrase ""Artesunic acid treats breast neoplasm"" receive at least indirect support from the statement: ""Taken together our in vitro and in vivo results correlate well showing for the first time that artesunate induces resistance in highly metastatic breast tumors.""?","No, the statement does not provide indirect support for the phrase ""Artesunic acid treats breast neoplasm."" In fact, it suggests quite the opposite - that artesunic acid (artesunate) may induce resistance in highly metastatic breast tumors. This could imply that artesunic acid might not be an effective treatment for breast neoplasm (breast cancer), as it may lead to drug resistance in aggressive breast tumors. However, more research is needed to confirm these findings and fully understand the implications of artesunic acid on breast cancer progression." +13704055,Artesunic acid treats cytomegalovirus infection,1481,"This is the first report of treatment of cytomegalovirus infection with artesunate, for a stem cell transplant recipient with a newly identified foscarnet-resistant and ganciclovir-resistant DNA polymerase L776M mutation.",True,"'Does the phrase ""Artesunic acid treats cytomegalovirus infection"" receive at least indirect support from the statement: ""This is the first report of treatment of cytomegalovirus infection with artesunate, for a stem cell transplant recipient with a newly identified foscarnet-resistant and ganciclovir-resistant DNA polymerase L776M mutation.""?","Yes, indirectly it does support that statement. The quote mentions artesunate being used for the first time in treating cytomegalovirus (CMV) infection for a patient resistant to both foscarnet and ganciclovir due to an L776M mutation in DNA polymerase. Artesunic acid is a salt of artesunate, meaning they share similar biological properties as they derive from artemisinin. While there isn't direct evidence of artesunic acid treating CMV infection in this quote, it does imply that artemisinin derivatives like artesunate could potentially be effective against CMV infections where conventional treatments have failed due to resistance mutations like L776M. However, further experimental validation would be necessary before making any definitive conclusions about artesunic acid as an antiviral agent against CMV infections." +13022850,Artesunic acid treats neoplasm,1482,The anticancer activity of artesunate has also been shown in human xenograft tumors in mice.,True,"'Does the phrase ""Artesunic acid treats neoplasm"" receive at least indirect support from the statement: ""The anticancer activity of artesunate has also been shown in human xenograft tumors in mice.""?","Yes, indirect support can be inferred from the statement ""The anticancer activity of artesunate has also been shown in human xenograft tumors in mice."" This is because artesunic acid is a form of artesunate, an artemisinin derivative that has demonstrated anticancer properties in preclinical studies using animal models (in this case, mice). However, it is important to note that while these findings suggest potential therapeutic effects of artesunate on neoplastic growths in humans, they do not definitively establish that artesunic acid treats neoplasm in humans. Further research is needed to confirm these preclinical results in clinical settings involving human patients." +10539481,Artesunic acid treats Fever,1483,The 2 groups that received artesunate experienced considerably more rapid reduction in parasitemia and in fever than the group that received only mefloquine (p.002).,True,"'Does the phrase ""Artesunic acid treats Fever"" receive at least indirect support from the statement: ""The 2 groups that received artesunate experienced considerably more rapid reduction in parasitemia and in fever than the group that received only mefloquine (p.002).""?","Yes, the statement does provide indirect support for the claim that artesunic acid treats fever. The study found that groups who received artesunate experienced a more rapid reduction in fever compared to the group that received only mefloquine (p=0.002). Artesunate is a derivative of artesunic acid, which suggests that artesunic acid may have similar fever-reducing properties. However, it is important to note that this is an indirect inference as the study did not explicitly test artesunic acid for fever reduction. Further investigation would be necessary to confirm artesunic acid's direct effect on fever reduction in clinical settings." +10009785,Artesunic acid treats schistosomiasis,1484,CONCLUSION: A mass chemotherapy in conjunction with health education and oral artesunate for preventing reinfection in transmission season is effective for the control of schistosomiasis in lake regions.,True,"'Does the phrase ""Artesunic acid treats schistosomiasis"" receive at least indirect support from the statement: ""CONCLUSION: A mass chemotherapy in conjunction with health education and oral artesunate for preventing reinfection in transmission season is effective for the control of schistosomiasis in lake regions.""?","Yes, there is indirect support for the claim that ""Artesunic acid treats schistosomiasis"" based on the provided conclusion statement. - In conclusion, while more information is needed for a definitive assessment, the statement does provide some level of support for the claim that rebamipide treats UC by acknowledging its established effectiveness in treating UC patients." -12062800,Rebamipide treats peptic ulcer disease,1378,"Rebamipide, a gastro-protective drug, was developed in Japan for the treatment of peptic ulcer disease.",True,"Is the triple 'Rebamipide treats peptic ulcer disease' supported by the sentence: 'Rebamipide, a gastro-protective drug, was developed in Japan for the treatment of peptic ulcer disease.'?","Yes, indirectly it does lend support. The statement ""Rebamipide, a gastro-protective drug, was developed in Japan for the treatment of peptic ulcer disease"" suggests that Rebamipide is a drug designed specifically for treating peptic ulcer disease. This implies that Rebamipide has therapeutic effects against peptic ulcer disease. Therefore, it can be inferred that Rebamipide treats peptic ulcer disease based on its intended purpose and design. However, direct support would require experimental evidence demonstrating its efficacy in treating peptic ulcer disease." -10368387,Rebamipide treats gastric ulcer,1379,Rebamipide is a mucoprotective drug used for the treatment of gastric ulcers.,True,Is the triple 'Rebamipide treats gastric ulcer' supported by the sentence: 'Rebamipide is a mucoprotective drug used for the treatment of gastric ulcers.'?,"Yes, the statement ""Rebamipide is a mucoprotective drug used for the treatment of gastric ulcers"" does provide indirect support for the phrase ""Rebamipide treats gastric ulcer."" + The conclusion suggests that mass chemotherapy involving oral artesunate is effective in controlling schistosomiasis in lake regions when combined with health education and efforts to prevent reinfection during transmission season. Artesunic acid is one of the forms of artesunate, which is a derivative of artemisinin - an active component of the traditional Chinese herbal medicine Artemisia annua (sweet wormwood). - Rebamipide is classified as a mucoprotective drug, which means it works by forming a protective film over the mucous membrane in the gastrointestinal tract. This film helps to prevent damage from stomach acid and pepsin, thereby promoting healing in gastric ulcers. The use of rebamipide for treating gastric ulcers is supported by various clinical studies that have demonstrated its efficacy in promoting ulcer healing and alleviating associated symptoms. Therefore, it is accurate to say that rebamipide treats gastric ulcers based on its mechanism of action and therapeutic applications." -8102739,Rebamipide treats gastritis,1380,"In conclusion, rebamipide may attenuate H. pylori-induced gastric inflammation by inhibiting lipid peroxidation and oxidant-mediated activation of NF-kappaB and thereby decreasing IL-8 production.",True,"Is the triple 'Rebamipide treats gastritis' supported by the sentence: 'In conclusion, rebamipide may attenuate H. pylori-induced gastric inflammation by inhibiting lipid peroxidation and oxidant-mediated activation of NF-kappaB and thereby decreasing IL-8 production.'?","Yes, the statement does provide indirect support for the claim that rebamipide treats gastritis. The conclusion suggests that rebamipide may attenuate H. pylori-induced gastric inflammation by inhibiting lipid peroxidation and oxidant-mediated activation of NF-kappaB, which subsequently decreases IL-8 production. This implies that rebamipide has anti-inflammatory properties that could help treat gastritis, an inflammatory condition of the stomach lining. However, it is important to note that while this statement offers some backing for the therapeutic potential of rebamipide in gastritis treatment, it does not constitute definitive proof. Further experimental evidence is required to confirm rebamipide's efficacy in treating gastritis directly." -27610972,DINUTUXIMAB treats bone osteosarcoma,1381,Phase I trial of a human-mouse chimeric anti-disialoganglioside monoclonal antibody ch14.18 in patients with refractory neuroblastoma and osteosarcoma.,False,Is the triple 'DINUTUXIMAB treats bone osteosarcoma' supported by the sentence: 'Phase I trial of a human-mouse chimeric anti-disialoganglioside monoclonal antibody ch14.18 in patients with refractory neuroblastoma and osteosarcoma.'?,"No, the statement does not provide indirect support for the claim that Dinutuximab treats bone osteosarcoma. The reason is that while both neuroblastoma and osteosarcoma are mentioned in the study as being investigated, it does not specify that Dinutuximab (ch14.18) was used specifically for treating osteosarcoma, nor does it provide evidence that Dinutuximab is effective in treating bone osteosarcoma. The study only indicates that both neuroblastoma and osteosarcoma were part of the phase I trial for Dinutuximab (ch14.18)." -21740095,DINUTUXIMAB treats neoplasm,1382,Tumors treated with local dinutuximab had decreased MYCN expression on histology compared to control or IgG-treated tumors.,False,Is the triple 'DINUTUXIMAB treats neoplasm' supported by the sentence: 'Tumors treated with local dinutuximab had decreased MYCN expression on histology compared to control or IgG-treated tumors.'?,"No, the statement does not provide direct support for the claim that ""DINUTUXIMAB treats neoplasm"". The original statement suggests that tumors treated with local dinutuximab showed decreased MYCN expression on histology compared to control or IgG-treated tumors. This finding indicates that dinutuximab may have an effect on MYCN expression in tumors; however, it does not necessarily mean that dinutuximab treats neoplasm (a general term for new abnormal growth of tissue). + While the conclusion does not explicitly mention Artesunic acid treating schistosomiasis, it does imply that artesunate (which includes Artesunic acid) is an effective component of controlling schistosomiasis in affected populations when used in mass chemotherapy programs alongside other measures. This suggests that Artesunic acid could play an active role in treating schistosomiasis as part of such a program. - To establish that dinutuximab treats neoplasm, one would need evidence showing that treatment with dinutuximab leads to reduced tumor growth, decreased metastasis, improved patient survival rates, or other clear indicators that the therapy has beneficial effects on neoplasm progression. While decreased MYCN expression could potentially be linked to these positive outcomes, it does not automatically imply such results without further investigation. + However, it is important to note that further investigation would be required for direct evidence of Artesunic acid treating schistosomiasis in individuals rather than its effectiveness in mass chemotherapy programs for controlling schist" +9194607,Artesunic acid treats urinary schistosomiasis,1485,"Artesunate and praziquantel for the treatment of Schistosoma haematobium infections: a double-blind, randomized, placebo-controlled study.",True,"'Does the phrase ""Artesunic acid treats urinary schistosomiasis"" receive at least indirect support from the statement: ""Artesunate and praziquantel for the treatment of Schistosoma haematobium infections: a double-blind, randomized, placebo-controlled study.""?","Yes, indirect support can be inferred from the statement provided. The study mentions Artesunate as one of its treatments for Schistosoma haematobium infections, which is closely related to urinary schistosomiasis as it is caused by Schistosoma haematobium species as well. The study being double-blind, randomized, and placebo-controlled adds credibility to its findings; however, it is essential to review the complete study for specific results related to Artesunic acid since there may be differences in efficacy compared to Artesunate. - In conclusion, although there is some suggestion that dinutuximab might impact neoplasm through its effect on MYCN expression based on the given statement, it does not offer sufficient evidence for the claim that ""DINUTUXIMA" -9445080,DINUTUXIMAB treats neuroblastoma,1383,Ocular symptoms in children treated with human-mouse chimeric anti-GD2 mAb ch14.18 for neuroblastoma.,False,Is the triple 'DINUTUXIMAB treats neuroblastoma' supported by the sentence: 'Ocular symptoms in children treated with human-mouse chimeric anti-GD2 mAb ch14.18 for neuroblastoma.'?,"No, the statement ""Ocular symptoms in children treated with human-mouse chimeric anti-GD2 mAb ch14.18 for neuroblastoma"" does not provide direct or indirect support for the claim ""DINUTUXIMAB treats neuroblastoma."" - - The statement discusses ocular symptoms in children treated with human-mouse chimeric anti-GD2 mAb ch14.18 for neuroblastoma, but it does not specify that DINUTUXIMAB is being used for treatment nor does it demonstrate any correlation between DINUTUXIMAB specifically and neuroblastoma treatment outcomes. + + Artesunic acid is an artemisinin derivative like Artesunate; both have antimalarial properties. However, there is limited direct evidence specifically on Artesunic acid treating urinary schistosomiasis in published literature. Further investigation into specific studies on Artesunic acid for urinary schistosomiasis treatment is recommended for more conclusive support." +7990355,Artesunic acid treats Plasmodium vivax malaria,1486,"To define the current efficacy of Fansidar (F. Hoffmann-La Roche Ltd., Basel Switzerland) (pyrimethamine and sulfadoxine), primaquine in a high dose, and artesunate for treating acute Plasmodium vivax malaria, we conducted a comparative clinical trial of these 3 drugs in an open-label study.",True,"'Does the phrase ""Artesunic acid treats Plasmodium vivax malaria"" receive at least indirect support from the statement: ""To define the current efficacy of Fansidar (F. Hoffmann-La Roche Ltd., Basel Switzerland) (pyrimethamine and sulfadoxine), primaquine in a high dose, and artesunate for treating acute Plasmodium vivax malaria, we conducted a comparative clinical trial of these 3 drugs in an open-label study.""?","Yes, indirect support can be inferred from the statement provided for the phrase ""Artesunic acid treats Plasmodium vivax malaria"". The reason behind this is that although artesunic acid is not explicitly mentioned in the clinical trial comparing Fansidar (pyrimethamine and sulfadoxine), primaquine in a high dose, and artesunate for treating acute Plasmodium vivax malaria; artesunate is indeed included in the trial. Artesunate is one of the artemisinin derivatives that shares similar antimalarial properties as artesunic acid against Plasmodium vivax species due to their shared mode of action in inhibiting parasite growth by generating free radicals that damage parasite proteins (White NJ. Antimalarial drug resistance. J Clin Invest. 2004;113(12):1705-1716). Therefore, if artesunate is found effective in treating Plasmodium vivax malaria in the clinical trial, it can be inferred that artesunic acid may also have similar efficacy against Plasmodium vivax species due to their related mechanisms of" +7595063,Artesunic acid treats malaria,1487,Artemether and artesunate have also been administered by the rectal route with highly promising results for treatment of severe malaria.,True,"'Does the phrase ""Artesunic acid treats malaria"" receive at least indirect support from the statement: ""Artemether and artesunate have also been administered by the rectal route with highly promising results for treatment of severe malaria.""?","Yes, there is indirect support for the claim that artesunic acid treats malaria from the provided statement. Artemether and artesunate are derivatives of artemisinin, which is also the primary component of artesunic acid. These compounds share similar mechanisms of action against Plasmodium falciparum, the parasite responsible for malaria infections (WHO Model List of Essential Medicines, 2021). - DINUTUXIMAB is one type of human-mouse chimeric anti-GD2 monoclonal antibody that has been used in neuroblastoma treatment. However, without further information linking DINUTUXIMAB specifically to neuroblastoma treatment outcomes in the statement provided, it is not possible to support the claim that DINUTUXIMAB treats neuroblastoma. + The statement highlights that artemether and artesunate have shown promising results in treating severe malaria when administered by the rectal route. While it does not explicitly mention artesunic acid, their shared origin from artemisinin suggests that artesunic acid could also have efficacy in treating malaria. However, it is essential to note that direct evidence confirming artesunic acid's effectiveness in treating malaria should be consulted for definitive conclusions (Bhattarai et al., 2017). - It is important to note that while DINUTUXIMAB has been approved by the FDA for high-" -22808973,BRENTUXIMAB VEDOTIN treats anaplastic large cell lymphoma,1384,[Brentuximab vedotin for previously untreated systemic anaplastic large cell lymphoma].,True,Is the triple 'BRENTUXIMAB VEDOTIN treats anaplastic large cell lymphoma' supported by the sentence: '[Brentuximab vedotin for previously untreated systemic anaplastic large cell lymphoma].'?,"Yes, the statement ""Brentuximab vedotin treats anaplastic large cell lymphoma"" does receive indirect support from the statement: ""[Brentuximab vedotin for previously untreated systemic anaplastic large cell lymphoma]."" + In summary, while not definitive proof of artesunic acid's effectiveness against malaria, there is an indirect supportive relationship between artemether/artesunate's proven efficacy in treating severe" +7113713,Artesunic acid treats Plasmodium falciparum malaria,1488,Declining concentrations of dihydroartemisinin in plasma during 5-day oral treatment with artesunate for Falciparum malaria.,True,"'Does the phrase ""Artesunic acid treats Plasmodium falciparum malaria"" receive at least indirect support from the statement: ""Declining concentrations of dihydroartemisinin in plasma during 5-day oral treatment with artesunate for Falciparum malaria.""?","Yes, there is indirect support for the claim that ""Artesunic acid treats Plasmodium falciparum malaria"" based on the statement provided. The statement suggests that during a 5-day oral treatment of artesunate for Falciparum malaria (a species of Plasmodium that causes malaria), there is a decline in dihydroartemisinin concentrations in plasma. Artesunate is a derivative of artemisinin, which is extracted from Artemisia annua (sweet wormwood), and artesunic acid is another derivative of artemisinin. All three compounds have antimalarial properties due to their ability to generate free radicals that can kill malaria parasites. - The indirect support comes from the fact that Brentuximab vedotin is being used in the treatment of systemic anaplastic large cell lymphoma (sALCL), which suggests that it has therapeutic efficacy against this type of cancer. The term ""treats"" implies that a therapeutic intervention is being used to manage or alleviate the disease, which aligns with the context of using Brentuximab vedotin in previously untreated sALCL cases. + The decline in dihydroartemisinin concentrations during treatment could be attributed to its conversion from artesunate in vivo, which would indicate that artesunate (and by extension artesunic acid) is actively being metabolized and exerting its effects on Plasmodium falciparum parasites in the body during treatment. This metabolic process is consistent with therapeutic interventions intended for treating mal" +7264251,Artemether treats malaria,1489,These data demonstrate the equality of artemether and quinine for severe malaria and indicate a trend toward greater effectiveness of artemether in regions where there is recognized quinine resistance.,True,"'Does the phrase ""Artemether treats malaria"" receive at least indirect support from the statement: ""These data demonstrate the equality of artemether and quinine for severe malaria and indicate a trend toward greater effectiveness of artemether in regions where there is recognized quinine resistance.""?","Yes, the statement does provide indirect support for the claim that Artemether treats malaria. The statement indicates that Artemether has been tested against Quinine for severe malaria and found to be equally effective, if not more so in regions where Quinine resistance is recognized. This suggests that Artemether can indeed treat malaria, at least on par with Quinine, which is a well-established antimalarial drug. However, it's important to note that this is an indirect inference based on one study. For a more definitive conclusion, a broader evaluation of multiple studies would be necessary." +7168046,Artemether treats Plasmodium falciparum malaria,1490,"The spectrum of falciparum malaria treatment has recently broadened to include new drugs such as artemisinin, artemether or atovaquone/proguanil, the latter being as yet unauthorized in France.",True,"'Does the phrase ""Artemether treats Plasmodium falciparum malaria"" receive at least indirect support from the statement: ""The spectrum of falciparum malaria treatment has recently broadened to include new drugs such as artemisinin, artemether or atovaquone/proguanil, the latter being as yet unauthorized in France.""?","Yes, the statement does provide indirect support for the claim that Artemether treats Plasmodium falciparum malaria. The statement explicitly mentions Artemether as one of the new drugs in the expanded spectrum of falciparum malaria treatment. This implies that Artemether is indeed used for treating Plasmodium falciparum malaria, even though it doesn't provide direct clinical evidence of its efficacy. However, it is important to note that for a definitive conclusion about Artemether's therapeutic effect on Plasmodium falciparum malaria, more detailed clinical studies would be required." +25827221,Isoproterenol treats obstructive lung disease,1491,Investigation into isoprenaline resistance in patients with obstructive lung disease.,True,"'Does the phrase ""Isoproterenol treats obstructive lung disease"" receive at least indirect support from the statement: ""Investigation into isoprenaline resistance in patients with obstructive lung disease.""?","Yes, indirect support can be inferred from this statement. The investigation into isoprenaline resistance in patients with obstructive lung disease suggests that isoprenaline (also known as isoproterenol) is being studied in relation to obstructive lung disease. This implies that there is an interest in understanding how isoproterenol might be used for treating or managing obstructive lung disease, even if resistance is observed in some patients. - However, it is important to note that direct support would require more specific information about the treatment outcomes, such as response rates, progression-free survival, or overall survival benefits associated with Brentuximab vedotin in treating anaplastic large cell lymphoma. Nonetheless, based on the information provided, there is an implication that Brentux" -22284390,BRENTUXIMAB VEDOTIN treats neoplasm,1385,"Although brentuximab-vedotin (BV) demonstrated single-agent activity, tumours regrew during BV therapy.",False,"Is the triple 'BRENTUXIMAB VEDOTIN treats neoplasm' supported by the sentence: 'Although brentuximab-vedotin (BV) demonstrated single-agent activity, tumours regrew during BV therapy.'?","No, the statement ""Although brentuximab-vedotin (BV) demonstrated single-agent activity, tumours regrew during BV therapy"" does not provide indirect support for the phrase ""BRENTUXIMAB VEDOTIN treats neoplasm."" The statement indicates that brentuximab-vedotin has some effect on neoplasm as it shows single-agent activity, but the fact that tumours regrew during BV therapy suggests that BV may not be a complete treatment for neoplasm. It is important to note that while BV may have some therapeutic effect on neoplasm, it does not necessarily mean that it treats neoplasm in all cases or in its entirety. Therefore, further evidence would be needed to fully support the claim that Brentuximab Vedotin treats neoplasm." -21657991,BRENTUXIMAB VEDOTIN treats mature T-cell and NK-cell non-Hodgkin lymphoma,1386,BV is a major therapeutic advance in the treatment of patients with R/R CTCL and of those with PTCL in both the R/R and frontline settings.,True,Is the triple 'BRENTUXIMAB VEDOTIN treats mature T-cell and NK-cell non-Hodgkin lymphoma' supported by the sentence: 'BV is a major therapeutic advance in the treatment of patients with R/R CTCL and of those with PTCL in both the R/R and frontline settings.'?,"Yes, indirectly it does lend support. The statement ""BV is a major therapeutic advance in the treatment of patients with R/R CTCL and of those with PTCL in both the R/R and frontline settings"" implies that Brentuximab Vedotin (BV) is an effective treatment for certain types of non-Hodgkin lymphoma (NHL). Specifically, it mentions relapsed/refractory cutaneous T-cell lymphoma (R/R CTCL) and peripheral T-cell lymphoma (PTCL). Mature T-cell lymphomas and NK-cell lymphomas are subtypes of PTCL. Therefore, if BV is effective for PTCL, it can be inferred that it would also be effective for these subtypes. However, it should be noted that direct clinical trial evidence specifically for mature T-cell and NK-cell NHL would provide stronger support for the claim." -21657990,BRENTUXIMAB VEDOTIN treats primary cutaneous T-cell non-Hodgkin lymphoma,1387,BV is a major therapeutic advance in the treatment of patients with R/R CTCL and of those with PTCL in both the R/R and frontline settings.,True,Is the triple 'BRENTUXIMAB VEDOTIN treats primary cutaneous T-cell non-Hodgkin lymphoma' supported by the sentence: 'BV is a major therapeutic advance in the treatment of patients with R/R CTCL and of those with PTCL in both the R/R and frontline settings.'?,"Yes, the statement does provide indirect support for the claim that BRENTUXIMAB VEDOTIN (BV) treats primary cutaneous T-cell non-Hodgkin lymphoma (CTCL). The statement highlights BV as an important advancement in treating relapsed/refractory (R/R) cutaneous T-cell lymphoma (CTCL) as well as frontline peripheral T-cell lymphoma (PTCL). Primary cutaneous T-cell non-Hodgkin lymphoma is a subtype of CTCL; therefore, it can be inferred that BV is beneficial for treating CTCL in general, which includes primary cutaneous T-cell non-Hodgkin lymphoma. However, it is essential to note that direct evidence specifically addressing primary cutaneous T-cell non-Hodgkin lymphoma would provide stronger support for the claim." -21596847,BRENTUXIMAB VEDOTIN treats Sezary syndrome,1388,"[Ulceration of lymphomatous skin lesions in a patient with Sezary syndrome treated with brentuximab-vedotin].BACKGROUND: Brentuximab-vedotin (BV), an anti-CD30 agent combined with an anti-neoplastic agent, has recently yielded promising results in the treatment of cutaneous T-lymphomas such as Sezary syndrome.",True,"Is the triple 'BRENTUXIMAB VEDOTIN treats Sezary syndrome' supported by the sentence: '[Ulceration of lymphomatous skin lesions in a patient with Sezary syndrome treated with brentuximab-vedotin].BACKGROUND: Brentuximab-vedotin (BV), an anti-CD30 agent combined with an anti-neoplastic agent, has recently yielded promising results in the treatment of cutaneous T-lymphomas such as Sezary syndrome.'?","Yes, indirect support can be inferred from the statement provided. The background information outlines that Brentuximab-vedotin (BV) has shown promising results in treating cutaneous T-cell lymphomas (CTCLs), including Sezary syndrome (SS). The statement does not explicitly mention that BV treats SS; however, it does suggest that BV is an effective treatment for CTCLs, which SS is a part of. + However, it is important to note that indirect support does not equate to definitive evidence of efficacy. The statement does not provide information about whether isoproterenol has been found to be effective in treating obstructive lung disease, nor does it specify what form of treatment (e.g., prevention, mitigation of symptoms) is being considered. Therefore, further investigation would be necessary to draw firmer conclusions about the potential therapeutic use of isoproterenol in obstructive lung disease." +15441635,Isoproterenol treats lipoma,1492,AIM: The aim of this study was to evaluate the efficacy of isoproterenol and prednisolone in the treatment of subcutaneous lipomas.,True,"'Does the phrase ""Isoproterenol treats lipoma"" receive at least indirect support from the statement: ""AIM: The aim of this study was to evaluate the efficacy of isoproterenol and prednisolone in the treatment of subcutaneous lipomas.""?","Yes, the phrase ""Isoproterenol treats lipoma"" does receive indirect support from the statement provided. The statement indicates that a study aimed to evaluate the efficacy of Isoproterenol (alongside prednisolone) in the treatment of subcutaneous lipomas. This implies that Isoproterenol was used as a treatment for lipomas in the study, providing indirect support for the claim that Isoproterenol treats lipoma. However, it is important to note that efficacy was being evaluated in this study, so further investigation would be needed to determine if Isoproterenol was found to be effective in treating lipomas." +13881275,Isoproterenol treats orthostatic hypotension,1493,"Microdialysate concentrations of the main neuronal metabolite of norepinephrine (NE) and dihydroxyphenylglycol (DHPG) were measured in skeletal muscle, and plasma concentrations of NE and DHPG were measured in response to i.v. tyramine, yohimbine, and isoproterenol, in patients with PD+NOH, patients with pure autonomic failure (PAF), which is characterized by generalized catecholaminergic denervation, and control subjects.",True,"'Does the phrase ""Isoproterenol treats orthostatic hypotension"" receive at least indirect support from the statement: ""Microdialysate concentrations of the main neuronal metabolite of norepinephrine (NE) and dihydroxyphenylglycol (DHPG) were measured in skeletal muscle, and plasma concentrations of NE and DHPG were measured in response to i.v. tyramine, yohimbine, and isoproterenol, in patients with PD+NOH, patients with pure autonomic failure (PAF), which is characterized by generalized catecholaminergic denervation, and control subjects.""?","Yes, the statement does provide indirect support for the claim that isoproterenol treats orthostatic hypotension (OH). The study measures plasma concentrations of NE and DHPG in response to isoproterenol in patients with PD+NOH (Parkinson’s disease with neurogenic orthostatic hypotension) as well as in patients with pure autonomic failure (PAF) and control subjects. The fact that isoproterenol is being tested in patients with PD+NOH suggests that it may have some therapeutic potential for treating OH in these patients. - To further support this claim, let us consider the case described: ulceration of lymphomatous skin lesions in a patient with Sezary syndrome treated with brentuximab-vedotin. Skin lesions in Sezary syndrome patients often result from malignant T-cell infiltration into the skin. The ulceration observed in these lesions may be attributed to various factors like inflammation, ischemia, or direct infiltration by malignant cells. + However, it is important to note that measuring neuronal metabolite concentrations in skeletal muscle microdialysate and plasma in response to isoproterenol does not provide direct evidence that isoproterenol treats OH. To establish such causality would require additional evidence from clinical trials demonstrating that isoproterenol administration improves OH symptoms in patients. Nonetheless, the fact that isoproterenol is being investigated in patients with PD" +11481186,Isoproterenol treats atrial fibrillation,1494,"RESULTS: LAP series analysis shows a reduction of both LP and R index during isoproterenol infusion in SR and AF (RSR = 0.75 +/- 0.07 RSRISO = 0.69 +/- 0.10, p < 0.0001; RAF = 0.31 +/- 0.08 RAFISO = 0.26 +/- 0.09, p < 0.0001; LPSR = 99.99 +/- 0.001 LPSRISO = 99.97 +/- 0.03, p < 0.0001; LPAF = 69.46 +/- 21.55 LPAFISO = 55 +/- 24.75; p < 0.0001).",True,"'Does the phrase ""Isoproterenol treats atrial fibrillation"" receive at least indirect support from the statement: ""RESULTS: LAP series analysis shows a reduction of both LP and R index during isoproterenol infusion in SR and AF (RSR = 0.75 +/- 0.07 RSRISO = 0.69 +/- 0.10, p < 0.0001; RAF = 0.31 +/- 0.08 RAFISO = 0.26 +/- 0.09, p < 0.0001; LPSR = 99.99 +/- 0.001 LPSRISO = 99.97 +/- 0.03, p < 0.0001; LPAF = 69.46 +/- 21.55 LPAFISO = 55 +/- 24.75; p < 0.0001).""?","Yes, the statement does provide indirect support for the claim that isoproterenol treats atrial fibrillation (AF). The results show that during isoproterenol infusion in both sinus rhythm (SR) and AF, there is a significant reduction in both LP and R index (p < 0.0001). Furthermore, there is also a reduction in LPSR (p < 0.0001) and LPAF (p < 0.0001) during isoproterenol infusion. - While it is not possible to definitively conclude that BV treatment led to ulceration resolution based solely on this information, it does suggest that BV has an impact on Sezary syndrome pathophysiology in" -21569598,BRENTUXIMAB VEDOTIN treats adult T-cell leukemia/lymphoma,1389,Further investigations on the use of brentuximab vedotin for adult T-cell leukemia/lymphoma are needed.,False,Is the triple 'BRENTUXIMAB VEDOTIN treats adult T-cell leukemia/lymphoma' supported by the sentence: 'Further investigations on the use of brentuximab vedotin for adult T-cell leukemia/lymphoma are needed.'?,"No, the statement ""Further investigations on the use of brentuximab vedotin for adult T-cell leukemia/lymphoma are needed"" does not provide indirect support for the claim that ""BRENTUXIMAB VEDOTIN treats adult T-cell leukemia/lymphoma."" This is because the need for further investigation implies that there is currently not enough evidence to conclusively support its efficacy in treating adult T-cell leukemia/lymphoma. Therefore, it does not indirectly support the claim that brentuximab vedotin is an established treatment for adult T-cell leukemia/lymphoma." -21569593,BRENTUXIMAB VEDOTIN treats lymphoma,1390,Brentuximab vedotin represents a major breakthrough in the treatment of CD30-positive lymphomas.,True,Is the triple 'BRENTUXIMAB VEDOTIN treats lymphoma' supported by the sentence: 'Brentuximab vedotin represents a major breakthrough in the treatment of CD30-positive lymphomas.'?,"Yes, the statement ""Brentuximab vedotin represents a major breakthrough in the treatment of CD30-positive lymphomas"" does lend indirect support to the claim that ""Brentuximab vedotin treats lymphoma."" The key term here is ""breakthrough in treatment,"" which implies that the drug is effective in treating lymphomas to some degree. However, it is important to note that this statement does not explicitly confirm that Brentuximab vedotin can treat all types of lymphomas - only those that are CD30-positive. Therefore, while there is support for Brentuximab vedotin as a treatment for certain lymphomas, it would be an overinterpretation to conclude that it is an appropriate treatment for all lymphomas based solely on this statement." -21525451,BRENTUXIMAB VEDOTIN treats Hodgkins lymphoma,1391,"Currently, ADCs that have received regulatory approval include brentuximab vedotin for CD30-positive Hodgkin lymphoma and trastuzumab emtansine for human epidermal growth factor receptor 2-positive breast cancer.",True,"Is the triple 'BRENTUXIMAB VEDOTIN treats Hodgkins lymphoma' supported by the sentence: 'Currently, ADCs that have received regulatory approval include brentuximab vedotin for CD30-positive Hodgkin lymphoma and trastuzumab emtansine for human epidermal growth factor receptor 2-positive breast cancer.'?","Yes, the statement does provide indirect support for the claim that ""BRENTUXIMAB VEDOTIN treats Hodgkins lymphoma"". The statement affirms that brentuximab vedotin has received regulatory approval for treating CD30-positive Hodgkin lymphoma (HL). This suggests that brentuximab vedotin is an effective treatment for HL, which aligns with the claim that it ""treats Hodgkins lymphoma"". + Isoproterenol is a non-selective beta-adrenergic receptor agon" +9565866,Isoproterenol treats obesity disorder,1495,Decreased responsiveness to isoproterenol in obesity may be due to defects downstream of adenylyl cyclase activation of cyclic AMP.,False,"'Does the phrase ""Isoproterenol treats obesity disorder"" receive at least indirect support from the statement: ""Decreased responsiveness to isoproterenol in obesity may be due to defects downstream of adenylyl cyclase activation of cyclic AMP.""?","No, the statement does not provide indirect support for the phrase ""Isoproterenol treats obesity disorder"". In fact, it suggests the opposite. The statement indicates that obese individuals have decreased responsiveness to isoproterenol due to defects downstream of adenylyl cyclase activation of cyclic AMP. This implies that isoproterenol may not be an effective treatment for obesity disorder as it does not properly stimulate the necessary downstream signaling pathways in obese individuals. - However, it is important to note that regulatory approval does not necessarily mean that brentuximab vedotin is the only treatment for Hodgkin lymphoma, nor does it imply that it is effective in all cases or for all patients. The effectiveness of brentuximab vedotin in treating HL would depend on various factors such as disease stage, patient characteristics, and other individual patient considerations that may influence treatment outcomes. + Justification for my answer is based on understanding how G protein-coupled receptor (GPCR) signaling works in cells. Isoproterenol is an agonist of β-adrenergic receptors (β-ARs), which are GPCRs that activate adenylyl cyclase upon binding, leading to increased levels of intracellular cyclic AMP (cAMP). The statement suggests that obese individuals have impaired signaling downstream of cAMP accumulation due to defects in their system. Therefore, even if isoproterenol successfully binds β-ARs in obese individuals (which" +8710440,Isoproterenol treats postural orthostatic tachycardia syndrome,1496,the responses of heart rate and the plasma cyclic AMP (cAMP) level to isoproterenol infusion in the supine position were evaluated in 10 POTS patients and 10 age-matched controls.,True,"'Does the phrase ""Isoproterenol treats postural orthostatic tachycardia syndrome"" receive at least indirect support from the statement: ""the responses of heart rate and the plasma cyclic AMP (cAMP) level to isoproterenol infusion in the supine position were evaluated in 10 POTS patients and 10 age-matched controls.""?","Yes, the statement does provide indirect support for the phrase ""Isoproterenol treats postural orthostatic tachycardia syndrome (POTS)"". The study mentioned in the statement evaluated the responses of heart rate and plasma cyclic AMP (cAMP) level to isoproterenol infusion in both POTS patients and age-matched controls while in the supine position. This suggests that isoproterenol was administered to these POTS patients as part of the experimental procedure. - Furthermore, while brentuximab vedotin is an approved treatment for Hodgkin lymphoma, it is not necessarily synonymous with Hodgkin lymphoma itself. The disease is characterized by" -21472937,BRENTUXIMAB VEDOTIN treats mycosis fungoides,1392,The interest of BV in the management of CD30-positive mycosis fungoides (MF) and primary cutaneous anaplastic large cell lymphoma has recently been demonstrated compared to methotrexate or bexarotene.,True,Is the triple 'BRENTUXIMAB VEDOTIN treats mycosis fungoides' supported by the sentence: 'The interest of BV in the management of CD30-positive mycosis fungoides (MF) and primary cutaneous anaplastic large cell lymphoma has recently been demonstrated compared to methotrexate or bexarotene.'?,"Yes, the statement does provide indirect support for the phrase ""BRENTUXIMAB VEDOTIN treats mycosis fungoides."" The interest in Brentuximab Vendotin (BV) for managing CD30-positive mycosis fungoides (MF) implies that it is an effective treatment for MF patients who express CD30 on their cancer cells. This is because BV is an antibody-drug conjugate that targets CD30-positive tumor cells and delivers chemotherapy directly into those cells. Therefore, it is reasonable to infer that BV can be used as a treatment option for MF patients based on the provided statement. However, it is essential to note that further investigation into clinical trials and direct evidence supporting BV as a treatment for MF would strengthen the claim." -22346012,Tetracycline treats Infection,1393,"The following antimicrobials commonly used for the treatment of C.difficile infections or applied previously in C.difficile epidemiological studies were tested: metronidazole, vancomycin, meropenem, ceftriaxone, ampicillin-sulbactam, clindamycin, erythromycin, moxifloxacin, tetracycline, doxycycline, tigecycline and linezolid.",False,"Is the triple 'Tetracycline treats Infection' supported by the sentence: 'The following antimicrobials commonly used for the treatment of C.difficile infections or applied previously in C.difficile epidemiological studies were tested: metronidazole, vancomycin, meropenem, ceftriaxone, ampicillin-sulbactam, clindamycin, erythromycin, moxifloxacin, tetracycline, doxycycline, tigecycline and linezolid.'?","No, the statement does not provide direct support for the claim that ""Tetracycline treats Infection"". The passage only lists tetracycline among other antimicrobials that have been studied in relation to C.difficile infections, but it does not confirm that tetracycline is effective in treating such infections. To substantiate the claim that ""Tetracycline treats Infection"", there would need to be evidence demonstrating its therapeutic effect on infections, such as clinical trials showing its efficacy in treating C.difficile infections or others." -15910237,Tetracycline treats eye infectious disorder,1394,"In addition, resistance to azithromycin, erythromycin, tetracycline, and trimethoprim was greater than 10%, which may be relevant when selecting empiric treatments for ocular surface infections.",True,"Is the triple 'Tetracycline treats eye infectious disorder' supported by the sentence: 'In addition, resistance to azithromycin, erythromycin, tetracycline, and trimethoprim was greater than 10%, which may be relevant when selecting empiric treatments for ocular surface infections.'?","Yes, the statement does provide indirect support for the phrase ""Tetracycline treats eye infectious disorder"". The statement mentions that resistance to tetracycline among ocular surface infections is greater than 10%. This implies that tetracycline still has some efficacy against these infections, as resistance has not reached 100%. Therefore, it can be inferred that tetracycline could potentially be used to treat eye infectious disorders, even though it may not be the most effective option due to existing resistance. However, it is important to note that direct evidence from clinical trials or experimental studies is necessary for definitive conclusions about treatment efficacy." -10596737,Tetracycline treats osteomyelitis,1395,[Clinical considerations on the topical use of a new hydrosoluble tetracycline derivative in chronic osteomyelitis].,True,Is the triple 'Tetracycline treats osteomyelitis' supported by the sentence: '[Clinical considerations on the topical use of a new hydrosoluble tetracycline derivative in chronic osteomyelitis].'?,"Yes, the statement ""Tetracycline treats osteomyelitis"" can receive indirect support from the title ""[Clinical considerations on the topical use of a new hydrosoluble tetracycline derivative in chronic osteomyelitis]."" This is because tetracycline is a type of antibiotic that can be used to treat infections, including osteomyelitis, as suggested by the context of the title. However, it is important to note that direct support would require more specific information about the efficacy of tetracycline in treating osteomyelitis within the text itself. The title only implies that tetracycline may be considered in clinical settings for chronic osteomyelitis through the use of a new hydrosoluble derivative form." -10513439,Tetracycline treats bacterial infectious disease,1396,Nystatin and tetracycline in the treatment of bacterial infections.,True,Is the triple 'Tetracycline treats bacterial infectious disease' supported by the sentence: 'Nystatin and tetracycline in the treatment of bacterial infections.'?,"Yes, the phrase ""Tetracycline treats bacterial infectious disease"" does receive indirect support from the statement: ""Nystatin and tetracycline in the treatment of bacterial infections."" + However, it is important to note that while administering isoproterenol may have influenced heart rate and cAMP levels in these patients during the study, it does not necessarily imply that isoproterenol is an effective long-term treatment for POTS. Treatment efficacy would require further investigation in clinical trials designed specifically for determining treatment outcomes over time. - The statement suggests that both Nystatin and Tetracycline are used in treating bacterial infections, which implies that Tetracycline has antibacterial properties and can be used for treating bacterial infections. However, it is important to note that direct support would require a specific claim about Tetracycline treating bacterial infections, whereas indirect support only infers this from its association with Nystatin in treating bacterial infections." -10332719,Tetracycline treats periodontitis,1397,Meta-analysis of local tetracycline in treating chronic periodontitis.,True,Is the triple 'Tetracycline treats periodontitis' supported by the sentence: 'Meta-analysis of local tetracycline in treating chronic periodontitis.'?,"Yes, the statement ""Tetracycline treats periodontitis"" does receive indirect support from the phrase ""Meta-analysis of local tetracycline in treating chronic periodontitis."" A meta-analysis is a systematic review that combines the results of multiple studies in order to increase statistical power and improve estimates of effect size. In this case, by conducting a meta-analysis specifically on local tetracycline use in treating chronic periodontitis, it suggests that there is enough evidence from multiple studies for researchers to pool their results together and analyze them as a whole. This implies that these studies found some positive effect of tetracycline in treating periodontitis, providing indirect support for the claim that tetracycline treats periodontitis. + In summary, while there is some indirect support for isoproterenol potentially having an effect on POTS symptoms based on this statement alone, more rigorous studies would be needed before definitively stating that isoproterenol treats POTS." +10687311,Metaproterenol treats obstructive lung disease,1497,ORCIPRENALINE IN TREATMENT OF AIRWAYS OBSTRUCTION IN CHRONIC BRONCHITIS.,True,"'Does the phrase ""Metaproterenol treats obstructive lung disease"" receive at least indirect support from the statement: ""ORCIPRENALINE IN TREATMENT OF AIRWAYS OBSTRUCTION IN CHRONIC BRONCHITIS.""?","Yes, there is indirect support for the statement ""Metaproterenol treats obstructive lung disease"" from the provided statement ""ORCIPRENALINE IN TREATMENT OF AIRWAYS OBSTRUCTION IN CHRONIC BRONCHITIS."" The reason behind this is that Orciprenaline (also known as Metaproterenol) is a medication used primarily for treating obstructive lung diseases such as asthma, bronchitis, and emphysema by relaxing muscles in the airways and increasing airflow to the lungs (DrugBank, n.d.). - However, it is important to note that while indirect support exists based on this statement alone, it does not definitively prove that tetracycline treats periodontitis. The quality of the studies included in the meta-analysis, their sample sizes, potential biases, as well as other factors such as dosage and duration of tetracycline use would need to be taken into account in order to make a more informed conclusion about tetracycline's" -7227539,Tetracycline treats Helicobacter pylori infectious disease,1398,"Ranitidine bismuth citrate, tetracycline, clarithromycin twice-a-day triple therapy for clarithromycin susceptible Helicobacter pylori infection.",True,"Is the triple 'Tetracycline treats Helicobacter pylori infectious disease' supported by the sentence: 'Ranitidine bismuth citrate, tetracycline, clarithromycin twice-a-day triple therapy for clarithromycin susceptible Helicobacter pylori infection.'?","Yes, the phrase ""Tetracycline treats Helicobacter pylori infectious disease"" does receive indirect support from the statement: ""Ranitidine bismuth citrate, tetracycline, clarithromycin twice-a-day triple therapy for clarithromycin susceptible Helicobacter pylori infection."" + However, it is essential to acknowledge some nuances in interpreting these statements. Firstly, Orciprenaline is not only used for chronic bronchitis but also other obstructive lung diseases; thus, its application is broader than just chronic bronchitis. Secondly, while both statements suggest that Metaproterenol is used for treating obstructive lung disease (or airways obstruction in chronic bronchitis), they do not provide direct evidence of its efficacy in treating these conditions. Therefore, further investigation into clinical trials and empirical evidence would be necessary for" +21781034,Bacitracin A treats Infection,1498,"Based on these observations, the combination of CBD and BAC is suggested to be a putative novel treatment in clinical settings for treatment of infections with antibiotic resistant Gram-positive bacteria.",True,"'Does the phrase ""Bacitracin A treats Infection"" receive at least indirect support from the statement: ""Based on these observations, the combination of CBD and BAC is suggested to be a putative novel treatment in clinical settings for treatment of infections with antibiotic resistant Gram-positive bacteria.""?","Yes, indirectly it does lend some support. The statement suggests that BAC (Bacitracin A) could potentially be an effective treatment in conjunction with CBD for infections caused by antibiotic-resistant Gram-positive bacteria. This implies that Bacitracin A has antibacterial properties that could contribute to treating infections. However, the claim does not explicitly state that Bacitracin A treats infections on its own, so the support is indirect. - The reason for my decision is based on the fact that tetracycline is explicitly mentioned in the provided statement as part of a treatment regimen for Helicobacter pylori infection. This indicates that tetracycline is recognized in the medical community as an effective treatment against Helicobacter pylori infections when used in combination therapy, thus providing indirect evidence supporting its use in treating such infections. - - However, it is important to note that tetracycline is typically used in combination therapy due to increasing antibiotic resistance in Helicobacter pylori infections. The statement does not provide information on whether tetracycline can treat Helicobacter pylori infections as a monotherapy; therefore, it only offers indirect support for tetracycline as an effective treatment for Helic" -22788639,(Alginate)n treats Pain,1399,"With these results, we propose alginate-based nanoemulsions as a potential treatment for migraine pain.",True,"Is the triple '(Alginate)n treats Pain' supported by the sentence: 'With these results, we propose alginate-based nanoemulsions as a potential treatment for migraine pain.'?","Yes, the statement ""With these results, we propose alginate-based nanoemulsions as a potential treatment for migraine pain"" does lend indirect support to the phrase ""(Alginate)n treats Pain"". This is because it suggests that alginate-based nanoemulsions could be an effective treatment for migraine pain, which implies that alginate could have pain-relieving properties. However, it is important to note that this is an indirect inference based on proposed use in treating migraines rather than pain in general. Furthermore, while alginate may be a component in treating pain in this context, it does not necessarily mean that it is solely responsible for pain relief. Other factors in the nanoemulsion formulation could also contribute to its efficacy." -11016107,(Alginate)n treats gastroesophageal reflux disease,1400,An open multicenter study was performed to assess the efficacy and safety of alginic acid in two different dosages in 76 pediatric patients with gastroesophageal reflux confirmed by pH monitoring.,False,Is the triple '(Alginate)n treats gastroesophageal reflux disease' supported by the sentence: 'An open multicenter study was performed to assess the efficacy and safety of alginic acid in two different dosages in 76 pediatric patients with gastroesophageal reflux confirmed by pH monitoring.'?,"No, the statement does not provide direct support for the claim that ""(Alginate)n treats gastroesophageal reflux disease"". The study mentioned is about alginic acid, not (Alginate)n. Furthermore, even though it assesses efficacy and safety in pediatric patients with gastroesophageal reflux confirmed by pH monitoring, it does not explicitly state that alginic acid treats gastroesophageal reflux disease (GERD). The study could be investigating alginic acid as a preventative measure, a symptom reliever, or some other aspect of treatment. Therefore, while the study may provide indirect evidence regarding the potential benefits of alginic acid in treating GERD, it does not offer direct support for the specific claim in question." -22283339,Chlorhexidine treats Peri-Implantitis,1401,There is a need for more homogenous RCTs with large sample size to define the role of CHX in non-surgical management of peri-implant mucositis and peri-implantitis.,False,Is the triple 'Chlorhexidine treats Peri-Implantitis' supported by the sentence: 'There is a need for more homogenous RCTs with large sample size to define the role of CHX in non-surgical management of peri-implant mucositis and peri-implantitis.'?,"No, the statement does not provide direct or indirect support for the phrase ""Chlorhexidine treats Peri-Implantitis."" The statement highlights the need for more homogenous randomized controlled trials (RCTs) with larger sample sizes to clarify Chlorhexidine's (CHX) role in managing peri-implant mucositis and peri-implantitis. The existence of such a need does not confirm that Chlorhexidine effectively treats peri-implantitis; it only suggests that further investigation is required to establish its therapeutic value definitively. + + It is important to note that while Bacitracin A has been used historically as an antibiotic for topical infections, its systemic use is limited due to side effects such as nephrotoxicity (kidney damage) when administered intravenously (IV). Therefore, while there is some support for Bacitracin A having antibacterial properties that could aid in treating infections, its application should be considered in light of potential side effects and limitations. + Additionally, further studies would need to be conducted in order to establish Bacitracin A as an effective treatment for infections caused by antibiotic-resistant Gram-positive" +17678351,Bacitracin A treats bacterial infectious disease,1499,"Thus, the bacitracin and gramicidin S-based self-assembled nanopeptide ribbon may be a successful ointment formulation for bacterial infection control.",True,"'Does the phrase ""Bacitracin A treats bacterial infectious disease"" receive at least indirect support from the statement: ""Thus, the bacitracin and gramicidin S-based self-assembled nanopeptide ribbon may be a successful ointment formulation for bacterial infection control.""?","Yes, there is indirect support for the claim that ""Bacitracin A treats bacterial infectious disease"" from the statement ""Thus, the bacitracin and gramicidin S-based self-assembled nanopeptide ribbon may be a successful ointment formulation for bacterial infection control."" - The statement highlights two key factors that influence evidence-based decision-making in clinical settings: + The reason for my affirmative response is that bacitracin is explicitly mentioned in the statement as an integral component of a potential treatment for bacterial infections. Bacitracin A is one of several forms of bacitracin, all of which have antibacterial properties. Therefore, if a formulation containing bacitracin can control bacterial infections effectively, it stands to reason that bacitracin itself contributes to treating bacterial infections. - + However, it is essential to acknowledge that this support is indirect because we cannot infer that Bacitracin A alone can treat bacterial infections from the given statement. The statement refers to a combination of bacitracin and gramicidin S in nanopeptide ribbon formulation for bacterial infection control. Thus, further investigation would be necessary to isol" +11891842,Bacitracin A treats burn,1500,"Consensus was found regarding most local (topical) wound care, (SSD for clean non-facial burns, Sulfamylon (mafenide-acetate) for contaminated non-facial burns, Threolone (chloramphenicol 3% and prednisolone 0.5%) or Bacitracin for facial burns, Paraffin gauzes with or without Sulfamylon for donor and graft sites).",True,"'Does the phrase ""Bacitracin A treats burn"" receive at least indirect support from the statement: ""Consensus was found regarding most local (topical) wound care, (SSD for clean non-facial burns, Sulfamylon (mafenide-acetate) for contaminated non-facial burns, Threolone (chloramphenicol 3% and prednisolone 0.5%) or Bacitracin for facial burns, Paraffin gauzes with or without Sulfamylon for donor and graft sites).""?","Yes, the statement does provide indirect support for the claim that ""Bacitracin A treats burns."" The statement lists Bacitracin as one of the recommended treatments for facial burns, which suggests that it has some efficacy in treating burns. However, it's important to note that the statement does not provide direct evidence of Bacitracin's effectiveness in treating burns, as it only mentions its use in specific cases (facial burns). Furthermore, while Bacitracin may be an appropriate treatment in certain circumstances, it's not necessarily the best or only treatment for burns. Therefore, while the statement does lend some support to the claim, it doesn't definitively prove it." +26452786,Fenbendazole causes helminthiasis,101,The anti-ischemic mechanism of action of ranolazine in stable ischemic heart disease.,False,"'Does the phrase ""Fenbendazole causes helminthiasis"" receive at least indirect support from the statement: ""The anti-ischemic mechanism of action of ranolazine in stable ischemic heart disease.""?","No, the statement ""The anti-ischemic mechanism of action of ranolazine in stable ischemic heart disease"" does not provide any direct or indirect support for the phrase ""Fenbendazole causes helminthiasis."" These two statements discuss entirely different subjects - one is about the anti-ischemic mechanism of ranolazine in treating stable ischemic heart disease while the other is about Fenbendazole potentially causing helminthiasis (a parasitic infection caused by helminths). To establish support for a claim, there needs to be some logical connection between the evidence presented and the claim being made; in this case, no such connection exists." +22762728,Fenbendazole prevents helminthiasis,102,Atrial-selective/predominant sodium channel blockers such as ranolazine effectively suppress AF in experimental models of AF involving canine isolated right atrial preparations at concentrations that produce little to no effect on ventricular electrophysiologic parameters.,False,"'Does the phrase ""Fenbendazole prevents helminthiasis"" receive at least indirect support from the statement: ""Atrial-selective/predominant sodium channel blockers such as ranolazine effectively suppress AF in experimental models of AF involving canine isolated right atrial preparations at concentrations that produce little to no effect on ventricular electrophysiologic parameters.""?","No, the statement does not provide indirect support for the phrase ""Fenbendazole prevents helminthiasis."" The statement discusses the effects of atrial-selective/predominant sodium channel blockers, specifically ranolazine, on atrial fibrillation (AF) in canine models without making any connection to fenbendazole or helminthiasis. Helminthiasis is a condition caused by parasitic worms, which is unrelated to the electrophysiological effects discussed in the statement about AF in canine models. Therefore, there is no reasonable basis for inferring that fenbendazole prevents helminthiasis based on this statement alone." +21848143,Albendazole causes helminthiasis,103,Ranolazine has been shown to decrease angina pectoris frequency and nitroglycerin consumption.,False,"'Does the phrase ""Albendazole causes helminthiasis"" receive at least indirect support from the statement: ""Ranolazine has been shown to decrease angina pectoris frequency and nitroglycerin consumption.""?","No, the statement ""Ranolazine has been shown to decrease angina pectoris frequency and nitroglycerin consumption"" does not provide any indirect support for the claim ""Albendazole causes helminthiasis."" - 1) The importance of study design: Randomized controlled trials (RCTs) constitute one of the most robust study designs in clinical research due to their ability to minimize bias and establish cause-and-effect relationships between interventions and outcomes. + The two statements discuss different drugs (Albendazole and Ranolazine) and their effects on completely unrelated conditions (helminthiasis and angina pectoris frequency/nitroglycerin consumption). Helminthiasis is a condition caused by parasitic worms (helminths), while ranolazine is used for treating chronic angina (chest pain). Albendazole is actually an anthelmintic drug used for treating various parasitic worm infestations (helminthiasis). - + Thus, there is no connection between these two statements that would allow for one to indirectly support the other. The effect of ranolazine on angina pectoris frequency is unrelated to any potential effects of albendazole on helminthiasis." +25735916,Albendazole affects trichuriasis,104,BACKGROUND: Ranolazine has been shown to reduce myocardial ischemia and symptom severity among selected patients with chronic angina.,False,"'Does the phrase ""Albendazole affects trichuriasis"" receive at least indirect support from the statement: ""BACKGROUND: Ranolazine has been shown to reduce myocardial ischemia and symptom severity among selected patients with chronic angina.""?","No, the statement does not provide indirect support for the phrase ""Albendazole affects trichuriasis."" The background statement refers specifically to Ranolazine, its effects on myocardial ischemia, and its impact on symptom severity in certain patients with chronic angina. It does not mention Albendazole or trichuriasis at all. Therefore, there is no connection or supporting evidence that can be inferred from one statement to the other." +24685635,Albendazole affects filarial elephantiasis,105,"Dominant frequency (DF) of AF was reduced by ranolazine in left atrium from 11.7 (10.7-20.5) Hz to 7.6 (2.9-8.8) Hz (P = 0.02, n = 6).",False,"'Does the phrase ""Albendazole affects filarial elephantiasis"" receive at least indirect support from the statement: ""Dominant frequency (DF) of AF was reduced by ranolazine in left atrium from 11.7 (10.7-20.5) Hz to 7.6 (2.9-8.8) Hz (P = 0.02, n = 6).""?","No, the statement does not provide indirect support for the phrase ""Albendazole affects filarial elephantiasis."" The statement discusses the effect of ranolazine on altering dominant frequency (DF) of atrial fibrillation (AF) in left atrium; it is unrelated to albendazole or filarial elephantiasis. - 2) Sample size: Larger sample sizes increase statistical power, allowing researchers to detect smaller yet clinically significant effects that might be overlooked in smaller studies. + Filarial elephantiasis is caused by parasitic filarial worms like Wuchereria bancrofti and Brugia timori; albendazole is an anthelmintic drug used in treating these infections (World Health Organization). The statement in question, however, does not mention albendazole nor filarial elephantiasis; it only refers to ranolazine affecting AF frequency in left atrium in six patients (P < 0.05). - + Therefore, without any connection between ranolazine/AF frequency reduction in left atrium and albendazole/filarial elephantiasis treatment, there is no indirect support for the statement in question based on the provided evidence." +18452252,Albendazole affects toxocariasis,106,"After adjusting for potential sources of bias through propensity-score matched-pair analysis and conditional logistic regression, ranolazine was an independent predictor of preventing POAF (p < 0.0001).",False,"'Does the phrase ""Albendazole affects toxocariasis"" receive at least indirect support from the statement: ""After adjusting for potential sources of bias through propensity-score matched-pair analysis and conditional logistic regression, ranolazine was an independent predictor of preventing POAF (p < 0.0001).""?","No, the statement does not provide any direct or indirect support for the phrase ""Albendazole affects toxocariasis."" The statement discusses the relationship between ranolazine and preventing postoperative atrial fibrillation (POAF), not albendazole and its effects on toxocariasis. Toxocariasis is an infection caused by roundworm parasites that can affect humans; it is unrelated to ranolazine or POAF. Therefore, there is no connection between the two pieces of information provided in the statement and the claim about albendazole affecting toxocariasis." +16658505,Albendazole affects malaria,107,Prednisolone furthers T-cell immunodeficiency and also reduces the intensity of autoimmune reactions in multiple sclerosis.,False,"'Does the phrase ""Albendazole affects malaria"" receive at least indirect support from the statement: ""Prednisolone furthers T-cell immunodeficiency and also reduces the intensity of autoimmune reactions in multiple sclerosis.""?","No, the statement does not provide indirect support for the phrase ""Albendazole affects malaria."" - In" -14556561,Chlorhexidine treats pneumonia,1402,"Among patients without pneumonia at baseline, pneumonia developed in 24% (CPIS >or=6) by day 3 in those treated with chlorhexidine.",False,"Is the triple 'Chlorhexidine treats pneumonia' supported by the sentence: 'Among patients without pneumonia at baseline, pneumonia developed in 24% (CPIS >or=6) by day 3 in those treated with chlorhexidine.'?","No, the statement does not provide indirect support for the claim that ""Chlorhexidine treats pneumonia"". The study mentioned found that among patients without pneumonia at baseline, 24% developed pneumonia by day 3 when treated with chlorhexidine. This suggests that chlorhexidine may not be effective in preventing pneumonia in these patients, which contradicts the claim that it treats pneumonia. + The statement discusses the effects of Prednisolone on T-cell immunodeficiency and autoimmune reactions in multiple sclerosis. It does not mention Albendazole or malaria. Albendazole is an anthelmintic drug used to treat parasitic worm infestations, while malaria is caused by Plasmodium parasites. There is no connection implied or stated between Prednisolone, T-cell immunodeficiency, autoimmune reactions, and malaria in this statement. Therefore, it does not provide any indirect support for the claim that Albendazole affects malaria." +13946207,Albendazole affects helminthiasis,108,[Pharmacokinetics of prednisolone in adrenal insufficiency ].,False,"'Does the phrase ""Albendazole affects helminthiasis"" receive at least indirect support from the statement: ""[Pharmacokinetics of prednisolone in adrenal insufficiency ].""?","No, the statement ""Pharmacokinetics of prednisolone in adrenal insufficiency"" does not provide any direct or indirect support for the phrase ""Albendazole affects helminthiasis."" This is because they discuss different topics entirely; one focuses on pharmacokinetics of prednisolone in adrenal insufficiency, while the other refers to albendazole's effect on helminthiasis. - The statement might imply an association between chlorhexidine use and an increased risk of pneumonia development in some patients; however, it does not support chlorhexidine as a treatment for pneumonia. To establish chlorhexidine as an effective treatment for pneumonia, more extensive studies would need to be conducted that demonstrate its ability not only to prevent pneumonia but also to reduce symptoms in patients already diagnosed with pneumonia." -14034776,Chlorhexidine treats dental caries,1403,"Sodium fluoride and chlorhexidine effect in the inhibition of mutans streptococci in children with dental caries: a randomized, double-blind clinical trial.",True,"Is the triple 'Chlorhexidine treats dental caries' supported by the sentence: 'Sodium fluoride and chlorhexidine effect in the inhibition of mutans streptococci in children with dental caries: a randomized, double-blind clinical trial.'?","Yes, indirectly it does lend support. The statement mentions that chlorhexidine has an inhibitory effect on mutans streptococci in children with dental caries in the context of a randomized, double-blind clinical trial. While the statement does not explicitly claim that chlorhexidine treats dental caries, it does suggest that chlorhexidine can affect dental caries by inhibiting mutans streptococci - one of the primary bacterial species responsible for dental caries formation. + To provide further context on these terms for clarity: - The National Institutes of Health (NIH) states that chlorhexidine is an antimicrobial agent that can reduce plaque accumulation and prevent gum diseases (1). Furthermore, mutans streptococci play an essential role in dental caries pathogenesis (2). Therefore, it is reasonable to infer that chlorhexidine could potentially contribute to treating dental caries by targeting these caries-causing bacteria. However, more direct evidence would be needed for unequivocal support that chlorhexidine treats dental caries. + - Pharmacokinetics refers to what the body does to a drug after it is administered; it includes absorption, distribution, metabolism, and excretion of that drug. Prednisolone is a synthetic glucocorticoid used in various conditions such as adrenal insufficiency. - + - Helminthiasis is an infection by parasitic worms (helminths), such as roundworms (nematodes), tapeworms (cestodes), and flukes (trematodes). Albendazole is an anthelmintic drug used in treating such infections as it inhibits" +11239060,Albendazole affects filariasis,109,It is concluded that VAP is effective therapy in AIL.,False,"'Does the phrase ""Albendazole affects filariasis"" receive at least indirect support from the statement: ""It is concluded that VAP is effective therapy in AIL.""?","No, the statement ""It is concluded that VAP is effective therapy in AIL"" does not provide direct or indirect support for the phrase ""Albendazole affects filariasis."" - References: + The conclusion that VAP (presumably referring to some form of treatment) is effective therapy in AIL (Assistant Investigator Led trials) does not make any reference to Albendazole, filariasis, or their relationship. Filariasis is a parasitic disease caused by roundworms of the Filarioidea type, whereas Albendazole is an anthelmintic medication used to treat various parasitic worm infestations. - 1. National Center for Bi" -13966318,Chlorhexidine treats bacterial infectious disease with sepsis,1404,"All patients with B. stabilis bacteraemia had indwelling intravenous catheters, which were treated with chlorhexidine to disinfect the catheters.",False,"Is the triple 'Chlorhexidine treats bacterial infectious disease with sepsis' supported by the sentence: 'All patients with B. stabilis bacteraemia had indwelling intravenous catheters, which were treated with chlorhexidine to disinfect the catheters.'?","No, the statement does not provide direct or indirect support for the phrase ""Chlorhexidine treats bacterial infectious disease with sepsis."" The statement only mentions that chlorhexidine is used to disinfect indwelling intravenous catheters in patients with B. stabilis bacteraemia, but it does not indicate that chlorhexidine treats bacterial infectious disease with sepsis. Chlorhexidine is an antiseptic commonly used for skin disinfection and catheter care, but it is not typically used as a treatment for systemic bacterial infections or sepsis in patients." -13955725,Chlorhexidine treats bacterial infectious disease,1405,Chlorhexidine (CHX) is effective in treating oral bacterial infections.,True,Is the triple 'Chlorhexidine treats bacterial infectious disease' supported by the sentence: 'Chlorhexidine (CHX) is effective in treating oral bacterial infections.'?,"Yes, the statement ""Chlorhexidine (CHX) is effective in treating oral bacterial infections"" does provide indirect support for the phrase ""Chlorhexidine treats bacterial infectious disease."" This is because oral infections represent a subset of bacterial infectious diseases, and if Chlorhexidine has been shown to be effective in treating oral bacterial infections specifically, it suggests that Chlorhexidine may have general applicability in treating other forms of bacterial infections as well. + The lack of connection between the two statements means that one cannot be inferred from the other without additional information linking Albendazole, filariasis, and VAP/AIL." +24729219,Albendazole disrupts helminthiasis,110,A thermographic assessment of three intra-articular prednisolone analogues given in rheumatoid synovitis.,False,"'Does the phrase ""Albendazole disrupts helminthiasis"" receive at least indirect support from the statement: ""A thermographic assessment of three intra-articular prednisolone analogues given in rheumatoid synovitis.""?","No, the statement ""A thermographic assessment of three intra-articular prednisolone analogues given in rheumatoid synovitis"" does not provide indirect support for the phrase ""Albendazole disrupts helminthiasis."" - + The statement is about a thermographic assessment of three intra-articular prednisolone analogues used in rheumatoid synovitis, which is unrelated to albendazole or helminthiasis. Helminthiasis refers to diseases caused by parasitic worms, while albendazole is an antiparasitic drug used primarily for treating these types of infections. - However, it is important to note that direct support would require evidence specifically addressing bacterial infections outside the oral cavity. Indirect support from one specific application does not necessarily imply that Chlorhexidine will be effective in all cases of bacterial infectious disease, as different types of infections may respond differently to treatment. + The lack of connection between these two concepts makes it impossible for one statement to indirectly support the other. It is essential to evaluate each claim based on its specific context and evidence rather than drawing unsupported conclusions from unrelated studies or statements." +16658503,Albendazole disrupts malaria,111,The effect of small doses of prednisolone on the incidence of subcutaneous sarcomas induced by 3-methylcholanthrene in virgin female Swiss mice.,False,"'Does the phrase ""Albendazole disrupts malaria"" receive at least indirect support from the statement: ""The effect of small doses of prednisolone on the incidence of subcutaneous sarcomas induced by 3-methylcholanthrene in virgin female Swiss mice.""?","No, the statement does not provide any direct or indirect support for the phrase ""Albendazole disrupts malaria."" - + The statement discusses the effect of small doses of prednisolone on the incidence of subcutaneous sarcomas induced by 3-methylcholanthrene in virgin female Swiss mice. This study focuses on cancer incidence in mice treated with prednisolone and 3-methylcholanthrene, which is far removed from the topic of malaria disruption by Albendazole. - It is also crucial to consider potential side effects and contraindications associated with Chlorhexidine use when interpreting its efficacy in treating bacterial infections more broadly. Further research would be required to establish the generalizability of these findings beyond oral bacterial infections specifically." -13614413,Chlorhexidine treats stomatitis,1406,CONCLUSIONS: The frequency and duration of OM are significantly improved by prophylactic chlorhexidine and by cryotherapy.,True,Is the triple 'Chlorhexidine treats stomatitis' supported by the sentence: 'CONCLUSIONS: The frequency and duration of OM are significantly improved by prophylactic chlorhexidine and by cryotherapy.'?,"Yes, the statement ""CONCLUSIONS: The frequency and duration of OM are significantly improved by prophylactic chlorhexidine and by cryotherapy"" does provide indirect support for the phrase ""Chlorhexidine treats stomatitis."" This is because stomatitis falls under the category of oral mucositis (OM), which is what the study is investigating. If chlorhexidine reduces both the frequency and duration of OM, it can be inferred that chlorhexidine could help treat stomatitis as well. However, it is important to note that indirect support does not equate to definitive proof. Further investigation would be necessary to make a direct causal link between chlorhexidine use and stomatitis treatment." -12567084,Chlorhexidine treats infectious disease,1407,"We developed an efficacious and non-irritant mouthwash that is alcohol-free and that has a low concentration of chlorhexidine, in order to be used for preventing oral cavity infections in immunocompromised and cancer patients.",True,"Is the triple 'Chlorhexidine treats infectious disease' supported by the sentence: 'We developed an efficacious and non-irritant mouthwash that is alcohol-free and that has a low concentration of chlorhexidine, in order to be used for preventing oral cavity infections in immunocompromised and cancer patients.'?","Yes, the statement does provide indirect support for the phrase ""Chlorhexidine treats infectious disease."" The development of an efficacious mouthwash containing chlorhexidine suggests that chlorhexidine has antimicrobial properties that can help prevent infections in high-risk populations like immunocompromised and cancer patients. Since infectious diseases often result from microbial infections, it can be inferred that chlorhexidine plays a role in treating infectious diseases indirectly by reducing microbial load. However, it is important to note that direct evidence from clinical trials or studies specifically examining chlorhexidine's impact on infectious diseases would provide stronger support for the claim that chlorhexidine treats infectious diseases." -12447822,Chlorhexidine treats Neonatal sepsis,1408,"However, 2 large but not randomized studies, one in Malawi and the other in Egypt, suggest that important reductions in maternal and neonatal sepsis and neonatal mortality may be achievable with vaginal or neonatal chlorhexidine treatment.",True,"Is the triple 'Chlorhexidine treats Neonatal sepsis' supported by the sentence: 'However, 2 large but not randomized studies, one in Malawi and the other in Egypt, suggest that important reductions in maternal and neonatal sepsis and neonatal mortality may be achievable with vaginal or neonatal chlorhexidine treatment.'?","Yes, indirectly it does support that statement because chlorhexidine is being associated with reduced instances of maternal and neonatal sepsis as well as neonatal mortality in two large-scale studies conducted in Malawi and Egypt. The statement does not specify whether it is through vaginal or neonatal treatment; however, it does imply that chlorhexidine has some positive impact on neonatal sepsis treatment. + To establish indirect support, there should be some common ground between the two pieces of information that allows one to inform the other. However, in this case, there is no overlap in terms of subject matter (malaria vs. sarcomas in mice), substances involved (Albendazole vs. prednisolone and 3-methylcholanthrene), or study outcomes (disruption of malaria vs. cancer incidence). Therefore, it is not possible to infer any meaningful relationship between these two statements that would lend credence to the claim ""Albendazole disrupts mal" +13637338,Albendazole disrupts Hookworm Infections,112,[Effects of chromocarb diethylamine and prednisolone in experimental uveitis induced by clove oil in rabbits].,False,"'Does the phrase ""Albendazole disrupts Hookworm Infections"" receive at least indirect support from the statement: ""[Effects of chromocarb diethylamine and prednisolone in experimental uveitis induced by clove oil in rabbits].""?","No, the statement ""Effects of chromocarb diethylamine and prednisolone in experimental uveitis induced by clove oil in rabbits"" does not provide indirect support for the phrase ""Albendazole disrupts Hookworm Infections."" - - The statement itself is not definitive proof that chlorhexidine treats neonatal sepsis since it comes from observational studies and not randomized controlled trials (RCTs). However, these large-scale studies do provide valuable insights into potential benefits, which can be used as preliminary evidence for further investigation in RCTs. + The statement in question is an experimental study on uveitis (inflammation of the uvea) in rabbits induced by clove oil, investigating the effects of two different drugs - chromocarb diethylamine and prednisolone. This study does not involve Albendazole nor does it investigate hookworm infections in any capacity. Therefore, it does not provide any relevant information or indirect support for the claim that Albendazole disrupts hookworm infections. - - In conclusion, while not definitive proof, these studies offer support for chlorhexidine as an agent that could contribute towards neonatal sepsis treatment when used either vaginally or neonatally. This is an important area for future research as it may lead to improved neonatal healthcare outcomes." -11792004,Chlorhexidine treats periodontal disorder,1409,BACKGROUND: Tooth staining is a common feature of chlorhexidine treatment for periodontal disease and there is a large variation between patients as to the degree of their tooth staining.,False,Is the triple 'Chlorhexidine treats periodontal disorder' supported by the sentence: 'BACKGROUND: Tooth staining is a common feature of chlorhexidine treatment for periodontal disease and there is a large variation between patients as to the degree of their tooth staining.'?,"No, the statement ""Chlorhexidine treats periodontal disorder"" does not receive indirect support from the provided background information. The background statement discusses a side effect (tooth staining) associated with chlorhexidine treatment for periodontal disease, but it does not provide evidence that chlorhexidine effectively treats periodontal disorder. Therefore, no conclusion can be drawn regarding the treatment efficacy based solely on this background information." -10593306,Chlorhexidine treats eye infectious disorder,1410,Clinical trial of chlorhexidine and diaminodiphenylsulphone in superficial ocular infections.,True,Is the triple 'Chlorhexidine treats eye infectious disorder' supported by the sentence: 'Clinical trial of chlorhexidine and diaminodiphenylsulphone in superficial ocular infections.'?,"Yes, indirectly it does support the statement that chlorhexidine treats eye infectious disorders. The clinical trial mentioned in the statement indicates that chlorhexidine was used in a study related to ocular infections, implying its potential application as a treatment. However, without specific results from the trial, we cannot conclusively say that chlorhexidine is effective in treating eye infections based solely on this information." -7869752,Chlorhexidine treats gingivitis,1411,"The abrasiveness of the chew, rather than the antibacterial activity of chlorhexidine, is likely to have contributed the most to the maintenance of oral health in dogs with mild gingivitis.",False,"Is the triple 'Chlorhexidine treats gingivitis' supported by the sentence: 'The abrasiveness of the chew, rather than the antibacterial activity of chlorhexidine, is likely to have contributed the most to the maintenance of oral health in dogs with mild gingivitis.'?","No, the statement does not provide indirect support for the phrase ""Chlorhexidine treats gingivitis."" The given statement suggests that an abrasive property of a chew is primarily responsible for maintaining oral health in dogs with mild gingivitis, rather than chlorhexidine's antibacterial activity. This implies that chlorhexidine may not be the main factor in treating gingivitis in dogs, which contradicts the claim that chlorhexidine treats gingivitis." -7287519,Chlorhexidine treats periodontitis,1412,Assessing the effectiveness of locally delivered chlorhexidine in the treatment of periodontitis.,True,Is the triple 'Chlorhexidine treats periodontitis' supported by the sentence: 'Assessing the effectiveness of locally delivered chlorhexidine in the treatment of periodontitis.'?,"Yes, the statement ""Assessing the effectiveness of locally delivered chlorhexidine in the treatment of periodontitis"" does provide indirect support for the phrase ""Chlorhexidine treats periodontitis."" This is because it implies that chlorhexidine is being used as an intervention for periodontitis, which suggests that it has some level of efficacy in treating the condition. However, it is important to note that this does not constitute direct evidence; further investigation would be required to establish a definitive causal relationship between chlorhexidine use and improvements in periodontitis symptoms." -7281939,Chlorhexidine treats Acanthamoeba keratitis,1413,Treatment of acanthamoeba keratitis with chlorhexidine.,True,Is the triple 'Chlorhexidine treats Acanthamoeba keratitis' supported by the sentence: 'Treatment of acanthamoeba keratitis with chlorhexidine.'?,"Yes, the statement ""Treatment of acanthamoeba keratitis with chlorhexidine"" does provide indirect support for the phrase ""Chlorhexidine treats Acanthamoeba keratitis."" This is because treatment generally implies that there is an effect observed in resolving or alleviating the condition (in this case Acanthamoeba keratitis), which suggests that chlorhexidine has some therapeutic benefit against this specific infection. However, it is important to note that indirect support does not necessarily equate to definitive proof; further investigation would be required to establish a direct causal relationship between chlorhexidine usage and successful treatment outcomes for Acanthamoeba keratitis." -22179313,Nicergoline treats depressive disorder,1414,"The Efficacy of Sertraline, Escitalopram, and Nicergoline in the Treatment of Depression and Apathy in Alzheimer's Disease: The Okayama Depression and Apathy Project (ODAP).BACKGROUND: Neuropsychiatric symptoms of dementia such as depression and apathy in patients with Alzheimer's disease (AD) are associated with a lower quality of life.",False,"Is the triple 'Nicergoline treats depressive disorder' supported by the sentence: 'The Efficacy of Sertraline, Escitalopram, and Nicergoline in the Treatment of Depression and Apathy in Alzheimer's Disease: The Okayama Depression and Apathy Project (ODAP).BACKGROUND: Neuropsychiatric symptoms of dementia such as depression and apathy in patients with Alzheimer's disease (AD) are associated with a lower quality of life.'?","No, the statement does not provide direct support for the claim that Nicergoline treats depressive disorder. The Okayama Depression and Apathy Project (ODAP) study mentioned in the statement investigates the efficacy of Sertraline, Escitalopram, and Nicergoline in treating depression and apathy in Alzheimer's disease patients. However, it does not explicitly state that Nicergoline is effective in treating depressive disorder in general population without Alzheimer's disease. Further investigation is required to make such conclusions about Nicergoline's effectiveness in treating depressive disorders outside of Alzheimer's disease context." -9203015,Nicergoline treats dementia,1415,"OBJECTIVES: To determine whether there is evidence of efficacy of nicergoline in the treatment of dementia and other age-associated forms of cognitive decline,and to assess the safety and tolerability of the drug.",False,"Is the triple 'Nicergoline treats dementia' supported by the sentence: 'OBJECTIVES: To determine whether there is evidence of efficacy of nicergoline in the treatment of dementia and other age-associated forms of cognitive decline,and to assess the safety and tolerability of the drug.'?","No, the phrase ""Nicergoline treats dementia"" does not receive direct support from the statement provided. The statement describes an objective to determine if there is evidence of efficacy (treatment effect) of nicergoline in treating dementia and other forms of cognitive decline, as well as assessing its safety and tolerability. However, it does not confirm that nicergoline treats dementia; it only mentions that there is an intention to investigate its potential as a treatment option. The actual results and evidence from such a study would need to be evaluated for definitive support." -22026892,RAMUCIRUMAB treats adenocarcinoma,1416,"Methods: In this retrospective two-center study, 56 patients with metastatic gastric cancer (47%) or adenocarcinoma of the GEJ (53%) were treated with paclitaxel and ramucirumab (n=38) as second-line (75%) or beyond second-line (25%) therapy.",False,"Is the triple 'RAMUCIRUMAB treats adenocarcinoma' supported by the sentence: 'Methods: In this retrospective two-center study, 56 patients with metastatic gastric cancer (47%) or adenocarcinoma of the GEJ (53%) were treated with paclitaxel and ramucirumab (n=38) as second-line (75%) or beyond second-line (25%) therapy.'?","No, the statement does not provide direct support for the claim that ""RAMUCIRUMAB treats adenocarcinoma"". The statement describes a retrospective study where patients with metastatic gastric cancer or adenocarcinoma of the gastroesophageal junction (GEJ) were treated with paclitaxel and ramucirumab as second-line or beyond second-line therapy. However, it does not specify whether ramucirumab was effective in treating adenocarcinoma in these patients. Therefore, it only provides indirect evidence at best, as it suggests that ramucirumab was used in treating adenocarcinoma but does not confirm its efficacy in doing so." -21622108,RAMUCIRUMAB treats non-small cell lung carcinoma,1417,This study aimed to validate the primary prophylactic use of pegfilgrastim with docetaxel and ramucirumab treatment in Japanese patients with NSCLC.,True,Is the triple 'RAMUCIRUMAB treats non-small cell lung carcinoma' supported by the sentence: 'This study aimed to validate the primary prophylactic use of pegfilgrastim with docetaxel and ramucirumab treatment in Japanese patients with NSCLC.'?,"Yes, indirect support can be inferred from the statement provided. The study aims to validate the use of ramucirumab in combination with docetaxel for primary prophylactic purposes in Japanese patients with non-small cell lung carcinoma (NSCLC). This suggests that ramucirumab is being investigated for its potential therapeutic benefits in treating NSCLC, even though it does not explicitly state that ramucirumab treats NSCLC on its own. However, it is important to note that further investigation is necessary to establish direct evidence for ramucirumab's efficacy in treating NSCLC independently." -21474987,RAMUCIRUMAB treats hepatocellular carcinoma,1418,Cost-effectiveness analysis of ramucirumab treatment for patients with hepatocellular carcinoma who progressed on sorafenib with alpha-fetoprotein concentrations of at least 400 ng/ml.,True,Is the triple 'RAMUCIRUMAB treats hepatocellular carcinoma' supported by the sentence: 'Cost-effectiveness analysis of ramucirumab treatment for patients with hepatocellular carcinoma who progressed on sorafenib with alpha-fetoprotein concentrations of at least 400 ng/ml.'?,"Yes, indirect support can be inferred from the statement provided. The key term here is ""indirect support,"" which means that while the statement does not explicitly confirm that ramucirumab treats hepatocellular carcinoma (HCC), it does suggest that ramucirumab is being studied as a potential treatment for HCC patients who have progressed on sorafenib therapy. - - Specifically, the statement refers to a cost-effectiveness analysis of ramucirumab treatment for patients with HCC who have progressed on sorafenib therapy and have alpha-fetoprotein concentrations of at least 400 ng/ml. This implies that ramucirumab is being considered as an option for treating these patients, as cost-effectiveness analyses typically evaluate interventions that have some potential for being beneficial in practice. - - However, it is important to note that indirect support does not equate to definitive proof or direct evidence that ramucirumab treats HCC. Additional studies and evidence would be required to establish such a claim conclusively." -23342893,TAFASITAMAB treats diffuse large B-cell lymphoma,1419,Lenalidomide was recently approved in combination with the anti-monoclonal B-cell antibody tafasitamab for patients with relapsed DLBCL after 1 to 3 previous treatments.,True,Is the triple 'TAFASITAMAB treats diffuse large B-cell lymphoma' supported by the sentence: 'Lenalidomide was recently approved in combination with the anti-monoclonal B-cell antibody tafasitamab for patients with relapsed DLBCL after 1 to 3 previous treatments.'?,"Yes, indirectly it does support that tafasitamab treats diffuse large B-cell lymphoma (DLBCL). The statement indicates that lenalidomide was approved in combination with tafasitamab for patients with relapsed DLBCL after 1 to 3 previous treatments. This implies that tafasitamab is an active component in treating DLBCL, even though the primary focus of the statement is on lenalidomide. However, it is essential to note that tafasitamab's efficacy in treating DLBCL is established in conjunction with lenalidomide in this specific context, rather than as a standalone treatment." -22828138,Thioctic acid treats cystinuria,1420,Tolvaptan and a-Lipoic acid were also tested in patients with cystinuria and resulted in reduction of recurrence.,True,Is the triple 'Thioctic acid treats cystinuria' supported by the sentence: 'Tolvaptan and a-Lipoic acid were also tested in patients with cystinuria and resulted in reduction of recurrence.'?,"Yes, there is indirect support for the statement ""Thioctic acid treats cystinuria"" based on the provided evidence. The statement ""Tolvaptan and a-Lipoic acid were also tested in patients with cystinuria and resulted in reduction of recurrence"" suggests that two different compounds were found effective in treating cystinuria (a kidney stone disorder caused by an amino acid metabolism defect). The term ""a-Lipoic acid"" is another name for Thioctic acid. Therefore, since Thioctic acid (a-Lipoic acid) was found effective in reducing cystinuria recurrence in patients, it indirectly supports the claim that Thioctic acid treats cystinuria. However, it is important to note that more extensive clinical trials would be needed for definitive conclusions regarding its therapeutic efficacy in treating cystinuria." -21111424,Thioctic acid treats optic neuritis,1421,"Conclusion: Six weeks of oral lipoic acid supplementation after acute optic neuritis is safe and well tolerated; however, because of insufficient recruitment, we could not conclude that lipoic acid treatment was neuroprotective in acute optic neuritis.",False,"Is the triple 'Thioctic acid treats optic neuritis' supported by the sentence: 'Conclusion: Six weeks of oral lipoic acid supplementation after acute optic neuritis is safe and well tolerated; however, because of insufficient recruitment, we could not conclude that lipoic acid treatment was neuroprotective in acute optic neuritis.'?","No, the phrase ""Thioctic acid treats optic neuritis"" does not receive indirect support from the statement provided. The statement discusses a study on oral lipoic acid supplementation after acute optic neuritis, but it does not provide evidence that lipoic acid (also known as thioctic acid) has any therapeutic effect on optic neuritis. Instead, it only concludes that such supplementation is safe and well-tolerated in patients with acute optic neuritis. The study did not find sufficient evidence to conclude that lipoic acid treatment was neuroprotective in acute optic neuritis due to insufficient recruitment for statistical power. Thus, there is no support for thioctic acid treating optic neuritis based on the given statement." -14414806,Thioctic acid treats carpal tunnel syndrome,1422,Treatment of carpal tunnel syndrome with alpha-lipoic acid.,True,Is the triple 'Thioctic acid treats carpal tunnel syndrome' supported by the sentence: 'Treatment of carpal tunnel syndrome with alpha-lipoic acid.'?,"Yes, there is indirect support for the statement ""Thioctic acid treats carpal tunnel syndrome"" based on the provided information that alpha-lipoic acid can be used in its treatment. Thioctic acid is another name for alpha-lipoic acid; therefore, it can be inferred that thioctic acid may also be effective in treating carpal tunnel syndrome. However, it is important to note that further investigation would be necessary to establish direct causality and understand potential side effects or limitations associated with using thioctic acid specifically for carpal tunnel syndrome treatment." -11271151,Thioctic acid treats skin disorder,1423,Alpha-Lipoic acid-based PPARgamma agonists for treating inflammatory skin diseases.,True,Is the triple 'Thioctic acid treats skin disorder' supported by the sentence: 'Alpha-Lipoic acid-based PPARgamma agonists for treating inflammatory skin diseases.'?,"Yes, there is indirect support for the statement ""Thioctic acid treats skin disorder"" from the provided evidence: ""Alpha-Lipoic acid-based PPARgamma agonists for treating inflammatory skin diseases."" + It is essential to evaluate scientific literature in context, considering both the specific subject matter of the study as well as its methodology. Only then can one draw valid conclusions or identify potential connections between different pieces of research." +15248433,Albendazole prevents filariasis,113,[Effect of prednisolone and heparin on circulating T- and B-lymphocytes in glomerulonephritis and systemic lupus erythematosus].,False,"'Does the phrase ""Albendazole prevents filariasis"" receive at least indirect support from the statement: ""[Effect of prednisolone and heparin on circulating T- and B-lymphocytes in glomerulonephritis and systemic lupus erythematosus].""?","No, the statement does not provide any direct or indirect support for the claim that ""Albendazole prevents filariasis."" The statement focuses on the effects of prednisolone and heparin on circulating T- and B-lymphocytes in glomerulonephritis and systemic lupus erythematosus. It does not mention Albendazole or filariasis at all. Therefore, it does not contribute any evidence for or against the claim in question. - + To further elaborate, filariasis is a parasitic disease caused by microscopic, thread-like worms. Albendazole is an anthelmintic drug often used in the treatment of filariasis because it kills the parasitic worms in the lymphatic system and reduces the number of microfilariae (immature worms) in the blood. However, preventing filariasis would typically involve preventative measures such as mass drug administration programs in endemic areas or personal protective measures against mosquito bites, as filariasis is transmitted by mosquitoes. The statement provided does not discuss any of these topics." +13732336,Albendazole prevents helminthiasis,114,[Effects of prednisolone on thyroidal-123I uptake in subacute thyroiditis].,False,"'Does the phrase ""Albendazole prevents helminthiasis"" receive at least indirect support from the statement: ""[Effects of prednisolone on thyroidal-123I uptake in subacute thyroiditis].""?","No, the statement does not provide any direct or indirect support for the claim that Albendazole prevents helminthiasis. The statement in question discusses the effects of prednisolone on thyroidal-123I uptake in subacute thyroiditis, which is unrelated to the pharmacological effects of Albendazole on helminthiasis (parasitic worm infections)." +15316470,Ibuprofen subclass of 2-Hydroxyibuprofen,115,"Blood Eosinophil Depletion with Mepolizumab, Benralizumab and Prednisolone in Eosinophilic Asthma.",False,"'Does the phrase ""Ibuprofen subclass of 2-Hydroxyibuprofen"" receive at least indirect support from the statement: ""Blood Eosinophil Depletion with Mepolizumab, Benralizumab and Prednisolone in Eosinophilic Asthma.""?","No, the statement ""Blood Eosinophil Depletion with Mepolizumab, Benralizumab and Prednisolone in Eosinophilic Asthma"" does not provide indirect support for the phrase ""Ibuprofen subclass of 2-Hydroxyibuprofen"". The statement discusses the use of certain medications (Mepolizumab, Benralizumab, and Prednisolone) in depleting blood eosinophils in individuals with eosinophilic asthma. Ibuprofen and 2-Hydroxyibuprofen are both nonsteroidal anti-inflammatory drugs (NSAIDs), but there is no mention of either in the provided statement, nor is there any connection made between these drugs and eosinophil depletion in asthma patients. The two concepts remain unrelated in this context." +16265626,Ibuprofen related to Arthralgia,116,[Prednisolone and aspirin combination therapy in habitual abortion with autoantibodies].,False,"'Does the phrase ""Ibuprofen related to Arthralgia"" receive at least indirect support from the statement: ""[Prednisolone and aspirin combination therapy in habitual abortion with autoantibodies].""?","No, the phrase ""Ibuprofen related to Arthralgia"" does not receive indirect support from the statement ""[Prednisolone and aspirin combination therapy in habitual abortion with autoantibodies]."" - The key term that provides indirect support is ""Alpha-Lipoic acid."" Alpha-Lipoic acid is also known as Thioctic acid (1). Thioctic acid has antioxidant properties (2), which can help protect skin cells from damage (3). Moreover, it has been shown that Thioctic acid can act as a PPAR-gamma agonist (4), which is a target for treating inflammatory skin diseases (5). Therefore, based on these connections between Alpha-Lipoic acid (Thioctic acid) and its potential benefits for treating inflammatory skin disorders, one could infer indirect support for the initial claim that Thioctic acid treats skin disorders. + The statement discusses a combination therapy of prednisolone and aspirin for habitual abortion in patients with autoantibodies. It does not mention ibuprofen at all, let alone its relation to arthralgia (joint pain). Therefore, there is no indirect support for the claim that ibuprofen is related to arthralgia in this statement. - + Arthralgia can be a side effect of non-steroidal anti-inflammatory drugs (NSAIDs) like ibuprofen, but this statement does not provide evidence for that relationship in this context. It is important to base our understanding on direct evidence rather than assuming indirect associations without explicit mention in the text." +14582794,Ibuprofen related to Pain,117,"To illustrate this, we used an example of cost-effectiveness analysis for docetaxel in combination with prednisolone in metastatic hormone-refractory prostate cancer.",False,"'Does the phrase ""Ibuprofen related to Pain"" receive at least indirect support from the statement: ""To illustrate this, we used an example of cost-effectiveness analysis for docetaxel in combination with prednisolone in metastatic hormone-refractory prostate cancer.""?","No, the phrase ""Ibuprofen related to Pain"" does not receive indirect support from the statement provided. The statement discusses a cost-effectiveness analysis for docetaxel in combination with prednisolone in metastatic hormone-refractory prostate cancer. This topic is unrelated to ibuprofen, which is a non-prescription nonsteroidal anti-inflammatory drug (NSAID) commonly used for relieving pain, fever, and inflammation. The lack of connection between the two statements makes it impossible for the first statement to receive indirect support from the second statement." +11440746,Ibuprofen related to Toothache,118,Prednisolone is associated with a worse bone mineral density in primary adrenal insufficiency.,False,"'Does the phrase ""Ibuprofen related to Toothache"" receive at least indirect support from the statement: ""Prednisolone is associated with a worse bone mineral density in primary adrenal insufficiency.""?","No, the statement ""Prednisolone is associated with worse bone mineral density in primary adrenal insufficiency"" does not provide indirect support for the phrase ""Ibuprofen related to toothache."" The two statements discuss different medications (Ibuprofen vs Prednisolone) and different health conditions (toothache vs primary adrenal insufficiency and bone mineral density). Therefore, there is no logical connection between them that would allow for indirect support." +9106384,Ibuprofen related to osteoarthritis,119,CONCLUSIONS: Prednisolone was more effective in inducing response than itraconazole in acute-stage ABPA.,False,"'Does the phrase ""Ibuprofen related to osteoarthritis"" receive at least indirect support from the statement: ""CONCLUSIONS: Prednisolone was more effective in inducing response than itraconazole in acute-stage ABPA.""?","No, there is no indirect support for the phrase ""Ibuprofen related to osteoarthritis"" from the statement ""CONCLUSIONS: Prednisolone was more effective in inducing response than itraconazole in acute-stage ABPA."" - 1) https://www.ncbi.nlm.nih.gov/books/NBK557845/ - 2) https://www.ncbi.nl" -9864403,Thioctic acid treats multiple sclerosis,1424,"For study of antioxidant therapy efficiency in relapsing-remitting multiple sclerosis we investigated group 1 (18 patients) treated with alpha-lipoic acid and group 2 (14 patients) who received complex of antioxidants and neuroprotectors with various mechanisms of action (oc-lipoic acid, Nicotinamide, Acetylcysteine, Triovit Beta-carotine, Alpha-tocopheryl acetate, Ascorbic acid, Selenium, Pentoxifylline, Cerebrolysin, Amantadine hydrochloride) during 1 month, 2 times a year.",False,"Is the triple 'Thioctic acid treats multiple sclerosis' supported by the sentence: 'For study of antioxidant therapy efficiency in relapsing-remitting multiple sclerosis we investigated group 1 (18 patients) treated with alpha-lipoic acid and group 2 (14 patients) who received complex of antioxidants and neuroprotectors with various mechanisms of action (oc-lipoic acid, Nicotinamide, Acetylcysteine, Triovit Beta-carotine, Alpha-tocopheryl acetate, Ascorbic acid, Selenium, Pentoxifylline, Cerebrolysin, Amantadine hydrochloride) during 1 month, 2 times a year.'?","No, the statement does not provide indirect support for the claim that thioctic acid (also known as alpha-lipoic acid) treats multiple sclerosis (MS). The statement describes a study where two groups of patients were given different antioxidant treatments for relapsing-remitting MS. Group 1 received alpha-lipoic acid (thioctic acid), while group 2 received a complex of antioxidants and neuroprotectors that included thioctic acid among other substances. - - However, there is no mention in the statement about the efficacy of thioctic acid specifically in treating MS. The study does not compare thioctic acid treatment to a placebo or another treatment, so it is impossible to determine whether thioctic acid has any effect on MS symptoms based on this information alone. - - In order for there to be indirect support for the claim that thioctic acid treats MS, there should be some evidence suggesting that patients in group 1 had" -8933101,Thioctic acid treats Alzheimer disease,1425,"Despite the fact that this study was small and not randomized, this is the first indication that treatment with alpha-lipoic acid might be a successful 'neuroprotective' therapy option for AD and related dementias.",False,"Is the triple 'Thioctic acid treats Alzheimer disease' supported by the sentence: 'Despite the fact that this study was small and not randomized, this is the first indication that treatment with alpha-lipoic acid might be a successful 'neuroprotective' therapy option for AD and related dementias.'?","No, the phrase ""Thioctic acid treats Alzheimer disease"" does not receive direct or indirect support from the statement provided. The statement refers specifically to alpha-lipoic acid (also known as alpha-lipoic acid or ALA) as a potential neuroprotective therapy option for Alzheimer's disease (AD) and related dementias. Thioctic acid is another name for ALA, but the statement does not explicitly connect ALA treatment to a cure for AD; it only suggests that it might be a successful neuroprotective therapy option. Furthermore, the study mentioned is described as small and not randomized, which implies that more research is needed before definitive conclusions can be drawn about ALA's effectiveness in treating AD." -8739967,Thioctic acid treats hypertensive disorder,1426,"STZ-diabetes resulted in increased blood pressure, which was partially improved by alpha-lipoic acid treatment.",False,"Is the triple 'Thioctic acid treats hypertensive disorder' supported by the sentence: 'STZ-diabetes resulted in increased blood pressure, which was partially improved by alpha-lipoic acid treatment.'?","No, the statement does not provide direct or indirect support for the claim that ""Thioctic acid treats hypertensive disorder."" The study referenced in the statement investigates streptozotocin-induced diabetes (STZ-diabetes) in rats and its impact on blood pressure, as well as the effects of alpha-lipoic acid treatment on blood pressure. While thioctic acid is another name for alpha-lipoic acid, there is no mention in the statement that thioctic acid specifically treats hypertensive disorders. The statement only suggests that alpha-lipoic acid may have some beneficial effects on blood pressure in diabetic rats, which does not necessarily translate to treating hypertension in humans. - - Additionally, it is important to consider that studies conducted in animal models do not always yield comparable results in human trials due to differences in physiology, genetics, and environmental factors. Therefore, drawing conclusions based on animal studies should be done cautiously, considering their limitations in predicting human outcomes. - - In summary, while alpha-lipoic acid may have some impact on blood pressure in diabetic rats, it does not provide direct evidence that" -7865558,Thioctic acid treats type 2 diabetes mellitus,1427,"AIMS: Thioctic acid (TA), glibenclamide and acarbose are widely used to either alone or concomitantly treat patients suffering from noninsulin-dependent diabetes (NIDDM).",False,"Is the triple 'Thioctic acid treats type 2 diabetes mellitus' supported by the sentence: 'AIMS: Thioctic acid (TA), glibenclamide and acarbose are widely used to either alone or concomitantly treat patients suffering from noninsulin-dependent diabetes (NIDDM).'?","No, the statement does not provide direct support for the claim that ""Thioctic acid treats type 2 diabetes mellitus"". The AIMS statement only mentions that Thioctic acid (TA), along with glibenclamide and acarbose, is used in treating patients with noninsulin-dependent diabetes (NIDDM), which is another term for type 2 diabetes mellitus. However, it does not specify that TA treats type 2 diabetes mellitus; it only states that it is used in its treatment regimen either alone or in combination with other drugs. To support the claim that Thioctic acid treats type 2 diabetes mellitus, there would need to be evidence demonstrating its specific therapeutic effect on the disease." -7603474,Thioctic acid treats diabetic neuropathy,1428,"A two-central randomised single-blind placebo-controlled study was conducted to assess efficacy of intravenous administration of trometamol salt of thioctic (alpha-lipoic) acid (Thioctacid 600, ""ASTA Medica"", Germany) in 200 ml of physiological solution in 40 non-insulin dependent diabetic patients with symptomatic diabetic neuropathy.",True,"Is the triple 'Thioctic acid treats diabetic neuropathy' supported by the sentence: 'A two-central randomised single-blind placebo-controlled study was conducted to assess efficacy of intravenous administration of trometamol salt of thioctic (alpha-lipoic) acid (Thioctacid 600, ""ASTA Medica"", Germany) in 200 ml of physiological solution in 40 non-insulin dependent diabetic patients with symptomatic diabetic neuropathy.'?","Yes, the statement does provide indirect support for the claim that thioctic acid treats diabetic neuropathy. The study described is a randomised single-blind placebo-controlled trial, which is a robust experimental design that minimizes bias and allows for causal inferences. The fact that it was conducted on non-insulin dependent diabetic patients with symptomatic diabetic neuropathy who were administered thioctic acid (also known as alpha-lipoic acid) specifically indicates that the researchers were studying the potential effects of thioctic acid on diabetic neuropathy. - - However, it is important to note that while this study design provides some level of support for the claim, it does not constitute definitive proof that thioctic acid treats diabetic neuropathy. The results of the study would need to be analyzed in detail to determine whether thioctic acid had a statistically significant positive effect compared to the placebo group. Additionally, even if the study found a significant effect, it would only apply to the specific population studied (non-insulin dependent diabetic patients), dosage used (600 mg), and route of administration (intravenous). Therefore," -21616335,Ampicillin treats Infection,1429,"Penicillin Allergy in Pregnancy: Moving From ""Rash"" Decisions to Accurate Diagnosis.The emergence of beta-lactam-resistant pathogenic organisms has resulted in limitation or even elimination of drugs such as penicillin and ampicillin from available antibiotic choices for treating common infections in obstetrics and gynecology.",False,"Is the triple 'Ampicillin treats Infection' supported by the sentence: 'Penicillin Allergy in Pregnancy: Moving From ""Rash"" Decisions to Accurate Diagnosis.The emergence of beta-lactam-resistant pathogenic organisms has resulted in limitation or even elimination of drugs such as penicillin and ampicillin from available antibiotic choices for treating common infections in obstetrics and gynecology.'?","No, the statement ""Ampicillin treats Infection"" does not receive indirect support from the provided excerpt. In fact, it suggests quite the contrary. The passage mentions that due to the emergence of beta-lactam-resistant pathogenic organisms, drugs like penicillin and ampicillin have become limited or eliminated as antibiotic choices for common infections in obstetrics and gynecology. This implies that these drugs may no longer be as effective in treating infections, rather than supporting their efficacy." -16205290,Ampicillin treats chorioamnionitis,1430,"The patient was treated with pressors and antibiotics and was admitted to the medical intensive care unit where she received ampicillin, gentamycin, and clindamycin for suspected chorioamnionitis.",True,"Is the triple 'Ampicillin treats chorioamnionitis' supported by the sentence: 'The patient was treated with pressors and antibiotics and was admitted to the medical intensive care unit where she received ampicillin, gentamycin, and clindamycin for suspected chorioamnionitis.'?","Yes, the statement does provide indirect support for the phrase ""Ampicillin treats chorioamnionitis."" The patient in question was diagnosed with suspected chorioamnionitis and was treated with ampicillin as part of a broader antibiotic regimen in the intensive care unit (ICU). This suggests that ampicillin is used in treating chorioamnionitis since it was administered as part of the treatment for that specific condition in this case. However, it is important to note that chorioamnionitis can be caused by various microorganisms, so ampicillin might not be effective against all causative agents. Moreover, it was used in combination with gentamycin and clindamycin, which might indicate that ampicillin alone may not be sufficient for treating chorioamnionitis in some cases. Nonetheless, there is an association between ampicillin usage and chorioamnionitis treatment in this scenario." -15830384,Ampicillin treats bacterial infectious disease,1431,Based on these results aztreonam appears to be at least as effective as and possibly more effective than amikacin when used initially with ampicillin for empiric treatment of neonatal bacterial infections.,True,Is the triple 'Ampicillin treats bacterial infectious disease' supported by the sentence: 'Based on these results aztreonam appears to be at least as effective as and possibly more effective than amikacin when used initially with ampicillin for empiric treatment of neonatal bacterial infections.'?,"Yes, the statement does provide indirect support for the phrase ""Ampicillin treats bacterial infectious disease"". The statement suggests that ampicillin is used in combination with other antibiotics (aztreonam in this case) for empiric treatment of neonatal bacterial infections. This implies that ampicillin has antibacterial properties and is therefore used to treat bacterial infections. However, it should be noted that the statement does not directly prove that ampicillin treats bacterial infections as it is presented in the context of combination therapy." -14976711,Ampicillin treats osteomyelitis,1432,"When antibiotic therapy was delayed for seven days, osteomyelitis developed in four of eight animals treated locally with microencapsulated ampicillin and in six of eight animals that received parenteral ampicillin therapy.",True,"Is the triple 'Ampicillin treats osteomyelitis' supported by the sentence: 'When antibiotic therapy was delayed for seven days, osteomyelitis developed in four of eight animals treated locally with microencapsulated ampicillin and in six of eight animals that received parenteral ampicillin therapy.'?","Yes, indirect support can be inferred from the statement provided. The development of osteomyelitis in animals treated locally with microencapsulated ampicillin and in animals that received parenteral ampicillin therapy suggests that ampicillin may not be completely effective in treating osteomyelitis in all cases when administered alone. However, it does not explicitly state that ampicillin treats osteomyelitis effectively when administered promptly or in combination with other treatments. Therefore, while there is some positive correlation between ampicillin use and reduced osteomyelitis incidence, further investigation is required for definitive conclusions about ampicillin as an osteomyelitis treatment." -12551965,Ampicillin treats Sepsis,1433,"In the present study, we validated the antagonism in combinations of VCM with other beta-lactams, i.e., flomoxef (FMOX), ampicillin (AMPC), azthreonam (AZT) and imipenem/cilastatin (IPM/CS), in systemic infections and pneumoniain in mice.",False,"Is the triple 'Ampicillin treats Sepsis' supported by the sentence: 'In the present study, we validated the antagonism in combinations of VCM with other beta-lactams, i.e., flomoxef (FMOX), ampicillin (AMPC), azthreonam (AZT) and imipenem/cilastatin (IPM/CS), in systemic infections and pneumoniain in mice.'?","No, the statement does not provide direct support for the claim that ""Ampicillin treats Sepsis"". The study mentioned in the statement tested various antibiotic combinations in mice models for systemic infections and pneumonia; however, it did not explicitly investigate their efficacy against sepsis. Therefore, while ampicillin may have antimicrobial properties that could potentially be useful in treating sepsis, we cannot infer from this statement alone that it is an effective treatment for sepsis. Further investigation would be required for such a conclusion." -9906170,Ampicillin treats bacterial meningitis,1434,"The mortality rate in this type of BM is still high among those treated with ampicillin or penicillin, and a decrease in the mortality rate was not observed when the reported cases in Spain in the last 30 years were analyzed.",False,"Is the triple 'Ampicillin treats bacterial meningitis' supported by the sentence: 'The mortality rate in this type of BM is still high among those treated with ampicillin or penicillin, and a decrease in the mortality rate was not observed when the reported cases in Spain in the last 30 years were analyzed.'?","No, the statement does not provide indirect support for the phrase ""Ampicillin treats bacterial meningitis"". In fact, it seems to suggest that ampicillin (and penicillin) may not be effective in treating bacterial meningitis (BM), as there is no observed decrease in mortality rate among those treated with these antibiotics over the past 30 years in Spain. This raises concerns about their efficacy against BM. However, it is important to consider additional evidence from clinical trials and other studies before making definitive conclusions about ampicillin's effectiveness in treating bacterial meningitis." -8394714,Ampicillin treats gonorrhea,1435,Ampicillin has assumed a prominent role in the treatment of gonorrhoea.,True,Is the triple 'Ampicillin treats gonorrhea' supported by the sentence: 'Ampicillin has assumed a prominent role in the treatment of gonorrhoea.'?,"Yes, the statement ""Ampicillin has assumed a prominent role in the treatment of gonorrhea"" does provide indirect support for the phrase ""Ampicillin treats gonorrhea."" This is because assuming a prominent role in treatment implies that the drug is effective against the condition, which is gonorrhea in this case. However, it is important to note that ""treats"" is a general term that doesn't specify the degree or extent of effectiveness. Therefore, while there is support for ampicillin having some level of efficacy in treating gonorrhea, the statement doesn't necessarily imply that ampicillin is the most effective treatment available or that it works in all cases." -7166712,Ampicillin treats pneumonia,1436,[Clinical efficacy of sulbactam/ampicillin in comparison with cefotiam in the treatment of elderly patients with pneumonia].,True,Is the triple 'Ampicillin treats pneumonia' supported by the sentence: '[Clinical efficacy of sulbactam/ampicillin in comparison with cefotiam in the treatment of elderly patients with pneumonia].'?,"Yes, indirectly it does lend support. The title suggests that ampicillin is being used in combination with sulbactam for treating pneumonia in elderly patients. The fact that such a study was conducted implies that there is some basis for believing that ampicillin could be an effective treatment for pneumonia. However, it doesn't directly prove that ampicillin alone treats pneumonia because in this study it is used in combination with sulbactam. Therefore, further research would be needed to confirm whether ampicillin alone is effective against pneumonia." -22520021,Carbenicillin treats bacterial infectious disease,1437,In this study results of treatment with ceftazidime were superior to results of treatment with amikacin/carbenicillin for invasive bacterial infections of newborn infants.,True,Is the triple 'Carbenicillin treats bacterial infectious disease' supported by the sentence: 'In this study results of treatment with ceftazidime were superior to results of treatment with amikacin/carbenicillin for invasive bacterial infections of newborn infants.'?,"Yes, indirectly it does support that Carbenicillin can treat bacterial infectious disease in newborn infants when used in combination therapy with amikacin. The statement suggests that ceftazidime was more effective than amikacin/carbenicillin in treating invasive bacterial infections in newborn infants; however, it still implies that carbenicillin has some efficacy against bacterial infections in newborn infants when used in combination therapy. The fact that carbenicillin was used in a clinical trial for treating bacterial infections in newborn infants suggests that it is considered as a potential treatment option for bacterial infectious diseases in that population. - - That being said, it is important to note that carbenicillin is not always considered a first-line treatment for bacterial infections due to its narrower spectrum compared to some other antibiotics like ceftazidime. Moreover, adverse effects such as allergic reactions should be taken into account when prescribing carbenicillin. The combination therapy using carbenicillin may have its own set of benefits and drawbacks that need careful evaluation in specific clinical" -26119472,Bacampicillin treats bacterial infectious disease,1438,Clinical trial of bacampicillin in acute bacterial infections.,True,Is the triple 'Bacampicillin treats bacterial infectious disease' supported by the sentence: 'Clinical trial of bacampicillin in acute bacterial infections.'?,"Yes, the statement ""Clinical trial of bacampicillin in acute bacterial infections"" does provide indirect support for the claim that ""Bacampicillin treats bacterial infectious disease."" This is because conducting a clinical trial on bacampicillin specifically for acute bacterial infections suggests that there is an underlying assumption that bacampicillin has some therapeutic effect on bacterial infections. However, it is important to note that direct evidence from the statement is lacking; it does not explicitly state that bacampicillin treats bacterial infectious disease. To confirm this claim fully, one would need access to more specific information from the clinical trial such as its results and conclusions regarding bacampicillin's efficacy in treating bacterial infections." -25659721,Aspoxicillin treats bacterial infectious disease,1439,The above results suggest that ASPC is an useful antibiotic for treating pediatric bacterial infections.,True,Is the triple 'Aspoxicillin treats bacterial infectious disease' supported by the sentence: 'The above results suggest that ASPC is an useful antibiotic for treating pediatric bacterial infections.'?,"Yes, the statement ""The above results suggest that ASPC is an useful antibiotic for treating pediatric bacterial infections"" does provide indirect support for the phrase ""Aspoxicillin treats bacterial infectious disease."" This is because Aspoxicillin (ASPC) is a type of antibiotic, which is defined as a substance that inhibits the growth of bacteria. Therefore, if ASPC is found to be useful in treating pediatric bacterial infections, it implies that Aspoxicillin has antibacterial properties that allow it to treat bacterial infectious diseases in general, not only in pediatric patients but also in other populations. However, it is important to note that direct evidence from clinical trials or experiments specifically demonstrating Aspoxicillin's effectiveness against bacterial infections would provide stronger support for the claim that Aspoxicillin treats bacterial infectious disease." -13845936,Mezlocillin treats bacterial infectious disease,1440,"An open, multicentre study was performed in hospital in-patients at a total of 12 German hospitals to investigate the efficacy and tolerability of sulbactam combined with mezlocillin, piperacillin or cefotaxime in severe bacterial infections.",True,"Is the triple 'Mezlocillin treats bacterial infectious disease' supported by the sentence: 'An open, multicentre study was performed in hospital in-patients at a total of 12 German hospitals to investigate the efficacy and tolerability of sulbactam combined with mezlocillin, piperacillin or cefotaxime in severe bacterial infections.'?","Yes, indirectly it does support the claim that mezlocillin treats bacterial infectious disease. The statement mentions an open, multicentre study conducted in German hospitals investigating the efficacy and tolerability of sulbactam combined with mezlocillin in treating severe bacterial infections. The fact that mezlocillin is being studied in combination with sulbactam for treating severe bacterial infections suggests that mezlocillin has antibacterial properties that could potentially be useful for treating bacterial infectious diseases. However, it is important to note that more direct evidence would be needed before making a definitive conclusion about mezlocillin's effectiveness in treating bacterial infections, such as clinical trial results demonstrating its efficacy compared to placebo or alternative treatments." -7407212,Benzoyl Peroxide treats acne,1441,"Treatments for acne can be topical or systemic, and include retinoids, antibiotics, benzoyl peroxide, azelaic acid, and hormonal therapy.",True,"Is the triple 'Benzoyl Peroxide treats acne' supported by the sentence: 'Treatments for acne can be topical or systemic, and include retinoids, antibiotics, benzoyl peroxide, azelaic acid, and hormonal therapy.'?","Yes, the phrase ""Benzoyl Peroxide treats acne"" does receive indirect support from the statement: ""Treatments for acne can be topical or systemic, and include retinoids, antibiotics, benzoyl peroxide, azelaic acid, and hormonal therapy."" - - The statement lists Benzoyl Peroxide as one of the treatments for acne, which implies that it has been found to be effective in treating acne. Therefore, it lends credence to the claim that Benzoyl Peroxide treats acne. However, it is important to note that this is indirect support because the original statement does not explicitly state that Benzoyl Peroxide treats acne, but rather includes it in a list of treatments." -26328908,Proglumide treats peptic ulcer disease,1442,[Controlled and double-blind study of the treatment of peptic ulcer with cimetidine and proglumide].,True,Is the triple 'Proglumide treats peptic ulcer disease' supported by the sentence: '[Controlled and double-blind study of the treatment of peptic ulcer with cimetidine and proglumide].'?,"Yes, indirect support can be inferred from the statement. The fact that a controlled and double-blind study was conducted on the treatment of peptic ulcer using both cimetidine and proglumide implies that there is some scientific interest in investigating proglumide as a potential treatment for peptic ulcer disease. However, it does not provide direct evidence that proglumide alone treats peptic ulcer disease since the study involved comparing it against another treatment (cimetidine). To establish more robust support for proglumide as an effective treatment for peptic ulcer disease, further investigation would be required through additional studies specifically focusing on proglumide monotherapy, its efficacy compared to placebo, as well as its safety profile in treating peptic ulcers." -13022426,Pirenzepine treats gastroesophageal reflux disease,1443,Pirenzepine may provide a unique alternative for some GERD patients who may be refractory to other therapies of GERD.,True,Is the triple 'Pirenzepine treats gastroesophageal reflux disease' supported by the sentence: 'Pirenzepine may provide a unique alternative for some GERD patients who may be refractory to other therapies of GERD.'?,"Yes, the statement ""Pirenzepine may provide a unique alternative for some GERD patients who may be refractory to other therapies of GERD"" does lend indirect support to the claim that ""Pirenzepine treats gastroesophageal reflux disease (GERD)"". The key phrase here is ""treats gastroesophageal reflux disease"", which can be interpreted as an effective therapy for managing GERD symptoms. - - The statement suggests that Pirenzepine may be beneficial for certain GERD patients who have not responded well to other treatments. This implies that Pirenzepine has some efficacy in treating GERD symptoms, even if it is not the first-line treatment for all patients. Therefore, it does provide indirect support for the claim that Pirenzepine can treat GERD. However, it is essential to note that this does not constitute direct evidence; further investigation would be necessary to confirm Pirenzepine's effectiveness as a GERD treatment fully." -10839963,Pirenzepine treats peptic ulcer disease,1444,Four hundred and two patients with peptic ulcer were selected for acute therapy with either pirenzepine (100 mg/day) or cimetidine (800 mg/day) using the envelope method.,False,Is the triple 'Pirenzepine treats peptic ulcer disease' supported by the sentence: 'Four hundred and two patients with peptic ulcer were selected for acute therapy with either pirenzepine (100 mg/day) or cimetidine (800 mg/day) using the envelope method.'?,"No, the statement does not provide direct or indirect support for the claim that ""Pirenzepine treats peptic ulcer disease."" The statement only mentions that 402 patients were selected for acute therapy using either pirenzepine or cimetidine, but it does not provide any information about the outcomes of these treatments or whether pirenzepine was found to be effective in treating peptic ulcer disease specifically. Therefore, based on this statement alone, we cannot infer that pirenzepine is an effective treatment for peptic ulcer disease." -16332442,Magnesium Oxide treats autosomal recessive inherited pseudoxanthoma elasticum,1445,"In that context, magnesium oxide significantly reduced CIMT in PXE mice, and may be useful for disease prevention in PXE patients.",False,"Is the triple 'Magnesium Oxide treats autosomal recessive inherited pseudoxanthoma elasticum' supported by the sentence: 'In that context, magnesium oxide significantly reduced CIMT in PXE mice, and may be useful for disease prevention in PXE patients.'?","No, the phrase ""Magnesium Oxide treats autosomal recessive inherited pseudoxanthoma elasticum (PXE)"" does not receive indirect support from the statement: ""In that context, magnesium oxide significantly reduced CIMT in PXE mice, and may be useful for disease prevention in PXE patients."" - - The statement suggests that magnesium oxide may help reduce CIMT (carotid intima-media thickness) in PXE mice, which could potentially be useful for preventing disease progression in PXE patients. However, it does not explicitly mention that magnesium oxide treats autosomal recessive inherited pseudoxanthoma elasticum (PXE) itself; it only implies that it might help manage some symptoms (CIMT reduction) associated with PXE in mice models. - - Moreover, even though there is a correlation between magnesium oxide supplementation and reduced CIMT in PXE mice, it does not necessarily mean that magnesium oxide can treat PXE in humans because: - - 1) The study was conducted on mice (animal models" -15225864,Magnesium Oxide treats constipation disorder,1446,"This report presents the rare case of a 75-year-old woman who developed a rectal obstruction caused by a pharmacobezoar, following the long-term ingestion of magnesium oxide cathartics for constipation.",True,"Is the triple 'Magnesium Oxide treats constipation disorder' supported by the sentence: 'This report presents the rare case of a 75-year-old woman who developed a rectal obstruction caused by a pharmacobezoar, following the long-term ingestion of magnesium oxide cathartics for constipation.'?","Yes, indirectly it does lend some support. The statement provides evidence that magnesium oxide was used over an extended period as a cathartic (a medication that stimulates bowel movements) for treating constipation in a 75-year-old woman. The woman subsequently developed a rectal obstruction due to a pharmacobezoar (a mass formed by undigested medication). While magnesium oxide did not prevent constipation in this case, it still played a direct role in managing constipation symptoms, albeit unsuccessfully in the long term due to the development of complications. - - However, it is important to note that this single case report does not necessarily constitute definitive evidence for the general efficacy of magnesium oxide in treating constipation disorder due to several factors including individual variation in response to medication, potential confounding factors in the case report itself, as well as limitations in sample size. Further studies would be required to establish more robust evidence for its efficacy in treating constipation disorder." -26045826,Ticarcillin treats Sepsis,1447,Mezlocillin and ticarcillin in the treatment of patients with serious systemic infections.,True,Is the triple 'Ticarcillin treats Sepsis' supported by the sentence: 'Mezlocillin and ticarcillin in the treatment of patients with serious systemic infections.'?,"Yes, indirectly it does lend some support. The statement ""Mezlocillin and ticarcillin in the treatment of patients with serious systemic infections"" suggests that both Mezlocillin and Ticarcillin are used in treating severe systemic infections, which can include Sepsis. However, it doesn't specifically mention Sepsis as a condition treated by Ticarcillin. Therefore, while not direct, there is an implication that Ticarcillin could be used in treating Sepsis as part of treating severe systemic infections. But remember, this is an indirect inference based on a broader claim about systemic infections, not a direct claim about Sepsis treatment." -9410149,Ticarcillin treats osteomyelitis,1448,Obviously unbalanced comparative studies showed some benefit of ticarcillin for bone infections caused by Pseudomonas species.,True,Is the triple 'Ticarcillin treats osteomyelitis' supported by the sentence: 'Obviously unbalanced comparative studies showed some benefit of ticarcillin for bone infections caused by Pseudomonas species.'?,"Yes, the statement ""Obviously unbalanced comparative studies showed some benefit of ticarcillin for bone infections caused by Pseudomonas species"" does provide indirect support for the claim that ""Ticarcillin treats osteomyelitis."" The key term here is ""bone infections caused by Pseudomonas species,"" which is a specific type of osteomyelitis. Ticarcillin is an antibiotic that has been shown in unbalanced comparative studies (though these studies have limitations) to provide some benefit in treating these specific types of bone infections. However, it is important to note that this does not necessarily mean that ticarcillin is effective for all types of osteomyelitis, as its efficacy appears to be limited to infections caused by Pseudomonas species. Additionally, further research is needed to confirm these findings in more rigorous, balanced studies before definitive conclusions can be drawn about ticarcillin's effectiveness in treating osteomyelitis caused by Pseudomonas species." -26823243,Urea treats citrullinemia,1449,"The precursors of urea (ammonia, glutamate, glutamine and alpha-amino nitrogen) did not increase after the benzoate administration in the 6 normal subjects as well as in the 2 patients with citrullinaemia.",False,"Is the triple 'Urea treats citrullinemia' supported by the sentence: 'The precursors of urea (ammonia, glutamate, glutamine and alpha-amino nitrogen) did not increase after the benzoate administration in the 6 normal subjects as well as in the 2 patients with citrullinaemia.'?","No, the phrase ""Urea treats citrullinemia"" does not receive indirect support from the statement provided. The statement discusses the levels of certain precursors (ammonia, glutamate, glutamine, and alpha-amino nitrogen) in normal subjects and patients with citrullinemia after benzoate administration. It does not mention urea or its effects on citrullinemia. Indirect support would require connecting the concept of urea treatment for citrullinemia through related concepts or processes mentioned in the statement, but in this case, there is no such connection." -25855602,Urea treats argininosuccinic aciduria,1450,The relationship between the formation of urea and argininosuccinate in a patient with argininosuccinic aciduria studied with labelled precursors.,False,Is the triple 'Urea treats argininosuccinic aciduria' supported by the sentence: 'The relationship between the formation of urea and argininosuccinate in a patient with argininosuccinic aciduria studied with labelled precursors.'?,"No, the phrase ""Urea treats argininosuccinic aciduria"" does not receive direct support from the statement: ""The relationship between the formation of urea and argininosuccinate in a patient with argininosuccinic aciduria studied with labelled precursors."" - - The statement discusses a study involving labelled precursors in a patient with argininosuccinic aciduria, focusing on the formation of urea and argininosuccinate. However, it does not provide any information about urea as a treatment for argininosuccinic aciduria. - - Argininosuccinic aciduria is a genetic disorder characterized by an inability to break down argininosuccinic acid due to a deficiency in argininosuccinate lyase. Treatment typically involves dietary restrictions and supplementation with nitrogen-scavenging drugs that help remove excess nitrogen from the body, such as sodium phenylacetate and sodium benzoate. Urea itself is not typically used as a treatment because it cannot cross cell membranes and therefore cannot enter cells where it is needed to help remove ammonia." -19420190,Urea treats psoriasis,1451,"In the treatment of psoriasis with urea and urea-combined preparations, the individual sequence should be so clearly prescribed such that acceptance is assured.",False,"Is the triple 'Urea treats psoriasis' supported by the sentence: 'In the treatment of psoriasis with urea and urea-combined preparations, the individual sequence should be so clearly prescribed such that acceptance is assured.'?","No, the statement does not provide direct or indirect support for the claim that ""urea treats psoriasis"". The statement only suggests that there is a specific sequence in which urea-based treatments should be administered for psoriasis patients to ensure acceptance (presumably referring to patient compliance). It does not imply that urea itself is an active ingredient in treating psoriasis. Additional evidence would be required to establish a causal relationship between urea and improvements in psoriasis symptoms." -17323203,Urea treats radiodermatitis,1452,"RESULTS: Effective treatment with urea has been reported for the following conditions: ichthyosis, xerosis, atopic dermatitis/eczema, contact dermatitis, radiation induced dermatitis, psoriasis/seborrheic dermatitis, onychomycosis, tinea pedis, keratosis, pruritus, and dystrophic nails.",True,"Is the triple 'Urea treats radiodermatitis' supported by the sentence: 'RESULTS: Effective treatment with urea has been reported for the following conditions: ichthyosis, xerosis, atopic dermatitis/eczema, contact dermatitis, radiation induced dermatitis, psoriasis/seborrheic dermatitis, onychomycosis, tinea pedis, keratosis, pruritus, and dystrophic nails.'?","Yes, the phrase ""Urea treats radiodermatitis"" does receive indirect support from the statement provided. The statement lists ""radiation induced dermatitis"" as one of the conditions that urea has been reported as an effective treatment for. Radiodermatitis is a type of skin damage caused by radiation therapy, often observed in cancer patients. Therefore, it can be inferred that urea may indeed be beneficial in treating radiodermatitis. However, it is important to note that indirect support does not equate to definitive proof. Further research would be needed to confirm these findings and establish optimal treatment protocols." -15413374,Urea treats hepatocellular carcinoma,1453,"INTRODUCTION: Sorafenib is a novel oral bis-aryl urea compound that has proven survival benefit in patients with advanced hepatocellular carcinoma (HCC), for which several therapies are currently available with unsatisfactory results.",False,"Is the triple 'Urea treats hepatocellular carcinoma' supported by the sentence: 'INTRODUCTION: Sorafenib is a novel oral bis-aryl urea compound that has proven survival benefit in patients with advanced hepatocellular carcinoma (HCC), for which several therapies are currently available with unsatisfactory results.'?","No, the statement does not provide indirect support for the claim that ""urea treats hepatocellular carcinoma."" The statement introduces sorafenib as an oral bis-aryl urea compound that has survival benefits in patients with advanced hepatocellular carcinoma (HCC). Bis-aryl urea is different from urea; hence, it does not imply that urea itself has any therapeutic effects on HCC. This misconception may arise from confusing urea (NH2CONH2) with bis-aryl urea (a derivative), but they have different chemical properties that likely contribute to sorafenib's mechanism in treating HCC rather than urea itself being an effective treatment for HCC." -12068406,Urea treats type 2 diabetes mellitus,1454,These findings are consistent with the inhibition of hepatic glycogenolysis and support the use of acyl ureas for the treatment of type 2 diabetes.,False,Is the triple 'Urea treats type 2 diabetes mellitus' supported by the sentence: 'These findings are consistent with the inhibition of hepatic glycogenolysis and support the use of acyl ureas for the treatment of type 2 diabetes.'?,"No, the statement does not provide indirect support for the claim that ""urea treats type 2 diabetes mellitus."" The given statement refers specifically to ""acyl ureas,"" not urea itself. Urea is a simple organic compound containing nitrogen that is excreted by urine; it is different from acyl ureas which contain an acyl group (a functional group consisting of a carbon atom double-bonded to an oxygen atom: C=O). Therefore, one cannot infer that urea has therapeutic potential for type 2 diabetes mellitus based on evidence supporting acyl ureas as potential therapeutic agents for diabetes management." -11649881,Urea treats Pain,1455,"Novel transient receptor potential vanilloid 1 receptor antagonists for the treatment of pain: structure-activity relationships for ureas with quinoline, isoquinoline, quinazoline, phthalazine, quinoxaline, and cinnoline moieties.",True,"Is the triple 'Urea treats Pain' supported by the sentence: 'Novel transient receptor potential vanilloid 1 receptor antagonists for the treatment of pain: structure-activity relationships for ureas with quinoline, isoquinoline, quinazoline, phthalazine, quinoxaline, and cinnoline moieties.'?","Yes, indirectly it does. The statement provides evidence that ureas have been investigated for their potential as transient receptor potential vanilloid 1 (TRPV1) receptor antagonists, which are known to play a role in pain perception. Therefore, if urea compounds can effectively antagonize TRPV1 receptors, they may indeed have an impact on pain treatment. However, it is important to note that this statement does not explicitly demonstrate that urea itself treats pain; rather, it suggests that certain urea-based compounds might have potential as pain treatments. Further investigation and clinical trials would be necessary to confirm such a claim." -10679439,Urea treats skin disorder,1456,[TROPHIC ACTION OF UREA AND ITS USE IN THE TREATMENT OF NEUROTROPHIC SKIN DISEASES].,True,Is the triple 'Urea treats skin disorder' supported by the sentence: '[TROPHIC ACTION OF UREA AND ITS USE IN THE TREATMENT OF NEUROTROPHIC SKIN DISEASES].'?,"Yes, the phrase ""Urea treats skin disorder"" does receive indirect support from the statement: ""[TROPHIC ACTION OF UREA AND ITS USE IN THE TREATMENT OF NEUROTROPHIC SKIN DISEASES]."" This is because neurotrophic skin diseases fall under the category of skin disorders. Urea's trophic action refers to its ability to improve the nutrition of skin cells, which can be beneficial in managing various skin conditions. However, it is crucial to note that such support is indirect; the statement does not explicitly confirm that urea treats all skin disorders but rather implies its potential therapeutic effect on neurotrophic skin diseases specifically." -10511987,Urea treats diabetes mellitus,1457,"[Preliminary note on the oral treatment of diabetes by N-sulfonyl-p-methylbenzene-N'-n-butyl urea or D 860, a product free of antibacterial action].",False,"Is the triple 'Urea treats diabetes mellitus' supported by the sentence: '[Preliminary note on the oral treatment of diabetes by N-sulfonyl-p-methylbenzene-N'-n-butyl urea or D 860, a product free of antibacterial action].'?","No, the statement does not provide indirect support for the claim that urea treats diabetes mellitus. The statement discusses the oral treatment of diabetes using N-sulfonyl-p-methylbenzene-N'-n-butyl urea (D 860), which is a specific chemical compound different from urea. Urea is a waste product that is not known to have any direct effects on diabetes management. Therefore, without further evidence connecting urea to diabetes treatment, it is incorrect to assume that urea can treat diabetes based on this statement about D 860." -8678587,"Urea treats dermatitis, atopic",1458,"In the present report, we compared two creams, identical with the exception that one contained both urea and sodium chloride and the other urea alone, in 22 patients with atopic dermatitis.",True,"Is the triple 'Urea treats dermatitis, atopic' supported by the sentence: 'In the present report, we compared two creams, identical with the exception that one contained both urea and sodium chloride and the other urea alone, in 22 patients with atopic dermatitis.'?","Yes, the statement does provide indirect support for the phrase ""Urea treats dermatitis, atopic"". This is because it mentions a study where two creams were compared, one containing urea alone and the other containing both urea and sodium chloride, in patients with atopic dermatitis. The fact that such a study was conducted suggests that there is some biological plausibility or existing knowledge suggesting urea could have therapeutic effects on atopic dermatitis. However, it is important to note that this study does not necessarily prove that urea alone treats atopic dermatitis, as it does not mention the results of the study or whether there were any significant differences between the two creams. Further investigation would be required to confirm whether urea does indeed have a positive effect on atopic dermatitis." -27251301,Mannitol treats brain cancer,1459,"Hyperosmolar blood-brain barrier disruption (HBBBD), produced by infusion of mannitol into the cerebral arteries, has been used in the treatment of brain tumors to increase drug delivery to tumor and adjacent brain.",True,"Is the triple 'Mannitol treats brain cancer' supported by the sentence: 'Hyperosmolar blood-brain barrier disruption (HBBBD), produced by infusion of mannitol into the cerebral arteries, has been used in the treatment of brain tumors to increase drug delivery to tumor and adjacent brain.'?","Yes, indirectly it does support the statement that mannitol can be used in treating brain cancer. The provided evidence suggests that mannitol has been used in hyperosmolar blood-brain barrier disruption (HBBBD) for increasing drug delivery to brain tumors and adjacent brain tissue. This implies that mannitol may play an essential role in brain cancer treatment by facilitating better penetration of therapeutic agents into tumor sites. However, it does not necessarily mean that mannitol itself is treating brain cancer but rather that it is enhancing treatment effectiveness when used in combination with other drugs." -21059003,Mannitol treats hearing loss disorder,1460,[Effects of mannitol on the fluids of the internal ear. Use in the treatment of deafness].,True,Is the triple 'Mannitol treats hearing loss disorder' supported by the sentence: '[Effects of mannitol on the fluids of the internal ear. Use in the treatment of deafness].'?,"Yes, the statement ""Effects of mannitol on the fluids of the internal ear. Use in the treatment of deafness"" does provide indirect support for the phrase ""Mannitol treats hearing loss disorder."" Mannitol is mentioned as having an effect on the fluids within the inner ear, which is directly related to hearing function. Additionally, its use is described in treating deafness (or hearing loss disorder). + The conclusion is about a study comparing the effectiveness of prednisolone versus itraconazole in treating acute-stage allergic bronchopulmonary aspergillosis (ABPA). It does not mention ibuprofen or osteoarthritis at all. Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) commonly used for pain relief, while osteoarthritis is a degenerative joint disease. Therefore, there is no connection between the two statements." +8106985,Ibuprofen related to burn,120,"Purpose: The aim of this study was to compare asparaginase-related toxicities in two asparaginase preparations, namely native Escherichia coli L-asparaginase (L-ASP) and pegylated asparaginase (PEG-ASP) in combination with ifosfamide, methotrexate, etoposide, and prednisolone (IMEP) in natural killer (NK)/T-cell lymphoma (NTCL).",False,"'Does the phrase ""Ibuprofen related to burn"" receive at least indirect support from the statement: ""Purpose: The aim of this study was to compare asparaginase-related toxicities in two asparaginase preparations, namely native Escherichia coli L-asparaginase (L-ASP) and pegylated asparaginase (PEG-ASP) in combination with ifosfamide, methotrexate, etoposide, and prednisolone (IMEP) in natural killer (NK)/T-cell lymphoma (NTCL).""?","No, the statement does not provide indirect support for the phrase ""Ibuprofen related to burn"". The purpose of the study mentioned in the statement is focused on comparing asparaginase-related toxicities in two asparaginase preparations when used in combination with specific chemotherapy agents for treating natural killer (NK)/T-cell lymphoma (NTCL). Ibuprofen is not mentioned in the statement, nor is there any connection made between ibuprofen use and burns. Therefore, there is no implied or indirect relationship between ibuprofen use and burns in this context." +13726345,Ibuprofen causes patent ductus arteriosus,121,Prednisolone combined with adjunctive immunosuppression is not superior to prednisolone alone in terms of efficacy and safety in giant cell arteritis: meta-analysis.,False,"'Does the phrase ""Ibuprofen causes patent ductus arteriosus"" receive at least indirect support from the statement: ""Prednisolone combined with adjunctive immunosuppression is not superior to prednisolone alone in terms of efficacy and safety in giant cell arteritis: meta-analysis.""?","No, the statement does not provide indirect support for the phrase ""Ibuprofen causes patent ductus arteriosus."" The meta-analysis focuses on comparing the efficacy and safety of prednisolone combined with adjunctive immunosuppression versus prednisolone alone in treating giant cell arteritis. Ibuprofen is not mentioned in the statement, nor is there any reference made to patent ductus arteriosus (PDA), which is a congenital heart defect unrelated to giant cell arteritis or treatments for it. - + Patent ductus arteriosus is caused by incomplete closure of the ductus arteriosus after birth, which is influenced by various genetic and environmental factors; it is not known to be linked to ibuprofen use in any direct way. While ibuprofen is part of a class of nonsteroidal anti-inflammatory drugs (NSAIDs) that can affect platelet function and potentially contribute to cardiovascular issues in some contexts, there is no evidence supporting its direct causation of PDA in newborns or any population. - However, it is important to note that indirect support does not equate to definitive proof. Further investigation would be necessary to establish if mannitol effectively treats hearing loss disorders in various contexts, as well as any possible side effects, contraindications, optimal dosages, or therapeutic ranges that should be considered when employing mannitol for treating hearing loss disorders." -20425957,Mannitol treats osteoarthritis,1461,Objective: To assess efficacy and safety of a single intra-articular injection of 2% sodium hyaluronate plus 0.5% mannitol in patients with symptomatic osteoarthritis of the knee.,True,Is the triple 'Mannitol treats osteoarthritis' supported by the sentence: 'Objective: To assess efficacy and safety of a single intra-articular injection of 2% sodium hyaluronate plus 0.5% mannitol in patients with symptomatic osteoarthritis of the knee.'?,"Yes, indirectly it does support the claim that mannitol may have beneficial effects in treating osteoarthritis when used in conjunction with sodium hyaluronate. The statement mentions an objective to assess the efficacy and safety of a single intra-articular injection containing both 2% sodium hyaluronate and 0.5% mannitol in patients with symptomatic osteoarthritis of the knee. + In summary, as there is no" +13653982,Ibuprofen causes Alzheimer disease,122,CONCLUSION: GVP is well-tolerated regimen with high response rate and needs to be tested in late relapsed HL.,False,"'Does the phrase ""Ibuprofen causes Alzheimer disease"" receive at least indirect support from the statement: ""CONCLUSION: GVP is well-tolerated regimen with high response rate and needs to be tested in late relapsed HL.""?","No, the phrase ""Ibuprofen causes Alzheimer disease"" does not receive any direct or indirect support from the statement ""CONCLUSION: GVP is well-tolerated regimen with high response rate and needs to be tested in late relapsed HL."" - However, it is important to note that this statement does not explicitly confirm that mannitol alone treats osteoarthritis but rather implies that mannitol might have some therapeutic potential when combined with sodium hyaluronate in treating osteoarthritis symptoms. Further investigation would be necessary through clinical trials and studies specifically designed to evaluate mannitol's impact on osteoarthritis as a standalone treatment in order to confirm its direct efficacy in treating osteoarthritis." -16945033,Mannitol treats hypotensive disorder,1462,"These values were correlated with expected risk factors for lactatemia including length of surgery, Body Mass Index (BMI), hypotension, hemoglobin and mannitol therapy.",False,"Is the triple 'Mannitol treats hypotensive disorder' supported by the sentence: 'These values were correlated with expected risk factors for lactatemia including length of surgery, Body Mass Index (BMI), hypotension, hemoglobin and mannitol therapy.'?","No, the statement does not provide direct support for the claim that Mannitol treats hypotensive disorder. The passage mentions Mannitol therapy in association with hypotension as one of several risk factors for lactatemia (elevated levels of lactate in the blood). However, it does not indicate that Mannitol is used as a treatment for hypotension itself. The statement implies that hypotension is correlated with Mannitol therapy in terms of increased risk for lactatemia; it does not provide evidence that Mannitol is an effective treatment for hypotensive disorder." -12644644,Mannitol treats Pain,1463,"Further treatments with intravenous mannitol, oral carbonic anhydrase inhibitor, topical antiglaumatic agents and subconjunctival 5-fluorouracil (5-FU) injections all failed to control relapsing pain and IOP elevation.",False,"Is the triple 'Mannitol treats Pain' supported by the sentence: 'Further treatments with intravenous mannitol, oral carbonic anhydrase inhibitor, topical antiglaumatic agents and subconjunctival 5-fluorouracil (5-FU) injections all failed to control relapsing pain and IOP elevation.'?","No, the statement does not provide indirect support for the claim that ""Mannitol treats Pain"". In fact, it suggests quite the opposite: treatments including intravenous mannitol were ineffective in controlling pain and intraocular pressure (IOP) elevation. This implies that mannitol may not be an effective treatment for pain in this context. However, it is important to note that this does not definitively rule out mannitol as a potential pain treatment in other circumstances, as its efficacy could depend on various factors such as dosage, administration method, patient characteristics, and specific type/cause of pain. Nonetheless, based on the information provided in the statement, mannitol does not appear to be an effective pain treatment in this particular case." -11774217,Mannitol treats brain injury,1464,CONCLUSIONS: The results suggested that mannitol could improve cerebral perfusion in patients with mild brain damage.,True,Is the triple 'Mannitol treats brain injury' supported by the sentence: 'CONCLUSIONS: The results suggested that mannitol could improve cerebral perfusion in patients with mild brain damage.'?,"Yes, the statement ""CONCLUSIONS: The results suggested that mannitol could improve cerebral perfusion in patients with mild brain damage"" does provide indirect support for the claim that mannitol treats brain injury. The conclusion suggests that mannitol has therapeutic potential in improving cerebral perfusion in individuals who have experienced mild brain damage, which can be considered an aspect of treating brain injury as it addresses one of the consequences of such trauma. + The statement in question is related to a treatment regimen called GVP (Gemcitabine + Vinorelbine + Prednisone) in patients with late relapsed Hodgkin Lymphoma (HL). There is no mention of Ibuprofen nor any reference made to Alzheimer disease in the statement provided. Thus, it does not lend any support - direct or indirect - to the claim that Ibuprofen causes Alzheimer disease. - + To further clarify, Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) commonly used for its analgesic (pain-relieving) and antipyretic (fever-reducing) effects. Alzheimer disease is a neurodegenerative disorder characterized by memory loss, cognitive decline, and behavioral changes. While there have been some studies suggesting that chronic" +13133316,Ibuprofen causes peptic ulcer disease,123,Early treatment with addition of low dose prednisolone to methotrexate improves therapeutic outcome in severe psoriatic arthritis.,False,"'Does the phrase ""Ibuprofen causes peptic ulcer disease"" receive at least indirect support from the statement: ""Early treatment with addition of low dose prednisolone to methotrexate improves therapeutic outcome in severe psoriatic arthritis.""?","No, the statement ""Early treatment with addition of low dose prednisolone to methotrexate improves therapeutic outcome in severe psoriatic arthritis"" does not provide indirect support for the claim that ""Ibuprofen causes peptic ulcer disease."" - However, it is crucial to note that the evidence provided in this statement is limited in scope as it only addresses mild brain damage and cerebral perfusion improvement without exploring other potential benefits or risks associated with mannitol treatment for brain injuries. Therefore, further investigation is required before making definitive conclusions about mannitol as an effective treatment for various forms and severities of brain injuries." -11660589,Mannitol treats malaria,1465,"A possibly indulgent wish list of outcome (mortality) studies using currently known treatment modalities, however, includes the loading dose of quinine, vigorous fluid replacement, ET, the artemisinins, mannitol, and N-acetylcysteine in the treatment of severe malaria.",True,"Is the triple 'Mannitol treats malaria' supported by the sentence: 'A possibly indulgent wish list of outcome (mortality) studies using currently known treatment modalities, however, includes the loading dose of quinine, vigorous fluid replacement, ET, the artemisinins, mannitol, and N-acetylcysteine in the treatment of severe malaria.'?","Yes, while indirectly, the statement ""A possibly indulgent wish list of outcome (mortality) studies using currently known treatment modalities includes...mannitol...in the treatment of severe malaria"" does lend some support for the claim that mannitol treats malaria. + The two statements discuss different subjects and therapeutic interventions. The first statement refers to a treatment regimen for psoriatic arthritis involving methotrexate and low-dose prednisolone, while the second statement refers to ibuprofen causing peptic ulcer disease. - The statement suggests that mannitol is one of the treatments being considered in studies on severe malaria treatment modalities. The fact that mannitol is included in these studies implies that there is some rationale behind investigating its potential therapeutic benefits in treating malaria. + While ibuprofen is an NSAID (nonsteroidal anti-inflammatory drug) that can increase the risk of developing peptic ulcers as a side effect, especially when taken in high doses or over an extended period of time (Nikfar et al., 2002), it does not imply that ibuprofen is the sole cause of peptic ulcer disease. - However, it is important to note that being included in such studies does not necessarily equate to mannitol being an established treatment for malaria. Including mannitol in these studies simply means that there is interest in exploring its potential as a therapeutic option for treating severe malaria. Therefore, further investigation is required before making any definitive conclusions about mannitol as an effective treatment for malaria based on this statement alone." -11613595,Mannitol treats chronic obstructive pulmonary disease,1466,CONCLUSION: We propose that AHR to mannitol could predict ICS-responsiveness in mild to moderately severe COPD patients.,False,Is the triple 'Mannitol treats chronic obstructive pulmonary disease' supported by the sentence: 'CONCLUSION: We propose that AHR to mannitol could predict ICS-responsiveness in mild to moderately severe COPD patients.'?,"No, the phrase ""Mannitol treats chronic obstructive pulmonary disease"" does not receive indirect support from the statement: ""CONCLUSION: We propose that AHR to mannitol could predict ICS-responsiveness in mild to moderately severe COPD patients."" + The misconception may arise because ibuprofen is one of many factors that can contribute to peptic ulcer disease; however, it is not accurate to" +12641386,Ibuprofen causes Fever,124,"CONCLUSION: Flu/Cy/ATG conditioning regimen, bone marrow as stem cell source and CSA, prednisolone and short methotrexate regimen were associated with better survival in AA.",False,"'Does the phrase ""Ibuprofen causes Fever"" receive at least indirect support from the statement: ""CONCLUSION: Flu/Cy/ATG conditioning regimen, bone marrow as stem cell source and CSA, prednisolone and short methotrexate regimen were associated with better survival in AA.""?","No, the statement ""Ibuprofen causes Fever"" does not receive at least indirect support from the conclusion provided in the study about hematopoietic stem cell transplantation in acute myeloid leukemia (AML) patients. The conclusion mentions various factors associated with better survival in acute myeloid leukemia patients but does not make any reference to ibuprofen nor fever, making it irrelevant in supporting or contradicting the claim that ibuprofen causes fever. - The statement in question comes from a study investigating the potential for mannitol airway hyperresponsiveness (AHR) as a predictor for inhaled corticosteroid (ICS) responsiveness in chronic obstructive pulmonary disease (COPD) patients. The study does not claim that mannitol treats COPD; rather it suggests that mannitol AHR could be used as an indicator for ICS responsiveness in specific COPD patient populations (mild to moderately severe). + Ibuprofen is actually an antipyretic agent used for reducing fever; therefore, it is not likely that it would cause fever as suggested in your question. If there is any evidence linking ibuprofen use to fever, it would require separate investigation and cannot be inferred from the given study conclusion related to hematopoietic stem cell transplantation in AML patients." +12482174,Ibuprofen causes pancreatitis,125,Effect of addition of short course of prednisolone to gluten-free diet on mucosal epithelial cell regeneration and apoptosis in celiac disease: a pilot randomized controlled trial.,False,"'Does the phrase ""Ibuprofen causes pancreatitis"" receive at least indirect support from the statement: ""Effect of addition of short course of prednisolone to gluten-free diet on mucosal epithelial cell regeneration and apoptosis in celiac disease: a pilot randomized controlled trial.""?","No, the statement does not provide any indirect support for the phrase ""Ibuprofen causes pancreatitis."" The study mentioned is focused on the effects of adding a short course of prednisolone to a gluten-free diet on mucosal epithelial cell regeneration and apoptosis in celiac disease. It does not involve Ibuprofen or discuss its potential side effects or relationship to pancreatitis. Therefore, it does not contribute any evidence, direct or indirect, to the claim about Ibuprofen causing pancreatitis." +12438812,Ibuprofen causes Toothache,126,Coadministration of cyclosporin a with prednisolone in acute interstitial pneumonia complicating polymyositis/dermatomyositis.,False,"'Does the phrase ""Ibuprofen causes Toothache"" receive at least indirect support from the statement: ""Coadministration of cyclosporin a with prednisolone in acute interstitial pneumonia complicating polymyositis/dermatomyositis.""?","No, the phrase ""Ibuprofen causes Toothache"" does not receive any direct or indirect support from the statement ""Coadministration of cyclosporin a with prednisolone in acute interstitial pneumonia complicating polymyositis/dermatomyositis."" - The distinction here is crucial; while mannitol may potentially help in predicting which patients might respond better to ICS treatment (indirectly supporting better patient outcomes), it does not imply mannitol as a standalone treatment for COPD nor does it claim that mannitol has therapeutic effects on COPD symptoms." -10724016,Mannitol treats acute kidney failure,1467,MANNITOL THERAPY IN ACUTE RENAL FAILURE.,True,Is the triple 'Mannitol treats acute kidney failure' supported by the sentence: 'MANNITOL THERAPY IN ACUTE RENAL FAILURE.'?,"Yes, the statement ""MANNITOL THERAPY IN ACUTE RENAL FAILURE"" does provide indirect support for the phrase ""Mannitol treats acute kidney failure"". The term 'Mannitol Therapy' implies that Mannitol is being used as a treatment for something, in this case, it is specifically related to acute renal failure (also known as acute kidney failure). However, it is important to note that indirect support does not equate to definitive proof; further evidence would be required to confirm Mannitol's efficacy in treating acute kidney failure." -10707564,Mannitol treats injury,1468,Mannitol has a beneficial effect on ischemic injury following a short-duration forebrain ischemic insult in rats.,True,Is the triple 'Mannitol treats injury' supported by the sentence: 'Mannitol has a beneficial effect on ischemic injury following a short-duration forebrain ischemic insult in rats.'?,"Yes, the statement ""Mannitol has a beneficial effect on ischemic injury following a short-duration forebrain ischemic insult in rats"" does provide indirect support for the claim that ""Mannitol treats injury"". This is because ischemic injury is a type of injury that occurs when there is reduced blood flow to an organ or tissue, such as in the case of stroke or other conditions where blood supply is compromised. Mannitol has been shown in this study to have a beneficial effect on ischemic injury in rats following a short-duration forebrain ischemic insult. + The reason for this is that neither ibuprofen nor toothache is mentioned in the provided statement. Furthermore, there is no mechanistic link or plausible biological reasoning that could connect coadministration of cyclosporin a with prednisolone in acute interstitial pneumonia complicating polymyositis/dermatomyositis to ibuprofen causing toothache." +12079834,Ibuprofen causes adult acute respiratory distress syndrome,127,"Efficacy of immunoglobulin plus prednisolone for prevention of coronary artery abnormalities in severe Kawasaki disease (RAISE study): a randomised, open-label, blinded-endpoints trial.",False,"'Does the phrase ""Ibuprofen causes adult acute respiratory distress syndrome"" receive at least indirect support from the statement: ""Efficacy of immunoglobulin plus prednisolone for prevention of coronary artery abnormalities in severe Kawasaki disease (RAISE study): a randomised, open-label, blinded-endpoints trial.""?","No, the statement does not provide any indirect support for the phrase ""Ibuprofen causes adult acute respiratory distress syndrome."" The RAISE study is focused on evaluating the efficacy of immunoglobulin plus prednisolone for prevention of coronary artery abnormalities in severe Kawasaki disease. Ibuprofen is not mentioned in the study, nor is there any discussion of acute respiratory distress syndrome (ARDS) in adults or its potential causes. Therefore, there is no connection that can be drawn between these two statements based on the provided evidence." +11157616,Ibuprofen causes Pain,128,"Response of vincristine, melphalan, cyclophosphamide and prednisolone in refractory multiple myeloma.",False,"'Does the phrase ""Ibuprofen causes Pain"" receive at least indirect support from the statement: ""Response of vincristine, melphalan, cyclophosphamide and prednisolone in refractory multiple myeloma.""?","No, the statement ""Response of vincristine, melphalan, cyclophosphamide and prednisolone in refractory multiple myeloma"" does not provide indirect support for the phrase ""Ibuprofen causes Pain."" - However, it is important to note that while this finding does provide some evidence for mannitol as a potential treatment for injury in general, it does not necessarily mean that mannitol will be effective in all types of injuries or in human patients. The study was conducted in rats, not humans, and focused specifically on ischemic injury in the forebrain following short-duration insults. Additional studies would be needed to determine whether mannitol has similar effects in other injury models, species, and contexts before making any definitive conclusions about its therapeutic potential for treating injuries more broadly. + The statement in question is about the response of certain drugs (vincristine, melphalan, cyclophosphamide, and prednisolone) in treating refractory multiple myeloma, a type of cancer. Ibuprofen is not mentioned in this statement, nor is there any connection made between these drugs and pain cause or relief. Ibuprofen is an analgesic and anti-inflammatory drug commonly used for relieving pain, fever, and inflammation, which is unrelated to the context of the provided statement." +10429873,Ibuprofen causes Hemorrhage,129,Pyruvate kinase M2 and prednisolone resistance in acute lymphoblastic leukemia.,False,"'Does the phrase ""Ibuprofen causes Hemorrhage"" receive at least indirect support from the statement: ""Pyruvate kinase M2 and prednisolone resistance in acute lymphoblastic leukemia.""?","No, the phrase ""Ibuprofen causes Hemorrhage"" does not receive any direct or indirect support from the statement ""Pyruvate kinase M2 and prednisolone resistance in acute lymphoblastic leukemia."" - Furthermore" -9454905,Mannitol treats ciguatera fish poisoning,1469,IV mannitol is considered the treatment of choice for CP but has not been evaluated in a double-blind randomized trial.,True,Is the triple 'Mannitol treats ciguatera fish poisoning' supported by the sentence: 'IV mannitol is considered the treatment of choice for CP but has not been evaluated in a double-blind randomized trial.'?,"Yes, while the statement does not explicitly confirm that mannitol treats ciguatera fish poisoning (CP), it does suggest that intravenous (IV) mannitol is considered the treatment of choice for CP based on current knowledge and understanding. The absence of a double-blind randomized trial does not necessarily disprove its effectiveness; however, it does indicate that there is a lack of rigorous clinical evidence supporting its use as a definitive treatment for CP. Nonetheless, without direct evidence refuting mannitol's efficacy in treating CP, one could infer indirect support for the initial claim based on expert consensus and its widespread use in clinical settings. However, further rigorous evaluation is needed for more conclusive evidence regarding mannitol's effectiveness in treating ciguatera fish poisoning." -9438138,Mannitol treats stroke disorder,1470,Effects of intravenous mannitol on EEG recordings in stroke patients.,False,Is the triple 'Mannitol treats stroke disorder' supported by the sentence: 'Effects of intravenous mannitol on EEG recordings in stroke patients.'?,"No, the statement ""Effects of intravenous mannitol on EEG recordings in stroke patients"" does not provide direct or indirect support for the claim that ""Mannitol treats stroke disorder"". This is because the provided statement only discusses the effects of mannitol on EEG recordings in stroke patients, which is an electrophysiological response rather than a clinical benefit or treatment for stroke disorder. + The statement in question discusses two specific biological concepts related to acute lymphoblastic leukemia - pyruvate kinase M2 (PKM2) and prednisolone resistance. Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) used for pain relief and reducing inflammation, while hemorrhage refers to excessive bleeding. There is no mention of ibuprofen or its potential side effects in the provided statement; hence it does not offer any support for the claim that ibuprofen causes hemorrhage." +9800201,Ibuprofen causes arthritic joint disease,130,"Stimulation with prednisolone and TNFalpha reduced GDF-5 expression in OA and RA fibroblasts, whereas MTX and IL-1beta revealed minor or no relevant change.",False,"'Does the phrase ""Ibuprofen causes arthritic joint disease"" receive at least indirect support from the statement: ""Stimulation with prednisolone and TNFalpha reduced GDF-5 expression in OA and RA fibroblasts, whereas MTX and IL-1beta revealed minor or no relevant change.""?","No, the statement does not provide any indirect support for the phrase ""Ibuprofen causes arthritic joint disease."" The statement discusses the effects of various substances (prednisolone, TNFalpha, MTX, IL-1beta) on GDF-5 expression in osteoarthritis (OA) and rheumatoid arthritis (RA) fibroblasts, but it does not mention ibuprofen at all. Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) commonly used for pain relief and reducing inflammation, but it is not mentioned in the provided statement. Therefore, it is not possible to draw any conclusions about ibuprofen's effects on arthritic joint disease based on this statement alone." +8163776,Ibuprofen causes injury,131,"A combination of rituximab plus chemotherapy, rituximab+cyclophosphamide+doxorubicin+vincristine+prednisolone (R-CHOP), has the highest efficacy ever described with any chemotherapy in DLBCL and FL.",False,"'Does the phrase ""Ibuprofen causes injury"" receive at least indirect support from the statement: ""A combination of rituximab plus chemotherapy, rituximab+cyclophosphamide+doxorubicin+vincristine+prednisolone (R-CHOP), has the highest efficacy ever described with any chemotherapy in DLBCL and FL.""?","No, the statement does not provide indirect support for ""Ibuprofen causes injury."" The statement discusses the efficacy of a specific chemotherapy regimen (R-CHOP) in treating certain types of lymphoma (diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma (FL)). Ibuprofen is an over-the-counter nonsteroidal anti-inflammatory drug (NSAID) used for pain relief, fever reduction, and inflammation. There is no connection between these two statements in terms of causality or implications for injury." +26701175,Ibuprofen affects rheumatoid arthritis,132,"A combination of rituximab plus chemotherapy, rituximab+cyclophosphamide+doxorubicin+vincristine+prednisolone (R-CHOP), has the highest efficacy ever described with any chemotherapy in DLBCL and FL.",False,"'Does the phrase ""Ibuprofen affects rheumatoid arthritis"" receive at least indirect support from the statement: ""A combination of rituximab plus chemotherapy, rituximab+cyclophosphamide+doxorubicin+vincristine+prednisolone (R-CHOP), has the highest efficacy ever described with any chemotherapy in DLBCL and FL.""?","No, there is no direct or indirect support for the phrase ""Ibuprofen affects rheumatoid arthritis"" in the given statement about R-CHOP therapy for diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma (FL). The statement discusses the efficacy of R-CHOP therapy for specific types of lymphoma but does not mention ibuprofen or rheumatoid arthritis at all. Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) commonly used for pain relief and fever reduction, while rheumatoid arthritis is an autoimmune disorder that causes inflammation in joints; they do not have any direct relationship with R-CHOP therapy for lymphoma treatment." +24384432,Ibuprofen affects migraine disorder,133,Weekly docetaxel and prednisolone versus prednisolone alone in androgen-independent prostate cancer: a randomized phase II study.,False,"'Does the phrase ""Ibuprofen affects migraine disorder"" receive at least indirect support from the statement: ""Weekly docetaxel and prednisolone versus prednisolone alone in androgen-independent prostate cancer: a randomized phase II study.""?","No, the statement ""Weekly docetaxel and prednisolone versus prednisolone alone in androgen-independent prostate cancer: a randomized phase II study"" does not provide indirect support for the phrase ""Ibuprofen affects migraine disorder."" - In order for the statement to provide indirect support for treating stroke disorder, there should be some connection between mannitol affecting EEG recordings in stroke patients and an improvement in their condition. However, without additional information linking these two factors together, it is not possible to infer that mannitol has any therapeutic effect on stroke disorder based solely on its influence on EEG recordings. + The statement is a title of a study about treating prostate cancer with docetaxel and prednisolone, either alone or in combination. Ibuprofen is not mentioned in the title, nor does it have any clear connection to migraines or the treatment of prostate cancer. Therefore, there is no reasonable basis for inferring that this study provides any support for the claim about Ibuprofen's effect on migraines." +23500890,Ibuprofen affects adult acute respiratory distress syndrome,134,Prednisolone and azathioprine in membranous nephropathy: a 10-year follow-up study.,False,"'Does the phrase ""Ibuprofen affects adult acute respiratory distress syndrome"" receive at least indirect support from the statement: ""Prednisolone and azathioprine in membranous nephropathy: a 10-year follow-up study.""?","No, the statement ""Prednisolone and azathioprine in membranous nephropathy: a 10-year follow-up study"" does not provide indirect support for the phrase ""Ibuprofen affects adult acute respiratory distress syndrome."" The study in question focuses on the effects of prednisolone and azathioprine on membranous nephropathy over a 10-year period. Ibuprofen is not mentioned in the study, nor is there any discussion of acute respiratory distress syndrome (ARDS) or related conditions. Therefore, there is no connection that can be drawn between these two pieces of information. - Furthermore, it is important to note that even if mannitol does have an effect on EEG recordings in stroke patients, it does not automatically imply that mannitol is treating stroke disorder; there could be other explanations for these observed effects that do not involve treatment efficacy. Therefore, further investigation is required before any definitive conclusions can be drawn regarding mannitol as a treatment for" -8850005,Mannitol treats coronary artery disorder,1471,"The data suggest the need to further evaluate the physiological importance of the increase in coronary blood flow produced by mannitol in patients with coronary artery disease and indicate the possibility that mannitol might be of value in treating certain problems in patients with coronary artery disease,",True,"Is the triple 'Mannitol treats coronary artery disorder' supported by the sentence: 'The data suggest the need to further evaluate the physiological importance of the increase in coronary blood flow produced by mannitol in patients with coronary artery disease and indicate the possibility that mannitol might be of value in treating certain problems in patients with coronary artery disease,'?","Yes, the statement does provide indirect support for the phrase ""Mannitol treats coronary artery disorder"". The passage suggests that mannitol increases coronary blood flow in patients with coronary artery disease, which implies it could have therapeutic potential in treating certain problems associated with this condition. However, it is important to note that while the statement supports mannitol's potential positive effects on coronary artery disease, it does not explicitly claim that mannitol treats the disorder itself; further investigation would be required for definitive evidence." -8674974,Mannitol treats bronchiectasis,1472,The 24-h effect of mannitol on the clearance of mucus in patients with bronchiectasis.,True,Is the triple 'Mannitol treats bronchiectasis' supported by the sentence: 'The 24-h effect of mannitol on the clearance of mucus in patients with bronchiectasis.'?,"Yes, the statement does provide indirect support for the phrase ""Mannitol treats bronchiectasis"". This is because it mentions that mannitol has an effect on mucus clearance in patients with bronchiectasis over 24 hours. Improved mucus clearance is one of the desired outcomes when treating bronchiectasis, as it can help alleviate symptoms and prevent further complications. Therefore, if mannitol is shown to enhance mucus clearance in patients with bronchiectasis, it could be considered as a potential treatment option for the disease. However, it is important to note that further investigation would be necessary to fully establish mannitol as an effective treatment for bronchiectasis, including clinical trials assessing its safety and efficacy compared to other available treatments." -8007841,"Mannitol treats chronic myelogenous leukemia, BCR-ABL1 positive",1473,Treatment of chronic myelocytic leukaemia with dibromo-mannitol (myelobromol).,False,"Is the triple 'Mannitol treats chronic myelogenous leukemia, BCR-ABL1 positive' supported by the sentence: 'Treatment of chronic myelocytic leukaemia with dibromo-mannitol (myelobromol).'?","No, the phrase ""Mannitol treats chronic myelogenous leukemia, BCR-ABL1 positive"" does not receive indirect support from the statement: ""Treatment of chronic myelocytic leukaemia with dibromo-mannitol (myelobromol)."" + It is important to note that while these drugs (prednisolone and azathioprine) may have implications for inflammation and immune response, they are not equivalent to ibuprofen in terms of their mechanisms of action or their potential effects on various diseases. Similarly, membranous nephropathy is a kidney disease, unrelated to ARDS which is a severe lung condition. Therefore, even if ibuprofen were discussed in relation to ARDS in another study, it" +21214366,Ibuprofen affects bronchopulmonary dysplasia,135,"Taken together, the present study points to a strong inhibitory effect of liposomal PLP on tumor angiogenesis by reduction of the intratumoral production of the majority of pro-angiogenic factors studied and direct inhibition of endothelial cell proliferation, which is the result of high prolonged levels of prednisolone in the tumor by liposomal delivery.",False,"'Does the phrase ""Ibuprofen affects bronchopulmonary dysplasia"" receive at least indirect support from the statement: ""Taken together, the present study points to a strong inhibitory effect of liposomal PLP on tumor angiogenesis by reduction of the intratumoral production of the majority of pro-angiogenic factors studied and direct inhibition of endothelial cell proliferation, which is the result of high prolonged levels of prednisolone in the tumor by liposomal delivery.""?","No, the statement does not provide indirect support for the phrase ""Ibuprofen affects bronchopulmonary dysplasia."" The statement discusses the inhibitory effect of liposomal PLP on tumor angiogenesis through prednisolone delivery, which is unrelated to ibuprofen or bronchopulmonary dysplasia. Bronchopulmonary dysplasia is a chronic lung disease in premature infants, while the statement focuses on tumor angiogenesis in adults. Ibuprofen is mentioned in some studies as potentially having beneficial effects on bronchopulmonary dysplasia; however, it is not linked to liposomal PLP or prednisolone in any direct or indirect way in the provided statement." +20886939,Ibuprofen affects Cognitive impairment,136,Prednisolone versus dexamethasone in croup: a randomised equivalence trial.,False,"'Does the phrase ""Ibuprofen affects Cognitive impairment"" receive at least indirect support from the statement: ""Prednisolone versus dexamethasone in croup: a randomised equivalence trial.""?","No, the statement ""Prednisolone versus dexamethasone in croup: a randomised equivalence trial"" does not provide indirect support for the phrase ""Ibuprofen affects cognitive impairment."" - The statement mentions dibromo-mannitol (myelobromol), not mannitol alone. Dibromo-mannitol is a derivative of mannitol where bromine atoms have been added, significantly altering its chemical properties. Therefore, there is no implicit support for mannitol as a treatment for chronic myelogenous leukemia based on that statement alone." -7780960,Mannitol treats cystic fibrosis,1474,Inhaled mannitol is a potential mucoactive agent in cystic fibrosis patients.,True,Is the triple 'Mannitol treats cystic fibrosis' supported by the sentence: 'Inhaled mannitol is a potential mucoactive agent in cystic fibrosis patients.'?,"Yes, inhaled mannitol does receive indirect support as a potential treatment for cystic fibrosis based on the statement ""Inhaled mannitol is a potential mucoactive agent in cystic fibrosis patients."" + The study mentioned is an equivalence trial comparing the efficacy of prednisolone and dexamethasone in treating croup, a viral infection in children that causes inflammation of the upper airways. Ibuprofen is not mentioned in the study at all; therefore, there is no basis for drawing any conclusions about its effect on cognitive impairment from this study. - The key term here is ""mucoactive agent,"" which refers to substances that can alter mucus properties. Mannitol has been shown in studies to have an impact on mucus clearance in cystic fibrosis patients by improving its hydration and reducing its viscosity. This could potentially alleviate some symptoms associated with cystic fibrosis such as persistent lung infections due to thick mucus buildup in airways. + To provide indirect support for the claim about ibuprofen and cognitive impairment, one would need evidence from studies that either investigate ibuprofen use in relation to cognitive impairment specifically or explore non-steroidal anti-inflammatory drugs (NSAIDs), of which ibuprofen is one, in relation to cognitive impairment. As of now, there is no evidence in this study that can help support such a claim about ibuprofen." +18977843,Ibuprofen affects Headache,137,Use of ACTH and prednisolone in infantile spasms: experience from a developing country.,False,"'Does the phrase ""Ibuprofen affects Headache"" receive at least indirect support from the statement: ""Use of ACTH and prednisolone in infantile spasms: experience from a developing country.""?","No, the statement ""Use of ACTH and prednisolone in infantile spasms: experience from a developing country"" does not provide any direct or indirect support for the phrase ""Ibuprofen affects Headache."" - However, it is important to note that while this statement suggests mannitol may be beneficial for cystic fibrosis patients, it does not necessarily confirm that mannitol ""treats"" cystic fibrosis since treatment typically refers to managing or curing the underlying disease condition itself. Further studies would be needed to establish whether mannitol can indeed serve as a disease-modifying treatment for cystic fibrosis beyond its established role as a symptomatic therapy for improving" -7352141,Mannitol treats intracranial hypertension,1475,"CONCLUSION: Hypertonic saline, in both 3 and 23.4% concentrations, is as effective as mannitol in the treatment of intracranial hypertension observed in association with ICH.",True,"Is the triple 'Mannitol treats intracranial hypertension' supported by the sentence: 'CONCLUSION: Hypertonic saline, in both 3 and 23.4% concentrations, is as effective as mannitol in the treatment of intracranial hypertension observed in association with ICH.'?","Yes, indirectly it does support the claim that mannitol treats intracranial hypertension. The statement provided concludes that hypertonic saline is as effective as mannitol in treating intracranial hypertension associated with ICH (intracerebral hemorrhage). This implies that mannitol is indeed an effective treatment for intracranial hypertension. However, it does not necessarily mean that mannitol is superior to other treatments such as hypertonic saline nor does it provide direct evidence for mannitol's mechanism in treating intracranial hypertension." -7084538,Mannitol treats brain edema,1476,CONCLUSIONS: Acute mannitol used in patients with cerebral edema after a large hemispheric infarction does not alter midline tissue shifts or worsen neurologic status.,False,Is the triple 'Mannitol treats brain edema' supported by the sentence: 'CONCLUSIONS: Acute mannitol used in patients with cerebral edema after a large hemispheric infarction does not alter midline tissue shifts or worsen neurologic status.'?,"No, the statement does not provide indirect support for the phrase ""Mannitol treats brain edema"". In fact, it suggests that mannitol might not be effective in treating brain edema in certain situations. The conclusion states that using acute mannitol in patients with cerebral edema after a large hemispheric infarction does not alter midline tissue shifts or worsen neurologic status. This implies that mannitol may not improve conditions related to brain edema in these patients, which contradicts the idea that mannitol treats brain edema." -23769437,Temocillin treats bacterial infectious disease with sepsis,1477,The objective is to investigate if temocillin is non-inferior to carbapenems in the targeted treatment of bacteraemia due to 3GCR-E.,False,Is the triple 'Temocillin treats bacterial infectious disease with sepsis' supported by the sentence: 'The objective is to investigate if temocillin is non-inferior to carbapenems in the targeted treatment of bacteraemia due to 3GCR-E.'?,"No, the phrase ""Temocillin treats bacterial infectious disease with sepsis"" does not receive indirect support from the statement: ""The objective is to investigate if temocillin is non-inferior to carbapenems in the targeted treatment of bacteraemia due to 3GCR-E."" + The reason is that the statement discusses the use of ACTH (Adrenocorticotropic hormone) and prednisolone in treating infantile spasms in a developing country setting. It does not mention, discuss, or provide any evidence about ibuprofen or its effects on headaches. Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) commonly used as an analgesic (pain reliever) and antipyretic (fever reducer). The statement provided is focused on different substances used for treating specific medical conditions in infants, which is unrelated to ibuprofen's potential impact on headaches." +15746938,Ibuprofen affects injury,138,Bone mineral density in relation to efficacy and side effects of budesonide and prednisolone in Crohn's disease.,False,"'Does the phrase ""Ibuprofen affects injury"" receive at least indirect support from the statement: ""Bone mineral density in relation to efficacy and side effects of budesonide and prednisolone in Crohn's disease.""?","No, the statement ""Bone mineral density in relation to efficacy and side effects of budesonide and prednisolone in Crohn's disease"" does not provide indirect support for the phrase ""Ibuprofen affects injury."" The statement is about the relationship between bone mineral density, efficacy, and side effects of two specific medications used in treating Crohn's disease, budesonide and prednisolone. Ibuprofen is not mentioned in the statement, nor is there any reference made to its potential effects on injury. Therefore, there is no basis for inferring any relationship between ibuprofen use and injury based on this statement alone." +13826486,Ibuprofen affects osteoarthritis,139,OBJECTIVE: To examine the safety and efficacy of methotrexate (MTX) plus low-dose prednisolone for induction of remission in non life- or organ-threatening courses and for remission maintenance in Churg-Strauss syndrome (CSS).,False,"'Does the phrase ""Ibuprofen affects osteoarthritis"" receive at least indirect support from the statement: ""OBJECTIVE: To examine the safety and efficacy of methotrexate (MTX) plus low-dose prednisolone for induction of remission in non life- or organ-threatening courses and for remission maintenance in Churg-Strauss syndrome (CSS).""?","No, the statement does not provide any direct or indirect support for the phrase ""Ibuprofen affects osteoarthritis"". The objective of the study mentioned is focused on examining the safety and efficacy of methotrexate (MTX) plus low-dose prednisolone for induction of remission in non life- or organ-threatening courses of Churg-Strauss syndrome (CSS) and for remission maintenance in CSS. Ibuprofen is not mentioned in the statement nor is there any implicit connection that could be inferred." +13584223,Ibuprofen affects Cognitive impairment,140,OBJECTIVE: To determine whether addition of low dose prednisolone to multidrug treatment can prevent reaction and nerve function impairment in leprosy.,False,"'Does the phrase ""Ibuprofen affects Cognitive impairment"" receive at least indirect support from the statement: ""OBJECTIVE: To determine whether addition of low dose prednisolone to multidrug treatment can prevent reaction and nerve function impairment in leprosy.""?","No, the statement does not provide indirect support for the phrase ""Ibuprofen affects Cognitive impairment."" - The statement provided is focused on comparing the efficacy of temocillin versus carbapenems in treating bacteraemia caused by 3GCR-E (third-generation cephalosporin-resistant Enterobacteriaceae). This investigation does not necessarily imply that temocillin treats bacterial infectious diseases associated with sepsis; it only suggests that temocillin could be an alternative treatment option for specific bacterial infections (those caused by 3GCR-E). + The objective of the study mentioned is to determine whether low dose prednisolone can prevent reaction and nerve function impairment in leprosy when added to multidrug treatment. This study does not involve ibuprofen or cognitive impairment; therefore, it does not provide any relevant information or support for the claim about ibuprofen's effect on cognitive impairment. - Sepsis is a systemic inflammatory response syndrome caused by an infection, which can be initiated by various microorganisms (including bacteria, viruses, fungi) and not exclusively by 3GCR-E. Therefore, even if temocillin proves non-inferior in treating bacteraem" -17734631,Artesunic acid treats hepatocellular carcinoma,1478,CONCLUSION: These findings indicate that artesunate could offer a new approach to the therapy of hepatocellular carcinoma.,True,Is the triple 'Artesunic acid treats hepatocellular carcinoma' supported by the sentence: 'CONCLUSION: These findings indicate that artesunate could offer a new approach to the therapy of hepatocellular carcinoma.'?,"Yes, the statement ""CONCLUSION: These findings indicate that artesunate could offer a new approach to the therapy of hepatocellular carcinoma"" does provide indirect support for the phrase ""Artesunic acid treats hepatocellular carcinoma."" The conclusion suggests that artesunate (the sodium salt form of artesunic acid) has potential therapeutic effects on hepatocellular carcinoma based on certain findings. However, it is important to note that ""treats"" implies a direct clinical application, which may not be warranted based solely on this statement. Further investigation would be required to establish whether artesunic acid itself has therapeutic effects on hepatocellular carcinoma in clinical settings." -16415826,Artesunic acid treats Crohn disease,1479,Our data suggest a novel clinical application of artesunate as a potential therapy for Crohn's disease.,True,Is the triple 'Artesunic acid treats Crohn disease' supported by the sentence: 'Our data suggest a novel clinical application of artesunate as a potential therapy for Crohn's disease.'?,"Yes, the statement ""Our data suggest a novel clinical application of artesunate as a potential therapy for Crohn's disease"" does provide indirect support for the phrase ""Artesunic acid treats Crohn disease."" This is because it implies that artesunate has shown promise in treating Crohn's disease in a clinical context, which is consistent with the idea that artesunic acid could be an effective treatment for Crohn's disease. However, it is important to note that ""treats"" implies a more definitive effect than ""potential therapy,"" so while there is some support, it is not direct or definitive." -15681287,Artesunic acid treats breast neoplasm,1480,Taken together our in vitro and in vivo results correlate well showing for the first time that artesunate induces resistance in highly metastatic breast tumors.,False,Is the triple 'Artesunic acid treats breast neoplasm' supported by the sentence: 'Taken together our in vitro and in vivo results correlate well showing for the first time that artesunate induces resistance in highly metastatic breast tumors.'?,"No, the statement does not provide indirect support for the claim that artesunic acid treats breast neoplasm (breast cancer). In fact, it suggests quite the opposite: that artesunic acid may induce resistance in highly metastatic breast tumors. This could potentially lead to more aggressive cancer growth and poorer patient outcomes. Therefore, this statement does not support but rather contradicts the idea that artesunic acid could be an effective treatment for breast cancer." -13704055,Artesunic acid treats cytomegalovirus infection,1481,"This is the first report of treatment of cytomegalovirus infection with artesunate, for a stem cell transplant recipient with a newly identified foscarnet-resistant and ganciclovir-resistant DNA polymerase L776M mutation.",True,"Is the triple 'Artesunic acid treats cytomegalovirus infection' supported by the sentence: 'This is the first report of treatment of cytomegalovirus infection with artesunate, for a stem cell transplant recipient with a newly identified foscarnet-resistant and ganciclovir-resistant DNA polymerase L776M mutation.'?","Yes, indirectly it does lend some support. The statement provides evidence that artesunate was used successfully in treating a cytomegalovirus infection in a patient who had developed resistance to both foscarnet and ganciclovir, which are conventional treatments for such infections. However, it is important to note that this is only one case report and further studies would be needed to establish artesunic acid as an effective treatment for cytomegalovirus infection in general. Additionally, it should be noted that artesunic acid is not currently an approved treatment for cytomegalovirus infection by any major regulatory body such as the FDA in the United States. Therefore, while there is some support for the claim based on this report, it is far from definitive proof and further investigation is required before any definitive conclusions can be drawn." -13022850,Artesunic acid treats neoplasm,1482,The anticancer activity of artesunate has also been shown in human xenograft tumors in mice.,True,Is the triple 'Artesunic acid treats neoplasm' supported by the sentence: 'The anticancer activity of artesunate has also been shown in human xenograft tumors in mice.'?,"Yes, indirectly it does lend some support. The statement ""The anticancer activity of artesunate has also been shown in human xenograft tumors in mice"" suggests that artesunate, which is a derivative of artesunic acid, has demonstrated anticancer effects in preclinical studies using mouse models with human tumors (xenografts). This implies that artesunic acid might potentially have similar anticancer effects, though it is important to note that further investigation is required before making definitive conclusions about its clinical efficacy in treating neoplasms (abnormal tissue growths that can be benign or malignant). + To establish indirect support for ""Ibuprofen affects Cognitive impairment,"" one would need evidence from related studies that either demonstrate a connection between ibuprofen and cognitive impairment or involve ibuprofen in a way that implies potential effects on cognition. In this case, since neither condition is addressed in the study objective provided, we cannot infer any support for the claim about ibuprofen affecting cognitive impairment." +12659717,Ibuprofen affects Fever,141,A double-blind randomized controlled trial of infliximab associated with prednisolone in acute alcoholic hepatitis.,False,"'Does the phrase ""Ibuprofen affects Fever"" receive at least indirect support from the statement: ""A double-blind randomized controlled trial of infliximab associated with prednisolone in acute alcoholic hepatitis.""?","No, the statement does not provide direct or indirect support for the phrase ""Ibuprofen affects Fever."" The study mentioned is focused on infliximab and prednisolone in acute alcoholic hepatitis, not on ibuprofen or fever." +11207850,Ibuprofen affects peptic ulcer disease,142,EULAR randomised controlled trial of pulse cyclophosphamide and methylprednisolone versus continuous cyclophosphamide and prednisolone followed by azathioprine and prednisolone in lupus nephritis.,False,"'Does the phrase ""Ibuprofen affects peptic ulcer disease"" receive at least indirect support from the statement: ""EULAR randomised controlled trial of pulse cyclophosphamide and methylprednisolone versus continuous cyclophosphamide and prednisolone followed by azathioprine and prednisolone in lupus nephritis.""?","No, the statement does not provide any direct or indirect support for the phrase ""Ibuprofen affects peptic ulcer disease."" The EULAR randomized controlled trial mentioned in the statement is focused on comparing two different treatment regimens for lupus nephritis, which is a type of kidney inflammation associated with systemic lupus erythematosus (SLE). Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) commonly used for pain relief and reducing inflammation; however, it is not mentioned nor involved in any way in the trial described in the statement. - + Peptic ulcer disease is an inflammatory condition affecting the stomach lining and duodenum, which can be exacerbated by long-term NSAID use, including ibuprofen. However, since there is no mention of NSAIDs or ibuprofen in the statement provided, it does not offer any support for the connection between ibuprofen use and peptic ulcer disease." +11159990,Ibuprofen affects Hemorrhage,143,OBJECTIVE: To investigate the safety and efficacy of leflunomide plus low-dose prednisolone for the maintenance of remission in Wegener's granulomatosis (WG).,False,"'Does the phrase ""Ibuprofen affects Hemorrhage"" receive at least indirect support from the statement: ""OBJECTIVE: To investigate the safety and efficacy of leflunomide plus low-dose prednisolone for the maintenance of remission in Wegener's granulomatosis (WG).""?","No, the statement does not provide any direct or indirect support for the phrase ""Ibuprofen affects Hemorrhage"". The objective of the study is to investigate the safety and efficacy of leflunomide plus low-dose prednisolone for the maintenance of remission in Wegener’s granulomatosis (WG). This study does not involve Ibuprofen or hemorrhage, so it does not provide any relevant information to support the claim that Ibuprofen affects Hemorrhage." +10170540,Ibuprofen affects patent ductus arteriosus,144,"Treatment with combined therapy of adriamycin, vincristine and prednisolone produced a remission in the leukaemia with complete resolution of the breast mass.",False,"'Does the phrase ""Ibuprofen affects patent ductus arteriosus"" receive at least indirect support from the statement: ""Treatment with combined therapy of adriamycin, vincristine and prednisolone produced a remission in the leukaemia with complete resolution of the breast mass.""?","No, the statement does not provide indirect support for the phrase ""Ibuprofen affects patent ductus arteriosus."" The statement discusses the effects of a combined therapy of adriamycin, vincristine, and prednisolone on leukaemia and breast mass resolution. Ibuprofen is not mentioned in the statement; hence, there is no connection between the two statements that would allow for indirect support. - The distinction between artesunic acid and artesunate is crucial because artesunate is more soluble in water than artesunic acid, making it easier for therapeutic administration in clinical settings. The observed anticancer effects in mouse models do not automatically translate into equivalent effects in humans; however, they do provide promising leads for further exploration in clinical trials involving human patients. + To further elaborate on why there is no indirect support, let us consider some contextual aspects of both statements. Patent ductus arteriosus (PDA) is a congenital heart condition where a blood vessel called ductus arteriosus fails to close after birth as it should normally do. Ibuprofen is one of several medications used in treating PDA due to its ability to promote vasoconstriction in the ductus arteriosus. - + On the other hand, adriamycin (doxorubicin), vincristine, and prednisolone are chemotherapeutic agents commonly used in treating various types of cancer, including leukaemia. The statement provided focuses on their effectiveness" +10026104,Ibuprofen affects Myalgia,145,RESULTS: The average initial dose of prednisolone in polymyalgia rheumatica was 35 mg; 51 of 62 patients were given a starting dose exceeding 15 mg.,False,"'Does the phrase ""Ibuprofen affects Myalgia"" receive at least indirect support from the statement: ""RESULTS: The average initial dose of prednisolone in polymyalgia rheumatica was 35 mg; 51 of 62 patients were given a starting dose exceeding 15 mg.""?","No, the statement does not provide indirect support for the phrase ""Ibuprofen affects Myalgia."" The statement discusses the initial dose of prednisolone in polymyalgia rheumatica patients but does not mention ibuprofen or myalgia at all. Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) used for pain relief, while myalgia refers to muscle pain; however, there is no connection established between these concepts in the provided statement." +9889792,Ibuprofen affects Hemorrhage,146,[Trans-utero-tubal administration of prednisolone in sterility caused by obstruction of the tubes].,False,"'Does the phrase ""Ibuprofen affects Hemorrhage"" receive at least indirect support from the statement: ""[Trans-utero-tubal administration of prednisolone in sterility caused by obstruction of the tubes].""?","No, the statement does not provide any direct or indirect support for the phrase ""Ibuprofen affects Hemorrhage."" The statement discusses the administration of prednisolone in sterility caused by obstruction of the tubes, which is unrelated to ibuprofen and hemorrhage. Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) used for pain relief, while prednisolone is a corticosteroid medication used for suppressing immune response. Hemorrhage refers to excessive bleeding. These concepts are not mentioned nor implied in the given statement." +8819538,Ibuprofen affects osteoarthritis,147,[On experiences with a combination preparation from prednisolone and an antihistaminic in dermatology especially in endogenous eczema].,False,"'Does the phrase ""Ibuprofen affects osteoarthritis"" receive at least indirect support from the statement: ""[On experiences with a combination preparation from prednisolone and an antihistaminic in dermatology especially in endogenous eczema].""?","No, the statement does not provide any direct or indirect support for the phrase ""Ibuprofen affects osteoarthritis."" The statement discusses the use of prednisolone and an antihistaminic in dermatology, specifically in endogenous eczema. Ibuprofen is neither mentioned nor implied in this context. Therefore, it does not contribute to our understanding of ibuprofen's potential effects on osteoarthritis." +8421263,Ibuprofen affects Fever,148,[USE OF PREDNISOLONE IN SOME GRAVE FORMS OF PATHOLOGY OF THE PREMATURE INFANT].,False,"'Does the phrase ""Ibuprofen affects Fever"" receive at least indirect support from the statement: ""[USE OF PREDNISOLONE IN SOME GRAVE FORMS OF PATHOLOGY OF THE PREMATURE INFANT].""?","No, the statement does not provide direct or indirect support for the phrase ""Ibuprofen affects Fever."" The statement discusses the use of prednisolone in some grave forms of pathology in premature infants. Prednisolone is a corticosteroid medication, while ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID). These two medications have different mechanisms of action in the body and thus, their effects on fever may also differ. - In summary, while the statement does not explicitly confirm that artesunic acid treats neoplasms, it" -10539481,Artesunic acid treats Fever,1483,The 2 groups that received artesunate experienced considerably more rapid reduction in parasitemia and in fever than the group that received only mefloquine (p.002).,False,Is the triple 'Artesunic acid treats Fever' supported by the sentence: 'The 2 groups that received artesunate experienced considerably more rapid reduction in parasitemia and in fever than the group that received only mefloquine (p.002).'?,"No, the statement does not provide direct support for the claim that artesunic acid treats fever. The provided statement is comparing artesunate (not artesunic acid) to mefloquine in terms of reducing parasitemia and fever in two groups receiving artesunate versus one group receiving mefloquine (p=0.002). Artesunate is a different compound from artesunic acid despite their shared derivation from Artemisia annua (sweet wormwood). Artesunic acid has not been mentioned in relation to fever reduction in this statement. Therefore, it is inappropriate to infer that artesunic acid treats fever based solely on this information." -10009785,Artesunic acid treats schistosomiasis,1484,CONCLUSION: A mass chemotherapy in conjunction with health education and oral artesunate for preventing reinfection in transmission season is effective for the control of schistosomiasis in lake regions.,True,Is the triple 'Artesunic acid treats schistosomiasis' supported by the sentence: 'CONCLUSION: A mass chemotherapy in conjunction with health education and oral artesunate for preventing reinfection in transmission season is effective for the control of schistosomiasis in lake regions.'?,"Yes, indirectly it does support that statement. The conclusion mentions oral artesunate as part of an effective strategy for controlling schistosomiasis in lake regions. Artesunic acid is a derivative of artesunate, which suggests that artesunic acid could also potentially play a role in treating schistosomiasis given its relationship with artesunate. However, it is important to note that the conclusion specifically mentions oral artesunate, not artesunic acid, so further investigation would be needed to definitively say that artesunic acid is an effective treatment for schistosomiasis based on this statement alone." -9194607,Artesunic acid treats urinary schistosomiasis,1485,"Artesunate and praziquantel for the treatment of Schistosoma haematobium infections: a double-blind, randomized, placebo-controlled study.",True,"Is the triple 'Artesunic acid treats urinary schistosomiasis' supported by the sentence: 'Artesunate and praziquantel for the treatment of Schistosoma haematobium infections: a double-blind, randomized, placebo-controlled study.'?","Yes, there is indirect support for the claim that artesunic acid treats urinary schistosomiasis based on the provided statement. The study mentions artesunate, which is derived from artesunic acid, as a treatment for Schistosoma haematobium infections, which can cause urinary schistosomiasis. However, it is important to note that artesunate was used in combination with praziquantel in the study, so further research would be needed to isolate the effects of artesunic acid specifically on urinary schistosomiasis." -7990355,Artesunic acid treats Plasmodium vivax malaria,1486,"To define the current efficacy of Fansidar (F. Hoffmann-La Roche Ltd., Basel Switzerland) (pyrimethamine and sulfadoxine), primaquine in a high dose, and artesunate for treating acute Plasmodium vivax malaria, we conducted a comparative clinical trial of these 3 drugs in an open-label study.",False,"Is the triple 'Artesunic acid treats Plasmodium vivax malaria' supported by the sentence: 'To define the current efficacy of Fansidar (F. Hoffmann-La Roche Ltd., Basel Switzerland) (pyrimethamine and sulfadoxine), primaquine in a high dose, and artesunate for treating acute Plasmodium vivax malaria, we conducted a comparative clinical trial of these 3 drugs in an open-label study.'?","No, the phrase ""Artesunic acid treats Plasmodium vivax malaria"" does not receive direct support from the statement provided. The statement describes a comparative clinical trial involving Fansidar (pyrimethamine and sulfadoxine), primaquine in a high dose, and artesunate for treating acute Plasmodium vivax malaria in an open-label study. However, it does not explicitly mention Artesunic acid being used in the trial nor does it report on its efficacy against Plasmodium vivax malaria. + To provide indirect support for ""Ibuprofen affects Fever,"" there would need to be some connection between ibuprofen and fever in the statement. For instance, if the statement mentioned that ibuprofen is used to reduce fever in premature infants, then it would provide indirect support for the phrase. However, since there is no mention of ibuprofen or fever in the statement, it does not support the claim in any way." +27630106,Ibuprofen disrupts Acute Pain,149,[EFFECT OF PREDNISOLONE ON THE CARDIAC ACTIVITY IN LIVER AND KIDNEY DISEASES AND IN RHEUMATISM].,False,"'Does the phrase ""Ibuprofen disrupts Acute Pain"" receive at least indirect support from the statement: ""[EFFECT OF PREDNISOLONE ON THE CARDIAC ACTIVITY IN LIVER AND KIDNEY DISEASES AND IN RHEUMATISM].""?","No, the statement does not provide any direct or indirect support for the phrase ""Ibuprofen disrupts Acute Pain."" The statement is about the effect of Prednisolone on cardiac activity in liver and kidney diseases and in rheumatism. It does not mention Ibuprofen or acute pain at all. Therefore, it does not contribute to the validity of that specific claim." +23399675,Ibuprofen disrupts Myalgia,150,"In this limited pilot study, we compared the effect on clinical outcome of treating Pseudomonas keratitis in guinea pigs with prednisolone (a corticosteroid), flurbiprofen (a cyclo-oxygenase inhibitor), nordihydroguaiaretic acid (a lipoxygenase inhibitor), and a leukotriene antagonist, SKF104353 [R-(R*, S*)]-beta-[(2-carboxyethyl) thio-alpha-hydroxy-2-(8-phenyloctyl) benzenepropanoic acid, zinc salt].",False,"'Does the phrase ""Ibuprofen disrupts Myalgia"" receive at least indirect support from the statement: ""In this limited pilot study, we compared the effect on clinical outcome of treating Pseudomonas keratitis in guinea pigs with prednisolone (a corticosteroid), flurbiprofen (a cyclo-oxygenase inhibitor), nordihydroguaiaretic acid (a lipoxygenase inhibitor), and a leukotriene antagonist, SKF104353 [R-(R*, S*)]-beta-[(2-carboxyethyl) thio-alpha-hydroxy-2-(8-phenyloctyl) benzenepropanoic acid, zinc salt].""?","No, the statement does not provide indirect support for the phrase ""Ibuprofen disrupts Myalgia."" The study mentioned in the statement is focused on treating Pseudomonas keratitis in guinea pigs using various drugs, one of which is flurbiprofen, a cyclo-oxygenase inhibitor similar to ibuprofen. However, the study does not investigate the effect of these drugs on myalgia (muscle pain), nor does it specifically study ibuprofen. Therefore, it does not provide any evidence or support for the claim that ibuprofen disrupts myalgia." +18599970,Ibuprofen disrupts arthritic joint disease,151,URINARY EXCRETION OF PREDNISOLONE AFTER INTRARECTAL THERAPY IN ULCERATIVE COLITIS.,False,"'Does the phrase ""Ibuprofen disrupts arthritic joint disease"" receive at least indirect support from the statement: ""URINARY EXCRETION OF PREDNISOLONE AFTER INTRARECTAL THERAPY IN ULCERATIVE COLITIS.""?","No, the statement ""URINARY EXCRETION OF PREDNISOLONE AFTER INTRARECTAL THERAPY IN ULCERATIVE COLITIS"" does not provide indirect support for the phrase ""Ibuprofen disrupts arthritic joint disease."" - That said, one could argue that there is indirect support if the study found artesunate (which is similar in structure and mechanism to Artesunic acid) effective in treating Plasmodium vivax malaria. However, without explicit evidence regarding Artesunic acid itself, we cannot definitively say that it receives support from the statement provided." -7595063,Artesunic acid treats malaria,1487,Artemether and artesunate have also been administered by the rectal route with highly promising results for treatment of severe malaria.,True,Is the triple 'Artesunic acid treats malaria' supported by the sentence: 'Artemether and artesunate have also been administered by the rectal route with highly promising results for treatment of severe malaria.'?,"Yes, there is indirect support for the claim that artesunic acid treats malaria based on the provided statement. Artemether and artesunate are both derived from artemisinin, which is the active ingredient in artesunic acid. These compounds have demonstrated efficacy in treating severe malaria when administered via the rectal route. Therefore, it can be inferred that artemisinin-based treatments like artesunic acid could potentially treat malaria as well. However, it is important to note that direct clinical evidence specifically involving artesunic acid is not provided in the statement; hence, the support is indirect." -7113713,Artesunic acid treats Plasmodium falciparum malaria,1488,Declining concentrations of dihydroartemisinin in plasma during 5-day oral treatment with artesunate for Falciparum malaria.,False,Is the triple 'Artesunic acid treats Plasmodium falciparum malaria' supported by the sentence: 'Declining concentrations of dihydroartemisinin in plasma during 5-day oral treatment with artesunate for Falciparum malaria.'?,"No, the statement does not provide direct or indirect support for the claim that artesunic acid treats Plasmodium falciparum malaria. The statement discusses declining concentrations of dihydroartemisinin in plasma during 5-day oral treatment with artesunate for Falciparum malaria. Artesunate is a medication that is metabolized into dihydroartemisinin in the body. The decreasing concentrations of dihydroartemisinin in plasma could be attributed to various factors such as metabolism rate changes, dosage adjustments, or individual variability in drug response rather than an indication that artesunic acid is effective in treating Plasmodium falciparum malaria. + The statement is about the excretion of Prednisolone, a corticosteroid used in treating inflammatory conditions such as ulcerative colitis, after intrarectal therapy. This has no direct or indirect relation to Ibuprofen, which is a non-steroidal anti-inflammatory drug (NSAID) used for pain relief, fever reduction, and inflammation reduction. The two substances have different mechanisms of action and are used for different medical conditions. Therefore, any conclusions about Ibuprofen's effect on arthritic joint disease cannot be drawn from this statement." +15072611,Ibuprofen disrupts Fever,152,"Male rats treated with either budesonide, prednisolone, or triamcinolone acetonide in drinking water for up to 104 weeks developed slightly increased incidences of basophilic foci, and significantly increased incidences of combined hepatocellular adenomas/carcinomas as compared to controls.",False,"'Does the phrase ""Ibuprofen disrupts Fever"" receive at least indirect support from the statement: ""Male rats treated with either budesonide, prednisolone, or triamcinolone acetonide in drinking water for up to 104 weeks developed slightly increased incidences of basophilic foci, and significantly increased incidences of combined hepatocellular adenomas/carcinomas as compared to controls.""?","No, the statement does not provide indirect support for the phrase ""Ibuprofen disrupts Fever."" The statement discusses the effects of three different glucocorticoids (budesonide, prednisolone, and triamcinolone acetonide) on male rats over an extended period (up to 104 weeks), focusing on increased incidences of basophilic foci and hepatocellular adenomas/carcinomas. Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) unrelated to glucocorticoids; it works by inhibiting cyclooxygenase enzymes involved in inflammation and pain signaling but does not share the same mechanism as glucocorticoids in suppressing immune response. - Artesunic acid is structurally similar but distinct from artesunate; they both belong to the artemisinin class of antimalarial drugs derived from Artemisia annua (sweet wormwood). While artesunate has been proven effective in treating malaria caused by Plasmodium falciparum, there is no direct evidence presented in the statement that artesunic acid shares these therapeutic properties." -7264251,Artemether treats malaria,1489,These data demonstrate the equality of artemether and quinine for severe malaria and indicate a trend toward greater effectiveness of artemether in regions where there is recognized quinine resistance.,True,Is the triple 'Artemether treats malaria' supported by the sentence: 'These data demonstrate the equality of artemether and quinine for severe malaria and indicate a trend toward greater effectiveness of artemether in regions where there is recognized quinine resistance.'?,"Yes, the statement does provide indirect support for the claim that Artemether treats malaria. The key phrase here is ""greater effectiveness of artemether in regions where there is recognized quinine resistance."" This implies that Artemether is indeed effective against malaria, at least in areas where quinine resistance is prevalent. However, it doesn't directly state that Artemether treats malaria in all cases or regions, hence the indirect support. + Ibuprofen can impact fever through its action on prostaglandin synthesis; however, the statement provided does not contain information about fever disruption nor does it involve ibuprofen in any capacity. To establish indirect support for ""Ibuprofen disrupts Fever,"" there should be some connection between ibuprofen use and fever" +14486259,Ibuprofen disrupts Pain,153,[On the use of prednisolone in hemolytic anemia of the newborn caused by fetomaternal Rh-factor incompatibility].,False,"'Does the phrase ""Ibuprofen disrupts Pain"" receive at least indirect support from the statement: ""[On the use of prednisolone in hemolytic anemia of the newborn caused by fetomaternal Rh-factor incompatibility].""?","No, the statement does not provide indirect support for the phrase ""Ibuprofen disrupts Pain"". The statement pertains specifically to the use of prednisolone in hemolytic anemia of the newborn caused by fetomaternal Rh-factor incompatibility. It does not mention ibuprofen or pain disruption. Therefore, it does not offer any relevant information that could be used to infer support for the stated phrase." +8331095,Ibuprofen disrupts Alzheimer disease,154,Long-term use of prednisone and prednisolone in juvenile rheumatoid arthritis; a report of fifteen cases.,False,"'Does the phrase ""Ibuprofen disrupts Alzheimer disease"" receive at least indirect support from the statement: ""Long-term use of prednisone and prednisolone in juvenile rheumatoid arthritis; a report of fifteen cases.""?","No, the statement ""Long-term use of prednisone and prednisolone in juvenile rheumatoid arthritis; a report of fifteen cases"" does not provide indirect support for the phrase ""Ibuprofen disrupts Alzheimer disease."" - The statement also mentions a comparison between Artemether and Quinine, both of which are antimalarial drugs. The comparison suggests that Artemether is as effective as Quinine in treating severe malaria, and potentially more effective in certain regions due to quinine resistance. This further strengthens the inference that Artemether is an effective treatment for malaria. + The reason is that these two statements discuss different drugs (ibuprofen vs prednisone/prednisolone) used in different medical conditions (Alzheimer disease vs juvenile rheumatoid arthritis). There is no mention of ibuprofen, Alzheimer disease, or any link between them in the provided statement about prednisone/prednisolone use in juvenile rheumatoid arthritis. - However, it's important to note that while this statement provides some evidence for the effectiveness of Artemether in treating malaria, it doesn't cover all aspects of its use, such as potential side effects, dosage, or its effectiveness against different strains of malaria. Therefore, while the statement does provide some support for the claim that Artemether" -7168046,Artemether treats Plasmodium falciparum malaria,1490,"The spectrum of falciparum malaria treatment has recently broadened to include new drugs such as artemisinin, artemether or atovaquone/proguanil, the latter being as yet unauthorized in France.",True,"Is the triple 'Artemether treats Plasmodium falciparum malaria' supported by the sentence: 'The spectrum of falciparum malaria treatment has recently broadened to include new drugs such as artemisinin, artemether or atovaquone/proguanil, the latter being as yet unauthorized in France.'?","Yes, the statement does provide indirect support for the claim that Artemether treats Plasmodium falciparum malaria. The statement mentions Artemether as one of the new drugs that have broadened the spectrum of falciparum malaria treatment. This implies that Artemether is indeed used in treating Plasmodium falciparum malaria, although it does not provide direct clinical trial results or mechanistic details. However, it is important to note that while Artemether is an effective antimalarial drug, it is typically used in combination therapy due to the emergence of drug-resistant strains of Plasmodium falciparum." -25827221,Isoproterenol treats obstructive lung disease,1491,Investigation into isoprenaline resistance in patients with obstructive lung disease.,False,Is the triple 'Isoproterenol treats obstructive lung disease' supported by the sentence: 'Investigation into isoprenaline resistance in patients with obstructive lung disease.'?,"No, the statement ""Investigation into isoprenaline resistance in patients with obstructive lung disease"" does not provide direct or indirect support for the claim that ""Isoproterenol treats obstructive lung disease."" + To establish indirect support for the claim about ibuprofen and Alzheimer disease, one would need evidence that demonstrates shared mechanisms between these drugs or conditions that could suggest potential disruption of Alzheimer disease by ibuprofen. However, based on the given statement alone, no such link can be inferred." +25657729,Ibuprofen prevents hypertensive disorder,155,[Effect of prednisolone and human albumin on protein excretion in nephrotic syndrome].,False,"'Does the phrase ""Ibuprofen prevents hypertensive disorder"" receive at least indirect support from the statement: ""[Effect of prednisolone and human albumin on protein excretion in nephrotic syndrome].""?","No, the statement ""Ibuprofen prevents hypertensive disorder"" does not receive any direct or indirect support from the title ""[Effect of prednisolone and human albumin on protein excretion in nephrotic syndrome]."" This title discusses the effect of prednisolone and human albumin on protein excretion in nephrotic syndrome patients, which is unrelated to ibuprofen use or hypertensive disorders prevention." +22159382,Ibuprofen prevents Hemorrhage,156,[Therapeutic results of metacortandralone or prednisolone in allergy].,False,"'Does the phrase ""Ibuprofen prevents Hemorrhage"" receive at least indirect support from the statement: ""[Therapeutic results of metacortandralone or prednisolone in allergy].""?","No, the statement ""Ibuprofen prevents Hemorrhage"" does not receive any direct or indirect support from the statement ""[Therapeutic results of metacortandralone or prednisolone in allergy]."" - Isoproterenol is also known as isoprenaline in some regions. While this investigation may involve studying isoproterenol resistance in patients with obstructive lung disease, it does not necessarily imply that isoproterenol is used as a treatment for the disease. In fact, it could suggest that isoproterenol is part of the problem (i.e., contributing to resistance). Therefore, without additional information linking isoproterenol use as a treatment for obstructive lung disease in this context, it is not appropriate to infer support for that claim." -15441635,Isoproterenol treats lipoma,1492,AIM: The aim of this study was to evaluate the efficacy of isoproterenol and prednisolone in the treatment of subcutaneous lipomas.,True,Is the triple 'Isoproterenol treats lipoma' supported by the sentence: 'AIM: The aim of this study was to evaluate the efficacy of isoproterenol and prednisolone in the treatment of subcutaneous lipomas.'?,"Yes, the phrase ""Isoproterenol treats lipoma"" does receive indirect support from the statement provided. The statement indicates that the aim of the study was to evaluate the efficacy of isoproterenol in the treatment of subcutaneous lipomas. This implies that isoproterenol is being used as a treatment for lipomas in this study, which aligns with the phrase ""Isoproterenol treats lipoma"". However, it is important to note that direct support would require more specific information about the outcomes of the study and whether isoproterenol was found to be effective in treating lipomas." -13881275,Isoproterenol treats orthostatic hypotension,1493,"Microdialysate concentrations of the main neuronal metabolite of norepinephrine (NE) and dihydroxyphenylglycol (DHPG) were measured in skeletal muscle, and plasma concentrations of NE and DHPG were measured in response to i.v. tyramine, yohimbine, and isoproterenol, in patients with PD+NOH, patients with pure autonomic failure (PAF), which is characterized by generalized catecholaminergic denervation, and control subjects.",False,"Is the triple 'Isoproterenol treats orthostatic hypotension' supported by the sentence: 'Microdialysate concentrations of the main neuronal metabolite of norepinephrine (NE) and dihydroxyphenylglycol (DHPG) were measured in skeletal muscle, and plasma concentrations of NE and DHPG were measured in response to i.v. tyramine, yohimbine, and isoproterenol, in patients with PD+NOH, patients with pure autonomic failure (PAF), which is characterized by generalized catecholaminergic denervation, and control subjects.'?","No, the statement does not provide direct support for the claim that ""Isoproterenol treats orthostatic hypotension"". The study measures concentrations of certain metabolites in response to various substances including isoproterenol in different groups of patients but does not explicitly evaluate its effectiveness in treating orthostatic hypotension. Therefore, while it may provide indirect evidence if interpreted in conjunction with other studies showing such an effect, it does not directly support the claim on its own." -11481186,Isoproterenol treats atrial fibrillation,1494,"RESULTS: LAP series analysis shows a reduction of both LP and R index during isoproterenol infusion in SR and AF (RSR = 0.75 +/- 0.07 RSRISO = 0.69 +/- 0.10, p < 0.0001; RAF = 0.31 +/- 0.08 RAFISO = 0.26 +/- 0.09, p < 0.0001; LPSR = 99.99 +/- 0.001 LPSRISO = 99.97 +/- 0.03, p < 0.0001; LPAF = 69.46 +/- 21.55 LPAFISO = 55 +/- 24.75; p < 0.0001).",False,"Is the triple 'Isoproterenol treats atrial fibrillation' supported by the sentence: 'RESULTS: LAP series analysis shows a reduction of both LP and R index during isoproterenol infusion in SR and AF (RSR = 0.75 +/- 0.07 RSRISO = 0.69 +/- 0.10, p < 0.0001; RAF = 0.31 +/- 0.08 RAFISO = 0.26 +/- 0.09, p < 0.0001; LPSR = 99.99 +/- 0.001 LPSRISO = 99.97 +/- 0.03, p < 0.0001; LPAF = 69.46 +/- 21.55 LPAFISO = 55 +/- 24.75; p < 0.0001).'?","No, the statement does not provide direct support for the claim that ""Isoproterenol treats atrial fibrillation."" However, it does offer indirect evidence suggesting that isoproterenol may have an effect on atrial fibrillation (AF) based on changes in certain indices (LP, R) during isoproterenol infusion in both sinus rhythm (SR) and AF states. + The reason for this is that the two statements discuss different subjects. The first statement refers to Ibuprofen, an anti-inflammatory drug often used for pain relief and fever reduction, and its potential effect on preventing hemorrhage (bleeding). The second statement discusses the therapeutic results of two different drugs, metacortandralone and prednisolone, in the context of allergy treatment. - The statement reports results from a study using isoproterenol infusion in SR and AF states while measuring changes in LP and R indices (LPSR, LPAF, RSR, RAF). The results show that there is a statistically significant" -9565866,Isoproterenol treats obesity disorder,1495,Decreased responsiveness to isoproterenol in obesity may be due to defects downstream of adenylyl cyclase activation of cyclic AMP.,False,Is the triple 'Isoproterenol treats obesity disorder' supported by the sentence: 'Decreased responsiveness to isoproterenol in obesity may be due to defects downstream of adenylyl cyclase activation of cyclic AMP.'?,"No, the statement does not provide indirect support for the phrase ""Isoproterenol treats obesity disorder"". The original statement suggests that obese individuals have decreased responsiveness to isoproterenol due to defects downstream of adenylyl cyclase activation of cyclic AMP. This implies that isoproterenol may not be effective in treating obesity because obese individuals do not respond well to it. Therefore, the statement seems to indicate that isoproterenol might not be an appropriate treatment for obesity disorder." -8710440,Isoproterenol treats postural orthostatic tachycardia syndrome,1496,the responses of heart rate and the plasma cyclic AMP (cAMP) level to isoproterenol infusion in the supine position were evaluated in 10 POTS patients and 10 age-matched controls.,True,Is the triple 'Isoproterenol treats postural orthostatic tachycardia syndrome' supported by the sentence: 'the responses of heart rate and the plasma cyclic AMP (cAMP) level to isoproterenol infusion in the supine position were evaluated in 10 POTS patients and 10 age-matched controls.'?,"Yes, indirectly it does lend some support. The statement mentions that isoproterenol infusion in the supine position was evaluated in terms of heart rate responses and plasma cyclic AMP (cAMP) level in both POTS patients and age-matched controls. This suggests that isoproterenol has been studied in relation to postural orthostatic tachycardia syndrome (POTS). However, it does not explicitly state that isoproterenol treats POTS; it only explores its effects on heart rate and cAMP levels in POTS patients. + There is no mention of Ibuprofen, hemorrhage, or any related concepts in the second statement. Therefore, it does not provide any support for the first statement. This is an example of how correlation does not imply causation; just because two things are mentioned together does not mean they have any direct relationship." +22123299,Ibuprofen prevents Fever,157,Primary resistance to vincristine (Vcr) and prednisolone in untreated AML was observed as well as 'acquired' resistance to several other antileukemic drugs.,False,"'Does the phrase ""Ibuprofen prevents Fever"" receive at least indirect support from the statement: ""Primary resistance to vincristine (Vcr) and prednisolone in untreated AML was observed as well as 'acquired' resistance to several other antileukemic drugs.""?","No, the statement does not provide indirect support for the phrase ""Ibuprofen prevents fever."" The statement discusses resistance to certain drugs in acute myeloid leukemia (AML) patients but does not mention ibuprofen or fever at all. Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) commonly used for its analgesic (pain-relieving), antipyretic (fever-reducing), and anti-inflammatory properties. The provided statement has no relevance to ibuprofen's ability to prevent fever." +21354514,Ibuprofen prevents pancreatitis,158,"REPORT of the Committee on New Drugs of the Research Council of the American Academy of Allergy, 1955-56; studies on prednisone and prednisolone in ragweed pollinosis.",False,"'Does the phrase ""Ibuprofen prevents pancreatitis"" receive at least indirect support from the statement: ""REPORT of the Committee on New Drugs of the Research Council of the American Academy of Allergy, 1955-56; studies on prednisone and prednisolone in ragweed pollinosis.""?","No, the statement does not provide any direct or indirect support for the claim that ibuprofen prevents pancreatitis. The report mentioned is about studies on prednisone and prednisolone in ragweed pollinosis conducted in 1955-56. Ibuprofen is not mentioned in the statement, nor is there any connection made between non-steroidal anti-inflammatory drugs (NSAIDs) like ibuprofen and pancreatitis prevention. Therefore, it is not appropriate to draw such conclusions based on this information alone." +20691057,Ibuprofen prevents altitude sickness,159,Effects of prednisone and prednisolone in ocular inflammation.,False,"'Does the phrase ""Ibuprofen prevents altitude sickness"" receive at least indirect support from the statement: ""Effects of prednisone and prednisolone in ocular inflammation.""?","No, the statement ""Effects of prednisone and prednisolone in ocular inflammation"" does not provide indirect support for the claim ""Ibuprofen prevents altitude sickness."" - To make stronger conclusions about isoproterenol as a treatment for POTS, further information would be needed such as randomized controlled trials demonstrating its efficacy in treating POTS symptoms compared to placebo or other treatments. The current statement is limited in scope as it only presents a correlation between isoproterenol administration and physiological measurements in POTS patients without establishing causation or therapeutic benefits." -10687311,Metaproterenol treats obstructive lung disease,1497,ORCIPRENALINE IN TREATMENT OF AIRWAYS OBSTRUCTION IN CHRONIC BRONCHITIS.,True,Is the triple 'Metaproterenol treats obstructive lung disease' supported by the sentence: 'ORCIPRENALINE IN TREATMENT OF AIRWAYS OBSTRUCTION IN CHRONIC BRONCHITIS.'?,"Yes, there is indirect support for the claim that ""Metaproterenol treats obstructive lung disease"". This is based on the statement ""ORCIPRENALINE IN TREATMENT OF AIRWAYS OBSTRUCTION IN CHRONIC BRONCHITIS."" + The reason is that these two statements refer to different drugs (prednisone/prednisolone vs ibuprofen) and different conditions (ocular inflammation vs altitude sickness). There is no shared element between these statements that would allow for indirect support to be inferred. - The reason behind this is that Orciprenaline (also known as Metaproterenol) is a medication used to treat conditions associated with obstructive lung disease, such as chronic bronchitis. Both Orciprenaline and Metaproterenol are short-acting beta-2 adrenergic agonists (SABAs) that help relax muscles in the airways and increase airflow to the lungs, making it easier to breathe. + Furthermore, even if the two statements were about the same drug, indirect support would still not be automatically established. Indirect support refers to evidence that does not directly address the claim but provides a basis for inferring its validity based on related information. For example, if there were studies showing that ibuprofen reduces inflammation (a key factor in altitude sickness), then one might infer indirect support for the claim that ibuprofen prevents altitude sickness. However, without such a link, no indirect support can be established." +19399624,Ibuprofen prevents osteoarthritis,160,"Prednisolone scored better than prednisone in the categories of texture, taste, and aftertaste (p < 0.05); there was no statistical difference in smell.",False,"'Does the phrase ""Ibuprofen prevents osteoarthritis"" receive at least indirect support from the statement: ""Prednisolone scored better than prednisone in the categories of texture, taste, and aftertaste (p < 0.05); there was no statistical difference in smell.""?","No, the statement does not provide any indirect support for the phrase ""Ibuprofen prevents osteoarthritis"". The provided statement compares prednisolone and prednisone in terms of texture, taste, and aftertaste as well as smell. The comparison drugs have no relation to ibuprofen, which is an analgesic used for pain relief rather than an anti-inflammatory drug used for treating osteoarthritis symptoms. Therefore, there is no connection between these two statements in terms of their subject matter." +17687542,Ibuprofen prevents canker sore,161,Plasma prednisolone levels after administration of prednisolone-21-phosphate as a retention enema in colitis.,False,"'Does the phrase ""Ibuprofen prevents canker sore"" receive at least indirect support from the statement: ""Plasma prednisolone levels after administration of prednisolone-21-phosphate as a retention enema in colitis.""?","No, the statement does not provide indirect support for the phrase ""Ibuprofen prevents canker sores."" The statement discusses plasma prednisolone levels after administration of prednisolone-21-phosphate as a retention enema in colitis. This has no direct or indirect relation to ibuprofen or canker sores. Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID), while prednisolone is a corticosteroid, and they have different mechanisms of action. Furthermore, canker sores (aphthous ulcers) are not typically associated with colitis or inflammatory bowel disease. Therefore, there is no connection between these two pieces of information." +15961024,Ibuprofen prevents Dysmenorrhea,162,Mizoribine as an effective combined maintenance therapy with prednisolone in child-onset systemic lupus erythematosus.,False,"'Does the phrase ""Ibuprofen prevents Dysmenorrhea"" receive at least indirect support from the statement: ""Mizoribine as an effective combined maintenance therapy with prednisolone in child-onset systemic lupus erythematosus.""?","No, the statement does not provide any direct or indirect support for the phrase ""Ibuprofen prevents Dysmenorrhea"". The statement discusses mizoribine as an effective combined maintenance therapy with prednisolone in child-onset systemic lupus erythematosus. This is unrelated to ibuprofen and its potential effects on dysmenorrhea (menstrual pain). Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) commonly used for pain relief, including dysmenorrhea, but the provided statement does not discuss or imply this use in any way." +13710734,Ibuprofen prevents Chronic pain,163,Controlled prospective trial of prednisolone and cytotoxics in progressive IgA nephropathy.,False,"'Does the phrase ""Ibuprofen prevents Chronic pain"" receive at least indirect support from the statement: ""Controlled prospective trial of prednisolone and cytotoxics in progressive IgA nephropathy.""?","No, the statement ""Controlled prospective trial of prednisolone and cytotoxics in progressive IgA nephropathy"" does not provide indirect support for the phrase ""Ibuprofen prevents Chronic pain."" The study referenced in the statement is focused on the treatment of IgA nephropathy, a kidney disease, using prednisolone and cytotoxics, not ibuprofen. Furthermore, it does not discuss chronic pain as an outcome measure in any capacity. Therefore, it is not relevant in supporting the claim that ibuprofen prevents chronic pain." +10201705,Ibuprofen prevents Headache,164,"We propose that FE(NO) is associated with eosinophilic inflammation in children with difficult asthma, following prednisolone, and may help in identifying patients in whom persistent symptoms are associated with airway eosinophilia.",False,"'Does the phrase ""Ibuprofen prevents Headache"" receive at least indirect support from the statement: ""We propose that FE(NO) is associated with eosinophilic inflammation in children with difficult asthma, following prednisolone, and may help in identifying patients in whom persistent symptoms are associated with airway eosinophilia.""?","No, the statement does not provide indirect support for the phrase ""Ibuprofen prevents Headache."" The statement discusses the association between fractional exhaled nitric oxide (FeNO) levels and eosinophilic inflammation in children with difficult asthma who have taken prednisolone. It does not mention ibuprofen or headaches at all; therefore, it does not offer any form of support for that specific claim." +10026105,Ibuprofen prevents Myalgia,165,"Liposomal daunorubicin (DaunoXome) in combination with cyclophosphamide, vincristine and prednisolone (COP-X) as salvage therapy in poor-prognosis non-Hodgkins lymphoma.",False,"'Does the phrase ""Ibuprofen prevents Myalgia"" receive at least indirect support from the statement: ""Liposomal daunorubicin (DaunoXome) in combination with cyclophosphamide, vincristine and prednisolone (COP-X) as salvage therapy in poor-prognosis non-Hodgkins lymphoma.""?","No, the statement does not provide any direct or indirect support for the phrase ""Ibuprofen prevents Myalgia"". The two statements discuss different subjects - one is about liposomal daunorubicin in combination therapy for non-Hodgkins lymphoma, while the other is about ibuprofen preventing myalgia (muscle pain). There is no overlap in these concepts that would allow us to infer any support for the claim regarding ibuprofen preventing myalgia based on the given statement about daunorubicin in lymphoma treatment." +9104502,Ibuprofen prevents injury,166,Prednisolone in Duchenne muscular dystrophy.,False,"'Does the phrase ""Ibuprofen prevents injury"" receive at least indirect support from the statement: ""Prednisolone in Duchenne muscular dystrophy.""?","No, the statement ""Prednisolone in Duchenne muscular dystrophy"" does not provide indirect support for the phrase ""Ibuprofen prevents injury."" These two statements pertain to different medical contexts and substances. - Although the statement does not explicitly mention Metaproterenol by name, it refers to Orciprenaline, which is pharmacologically equivalent to Metaproterenol. Therefore, it can be inferred that Metaproterenol does indeed have a role in treating obstructive lung disease, specifically in managing airways obstruction in chronic bronchitis. + + The first statement refers specifically to prednisolone, which is a corticosteroid medication often used in treating Duchenne muscular dystrophy (DMD), a genetic disorder characterized by progressive muscle degeneration and weakness. Corticosteroids like prednisolone have been shown to have anti-inflammatory effects that can help slow muscle degeneration in DMD patients. - However, it is important to note" -21781034,Bacitracin A treats Infection,1498,"Based on these observations, the combination of CBD and BAC is suggested to be a putative novel treatment in clinical settings for treatment of infections with antibiotic resistant Gram-positive bacteria.",False,"Is the triple 'Bacitracin A treats Infection' supported by the sentence: 'Based on these observations, the combination of CBD and BAC is suggested to be a putative novel treatment in clinical settings for treatment of infections with antibiotic resistant Gram-positive bacteria.'?","No, the phrase ""Bacitracin A treats Infection"" does not receive direct support from the statement provided. The statement suggests that a combination therapy involving both CBD (cannabidiol) and BAC (Bacitracin A) may be an effective treatment for infections caused by antibiotic-resistant Gram-positive bacteria. However, it does not specifically indicate that Bacitracin A alone is sufficient for treating infections. Therefore, while Bacitracin A might be part of an effective treatment regimen when used in combination with CBD in specific cases as suggested by the statement, it does not provide direct evidence that Bacitracin A alone can treat infections." -17678351,Bacitracin A treats bacterial infectious disease,1499,"Thus, the bacitracin and gramicidin S-based self-assembled nanopeptide ribbon may be a successful ointment formulation for bacterial infection control.",True,"Is the triple 'Bacitracin A treats bacterial infectious disease' supported by the sentence: 'Thus, the bacitracin and gramicidin S-based self-assembled nanopeptide ribbon may be a successful ointment formulation for bacterial infection control.'?","Yes, indirectly it does lend some support. The statement mentions that bacitracin-based nanopeptide ribbon has potential as an ointment formulation for bacterial infection control. Bacitracin is known for its antibacterial properties which can be effective in treating bacterial infectious diseases. However, it is important to note that while bacitracin has antibacterial properties, it does not necessarily mean that it can treat all bacterial infectious diseases as there may be various factors such as bacterial resistance, severity of infection, etc., that can influence its effectiveness in treatment." -11891842,Bacitracin A treats burn,1500,"Consensus was found regarding most local (topical) wound care, (SSD for clean non-facial burns, Sulfamylon (mafenide-acetate) for contaminated non-facial burns, Threolone (chloramphenicol 3% and prednisolone 0.5%) or Bacitracin for facial burns, Paraffin gauzes with or without Sulfamylon for donor and graft sites).",True,"Is the triple 'Bacitracin A treats burn' supported by the sentence: 'Consensus was found regarding most local (topical) wound care, (SSD for clean non-facial burns, Sulfamylon (mafenide-acetate) for contaminated non-facial burns, Threolone (chloramphenicol 3% and prednisolone 0.5%) or Bacitracin for facial burns, Paraffin gauzes with or without Sulfamylon for donor and graft sites).'?","Yes, the statement does provide indirect support for the claim that Bacitracin A treats burns, specifically facial burns. The consensus statement includes Bacitracin as an option for local wound care in facial burns, suggesting its appropriateness in such situations due to its inclusion in expert opinion. However, it is crucial to note that correlation does not imply causation; therefore, while Bacitracin is recommended for facial burns, it does not necessarily mean it is the active treatment agent causing improvement in burns. Other factors such as wound care best practices may contribute significantly to burn healing." -26452786,Fenbendazole causes helminthiasis,101,The anti-ischemic mechanism of action of ranolazine in stable ischemic heart disease.,False,Is the triple 'Fenbendazole causes helminthiasis' supported by the sentence: 'The anti-ischemic mechanism of action of ranolazine in stable ischemic heart disease.'?,"No, the statement ""The anti-ischemic mechanism of action of ranolazine in stable ischemic heart disease"" does not provide any indirect support for the claim ""Fenbendazole causes helminthiasis."" These two statements discuss entirely different subjects: one is about a medication used for treating ischemic heart disease (ranolazine), while the other pertains to an anthelmintic drug (fenbendazole) possibly causing helminthiasis (a helminth infection). Thus, there is no logical connection between these two statements that would allow one to indirectly support the other." -22762728,Fenbendazole prevents helminthiasis,102,Atrial-selective/predominant sodium channel blockers such as ranolazine effectively suppress AF in experimental models of AF involving canine isolated right atrial preparations at concentrations that produce little to no effect on ventricular electrophysiologic parameters.,False,Is the triple 'Fenbendazole prevents helminthiasis' supported by the sentence: 'Atrial-selective/predominant sodium channel blockers such as ranolazine effectively suppress AF in experimental models of AF involving canine isolated right atrial preparations at concentrations that produce little to no effect on ventricular electrophysiologic parameters.'?,"No, the statement does not provide any direct or indirect support for the claim that Fenbendazole prevents helminthiasis. + + Ibuprofen, on the other hand, is a non-steroidal anti-inflammatory drug (NSAID) commonly used for relieving pain, reducing inflammation, and bringing down fever in various conditions unrelated to muscular dystrophy. While ibuprofen does have anti-inflammatory properties like prednisolone, there is no direct link between these two statements in terms of their medical contexts, applications, or implications for injury prevention. - The statement discusses the effects of atrial-selective/predominant sodium channel blockers, specifically ranolazine, on atrial fibrillation (AF) in canine isolated right atrial preparations. It does not mention Fenbendazole or helminthiasis at all. + + It" +9022792,Ibuprofen prevents Pain,167,Intravenous prednisolone in chronic bronchial asthma.,False,"'Does the phrase ""Ibuprofen prevents Pain"" receive at least indirect support from the statement: ""Intravenous prednisolone in chronic bronchial asthma.""?","No, the statement ""Intravenous prednisolone in chronic bronchial asthma"" does not provide indirect support for the phrase ""Ibuprofen prevents Pain."" - Helminthiasis is a condition characterized by infection with parasitic worms, which Fenbendazole is known to treat. However, there is no connection made in the statement between Fenbendazole and helminthiasis prevention, nor between ranolazine, AF, and potential anti-parasitic effects that could indirectly support the claim about Fenbendazole. + The statement in question is about the use of intravenous prednisolone in managing chronic bronchial asthma, which is an inflammatory disease of the airways. This has no direct relevance or implication for the use of ibuprofen, which is a non-steroidal anti-inflammatory drug (NSAID) commonly used for pain relief and reducing inflammation in conditions like arthritis and menstrual cramps. - To establish support for the claim about Fenbendazole preventing helminthiasis, one would need evidence specifically pertaining to Fenbendazole's effectiveness in preventing or treating helminthiasis in appropriate models or clinical settings." -21848143,Albendazole causes helminthiasis,103,Ranolazine has been shown to decrease angina pectoris frequency and nitroglycerin consumption.,False,Is the triple 'Albendazole causes helminthiasis' supported by the sentence: 'Ranolazine has been shown to decrease angina pectoris frequency and nitroglycerin consumption.'?,"No, the statement ""Ranolazine has been shown to decrease angina pectoris frequency and nitroglycerin consumption"" does not provide any indirect support for the claim that ""Albendazole causes helminthiasis."" These two statements discuss unrelated subjects: one is about a medication used to treat angina pectoris (ranolazine) while the other is about an anti-parasitic drug (albendazole) that can potentially cause helminthiasis as an adverse effect in rare cases. The statements come from different areas in medical science - cardiology and parasitology respectively - without any overlap in their implications." -25735916,Albendazole affects trichuriasis,104,BACKGROUND: Ranolazine has been shown to reduce myocardial ischemia and symptom severity among selected patients with chronic angina.,False,Is the triple 'Albendazole affects trichuriasis' supported by the sentence: 'BACKGROUND: Ranolazine has been shown to reduce myocardial ischemia and symptom severity among selected patients with chronic angina.'?,"No, the statement does not provide indirect support for the phrase ""Albendazole affects trichuriasis."" The background statement discusses Ranolazine, its effects on myocardial ischemia, and its impact on symptom severity in certain patients with chronic angina. This information is unrelated to Albendazole, which is an anthelmintic drug used for treating parasitic worm infections such as trichuriasis. Therefore, it does not offer any indirect evidence or support for the claim that Albendazole affects trichuriasis." -24685635,Albendazole affects filarial elephantiasis,105,"Dominant frequency (DF) of AF was reduced by ranolazine in left atrium from 11.7 (10.7-20.5) Hz to 7.6 (2.9-8.8) Hz (P = 0.02, n = 6).",False,"Is the triple 'Albendazole affects filarial elephantiasis' supported by the sentence: 'Dominant frequency (DF) of AF was reduced by ranolazine in left atrium from 11.7 (10.7-20.5) Hz to 7.6 (2.9-8.8) Hz (P = 0.02, n = 6).'?","No, the statement does not provide any direct or indirect support for the phrase ""Albendazole affects filarial elephantiasis"". The statement discusses the effect of ranolazine on the dominant frequency (DF) of atrial fibrillation (AF) in humans, whereas albendazole is an antiparasitic drug used primarily for treating soil-transmitted helminthiases (intestinal worm infections) and filarial diseases such as lymphatic filariasis (elephantiasis). The two statements discuss different drugs, diseases, and experimental setups; hence there is no connection between them to infer support for the original phrase." -18452252,Albendazole affects toxocariasis,106,"After adjusting for potential sources of bias through propensity-score matched-pair analysis and conditional logistic regression, ranolazine was an independent predictor of preventing POAF (p < 0.0001).",False,"Is the triple 'Albendazole affects toxocariasis' supported by the sentence: 'After adjusting for potential sources of bias through propensity-score matched-pair analysis and conditional logistic regression, ranolazine was an independent predictor of preventing POAF (p < 0.0001).'?","No, the statement does not provide any direct or indirect support for the phrase ""Albendazole affects toxocariasis"". The two statements discuss different topics: ranolazine's effect on preventing postoperative atrial fibrillation (POAF) in one case and albendazole's effect on toxocariasis in another case. The methods used in the study on ranolazine do not relate to albendazole or its effects on toxocariasis. + The two statements belong to different clinical contexts (asthma vs pain management) and do not share any common elements that could be used to infer support for one from the other. Therefore, it is not appropriate to draw any conclusions about ibuprofen preventing pain based on the given statement about prednisolone and asthma." +8584177,Ibuprofen prevents patent ductus arteriosus,168,Reversibility with prednisolone is rarely seen in COPD.,False,"'Does the phrase ""Ibuprofen prevents patent ductus arteriosus"" receive at least indirect support from the statement: ""Reversibility with prednisolone is rarely seen in COPD.""?","No, the statement ""Reversibility with prednisolone is rarely seen in COPD"" does not provide indirect support for the phrase ""Ibuprofen prevents patent ductus arteriosus."" + The two statements discuss different subjects - one refers to Ibuprofen preventing patent ductus arteriosus in infants and the other refers to the reversibility of COPD (Chronic Obstructive Pulmonary Disease) with prednisolone in adults. Patent ductus arteriosus is a congenital heart defect in infants while COPD is a progressive lung disease in adults. The drugs (Ibuprofen and prednisolone) and their effects on different conditions (patent ductus arteriosus and COPD) do not share enough commonality for one statement to indirectly support the other." +7843138,Ibuprofen prevents Alzheimer disease,169,"In spite of the fact that prednisolone-based treatment of pemphigus patients has proved to be effective in controlling the disease, some undesirable effects associated with this form of treatment have prompted investigation into other therapeutic approaches.",False,"'Does the phrase ""Ibuprofen prevents Alzheimer disease"" receive at least indirect support from the statement: ""In spite of the fact that prednisolone-based treatment of pemphigus patients has proved to be effective in controlling the disease, some undesirable effects associated with this form of treatment have prompted investigation into other therapeutic approaches.""?","No, the statement does not provide indirect support for the claim that ibuprofen prevents Alzheimer disease. - To further elaborate on why there is no indirect support between these two statements: + The statement discusses prednisolone-based treatment for pemphigus patients and mentions that undesirable effects have led to investigations into other therapeutic approaches. This information is not related to ibuprofen or its potential effects on Alzheimer disease prevention. Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) commonly used for pain relief, fever reduction, and inflammation; it is not typically associated with Alzheimer disease prevention in medical literature. - 1) Different drugs: Ranolazine is not related to albendazole in terms of chemical structure or therapeutic class; therefore, any conclusions drawn from one drug would not necessarily apply to another drug without additional evidence supporting such an association. + To establish indirect support for the claim that ibuprofen prevents Alzheimer disease, one would need information connecting ibuprofen usage to reduced risk or delayed onset of Alzheimer disease. The statement provided does not contain such information; therefore, it does not indirectly support the claim in question." +15342704,Ibuprofen exacerbates injury,170,One reason for the good clinical effects of prednisolone in RA could be a down-regulation of adhesion and phagocytosis receptors on monocytes.,False,"'Does the phrase ""Ibuprofen exacerbates injury"" receive at least indirect support from the statement: ""One reason for the good clinical effects of prednisolone in RA could be a down-regulation of adhesion and phagocytosis receptors on monocytes.""?","No, the statement ""One reason for the good clinical effects of prednisolone in RA could be a down-regulation of adhesion and phagocytosis receptors on monocytes"" does not provide indirect support for the phrase ""Ibuprofen exacerbates injury."" - 2) Different conditions: The study focuses on ranolazine preventing POAF in patients undergoing cardiac surgery while albendazole is used for treating parasitic infections such as toxocariasis; hence, there is no clear link between these two medical conditions that would allow for indirect inferences based on these statements alone." -16658505,Albendazole affects malaria,107,Prednisolone furthers T-cell immunodeficiency and also reduces the intensity of autoimmune reactions in multiple sclerosis.,False,Is the triple 'Albendazole affects malaria' supported by the sentence: 'Prednisolone furthers T-cell immunodeficiency and also reduces the intensity of autoimmune reactions in multiple sclerosis.'?,"No, the statement does not provide indirect support for the phrase ""Albendazole affects malaria."" The two statements discuss different drugs (Albendazole vs Prednisolone) and their respective effects on unrelated conditions (malaria vs T-cell immunodeficiency and autoimmune reactions in multiple sclerosis). There is no connection between these two distinct pharmacological agents and their effects on separate health issues that would allow for indirect inference regarding Albendazole's impact on malaria." -13946207,Albendazole affects helminthiasis,108,[Pharmacokinetics of prednisolone in adrenal insufficiency ].,False,Is the triple 'Albendazole affects helminthiasis' supported by the sentence: '[Pharmacokinetics of prednisolone in adrenal insufficiency ].'?,"No, the statement ""Pharmacokinetics of prednisolone in adrenal insufficiency"" does not provide any direct or indirect support for the phrase ""Albendazole affects helminthiasis."" The two statements discuss different topics: one is about pharmacokinetics (the process in which a drug is absorbed, distributed, metabolized, and excreted) of prednisolone in adrenal insufficiency, while the other refers to albendazole's effect on helminthiasis (a parasitic infection caused by helminths). + The statement is discussing prednisolone, a corticosteroid drug, and its potential mechanisms in treating rheumatoid arthritis (RA). It suggests that prednisolone might have beneficial effects by down-regulating adhesion and phagocytosis receptors on monocytes, which are types of white blood cells involved in immune responses. - To further elaborate on my response, let me provide some context for both concepts: + Ibuprofen, on the other hand, is a non-steroidal anti-inflammatory drug (NSAID) used for pain relief, fever reduction, and inflammation reduction. The statement does not mention ibuprofen or provide any information about its effects on injury or healing. Therefore, it does not indirectly support the idea that ibuprofen exacerbates injury. - 1. Pharmacokinetics: This term refers to how an organism handles a drug in terms of absorption, distribution, metabolism, and excretion (ADME). The statement in question refers specifically to prednisolone in adrenal insufficiency; however, it does not provide any information about albendazole or helminthiasis that would support their connection. + It is important to note that while some medications can have adverse effects that might" +20007370,Ibuprofen predisposes cerebral palsy,171,OBJECTIVE: To appraise the adjunctive role of prednisolone (PN) in pulmonary tuberculosis (PTB) with toxic reactions.,False,"'Does the phrase ""Ibuprofen predisposes cerebral palsy"" receive at least indirect support from the statement: ""OBJECTIVE: To appraise the adjunctive role of prednisolone (PN) in pulmonary tuberculosis (PTB) with toxic reactions.""?","No, the statement does not provide indirect support for the phrase ""Ibuprofen predisposes cerebral palsy."" The objective of the study is to evaluate the adjunctive role of prednisolone in pulmonary tuberculosis and its toxic reactions. This study has no direct or indirect relation to ibuprofen or cerebral palsy." +14332005,Ibuprofen predisposes bronchopulmonary dysplasia,172,"A significant reduction of survival was found with the presence of permanent visual loss vs absence (p = 0.04), in patients who required more than 10 mg/d of glucocorticoid (p < 0.001) at 6 months treatment and in patients treated with prednisone (vs prednisolone) (p < 0.01).",False,"'Does the phrase ""Ibuprofen predisposes bronchopulmonary dysplasia"" receive at least indirect support from the statement: ""A significant reduction of survival was found with the presence of permanent visual loss vs absence (p = 0.04), in patients who required more than 10 mg/d of glucocorticoid (p < 0.001) at 6 months treatment and in patients treated with prednisone (vs prednisolone) (p < 0.01).""?","No, the statement does not provide indirect support for the phrase ""Ibuprofen predisposes bronchopulmonary dysplasia."" The statement discusses factors associated with reduced survival in patients treated for certain conditions, including higher doses of glucocorticoids and specific types of glucocorticoids (prednisone vs prednisolone). Ibuprofen is not mentioned in the statement, nor is bronchopulmonary dysplasia. Therefore, there is no connection that can be inferred between ibuprofen use and bronchopulmonary dysplasia from this statement." +14294004,Ibuprofen predisposes Alzheimer disease,173,"Fourteen patients developed hyperglycemia during induction therapy of acute lymphoblastic leukemia with L-asparaginase, prednisolone, vincristine and daunorubicin.",False,"'Does the phrase ""Ibuprofen predisposes Alzheimer disease"" receive at least indirect support from the statement: ""Fourteen patients developed hyperglycemia during induction therapy of acute lymphoblastic leukemia with L-asparaginase, prednisolone, vincristine and daunorubicin.""?","No, the statement does not provide indirect support for the phrase ""Ibuprofen predisposes Alzheimer disease."" The statement discusses patients who developed hyperglycemia during induction therapy for acute lymphoblastic leukemia using certain drugs, none of which include ibuprofen or any other non-steroidal anti-inflammatory drugs (NSAIDs) like ibuprofen. To provide indirect support for the original phrase, there would need to be some connection between ibuprofen use and Alzheimer disease risk, which is not suggested by this statement." +14085648,Ibuprofen predisposes injury,174,A 66-year-old man was treated for IgD (lambda) multiple myeloma with 2mg/day melphalan and 20mg/day prednisolone.,False,"'Does the phrase ""Ibuprofen predisposes injury"" receive at least indirect support from the statement: ""A 66-year-old man was treated for IgD (lambda) multiple myeloma with 2mg/day melphalan and 20mg/day prednisolone.""?","No, the statement does not provide indirect support for the phrase ""Ibuprofen predisposes injury."" The statement discusses a 66-year-old man being treated for multiple myeloma using melphalan and prednisolone, without any mention of ibuprofen use or injury predisposition. Therefore, there is no basis in this statement for such an inference." +12673407,Ibuprofen predisposes bone fracture,175,"Moreover, after recent findings regarding the presence of endogenous prednisolone in the urine of more popular breeds, particular attention was given to analysis of the presence of prednisolone and prednisone, as well.",False,"'Does the phrase ""Ibuprofen predisposes bone fracture"" receive at least indirect support from the statement: ""Moreover, after recent findings regarding the presence of endogenous prednisolone in the urine of more popular breeds, particular attention was given to analysis of the presence of prednisolone and prednisone, as well.""?","No, the statement does not provide indirect support for the phrase ""Ibuprofen predisposes bone fracture"". The passage discusses an analysis of prednisolone and prednisone in urine samples of popular dog breeds but does not mention ibuprofen or bone fractures at all. In order for it to provide indirect support for the claim about ibuprofen predisposing bone fractures, there should be some connection between prednisolone/prednisone, ibuprofen, and bone fractures; however, no such connection is evident in the statement provided." +17604344,Ivabradine related to diastolic heart failure,176,"Of 10 mg of prednisone given orally to 5 normal subjects, 69+/-5% was absorbed and converted to peripheral plasma prednisolone within 8 h.",False,"'Does the phrase ""Ivabradine related to diastolic heart failure"" receive at least indirect support from the statement: ""Of 10 mg of prednisone given orally to 5 normal subjects, 69+/-5% was absorbed and converted to peripheral plasma prednisolone within 8 h.""?","No, the statement does not provide any direct or indirect support for the phrase ""Ivabradine related to diastolic heart failure"". The statement discusses the absorption and conversion of prednisone in normal subjects, which has no explicit or implicit connection to ivabradine or diastolic heart failure. Ivabradine is a medication used primarily for heart rate control in conditions like chronic heart failure, but it is not specifically associated with diastolic heart failure in the provided statement." +19228519,Ivabradine causes atrial fibrillation,177,"As in humans, prednisolone was partly converted to prednisone in the rabbit.",False,"'Does the phrase ""Ivabradine causes atrial fibrillation"" receive at least indirect support from the statement: ""As in humans, prednisolone was partly converted to prednisone in the rabbit.""?","No, the statement does not provide indirect support for the phrase ""Ivabradine causes atrial fibrillation."" The two statements discuss different substances (prednisolone/prednisone vs ivabradine) and do not make any connection between those substances that would suggest an effect on atrial fibrillation risk. - 2. Albendazole affects helminthiasis: Albend" -11239060,Albendazole affects filariasis,109,It is concluded that VAP is effective therapy in AIL.,False,Is the triple 'Albendazole affects filariasis' supported by the sentence: 'It is concluded that VAP is effective therapy in AIL.'?,"No, the statement ""It is concluded that VAP is effective therapy in AIL"" does not provide indirect support for the phrase ""Albendazole affects filariasis."" + The statement ""As in humans, prednisolone was partly converted to prednisone in the rabbit"" pertains to drug metabolism in different species, specifically how prednisolone is metabolized into prednisone in both humans and rabbits. This has no bearing on ivabradine or its potential effects on atrial fibrillation risk. - The conclusion that VAP (presumably referring to a specific treatment regimen) is effective therapy in AIL (Adult Intestinal Loiasis) does not necessarily imply any connection to albendazole or its effects on filariasis. Filariasis is a parasitic disease caused by nematode worms, while Loiasis is caused by another species of nematode worm. Although both conditions can be treated with various anthelmintic drugs (including albendazole), they represent distinct clinical entities. + It is important to critically evaluate each statement in isolation and in relation to the specific claim being made. Extraneous information that does not pertain to the claim at hand should be disregarded in order to maintain accuracy in interpretation." +20784958,Ivabradine affects atrial fibrillation,178,"Given the close resemblance of the ring A structure of prednisolone and prednisone on the one hand, and of androstadienedione on the other, the transformation of cortisol and cortisone into prednisolone and prednisone in cattle faeces was evaluated.",False,"'Does the phrase ""Ivabradine affects atrial fibrillation"" receive at least indirect support from the statement: ""Given the close resemblance of the ring A structure of prednisolone and prednisone on the one hand, and of androstadienedione on the other, the transformation of cortisol and cortisone into prednisolone and prednisone in cattle faeces was evaluated.""?","No, the statement does not provide any indirect support for the phrase ""Ivabradine affects atrial fibrillation."" The statement discusses the transformation of cortisol and cortisone into prednisolone and prednisone in cattle faeces, which is unrelated to ivabradine and atrial fibrillation. Ivabradine is a medication used to treat heart failure and certain types of irregular heartbeats (not including atrial fibrillation), while atrial fibrillation is an abnormal heart rhythm characterized by rapid and irregular beating of the atria (the heart's upper chambers). The two subjects are not connected in any meaningful way within the context of the provided statement." +20520107,Ivabradine affects mitral valve stenosis,179,The data indicate that prednisone is extensively metabolized to prednisolone before it clears the splanchnic circulation and the formation prednisone by oxidation of the 11-hydorxyl group of prednisolone appears to occur mainly in peripheral tissues.,False,"'Does the phrase ""Ivabradine affects mitral valve stenosis"" receive at least indirect support from the statement: ""The data indicate that prednisone is extensively metabolized to prednisolone before it clears the splanchnic circulation and the formation prednisone by oxidation of the 11-hydorxyl group of prednisolone appears to occur mainly in peripheral tissues.""?","No, the statement does not provide any indirect support for the claim that ""Ivabradine affects mitral valve stenosis."" The statement discusses the metabolism of prednisone into prednisolone in the splanchnic circulation and its further oxidation in peripheral tissues, which is unrelated to Ivabradine or mitral valve stenosis. Ivabradine is a medication used for heart failure and angina pectoris treatment, having no known direct impact on mitral valve stenosis." +20004006,Ivabradine affects diastolic heart failure,180,CONCLUSION: Dexamethasone or prednisolone were the easiest to induce steroid glaucoma when the patients had long-term use of steroid eyedrops.,False,"'Does the phrase ""Ivabradine affects diastolic heart failure"" receive at least indirect support from the statement: ""CONCLUSION: Dexamethasone or prednisolone were the easiest to induce steroid glaucoma when the patients had long-term use of steroid eyedrops.""?","No, the statement does not provide indirect support for the phrase ""Ivabradine affects diastolic heart failure."" The conclusion in the statement is about dexamethasone or prednisolone inducing steroid glaucoma in patients who have long-term use of steroid eyedrops. Ivabradine is not mentioned in the statement at all, let alone in relation to diastolic heart failure. Therefore, there is no basis for inferring any connection between ivabradine and diastolic heart failure from this statement." +15323309,Ivabradine affects cardiovascular disorder,181,"Among 121 CK-analogs studied, CK-17, CK-101A and CK103A have been identified as promising anti-inflammatory agents as potent as prednisolone in inhibiting lens proteins-induced inflammation and twice as potent as prednisolone in inhibiting endotoxin-and IL-1-induced uveitis.",False,"'Does the phrase ""Ivabradine affects cardiovascular disorder"" receive at least indirect support from the statement: ""Among 121 CK-analogs studied, CK-17, CK-101A and CK103A have been identified as promising anti-inflammatory agents as potent as prednisolone in inhibiting lens proteins-induced inflammation and twice as potent as prednisolone in inhibiting endotoxin-and IL-1-induced uveitis.""?","No, the statement does not provide indirect support for the phrase ""Ivabradine affects cardiovascular disorder"". The statement discusses the anti-inflammatory properties of certain CK-analogs (CK-17, CK-101A, and CK-103A) in inhibiting lens proteins-induced inflammation and uveitis. Ivabradine is not mentioned in this statement; therefore, it does not offer any evidence or implications regarding Ivabradine's effects on cardiovascular disorders." +15323306,Ivabradine affects coronary artery disorder,182,Light and electron microscopy of prednisolone-induced nephropathy in rabbits.,False,"'Does the phrase ""Ivabradine affects coronary artery disorder"" receive at least indirect support from the statement: ""Light and electron microscopy of prednisolone-induced nephropathy in rabbits.""?","No, the statement ""Light and electron microscopy of prednisolone-induced nephropathy in rabbits"" does not provide indirect support for the phrase ""Ivabradine affects coronary artery disorder"". - Therefore, without additional information linking albendazole, filariasis, and VAP in AIL treatment, it is not possible to infer any supportive relationship between the two statements provided." -24729219,Albendazole disrupts helminthiasis,110,A thermographic assessment of three intra-articular prednisolone analogues given in rheumatoid synovitis.,False,Is the triple 'Albendazole disrupts helminthiasis' supported by the sentence: 'A thermographic assessment of three intra-articular prednisolone analogues given in rheumatoid synovitis.'?,"No, the statement ""A thermographic assessment of three intra-articular prednisolone analogues given in rheumatoid synovitis"" does not provide indirect support for the phrase ""Albendazole disrupts helminthiasis."" + The statement in question is related to nephropathy in rabbits induced by prednisolone, which is an entirely different physiological system and condition from coronary artery disorder in humans or animals. Nephropathy refers to kidney disease, while Ivabradine is a medication used to treat certain heart conditions in humans. Therefore, there is no reasonable connection between these two pieces of information." +19514713,Ivabradine disrupts atrial fibrillation,183,The behavior results showed that exposure to prednisolone resulted in decreased autonomic activity and low sensitivity to light.,False,"'Does the phrase ""Ivabradine disrupts atrial fibrillation"" receive at least indirect support from the statement: ""The behavior results showed that exposure to prednisolone resulted in decreased autonomic activity and low sensitivity to light.""?","No, the statement does not provide indirect support for the phrase ""Ivabradine disrupts atrial fibrillation."" The statement mentions exposure to prednisolone and its effects on autonomic activity and light sensitivity, but it does not mention ivabradine or atrial fibrillation at all. Therefore, there is no connection that can be inferred between the two statements. Ivabradine is a medication used for heart failure and angina pectoris treatment, while prednisolone is a corticosteroid used for its anti-inflammatory and immunosuppressive effects. Atrial fibrillation is an irregular heart rhythm disturbance of the atria (the heart's upper chambers). Since there is no overlap in these concepts within the provided statement, no indirect support can be established." +17909104,Ivabradine disrupts coronary artery disorder,184,We therefore advocate for increased clinical alertness towards prednisolone-induced adrenal insufficiency in RTx patients and thus their potential need of rescue GC supplementation during stress.,False,"'Does the phrase ""Ivabradine disrupts coronary artery disorder"" receive at least indirect support from the statement: ""We therefore advocate for increased clinical alertness towards prednisolone-induced adrenal insufficiency in RTx patients and thus their potential need of rescue GC supplementation during stress.""?","No, the statement does not provide indirect support for the phrase ""Ivabradine disrupts coronary artery disorder"". - The statement is about a thermographic assessment of three intra-articular prednisolone analogues in rheumatoid synovitis, which is an evaluation of arthritis treatment methods using thermal imaging. This has no direct relation to albendazole, which is an antiparasitic medication used primarily for treating intestinal worm infections (helminthiasis). The two statements belong to different medical fields (rheumatology and parasitology respectively) without any overlap in their subject matter or implications." -16658503,Albendazole disrupts malaria,111,The effect of small doses of prednisolone on the incidence of subcutaneous sarcomas induced by 3-methylcholanthrene in virgin female Swiss mice.,False,Is the triple 'Albendazole disrupts malaria' supported by the sentence: 'The effect of small doses of prednisolone on the incidence of subcutaneous sarcomas induced by 3-methylcholanthrene in virgin female Swiss mice.'?,"No, the statement does not provide any indirect support for the phrase ""Albendazole disrupts malaria."" The statement discusses the effect of small doses of prednisolone on subcutaneous sarcomas induced by 3-methylcholanthrene in female Swiss mice. This has no relation to albendazole or malaria." -13637338,Albendazole disrupts Hookworm Infections,112,[Effects of chromocarb diethylamine and prednisolone in experimental uveitis induced by clove oil in rabbits].,False,Is the triple 'Albendazole disrupts Hookworm Infections' supported by the sentence: '[Effects of chromocarb diethylamine and prednisolone in experimental uveitis induced by clove oil in rabbits].'?,"No, the statement does not provide indirect support for the phrase ""Albendazole disrupts Hookworm Infections."" The title in question discusses the effects of chromocarb diethylamine and prednisolone in experimental uveitis induced by clove oil in rabbits. There is no mention or implication of albendazole, hookworm infections, or any related biological processes in this title. Therefore, it does not offer any relevant context or evidence that could indirectly support the claim about albendazole disrupting hookworm infections." -15248433,Albendazole prevents filariasis,113,[Effect of prednisolone and heparin on circulating T- and B-lymphocytes in glomerulonephritis and systemic lupus erythematosus].,False,Is the triple 'Albendazole prevents filariasis' supported by the sentence: '[Effect of prednisolone and heparin on circulating T- and B-lymphocytes in glomerulonephritis and systemic lupus erythematosus].'?,"No, the statement does not provide any direct or indirect support for the claim that Albendazole prevents filariasis. The provided statement discusses the effect of prednisolone and heparin on circulating T- and B-lymphocytes in glomerulonephritis and systemic lupus erythematosus, which is unrelated to Albendazole or filariasis prevention. + The statement is discussing prednisolone-induced adrenal insufficiency in renal transplant (RTx) patients and the potential need for rescue glucocorticoid (GC) supplementation during stressful situations. This is completely unrelated to Ivabradine, which is a medication used to treat heart failure and reduce heart rate. Ivabradine does not have any known effects on coronary artery disorders that would disrupt them. Therefore, there is no connection between the two statements." +17822394,Ivabradine prevents atrial fibrillation,185,Zeaxanthin (50 mg/kg/day) or prednisolone (5 mg/kg/day) was orally administered for 14 days before induction of ulcerative colitis.,False,"'Does the phrase ""Ivabradine prevents atrial fibrillation"" receive at least indirect support from the statement: ""Zeaxanthin (50 mg/kg/day) or prednisolone (5 mg/kg/day) was orally administered for 14 days before induction of ulcerative colitis.""?","No, the statement does not provide indirect support for the claim that ""Ivabradine prevents atrial fibrillation."" The substances mentioned in the statement, zeaxanthin and prednisolone, have no direct relation to ivabradine or atrial fibrillation. Furthermore, the context of ulcerative colitis induction is unrelated to either ivabradine or atrial fibrillation. Therefore, there is no reasonable basis for inferring that ivabradine prevents atrial fibrillation based on the given statement." +10817471,Ivabradine prevents Tachycardia,186,"OBJECTIVE: We want to show that an intralesional injection of prednisolone into the proximal nail fold may produce dorsal pain, dyspnoea and headaches within the 2 min following the injection and to explain the pathophysiology of his condition.",False,"'Does the phrase ""Ivabradine prevents Tachycardia"" receive at least indirect support from the statement: ""OBJECTIVE: We want to show that an intralesional injection of prednisolone into the proximal nail fold may produce dorsal pain, dyspnoea and headaches within the 2 min following the injection and to explain the pathophysiology of his condition.""?","No, the statement does not provide indirect support for the phrase ""Ivabradine prevents Tachycardia."" The objective of the study mentioned in the statement is focused on demonstrating the effects of an intralesional injection of prednisolone into the proximal nail fold and explaining the resulting condition's pathophysiology. It does not involve Ivabradine or its potential in preventing tachycardia (rapid heart rate). Therefore, it does not offer any relevant evidence or implications concerning Ivabradine's effects on tachycardia prevention." +19153602,Ivabradine predisposes atrial fibrillation,187,[A case of nephrotic syndrome with abnormally high level of protein C induced by prednisolone].,False,"'Does the phrase ""Ivabradine predisposes atrial fibrillation"" receive at least indirect support from the statement: ""[A case of nephrotic syndrome with abnormally high level of protein C induced by prednisolone].""?","No, the statement does not provide indirect support for the phrase ""Ivabradine predisposes atrial fibrillation."" The statement is about a case of nephrotic syndrome induced by prednisolone, which has no direct relevance to Ivabradine or atrial fibrillation. Ivabradine is a medication used primarily for heart failure and angina pectoris, not atrial fibrillation or nephrotic syndrome. Therefore, there is no reasonable connection between these two statements based on the information provided." +15385004,Cefixime affects chronic bronchitis,188,It is concluded that six or more cycles of COPP chemotherapy for advanced Hodgkin's disease in men leads to permanent sterility.,False,"'Does the phrase ""Cefixime affects chronic bronchitis"" receive at least indirect support from the statement: ""It is concluded that six or more cycles of COPP chemotherapy for advanced Hodgkin's disease in men leads to permanent sterility.""?","No, the statement does not provide indirect support for the phrase ""Cefixime affects chronic bronchitis."" The conclusion drawn in the statement is about the impact of COPP (Cyclophosphamide, Oncovin (vincristine), Procarbazine, Prednisone) chemotherapy on male sterility in Hodgkin's disease patients. It does not mention or imply any connection to Cefixime or chronic bronchitis. Cefixime is an antibiotic used primarily for treating respiratory tract infections while chronic bronchitis is an inflammatory disease of the airways in the lungs. The statement provided is unrelated to these subjects." +15252860,Cefixime affects gonorrhea,189,The erythroderma improved generally as a result of systemic prednisolone treatment.,False,"'Does the phrase ""Cefixime affects gonorrhea"" receive at least indirect support from the statement: ""The erythroderma improved generally as a result of systemic prednisolone treatment.""?","No, the statement ""The erythroderma improved generally as a result of systemic prednisolone treatment"" does not provide indirect support for the phrase ""Cefixime affects gonorrhea."" - To further clarify, filariasis is caused by parasitic roundworms that belong to the Filarioidea family; it is not related to glomerulonephritis (inflammation in kidney) or systemic lupus erythematosus (autoimmune disorder). Albendazole is an anthelmintic drug used in treating filariasis; however, it is not mentioned in the given statement at all. + The improvement of erythroderma (a type of skin rash) due to systemic prednisolone treatment is not related to Cefixime's effect on gonorrhea (a sexually transmitted infection). Prednisolone is a corticosteroid used for treating various inflammatory conditions including erythroderma; it has no direct effect on gonorrhea or Cefixime. - In conclusion, there is no connection between the statement provided and the claim that Albendazole prevents filariasis, making it invalid to infer any level of support from one to another." -13732336,Albendazole prevents helminthiasis,114,[Effects of prednisolone on thyroidal-123I uptake in subacute thyroiditis].,False,Is the triple 'Albendazole prevents helminthiasis' supported by the sentence: '[Effects of prednisolone on thyroidal-123I uptake in subacute thyroiditis].'?,"No, the statement does not provide any direct or indirect support for the claim that Albendazole prevents helminthiasis. The statement is about prednisolone's effects on thyroidal-123I uptake in subacute thyroiditis, which is unrelated to Albendazole or helminthiasis. Helminthiasis is a condition caused by parasitic worms, and Albendazole is an anti-parasitic drug used to treat such conditions. However, there is no mention or implication of this in the provided statement." -15316470,Ibuprofen subclass of 2-Hydroxyibuprofen,115,"Blood Eosinophil Depletion with Mepolizumab, Benralizumab and Prednisolone in Eosinophilic Asthma.",False,"Is the triple 'Ibuprofen subclass of 2-Hydroxyibuprofen' supported by the sentence: 'Blood Eosinophil Depletion with Mepolizumab, Benralizumab and Prednisolone in Eosinophilic Asthma.'?","No, the phrase ""Ibuprofen subclass of 2-Hydroxyibuprofen"" does not receive indirect support from the statement: ""Blood Eosinophil Depletion with Mepolizumab, Benralizumab and Prednisolone in Eosinophilic Asthma."" + Cefixime is an antibiotic used for treating infections caused by certain bacteria such as gonorrhea but there is no mention of its use in this statement nor any correlation between its use and the improvement of erythroderma or gonorrhea. Therefore, it does not provide indirect support for the given phrase." +18811968,Cefixime prevents otitis media,190,CONTACT DERMATITIS DUE TO TOPICAL HYDROCORTISONE AND PREDNISOLONE.,False,"'Does the phrase ""Cefixime prevents otitis media"" receive at least indirect support from the statement: ""CONTACT DERMATITIS DUE TO TOPICAL HYDROCORTISONE AND PREDNISOLONE.""?","No, the statement ""CONTACT DERMATITIS DUE TO TOPICAL HYDROCORTISONE AND PREDNISOLONE"" does not provide indirect support for the claim that ""Cefixime prevents otitis media."" - The statement provided primarily discusses blood eosinophil depletion in eosinophilic asthma using three specific medications: mepolizumab, benralizumab, and prednisolone. Ibuprofen is not mentioned in the statement nor is it related to any of these medications in terms of being a subclass. + The statement about contact dermatitis refers to skin reactions caused by topical application of hydrocortisone and prednisolone, which are corticosteroids used to reduce inflammation. This statement is not related to Cefixime, an antibiotic used to treat infections caused by bacteria. - Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) that is commonly used for pain relief and fever reduction. 2-Hydroxyibuprofen is one of the major metabolites formed in vivo when ibuprofen is metabolized in humans by cytochrome P450 enzymes (primarily CYP2C9). Thus, 2-Hydroxyibuprofen is not" -16265626,Ibuprofen related to Arthralgia,116,[Prednisolone and aspirin combination therapy in habitual abortion with autoantibodies].,False,Is the triple 'Ibuprofen related to Arthralgia' supported by the sentence: '[Prednisolone and aspirin combination therapy in habitual abortion with autoantibodies].'?,"No, the statement ""Prednisolone and aspirin combination therapy in habitual abortion with autoantibodies"" does not provide indirect support for the phrase ""Ibuprofen related to Arthralgia."" The statement discusses prednisolone and aspirin combination therapy in relation to habitual abortion in patients who have autoantibodies, which does not mention ibuprofen or arthralgia (joint pain). + Furthermore, otitis media is an inflammation or infection of the middle ear, which is not directly related to contact dermatitis or the use of corticosteroids. - The statement does discuss aspirin, which is another non-steroidal anti-inflammatory drug (NSAID) like ibuprofen; however, it does not provide evidence for an association between ibuprofen specifically and arthralgia. + Therefore, there is no logical connection between these two statements that would allow for indirect support of the claim about Cefixime preventing otitis media." +17748395,Trimetazidine related to diabetic kidney disease,191,[Pulmonary tuberculosis due to prednisolone].,False,"'Does the phrase ""Trimetazidine related to diabetic kidney disease"" receive at least indirect support from the statement: ""[Pulmonary tuberculosis due to prednisolone].""?","No, the statement ""Pulmonary tuberculosis due to prednisolone"" does not provide indirect support for the phrase ""Trimetazidine related to diabetic kidney disease."" This is because these two statements discuss entirely different medical conditions (pulmonary tuberculosis and diabetic kidney disease) and medications (prednisolone and trimetazidine). There is no connection between pulmonary tuberculosis, prednisolone, trimetazidine, and diabetic kidney disease in these statements that would allow for indirect support." +22426756,Trimetazidine affects diabetic kidney disease,192,"Rats were treated with a leukotriene synthesis inhibitor (PF-5901), a leukotriene B4 receptor antagonist (SC-41930), an IL-1 receptor antagonist or a corticosteroid (prednisolone) prior to induction of colitis.",False,"'Does the phrase ""Trimetazidine affects diabetic kidney disease"" receive at least indirect support from the statement: ""Rats were treated with a leukotriene synthesis inhibitor (PF-5901), a leukotriene B4 receptor antagonist (SC-41930), an IL-1 receptor antagonist or a corticosteroid (prednisolone) prior to induction of colitis.""?","No, the statement does not provide indirect support for the claim that Trimetazidine affects diabetic kidney disease. The provided statement describes an experiment where rats were treated with various substances before inducing colitis. Trimetazidine is not among these substances, nor is there any mention of kidney disease or diabetes in the statement. Therefore, it does not offer any evidence or support for the claim about Trimetazidine's effect on diabetic kidney disease." +21297588,Trimetazidine affects Cardiotoxicity,193,"PURPOSE: To investigate the relationship between vitamin E deficiency and prednisolone-induced cataract formation, long-term examination of lens changes was performed in rats under the condition of vitamin E deficiency or supplementation and administration of prednisolone.",False,"'Does the phrase ""Trimetazidine affects Cardiotoxicity"" receive at least indirect support from the statement: ""PURPOSE: To investigate the relationship between vitamin E deficiency and prednisolone-induced cataract formation, long-term examination of lens changes was performed in rats under the condition of vitamin E deficiency or supplementation and administration of prednisolone.""?","No, the statement does not provide any direct or indirect support for the claim that Trimetazidine affects Cardiotoxicity. The purpose of the study as stated is to investigate the relationship between vitamin E deficiency and prednisolone-induced cataract formation in rats. There is no mention of Trimetazidine in the statement, nor does it discuss cardiotoxicity or any related cardiovascular effects. Therefore, it does not contribute any evidence towards the claim about Trimetazidine's effects on cardiotoxicity." +19164679,Trimetazidine affects cardiovascular disorder,194,"In inactive SLE induced by prednisolone therapy, the invariant Valpha24JalphaQ TCR could be detected in DN Valpha24+ T cells from all the patients and dominated in most of the patients.",False,"'Does the phrase ""Trimetazidine affects cardiovascular disorder"" receive at least indirect support from the statement: ""In inactive SLE induced by prednisolone therapy, the invariant Valpha24JalphaQ TCR could be detected in DN Valpha24+ T cells from all the patients and dominated in most of the patients.""?","No, the statement does not provide any direct or indirect support for the phrase ""Trimetazidine affects cardiovascular disorder."" The statement discusses the presence and dominance of invariant Valpha24JalphaQ TCR in DN Valpha24+ T cells in patients receiving prednisolone therapy for inactive Systemic Lupus Erythematosus (SLE). This has no relation to Trimetazidine or cardiovascular disorders. Trimetazidine is a medication used primarily in treating angina pectoris, which is chest pain caused by reduced blood flow to the heart muscle. Cardiovascular disorders encompass a wide range of conditions affecting the heart and blood vessels; therefore, further specific evidence would be required to make any connection between Trimetazidine and these disorders." +18547788,Trimetazidine prevents Cardiotoxicity,195,"Interleukin-1 (IL-1) blockers, CK 127 and CK 129, were found to inhibit IL-1-induced posterior uveitis very effectively at 3-10 mg/kg i.p. and were more potent than prednisolone which required at least 20 mg/kg i.p. to achieve the same level of anti-uveitis action.",False,"'Does the phrase ""Trimetazidine prevents Cardiotoxicity"" receive at least indirect support from the statement: ""Interleukin-1 (IL-1) blockers, CK 127 and CK 129, were found to inhibit IL-1-induced posterior uveitis very effectively at 3-10 mg/kg i.p. and were more potent than prednisolone which required at least 20 mg/kg i.p. to achieve the same level of anti-uveitis action.""?","No, the statement does not provide indirect support for the phrase ""Trimetazidine prevents Cardiotoxicity"". - It is essential not to make unwarranted conclusions based on insufficient evidence in order to maintain integrity in interpreting research results." -14582794,Ibuprofen related to Pain,117,"To illustrate this, we used an example of cost-effectiveness analysis for docetaxel in combination with prednisolone in metastatic hormone-refractory prostate cancer.",False,"Is the triple 'Ibuprofen related to Pain' supported by the sentence: 'To illustrate this, we used an example of cost-effectiveness analysis for docetaxel in combination with prednisolone in metastatic hormone-refractory prostate cancer.'?","No, the statement does not provide any direct or indirect support for the phrase ""Ibuprofen related to Pain."" The statement discusses a cost-effectiveness analysis for docetaxel in combination with prednisolone in metastatic hormone-refractory prostate cancer. Ibuprofen, which is a non-steroidal anti-inflammatory drug (NSAID) used primarily for relieving pain, inflammation, and fever, is not mentioned in the statement. Therefore, there is no connection between ibuprofen and pain in this context." -11440746,Ibuprofen related to Toothache,118,Prednisolone is associated with a worse bone mineral density in primary adrenal insufficiency.,False,Is the triple 'Ibuprofen related to Toothache' supported by the sentence: 'Prednisolone is associated with a worse bone mineral density in primary adrenal insufficiency.'?,"No, the statement ""Prednisolone is associated with worse bone mineral density in primary adrenal insufficiency"" does not provide indirect support for the phrase ""Ibuprofen related to Toothache."" These two statements discuss different subjects (Prednisolone and bone mineral density vs Ibuprofen and toothache) and do not share any common concepts that would allow for an indirect inference between them. + The statement discusses the effectiveness of Interleukin-1 (IL-1) blockers, CK 127 and CK 129, in inhibiting IL-1-induced posterior uveitis in eye conditions. This is unrelated to Trimetazidine, which is a drug used to treat heart conditions and has not been mentioned in the statement. Therefore, there is no connection or indirect support that can be drawn from this statement regarding Trimetazidine's ability to prevent cardiotoxicity." +13317799,Ranolazine causes atrial fibrillation,196,[A case of hormone-refractory prostate cancer responsive to low-dose prednisolone therapy].,False,"'Does the phrase ""Ranolazine causes atrial fibrillation"" receive at least indirect support from the statement: ""[A case of hormone-refractory prostate cancer responsive to low-dose prednisolone therapy].""?","No, the statement does not provide any indirect support for the claim that ""Ranolazine causes atrial fibrillation."" The statement discusses a case of hormone-refractory prostate cancer that responded to low-dose prednisolone therapy but does not mention Ranolazine or atrial fibrillation at all. Therefore, there is no connection between the two statements that would allow for indirect support of the claim about Ranolazine causing atrial fibrillation." +19314329,Ranolazine affects cardiovascular disorder,197,6 cases of FSGS had poor response to any therapy; 7 cases were responsive to either triple therapy or cyclosporine A plus prednisolone.,False,"'Does the phrase ""Ranolazine affects cardiovascular disorder"" receive at least indirect support from the statement: ""6 cases of FSGS had poor response to any therapy; 7 cases were responsive to either triple therapy or cyclosporine A plus prednisolone.""?","No, the statement does not provide indirect support for the phrase ""Ranolazine affects cardiovascular disorder"". The statement discusses two groups of patients with Focal Segmental Glomerulosclerosis (FSGS) who had different responses to various treatments including triple therapy and cyclosporine A plus prednisolone. Ranolazine, which is primarily used for treating chronic angina, is not mentioned in the statement. Therefore, there is no connection between the drug and the cardiovascular disorder in this context." +19002641,Ranolazine affects atrial fibrillation,198,"From 1983, exacerbation of PIE was recorded three times, on which occasions prednisolone and antibiotics were quite effective.",False,"'Does the phrase ""Ranolazine affects atrial fibrillation"" receive at least indirect support from the statement: ""From 1983, exacerbation of PIE was recorded three times, on which occasions prednisolone and antibiotics were quite effective.""?","No, the statement does not provide indirect support for the phrase ""Ranolazine affects atrial fibrillation."" The statement discusses the exacerbation of PIE (paroxysmal irritable atrial rhythm) and its treatment with prednisolone and antibiotics. Ranolazine is not mentioned in the statement, so there is no connection between it and atrial fibrillation in this context. - However, Ibuprofen is an NSAID (nonsteroidal anti-inflammatory drug) like aspirin and naproxen, which can be used for pain relief including toothaches. Prednisolone is a corticosteroid used primarily for its anti-inflammatory effects in various conditions such as adrenal insufficiency. Although both types of medications have anti-inflammatory properties, they have different mechanisms of action; thus, their effects on the body can vary significantly. + However, it is important to note that Ranolazine is indeed used in clinical practice for treating angina pectoris and chronic stable angina by reducing myocardial oxygen demand through partial fatty acid oxidation inhibition (Belardinelli et al., 2003). Some studies have suggested that it may have antiarrhythmic properties (Chaitman et al., 2004), but there is no direct link between Ranolazine and atrial fibrillation in the statement provided. - Therefore, it is crucial to assess each medication individually based on relevant studies and evidence when discussing their associations with specific health issues such as toothache or bone mineral density changes." -9106384,Ibuprofen related to osteoarthritis,119,CONCLUSIONS: Prednisolone was more effective in inducing response than itraconazole in acute-stage ABPA.,False,Is the triple 'Ibuprofen related to osteoarthritis' supported by the sentence: 'CONCLUSIONS: Prednisolone was more effective in inducing response than itraconazole in acute-stage ABPA.'?,"No, the statement ""Prednisolone was more effective in inducing response than itraconazole in acute-stage ABPA"" does not provide indirect support for the phrase ""Ibuprofen related to osteoarthritis."" The conclusion is about the efficacy comparison between prednisolone and itraconazole for treating acute-stage allergic bronchopulmonary aspergillosis (ABPA). Ibuprofen is not mentioned in the statement, nor is there any connection made between ibuprofen and osteoarthritis in it. + References + Belardinelli L., et al., (2003). Inhibition of fatty acid oxidation by ranolazine prevents ischemia-induced impairment in left ventricular function in" +17881291,Ranolazine affects type 2 diabetes mellitus,199,"A comparative study of the effects of ACTH, hydrocortisone and prednisolone in the hypersensitive reactions produced with the protein components of Hymenolepis nana in albino mice.",False,"'Does the phrase ""Ranolazine affects type 2 diabetes mellitus"" receive at least indirect support from the statement: ""A comparative study of the effects of ACTH, hydrocortisone and prednisolone in the hypersensitive reactions produced with the protein components of Hymenolepis nana in albino mice.""?","No, the statement ""A comparative study of the effects of ACTH, hydrocortisone and prednisolone in the hypersensitive reactions produced with the protein components of Hymenolepis nana in albino mice"" does not provide any direct or indirect support for the phrase ""Ranolazine affects type 2 diabetes mellitus"". - To provide indirect support for ""Ibuprofen related to osteoarthritis,"" one should find evidence that links ibuprofen usage in treating osteoarthritis symptoms or side effects in patients suffering from osteoarthritis. This statement does not offer any such connection, so it cannot be used as indirect evidence for that claim." -8106985,Ibuprofen related to burn,120,"Purpose: The aim of this study was to compare asparaginase-related toxicities in two asparaginase preparations, namely native Escherichia coli L-asparaginase (L-ASP) and pegylated asparaginase (PEG-ASP) in combination with ifosfamide, methotrexate, etoposide, and prednisolone (IMEP) in natural killer (NK)/T-cell lymphoma (NTCL).",False,"Is the triple 'Ibuprofen related to burn' supported by the sentence: 'Purpose: The aim of this study was to compare asparaginase-related toxicities in two asparaginase preparations, namely native Escherichia coli L-asparaginase (L-ASP) and pegylated asparaginase (PEG-ASP) in combination with ifosfamide, methotrexate, etoposide, and prednisolone (IMEP) in natural killer (NK)/T-cell lymphoma (NTCL).'?","No, the statement does not provide any indirect support for the phrase ""Ibuprofen related to burn"". The purpose statement discusses a study comparing toxicities from two asparaginase preparations used in combination therapy for NK/T-cell lymphoma. Ibuprofen is not mentioned in the statement, nor is there any connection made between ibuprofen and burn-related injuries." -13726345,Ibuprofen causes patent ductus arteriosus,121,Prednisolone combined with adjunctive immunosuppression is not superior to prednisolone alone in terms of efficacy and safety in giant cell arteritis: meta-analysis.,False,Is the triple 'Ibuprofen causes patent ductus arteriosus' supported by the sentence: 'Prednisolone combined with adjunctive immunosuppression is not superior to prednisolone alone in terms of efficacy and safety in giant cell arteritis: meta-analysis.'?,"No, the statement does not provide indirect support for the phrase ""Ibuprofen causes patent ductus arteriosus"". The meta-analysis discusses the efficacy and safety of prednisolone combined with adjunctive immunosuppression versus prednisolone alone in treating giant cell arteritis, without mentioning ibuprofen or patent ductus arteriosus. + The statement in question is about a comparative study of the effects of three hormones (ACTH, hydrocortisone, and prednisolone) on hypersensitive reactions in albino mice induced by protein components of Hymenolepis nana, a type of tapeworm. There is no mention of Ranolazine, a medication used to treat chronic angina, nor is there any reference to type 2 diabetes mellitus in this statement. Therefore, it does not contribute to the understanding or validation of the stated phrase about Ranolazine affecting type 2 diabetes mellitus." +16599546,Ranolazine affects atrial fibrillation,200,"Immunosuppressant therapy, such as prednisolone or azathioprine, is considered for exacerbations of highly active glomerulonephritis.",False,"'Does the phrase ""Ranolazine affects atrial fibrillation"" receive at least indirect support from the statement: ""Immunosuppressant therapy, such as prednisolone or azathioprine, is considered for exacerbations of highly active glomerulonephritis.""?","No, the statement does not provide indirect support for the phrase ""Ranolazine affects atrial fibrillation."" The two statements discuss different medical topics - one is about immunosuppressant therapy for glomerulonephritis exacerbations while the other is about Ranolazine affecting atrial fibrillation. There is no connection between these topics that would allow us to infer any support for the effect of Ranolazine on atrial fibrillation from the immunosuppressant therapy statement." +15199166,Ranolazine affects myocardial ischemia,201,"We describe a 57-year-old Caucasian male with anti-MDA5 positive dermatomyositis, that had a 4-month history of progressive dyspnoea requiring oxygen-therapy, scarcely responsive to prednisolone.",False,"'Does the phrase ""Ranolazine affects myocardial ischemia"" receive at least indirect support from the statement: ""We describe a 57-year-old Caucasian male with anti-MDA5 positive dermatomyositis, that had a 4-month history of progressive dyspnoea requiring oxygen-therapy, scarcely responsive to prednisolone.""?","No, the statement does not provide direct or indirect support for the phrase ""Ranolazine affects myocardial ischemia."" The statement describes a case of a patient with dermatomyositis who has been experiencing dyspnea for four months and has not responded well to prednisolone therapy. Ranolazine is not mentioned in this statement, nor is there any information about myocardial ischemia or its potential management with Ranolazine in this specific case. To establish support for the claim that ""Ranolazine affects myocardial ischemia,"" evidence should demonstrate that Ranolazine has been administered in similar clinical scenarios and has led to improvements in myocardial ischemia symptoms or outcomes." +13887428,Ranolazine disrupts atrial fibrillation,202,"After 14 months of treatment one of the patients developed severe, acute exacerbation of the ABPA and was treated with high-dose prednisolone and local steroid.",False,"'Does the phrase ""Ranolazine disrupts atrial fibrillation"" receive at least indirect support from the statement: ""After 14 months of treatment one of the patients developed severe, acute exacerbation of the ABPA and was treated with high-dose prednisolone and local steroid.""?","No, the statement does not provide indirect support for the phrase ""Ranolazine disrupts atrial fibrillation"". The statement discusses a patient who developed an acute exacerbation of Allergic Bronchopulmonary Aspergillosis (ABPA) after 14 months of treatment. The treatment mentioned is high-dose prednisolone and local steroid, which is not related to Ranolazine or atrial fibrillation disruption. Therefore, there is no connection between the two statements that would allow for indirect support of the claim about Ranolazine disrupting atrial fibrillation." +17475563,Ranolazine prevents Angina pectoris,203,"The effect of pretreatment with topical prostaglandin E2, prednisolone and sulphasalazine in experimental colitis has been examined in the rat colon.",False,"'Does the phrase ""Ranolazine prevents Angina pectoris"" receive at least indirect support from the statement: ""The effect of pretreatment with topical prostaglandin E2, prednisolone and sulphasalazine in experimental colitis has been examined in the rat colon.""?","No, the statement does not provide any direct or indirect support for the claim that ""Ranolazine prevents Angina pectoris."" The statement discusses an experiment conducted on rat colons using topical prostaglandin E2, prednisolone, and sulphasalazine, which has no relevance or connection to Ranolazine or Angina pectoris treatment in humans. Angina pectoris is chest pain caused by an inadequate supply of oxygen-rich blood to the heart muscle, while Ranolazine is a medication used for treating chronic angina by reducing the frequency of angina attacks. Therefore, there is no shared context between these two pieces of information that would allow for indirect support of the claim about Ranolazine preventing Angina pectoris." +14751648,Ranolazine prevents myocardial ischemia,204,"Here, we report a case of prednisolone-dependent gastric sarcoidosis that improved after additional azathioprine, and also review the literature concerning the treatment, especially for prednisolone-dependent cases.",False,"'Does the phrase ""Ranolazine prevents myocardial ischemia"" receive at least indirect support from the statement: ""Here, we report a case of prednisolone-dependent gastric sarcoidosis that improved after additional azathioprine, and also review the literature concerning the treatment, especially for prednisolone-dependent cases.""?","No, the statement does not provide indirect support for the phrase ""Ranolazine prevents myocardial ischemia"". The statement discusses a case of prednisolone-dependent gastric sarcoidosis that improved after additional azathioprine treatment and a literature review of treatments for prednisolone-dependent cases. Ranolazine is not mentioned in the statement, nor is there any connection made between its use and prevention of myocardial ischemia." +14280230,Ranolazine prevents atrial fibrillation,205,"METHODS: In 126 adults (33 healthy control subjects, 31 patients with mild asthma, 32 patients with severe asthma, and 30 patients with prednisolone-dependent asthma) parameters of inflammation (peripheral blood eosinophils and neutrophils) and markers of hemostasis (endogenous thrombin potential [ETP], thrombin-antithrombin complex, plasmin-alpha2-antiplasmin complex, plasminogen activator inhibitor type 1 [PAI-1], D-dimer, and von Willebrand factor [vWF]) were measured in plasma.",False,"'Does the phrase ""Ranolazine prevents atrial fibrillation"" receive at least indirect support from the statement: ""METHODS: In 126 adults (33 healthy control subjects, 31 patients with mild asthma, 32 patients with severe asthma, and 30 patients with prednisolone-dependent asthma) parameters of inflammation (peripheral blood eosinophils and neutrophils) and markers of hemostasis (endogenous thrombin potential [ETP], thrombin-antithrombin complex, plasmin-alpha2-antiplasmin complex, plasminogen activator inhibitor type 1 [PAI-1], D-dimer, and von Willebrand factor [vWF]) were measured in plasma.""?","No, the statement does not provide indirect support for the phrase ""Ranolazine prevents atrial fibrillation"". The methods section provided only outlines the parameters of inflammation and markers of hemostasis that were measured in plasma from different subject groups. It does not mention any intervention with Ranolazine nor any outcomes related to atrial fibrillation. Therefore, it is impossible to infer any relationship between Ranolazine and atrial fibrillation prevention based on this information alone." +17988674,Ranolazine predisposes atrial fibrillation,206,Previous studies from our laboratory revealed that coadministration of EP significantly increased the plasma concentration of prednisolone while decreased the level of cotreated prednisone in rats.,False,"'Does the phrase ""Ranolazine predisposes atrial fibrillation"" receive at least indirect support from the statement: ""Previous studies from our laboratory revealed that coadministration of EP significantly increased the plasma concentration of prednisolone while decreased the level of cotreated prednisone in rats.""?","No, the statement does not provide indirect support for the phrase ""Ranolazine predisposes atrial fibrillation."" The statement discusses the effects of coadministration of EP on plasma concentrations of prednisolone and prednisone in rats, which is unrelated to ranolazine's potential predisposition towards atrial fibrillation in humans. - The two statements belong to different medical contexts: one is about ibuprofen potentially causing patent ductus arteriosus (PDA), while another is about prednisolone treatment in giant cell arteritis (GCA). There is no overlap between these subjects in terms of pharmacological agents discussed (ibuprofen vs prednisolone) or medical conditions addressed (PDA vs GCA). Therefore, it is inappropriate to infer indirect support from one statement for the claim made in another statement. + To further clarify, ranolazine is an antianginal medication used primarily for treating chronic angina pectoris by acting as an inhibitor of late sodium current in cardiac myocytes (Chaitman et al., 2004). Atrial fibrillation is an irregular heart rhythm that can lead to blood clots, stroke, heart failure, and other complications (National Heart, Lung, and Blood Institute). - In summary, no indirect support exists between these two statements due to their unrelated subject matter. The misinterpretation could lead to incorrect conclusions drawn from unrelated evidence, emphasizing the need for careful examination when interpreting scientific statements in context." -13653982,Ibuprofen causes Alzheimer disease,122,CONCLUSION: GVP is well-tolerated regimen with high response rate and needs to be tested in late relapsed HL.,False,Is the triple 'Ibuprofen causes Alzheimer disease' supported by the sentence: 'CONCLUSION: GVP is well-tolerated regimen with high response rate and needs to be tested in late relapsed HL.'?,"No, the statement ""Ibuprofen causes Alzheimer disease"" does not receive any direct or indirect support from the conclusion ""GVP is well-tolerated regimen with high response rate and needs to be tested in late relapsed HL."" + Although it is possible that certain medications could interact with ranolazine and potentially contribute to atrial fibrillation risk (e.g., via drug-drug interactions), the statement provided does not involve ranolazine nor suggest any link between ranolazine use and atrial fibrillation susceptibility. - The conclusion is about a treatment regimen (GVP) for late relapsed Hodgkin Lymphoma (HL) and its tolerability and response rate. Ibuprofen is not mentioned in the conclusion, nor is there any connection made between ibuprofen and Alzheimer disease. Therefore, there is no basis for such an inference in this context." -13133316,Ibuprofen causes peptic ulcer disease,123,Early treatment with addition of low dose prednisolone to methotrexate improves therapeutic outcome in severe psoriatic arthritis.,False,Is the triple 'Ibuprofen causes peptic ulcer disease' supported by the sentence: 'Early treatment with addition of low dose prednisolone to methotrexate improves therapeutic outcome in severe psoriatic arthritis.'?,"No, the statement ""Early treatment with addition of low dose prednisolone to methotrexate improves therapeutic outcome in severe psoriatic arthritis"" does not provide indirect support for the claim that ""Ibuprofen causes peptic ulcer disease."" + Chaitman BR, et al. Effect" +26862829,Prednisolone related to multiple sclerosis,207,Metabolic effects of high-dose prednisolone treatment in early rheumatoid arthritis: balance between diabetogenic effects and inflammation reduction.,False,"'Does the phrase ""Prednisolone related to multiple sclerosis"" receive at least indirect support from the statement: ""Metabolic effects of high-dose prednisolone treatment in early rheumatoid arthritis: balance between diabetogenic effects and inflammation reduction.""?","No, the statement does not provide indirect support for the phrase ""Prednisolone related to multiple sclerosis."" The statement discusses the metabolic effects of high-dose prednisolone treatment in early rheumatoid arthritis, focusing on its diabetogenic effects and inflammation reduction. Multiple sclerosis is an autoimmune disease affecting the central nervous system, and while prednisolone is a corticosteroid used in treating various inflammatory conditions (including multiple sclerosis), the statement in question does not establish a connection between prednisolone and multiple sclerosis specifically." +26365803,Prednisolone related to adrenocortical insufficiency,208,"Effects of prednisolone, salbutamol and theophylline on bronchial hyperreactivity and leucocyte chemokinesis in guinea pigs.",False,"'Does the phrase ""Prednisolone related to adrenocortical insufficiency"" receive at least indirect support from the statement: ""Effects of prednisolone, salbutamol and theophylline on bronchial hyperreactivity and leucocyte chemokinesis in guinea pigs.""?","No, the statement ""Effects of prednisolone, salbutamol and theophylline on bronchial hyperreactivity and leucocyte chemokinesis in guinea pigs"" does not provide indirect support for the phrase ""Prednisolone related to adrenocortical insufficiency."" - The two statements discuss different subjects: one is about a treatment regimen for psoriatic arthritis, while the other is about ibuprofen potentially causing peptic ulcer disease. The first statement does not mention ibuprofen nor imply any connection between ibuprofen use and peptic ulcer disease risk; therefore, it does not provide any indirect support for that claim. + The statement discusses the effects of prednisolone, along with salbutamol and theophylline, on bronchial hyperreactivity and leucocyte chemokinesis in guinea pigs. These parameters are related to respiratory function and inflammation, not adrenocortical insufficiency. - Peptic ulcer disease is an adverse effect associated with nonsteroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen; however, multiple factors can contribute to its development, including bacterial infections (e.g., Helicobacter pylori) and genetic predispositions. It is essential to maintain clear lines of evidence when interpreting statements in order to avoid misleading conclusions based on unrelated information." -12641386,Ibuprofen causes Fever,124,"CONCLUSION: Flu/Cy/ATG conditioning regimen, bone marrow as stem cell source and CSA, prednisolone and short methotrexate regimen were associated with better survival in AA.",False,"Is the triple 'Ibuprofen causes Fever' supported by the sentence: 'CONCLUSION: Flu/Cy/ATG conditioning regimen, bone marrow as stem cell source and CSA, prednisolone and short methotrexate regimen were associated with better survival in AA.'?","No, the phrase ""Ibuprofen causes fever"" does not receive any support from the statement provided. The conclusion mentioned refers to a study on allogeneic hematopoietic stem cell transplantation (HSCT) in patients with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS). It discusses various conditioning regimens and their impact on survival rates but does not mention ibuprofen or fever at all. Ibuprofen is an analgesic and anti-inflammatory drug, and it is not typically associated with causing fever; on the contrary, it is often used to reduce fever. Therefore, there is no indirect support for the claim that ibuprofen causes fever in this statement." -12482174,Ibuprofen causes pancreatitis,125,Effect of addition of short course of prednisolone to gluten-free diet on mucosal epithelial cell regeneration and apoptosis in celiac disease: a pilot randomized controlled trial.,False,Is the triple 'Ibuprofen causes pancreatitis' supported by the sentence: 'Effect of addition of short course of prednisolone to gluten-free diet on mucosal epithelial cell regeneration and apoptosis in celiac disease: a pilot randomized controlled trial.'?,"No, the statement does not provide any direct or indirect support for the claim that ibuprofen causes pancreatitis. The study mentioned is focused on examining the effect of adding a short course of prednisolone to a gluten-free diet on mucosal epithelial cell regeneration and apoptosis in celiac disease participants as part of a pilot randomized controlled trial. + Adrenocortical insufficiency refers to the inadequate production of corticosteroids by the adrenal glands, which can be caused by various factors such as damage to the adrenal glands or issues with the pituitary gland. Prednisolone is a synthetic glucocorticoid hormone that can be used to treat adrenocortical insufficiency, but the statement provided does not discuss or imply any relationship between prednisolone and adrenocortical insuff" +26295217,Prednisolone related to angioimmunoblastic T-cell lymphoma,209,"This is the first case to support the beneficial effect of prednisolone in pericarditis with pSS, and illustrates its safety during pregnancy.",False,"'Does the phrase ""Prednisolone related to angioimmunoblastic T-cell lymphoma"" receive at least indirect support from the statement: ""This is the first case to support the beneficial effect of prednisolone in pericarditis with pSS, and illustrates its safety during pregnancy.""?","No, the statement does not provide indirect support for the phrase ""Prednisolone related to angioimmunoblastic T-cell lymphoma"". The statement discusses the beneficial effect and safety of prednisolone in pericarditis with primary Sjogren's syndrome (pSS) during pregnancy. Angioimmunoblastic T-cell lymphoma is a distinct medical condition unrelated to pericarditis or pregnancy, so no inference can be made about prednisolone's impact on it based on this information." +26194122,Prednisolone related to synovitis,210,"When combined with environmental control, prednisolone and dexamethasone treatments had similar effects on heaves score, blood gases and endoscopic scores.",True,"'Does the phrase ""Prednisolone related to synovitis"" receive at least indirect support from the statement: ""When combined with environmental control, prednisolone and dexamethasone treatments had similar effects on heaves score, blood gases and endoscopic scores.""?","Yes, indirectly it does support the phrase ""Prednisolone related to synovitis"". The statement suggests that prednisolone treatment has an effect on heaves score, blood gases, and endoscopic scores in animals suffering from heaves (a chronic inflammatory airway disease in horses). Synovitis is an inflammation of the synovial membrane which can be associated with various conditions including chronic inflammatory diseases like heaves in horses. Therefore, prednisolone's impact on these scores may imply its involvement in managing synovitis as part of its broader anti-inflammatory effects in such conditions. However, it is important to note that this is an indirect inference based on prednisolone's known anti-inflammatory properties rather than direct evidence linking prednisolone specifically to synovitis management in horses with heaves." +25959730,Prednisolone related to sarcoma,211,"Of the 20 patients, 14 initially received prednisolone treatment, which resulted in rapid improvement and normalization of eosinophilia within 8 weeks; however, 2 patients with splenomegaly showed poor control of eosinophilia in response to corticosteroid treatment.",False,"'Does the phrase ""Prednisolone related to sarcoma"" receive at least indirect support from the statement: ""Of the 20 patients, 14 initially received prednisolone treatment, which resulted in rapid improvement and normalization of eosinophilia within 8 weeks; however, 2 patients with splenomegaly showed poor control of eosinophilia in response to corticosteroid treatment.""?","No, the statement does not provide direct or indirect support for the phrase ""Prednisolone related to sarcoma."" The statement discusses the response of 20 patients to prednisolone treatment for eosinophilia (high levels of eosinophils in the blood). While it mentions that two patients did not respond well to corticosteroid treatment (which includes prednisolone), it does not link prednisolone use to sarcoma development or progression. Sarcoma is a type of cancer that develops in connective tissue such as bone, cartilage, fat, muscle, blood vessels, or other supportive tissue in the body. The statement only discusses prednisolone's effect on eosinophilia control in these patients." +25621708,Prednisolone related to uveitis,212,Complement activation capacity in plasma before and during high-dose prednisolone treatment and tapering in exacerbations of Crohn's disease and ulcerative colitis.,True,"'Does the phrase ""Prednisolone related to uveitis"" receive at least indirect support from the statement: ""Complement activation capacity in plasma before and during high-dose prednisolone treatment and tapering in exacerbations of Crohn's disease and ulcerative colitis.""?","Yes, indirect support can be inferred from the statement provided. The study mentioned investigates complement activation capacity in plasma before and during high-dose prednisolone treatment in exacerbations of Crohn's disease and ulcerative colitis. Prednisolone is a corticosteroid often used in treating inflammatory conditions such as uveitis due to its anti-inflammatory properties. - The study does not involve ibuprofen use nor investigate its potential link to pancreatitis. In order to make an informed decision about whether ibuprofen causes pancreatitis, one should consult other relevant studies that specifically investigate ibuprofen use and its potential association with pancreatitis development." -12438812,Ibuprofen causes Toothache,126,Coadministration of cyclosporin a with prednisolone in acute interstitial pneumonia complicating polymyositis/dermatomyositis.,False,Is the triple 'Ibuprofen causes Toothache' supported by the sentence: 'Coadministration of cyclosporin a with prednisolone in acute interstitial pneumonia complicating polymyositis/dermatomyositis.'?,"No, the statement ""Coadministration of cyclosporin a with prednisolone in acute interstitial pneumonia complicating polymyositis/dermatomyositis"" does not provide any direct or indirect support for the claim ""Ibuprofen causes Toothache."" The two statements discuss unrelated medical issues (acute interstitial pneumonia complicating polymyositis/dermatomyositis vs toothache) and medications (cyclosporin a and prednisolone vs ibuprofen). + Although the statement does not explicitly connect prednisolone to uveitis, it does show that prednisolone is being used in treating inflammatory conditions (Crohn's disease and ulcerative colitis). Given that uveitis is an inflammatory condition affecting the eye, it is plausible that prednisolone could also be used in its treatment. This connection is supported by previous studies that have investigated the use of corticosteroids like prednisolone in treating uveitis (e.g., Solomon SD et al., 1997; Jabs DA et al., 2000). - Additionally, these statements come from different sources without any overlap in context or evidence that would allow for drawing connections between them. The first statement is focused on coadministration of cyclosporin a and prednisolone for treating acute interstitial pneumonia in polymyositis/dermatomyositis patients, while the second statement makes an unfounded claim about ibuprofen causing toothache without providing any supporting evidence or rationale. + However, it is essential to note that further investigation would be required for direct support of the connection between prednis" +24523226,Prednisolone related to glomerulonephritis,213,Prednisolone-responsive headache in patients with solitary cysticercus granuloma and seizures.,False,"'Does the phrase ""Prednisolone related to glomerulonephritis"" receive at least indirect support from the statement: ""Prednisolone-responsive headache in patients with solitary cysticercus granuloma and seizures.""?","No, the statement ""Prednisolone-responsive headache in patients with solitary cysticercus granuloma and seizures"" does not provide indirect support for the phrase ""Prednisolone related to glomerulonephritis"". - To establish a connection between these statements, one would need additional information linking ibuprofen use to toothache within the same context as the first statement. Since no" -12079834,Ibuprofen causes adult acute respiratory distress syndrome,127,"Efficacy of immunoglobulin plus prednisolone for prevention of coronary artery abnormalities in severe Kawasaki disease (RAISE study): a randomised, open-label, blinded-endpoints trial.",False,"Is the triple 'Ibuprofen causes adult acute respiratory distress syndrome' supported by the sentence: 'Efficacy of immunoglobulin plus prednisolone for prevention of coronary artery abnormalities in severe Kawasaki disease (RAISE study): a randomised, open-label, blinded-endpoints trial.'?","No, the statement does not provide any indirect support for the claim that ""Ibuprofen causes adult acute respiratory distress syndrome."" The RAISE study is focused on the efficacy of immunoglobulin plus prednisolone for prevention of coronary artery abnormalities in severe Kawasaki disease. It does not mention ibuprofen or acute respiratory distress syndrome at all. Therefore, it does not provide any basis for making such a connection or inferring causality between ibuprofen use and adult acute respiratory distress syndrome." -11157616,Ibuprofen causes Pain,128,"Response of vincristine, melphalan, cyclophosphamide and prednisolone in refractory multiple myeloma.",False,"Is the triple 'Ibuprofen causes Pain' supported by the sentence: 'Response of vincristine, melphalan, cyclophosphamide and prednisolone in refractory multiple myeloma.'?","No, the statement ""Response of vincristine, melphalan, cyclophosphamide and prednisolone in refractory multiple myeloma"" does not provide indirect support for the claim ""Ibuprofen causes Pain"". The statement discusses the effects of certain chemotherapeutic agents on refractory multiple myeloma, which is an unrelated topic to ibuprofen and its potential pain-causing effects." -10429873,Ibuprofen causes Hemorrhage,129,Pyruvate kinase M2 and prednisolone resistance in acute lymphoblastic leukemia.,False,Is the triple 'Ibuprofen causes Hemorrhage' supported by the sentence: 'Pyruvate kinase M2 and prednisolone resistance in acute lymphoblastic leukemia.'?,"No, the statement ""Pyruvate kinase M2 and prednisolone resistance in acute lymphoblastic leukemia"" does not provide indirect support for the claim ""Ibuprofen causes Hemorrhage."" The two statements discuss different concepts: pyruvate kinase M2 (PKM2) activation and prednisolone resistance in acute lymphoblastic leukemia (ALL) versus ibuprofen usage and hemorrhage risk. There is no connection between them that would allow for indirect support from one statement to the other. + The statement discusses the use of Prednisolone in managing headaches associated with solitary cysticercus granuloma and seizures. Glomerulonephritis is a kidney disease that involves inflammation of the glomeruli - structures within the kidney that filter waste from the bloodstream. There is no mention of Prednisolone having any effect on glomerulonephritis in this statement. - To further elaborate on why there is no connection between these two statements: + Therefore, without additional information linking Prednisolone to glomerulonephritis, it cannot be inferred that Prednisolone is related to glomerulonephritis based on this statement alone." +23496152,Prednisolone related to subacute thyroiditis,214,"The patient was treated with chemotherapy by cyclophosphamide, hydroxydoxorubicin, vincristine and prednisolone (CHOP), however, it was ineffective, and the patient died of hemorrhage from the lymphoma involvement of the intestine 5 months after the onset of disease.",True,"'Does the phrase ""Prednisolone related to subacute thyroiditis"" receive at least indirect support from the statement: ""The patient was treated with chemotherapy by cyclophosphamide, hydroxydoxorubicin, vincristine and prednisolone (CHOP), however, it was ineffective, and the patient died of hemorrhage from the lymphoma involvement of the intestine 5 months after the onset of disease.""?","Yes, there is indirect support for the phrase ""Prednisolone related to subacute thyroiditis"" in the statement provided. - - Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) commonly used for pain relief and reducing inflammation. Hemorrhage (or bleeding) is one potential side effect associated with long-term use or high doses due to its effect on platelet function and blood vessel dilation. + The statement indicates that a patient was treated with CHOP (cyclophosphamide, hydroxydoxorubicin, vincristine, and prednisolone) for lymphoma. However, the treatment was ineffective, and the patient died 5 months after disease onset due to hemorrhage from lymphoma involvement of the intestine. - - The second statement refers to pyruvate kinase M2 (PKM2) activation and prednisolone resistance in acute lymph" -9800201,Ibuprofen causes arthritic joint disease,130,"Stimulation with prednisolone and TNFalpha reduced GDF-5 expression in OA and RA fibroblasts, whereas MTX and IL-1beta revealed minor or no relevant change.",False,"Is the triple 'Ibuprofen causes arthritic joint disease' supported by the sentence: 'Stimulation with prednisolone and TNFalpha reduced GDF-5 expression in OA and RA fibroblasts, whereas MTX and IL-1beta revealed minor or no relevant change.'?","No, the statement does not provide any indirect support for the phrase ""Ibuprofen causes arthritic joint disease."" The statement discusses the effects of prednisolone, TNFalpha, MTX (methotrexate), and IL-1beta on GDF-5 (growth differentiation factor 5) expression in osteoarthritis (OA) and rheumatoid arthritis (RA) fibroblasts. Ibuprofen is not mentioned in the statement; therefore, it does not contribute any information that could be used to infer a relationship between ibuprofen and arthritic joint disease. + Prednisolone is a corticosteroid often used in the treatment of subacute thyroiditis due to its anti-inflammatory properties, which can help alleviate symptoms such as pain and swelling (Nakao et al., 2018). While it is not explicitly stated that prednisolone was used specifically for subacute thyroiditis in this case, its inclusion in the treatment regimen suggests that it may have been used for managing symptoms associated with inflammation in general. - To provide indirect support for the initial phrase, one would need information connecting ibuprofen usage with an increased risk or development of arthritic joint disease. As a computational biologist, it is important to base conclusions on relevant evidence presented in order to maintain accuracy in interpreting scientific literature." -8163776,Ibuprofen causes injury,131,"A combination of rituximab plus chemotherapy, rituximab+cyclophosphamide+doxorubicin+vincristine+prednisolone (R-CHOP), has the highest efficacy ever described with any chemotherapy in DLBCL and FL.",False,"Is the triple 'Ibuprofen causes injury' supported by the sentence: 'A combination of rituximab plus chemotherapy, rituximab+cyclophosphamide+doxorubicin+vincristine+prednisolone (R-CHOP), has the highest efficacy ever described with any chemotherapy in DLBCL and FL.'?","No, the statement does not provide indirect support for the phrase ""Ibuprofen causes injury."" The statement discusses the efficacy of a specific chemotherapy regimen (R-CHOP) in treating certain types of lymphoma (diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma (FL)). Ibuprofen is an over-the-counter nonsteroidal anti-inflammatory drug (NSAID) used for pain relief, fever reduction, and inflammation. The two statements discuss unrelated topics; therefore, there is no connection between them that would lend support to the claim about ibuprofen causing injury." -26701175,Ibuprofen affects rheumatoid arthritis,132,"A combination of rituximab plus chemotherapy, rituximab+cyclophosphamide+doxorubicin+vincristine+prednisolone (R-CHOP), has the highest efficacy ever described with any chemotherapy in DLBCL and FL.",False,"Is the triple 'Ibuprofen affects rheumatoid arthritis' supported by the sentence: 'A combination of rituximab plus chemotherapy, rituximab+cyclophosphamide+doxorubicin+vincristine+prednisolone (R-CHOP), has the highest efficacy ever described with any chemotherapy in DLBCL and FL.'?","No, the statement does not provide indirect support for the claim that ibuprofen affects rheumatoid arthritis. The statement discusses the efficacy of R-CHOP (a specific chemotherapy regimen) in treating diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma (FL). Ibuprofen is an analgesic and anti-inflammatory drug used primarily for pain relief, fever reduction, and inflammation. While both statements pertain to medical treatments, they discuss different conditions and therapeutic approaches without any overlap or connection between them that would allow for indirect support." -24384432,Ibuprofen affects migraine disorder,133,Weekly docetaxel and prednisolone versus prednisolone alone in androgen-independent prostate cancer: a randomized phase II study.,False,Is the triple 'Ibuprofen affects migraine disorder' supported by the sentence: 'Weekly docetaxel and prednisolone versus prednisolone alone in androgen-independent prostate cancer: a randomized phase II study.'?,"No, the statement does not provide indirect support for the phrase ""Ibuprofen affects migraine disorder."" The study mentioned is investigating the effects of docetaxel and prednisolone on androgen-independent prostate cancer, as indicated by its title: ""Weekly docetaxel and prednisolone versus prednisolone alone in androgen-independent prostate cancer: a randomized phase II study."" Ibuprofen is neither mentioned nor tested in this study; thus, there is no connection between the study results and ibuprofen's effects on migraines. + However, it is essential to acknowledge that prednisolone was part of a combination therapy (CHOP) aimed" +22194722,Prednisolone related to pulmonary eosinophilia,215,Effect of prednisolone in the experimentally induced nephropathy in male albino rats.,False,"'Does the phrase ""Prednisolone related to pulmonary eosinophilia"" receive at least indirect support from the statement: ""Effect of prednisolone in the experimentally induced nephropathy in male albino rats.""?","No, the statement ""Effect of prednisolone in the experimentally induced nephropathy in male albino rats"" does not provide indirect support for the phrase ""Prednisolone related to pulmonary eosinophilia."" - - To further clarify, let us explore how indirect support could be established in other scenarios: + The reason is that the experiment does not involve pulmonary eosinophilia; it focuses on nephropathy in rats. Nephropathy is a term used to describe disease of the kidney, which is not related to pulmonary eosinophilia, a condition characterized by an increased number of eosinophils in the lungs. Therefore, while prednisolone may have an effect on nephropathy, as suggested by the study, it does not necessarily imply that prednisolone is related to pulmonary eosinophilia." +21911849,Prednisolone related to habitual spontaneous abortion,216,[On the effect of oral use of prednisolone on central chorioretinitis].,False,"'Does the phrase ""Prednisolone related to habitual spontaneous abortion"" receive at least indirect support from the statement: ""[On the effect of oral use of prednisolone on central chorioretinitis].""?","No, the statement does not provide indirect support for the phrase ""Prednisolone related to habitual spontaneous abortion."" The statement discusses the effect of oral use of prednisolone on central chorioretinitis, which is an eye condition. It does not mention or imply anything about prednisolone's potential relationship with habitual spontaneous abortion, which is a term used to describe repeated miscarriages without known cause. Therefore, there is no basis for drawing a connection between these two distinct concepts based on the provided statement." +20512112,Prednisolone related to castration-resistant prostate carcinoma,217,Peptic ulceration associated with prednisolone therapy.,False,"'Does the phrase ""Prednisolone related to castration-resistant prostate carcinoma"" receive at least indirect support from the statement: ""Peptic ulceration associated with prednisolone therapy.""?","No, the statement ""Peptic ulceration associated with prednisolone therapy"" does not provide indirect support for the phrase ""Prednisolone related to castration-resistant prostate carcinoma"". - - - If there were shared mechanisms between prostate cancer treatment and migraine prevention (e.g., anti-inflammatory effects), then studies showing benefits for prostate cancer could indirectly imply potential benefits for migraine treatment if ibuprofen were involved in those shared mechanisms. + Prednisolone is a synthetic glucocorticoid often used in treating various medical conditions due to its anti-inflammatory and immunosuppressive properties. The statement indicates that prednisolone therapy is associated with peptic ulceration, which is a known side effect of long-term corticosteroid use affecting the gastrointestinal system. - - - If ibuprofen were mentioned in another study investigating its effects on migraines, that would provide indirect support for ""Ibuprofen affects migraine disorder" -23500890,Ibuprofen affects adult acute respiratory distress syndrome,134,Prednisolone and azathioprine in membranous nephropathy: a 10-year follow-up study.,False,Is the triple 'Ibuprofen affects adult acute respiratory distress syndrome' supported by the sentence: 'Prednisolone and azathioprine in membranous nephropathy: a 10-year follow-up study.'?,"No, the statement ""Prednisolone and azathioprine in membranous nephropathy: a 10-year follow-up study"" does not provide any direct or indirect support for the claim that ""Ibuprofen affects adult acute respiratory distress syndrome."" The study in question focuses on prednisolone and azathioprine as treatments for membranous nephropathy over a 10-year period. Ibuprofen is not mentioned at all in the study, making it irrelevant in supporting or refuting the claim about ibuprofen's effects on adult acute respiratory distress syndrome." -21214366,Ibuprofen affects bronchopulmonary dysplasia,135,"Taken together, the present study points to a strong inhibitory effect of liposomal PLP on tumor angiogenesis by reduction of the intratumoral production of the majority of pro-angiogenic factors studied and direct inhibition of endothelial cell proliferation, which is the result of high prolonged levels of prednisolone in the tumor by liposomal delivery.",False,"Is the triple 'Ibuprofen affects bronchopulmonary dysplasia' supported by the sentence: 'Taken together, the present study points to a strong inhibitory effect of liposomal PLP on tumor angiogenesis by reduction of the intratumoral production of the majority of pro-angiogenic factors studied and direct inhibition of endothelial cell proliferation, which is the result of high prolonged levels of prednisolone in the tumor by liposomal delivery.'?","No, the statement does not provide indirect support for the phrase ""Ibuprofen affects bronchopulmonary dysplasia."" The statement discusses the inhibitory effect of liposomal PLP on tumor angiogenesis through reducing pro-angiogenic factors and inhibiting endothelial cell proliferation due to high prolonged levels of prednisolone in the tumor by liposomal delivery. This information is related to tumor angiogenesis and drug delivery mechanisms rather than ibuprofen and bronchopulmonary dysplasia." -20886939,Ibuprofen affects Cognitive impairment,136,Prednisolone versus dexamethasone in croup: a randomised equivalence trial.,False,Is the triple 'Ibuprofen affects Cognitive impairment' supported by the sentence: 'Prednisolone versus dexamethasone in croup: a randomised equivalence trial.'?,"No, the statement ""Prednisolone versus dexamethasone in croup: a randomised equivalence trial"" does not provide any direct or indirect support for the claim that ""Ibuprofen affects Cognitive impairment."" This study investigates the effects of prednisolone versus dexamethasone on croup in children; it does not involve ibuprofen nor cognitive impairment in any way that would allow for an inference regarding ibuprofen's impact on cognitive impairment." -18977843,Ibuprofen affects Headache,137,Use of ACTH and prednisolone in infantile spasms: experience from a developing country.,False,Is the triple 'Ibuprofen affects Headache' supported by the sentence: 'Use of ACTH and prednisolone in infantile spasms: experience from a developing country.'?,"No, the statement ""Use of ACTH and prednisolone in infantile spasms: experience from a developing country"" does not provide any direct or indirect support for the phrase ""Ibuprofen affects Headache."" The study primarily focuses on the use of ACTH (Adrenocorticotropic hormone) and prednisolone in treating infantile spasms in a developing country setting. Ibuprofen is not mentioned in the study, nor is there any discussion about headaches or related topics. Therefore, it is not appropriate to draw any conclusions about ibuprofen's effect on headaches based on this study." -15746938,Ibuprofen affects injury,138,Bone mineral density in relation to efficacy and side effects of budesonide and prednisolone in Crohn's disease.,False,Is the triple 'Ibuprofen affects injury' supported by the sentence: 'Bone mineral density in relation to efficacy and side effects of budesonide and prednisolone in Crohn's disease.'?,"No, the phrase ""Ibuprofen affects injury"" does not receive indirect support from the statement: ""Bone mineral density in relation to efficacy and side effects of budesonide and prednisolone in Crohn's disease."" + On the other hand, castration-resistant prostate carcinoma is an aggressive form of prostate cancer that progresses despite medical or surgical treatments aimed at reducing testosterone levels in the body. While glucocorticoids like prednisolone have been used in treating prostate cancer due to their ability to inhibit tumor growth by suppressing factors involved in cancer cell proliferation, there is no direct evidence in the statement provided that establishes a connection between prednisolone usage and castration-resistant prostate carcinoma development or progress" +20312000,Prednisolone related to chronic primary adrenal insufficiency,218,"Glucocorticoids (e.g. prednisolone) are cornerstones in the treatment of acute exacerbations of ulcerative colitis (UC), and influence of the leucocyte/endothelial interaction appears to be part of their mode of action.",True,"'Does the phrase ""Prednisolone related to chronic primary adrenal insufficiency"" receive at least indirect support from the statement: ""Glucocorticoids (e.g. prednisolone) are cornerstones in the treatment of acute exacerbations of ulcerative colitis (UC), and influence of the leucocyte/endothelial interaction appears to be part of their mode of action.""?","Yes, there is indirect support for the phrase ""Prednisolone related to chronic primary adrenal insufficiency"" from the statement provided. The reason behind this is that glucocorticoids like prednisolone can impact adrenal gland function over time due to their mechanism of action in treating conditions like ulcerative colitis (UC). - The statement provided discusses bone mineral density in relation to two specific pharmaceutical drugs (budesonide and prednisolone) used in treating Crohn's disease, which is an inflammatory bowel disease. Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) commonly used for pain relief, including injuries. + Glucocorticoids such as prednisolone work by suppressing inflammation in UC patients by affecting leukocyte-endothelial interactions. However, long-term use of these medications can lead to decreased production of cortisol by the adrenal glands since they mimic natural corticosteroids in the body. This can result in chronic primary adrenal insufficiency (CAI), which is characterized by reduced cortisol secretion due to adrenal gland dysfunction. - Although both ibuprofen and budesonide/prednisolone have anti-inflammatory effects, they function differently and target various biological pathways. The statement does not provide any information about ibuprofen or its effects on injuries. Therefore, it does not offer indirect support for the claim that ""Ibuprofen affects injury."" + While the statement does not explicitly mention CAI, it does provide evidence for prednisolone affecting adrenal gland function in some capacity due to its glucocorticoid properties. Therefore, it is reasonable to infer an indirect relationship between prednisolone use and chronic primary adrenal insuff" +20106181,Prednisolone related to allergic bronchopulmonary aspergillosis,219,"Effects of honey, prednisolone, and disulfiram on inflammation, nitric oxide, and free radical formation.",False,"'Does the phrase ""Prednisolone related to allergic bronchopulmonary aspergillosis"" receive at least indirect support from the statement: ""Effects of honey, prednisolone, and disulfiram on inflammation, nitric oxide, and free radical formation.""?","No, the statement ""Effects of honey, prednisolone, and disulfiram on inflammation, nitric oxide, and free radical formation"" does not provide indirect support for the phrase ""Prednisolone related to allergic bronchopulmonary aspergillosis"". - However, it is worth mentioning that there is an established body of evidence indicating that NSAIDs like ibuprofen can negatively affect bone health by decreasing bone formation and increasing bone" -13826486,Ibuprofen affects osteoarthritis,139,OBJECTIVE: To examine the safety and efficacy of methotrexate (MTX) plus low-dose prednisolone for induction of remission in non life- or organ-threatening courses and for remission maintenance in Churg-Strauss syndrome (CSS).,False,Is the triple 'Ibuprofen affects osteoarthritis' supported by the sentence: 'OBJECTIVE: To examine the safety and efficacy of methotrexate (MTX) plus low-dose prednisolone for induction of remission in non life- or organ-threatening courses and for remission maintenance in Churg-Strauss syndrome (CSS).'?,"No, the statement does not provide any direct or indirect support for the phrase ""Ibuprofen affects osteoarthritis."" The objective in the statement is focused on examining the safety and efficacy of methotrexate (MTX) plus low-dose prednisolone for induction of remission in non life- or organ-threatening courses and for remission maintenance in Churg-Strauss syndrome (CSS). Ibuprofen is not mentioned in the statement at all, let alone its potential effects on osteoarthritis." -13584223,Ibuprofen affects Cognitive impairment,140,OBJECTIVE: To determine whether addition of low dose prednisolone to multidrug treatment can prevent reaction and nerve function impairment in leprosy.,False,Is the triple 'Ibuprofen affects Cognitive impairment' supported by the sentence: 'OBJECTIVE: To determine whether addition of low dose prednisolone to multidrug treatment can prevent reaction and nerve function impairment in leprosy.'?,"No, the statement does not provide any direct or indirect support for the claim that ""Ibuprofen affects Cognitive impairment"". The objective in the statement is focused on determining whether adding low-dose prednisolone (a steroid medication) to multidrug treatment can prevent reaction and nerve function impairment in leprosy patients. There is no mention of ibuprofen, cognitive impairment, or any related concepts in this statement." -12659717,Ibuprofen affects Fever,141,A double-blind randomized controlled trial of infliximab associated with prednisolone in acute alcoholic hepatitis.,False,Is the triple 'Ibuprofen affects Fever' supported by the sentence: 'A double-blind randomized controlled trial of infliximab associated with prednisolone in acute alcoholic hepatitis.'?,"No, the statement ""A double-blind randomized controlled trial of infliximab associated with prednisolone in acute alcoholic hepatitis"" does not provide direct or indirect support for the claim that ""Ibuprofen affects Fever."" + The statement discusses the general effects of honey, prednisolone, and disulfiram on inflammation, nitric oxide, and free radical formation. It does not mention or imply any connection between prednisolone and allergic bronchopulmonary aspergillosis. Allergic bronchopulmonary aspergillosis is a specific condition related to hypersensitivity reactions to Aspergillus fungi, and while prednisolone may be used in its treatment due to its anti-inflammatory properties, the statement does not provide evidence for such a connection. Therefore, it does not indirectly support the phrase ""Prednisolone related to allergic bronchopulmonary aspergillosis""." +19750187,Prednisolone related to lymphoma,220,OBJECTIVE: To assess the treatment effect of sodium hyaluronate (HA) on experimental temporomandibular joint (TMJ) osteoarthritis of rabbits in comparison with prednisolone (PS).,False,"'Does the phrase ""Prednisolone related to lymphoma"" receive at least indirect support from the statement: ""OBJECTIVE: To assess the treatment effect of sodium hyaluronate (HA) on experimental temporomandibular joint (TMJ) osteoarthritis of rabbits in comparison with prednisolone (PS).""?","No, the statement does not provide indirect support for the phrase ""Prednisolone related to lymphoma."" The objective of the study is to assess the treatment effect of sodium hyaluronate (HA) on experimental temporomandibular joint (TMJ) osteoarthritis of rabbits in comparison with prednisolone (PS). This statement is about comparing two treatments for TMJ osteoarthritis in rabbits, not about any potential relationship between prednisolone and lymphoma." +17143213,Prednisolone related to temporal arteritis,221,"ETO+PSL combination treatment, however, failed to show significant enhancement of anti-tumor effects.",False,"'Does the phrase ""Prednisolone related to temporal arteritis"" receive at least indirect support from the statement: ""ETO+PSL combination treatment, however, failed to show significant enhancement of anti-tumor effects.""?","No, the statement ""ETO+PSL combination treatment, however, failed to show significant enhancement of anti-tumor effects"" does not provide indirect support for the phrase ""Prednisolone related to temporal arteritis."" The statement discusses the combination of ETO (presumably a drug abbreviation) and PSL (Prednisolone) in relation to anti-tumor effects, which is unrelated to temporal arteritis. Temporal arteritis is a condition characterized by inflammation in the lining of temporal arteries, often treated with corticosteroids like Prednisolone due to their anti-inflammatory properties. The lack of enhanced anti-tumor effects from combining ETO and PSL does not imply any connection to temporal arteritis." +16983852,Prednisolone related to Hodgkins lymphoma,222,"My- and My+ ALL did not significantly differ in sensitivity to prednisolone, dexamethasone, L-asparaginase and cytarabine.",False,"'Does the phrase ""Prednisolone related to Hodgkins lymphoma"" receive at least indirect support from the statement: ""My- and My+ ALL did not significantly differ in sensitivity to prednisolone, dexamethasone, L-asparaginase and cytarabine.""?","No, the statement does not provide indirect support for the phrase ""Prednisolone related to Hodgkins lymphoma."" The statement discusses the sensitivity of My- and My+ acute lymphoblastic leukemia (ALL) to various drugs including prednisolone, but it does not make any connection between prednisolone and Hodgkin lymphoma. Hodgkin lymphoma is a distinct type of cancer from acute lymphoblastic leukemia, so sensitivity in one does not necessarily imply sensitivity in the other. Furthermore, the statement suggests that there is no significant difference in sensitivity between My- and My+ ALL to prednisolone, which would argue against a specific relationship between prednisolone and Hodgkin lymphoma." +16960031,Prednisolone related to psoriatic arthritis,223,"The dose of prednisolone was increased considering he was exacerbated of SLE, however, the convulsion as CNS lupus occurred to him.",False,"'Does the phrase ""Prednisolone related to psoriatic arthritis"" receive at least indirect support from the statement: ""The dose of prednisolone was increased considering he was exacerbated of SLE, however, the convulsion as CNS lupus occurred to him.""?","No, the statement does not provide indirect support for the phrase ""Prednisolone related to psoriatic arthritis"". The statement discusses a patient with systemic lupus erythematosus (SLE) who experienced a convulsion due to central nervous system lupus after their prednisolone dose was increased due to an SLE exacerbation. Psoriatic arthritis is a distinct condition from SLE and is not mentioned in the statement. Therefore, there is no connection drawn between prednisolone use and psoriatic arthritis in this context." +16502712,Prednisolone related to aplastic anemia,224,"In a pilot study using one rabbit, prednisone and prednisolone clearance values increased with increase in either prednisone or prednisolone infusion rates.",False,"'Does the phrase ""Prednisolone related to aplastic anemia"" receive at least indirect support from the statement: ""In a pilot study using one rabbit, prednisone and prednisolone clearance values increased with increase in either prednisone or prednisolone infusion rates.""?","No, the statement does not provide indirect support for the phrase ""Prednisolone related to aplastic anemia."" - This study investigates the effects of infliximab combined with prednisolone on acute alcoholic hepatitis. The medications involved in this trial have no direct relationship to ibuprofen, which is an over-the-counter nonsteroidal anti-inflammatory drug (NSAID) commonly used for pain relief, fever reduction, and inflammation. + The statement discusses the clearance values of prednisone and prednisolone in a rabbit model when the infusion rates of these drugs are increased. While it suggests that there may be some pharmacokinetic interaction between prednisone and prednisolone, it does not provide any information about their potential toxicity or adverse effects such as aplastic anemia. - While ibuprofen is known for its ability to reduce fever by inhibiting prostaglandin synthesis in the hypothalamus, the evidence presented in this statement does not contribute any new information that would support or refute that understanding. + Aplastic anemia is a condition characterized by pancytopenia (a decrease in all types of blood cells) due to bone marrow failure. The relationship between glucocorticoids like prednisolone and aplastic anemia is complex and not fully understood. Some studies suggest that high-dose glucocorticoids may cause bone marrow suppression leading to aplastic anemia in certain individuals; however, other studies suggest that glucocorticoids may have a protective effect in bone marrow failure syndromes. - In conclusion, it is essential to remain cautious when drawing connections between unrelated studies or statements since doing so may lead to incorrect conclusions and misunderstandings in interpreting evidence-based knowledge." -11207850,Ibuprofen affects peptic ulcer disease,142,EULAR randomised controlled trial of pulse cyclophosphamide and methylprednisolone versus continuous cyclophosphamide and prednisolone followed by azathioprine and prednisolone in lupus nephritis.,False,Is the triple 'Ibuprofen affects peptic ulcer disease' supported by the sentence: 'EULAR randomised controlled trial of pulse cyclophosphamide and methylprednisolone versus continuous cyclophosphamide and prednisolone followed by azathioprine and prednisolone in lupus nephritis.'?,"No, the statement does not provide any direct or indirect support for the claim that ""Ibuprofen affects peptic ulcer disease."" The EULAR randomized controlled trial mentioned in the statement is focused on comparing different treatment regimens for lupus nephritis. Ibuprofen is not mentioned in the statement at all, let alone in relation to peptic ulcer disease. Therefore, it is not possible to draw any conclusions about ibuprofen's effects on peptic ulcer disease based on this statement alone." -11159990,Ibuprofen affects Hemorrhage,143,OBJECTIVE: To investigate the safety and efficacy of leflunomide plus low-dose prednisolone for the maintenance of remission in Wegener's granulomatosis (WG).,False,Is the triple 'Ibuprofen affects Hemorrhage' supported by the sentence: 'OBJECTIVE: To investigate the safety and efficacy of leflunomide plus low-dose prednisolone for the maintenance of remission in Wegener's granulomatosis (WG).'?,"No, the statement does not provide any direct or indirect support for the phrase ""Ibuprofen affects Hemorrhage."" The objective in question is about investigating the safety and efficacy of leflunomide plus low-dose prednisolone for maintaining remission in Wegener's granulomatosis (WG). Ibuprofen is not mentioned in this statement, nor is there any implied connection between ibuprofen use and hemorrhage incidence in patients suffering from WG or other related conditions. It is essential to base conclusions on specific evidence related to the subject matter under consideration." -10170540,Ibuprofen affects patent ductus arteriosus,144,"Treatment with combined therapy of adriamycin, vincristine and prednisolone produced a remission in the leukaemia with complete resolution of the breast mass.",False,"Is the triple 'Ibuprofen affects patent ductus arteriosus' supported by the sentence: 'Treatment with combined therapy of adriamycin, vincristine and prednisolone produced a remission in the leukaemia with complete resolution of the breast mass.'?","No, the statement does not provide any direct or indirect support for the phrase ""Ibuprofen affects patent ductus arteriosus"". The statement discusses the effects of a combined therapy (adriamycin, vincristine, and prednisolone) on leukaemia and breast mass resolution, which is unrelated to ibuprofen and its potential impact on patent ductus arteriosus (PDA), a congenital heart defect in newborns. Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) commonly used for pain relief and reducing inflammation, while adriamycin, vincristine, and prednisolone are chemotherapy drugs used in cancer treatment. Therefore, these two scenarios involve different medical contexts and therapeutic agents, making it impossible to draw any connection between them." -10026104,Ibuprofen affects Myalgia,145,RESULTS: The average initial dose of prednisolone in polymyalgia rheumatica was 35 mg; 51 of 62 patients were given a starting dose exceeding 15 mg.,False,Is the triple 'Ibuprofen affects Myalgia' supported by the sentence: 'RESULTS: The average initial dose of prednisolone in polymyalgia rheumatica was 35 mg; 51 of 62 patients were given a starting dose exceeding 15 mg.'?,"No, the statement does not provide indirect support for the phrase ""Ibuprofen affects Myalgia."" The statement discusses the initial dose of prednisolone given to patients with polymyalgia rheumatica but does not mention ibuprofen or myalgia at all. Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) used for pain relief, while myalgia refers to muscle pain or tenderness; they have no direct connection to prednisolone or polymyalgia rheumatica in this context." -9889792,Ibuprofen affects Hemorrhage,146,[Trans-utero-tubal administration of prednisolone in sterility caused by obstruction of the tubes].,False,Is the triple 'Ibuprofen affects Hemorrhage' supported by the sentence: '[Trans-utero-tubal administration of prednisolone in sterility caused by obstruction of the tubes].'?,"No, the statement does not provide any direct or indirect support for the phrase ""Ibuprofen affects Hemorrhage."" The statement discusses the administration of prednisolone in sterility caused by obstruction of the tubes, which is unrelated to ibuprofen and hemorrhage. Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) commonly used for pain relief, whereas prednisolone is a corticosteroid medication used for suppressing the immune system and reducing inflammation in various conditions. Hemorrhage refers to excessive bleeding, which is not mentioned in the provided statement." -8819538,Ibuprofen affects osteoarthritis,147,[On experiences with a combination preparation from prednisolone and an antihistaminic in dermatology especially in endogenous eczema].,False,Is the triple 'Ibuprofen affects osteoarthritis' supported by the sentence: '[On experiences with a combination preparation from prednisolone and an antihistaminic in dermatology especially in endogenous eczema].'?,"No, the statement does not provide any direct or indirect support for the claim that ""Ibuprofen affects osteoarthritis."" The statement discusses the use of prednisolone and an antihistaminic in dermatology, specifically for endogenous eczema. It does not mention ibuprofen or osteoarthritis at all. Therefore, it does not contribute any relevant information to evaluate the claim about ibuprofen's effect on osteoarthritis." -8421263,Ibuprofen affects Fever,148,[USE OF PREDNISOLONE IN SOME GRAVE FORMS OF PATHOLOGY OF THE PREMATURE INFANT].,False,Is the triple 'Ibuprofen affects Fever' supported by the sentence: '[USE OF PREDNISOLONE IN SOME GRAVE FORMS OF PATHOLOGY OF THE PREMATURE INFANT].'?,"No, the statement does not provide any direct or indirect support for the claim that ibuprofen affects fever in individuals. The statement discusses the use of prednisolone in some grave forms of pathology in premature infants, while the claim is about ibuprofen affecting fever in general populations. The two statements refer to different medications and contexts; therefore, there is no connection between them that would support the claim about ibuprofen affecting fever." -27630106,Ibuprofen disrupts Acute Pain,149,[EFFECT OF PREDNISOLONE ON THE CARDIAC ACTIVITY IN LIVER AND KIDNEY DISEASES AND IN RHEUMATISM].,False,Is the triple 'Ibuprofen disrupts Acute Pain' supported by the sentence: '[EFFECT OF PREDNISOLONE ON THE CARDIAC ACTIVITY IN LIVER AND KIDNEY DISEASES AND IN RHEUMATISM].'?,"No, the statement does not provide any direct or indirect support for the phrase ""Ibuprofen disrupts Acute Pain"". The statement discusses the effects of Prednisolone on cardiac activity in liver and kidney diseases as well as rheumatism. It does not mention Ibuprofen or acute pain at all. Therefore, it does not contribute to our understanding or validation of that specific claim." -23399675,Ibuprofen disrupts Myalgia,150,"In this limited pilot study, we compared the effect on clinical outcome of treating Pseudomonas keratitis in guinea pigs with prednisolone (a corticosteroid), flurbiprofen (a cyclo-oxygenase inhibitor), nordihydroguaiaretic acid (a lipoxygenase inhibitor), and a leukotriene antagonist, SKF104353 [R-(R*, S*)]-beta-[(2-carboxyethyl) thio-alpha-hydroxy-2-(8-phenyloctyl) benzenepropanoic acid, zinc salt].",False,"Is the triple 'Ibuprofen disrupts Myalgia' supported by the sentence: 'In this limited pilot study, we compared the effect on clinical outcome of treating Pseudomonas keratitis in guinea pigs with prednisolone (a corticosteroid), flurbiprofen (a cyclo-oxygenase inhibitor), nordihydroguaiaretic acid (a lipoxygenase inhibitor), and a leukotriene antagonist, SKF104353 [R-(R*, S*)]-beta-[(2-carboxyethyl) thio-alpha-hydroxy-2-(8-phenyloctyl) benzenepropanoic acid, zinc salt].'?","No, the statement does not provide indirect support for the phrase ""Ibuprofen disrupts Myalgia."" The study referenced in the statement investigates different treatments for Pseudomonas keratitis in guinea pigs, including prednisolone, flurbiprofen, nordihydroguaiaretic acid, and SKF104353. Ibuprofen is not mentioned in the study, so there is no connection between its effects on myalgia and the results presented in this study. Myalgia is muscle pain or discomfort, while Pseudomonas keratitis is an eye infection; these conditions have different underlying causes and would require different treatments." -18599970,Ibuprofen disrupts arthritic joint disease,151,URINARY EXCRETION OF PREDNISOLONE AFTER INTRARECTAL THERAPY IN ULCERATIVE COLITIS.,False,Is the triple 'Ibuprofen disrupts arthritic joint disease' supported by the sentence: 'URINARY EXCRETION OF PREDNISOLONE AFTER INTRARECTAL THERAPY IN ULCERATIVE COLITIS.'?,"No, the statement ""URINARY EXCRETION OF PREDNISOLONE AFTER INTRARECTAL THERAPY IN ULCERATIVE COLITIS"" does not provide indirect support for the phrase ""Ibuprofen disrupts arthritic joint disease."" The statement pertains specifically to prednisolone excretion in patients with ulcerative colitis who have undergone intrarectal therapy, which is unrelated to ibuprofen's potential effects on arthritic joint disease." -15072611,Ibuprofen disrupts Fever,152,"Male rats treated with either budesonide, prednisolone, or triamcinolone acetonide in drinking water for up to 104 weeks developed slightly increased incidences of basophilic foci, and significantly increased incidences of combined hepatocellular adenomas/carcinomas as compared to controls.",False,"Is the triple 'Ibuprofen disrupts Fever' supported by the sentence: 'Male rats treated with either budesonide, prednisolone, or triamcinolone acetonide in drinking water for up to 104 weeks developed slightly increased incidences of basophilic foci, and significantly increased incidences of combined hepatocellular adenomas/carcinomas as compared to controls.'?","No, the statement does not provide indirect support for the phrase ""Ibuprofen disrupts Fever"". The statement discusses the effects of three different corticosteroids (budesonide, prednisolone, and triamcinolone acetonide) on rats over an extended period (up to 104 weeks), focusing on hepatic lesions (basophilic foci and hepatocellular adenomas/carcinomas). Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) used primarily for its analgesic, antipyretic, and anti-inflammatory properties; it does not belong to the class of corticosteroids mentioned in the given statement. + Therefore, without additional evidence linking prednisolone use to apl" +16371065,Prednisolone related to celiac disease,225,"Budesonide is equal to less effective than prednisolone or prednisone therapy in the treatment of active Crohn's disease, but is associated with fewer glucocorticoids adverse reactions.",False,"'Does the phrase ""Prednisolone related to celiac disease"" receive at least indirect support from the statement: ""Budesonide is equal to less effective than prednisolone or prednisone therapy in the treatment of active Crohn's disease, but is associated with fewer glucocorticoids adverse reactions.""?","No, the statement does not provide indirect support for the phrase ""Prednisolone related to celiac disease."" The statement discusses the efficacy of Budesonide versus Prednisolone in treating Crohn's disease and mentions side effects associated with Prednisolone. However, it does not mention or imply any connection between Prednisolone and celiac disease. Celiac disease is an autoimmune disorder where gluten triggers immune system activity leading to damage in the small intestine, while Prednisolone is a corticosteroid used in treating various conditions such as inflammation, allergies, and autoimmune disorders but not specifically celiac disease." +16192798,Prednisolone related to dermatomyositis,226,Diclofenac and prednisolone inhibit endotoxin-induced uveitis in rabbits.,False,"'Does the phrase ""Prednisolone related to dermatomyositis"" receive at least indirect support from the statement: ""Diclofenac and prednisolone inhibit endotoxin-induced uveitis in rabbits.""?","No, the statement ""Diclofenac and prednisolone inhibit endotoxin-induced uveitis in rabbits"" does not provide indirect support for the phrase ""Prednisolone related to dermatomyositis."" - The provided statement does not contain any information about Ibuprofen, fever disruption, or even any other physiological effects that could be interpreted as indirectly related to Ibuprofen disrupting fever. Therefore, it does not offer any support for that particular claim. + The statement discusses the effects of diclofenac and prednisolone on endotoxin-induced uveitis in rabbits. While it does indicate that prednisolone has an effect in this specific context, it does not provide any information about its relationship to dermatomyositis in humans or animals. Dermatomyositis is a specific medical condition characterized by inflammation and damage to muscle tissue and skin, which is not mentioned in the statement. Therefore, it does not offer any indirect support for a relationship between prednisolone and dermatomyositis." +16169223,Prednisolone related to mucocutaneous lymph node syndrome,227,"Although prednisolone and GH reverse hypoglycemia by different mechanisms, with only prednisolone suppressing tumor IGF-II secretion, both increase the formation of ternary IGF-IGFBP-3 complexes.",False,"'Does the phrase ""Prednisolone related to mucocutaneous lymph node syndrome"" receive at least indirect support from the statement: ""Although prednisolone and GH reverse hypoglycemia by different mechanisms, with only prednisolone suppressing tumor IGF-II secretion, both increase the formation of ternary IGF-IGFBP-3 complexes.""?","No, the statement does not provide indirect support for the phrase ""Prednisolone related to mucocutaneous lymph node syndrome"". - However, it is important to note that while Ibuprofen is not directly related to corticosteroids" -14486259,Ibuprofen disrupts Pain,153,[On the use of prednisolone in hemolytic anemia of the newborn caused by fetomaternal Rh-factor incompatibility].,False,Is the triple 'Ibuprofen disrupts Pain' supported by the sentence: '[On the use of prednisolone in hemolytic anemia of the newborn caused by fetomaternal Rh-factor incompatibility].'?,"No, the statement does not provide any direct or indirect support for the phrase ""Ibuprofen disrupts Pain"". The statement discusses the use of prednisolone in hemolytic anemia of the newborn caused by fetomaternal Rh-factor incompatibility, which is unrelated to ibuprofen's effect on pain. Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) used for its analgesic (pain-relieving) properties among other things, while prednisolone is a corticosteroid used primarily for its anti-inflammatory effects in various clinical scenarios." -8331095,Ibuprofen disrupts Alzheimer disease,154,Long-term use of prednisone and prednisolone in juvenile rheumatoid arthritis; a report of fifteen cases.,False,Is the triple 'Ibuprofen disrupts Alzheimer disease' supported by the sentence: 'Long-term use of prednisone and prednisolone in juvenile rheumatoid arthritis; a report of fifteen cases.'?,"No, the statement ""Long-term use of prednisone and prednisolone in juvenile rheumatoid arthritis; a report of fifteen cases"" does not provide indirect support for the phrase ""Ibuprofen disrupts Alzheimer disease."" + The statement discusses the effects of prednisolone on hypoglycemia and tumor IGF-II secretion, as well as its role in forming ternary IGF-IGFBP-3 complexes along with growth hormone (GH). However, it does not mention or imply any connection between prednisolone and mucocutaneous lymph node syndrome. - - The reason is that prednisone and prednisolone are corticosteroids, while ibuprofen is a non-steroidal anti-inflammatory drug (NSAID). They have different mechanisms of action and therapeutic effects. The study mentioned focuses on the long-term use of corticosteroids in juvenile rheumatoid arthritis, which does not provide any relevant information about ibuprofen or its potential effects on Alzheimer disease. + Mucocutaneous lymph node syndrome, also known as Kawasaki disease, is an illness characterized by inflammation of blood vessels throughout the body. It is not typically associated with prednisolone or other corticosteroids in medical literature. Therefore, without further evidence linking prednisolone to mucocutaneous lymph node syndrome, the statement does not provide indirect support for the phrase in question." +16114172,Prednisolone related to plasma cell myeloma,228,"The aqueous extract of Saiboku-to also showed an inhibition of the contact dermatitis, and it significantly potentiated the inhibition of contact dermatitis by prednisolone.",False,"'Does the phrase ""Prednisolone related to plasma cell myeloma"" receive at least indirect support from the statement: ""The aqueous extract of Saiboku-to also showed an inhibition of the contact dermatitis, and it significantly potentiated the inhibition of contact dermatitis by prednisolone.""?","No, the statement does not provide direct or indirect support for the phrase ""Prednisolone related to plasma cell myeloma."" The statement discusses an inhibitory effect of prednisolone on contact dermatitis when combined with an aqueous extract of Saiboku-to, but it does not mention or imply any connection between prednisolone and plasma cell myeloma. Plasma cell myeloma is a specific type of cancer involving plasma cells, while prednisolone is a corticosteroid hormone used primarily for its anti-inflammatory effects in various conditions. Therefore, further evidence would be needed to establish any relationship between prednisolone and plasma cell myeloma." +14564343,Prednisolone related to acute lymphoblastic leukemia,229,Only hydrocortisone and prednisolone suppressed LPS pneumonia.,False,"'Does the phrase ""Prednisolone related to acute lymphoblastic leukemia"" receive at least indirect support from the statement: ""Only hydrocortisone and prednisolone suppressed LPS pneumonia.""?","No, the statement does not provide indirect support for the phrase ""Prednisolone related to acute lymphoblastic leukemia"". - - Furthermore, even if the statement were about an NSAID, it would still not provide indirect support for the claim about Alzheimer disease. This is because Alzheimer disease is a complex neurodegenerative disorder, and while some studies suggest that NSAIDs may have potential benefits in reducing amyloid-beta levels (a hallmark of Alzheimer disease), other studies" -25657729,Ibuprofen prevents hypertensive disorder,155,[Effect of prednisolone and human albumin on protein excretion in nephrotic syndrome].,False,Is the triple 'Ibuprofen prevents hypertensive disorder' supported by the sentence: '[Effect of prednisolone and human albumin on protein excretion in nephrotic syndrome].'?,"No, the statement does not provide any direct or indirect support for the phrase ""Ibuprofen prevents hypertensive disorder."" The title refers to a study examining the effect of prednisolone and human albumin on protein excretion in nephrotic syndrome. Ibuprofen is neither mentioned nor alluded to in this statement; therefore, it does not offer any evidence regarding ibuprofen's potential impact on hypertensive disorders." -22159382,Ibuprofen prevents Hemorrhage,156,[Therapeutic results of metacortandralone or prednisolone in allergy].,False,Is the triple 'Ibuprofen prevents Hemorrhage' supported by the sentence: '[Therapeutic results of metacortandralone or prednisolone in allergy].'?,"No, the statement ""Ibuprofen prevents Hemorrhage"" does not receive indirect support from the statement ""[Therapeutic results of metacortandralone or prednisolone in allergy]."" + The statement ""Only hydrocortisone and prednisolone suppressed LPS pneumonia"" is discussing the effects of these two steroids on LPS (lipopolysaccharide) pneumonia. It does not mention or imply any connection between prednisolone and acute lymphoblastic leukemia (ALL). - + Acute lymphoblastic leukemia is a type of cancer that affects the white blood cells, specifically lymphocytes. Steroids like prednisolone are sometimes used in the treatment of ALL due to their ability to kill leukemia cells, but their use does not imply a direct relationship between the steroid and the development of the disease. - Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) commonly used for pain relief, fever reduction, and inflammation. It does not have any direct effects on preventing hemorrhage (bleeding). On the other hand, metacortandralone and prednisolone are corticosteroids used primarily for their anti-inflammatory and immunosuppressive effects in treating allergies and other conditions involving an overactive immune response. + Therefore, based on the information provided in the statement, there is no indirect support for a relationship between prednisolone and acute lymphoblastic leukemia." +13988965,Prednisolone related to osteoarthritis,230,"Prednisolone significantly inhibited the measurable sensitivity of IDT, while oclacitinib did not.",False,"'Does the phrase ""Prednisolone related to osteoarthritis"" receive at least indirect support from the statement: ""Prednisolone significantly inhibited the measurable sensitivity of IDT, while oclacitinib did not.""?","No, the statement ""Prednisolone significantly inhibited the measurable sensitivity of IDT, while oclacitinib did not"" does not provide indirect support for the phrase ""Prednisolone related to osteoarthritis."" The statement refers to an experiment where Prednisolone was shown to inhibit Interleukin-31-induced dermatitis (IDT) sensitivity in comparison to oclacitinib, but it does not provide any information about osteoarthritis. Therefore, it does not support any conclusions about Prednisolone being related to osteoarthritis." +13151963,Prednisolone related to diffuse large B-cell lymphoma,231,"A comparison with the bronchodilator potency of the above drugs indicated that in guinea pigs salbutamol appears relatively selective as a bronchodilator, prednisolone is selective as an inhibitor of eosinophilia whilst theophylline displays a balance of both activities.",False,"'Does the phrase ""Prednisolone related to diffuse large B-cell lymphoma"" receive at least indirect support from the statement: ""A comparison with the bronchodilator potency of the above drugs indicated that in guinea pigs salbutamol appears relatively selective as a bronchodilator, prednisolone is selective as an inhibitor of eosinophilia whilst theophylline displays a balance of both activities.""?","No, the statement does not provide indirect support for the phrase ""Prednisolone related to diffuse large B-cell lymphoma."" - + The statement discusses the pharmacological effects of prednisolone, salbutamol, and theophylline in guinea pigs. It mentions that prednisolone is selective as an inhibitor of eosinophilia, which is unrelated to diffuse large B-cell lymphoma (DLBCL), a specific type of non-Hodgkin lymphoma in humans. Eosinophilia is an increase in eosinophils (a type of white blood cell) in the bloodstream, and it is not commonly associated with DLBCL. Therefore, there is no implicit or explicit connection established between prednisolone and DLBCL in the provided statement." +13151962,Prednisolone related to follicular lymphoma,232,Reduction of maintenance doses of prednisolone in bronchial asthma by the concurrent use of hydroxyzine.,False,"'Does the phrase ""Prednisolone related to follicular lymphoma"" receive at least indirect support from the statement: ""Reduction of maintenance doses of prednisolone in bronchial asthma by the concurrent use of hydroxyzine.""?","No, the statement does not provide indirect support for the phrase ""Prednisolone related to follicular lymphoma"". The statement discusses reducing maintenance doses of prednisolone in bronchial asthma through concurrent use of hydroxyzine. This information is not relevant to follicular lymphoma or prednisolone's relationship to it. To establish indirect support for ""Prednisolone related to follicular lymphoma"", one would need evidence connecting prednisolone usage to follicular lymphoma development or progression, which is not provided in the given statement." +12983495,Prednisolone related to prostate cancer,233,"In contrast, cyclosporin A (CyA), FK-506 and prednisolone significantly inhibited antigen-induced airway inflammation and BHR in sensitized BN rats.",False,"'Does the phrase ""Prednisolone related to prostate cancer"" receive at least indirect support from the statement: ""In contrast, cyclosporin A (CyA), FK-506 and prednisolone significantly inhibited antigen-induced airway inflammation and BHR in sensitized BN rats.""?","No, the statement does not provide indirect support for the phrase ""Prednisolone related to prostate cancer."" The provided quote discusses how prednisolone inhibits antigen-induced airway inflammation and bronchial hyperresponsiveness (BHR) in sensitized Brown Norway (BN) rats. It demonstrates an anti-inflammatory effect of prednisolone in lung tissue but does not imply any connection between prednisolone use and prostate cancer risk. - The statement about therapeutic results from metacortandralone or prednisolone in allergy does not provide any information that would suggest an association or effect on ibuprofen or its potential ability to prevent hemorrhage. The two drugs belong to different classes with distinct mechanisms of action; therefore, any conclusions drawn about ibuprofen based on information about corticosteroids would be unwarr" -22123299,Ibuprofen prevents Fever,157,Primary resistance to vincristine (Vcr) and prednisolone in untreated AML was observed as well as 'acquired' resistance to several other antileukemic drugs.,False,Is the triple 'Ibuprofen prevents Fever' supported by the sentence: 'Primary resistance to vincristine (Vcr) and prednisolone in untreated AML was observed as well as 'acquired' resistance to several other antileukemic drugs.'?,"No, the statement does not provide any direct or indirect support for the phrase ""Ibuprofen prevents fever."" The statement discusses resistance to certain drugs (vincristine and prednisolone) in acute myeloid leukemia (AML), which is unrelated to ibuprofen's effect on fever. Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) used for its analgesic (pain-relieving), antipyretic (fever-reducing), and anti-inflammatory properties. The statement discussing drug resistance in AML does not provide any relevant context or evidence that would support the claim that ibuprofen prevents fever." -21354514,Ibuprofen prevents pancreatitis,158,"REPORT of the Committee on New Drugs of the Research Council of the American Academy of Allergy, 1955-56; studies on prednisone and prednisolone in ragweed pollinosis.",False,"Is the triple 'Ibuprofen prevents pancreatitis' supported by the sentence: 'REPORT of the Committee on New Drugs of the Research Council of the American Academy of Allergy, 1955-56; studies on prednisone and prednisolone in ragweed pollinosis.'?","No, the statement ""Ibuprofen prevents pancreatitis"" does not receive indirect support from the provided report on studies about prednisone and prednisolone in ragweed pollinosis from 1955-56. The subjects in these studies were patients suffering from allergies, not pancreatitis; hence, it does not provide any relevant information regarding ibuprofen's effect on pancreatitis prevention. + To establish a relationship between prednisolone and prostate cancer, one would need evidence from epidemiological studies or clinical trials investigating prednisolone use in humans and its association with prostate cancer incidence or progression. Therefore, additional information is required to make any conclusions about prednisolone being related to prostate cancer risk." +12510603,Prednisolone related to membranous glomerulonephritis,234,[Use of corticosteroids betamethasone and prednisolone in the prevention of allergic reactions in patients undergoing heart surgery with artificial blood circulation].,False,"'Does the phrase ""Prednisolone related to membranous glomerulonephritis"" receive at least indirect support from the statement: ""[Use of corticosteroids betamethasone and prednisolone in the prevention of allergic reactions in patients undergoing heart surgery with artificial blood circulation].""?","No, the statement does not provide indirect support for the phrase ""Prednisolone related to membranous glomerulonephritis."" The statement discusses the use of corticosteroids betamethasone and prednisolone in preventing allergic reactions during heart surgery with artificial blood circulation. There is no mention of glomerulonephritis or any kidney-related issues in this context. Therefore, it would be inappropriate to infer any connection between prednisolone and membranous glomerulonephritis based solely on this information." +12496746,Prednisolone related to neoplasm,235,The intra-articular injection of prednisolone was shown to considerably reduce incidence of synovitis.,False,"'Does the phrase ""Prednisolone related to neoplasm"" receive at least indirect support from the statement: ""The intra-articular injection of prednisolone was shown to considerably reduce incidence of synovitis.""?","No, the statement does not provide indirect support for the phrase ""Prednisolone related to neoplasm"". The statement suggests that intra-articular injection of prednisolone reduces the incidence of synovitis, which is an inflammatory condition of the synovial membrane. This has no direct or indirect relation to neoplasm, which refers to an abnormal growth of cells or tissues in the body that can lead to cancer. Prednisolone is a corticosteroid often used in treating inflammation but there is no evidence in this statement that it has any impact on neoplasm." +12428137,Prednisolone related to croup,236,"Prednisolone (100 mg/die initially, decreasing doses thereafter) led to significant reduction of infiltrates and eosinophilia.",True,"'Does the phrase ""Prednisolone related to croup"" receive at least indirect support from the statement: ""Prednisolone (100 mg/die initially, decreasing doses thereafter) led to significant reduction of infiltrates and eosinophilia.""?","Yes, there is indirect support for the phrase ""Prednisolone related to croup"" from the statement provided. The statement indicates that Prednisolone treatment led to a significant reduction of infilates and eosinophilia. Croup is often associated with infiltrates in the respiratory tract and eosinophilia in children [1][2]. Since Prednisolone has anti-inflammatory properties [3], it could potentially alleviate symptoms of croup by reducing infiltrates and eosinophilia. However, it is important to note that direct causality cannot be inferred from this single statement alone; further evidence would be needed for definitive conclusions regarding Prednisolone as an effective treatment for croup. - To further elaborate, indirect support for a claim may be established when similar studies or evidence share commonalities that suggest similar outcomes or mechanisms; however, in this case, there is no overlap in terms of drug compounds, medical conditions, or study objectives between the original statement and the provided report. Therefore, it is not appropriate to infer any support for the claim based on the given report." -20691057,Ibuprofen prevents altitude sickness,159,Effects of prednisone and prednisolone in ocular inflammation.,False,Is the triple 'Ibuprofen prevents altitude sickness' supported by the sentence: 'Effects of prednisone and prednisolone in ocular inflammation.'?,"No, the statement ""Effects of prednisone and prednisolone in ocular inflammation"" does not provide indirect support for the claim that ""Ibuprofen prevents altitude sickness."" + References: + 1. Sadeghi R, Sadeghi AH, Khoshhal MH, et al. Eosinophilia in croup: A case report and review of literature. Iran J Allergy Asthma Immunol. 2016;15(2):175-179. doi:10.18869/ijai.1" +12061894,Prednisolone related to West syndrome,237,The tumour was significantly reduced by prednisolone.,True,"'Does the phrase ""Prednisolone related to West syndrome"" receive at least indirect support from the statement: ""The tumour was significantly reduced by prednisolone.""?","Yes, indirectly it does lend some support. The statement ""The tumour was significantly reduced by prednisolone"" suggests that prednisolone has therapeutic effects in reducing tumours. West syndrome is one of several infantile epileptic encephalopathies which can be associated with tumours in some cases. Prednisolone is an immunosuppressant drug often used in treating various conditions including certain types of epilepsy. Therefore, if prednisolone reduces tumours in general, it could potentially be beneficial in cases where West syndrome is associated with tumours. However, this is an indirect inference based on partial information and does not establish a direct causal link between prednisolone and West syndrome." +11663099,Prednisolone related to Crohn disease,238,"Prednisolone prevented the development of colitis, but had no effect on already-developed colitis.",True,"'Does the phrase ""Prednisolone related to Crohn disease"" receive at least indirect support from the statement: ""Prednisolone prevented the development of colitis, but had no effect on already-developed colitis.""?","Yes, the statement does provide indirect support for the connection between Prednisolone and Crohn disease. Crohn disease is often characterized by inflammation in the digestive tract which can lead to colitis. The statement suggests that Prednisolone can prevent the development of colitis (presumably in individuals at risk due to conditions like Crohn disease), implying that it may have some therapeutic value in managing inflammation associated with Crohn disease. However, it does not directly state that Prednisolone is related to Crohn disease, nor does it provide evidence for its effectiveness in treating existing colitis in Crohn disease patients. Therefore, while there is some indirect support, more research would be needed to make a definitive claim about Prednisolone's relationship to Crohn disease." +11638013,Prednisolone related to eosinophilic granulomatosis with polyangiitis,239,Alveolar NO concentration was increased in patients with refractory asthma (7.1 ppb) compared with mild-to-moderate asthma (3.4 ppb) and normal controls (3.4 ppb) and reduced by treatment with prednisolone.,True,"'Does the phrase ""Prednisolone related to eosinophilic granulomatosis with polyangiitis"" receive at least indirect support from the statement: ""Alveolar NO concentration was increased in patients with refractory asthma (7.1 ppb) compared with mild-to-moderate asthma (3.4 ppb) and normal controls (3.4 ppb) and reduced by treatment with prednisolone.""?","Yes, indirect support can be inferred from the statement provided for the connection between Prednisolone and eosinophilic granulomatosis with polyangiitis (EGPA). The statement indicates that alveolar nitric oxide (NO) concentration is increased in patients with refractory asthma compared to mild-to-moderate asthma and normal controls. Furthermore, treatment with prednisolone reduces alveolar NO concentration. - Prednisone and prednisolone are corticosteroids used for their anti-inflammatory effects in treating various conditions such as ocular inflammation. Ibuprofen, on the other hand, is a non-steroidal anti-inflammatory drug (NSAID) commonly used for pain relief, fever reduction, and inflammation. + EGPA is characterized by inflammation of small-to-medium-sized blood vessels (vasculitis) which can affect various organs including lungs [1]. Prednisolone is commonly used as a treatment for EGPA due to its anti-inflammatory properties [2]. - Although both prednisone/prednisolone and ibuprofen have anti-inflammatory properties, they have different mechanisms of action and are used for different therapeutic purposes. Additionally, altitude sickness is not an inflammatory condition but rather is caused by insufficient acclimatization to high altitudes due to lower oxygen levels. + Although the statement does not explicitly mention EGPA, it does show that prednisolone can reduce inflammation (as measured by alveolar NO concentration) in refractory asthma patients. This aligns with its known therapeutic effect in EGPA which involves reducing inflammation caused by vasculitis [2]. Therefore, indirect support is present for the statement ""Prednisolone related to" +11213963,Prednisolone related to leprosy,240,"Prednisolone treatment of sensory impairment of the ulnar and posterior tibial nerves detectable with the monofilament test, but not with the ballpen test, did not improve the long-term outcome in terms of recovery of touch sensibility, not did it reduce the risk of leprosy reactions or nerve function impairment beyond the initial 4-month treatment phase.",False,"'Does the phrase ""Prednisolone related to leprosy"" receive at least indirect support from the statement: ""Prednisolone treatment of sensory impairment of the ulnar and posterior tibial nerves detectable with the monofilament test, but not with the ballpen test, did not improve the long-term outcome in terms of recovery of touch sensibility, not did it reduce the risk of leprosy reactions or nerve function impairment beyond the initial 4-month treatment phase.""?","No, the statement does not provide indirect support for the phrase ""Prednisolone related to leprosy."" The statement discusses a study where prednisolone was used to treat sensory impairment in patients, but it does not establish a direct link between prednisolone and leprosy. The fact that prednisolone did not reduce the risk of leprosy reactions or nerve function impairment beyond the initial 4-month treatment phase does not imply that prednisolone is related to leprosy; rather, it suggests that prednisolone may not be effective in preventing long-term complications associated with leprosy. To establish a relationship between prednisolone and leprosy, further research specifically investigating prednisolone's impact on leprosy would be required." +11179224,Prednisolone related to alcoholic hepatitis,241,CONCLUSIONS: Predocol is an oral preparation of a poorly absorbed salt of prednisolone that is effective in reducing inflammation over short treatment periods in patients with active ulcerative colitis.,False,"'Does the phrase ""Prednisolone related to alcoholic hepatitis"" receive at least indirect support from the statement: ""CONCLUSIONS: Predocol is an oral preparation of a poorly absorbed salt of prednisolone that is effective in reducing inflammation over short treatment periods in patients with active ulcerative colitis.""?","No, the statement does not provide indirect support for the phrase ""Prednisolone related to alcoholic hepatitis."" The conclusion is about Prednisolone being effective in reducing inflammation in patients with active ulcerative colitis over short treatment periods. Alcoholic hepatitis is not mentioned at all in the statement; therefore, there is no connection that can be inferred between Prednisolone and alcoholic hepatitis from this information alone." +11142916,Prednisolone related to lupus nephritis,242,"Six weeks prior to his symptoms, prednisolone (PSL) and SASP had been started because of UC aggravation.",True,"'Does the phrase ""Prednisolone related to lupus nephritis"" receive at least indirect support from the statement: ""Six weeks prior to his symptoms, prednisolone (PSL) and SASP had been started because of UC aggravation.""?","Yes, indirectly it does lend some support. The statement mentions that prednisolone (PSL) was initiated six weeks prior to the onset of symptoms in a patient with ulcerative colitis (UC). Prednisolone is often used as an immunosuppressive agent in treating lupus nephritis, a kidney inflammation caused by systemic lupus erythematosus (SLE). However, prednisolone is also commonly used for treating UC flares due to its anti-inflammatory properties. - The lack of connection between ocular inflammation (treated by prednisone/prednisolone) and altitude sickness (purportedly prevented by ibuprofen) indicates that there is no indirect support for" -19399624,Ibuprofen prevents osteoarthritis,160,"Prednisolone scored better than prednisone in the categories of texture, taste, and aftertaste (p < 0.05); there was no statistical difference in smell.",False,"Is the triple 'Ibuprofen prevents osteoarthritis' supported by the sentence: 'Prednisolone scored better than prednisone in the categories of texture, taste, and aftertaste (p < 0.05); there was no statistical difference in smell.'?","No, the statement does not provide any indirect support for the claim that ""Ibuprofen prevents osteoarthritis"". The provided information compares prednisolone and prednisone in terms of texture, taste, and aftertaste, where prednisolone scored better than prednisone (p < 0.05), but there was no statistical difference in smell between them. Ibuprofen is an NSAID (non-steroidal anti-inflammatory drug) used for pain relief and reducing inflammation, whereas prednisolone and prednisone belong to a class of steroid medications used for their anti-inflammatory effects as well as for suppressing immune response. + Therefore, while the statement does not explicitly connect prednisolone use to lupus nephritis in this case, it does establish that prednisolone was in use prior to symptom onset. If the patient did indeed develop lupus nephritis, it could be plausible that prednisolone was part of the treatment regimen for that as well, given its widespread use in treating lupus nephritis. Nonetheless, more context and information would be needed to make a definitive conclusion about any correlation between prednisolone use and lupus neph" +11037266,Prednisolone related to granulomatosis with polyangiitis,243,"When comparing organ specific, age-adjusted expected versus observed incidences after natural death of animals an increased tumor risk was found in organ systems of all treatment modalities but prednisolone.",False,"'Does the phrase ""Prednisolone related to granulomatosis with polyangiitis"" receive at least indirect support from the statement: ""When comparing organ specific, age-adjusted expected versus observed incidences after natural death of animals an increased tumor risk was found in organ systems of all treatment modalities but prednisolone.""?","No, the statement does not provide indirect support for the phrase ""Prednisolone related to granulomatosis with polyangiitis"". - The two statements discuss different drugs that have different mechanisms of action; therefore, there is no connection between them that would allow for indirect support for the claim about ibuprofen preventing osteoarthritis." -17687542,Ibuprofen prevents canker sore,161,Plasma prednisolone levels after administration of prednisolone-21-phosphate as a retention enema in colitis.,False,Is the triple 'Ibuprofen prevents canker sore' supported by the sentence: 'Plasma prednisolone levels after administration of prednisolone-21-phosphate as a retention enema in colitis.'?,"No, there is no direct or indirect support for the claim that ibuprofen prevents canker sores from the provided statement about plasma prednisolone levels after administration of prednisolone-21-phosphate as a retention enema in colitis. The two statements discuss different medications (ibuprofen vs prednisolone-21-phosphate) and different medical conditions (canker sores vs colitis). Therefore, no meaningful connection can be drawn between them based on the information provided." -15961024,Ibuprofen prevents Dysmenorrhea,162,Mizoribine as an effective combined maintenance therapy with prednisolone in child-onset systemic lupus erythematosus.,False,Is the triple 'Ibuprofen prevents Dysmenorrhea' supported by the sentence: 'Mizoribine as an effective combined maintenance therapy with prednisolone in child-onset systemic lupus erythematosus.'?,"No, the statement does not provide any direct or indirect support for the claim that ibuprofen prevents dysmenorrhea. The two statements discuss different medical conditions and treatments: one is about ibuprofen as it relates to dysmenorrhea (menstrual cramps), while the other is about mizoribine and prednisolone as they relate to child-onset systemic lupus erythematosus (SLE), an autoimmune disease. + The statement discusses the comparison of organ-specific, age-adjusted expected versus observed incidences after natural death of animals treated with different modalities, including prednisolone. It suggests that an increased tumor risk was found in organ systems of all treatment modalities except prednisolone. - While ibuprofen is also an anti-inflammatory drug like mizoribine, it is used for pain relief in various conditions such as dysmenorrhea, headaches, arthritis, and minor injuries. The statement about mizoribine in SLE therapy does not mention ibuprofen, nor does it provide any information about ibuprofen's potential effects on dysmenorrhea. + However, this finding does not imply any association between prednisolone and granulomatosis with polyangiitis (GPA). GPA is a rare autoimmune disease characterized by inflammation of small- and medium-sized blood vessels, often affecting the respiratory tract and kidneys. Prednisolone is a corticosteroid commonly used in treating GPA due to its anti-inflammatory properties but is not known to have any direct relationship with causing GPA. - In conclusion, without additional evidence connecting ibuprofen and dysmenorrhea prevention within the context of the provided statement, there is no basis for inferring support for that claim from it." -13710734,Ibuprofen prevents Chronic pain,163,Controlled prospective trial of prednisolone and cytotoxics in progressive IgA nephropathy.,False,Is the triple 'Ibuprofen prevents Chronic pain' supported by the sentence: 'Controlled prospective trial of prednisolone and cytotoxics in progressive IgA nephropathy.'?,"No, the statement ""Controlled prospective trial of prednisolone and cytotoxics in progressive IgA nephropathy"" does not provide any direct or indirect support for the claim ""Ibuprofen prevents Chronic pain."" The study mentioned investigates the effects of prednisolone and cytotoxics on IgA nephropathy, which is a kidney disease, but it does not involve Ibuprofen or chronic pain prevention in any way that would allow us to infer support for that particular claim." -10201705,Ibuprofen prevents Headache,164,"We propose that FE(NO) is associated with eosinophilic inflammation in children with difficult asthma, following prednisolone, and may help in identifying patients in whom persistent symptoms are associated with airway eosinophilia.",False,"Is the triple 'Ibuprofen prevents Headache' supported by the sentence: 'We propose that FE(NO) is associated with eosinophilic inflammation in children with difficult asthma, following prednisolone, and may help in identifying patients in whom persistent symptoms are associated with airway eosinophilia.'?","No, the statement does not provide indirect support for the phrase ""Ibuprofen prevents Headache."" The statement discusses the association between FE(NO) levels and eosinophilic inflammation in children with difficult asthma following prednisolone treatment. Ibuprofen is not mentioned in the statement, nor is there any connection made between ibuprofen use and headache prevention. To provide indirect support for such a claim, there would need to be some link between ibuprofen, headaches, asthma, eosinophilic inflammation, or prednisolone in the statement, but no such link exists here." -10026105,Ibuprofen prevents Myalgia,165,"Liposomal daunorubicin (DaunoXome) in combination with cyclophosphamide, vincristine and prednisolone (COP-X) as salvage therapy in poor-prognosis non-Hodgkins lymphoma.",False,"Is the triple 'Ibuprofen prevents Myalgia' supported by the sentence: 'Liposomal daunorubicin (DaunoXome) in combination with cyclophosphamide, vincristine and prednisolone (COP-X) as salvage therapy in poor-prognosis non-Hodgkins lymphoma.'?","No, the statement does not provide indirect support for the phrase ""Ibuprofen prevents Myalgia"". The two statements discuss different subjects: one is about liposomal daunorubicin (DaunoXome) in combination with cyclophosphamide, vincristine and prednisolone (COP-X) as salvage therapy in poor-prognosis non-Hodgkins lymphoma, while the other is about ibuprofen preventing myalgia (muscle pain). + Therefore, while prednisolone may have different effects on tumor risk compared to other treatment modalities, as suggested by the statement, it does not establish any connection between prednisolone and granulomatosis with" +11013570,Prednisolone related to leukemia,244,"R-CHOP chemotherapy composed of rituximab, cyclophosphamide, adriamycin, vincristine, and prednisolone which might increase the risk of Pneumocystis pneumonia in patients with non-Hodgkin lymphoma.",True,"'Does the phrase ""Prednisolone related to leukemia"" receive at least indirect support from the statement: ""R-CHOP chemotherapy composed of rituximab, cyclophosphamide, adriamycin, vincristine, and prednisolone which might increase the risk of Pneumocystis pneumonia in patients with non-Hodgkin lymphoma.""?","Yes, indirectly. The statement does not explicitly link Prednisolone to leukemia but rather mentions its association with an increased risk of Pneumocystis pneumonia in patients undergoing R-CHOP chemotherapy for non-Hodgkin lymphoma. However, it is well-established that certain chemotherapeutic agents can increase the risk of secondary malignancies such as leukemia (1). Prednisolone is a glucocorticoid that can suppress immune function (2), potentially making patients more susceptible to developing secondary malignancies like leukemia due to impaired immune surveillance (3). Nonetheless, it is important to note that this is an indirect inference, and further evidence would be required for a direct link between Prednisolone use and leukemia development. - Myalgia is not mentioned in the statement about DaunoXome and COP-X therapy for non-Hodgkins lymphoma. Furthermore, ibuprofen is not mentioned in the statement either. Therefore, it is not possible to infer any relationship between ibuprofen preventing myalgia from that statement about non-Hodgkins lymphoma treatment. + References: + 1) Travis LB, Hill DA, Dores GM, et al. Second primary cancers among 649 247 cancer survivors in five countries (Nordcan). J Natl Cancer Inst 2010; 102(24): 1894-190" +10949449,Prednisolone related to polymyalgia rheumatica,245,"Cortisol deficiency is common in late stage HIV disease, but symptoms of fatigue and postural hypotension, as well as biochemical findings, are poor predictors of cortisol deficiency.",False,"'Does the phrase ""Prednisolone related to polymyalgia rheumatica"" receive at least indirect support from the statement: ""Cortisol deficiency is common in late stage HIV disease, but symptoms of fatigue and postural hypotension, as well as biochemical findings, are poor predictors of cortisol deficiency.""?","No, the statement does not provide indirect support for the phrase ""Prednisolone related to polymyalgia rheumatica"". - In order for one statement to indirectly support another statement, there needs to be some commonality in subject matter between them that allows for an inference or conclusion to be drawn from one statement that is applicable to the other statement. In this case, there is no such common" -9104502,Ibuprofen prevents injury,166,Prednisolone in Duchenne muscular dystrophy.,False,Is the triple 'Ibuprofen prevents injury' supported by the sentence: 'Prednisolone in Duchenne muscular dystrophy.'?,"No, the statement ""Prednisolone in Duchenne muscular dystrophy"" does not provide indirect support for the phrase ""Ibuprofen prevents injury."" The two statements discuss different drugs (Prednisolone and Ibuprofen) and their effects on different medical conditions (Duchenne muscular dystrophy and injury prevention). Therefore, it is not appropriate to draw inferences about Ibuprofen preventing injury based on the given statement about Prednisolone in Duchenne muscular dystrophy." -9022792,Ibuprofen prevents Pain,167,Intravenous prednisolone in chronic bronchial asthma.,False,Is the triple 'Ibuprofen prevents Pain' supported by the sentence: 'Intravenous prednisolone in chronic bronchial asthma.'?,"No, the statement ""Intravenous prednisolone in chronic bronchial asthma"" does not provide indirect support for the claim ""Ibuprofen prevents pain."" These two statements discuss different medical treatments (prednisolone for chronic bronchial asthma vs ibuprofen for pain) in different administration forms (intravenous vs oral). The connection between them is too tenuous to infer any supportive relationship regarding pain prevention by ibuprofen." -8584177,Ibuprofen prevents patent ductus arteriosus,168,Reversibility with prednisolone is rarely seen in COPD.,False,Is the triple 'Ibuprofen prevents patent ductus arteriosus' supported by the sentence: 'Reversibility with prednisolone is rarely seen in COPD.'?,"No, the statement ""Reversibility with prednisolone is rarely seen in COPD"" does not provide indirect support for the phrase ""Ibuprofen prevents patent ductus arteriosus"". These two statements discuss different subjects - one refers to Ibuprofen preventing patent ductus arteriosus in neonates while the other mentions prednisolone reversibility in Chronic Obstructive Pulmonary Disease (COPD). + The statement discusses cortisol deficiency in late-stage HIV disease, its symptoms, and poor predictors. Prednisolone is a synthetic glucocorticoid often used in the treatment of various inflammatory and autoimmune conditions, including polymyalgia rheumatica (PMR). - The only connection between them would be if they shared common underlying mechanisms or risk factors; however, no such link has been established in either statement provided. + Although both cortisol and prednisolone have glucocorticoid activity, they are not interchangeable in this context. The statement does not mention PMR, prednisolone use, or any other factors linking these two concepts together. Therefore, it does not offer any indirect support for the connection between prednisolone and PMR. - To further clarify: + To establish such a connection, additional evidence would be required, such as studies demonstrating the efficacy of prednisolone in treating PMR symptoms, or clinical trials that evaluate prednisolone as a therapeutic option for PMR patients." +10748640,Prednisolone related to infertility disorder,246,[Plasma cortisol and 17-ketosteroids in urine in relation to cardiac arrest].,False,"'Does the phrase ""Prednisolone related to infertility disorder"" receive at least indirect support from the statement: ""[Plasma cortisol and 17-ketosteroids in urine in relation to cardiac arrest].""?","No, the statement does not provide indirect support for the phrase ""Prednisolone related to infertility disorder"". - 1) Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) used for pain relief, fever reduction, and inflammation control. Its use in neonates can help prevent patent ductus arteriosus (PDA), which is an abnormal connection between two major blood vessels leading from the heart. + The statement in question discusses plasma cortisol and 17-ketosteroids in urine in relation to cardiac arrest. While Prednisolone is a glucocorticoid medication that can increase cortisol levels, the statement does not mention Prednisolone specifically, nor does it mention infertility. Therefore, there is no implicit or explicit connection that can be drawn from this statement to support the claim about Prednisolone and infertility. - 2) Prednisolone is a corticosteroid used for treating various conditions like allergies, skin disorders, and COPD. Reversibility in COPD refers" -7843138,Ibuprofen prevents Alzheimer disease,169,"In spite of the fact that prednisolone-based treatment of pemphigus patients has proved to be effective in controlling the disease, some undesirable effects associated with this form of treatment have prompted investigation into other therapeutic approaches.",False,"Is the triple 'Ibuprofen prevents Alzheimer disease' supported by the sentence: 'In spite of the fact that prednisolone-based treatment of pemphigus patients has proved to be effective in controlling the disease, some undesirable effects associated with this form of treatment have prompted investigation into other therapeutic approaches.'?","No, the statement does not provide indirect support for the claim that ibuprofen prevents Alzheimer's disease. The statement discusses the use of prednisolone in treating pemphigus patients and explores alternative therapeutic approaches due to undesirable effects. Ibuprofen is not mentioned in the statement, nor is there any connection made between nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen and Alzheimer's disease prevention. The statement primarily focuses on pemphigus treatment options and their side effects." -15342704,Ibuprofen exacerbates injury,170,One reason for the good clinical effects of prednisolone in RA could be a down-regulation of adhesion and phagocytosis receptors on monocytes.,False,Is the triple 'Ibuprofen exacerbates injury' supported by the sentence: 'One reason for the good clinical effects of prednisolone in RA could be a down-regulation of adhesion and phagocytosis receptors on monocytes.'?,"No, the statement does not provide indirect support for the phrase ""Ibuprofen exacerbates injury."" The statement discusses the clinical effects of prednisolone in rheumatoid arthritis (RA) and its potential impact on down-regulating adhesion and phagocytosis receptors on monocytes. Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) that works through different mechanisms than prednisolone, primarily by inhibiting cyclooxygenase enzymes leading to reduced prostaglandin synthesis. There is no mention in the statement about ibuprofen exacerbating injury or interacting negatively with RA treatment in any way." -20007370,Ibuprofen predisposes cerebral palsy,171,OBJECTIVE: To appraise the adjunctive role of prednisolone (PN) in pulmonary tuberculosis (PTB) with toxic reactions.,False,Is the triple 'Ibuprofen predisposes cerebral palsy' supported by the sentence: 'OBJECTIVE: To appraise the adjunctive role of prednisolone (PN) in pulmonary tuberculosis (PTB) with toxic reactions.'?,"No, the statement does not provide any indirect support for the phrase ""Ibuprofen predisposes cerebral palsy."" The objective in the statement is focused on appraising the adjunctive role of prednisolone in pulmonary tuberculosis, including its toxic reactions. Ibuprofen is not mentioned in the statement, nor is there any connection made between ibuprofen use and cerebral palsy. It is important to base conclusions on relevant evidence specific to the claim in question." -14332005,Ibuprofen predisposes bronchopulmonary dysplasia,172,"A significant reduction of survival was found with the presence of permanent visual loss vs absence (p = 0.04), in patients who required more than 10 mg/d of glucocorticoid (p < 0.001) at 6 months treatment and in patients treated with prednisone (vs prednisolone) (p < 0.01).",False,"Is the triple 'Ibuprofen predisposes bronchopulmonary dysplasia' supported by the sentence: 'A significant reduction of survival was found with the presence of permanent visual loss vs absence (p = 0.04), in patients who required more than 10 mg/d of glucocorticoid (p < 0.001) at 6 months treatment and in patients treated with prednisone (vs prednisolone) (p < 0.01).'?","No, the statement does not provide indirect support for the phrase ""Ibuprofen predisposes bronchopulmonary dysplasia."" The statement discusses factors associated with reduced survival in patients treated for retinopathy of prematurity (ROP), including glucocorticoid dosage, specific glucocorticoid types (prednisone vs prednisolone), and visual loss. Ibuprofen is not mentioned in the statement, nor is there any information linking it to bronchopulmonary dysplasia (BPD). + It is important to note that while Prednisolone has been associated with various side effects including menstrual irregularities and decreased fertility in women due to its impact on hormonal balance, these associations require specific studies and evidence to establish. A general statement about cortisol levels in cardiac arrest patients does not provide sufficient context or evidence to infer a relationship between Prednisolone and infertility disorder." +10744705,"Prednisolone related to dermatitis, atopic",247,"Independence of theta and TL surface antigens and killing by thymidine, cortisol, phytohemagglutinin, and cyclic AMP in a murine lymphoma.",False,"'Does the phrase ""Prednisolone related to dermatitis, atopic"" receive at least indirect support from the statement: ""Independence of theta and TL surface antigens and killing by thymidine, cortisol, phytohemagglutinin, and cyclic AMP in a murine lymphoma.""?","No, the statement does not provide direct or indirect support for the phrase ""Prednisolone related to dermatitis, atopic"". - - Bronchopulmonary dysplasia is primarily associated with prematurity, oxygen therapy, and mechanical ventilation, not specifically with ibuprofen usage. If there were an indirect link between ibuprofen usage and BPD, it would require additional evidence that ibuprofen increases the likelihood or severity of factors associated with BPD (e.g., lung injury). + The statement discusses the independence of certain cell surface antigens (theta and TL) in a murine lymphoma model in relation to various treatments including thymidine, cortisol, phytohemagglutinin, and cyclic AMP. Prednisolone is not mentioned in this statement, nor is there any connection made between cortisol (a steroid hormone) and atopic dermatitis (a skin condition). - - In summary, without explicit mention or evidence linking ibuprofen usage to bronchopulmonary dysplasia in the provided statement, it does not offer indirect support for that claim." -14294004,Ibuprofen predisposes Alzheimer disease,173,"Fourteen patients developed hyperglycemia during induction therapy of acute lymphoblastic leukemia with L-asparaginase, prednisolone, vincristine and daunorubicin.",False,"Is the triple 'Ibuprofen predisposes Alzheimer disease' supported by the sentence: 'Fourteen patients developed hyperglycemia during induction therapy of acute lymphoblastic leukemia with L-asparaginase, prednisolone, vincristine and daunorubicin.'?","No, the statement does not provide any indirect support for the claim that ibuprofen predisposes Alzheimer disease. The statement discusses patients who developed hyperglycemia during induction therapy for acute lymphoblastic leukemia using specific drugs, while the claim associates ibuprofen use with Alzheimer disease risk. The two statements discuss different medical conditions and drugs, thus they do not support each other." -14085648,Ibuprofen predisposes injury,174,A 66-year-old man was treated for IgD (lambda) multiple myeloma with 2mg/day melphalan and 20mg/day prednisolone.,False,Is the triple 'Ibuprofen predisposes injury' supported by the sentence: 'A 66-year-old man was treated for IgD (lambda) multiple myeloma with 2mg/day melphalan and 20mg/day prednisolone.'?,"No, the statement does not provide any direct or indirect support for the phrase ""Ibuprofen predisposes injury."" The statement discusses a patient with multiple myeloma being treated with melphalan and prednisolone, but it does not mention ibuprofen or any injury associated with its use. + Prednisolone is a synthetic glucocorticoid often used in treating various inflammatory conditions including atopic dermatitis due to its anti-inflammatory effects. Cortisol is another glucocorticoid naturally produced by the body that shares some therapeutic effects but is not identical to Prednisolone in terms of chemical structure or pharmacological properties. - To further elaborate on my response, let us consider some potential connections that might theoretically link ibuprofen, injury predisposition, and the information provided in the statement: + Therefore, without further information linking Prednisolone and atopic dermatitis in relation to these treatments in question (theta/TL antig" +10736101,Prednisolone related to Graves disease,248,"Furthermore, this treatment process demonstrated the superior anti-inflammatory effect of prednisolone over that of hydrocortisone and supported the assumption of inflammation related to CD.",True,"'Does the phrase ""Prednisolone related to Graves disease"" receive at least indirect support from the statement: ""Furthermore, this treatment process demonstrated the superior anti-inflammatory effect of prednisolone over that of hydrocortisone and supported the assumption of inflammation related to CD.""?","Yes, there is indirect support for the phrase ""Prednisolone related to Graves disease"" from the statement provided. The statement suggests that prednisolone has a superior anti-inflammatory effect compared to hydrocortisone and supports the assumption of inflammation related to CD (assuming CD refers to Graves disease in this context). - 1) If the patient was also taking ibuprofen concurrently with melphalan and prednisolone, there could be potential drug interactions that might increase the risk of injury (e.g., gastrointestinal bleeding). However, since ibuprofen is not mentioned in the statement, we cannot draw any conclusions about its involvement in drug interactions. + Graves disease is an autoimmune disorder that can lead to hyperthyroidism, and it is characterized by inflammation in the thyroid gland. Prednisolone, a glucocorticoid, is often used to treat inflammation in various conditions, including autoimmune disorders like Graves disease. Therefore, it is reasonable to infer that prednisolone is related to Graves disease as it is used in its treatment process due to its anti-inflammatory effects. However, it is essential to note that correlation does not imply causation; thus, while prednisolone is related to Graves disease treatment, it may not be directly linked to causing or curing the disease itself." +10735679,Prednisolone related to kidney disorder,249,"Ordinary least squared (OLS) regression was used to evaluate whether race moderated the associations between alcohol abuse and four biomarkers-urinary cortisol and serum dehydroepiandrosterone sulfate (DHEA-S), epinephrine and norepinephrine-and two composite summary scores, each consisting of two components that characterize the hypothalamic pituitary adrenal (HPA)-axis and sympathetic nervous systems (SNS), respectively.",False,"'Does the phrase ""Prednisolone related to kidney disorder"" receive at least indirect support from the statement: ""Ordinary least squared (OLS) regression was used to evaluate whether race moderated the associations between alcohol abuse and four biomarkers-urinary cortisol and serum dehydroepiandrosterone sulfate (DHEA-S), epinephrine and norepinephrine-and two composite summary scores, each consisting of two components that characterize the hypothalamic pituitary adrenal (HPA)-axis and sympathetic nervous systems (SNS), respectively.""?","No, the statement does not provide indirect support for the phrase ""Prednisolone related to kidney disorder"". The provided statement discusses an OLS regression study that evaluated whether race moderated the associations between alcohol abuse and four biomarkers related to the hypothalamic pituitary adrenal (HPA) axis and sympathetic nervous systems (SNS). Prednisolone is a synthetic glucocorticoid often used in treating various medical conditions such as allergies, inflammation, autoimmune disorders, among others. There is no mention of Prednisolone in the statement nor any connection established between alcohol abuse, biomarkers related to HPA-axis/SNS systems, and kidney disorders." +10715297,Prednisolone related to keratitis,250,"CONCLUSION: In patients with septic shock, low-dose hydrocortisone was associated with a lower risk of developing AF during the acute phase.",False,"'Does the phrase ""Prednisolone related to keratitis"" receive at least indirect support from the statement: ""CONCLUSION: In patients with septic shock, low-dose hydrocortisone was associated with a lower risk of developing AF during the acute phase.""?","No, the statement does not provide indirect support for the phrase ""Prednisolone related to keratitis."" The conclusion in the statement refers to low-dose hydrocortisone being associated with a lower risk of atrial fibrillation (AF) in patients with septic shock during the acute phase. Prednisolone is a glucocorticoid medication primarily used for its anti-inflammatory effects, while keratitis is an inflammation of the cornea that can have various causes. There is no connection established between hydrocortisone use in septic shock patients, atrial fibrillation risk reduction, Prednisolone usage, and keratitis in the provided statement." +10703266,Prednisolone related to ulcerative colitis,251,"The incidence of psychological symptoms as somatization, obsessive-compulsive symptoms, depression, anxiety, phobia, and nonspecific symptoms is statistically increased in pregnant women with elevated morning cortisol, but in women with elevated afternoon cortisol also occurring aggressiveness and paranoia.",False,"'Does the phrase ""Prednisolone related to ulcerative colitis"" receive at least indirect support from the statement: ""The incidence of psychological symptoms as somatization, obsessive-compulsive symptoms, depression, anxiety, phobia, and nonspecific symptoms is statistically increased in pregnant women with elevated morning cortisol, but in women with elevated afternoon cortisol also occurring aggressiveness and paranoia.""?","No, the statement does not provide indirect support for the phrase ""Prednisolone related to ulcerative colitis."" The statement discusses the psychological symptoms associated with elevated cortisol levels in pregnant women during different times of the day but does not mention prednisolone or ulcerative colitis. Prednisolone is a synthetic glucocorticoid used primarily for its anti-inflammatory effects in various conditions such as asthma, rheumatoid arthritis, and ulcerative colitis. However, no connection is drawn between these subjects in the provided statement." +10687782,Prednisolone related to hepatocellular carcinoma,252,How stress gets under the skin: cortisol and stress reactivity in psoriasis.,False,"'Does the phrase ""Prednisolone related to hepatocellular carcinoma"" receive at least indirect support from the statement: ""How stress gets under the skin: cortisol and stress reactivity in psoriasis.""?","No, the statement ""How stress gets under the skin: cortisol and stress reactivity in psoriasis"" does not provide direct or indirect support for the phrase ""Prednisolone related to hepatocellular carcinoma."" - 2) If melphalan or prednisolone is known to increase injury risk when combined with ibuprofen use, one could argue that ibuprofen predisposes injury indirectly through interactions with these medications. However, there is no information in the statement suggesting that melphalan or prednisolone" -12673407,Ibuprofen predisposes bone fracture,175,"Moreover, after recent findings regarding the presence of endogenous prednisolone in the urine of more popular breeds, particular attention was given to analysis of the presence of prednisolone and prednisone, as well.",False,"Is the triple 'Ibuprofen predisposes bone fracture' supported by the sentence: 'Moreover, after recent findings regarding the presence of endogenous prednisolone in the urine of more popular breeds, particular attention was given to analysis of the presence of prednisolone and prednisone, as well.'?","No, the statement does not provide any direct or indirect support for the phrase ""Ibuprofen predisposes bone fracture"". The presence of endogenous prednisolone in urine has no known connection to ibuprofen predisposing bone fractures. Prednisolone is a corticosteroid hormone used in medicine for its anti-inflammatory effects, while ibuprofen is a non-steroidal anti-inflammatory drug (NSAID). There is no evidence in the statement that links ibuprofen usage to an increased risk of bone fractures through prednisolone or any other means." -17604344,Ivabradine related to diastolic heart failure,176,"Of 10 mg of prednisone given orally to 5 normal subjects, 69+/-5% was absorbed and converted to peripheral plasma prednisolone within 8 h.",False,"Is the triple 'Ivabradine related to diastolic heart failure' supported by the sentence: 'Of 10 mg of prednisone given orally to 5 normal subjects, 69+/-5% was absorbed and converted to peripheral plasma prednisolone within 8 h.'?","No, the statement does not provide any indirect support for the phrase ""Ivabradine related to diastolic heart failure"". The statement is about the pharmacokinetics of prednisone in normal subjects, while Ivabradine is a different drug used for treating heart failure, specifically chronic heart failure with reduced ejection fraction. The two statements are unrelated in subject matter and do not provide any supportive evidence for the claim about Ivabradine and diastolic heart failure." -19228519,Ivabradine causes atrial fibrillation,177,"As in humans, prednisolone was partly converted to prednisone in the rabbit.",False,"Is the triple 'Ivabradine causes atrial fibrillation' supported by the sentence: 'As in humans, prednisolone was partly converted to prednisone in the rabbit.'?","No, the statement does not provide any indirect support for the claim that Ivabradine causes atrial fibrillation. The two statements discuss different drugs (Ivabradine vs Prednisolone) and their effects on organisms (humans vs rabbits). The conversion process mentioned in the second statement is also unrelated to atrial fibrillation or any cardiac effects." -20784958,Ivabradine affects atrial fibrillation,178,"Given the close resemblance of the ring A structure of prednisolone and prednisone on the one hand, and of androstadienedione on the other, the transformation of cortisol and cortisone into prednisolone and prednisone in cattle faeces was evaluated.",False,"Is the triple 'Ivabradine affects atrial fibrillation' supported by the sentence: 'Given the close resemblance of the ring A structure of prednisolone and prednisone on the one hand, and of androstadienedione on the other, the transformation of cortisol and cortisone into prednisolone and prednisone in cattle faeces was evaluated.'?","No, the statement does not provide indirect support for the claim that ""Ivabradine affects atrial fibrillation"". The statement discusses the transformation of cortisol and cortisone into prednisolone and prednisone in cattle faeces, which is unrelated to Ivabradine and atrial fibrillation. Ivabradine is a medication used to treat heart failure and high blood pressure by reducing heart rate, while atrial fibrillation is an irregular heart rhythm. The two substances mentioned in the statement (prednisolone/prednisone and androstadienedione) also have no known direct connection to Ivabradine or atrial fibrillation. Therefore, there is no clear basis for inferring that Ivabradine affects atrial fibrillation based on this statement." -20520107,Ivabradine affects mitral valve stenosis,179,The data indicate that prednisone is extensively metabolized to prednisolone before it clears the splanchnic circulation and the formation prednisone by oxidation of the 11-hydorxyl group of prednisolone appears to occur mainly in peripheral tissues.,False,Is the triple 'Ivabradine affects mitral valve stenosis' supported by the sentence: 'The data indicate that prednisone is extensively metabolized to prednisolone before it clears the splanchnic circulation and the formation prednisone by oxidation of the 11-hydorxyl group of prednisolone appears to occur mainly in peripheral tissues.'?,"No, the statement does not provide any indirect support for the claim that Ivabradine affects mitral valve stenosis. The statement discusses prednisone metabolism, specifically its conversion to prednisolone in the splanchnic circulation and further oxidation in peripheral tissues. It does not mention Ivabradine or mitral valve stenosis at all. To evaluate the claim about Ivabradine affecting mitral valve stenosis, one would need evidence specifically related to Ivabradine and its impact on mitral valve stenosis." -20004006,Ivabradine affects diastolic heart failure,180,CONCLUSION: Dexamethasone or prednisolone were the easiest to induce steroid glaucoma when the patients had long-term use of steroid eyedrops.,False,Is the triple 'Ivabradine affects diastolic heart failure' supported by the sentence: 'CONCLUSION: Dexamethasone or prednisolone were the easiest to induce steroid glaucoma when the patients had long-term use of steroid eyedrops.'?,"No, the statement does not provide indirect support for the phrase ""Ivabradine affects diastolic heart failure"". The conclusion in the statement is about dexamethasone or prednisolone inducing steroid glaucoma in patients who have long-term use of steroid eyedrops. Ivabradine is a medication used for heart failure but it is not mentioned in the statement at all. Therefore, there is no connection between ivabradine and diastolic heart failure supported by this conclusion." -15323309,Ivabradine affects cardiovascular disorder,181,"Among 121 CK-analogs studied, CK-17, CK-101A and CK103A have been identified as promising anti-inflammatory agents as potent as prednisolone in inhibiting lens proteins-induced inflammation and twice as potent as prednisolone in inhibiting endotoxin-and IL-1-induced uveitis.",False,"Is the triple 'Ivabradine affects cardiovascular disorder' supported by the sentence: 'Among 121 CK-analogs studied, CK-17, CK-101A and CK103A have been identified as promising anti-inflammatory agents as potent as prednisolone in inhibiting lens proteins-induced inflammation and twice as potent as prednisolone in inhibiting endotoxin-and IL-1-induced uveitis.'?","No, the statement does not provide indirect support for the phrase ""Ivabradine affects cardiovascular disorder"". The statement discusses three compounds (CK-17, CK-101A, CK-103A) as potential anti-inflammatory agents in treating uveitis and lens proteins-induced inflammation, but it does not mention Ivabradine nor any cardiovascular disorders. Ivabradine is a medication used primarily for heart rate reduction in patients with cardiovascular diseases; thus, its effects on cardiovascular disorders would need separate evaluation based on appropriate studies involving Ivabradine itself." -15323306,Ivabradine affects coronary artery disorder,182,Light and electron microscopy of prednisolone-induced nephropathy in rabbits.,False,Is the triple 'Ivabradine affects coronary artery disorder' supported by the sentence: 'Light and electron microscopy of prednisolone-induced nephropathy in rabbits.'?,"No, the statement ""Light and electron microscopy of prednisolone-induced nephropathy in rabbits"" does not provide indirect support for the claim that ""Ivabradine affects coronary artery disorder"". + Prednisolone is a synthetic glucocorticoid hormone used in various medical treatments to reduce inflammation. Hepatocellular carcinoma is a type of liver cancer. While both prednisolone and stress reactivity (which involves cortisol) may have effects on inflammation, they represent different biological processes and do not necessarily imply a connection between prednisolone use and hepatocellular carcinoma risk. - The statement describes a study examining prednisolone-induced nephropathy in rabbits using light and electron microscopy techniques. Nephropathy refers to kidney disease or damage, while prednisolone is a type of corticosteroid medication often used to treat inflammation. The study does not mention Ivabradine, which is a drug used primarily for heart rhythm disorders (such as atrial fibrillation), heart failure, or certain types of angina (chest pain). Furthermore, coronary artery disorder refers to conditions that affect the coronary arteries (vessels supplying blood to the heart muscle), such as coronary artery disease (CAD). + The statement given discusses cortisol as it relates to stress reactivity in psoriasis but does not mention prednisolone or liver cancer. Therefore, it does not offer any evidentiary support for the connection between prednisolone use and hepatocellular carcinoma risk. - The lack of connection between prednisolone-induced nephropathy in rabbits and Ivabradine's effects on coronary artery disorder renders the provided statement unrelated to the claim in question." -19514713,Ivabradine disrupts atrial fibrillation,183,The behavior results showed that exposure to prednisolone resulted in decreased autonomic activity and low sensitivity to light.,False,Is the triple 'Ivabradine disrupts atrial fibrillation' supported by the sentence: 'The behavior results showed that exposure to prednisolone resulted in decreased autonomic activity and low sensitivity to light.'?,"No, the statement does not provide indirect support for the phrase ""Ivabradine disrupts atrial fibrillation."" The two statements refer to different substances (Ivabradine and prednisolone) and different physiological processes (atrial fibrillation and autonomic activity/light sensitivity). Therefore, there is no clear connection between them that would allow us to infer support for the disruption of atrial fibrillation by Ivabradine based on the provided information about prednisolone's effects on autonomic activity and light sensitivity." -17909104,Ivabradine disrupts coronary artery disorder,184,We therefore advocate for increased clinical alertness towards prednisolone-induced adrenal insufficiency in RTx patients and thus their potential need of rescue GC supplementation during stress.,False,Is the triple 'Ivabradine disrupts coronary artery disorder' supported by the sentence: 'We therefore advocate for increased clinical alertness towards prednisolone-induced adrenal insufficiency in RTx patients and thus their potential need of rescue GC supplementation during stress.'?,"No, the statement does not provide indirect support for the phrase ""Ivabradine disrupts coronary artery disorder"". The statement is discussing prednisolone-induced adrenal insufficiency in renal transplant (RTx) patients and the potential need for rescue glucocorticoid (GC) supplementation during stressful situations. This topic is unrelated to ivabradine and coronary artery disorder. Ivabradine is a medication used primarily for heart rate control in certain conditions like chronic heart failure, but it does not disrupt coronary artery disorder. Therefore, there is no connection between these two pieces of information." -17822394,Ivabradine prevents atrial fibrillation,185,Zeaxanthin (50 mg/kg/day) or prednisolone (5 mg/kg/day) was orally administered for 14 days before induction of ulcerative colitis.,False,Is the triple 'Ivabradine prevents atrial fibrillation' supported by the sentence: 'Zeaxanthin (50 mg/kg/day) or prednisolone (5 mg/kg/day) was orally administered for 14 days before induction of ulcerative colitis.'?,"No, the statement does not provide indirect support for the claim that Ivabradine prevents atrial fibrillation. The substances mentioned in the statement, Zeaxanthin and prednisolone, have no direct relationship or shared mechanism with Ivabradine that would suggest it has any influence on atrial fibrillation prevention. Additionally, ulcerative colitis induction is unrelated to atrial fibrillation; therefore, any effects observed would not translate to atrial fibrillation prevention by Ivabradine." -10817471,Ivabradine prevents Tachycardia,186,"OBJECTIVE: We want to show that an intralesional injection of prednisolone into the proximal nail fold may produce dorsal pain, dyspnoea and headaches within the 2 min following the injection and to explain the pathophysiology of his condition.",False,"Is the triple 'Ivabradine prevents Tachycardia' supported by the sentence: 'OBJECTIVE: We want to show that an intralesional injection of prednisolone into the proximal nail fold may produce dorsal pain, dyspnoea and headaches within the 2 min following the injection and to explain the pathophysiology of his condition.'?","No, the statement does not provide indirect support for the claim that ""Ivabradine prevents Tachycardia"". The objective in the statement is focused on demonstrating the effects of an intralesional injection of prednisolone on various symptoms such as dorsal pain, dyspnoea (shortness of breath), and headaches within 2 minutes following injection. The statement does not mention Ivabradine at all, let alone its potential in preventing tachycardia (a rapid heart rate). Therefore, there is no connection between these two pieces of information that would allow us to infer support for the claim about Ivabradine." -19153602,Ivabradine predisposes atrial fibrillation,187,[A case of nephrotic syndrome with abnormally high level of protein C induced by prednisolone].,False,Is the triple 'Ivabradine predisposes atrial fibrillation' supported by the sentence: '[A case of nephrotic syndrome with abnormally high level of protein C induced by prednisolone].'?,"No, the statement does not provide any indirect support for the phrase ""Ivabradine predisposes atrial fibrillation."" The statement discusses a case of nephrotic syndrome induced by prednisolone, which is an unrelated glucocorticoid medication used primarily for its anti-inflammatory effects. Ivabradine is a different medication primarily used for heart rate reduction in patients with chronic heart failure or stable angina pectoris. + Nonetheless, it is essential to consider that long-term use of glucocorticoids like prednisolone has been associated with various side effects," +10623724,Prednisolone related to hemolytic anemia,253,Absorption of hydrocortisone from the skin reservoir in atopic dermatitis.,False,"'Does the phrase ""Prednisolone related to hemolytic anemia"" receive at least indirect support from the statement: ""Absorption of hydrocortisone from the skin reservoir in atopic dermatitis.""?","No, the statement ""Absorption of hydrocortisone from the skin reservoir in atopic dermatitis"" does not provide indirect support for the phrase ""Prednisolone related to hemolytic anemia."" - The two medications have different mechanisms of action; prednisolone affects inflammation by modulating gene expression through nuclear factor-kappa B (NF-κB) pathways while ivabradine selectively inhibits the ""funny"" current (I(f)) in the sinoatrial node cells to reduce heart rate without affecting myocardial contractility or conduction velocity. + The two statements discuss different corticosteroids (hydrocortisone vs prednisolone) and different medical conditions (skin absorption in atopic dermatitis vs hemolytic anemia). Hemolytic anemia is a condition characterized by the premature destruction of red blood cells, which can be caused by various factors including certain medications like prednisolone. However, hydrocortisone absorption in atopic dermatitis does not inherently suggest any connection to prednisolone-induced hemolytic anemia. - Furthermore, there is no mention of atrial fibrillation (AFib) in the provided statement. AFib is an abnormal heart rhythm originating in the atria that can lead to palpitations, shortness of breath, and even stroke if left untreated. Although ivabradine is associated with bradycardia" -15385004,Cefixime affects chronic bronchitis,188,It is concluded that six or more cycles of COPP chemotherapy for advanced Hodgkin's disease in men leads to permanent sterility.,False,Is the triple 'Cefixime affects chronic bronchitis' supported by the sentence: 'It is concluded that six or more cycles of COPP chemotherapy for advanced Hodgkin's disease in men leads to permanent sterility.'?,"No, the statement does not provide any indirect support for the phrase ""Cefixime affects chronic bronchitis."" The conclusion drawn in the statement is about the impact of COPP chemotherapy on fertility in men with advanced Hodgkin's disease. Cefixime is an antibiotic used to treat various bacterial infections and has no direct relation to chronic bronchitis or chemotherapy-induced sterility." -15252860,Cefixime affects gonorrhea,189,The erythroderma improved generally as a result of systemic prednisolone treatment.,False,Is the triple 'Cefixime affects gonorrhea' supported by the sentence: 'The erythroderma improved generally as a result of systemic prednisolone treatment.'?,"No, the statement ""The erythroderma improved generally as a result of systemic prednisolone treatment"" does not provide indirect support for the phrase ""Cefixime affects gonorrhea"". + To establish indirect support for the connection between prednisolone and hemolytic anemia, one would need evidence linking prednisolone use to hemolytic anemia, not just any corticosteroid use or hydrocortisone use in particular." +10576837,Prednisolone related to juvenile idiopathic arthritis,254,OBJECTIVE: To assess dexamethasone (DEX) and hydrocortisone (HC) use in premature infants over time and the association of steroid use with the incidence of bronchopulmonary dysplasia (BPD) at 36 weeks' postmenstrual age.,False,"'Does the phrase ""Prednisolone related to juvenile idiopathic arthritis"" receive at least indirect support from the statement: ""OBJECTIVE: To assess dexamethasone (DEX) and hydrocortisone (HC) use in premature infants over time and the association of steroid use with the incidence of bronchopulmonary dysplasia (BPD) at 36 weeks' postmenstrual age.""?","No, the statement does not provide indirect support for the phrase ""Prednisolone related to juvenile idiopathic arthritis."" The statement focuses on assessing dexamethasone (DEX) and hydrocortisone (HC) use in premature infants over time and their association with bronchopulmonary dysplasia (BPD) at 36 weeks postmenstrual age. Prednisolone is not mentioned in the statement; therefore, it does not offer any support for the claimed relationship between Prednisolone and juvenile idiopathic arthritis. - The improvement of erythroderma (a severe form of skin inflammation) due to systemic prednisolone treatment is related to the therapeutic effects of prednisolone, a corticosteroid used in treating various inflammatory conditions. This information does not make any mention of Cefixime, an antibiotic commonly used to treat infections such as gonorrhea. + To further elaborate, Prednisolone is a type of corticosteroid often used in treating various medical conditions, including juvenile idiopathic arthritis (JIA). However, JIA is not mentioned in the statement either; hence no connection can be inferred between Prednisolone use and JIA from this information alone. - Furthermore, there is no explicit or implicit connection between prednisolone treatment for skin inflammation and Cefixime's potential effects on gonorrhea. Therefore, it is not reasonable to infer support for the statement ""Cefixime affects gonorrhea"" based on the provided information about prednisolone treatment for erythroderma." -18811968,Cefixime prevents otitis media,190,CONTACT DERMATITIS DUE TO TOPICAL HYDROCORTISONE AND PREDNISOLONE.,False,Is the triple 'Cefixime prevents otitis media' supported by the sentence: 'CONTACT DERMATITIS DUE TO TOPICAL HYDROCORTISONE AND PREDNISOLONE.'?,"No, the statement ""CONTACT DERMATITIS DUE TO TOPICAL HYDROCORTISONE AND PREDNISOLONE"" does not provide indirect support for the claim that ""Cefixime prevents otitis media."" + It is essential to ensure that any conclusions drawn from scientific statements are based on direct evidence pertaining to the subject under investigation. Inaccurate interpretation of information can lead to misconceptions and incorrect decision-making in" +10565620,Prednisolone related to nephrotic syndrome,255,Increased ratio of mRNA expression of the genes CYP17 and CYP11B1 indicates autonomous cortisol production in adrenocortical tumors.,False,"'Does the phrase ""Prednisolone related to nephrotic syndrome"" receive at least indirect support from the statement: ""Increased ratio of mRNA expression of the genes CYP17 and CYP11B1 indicates autonomous cortisol production in adrenocortical tumors.""?","No, the statement does not provide direct or indirect support for the phrase ""Prednisolone related to nephrotic syndrome."" - The statement is about contact dermatitis caused by topical application of hydrocortisone and prednisolone, which is not related to otitis media (middle ear infection) or Cefixime (an antibiotic used for treating various bacterial infections). Therefore, there is no logical connection between these two statements that would allow for indirect support from one to the other in terms of their respective contents." -17748395,Trimetazidine related to diabetic kidney disease,191,[Pulmonary tuberculosis due to prednisolone].,False,Is the triple 'Trimetazidine related to diabetic kidney disease' supported by the sentence: '[Pulmonary tuberculosis due to prednisolone].'?,"No, the statement ""Pulmonary tuberculosis due to prednisolone"" does not provide indirect support for the phrase ""Trimetazidine related to diabetic kidney disease"". This is because prednisolone is a corticosteroid medication used for various conditions such as inflammation and allergies, while Trimetazidine is primarily used in treating angina pectoris (chest pain) due to coronary artery disease. Diabetic kidney disease is a complication associated with diabetes mellitus, and there is no direct or indirect connection between prednisolone-induced pulmonary tuberculosis and Trimetazidine-related diabetic kidney disease based on the given statement." -22426756,Trimetazidine affects diabetic kidney disease,192,"Rats were treated with a leukotriene synthesis inhibitor (PF-5901), a leukotriene B4 receptor antagonist (SC-41930), an IL-1 receptor antagonist or a corticosteroid (prednisolone) prior to induction of colitis.",False,"Is the triple 'Trimetazidine affects diabetic kidney disease' supported by the sentence: 'Rats were treated with a leukotriene synthesis inhibitor (PF-5901), a leukotriene B4 receptor antagonist (SC-41930), an IL-1 receptor antagonist or a corticosteroid (prednisolone) prior to induction of colitis.'?","No, the statement does not provide any direct or indirect support for the claim that Trimetazidine affects diabetic kidney disease. The provided statement discusses various treatments given to rats before induction of colitis, which is unrelated to diabetic kidney disease or Trimetazidine treatment. To evaluate whether Trimetazidine affects diabetic kidney disease, studies involving Trimetazidine administration in diabetic kidney disease models would be required." -21297588,Trimetazidine affects Cardiotoxicity,193,"PURPOSE: To investigate the relationship between vitamin E deficiency and prednisolone-induced cataract formation, long-term examination of lens changes was performed in rats under the condition of vitamin E deficiency or supplementation and administration of prednisolone.",False,"Is the triple 'Trimetazidine affects Cardiotoxicity' supported by the sentence: 'PURPOSE: To investigate the relationship between vitamin E deficiency and prednisolone-induced cataract formation, long-term examination of lens changes was performed in rats under the condition of vitamin E deficiency or supplementation and administration of prednisolone.'?","No, the statement does not provide indirect support for the claim that Trimetazidine affects Cardiotoxicity. The purpose statement is about an investigation into vitamin E deficiency and prednisolone-induced cataract formation in rats, which is unrelated to Trimetazidine or cardiotoxicity. The two subjects are distinct and there is no overlap in their respective areas of study." -19164679,Trimetazidine affects cardiovascular disorder,194,"In inactive SLE induced by prednisolone therapy, the invariant Valpha24JalphaQ TCR could be detected in DN Valpha24+ T cells from all the patients and dominated in most of the patients.",False,"Is the triple 'Trimetazidine affects cardiovascular disorder' supported by the sentence: 'In inactive SLE induced by prednisolone therapy, the invariant Valpha24JalphaQ TCR could be detected in DN Valpha24+ T cells from all the patients and dominated in most of the patients.'?","No, the statement does not provide any direct or indirect support for the claim that Trimetazidine affects cardiovascular disorder. The statement discusses the presence and dominance of invariant Valpha24JalphaQ TCR in DN Valpha24+ T cells in patients under prednisolone therapy for inactive Systemic Lupus Erythematosus (SLE). This information is not related to Trimetazidine or its effects on cardiovascular disorders." -18547788,Trimetazidine prevents Cardiotoxicity,195,"Interleukin-1 (IL-1) blockers, CK 127 and CK 129, were found to inhibit IL-1-induced posterior uveitis very effectively at 3-10 mg/kg i.p. and were more potent than prednisolone which required at least 20 mg/kg i.p. to achieve the same level of anti-uveitis action.",False,"Is the triple 'Trimetazidine prevents Cardiotoxicity' supported by the sentence: 'Interleukin-1 (IL-1) blockers, CK 127 and CK 129, were found to inhibit IL-1-induced posterior uveitis very effectively at 3-10 mg/kg i.p. and were more potent than prednisolone which required at least 20 mg/kg i.p. to achieve the same level of anti-uveitis action.'?","No, the statement does not provide indirect support for the claim that Trimetazidine prevents cardiotoxicity. The two statements discuss different subjects: one is about interleukin-1 blockers (CK 127 and CK 129) inhibiting IL-1-induced posterior uveitis in an animal model, while the other would be about Trimetazidine preventing cardiotoxicity in humans or animal models. + Prednisolone is a synthetic glucocorticoid often used in treating nephrotic syndrome, but it is not explicitly mentioned in the provided statement. The statement discusses an increased ratio of mRNA expression of the genes CYP17 and CYP11B1 as an indicator of autonomous cortisol production in adrenocortical tumors. While these genes play a role in cortisol production in the adrenal gland, there is no mention of Prednisolone nor its relation to nephrotic syndrome in any capacity within the statement. - Even if we consider that both statements involve therapeutic interventions in diseases (cardiotoxicity in one case and uveitis in another), there is no overlap in terms of mechanisms, drug compounds, or disease models that would justify inferring any relationship between them. + To establish support for such a phrase, one would need evidence linking Prednisolone usage to nephrotic syndrome occurrence or progression, as well as any potential association between autonomous cortisol production in adrenocortical tumors (indicated by CYP17 and CYP11B1 gene expression) and Prednisolone use in nephrotic syndrome patients." +10531966,Prednisolone related to allergic disease,256,"It is concluded that bile acids are potent endogenous inhibitors of 11 beta-HSD and, therefore, could participate in abnormalities of cortisol metabolism observed in liver cirrhosis and extrahepatic biliary obstruction and, possibly, after ingestion of bile acids.",False,"'Does the phrase ""Prednisolone related to allergic disease"" receive at least indirect support from the statement: ""It is concluded that bile acids are potent endogenous inhibitors of 11 beta-HSD and, therefore, could participate in abnormalities of cortisol metabolism observed in liver cirrhosis and extrahepatic biliary obstruction and, possibly, after ingestion of bile acids.""?","No, the statement does not provide direct or indirect support for the phrase ""Prednisolone related to allergic disease."" - In order for the first statement to provide indirect support for the second statement, it would need to involve similar disease mechanisms (e.g., inflammation), share drug compounds (Trimetazidine being an interleukin-1 blocker), or demonstrate similar protective effects in related disease models (e.g., cardiotoxicity models instead of uveitis models). Since none of these connections exist between the two statements, it is not appropriate to infer any relationship between" -13317799,Ranolazine causes atrial fibrillation,196,[A case of hormone-refractory prostate cancer responsive to low-dose prednisolone therapy].,False,Is the triple 'Ranolazine causes atrial fibrillation' supported by the sentence: '[A case of hormone-refractory prostate cancer responsive to low-dose prednisolone therapy].'?,"No, the statement does not provide indirect support for the claim that ""Ranolazine causes atrial fibrillation."" The statement discusses a case of hormone-refractory prostate cancer responsive to low-dose prednisolone therapy, which has no direct relevance or connection to Ranolazine or atrial fibrillation. Therefore, it does not offer any evidence or reasoning that would lead one to infer that Ranolazine causes atrial fibrillation." -19314329,Ranolazine affects cardiovascular disorder,197,6 cases of FSGS had poor response to any therapy; 7 cases were responsive to either triple therapy or cyclosporine A plus prednisolone.,False,Is the triple 'Ranolazine affects cardiovascular disorder' supported by the sentence: '6 cases of FSGS had poor response to any therapy; 7 cases were responsive to either triple therapy or cyclosporine A plus prednisolone.'?,"No, the statement does not provide indirect support for the phrase ""Ranolazine affects cardiovascular disorder"". The statement discusses two groups of patients with FSGS (Focal Segmental Glomerulosclerosis) who had different responses to various therapies including triple therapy and cyclosporine A plus prednisolone. Ranolazine is not mentioned in the statement at all, hence it cannot lend support to any claim about its effects on cardiovascular disorder." -19002641,Ranolazine affects atrial fibrillation,198,"From 1983, exacerbation of PIE was recorded three times, on which occasions prednisolone and antibiotics were quite effective.",False,"Is the triple 'Ranolazine affects atrial fibrillation' supported by the sentence: 'From 1983, exacerbation of PIE was recorded three times, on which occasions prednisolone and antibiotics were quite effective.'?","No, the statement does not provide indirect support for the phrase ""Ranolazine affects atrial fibrillation."" The statement discusses instances where prednisolone and antibiotics were effective in treating exacerbations of PIE (pericardial inflammatory effusion) in 1983. Ranolazine is not mentioned in the statement; therefore, there is no connection that can be inferred between Ranolazine and atrial fibrillation from this information alone. + The statement discusses the role of bile acids as inhibitors of 11 beta-HSD, an enzyme involved in cortisol metabolism. This could potentially explain abnormalities in cortisol metabolism observed in liver cirrhosis, biliary obstruction, and possibly after ingestion of bile acids. - To establish indirect support for the claim about Ranolazine affecting atrial fibrillation using this statement, additional information would be needed that links PIE treatments, such as prednisolone and antibiotics, to Ranolazine usage and atrial fibrillation incidence or severity. Since no such link is provided in the given statement, it cannot offer indirect support for the claim in question." -17881291,Ranolazine affects type 2 diabetes mellitus,199,"A comparative study of the effects of ACTH, hydrocortisone and prednisolone in the hypersensitive reactions produced with the protein components of Hymenolepis nana in albino mice.",False,"Is the triple 'Ranolazine affects type 2 diabetes mellitus' supported by the sentence: 'A comparative study of the effects of ACTH, hydrocortisone and prednisolone in the hypersensitive reactions produced with the protein components of Hymenolepis nana in albino mice.'?","No, the statement does not provide any direct or indirect support for the claim that ""Ranolazine affects type 2 diabetes mellitus."" The study referenced is focused on the effects of ACTH, hydrocortisone, and prednisolone in hypersensitive reactions produced by protein components of Hymenolepis nana in albino mice. There is no mention or implication of Ranolazine or type 2 diabetes mellitus in this study. Therefore, it does not contribute to our understanding or validation of that specific claim." -16599546,Ranolazine affects atrial fibrillation,200,"Immunosuppressant therapy, such as prednisolone or azathioprine, is considered for exacerbations of highly active glomerulonephritis.",False,"Is the triple 'Ranolazine affects atrial fibrillation' supported by the sentence: 'Immunosuppressant therapy, such as prednisolone or azathioprine, is considered for exacerbations of highly active glomerulonephritis.'?","No, the statement does not provide any direct or indirect support for the phrase ""Ranolazine affects atrial fibrillation."" The statement discusses immunosuppressant therapy as an option for managing highly active glomerulonephritis exacerbations, which is unrelated to Ranolazine and its potential effects on atrial fibrillation." -15199166,Ranolazine affects myocardial ischemia,201,"We describe a 57-year-old Caucasian male with anti-MDA5 positive dermatomyositis, that had a 4-month history of progressive dyspnoea requiring oxygen-therapy, scarcely responsive to prednisolone.",False,"Is the triple 'Ranolazine affects myocardial ischemia' supported by the sentence: 'We describe a 57-year-old Caucasian male with anti-MDA5 positive dermatomyositis, that had a 4-month history of progressive dyspnoea requiring oxygen-therapy, scarcely responsive to prednisolone.'?","No, the statement does not provide direct or indirect support for the phrase ""Ranolazine affects myocardial ischemia."" The statement discusses a patient case report about a 57-year-old male suffering from dermatomyositis who experienced progressive dyspnoea despite prednisolone treatment; however, it does not mention Ranolazine or its effects on myocardial ischemia. + Prednisolone is a synthetic glucocorticoid often used in the treatment of allergic diseases due to its anti-inflammatory effects. The statement does not mention Prednisolone or allergic diseases, nor does it establish any connection between bile acids, cortisol metabolism, and Prednisolone use in allergic diseases. Therefore, it does not provide any support for the phrase ""Prednisolone related to allergic disease.""" +10527508,Prednisolone related to acute myeloid leukemia,257,"The plasma cortisol concentration was significantly higher in both DD groups before treatment than in the control group, and it decreased significantly after hoof trimming in the trimmed group.",False,"'Does the phrase ""Prednisolone related to acute myeloid leukemia"" receive at least indirect support from the statement: ""The plasma cortisol concentration was significantly higher in both DD groups before treatment than in the control group, and it decreased significantly after hoof trimming in the trimmed group.""?","No, the statement does not provide indirect support for the phrase ""Prednisolone related to acute myeloid leukemia."" - To better assess whether Ranolazine affects myocardial ischemia, one should look at experimental studies investigating its impact on myocardial ischemia outcomes specifically. This would provide more solid evidence in favor of (or against) that claim." -13887428,Ranolazine disrupts atrial fibrillation,202,"After 14 months of treatment one of the patients developed severe, acute exacerbation of the ABPA and was treated with high-dose prednisolone and local steroid.",False,"Is the triple 'Ranolazine disrupts atrial fibrillation' supported by the sentence: 'After 14 months of treatment one of the patients developed severe, acute exacerbation of the ABPA and was treated with high-dose prednisolone and local steroid.'?","No, the statement does not provide any direct or indirect support for the claim that ""Ranolazine disrupts atrial fibrillation."" The information given pertains to a patient's treatment for acute exacerbation of allergic bronchopulmonary aspergillosis (ABPA) using high-dose prednisolone and local steroid, which has no discernible connection to atrial fibrillation or its disruption by Ranolazine. + The statement discusses changes in plasma cortisol concentration in response to hoof trimming in different groups, but it does not mention Prednisolone or acute myeloid leukemia at all. Prednisolone is a synthetic glucocorticoid often used in medical treatments for various conditions such as inflammation and allergies (Haverkos et al., 2017). Acute myeloid leukemia is a type of cancer affecting blood-forming cells in bone marrow (De Kouchkovsky et al., 2016). - To further clarify, Ranolazine is primarily used in treating chronic angina by inhibiting late sodium current in cardiac myocytes. While there have been some studies suggesting its potential in managing atrial fibrillation through its antiarrhythmic properties, the given statement does not offer any evidence linking Ranolazine specifically to atrial fibrillation disruption. + Although both cortisol (a hormone similar to Prednisolone) and Prednisolone can influence immune responses (Haverkos et al., 2017; De Kouchkovsky et al., 2016), there is no direct or indirect connection established between Prednisolone and acute myeloid leukemia in the statement provided. - It is essential in interpreting scientific evidence and statements that causality is clearly established through well-designed experiments and proper controls. The statement provided here does not meet these criteria for implying any connection between Ranolazine usage and atrial fibrillation disruption." -17475563,Ranolazine prevents Angina pectoris,203,"The effect of pretreatment with topical prostaglandin E2, prednisolone and sulphasalazine in experimental colitis has been examined in the rat colon.",False,"Is the triple 'Ranolazine prevents Angina pectoris' supported by the sentence: 'The effect of pretreatment with topical prostaglandin E2, prednisolone and sulphasalazine in experimental colitis has been examined in the rat colon.'?","No, the statement does not provide any direct or indirect support for the claim that ""Ranolazine prevents Angina pectoris"". The experiment mentioned in the statement was conducted on rat colons using topical prostaglandin E2, prednisolone and sulphasalazine, which are not related to Ranolazine or Angina pectoris in any way. Therefore, it does not contribute to our understanding or validation of the claim about Ranolazine preventing Angina pectoris." -14751648,Ranolazine prevents myocardial ischemia,204,"Here, we report a case of prednisolone-dependent gastric sarcoidosis that improved after additional azathioprine, and also review the literature concerning the treatment, especially for prednisolone-dependent cases.",False,"Is the triple 'Ranolazine prevents myocardial ischemia' supported by the sentence: 'Here, we report a case of prednisolone-dependent gastric sarcoidosis that improved after additional azathioprine, and also review the literature concerning the treatment, especially for prednisolone-dependent cases.'?","No, the statement does not provide any direct or indirect support for the claim that ""Ranolazine prevents myocardial ischemia"". The statement discusses a case of prednisolone-dependent gastric sarcoidosis that improved after additional azathioprine treatment and reviews literature related to treatment, specifically for prednisolone-dependent cases. The drug Ranolazine is not mentioned nor is there any information linking it to myocardial ischemia prevention in this context." -14280230,Ranolazine prevents atrial fibrillation,205,"METHODS: In 126 adults (33 healthy control subjects, 31 patients with mild asthma, 32 patients with severe asthma, and 30 patients with prednisolone-dependent asthma) parameters of inflammation (peripheral blood eosinophils and neutrophils) and markers of hemostasis (endogenous thrombin potential [ETP], thrombin-antithrombin complex, plasmin-alpha2-antiplasmin complex, plasminogen activator inhibitor type 1 [PAI-1], D-dimer, and von Willebrand factor [vWF]) were measured in plasma.",False,"Is the triple 'Ranolazine prevents atrial fibrillation' supported by the sentence: 'METHODS: In 126 adults (33 healthy control subjects, 31 patients with mild asthma, 32 patients with severe asthma, and 30 patients with prednisolone-dependent asthma) parameters of inflammation (peripheral blood eosinophils and neutrophils) and markers of hemostasis (endogenous thrombin potential [ETP], thrombin-antithrombin complex, plasmin-alpha2-antiplasmin complex, plasminogen activator inhibitor type 1 [PAI-1], D-dimer, and von Willebrand factor [vWF]) were measured in plasma.'?","No, the statement does not provide indirect support for the claim that ""Ranolazine prevents atrial fibrillation."" The study mentioned measures various inflammation parameters and markers of hemostasis in different groups of patients including healthy controls, but it does not mention anything about Ranolazine or atrial fibrillation in its methods section. Therefore, there is no basis for inferring any relationship between Ranolazine and atrial fibrillation based on this information alone." -17988674,Ranolazine predisposes atrial fibrillation,206,Previous studies from our laboratory revealed that coadministration of EP significantly increased the plasma concentration of prednisolone while decreased the level of cotreated prednisone in rats.,False,Is the triple 'Ranolazine predisposes atrial fibrillation' supported by the sentence: 'Previous studies from our laboratory revealed that coadministration of EP significantly increased the plasma concentration of prednisolone while decreased the level of cotreated prednisone in rats.'?,"No, the statement does not provide indirect support for the phrase ""Ranolazine predisposes atrial fibrillation."" The statement discusses changes in plasma concentration following coadministration of two substances (EP and prednisolone/prednisone) in rats, but it does not mention nor imply any effects on atrial fibrillation nor does it mention Ranolazine. The two subjects (pharmacokinetic interactions and atrial fibrillation) are unrelated in this context. + References: + + De" +10503828,Prednisolone related to seasonal allergic rhinitis,258,Hydrocortisone in culture protects the blast cells in acute myeloblastic leukemia from the lethal effects of cytosine arabinoside.,False,"'Does the phrase ""Prednisolone related to seasonal allergic rhinitis"" receive at least indirect support from the statement: ""Hydrocortisone in culture protects the blast cells in acute myeloblastic leukemia from the lethal effects of cytosine arabinoside.""?","No, the statement does not provide indirect support for the phrase ""Prednisolone related to seasonal allergic rhinitis."" - To establish a connection between the two statements, there would need to be evidence linking Ranolazine to changes in plasma concentration of substances known to predispose atrial fibrillation or direct evidence showing that Ranolazine itself increases atrial fibrillation risk in individuals. In the absence of such evidence, it is unwarranted to make such an association between the two statements." -26862829,Prednisolone related to multiple sclerosis,207,Metabolic effects of high-dose prednisolone treatment in early rheumatoid arthritis: balance between diabetogenic effects and inflammation reduction.,False,Is the triple 'Prednisolone related to multiple sclerosis' supported by the sentence: 'Metabolic effects of high-dose prednisolone treatment in early rheumatoid arthritis: balance between diabetogenic effects and inflammation reduction.'?,"No, the statement does not provide indirect support for the phrase ""Prednisolone related to multiple sclerosis."" The study referenced in the statement investigates the metabolic effects of high-dose prednisolone treatment in early rheumatoid arthritis patients, focusing on diabetogenic effects and inflammation reduction. Multiple sclerosis is an entirely different disease entity from rheumatoid arthritis, and no information regarding multiple sclerosis is provided in the statement. Therefore, it is inappropriate to infer any connection between prednisolone use and multiple sclerosis based solely on this information." -26365803,Prednisolone related to adrenocortical insufficiency,208,"Effects of prednisolone, salbutamol and theophylline on bronchial hyperreactivity and leucocyte chemokinesis in guinea pigs.",False,"Is the triple 'Prednisolone related to adrenocortical insufficiency' supported by the sentence: 'Effects of prednisolone, salbutamol and theophylline on bronchial hyperreactivity and leucocyte chemokinesis in guinea pigs.'?","No, the statement ""Effects of prednisolone, salbutamol and theophylline on bronchial hyperreactivity and leucocyte chemokinesis in guinea pigs"" does not provide indirect support for the phrase ""Prednisolone related to adrenocortical insufficiency"". + The statement discusses the protective effects of Hydrocortisone on blast cells in acute myeloblastic leukemia when exposed to cytosine arabinoside. This finding is related to leukemia treatment and has no direct or indirect implications for seasonal allergic rhinitis or Prednisolone use. Prednisolone is a synthetic glucocorticoid often used in treating inflammatory conditions like asthma and allergies; however, its specific relationship to seasonal allergic rhinitis is not mentioned in either statement. To establish any connection between Prednisolone and seasonal allergic rhinitis, direct evidence supporting such a relationship would be required." +10496403,Prednisolone related to Inflammation,259,Continuous subcutaneous hydrocortisone infusion in Addison's disease.,False,"'Does the phrase ""Prednisolone related to Inflammation"" receive at least indirect support from the statement: ""Continuous subcutaneous hydrocortisone infusion in Addison's disease.""?","No, the statement ""Continuous subcutaneous hydrocortisone infusion in Addison's disease"" does not provide direct or indirect support for the phrase ""Prednisolone related to Inflammation."" - The statement discusses an experiment conducted on guinea pigs, where prednisolone is used along with salbutamol and theophylline. The focus of the study is on bronchial hyperreactivity and leucocyte chemokinesis, which are immune responses typically associated with asthma or allergies rather than adrenocortical insufficiency. + Here's why: - Adrenocortical insufficiency (also known as Addison's disease) is characterized by impaired production of cortisol from the adrenal glands. Prednisolone is a synthetic glucocorticoid often used as replacement therapy in cases where adrenal insufficiency is present; however, its use in healthy individuals can suppress the natural cortisol production in the adrenal glands. + Hydrocortisone and Prednisolone are both corticosteroids, but they have different specific uses and mechanisms of action. Hydrocortisone is primarily used for its glucocorticoid effect, which includes anti-inflammatory and immunosuppressive actions. It is often used in conditions like Addison's disease, which is a disorder of the adrenal glands that results in decreased production of hormones such as cortisol. - In summary, while prednisolone can" -26295217,Prednisolone related to angioimmunoblastic T-cell lymphoma,209,"This is the first case to support the beneficial effect of prednisolone in pericarditis with pSS, and illustrates its safety during pregnancy.",False,"Is the triple 'Prednisolone related to angioimmunoblastic T-cell lymphoma' supported by the sentence: 'This is the first case to support the beneficial effect of prednisolone in pericarditis with pSS, and illustrates its safety during pregnancy.'?","No, the statement does not provide indirect support for the phrase ""Prednisolone related to angioimmunoblastic T-cell lymphoma."" The statement discusses the beneficial effect and safety of prednisolone in pericarditis with primary Sjogren's syndrome (pSS) during pregnancy, but it does not mention nor imply any connection between prednisolone and angioimmunoblastic T-cell lymphoma. + Prednisolone, on the other hand, is also used for its anti-inflammatory effects but is often used in different clinical contexts. It is more potent than hydrocortisone and has a longer half-life, making it useful for conditions requiring prolonged suppression of inflammation. - Angioimmunoblastic T-cell lymphoma is a rare form of non-Hodgkin lymphoma that can be associated with autoimmune diseases like pSS; however, there is no mention of such an association in this particular statement. Therefore, it is inappropriate to infer any relationship between prednisolone use and angioimmunoblastic T-cell lymphoma based on this information alone." -26194122,Prednisolone related to synovitis,210,"When combined with environmental control, prednisolone and dexamethasone treatments had similar effects on heaves score, blood gases and endoscopic scores.",False,"Is the triple 'Prednisolone related to synovitis' supported by the sentence: 'When combined with environmental control, prednisolone and dexamethasone treatments had similar effects on heaves score, blood gases and endoscopic scores.'?","No, the phrase ""Prednisolone related to synovitis"" does not receive direct or indirect support from the statement provided. The statement discusses the effects of prednisolone and dexamethasone on heaves score, blood gases, and endoscopic scores in an unspecified context (possibly related to heaves in horses). However, synovitis is not mentioned anywhere in the statement. Synovitis is inflammation of the synovial membrane which lines joint capsules and tendon sheaths; it is not directly related to heaves in horses or blood gases. Therefore, there is no basis for connecting prednisolone use in this context to synovitis based on the given statement alone." -25959730,Prednisolone related to sarcoma,211,"Of the 20 patients, 14 initially received prednisolone treatment, which resulted in rapid improvement and normalization of eosinophilia within 8 weeks; however, 2 patients with splenomegaly showed poor control of eosinophilia in response to corticosteroid treatment.",False,"Is the triple 'Prednisolone related to sarcoma' supported by the sentence: 'Of the 20 patients, 14 initially received prednisolone treatment, which resulted in rapid improvement and normalization of eosinophilia within 8 weeks; however, 2 patients with splenomegaly showed poor control of eosinophilia in response to corticosteroid treatment.'?","No, the statement does not provide direct or indirect support for the phrase ""Prednisolone related to sarcoma"". The statement discusses the effects of prednisolone on eosinophilia in patients but does not mention sarcoma at all. Sarcoma is a type of cancer that originates in connective tissue such as bone, cartilage, fat, muscle, blood vessels, or other supportive tissue. The evidence presented in the statement is not relevant to making any conclusions about whether prednisolone has any connection to sarcoma." -25621708,Prednisolone related to uveitis,212,Complement activation capacity in plasma before and during high-dose prednisolone treatment and tapering in exacerbations of Crohn's disease and ulcerative colitis.,True,Is the triple 'Prednisolone related to uveitis' supported by the sentence: 'Complement activation capacity in plasma before and during high-dose prednisolone treatment and tapering in exacerbations of Crohn's disease and ulcerative colitis.'?,"Yes, indirectly it does provide some support for the association between Prednisolone and uveitis. The statement discusses high-dose prednisolone treatment in exacerbations of Crohn's disease and ulcerative colitis. Prednisolone is a corticosteroid often used to treat inflammatory conditions such as these. Uveitis is also an inflammatory condition, specifically affecting the eye. Therefore, there could be a connection between Prednisolone use and uveitis due to their common involvement in inflammatory responses. However, it is important to note that this paper does not directly study or mention uveitis, so it does not provide direct evidence. It simply suggests a potential indirect link through their shared involvement in inflammation." -24523226,Prednisolone related to glomerulonephritis,213,Prednisolone-responsive headache in patients with solitary cysticercus granuloma and seizures.,False,Is the triple 'Prednisolone related to glomerulonephritis' supported by the sentence: 'Prednisolone-responsive headache in patients with solitary cysticercus granuloma and seizures.'?,"No, the statement ""Prednisolone-responsive headache in patients with solitary cysticercus granuloma and seizures"" does not provide indirect support for the claim ""Prednisolone related to glomerulonephritis."" + The statement ""Continuous subcutaneous hydrocortisone infusion in Addison'" +10118116,Prednisolone related to Prednisone,260,The current findings underline the relevance of cortisol and DHEA assessments and the need for further scrutiny of their interplay to foster our understanding of the biological basis of stress regulation in BPD.,False,"'Does the phrase ""Prednisolone related to Prednisone"" receive at least indirect support from the statement: ""The current findings underline the relevance of cortisol and DHEA assessments and the need for further scrutiny of their interplay to foster our understanding of the biological basis of stress regulation in BPD.""?","No, the statement does not provide indirect support for the phrase ""Prednisolone related to Prednisone."" The statement discusses cortisol and DHEA assessments in relation to stress regulation in Borderline Personality Disorder (BPD). Prednisolone and Prednisone are both synthetic glucocorticoids used in medical treatments but they are not mentioned nor implied in the given statement about cortisol and DHEA in BPD patients." +9924521,Prednisolone related to colitis,261,"This hypoxia-specific increase in surface beta-adrenoreceptors was significantly enhanced in the cortisol-treated erythrocytes, showing that cortisol had a significant impact on erythrocyte beta-adrenoreceptor dynamics in addition to the direct influence of hypoxia.",False,"'Does the phrase ""Prednisolone related to colitis"" receive at least indirect support from the statement: ""This hypoxia-specific increase in surface beta-adrenoreceptors was significantly enhanced in the cortisol-treated erythrocytes, showing that cortisol had a significant impact on erythrocyte beta-adrenoreceptor dynamics in addition to the direct influence of hypoxia.""?","No, the statement does not provide indirect support for the phrase ""Prednisolone related to colitis."" - - The statement discusses prednisolone as a treatment for headaches in patients with solitary cysticercus granuloma and seizures. It does not mention glomerulonephritis or any renal-related issues. Glomerulonephritis is a condition characterized by inflammation in the glomeruli (a part of the kidney responsible for filtering waste from blood). Prednisolone is a type of corticosteroid that can be used to suppress inflammation in various conditions; however, it does not necessarily imply that prednisolone is related to glomerulonephritis in any way. + The statement discusses the effect of cortisol on erythrocyte beta-adrenoreceptor dynamics under hypoxic conditions. Prednisolone is a synthetic glucocorticoid often used in clinical settings as an anti-inflammatory agent, similar to cortisol (hydrocortisone). However, there is no mention of colitis or even gut inflammation in the statement provided. - - It is important to base conclusions on evidence that specifically addresses the claim in question; therefore, without any mention of glomerulonephritis in relation to prednisolone in the given statement, it does not lend support for such a claim." -23496152,Prednisolone related to subacute thyroiditis,214,"The patient was treated with chemotherapy by cyclophosphamide, hydroxydoxorubicin, vincristine and prednisolone (CHOP), however, it was ineffective, and the patient died of hemorrhage from the lymphoma involvement of the intestine 5 months after the onset of disease.",False,"Is the triple 'Prednisolone related to subacute thyroiditis' supported by the sentence: 'The patient was treated with chemotherapy by cyclophosphamide, hydroxydoxorubicin, vincristine and prednisolone (CHOP), however, it was ineffective, and the patient died of hemorrhage from the lymphoma involvement of the intestine 5 months after the onset of disease.'?","No, the statement does not provide indirect support for the phrase ""Prednisolone related to subacute thyroiditis."" The information given relates to a patient receiving chemotherapy treatment involving cyclophosphamide, hydroxydoxorubicin, vincristine, and prednisolone (CHOP) for lymphoma, but it does not mention any connection between prednisolone and subacute thyroiditis in this context. + Colitis is inflammation of the inner lining of the colon, which can have various causes such as infections, autoimmune conditions, or side effects of certain medications like nonsteroidal anti-inflammatory drugs (NSAIDs) but not corticosteroids like cortisol or prednisolone. In fact, corticosteroids like prednisolone are often used in treating inflammatory bowel diseases like ulcerative colitis due to their potent anti-inflammatory effects. - The statement highlights that chemotherapy was ineffective in treating the patient's lymphoma, which led to their unfortunate demise due to intestinal hemorrhage caused by lymphoma involvement. Prednisolone is part of the chemotherapy regimen; however, there is no indication regarding its specific effect on subacute thyroiditis in this case. + Therefore, while prednisolone may be related to colitis in some contexts" +9437304,Prednisolone related to systemic lupus erythematosus,262,"Congenital adrenal hyperplasia (CAH) due to deficiency of 21-hydroxylase is a disorder of the adrenal cortex characterised by cortisol deficiency, with or without aldosterone deficiency, and androgen excess.",False,"'Does the phrase ""Prednisolone related to systemic lupus erythematosus"" receive at least indirect support from the statement: ""Congenital adrenal hyperplasia (CAH) due to deficiency of 21-hydroxylase is a disorder of the adrenal cortex characterised by cortisol deficiency, with or without aldosterone deficiency, and androgen excess.""?","No, the statement does not provide indirect support for the phrase ""Prednisolone related to systemic lupus erythematosus"". - Subacute thyroiditis is an inflammatory disorder that can be associated with certain treatments like interferon-alpha and amiodarone; however, prednisolone is not typically related to subacute thyroiditis as demonstrated by available literature and evidence-based guidelines (Bahn et al., 2015). + The statement discusses congenital adrenal hyperplasia (CAH), which is caused by a deficiency of 21-hydroxylase, leading to cortisol deficiency and sometimes aldosterone deficiency, along with androgen excess. Prednisolone is a synthetic glucocorticoid often used in treating various conditions such as CAH due to its ability to mimic cortisol's effects in the body. - In" -22194722,Prednisolone related to pulmonary eosinophilia,215,Effect of prednisolone in the experimentally induced nephropathy in male albino rats.,False,Is the triple 'Prednisolone related to pulmonary eosinophilia' supported by the sentence: 'Effect of prednisolone in the experimentally induced nephropathy in male albino rats.'?,"No, the statement ""Effect of prednisolone in the experimentally induced nephropathy in male albino rats"" does not provide indirect support for the phrase ""Prednisolone related to pulmonary eosinophilia."" The experiment conducted on male albino rats investigates the effect of prednisolone on nephropathy (kidney disease), not pulmonary eosinophilia (a condition involving an increased number of eosinophils in lung tissue). Therefore, there is no connection between prednisolone and pulmonary eosinophilia in this context. + Systemic lupus erythematosus (SLE) is an autoimmune disease in which prednisolone might be used as an immunosuppressive agent to manage inflammation and immune system overactivity. However, there is no connection between CAH, as described in the statement, and SLE that would suggest prednisolone as a treatment for SLE is related to its use in CAH. - + In summary, while prednisolone may be used in treating both CAH and SLE, these conditions are unrelated; thus" +9282196,Prednisolone related to IgA glomerulonephritis,263,"Changes of smoking behavior and serum adrenocorticotropic hormone, cortisol, prolactin, and endogenous opioids levels in nicotine dependence after naltrexone treatment.",False,"'Does the phrase ""Prednisolone related to IgA glomerulonephritis"" receive at least indirect support from the statement: ""Changes of smoking behavior and serum adrenocorticotropic hormone, cortisol, prolactin, and endogenous opioids levels in nicotine dependence after naltrexone treatment.""?","No, the statement does not provide indirect support for the phrase ""Prednisolone related to IgA glomerulonephritis"". The statement discusses changes in smoking behavior and certain hormone levels after naltrexone treatment, which is unrelated to Prednisolone or IgA glomerulonephritis. IgA glomerulonephritis is an autoimmune disease characterized by inflammation of the glomeruli in the kidneys due to IgA immune complex deposition; Prednisolone is a synthetic glucocorticoid used in treating various inflammatory diseases including IgA glomerulonephritis by reducing inflammation in the kidneys. The connection between these two concepts is not evident in the provided statement." +9222009,Prednisolone related to hypereosinophilic syndrome,264,We hypothesize that hydrocortisone infusion in severe community-acquired pneumonia attenuates systemic inflammation and leads to earlier resolution of pneumonia and a reduction in sepsis-related complications.,False,"'Does the phrase ""Prednisolone related to hypereosinophilic syndrome"" receive at least indirect support from the statement: ""We hypothesize that hydrocortisone infusion in severe community-acquired pneumonia attenuates systemic inflammation and leads to earlier resolution of pneumonia and a reduction in sepsis-related complications.""?","No, the statement does not provide indirect support for the phrase ""Prednisolone related to hypereosinophilic syndrome"". - However, it is important to note that prednisolone is a glucocorticoid medication that can have immunosuppressive effects on various parts of the body, including lungs. In some instances, glucocorticoids like prednisolone might be prescribed for treating pulmonary eosinophilia indirectly by modulating immune system activity in the lungs. Nevertheless, based on the provided statement alone, there is no evidence supporting such a relationship between prednisolone and pulmonary eosinophilia" -21911849,Prednisolone related to habitual spontaneous abortion,216,[On the effect of oral use of prednisolone on central chorioretinitis].,False,Is the triple 'Prednisolone related to habitual spontaneous abortion' supported by the sentence: '[On the effect of oral use of prednisolone on central chorioretinitis].'?,"No, the statement ""On the effect of oral use of prednisolone on central chorioretinitis"" does not provide indirect support for the phrase ""Prednisolone related to habitual spontaneous abortion."" The provided statement is about the effect of prednisolone on central chorioretinitis, an eye condition, which is unrelated to spontaneous abortion. Therefore, it does not offer any relevant context or evidence that would lend credence to such a claim about prednisolone being related to habitual spontaneous abortion." -20512112,Prednisolone related to castration-resistant prostate carcinoma,217,Peptic ulceration associated with prednisolone therapy.,False,Is the triple 'Prednisolone related to castration-resistant prostate carcinoma' supported by the sentence: 'Peptic ulceration associated with prednisolone therapy.'?,"No, the statement ""Peptic ulceration associated with prednisolone therapy"" does not provide indirect support for the phrase ""Prednisolone related to castration-resistant prostate carcinoma"". + The statement discusses hydrocortisone infusion in severe community-acquired pneumonia, its potential effects on systemic inflammation, and its impact on the resolution of pneumonia and sepsis-related complications. Hydrocortisone is a type of corticosteroid, similar to prednisolone, but they are not identical. - These two statements discuss different aspects of prednisolone therapy. The first statement discusses an adverse effect (peptic ulceration) associated with prednisolone therapy, while the second statement pertains to a potential association between prednisolone and castration-resistant prostate carcinoma (CRPC). + Furthermore, hypereosinophilic syndrome is a condition characterized by an elevated eosinophil count in the blood (greater than 1500 eosinophils per microliter), which can lead to tissue damage if left untreated. The statement does not mention or imply any connection between corticosteroid use (hydrocortisone) and hypereosinophilic syndrome. Therefore, it does not offer indirect support for the phrase ""Prednisolone related to hypereosinophilic syndrome""." +9216084,Prednisolone related to non-Hodgkin lymphoma,265,A prospective study was performed to investigate the combination of the aromatase inhibitor aminoglutethimide and hydrocortisone in androgen-independent prostate cancer with changes in prostate-specific antigen (PSA) level as main determinant for response.,False,"'Does the phrase ""Prednisolone related to non-Hodgkin lymphoma"" receive at least indirect support from the statement: ""A prospective study was performed to investigate the combination of the aromatase inhibitor aminoglutethimide and hydrocortisone in androgen-independent prostate cancer with changes in prostate-specific antigen (PSA) level as main determinant for response.""?","No, the statement does not provide indirect support for the phrase ""Prednisolone related to non-Hodgkin lymphoma."" The prospective study mentioned in the statement investigates the combination of aromatase inhibitor aminoglutethimide and hydrocortisone in androgen-independent prostate cancer. Prednisolone is not mentioned in the study, nor is there any connection made between hydrocortisone or any other drug in the study and non-Hodgkin lymphoma. Therefore, there is no basis for inferring any relationship between Prednisolone and non-Hodgkin lymphoma based on this statement alone." +9208405,Prednisolone related to Duchenne muscular dystrophy,266,"To investigate the time courses of the effects of the exogenous glucocorticoid agonists dexamethasone (DEX) and hydrocortisone (HYD) and a glucocorticoid antagonist (RU-38486), and to characterize the local and systemic responses in experimental AP.",False,"'Does the phrase ""Prednisolone related to Duchenne muscular dystrophy"" receive at least indirect support from the statement: ""To investigate the time courses of the effects of the exogenous glucocorticoid agonists dexamethasone (DEX) and hydrocortisone (HYD) and a glucocorticoid antagonist (RU-38486), and to characterize the local and systemic responses in experimental AP.""?","No, the statement does not provide indirect support for the phrase ""Prednisolone related to Duchenne muscular dystrophy."" The statement discusses an investigation into the effects of certain glucocorticoid agonists (dexamethasone and hydrocortisone) and an antagonist (RU-38486) in experimental animals (AP). Prednisolone is not mentioned in this statement; therefore, there is no connection established between Prednisolone and Duchenne muscular dystrophy in this context. - Although both statements relate to prednisolone use, they do not offer any implicit connection between prednisolone and CRPC. To establish indirect support for ""Prednisolone related to castration-resistant prostate carcinoma"", there should be some evidence suggesting that prednisolone has an impact on prostate cancer or its progression, which is not provided in the initial statement about peptic ulceration." -20312000,Prednisolone related to chronic primary adrenal insufficiency,218,"Glucocorticoids (e.g. prednisolone) are cornerstones in the treatment of acute exacerbations of ulcerative colitis (UC), and influence of the leucocyte/endothelial interaction appears to be part of their mode of action.",False,"Is the triple 'Prednisolone related to chronic primary adrenal insufficiency' supported by the sentence: 'Glucocorticoids (e.g. prednisolone) are cornerstones in the treatment of acute exacerbations of ulcerative colitis (UC), and influence of the leucocyte/endothelial interaction appears to be part of their mode of action.'?","No, the statement does not provide direct or indirect support for the phrase ""Prednisolone related to chronic primary adrenal insufficiency."" The provided assertion discusses glucocorticoids (including prednisolone) as part of ulcerative colitis (UC) treatment, focusing on their impact on leukocyte-endothelial interaction as a mode of action for acute exacerbations management. It does not mention chronic primary adrenal insufficiency nor suggest any connection between prednisolone and that condition." -20106181,Prednisolone related to allergic bronchopulmonary aspergillosis,219,"Effects of honey, prednisolone, and disulfiram on inflammation, nitric oxide, and free radical formation.",False,"Is the triple 'Prednisolone related to allergic bronchopulmonary aspergillosis' supported by the sentence: 'Effects of honey, prednisolone, and disulfiram on inflammation, nitric oxide, and free radical formation.'?","No, the statement ""Effects of honey, prednisolone, and disulfiram on inflammation, nitric oxide, and free radical formation"" does not provide direct or indirect support for the phrase ""Prednisolone related to allergic bronchopulmonary aspergillosis."" + However, it is important to note that Prednisolone is indeed a type of glucocorticoid used in treating Duchenne muscular dystrophy due to its anti-inflammatory properties that can help manage symptoms of the disease, such as muscle weakness. Nonetheless, based on the information provided in the statement alone, no support can be found for the connection between Prednisolone and Duchenne muscular dystrophy." +8405261,Prednisolone related to asthma,267,[The adrenal cortex and hydrocortisone metabolism in experimental myocardial infarct].,False,"'Does the phrase ""Prednisolone related to asthma"" receive at least indirect support from the statement: ""[The adrenal cortex and hydrocortisone metabolism in experimental myocardial infarct].""?","No, the phrase ""Prednisolone related to asthma"" does not receive direct or indirect support from the statement: ""[The adrenal cortex and hydrocortisone metabolism in experimental myocardial infarct]."" - The statement discusses the general effects of honey, prednisolone, and disulfiram on inflammation, nitric oxide, and free radical formation. However, it does not mention or imply any connection between prednisolone and allergic bronchopulmonary aspergillosis specifically. - - Allergic bronchopulmonary aspergillosis (ABPA) is a condition that affects people who have asthma or cystic fibrosis. It is caused by an allergic reaction to Aspergillus fungus in the lungs. Prednisolone is a corticosteroid that can be used to treat inflammation in the lungs associated with ABPA, but it does not cause ABPA. + Prednisolone is a synthetic glucocorticoid used in various clinical settings for its potent anti-inflammatory effects. It is often used off-label for managing asthma symptoms due to its ability to reduce airway inflammation and hyperresponsiveness [1]. However, there is no mention of Prednisolone or its connection to asthma in the provided statement. - Therefore, while prednisolone may be related to ABPA in terms" -19750187,Prednisolone related to lymphoma,220,OBJECTIVE: To assess the treatment effect of sodium hyaluronate (HA) on experimental temporomandibular joint (TMJ) osteoarthritis of rabbits in comparison with prednisolone (PS).,False,Is the triple 'Prednisolone related to lymphoma' supported by the sentence: 'OBJECTIVE: To assess the treatment effect of sodium hyaluronate (HA) on experimental temporomandibular joint (TMJ) osteoarthritis of rabbits in comparison with prednisolone (PS).'?,"No, the statement does not provide indirect support for the phrase ""Prednisolone related to lymphoma."" The objective is about an experimental study comparing sodium hyaluronate (HA) treatment effect on temporomandibular joint (TMJ) osteoarthritis in rabbits versus prednisolone (PS). The statement does not make any connection between prednisolone and lymphoma; hence it does not support the given phrase. - Prednisolone is a synthetic glucocorticoid used in various clinical settings for its potent anti-inflammatory effects; however, it has been associated with increased risks for certain malignancies such as lymphoma in some studies. Nonetheless, more evidence is required before making any direct connection between prednisolone use and lymphoma development. In order for there to be indirect support for such a claim using the provided statement as evidence, there would need to be some mention linking prednisolone use in rabbits (or animals in general) to lymphoma; however, such information is absent from the statement provided." -17143213,Prednisolone related to temporal arteritis,221,"ETO+PSL combination treatment, however, failed to show significant enhancement of anti-tumor effects.",False,"Is the triple 'Prednisolone related to temporal arteritis' supported by the sentence: 'ETO+PSL combination treatment, however, failed to show significant enhancement of anti-tumor effects.'?","No, the statement ""ETO+PSL combination treatment, however, failed to show significant enhancement of anti-tumor effects"" does not provide indirect support for the phrase ""Prednisolone related to temporal arteritis."" + The statement focuses on the adrenal cortex and hydrocortisone metabolism in an experimental setting related to myocardial infarction (heart attack). The adrenal cortex is responsible for releasing corticosteroids like cortisol (hydrocortisone) in response to stress [2]. While Prednisolone is a synthetic glucocorticoid similar to cortisol in structure and function, there is no explicit or implicit connection between Prednisol" +7844202,Prednisolone related to chronic obstructive pulmonary disease,268,[Intraarticular hydrocortisone (cortril) in arthritis and osteoarthritis].,False,"'Does the phrase ""Prednisolone related to chronic obstructive pulmonary disease"" receive at least indirect support from the statement: ""[Intraarticular hydrocortisone (cortril) in arthritis and osteoarthritis].""?","No, the statement does not provide indirect support for the phrase ""Prednisolone related to chronic obstructive pulmonary disease."" The statement discusses intraarticular hydrocortisone (cortril) used in arthritis and osteoarthritis but does not mention prednisolone nor chronic obstructive pulmonary disease (COPD). Prednisolone is a synthetic glucocorticoid commonly used in various inflammatory conditions (e.g., asthma, allergies) while COPD is a chronic lung disease characterized by persistent respiratory symptoms (e.g., breathlessness, cough). The lack of connection between hydrocortisone in arthritis/osteoarthritis does not imply any relationship between prednisolone and COPD." +7323744,Prednisolone related to pemphigus,269,[Use of cortisone and hydrocortisone in eye diseases].,False,"'Does the phrase ""Prednisolone related to pemphigus"" receive at least indirect support from the statement: ""[Use of cortisone and hydrocortisone in eye diseases].""?","No, the statement does not provide indirect support for the phrase ""Prednisolone related to pemphigus."" The statement mentions cortisone and hydrocortisone, which are related to prednisolone as they all belong to the class of corticosteroids, but it does not specifically mention prednisolone or its use in pemphigus, a group of autoimmune blistering disorders. Therefore, there is no clear connection that can be inferred from the given statement." +7262473,Prednisolone related to rheumatoid arthritis,270,[Topical use of hydrocortisone in otitis externa].,False,"'Does the phrase ""Prednisolone related to rheumatoid arthritis"" receive at least indirect support from the statement: ""[Topical use of hydrocortisone in otitis externa].""?","No, the statement does not provide indirect support for the phrase ""Prednisolone related to rheumatoid arthritis."" The statement refers specifically to the topical use of hydrocortisone in otitis externa, which is an inflammation of the ear canal. Prednisolone is a different glucocorticoid medication often used systemically (orally or injected) for various conditions including rheumatoid arthritis, but it is not mentioned in the provided statement. Therefore, there is no connection made between Prednisolone and rheumatoid arthritis in this context." +7206314,Prednisolone related to pulmonary tuberculosis,271,The use of hydrocortisone in ulcerative colitis: preliminary observations.,False,"'Does the phrase ""Prednisolone related to pulmonary tuberculosis"" receive at least indirect support from the statement: ""The use of hydrocortisone in ulcerative colitis: preliminary observations.""?","No, the statement ""The use of hydrocortisone in ulcerative colitis: preliminary observations"" does not provide indirect support for the phrase ""Prednisolone related to pulmonary tuberculosis."" - Prednisolone (PSL) is a type of corticosteroid drug often used in treating various conditions such as temporal arteritis due to its potent anti-inflammatory properties. ETO likely refers to Etoposide, another drug used in cancer treatment. The statement provided discusses an experimental combination therapy (ETO+PSL) for enhancing anti-tumor effects in cancer treatment without significant success. + The statement discusses the use of hydrocortisone in ulcerative colitis, which is a type of inflammatory bowel disease. Hydrocortisone is a type of corticosteroid, similar to prednisolone, but they are not identical drugs and have different pharmacological properties. - The connection between prednisolone and temporal arteritis is not addressed or implied in this statement because it focuses on anti-tumor effects rather than inflammatory responses in blood vessels (the primary issue in temporal arteritis). Therefore, it does not offer any support for linking prednisolone to temporal arteritis based on this information alone." -16983852,Prednisolone related to Hodgkins lymphoma,222,"My- and My+ ALL did not significantly differ in sensitivity to prednisolone, dexamethasone, L-asparaginase and cytarabine.",False,"Is the triple 'Prednisolone related to Hodgkins lymphoma' supported by the sentence: 'My- and My+ ALL did not significantly differ in sensitivity to prednisolone, dexamethasone, L-asparaginase and cytarabine.'?","No, the statement does not provide indirect support for the phrase ""Prednisolone related to Hodgkins lymphoma."" The statement discusses the sensitivity of My- and My+ acute lymphoblastic leukemia (ALL) to several drugs including prednisolone, but it does not mention Hodgkin lymphoma at all. Therefore, there is no connection that can be inferred between prednisolone and Hodgkin lymphoma from this statement. + Moreover, the statement does not mention pulmonary tuberculosis at all. Therefore, even if prednisolone was mentioned instead of hydrocortisone, there would still be no connection made to pulmonary tuberculosis in the statement. - It is important to note that Hodgkin lymphoma is a distinct type of cancer from acute lymphoblastic leukemia (ALL), which is mentioned in the statement. Therefore, even if the statement had mentioned an association between prednisolone and ALL, it would not necessarily imply an association between prednisolone and Hodgkin lymphoma. + In order for there to be indirect support for ""Prednisolone related to pulmonary tuberculosis,"" there would need to be some mention of prednisolone use in relation to pulmonary tuberculosis, even if it was not the primary focus of the study. However, in this statement, there is no such mention." +8856354,Prednisolone related to Prednisone,272,It can therefore be concluded that ointments containing either only E. coli BCS or a combination of BCS and hydrocortisone provide significant relief in perianal eczema as well as in early stages of hemorrhoidal disease.,False,"'Does the phrase ""Prednisolone related to Prednisone"" receive at least indirect support from the statement: ""It can therefore be concluded that ointments containing either only E. coli BCS or a combination of BCS and hydrocortisone provide significant relief in perianal eczema as well as in early stages of hemorrhoidal disease.""?","No, the phrase ""Prednisolone related to Prednisone"" does not receive indirect support from the statement provided. The statement discusses the effectiveness of ointments containing Escherichia coli BCS (BCS) alone or in combination with hydrocortisone in treating perianal eczema and early stages of hemorrhoidal disease, but it does not mention Prednisolone or Prednisone at all. - In order for there to be indirect support for the phrase ""Prednisolone related to Hodgkins lymphoma,"" there would need to be some mention or implication in the statement that prednisolone has an effect on Hodgkin lymphoma specifically" -16960031,Prednisolone related to psoriatic arthritis,223,"The dose of prednisolone was increased considering he was exacerbated of SLE, however, the convulsion as CNS lupus occurred to him.",False,"Is the triple 'Prednisolone related to psoriatic arthritis' supported by the sentence: 'The dose of prednisolone was increased considering he was exacerbated of SLE, however, the convulsion as CNS lupus occurred to him.'?","No, the statement does not provide indirect support for the phrase ""Prednisolone related to psoriatic arthritis"". The statement discusses the increase in prednisolone dosage due to an exacerbation of Systemic Lupus Erythematosus (SLE) in a patient who subsequently experienced convulsions due to Central Nervous System lupus (CNS lupus). Psoriatic arthritis is a different condition from SLE and is not mentioned in the statement. Therefore, there is no connection established between prednisolone and psoriatic arthritis in this context." -16502712,Prednisolone related to aplastic anemia,224,"In a pilot study using one rabbit, prednisone and prednisolone clearance values increased with increase in either prednisone or prednisolone infusion rates.",False,"Is the triple 'Prednisolone related to aplastic anemia' supported by the sentence: 'In a pilot study using one rabbit, prednisone and prednisolone clearance values increased with increase in either prednisone or prednisolone infusion rates.'?","No, the statement does not provide direct or indirect support for the phrase ""Prednisolone related to aplastic anemia"". The pilot study mentioned only discusses how prednisone and prednisolone clearance values change with increased infusion rates in one rabbit. There is no mention of aplastic anemia in the statement; therefore it does not offer any evidence linking prednisolone to aplastic anemia. + Prednisolone and Prednisone are synthetic glucocorticoids that share structural similarities but have different pharmacokinetic properties; they can be used interchangeably in some clinical situations due to their similar mechanisms of action. However, there is no mention of these medications in the given statement, so it cannot provide indirect support for any relationship between them. - To provide indirect support for such a claim, there would need to be some connection between prednisolone use and decreased clearance values, which could then be associated with an increased risk for developing aplastic anemia due to higher drug exposure over time. However, none of these connections can be inferred from the provided statement. + To further clarify, Prednisolone is more soluble in water than Prednisone; thus, Prednisolone is often preferred in situations where rapid absorption is desired (e.g., intravenous administration). Prednisone, on the other hand, is more lipid-soluble than Prednisolone; therefore, it is more suitable for oral administration because" +26879702,Prednisolone has part acute lymphoblastic leukemia,273,The effect on cortisol supports the above conclusion and is consistent with HPA axis perturbation in opioid dependence as reported in other studies and extends these observations to stable methadone-maintained patients.,False,"'Does the phrase ""Prednisolone has part acute lymphoblastic leukemia"" receive at least indirect support from the statement: ""The effect on cortisol supports the above conclusion and is consistent with HPA axis perturbation in opioid dependence as reported in other studies and extends these observations to stable methadone-maintained patients.""?","No, the statement does not provide indirect support for the phrase ""Prednisolone has part acute lymphoblastic leukemia."" - Aplastic anemia is an uncommon but serious condition where the body stops producing enough new blood cells. Prednisolone is a corticosteroid that can suppress inflammation and immune response; however, its long-term use has been linked to various side effects such as osteoporosis, weight gain, diabetes, cataracts, glaucoma, increased risk of infections, and ad" -16371065,Prednisolone related to celiac disease,225,"Budesonide is equal to less effective than prednisolone or prednisone therapy in the treatment of active Crohn's disease, but is associated with fewer glucocorticoids adverse reactions.",False,"Is the triple 'Prednisolone related to celiac disease' supported by the sentence: 'Budesonide is equal to less effective than prednisolone or prednisone therapy in the treatment of active Crohn's disease, but is associated with fewer glucocorticoids adverse reactions.'?","No, the statement does not provide direct or indirect support for the phrase ""Prednisolone related to celiac disease."" The statement discusses the efficacy and side effects of Budesonide, Prednisolone, and Prednisone in treating Crohn's disease, but it does not mention or imply any connection between Prednisolone and celiac disease. Celiac disease is an autoimmune disorder triggered by gluten in genetically predisposed individuals, while Prednisolone is a corticosteroid medication used for various inflammatory conditions. Therefore, without further evidence linking Prednisolone specifically to celiac disease, it is not reasonable to make such a connection based on the given statement alone." -16192798,Prednisolone related to dermatomyositis,226,Diclofenac and prednisolone inhibit endotoxin-induced uveitis in rabbits.,False,Is the triple 'Prednisolone related to dermatomyositis' supported by the sentence: 'Diclofenac and prednisolone inhibit endotoxin-induced uveitis in rabbits.'?,"No, the statement ""Diclofenac and prednisolone inhibit endotoxin-induced uveitis in rabbits"" does not provide indirect support for the phrase ""Prednisolone related to dermatomyositis"". + The statement discusses the effects of cortisol and its relation to opioid dependence, specifically in methadone-maintained patients. It does not mention Prednisolone nor acute lymphoblastic leukemia at all. Therefore, it does not offer any form of support for the stated phrase. - The statement discusses the effects of diclofenac and prednisolone on endotoxin-induced uveitis in rabbits. While it does indicate that prednisolone has an effect in this specific context, it does not provide any information about its relationship to dermatomyositis. Dermatomyositis is a specific medical condition characterized by inflammation and damage to muscle tissue and the skin. The statement does not provide any evidence or imply any connection between prednisolone and this condition. Therefore, it cannot be used as indirect support for the phrase in question." -16169223,Prednisolone related to mucocutaneous lymph node syndrome,227,"Although prednisolone and GH reverse hypoglycemia by different mechanisms, with only prednisolone suppressing tumor IGF-II secretion, both increase the formation of ternary IGF-IGFBP-3 complexes.",False,"Is the triple 'Prednisolone related to mucocutaneous lymph node syndrome' supported by the sentence: 'Although prednisolone and GH reverse hypoglycemia by different mechanisms, with only prednisolone suppressing tumor IGF-II secretion, both increase the formation of ternary IGF-IGFBP-3 complexes.'?","No, the statement does not provide indirect support for the phrase ""Prednisolone related to mucocutaneous lymph node syndrome"". The statement discusses the effects of prednisolone on hypoglycemia and IGF-IGFBP-3 complexes but does not mention or imply any connection to mucocutaneous lymph node syndrome. Mucocutaneous lymph node syndrome is an immune system disorder characterized by fever, swollen lymph nodes, skin rashes, and other symptoms, which has not been linked to prednisolone in the provided statement. Therefore, it is inappropriate to make such a connection based on this information alone." -16114172,Prednisolone related to plasma cell myeloma,228,"The aqueous extract of Saiboku-to also showed an inhibition of the contact dermatitis, and it significantly potentiated the inhibition of contact dermatitis by prednisolone.",False,"Is the triple 'Prednisolone related to plasma cell myeloma' supported by the sentence: 'The aqueous extract of Saiboku-to also showed an inhibition of the contact dermatitis, and it significantly potentiated the inhibition of contact dermatitis by prednisolone.'?","No, the statement does not provide direct or indirect support for the phrase ""Prednisolone related to plasma cell myeloma."" The statement discusses an inhibitory effect of prednisolone on contact dermatitis when combined with an aqueous extract of Saiboku-to. There is no mention or implication of any connection between prednisolone and plasma cell myeloma in this statement. + Prednisolone is a synthetic glucocorticoid used primarily for its anti-inflammatory and immunosuppressive effects. Acute lymphoblastic leukemia (ALL) is a type of cancer of the blood and bone marrow that affects white blood cells. While both Prednisolone and leukemia can involve the immune system and hematopoietic cells, there is no direct connection between them based on the provided statement. - To further clarify, let me explain how I arrived at my decision: + It is essential to critically evaluate each claim based on the evidence specifically presented for that claim, rather than drawing connections that may not exist based on unrelated information." +26670577,Prednisolone has part plasma cell myeloma,274,Several randomized controlled trials have evaluated the efficacy of a replacement therapy with hydrocortisone in severe sepsis.,False,"'Does the phrase ""Prednisolone has part plasma cell myeloma"" receive at least indirect support from the statement: ""Several randomized controlled trials have evaluated the efficacy of a replacement therapy with hydrocortisone in severe sepsis.""?","No, the statement does not provide indirect support for the phrase ""Prednisolone has part plasma cell myeloma."" - 1) The statement focuses on the inhibitory effect of prednisolone on contact dermatitis when combined with an herbal extract called Saiboku-to. + The statement discusses randomized controlled trials that have evaluated the efficacy of hydrocortisone replacement therapy in severe sepsis. This information is not related to Prednisolone or its potential involvement in plasma cell myeloma. Prednisolone is a synthetic glucocorticoid used in various medical conditions for its anti-inflammatory and immunosuppressive effects while plasma cell myeloma is a type of cancer that originates from malignant plasma cells in bone marrow. Therefore, there is no connection between Prednisolone and plasma cell myeloma in this context." +18935086,Prednisolone coexists with Prednisone,275,[Diurnal variations in blood glucose and plasma cortisol in juvenile diabetes mellitus without ketoacidosis].,False,"'Does the phrase ""Prednisolone coexists with Prednisone"" receive at least indirect support from the statement: ""[Diurnal variations in blood glucose and plasma cortisol in juvenile diabetes mellitus without ketoacidosis].""?","No, the statement does not provide indirect support for the phrase ""Prednisolone coexists with Prednisone."" The title you provided refers to a study on diurnal variations in blood glucose and plasma cortisol in juvenile diabetes mellitus without ketoacidosis. Prednisolone and Prednisone are both glucocorticoids used in treating various conditions, including diabetes, but the title does not mention nor imply their coexistence in any way. - 2) Plasma cell myeloma is a type of cancer affecting plasma cells in bone marrow, which is unrelated to contact dermatitis or skin inflammation addressed in the statement. + The title focuses on diurnal variations in blood glucose and cortisol levels in juvenile diabetes mellitus without ketoacidosis. While both Prednisolone and Prednisone could impact these levels given their glucocorticoid properties, their coexistence is not suggested by the title alone or supported by any implicit relationship between them in the context of diabetes management. - 3) The provided statement does not mention any studies, experiments, or evidence linking prednisolone to plasma cell myeloma; therefore, it does not provide indirect support either. + In conclusion, there is no indirect support for ""Prednisolone coexists with Prednisone"" in relation to the given statement as it does not mention nor imply their coexistence in any way." +9296680,Prednisolone derives from Prednisone,276,"OBJECTIVES: Elderly women with proximal femur fracture show abnormal persistence of increased cortisol concentrations, which could contribute to the high morbidity associated with this injury.",False,"'Does the phrase ""Prednisolone derives from Prednisone"" receive at least indirect support from the statement: ""OBJECTIVES: Elderly women with proximal femur fracture show abnormal persistence of increased cortisol concentrations, which could contribute to the high morbidity associated with this injury.""?","No, the statement does not provide direct or indirect support for the phrase ""Prednisolone derives from Prednisone."" - 4) Prednisolone is a synthetic glucocorticoid often used in treating various inflammatory diseases due" -14564343,Prednisolone related to acute lymphoblastic leukemia,229,Only hydrocortisone and prednisolone suppressed LPS pneumonia.,False,Is the triple 'Prednisolone related to acute lymphoblastic leukemia' supported by the sentence: 'Only hydrocortisone and prednisolone suppressed LPS pneumonia.'?,"No, the statement does not provide indirect support for the phrase ""Prednisolone related to acute lymphoblastic leukemia."" The statement ""Only hydrocortisone and prednisolone suppressed LPS pneumonia"" addresses the immunosuppressive effects of these corticosteroids in treating LPS pneumonia but does not imply any connection between prednisolone and acute lymphoblastic leukemia (ALL). Acute lymphoblastic leukemia is a type of cancer affecting blood cells, while prednisolone is an immunosuppressive drug used in various clinical settings unrelated to ALL. Therefore, further evidence would be required to establish any link between prednisolone and ALL." -13988965,Prednisolone related to osteoarthritis,230,"Prednisolone significantly inhibited the measurable sensitivity of IDT, while oclacitinib did not.",False,"Is the triple 'Prednisolone related to osteoarthritis' supported by the sentence: 'Prednisolone significantly inhibited the measurable sensitivity of IDT, while oclacitinib did not.'?","No, the statement does not provide direct or indirect support for the phrase ""Prednisolone related to osteoarthritis"". The given statement compares the effects of Prednisolone and oclacitinib on IDT sensitivity but does not mention osteoarthritis. Therefore, we cannot infer any relationship between Prednisolone and osteoarthritis from this information alone." -13151963,Prednisolone related to diffuse large B-cell lymphoma,231,"A comparison with the bronchodilator potency of the above drugs indicated that in guinea pigs salbutamol appears relatively selective as a bronchodilator, prednisolone is selective as an inhibitor of eosinophilia whilst theophylline displays a balance of both activities.",False,"Is the triple 'Prednisolone related to diffuse large B-cell lymphoma' supported by the sentence: 'A comparison with the bronchodilator potency of the above drugs indicated that in guinea pigs salbutamol appears relatively selective as a bronchodilator, prednisolone is selective as an inhibitor of eosinophilia whilst theophylline displays a balance of both activities.'?","No, the statement does not provide indirect support for the phrase ""Prednisolone related to diffuse large B-cell lymphoma."" The statement discusses the effects of prednisolone as an inhibitor of eosinophilia in guinea pigs when compared to other drugs like salbutamol and theophylline. There is no mention or implication of any relationship between prednisolone and diffuse large B-cell lymphoma in humans in this statement." -13151962,Prednisolone related to follicular lymphoma,232,Reduction of maintenance doses of prednisolone in bronchial asthma by the concurrent use of hydroxyzine.,False,Is the triple 'Prednisolone related to follicular lymphoma' supported by the sentence: 'Reduction of maintenance doses of prednisolone in bronchial asthma by the concurrent use of hydroxyzine.'?,"No, the statement does not provide indirect support for the phrase ""Prednisolone related to follicular lymphoma."" The statement discusses reducing maintenance doses of prednisolone in bronchial asthma through concurrent use of hydroxyzine but does not mention or imply any connection between prednisolone and follicular lymphoma. The two subjects—asthma and follicular lymphoma—are distinct conditions that require separate considerations in medical literature. To establish support for the phrase ""Prednisolone related to follicular lymphoma,"" evidence should explicitly demonstrate some form of correlation or causation between prednisolone usage and follicular lymphoma incidence or progression." -12983495,Prednisolone related to prostate cancer,233,"In contrast, cyclosporin A (CyA), FK-506 and prednisolone significantly inhibited antigen-induced airway inflammation and BHR in sensitized BN rats.",False,"Is the triple 'Prednisolone related to prostate cancer' supported by the sentence: 'In contrast, cyclosporin A (CyA), FK-506 and prednisolone significantly inhibited antigen-induced airway inflammation and BHR in sensitized BN rats.'?","No, the statement does not provide indirect support for the phrase ""Prednisolone related to prostate cancer"". The provided quote discusses how prednisolone inhibits antigen-induced airway inflammation and bronchial hyperresponsiveness (BHR) in sensitized Brown Norway (BN) rats, which is related to allergic reactions in the respiratory system rather than prostate cancer. + The statement discusses increased cortisol concentrations in elderly women with proximal femur fractures and their potential contribution to morbidity. Neither Prednisolone nor Prednisone is mentioned in this context. - To establish an indirect link between prednisolone and prostate cancer based on this information, there would need to be some connection between antigen-induced airway inflammation/BHR and prostate cancer; however, no such link has been suggested in the statement provided. Therefore, it is inappropriate to infer any relationship between prednisolone and prostate cancer based solely on this information." -12510603,Prednisolone related to membranous glomerulonephritis,234,[Use of corticosteroids betamethasone and prednisolone in the prevention of allergic reactions in patients undergoing heart surgery with artificial blood circulation].,False,Is the triple 'Prednisolone related to membranous glomerulonephritis' supported by the sentence: '[Use of corticosteroids betamethasone and prednisolone in the prevention of allergic reactions in patients undergoing heart surgery with artificial blood circulation].'?,"No, the statement does not provide direct or indirect support for the phrase ""Prednisolone related to membranous glomerulonephritis."" The statement discusses the use of corticosteroids betamethasone and prednisolone in preventing allergic reactions during heart surgery, which is unrelated to membranous glomerulonephritis. Membranous glomerulonephritis is a kidney disorder characterized by inflammation in the glomeruli (tiny filters in the kidneys), which can be caused by various factors such as infections, autoimmune diseases, or medications, but it is not explicitly associated with prednisolone in this context." -12496746,Prednisolone related to neoplasm,235,The intra-articular injection of prednisolone was shown to considerably reduce incidence of synovitis.,False,Is the triple 'Prednisolone related to neoplasm' supported by the sentence: 'The intra-articular injection of prednisolone was shown to considerably reduce incidence of synovitis.'?,"No, the statement ""The intra-articular injection of prednisolone was shown to considerably reduce incidence of synovitis"" does not provide indirect support for the phrase ""Prednisolone related to neoplasm."" Synovitis is an inflammation of the synovial membrane that lines joints, while neoplasm refers to abnormal growths that can be benign or malignant (cancerous). Although prednisolone has anti-inflammatory properties that can help manage synovitis, there is no direct link established between prednisolone use and neoplasm development in this statement. However, it is important to note that corticosteroids like prednisolone have been associated with certain increased risks for specific types of cancers in some studies; thus, further investigation would be required for a definitive conclusion on any relationship between prednisolone use and neoplasm risk." -12428137,Prednisolone related to croup,236,"Prednisolone (100 mg/die initially, decreasing doses thereafter) led to significant reduction of infiltrates and eosinophilia.",True,"Is the triple 'Prednisolone related to croup' supported by the sentence: 'Prednisolone (100 mg/die initially, decreasing doses thereafter) led to significant reduction of infiltrates and eosinophilia.'?","Yes, there is indirect support for the statement ""Prednisolone related to croup"" from the given evidence. The statement indicates that prednisolone treatment led to a significant reduction in infiltrates and eosinophilia. Croup is a viral infection that often leads to inflammation in the upper airways, which can result in infiltrates and eosinophilia (accumulation of eosinophils in tissues). By demonstrating that prednisolone reduces infiltrates and eosinophilia, it suggests that prednisolone can help alleviate symptoms associated with croup by minimizing inflammation in the upper airways. However, it is important to note that direct evidence specifically linking prednisolone and croup would provide stronger support for the claim." -12061894,Prednisolone related to West syndrome,237,The tumour was significantly reduced by prednisolone.,False,Is the triple 'Prednisolone related to West syndrome' supported by the sentence: 'The tumour was significantly reduced by prednisolone.'?,"No, the statement ""The tumour was significantly reduced by prednisolone"" does not provide direct or indirect support for the phrase ""Prednisolone related to West syndrome"". + Prednisolone is a synthetic glucocorticoid, which is structurally similar to cortisol (a steroid hormone). Prednisone is also a synthetic glucocorticoid but is metabolized in the liver into Prednisolone after absorption in order for it to be active in the body. Therefore, Prednisolone can be considered a metabolite of Prednisone. However, there is no mention of either drug in relation to cortisol in the provided statement. - West syndrome is a specific neurological disorder characterized by infantile spasms, developmental regression, and hypsarrhythmia on EEG. It is often associated with underlying brain abnormalities such as tuberous sclerosis complex, cortical dysplasia, or hypoxic-ischemic encephalopathy. The statement only indicates that prednisolone has an effect on reducing tumour size, which does not necessarily imply any connection with West syndrome. + To establish support for ""Prednisolone derives from Prednisone,"" there would need to be specific evidence linking these two compounds in terms of their synthesis, metabolism, or therapeutic use in medical treatment." +26415442,Prednisolone derives from Prednisone,277,"From the compendium presented above, the following statements become evident: 1) Inappropriately low secretion of cortisol in relation to inflammation is a typical feature of the inflammatory disease in patients with RA.",False,"'Does the phrase ""Prednisolone derives from Prednisone"" receive at least indirect support from the statement: ""From the compendium presented above, the following statements become evident: 1) Inappropriately low secretion of cortisol in relation to inflammation is a typical feature of the inflammatory disease in patients with RA.""?","No, the statement does not provide indirect support for ""Prednisolone derives from Prednisone."" The statement refers to a characteristic of rheumatoid arthritis (RA) patients but does not establish any relationship between Prednisolone and Prednisone. - To establish a relationship between prednisolone and West syndrome, further evidence would be required demonstrating that prednisolone has an effect on the symptoms or underlying pathophysiology specific to West syndrome. This could include studies showing that prednisolone reduces infantile spasms or improves developmental outcomes in patients with West syndrome. + Prednisolone is a synthetic glucocorticoid used for its anti-inflammatory effects and is metabolically equivalent to Prednisone but has better tissue distribution because it does not require hepatic activation like Prednisone does. They share structural similarities but are different drugs. Prednisolone is not derived from Prednisone; instead, Prednisone is converted into Prednisolone in the body through metabolic processes. - Therefore, while prednisolone may have therapeutic value in certain contexts, such as reducing tumour size in brain cancers, it" -11663099,Prednisolone related to Crohn disease,238,"Prednisolone prevented the development of colitis, but had no effect on already-developed colitis.",True,"Is the triple 'Prednisolone related to Crohn disease' supported by the sentence: 'Prednisolone prevented the development of colitis, but had no effect on already-developed colitis.'?","Yes, indirectly it does support that prednisolone is related to Crohn disease. The statement suggests that prednisolone has an effect on colitis prevention, which is a symptom often associated with Crohn disease, a type of inflammatory bowel disease (IBD). Therefore, it implies that prednisolone has some connection or relation to Crohn disease by influencing its symptoms. However, it is essential to note that correlation does not imply causation; more research would be needed to confirm this relationship conclusively." -11638013,Prednisolone related to eosinophilic granulomatosis with polyangiitis,239,Alveolar NO concentration was increased in patients with refractory asthma (7.1 ppb) compared with mild-to-moderate asthma (3.4 ppb) and normal controls (3.4 ppb) and reduced by treatment with prednisolone.,True,Is the triple 'Prednisolone related to eosinophilic granulomatosis with polyangiitis' supported by the sentence: 'Alveolar NO concentration was increased in patients with refractory asthma (7.1 ppb) compared with mild-to-moderate asthma (3.4 ppb) and normal controls (3.4 ppb) and reduced by treatment with prednisolone.'?,"Yes, indirectly it does support that statement. The given statement mentions that alveolar NO concentration is increased in patients with refractory asthma compared to mild-to-moderate asthma and normal controls, and that treatment with prednisolone reduces it. This implies that prednisolone may have an effect on eosinophilic granulomatosis with polyangiitis (EGPA) since EGPA is often associated with asthma symptoms. However, it does not provide direct evidence for prednisolone being related specifically to EGPA but rather suggests its potential effect on inflammation in general which is often observed in EGPA as well as other conditions including asthma. + Therefore, even though both drugs have therapeutic applications in treating inflammatory diseases like RA, one does not derive from another in terms of chemical synthesis or formulation." +14808035,Prednisolone physically interacts with Prednisone,278,Hydrocortisone infusion in septic shock differentially regulated the cytokine responses.,False,"'Does the phrase ""Prednisolone physically interacts with Prednisone"" receive at least indirect support from the statement: ""Hydrocortisone infusion in septic shock differentially regulated the cytokine responses.""?","No, the statement does not provide any direct or indirect support for the phrase ""Prednisolone physically interacts with Prednisone."" - The connection between prednisolone and EGPA can be further supported by existing medical literature where prednisolone is commonly used as part of standard therapy for EGPA due to its anti-inflammatory properties. Nonetheless, more specific studies would need to be conducted to definitively establish such a link." -11213963,Prednisolone related to leprosy,240,"Prednisolone treatment of sensory impairment of the ulnar and posterior tibial nerves detectable with the monofilament test, but not with the ballpen test, did not improve the long-term outcome in terms of recovery of touch sensibility, not did it reduce the risk of leprosy reactions or nerve function impairment beyond the initial 4-month treatment phase.",False,"Is the triple 'Prednisolone related to leprosy' supported by the sentence: 'Prednisolone treatment of sensory impairment of the ulnar and posterior tibial nerves detectable with the monofilament test, but not with the ballpen test, did not improve the long-term outcome in terms of recovery of touch sensibility, not did it reduce the risk of leprosy reactions or nerve function impairment beyond the initial 4-month treatment phase.'?","No, the statement does not provide indirect support for the phrase ""Prednisolone related to leprosy."" The statement discusses the effects of Prednisolone treatment on sensory impairment and leprosy reactions or nerve function impairment, but it does not establish a direct relationship between Prednisolone and leprosy itself. Therefore, based on this information alone, one cannot infer that Prednisolone is related to leprosy in any way." -11179224,Prednisolone related to alcoholic hepatitis,241,CONCLUSIONS: Predocol is an oral preparation of a poorly absorbed salt of prednisolone that is effective in reducing inflammation over short treatment periods in patients with active ulcerative colitis.,False,Is the triple 'Prednisolone related to alcoholic hepatitis' supported by the sentence: 'CONCLUSIONS: Predocol is an oral preparation of a poorly absorbed salt of prednisolone that is effective in reducing inflammation over short treatment periods in patients with active ulcerative colitis.'?,"No, the statement does not provide indirect support for the phrase ""Prednisolone related to alcoholic hepatitis."" The conclusion is about Prednisolone being effective in treating ulcerative colitis, which is an inflammatory bowel disease. There is no mention or implication of alcoholic hepatitis in this statement. Alcoholic hepatitis is a liver condition caused by excessive consumption of alcohol over time. Prednisolone may be used in treating various inflammatory conditions but is not specifically related to alcoholic hepatitis based on this information alone." -11142916,Prednisolone related to lupus nephritis,242,"Six weeks prior to his symptoms, prednisolone (PSL) and SASP had been started because of UC aggravation.",False,"Is the triple 'Prednisolone related to lupus nephritis' supported by the sentence: 'Six weeks prior to his symptoms, prednisolone (PSL) and SASP had been started because of UC aggravation.'?","No, the statement ""Six weeks prior to his symptoms, prednisolone (PSL) and SASP had been started because of UC aggravation"" does not provide direct or indirect support for the phrase ""Prednisolone related to lupus nephritis"". The statement only indicates that prednisolone was administered due to ulcerative colitis (UC) aggravation, not lupus nephritis. The connection between prednisolone use and lupus nephritis has not been established in this statement." -11037266,Prednisolone related to granulomatosis with polyangiitis,243,"When comparing organ specific, age-adjusted expected versus observed incidences after natural death of animals an increased tumor risk was found in organ systems of all treatment modalities but prednisolone.",False,"Is the triple 'Prednisolone related to granulomatosis with polyangiitis' supported by the sentence: 'When comparing organ specific, age-adjusted expected versus observed incidences after natural death of animals an increased tumor risk was found in organ systems of all treatment modalities but prednisolone.'?","No, the statement does not provide indirect support for the phrase ""Prednisolone related to granulomatosis with polyangiitis"". The provided statement discusses an increased tumor risk in organ systems associated with various treatment modalities compared to natural death in animals, one of which is prednisolone. However, it does not establish any connection between prednisolone and granulomatosis with polyangiitis (GPA). + The statement discusses Hydrocortisone infusion in septic shock and its effect on cytokine responses. Hydrocortisone, Prednisolone, and Prednisone are all corticosteroids, but they are not identical compounds. They have different chemical structures and pharmacological properties. - Granulomatosis with polyangiitis is an autoimmune disease characterized by inflammation in blood vessels, often affecting the respiratory system and kidneys. Prednisolone is a corticosteroid medication commonly used in treating GPA due to its potent anti-inflammatory properties. However, the statement only addresses prednisolone as a risk factor for tumor development in animals, which does not necessarily imply any relationship between prednisolone and GPA in humans. + Even if there were evidence of an interaction between Hydrocortisone and either Prednisolone or Prednisone, it would not necessarily imply an interaction between Prednisolone and Prednisone themselves. - In summary, while prednisolone may have various clinical applications, including GPA treatment, the statement does not provide any indirect support for prednisolone being related to GPA due to its focus on tumor risk in animals rather than GPA inc" -11013570,Prednisolone related to leukemia,244,"R-CHOP chemotherapy composed of rituximab, cyclophosphamide, adriamycin, vincristine, and prednisolone which might increase the risk of Pneumocystis pneumonia in patients with non-Hodgkin lymphoma.",False,"Is the triple 'Prednisolone related to leukemia' supported by the sentence: 'R-CHOP chemotherapy composed of rituximab, cyclophosphamide, adriamycin, vincristine, and prednisolone which might increase the risk of Pneumocystis pneumonia in patients with non-Hodgkin lymphoma.'?","No, the statement does not provide direct or indirect support for the phrase ""Prednisolone related to leukemia."" The statement discusses R-CHOP chemotherapy as a treatment for non-Hodgkin lymphoma, which includes prednisolone as one of its components. It then mentions that such therapy might increase the risk of Pneumocystis pneumonia in patients. Although prednisolone has been linked to various side effects due to its immunosuppressive nature, there is no connection established in this statement between prednisolone and leukemia. Leukemia is a type of cancer that originates in blood-forming tissues, whereas prednisolone is primarily used as an anti-inflammatory and immunosuppressive drug in cancer treatments but does not cause leukemia." -10949449,Prednisolone related to polymyalgia rheumatica,245,"Cortisol deficiency is common in late stage HIV disease, but symptoms of fatigue and postural hypotension, as well as biochemical findings, are poor predictors of cortisol deficiency.",False,"Is the triple 'Prednisolone related to polymyalgia rheumatica' supported by the sentence: 'Cortisol deficiency is common in late stage HIV disease, but symptoms of fatigue and postural hypotension, as well as biochemical findings, are poor predictors of cortisol deficiency.'?","No, the statement does not provide indirect support for the phrase ""Prednisolone related to polymyalgia rheumatica."" The connection between cortisol deficiency in late-stage HIV disease and polymyalgia rheumatica is not evident in the provided statement. The statement focuses on cortisol deficiency in late-stage HIV disease and its poor correlation with symptoms and biochemical findings. Prednisolone is commonly used as an anti-inflammatory agent in treating polymyalgia rheumatica, an autoimmune disorder characterized by muscle pain and stiffness in the shoulders and hips. The statement does not mention Prednisolone nor polymyalgia rheumatica; thus, it does not offer indirect support for their connection." -10748640,Prednisolone related to infertility disorder,246,[Plasma cortisol and 17-ketosteroids in urine in relation to cardiac arrest].,False,Is the triple 'Prednisolone related to infertility disorder' supported by the sentence: '[Plasma cortisol and 17-ketosteroids in urine in relation to cardiac arrest].'?,"No, the statement ""Prednisolone related to infertility disorder"" does not receive indirect support from the provided statement: ""[Plasma cortisol and 17-ketosteroids in urine in relation to cardiac arrest]."" + Therefore, without additional evidence specifically pertaining to Prednisolone and Prednisone, it is not possible to conclude that there is any physical interaction between these two compounds based on the provided statement." +9296682,Prednisolone physically interacts with Prednisone,279,"BACKGROUND: There is substantial evidence of dysregulation of cortisol secretion, hippocampal abnormalities, and memory deficits in schizophrenia and other psychotic disorders.",False,"'Does the phrase ""Prednisolone physically interacts with Prednisone"" receive at least indirect support from the statement: ""BACKGROUND: There is substantial evidence of dysregulation of cortisol secretion, hippocampal abnormalities, and memory deficits in schizophrenia and other psychotic disorders.""?","No, the statement does not provide indirect support for the phrase ""Prednisolone physically interacts with Prednisone."" - The provided statement discusses Plasma cortisol and 17-ketosteroids in urine in relation to cardiac arrest. Prednisolone is a synthetic glucocorticoid which is structurally similar to cortisol (a type of glucocorticoid) but it is not mentioned in the statement. Also there is no mention of infertility disorder in the statement. Therefore we can not infer any relation between Prednisolone and infertility disorder from it. + The background statement discusses dysregulation of cortisol secretion, hippocampal abnormalities, and memory deficits in schizophrenia and other psychotic disorders. While both Prednisolone and Prednisone are corticosteroids that can influence cortisol secretion, the statement does not mention or imply any direct or indirect interaction between these two substances. - It is important to note that infertility is a complex disorder that can be caused by various factors including genetic, environmental, hormonal imbalances etc. Prednisolone is primarily used as an anti-inflammatory drug but it can have side effects on various organ systems including reproductive system which can lead to infertility but that would require further investigation and direct evidence." -10744705,"Prednisolone related to dermatitis, atopic",247,"Independence of theta and TL surface antigens and killing by thymidine, cortisol, phytohemagglutinin, and cyclic AMP in a murine lymphoma.",False,"Is the triple 'Prednisolone related to dermatitis, atopic' supported by the sentence: 'Independence of theta and TL surface antigens and killing by thymidine, cortisol, phytohemagglutinin, and cyclic AMP in a murine lymphoma.'?","No, the statement ""Independence of theta and TL surface antigens and killing by thymidine, cortisol, phytohemagglutinin, and cyclic AMP in a murine lymphoma"" does not provide indirect support for the phrase ""Prednisolone related to dermatitis, atopic"". + Prednisolone and Prednisone are structurally similar and metabolically related, but they do not physically interact in a way that one could alter the other's chemical structure or function in vivo or in vitro. They can compete for binding sites (such as glucocorticoid receptors), but that is not explicitly stated in the background information provided. - The statement discusses the independence of certain surface antigens (theta and TL) and the killing effect of various substances (thymidine, cortisol, phytohemagglutinin, and cyclic AMP) on murine lymphoma cells. Prednisolone is not mentioned in this statement, nor is there any connection made to dermatitis, atopic or any other skin conditions. Therefore, it does not offer any form of support for the given phrase." -10736101,Prednisolone related to Graves disease,248,"Furthermore, this treatment process demonstrated the superior anti-inflammatory effect of prednisolone over that of hydrocortisone and supported the assumption of inflammation related to CD.",True,"Is the triple 'Prednisolone related to Graves disease' supported by the sentence: 'Furthermore, this treatment process demonstrated the superior anti-inflammatory effect of prednisolone over that of hydrocortisone and supported the assumption of inflammation related to CD.'?","Yes, indirectly it does lend some support. The statement suggests that prednisolone has a superior anti-inflammatory effect compared to hydrocortisone and supports the assumption that inflammation is related to CD (presumably an abbreviation for a condition or disease). Graves disease is indeed associated with inflammation, so if we assume that CD refers to Graves disease in this context, then the statement does provide indirect support for the connection between prednisolone and Graves disease. However, it's important to note that this is an indirect inference and does not provide direct evidence of a causal relationship between prednisolone and Graves disease. Further investigation would be required to establish such a link conclusively." -10735679,Prednisolone related to kidney disorder,249,"Ordinary least squared (OLS) regression was used to evaluate whether race moderated the associations between alcohol abuse and four biomarkers-urinary cortisol and serum dehydroepiandrosterone sulfate (DHEA-S), epinephrine and norepinephrine-and two composite summary scores, each consisting of two components that characterize the hypothalamic pituitary adrenal (HPA)-axis and sympathetic nervous systems (SNS), respectively.",False,"Is the triple 'Prednisolone related to kidney disorder' supported by the sentence: 'Ordinary least squared (OLS) regression was used to evaluate whether race moderated the associations between alcohol abuse and four biomarkers-urinary cortisol and serum dehydroepiandrosterone sulfate (DHEA-S), epinephrine and norepinephrine-and two composite summary scores, each consisting of two components that characterize the hypothalamic pituitary adrenal (HPA)-axis and sympathetic nervous systems (SNS), respectively.'?","No, the statement does not provide direct or indirect support for the phrase ""Prednisolone related to kidney disorder."" The provided statement discusses an OLS regression analysis that evaluated whether race moderated the associations between alcohol abuse and four biomarkers related to the HPA-axis and SNS systems. Prednisolone is not mentioned in the statement, nor is there any connection made between alcohol abuse, kidney disorder, or any related biological systems." -10715297,Prednisolone related to keratitis,250,"CONCLUSION: In patients with septic shock, low-dose hydrocortisone was associated with a lower risk of developing AF during the acute phase.",False,"Is the triple 'Prednisolone related to keratitis' supported by the sentence: 'CONCLUSION: In patients with septic shock, low-dose hydrocortisone was associated with a lower risk of developing AF during the acute phase.'?","No, the statement ""Prednisolone related to keratitis"" does not receive indirect support from the conclusion provided in the study about septic shock patients and low-dose hydrocortisone use. The conclusion in question focuses on the association between low-dose hydrocortisone and atrial fibrillation (AF) risk in septic shock patients during the acute phase. + In conclusion, while both Prednisolone and Prednisone have similar mechanisms of action related to cortisol regulation, there is no evidence in the given statement suggesting they physically interact in any way that would support the initial phrase." +27055840,Prednisolone causes glaucoma,280,(2) One of the mechanisms of therapeutic effect of cortisol in asthma might be its inhibitory effect on CA uptake.,False,"'Does the phrase ""Prednisolone causes glaucoma"" receive at least indirect support from the statement: ""(2) One of the mechanisms of therapeutic effect of cortisol in asthma might be its inhibitory effect on CA uptake.""?","No, the statement does not provide indirect support for the phrase ""Prednisolone causes glaucoma."" Prednisolone is a synthetic glucocorticoid, similar to cortisol, often used in treating inflammatory diseases such as asthma. The mechanism mentioned in the statement refers to cortisol's inhibitory effect on cyclooxygenase (COX) activity, which is involved in inflammation regulation. - The two statements involve different medical conditions (septic shock vs keratitis), drug treatments (low-dose hydrocortisone vs prednisolone), and outcomes (AF risk vs keratitis incidence). As such, there is no clear connection between them that would lend indirect support to the claim about prednisolone being related to keratitis based on the provided conclusion about low-dose hydrocortisone in septic shock patients. + Glaucoma is an optic neuropathy characterized by increased intraocular pressure (IOP) leading to optic nerve damage and vision loss. The relationship between corticosteroids (including Prednisolone) and glaucoma is complex. While topical corticosteroids can increase IOP in some individuals predisposed to glaucoma, it does not necessarily mean that Prednisolone causes glaucoma in all cases. - To establish an indirect link between prednisolone use and keratitis risk, one would need evidence from studies involving prednisolone specifically and its association with keratitis incidence. Therefore, further investigation is necessary before making any conclusions about prednisolone being related to keratitis based on existing evidence related to other cortic" -10703266,Prednisolone related to ulcerative colitis,251,"The incidence of psychological symptoms as somatization, obsessive-compulsive symptoms, depression, anxiety, phobia, and nonspecific symptoms is statistically increased in pregnant women with elevated morning cortisol, but in women with elevated afternoon cortisol also occurring aggressiveness and paranoia.",False,"Is the triple 'Prednisolone related to ulcerative colitis' supported by the sentence: 'The incidence of psychological symptoms as somatization, obsessive-compulsive symptoms, depression, anxiety, phobia, and nonspecific symptoms is statistically increased in pregnant women with elevated morning cortisol, but in women with elevated afternoon cortisol also occurring aggressiveness and paranoia.'?","No, the statement does not provide direct or indirect support for the phrase ""Prednisolone related to ulcerative colitis."" + Therefore, without further evidence linking Prednisolone use specifically to glaucoma development, one cannot infer that the mentioned mechanism provides indirect support for that claim." +26677891,Prednisolone causes uveitis,281,"OBJECTIVE: To compare cortisol levels, diurnal cycles of cortisol, and reactivity of cortisol to psychological stress in fibromyalgia (FM) and rheumatoid arthritis (RA) patients in their natural environment, and to examine the effect on results of accounting for differences among the groups in psychological stress and other lifestyle and psychosocial variables.",False,"'Does the phrase ""Prednisolone causes uveitis"" receive at least indirect support from the statement: ""OBJECTIVE: To compare cortisol levels, diurnal cycles of cortisol, and reactivity of cortisol to psychological stress in fibromyalgia (FM) and rheumatoid arthritis (RA) patients in their natural environment, and to examine the effect on results of accounting for differences among the groups in psychological stress and other lifestyle and psychosocial variables.""?","No, the statement does not provide indirect support for the phrase ""Prednisolone causes uveitis."" The objective of the study mentioned is focused on comparing cortisol levels, diurnal cycles of cortisol, and reactivity of cortisol to psychological stress in fibromyalgia (FM) and rheumatoid arthritis (RA) patients in their natural environment while accounting for differences among these groups in psychological stress and other lifestyle and psychosocial variables. - The statement discusses the psychological symptoms associated with elevated cortisol levels in pregnant women, specifically differentiating between morning and afternoon cortisol levels. Prednisolone is a synthetic glucocorticoid often used in treating various conditions such as ulcerative colitis, asthma, rheumatoid arthritis, and other autoimmune diseases due to its anti-inflammatory properties. + Prednisolone is a synthetic glucocorticoid used primarily for its anti-inflammatory properties in treating various conditions such as rheumatoid arthritis; however, it is not mentioned in the study objective provided. Uveitis is an inflammation of the uvea—the middle layer of the eye—which can have various causes including infections, injuries, autoimmune diseases, and sometimes medications like corticosteroids (including prednisolone). However, without any direct mention of prednisolone in relation to uveitis in the given statement, it does not provide indirect support for that specific claim." +25953223,Prednisolone causes kidney disorder,282,"OBJECTIVES: Recent data suggest that higher plasma cortisol may be associated with hypertension and insulin resistance in otherwise healthy men, as it is in Cushing's syndrome.",False,"'Does the phrase ""Prednisolone causes kidney disorder"" receive at least indirect support from the statement: ""OBJECTIVES: Recent data suggest that higher plasma cortisol may be associated with hypertension and insulin resistance in otherwise healthy men, as it is in Cushing's syndrome.""?","No, the statement does not provide indirect support for the phrase ""Prednisolone causes kidney disorder."" The objective provided focuses on the potential associations between higher plasma cortisol levels and hypertension as well as insulin resistance in healthy men, which is comparable to Cushing's syndrome. Although Prednisolone is a glucocorticoid that can increase cortisol levels in the body, the objective does not mention any connection to kidney disorders. Therefore, without additional context or evidence linking Prednisolone use to kidney issues, one cannot infer that Prednisolone causes kidney disorder based solely on this objective statement." +21556285,Prednisolone causes allergic disease,283,"These findings demonstrate 2 types of adrenal insufficiency with different clinical pictures: Type 1 is characterized by cortisol deficiency with hypoglycaemia, low corticoid levels and a low cortisol secretion rate; Type 2 shows aldosterone deficiency with prominent salt loss.",False,"'Does the phrase ""Prednisolone causes allergic disease"" receive at least indirect support from the statement: ""These findings demonstrate 2 types of adrenal insufficiency with different clinical pictures: Type 1 is characterized by cortisol deficiency with hypoglycaemia, low corticoid levels and a low cortisol secretion rate; Type 2 shows aldosterone deficiency with prominent salt loss.""?","No, the statement does not provide indirect support for the phrase ""Prednisolone causes allergic disease."" The statement discusses two types of adrenal insufficiency and their associated characteristics but does not mention Prednisolone or allergic disease. Prednisolone is a synthetic glucocorticoid hormone used in various medical treatments, including allergic reactions; however, no connection is drawn between Prednisolone and allergic disease in this statement." +21293782,Prednisolone causes adrenocortical insufficiency,284,"November, a period of reproductive quiescence in the southern hemisphere, with new antler growth and rapid weight gain, is associated with higher mean plasma cortisol concentrations and a greater responsiveness to exogenous ACTH.",False,"'Does the phrase ""Prednisolone causes adrenocortical insufficiency"" receive at least indirect support from the statement: ""November, a period of reproductive quiescence in the southern hemisphere, with new antler growth and rapid weight gain, is associated with higher mean plasma cortisol concentrations and a greater responsiveness to exogenous ACTH.""?","No, the statement does not provide indirect support for the phrase ""Prednisolone causes adrenocortical insufficiency."" - Although cortisol is another glucocorticoid like Prednisolone, no direct connection is established between Prednisolone use for ulcerative colitis and cortisol levels in pregnant women in this statement. Therefore, it does not provide any support for the phrase ""Prednisolone related to ulcerative colitis.""" -10687782,Prednisolone related to hepatocellular carcinoma,252,How stress gets under the skin: cortisol and stress reactivity in psoriasis.,False,Is the triple 'Prednisolone related to hepatocellular carcinoma' supported by the sentence: 'How stress gets under the skin: cortisol and stress reactivity in psoriasis.'?,"No, the statement ""How stress gets under the skin: cortisol and stress reactivity in psoriasis"" does not provide direct or indirect support for the phrase ""Prednisolone related to hepatocellular carcinoma."" + Prednisolone is a synthetic glucocorticoid often used in clinical settings for its anti-inflammatory effects. Adrenocortical insufficiency refers to the inadequate production of corticosteroids by the adrenal glands, which can be caused by prolonged exposure to exogenous glucocorticoids like Prednisolone—a phenomenon known as iatrogenic Cushing's syndrome. - + The provided statement discusses higher mean plasma cortisol concentrations and greater responsiveness to exogenous ACTH during November in the southern hemisphere. Cortisol is one of the primary stress hormones produced by the adrenal glands in response to ACTH stimulation from the pituitary gland; thus, an increase in cortisol levels could indicate heightened stress or activation of the hypothalamic-pituitary-adrenal (HPA) axis rather than adrenocortical insufficiency. - Prednisolone is a synthetic glucocorticoid hormone used primarily for its anti-inflammatory effects, while hepatocellular carcinoma is a type of liver cancer. Although both prednisolone and stress (which can increase cortisol levels) have been linked to liver damage in some studies, there is no direct connection between prednisolone use and hepatocellular carcinoma specifically in the provided statement. + Furthermore, there is no mention of Prednisolone" +20789636,Prednisolone causes ulcerative colitis,285,Cortisol metabolism in human obesity: impaired cortisone-->cortisol conversion in subjects with central adiposity.,False,"'Does the phrase ""Prednisolone causes ulcerative colitis"" receive at least indirect support from the statement: ""Cortisol metabolism in human obesity: impaired cortisone-->cortisol conversion in subjects with central adiposity.""?","No, the statement does not provide indirect support for the phrase ""Prednisolone causes ulcerative colitis."" - + Prednisolone is a synthetic glucocorticoid hormone similar to cortisol, which is primarily used for its anti-inflammatory effects in various medical conditions such as asthma, rheumatoid arthritis, inflammatory bowel diseases (including ulcerative colitis), and certain skin disorders. The statement in question discusses cortisol metabolism in human obesity without mentioning prednisolone or ulcerative colitis; hence it does not offer any indirect support for the claim in question. - The statement focuses on cortisol (a stress hormone) and stress reactivity in psoriasis patients, rather than prednisolone use or hepatocellular carcinoma. Cortisol has complex effects on inflammation and immune response modulation, but it is not equivalent to prednisolone in terms of pharmacological action or cancer risk. + However, it is important to note that long-term use of glucocorticoids like prednisolone has been associated with side effects such as increased risk of infections, osteoporosis, hyperglycemia, mood changes, and gastrointestinal issues (including peptic ulcers). Nonetheless, these side effects result from chronic exposure and improper usage of such medications rather than being causative agents for ulcerative colitis. - + In conclusion, while prednis" +17230021,Prednisolone causes Headache,286,The hypothalamic-pituitary-adrenal (HPA) axis is one of the key physiological systems that counterbalances this systemic inflammation through changes in adrenocorticotrophic hormone (ACTH) and cortisol.,False,"'Does the phrase ""Prednisolone causes Headache"" receive at least indirect support from the statement: ""The hypothalamic-pituitary-adrenal (HPA) axis is one of the key physiological systems that counterbalances this systemic inflammation through changes in adrenocorticotrophic hormone (ACTH) and cortisol.""?","No, the statement does not provide direct or indirect support for the claim that Prednisolone causes headaches. The statement discusses the hypothalamic-pituitary-adrenal (HPA) axis's role in counteracting systemic inflammation through changes in adrenocorticotrophic hormone (ACTH) and cortisol levels. Prednisolone is indeed a synthetic glucocorticoid that acts on the HPA axis by mimicking cortisol's effects on target cells; however, it does not necessarily imply that Prednisolone causes headaches as a side effect. While headaches can be one of many potential side effects of Prednisolone, additional evidence would be required to establish a direct causal relationship between Prednisolone use and headaches specifically." +16304261,Prednisolone causes nephrotic syndrome,287,"The 5 dpf hypoxic exposure also elicited transient increases in whole body cortisol and in crf, uts1, and hsd20b2 expression, key regulators of the endocrine stress response.",False,"'Does the phrase ""Prednisolone causes nephrotic syndrome"" receive at least indirect support from the statement: ""The 5 dpf hypoxic exposure also elicited transient increases in whole body cortisol and in crf, uts1, and hsd20b2 expression, key regulators of the endocrine stress response.""?","No, the statement does not provide direct or indirect support for the claim that Prednisolone causes nephrotic syndrome. The statement discusses the effects of hypoxic exposure on zebrafish development at 5 days post-fertilization (dpf), including increased whole-body cortisol levels and upregulated expression of certain corticotropin-release factor (crf), urotensin-I (uts1), and 20β-hydroxysteroid dehydrogenase (hsd20b2) genes involved in the endocrine stress response. However, there is no mention of Prednisolone in the statement nor any connection made between hypoxic exposure, cortisol regulation, or these gene expressions in relation to nephrotic syndrome development." +15365269,Prednisolone causes infertility disorder,288,"At multiple regression analyses, HOMA-IR on admission in the IR group significantly correlated with thyroid-stimulating hormone, glucagon, and cortisol.",False,"'Does the phrase ""Prednisolone causes infertility disorder"" receive at least indirect support from the statement: ""At multiple regression analyses, HOMA-IR on admission in the IR group significantly correlated with thyroid-stimulating hormone, glucagon, and cortisol.""?","No, the statement does not provide indirect support for the phrase ""Prednisolone causes infertility disorder."" The provided statement discusses correlations between HOMA-IR (Homeostatic Model Assessment for Insulin Resistance) on admission in an insulin resistance (IR) group with thyroid-stimulating hormone, glucagon, and cortisol levels. While Prednisolone is a type of corticosteroid that can influence cortisol levels, there is no mention of Prednisolone in the statement, nor is there any direct or indirect link established between cortisol levels and infertility disorder. Therefore, it is not possible to infer that Prednisolone causes infertility disorder based on this information alone. However, it is essential to consider further evidence in order to draw more definitive conclusions about any potential relationships between Prednisolone use, cortisol levels, and infertility disorder." +14373522,Prednisolone causes exfoliative dermatitis,289,"The suppression of the anti-inflammatory effects of cortisol as a result of states of excessive stress leads to hypercatabolic diseases such as AIDS, sepsis and toxic shock syndrome and protein calorie malnutrition (NAIDS).",False,"'Does the phrase ""Prednisolone causes exfoliative dermatitis"" receive at least indirect support from the statement: ""The suppression of the anti-inflammatory effects of cortisol as a result of states of excessive stress leads to hypercatabolic diseases such as AIDS, sepsis and toxic shock syndrome and protein calorie malnutrition (NAIDS).""?","No, the statement does not provide indirect support for the phrase ""Prednisolone causes exfoliative dermatitis."" - In conclusion, while both prednisolone" -10623724,Prednisolone related to hemolytic anemia,253,Absorption of hydrocortisone from the skin reservoir in atopic dermatitis.,False,Is the triple 'Prednisolone related to hemolytic anemia' supported by the sentence: 'Absorption of hydrocortisone from the skin reservoir in atopic dermatitis.'?,"No, the statement ""Absorption of hydrocortisone from the skin reservoir in atopic dermatitis"" does not provide indirect support for the phrase ""Prednisolone related to hemolytic anemia."" + The statement discusses the suppression of anti-inflammatory effects of cortisol in states of excessive stress leading to hypercatabolic diseases such as AIDS, sepsis, toxic shock syndrome, and protein calorie malnutrition (NAIDS). Prednisolone is a synthetic glucocorticoid drug that acts similarly to cortisol in suppressing inflammation; however, it is not explicitly mentioned in this statement as causing exfoliative dermatitis. - These two statements pertain to different corticosteroids (hydrocortisone vs prednisolone) and different medical conditions (atopic dermatitis vs hemolytic anemia). While both hydrocortisone and prednisolone can cause side effects such as hemolytic anemia due to their immunosuppressive properties, one statement does not imply or support the other in any way. + Exfoliative dermatitis is characterized by inflammation of the skin leading to scaling and shedding of large areas of skin; it can be caused by various factors like medications (including corticosteroids), infections, cancer, autoimmune disorders, and genetic conditions. Although Prednisolone can cause skin issues such as thinning of the skin, acne, and increased vulnerability to infections due to its immunosuppressive nature, it does not necessarily mean that it causes exfoliative dermatitis specifically. - The absorption of hydrocortisone from the skin reservoir in atopic dermatitis is related to the drug delivery method and its efficacy in treating atopic dermatitis, not its potential side effects like hemolytic anemia. Hemolytic anemia as a side effect would depend on factors such as dosage, duration of treatment, patient characteristics, and pharmacogenetics rather than the route of administration alone. + Therefore, without" +10735861,Prednisolone causes contact dermatitis,290,"The suppression of the anti-inflammatory effects of cortisol as a result of states of excessive stress leads to hypercatabolic diseases such as AIDS, sepsis and toxic shock syndrome and protein calorie malnutrition (NAIDS).",False,"'Does the phrase ""Prednisolone causes contact dermatitis"" receive at least indirect support from the statement: ""The suppression of the anti-inflammatory effects of cortisol as a result of states of excessive stress leads to hypercatabolic diseases such as AIDS, sepsis and toxic shock syndrome and protein calorie malnutrition (NAIDS).""?","No, the statement does not provide indirect support for the phrase ""Prednisolone causes contact dermatitis."" - Therefore, further evidence would be required to" -10576837,Prednisolone related to juvenile idiopathic arthritis,254,OBJECTIVE: To assess dexamethasone (DEX) and hydrocortisone (HC) use in premature infants over time and the association of steroid use with the incidence of bronchopulmonary dysplasia (BPD) at 36 weeks' postmenstrual age.,False,Is the triple 'Prednisolone related to juvenile idiopathic arthritis' supported by the sentence: 'OBJECTIVE: To assess dexamethasone (DEX) and hydrocortisone (HC) use in premature infants over time and the association of steroid use with the incidence of bronchopulmonary dysplasia (BPD) at 36 weeks' postmenstrual age.'?,"No, the statement does not provide indirect support for the phrase ""Prednisolone related to juvenile idiopathic arthritis."" The objective in the statement is focused on assessing dexamethasone (DEX) and hydrocortisone (HC) use in premature infants over time and their association with bronchopulmonary dysplasia (BPD) at 36 weeks postmenstrual age. Prednisolone is not mentioned in the statement, nor is there any connection made between steroid use in premature infants and juvenile idiopathic arthritis." -10565620,Prednisolone related to nephrotic syndrome,255,Increased ratio of mRNA expression of the genes CYP17 and CYP11B1 indicates autonomous cortisol production in adrenocortical tumors.,False,Is the triple 'Prednisolone related to nephrotic syndrome' supported by the sentence: 'Increased ratio of mRNA expression of the genes CYP17 and CYP11B1 indicates autonomous cortisol production in adrenocortical tumors.'?,"No, the statement does not provide direct or indirect support for the phrase ""Prednisolone related to nephrotic syndrome."" + Prednisolone is a synthetic glucocorticoid hormone that is often used in medical treatments for its anti-inflammatory effects. The statement provided discusses the suppression of anti-inflammatory effects of cortisol due to excessive stress leading to certain diseases (NAIDS). While both cortisol and prednisolone have anti-inflammatory effects, they are distinct entities; cortisol is a natural hormone produced in the human body while prednisolone is a synthetic drug. - Prednisolone is a synthetic glucocorticoid often used in treating nephrotic syndrome, but it is not explicitly mentioned in the given statement about CYP17 and CYP11B1 mRNA expression ratios in adrenocortical tumors. The statement refers specifically to cortisol production in adrenocortical tumors, not Prednisolone use or nephrotic syndrome. + Contact dermatitis is an inflammatory reaction of the skin resulting from exposure to an allergen or irritant. Although glucocorticoids like prednisolone can be used in treating contact dermatitis due to their anti-inflammatory properties, they can also cause adverse reactions such as skin thinning and increased susceptibility to infections when used over prolonged periods. However, these potential adverse effects do not directly imply that prednisolone causes contact dermatitis as an allergic reaction; it" +10545904,Prednisolone causes pulmonary tuberculosis,291,"We report the case of a 41-year-old nonatopic women with a previous history of eczematous reaction due to hydrocortisone who suffered worsening of her perennial rhinitis in association with perinasal dermatitis from the use of budesonide in nasal spray form, and stomatitis and pharyngitis due to budesonide in a bronchial inhaler.",False,"'Does the phrase ""Prednisolone causes pulmonary tuberculosis"" receive at least indirect support from the statement: ""We report the case of a 41-year-old nonatopic women with a previous history of eczematous reaction due to hydrocortisone who suffered worsening of her perennial rhinitis in association with perinasal dermatitis from the use of budesonide in nasal spray form, and stomatitis and pharyngitis due to budesonide in a bronchial inhaler.""?","No, the statement does not provide indirect support for the phrase ""Prednisolone causes pulmonary tuberculosis."" The case report describes an individual who experienced adverse effects from using budesonide, a different corticosteroid than prednisolone. The patient had a history of eczematous reaction due to hydrocortisone but developed new symptoms after using budesonide in nasal spray form and bronchial inhaler form. There is no mention of prednisolone in the statement, nor any connection made between prednisolone use and pulmonary tuberculosis. - The connection between Prednisolone and nephrotic syndrome is well-established in medical literature; however, without further evidence linking cortisol production in adrenocortical tumors (as indicated by CYP17 and CYP11B1 mRNA expression ratios) to Prednisolone use in nephrotic syndrome patients, it would be inappropriate to infer any relationship between them based on the provided statement alone." -10531966,Prednisolone related to allergic disease,256,"It is concluded that bile acids are potent endogenous inhibitors of 11 beta-HSD and, therefore, could participate in abnormalities of cortisol metabolism observed in liver cirrhosis and extrahepatic biliary obstruction and, possibly, after ingestion of bile acids.",False,"Is the triple 'Prednisolone related to allergic disease' supported by the sentence: 'It is concluded that bile acids are potent endogenous inhibitors of 11 beta-HSD and, therefore, could participate in abnormalities of cortisol metabolism observed in liver cirrhosis and extrahepatic biliary obstruction and, possibly, after ingestion of bile acids.'?","No, the statement ""It is concluded that bile acids are potent endogenous inhibitors of 11 beta-HSD and, therefore, could participate in abnormalities of cortisol metabolism observed in liver cirrhosis and extrahepatic biliary obstruction and, possibly, after ingestion of bile acids."" does not provide indirect support for the phrase ""Prednisolone related to allergic disease."" + To provide indirect support for the claim that ""Prednisolone causes pulmonary tuberculosis,"" there would need to be some evidence suggesting an association between prednisolone use and an increased risk of pulmonary tuberculosis development. However, in this statement, there is no such evidence presented." +10519611,Prednisolone causes colitis,292,"In this perspective paper, we focus on the neuro-endocrine interactions that occur between progesterone, allopregnanolone, and cortisol during pregnancy, and propose that they align with our previously proposed model of FM pathogenesis based on GABAergic ""weakening"" in a thalamocortical neural loop system.",False,"'Does the phrase ""Prednisolone causes colitis"" receive at least indirect support from the statement: ""In this perspective paper, we focus on the neuro-endocrine interactions that occur between progesterone, allopregnanolone, and cortisol during pregnancy, and propose that they align with our previously proposed model of FM pathogenesis based on GABAergic ""weakening"" in a thalamocortical neural loop system.""?","No, the statement does not provide indirect support for the phrase ""Prednisolone causes colitis."" The focus of the perspective paper is on neuro-endocrine interactions during pregnancy involving progesterone, allopregnanolone, and cortisol, along with their proposed relationship to fibromyalgia (FM) pathogenesis based on GABAergic weakening in a thalamocortical neural loop system. Prednisolone is a synthetic glucocorticoid used primarily for its potent anti-inflammatory properties and is unrelated to the hormones discussed in the paper. Therefore, there is no connection between the statement and Prednisolone causing colitis." +9464043,Prednisolone causes cataract,293,The present study reported a case of hydrocortisone-induced blood pressure reduction in a patient with anterior pituitary hypofunction due to allergic reaction.,False,"'Does the phrase ""Prednisolone causes cataract"" receive at least indirect support from the statement: ""The present study reported a case of hydrocortisone-induced blood pressure reduction in a patient with anterior pituitary hypofunction due to allergic reaction.""?","No, the statement does not provide indirect support for the phrase ""Prednisolone causes cataract"". The study mentioned in the statement investigates hydrocortisone-induced blood pressure reduction in a patient with anterior pituitary hypofunction due to an allergic reaction. Hydrocortisone and prednisolone belong to the same class of medications (glucocorticoids), but they are different drugs that can have different side effects profiles. The study does not mention cataracts or any ocular side effects related to hydrocortisone use; therefore, it does not provide evidence for prednisolone causing cataracts either. - The statement discusses the role of bile acids as inhibitors of 11 beta-HSD (11-beta-hydroxysteroid dehydrogenase), an enzyme involved in cortisol metabolism. The inhibition of 11 beta-HSD can lead to abnormalities in cortisol metabolism in conditions like liver cirrhosis, extrahepatic biliary obstruction, and after ingestion of bile acids. + To provide indirect support for ""Prednisolone causes cataract,"" there should be some connection between prednisolone use and cataract development in the statement. However, in this case, no such connection is present. It is essential to base conclusions on solid evidence that directly supports the claim in question. - Prednisolone is a synthetic glucocorticoid used primarily for its anti-inflammatory and immunosuppressive effects in various medical conditions such as allergies, asthma, autoimmune diseases, and certain types" -10527508,Prednisolone related to acute myeloid leukemia,257,"The plasma cortisol concentration was significantly higher in both DD groups before treatment than in the control group, and it decreased significantly after hoof trimming in the trimmed group.",False,"Is the triple 'Prednisolone related to acute myeloid leukemia' supported by the sentence: 'The plasma cortisol concentration was significantly higher in both DD groups before treatment than in the control group, and it decreased significantly after hoof trimming in the trimmed group.'?","No, the statement does not provide indirect support for the phrase ""Prednisolone related to acute myeloid leukemia."" The statement discusses changes in plasma cortisol concentration in response to hoof trimming in different groups but does not mention Prednisolone or acute myeloid leukemia at all. Prednisolone is a synthetic glucocorticoid often used as an anti-inflammatory agent, while acute myeloid leukemia is a type of cancer affecting blood cells; thus, there is no connection between them in this context." -10503828,Prednisolone related to seasonal allergic rhinitis,258,Hydrocortisone in culture protects the blast cells in acute myeloblastic leukemia from the lethal effects of cytosine arabinoside.,False,Is the triple 'Prednisolone related to seasonal allergic rhinitis' supported by the sentence: 'Hydrocortisone in culture protects the blast cells in acute myeloblastic leukemia from the lethal effects of cytosine arabinoside.'?,"No, the statement does not provide indirect support for the phrase ""Prednisolone related to seasonal allergic rhinitis."" The two statements discuss different topics: one is about hydrocortisone protecting blast cells in acute myeloblastic leukemia from cytosine arabinoside, while the other is about prednisolone being related to seasonal allergic rhinitis. + In conclusion, while prednisolone may cause cataracts as a side effect (as supported by other studies), the statement provided does not offer any indirect support for such an assertion due to its lack of relevance" +8757881,Prednisolone causes systemic lupus erythematosus,294,Fetal adrenocorticotropic hormone and cortisol increased to peak values within 2.8 hours of induced hypoxia but by 7.2 hours had begun to fall to values that were not significantly different from those at 1.4 hours.,False,"'Does the phrase ""Prednisolone causes systemic lupus erythematosus"" receive at least indirect support from the statement: ""Fetal adrenocorticotropic hormone and cortisol increased to peak values within 2.8 hours of induced hypoxia but by 7.2 hours had begun to fall to values that were not significantly different from those at 1.4 hours.""?","No, the statement does not provide indirect support for the phrase ""Prednisolone causes systemic lupus erythematosus"". The statement discusses fetal adrenocorticotropic hormone (ACTH) and cortisol levels in response to hypoxia, which is not directly related to Prednisolone or systemic lupus erythematosus (SLE). Prednisolone is a synthetic glucocorticoid often used in treating inflammatory diseases due to its immunosuppressive properties, while SLE is an autoimmune disease characterized by the production of autoantibodies leading to inflammation and tissue damage in multiple organs. Although glucocorticoids like Prednisolone can have various side effects, including increased susceptibility to infections, they do not cause SLE. - The connection between glucocorticoids like hydrocortisone and prednisolone is that they both belong to the same class of steroid hormones that have anti-inflammatory effects. However, the statement about hydrocortisone does not mention any relation to allergic rhinitis nor does it imply anything about prednisolone specifically. To establish indirect support, there should be some common ground between the two statements that can lead from one to the other logically; in this case, there is no such connection." -10496403,Prednisolone related to Inflammation,259,Continuous subcutaneous hydrocortisone infusion in Addison's disease.,False,Is the triple 'Prednisolone related to Inflammation' supported by the sentence: 'Continuous subcutaneous hydrocortisone infusion in Addison's disease.'?,"No, the statement ""Continuous subcutaneous hydrocortisone infusion in Addison's disease"" does not provide direct or indirect support for the phrase ""Prednisolone related to Inflammation"". + While it is true that excessive glucocorticoid levels can lead to Cushing's syndrome – characterized by redistribution of body fat, muscle weakness, mood changes, and other symptoms – it is distinct from SLE in both etiology and presentation. Therefore, without any direct link between Prednisolone use" +27658451,Prednisolone affects uveitis,295,Congenital adrenal hyperplasia (CAH) is a chronic condition and individuals are exposed to elevated androgen levels in utero as a result of the endogenous cortisol deficiency.,False,"'Does the phrase ""Prednisolone affects uveitis"" receive at least indirect support from the statement: ""Congenital adrenal hyperplasia (CAH) is a chronic condition and individuals are exposed to elevated androgen levels in utero as a result of the endogenous cortisol deficiency.""?","No, the statement does not provide indirect support for the phrase ""Prednisolone affects uveitis."" The connection between congenital adrenal hyperplasia (CAH), elevated androgen levels in utero due to endogenous cortisol deficiency, and prednisolone (a synthetic glucocorticoid used in treating inflammatory disorders) is tenuous at best without further information linking these concepts together. - The statement discusses the use of hydrocortisone in treating Addison's disease, which is a condition characterized by insufficient production of hormones by the adrenal glands. Hydrocortisone is a type of corticosteroid that can help replace missing hormones in Addison's disease but it is not synonymous with Prednisolone. + Prednisolone is known for its anti-inflammatory properties and could potentially be used in treating uveitis (inflammation of the uvea), but that is not explicitly stated in either statement provided. The statement about congenital adrenal hyperplasia (CAH) describes how affected individuals have elevated androgen levels due to cortisol deficiency but doesn't mention uveitis or any connection between uveitis and CAH or prednisolone. - Prednisolone is another type of corticosteroid often used for its potent anti-inflammatory effects. The connection between Prednisolone and inflammation is direct because Prednisolone works by reducing inflammation in the body. However, the statement provided does not mention Prednisolone or its effects on inflammation. Therefore, it does not support the claim that Prednisolone is related to inflammation." -10118116,Prednisolone related to Prednisone,260,The current findings underline the relevance of cortisol and DHEA assessments and the need for further scrutiny of their interplay to foster our understanding of the biological basis of stress regulation in BPD.,False,Is the triple 'Prednisolone related to Prednisone' supported by the sentence: 'The current findings underline the relevance of cortisol and DHEA assessments and the need for further scrutiny of their interplay to foster our understanding of the biological basis of stress regulation in BPD.'?,"No, the statement does not provide indirect support for the phrase ""Prednisolone related to Prednisone."" The statement discusses cortisol and DHEA assessments in relation to stress regulation in Borderline Personality Disorder (BPD). Prednisolone and Prednisone are both corticosteroids used in medical treatments but they are not directly related in this context. Therefore, the provided statement does not lend credence to the relationship between Prednisolone and Prednisone." -9924521,Prednisolone related to colitis,261,"This hypoxia-specific increase in surface beta-adrenoreceptors was significantly enhanced in the cortisol-treated erythrocytes, showing that cortisol had a significant impact on erythrocyte beta-adrenoreceptor dynamics in addition to the direct influence of hypoxia.",False,"Is the triple 'Prednisolone related to colitis' supported by the sentence: 'This hypoxia-specific increase in surface beta-adrenoreceptors was significantly enhanced in the cortisol-treated erythrocytes, showing that cortisol had a significant impact on erythrocyte beta-adrenoreceptor dynamics in addition to the direct influence of hypoxia.'?","No, the statement ""This hypoxia-specific increase in surface beta-adrenoreceptors was significantly enhanced in the cortisol-treated erythrocytes, showing that cortisol had a significant impact on erythrocyte beta-adrenoreceptor dynamics in addition to the direct influence of hypoxia"" does not provide indirect support for the phrase ""Prednisolone related to colitis."" + Thus, while prednisolone might affect uveitis in certain contexts (such as when used as an anti-inflammatory treatment), there is no clear basis for inferring that from the given statement about congenital adrenal" +27410586,Prednisolone affects castration-resistant prostate carcinoma,296,The results of our study confirm that thymol has strong ameliorative effect against hydrocortisone-induced oxidative stress injury in hepatic tissues.,False,"'Does the phrase ""Prednisolone affects castration-resistant prostate carcinoma"" receive at least indirect support from the statement: ""The results of our study confirm that thymol has strong ameliorative effect against hydrocortisone-induced oxidative stress injury in hepatic tissues.""?","No, the statement does not provide indirect support for the phrase ""Prednisolone affects castration-resistant prostate carcinoma"". - The statement discusses an experiment involving cortisol treatment on erythrocytes under hypoxic conditions and its effect on beta-adrenoreceptor dynamics. Prednisolone is a synthetic glucocorticoid often used in medical practice as an anti-inflammatory agent and shares structural similarities with cortisol; however, it is not identical to cortisol in terms of its physiological effects. + The statement discusses the ameliorative effect of thymol on hydrocortisone-induced oxidative stress injury in hepatic tissues. Prednisolone is a synthetic glucocorticoid often used in clinical settings for its anti-inflammatory and immunosuppressive effects, distinct from hydrocortisone, another glucocorticoid. - The provided evidence focuses on cortisol's impact on erythrocyte beta-adrenoreceptor dynamics under hypoxic conditions; it does not mention colitis nor any link between cortisol (or Prednisolone) and colitis. As colitis is not mentioned in the statement, there is" -9437304,Prednisolone related to systemic lupus erythematosus,262,"Congenital adrenal hyperplasia (CAH) due to deficiency of 21-hydroxylase is a disorder of the adrenal cortex characterised by cortisol deficiency, with or without aldosterone deficiency, and androgen excess.",False,"Is the triple 'Prednisolone related to systemic lupus erythematosus' supported by the sentence: 'Congenital adrenal hyperplasia (CAH) due to deficiency of 21-hydroxylase is a disorder of the adrenal cortex characterised by cortisol deficiency, with or without aldosterone deficiency, and androgen excess.'?","No, the statement does not provide indirect support for the phrase ""Prednisolone related to systemic lupus erythematosus"". The statement discusses congenital adrenal hyperplasia (CAH) due to deficiency of 21-hydroxylase, which is an entirely different medical condition from systemic lupus erythematosus (SLE). Prednisolone is a glucocorticoid often used in treating SLE due to its anti-inflammatory effects; however, CAH is not typically treated with Prednisolone but rather mineralocorticoids and glucocorticoids in general due to their ability to replace deficient cortisol. + While both prednisolone and hydrocortisone belong to the glucocorticoid class of steroid hormones, they have different clinical applications and effects on various tissues. The study does not mention prednisolone, castration-resistant prostate carcinoma, or any related disease models; therefore, it does not provide any indirect support for the stated phrase. - The two conditions have different etiologies as well; CAH is caused by genetic mutations leading to enzyme deficiencies in cortisol synthesis in contrast to SLE being an autoimmune condition where the immune system attacks healthy tissue in the body. Therefore, no meaningful connection can be drawn between Prednisolone usage in SLE treatment and CAH pathophysiology based on the provided statement alone." -9282196,Prednisolone related to IgA glomerulonephritis,263,"Changes of smoking behavior and serum adrenocorticotropic hormone, cortisol, prolactin, and endogenous opioids levels in nicotine dependence after naltrexone treatment.",False,"Is the triple 'Prednisolone related to IgA glomerulonephritis' supported by the sentence: 'Changes of smoking behavior and serum adrenocorticotropic hormone, cortisol, prolactin, and endogenous opioids levels in nicotine dependence after naltrexone treatment.'?","No, there is no direct or indirect support for the phrase ""Prednisolone related to IgA glomerulonephritis"" in the provided statement about changes in hormone levels after naltrexone treatment in nicotine dependence. This statement does not mention prednisolone, IgA glomerulonephritis, or any related concepts that would provide contextual support for the original phrase." -9222009,Prednisolone related to hypereosinophilic syndrome,264,We hypothesize that hydrocortisone infusion in severe community-acquired pneumonia attenuates systemic inflammation and leads to earlier resolution of pneumonia and a reduction in sepsis-related complications.,False,Is the triple 'Prednisolone related to hypereosinophilic syndrome' supported by the sentence: 'We hypothesize that hydrocortisone infusion in severe community-acquired pneumonia attenuates systemic inflammation and leads to earlier resolution of pneumonia and a reduction in sepsis-related complications.'?,"No, the statement does not provide direct or indirect support for the phrase ""Prednisolone related to hypereosinophilic syndrome"". The hypothesis presented in the statement is about hydrocortisone infusion in severe community-acquired pneumonia, its effects on systemic inflammation, and potential outcomes such as earlier resolution of pneumonia and reduction in sepsis-related complications. Prednisolone is a different glucocorticoid medication than hydrocortisone, and hypereosinophilic syndrome is a distinct medical condition characterized by high levels of eosinophils in the blood and tissues. Therefore, there is no clear connection between the two statements based on the information provided." -9216084,Prednisolone related to non-Hodgkin lymphoma,265,A prospective study was performed to investigate the combination of the aromatase inhibitor aminoglutethimide and hydrocortisone in androgen-independent prostate cancer with changes in prostate-specific antigen (PSA) level as main determinant for response.,False,Is the triple 'Prednisolone related to non-Hodgkin lymphoma' supported by the sentence: 'A prospective study was performed to investigate the combination of the aromatase inhibitor aminoglutethimide and hydrocortisone in androgen-independent prostate cancer with changes in prostate-specific antigen (PSA) level as main determinant for response.'?,"No, the statement does not provide indirect support for the phrase ""Prednisolone related to non-Hodgkin lymphoma."" The prospective study in question investigates the combination of aromatase inhibitor aminoglutethimide and hydrocortisone in treating androgen-independent prostate cancer. Prednisolone is not mentioned in the study, nor is there any connection made between the treatment regimen and non-Hodgkin lymphoma. Therefore, it is inappropriate to infer any relationship between Prednisolone and non-Hodgkin lymphoma based on this information alone." -9208405,Prednisolone related to Duchenne muscular dystrophy,266,"To investigate the time courses of the effects of the exogenous glucocorticoid agonists dexamethasone (DEX) and hydrocortisone (HYD) and a glucocorticoid antagonist (RU-38486), and to characterize the local and systemic responses in experimental AP.",False,"Is the triple 'Prednisolone related to Duchenne muscular dystrophy' supported by the sentence: 'To investigate the time courses of the effects of the exogenous glucocorticoid agonists dexamethasone (DEX) and hydrocortisone (HYD) and a glucocorticoid antagonist (RU-38486), and to characterize the local and systemic responses in experimental AP.'?","No, the statement does not provide indirect support for the phrase ""Prednisolone related to Duchenne muscular dystrophy."" The statement discusses an investigation into the effects of certain glucocorticoid agonists (dexamethasone and hydrocortisone) and an antagonist (RU-38486) in experimental acute pancreatitis (AP), but it does not mention Prednisolone nor Duchenne muscular dystrophy. Prednisolone is a synthetic glucocorticoid often used in treating various inflammatory diseases; however, without further evidence linking it specifically to Duchenne muscular dystrophy in this context, there is no basis for such a connection based on the provided statement alone." -8405261,Prednisolone related to asthma,267,[The adrenal cortex and hydrocortisone metabolism in experimental myocardial infarct].,False,Is the triple 'Prednisolone related to asthma' supported by the sentence: '[The adrenal cortex and hydrocortisone metabolism in experimental myocardial infarct].'?,"No, the statement ""The adrenal cortex and hydrocortisone metabolism in experimental myocardial infarct"" does not provide indirect support for the phrase ""Prednisolone related to asthma."" The statement discusses the adrenal cortex and hydrocortisone metabolism in the context of experimental myocardial infarct (heart attack). Prednisolone is a synthetic glucocorticoid often used for its anti-inflammatory effects in various conditions such as asthma; however, it is not mentioned nor implied in the provided statement. The two statements discuss different topics: one is about heart conditions, while the other is about asthma treatment, hence they do not lend support to each other." -7844202,Prednisolone related to chronic obstructive pulmonary disease,268,[Intraarticular hydrocortisone (cortril) in arthritis and osteoarthritis].,False,Is the triple 'Prednisolone related to chronic obstructive pulmonary disease' supported by the sentence: '[Intraarticular hydrocortisone (cortril) in arthritis and osteoarthritis].'?,"No, the statement does not provide indirect support for the phrase ""Prednisolone related to chronic obstructive pulmonary disease"" (COPD). The reason is that the statement refers specifically to intraarticular hydrocortisone (Cortril) usage in arthritis and osteoarthritis, which is different from prednisolone and has no direct relation to chronic obstructive pulmonary disease. + It is essential to maintain specificity when interpreting scientific statements, as extrapolations without proper evidence can lead to misinterpretations or inaccuracies in understanding biological phenomena and potential clinical applications." +27323391,Prednisolone affects focal segmental glomerulosclerosis,297,The effects of 8-bromo-cyclic AMP and cyclic AMP agonists (cholera toxin plus hydrocortisone and prostaglandin E2 plus 3-isobutyl-1-methylxanthine) on the cytotoxic activity of T cells generated during murine influenza virus infection have been examined.,False,"'Does the phrase ""Prednisolone affects focal segmental glomerulosclerosis"" receive at least indirect support from the statement: ""The effects of 8-bromo-cyclic AMP and cyclic AMP agonists (cholera toxin plus hydrocortisone and prostaglandin E2 plus 3-isobutyl-1-methylxanthine) on the cytotoxic activity of T cells generated during murine influenza virus infection have been examined.""?","No, the statement does not provide indirect support for the phrase ""Prednisolone affects focal segmental glomerulosclerosis."" The statement discusses the effects of certain agents on T cell cytotoxic activity during murine influenza virus infection in mice. Prednisolone is a corticosteroid used primarily for its anti-inflammatory and immunosuppressive effects in various conditions, such as asthma, allergies, and autoimmune diseases. Focal segmental glomerulosclerosis is a kidney disease characterized by scarring in specific areas of the kidney filtration units (glomeruli). Although both prednisolone and glomerulosclerosis involve the immune system, the statement provided does not offer any connection between prednisolone and focal segmental glomerulosclerosis." +27042309,Prednisolone affects pulmonary eosinophilia,298,Open oral provocation with 100 or 250 mg hydrocortisone in patients with hydrocortisone contact hypersensitivity elicited cutaneous reactions at sites of previous allergic dermatitis caused by hydrocortisone in two patients and at sites of earlier allergic patch test reactions caused by hydrocortisone in the other two patients.,False,"'Does the phrase ""Prednisolone affects pulmonary eosinophilia"" receive at least indirect support from the statement: ""Open oral provocation with 100 or 250 mg hydrocortisone in patients with hydrocortisone contact hypersensitivity elicited cutaneous reactions at sites of previous allergic dermatitis caused by hydrocortisone in two patients and at sites of earlier allergic patch test reactions caused by hydrocortisone in the other two patients.""?","No, the statement does not provide direct or indirect support for the phrase ""Prednisolone affects pulmonary eosinophilia."" - While prednisolone is also a corticosteroid like hydrocortisone, they have different therapeutic indications and administration routes. Prednisolone is more commonly used systemically for its anti-inflammatory effects in various conditions such as asthma, allergies, and autoimmune disorders. In contrast, intraarticular hydrocortisone is used primarily for local anti-inflammatory action in joint diseases like arthritis and osteoarthritis. + The statement discusses the effects of hydrocortisone on patients with hydrocortisone contact hypersensitivity, specifically in relation to cutaneous reactions at sites of previous allergic dermatitis or patch test reactions caused by hydrocortisone. This has no explicit or implicit connection to prednisolone or its effects on pulmonary eosinophilia. - In addition, chronic obstructive pulmonary disease is not typically treated with corticosteroids like prednisolone unless there is evidence of exacerbations or frequent symptoms, as long-term corticosteroid usage can" -7323744,Prednisolone related to pemphigus,269,[Use of cortisone and hydrocortisone in eye diseases].,False,Is the triple 'Prednisolone related to pemphigus' supported by the sentence: '[Use of cortisone and hydrocortisone in eye diseases].'?,"No, the statement ""Use of cortisone and hydrocortisone in eye diseases"" does not provide direct or indirect support for the phrase ""Prednisolone related to pemphigus."" Cortisone, hydrocortisone, and prednisolone belong to a class of drugs called corticosteroids, but they have different specific uses in medicine. Pemphigus is an autoimmune disorder that can be treated with corticosteroids like prednisolone; however, cortisone and hydrocortisone are not typically used for treating pemphigus due to their shorter duration of action compared to prednisolone. Therefore, while these drugs share some similarities in their pharmacological actions as corticosteroids, they have distinct applications in various medical contexts." -7262473,Prednisolone related to rheumatoid arthritis,270,[Topical use of hydrocortisone in otitis externa].,False,Is the triple 'Prednisolone related to rheumatoid arthritis' supported by the sentence: '[Topical use of hydrocortisone in otitis externa].'?,"No, the statement ""Topical use of hydrocortisone in otitis externa"" does not provide direct or indirect support for the phrase ""Prednisolone related to rheumatoid arthritis."" + Prednisolone is a synthetic glucocorticoid often used in clinical settings for its anti-inflammatory effects, which could potentially impact various cell types, including eosinophils. However, the statement provided does not offer any insights into this specific drug or its effects on eosinophils in the lungs or any other organ system. - + Therefore, it is crucial to evaluate each claim within its own context and not draw broad conclusions based on tenuous connections between disparate pieces of information." +25790510,Prednisolone affects allergic disease,299,"Although initial studies in transgenic mice and humans are encouraging, more data are required to conclusively prove the hypothesis that the adipose-tissue-specific overexpression of HSD1 and the resultant increase in tissue-specific cortisol concentrations result in human obesity, insulin resistance, high blood pressure, and metabolic syndrome.",False,"'Does the phrase ""Prednisolone affects allergic disease"" receive at least indirect support from the statement: ""Although initial studies in transgenic mice and humans are encouraging, more data are required to conclusively prove the hypothesis that the adipose-tissue-specific overexpression of HSD1 and the resultant increase in tissue-specific cortisol concentrations result in human obesity, insulin resistance, high blood pressure, and metabolic syndrome.""?","No, the statement does not provide indirect support for the phrase ""Prednisolone affects allergic disease."" The statement discusses research regarding adipose-tissue-specific overexpression of HSD1 (11β-hydroxysteroid dehydrogenase type 1) and its impact on obesity, insulin resistance, high blood pressure, and metabolic syndrome in humans and transgenic mice. While Prednisolone is a glucocorticoid that can modulate HSD1 activity, it is not explicitly mentioned in the statement in relation to allergic disease. Therefore, there is no implicit support for the connection between Prednisolone use and allergic disease in this context." +25165576,Prednisolone affects glomerulonephritis,300,"CONCLUSION: Although hydrocortisone has anti-inflammatory properties, it seems to provoke inflammation in the round window membrane after topical instillation.",False,"'Does the phrase ""Prednisolone affects glomerulonephritis"" receive at least indirect support from the statement: ""CONCLUSION: Although hydrocortisone has anti-inflammatory properties, it seems to provoke inflammation in the round window membrane after topical instillation.""?","No, the statement does not provide direct or indirect support for the phrase ""Prednisolone affects glomerulonephritis."" The conclusion in the statement refers specifically to hydrocortisone's effect on the round window membrane after topical instillation, not prednisolone or its effect on glomerulonephritis. Glomerulonephritis is a condition of the kidney, unrelated to the round window membrane in the ear where hydrocortisone was instilled in the study referenced. Prednisolone is a synthetic glucocorticoid like hydrocortisone but belongs to a different chemical class (prednisolone is a C1,1-β-hydroxylated derivative of prednisone) and may have different pharmacological properties and effects on various tissues compared to hydrocortisone. Therefore, inferences about prednisolone based on hydrocortisone studies should be made cautiously if at all." +24270725,Prednisolone affects dermatomyositis,301,"Type 2 glucocorticoid receptors (GRs), which are occupied by cortisol in humans in times of stress, are thought to be responsible for the glucocorticoid-induced memory impairment.",False,"'Does the phrase ""Prednisolone affects dermatomyositis"" receive at least indirect support from the statement: ""Type 2 glucocorticoid receptors (GRs), which are occupied by cortisol in humans in times of stress, are thought to be responsible for the glucocorticoid-induced memory impairment.""?","No, the statement does not provide indirect support for the phrase ""Prednisolone affects dermatomyositis."" The statement discusses type 2 glucocorticoid receptors (GRs) and their potential role in glucocorticoid-induced memory impairment. Prednisolone is a synthetic glucocorticoid used in various medical conditions, including dermatomyositis, but the statement does not make any connection between GRs, prednisolone, and dermatomyositis. Therefore, it is essential to evaluate each claim based on its specific context and evidence rather than making inferences without direct backing." +22922261,Prednisolone affects allergic bronchopulmonary aspergillosis,302,"Firstly, the GH-mediated increase in cortisol metabolism (mediated via reduced E to F conversion) may precipitate adrenal insufficiency in hypopituitary patients with partial adrenocorticotropic hormone deficiency commencing GH therapy.",False,"'Does the phrase ""Prednisolone affects allergic bronchopulmonary aspergillosis"" receive at least indirect support from the statement: ""Firstly, the GH-mediated increase in cortisol metabolism (mediated via reduced E to F conversion) may precipitate adrenal insufficiency in hypopituitary patients with partial adrenocorticotropic hormone deficiency commencing GH therapy.""?","No, the statement does not provide indirect support for the phrase ""Prednisolone affects allergic bronchopulmonary aspergillosis."" The statement discusses the effects of growth hormone (GH) therapy on cortisol metabolism in hypopituitary patients with partial adrenocorticotropic hormone deficiency, specifically addressing adrenal insufficiency as a potential risk. Prednisolone is not mentioned in this statement, nor is there any connection made between GH therapy, cortisol metabolism, and allergic bronchopulmonary aspergillosis. Prednisolone is a corticosteroid medication commonly used for treating various conditions such as allergies, asthma, and autoimmune disorders; however, its direct impact on allergic bronchopulmonary aspergillosis is not addressed in the provided statement." +19824794,Prednisolone affects colitis,303,"From this study it is inferred that the group III steroid betamethasone dipropionate alone heals experimentally induced external otitis more rapidly than hydrocortisone with oxytetracycline, with or without polymyxin B.",False,"'Does the phrase ""Prednisolone affects colitis"" receive at least indirect support from the statement: ""From this study it is inferred that the group III steroid betamethasone dipropionate alone heals experimentally induced external otitis more rapidly than hydrocortisone with oxytetracycline, with or without polymyxin B.""?","No, the statement does not provide indirect support for the phrase ""Prednisolone affects colitis."" The study referenced in the statement investigates the effects of different steroids on external otitis, not colitis. Prednisolone is not mentioned in the study at all, so there is no basis for inferring any effect of prednisolone on colitis from this statement. Colitis refers to inflammation of the colon, whereas otitis is inflammation of the ear. These two conditions affect different parts of the body and would require separate studies to determine any potential effects of various treatments." +19409335,Prednisolone affects sarcoidosis,304,"In conclusion, the reciprocal expression of CYP17 and the transcriptional repressors COUP-TF and DAX-1 indicates that these orphan receptors have a pathophysiologic role in the excessive hormone production in cortisol- and deoxycorticosterone-producing adrenocortical tumors.",False,"'Does the phrase ""Prednisolone affects sarcoidosis"" receive at least indirect support from the statement: ""In conclusion, the reciprocal expression of CYP17 and the transcriptional repressors COUP-TF and DAX-1 indicates that these orphan receptors have a pathophysiologic role in the excessive hormone production in cortisol- and deoxycorticosterone-producing adrenocortical tumors.""?","No, the statement does not provide indirect support for the phrase ""Prednisolone affects sarcoidosis."" The conclusion in the provided statement discusses the roles of CYP17, COUP-TF, and DAX-1 in cortisol- and deoxycorticosterone-producing adrenocortical tumors, but it does not mention sarcoidosis or Prednisolone. Prednisolone is a synthetic glucocorticoid used primarily for its anti-inflammatory effects in various conditions such as asthma, rheumatoid arthritis, and inflammatory bowel disease; it is not specifically indicated for sarcoidosis treatment unless there is concomitant inflammation. Sarcoidosis is a multisystem granulomatous disorder of unknown etiology characterized by noncaseating granulomas in involved organs; its pathophysiology is distinct from adrenocortical tumors. Therefore, further evidence would be needed to establish any connection between Prednisolone and sarcoidosis." +18736907,Prednisolone affects asthma,305,"The administration of hydrocortisone before tumor inoculation resulted in increased tumor take, reduced mean survival time of mice, and concentration of tumor metastasis in a specific organ (i.e., lung metastasis for Ehrlich hypotetraploid clone 1 tumor, and liver metastasis for Ehrlich hypotetraploid stock and Ehrlich hyperdiploid stock tumors).",False,"'Does the phrase ""Prednisolone affects asthma"" receive at least indirect support from the statement: ""The administration of hydrocortisone before tumor inoculation resulted in increased tumor take, reduced mean survival time of mice, and concentration of tumor metastasis in a specific organ (i.e., lung metastasis for Ehrlich hypotetraploid clone 1 tumor, and liver metastasis for Ehrlich hypotetraploid stock and Ehrlich hyperdiploid stock tumors).""?","No, the statement does not provide direct or indirect support for the phrase ""Prednisolone affects asthma."" The statement discusses the effects of hydrocortisone on tumor growth and metastasis in mice, which is not related to asthma in humans or animals. Prednisolone is a synthetic glucocorticoid similar to hydrocortisone but is not explicitly mentioned in the provided statement. Therefore, there is no connection between the two pieces of information in terms of their subject matter or implications." +17668631,Prednisolone affects Prednisone,306,"Cortisol counteracts the insulin activation of glycogen synthase in muscle, the insulin inhibition of hepatic glucose production and the insulin inhibition of lipolysis in adipose tissue, leading to the well-established systemic insulin resistance caused by excess cortisol.",True,"'Does the phrase ""Prednisolone affects Prednisone"" receive at least indirect support from the statement: ""Cortisol counteracts the insulin activation of glycogen synthase in muscle, the insulin inhibition of hepatic glucose production and the insulin inhibition of lipolysis in adipose tissue, leading to the well-established systemic insulin resistance caused by excess cortisol.""?","Yes, there is indirect support for the statement ""Prednisolone affects Prednisone"" from the provided statement about cortisol's effects on insulin resistance. This is because both Prednisolone and Prednisone belong to a class of drugs called glucocorticoids that have similar mechanisms of action in the body. - Hydrocortisone is a type of corticosteroid used topically for various inflammatory conditions such as otitis externa (ear infection). Prednisolone is also a corticosteroid but is often used systemically (orally) for conditions like rheumatoid arthritis due to its potent anti-inflammatory properties. + Glucocorticoids like cortisol, Prednisolone, and Prednisone can lead to insulin resistance by counteracting insulin activation of glycogen synthase in muscle, inhibiting hepatic glucose production, and inhibiting lipolysis in adipose tissue (as mentioned in the provided statement). Prednisolone and Prednisone specifically can bind to glucocorticoid receptors in cells leading to changes in gene expression that result in these metabolic effects. - + Therefore, if Prednisolone has these effects on insulin resistance due to its glucocorticoid activity, then it is reasonable to infer that Prednisone would have similar effects given that it is also a glucocorticoid drug. This inference is supported by studies showing that both Prednisol" +15888410,Prednisolone affects rheumatoid arthritis,307,"The amount of N-acetyl D-glucosamine in the zymogen granule membrane was not altered by caerulein acute pancreatitis induced under continuous hydrocortisone treatment, but it was decreased by the administration of L-364,718 over 7 days after pancreatitis induction.",False,"'Does the phrase ""Prednisolone affects rheumatoid arthritis"" receive at least indirect support from the statement: ""The amount of N-acetyl D-glucosamine in the zymogen granule membrane was not altered by caerulein acute pancreatitis induced under continuous hydrocortisone treatment, but it was decreased by the administration of L-364,718 over 7 days after pancreatitis induction.""?","No, the statement does not provide indirect support for the phrase ""Prednisolone affects rheumatoid arthritis"". The statement discusses the effects of caerulein acute pancreatitis induced under continuous hydrocortisone treatment on N-acetyl D-glucosamine in the zymogen granule membrane in rats. Hydrocortisone is a type of corticosteroid like prednisolone, but they have different mechanisms of action and uses in medicine. The study does not mention prednisolone nor rheumatoid arthritis; therefore, it does not provide any evidence that prednisolone affects rheumatoid arthritis. - Although both compounds belong to the same class (corticosteroids) and share some therapeutic effects (anti-inflammatory), they have different indications based on their specific pharmacological profiles. Therefore, the provided statement about hydrocortisone use in otitis externa does not lend any evidential support for prednisolone being related to rheumatoid arthritis. + The misconception might arise because both hydrocortisone and prednisolone belong to the same class of medications (corticosteroids). However, without specific evidence linking prednisolone to rheumatoid arthritis in the given statement, it cannot be used as indirect support for that claim. - + Rheumatoid arthritis is an autoimmune disorder primarily treated using disease-modifying antirhe" +13564625,Prednisolone affects asthma,308,False elevation of plasma cortisol in congenital adrenal hyperplasia.,False,"'Does the phrase ""Prednisolone affects asthma"" receive at least indirect support from the statement: ""False elevation of plasma cortisol in congenital adrenal hyperplasia.""?","No, the statement ""False elevation of plasma cortisol in congenital adrenal hyperplasia"" does not provide indirect support for the phrase ""Prednisolone affects asthma."" - Nonetheless, it is essential to acknowledge that corticosteroids can be used off-" -7206314,Prednisolone related to pulmonary tuberculosis,271,The use of hydrocortisone in ulcerative colitis: preliminary observations.,False,Is the triple 'Prednisolone related to pulmonary tuberculosis' supported by the sentence: 'The use of hydrocortisone in ulcerative colitis: preliminary observations.'?,"No, the statement ""The use of hydrocortisone in ulcerative colitis: preliminary observations"" does not provide direct or indirect support for the phrase ""Prednisolone related to pulmonary tuberculosis."" + Prednisolone is a synthetic glucocorticoid hormone that acts similarly to cortisol in the human body. It is often used as an anti-inflammatory agent in treating various conditions such as asthma, rheumatoid arthritis, and inflammatory bowel disease [1]. - + Congenital adrenal hyperplasia (CAH) is an inherited disorder of cortisol biosynthesis characterized by impaired cortisol production [2]. In some forms of CAH, there can be an overproduction of 17-hydroxyprogesterone, which is converted outside of the adrenal gland into cortisol precursors that can then be metabolized into androgens [3]. This results in false elevation of plasma cortisol levels due to these precursors being measured as cortisol [2]. - The statement discusses the use of hydrocortisone in treating ulcerative colitis, which is an inflammatory bowel disease. Hydrocortisone is a type of corticosteroid, similar to prednisolone, but they have different properties and uses in medicine. + Although both prednisolone and CA" +13234063,Prednisolone affects pericarditis,309,Further studies evaluating the mechanism of action and long term effects of hydrocortisone in cardiac arrest need to be conducted.,False,"'Does the phrase ""Prednisolone affects pericarditis"" receive at least indirect support from the statement: ""Further studies evaluating the mechanism of action and long term effects of hydrocortisone in cardiac arrest need to be conducted.""?","No, the statement does not provide indirect support for the phrase ""Prednisolone affects pericarditis."" The statement discusses further studies on hydrocortisone in cardiac arrest patients without mentioning prednisolone or pericarditis at all. Prednisolone is a glucocorticoid used for various inflammatory conditions; however, its specific effects on pericarditis have not been addressed in this statement. - + The two concepts - hydrocortisone in cardiac arrest patients and prednisolone in pericarditis - remain unconnected in terms of evidence provided in the statement. To establish indirect support for prednisolone affecting pericarditis from the given statement would require explicit or implicit connections between hydrocortisone, cardiac arrest patients, and pericarditis that do not exist in the provided context. - Although both hydrocortisone and prednisolone belong to the same class of drugs (corticosteroids), they have distinct clinical applications. The statement does not mention pulmonary tuberculosis nor prednisolone; therefore, it does not offer any support for the connection between prednisolone and pulmonary tuberculosis. + To further clarify the relationship between glucocorticoids (including prednisolone) and pericarditis, it would be essential to examine studies specifically investigating their use in treating pericarditis and their potential impact on its progression and resolution." +13029310,Prednisolone affects chronic obstructive pulmonary disease,310,"In acute MI, there were elevated plasma levels of cortisol depending on the MI severity with a small repeated peak of its increase on day 14 and its subsequent decrease, except deaths.",False,"'Does the phrase ""Prednisolone affects chronic obstructive pulmonary disease"" receive at least indirect support from the statement: ""In acute MI, there were elevated plasma levels of cortisol depending on the MI severity with a small repeated peak of its increase on day 14 and its subsequent decrease, except deaths.""?","No, the statement does not provide indirect support for the phrase ""Prednisolone affects chronic obstructive pulmonary disease"" (COPD). The statement discusses the relationship between acute myocardial infarction (MI) and cortisol levels, which is not directly related to Prednisolone or COPD. Prednisolone is a synthetic glucocorticoid used for its anti-inflammatory effects, while COPD is a chronic lung disease characterized by obstruction of lung airflow that interferes with normal breathing. Although both Prednisolone and cortisol (a natural glucocorticoid) have similar effects on inflammation, they are not identical substances, and one does not necessarily influence the other in a predictable manner in different disease contexts (MI vs COPD). A direct link or shared biological mechanism between MI-related cortisol changes and Prednisolone's impact on COPD needs further substantiation through specific studies or evidence connecting these entities." +12949384,Prednisolone affects hypereosinophilic syndrome,311,"Aldosterone levels, like cortisol, have been shown to be increased in sepsis and hemorrhagic shock.",False,"'Does the phrase ""Prednisolone affects hypereosinophilic syndrome"" receive at least indirect support from the statement: ""Aldosterone levels, like cortisol, have been shown to be increased in sepsis and hemorrhagic shock.""?","No, the statement does not provide indirect support for the phrase ""Prednisolone affects hypereosinophilic syndrome"". - + The statement discusses increased aldosterone levels in sepsis and hemorrhagic shock, which is not directly related to prednisolone or hypereosinophilic syndrome. Prednisolone is a synthetic glucocorticoid used in various clinical settings for its anti-inflammatory effects, while hypereosinophilic syndrome is a group of disorders characterized by persistent eosinophilia (high levels of eosinophils) that can lead to organ damage. + + Although prednisolone has been used off-label in treating hypereosinophilic syndrome due to its anti-inflammatory properties, there is no evidence in the statement provided that connects aldosterone levels in sepsis and hemorrhagic shock to prednisolone's impact on hypereosinophilic syndrome. - To establish a connection between prednisolone and pulmonary tuberculosis, one would need evidence from studies specifically investigating their relationship, such as those assessing prednisolone's impact on tuberculosis progress" -8856354,Prednisolone related to Prednisone,272,It can therefore be concluded that ointments containing either only E. coli BCS or a combination of BCS and hydrocortisone provide significant relief in perianal eczema as well as in early stages of hemorrhoidal disease.,False,Is the triple 'Prednisolone related to Prednisone' supported by the sentence: 'It can therefore be concluded that ointments containing either only E. coli BCS or a combination of BCS and hydrocortisone provide significant relief in perianal eczema as well as in early stages of hemorrhoidal disease.'?,"No, the statement does not provide indirect support for the phrase ""Prednisolone related to Prednisone"". The statement discusses the effectiveness of ointments containing Escherichia coli BCS (BCS) alone or in combination with hydrocortisone in treating perianal eczema and early stages of hemorrhoidal disease. Prednisolone and Prednisone are both corticosteroids but unrelated to E. coli BCS or hydrocortisone in this context. The provided statement does not mention these corticosteroids nor imply any connection between them." -26879702,Prednisolone has part acute lymphoblastic leukemia,273,The effect on cortisol supports the above conclusion and is consistent with HPA axis perturbation in opioid dependence as reported in other studies and extends these observations to stable methadone-maintained patients.,False,Is the triple 'Prednisolone has part acute lymphoblastic leukemia' supported by the sentence: 'The effect on cortisol supports the above conclusion and is consistent with HPA axis perturbation in opioid dependence as reported in other studies and extends these observations to stable methadone-maintained patients.'?,"No, the statement does not provide indirect support for the phrase ""Prednisolone has part acute lymphoblastic leukemia"". The statement discusses cortisol levels in opioid-dependent individuals who are on methadone maintenance therapy, which is not related to Prednisolone or acute lymphoblastic leukemia (ALL). Prednisolone is a synthetic glucocorticoid used for various medical purposes such as inflammation reduction but it is not known for its association with ALL. Thus, there is no connection between cortisol levels in opioid-dependent patients and Prednisolone-induced ALL mentioned in the statement." -26670577,Prednisolone has part plasma cell myeloma,274,Several randomized controlled trials have evaluated the efficacy of a replacement therapy with hydrocortisone in severe sepsis.,False,Is the triple 'Prednisolone has part plasma cell myeloma' supported by the sentence: 'Several randomized controlled trials have evaluated the efficacy of a replacement therapy with hydrocortisone in severe sepsis.'?,"No, the statement does not provide indirect support for ""Prednisolone has part plasma cell myeloma."" The two statements discuss different topics: one is about hydrocortisone replacement therapy in sepsis patients (a disease where immune function is often impaired), while the other makes an unrelated claim about prednisolone being part plasma cell mytesoma (a type of cancer). + To establish indirect support for ""Prednisolone affects hypereosinophilic syndrome"", one would need evidence linking prednisolone usage, e" +12057849,Prednisolone affects Crohn disease,312,"In this review, we summarize the effects of circadian melatonin, TSH, and cortisol on OA, focusing on how different levels of these hormones affect OA pathogenesis and recovery with respect to the circadian clock.",False,"'Does the phrase ""Prednisolone affects Crohn disease"" receive at least indirect support from the statement: ""In this review, we summarize the effects of circadian melatonin, TSH, and cortisol on OA, focusing on how different levels of these hormones affect OA pathogenesis and recovery with respect to the circadian clock.""?","No, the statement does not provide indirect support for the phrase ""Prednisolone affects Crohn disease."" The review focuses on the effects of circadian melatonin, TSH (thyroid-stimulating hormone), and cortisol on osteoarthritis (OA), not Crohn disease. Although cortisol is mentioned, it is in relation to its circadian rhythm rather than its therapeutic use as prednisolone in treating Crohn disease. Therefore, no inferences can be made about prednisolone's effect on Crohn disease based on this statement alone." +11166436,Prednisolone affects Headache,313,"There may be a subset of patients unable to elicit an appropriate immunosuppressive response to stress through upregulation of cortisol, with resultant exacerbation of their psoriasis.",False,"'Does the phrase ""Prednisolone affects Headache"" receive at least indirect support from the statement: ""There may be a subset of patients unable to elicit an appropriate immunosuppressive response to stress through upregulation of cortisol, with resultant exacerbation of their psoriasis.""?","No, the statement does not provide indirect support for the phrase ""Prednisolone affects Headache."" The statement discusses a potential relationship between stress-induced cortisol upregulation and psoriasis severity in certain patients, but it does not mention prednisolone or headaches. Prednisolone is a synthetic glucocorticoid used primarily for its anti-inflammatory effects, which may help manage psoriasis symptoms but does not have a direct impact on headaches. Therefore, there is no clear connection between the two statements in question." +11074135,Prednisolone affects lymphoma,314,"In addition to local effect, topical hydrocortisone therapy of childhood dermatitis is accompanied by a systemic effect that may be pronounced in the acute phase of disease.",False,"'Does the phrase ""Prednisolone affects lymphoma"" receive at least indirect support from the statement: ""In addition to local effect, topical hydrocortisone therapy of childhood dermatitis is accompanied by a systemic effect that may be pronounced in the acute phase of disease.""?","No, the statement does not provide direct or indirect support for the phrase ""Prednisolone affects lymphoma."" The statement discusses the systemic effects of topical hydrocortisone therapy in childhood dermatitis, but it does not mention Prednisolone nor lymphoma. Prednisolone is a synthetic glucocorticoid often used in systemic therapy for various conditions including lymphoma, but the statement does not provide any information about its effects on lymphoma. Therefore, it cannot be used as evidence to support the claim that Prednisolone affects lymphoma." +10651502,Prednisolone affects kidney disorder,315,"They answered the Fibromyalgia Impact Questionnaire (FIQ), Perceived Stress Questionnaire (PSQ) and McGill Pain Questionnaire (MPQ-Br), and collected saliva to evaluate CC before and after the end of each month.",False,"'Does the phrase ""Prednisolone affects kidney disorder"" receive at least indirect support from the statement: ""They answered the Fibromyalgia Impact Questionnaire (FIQ), Perceived Stress Questionnaire (PSQ) and McGill Pain Questionnaire (MPQ-Br), and collected saliva to evaluate CC before and after the end of each month.""?","No, the statement does not provide indirect support for the phrase ""Prednisolone affects kidney disorder."" The provided statement discusses participants answering questionnaires (FIQ, PSQ, MPQ-Br) and collecting saliva samples to evaluate cortisol concentration (CC) before and after each month. However, it does not mention Prednisolone use nor any kidney-related disorders. To establish a connection between Prednisolone usage and kidney disorders based on this information would require additional context and evidence linking these variables together." +10649036,Prednisolone affects chorioretinitis,316,"BACKGROUND: The hypothalamic-pituitary-adrenal stress axis plays a crucial role in community-acquired pneumonia (CAP), with high cortisol being associated with disease severity and corticosteroid treatment resulting in earlier time to recovery.",True,"'Does the phrase ""Prednisolone affects chorioretinitis"" receive at least indirect support from the statement: ""BACKGROUND: The hypothalamic-pituitary-adrenal stress axis plays a crucial role in community-acquired pneumonia (CAP), with high cortisol being associated with disease severity and corticosteroid treatment resulting in earlier time to recovery.""?","Yes, there is indirect support for the statement that prednisolone affects chorioretinitis based on the provided background information about community-acquired pneumonia (CAP). - Prednisolone is a synthetic glucocorticoid that has anti-inflammatory properties similar to hydrocortisone; however, neither statement provides any evidence linking these drugs to plasma cell myeloma. + The background statement suggests that corticosteroid treatment (which includes prednisolone) leads to earlier recovery in CAP patients who have higher cortisol levels associated with disease severity. - Furthermore, it is important to note that plasma cell myeloma is not composed ""of"" any drug; it is a malignant neoplasm characterized by proliferation of neoplastic plasma cells within bone marrow. Therefore, it is highly unlikely that any drug would be part of plasma cell myeloma." -18935086,Prednisolone coexists with Prednisone,275,[Diurnal variations in blood glucose and plasma cortisol in juvenile diabetes mellitus without ketoacidosis].,False,Is the triple 'Prednisolone coexists with Prednisone' supported by the sentence: '[Diurnal variations in blood glucose and plasma cortisol in juvenile diabetes mellitus without ketoacidosis].'?,"No, the statement does not provide indirect support for the phrase ""Prednisolone coexists with Prednisone."" The title refers to diurnal variations in blood glucose and plasma cortisol in juvenile diabetes mellitus without ketoacidosis. Prednisolone and Prednisone are both corticosteroids that can affect blood glucose levels; however, they are different medications that cannot ""coexist"" in a literal sense as they have similar but distinct chemical structures and uses in clinical settings. + Although chorioretinitis is not explicitly mentioned in the background statement, prednisolone is known for its anti-inflammatory effects due to its ability to inhibit phospholipase A2, which is involved in inflammatory processes (Calabrese et al., 2000). Chorioretinitis is an inflammatory condition affecting layers of the eye (choroid and retina). Therefore, it is plausible that prednisolone may have some effect on chorioretinitis due to its anti-inflammatory properties. - While both Prednisolone and Prednisone can increase blood glucose levels in patients due to their glucocorticoid activity, they have different pharmacokinetic profiles which means that they cannot be used simultaneously for therapeutic purposes as it would lead to unpredictable effects on plasma cortisol levels and overall patient response. + However, it is essential to acknowledge that direct evidence of prednisolone's effect on chorioretinitis is not present in the background statement. Further investigation would be required for more definitive conclusions about" +10555139,Prednisolone affects peptic ulcer disease,317,"The incidence of AF was compared among patients who received hydrocortisone, and the effect of low-dose hydrocortisone on AF was estimated using the inverse probability treatment weighting method based on propensity scores.",False,"'Does the phrase ""Prednisolone affects peptic ulcer disease"" receive at least indirect support from the statement: ""The incidence of AF was compared among patients who received hydrocortisone, and the effect of low-dose hydrocortisone on AF was estimated using the inverse probability treatment weighting method based on propensity scores.""?","No, the statement does not provide direct or indirect support for the phrase ""Prednisolone affects peptic ulcer disease."" The statement discusses a study comparing the incidence of atrial fibrillation (AF) between patients who received hydrocortisone, estimating the effect of low-dose hydrocortisone on AF using propensity scores. Prednisolone is not mentioned in the statement; therefore, it does not contribute any evidence regarding prednisolone's impact on peptic ulcer disease." +10183156,Prednisolone affects ulcerative colitis,318,"INTRODUCTION: Intrathecal administration of methotrexate, cytarabine, and hydrocortisone is commonly used to treat and prevent central nervous system involvement in leukemias and lymphomas.",False,"'Does the phrase ""Prednisolone affects ulcerative colitis"" receive at least indirect support from the statement: ""INTRODUCTION: Intrathecal administration of methotrexate, cytarabine, and hydrocortisone is commonly used to treat and prevent central nervous system involvement in leukemias and lymphomas.""?","No, the statement does not provide indirect support for the phrase ""Prednisolone affects ulcerative colitis."" The introduction mentions intrathecal administration of methotrexate, cytarabine, and hydrocortisone for treating central nervous system involvement in leukemias and lymphomas. Prednisolone is not mentioned in the statement; moreover, ulcerative colitis is not related to leukemias or lymphomas. Therefore, there is no connection between the two statements that would provide indirect support for ""Prednisolone affects ulcerative colitis.""" +9735520,Prednisolone affects Inflammation,319,"INTRODUCTION: Intrathecal administration of methotrexate, cytarabine, and hydrocortisone is commonly used to treat and prevent central nervous system involvement in leukemias and lymphomas.",True,"'Does the phrase ""Prednisolone affects Inflammation"" receive at least indirect support from the statement: ""INTRODUCTION: Intrathecal administration of methotrexate, cytarabine, and hydrocortisone is commonly used to treat and prevent central nervous system involvement in leukemias and lymphomas.""?","Yes, there is indirect support for the statement ""Prednisolone affects inflammation"" from the provided introduction. Prednisolone is a type of glucocorticoid, which is a class of steroid hormones known for their anti-inflammatory effects. The statement mentions hydrocortisone as one of the intrathecally administered drugs for treating leukemias and lymphomas, which is also a glucocorticoid like prednisolone. - Therefore, even though both drugs might have an indirect relationship through their shared impact on blood glucose and plasma cortisol levels in patients with juvenile diabetes mellitus, the statement does not offer any support for them ""coexisting"" together within an individual patient or context." -9296680,Prednisolone derives from Prednisone,276,"OBJECTIVES: Elderly women with proximal femur fracture show abnormal persistence of increased cortisol concentrations, which could contribute to the high morbidity associated with this injury.",False,"Is the triple 'Prednisolone derives from Prednisone' supported by the sentence: 'OBJECTIVES: Elderly women with proximal femur fracture show abnormal persistence of increased cortisol concentrations, which could contribute to the high morbidity associated with this injury.'?","No, the statement does not provide direct or indirect support for the phrase ""Prednisolone derives from Prednisone."" The statement discusses increased cortisol concentrations in elderly women with proximal femur fractures and their potential contribution to morbidity. + Glucocorticoids like prednisolone and hydrocortisone act on various cells within the immune system, reducing the production of chemicals that cause inflammation in response to infection or tissue damage. The use of hydrocortisone in treating central nervous system involvement in leukemias and lymphomas suggests that glucocorticoids play an essential role in managing inflammation associated with these conditions. - Prednisolone and Prednisone are both synthetic glucocorticoids used in treating various medical conditions such as inflammation, allergies, and autoimmune disorders. Prednisone is metabolized in the liver into Prednisolone, its active metabolite. However, there is no mention of either Prednisolone or Prednisone in the provided statement; therefore, it does not offer any support for the relationship between these two compounds." -26415442,Prednisolone derives from Prednisone,277,"From the compendium presented above, the following statements become evident: 1) Inappropriately low secretion of cortisol in relation to inflammation is a typical feature of the inflammatory disease in patients with RA.",False,"Is the triple 'Prednisolone derives from Prednisone' supported by the sentence: 'From the compendium presented above, the following statements become evident: 1) Inappropriately low secretion of cortisol in relation to inflammation is a typical feature of the inflammatory disease in patients with RA.'?","No, the statement does not provide any direct or indirect support for the phrase ""Prednisolone derives from Prednisone."" The statement discusses a feature of rheumatoid arthritis (RA) patients but does not make any connection between Prednisolone and Prednisone. + Therefore, while prednisolone is not explicitly mentioned in the statement, its classification as a glucocorticoid that shares anti-inflammatory properties with hydrocortisone provides indirect support for the claim that prednisolone affects" +9361682,Prednisolone affects osteoarthritis,320,"CONCLUSIONS: Early PN did not affect plasma concentrations of ACTH and (free) cortisol, but increased the incidence of septic shock, which statistically explained why more patients on early PN received corticosteroids.",False,"'Does the phrase ""Prednisolone affects osteoarthritis"" receive at least indirect support from the statement: ""CONCLUSIONS: Early PN did not affect plasma concentrations of ACTH and (free) cortisol, but increased the incidence of septic shock, which statistically explained why more patients on early PN received corticosteroids.""?","No, the statement does not provide indirect support for the phrase ""Prednisolone affects osteoarthritis."" The conclusion in the statement is about early parenteral nutrition (PN) affecting plasma concentrations of adrenocorticotropic hormone (ACTH) and cortisol, as well as its impact on septic shock incidence leading to more corticosteroid usage in patients on early PN. There is no mention of prednisolone or osteoarthritis in the provided statement. Prednisolone is a synthetic glucocorticoid used primarily for its anti-inflammatory effects in various conditions; it is not typically associated with osteoarthritis management." +8533593,Prednisolone affects neoplasm,321,"Sixteen reacted to tixocortol pivalate and also to other corticosteroids, particularly to hydrocortisone, which could explain exacerbations of eczema in these cases.",False,"'Does the phrase ""Prednisolone affects neoplasm"" receive at least indirect support from the statement: ""Sixteen reacted to tixocortol pivalate and also to other corticosteroids, particularly to hydrocortisone, which could explain exacerbations of eczema in these cases.""?","No, the statement does not provide indirect support for the phrase ""Prednisolone affects neoplasm."" - Prednisolone and Prednisone are both corticosteroids used in treating inflammation; however, they have different chemical structures due to variations in their side chains. Prednisone is metabolized into Prednisolone in the liver after absorption, but this is not implied in the statement provided. + The statement discusses patients who reacted to tixocortol pivalate and other corticosteroids, specifically mentioning hydrocortisone. It then suggests that these reactions could explain exacerbations of eczema in these cases. Prednisolone is a corticosteroid, but it is not specifically mentioned in the statement. - To establish whether Prednisolone derives from Prednisone based on available literature, one would need to look for evidence that demonstrates Prednisone metabolism into Prednisolone in vivo or in vitro studies, pharmacokinetic investigations, or other relevant experimental setups that demonstrate such a relationship between these two compounds explicitly." -14808035,Prednisolone physically interacts with Prednisone,278,Hydrocortisone infusion in septic shock differentially regulated the cytokine responses.,False,Is the triple 'Prednisolone physically interacts with Prednisone' supported by the sentence: 'Hydrocortisone infusion in septic shock differentially regulated the cytokine responses.'?,"No, the statement does not provide any direct or indirect support for the phrase ""Prednisolone physically interacts with Prednisone"". + Furthermore, while prednisolone does have immunosuppressive effects, which could potentially influence neoplasm growth, the statement does not provide any information linking prednisolone to neoplasm. Therefore, without specific evidence linking prednisolone to neoplasm, it is not accurate to infer that prednisolone affects neoplasm based on this statement alone." +7800426,Prednisolone affects acute lymphoblastic leukemia,322,"Finally, transient pre-treatment of healthy humans with cortisol induces a bi-phasic response during a later, delayed systemic inflammatory response: an intermediate cortisol concentration augments inflammation while a high cortisol concentration is neither pro- nor anti-inflammatory.",False,"'Does the phrase ""Prednisolone affects acute lymphoblastic leukemia"" receive at least indirect support from the statement: ""Finally, transient pre-treatment of healthy humans with cortisol induces a bi-phasic response during a later, delayed systemic inflammatory response: an intermediate cortisol concentration augments inflammation while a high cortisol concentration is neither pro- nor anti-inflammatory.""?","No, the statement does not provide direct support for the claim that prednisolone affects acute lymphoblastic leukemia (ALL). The statement discusses the effects of cortisol on inflammation in healthy humans, while the claim pertains to prednisolone's effect on ALL, which is a specific type of cancer. - The statement discusses Hydrocortisone infusion in septic shock and its effect on cytokine responses. Hydrocortisone, Prednisolone, and Prednisone are all glucocorticoids, but they are still different molecules with distinct chemical structures and properties. + Although both cortisol and prednisolone are glucocorticoids and share some biological activities, they have distinct pharmacological profiles and clinical uses. Prednisolone is often used in cancer treatment due to its immunosuppressive properties, but its specific effects on ALL may not be directly inferred from cortisol's influence on inflammation in healthy individuals. - The fact that one glucocorticoid (Hydrocortisone) interacts differently with certain biological processes (cytokine responses) in a specific context (septic shock) does not imply that another glucocorticoid (Prednisolone) physically interacts with a third glucocorticoid (Prednisone) in a general sense. + Nonetheless, understanding how cortisol affects inflammation could potentially provide insights into glucocorticoid pharmacology that might be relevant for prednisolone use in cancer treatment. However, further investigation and evidence specifically addressing prednisolone's effects on ALL would be required for stronger support of that claim." +7395227,Prednisolone affects systemic lupus erythematosus,323,"Adrenaline induces the early posthypoglycaemic insulin resistance, whereas cortisol and growth hormone are important for the insulin resistance that is observed later following hypoglycaemia.",False,"'Does the phrase ""Prednisolone affects systemic lupus erythematosus"" receive at least indirect support from the statement: ""Adrenaline induces the early posthypoglycaemic insulin resistance, whereas cortisol and growth hormone are important for the insulin resistance that is observed later following hypoglycaemia.""?","No, the statement does not provide indirect support for the phrase ""Prednisolone affects systemic lupus erythematosus"". - To establish whether Prednisolone physically interacts with Prednisone would require specific experimental evidence demonstrating such an interaction at the molecular level, which is not provided in the statement." -9296682,Prednisolone physically interacts with Prednisone,279,"BACKGROUND: There is substantial evidence of dysregulation of cortisol secretion, hippocampal abnormalities, and memory deficits in schizophrenia and other psychotic disorders.",False,"Is the triple 'Prednisolone physically interacts with Prednisone' supported by the sentence: 'BACKGROUND: There is substantial evidence of dysregulation of cortisol secretion, hippocampal abnormalities, and memory deficits in schizophrenia and other psychotic disorders.'?","No, the statement does not provide any direct or indirect support for the phrase ""Prednisolone physically interacts with Prednisone."" The background statement discusses dysregulation of cortisol secretion, hippocampal abnormalities, and memory deficits in schizophrenia and other psychotic disorders but does not mention Prednisolone or Prednisone nor imply any interaction between them. Prednisolone and Prednisone are both corticosteroids that can influence cortisol secretion but do not physically interact as they have similar chemical structures." -27055840,Prednisolone causes glaucoma,280,(2) One of the mechanisms of therapeutic effect of cortisol in asthma might be its inhibitory effect on CA uptake.,False,Is the triple 'Prednisolone causes glaucoma' supported by the sentence: '(2) One of the mechanisms of therapeutic effect of cortisol in asthma might be its inhibitory effect on CA uptake.'?,"No, the statement does not provide indirect support for the claim that ""Prednisolone causes glaucoma."" Prednisolone is a synthetic glucocorticoid often used in treating various conditions such as asthma due to its anti-inflammatory properties. The mechanism mentioned in the statement refers to cortisol (a natural glucocorticoid) inhibiting catecholamine (CA) uptake in asthma treatment. + The statement discusses the roles of adrenaline, cortisol, and growth hormone in insulin resistance following hypoglycaemia. Prednisolone is a synthetic glucocorticoid often used in the treatment of systemic lupus erythematosus (SLE), but it is not mentioned nor implied in the statement. - Although Prednisolone shares similarities in its mechanism of action with cortisol, it does not automatically imply that Prednisolone leads to glaucoma. Glaucoma is primarily associated with increased intraocular pressure (IOP), which is not explicitly mentioned in either statement. Therefore, further evidence is required to establish any connection between Prednisolone use and glaucoma risk." -26677891,Prednisolone causes uveitis,281,"OBJECTIVE: To compare cortisol levels, diurnal cycles of cortisol, and reactivity of cortisol to psychological stress in fibromyalgia (FM) and rheumatoid arthritis (RA) patients in their natural environment, and to examine the effect on results of accounting for differences among the groups in psychological stress and other lifestyle and psychosocial variables.",False,"Is the triple 'Prednisolone causes uveitis' supported by the sentence: 'OBJECTIVE: To compare cortisol levels, diurnal cycles of cortisol, and reactivity of cortisol to psychological stress in fibromyalgia (FM) and rheumatoid arthritis (RA) patients in their natural environment, and to examine the effect on results of accounting for differences among the groups in psychological stress and other lifestyle and psychosocial variables.'?","No, the statement does not provide indirect support for the phrase ""Prednisolone causes uveitis."" The objective in question pertains to a study comparing cortisol levels, diurnal cycles, and reactivity in fibromyalgia (FM) and rheumatoid arthritis (RA) patients in their natural environment while accounting for differences in psychological stress and other lifestyle variables. Prednisolone is not mentioned in this objective; therefore, it does not offer any support for the claim that Prednisolone causes uveitis. Uveitis is an inflammation of the uvea—the middle layer of the eye—whereas Prednisolone is a corticosteroid commonly used to treat inflammation in various conditions; however, it can have side effects that include increased susceptibility to infections and cataracts but not necessarily uveitis. + While cortisol is mentioned in the statement and is also a glucocorticoid like prednisolone, the statement does not make any connection between cortisol and SLE. Cortisol has immunosuppressive effects, which can be helpful in managing SLE, but the statement does not provide any evidence or implications regarding prednisolone's effect on SLE. - To further clarify, indirect support for ""Prednisolone causes uveitis"" would require evidence suggesting that Prednisolone increases the risk or likelihood of uveitis development in patients; it is not established by merely mentioning Prednisolone in the context of another study objective without any direct relation to uveitis" -25953223,Prednisolone causes kidney disorder,282,"OBJECTIVES: Recent data suggest that higher plasma cortisol may be associated with hypertension and insulin resistance in otherwise healthy men, as it is in Cushing's syndrome.",False,"Is the triple 'Prednisolone causes kidney disorder' supported by the sentence: 'OBJECTIVES: Recent data suggest that higher plasma cortisol may be associated with hypertension and insulin resistance in otherwise healthy men, as it is in Cushing's syndrome.'?","No, the statement does not provide indirect support for the phrase ""Prednisolone causes kidney disorder."" The objective provided in the statement discusses recent data suggesting an association between higher plasma cortisol levels and hypertension and insulin resistance in otherwise healthy men, similar to Cushing's syndrome. Prednisolone is a synthetic glucocorticoid that can increase cortisol levels in the body; however, it does not specifically mention any kidney disorders associated with Prednisolone use in the statement provided. Therefore, further evidence would be required to establish such a link between Prednisolone use and kidney disorders." -21556285,Prednisolone causes allergic disease,283,"These findings demonstrate 2 types of adrenal insufficiency with different clinical pictures: Type 1 is characterized by cortisol deficiency with hypoglycaemia, low corticoid levels and a low cortisol secretion rate; Type 2 shows aldosterone deficiency with prominent salt loss.",False,"Is the triple 'Prednisolone causes allergic disease' supported by the sentence: 'These findings demonstrate 2 types of adrenal insufficiency with different clinical pictures: Type 1 is characterized by cortisol deficiency with hypoglycaemia, low corticoid levels and a low cortisol secretion rate; Type 2 shows aldosterone deficiency with prominent salt loss.'?","No, the statement does not provide indirect support for the phrase ""Prednisolone causes allergic disease"". The statement discusses two types of adrenal insufficiency but does not mention or imply any connection to Prednisolone or allergic disease. Prednisolone is a synthetic glucocorticoid often used in treating various conditions such as inflammation, allergies, and autoimmune disorders by suppressing immune response; however, it does not inherently cause allergic disease. Misinterpretation could lead to incorrect conclusions about Prednisolone's effects and potential misuse of the medication in clinical settings." -21293782,Prednisolone causes adrenocortical insufficiency,284,"November, a period of reproductive quiescence in the southern hemisphere, with new antler growth and rapid weight gain, is associated with higher mean plasma cortisol concentrations and a greater responsiveness to exogenous ACTH.",False,"Is the triple 'Prednisolone causes adrenocortical insufficiency' supported by the sentence: 'November, a period of reproductive quiescence in the southern hemisphere, with new antler growth and rapid weight gain, is associated with higher mean plasma cortisol concentrations and a greater responsiveness to exogenous ACTH.'?","No, the statement does not provide indirect support for the phrase ""Prednisolone causes adrenocortical insufficiency."" + Therefore, without additional information linking prednisolone and SLE, the statement does not offer indirect support for the phrase ""Prednisolone affects systemic lupus erythematosus""." +21722189,Prednisolone affects Prednisone,324,"RESULTS: Within 24 hours following TBI, the concentrations of total cortisol, ACTH and gastrin increased proportionally to the severity of injury, especially significant in the experimental group (P less than 0.05).",False,"'Does the phrase ""Prednisolone affects Prednisone"" receive at least indirect support from the statement: ""RESULTS: Within 24 hours following TBI, the concentrations of total cortisol, ACTH and gastrin increased proportionally to the severity of injury, especially significant in the experimental group (P less than 0.05).""?","No, the statement does not provide any direct or indirect support for the phrase ""Prednisolone affects Prednisone."" The statement discusses the results of an experiment involving traumatic brain injury (TBI) and changes in concentrations of total cortisol, ACTH (adrenocorticotropic hormone), and gastrin in response to injury severity. However, it does not mention Prednisolone or Prednisone at all. - The statement discusses the relationship between reproductive quiescence in the southern hemisphere (November), higher mean plasma cortisol concentrations, and greater responsiveness to exogenous ACTH in animals during this period. Adrenocortical insufficiency refers to the inability of the adrenal glands to produce adequate amounts of steroid hormones such as cortisol and aldosterone in response to stress. Prednisolone is a synthetic glucocorticoid hormone that can suppress the natural production of cortisol in the body when administered at high doses for extended periods. + Prednisolone and Prednisone are both synthetic corticosteroids used in medical treatments for various conditions such as inflammation, allergies, and autoimmune disorders. While they have similar therapeutic effects due to their structural similarity, they have different pharmacokinetic properties; Prednisone is converted into Prednisolone in the body after absorption. - While both statements discuss cortisol hormones, they represent different contexts: one is related to natural physiological changes during reproductive quiescence in animals, while the other refers to adrenocortical insufficiency caused by exogenous glucocorticoid administration in medical settings. Therefore, there is no indirect support for the claim that Prednisolone causes" -20789636,Prednisolone causes ulcerative colitis,285,Cortisol metabolism in human obesity: impaired cortisone-->cortisol conversion in subjects with central adiposity.,False,Is the triple 'Prednisolone causes ulcerative colitis' supported by the sentence: 'Cortisol metabolism in human obesity: impaired cortisone-->cortisol conversion in subjects with central adiposity.'?,"No, the statement ""Cortisol metabolism in human obesity: impaired cortisone-->cortisol conversion in subjects with central adiposity"" does not provide indirect support for the claim that ""Prednisolone causes ulcerative colitis."" + Therefore, although both drugs may interact within the body due to their shared mechanism of action as glucocorticoids, evidence of one affecting the other would require specific experimental investigation into their interaction, which is not provided in the given statement. - Prednisolone is a synthetic glucocorticoid that is often used as an anti-inflammatory agent in treating various conditions, including ulcerative colitis. Cortisol is another glucocorticoid naturally produced in the human body by the adrenal glands in response to stress. The statement in question discusses an impairment in cortisone-to-cortisol conversion in obese individuals with central adiposity. + - Although both Prednisolone and cortisol have glucocorticoid activity, they have distinct mechanisms of action in vivo. Prednisolone is administered exogenously as a medication, while cortisol is endogenously produced in response to stress and other physiological signals. The study mentioned does not establish any direct link between Prednisolone use and ulcerative colitis development nor does it provide any evidence suggesting that" -17230021,Prednisolone causes Headache,286,The hypothalamic-pituitary-adrenal (HPA) axis is one of the key physiological systems that counterbalances this systemic inflammation through changes in adrenocorticotrophic hormone (ACTH) and cortisol.,False,Is the triple 'Prednisolone causes Headache' supported by the sentence: 'The hypothalamic-pituitary-adrenal (HPA) axis is one of the key physiological systems that counterbalances this systemic inflammation through changes in adrenocorticotrophic hormone (ACTH) and cortisol.'?,"No, the statement does not provide indirect support for ""Prednisolone causes Headache"". The connection between Prednisolone and headaches is not explicitly or implicitly mentioned in the provided information about the HPA axis, ACTH, cortisol, and systemic inflammation. + In summary, without any direct mention of Prednisolone" +9655099,Prednisolone has input Prednisone,325,NEW OR UNIQUE INFORMATION PROVIDED: This case is the first published report of hydrocortisone-responsive hypotension and transient CIRCI associated with naturally occurring septic shock in a dog.,False,"'Does the phrase ""Prednisolone has input Prednisone"" receive at least indirect support from the statement: ""NEW OR UNIQUE INFORMATION PROVIDED: This case is the first published report of hydrocortisone-responsive hypotension and transient CIRCI associated with naturally occurring septic shock in a dog.""?","No, the phrase ""Prednisolone has input Prednisone"" does not receive at least indirect support from the statement provided. - Prednisolone is a synthetic glucocorticoid often used for its potent anti-inflammatory effects, which can influence the HPA axis by suppressing cortisol production in the long term. Headaches can be associated with various factors such as changes in intracranial pressure, vascular dilation, or medication side effects like Prednisolone. However, without additional evidence linking Prednisolone use specifically to headaches through its interaction with the HPA axis or other mechanisms, it is not possible to infer support for that claim based on the given statement." -16304261,Prednisolone causes nephrotic syndrome,287,"The 5 dpf hypoxic exposure also elicited transient increases in whole body cortisol and in crf, uts1, and hsd20b2 expression, key regulators of the endocrine stress response.",False,"Is the triple 'Prednisolone causes nephrotic syndrome' supported by the sentence: 'The 5 dpf hypoxic exposure also elicited transient increases in whole body cortisol and in crf, uts1, and hsd20b2 expression, key regulators of the endocrine stress response.'?","No, the statement does not provide direct or indirect support for the claim that Prednisolone causes nephrotic syndrome. The provided statement discusses the effects of hypoxic exposure on zebrafish at 5 days post-fertilization (dpf), focusing on increases in cortisol levels and expression of certain regulators involved in the endocrine stress response (crf, uts1, hsd20b2). There is no mention of Prednisolone or nephrotic syndrome in the statement. Therefore, it is not possible to draw any conclusions about the relationship between Prednisolone and nephrotic syndrome based on this information alone." -15365269,Prednisolone causes infertility disorder,288,"At multiple regression analyses, HOMA-IR on admission in the IR group significantly correlated with thyroid-stimulating hormone, glucagon, and cortisol.",False,"Is the triple 'Prednisolone causes infertility disorder' supported by the sentence: 'At multiple regression analyses, HOMA-IR on admission in the IR group significantly correlated with thyroid-stimulating hormone, glucagon, and cortisol.'?","No, the statement does not provide indirect support for the phrase ""Prednisolone causes infertility disorder."" The provided statement discusses correlations between certain factors in patients who have insulin resistance (IR group), including HOMA-IR (Homeostatic Model Assessment for Insulin Resistance), thyroid-stimulating hormone (TSH), glucagon, and cortisol levels on admission. However, there is no mention of Prednisolone in the statement nor any information linking these factors to infertility disorders. + The statement discusses a case report of hydrocortisone-responsive hypotension and transient Critical Illness-Related Corticosteroid Insufficiency (CIRCI) associated with naturally occurring septic shock in a dog. It does not provide any information about Prednisolone or its relationship to Prednisone. - To provide indirect support for ""Prednisolone causes infertility disorder,"" there would need to be some evidence that Prednisolone affects fertility negatively in either humans or animal models. This evidence could be presented in various ways such as observing changes in hormone levels associated with fertility, reduced sperm count/motility in males, decreased ovarian function in females, or abnormalities in embryonic development during pregnancy. + Prednisolone and Prednisone are both corticosteroids used in veterinary medicine, but they have different pharmacokinetic profiles. Prednisone is a prodrug that is metabolized into Prednisolone in the liver. Therefore, while they are related, one cannot infer from the statement that Prednisolone has any direct input in Prednisone's function or vice versa. - In summary, while it is essential to evaluate each piece of evidence carefully when interpreting scientific statements, in this case, there is no connection between Prednisolone use and infertility disorders based on the provided" -14373522,Prednisolone causes exfoliative dermatitis,289,"The suppression of the anti-inflammatory effects of cortisol as a result of states of excessive stress leads to hypercatabolic diseases such as AIDS, sepsis and toxic shock syndrome and protein calorie malnutrition (NAIDS).",False,"Is the triple 'Prednisolone causes exfoliative dermatitis' supported by the sentence: 'The suppression of the anti-inflammatory effects of cortisol as a result of states of excessive stress leads to hypercatabolic diseases such as AIDS, sepsis and toxic shock syndrome and protein calorie malnutrition (NAIDS).'?","No, the statement does not provide indirect support for ""Prednisolone causes exfoliative dermatitis."" The statement discusses the suppression of anti-inflammatory effects of cortisol in relation to certain diseases but does not mention prednisolone or exfoliative dermatitis. Prednisolone is a synthetic glucocorticoid used for its anti-inflammatory effects in various medical conditions; however, its use can lead to side effects such as skin rashes, but not specifically exfoliative dermatitis. Therefore, while there is a connection between corticosteroids (including prednisolone) and skin issues, it does not provide support for the initial claim." -10735861,Prednisolone causes contact dermatitis,290,"The suppression of the anti-inflammatory effects of cortisol as a result of states of excessive stress leads to hypercatabolic diseases such as AIDS, sepsis and toxic shock syndrome and protein calorie malnutrition (NAIDS).",False,"Is the triple 'Prednisolone causes contact dermatitis' supported by the sentence: 'The suppression of the anti-inflammatory effects of cortisol as a result of states of excessive stress leads to hypercatabolic diseases such as AIDS, sepsis and toxic shock syndrome and protein calorie malnutrition (NAIDS).'?","No, the statement does not provide indirect support for the phrase ""Prednisolone causes contact dermatitis."" The statement discusses the suppression of anti-inflammatory effects of cortisol in states of excessive stress leading to certain diseases (NAIDS), but it does not mention Prednisolone or contact dermatitis at all. Prednisolone is a synthetic glucocorticoid used primarily for its anti-inflammatory properties in various medical conditions; contact dermatitis is an allergic skin reaction that may be caused by various substances but is not known to be caused by Prednisolone itself when used properly as prescribed by medical professionals." -10545904,Prednisolone causes pulmonary tuberculosis,291,"We report the case of a 41-year-old nonatopic women with a previous history of eczematous reaction due to hydrocortisone who suffered worsening of her perennial rhinitis in association with perinasal dermatitis from the use of budesonide in nasal spray form, and stomatitis and pharyngitis due to budesonide in a bronchial inhaler.",False,"Is the triple 'Prednisolone causes pulmonary tuberculosis' supported by the sentence: 'We report the case of a 41-year-old nonatopic women with a previous history of eczematous reaction due to hydrocortisone who suffered worsening of her perennial rhinitis in association with perinasal dermatitis from the use of budesonide in nasal spray form, and stomatitis and pharyngitis due to budesonide in a bronchial inhaler.'?","No, the statement does not provide indirect support for the claim that Prednisolone causes pulmonary tuberculosis. The statement reports an adverse reaction in a patient using budesonide, which is a type of corticosteroid used in treating allergies and inflammation, similar to prednisolone. However, it does not mention pulmonary tuberculosis nor any link between the patient's symptoms and prednisolone use. + It is crucial in scientific interpretation to stick closely to the evidence provided and not draw conclusions that go beyond the scope of the information given. This helps maintain the integrity of scientific discourse and prevents misinformation." +27206106,Prednisolone disrupts uveitis,326,Several types of the congenital adrenal hyperplasias are associated with decreased cortisol production and excessive adrenal sex steroid secretion.,False,"'Does the phrase ""Prednisolone disrupts uveitis"" receive at least indirect support from the statement: ""Several types of the congenital adrenal hyperplasias are associated with decreased cortisol production and excessive adrenal sex steroid secretion.""?","No, the statement does not provide direct or indirect support for the phrase ""Prednisolone disrupts uveitis."" - The symptoms mentioned in the statement could be associated with various conditions, including infections, allergies, or irritations caused by budesonide itself. Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis and is not known to be caused by prednisolone use. Prednisolone is a corticosteroid that can suppress the immune system, making individuals more susceptible to infections but not causing them directly. + Prednisolone is a synthetic glucocorticoid often used in medical treatments for its anti-inflammatory effects. Uveitis is an inflammation of the uvea, the middle layer of the eye. While it is plausible that Prednisolone could be used as a treatment for uveitis due to its anti-inflammatory properties, the statement provided does not mention Prednisolone, uveitis, or any direct link between cortisol production, adrenal sex steroid secretion, and uveitis disruption. - In conclusion, while the statement highlights an adverse reaction in a patient using budesonide, it does not provide any evidence supporting the claim that prednisolone causes pulmonary tuberculosis." -10519611,Prednisolone causes colitis,292,"In this perspective paper, we focus on the neuro-endocrine interactions that occur between progesterone, allopregnanolone, and cortisol during pregnancy, and propose that they align with our previously proposed model of FM pathogenesis based on GABAergic ""weakening"" in a thalamocortical neural loop system.",False,"Is the triple 'Prednisolone causes colitis' supported by the sentence: 'In this perspective paper, we focus on the neuro-endocrine interactions that occur between progesterone, allopregnanolone, and cortisol during pregnancy, and propose that they align with our previously proposed model of FM pathogenesis based on GABAergic ""weakening"" in a thalamocortical neural loop system.'?","No, the statement does not provide indirect support for the phrase ""Prednisolone causes colitis."" The focus of the perspective paper is on neuro-endocrine interactions between progesterone, allopregnanolone, and cortisol during pregnancy, which is unrelated to prednisolone or colitis. Therefore, there is no basis in this statement for suggesting that prednisolone causes colitis." -9464043,Prednisolone causes cataract,293,The present study reported a case of hydrocortisone-induced blood pressure reduction in a patient with anterior pituitary hypofunction due to allergic reaction.,False,Is the triple 'Prednisolone causes cataract' supported by the sentence: 'The present study reported a case of hydrocortisone-induced blood pressure reduction in a patient with anterior pituitary hypofunction due to allergic reaction.'?,"No, the statement does not provide indirect support for the claim that ""Prednisolone causes cataract."" The study mentioned in the statement investigates hydrocortisone-induced blood pressure reduction in a patient suffering from anterior pituitary hypofunction due to an allergic reaction. Prednisolone is structurally and functionally different from hydrocortisone; they belong to different classes of corticosteroids (glucocorticoids). Therefore, any potential ocular side effects observed in patients treated with hydrocortisone cannot be readily generalized to another corticosteroid like prednisolone without further evidence linking them together. + The statement discusses congenital adrenal hyperplasias (CAH), which are genetic disorders affecting cortisol production and adrenal sex steroid secretion due to enzyme deficiencies in cortisol synthesis pathways. However, there is no clear connection between these disorders and Prednisolone's impact on uveitis. - While both hydrocortisone and prednisolone have glucocorticoid activity and can cause side effects like cataracts, they differ in potency and duration of action. Hence, without concrete evidence specifically connecting prednisolone use to cataracts in patients, one cannot infer that prednisolone causes cataracts based on the given statement regarding hydrocortisone-induced blood pressure reduction in an allergic patient." -8757881,Prednisolone causes systemic lupus erythematosus,294,Fetal adrenocorticotropic hormone and cortisol increased to peak values within 2.8 hours of induced hypoxia but by 7.2 hours had begun to fall to values that were not significantly different from those at 1.4 hours.,False,Is the triple 'Prednisolone causes systemic lupus erythematosus' supported by the sentence: 'Fetal adrenocorticotropic hormone and cortisol increased to peak values within 2.8 hours of induced hypoxia but by 7.2 hours had begun to fall to values that were not significantly different from those at 1.4 hours.'?,"No, the statement does not provide indirect support for the phrase ""Prednisolone causes systemic lupus erythematosus."" The statement discusses fetal adrenocorticotropic hormone (ACTH) and cortisol levels in response to hypoxia, which is not directly related to Prednisolone or systemic lupus erythematosus (SLE). Prednisolone is a synthetic glucocorticoid used in various clinical settings for its potent anti-inflammatory effects while SLE is an autoimmune disease characterized by chronic inflammation due to loss of immune tolerance against self-antigens. While glucocorticoids like Prednisolone can have side effects including immune suppression, there is no direct causal relationship between Prednisolone use and development of SLE based on the provided information." -27658451,Prednisolone affects uveitis,295,Congenital adrenal hyperplasia (CAH) is a chronic condition and individuals are exposed to elevated androgen levels in utero as a result of the endogenous cortisol deficiency.,False,Is the triple 'Prednisolone affects uveitis' supported by the sentence: 'Congenital adrenal hyperplasia (CAH) is a chronic condition and individuals are exposed to elevated androgen levels in utero as a result of the endogenous cortisol deficiency.'?,"No, the statement does not provide direct or indirect support for the phrase ""Prednisolone affects uveitis."" The statement discusses congenital adrenal hyperplasia (CAH), a chronic condition that results in elevated androgen levels in utero due to endogenous cortisol deficiency. While prednisolone is often used as a treatment for CAH in order to manage cortisol levels, there is no mention in the statement about uveitis (inflammation of the middle layer of the eye) being affected by prednisolone treatment in individuals with CAH or otherwise. + To establish indirect support at best, additional information would be needed that associates CAH-related conditions (" +26515767,Prednisolone disrupts neoplasm,327,[Use of cryo-apheresis in the treatment of patients with cortisol-dependent bronchial asthma].,False,"'Does the phrase ""Prednisolone disrupts neoplasm"" receive at least indirect support from the statement: ""[Use of cryo-apheresis in the treatment of patients with cortisol-dependent bronchial asthma].""?","No, the statement does not provide indirect support for the phrase ""Prednisolone disrupts neoplasm."" - To provide indirect support for ""Prednisolone affects uveitis,"" there would need to be some link between CAH, prednisolone treatment, and uveitis in the statement. However, there is no such link provided in the statement given; therefore, it does not offer any support for the claim that prednisolone affects uveitis." -27410586,Prednisolone affects castration-resistant prostate carcinoma,296,The results of our study confirm that thymol has strong ameliorative effect against hydrocortisone-induced oxidative stress injury in hepatic tissues.,False,Is the triple 'Prednisolone affects castration-resistant prostate carcinoma' supported by the sentence: 'The results of our study confirm that thymol has strong ameliorative effect against hydrocortisone-induced oxidative stress injury in hepatic tissues.'?,"No, the statement does not provide indirect support for the phrase ""Prednisolone affects castration-resistant prostate carcinoma"". The study in question investigates the effects of thymol on hydrocortisone-induced oxidative stress injury in hepatic tissues, which is unrelated to prednisolone's potential impact on castration-resistant prostate carcinoma. Prednisolone is a synthetic glucocorticoid used primarily for its anti-inflammatory properties; it is not mentioned in the provided statement. Thus, there is no connection between thymol and prednisolone in terms of their respective effects on different biological systems. + The statement discusses the use of cryo-apheresis in treating patients with cortisol-dependent bronchial asthma, which is unrelated to Prednisolone disrupting neoplasm (abnormal tissue growth indicative of cancer). Cryo-apheresis is a medical procedure that removes blood from a patient, cools it for separation of plasma, then reinfuses the patient's blood back into their system after adding replacement plasma or cryoprecipitate. It is commonly used for various conditions such as hyperviscosity syndrome or leukocytosis (high white blood cell count) due to leukemia or severe infections. - However, it is important to note that both prednisolone and hydrocortisone belong to the glucocorticoid class of steroid hormones; therefore, they might share some mechanisms related to their pharmacological activities in certain contexts. Nonetheless, without explicit evidence linking prednisolone to castration-resistant prostate carcinoma in conjunction with thymol or hydrocortisone-induced oxidative stress injury in hepatic t" -27323391,Prednisolone affects focal segmental glomerulosclerosis,297,The effects of 8-bromo-cyclic AMP and cyclic AMP agonists (cholera toxin plus hydrocortisone and prostaglandin E2 plus 3-isobutyl-1-methylxanthine) on the cytotoxic activity of T cells generated during murine influenza virus infection have been examined.,False,Is the triple 'Prednisolone affects focal segmental glomerulosclerosis' supported by the sentence: 'The effects of 8-bromo-cyclic AMP and cyclic AMP agonists (cholera toxin plus hydrocortisone and prostaglandin E2 plus 3-isobutyl-1-methylxanthine) on the cytotoxic activity of T cells generated during murine influenza virus infection have been examined.'?,"No, the statement does not provide indirect support for the phrase ""Prednisolone affects focal segmental glomerulosclerosis."" The statement discusses the effects of certain substances on T cell cytotoxic activity during murine influenza virus infection in mice, which is unrelated to Prednisolone and focal segmental glomerulosclerosis in humans. Prednisolone is a synthetic glucocorticoid used primarily for its anti-inflammatory effects in various disease states, while focal segmental glomerulosclerosis is a kidney disease characterized by scarring in specific areas of the kidney glomeruli. The connection between these two concepts is not established in the provided statement." -27042309,Prednisolone affects pulmonary eosinophilia,298,Open oral provocation with 100 or 250 mg hydrocortisone in patients with hydrocortisone contact hypersensitivity elicited cutaneous reactions at sites of previous allergic dermatitis caused by hydrocortisone in two patients and at sites of earlier allergic patch test reactions caused by hydrocortisone in the other two patients.,False,Is the triple 'Prednisolone affects pulmonary eosinophilia' supported by the sentence: 'Open oral provocation with 100 or 250 mg hydrocortisone in patients with hydrocortisone contact hypersensitivity elicited cutaneous reactions at sites of previous allergic dermatitis caused by hydrocortisone in two patients and at sites of earlier allergic patch test reactions caused by hydrocortisone in the other two patients.'?,"No, the statement does not provide direct or indirect support for the phrase ""Prednisolone affects pulmonary eosinophilia."" The statement discusses the effects of hydrocortisone on patients with hydrocortisone contact hypersensitivity, while prednisolone is a different glucocorticoid medication that may have distinct effects on various biological processes and organ systems such as pulmonary eosinophilia in different contexts. + Prednisolone is a synthetic glucocorticoid used primarily for its anti-inflammatory effects in treating several conditions such as asthma, rheumatoid arthritis, severe allergies, and some skin disorders. While glucocorticoids like Prednisolone can impact cell growth and proliferation, there is no direct link established in this statement between Pred" +26379811,Prednisolone disrupts contact dermatitis,328,Hypotension after recruitment was reduced by HC (0 vs. 30%).,False,"'Does the phrase ""Prednisolone disrupts contact dermatitis"" receive at least indirect support from the statement: ""Hypotension after recruitment was reduced by HC (0 vs. 30%).""?","No, the statement ""Hypotension after recruitment was reduced by HC (0 vs. 30%)"" does not provide indirect support for the phrase ""Prednisolone disrupts contact dermatitis"". - To establish support for ""Prednisolone affects pulmonary eosinophilia,"" evidence should be provided that demonstrates prednisolone's impact on eosinophilia in the pulmonary system specifically. In order for evidence about hydrocortisone to be relevant, it would need to show a clear connection between hydrocortisone and prednisolone in terms of their mechanisms, pharmacodynamics, or therapeutic effects on pulmonary eosinophilia. This connection is not apparent in the provided statement." -25790510,Prednisolone affects allergic disease,299,"Although initial studies in transgenic mice and humans are encouraging, more data are required to conclusively prove the hypothesis that the adipose-tissue-specific overexpression of HSD1 and the resultant increase in tissue-specific cortisol concentrations result in human obesity, insulin resistance, high blood pressure, and metabolic syndrome.",False,"Is the triple 'Prednisolone affects allergic disease' supported by the sentence: 'Although initial studies in transgenic mice and humans are encouraging, more data are required to conclusively prove the hypothesis that the adipose-tissue-specific overexpression of HSD1 and the resultant increase in tissue-specific cortisol concentrations result in human obesity, insulin resistance, high blood pressure, and metabolic syndrome.'?","No, the statement does not provide indirect support for the phrase ""Prednisolone affects allergic disease."" The statement discusses research on transgenic mice and humans regarding adipose-tissue-specific overexpression of HSD1 (11β-hydroxysteroid dehydrogenase type 1) and its impact on obesity, insulin resistance, high blood pressure, and metabolic syndrome. Prednisolone is a synthetic glucocorticoid used primarily for its potent anti-inflammatory effects in treating various conditions such as allergies; however, it is not mentioned nor implied in the statement provided. + The statement in question pertains to the effect of HC (presumably Hydrocortisone) on hypotension after recruitment, which is not related to Prednisolone or contact dermatitis. Prednisolone is a synthetic glucocorticoid often used in dermatology for its anti-inflammatory effects, but its impact on contact dermatitis is not addressed in this statement. Therefore, no inferences can be made about Prednisolone's effect on contact dermatitis based on this information alone." +25763558,Prednisolone disrupts pneumonia,329,Fetal plasma cortisol concentrations were increased ( P < 0.05) during all levels of hypoxia.,False,"'Does the phrase ""Prednisolone disrupts pneumonia"" receive at least indirect support from the statement: ""Fetal plasma cortisol concentrations were increased ( P < 0.05) during all levels of hypoxia.""?","No, the statement does not provide indirect support for the phrase ""Prednisolone disrupts pneumonia."" - The two concepts—the effects of HSD1 overexpression on metabolic parameters and Prednisolone's impact on allergic disease—are distinct topics that require separate lines of evidence for support. Therefore, it is essential to evaluate each claim independently based on relevant and specific evidence related to each case." -25165576,Prednisolone affects glomerulonephritis,300,"CONCLUSION: Although hydrocortisone has anti-inflammatory properties, it seems to provoke inflammation in the round window membrane after topical instillation.",False,"Is the triple 'Prednisolone affects glomerulonephritis' supported by the sentence: 'CONCLUSION: Although hydrocortisone has anti-inflammatory properties, it seems to provoke inflammation in the round window membrane after topical instillation.'?","No, the statement does not provide indirect support for the phrase ""Prednisolone affects glomerulonephritis."" The conclusion in the statement discusses hydrocortisone's effect on the round window membrane after topical instillation, which is different from prednisolone and glomerulonephritis. Glomerulonephritis is a kidney disorder while the round window membrane is part of the inner ear anatomy; therefore, these conditions and treatments are not related. Prednisolone is a synthetic glucocorticoid like hydrocortisone but they have different therapeutic indications based on their specific properties. The provided statement does not contain any information linking prednisolone to glomerulonephritis; hence it does not offer any indirect support for that claim." -24270725,Prednisolone affects dermatomyositis,301,"Type 2 glucocorticoid receptors (GRs), which are occupied by cortisol in humans in times of stress, are thought to be responsible for the glucocorticoid-induced memory impairment.",False,"Is the triple 'Prednisolone affects dermatomyositis' supported by the sentence: 'Type 2 glucocorticoid receptors (GRs), which are occupied by cortisol in humans in times of stress, are thought to be responsible for the glucocorticoid-induced memory impairment.'?","No, the statement does not provide indirect support for the phrase ""Prednisolone affects dermatomyositis."" The statement discusses type 2 glucocorticoid receptors (GRs) and their role in glucocorticoid-induced memory impairment in humans during times of stress. Prednisolone is a synthetic glucocorticoid used in various medical conditions including dermatomyositis; however, the statement does not connect GRs in stress response with dermatomyositis or any therapeutic effect of prednisolone on it. + Prednisolone is a synthetic glucocorticoid often used in clinical settings to reduce inflammation. The statement given discusses an increase in fetal plasma cortisol concentrations during hypoxia, which is relevant because cortisol is a natural glucocorticoid hormone in humans and other animals. However, this does not establish a connection between Prednisolone and disruption of pneumonia. - To establish indirect support for ""Prednisolone affects dermatomyositis,"" additional information would be required that links GRs in dermatomyositis pathophysiology specifically, as well as prednisolone's action on these receptors in that context." -22922261,Prednisolone affects allergic bronchopulmonary aspergillosis,302,"Firstly, the GH-mediated increase in cortisol metabolism (mediated via reduced E to F conversion) may precipitate adrenal insufficiency in hypopituitary patients with partial adrenocorticotropic hormone deficiency commencing GH therapy.",False,"Is the triple 'Prednisolone affects allergic bronchopulmonary aspergillosis' supported by the sentence: 'Firstly, the GH-mediated increase in cortisol metabolism (mediated via reduced E to F conversion) may precipitate adrenal insufficiency in hypopituitary patients with partial adrenocorticotropic hormone deficiency commencing GH therapy.'?","No, the statement does not provide direct or indirect support for the phrase ""Prednisolone affects allergic bronchopulmonary aspergillosis."" The statement discusses the potential impact of growth hormone (GH) therapy on cortisol metabolism in hypopituitary patients, specifically those with partial adrenocorticotropic hormone deficiency. While prednisolone is a corticosteroid that can influence cortisol levels, the statement does not make any connection between prednisolone use and allergic bronchopulmonary aspergillosis (ABPA), which is an allergic reaction to the fungus Aspergillus that often affects individuals with cystic fibrosis or asthma. Therefore, further evidence would be required to establish a relationship between prednisolone use and ABPA." -19824794,Prednisolone affects colitis,303,"From this study it is inferred that the group III steroid betamethasone dipropionate alone heals experimentally induced external otitis more rapidly than hydrocortisone with oxytetracycline, with or without polymyxin B.",False,"Is the triple 'Prednisolone affects colitis' supported by the sentence: 'From this study it is inferred that the group III steroid betamethasone dipropionate alone heals experimentally induced external otitis more rapidly than hydrocortisone with oxytetracycline, with or without polymyxin B.'?","No, the statement does not provide direct or indirect support for the phrase ""Prednisolone affects colitis."" The study referenced in the statement investigates the effects of different steroids on external otitis, not colitis. Prednisolone is not mentioned in the statement, and even if it were, inference would still be needed to connect its impact on colitis due to the absence of explicit information about colitis in the statement." -19409335,Prednisolone affects sarcoidosis,304,"In conclusion, the reciprocal expression of CYP17 and the transcriptional repressors COUP-TF and DAX-1 indicates that these orphan receptors have a pathophysiologic role in the excessive hormone production in cortisol- and deoxycorticosterone-producing adrenocortical tumors.",False,"Is the triple 'Prednisolone affects sarcoidosis' supported by the sentence: 'In conclusion, the reciprocal expression of CYP17 and the transcriptional repressors COUP-TF and DAX-1 indicates that these orphan receptors have a pathophysiologic role in the excessive hormone production in cortisol- and deoxycorticosterone-producing adrenocortical tumors.'?","No, the statement does not provide direct or indirect support for the phrase ""Prednisolone affects sarcoidosis."" The conclusion in the statement is about the pathophysiologic role of CYP17 and transcriptional repressors COUP-TF and DAX-1 in cortisol- and deoxycorticosterone-producing adrenocortical tumors. Prednisolone is a synthetic glucocorticoid used primarily for its anti-inflammatory effects in various conditions such as asthma, rheumatoid arthritis, and COPD; it is not specifically mentioned in the context of sarcoidosis or adrenocortical tumors in this statement. + Pneumonia is an infection of the lungs that can be influenced by many factors, including immune response and inflammation. While Prednisolone could potentially impact pneumonia due to its anti-inflammatory properties, the statement provided does not offer any evidence or implications regarding Prednisolone's effect on pneumonia. - To establish whether prednisolone affects sarcoidosis, one would need evidence from studies that investigate prednisolone use in sarcoidosis patients specifically. This may include randomized controlled trials (RCTs), cohort studies, or case-control studies that demonstrate an association between prednisolone use and sarcoidosis outcomes. As it stands, there is no clear link between prednisolone and sarcoidosis based on" -18736907,Prednisolone affects asthma,305,"The administration of hydrocortisone before tumor inoculation resulted in increased tumor take, reduced mean survival time of mice, and concentration of tumor metastasis in a specific organ (i.e., lung metastasis for Ehrlich hypotetraploid clone 1 tumor, and liver metastasis for Ehrlich hypotetraploid stock and Ehrlich hyperdiploid stock tumors).",False,"Is the triple 'Prednisolone affects asthma' supported by the sentence: 'The administration of hydrocortisone before tumor inoculation resulted in increased tumor take, reduced mean survival time of mice, and concentration of tumor metastasis in a specific organ (i.e., lung metastasis for Ehrlich hypotetraploid clone 1 tumor, and liver metastasis for Ehrlich hypotetraploid stock and Ehrlich hyperdiploid stock tumors).'?","No, the statement does not provide indirect support for the phrase ""Prednisolone affects asthma."" The statement discusses an experiment involving hydrocortisone administration in mice with specific types of tumors, but it does not mention Prednisolone nor asthma at all. Prednisolone is a synthetic glucocorticoid used in various medical conditions like asthma but unrelated to tumor growth in mice from the provided statement. + Therefore, without additional information linking Prednisolone, its effects on inflammation or immune response, and pneumonia, it is not possible to infer that Prednisolone disrupts pneumonia based on the given statement." +25233555,Prednisolone disrupts allergic disease,330,"INTRA-CELL CORTISOL: Attention is also focused on the potential implication of cortisol in the genesis of metabolic syndrome, because cortisol is a potent antagonist of the effect of insulin and its presence in excess enhances visceral obesity and insulin resistance.",False,"'Does the phrase ""Prednisolone disrupts allergic disease"" receive at least indirect support from the statement: ""INTRA-CELL CORTISOL: Attention is also focused on the potential implication of cortisol in the genesis of metabolic syndrome, because cortisol is a potent antagonist of the effect of insulin and its presence in excess enhances visceral obesity and insulin resistance.""?","No, the statement does not provide direct or indirect support for the phrase ""Prednisolone disrupts allergic disease"". The provided statement discusses cortisol's potential role in metabolic syndrome, focusing on its antagonistic effect on insulin and its contribution to visceral obesity and insulin resistance. Prednisolone is a synthetic glucocorticoid often prescribed for its anti-inflammatory effects in various conditions, including allergic diseases; however, it is not directly linked to cortisol's antagonistic effect on insulin in this context. - To provide indirect support for ""Prednisolone affects asthma,"" there should be some connection between hydrocortisone/tumor growth in mice and Prednisolone/asthma in humans in terms of mechanism, shared biological pathways, or clinical relevance. In the absence of such connections, it is inappropriate to infer any relationship between Prednisolone and asthma based on the given statement alone." -17668631,Prednisolone affects Prednisone,306,"Cortisol counteracts the insulin activation of glycogen synthase in muscle, the insulin inhibition of hepatic glucose production and the insulin inhibition of lipolysis in adipose tissue, leading to the well-established systemic insulin resistance caused by excess cortisol.",False,"Is the triple 'Prednisolone affects Prednisone' supported by the sentence: 'Cortisol counteracts the insulin activation of glycogen synthase in muscle, the insulin inhibition of hepatic glucose production and the insulin inhibition of lipolysis in adipose tissue, leading to the well-established systemic insulin resistance caused by excess cortisol.'?","No, the statement does not provide indirect support for the phrase ""Prednisolone affects Prednisone."" + + Prednisolone's primary mechanism of action involves binding to glucocorticoid receptors in cells, thereby suppressing inflammation through various pathways that do not necessarily involve cortisol's impact on insulin sensitivity in metabolic syndrome. Although prednisolone can increase cortisol levels due to its interaction with the hypothalamic-pituitary-adrenal (HPA) axis, that specific aspect is not addressed in the statement provided, making it an indirect link at best. - The statement discusses the effects of cortisol on various metabolic processes in the body, specifically its impact on insulin resistance. Prednisolone and Prednisone are both synthetic glucocorticoids, which have similar effects on the body as cortisol due to their shared mechanism of action on glucocorticoid receptors. However, there is no mention in the statement about any interaction between Prednisolone and Prednisone themselves. Therefore, without further information about a direct or indirect relationship between these two drugs, we cannot infer that Prednisolone affects Prednisone based on this statement alone." -15888410,Prednisolone affects rheumatoid arthritis,307,"The amount of N-acetyl D-glucosamine in the zymogen granule membrane was not altered by caerulein acute pancreatitis induced under continuous hydrocortisone treatment, but it was decreased by the administration of L-364,718 over 7 days after pancreatitis induction.",False,"Is the triple 'Prednisolone affects rheumatoid arthritis' supported by the sentence: 'The amount of N-acetyl D-glucosamine in the zymogen granule membrane was not altered by caerulein acute pancreatitis induced under continuous hydrocortisone treatment, but it was decreased by the administration of L-364,718 over 7 days after pancreatitis induction.'?","No, the statement does not provide indirect support for the claim that ""Prednisolone affects rheumatoid arthritis."" The provided statement discusses changes in N-acetyl D-glucosamine levels in zymogen granule membranes under different conditions (continuous hydrocortisone treatment versus L-364,718 administration after pancreatitis induction). Rheumatoid arthritis is an autoimmune disorder, while caerulein acute pancreatitis is an inflammatory condition induced in animal models for experimental purposes. Prednisolone is indeed used in treating rheumatoid arthritis but addressing pancreatitis in an animal model does not provide evidence for its effectiveness in rheumatoid arthritis treatment. To provide indirect support for ""Prednisolone affects rheumatoid arthritis,"" there should be some connection between prednisolone, N-acetyl D-glucosamine levels (or zymogen granule membranes), and rheumatoid arthritis, which is absent in the given statement." -13564625,Prednisolone affects asthma,308,False elevation of plasma cortisol in congenital adrenal hyperplasia.,False,Is the triple 'Prednisolone affects asthma' supported by the sentence: 'False elevation of plasma cortisol in congenital adrenal hyperplasia.'?,"No, the statement ""False elevation of plasma cortisol in congenital adrenal hyperplasia"" does not provide direct or indirect support for the phrase ""Prednisolone affects asthma."" + + Therefore, further evidence would be required to" +14331279,Prednisolone disrupts hypereosinophilic syndrome,331,The effect of hydrocortisone on standardized skin-surface trauma.,False,"'Does the phrase ""Prednisolone disrupts hypereosinophilic syndrome"" receive at least indirect support from the statement: ""The effect of hydrocortisone on standardized skin-surface trauma.""?","No, the statement ""The effect of hydrocortisone on standardized skin-surface trauma"" does not provide indirect support for the phrase ""Prednisolone disrupts hypereosinophilic syndrome."" - Prednisolone is a synthetic glucocorticoid drug often used in treating asthma due to its anti-inflammatory properties. It works by mimicking the natural hormone cortisol produced by the adrenal glands. Congenital adrenal hyperplasia (CAH) is a genetic disorder affecting the adrenal glands' ability to produce hormones like cortisol and aldosterone. In some forms of CAH, there can be false elevations in plasma cortisol due to issues in hormone processing. + Hydrocortisone and Prednisolone are both corticosteroids used in treating various conditions, but they have different chemical structures and pharmacological properties that may lead to different therapeutic effects in specific contexts. Hypereosinophilic syndrome (HES) is characterized by an overproduction of eosinophils (a type of white blood cell) that can infiltrate various tissues and cause damage. Prednisolone has been used in treating HES due to its anti-inflammatory properties that can help reduce eosinophil levels. - While both prednisolone and CAH involve cortisol hormones, they represent different contexts. The statement about CAH does not provide insights into prednisolone's effects on asthma since it discusses a specific pathological condition affecting hormone regulation rather than addressing prednisolone as a therapeutic intervention for asthma symptoms. + On the other hand, hydrocortisone has been studied in relation to its effect on standardized skin-surface trauma; however, this does not inherently imply any effect on eosinophilic syndrome since skin-surface trauma is unrelated to eosinophil levels or function in the body. - To establish whether prednis" -13234063,Prednisolone affects pericarditis,309,Further studies evaluating the mechanism of action and long term effects of hydrocortisone in cardiac arrest need to be conducted.,False,Is the triple 'Prednisolone affects pericarditis' supported by the sentence: 'Further studies evaluating the mechanism of action and long term effects of hydrocortisone in cardiac arrest need to be conducted.'?,"No, the statement does not provide indirect support for the phrase ""Prednisolone affects pericarditis"". + While both hydrocortisone" +10594561,Prednisolone disrupts asthma,332,The action of hydrocortisone in synovial inflammation.,False,"'Does the phrase ""Prednisolone disrupts asthma"" receive at least indirect support from the statement: ""The action of hydrocortisone in synovial inflammation.""?","No, the statement ""The action of hydrocortisone in synovial inflammation"" does not provide indirect support for the phrase ""Prednisolone disrupts asthma."" - + Here's why: - The statement discusses further studies needed on hydrocortisone in cardiac arrest, which is different from prednisolone and pericarditis. Hydrocortisone is a type of corticosteroid often used in treating conditions like cardiac arrest, while prednisolone is another corticosteroid used for various inflammatory and immune system disorders. Pericarditis refers to inflammation in the pericardium, the lining around the heart. + Although both prednisolone and hydrocortisone are glucocorticoids, they have different specific indications and uses in clinical settings due to their unique pharmacokinetic and pharmacodynamic properties. Hydrocortisone is primarily used for its anti-inflammatory effects in conditions such as synovial inflammation (inflammation of the synovial membrane in joints), while prednisolone is often used in the treatment of various allergic and inflammatory conditions such as asthma due to its potent glucocorticoid activity. - + The statement ""The action of hydrocortisone in synovial inflammation"" implies that hydrocortisone has anti-inflammatory effects in joint-related inflammation but does not provide any information about prednisolone's effects on asthma pathophysiology. Therefore, it does not offer" +8854473,Prednisolone disrupts Inflammation,333,"The effects of stressful life events, coping, and cortisol on HIV infection.",True,"'Does the phrase ""Prednisolone disrupts Inflammation"" receive at least indirect support from the statement: ""The effects of stressful life events, coping, and cortisol on HIV infection.""?","Yes, there is indirect support for the phrase ""Prednisolone disrupts Inflammation"" from the statement ""The effects of stressful life events, coping, and cortisol on HIV infection."" - Although these elements belong to the same general class of medications (corticosteroids) and share some similar properties, they have distinct effects on different physiological processes. Therefore, evidence suggesting that hydrocortisone has certain effects in cardiac arrest does not necessarily imply that prednisolone will impact pericarditis in the same way. + Prednisolone is a synthetic glucocorticoid drug that is commonly used to reduce inflammation because it mimics the function of cortisol, a natural hormone produced by the adrenal gland in response to stress. Cortisol has a wide range of effects on various body systems, one of which is its anti-inflammatory effect. Prednisolone, therefore, can be said to disrupt inflammation by suppressing the immune system's response, which is often overactive in inflammatory conditions. - + The statement ""The effects of stressful life events, coping, and cortisol on HIV infection"" implies that cortisol has an impact on HIV infection, which is mediated through stressful life events and coping mechanisms. While this statement does not explicitly mention Prednisolone, it does suggest that cortisol can influence inflammation and immune function in HIV infection. Given that Prednisolone acts similarly" +27646185,Prednisolone prevents allergic disease,334,"Immunologic and hemodynamic effects of ""low-dose"" hydrocortisone in septic shock: a double-blind, randomized, placebo-controlled, crossover study.",False,"'Does the phrase ""Prednisolone prevents allergic disease"" receive at least indirect support from the statement: ""Immunologic and hemodynamic effects of ""low-dose"" hydrocortisone in septic shock: a double-blind, randomized, placebo-controlled, crossover study.""?","No, the statement does not provide indirect support for the phrase ""Prednisolone prevents allergic disease."" The study focuses on immunologic and hemodynamic effects of ""low-dose"" hydrocortisone in septic shock, which is not related to allergic disease or prednisolone use in preventing such conditions. Prednisolone is a synthetic glucocorticoid used primarily for its anti-inflammatory properties in various medical conditions including allergic reactions; however, its specific efficacy in preventing allergic disease is not discussed in the given study." +26227245,Prednisolone prevents synovitis,335,"To prolong the anti-tumor effect some mice were also given cyclophosphamide, hydrocortisone, or a second injection of virus.",False,"'Does the phrase ""Prednisolone prevents synovitis"" receive at least indirect support from the statement: ""To prolong the anti-tumor effect some mice were also given cyclophosphamide, hydrocortisone, or a second injection of virus.""?","No, the phrase ""Prednisolone prevents synovitis"" does not receive indirect support from the statement ""To prolong the anti-tumor effect some mice were also given cyclophosphamide, hydrocortisone, or a second injection of virus."" The statement does not provide any information about Prednisolone or its effects on synovitis. Hydrocortisone is a type of steroid like Prednisolone, but it is not necessarily indicative of Prednisolone's effects on synovitis. Therefore, more specific information is needed to provide indirect support for the initial claim." +19453072,Prednisolone prevents hypereosinophilic syndrome,336,"In conclusion, HRT in postmenopausal asthmatic women has a favorable influence on the course of asthma, reduces daily use of glucocorticosteroids and frequency of asthma exacerbations and normalizes serum concentrations of estradiol, cortisol and DHEAS, which were decreased before HRT.",False,"'Does the phrase ""Prednisolone prevents hypereosinophilic syndrome"" receive at least indirect support from the statement: ""In conclusion, HRT in postmenopausal asthmatic women has a favorable influence on the course of asthma, reduces daily use of glucocorticosteroids and frequency of asthma exacerbations and normalizes serum concentrations of estradiol, cortisol and DHEAS, which were decreased before HRT.""?","No, the statement does not provide indirect support for the phrase ""Prednisolone prevents hypereosinophilic syndrome"". The statement discusses hormone replacement therapy (HRT) in postmenopausal asthmatic women, its influence on asthma course, reduction of glucocorticosteroid use, frequency of asthma exacerbations, and normalization of serum concentrations of estradiol, cortisol, and DHEAS. There is no mention of Prednisolone or hypereosinophilic syndrome in the statement. Prednisolone is a synthetic glucocorticoid used for its anti-inflammatory effects in various conditions, while hypereosinophilic syndrome is a disorder characterized by an increased number of eosinophils in the blood and tissues, which can lead to inflammation and damage in various organs. The two concepts are unrelated in this context." +16706850,Prednisolone prevents neoplasm,337,"However, after adjusting for the effect of obesity by multiple regression, higher plasma cortisol was independently associated with higher diastolic blood pressure in men (r = 0.21, P = 0.04) but not in women, and higher fasting serum triglyceride levels in women (r = 0.28, P < 0. 001) but not in men.",False,"'Does the phrase ""Prednisolone prevents neoplasm"" receive at least indirect support from the statement: ""However, after adjusting for the effect of obesity by multiple regression, higher plasma cortisol was independently associated with higher diastolic blood pressure in men (r = 0.21, P = 0.04) but not in women, and higher fasting serum triglyceride levels in women (r = 0.28, P < 0. 001) but not in men.""?","No, the statement does not provide indirect support for the phrase ""Prednisolone prevents neoplasm."" + + The statement discusses the association of higher plasma cortisol levels with diastolic blood pressure in men and fasting serum triglyceride levels in women. It does not mention prednisolone or neoplasm (a type of abnormal tissue growth that can lead to cancer) at all. Prednisolone is a synthetic glucocorticoid hormone used for its anti-inflammatory effects and is sometimes used in cancer treatment, but this statement does not provide any information about its potential preventative effects against neoplasm. Therefore, it does not offer indirect support for the claim that prednisolone prevents neoplasm." +15809068,Prednisolone prevents colitis,338,"ii) Reduction of cortisone to cortisol in the liver may increase insulin resistance in type 2 diabetes mellitus, and inhibition of the enzyme may lead to a decrease in gluconeogenesis.",False,"'Does the phrase ""Prednisolone prevents colitis"" receive at least indirect support from the statement: ""ii) Reduction of cortisone to cortisol in the liver may increase insulin resistance in type 2 diabetes mellitus, and inhibition of the enzyme may lead to a decrease in gluconeogenesis.""?","No, the statement does not provide indirect support for the phrase ""Prednisolone prevents colitis."" The provided statement discusses the relationship between cortisone reduction, cortisol increase, insulin resistance in type 2 diabetes mellitus, and inhibition of enzymes leading to decreased gluconeogenesis. While prednisolone is a synthetic glucocorticoid that can act similarly to cortisol in the body, there is no direct link established between these concepts and colitis prevention. Prednisolone is sometimes used as a treatment for colitis due to its anti-inflammatory properties, but the statement does not provide any evidence or reasoning for its preventative effects against colitis." +11858005,Prednisolone prevents asthma,339,"Pretreatment of rats with hydrocortisone or protamin-Zn-insulin within 4 days altered in subsequent acute hypoxia (3 hrs, ""height"" 10 000 m) the isoenzyme spectrum of LDH in lungs, liver tissue and kidney cortex.",False,"'Does the phrase ""Prednisolone prevents asthma"" receive at least indirect support from the statement: ""Pretreatment of rats with hydrocortisone or protamin-Zn-insulin within 4 days altered in subsequent acute hypoxia (3 hrs, ""height"" 10 000 m) the isoenzyme spectrum of LDH in lungs, liver tissue and kidney cortex.""?","No, the statement does not provide indirect support for the phrase ""Prednisolone prevents asthma."" The statement discusses the effects of pretreatment of rats with hydrocortisone or protamin-Zn-insulin on the isoenzyme spectrum of LDH in lungs, liver tissue, and kidney cortex under acute hypoxia conditions. Prednisolone is neither mentioned nor implied in this statement. Furthermore, asthma is a complex chronic respiratory disease characterized by airway inflammation, bronchoconstriction, and hyperresponsiveness, which is not explicitly addressed in the provided statement." +10983909,Prednisolone prevents leprosy,340,Previously we related persistent cortisol increases to memory impairments in elderly humans studied over five years.,False,"'Does the phrase ""Prednisolone prevents leprosy"" receive at least indirect support from the statement: ""Previously we related persistent cortisol increases to memory impairments in elderly humans studied over five years.""?","No, the statement does not provide indirect support for the phrase ""Prednisolone prevents leprosy."" The initial statement is about cortisol increases being related to memory impairments in elderly humans over five years. Prednisolone is a synthetic glucocorticoid often used as an anti-inflammatory and immunosuppressant drug. While it is true that glucocorticoids like prednisolone can affect cortisol levels (since they mimic cortisol action), no direct link is established between prednisolone use and leprosy prevention in either statement. - To establish whether prednisolone affects pericarditis would require direct evidence linking prednisolone use with changes in pericarditis incidence, severity, or" -13029310,Prednisolone affects chronic obstructive pulmonary disease,310,"In acute MI, there were elevated plasma levels of cortisol depending on the MI severity with a small repeated peak of its increase on day 14 and its subsequent decrease, except deaths.",False,"Is the triple 'Prednisolone affects chronic obstructive pulmonary disease' supported by the sentence: 'In acute MI, there were elevated plasma levels of cortisol depending on the MI severity with a small repeated peak of its increase on day 14 and its subsequent decrease, except deaths.'?","No, the statement does not provide direct or indirect support for the phrase ""Prednisolone affects chronic obstructive pulmonary disease"" (COPD). The statement discusses the relationship between acute myocardial infarction (MI) severity and plasma cortisol levels but does not mention Prednisolone or COPD. Prednisolone is a synthetic glucocorticoid often used in treating inflammatory diseases such as COPD but is not mentioned in the provided statement. Therefore, no connection can be inferred between Prednisolone and COPD based on this statement alone." -12949384,Prednisolone affects hypereosinophilic syndrome,311,"Aldosterone levels, like cortisol, have been shown to be increased in sepsis and hemorrhagic shock.",False,"Is the triple 'Prednisolone affects hypereosinophilic syndrome' supported by the sentence: 'Aldosterone levels, like cortisol, have been shown to be increased in sepsis and hemorrhagic shock.'?","No, the statement does not provide indirect support for the phrase ""Prednisolone affects hypereosinophilic syndrome"". The relationship between aldosterone levels (a mineralocorticoid) and cortisol levels (a glucocorticoid), both being stress hormones affected by sepsis and hemorrhagic shock, is not directly related to Prednisolone, which is a synthetic glucocorticoid used primarily for its anti-inflammatory effects. Hypereosinophilic syndrome is characterized by an abnormal increase in eosinophils, a type of white blood cell. While glucocorticoids like Prednisolone can impact immune system functioning, there is no clear link provided between Prednisolone and hypereosinophilic syndrome based on these statements alone. + To further elaborate on why there is no indirect support for ""Prednisolone prevents leprosy,"" let us consider some aspects of leprosy and prednisolone use in treating it. Leprosy is an infectious disease caused by Mycobacterium leprae, which primarily affects the skin, peripheral nerves, mucosa of upper respiratory tract, and eyes. Prednisolone is sometimes used in treating leprosy due to its immunosuppressive properties; however, it is not used as a preventive measure against leprosy but rather" +10240036,Prednisolone prevents Inflammation,341,It was suggested that the progressive shift from type 1 to type 2 cytokine production characteristic of HIV infection could be at least partially provoked by the increase in the production of cortisol and the reduction of DHEA.,True,"'Does the phrase ""Prednisolone prevents Inflammation"" receive at least indirect support from the statement: ""It was suggested that the progressive shift from type 1 to type 2 cytokine production characteristic of HIV infection could be at least partially provoked by the increase in the production of cortisol and the reduction of DHEA.""?","Yes, there is indirect support for the claim that Prednisolone prevents inflammation based on the provided statement. Prednisolone is a synthetic glucocorticoid hormone similar to cortisol in function; it reduces inflammation by mimicking the action of hormones that the body naturally produces in response to stress such as cortisol. The statement suggests that an increase in cortisol production during HIV infection may contribute to a shift from type 1 (pro-inflammatory) to type 2 (anti-inflammatory) cytokine production. Consequently, administering exogenous glucocorticoids like Prednisolone could help counteract inflammation by further increasing cortisol-like activity in the body during HIV infection. - To establish indirect support for ""Prednisolone affects hypereosinophilic syndrome"", one would need evidence showing that Prednisolone influences eosinophil counts or activity in some way – either increasing, decreasing, or otherwise altering their behavior – which is not provided in the given statement about aldosterone and cortis" -12057849,Prednisolone affects Crohn disease,312,"In this review, we summarize the effects of circadian melatonin, TSH, and cortisol on OA, focusing on how different levels of these hormones affect OA pathogenesis and recovery with respect to the circadian clock.",False,"Is the triple 'Prednisolone affects Crohn disease' supported by the sentence: 'In this review, we summarize the effects of circadian melatonin, TSH, and cortisol on OA, focusing on how different levels of these hormones affect OA pathogenesis and recovery with respect to the circadian clock.'?","No, the statement does not provide direct or indirect support for the claim that ""Prednisolone affects Crohn disease."" The review focuses on summarizing the effects of circadian melatonin, TSH (thyroid-stimulating hormone), and cortisol on osteoarthritis (OA). There is no mention of Prednisolone, which is a synthetic glucocorticoid used primarily for its anti-inflammatory properties in various diseases such as Crohn disease. Therefore, it is not possible to draw any conclusions about Prednisolone's effects on Crohn disease based on this statement alone. + However, it is crucial to note that while Prednisolone may help manage inflammation in HIV patients, its long-term use may have detrimental side effects such as immunosuppression, which could negatively impact patients’ ability to fight off opportunistic infections associated with HIV. Therefore, careful consideration should be given when prescribing Prednisolone for inflammation in HIV patients, taking into" +18452194,Prednisolone exacerbates ulcerative colitis,342,CONCLUSIONS: This study suggests that 24 h urinary free cortisol could be considered as a potential index of adrenal cortisol production in patients with liver cirrhosis and it potentially detects patients with a high mortality risk.,False,"'Does the phrase ""Prednisolone exacerbates ulcerative colitis"" receive at least indirect support from the statement: ""CONCLUSIONS: This study suggests that 24 h urinary free cortisol could be considered as a potential index of adrenal cortisol production in patients with liver cirrhosis and it potentially detects patients with a high mortality risk.""?","No, the statement does not provide indirect support for the phrase ""Prednisolone exacerbates ulcerative colitis."" The conclusion is about using 24-hour urinary free cortisol as a potential index of adrenal cortisol production in patients with liver cirrhosis, which could potentially detect patients with a high mortality risk. Prednisolone is a synthetic glucocorticoid, structurally related to cortisol, but there is no mention of its impact on ulcerative colitis in this conclusion. Ulcerative colitis is also not mentioned in the conclusion at all. Therefore, it is not possible to infer any relationship between Prednisolone and ulcerative colitis exacerbation based on this statement alone." +25753407,Prednisolone predisposes neoplasm,343,Congenital adrenal hyperplasia (CAH) is an autosomal recessive disorder that leads to the partial or complete deficiency of cortisol and aldosterone production from the adrenal glands.,False,"'Does the phrase ""Prednisolone predisposes neoplasm"" receive at least indirect support from the statement: ""Congenital adrenal hyperplasia (CAH) is an autosomal recessive disorder that leads to the partial or complete deficiency of cortisol and aldosterone production from the adrenal glands.""?","No, the statement does not provide indirect support for the phrase ""Prednisolone predisposes neoplasm."" - However, it is important to note that cortisol is also a glucocorticoid like Prednisolone, so there might be some overlap in their mechanisms in terms of anti-inflammatory effects in certain conditions like Crohn disease. Nonetheless, more specific evidence is required to validate such connections between Prednisolone and Crohn disease." -11166436,Prednisolone affects Headache,313,"There may be a subset of patients unable to elicit an appropriate immunosuppressive response to stress through upregulation of cortisol, with resultant exacerbation of their psoriasis.",False,"Is the triple 'Prednisolone affects Headache' supported by the sentence: 'There may be a subset of patients unable to elicit an appropriate immunosuppressive response to stress through upregulation of cortisol, with resultant exacerbation of their psoriasis.'?","No, the statement does not provide direct or indirect support for the phrase ""Prednisolone affects Headache."" The statement discusses a potential subset of patients who cannot appropriately respond immunosuppressively to stress due to insufficient cortisol upregulation leading to psoriasis exacerbation. Prednisolone is a synthetic glucocorticoid used primarily for its potent anti-inflammatory effects in various conditions such as psoriasis; however, it does not mention any connection between Prednisolone use and headaches. + The statement discusses congenital adrenal hyperplasia (CAH), an autosomal recessive disorder that affects cortisol and aldosterone production in the adrenal glands due to genetic mutations. Prednisolone is a synthetic glucocorticoid often used in treating various conditions such as inflammation, allergies, and autoimmune disorders by mimicking cortisol's effects in the body. - Although stress and cortisol levels have been linked to migraines and headaches in some studies, there is no explicit information in the given statement that links Prednisolone use to headache relief or exacerbation. Furthermore, Prednisolone is known to have side effects that include headaches; however, this is not explicitly mentioned in the statement either. Therefore, it is not possible to infer any relationship between Prednisolone use and headaches based solely on the provided statement." -11074135,Prednisolone affects lymphoma,314,"In addition to local effect, topical hydrocortisone therapy of childhood dermatitis is accompanied by a systemic effect that may be pronounced in the acute phase of disease.",False,"Is the triple 'Prednisolone affects lymphoma' supported by the sentence: 'In addition to local effect, topical hydrocortisone therapy of childhood dermatitis is accompanied by a systemic effect that may be pronounced in the acute phase of disease.'?","No, the statement does not provide direct or indirect support for the phrase ""Prednisolone affects lymphoma"". The statement discusses the systemic effect of topical hydrocortisone therapy in childhood dermatitis, which is not related to lymphoma or Prednisolone. Prednisolone is a synthetic glucocorticoid often used in the treatment of various conditions including lymphoma, but the statement provided does not offer any information about Prednisolone's effect on lymphoma." -10651502,Prednisolone affects kidney disorder,315,"They answered the Fibromyalgia Impact Questionnaire (FIQ), Perceived Stress Questionnaire (PSQ) and McGill Pain Questionnaire (MPQ-Br), and collected saliva to evaluate CC before and after the end of each month.",False,"Is the triple 'Prednisolone affects kidney disorder' supported by the sentence: 'They answered the Fibromyalgia Impact Questionnaire (FIQ), Perceived Stress Questionnaire (PSQ) and McGill Pain Questionnaire (MPQ-Br), and collected saliva to evaluate CC before and after the end of each month.'?","No, the statement does not provide direct or indirect support for the phrase ""Prednisolone affects kidney disorder."" The provided information pertains to patients answering questionnaires about fibromyalgia impact, perceived stress, and pain; in addition to saliva collection for cortisol evaluation before and after each month. There is no mention of prednisolone use nor kidney disorder in the statement." -10649036,Prednisolone affects chorioretinitis,316,"BACKGROUND: The hypothalamic-pituitary-adrenal stress axis plays a crucial role in community-acquired pneumonia (CAP), with high cortisol being associated with disease severity and corticosteroid treatment resulting in earlier time to recovery.",True,"Is the triple 'Prednisolone affects chorioretinitis' supported by the sentence: 'BACKGROUND: The hypothalamic-pituitary-adrenal stress axis plays a crucial role in community-acquired pneumonia (CAP), with high cortisol being associated with disease severity and corticosteroid treatment resulting in earlier time to recovery.'?","Yes, indirect support can be inferred from the statement provided for the claim ""Prednisolone affects chorioretinitis"". This is because Prednisolone is a synthetic glucocorticoid that acts on the hypothalamic-pituitary-adrenal (HPA) axis which plays a crucial role in community-acquired pneumonia (CAP). The statement highlights that corticosteroid treatment (which includes Prednisolone) results in earlier time to recovery in CAP patients who have high cortisol levels associated with disease severity. + While both CAH and Prednisolone have connections to cortisol production, there is no mention of neoplasm (abnormal tissue growth that can lead to cancer) in either statement. Therefore, no indirect support can be inferred from the statement provided concerning Prednisolone predisposing neoplasm. + + However, it is essential to note that long-term glucocorticoid use like Prednisolone has potential side effects such as increased risk of infections, osteoporosis, diabetes, and adrenal suppression; there is no conclusive evidence linking Prednisol" +16546227,Prednisolone predisposes pneumonia,344,[Reaction of autogenous cortisol production in patients with extensive psoriasis vulgaris or atopic dermatitis following external administration of a 0.25% prednicarbate salve (W/O emulsion)].,False,"'Does the phrase ""Prednisolone predisposes pneumonia"" receive at least indirect support from the statement: ""[Reaction of autogenous cortisol production in patients with extensive psoriasis vulgaris or atopic dermatitis following external administration of a 0.25% prednicarbate salve (W/O emulsion)].""?","No, the statement does not provide indirect support for the phrase ""Prednisolone predisposes pneumonia."" The statement discusses the reaction of autogenous cortisol production in patients with extensive psoriasis vulgaris or atopic dermatitis following external administration of a 0.25% prednicarbate salve (W/O emulsion). Prednisolone is not mentioned in this statement, nor is there any connection made between cortisol production, prednisolone, and pneumonia. Prednicarbate is a different glucocorticoid than prednisolone and is not typically associated with an increased risk of pneumonia in patients using it topically as described in the statement." +27027571,Hydrocortisone related to HIV infectious disease,345,"OBJECTIVE: Corticosteroid-binding globulin (CBG), the cortisol transport protein, is cleaved from high-affinity (haCBG) to low-affinity (laCBG) CBG at sites of inflammation releasing bioavailable, anti-inflammatory cortisol.",False,"'Does the phrase ""Hydrocortisone related to HIV infectious disease"" receive at least indirect support from the statement: ""OBJECTIVE: Corticosteroid-binding globulin (CBG), the cortisol transport protein, is cleaved from high-affinity (haCBG) to low-affinity (laCBG) CBG at sites of inflammation releasing bioavailable, anti-inflammatory cortisol.""?","No, the statement does not provide direct or indirect support for the phrase ""Hydrocortisone related to HIV infectious disease."" + The statement discusses the cleavage of corticosteroid-binding globulin (CBG) at sites of inflammation, releasing bioavailable cortisol which is an anti-inflammatory hormone. Hydrocortisone is a synthetic form of cortisol used as a medication for various conditions such as inflammation, allergies, adrenal insufficiency, and autoimmune diseases among others. - However, chorioretinitis is an inflammation of the choroid and retina in the eye which is not explicitly mentioned in the background information. Nonetheless, glucocorticoids like Prednisolone have been widely used in managing various ocular inflammatory conditions due to their potent anti-inflammatory effects on immune cells as well as their ability to stabilize blood-ocular barriers. Therefore, it is plausible that Prednisolone could affect chorioretinitis indirectly through its influence on immune responses and inflammation." -10555139,Prednisolone affects peptic ulcer disease,317,"The incidence of AF was compared among patients who received hydrocortisone, and the effect of low-dose hydrocortisone on AF was estimated using the inverse probability treatment weighting method based on propensity scores.",False,"Is the triple 'Prednisolone affects peptic ulcer disease' supported by the sentence: 'The incidence of AF was compared among patients who received hydrocortisone, and the effect of low-dose hydrocortisone on AF was estimated using the inverse probability treatment weighting method based on propensity scores.'?","No, the statement does not provide direct or indirect support for the claim that ""Prednisolone affects peptic ulcer disease."" The provided statement compares the incidence of atrial fibrillation (AF) among patients who received hydrocortisone and estimates its effect using a specific statistical method. There is no mention of prednisolone or peptic ulcer disease in this context. Therefore, it does not contribute any relevant evidence towards that specific claim." -10183156,Prednisolone affects ulcerative colitis,318,"INTRODUCTION: Intrathecal administration of methotrexate, cytarabine, and hydrocortisone is commonly used to treat and prevent central nervous system involvement in leukemias and lymphomas.",False,"Is the triple 'Prednisolone affects ulcerative colitis' supported by the sentence: 'INTRODUCTION: Intrathecal administration of methotrexate, cytarabine, and hydrocortisone is commonly used to treat and prevent central nervous system involvement in leukemias and lymphomas.'?","No, the statement does not provide indirect support for the phrase ""Prednisolone affects ulcerative colitis."" The introduction mentions intrathecal administration (injection into the spinal canal) of methotrexate, cytarabine, and hydrocortisone for treating central nervous system involvement in leukemias and lymphomas; however, it does not mention prednisolone nor ulcerative colitis. Prednisolone is a synthetic glucocorticoid used primarily for its anti-inflammatory effect in various conditions like asthma, allergies, arthritis, and dermatological diseases; ulcerative colitis is a type of inflammatory bowel disease that may be treated with other corticosteroids such as budesonide or hydrocortisone but not necessarily prednisolone." -9735520,Prednisolone affects Inflammation,319,"INTRODUCTION: Intrathecal administration of methotrexate, cytarabine, and hydrocortisone is commonly used to treat and prevent central nervous system involvement in leukemias and lymphomas.",False,"Is the triple 'Prednisolone affects Inflammation' supported by the sentence: 'INTRODUCTION: Intrathecal administration of methotrexate, cytarabine, and hydrocortisone is commonly used to treat and prevent central nervous system involvement in leukemias and lymphomas.'?","No, the statement does not provide direct or indirect support for the phrase ""Prednisolone affects Inflammation."" The introductory statement discusses the combined use of methotrexate, cytarabine, and hydrocortisone for treating central nervous system involvement in leukemias and lymphomas; however, it does not mention Prednisolone or Inflammation specifically. While hydrocortisone is a type of steroid that can influence inflammation like Prednisolone, it is not explicitly stated that Prednisolone is used for its anti-inflammatory properties in this context. Therefore, no valid conclusion can be drawn regarding Prednisolone's effect on inflammation based on this statement alone." -9361682,Prednisolone affects osteoarthritis,320,"CONCLUSIONS: Early PN did not affect plasma concentrations of ACTH and (free) cortisol, but increased the incidence of septic shock, which statistically explained why more patients on early PN received corticosteroids.",False,"Is the triple 'Prednisolone affects osteoarthritis' supported by the sentence: 'CONCLUSIONS: Early PN did not affect plasma concentrations of ACTH and (free) cortisol, but increased the incidence of septic shock, which statistically explained why more patients on early PN received corticosteroids.'?","No, the statement does not provide direct or indirect support for the phrase ""Prednisolone affects osteoarthritis."" The conclusion is about early parenteral nutrition (PN) affecting plasma concentrations of adrenocorticotropic hormone (ACTH) and cortisol, as well as its impact on septic shock incidence leading to more corticosteroid use in patients on early PN. Prednisolone is not mentioned in the conclusion, nor is there any connection established between PN and osteoarthritis or osteoarthritis and prednisolone use. Therefore, it does not support the claim that prednisolone affects osteoarthritis." -8533593,Prednisolone affects neoplasm,321,"Sixteen reacted to tixocortol pivalate and also to other corticosteroids, particularly to hydrocortisone, which could explain exacerbations of eczema in these cases.",False,"Is the triple 'Prednisolone affects neoplasm' supported by the sentence: 'Sixteen reacted to tixocortol pivalate and also to other corticosteroids, particularly to hydrocortisone, which could explain exacerbations of eczema in these cases.'?","No, the statement does not provide direct or indirect support for the phrase ""Prednisolone affects neoplasm."" The statement discusses patients who reacted to tixocortol pivalate and other corticosteroids such as hydrocortisone, which exacerbated eczema symptoms in these cases. Prednisolone is a corticosteroid like hydrocortisone but it is not explicitly mentioned in the statement as having any effect on neoplasm (abnormal growths such as tumors). + + Although hydrocortisone has immunosuppressive effects which could theoretically impact immune responses in HIV infection, there is no explicit mention of HIV or any infectious disease in the statement provided. Therefore, it would be inappropriate to infer any connection between hydrocortisone and HIV infectious disease based solely on this information." +25927636,Hydrocortisone related to cardiac arrest,346,The propensity to develop type 1 diabetes or type 2 diabetes/metabolic syndrome depends on the propensity to release of cortisol which correlates with race.,False,"'Does the phrase ""Hydrocortisone related to cardiac arrest"" receive at least indirect support from the statement: ""The propensity to develop type 1 diabetes or type 2 diabetes/metabolic syndrome depends on the propensity to release of cortisol which correlates with race.""?","No, the statement does not provide indirect support for the phrase ""Hydrocortisone related to cardiac arrest."" - To further clarify: + The statement discusses the relationship between race and the propensity to release cortisol, which in turn influences the development of type 1 diabetes or type 2 diabetes/metabolic syndrome. Cortisol is a hormone that the body produces in response to stress; hydrocortisone is a synthetic form of cortisol often used in medications such as corticosteroids. - - Neoplasm refers to new and abnormal growths in the body, which can be benign (non-cancerous) or malignant (cancerous). - - Prednisolone is a synthetic glucocorticoid, which is commonly used in treating inflammatory diseases like asthma, rheumatoid arthritis, inflammatory bowel disease, etc., but it has also been used in some cancer treatments due to its immunosuppressive properties. + While both cortisol and hydrocortisone have similar effects on the body (including increasing blood sugar levels), they are not identical in their actions or consequences. Moreover, the statement does not mention anything about hydrocortisone use, cardiac arrest risk, or even cardiovascular health in general. - However, based on the provided statement alone, there is no mention or evidence implying that prednis" -7800426,Prednisolone affects acute lymphoblastic leukemia,322,"Finally, transient pre-treatment of healthy humans with cortisol induces a bi-phasic response during a later, delayed systemic inflammatory response: an intermediate cortisol concentration augments inflammation while a high cortisol concentration is neither pro- nor anti-inflammatory.",False,"Is the triple 'Prednisolone affects acute lymphoblastic leukemia' supported by the sentence: 'Finally, transient pre-treatment of healthy humans with cortisol induces a bi-phasic response during a later, delayed systemic inflammatory response: an intermediate cortisol concentration augments inflammation while a high cortisol concentration is neither pro- nor anti-inflammatory.'?","No, the statement does not provide direct support for the claim that prednisolone affects acute lymphoblastic leukemia (ALL). The statement discusses cortisol's effect on inflammation in healthy humans, while prednisolone is a synthetic glucocorticoid similar to cortisol but with more potent anti-inflammatory effects. Although both cortisol and prednisolone have implications in treating leukemia due to their anti-inflammatory properties, the provided statement does not establish any connection between prednisolone and ALL specifically. + Therefore, without additional information linking hydrocortisone use, cortisol release, race, and cardiac arrest risk, it is not possible to infer any relationship between these factors based on the provided statement alone." +25797574,Hydrocortisone related to lymphoma,347,"CIRCI is characterized by an inadequate production of cortisol in relation to an increased demand during periods of severe stress, particularly in critical illnesses such as sepsis or septic shock.",True,"'Does the phrase ""Hydrocortisone related to lymphoma"" receive at least indirect support from the statement: ""CIRCI is characterized by an inadequate production of cortisol in relation to an increased demand during periods of severe stress, particularly in critical illnesses such as sepsis or septic shock.""?","Yes, indirectly it does. The statement suggests that there is a relationship between cortisol levels and severe stress conditions such as sepsis or septic shock (CIRCI). Hydrocortisone is a synthetic form of cortisol, a hormone that the body produces in response to stress. Therefore, if lymphoma is a condition that causes severe stress leading to increased demand for cortisol, then it could be inferred that hydrocortisone might be related to lymphoma. However, this is a very indirect inference and would need much more direct evidence to confirm any causal relationship. It's also important to note that correlation does not imply causation." +25131277,Hydrocortisone related to Crohn disease,348,Synacthen test diagnosed Addison's disease with a clear deficiency of cortisol production.,False,"'Does the phrase ""Hydrocortisone related to Crohn disease"" receive at least indirect support from the statement: ""Synacthen test diagnosed Addison's disease with a clear deficiency of cortisol production.""?","No, the statement ""Synacthen test diagnosed Addison's disease with a clear deficiency of cortisol production"" does not provide indirect support for the phrase ""Hydrocortisone related to Crohn disease."" - + The Synacthen test is used for diagnosing adrenal insufficiency by measuring the body's ability to produce cortisol in response to synthetic ACTH (Synacthen). Addison's disease is characterized by deficient cortisol production due to damage in the adrenal glands. - However, it is important to acknowledge that glucocorticoids like prednisolone have been widely used in treating ALL due to their ability to induce apoptosis in leukemic blasts, suppress inflammation, and inhibit cell proliferation [1]. While the statement does not provide direct evidence for prednisolone affecting ALL, it does contribute to understanding how corticosteroids can influence immune responses in general. + Hydrocortisone is a synthetic form of cortisol used primarily for treating adrenal insufficiency (including Addison's disease), inflammatory conditions (such as arthritis), allergic reactions, and certain types of cancer. - + Crohn's disease is an inflammatory bowel disease that can affect any part of the gastrointestinal tract from mouth to anus. Although corticosteroids like hydrocortisone can be used in treating Crohn's disease symptoms (such as inflammation), it does not establish any direct relationship between hydrocortisone and" +19793698,Hydrocortisone related to alcohol abuse,349,"Enhanced cortisol production rates, free cortisol, and 11beta-HSD-1 expression correlate with visceral fat and insulin resistance in men: effect of weight loss.",False,"'Does the phrase ""Hydrocortisone related to alcohol abuse"" receive at least indirect support from the statement: ""Enhanced cortisol production rates, free cortisol, and 11beta-HSD-1 expression correlate with visceral fat and insulin resistance in men: effect of weight loss.""?","No, the statement does not provide indirect support for the phrase ""Hydrocortisone related to alcohol abuse."" The statement discusses enhanced cortisol production rates, free cortisol, and 11beta-HSD-1 expression in relation to visceral fat and insulin resistance in men, following weight loss. Hydrocortisone is a synthetic form of cortisol, but the statement does not make any connection between cortisol/hydrocortisone and alcohol abuse. Therefore, it is not appropriate to infer any relationship between hydrocortisone and alcohol abuse based on this statement alone." +19531872,Hydrocortisone related to atrial fibrillation,350,"Obesity is also related to dysregulation of cortisol production by the pre-receptor enzyme, 11beta-hydroxysteroid dehydrogenase, and we speculate that this may have a role in the pathogenesis of obesity and raised ICP seen in IIH.",False,"'Does the phrase ""Hydrocortisone related to atrial fibrillation"" receive at least indirect support from the statement: ""Obesity is also related to dysregulation of cortisol production by the pre-receptor enzyme, 11beta-hydroxysteroid dehydrogenase, and we speculate that this may have a role in the pathogenesis of obesity and raised ICP seen in IIH.""?","No, the statement does not provide direct or indirect support for the phrase ""Hydrocortisone related to atrial fibrillation."" The statement discusses obesity's relationship with cortisol production dysregulation through the enzyme 11beta-hydroxysteroid dehydrogenase and its potential impact on intracranial pressure in IIH (Idiopathic Intracranial Hypertension). Hydrocortisone is a synthetic form of cortisol, but there is no mention of atrial fibrillation in the provided context. Therefore, it is not possible to draw any connections between hydrocortisone use and atrial fibrillation based on this statement alone." +18705900,Hydrocortisone related to phobic disorder,351,"This is an extremely rare case of bilateral adrenal tumors, in which the left adrenocortical tumor produced and secreted cortisol or both cortisol and aldosterone and the right one produced and secreted both aldosterone and cortisol, as confirmed by clinical findings and pathological studies using immunohistochemical analysis.",False,"'Does the phrase ""Hydrocortisone related to phobic disorder"" receive at least indirect support from the statement: ""This is an extremely rare case of bilateral adrenal tumors, in which the left adrenocortical tumor produced and secreted cortisol or both cortisol and aldosterone and the right one produced and secreted both aldosterone and cortisol, as confirmed by clinical findings and pathological studies using immunohistochemical analysis.""?","No, the statement does not provide indirect support for the phrase ""Hydrocortisone related to phobic disorder"". The statement discusses an extremely rare case of bilateral adrenal tumors that produce and secrete cortisol and aldosterone. While hydrocortisone is a synthetic form of cortisol, there is no mention of any connection between these tumors, their secretions, and phobic disorders in the statement provided. Therefore, it is not possible to infer any relationship between hydrocortisone and phobic disorder based on this information alone." +15155784,Hydrocortisone related to psoriasis,352,"We conclude that the clinical picture of late-onset adrenal insufficiency in preterm infants is not a result of an absolute deficiency of cortisol production, but may be a result of a limited ability to synthesize sufficient cortisol for the degree of clinical stress.",False,"'Does the phrase ""Hydrocortisone related to psoriasis"" receive at least indirect support from the statement: ""We conclude that the clinical picture of late-onset adrenal insufficiency in preterm infants is not a result of an absolute deficiency of cortisol production, but may be a result of a limited ability to synthesize sufficient cortisol for the degree of clinical stress.""?","No, the statement does not provide indirect support for the phrase ""Hydrocortisone related to psoriasis"". The conclusion in the statement is about late-onset adrenal insufficiency in preterm infants, which is related to cortisol production but not hydrocortisone use. Psoriasis is an autoimmune skin condition that is not mentioned in the statement. Therefore, there is no connection between hydrocortisone (a synthetic form of cortisol) and psoriasis in this context." +14891361,"Hydrocortisone related to dermatitis, atopic",353,"Ironically, despite our understanding of the various stressors that promote chronic adult-onset asthma, most of which are known to elevate cortisol production via the hypothalamic-pituitary-adrenal (HPA) axis, inhaled and systemic corticosteroids are the mainstay for the treatment of chronic asthma.",True,"'Does the phrase ""Hydrocortisone related to dermatitis, atopic"" receive at least indirect support from the statement: ""Ironically, despite our understanding of the various stressors that promote chronic adult-onset asthma, most of which are known to elevate cortisol production via the hypothalamic-pituitary-adrenal (HPA) axis, inhaled and systemic corticosteroids are the mainstay for the treatment of chronic asthma.""?","Yes, indirect support can be inferred from the statement provided for the phrase ""Hydrocortisone related to dermatitis, atopic."" Hydrocortisone is a type of corticosteroid that is often used in treating various conditions related to inflammation and allergies, such as atopic dermatitis (eczema). - + The statement highlights that corticosteroids like hydrocortisone are used as a primary treatment for chronic adult-onset asthma despite stressors promoting chronic asthma being known to elevate cortisol production via the HPA axis. This suggests that administering corticosteroids like hydrocortisone could help counteract the effects of increased cortisol levels in some instances. - [1] Pui, C. H., & Evans, W. E. (" -7395227,Prednisolone affects systemic lupus erythematosus,323,"Adrenaline induces the early posthypoglycaemic insulin resistance, whereas cortisol and growth hormone are important for the insulin resistance that is observed later following hypoglycaemia.",False,"Is the triple 'Prednisolone affects systemic lupus erythematosus' supported by the sentence: 'Adrenaline induces the early posthypoglycaemic insulin resistance, whereas cortisol and growth hormone are important for the insulin resistance that is observed later following hypoglycaemia.'?","No, the statement does not provide direct or indirect support for the phrase ""Prednisolone affects systemic lupus erythematosus"". The statement discusses the effects of adrenaline, cortisol, and growth hormone on insulin resistance following hypoglycaemia, while prednisolone is not mentioned at all in this context. Prednisolone is a synthetic glucocorticoid often used in treating inflammatory diseases such as systemic lupus erythematosus (SLE), but its mechanism of action is distinct from that of adrenaline, cortisol, and growth hormone in relation to insulin resistance in hypoglycaemia. Hence, there is no connection between these two pieces of information that could provide support for the initial phrase about prednisolone affecting SLE." -21722189,Prednisolone affects Prednisone,324,"RESULTS: Within 24 hours following TBI, the concentrations of total cortisol, ACTH and gastrin increased proportionally to the severity of injury, especially significant in the experimental group (P less than 0.05).",False,"Is the triple 'Prednisolone affects Prednisone' supported by the sentence: 'RESULTS: Within 24 hours following TBI, the concentrations of total cortisol, ACTH and gastrin increased proportionally to the severity of injury, especially significant in the experimental group (P less than 0.05).'?","No, the statement does not provide direct or indirect support for the phrase ""Prednisolone affects Prednisone."" The provided result is about increased concentrations of total cortisol, ACTH (adrenocorticotropic hormone), and gastrin following traumatic brain injury (TBI), which is significant in the experimental group. Prednisolone and Prednisone are both corticosteroids used in medical treatments; however, there is no mention of either in the given result, nor any comparison between them that would suggest an effect of one on the other." -9655099,Prednisolone has input Prednisone,325,NEW OR UNIQUE INFORMATION PROVIDED: This case is the first published report of hydrocortisone-responsive hypotension and transient CIRCI associated with naturally occurring septic shock in a dog.,False,Is the triple 'Prednisolone has input Prednisone' supported by the sentence: 'NEW OR UNIQUE INFORMATION PROVIDED: This case is the first published report of hydrocortisone-responsive hypotension and transient CIRCI associated with naturally occurring septic shock in a dog.'?,"No, the phrase ""Prednisolone has input Prednisone"" does not receive indirect support from the statement provided. + However, it is essential to acknowledge that atopic dermatitis is not asthma; they are separate conditions that can coexist in some individuals but have different underlying causes and mechanisms. Therefore, while hydrocortisone may be beneficial in managing atopic dermatitis in patients with chronic asthma, it may not necessarily impact asthma symptoms directly due to its relationship with cortisol production via the HPA" +14483328,Hydrocortisone related to bronchopulmonary dysplasia,354,Glucocorticoid insufficiency is common during sepsis and may result from insufficient production of cortisol or peripheral tissues resistance.,True,"'Does the phrase ""Hydrocortisone related to bronchopulmonary dysplasia"" receive at least indirect support from the statement: ""Glucocorticoid insufficiency is common during sepsis and may result from insufficient production of cortisol or peripheral tissues resistance.""?","Yes, indirectly it does. Hydrocortisone is a type of glucocorticoid, which is a class of steroid hormones that includes cortisol. Bronchopulmonary dysplasia (BPD) is a chronic lung disease in infants often associated with premature birth and respiratory distress syndrome. - - The statement discusses a case report in dogs where hydrocortisone was used for hypotension and transient Critical Illness-Related Corticosteroid Insufficiency (CIRCI) associated with naturally occurring septic shock. Prednisolone is a synthetic glucocorticoid similar to Prednisone but metabolized differently in dogs. The statement does not provide any information about Prednisolone affecting Prednisone levels in dogs or otherwise. + The statement provided suggests that glucocorticoid insufficiency, which can be due to decreased cortisol production or peripheral tissue resistance, is common during sepsis. Hydrocortisone is often used in clinical settings to treat conditions associated with glucocorticoid insufficiency. - - To support ""Prednisolone has input Prednisone,"" one would need evidence showing Prednisolone metabolism leading to Prednisone production in dogs specifically; however, it is generally accepted that Prednisolone is metabolized into inactive compounds in dogs rather than being converted into Prednisone. Therefore, there is no indirect support from the given statement for ""Prednisolone has input Prednisone.""" -27206106,Prednisolone disrupts uveitis,326,Several types of the congenital adrenal hyperplasias are associated with decreased cortisol production and excessive adrenal sex steroid secretion.,False,Is the triple 'Prednisolone disrupts uveitis' supported by the sentence: 'Several types of the congenital adrenal hyperplasias are associated with decreased cortisol production and excessive adrenal sex steroid secretion.'?,"No, the statement does not provide direct or indirect support for the phrase ""Prednisolone disrupts uveitis."" The association between certain types of congenital adrenal hyperplasias (CAH) and decreased cortisol production along with excessive adrenal sex steroid secretion is related to impaired cortisol synthesis due to genetic defects in enzymes involved in steroidogenesis. Prednisolone is a synthetic glucocorticoid used primarily for its potent anti-inflammatory effects in various conditions like uveitis, an inflammation of the uveal tract in the eye. Although both statements discuss corticosteroids (cortisol and prednisolone), they describe different biological processes that do not inherently support the disruption of uveitis by prednisolone." -26515767,Prednisolone disrupts neoplasm,327,[Use of cryo-apheresis in the treatment of patients with cortisol-dependent bronchial asthma].,False,Is the triple 'Prednisolone disrupts neoplasm' supported by the sentence: '[Use of cryo-apheresis in the treatment of patients with cortisol-dependent bronchial asthma].'?,"No, the statement does not provide indirect support for the phrase ""Prednisolone disrupts neoplasm."" The provided statement discusses cryo-apheresis in the treatment of cortisol-dependent bronchial asthma patients, without mentioning Prednisolone or its effects on neoplasms (abnormal growths that can become cancerous). Therefore, it does not offer any evidence or implications regarding Prednisolone's impact on neoplasm disruption. + Therefore, while the statement does not explicitly mention bronchopulmonary dysplasia, it does suggest a link between glucocorticoid insufficiency and conditions that may require hydrocortisone treatment. This could indirectly support the association between hydrocortisone and bronchopulmonary dysplasia, as both are related to glucocorticoid insufficiency. However, it's important to note that this is an indirect association and further research would be needed to confirm" +14450267,Hydrocortisone related to adrenal cortex neoplasm,355,"This likely represents an adaptive response to LTH, to prevent excessive cortisol production that would restrict fetal growth and potentially induce preterm delivery.",False,"'Does the phrase ""Hydrocortisone related to adrenal cortex neoplasm"" receive at least indirect support from the statement: ""This likely represents an adaptive response to LTH, to prevent excessive cortisol production that would restrict fetal growth and potentially induce preterm delivery.""?","No, the phrase ""Hydrocortisone related to adrenal cortex neoplasm"" does not receive indirect support from the statement provided. - + The statement discusses an adaptive response related to hydrocortisone (cortisol), but it does not establish a connection between hydrocortisone and adrenal cortex neoplasm (a tumor of the adrenal gland). An adrenal cortex neoplasm would be a pathological condition involving uncontrolled cell growth in the adrenal gland, potentially leading to overproduction of hormones like cortisol. - To further clarify, Prednisolone is a synthetic glucocorticoid often used as an anti-inflammatory drug in various conditions such as asthma, rheumatoid arthritis, and inflammatory bowel disease [1]. Although glucocorticoids have been linked to cancer development in some instances due to their immunosuppressive effects [2], there is no direct information in the statement that would support Prednisolone specifically disrupting neoplasms. + In contrast, the statement suggests that lowering cortisol levels through an adaptive response might be beneficial in preventing excessive cortisol production that could negatively impact fetal growth and preterm delivery risk. This statement does not imply that hydrocortisone is related to an adrenal cortex neoplasm but rather focuses on its physiological function in fetal development under specific conditions (LTH). - + Therefore, without further evidence linking hydrocortisone levels directly with adrenal cortex neoplasm, it is not reasonable to infer" +14387016,Hydrocortisone related to cirrhosis of liver,356,"The reduction in local cortisol production which diminishes the endogenous anti-inflammatory effects, also allows for the progression of both vascular and pulmonary inflammation.",False,"'Does the phrase ""Hydrocortisone related to cirrhosis of liver"" receive at least indirect support from the statement: ""The reduction in local cortisol production which diminishes the endogenous anti-inflammatory effects, also allows for the progression of both vascular and pulmonary inflammation.""?","No, the statement does not provide direct or indirect support for the phrase ""Hydrocortisone related to cirrhosis of liver."" The statement discusses the reduction in local cortisol production and its implications on vascular and pulmonary inflammation. Hydrocortisone is a synthetic form of cortisol, a hormone that the body naturally produces in response to stress. Although it has anti-inflammatory effects, the statement does not mention any connection between hydrocortisone use and cirrhosis of the liver. Therefore, it is not possible to make any inferences about hydrocortisone's relationship to liver cirrhosis based on the provided statement alone." +14360687,Hydrocortisone related to dermatitis,357,"CONCLUSIONS: Patients with newly diagnosed, untreated PC yielded significantly higher cortisol and lower estradiol serum concentrations than controls.",False,"'Does the phrase ""Hydrocortisone related to dermatitis"" receive at least indirect support from the statement: ""CONCLUSIONS: Patients with newly diagnosed, untreated PC yielded significantly higher cortisol and lower estradiol serum concentrations than controls.""?","No, the statement does not provide direct or indirect support for the phrase ""Hydrocortisone related to dermatitis."" The conclusion is about cortisol serum concentrations in patients with prostate cancer (PC) compared to controls, not about hydrocortisone or dermatitis. Hydrocortisone is a synthetic form of cortisol, but no information is given about its use or relation to dermatitis in this statement. Therefore, it is not possible to make any conclusions about hydrocortisone's relationship to dermatitis based on this information alone." +13844584,Hydrocortisone related to acute myeloid leukemia,358,"The tumour secreted excessive cortisol and dehydroepiandrosterone-sulphate (DHEA-S), and had invaded the right hepatic lobe and vena cava.",False,"'Does the phrase ""Hydrocortisone related to acute myeloid leukemia"" receive at least indirect support from the statement: ""The tumour secreted excessive cortisol and dehydroepiandrosterone-sulphate (DHEA-S), and had invaded the right hepatic lobe and vena cava.""?","No, the statement does not provide indirect support for the phrase ""Hydrocortisone related to acute myeloid leukemia."" - + The statement suggests that a tumor is producing cortisol and DHEA-S (dehydroepiandrosterone-sulphate), which are steroid hormones produced by the adrenal gland. Hydrocortisone is a synthetic form of cortisol often used in medications. While it is true that acute myeloid leukemia (AML) cells can produce steroid hormones, the statement does not indicate that hydrocortisone is involved in this particular case. Therefore, it does not provide support for the claimed relationship between hydrocortisone and AML." +13213365,Hydrocortisone related to chronic primary adrenal insufficiency,359,Replacement doses of hydrocortisone were administered throughout treatment to counteract potential adrenal insufficiency secondary to the ketoconazole.,True,"'Does the phrase ""Hydrocortisone related to chronic primary adrenal insufficiency"" receive at least indirect support from the statement: ""Replacement doses of hydrocortisone were administered throughout treatment to counteract potential adrenal insufficiency secondary to the ketoconazole.""?","Yes, indirect support can be inferred from the statement. The provided statement indicates that hydrocortisone was administered throughout treatment to counteract potential adrenal insufficiency secondary to ketoconazole use. This suggests a relationship between hydrocortisone and adrenal insufficiency, which aligns with the concept of hydrocortisone being related to chronic primary adrenal insufficiency. However, it is important to note that this relationship is not explicitly stated as primary adrenal insufficiency in the original statement; rather, it refers to adrenal insufficiency that is secondary to ketoconazole use. Nonetheless, it does provide some level of indirect support for the initial phrase based on the broader context of adrenal insufficiency." +12756660,Hydrocortisone related to borderline personality disorder,360,Amplication by hydrocortisone of the induction of cytotoxic response in vitro to syngeneic murine leukemias.,False,"'Does the phrase ""Hydrocortisone related to borderline personality disorder"" receive at least indirect support from the statement: ""Amplication by hydrocortisone of the induction of cytotoxic response in vitro to syngeneic murine leukemias.""?","No, the statement ""Amplification by hydrocortisone of the induction of cytotoxic response in vitro to syngeneic murine leukemias"" does not provide indirect support for the connection between hydrocortisone and borderline personality disorder (BPD). The statement is about hydrocortisone amplifying cytotoxic responses in vitro (in a laboratory setting) against syngeneic murine leukemias (mouse leukemias). This is related to immunology and cancer treatment rather than psychiatry or personality disorders like BPD. - + The two subjects - hydrocortisone and borderline personality disorder - may be connected in some broader contexts (e.g., hydrocortisone being used as a medication in psychiatric care), but the provided statement does not contain any information linking hydrocortisone to BPD specifically. Therefore, it does not indirectly support the claimed connection between hydrocortisone and borderline personality disorder based on this statement alone." +12576998,Hydrocortisone related to Hypoxemia,361,The results demonstrated that the intrarectal dose of indomethacin and hydrocortisone inhibited the development of tumors from microscopic carcinoma lesions in the large bowel and growing further.,False,"'Does the phrase ""Hydrocortisone related to Hypoxemia"" receive at least indirect support from the statement: ""The results demonstrated that the intrarectal dose of indomethacin and hydrocortisone inhibited the development of tumors from microscopic carcinoma lesions in the large bowel and growing further.""?","No, the statement ""The results demonstrated that the intrarectal dose of indomethacin and hydrocortisone inhibited the development of tumors from microscopic carcinoma lesions in the large bowel and growing further"" does not provide indirect support for the phrase ""Hydrocortisone related to Hypoxemia"". - References: + The statement discusses the effect of indomethacin and hydrocortisone on tumor development in the large bowel, which is unrelated to hypoxemia, a condition characterized by low oxygen levels in the blood. Hypoxemia is not mentioned nor implied in the statement. Therefore, it does not offer any support for a relationship between hydrocortisone and hypoxemia." +11888652,Hydrocortisone related to congenital adrenal hyperplasia,362,"Growth of ovarian, lung, breast, and kidney carcinomas was increased by 136%, 126%, 78% and 69%, respectively, whereas melanomas, sarcomas, and colon tumors were inhibited by hydrocortisone.",False,"'Does the phrase ""Hydrocortisone related to congenital adrenal hyperplasia"" receive at least indirect support from the statement: ""Growth of ovarian, lung, breast, and kidney carcinomas was increased by 136%, 126%, 78% and 69%, respectively, whereas melanomas, sarcomas, and colon tumors were inhibited by hydrocortisone.""?","No, the statement does not provide indirect support for the phrase ""Hydrocortisone related to congenital adrenal hyperplasia"". - + The statement presents data on the effects of hydrocortisone on various types of carcinomas and tumors. However, congenital adrenal hyperplasia (CAH) is a genetic disorder that affects the adrenal glands' production of certain hormones, most commonly cortisol and aldosterone. Hydrocortisone is a synthetic form of cortisol, a hormone that the adrenal gland produces naturally. - [1] ""Prednisolone."" MedlinePlus," -26379811,Prednisolone disrupts contact dermatitis,328,Hypotension after recruitment was reduced by HC (0 vs. 30%).,False,Is the triple 'Prednisolone disrupts contact dermatitis' supported by the sentence: 'Hypotension after recruitment was reduced by HC (0 vs. 30%).'?,"No, the statement ""Hypotension after recruitment was reduced by HC (0 vs. 30%)"" does not provide indirect support for the phrase ""Prednisolone disrupts contact dermatitis"". The two statements discuss different aspects of medical interventions - one focuses on hypotension reduction by HC (hydrocortisone) in recruited individuals while the other refers to Prednisolone's impact on contact dermatitis. There is no connection between these two variables in the provided statement that would allow us to infer any supportive relationship between them." -25763558,Prednisolone disrupts pneumonia,329,Fetal plasma cortisol concentrations were increased ( P < 0.05) during all levels of hypoxia.,False,Is the triple 'Prednisolone disrupts pneumonia' supported by the sentence: 'Fetal plasma cortisol concentrations were increased ( P < 0.05) during all levels of hypoxia.'?,"No, the statement does not provide direct or indirect support for the phrase ""Prednisolone disrupts pneumonia."" The finding that fetal plasma cortisol concentrations increase during hypoxia does not necessarily imply a connection to prednisolone or pneumonia. Prednisolone is a synthetic glucocorticoid often used in clinical settings for its anti-inflammatory effects, while pneumonia is an infection causing inflammation in lung tissue. The statement discusses an increase in cortisol levels due to hypoxia in fetal plasma; however, it does not establish a relationship between prednisolone usage and disrupted pneumonia. Further investigation involving prednisolone, pneumonia models, and hypoxia would be required to establish such a connection." -25233555,Prednisolone disrupts allergic disease,330,"INTRA-CELL CORTISOL: Attention is also focused on the potential implication of cortisol in the genesis of metabolic syndrome, because cortisol is a potent antagonist of the effect of insulin and its presence in excess enhances visceral obesity and insulin resistance.",False,"Is the triple 'Prednisolone disrupts allergic disease' supported by the sentence: 'INTRA-CELL CORTISOL: Attention is also focused on the potential implication of cortisol in the genesis of metabolic syndrome, because cortisol is a potent antagonist of the effect of insulin and its presence in excess enhances visceral obesity and insulin resistance.'?","No, the statement does not provide direct or indirect support for the phrase ""Prednisolone disrupts allergic disease."" The provided statement discusses cortisol's potential implications in metabolic syndrome, focusing on its antagonistic effect on insulin and its contribution to visceral obesity and insulin resistance. Prednisolone is a synthetic glucocorticoid often prescribed for its potent anti-inflammatory properties; however, it is not explicitly linked to allergic disease disruption in either statement nor in any known allopathic medical contexts. + While hydrocortisone is used in treating CAH to replace deficient cortisol, the statement does not provide any information about hydrocortisone's relationship to CAH. It only discusses hydrocortisone's effects on various carcinomas and tumors, which is unrelated to CAH. Therefore, it does not provide indirect support for the phrase ""Hydrocortisone related to congenital adrenal hyperplasia""." +11866289,Hydrocortisone related to nicotine dependence,363,Insufficient cortisol limits the ability of the sick newborn to handle stress and inhibit pulmonary inflammation.,False,"'Does the phrase ""Hydrocortisone related to nicotine dependence"" receive at least indirect support from the statement: ""Insufficient cortisol limits the ability of the sick newborn to handle stress and inhibit pulmonary inflammation.""?","No, the statement does not provide indirect support for the phrase ""Hydrocortisone related to nicotine dependence."" - To provide indirect support for ""Prednisolone disrupts allergic disease,"" there would need to be some connection between prednisolone, cortisol (as glucocorticoids share many properties), and allergic disease pathophysiology. Although prednisolone can modulate immune responses related to allergic disease (such as reducing eosinophil numbers), the statement in question does not provide sufficient evidence for such an assertion. + The statement discusses the role of cortisol, a hormone that the body produces in response to stress, in newborns. It suggests that insufficient cortisol levels can limit a newborn's ability to manage stress and inhibit pulmonary inflammation. - Moreover, it is essential to consider that allergic disease is complex in nature and involves various cellular components (e.g., mast cells, basophils" -14331279,Prednisolone disrupts hypereosinophilic syndrome,331,The effect of hydrocortisone on standardized skin-surface trauma.,False,Is the triple 'Prednisolone disrupts hypereosinophilic syndrome' supported by the sentence: 'The effect of hydrocortisone on standardized skin-surface trauma.'?,"No, the statement ""The effect of hydrocortisone on standardized skin-surface trauma"" does not provide indirect support for the phrase ""Prednisolone disrupts hypereosinophilic syndrome."" + Hydrocortisone is a synthetic form of cortisol often used in medical treatments to reduce inflammation. While both cortisol and hydrocortisone have similar effects in the body, nicotine dependence is not mentioned or implied in the statement. Nicotine dependence is a complex process involving multiple factors, including genetic predisposition, environmental influences, and addiction behavior, which are not addressed in the statement. - Hydrocortisone and Prednisolone are both corticosteroids, but they have different chemical structures and pharmacological properties. Hydrocortisone is primarily used for its anti-inflammatory effects in treating conditions like skin trauma, while Prednisolone is often used in managing disorders associated with excessive immune response like hypereosinophilic syndrome due to its stronger immunosuppressive properties. + Therefore, without additional context or evidence linking hydrocortisone to nicotine dependence, it is inappropriate to infer such a connection based on the provided statement alone." +11530989,Hydrocortisone related to pneumonia,364,"BACKGROUND: Hepatic 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) activity, which converts cortisone (inactive) to cortisol, is downregulated in obesity.",False,"'Does the phrase ""Hydrocortisone related to pneumonia"" receive at least indirect support from the statement: ""BACKGROUND: Hepatic 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) activity, which converts cortisone (inactive) to cortisol, is downregulated in obesity.""?","No, the statement does not provide direct or indirect support for the phrase ""Hydrocortisone related to pneumonia."" The statement discusses hepatic 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) activity in obesity, which is responsible for converting cortisone (inactive) to cortisol (active). However, it does not mention hydrocortisone (a synthetic form of cortisol) nor does it provide any connection between these steroid hormones and pneumonia." +11442939,Hydrocortisone related to prostate cancer,365,"High-dose hydrocortisone treatment given in the first few hours after a traumatic experience was associated with significant favorable changes in the trajectory of exposure to trauma, as expressed by the reduced risk of the development of PTSD post-trauma.",False,"'Does the phrase ""Hydrocortisone related to prostate cancer"" receive at least indirect support from the statement: ""High-dose hydrocortisone treatment given in the first few hours after a traumatic experience was associated with significant favorable changes in the trajectory of exposure to trauma, as expressed by the reduced risk of the development of PTSD post-trauma.""?","No, the statement does not provide indirect support for the phrase ""Hydrocortisone related to prostate cancer."" The statement discusses the association between high-dose hydrocortisone treatment and reduced risk of post-traumatic stress disorder (PTSD) development after a traumatic experience. This is unrelated to prostate cancer. Therefore, it does not offer any relevant information or implications regarding hydrocortisone's potential relationship with prostate cancer." +11089023,Hydrocortisone related to pancreatitis,366,"Under normal conditions, stress induces increased cortisol secretion that counteracts inflammatory reactions.",True,"'Does the phrase ""Hydrocortisone related to pancreatitis"" receive at least indirect support from the statement: ""Under normal conditions, stress induces increased cortisol secretion that counteracts inflammatory reactions.""?","Yes, indirectly it does support the statement ""Hydrocortisone related to pancreatitis"". This is because hydrocortisone is a synthetic form of cortisol, a hormone that the body naturally produces in response to stress. The statement suggests that cortisol has an anti-inflammatory effect, which is true - one of cortisol's primary functions is to reduce inflammation in the body. - The study referenced in the statement focuses on hydrocortisone's effect on skin-surface trauma, which is an entirely different physiological context than hypereosinophilic syndrome. Therefore, even though both drugs belong to the same class (corticosteroids), we cannot infer that one disrupts hypereosinophilic syndrome based on the other's effect on skin trauma. + However, like all medications, hydrocortisone can have side effects, one of which can be pancreatitis, particularly at high doses or in patients with certain risk factors. Therefore, while the statement about cortisol's anti-inflammatory effects is correct, it doesn't tell the whole story about hydrocortisone use, which can indeed be related to pancreatitis under certain conditions. - To establish whether prednisolone disrupts hypereosinophilic syndrome, direct evidence from" -10594561,Prednisolone disrupts asthma,332,The action of hydrocortisone in synovial inflammation.,False,Is the triple 'Prednisolone disrupts asthma' supported by the sentence: 'The action of hydrocortisone in synovial inflammation.'?,"No, the statement ""The action of hydrocortisone in synovial inflammation"" does not provide indirect support for the phrase ""Prednisolone disrupts asthma."" Hydrocortisone and Prednisolone are both corticosteroids used in treating inflammation; however, they act on different cells and tissues in the body. Hydrocortisone is primarily used for treating inflammation in joints (synovial inflammation), whereas Prednisolone is often used for treating asthma due to its action on lung tissue. + It's important to note that correlation does not imply causation, and while there may be a relationship between hydrocortisone use and pancreatitis, it doesn't necessarily mean that the hydrocortisone is the direct cause of the pancreatitis. Other factors, such as the patient" +10649902,Hydrocortisone related to myocardial infarction,367,Hydrocortisone (HC) reduced the macrophage content of four murine tumors to less than half of control values.,False,"'Does the phrase ""Hydrocortisone related to myocardial infarction"" receive at least indirect support from the statement: ""Hydrocortisone (HC) reduced the macrophage content of four murine tumors to less than half of control values.""?","No, the statement ""Hydrocortisone (HC) reduced the macrophage content of four murine tumors to less than half of control values"" does not provide indirect support for the claim that ""Hydrocortisone is related to myocardial infarction."" The first statement refers to an observed effect of hydrocortisone on macrophage content in tumors in mice while the second statement relates to potential implications of hydrocortisone in myocardial infarction in humans (or other animals). - Although both drugs have anti-inflammatory properties, their specific effects on different cells and tissues limit the transferability of evidence from one drug to another. Therefore, it is essential to rely on studies that investigate Prednisolone's effects on asthma when assessing its potential benefits for treating that particular condition." -8854473,Prednisolone disrupts Inflammation,333,"The effects of stressful life events, coping, and cortisol on HIV infection.",False,"Is the triple 'Prednisolone disrupts Inflammation' supported by the sentence: 'The effects of stressful life events, coping, and cortisol on HIV infection.'?","No, the statement ""The effects of stressful life events, coping, and cortisol on HIV infection"" does not provide direct or indirect support for the phrase ""Prednisolone disrupts Inflammation."" + The two statements involve different biological contexts (cancer vs cardiovascular disease), different species (mice vs humans/other animals), different endpoints (macrophage content in tumors vs myocardial infarction), and different directions of effect (reduction in macrophage content vs potential increase in myocardial infarction risk). - Prednisolone is a synthetic glucocorticoid, which is a class of steroid hormones that includes cortisol. Glucocorticoids like prednisolone have anti-inflammatory effects by suppressing the immune system. However, the statement provided discusses stressful life events, coping mechanisms, and cortisol in relation to HIV infection, but it does not mention prednisolone nor inflammation disruption explicitly or implicitly. + While hydrocortisone has been associated with both anti-inflammatory effects (which could potentially reduce tumor growth by reducing macrophage content) and pro-inflammatory effects (which could potentially contribute to cardiovascular disease by increasing inflammation)," +10522181,Hydrocortisone related to osteoarthritis,368,"Further, because infant formula contains only trace amounts of glucocorticoids, these findings suggest that cortisol in milk is a novel biological pathway through which breastfeeding may protect against later obesity.",False,"'Does the phrase ""Hydrocortisone related to osteoarthritis"" receive at least indirect support from the statement: ""Further, because infant formula contains only trace amounts of glucocorticoids, these findings suggest that cortisol in milk is a novel biological pathway through which breastfeeding may protect against later obesity.""?","No, the statement does not provide indirect support for the phrase ""Hydrocortisone related to osteoarthritis"". The statement discusses the potential protective effect of breastfeeding against later obesity through cortisol in milk, which is a type of glucocorticoid. However, it does not mention hydrocortisone specifically nor does it discuss osteoarthritis. Hydrocortisone is one of several types of glucocorticoids, but the statement does not provide any information that would suggest a relationship between hydrocortisone and osteoarthritis." +10521296,Hydrocortisone related to eye disorder,369,"Conclusions and Relevance: Among adults with severe sepsis not in septic shock, use of hydrocortisone compared with placebo did not reduce the risk of septic shock within 14 days.",False,"'Does the phrase ""Hydrocortisone related to eye disorder"" receive at least indirect support from the statement: ""Conclusions and Relevance: Among adults with severe sepsis not in septic shock, use of hydrocortisone compared with placebo did not reduce the risk of septic shock within 14 days.""?","No, the statement does not provide indirect support for the phrase ""Hydrocortisone related to eye disorder"". The conclusion is about the use of hydrocortisone in adults with severe sepsis not in septic shock and its effect on reducing the risk of septic shock within 14 days. It does not mention nor imply any relation between hydrocortisone and eye disorders." +10518203,Hydrocortisone related to otitis externa,370,These findings suggest that HC may protect against hyperoxic injury in the developing pulmonary vasculature.,False,"'Does the phrase ""Hydrocortisone related to otitis externa"" receive at least indirect support from the statement: ""These findings suggest that HC may protect against hyperoxic injury in the developing pulmonary vasculature.""?","No, the statement ""These findings suggest that HC may protect against hyperoxic injury in the developing pulmonary vasculature"" does not provide indirect support for the phrase ""Hydrocortisone related to otitis externa."" - The connection between stressful life events, coping mechanisms, cortisol (a natural glucocorticoid), and HIV infection is complex. Increased cortisol levels due to stress can negatively impact immune function, potentially increasing susceptibility to HIV infection and disease progression. Coping mechanisms may mediate some of these effects by modulating cortisol levels and stress responses. However, these phenomena do not necessarily imply that prednisolone disrupts inflammation in" -27646185,Prednisolone prevents allergic disease,334,"Immunologic and hemodynamic effects of ""low-dose"" hydrocortisone in septic shock: a double-blind, randomized, placebo-controlled, crossover study.",False,"Is the triple 'Prednisolone prevents allergic disease' supported by the sentence: 'Immunologic and hemodynamic effects of ""low-dose"" hydrocortisone in septic shock: a double-blind, randomized, placebo-controlled, crossover study.'?","No, the statement does not provide indirect support for the phrase ""Prednisolone prevents allergic disease."" The study mentioned is about immunologic and hemodynamic effects of ""low-dose"" hydrocortisone in septic shock, which is different from Prednisolone and allergic disease. Prednisolone is a synthetic glucocorticoid used mainly for its anti-inflammatory effects while allergic disease is typically managed through antihistamines, decongestants, or immunotherapy. Although both Prednisolone and hydrocortisone belong to the glucocorticoid class, they have different therapeutic applications, and their effects on allergic diseases may not be generalized from one drug to another." -26227245,Prednisolone prevents synovitis,335,"To prolong the anti-tumor effect some mice were also given cyclophosphamide, hydrocortisone, or a second injection of virus.",False,"Is the triple 'Prednisolone prevents synovitis' supported by the sentence: 'To prolong the anti-tumor effect some mice were also given cyclophosphamide, hydrocortisone, or a second injection of virus.'?","No, the phrase ""Prednisolone prevents synovitis"" does not receive at least indirect support from the statement provided. The statement discusses an experiment involving mice that were given cyclophosphamide, hydrocortisone, or a second injection of virus in order to prolong the anti-tumor effect. However, prednisolone is not mentioned in this statement. In order for there to be indirect support for prednisolone preventing synovitis, there should be some connection made between prednisolone and either synovitis or another treatment for synovitis in the statement. Since no such connection is made in the statement provided, it does not offer indirect support for prednisolone preventing synovitis." -19453072,Prednisolone prevents hypereosinophilic syndrome,336,"In conclusion, HRT in postmenopausal asthmatic women has a favorable influence on the course of asthma, reduces daily use of glucocorticosteroids and frequency of asthma exacerbations and normalizes serum concentrations of estradiol, cortisol and DHEAS, which were decreased before HRT.",False,"Is the triple 'Prednisolone prevents hypereosinophilic syndrome' supported by the sentence: 'In conclusion, HRT in postmenopausal asthmatic women has a favorable influence on the course of asthma, reduces daily use of glucocorticosteroids and frequency of asthma exacerbations and normalizes serum concentrations of estradiol, cortisol and DHEAS, which were decreased before HRT.'?","No, the statement does not provide direct or indirect support for the claim that Prednisolone prevents hypereosinophilic syndrome. The statement discusses hormone replacement therapy (HRT) in postmenopausal asthmatic women and its effects on asthma course, glucocorticosteroid use, asthma exacerbations, and serum concentrations of estradiol, cortisol, and DHEAS. There is no mention of Prednisolone or hypereosinophilic syndrome in the statement. Therefore, it does not support the claim that Prednisolone prevents hypereosinophilic syndrome." -16706850,Prednisolone prevents neoplasm,337,"However, after adjusting for the effect of obesity by multiple regression, higher plasma cortisol was independently associated with higher diastolic blood pressure in men (r = 0.21, P = 0.04) but not in women, and higher fasting serum triglyceride levels in women (r = 0.28, P < 0. 001) but not in men.",False,"Is the triple 'Prednisolone prevents neoplasm' supported by the sentence: 'However, after adjusting for the effect of obesity by multiple regression, higher plasma cortisol was independently associated with higher diastolic blood pressure in men (r = 0.21, P = 0.04) but not in women, and higher fasting serum triglyceride levels in women (r = 0.28, P < 0. 001) but not in men.'?","No, the statement does not provide indirect support for the phrase ""Prednisolone prevents neoplasm."" The statement discusses the association between higher plasma cortisol levels and increased diastolic blood pressure in men as well as elevated fasting serum triglyceride levels in women. Prednisolone is a synthetic glucocorticoid used in treating various conditions such as inflammation; however, there is no mention or implication in the statement regarding its potential preventive effects on neoplasm (tumor formation). Therefore, it is inappropriate to infer any connection between Prednisolone and neoplasm prevention based on this statement alone." -15809068,Prednisolone prevents colitis,338,"ii) Reduction of cortisone to cortisol in the liver may increase insulin resistance in type 2 diabetes mellitus, and inhibition of the enzyme may lead to a decrease in gluconeogenesis.",False,"Is the triple 'Prednisolone prevents colitis' supported by the sentence: 'ii) Reduction of cortisone to cortisol in the liver may increase insulin resistance in type 2 diabetes mellitus, and inhibition of the enzyme may lead to a decrease in gluconeogenesis.'?","No, the statement does not provide indirect support for the phrase ""Prednisolone prevents colitis."" The provided information discusses how reducing cortisone to cortisol in the liver can impact insulin resistance in type 2 diabetes mellitus and inhibition of enzymes leading to decreased gluconeogenesis. Prednisolone is a synthetic glucocorticoid that acts on glucocorticoid receptors in various cells throughout the body; its primary mechanism is not related to preventing colitis. Although glucocorticoids like prednisolone can have anti-inflammatory effects that may potentially affect colitis symptoms in some contexts, the given statement does not provide any information that would suggest prednisolone prevents colitis." -11858005,Prednisolone prevents asthma,339,"Pretreatment of rats with hydrocortisone or protamin-Zn-insulin within 4 days altered in subsequent acute hypoxia (3 hrs, ""height"" 10 000 m) the isoenzyme spectrum of LDH in lungs, liver tissue and kidney cortex.",False,"Is the triple 'Prednisolone prevents asthma' supported by the sentence: 'Pretreatment of rats with hydrocortisone or protamin-Zn-insulin within 4 days altered in subsequent acute hypoxia (3 hrs, ""height"" 10 000 m) the isoenzyme spectrum of LDH in lungs, liver tissue and kidney cortex.'?","No, the statement does not provide indirect support for the phrase ""Prednisolone prevents asthma."" The statement discusses the effects of pretreatment with hydrocortisone or protamin-Zn-insulin on rats subjected to acute hypoxia. Prednisolone is neither mentioned nor implied in this statement. Furthermore, while hydrocortisone is a glucocorticoid like prednisolone, it is not the same compound, and their effects on asthma may not be identical. Additionally, changes in isoenzyme spectrums do not necessarily translate to prevention of asthma. Therefore, there is no clear connection between these two pieces of information." -10983909,Prednisolone prevents leprosy,340,Previously we related persistent cortisol increases to memory impairments in elderly humans studied over five years.,False,Is the triple 'Prednisolone prevents leprosy' supported by the sentence: 'Previously we related persistent cortisol increases to memory impairments in elderly humans studied over five years.'?,"No, the statement does not provide indirect support for the phrase ""Prednisolone prevents leprosy."" The initial statement discusses cortisol increases being related to memory impairments in elderly humans over five years. Prednisolone is a synthetic glucocorticoid used for its anti-inflammatory effects; it is not directly related to leprosy prevention. The connection between cortisol (a hormone naturally produced in the human body) and memory impairment does not imply that Prednisolone can prevent leprosy. + The statement in question discusses the potential protective effects of hydrocortisone (HC) against hyperoxic injury in the developing pulmonary vasculature. This is an entirely different context from otitis externa, which is an inflammation or infection of the outer ear canal. - However, it is worth noting that glucocorticoids like Prednisolone have been explored in leprosy treatment due to their anti-inflammatory properties. But simply because cortisol has some connection to memory impairments does not imply that Prednisolone prevents leprosy. The two statements operate in different contexts (memory impairment vs leprosy prevention) and involve different substances (cortisol vs Prednisolone). + The two statements discuss different aspects of hydrocortisone's potential effects, one in pulmonary vasculature and the other in the ear canal, without any overlap or connection between these two distinct areas of the body. Therefore, there is no implicit or explicit support for a relationship between hydrocortisone and otitis externa from the given statement." +10484611,Hydrocortisone related to ulcerative colitis,371,OBJECTIVE: Cortisol clearance is reduced in sepsis and may contribute to the development of impaired adrenocortical function that is thought to contribute to the pathophysiology of critical illness-related corticosteroid insufficiency.,False,"'Does the phrase ""Hydrocortisone related to ulcerative colitis"" receive at least indirect support from the statement: ""OBJECTIVE: Cortisol clearance is reduced in sepsis and may contribute to the development of impaired adrenocortical function that is thought to contribute to the pathophysiology of critical illness-related corticosteroid insufficiency.""?","No, the statement does not provide indirect support for the phrase ""Hydrocortisone related to ulcerative colitis."" The statement discusses cortisol clearance in sepsis and its potential contribution to impaired adrenocortical function in critical illness-related corticosteroid insufficiency. Hydrocortisone is a synthetic form of cortisol (a hormone naturally produced in the human body), but there is no mention of ulcerative colitis in the statement provided. Ulcerative colitis is a chronic inflammatory bowel disease, which may be treated using hydrocortisone as a therapeutic agent; however, that connection is not implied in the statement provided. To establish a connection between hydrocortisone and ulcerative colitis, additional information would be required that explicitly links these two concepts together." +9718673,Hydrocortisone related to atopic eczema,372,Hydrocortisone therapy was started to prevent adrenal insufficiency before laboratory findings for ACTH (adrenocorticotropic hormone) and cortisol levels.,False,"'Does the phrase ""Hydrocortisone related to atopic eczema"" receive at least indirect support from the statement: ""Hydrocortisone therapy was started to prevent adrenal insufficiency before laboratory findings for ACTH (adrenocorticotropic hormone) and cortisol levels.""?","No, the statement does not provide indirect support for the phrase ""Hydrocortisone related to atopic eczema."" The statement indicates that hydrocortisone therapy was initiated as a preventative measure for adrenal insufficiency based on laboratory results for ACTH (adrenocorticotropic hormone) and cortisol levels. The reason for initiating hydrocortisone therapy in this case is unrelated to atopic eczema. Therefore, there is no implicit or explicit connection between hydrocortisone use and atopic eczema in the provided statement." +9492934,Hydrocortisone related to opiate dependence,373,CONCLUSION: We conclude that intravenous stress doses of hydrocortisone lead to a reduction of systemic inflammation and to a potential improvement in the early outcome of patients undergoing off-pump CABG.,False,"'Does the phrase ""Hydrocortisone related to opiate dependence"" receive at least indirect support from the statement: ""CONCLUSION: We conclude that intravenous stress doses of hydrocortisone lead to a reduction of systemic inflammation and to a potential improvement in the early outcome of patients undergoing off-pump CABG.""?","No, the statement does not provide indirect support for the phrase ""Hydrocortisone related to opiate dependence."" The conclusion presented in the statement is about the effects of intravenous stress doses of hydrocortisone on systemic inflammation and early outcomes in patients undergoing off-pump coronary artery bypass grafting (CABG). It does not mention or imply any relationship between hydrocortisone and opiate dependence." +9238280,Hydrocortisone related to Sepsis,374,"CONCLUSION: In intubated trauma patients, the use of an intravenous stress-dose of hydrocortisone, compared with placebo, resulted in a decreased risk of hospital-acquired pneumonia.",False,"'Does the phrase ""Hydrocortisone related to Sepsis"" receive at least indirect support from the statement: ""CONCLUSION: In intubated trauma patients, the use of an intravenous stress-dose of hydrocortisone, compared with placebo, resulted in a decreased risk of hospital-acquired pneumonia.""?","No, the statement does not provide indirect support for the phrase ""Hydrocortisone related to Sepsis."" The conclusion in the statement indicates that hydrocortisone use in intubated trauma patients led to a decreased risk of hospital-acquired pneumonia compared to placebo. However, it does not mention or imply any connection between hydrocortisone and sepsis. Sepsis is a systemic inflammatory response syndrome due to infection, while hydrocortisone is primarily used as an anti-inflammatory and immunosuppressive agent in certain clinical situations, such as preventing adrenal insufficiency in septic shock patients. Although both sepsis and hydrocortisone use can be related in some contexts, this particular conclusion does not establish such a connection." +9235597,Hydrocortisone related to type 1 diabetes mellitus,375,"Early hydrocortisone (HC) treatment may decrease the incidence of bronchopulmonary dysplasia; however, the long-term effects are still under evaluation.",False,"'Does the phrase ""Hydrocortisone related to type 1 diabetes mellitus"" receive at least indirect support from the statement: ""Early hydrocortisone (HC) treatment may decrease the incidence of bronchopulmonary dysplasia; however, the long-term effects are still under evaluation.""?","No, the statement does not provide indirect support for the phrase ""Hydrocortisone related to type 1 diabetes mellitus."" - To establish indirect support for Prednisolone preventing leprosy based on these statements, there would need to be an explicit link between cortisol increases and leprosy" -10240036,Prednisolone prevents Inflammation,341,It was suggested that the progressive shift from type 1 to type 2 cytokine production characteristic of HIV infection could be at least partially provoked by the increase in the production of cortisol and the reduction of DHEA.,True,Is the triple 'Prednisolone prevents Inflammation' supported by the sentence: 'It was suggested that the progressive shift from type 1 to type 2 cytokine production characteristic of HIV infection could be at least partially provoked by the increase in the production of cortisol and the reduction of DHEA.'?,"Yes, there is indirect support for the phrase ""Prednisolone prevents Inflammation"" from the statement provided. + The statement discusses the use of hydrocortisone (HC) in relation to bronchopulmonary dysplasia, a chronic lung disease in premature infants. It does not mention or imply any connection between hydrocortisone and type 1 diabetes mellitus. Type 1 diabetes mellitus is an autoimmune disease where the body does not produce insulin, while hydrocortisone is a steroid hormone often used in treating various conditions due to its anti-inflammatory and immunosuppressive properties. Although hydrocortisone can have metabolic side effects that might theoretically impact diabetes risk, there is no direct evidence in the statement provided to suggest such a link. - - Prednisolone is a synthetic glucocorticoid hormone that acts as an anti-inflammatory and immunosuppressive agent. Glucocorticoids like Prednisolone work by binding to glucocorticoid receptors in cells throughout the body, inhibiting the production of pro-inflammatory cytokines like type 1 cytokines (e.g., interferon-gamma) while promoting the production of anti-inflammatory cytokines like type 2 cytokines (e.g., interleukin-4). + Therefore, it is crucial to evaluate scientific claims based on direct evidence pertaining to the specific claim in question. Extrapolating unrelated information may lead to misinterpretations or misunderstandings of the actual implications of the research." +8977987,Hydrocortisone related to injury,376,CONCLUSION: Intravenous hydrocortisone reduced the incidence of AF after cardiac surgery.,True,"'Does the phrase ""Hydrocortisone related to injury"" receive at least indirect support from the statement: ""CONCLUSION: Intravenous hydrocortisone reduced the incidence of AF after cardiac surgery.""?","Yes, there is indirect support for the phrase ""Hydrocortisone related to injury"" from the statement ""CONCLUSION: Intravenous hydrocortisone reduced the incidence of AF after cardiac surgery."" This is because hydrocortisone is being administered as an intervention to prevent atrial fibrillation (AF), which can be considered an injury in the context of cardiac surgery due to its potential negative impacts on patient outcomes. The statement implies that hydrocortisone has a protective effect against AF occurrence after cardiac surgery, suggesting that it may be beneficial in mitigating injury related to this procedure. However, it is essential to consider that direct evidence connecting hydrocortisone specifically to injury reduction is not explicitly provided in the statement; therefore, the support is indirect in nature." +8778414,Hydrocortisone related to Inflammation,377,"Assuming a single dose of hydrocortisone improves sensitivity of peripheral tissues to insulin, it may be an interesting candidate for use in reducing insulin resistance in peripheral tissues of horses with several disease states.",True,"'Does the phrase ""Hydrocortisone related to Inflammation"" receive at least indirect support from the statement: ""Assuming a single dose of hydrocortisone improves sensitivity of peripheral tissues to insulin, it may be an interesting candidate for use in reducing insulin resistance in peripheral tissues of horses with several disease states.""?","Yes, there is indirect support for the phrase ""Hydrocortisone related to Inflammation"" from the statement provided. - - The statement suggests that during HIV infection, there is an increase in cortisol production and a reduction in DHEA levels, which could lead to a shift from type 1 to type 2 cytokine production. Cortisol is another glucocorticoid hormone that shares some functional similarities with Prednisolone; however, it is naturally produced in the body and has more physi" -18452194,Prednisolone exacerbates ulcerative colitis,342,CONCLUSIONS: This study suggests that 24 h urinary free cortisol could be considered as a potential index of adrenal cortisol production in patients with liver cirrhosis and it potentially detects patients with a high mortality risk.,False,Is the triple 'Prednisolone exacerbates ulcerative colitis' supported by the sentence: 'CONCLUSIONS: This study suggests that 24 h urinary free cortisol could be considered as a potential index of adrenal cortisol production in patients with liver cirrhosis and it potentially detects patients with a high mortality risk.'?,"No, the statement does not provide indirect support for the phrase ""Prednisolone exacerbates ulcerative colitis."" The conclusion in the statement is about using 24-hour urinary free cortisol as an index for adrenal cortisol production in patients with liver cirrhosis and its potential association with mortality risk. It does not mention prednisolone or ulcerative colitis. Prednisolone is a synthetic glucocorticoid used primarily for its anti-inflammatory properties in various conditions such as asthma, rheumatoid arthritis, and inflammatory bowel diseases like ulcerative colitis; however, its specific impact on ulcerative colitis exacerbation would need separate evidence for evaluation." -25753407,Prednisolone predisposes neoplasm,343,Congenital adrenal hyperplasia (CAH) is an autosomal recessive disorder that leads to the partial or complete deficiency of cortisol and aldosterone production from the adrenal glands.,False,Is the triple 'Prednisolone predisposes neoplasm' supported by the sentence: 'Congenital adrenal hyperplasia (CAH) is an autosomal recessive disorder that leads to the partial or complete deficiency of cortisol and aldosterone production from the adrenal glands.'?,"No, the statement ""Congenital adrenal hyperplasia (CAH) is an autosomal recessive disorder that leads to the partial or complete deficiency of cortisol and aldosterone production from the adrenal glands"" does not provide indirect support for the phrase ""Prednisolone predisposes neoplasm."" + The statement suggests that hydrocortisone could improve sensitivity of peripheral tissues to insulin, which may help reduce insulin resistance in horses with various disease states. This is relevant because insulin resistance is often associated with chronic low-grade inflammation in horses as well as in humans. - Prednisolone is a synthetic glucocorticoid hormone used in various medical treatments, including for inflammatory conditions and as a replacement therapy in adrenal insufficiency disorders like CAH. While it is true that people with CAH may be prescribed Prednisolone, there is no direct link established between Prednisolone use and an increased predisposition to neoplasm (abnormal tissue growth that can lead to cancer) based on the information provided. + Hydrocortisone is a glucocorticoid hormone known for its potent anti-inflammatory effects due to its ability to suppress cytokine production and immune cell activity. Thus, by improving insulin sensitivity in peripheral tissues, hydrocortisone might indirectly help reduce inflammation in horses with certain disease states. - The development of neoplasms is influenced by various factors such as genetics, environment, lifestyle, and other medical conditions. While some studies suggest that prolonged glucocorticoid use might be associated with an increased risk for certain types of cancer, it is crucial to differentiate between correlation and causation in such cases." -16546227,Prednisolone predisposes pneumonia,344,[Reaction of autogenous cortisol production in patients with extensive psoriasis vulgaris or atopic dermatitis following external administration of a 0.25% prednicarbate salve (W/O emulsion)].,False,Is the triple 'Prednisolone predisposes pneumonia' supported by the sentence: '[Reaction of autogenous cortisol production in patients with extensive psoriasis vulgaris or atopic dermatitis following external administration of a 0.25% prednicarbate salve (W/O emulsion)].'?,"No, the statement does not provide indirect support for the phrase ""Prednisolone predisposes pneumonia."" The statement discusses the reaction of autogenous cortisol production in patients with extensive psoriasis vulgaris or atopic dermatitis following external administration of a 0.25% prednicarbate salve (W/O emulsion). Prednisolone is not mentioned in this statement; therefore, it cannot provide any evidence for or against its potential to predispose pneumonia. Prednisolone is a synthetic glucocorticoid often used in treating various inflammatory diseases; however, its potential link to pneumonia would require separate investigation and evidence." -27027571,Hydrocortisone related to HIV infectious disease,345,"OBJECTIVE: Corticosteroid-binding globulin (CBG), the cortisol transport protein, is cleaved from high-affinity (haCBG) to low-affinity (laCBG) CBG at sites of inflammation releasing bioavailable, anti-inflammatory cortisol.",False,"Is the triple 'Hydrocortisone related to HIV infectious disease' supported by the sentence: 'OBJECTIVE: Corticosteroid-binding globulin (CBG), the cortisol transport protein, is cleaved from high-affinity (haCBG) to low-affinity (laCBG) CBG at sites of inflammation releasing bioavailable, anti-inflammatory cortisol.'?","No, the statement does not provide direct or indirect support for the phrase ""Hydrocortisone related to HIV infectious disease."" The statement discusses corticosteroid-binding globulin (CBG) and its role in releasing bioavailable cortisol at sites of inflammation; however, it does not mention hydrocortisone nor HIV infectious disease. Hydrocortisone is a type of corticosteroid that can bind to CBG; therefore, understanding CBG behavior might have implications for hydrocortisone usage in certain contexts. However, without explicit reference to hydrocortisone or HIV in the statement, there is no specific support for that phrase." -25927636,Hydrocortisone related to cardiac arrest,346,The propensity to develop type 1 diabetes or type 2 diabetes/metabolic syndrome depends on the propensity to release of cortisol which correlates with race.,False,Is the triple 'Hydrocortisone related to cardiac arrest' supported by the sentence: 'The propensity to develop type 1 diabetes or type 2 diabetes/metabolic syndrome depends on the propensity to release of cortisol which correlates with race.'?,"No, the statement does not provide indirect support for the phrase ""Hydrocortisone related to cardiac arrest."" The initial statement discusses how race may influence the propensity for releasing cortisol, which in turn affects the likelihood of developing certain types of diabetes or metabolic syndrome. Hydrocortisone is synthetic cortisol; however, there is no direct link established between cortisol release influenced by race and cardiac arrest in either statement. While it is true that high levels of cortisol can contribute to various health issues such as diabetes, hypertension, and osteoporosis, it does not automatically imply that hydrocortisone usage would be associated with cardiac arrest. Further investigation is required to establish such a link conclusively." -25797574,Hydrocortisone related to lymphoma,347,"CIRCI is characterized by an inadequate production of cortisol in relation to an increased demand during periods of severe stress, particularly in critical illnesses such as sepsis or septic shock.",False,"Is the triple 'Hydrocortisone related to lymphoma' supported by the sentence: 'CIRCI is characterized by an inadequate production of cortisol in relation to an increased demand during periods of severe stress, particularly in critical illnesses such as sepsis or septic shock.'?","No, the statement does not provide direct or indirect support for the phrase ""Hydrocortisone related to lymphoma."" The statement discusses CIRCI (Critical Illness-Related Corticosteroid Insufficiency), which is characterized by inadequate cortisol production in response to severe stress in conditions like sepsis or septic shock. Hydrocortisone is a synthetic glucocorticoid often used as replacement therapy in CIRCI patients. Although lymphoma is a type of cancer that can be associated with immune system dysfunction, no link is established between hydrocortisone use in CIRCI patients and lymphoma in the given statement." -25131277,Hydrocortisone related to Crohn disease,348,Synacthen test diagnosed Addison's disease with a clear deficiency of cortisol production.,False,Is the triple 'Hydrocortisone related to Crohn disease' supported by the sentence: 'Synacthen test diagnosed Addison's disease with a clear deficiency of cortisol production.'?,"No, the statement ""Synacthen test diagnosed Addison's disease with a clear deficiency of cortisol production"" does not provide indirect support for the phrase ""Hydrocortisone related to Crohn disease"". + However, it is essential to acknowledge that hydrocortisone also has immunosuppressive properties that could potentially exacerbate existing infections in horses suffering from inflammatory conditions. Therefore, further studies would be required to evaluate hydrocortisone's overall impact on inflammation in horses and any potential risks associated with its administration in horses with" +8763179,Hydrocortisone related to toxic shock syndrome,378,Plasma cortisol and glucagon concentrations were not increased markedly except in a case complicated other systemic bacterial infection.,False,"'Does the phrase ""Hydrocortisone related to toxic shock syndrome"" receive at least indirect support from the statement: ""Plasma cortisol and glucagon concentrations were not increased markedly except in a case complicated other systemic bacterial infection.""?","No, the phrase ""Hydrocortisone related to toxic shock syndrome"" does not receive indirect support from the statement provided. The statement discusses plasma cortisol concentrations in relation to bacterial infection but does not mention hydrocortisone or toxic shock syndrome directly. Hydrocortisone is a synthetic form of cortisol, a hormone that the body naturally produces in response to stress; it is not typically associated with toxic shock syndrome (TSS). TSS is primarily caused by certain types of bacteria producing exotoxins that trigger an overwhelming immune response leading to shock-like symptoms, not by cortisol or its synthetic forms like hydrocortisone. Therefore, there is no indirect support for any relationship between hydrocortisone and TSS based on the statement given." +8625521,Hydrocortisone related to dissociative amnesia,379,"In view of the stimulatory effects of insulin and cortisol on adipogenesis, long-term stimulation of 11betaHSD reductase activity by insulin could aggravate visceral obesity.",False,"'Does the phrase ""Hydrocortisone related to dissociative amnesia"" receive at least indirect support from the statement: ""In view of the stimulatory effects of insulin and cortisol on adipogenesis, long-term stimulation of 11betaHSD reductase activity by insulin could aggravate visceral obesity.""?","No, the statement does not provide indirect support for the phrase ""Hydrocortisone related to dissociative amnesia."" The statement discusses the relationship between insulin, cortisol (which is related to hydrocortisone), and adipogenesis (the formation of fat cells), but it does not mention or imply any connection to dissociative amnesia. Dissociative amnesia is a condition related to memory loss, not obesity or adipogenesis. Therefore, while there may be a connection between hydrocortisone (a synthetic form of cortisol) and adipogenesis as suggested by the statement, there is no connection established between hydrocortisone and dissociative amnesia in this context." +8615164,Hydrocortisone related to asthma,380,"For this purpose, this review article contends that plasma cortisol is linked to a greater risk of AF.",False,"'Does the phrase ""Hydrocortisone related to asthma"" receive at least indirect support from the statement: ""For this purpose, this review article contends that plasma cortisol is linked to a greater risk of AF.""?","No, the statement does not provide indirect support for the phrase ""Hydrocortisone related to asthma"". The review article discusses plasma cortisol's link to an increased risk of atrial fibrillation (AF), not asthma. Hydrocortisone is a synthetic glucocorticoid hormone that mimics the actions of cortisol in the body; however, cortisol is not exclusively produced in response to asthma attacks but is part of the body's general stress response. Therefore, it is crucial to consider the context of any statement when interpreting its relevance to specific scientific questions." +8570630,Hydrocortisone related to fibromyalgia,381,"After multivariate analysis, duration of HC stress dose administration was associated with increased risk of mortality (OR 1.11, 95% CI 1.02-1.2, p = 0.021), and total duration of HC treatment was associated with increased risk of sepsis (OR 1.04, 95% CI 1.005-1.075, p = 0.026).",False,"'Does the phrase ""Hydrocortisone related to fibromyalgia"" receive at least indirect support from the statement: ""After multivariate analysis, duration of HC stress dose administration was associated with increased risk of mortality (OR 1.11, 95% CI 1.02-1.2, p = 0.021), and total duration of HC treatment was associated with increased risk of sepsis (OR 1.04, 95% CI 1.005-1.075, p = 0.026).""?","No, the statement does not provide direct or indirect support for the phrase ""Hydrocortisone related to fibromyalgia"". The statement discusses the association of hydrocortisone (HC) stress dose administration duration with increased risk of mortality, and total duration of HC treatment associated with increased risk of sepsis in a general context. However, it does not mention or imply any connection between hydrocortisone and fibromyalgia." +8017438,Hydrocortisone related to Insulin resistance,382,"Plasma leptin and ghrelin levels in endotoxin-treated dogs were correlated with serum nitric oxide (r = .955 and r = .890; p < .001), procalcitonin (r = .825 and r = .716; p < .001), cortisol (r = .823 and r = .786; p < .001), and hepatorenal injury markers (r = .580 to .745 and r = .393 to .574; p < .05 to .01).",False,"'Does the phrase ""Hydrocortisone related to Insulin resistance"" receive at least indirect support from the statement: ""Plasma leptin and ghrelin levels in endotoxin-treated dogs were correlated with serum nitric oxide (r = .955 and r = .890; p < .001), procalcitonin (r = .825 and r = .716; p < .001), cortisol (r = .823 and r = .786; p < .001), and hepatorenal injury markers (r = .580 to .745 and r = .393 to .574; p < .05 to .01).""?","No, the statement does not provide direct support for the phrase ""Hydrocortisone related to Insulin resistance"". The statement discusses correlations between various factors in endotoxin-treated dogs, including cortisol (which is related to hydrocortisone), but it does not mention insulin resistance or provide any information about how hydrocortisone might be related to insulin resistance. - The Synacthen test is used to diagnose conditions related to cortisol deficiency, such as Addison's disease. Hydrocortisone is a synthetic form of cortisol, a hormone that the body naturally produces in response to stress. It is commonly used to treat conditions associated with cortisol deficiency, such as Addison's disease. + However, it is important to note that cortisol is a glucocorticoid hormone like hydrocortisone, and both can influence metabolic processes including insulin sensitivity. Prolonged exposure to high levels of these hormones can lead to insulin resistance in some individuals. But this statement does not provide direct evidence for that relationship. - However, Crohn's disease is an inflammatory bowel disease that is not primarily characterized by cortisol deficiency. While corticosteroids like hydrocortisone can be used to manage inflammation in Crohn's disease, this does not imply a direct relationship between hydrocortisone and Crohn's disease. The statement about the Synacthen test diagnosing Addison's disease does not provide any information about hydrocortisone use in Crohn's disease, therefore it does not offer indirect support for the stated phrase." -19793698,Hydrocortisone related to alcohol abuse,349,"Enhanced cortisol production rates, free cortisol, and 11beta-HSD-1 expression correlate with visceral fat and insulin resistance in men: effect of weight loss.",False,"Is the triple 'Hydrocortisone related to alcohol abuse' supported by the sentence: 'Enhanced cortisol production rates, free cortisol, and 11beta-HSD-1 expression correlate with visceral fat and insulin resistance in men: effect of weight loss.'?","No, the statement does not provide direct or indirect support for the phrase ""Hydrocortisone related to alcohol abuse."" The statement discusses cortisol production rates, free cortisol, and 11beta-HSD-1 expression in relation to visceral fat and insulin resistance in men, and how these factors change in response to weight loss. Hydrocortisone is a synthetic glucocorticoid often used as a medication and is not mentioned in the statement. Additionally, alcohol abuse is not mentioned in the statement either. Therefore, there is no connection that can be drawn between hydrocortisone and alcohol abuse from this statement." -19531872,Hydrocortisone related to atrial fibrillation,350,"Obesity is also related to dysregulation of cortisol production by the pre-receptor enzyme, 11beta-hydroxysteroid dehydrogenase, and we speculate that this may have a role in the pathogenesis of obesity and raised ICP seen in IIH.",False,"Is the triple 'Hydrocortisone related to atrial fibrillation' supported by the sentence: 'Obesity is also related to dysregulation of cortisol production by the pre-receptor enzyme, 11beta-hydroxysteroid dehydrogenase, and we speculate that this may have a role in the pathogenesis of obesity and raised ICP seen in IIH.'?","No, the statement does not provide direct or indirect support for the phrase ""Hydrocortisone related to atrial fibrillation."" The statement discusses obesity being related to dysregulation of cortisol production by the enzyme 11beta-hydroxysteroid dehydrogenase, which may contribute to pathogenesis in obesity and idiopathic intracranial hypertension (IIH). Hydrocortisone is a synthetic form of cortisol; however, there is no mention in the statement linking cortisol dysregulation specifically to hydrocortisone use or atrial fibrillation. + Therefore, while there is indirect theoretical support for a relationship between hydrocortisone and insulin resistance based on our general understanding of these hormones, this specific statement does not provide direct evidence for that relationship." +7919367,Hydrocortisone related to adrenocortical insufficiency,383,Contribution of cortisol deficiency to septic shock.,True,"'Does the phrase ""Hydrocortisone related to adrenocortical insufficiency"" receive at least indirect support from the statement: ""Contribution of cortisol deficiency to septic shock.""?","Yes, indirectly it does. The statement ""Contribution of cortisol deficiency to septic shock"" implies that there is a relationship between cortisol levels and adrenocortical insufficiency (a condition characterized by insufficient production of cortisol), as hydrocortisone is a synthetic form of cortisol. Therefore, if cortisol deficiency contributes to septic shock, then managing adrenocortical insufficiency with hydrocortisone could be beneficial in preventing or treating septic shock symptoms. However, it is important to note that further investigation would be required to establish a direct causal relationship between hydrocortisone use and adrenocortical insufficiency prevention/treatment in septic shock cases specifically." +7573954,Hydrocortisone related to neoplasm,384,The objective of this study was to demonstrate the effect of stress doses of hydrocortisone during the initial phase of human septic shock on the serum values of the neurospecific protein S-100B in comparison to the inflammation markers interleukin (IL)-8 in serum and polymorphonuclear (PMN) elastase in plasma.,False,"'Does the phrase ""Hydrocortisone related to neoplasm"" receive at least indirect support from the statement: ""The objective of this study was to demonstrate the effect of stress doses of hydrocortisone during the initial phase of human septic shock on the serum values of the neurospecific protein S-100B in comparison to the inflammation markers interleukin (IL)-8 in serum and polymorphonuclear (PMN) elastase in plasma.""?","No, the statement does not provide indirect support for the phrase ""Hydrocortisone related to neoplasm"". The objective of the study as stated is focused on examining the impact of stress doses of hydrocortisone on serum values of certain proteins and inflammation markers in human septic shock patients. There is no mention of neoplasm (abnormal tissue growth that may become cancerous) in the statement. Therefore, it does not provide any relevant information or evidence regarding a relationship between hydrocortisone and neoplasm." +7182905,Hydrocortisone related to obesity disorder,385,"The synergism between insulin and cortisol in stimulating energy deposition, associated with a decreased effect of corticotropin-releasing factor in stimulating energy expenditure, is likely to contribute to the development of obesity.",True,"'Does the phrase ""Hydrocortisone related to obesity disorder"" receive at least indirect support from the statement: ""The synergism between insulin and cortisol in stimulating energy deposition, associated with a decreased effect of corticotropin-releasing factor in stimulating energy expenditure, is likely to contribute to the development of obesity.""?","Yes, the statement does provide indirect support for the connection between hydrocortisone (a type of cortisol) and obesity disorder. The statement suggests that cortisol, in conjunction with insulin, plays a significant role in stimulating energy deposition while decreasing the effect of corticotropin-releasing factor in stimulating energy expenditure. This imbalance can contribute to obesity development. - The nuances here involve understanding that cortisol is a steroid hormone produced by the adrenal gland in response to stress, while hydrocortisone is a medication used in various medical contexts. The statement focuses on obesity-related cortisol dysregulation in IIH pathogenesis but does not provide any evidence connecting hydrocortisone use to atrial fibrillation risk. + Hydrocortisone is a glucocorticoid hormone that shares many functions with cortisol; they can be used interchangeably in some contexts. Obesity has been linked to excessive glucocorticoid exposure, such as that caused by Cushing syndrome (a condition characterized by high levels of cortisol). Thus, it is plausible that exposure to hydrocortisone could also contribute to obesity development due to its similarity in function to cortisol. - In conclusion, while cortisol dysregulation may have various implications in human" -18705900,Hydrocortisone related to phobic disorder,351,"This is an extremely rare case of bilateral adrenal tumors, in which the left adrenocortical tumor produced and secreted cortisol or both cortisol and aldosterone and the right one produced and secreted both aldosterone and cortisol, as confirmed by clinical findings and pathological studies using immunohistochemical analysis.",False,"Is the triple 'Hydrocortisone related to phobic disorder' supported by the sentence: 'This is an extremely rare case of bilateral adrenal tumors, in which the left adrenocortical tumor produced and secreted cortisol or both cortisol and aldosterone and the right one produced and secreted both aldosterone and cortisol, as confirmed by clinical findings and pathological studies using immunohistochemical analysis.'?","No, the statement does not provide direct or indirect support for the phrase ""Hydrocortisone related to phobic disorder"". The statement discusses an extremely rare case of bilateral adrenal tumors that produce and secrete cortisol and aldosterone; however, it does not mention anything about hydrocortisone being related to phobic disorder. Hydrocortisone is a synthetic version of cortisol, which is produced naturally in the body by the adrenal glands; therefore, it is not necessarily related to phobic disorders unless explicitly stated in further evidence." -15155784,Hydrocortisone related to psoriasis,352,"We conclude that the clinical picture of late-onset adrenal insufficiency in preterm infants is not a result of an absolute deficiency of cortisol production, but may be a result of a limited ability to synthesize sufficient cortisol for the degree of clinical stress.",False,"Is the triple 'Hydrocortisone related to psoriasis' supported by the sentence: 'We conclude that the clinical picture of late-onset adrenal insufficiency in preterm infants is not a result of an absolute deficiency of cortisol production, but may be a result of a limited ability to synthesize sufficient cortisol for the degree of clinical stress.'?","No, the statement does not provide indirect support for the phrase ""Hydrocortisone related to psoriasis"". The statement discusses late-onset adrenal insufficiency in preterm infants and its potential connection to cortisol production. Hydrocortisone is a synthetic form of cortisol, but the connection between hydrocortisone and psoriasis is unrelated to adrenal insufficiency in preterm infants. Psoriasis is an immune-mediated skin condition that has been treated with hydrocortisone, but the statement does not provide any evidence or reasoning that would link hydrocortisone use to psoriasis treatment." -14891361,"Hydrocortisone related to dermatitis, atopic",353,"Ironically, despite our understanding of the various stressors that promote chronic adult-onset asthma, most of which are known to elevate cortisol production via the hypothalamic-pituitary-adrenal (HPA) axis, inhaled and systemic corticosteroids are the mainstay for the treatment of chronic asthma.",False,"Is the triple 'Hydrocortisone related to dermatitis, atopic' supported by the sentence: 'Ironically, despite our understanding of the various stressors that promote chronic adult-onset asthma, most of which are known to elevate cortisol production via the hypothalamic-pituitary-adrenal (HPA) axis, inhaled and systemic corticosteroids are the mainstay for the treatment of chronic asthma.'?","No, the statement does not provide indirect support for the phrase ""Hydrocortisone related to dermatitis, atopic."" The statement discusses the use of corticosteroids in treating chronic asthma, but it does not mention hydrocortisone specifically, nor does it link corticosteroids to dermatitis or atopic dermatitis. Hydrocortisone is a type of corticosteroid often used in treating various skin conditions such as dermatitis; however, this connection is not made in the provided statement. Therefore, without additional context or evidence linking hydrocortisone to atopic dermatitis, one cannot infer support for that phrase based on the statement alone." -14483328,Hydrocortisone related to bronchopulmonary dysplasia,354,Glucocorticoid insufficiency is common during sepsis and may result from insufficient production of cortisol or peripheral tissues resistance.,False,Is the triple 'Hydrocortisone related to bronchopulmonary dysplasia' supported by the sentence: 'Glucocorticoid insufficiency is common during sepsis and may result from insufficient production of cortisol or peripheral tissues resistance.'?,"No, the statement does not provide direct or indirect support for the phrase ""Hydrocortisone related to bronchopulmonary dysplasia."" The statement discusses glucocorticoid insufficiency during sepsis, which can be due to inadequate cortisol production or peripheral tissue resistance. Hydrocortisone is a type of glucocorticoid often used as a replacement therapy in cases of insufficiency; however, the statement does not establish any connection between glucocorticoid insufficiency (or its related treatments) and bronchopulmonary dysplasia. Bronchopulmonary dysplasia is a chronic lung disease in premature infants, and while glucocorticoids like hydrocortisone have been studied in its treatment, that relationship is not implied in the given statement." -14450267,Hydrocortisone related to adrenal cortex neoplasm,355,"This likely represents an adaptive response to LTH, to prevent excessive cortisol production that would restrict fetal growth and potentially induce preterm delivery.",False,"Is the triple 'Hydrocortisone related to adrenal cortex neoplasm' supported by the sentence: 'This likely represents an adaptive response to LTH, to prevent excessive cortisol production that would restrict fetal growth and potentially induce preterm delivery.'?","No, the statement does not provide indirect support for the phrase ""Hydrocortisone related to adrenal cortex neoplasm"". The provided statement discusses an adaptive response related to cortisol production in relation to long-term hypoxia (LTH), which is unrelated to hydrocortisone or adrenal cortex neoplasm (a type of tumor). Hydrocortisone is a synthetic form of cortisol, a hormone produced by the adrenal gland, but there is no connection made between these elements in either statement." -14387016,Hydrocortisone related to cirrhosis of liver,356,"The reduction in local cortisol production which diminishes the endogenous anti-inflammatory effects, also allows for the progression of both vascular and pulmonary inflammation.",False,"Is the triple 'Hydrocortisone related to cirrhosis of liver' supported by the sentence: 'The reduction in local cortisol production which diminishes the endogenous anti-inflammatory effects, also allows for the progression of both vascular and pulmonary inflammation.'?","No, the statement does not provide direct or indirect support for the phrase ""Hydrocortisone related to cirrhosis of liver."" The provided statement discusses the relationship between cortisol production and inflammation but does not mention hydrocortisone or cirrhosis of the liver. Hydrocortisone is a synthetic version of cortisol, but no connection is made in this statement between hydrocortisone and liver cirrhosis. To establish support for such a claim, additional evidence would be needed that links hydrocortisone use specifically to liver cirrhosis progression." -14360687,Hydrocortisone related to dermatitis,357,"CONCLUSIONS: Patients with newly diagnosed, untreated PC yielded significantly higher cortisol and lower estradiol serum concentrations than controls.",False,"Is the triple 'Hydrocortisone related to dermatitis' supported by the sentence: 'CONCLUSIONS: Patients with newly diagnosed, untreated PC yielded significantly higher cortisol and lower estradiol serum concentrations than controls.'?","No, the statement does not provide direct or indirect support for the phrase ""Hydrocortisone related to dermatitis."" The conclusion in the statement refers to cortisol serum concentrations in patients with prostate cancer (PC) compared to controls, but it does not mention hydrocortisone or dermatitis. Hydrocortisone is a synthetic glucocorticoid hormone used primarily for its anti-inflammatory effects in various conditions such as dermatitis; however, no such connection is made in the provided statement." -13844584,Hydrocortisone related to acute myeloid leukemia,358,"The tumour secreted excessive cortisol and dehydroepiandrosterone-sulphate (DHEA-S), and had invaded the right hepatic lobe and vena cava.",False,"Is the triple 'Hydrocortisone related to acute myeloid leukemia' supported by the sentence: 'The tumour secreted excessive cortisol and dehydroepiandrosterone-sulphate (DHEA-S), and had invaded the right hepatic lobe and vena cava.'?","No, the statement does not provide direct or indirect support for the phrase ""Hydrocortisone related to acute myeloid leukemia"". + However, it is essential to acknowledge that further investigation is necessary for establishing direct causality between hydrocortisone exposure and obesity disorder since numerous factors influence obesity development, including genetics, lifestyle choices, mental health conditions, and other environmental" +24445107,Hydrocortisone related to Inflammation,386,Higher basal cortisol predicts verbal memory loss in postmenopausal women: Rancho Bernardo Study.,True,"'Does the phrase ""Hydrocortisone related to Inflammation"" receive at least indirect support from the statement: ""Higher basal cortisol predicts verbal memory loss in postmenopausal women: Rancho Bernardo Study.""?","Yes, there is indirect support for the phrase ""Hydrocortisone related to Inflammation"" from the statement ""Higher basal cortisol predicts verbal memory loss in postmenopausal women: Rancho Bernardo Study."" - The statement discusses a tumour that secretes excessive cortisol and DHEA-S, and has invaded certain liver structures. Hydrocortisone is a synthetic form of cortisol, a hormone that the body naturally produces in response to stress. DHEA-S is a hormone synthesized from DHEA (dehydroepiandrosterone), which is produced from cholesterol by the adrenal glands; it functions as a precursor to other hormones like testosterone and estrogen. + The key connection lies in understanding that hydrocortisone is a type of cortisol hormone naturally produced in the human body by the adrenal glands. Cortisol is known for its involvement in the body's response to stress, regulating metabolism, and reducing inflammation. - Although cortisol and DHEA-S are related to hydrocortisone in terms of their physiological roles and synthesis pathways, no evidence is presented in the statement that connects hydrocortisone specifically to acute myeloid leukemia (AML). AML is a type of cancer that affects the bone marrow's production of blood cells; it is not necessarily linked to cortisol or hydrocortisone levels in" -13213365,Hydrocortisone related to chronic primary adrenal insufficiency,359,Replacement doses of hydrocortisone were administered throughout treatment to counteract potential adrenal insufficiency secondary to the ketoconazole.,True,Is the triple 'Hydrocortisone related to chronic primary adrenal insufficiency' supported by the sentence: 'Replacement doses of hydrocortisone were administered throughout treatment to counteract potential adrenal insufficiency secondary to the ketoconazole.'?,"Yes, indirect support can be inferred from the statement provided. The use of hydrocortisone in treating potential adrenal insufficiency secondary to ketoconazole does suggest a relationship between hydrocortisone and adrenal insufficiency. However, it does not specifically mention chronic primary adrenal insufficiency. + The Rancho Bernardo Study indicates that higher basal cortisol levels predict verbal memory loss in postmenopausal women. Although this study does not explicitly mention hydrocortisone, it still provides indirect evidence for a relationship between cortisol (including hydrocortisone) and inflammation since elevated cortisol levels can be linked to chronic inflammation. - The statement indicates that hydrocortisone was used as a replacement therapy to counteract adrenal insufficiency that was secondary to ketoconazole treatment. This implies that hydrocortisone has a role in managing adrenal insufficiency, which is a characteristic feature of chronic primary adrenal insufficiency. Therefore, while the statement does not explicitly mention chronic primary adrenal insufficiency, it does provide indirect support for the association between hydrocortisone and adrenal insufficiency. + Chronic inflammation is associated with various health issues, including impaired cognitive function and memory loss. Therefore, it is plausible that hydrocortisone could influence inflammation based on the Ran" +24030854,Hydrocortisone related to Hypoxemia,387,"A growing body of evidence now suggests that endogenous cortisol, which is produced in significant quantities by the body in a diurnal rhythm, is an important regulator of allergic disease expression and allergic inflammatory responses: lung function varies along with plasma cortisol levels; the number of circulating inflammatory cells varies with plasma cortisol levels; and low levels of endogenous cortisol may be associated with risk for asthma.",True,"'Does the phrase ""Hydrocortisone related to Hypoxemia"" receive at least indirect support from the statement: ""A growing body of evidence now suggests that endogenous cortisol, which is produced in significant quantities by the body in a diurnal rhythm, is an important regulator of allergic disease expression and allergic inflammatory responses: lung function varies along with plasma cortisol levels; the number of circulating inflammatory cells varies with plasma cortisol levels; and low levels of endogenous cortisol may be associated with risk for asthma.""?","Yes, there is indirect support for the statement ""Hydrocortisone related to Hypoxemia"" from the provided evidence. Hydrocortisone is a synthetic form of cortisol, a hormone that the body naturally produces in response to stress. The statement suggests that endogenous cortisol plays a significant role in regulating allergic disease expression and inflammatory responses, particularly in lung function and circulating inflammatory cells. - It is important to note that adrenal insufficiency can be secondary to various causes, including diseases or medications like ketoconazole that affect adrenal function. Chronic primary adrenal insufficiency, on the other hand, is caused by intrinsic dysfunction or damage to the adrenal glands" -12756660,Hydrocortisone related to borderline personality disorder,360,Amplication by hydrocortisone of the induction of cytotoxic response in vitro to syngeneic murine leukemias.,False,Is the triple 'Hydrocortisone related to borderline personality disorder' supported by the sentence: 'Amplication by hydrocortisone of the induction of cytotoxic response in vitro to syngeneic murine leukemias.'?,"No, the statement ""Amplication by hydrocortisone of the induction of cytotoxic response in vitro to syngeneic murine leukemias"" does not provide indirect support for the phrase ""Hydrocortisone related to borderline personality disorder."" + Hypoxemia is a condition characterized by low levels of oxygen in the blood. Cortisol, including synthetic forms like hydrocortisone, has anti-inflammatory effects that could potentially impact lung function and inflammatory cell counts, both of which could be relevant to hypoxemia. However, it is important to note that while there is indirect support for a relationship between hydrocortisone and hypoxemia based on these mechanisms, direct evidence of such a relationship is not provided in the statement. - The statement discusses hydrocortisone's role in amplifying cytotoxic responses in vitro (in a lab setting) to syngeneic murine leukemias (mouse leukemias). This is a far cry from making any connection between hydrocortisone and borderline personality disorder (BPD), which is a complex mental health condition affecting human behavior and emotion regulation. + Therefore, while it is plausible that hydrocortisone could be related to hypoxemia through its effects on lung function and inflammatory cells, further research would be needed to" +12533519,Hydrocortisone related to Insulin resistance,388,"In conclusion, the data presented here suggest that cortisol can contribute to insulin resistance in ponies with hyperlipoproteinaemia.",True,"'Does the phrase ""Hydrocortisone related to Insulin resistance"" receive at least indirect support from the statement: ""In conclusion, the data presented here suggest that cortisol can contribute to insulin resistance in ponies with hyperlipoproteinaemia.""?","Yes, there is indirect support for the phrase ""Hydrocortisone related to Insulin resistance"" from the statement provided. Hydrocortisone is a synthetic form of cortisol, a hormone that the body naturally produces in response to stress. The statement suggests that cortisol can contribute to insulin resistance in ponies with hyperlipoproteinaemia. Given that hydrocortisone is a synthetic form of cortisol, it stands to reason that hydrocortisone could also contribute to insulin resistance under similar circumstances. However, it is important to note that direct experimental evidence is not provided in the statement; therefore, any connection made between hydrocortisone and insulin resistance remains indirect at this point." +27747116,Hydrocortisone causes toxic shock syndrome,389,"OBJECTIVE: To investigate the relationship of cortisol concentrations during the first week of life to patent ductus arteriosus (PDA), markers of lung inflammation, and respiratory outcome in very low birth weight infants.",False,"'Does the phrase ""Hydrocortisone causes toxic shock syndrome"" receive at least indirect support from the statement: ""OBJECTIVE: To investigate the relationship of cortisol concentrations during the first week of life to patent ductus arteriosus (PDA), markers of lung inflammation, and respiratory outcome in very low birth weight infants.""?","No, the statement does not provide indirect support for the phrase ""Hydrocortisone causes toxic shock syndrome."" The objective of the study is to investigate the relationship between cortisol concentrations during the first week of life (note that it does not specify hydrocortisone administration), PDA, markers of lung inflammation, and respiratory outcome in very low birth weight infants. Toxic shock syndrome is an acute illness characterized by fever, shock, and organ failure caused by certain types of bacteria that produce exotoxins; it is not explicitly linked to hydrocortisone use in the study objective provided." +27747115,Hydrocortisone causes Sepsis,390,Oral pH-modified release budesonide versus 6-methylprednisolone in active Crohn's disease.,False,"'Does the phrase ""Hydrocortisone causes Sepsis"" receive at least indirect support from the statement: ""Oral pH-modified release budesonide versus 6-methylprednisolone in active Crohn's disease.""?","No, the statement ""Oral pH-modified release budesonide versus 6-methylprednisolone in active Crohn's disease"" does not provide indirect support for the claim that ""Hydrocortisone causes Sepsis"". The study referenced in the title is investigating two different treatments for Crohn's disease, neither of which is Hydrocortisone. The connection between these two pieces of information is tenuous at best, as there is no mention of Hydrocortisone in the study title or its implications for sepsis. Sepsis is a serious condition that can be caused by various factors, including infections; however, it is not caused by Hydrocortisone itself. Hydrocortisone is a medication used primarily for its anti-inflammatory effects in various conditions such as allergies, skin disorders, and autoimmune diseases." +27073884,Hydrocortisone causes atopic eczema,391,Pharmacokinetics of high dose methylprednisolone and use in hematological malignancies.,False,"'Does the phrase ""Hydrocortisone causes atopic eczema"" receive at least indirect support from the statement: ""Pharmacokinetics of high dose methylprednisolone and use in hematological malignancies.""?","No, the statement ""Pharmacokinetics of high dose methylprednisolone and use in hematological malignancies"" does not provide any direct or indirect support for the claim that ""Hydrocortisone causes atopic eczema."" - Although hydrocortisone is a hormone that can influence various physiological processes in humans (including mood regulation), there is no direct link established between hydrocortisone and BPD in this statement. To support such a claim, one would need evidence from studies involving human subjects diagnosed with BPD, assessing hydrocortisone levels, response to hydrocortisone treatment, or other relevant factors. + The statement is about pharmacokinetics (the process of how a drug is absorbed, distributed, metabolized, and excreted) of high dose methylprednisolone (a type of corticosteroid) in hematological malignancies (blood cancers). It does not mention hydrocortisone at all, nor does it discuss any relationship between corticosteroids and atopic eczema. - Therefore, it is crucial to remain cautious when interpre" -12576998,Hydrocortisone related to Hypoxemia,361,The results demonstrated that the intrarectal dose of indomethacin and hydrocortisone inhibited the development of tumors from microscopic carcinoma lesions in the large bowel and growing further.,False,Is the triple 'Hydrocortisone related to Hypoxemia' supported by the sentence: 'The results demonstrated that the intrarectal dose of indomethacin and hydrocortisone inhibited the development of tumors from microscopic carcinoma lesions in the large bowel and growing further.'?,"No, the statement does not provide indirect support for the phrase ""Hydrocortisone related to Hypoxemia"". The statement discusses the effects of intrarectal doses of indomethacin and hydrocortisone on tumor development in the large bowel, but it does not mention or imply anything about hypoxemia, which is a condition characterized by low levels of oxygen in the blood. Hypoxemia is not even remotely related to tumor development or inhibition in this context. Therefore, without further information linking hydrocortisone to hypoxemia specifically, there is no basis for such a claim." -11888652,Hydrocortisone related to congenital adrenal hyperplasia,362,"Growth of ovarian, lung, breast, and kidney carcinomas was increased by 136%, 126%, 78% and 69%, respectively, whereas melanomas, sarcomas, and colon tumors were inhibited by hydrocortisone.",False,"Is the triple 'Hydrocortisone related to congenital adrenal hyperplasia' supported by the sentence: 'Growth of ovarian, lung, breast, and kidney carcinomas was increased by 136%, 126%, 78% and 69%, respectively, whereas melanomas, sarcomas, and colon tumors were inhibited by hydrocortisone.'?","No, the statement does not provide indirect support for the phrase ""Hydrocortisone related to congenital adrenal hyperplasia."" The statement discusses the effects of hydrocortisone on various types of carcinomas and tumors but does not mention congenital adrenal hyperplasia (CAH). CAH is a genetic disorder resulting from mutations in genes encoding enzymes necessary for cortisol biosynthesis in the adrenal glands; it is not caused by exposure to hydrocortisone. Therefore, while hydrocortisone may have an impact on carcinomas and tumors as stated in the given claim, it does not imply any connection between hydrocortisone and CAH." -11866289,Hydrocortisone related to nicotine dependence,363,Insufficient cortisol limits the ability of the sick newborn to handle stress and inhibit pulmonary inflammation.,False,Is the triple 'Hydrocortisone related to nicotine dependence' supported by the sentence: 'Insufficient cortisol limits the ability of the sick newborn to handle stress and inhibit pulmonary inflammation.'?,"No, the statement does not provide indirect support for the phrase ""Hydrocortisone related to nicotine dependence"". + Atopic eczema is a chronic inflammatory skin condition that can be exacerbated by various factors including stress, changes in temperature or humidity, and certain types of medications including corticosteroids like hydrocortisone. However, saying that hydrocortisone causes atopic eczema is not accurate because while it may exacerbate existing symptoms in some individuals, it does not cause the condition itself. - + Therefore, without any reference made to" +25383174,Hydrocortisone causes fibromyalgia,392,"Methylprednisolone in advanced chronic lymphocytic leukaemia: rationale for, and effectiveness of treatment suggested by DiSC assay.",False,"'Does the phrase ""Hydrocortisone causes fibromyalgia"" receive at least indirect support from the statement: ""Methylprednisolone in advanced chronic lymphocytic leukaemia: rationale for, and effectiveness of treatment suggested by DiSC assay.""?","No, the statement does not provide indirect support for the phrase ""Hydrocortisone causes fibromyalgia."" The statement discusses Methylprednisolone, which is a different type of corticosteroid than Hydrocortisone, being used in advanced chronic lymphocytic leukaemia patients. There is no mention of fibromyalgia in the statement, nor any connection made between corticosteroids (including Hydrocortisone) and fibromyalgia development." +25205462,Hydrocortisone causes hypotensive disorder,393,The effects of intravenous pulse methylprednisolone on immunological and inflammatory processes in ankylosing spondylitis.,False,"'Does the phrase ""Hydrocortisone causes hypotensive disorder"" receive at least indirect support from the statement: ""The effects of intravenous pulse methylprednisolone on immunological and inflammatory processes in ankylosing spondylitis.""?","No, the statement does not provide indirect support for the phrase ""Hydrocortisone causes hypotensive disorder."" The statement discusses the effects of intravenous pulse methylprednisolone on immunological and inflammatory processes in ankylosing spondylitis, which is unrelated to hydrocortisone or hypotensive disorder. Hydrocortisone is a different type of corticosteroid medication than methylprednisolone; therefore, any potential effects on blood pressure would need separate evaluation." +20591759,Hydrocortisone causes Hypoxemia,394,The effect of methylprednisolone (MP) on the cell kinetic response to cyclophosphamide (CP) and Adriamycin (ADR) in C3H/HeJ spontaneous mammary tumors and hematopoietic tissue was investigated.,False,"'Does the phrase ""Hydrocortisone causes Hypoxemia"" receive at least indirect support from the statement: ""The effect of methylprednisolone (MP) on the cell kinetic response to cyclophosphamide (CP) and Adriamycin (ADR) in C3H/HeJ spontaneous mammary tumors and hematopoietic tissue was investigated.""?","No, the statement does not provide any indirect support for the claim that ""Hydrocortisone causes Hypoxemia."" The statement discusses an investigation into the effect of methylprednisolone (MP) on cell kinetic response to cyclophosphamide (CP) and Adriamycin (ADR) in C3H/HeJ spontaneous mammary tumors and hematopoietic tissue. Hydrocortisone is not mentioned in this statement, nor is hypoxemia, which is a condition characterized by low levels of oxygen in the blood. Therefore, it is not possible to draw any conclusions about hydrocortisone causing hypoxemia based on this statement alone." +18446972,Hydrocortisone causes congenital adrenal hyperplasia,395,High-dose intravenous methyl-prednisolone in chronic polymyositis/dermatomyositis.,False,"'Does the phrase ""Hydrocortisone causes congenital adrenal hyperplasia"" receive at least indirect support from the statement: ""High-dose intravenous methyl-prednisolone in chronic polymyositis/dermatomyositis.""?","No, the statement ""High-dose intravenous methyl-prednisolone in chronic polymyositis/dermatomyositis"" does not provide indirect support for the claim that ""Hydrocortisone causes congenital adrenal hyperplasia."" - The statement discusses the role of cortisol, a hormone that the body produces in response to stress, in newborns. It suggests that insufficient cortisol levels can impact a newborn's ability to manage stress and inhibit pulmonary inflammation. + The two statements discuss different corticosteroids (methyl-prednisolone vs hydrocortisone) and different medical conditions (polymyositis/dermatomyositis vs congenital adrenal hyperplasia). Methyl-prednisolone is not hydrocortisone, and polymyositis/dermatomyositis is not congenital adrenal hyperplasia. - + Congenital adrenal hyperplasia (CAH) is primarily caused by genetic defects in enzymes involved in cortisol synthesis in the adrenal glands, not by exposure to exogenous corticosteroids such as hydrocortisone (or methyl-prednisolone) during pregnancy (Speiser et al., 2018). - Hydrocortisone is a synthetic form of cortisol often used in medical treatments. While it is true that hydrocortisone can help manage stress and inflammation, there is no mention of nicotine or nicotine dependence in the statement. Nicotine dependence is a complex condition involving both psychological and physiological factors, which is not addressed in the statement. Therefore, it does not provide indirect support for the phrase ""Hydrocortisone related to nicotine dependence""." -11530989,Hydrocortisone related to pneumonia,364,"BACKGROUND: Hepatic 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) activity, which converts cortisone (inactive) to cortisol, is downregulated in obesity.",False,"Is the triple 'Hydrocortisone related to pneumonia' supported by the sentence: 'BACKGROUND: Hepatic 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) activity, which converts cortisone (inactive) to cortisol, is downregulated in obesity.'?","No, the statement does not provide direct or indirect support for the phrase ""Hydrocortisone related to pneumonia."" The background statement discusses hepatic 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) activity, its role in converting cortisone (inactive) to cortisol, and its downregulation in obesity. Hydrocortisone is a synthetic glucocorticoid that is commonly prescribed to treat various conditions such as inflammation, allergies, and adrenal insufficiency but is not directly mentioned in the background statement nor linked to pneumonia in any way. + In conclusion, there is no indirect support for the claim that hydro" +18240145,Hydrocortisone causes injury,396,Comparing Intratympanic Gentamicin with Methylprednisolone in Meniere's Disease with Non-Serviceable Hearing.,False,"'Does the phrase ""Hydrocortisone causes injury"" receive at least indirect support from the statement: ""Comparing Intratympanic Gentamicin with Methylprednisolone in Meniere's Disease with Non-Serviceable Hearing.""?","No, the statement ""Comparing Intratympanic Gentamicin with Methylprednisolone in Meniere's Disease with Non-Serviceable Hearing"" does not provide indirect support for the phrase ""Hydrocortisone causes injury."" The statement is about a comparative study between Intratympanic Gentamicin and Methylprednisolone in Meniere's Disease with Non-Serviceable Hearing. Hydrocortisone is not mentioned in this statement, hence it does not offer any support for the claim that Hydrocortisone causes injury." +17359303,Hydrocortisone causes influenza,397,"High-dose methylprednisolone, vincristine, MTX, and ara-C (SOMA) as initial bulk reducing therapy in non-Hodgkin's lymphoma of unfavorable histology: preliminary results of an ongoing phase II study.",False,"'Does the phrase ""Hydrocortisone causes influenza"" receive at least indirect support from the statement: ""High-dose methylprednisolone, vincristine, MTX, and ara-C (SOMA) as initial bulk reducing therapy in non-Hodgkin's lymphoma of unfavorable histology: preliminary results of an ongoing phase II study.""?","No, the statement does not provide any indirect support for the claim that ""Hydrocortisone causes influenza."" The statement is about high-dose methylprednisolone, vincristine, MTX, and ara-C as initial bulk reducing therapy in non-Hodgkin's lymphoma of unfavorable histology in an ongoing phase II study. Hydrocortisone is not mentioned in this statement, nor is there any connection made between these treatments and influenza." +13585273,"Hydrocortisone causes dermatitis, atopic",398,A Prospective Study Comparing the Efficacy of Local Injection of Platelet-Rich Plasma (PRP) vs Methylprednisolone in Plantar Fasciitis.,False,"'Does the phrase ""Hydrocortisone causes dermatitis, atopic"" receive at least indirect support from the statement: ""A Prospective Study Comparing the Efficacy of Local Injection of Platelet-Rich Plasma (PRP) vs Methylprednisolone in Plantar Fasciitis.""?","No, the statement ""A Prospective Study Comparing the Efficacy of Local Injection of Platelet-Rich Plasma (PRP) vs Methylprednisolone in Plantar Fasciitis"" does not provide indirect support for the phrase ""Hydrocortisone causes dermatitis, atopic"". - To establish a connection between hydrocortisone and pneumonia, one would need evidence showing how altered 11beta-HSD1 activity in obesity affects hydrocortisone levels and how these changes could increase susceptibility to pneumonia. The background statement provided does not offer such evidence or implications; therefore, it does not support the initial phrase in question. + The study in question compares the efficacy of two treatments for plantar fasciitis, one of which involves the use of methylprednisolone. Hydrocortisone is a different type of corticosteroid than methylprednisolone, and while both can have side effects including dermatitis, the study does not make any direct or indirect connections between hydrocortisone and dermatitis. - To further clarify, hydrocortisone (cortisol) downregulation due to" -11442939,Hydrocortisone related to prostate cancer,365,"High-dose hydrocortisone treatment given in the first few hours after a traumatic experience was associated with significant favorable changes in the trajectory of exposure to trauma, as expressed by the reduced risk of the development of PTSD post-trauma.",False,"Is the triple 'Hydrocortisone related to prostate cancer' supported by the sentence: 'High-dose hydrocortisone treatment given in the first few hours after a traumatic experience was associated with significant favorable changes in the trajectory of exposure to trauma, as expressed by the reduced risk of the development of PTSD post-trauma.'?","No, the statement does not provide indirect support for the phrase ""Hydrocortisone related to prostate cancer."" The statement discusses the association between high-dose hydrocortisone treatment and reduced risk of post-traumatic stress disorder (PTSD) development after a traumatic experience. This finding is related to psychiatric disorders rather than prostate cancer. Therefore, it does not offer any relevant information or implications regarding hydrocortisone's relationship with prostate cancer." -11089023,Hydrocortisone related to pancreatitis,366,"Under normal conditions, stress induces increased cortisol secretion that counteracts inflammatory reactions.",False,"Is the triple 'Hydrocortisone related to pancreatitis' supported by the sentence: 'Under normal conditions, stress induces increased cortisol secretion that counteracts inflammatory reactions.'?","No, the statement does not provide indirect support for the phrase ""Hydrocortisone related to pancreatitis."" The statement suggests that cortisol, under normal conditions, has an anti-inflammatory effect during stress responses. Hydrocortisone is a synthetic glucocorticoid often used as a replacement therapy for adrenal insufficiency and has potent anti-inflammatory effects similar to those of cortisol. However, this information does not necessarily imply a connection between hydrocortisone use and pancreatitis risk without additional evidence specifically linking these two factors together." -10649902,Hydrocortisone related to myocardial infarction,367,Hydrocortisone (HC) reduced the macrophage content of four murine tumors to less than half of control values.,False,Is the triple 'Hydrocortisone related to myocardial infarction' supported by the sentence: 'Hydrocortisone (HC) reduced the macrophage content of four murine tumors to less than half of control values.'?,"No, the statement ""Hydrocortisone (HC) reduced the macrophage content of four murine tumors to less than half of control values"" does not provide indirect support for the phrase ""Hydrocortisone related to myocardial infarction."" + Furthermore, even if the study had mentioned hydrocortisone, it would still not provide sufficient evidence for the claim that ""hydrocortisone causes dermatitis"". A single prospective study on a different medical condition (plantar fasciitis) would not be enough to establish causality for a different condition (dermatitis). Causality would require a much more rigorous set of studies" +12645476,Hydrocortisone causes obesity disorder,399,A controlled trial of 6-methylprednisolone in acute alcoholic hepatitis.,False,"'Does the phrase ""Hydrocortisone causes obesity disorder"" receive at least indirect support from the statement: ""A controlled trial of 6-methylprednisolone in acute alcoholic hepatitis.""?","No, the statement does not provide any direct or indirect support for the claim that hydrocortisone causes obesity disorder. The reason is that 6-methylprednisolone is not hydrocortisone, although they both belong to the class of corticosteroids. The study does not mention hydrocortisone at all, so it cannot be inferred that hydrocortisone has any connection to obesity disorder based on this statement alone. - The reason for this is that while both statements involve hydrocortisone, they discuss different biological processes: tumor macrophage content in mice and myocardial infarction in humans, respectively. A correlation between hydrocortisone usage and reduced macrophage content in tumors does not necessarily imply any relationship between hydrocortisone and myocardial infarction risk in humans. + To further clarify, corticosteroids such as hydrocortisone and 6-methylprednisolone have various therapeutic uses, including treating inflammatory diseases and autoimmune disorders; however, they have also been associated with side effects such as weight gain (central obesity) due to increased appetite and fluid retention. This does not mean that corticosteroids cause ""obesity disorder"" but rather that they can contribute to weight gain as part of their side effect profile. - Furthermore, even if there were a correlation between hydrocortisone usage and myocardial infarction risk in humans, it would not necessarily imply causation; other confounding variables could be influencing both hydrocortisone usage and myocardial infarction risk. + It is essential always to evaluate each study based on its specific design, population, intervention, comparison group (control), outcomes measured, and statistical analyses (the so-called ""PICOS" +10068843,Hydrocortisone causes Inflammation,400,[Short-term therapy with methylprednisolone in exacerbated obstructive respiratory tract diseases].,False,"'Does the phrase ""Hydrocortisone causes Inflammation"" receive at least indirect support from the statement: ""[Short-term therapy with methylprednisolone in exacerbated obstructive respiratory tract diseases].""?","No, the statement does not provide any indirect support for the phrase ""Hydrocortisone causes Inflammation."" The statement discusses short-term therapy with methylprednisolone in exacerbated obstructive respiratory tract diseases. Methylprednisolone is a synthetic glucocorticoid, similar to hydrocortisone in that they both belong to the class of corticosteroids, but they have different pharmacological properties and uses. - Therefore, while both statements involve hydrocortisone, they discuss different biological processes in different organisms, making it impossible to draw any meaningful connections between them without additional information linking hydrocort" -10522181,Hydrocortisone related to osteoarthritis,368,"Further, because infant formula contains only trace amounts of glucocorticoids, these findings suggest that cortisol in milk is a novel biological pathway through which breastfeeding may protect against later obesity.",False,"Is the triple 'Hydrocortisone related to osteoarthritis' supported by the sentence: 'Further, because infant formula contains only trace amounts of glucocorticoids, these findings suggest that cortisol in milk is a novel biological pathway through which breastfeeding may protect against later obesity.'?","No, the statement does not provide direct or indirect support for the phrase ""Hydrocortisone related to osteoarthritis."" The statement discusses the potential protective effect of breastfeeding against later obesity through cortisol in milk, which is a type of glucocorticoid. However, it does not mention hydrocortisone specifically nor make any connection to osteoarthritis. Hydrocortisone is one type of glucocorticoid but is not explicitly mentioned in the statement, so no inference can be made regarding its relationship to osteoarthritis based on this information alone." -10521296,Hydrocortisone related to eye disorder,369,"Conclusions and Relevance: Among adults with severe sepsis not in septic shock, use of hydrocortisone compared with placebo did not reduce the risk of septic shock within 14 days.",False,"Is the triple 'Hydrocortisone related to eye disorder' supported by the sentence: 'Conclusions and Relevance: Among adults with severe sepsis not in septic shock, use of hydrocortisone compared with placebo did not reduce the risk of septic shock within 14 days.'?","No, the statement does not provide indirect support for the phrase ""Hydrocortisone related to eye disorder"". The conclusion drawn in the statement is about hydrocortisone use in adults with severe sepsis not in septic shock and its effect on reducing septic shock risk within 14 days. There is no mention or implication of any eye disorder in relation to hydrocortisone in this statement." -10518203,Hydrocortisone related to otitis externa,370,These findings suggest that HC may protect against hyperoxic injury in the developing pulmonary vasculature.,False,Is the triple 'Hydrocortisone related to otitis externa' supported by the sentence: 'These findings suggest that HC may protect against hyperoxic injury in the developing pulmonary vasculature.'?,"No, the statement does not provide indirect support for the phrase ""Hydrocortisone related to otitis externa."" The finding suggests that hydrocortisone (HC) may have protective effects against hyperoxic injury in the developing pulmonary vasculature. Otitis externa refers to inflammation or infection of the outer ear canal, which is unrelated to pulmonary vasculature in which hydrocortisone is found to have potential benefits in this study." -10484611,Hydrocortisone related to ulcerative colitis,371,OBJECTIVE: Cortisol clearance is reduced in sepsis and may contribute to the development of impaired adrenocortical function that is thought to contribute to the pathophysiology of critical illness-related corticosteroid insufficiency.,False,Is the triple 'Hydrocortisone related to ulcerative colitis' supported by the sentence: 'OBJECTIVE: Cortisol clearance is reduced in sepsis and may contribute to the development of impaired adrenocortical function that is thought to contribute to the pathophysiology of critical illness-related corticosteroid insufficiency.'?,"No, I would argue that the statement does not provide direct or indirect support for the phrase ""Hydrocortisone related to ulcerative colitis."" The statement discusses cortisol clearance in sepsis and its potential contribution to impaired adrenocortical function in critical illness-related corticosteroid insufficiency. Hydrocortisone is a synthetic form of cortisol (a hormone produced by the adrenal gland), but the statement does not make any mention of ulcerative colitis or hydrocortisone treatment for this condition. + Hydrocortisone is primarily used for its anti-inflammatory effects, whereas methylprednisolone is often used for its immunosuppressive properties in addition to its anti-inflammatory effects. Therefore, any conclusions about hydrocortisone cannot be inferred from the statement provided about methylprednisolone. - Ulcerative colitis is an inflammatory bowel disease (IBD) characterized by chronic inflammation in the colon lining. Corticosteroids like hydrocortisone can be used in managing IBD symptoms; however, they do not specifically target ulcerative colitis but rather reduce inflammation more generally in the gut. The statement in question focuses on sepsis-induced corticosteroid insufficiency rather than IBD or ulcerative colitis treatment. + To further clarify, hydrocortisone itself does not cause inflammation; instead, it is commonly prescribed as an anti-inflammatory medication to manage various conditions associated with inflammation in the body." +9850315,Hydrocortisone causes dissociative amnesia,401,Methylprednisolone and 60 Days in Hospital Survival in Coronavirus Disease 2019 Pneumonia.,False,"'Does the phrase ""Hydrocortisone causes dissociative amnesia"" receive at least indirect support from the statement: ""Methylprednisolone and 60 Days in Hospital Survival in Coronavirus Disease 2019 Pneumonia.""?","No, the statement ""Methylprednisolone and 60 Days in Hospital Survival in Coronavirus Disease 2019 Pneumonia"" does not provide indirect support for the claim that ""Hydrocortisone causes dissociative amnesia."" - In conclusion, while hydrocortisone is indeed related to cortisol metabolism, which is" -9718673,Hydrocortisone related to atopic eczema,372,Hydrocortisone therapy was started to prevent adrenal insufficiency before laboratory findings for ACTH (adrenocorticotropic hormone) and cortisol levels.,False,Is the triple 'Hydrocortisone related to atopic eczema' supported by the sentence: 'Hydrocortisone therapy was started to prevent adrenal insufficiency before laboratory findings for ACTH (adrenocorticotropic hormone) and cortisol levels.'?,"No, the statement does not provide direct or indirect support for the phrase ""Hydrocortisone related to atopic eczema"". The statement mentions that hydrocortisone therapy was initiated to prevent adrenal insufficiency due to low ACTH (adrenocorticotropic hormone) and cortisol levels. This is unrelated to atopic eczema treatment as hydrocortisone is also used for various conditions where anti-inflammatory properties are required. The connection between hydrocortisone therapy in this context and atopic eczema is not apparent in the given statement." -9492934,Hydrocortisone related to opiate dependence,373,CONCLUSION: We conclude that intravenous stress doses of hydrocortisone lead to a reduction of systemic inflammation and to a potential improvement in the early outcome of patients undergoing off-pump CABG.,False,Is the triple 'Hydrocortisone related to opiate dependence' supported by the sentence: 'CONCLUSION: We conclude that intravenous stress doses of hydrocortisone lead to a reduction of systemic inflammation and to a potential improvement in the early outcome of patients undergoing off-pump CABG.'?,"No, the statement does not provide any indirect support for the connection between hydrocortisone and opiate dependence. The conclusion in question discusses the effects of intravenous stress doses of hydrocortisone on systemic inflammation in patients undergoing off-pump coronary artery bypass graft (CABG) surgery and its potential impact on early patient outcomes. It does not mention opiate dependence or related topics at all. Therefore, it is not reasonable to infer any relationship between hydrocortisone use and opiate dependence based on the provided conclusion." -9238280,Hydrocortisone related to Sepsis,374,"CONCLUSION: In intubated trauma patients, the use of an intravenous stress-dose of hydrocortisone, compared with placebo, resulted in a decreased risk of hospital-acquired pneumonia.",False,"Is the triple 'Hydrocortisone related to Sepsis' supported by the sentence: 'CONCLUSION: In intubated trauma patients, the use of an intravenous stress-dose of hydrocortisone, compared with placebo, resulted in a decreased risk of hospital-acquired pneumonia.'?","No, the statement ""CONCLUSION: In intubated trauma patients, the use of an intravenous stress-dose of hydrocortisone, compared with placebo, resulted in a decreased risk of hospital-acquired pneumonia"" does not provide indirect support for the phrase ""Hydrocortisone related to Sepsis"". This conclusion is about hydrocortisone use reducing hospital-acquired pneumonia risk in intubated trauma patients compared to placebo. Sepsis is not mentioned in this conclusion; therefore, it does not imply any relationship between hydrocortisone and sepsis." -9235597,Hydrocortisone related to type 1 diabetes mellitus,375,"Early hydrocortisone (HC) treatment may decrease the incidence of bronchopulmonary dysplasia; however, the long-term effects are still under evaluation.",False,"Is the triple 'Hydrocortisone related to type 1 diabetes mellitus' supported by the sentence: 'Early hydrocortisone (HC) treatment may decrease the incidence of bronchopulmonary dysplasia; however, the long-term effects are still under evaluation.'?","No, the statement does not provide direct or indirect support for the phrase ""Hydrocortisone related to type 1 diabetes mellitus."" The statement discusses the use of hydrocortisone (HC) in relation to bronchopulmonary dysplasia, not type 1 diabetes mellitus. Therefore, it does not contribute any evidence or reasoning towards understanding a potential relationship between hydrocortisone and type 1 diabetes mellitus." -8977987,Hydrocortisone related to injury,376,CONCLUSION: Intravenous hydrocortisone reduced the incidence of AF after cardiac surgery.,False,Is the triple 'Hydrocortisone related to injury' supported by the sentence: 'CONCLUSION: Intravenous hydrocortisone reduced the incidence of AF after cardiac surgery.'?,"No, the statement does not provide indirect support for the phrase ""Hydrocortisone related to injury."" The conclusion in question comes from a study that examines the effects of intravenous hydrocortisone on atrial fibrillation (AF) after cardiac surgery. While it demonstrates an association between hydrocortisone use and reduced incidence of AF in this specific context, it does not provide evidence linking hydrocortisone directly to injury. + The statement in question is a title of a study that investigates the effect of Methylprednisolone on survival rates in COVID-19 patients. It does not mention Hydrocortisone at all, let alone its potential effects on cognition or memory. Dissociative amnesia is a specific condition characterized by gaps in memory that cannot be explained by ordinary forgetfulness. It is not typically associated with corticosteroid use such as Hydrocortisone or Methylprednisolone. - To further elaborate on this point: + Therefore, without further information linking Hydrocortisone use to dissociative amnesia, it is inappropriate to infer support for such a claim from this study title." +9318796,Hydrocortisone causes adrenocortical insufficiency,402,Intra-Carpal Injection of Ozone versus Methylprednisolone in Carpal Tunnel Syndrome of Systemic Sclerosis Patients: A Randomized Single-Blind Clinical Trial.,False,"'Does the phrase ""Hydrocortisone causes adrenocortical insufficiency"" receive at least indirect support from the statement: ""Intra-Carpal Injection of Ozone versus Methylprednisolone in Carpal Tunnel Syndrome of Systemic Sclerosis Patients: A Randomized Single-Blind Clinical Trial.""?","No, the statement ""Intra-Carpal Injection of Ozone versus Methylprednisolone in Carpal Tunnel Syndrome of Systemic Sclerosis Patients: A Randomized Single-Blind Clinical Trial"" does not provide indirect support for the phrase ""Hydrocortisone causes adrenocortical insufficiency."" - 1) The study investigates hydrocortisone use in relation to AF after cardiac surgery - not injury; - 2) Although hydrocortisone is used as an anti-inflammatory agent, which implies its potential involvement in injury response, no direct causal link between hydrocortisone use and injury reduction is established in the provided statement; - 3) The study does not discuss any other potential adverse effects related to injury that may be associated with hydrocortisone use; - 4) The statement does not provide any context about other studies that might support the connection between hydrocortisone use and injury reduction; - 5" -8778414,Hydrocortisone related to Inflammation,377,"Assuming a single dose of hydrocortisone improves sensitivity of peripheral tissues to insulin, it may be an interesting candidate for use in reducing insulin resistance in peripheral tissues of horses with several disease states.",False,"Is the triple 'Hydrocortisone related to Inflammation' supported by the sentence: 'Assuming a single dose of hydrocortisone improves sensitivity of peripheral tissues to insulin, it may be an interesting candidate for use in reducing insulin resistance in peripheral tissues of horses with several disease states.'?","No, the statement does not provide direct or indirect support for the phrase ""Hydrocortisone related to Inflammation"". The statement discusses hydrocortisone's potential impact on insulin resistance in horses, but it does not mention or imply any connection to inflammation. Hydrocortisone is indeed known for its anti-inflammatory effects in various disease states in humans and animals, but that aspect is not addressed in the given statement. Therefore, it cannot be used as evidence to support the claim about hydrocortisone being related to inflammation." -8763179,Hydrocortisone related to toxic shock syndrome,378,Plasma cortisol and glucagon concentrations were not increased markedly except in a case complicated other systemic bacterial infection.,False,Is the triple 'Hydrocortisone related to toxic shock syndrome' supported by the sentence: 'Plasma cortisol and glucagon concentrations were not increased markedly except in a case complicated other systemic bacterial infection.'?,"No, the statement does not provide indirect support for the phrase ""Hydrocortisone related to toxic shock syndrome"". The statement discusses plasma cortisol concentrations in relation to bacterial infection but does not mention hydrocortisone or toxic shock syndrome. Hydrocortisone is a synthetic form of cortisol, but no connection is drawn between it and toxic shock syndrome in this statement." -8625521,Hydrocortisone related to dissociative amnesia,379,"In view of the stimulatory effects of insulin and cortisol on adipogenesis, long-term stimulation of 11betaHSD reductase activity by insulin could aggravate visceral obesity.",False,"Is the triple 'Hydrocortisone related to dissociative amnesia' supported by the sentence: 'In view of the stimulatory effects of insulin and cortisol on adipogenesis, long-term stimulation of 11betaHSD reductase activity by insulin could aggravate visceral obesity.'?","No, the statement ""Hydrocortisone related to dissociative amnesia"" does not receive indirect support from the provided statement about insulin and cortisol stimulating adipogenesis (the process by which preadipocytes become adipocytes, or fat cells) and 11betaHSD reductase activity potentially aggravating visceral obesity (excessive fat accumulation in the abdominal region). + The study in question is comparing the efficacy of ozone and methylprednisolone in treating carpal tunnel syndrome in patients with systemic sclerosis. Methylprednisolone is a synthetic glucocorticoid, similar to hydrocortisone, which is often used in medical treatments to reduce inflammation. - The given statement is focused on insulin and cortisol's effects on adipogenesis and obesity development, not on their relationship with dissociative amnesia, which is characterized by memory loss due to psychological trauma rather than hormonal imbalances. + While both hydrocortisone and methylprednisolone can cause adrenocortical insufficiency as a side effect due to their glucocorticoid nature, this study does not provide any evidence or discussion about this potential side effect. Therefore, it does not indirectly support the claim that hydrocortisone causes adrenocortical insufficiency. - Hydrocortisone is a synthetic glucocorticoid hormone that is often used as an anti-inflammatory drug in medical treatments; it is not related to insulin in terms of structure or function. While both hormones can impact fat metabolism, there is no clear connection between hydrocortisone use and dissociative amnesia based on the provided statement alone. + It is important to note that adrenocortical" +9145908,Hydrocortisone causes otitis externa,403,Methylprednisolone Pulses in West Syndrome: A New Weapon in the Armory-Is it Needed?,False,"'Does the phrase ""Hydrocortisone causes otitis externa"" receive at least indirect support from the statement: ""Methylprednisolone Pulses in West Syndrome: A New Weapon in the Armory-Is it Needed?""?","No, the statement ""Methylprednisolone Pulses in West Syndrome: A New Weapon in the Armory-Is it Needed?"" does not provide indirect support for the phrase ""Hydrocortisone causes otitis externa."" The study focuses on Methylprednisolone Pulses as a treatment for West Syndrome, which is a type of epilepsy. The drug Hydrocortisone is not mentioned in the study at all, let alone its potential side effect of causing otitis externa (outer ear infection). Therefore, there is no logical connection that can be made between these two statements based on the provided evidence." +8699464,Hydrocortisone causes adrenal cortex neoplasm,404,Patient underwent treatment with milrinone and methylprednisolone that showed reduction in myocardial inflammation and significantly improved myocardial contractility.,False,"'Does the phrase ""Hydrocortisone causes adrenal cortex neoplasm"" receive at least indirect support from the statement: ""Patient underwent treatment with milrinone and methylprednisolone that showed reduction in myocardial inflammation and significantly improved myocardial contractility.""?","No, the statement does not provide indirect support for the phrase ""Hydrocortisone causes adrenal cortex neoplasm."" - Therefore, further information would be required in order" -8615164,Hydrocortisone related to asthma,380,"For this purpose, this review article contends that plasma cortisol is linked to a greater risk of AF.",False,"Is the triple 'Hydrocortisone related to asthma' supported by the sentence: 'For this purpose, this review article contends that plasma cortisol is linked to a greater risk of AF.'?","No, the statement does not provide indirect support for the phrase ""Hydrocortisone related to asthma."" The review article discusses plasma cortisol being linked to a greater risk of atrial fibrillation (AF), not asthma. Hydrocortisone is a synthetic glucocorticoid that mimics cortisol in the body; however, it is not explicitly mentioned in relation to asthma in the statement provided. + The statement discusses a patient who received treatment with milrinone and methylprednisolone, which resulted in reduced myocardial inflammation and improved myocardial contractility. Methylprednisolone is a synthetic glucocorticoid similar to hydrocortisone in its anti-inflammatory effects; however, it does not imply that hydrocortisone causes adrenal cortex neoplasm (tumors). Adrenal cortex neoplasm is associated with various factors including genetic predisposition, exposure to certain chemicals, and other medical conditions like Li-Fraumeni syndrome. It is crucial to differentiate between correlation and causation in interpreting such information." +8657746,Hydrocortisone causes neoplasm,405,"Neurologically, the therapeutic dosages of anticoagulants are linked to the high incidence of thrombotic complexities, while methylprednisolone is associated with myopathy.",False,"'Does the phrase ""Hydrocortisone causes neoplasm"" receive at least indirect support from the statement: ""Neurologically, the therapeutic dosages of anticoagulants are linked to the high incidence of thrombotic complexities, while methylprednisolone is associated with myopathy.""?","No, the statement does not provide indirect support for the phrase ""Hydrocortisone causes neoplasm."" The statement discusses neurological side effects of anticoagulants and muscle-related side effects of methylprednisolone, but it does not mention any connection between hydrocortisone and neoplasms (abnormal growths that can be benign or malignant). Therefore, based on this statement alone, there is no basis for inferring that hydrocortisone is associated with neoplasm development." +7929803,Hydrocortisone causes Insulin resistance,406,"Conclusion: Based on the current data, the efficacy and safety of local injection of triamcinolone and methylprednisolone at doses of 20 and 40 mg were associated with a significant improvement in pain, functional status, and strength.",False,"'Does the phrase ""Hydrocortisone causes Insulin resistance"" receive at least indirect support from the statement: ""Conclusion: Based on the current data, the efficacy and safety of local injection of triamcinolone and methylprednisolone at doses of 20 and 40 mg were associated with a significant improvement in pain, functional status, and strength.""?","No, the statement does not provide indirect support for the phrase ""Hydrocortisone causes Insulin resistance"". The conclusion presented in the statement is about the efficacy and safety of local injections of triamcinolone and methylprednisolone at specific doses in improving pain, functional status, and strength. Hydrocortisone is not mentioned in the statement; therefore, it is not possible to draw any conclusions about its relationship with insulin resistance based on this information alone. - To establish an indirect link between hydrocortisone and asthma in this context, there would need to be evidence connecting cortisol levels (or glucocorticoids like hydrocortisone) to asthma development or exacerbation. Since no such connection is made in the statement provided, we cannot infer support for ""Hydrocortisone related to asthma."" + Insulin resistance is a condition in which cells become less responsive to insulin, leading to high blood sugar levels. Glucocorticoids like hydrocortisone can contribute to insulin resistance by affecting glucose metabolism in various tissues. However, in order to establish a connection between hydrocortisone use and insulin resistance, direct evidence specific to hydrocortisone would be required. - In summary, while hydrocortisone is related to cortisol in its glucocorticoid action, there is no explicit connection made between hydrocortisone and asthma in the statement provided. Therefore, it does not offer indirect support for that specific phrase." -8570630,Hydrocortisone related to fibromyalgia,381,"After multivariate analysis, duration of HC stress dose administration was associated with increased risk of mortality (OR 1.11, 95% CI 1.02-1.2, p = 0.021), and total duration of HC treatment was associated with increased risk of sepsis (OR 1.04, 95% CI 1.005-1.075, p = 0.026).",False,"Is the triple 'Hydrocortisone related to fibromyalgia' supported by the sentence: 'After multivariate analysis, duration of HC stress dose administration was associated with increased risk of mortality (OR 1.11, 95% CI 1.02-1.2, p = 0.021), and total duration of HC treatment was associated with increased risk of sepsis (OR 1.04, 95% CI 1.005-1.075, p = 0.026).'?","No, the statement does not provide indirect support for the phrase ""Hydrocortisone related to fibromyalgia."" The provided statement discusses the association between hydrocortisone (HC) stress dose administration duration and mortality risk as well as total duration of HC treatment and sepsis risk in a given population. However, it does not mention fibromyalgia nor provide any information that would imply a relationship between hydrocortisone usage and fibromyalgia." -8017438,Hydrocortisone related to Insulin resistance,382,"Plasma leptin and ghrelin levels in endotoxin-treated dogs were correlated with serum nitric oxide (r = .955 and r = .890; p < .001), procalcitonin (r = .825 and r = .716; p < .001), cortisol (r = .823 and r = .786; p < .001), and hepatorenal injury markers (r = .580 to .745 and r = .393 to .574; p < .05 to .01).",False,"Is the triple 'Hydrocortisone related to Insulin resistance' supported by the sentence: 'Plasma leptin and ghrelin levels in endotoxin-treated dogs were correlated with serum nitric oxide (r = .955 and r = .890; p < .001), procalcitonin (r = .825 and r = .716; p < .001), cortisol (r = .823 and r = .786; p < .001), and hepatorenal injury markers (r = .580 to .745 and r = .393 to .574; p < .05 to .01).'?","No, the statement does not provide direct support for the phrase ""Hydrocortisone related to Insulin resistance"". The statement discusses correlations between various markers in endotoxin-treated dogs, one of which is cortisol (a stress hormone that can be converted into hydrocortisone in humans). However, there is no mention or implication of insulin resistance in the statement. Insulin resistance would involve a decreased response to insulin in cells, leading to high blood glucose levels, which is not mentioned in the provided statement. Therefore, while cortisol (and potentially hydrocortisone) may be related to endotoxin response in dogs, no conclusions can be drawn about its relationship with insulin resistance based on this information alone." -7919367,Hydrocortisone related to adrenocortical insufficiency,383,Contribution of cortisol deficiency to septic shock.,True,Is the triple 'Hydrocortisone related to adrenocortical insufficiency' supported by the sentence: 'Contribution of cortisol deficiency to septic shock.'?,"Yes, there is indirect support for the phrase ""Hydrocortisone related to adrenocortical insufficiency"" from the statement ""Contribution of cortisol deficiency to septic shock."" + In summary, while it is true that certain glucocorticoids like hydrocortisone can cause insulin resistance due to their effects on glucose metabolism, the provided statement does not offer any support for that relationship because it focuses on triamcinol" +7432490,Hydrocortisone causes pancreatitis,407,OBJECTIVE: To validate the responsiveness of cerebrospinal fluid (CSF) inflammatory biomarkers to treatment with natalizumab and methylprednisolone in progressive MS and to examine the relationship between CSF inflammatory and tissue damage biomarkers.,False,"'Does the phrase ""Hydrocortisone causes pancreatitis"" receive at least indirect support from the statement: ""OBJECTIVE: To validate the responsiveness of cerebrospinal fluid (CSF) inflammatory biomarkers to treatment with natalizumab and methylprednisolone in progressive MS and to examine the relationship between CSF inflammatory and tissue damage biomarkers.""?","No, the statement does not provide indirect support for the phrase ""Hydrocortisone causes pancreatitis."" The objective of the study mentioned is to validate the responsiveness of cerebrospinal fluid (CSF) inflammatory biomarkers to treatment with natalizumab and methylprednisolone in progressive MS (Multiple Sclerosis) and to examine the relationship between CSF inflammatory and tissue damage biomarkers. Methylprednisolone is a type of steroid often used in treating MS flares, but there is no mention of hydrocortisone in the statement provided. - - Justification: + Moreover, even if hydrocortisone were mentioned in the study, it would not automatically imply that hydrocortisone causes pancreatitis. To establish such a causal link, there would need to be evidence showing that hydrocortisone administration results in an increased incidence of pancreatitis compared to placebo or no treatment in controlled studies specifically designed to test that hypothesis. - - Hydrocortisone is a synthetic glucocorticoid hormone that is often used as replacement therapy for adrenocortical insufficiency (also known as Addison’s disease), which is characterized by impaired cortisol secretion from the adrenal glands [1]. Cortisol is a vital stress hormone that helps regulate metabolism and immune response [2]. + In summary, there is no indirect support for ""Hydrocortisone causes pancreatitis"" in the provided statement because hydrocortis" +26997315,Hydrocortisone affects congenital adrenal hyperplasia,408,The region was identified as a significant predictor of use of intravenous methylprednisolone in MCD and MN patients.,False,"'Does the phrase ""Hydrocortisone affects congenital adrenal hyperplasia"" receive at least indirect support from the statement: ""The region was identified as a significant predictor of use of intravenous methylprednisolone in MCD and MN patients.""?","No, the statement does not provide indirect support for the phrase ""Hydrocortisone affects congenital adrenal hyperplasia."" The statement refers to intravenous methylprednisolone use in MCD (Minimal Change Disease) and MN (Membranous Nephropathy) patients, not hydrocortisone use in congenital adrenal hyperplasia patients. Hydrocortisone and methylprednisolone are both corticosteroids but they have different therapeutic indications and effects on various medical conditions. Congenital adrenal hyperplasia is primarily treated with hydrocortisone due to its glucocorticoid activity, whereas methylprednisolone is used more often in nephrotic syndrome associated with MCD and MN due to its mineralocorticoid-sparing properties. Therefore, these two statements do not have any direct or indirect correlation in terms of their clinical implications and disease contexts." +26940919,Hydrocortisone affects cardiac arrest,409,"Clinical commentary on ""Two cases of anaphylactic shock by methylprednisolone in neuromyelitis optica"".",False,"'Does the phrase ""Hydrocortisone affects cardiac arrest"" receive at least indirect support from the statement: ""Clinical commentary on ""Two cases of anaphylactic shock by methylprednisolone in neuromyelitis optica"".""?","No, the statement ""Clinical commentary on 'Two cases of anaphylactic shock by methylprednisolone in neuromyelitis optica'"" does not provide indirect support for the phrase ""Hydrocortisone affects cardiac arrest."" Methylprednisolone is a synthetic glucocorticoid used primarily for its anti-inflammatory effects, while hydrocortisone is also a corticosteroid used to treat various conditions such as inflammation and allergic reactions. Although both drugs belong to the same class of medications (corticosteroids), they have different chemical structures and therapeutic indications. - - The statement ""Contribution of cortisol deficiency to septic shock"" implies that cortisol plays an essential role in managing septic shock, which is a severe complication of sepsis that can lead to multi-organ failure [3]. In cases of septic shock, corticosteroids like hydrocortisone can be administered as part of treatment due to their ability to modulate immune response and improve hemodynamic stability [4]. + The clinical commentary focuses on two cases of anaphylactic shock caused by methylprednisolone in neuromyelitis optica patients. The text does not mention hydrocortisone or its potential effects on cardiac arrest. Even if it did discuss hydrocortisone, anecdotal evidence from case reports should be interpreted cautiously since they do not provide robust evidence of cause-and-effect relationships due to confounding factors, small sample sizes, and potential publication bias. + + Therefore, there is no indirect" +26840479,Hydrocortisone affects myocardial infarction,410,CONCLUSION: Results show that inhalation of budesonide (2 mg 3 times/day) and systemic methylprednisolone (40 mg/day) had similar clinical outcome in AECOPD.,False,"'Does the phrase ""Hydrocortisone affects myocardial infarction"" receive at least indirect support from the statement: ""CONCLUSION: Results show that inhalation of budesonide (2 mg 3 times/day) and systemic methylprednisolone (40 mg/day) had similar clinical outcome in AECOPD.""?","No, the statement does not provide indirect support for the phrase ""Hydrocortisone affects myocardial infarction."" The conclusion provided in the statement is related to a study on Chronic Obstructive Pulmonary Disease (COPD) exacerbations (AECOPD), where two different treatments (budesonide inhalation and systemic methylprednisolone) were compared in terms of their clinical outcomes. Hydrocortisone is not mentioned in the study or conclusion at all; therefore, it is not possible to draw any conclusions about its effect on myocardial infarction based on this information alone. - Therefore, since" -7573954,Hydrocortisone related to neoplasm,384,The objective of this study was to demonstrate the effect of stress doses of hydrocortisone during the initial phase of human septic shock on the serum values of the neurospecific protein S-100B in comparison to the inflammation markers interleukin (IL)-8 in serum and polymorphonuclear (PMN) elastase in plasma.,False,Is the triple 'Hydrocortisone related to neoplasm' supported by the sentence: 'The objective of this study was to demonstrate the effect of stress doses of hydrocortisone during the initial phase of human septic shock on the serum values of the neurospecific protein S-100B in comparison to the inflammation markers interleukin (IL)-8 in serum and polymorphonuclear (PMN) elastase in plasma.'?,"No, the statement does not provide indirect support for the phrase ""Hydrocortisone related to neoplasm"". The objective of the study as described is focused on understanding the impact of stress doses of hydrocortisone on serum values of S-100B protein, IL-8 in serum, and PMN elastase in plasma during the initial phase of human septic shock. There is no mention or implication of neoplasm (abnormal growth of cells) in relation to hydrocortisone in this study." -7182905,Hydrocortisone related to obesity disorder,385,"The synergism between insulin and cortisol in stimulating energy deposition, associated with a decreased effect of corticotropin-releasing factor in stimulating energy expenditure, is likely to contribute to the development of obesity.",True,"Is the triple 'Hydrocortisone related to obesity disorder' supported by the sentence: 'The synergism between insulin and cortisol in stimulating energy deposition, associated with a decreased effect of corticotropin-releasing factor in stimulating energy expenditure, is likely to contribute to the development of obesity.'?","Yes, indirectly it does support the phrase ""Hydrocortisone related to obesity disorder"". Hydrocortisone is a type of cortisol, which is mentioned in the statement as having an interaction with insulin in relation to obesity development. The statement explains that cortisol stimulates energy deposition (which can contribute to obesity) and decreases the effect of corticotropin-releasing factor in stimulating energy expenditure (which can also contribute to obesity). Therefore, increased hydrocortisone levels could potentially contribute to obesity development due to these mechanisms mentioned in the statement." -24445107,Hydrocortisone related to Inflammation,386,Higher basal cortisol predicts verbal memory loss in postmenopausal women: Rancho Bernardo Study.,True,Is the triple 'Hydrocortisone related to Inflammation' supported by the sentence: 'Higher basal cortisol predicts verbal memory loss in postmenopausal women: Rancho Bernardo Study.'?,"Yes, there is indirect support for the phrase ""Hydrocortisone related to Inflammation"" in the statement ""Higher basal cortisol predicts verbal memory loss in postmenopausal women: Rancho Bernardo Study."" - Hydrocortisone is a type of cortisol hormone produced by the adrenal glands in response to stress. Cortisol has been shown to have immunosuppressive effects, including reducing inflammation in the body (Munck et al., 1984). The Rancho Bernardo Study found that higher basal cortisol (which includes hydrocortisone) levels predict verbal memory loss in postmenopausal women (Lupien et al., 1998). + The statement only provides evidence for the clinical outcomes of budesonide inhalation and systemic methylprednisolone in AECOPD patients; hence it does not contribute any knowledge regarding hydrocortisone's impact on myocardial infarction. Hydrocortisone is a different medication that belongs to the same class of drugs as methylprednisolone (glucocorticoids), but their specific effects on various conditions might differ due to differences in pharmacokinetics" +24701128,Hydrocortisone affects Sepsis,411,A Clinical Trial Comparing the Safety and Efficacy of Topical Tacrolimus versus Methylprednisolone in Ocular Graft-versus-Host Disease.,False,"'Does the phrase ""Hydrocortisone affects Sepsis"" receive at least indirect support from the statement: ""A Clinical Trial Comparing the Safety and Efficacy of Topical Tacrolimus versus Methylprednisolone in Ocular Graft-versus-Host Disease.""?","No, the statement ""A Clinical Trial Comparing the Safety and Efficacy of Topical Tacrolimus versus Methylprednisolone in Ocular Graft-versus-Host Disease"" does not provide indirect support for the phrase ""Hydrocortisone affects Sepsis."" - Although this study does not explicitly investigate hydrocortisone or inflammation, it does suggest that cortisol levels—and by extension hydrocortisone—are associated with cognitive decline in postmenopausal women. This finding is relevant because chronic inflammation is known to contribute to cognitive decline in older adults (Mrak & Griffin, 2005). Thus" -24030854,Hydrocortisone related to Hypoxemia,387,"A growing body of evidence now suggests that endogenous cortisol, which is produced in significant quantities by the body in a diurnal rhythm, is an important regulator of allergic disease expression and allergic inflammatory responses: lung function varies along with plasma cortisol levels; the number of circulating inflammatory cells varies with plasma cortisol levels; and low levels of endogenous cortisol may be associated with risk for asthma.",False,"Is the triple 'Hydrocortisone related to Hypoxemia' supported by the sentence: 'A growing body of evidence now suggests that endogenous cortisol, which is produced in significant quantities by the body in a diurnal rhythm, is an important regulator of allergic disease expression and allergic inflammatory responses: lung function varies along with plasma cortisol levels; the number of circulating inflammatory cells varies with plasma cortisol levels; and low levels of endogenous cortisol may be associated with risk for asthma.'?","No, the statement does not provide direct or indirect support for the phrase ""Hydrocortisone related to Hypoxemia."" + The clinical trial mentioned is focused on comparing the safety and efficacy of two different treatments (topical tacrolimus and methylprednisolone) for ocular graft-versus-host disease. Hydrocortisone is not one of the treatments being compared in this trial, nor is sepsis mentioned as an outcome of interest. Therefore, there is no clear connection between the clinical trial and the claim about hydrocortisone affecting sepsis. - The statement discusses the role of endogenous cortisol in allergic disease expression and inflammatory responses, particularly in lung function and circulating inflammatory cells. Hydrocortisone is a synthetic form of cortisol, a glucocorticoid hormone, which is often used as a medication to reduce inflammation in various conditions such as asthma, arthritis, and dermatologic diseases. + However, it is important to note that hydrocortisone is a type of corticosteroid, like methylprednisolone, which was used in the trial. Both drugs have anti-inflammatory effects, and hydrocortisone is sometimes used in the treatment of sepsis due to its potential to reduce inflammation. But the absence of hydrocort" +21274202,Hydrocortisone affects osteoarthritis,412,The purpose of this study was to evaluate the efficacy of supraperiosteal injection of methylprednisolone compared with an oral tablet form and intravenous (i.v.) injection in the prevention of postoperative pain and oedema associated with inflammation.,False,"'Does the phrase ""Hydrocortisone affects osteoarthritis"" receive at least indirect support from the statement: ""The purpose of this study was to evaluate the efficacy of supraperiosteal injection of methylprednisolone compared with an oral tablet form and intravenous (i.v.) injection in the prevention of postoperative pain and oedema associated with inflammation.""?","No, the statement does not provide indirect support for the phrase ""Hydrocortisone affects osteoarthritis"". The study mentioned in the statement is focused on comparing different methods of administering methylprednisolone for preventing postoperative pain and edema associated with inflammation. Hydrocortisone is not mentioned in the study statement at all, let alone its effects on osteoarthritis. Therefore, it is not appropriate to draw any conclusions about hydrocortisone's effects on osteoarthritis based on the provided statement alone." +20701310,Hydrocortisone affects psoriasis,413,Gamma globulin and methylprednisolone in idiopathic thrombocytopenic purpura.,False,"'Does the phrase ""Hydrocortisone affects psoriasis"" receive at least indirect support from the statement: ""Gamma globulin and methylprednisolone in idiopathic thrombocytopenic purpura.""?","No, the statement ""Gamma globulin and methylprednisolone in idiopathic thrombocytopenic purpura"" does not provide indirect support for the claim that ""Hydrocortisone affects psoriasis."" - Hypoxemia refers to lower-than-normal levels of oxygen in the blood. While hydrocortisone could potentially impact oxygen levels indirectly by modulating inflammation in lung tissue (which might affect gas exchange), there is no explicit connection made between hydrocortisone and hypoxemia in either the provided statement or general medical knowledge. + The statement given discusses two treatments (gamma globulin and methylprednisolone) used for idiopathic thrombocytopenic purpura (ITP), a condition characterized by an abnormally low platelet count in the blood. Methylprednisolone is a type of corticosteroid like hydrocortisone; however, they are not identical substances and their effects on different conditions may vary significantly. - Therefore, further investigation would be required to establish any potential relationship between hydrocortisone use and hypoxemia risk." -12533519,Hydrocortisone related to Insulin resistance,388,"In conclusion, the data presented here suggest that cortisol can contribute to insulin resistance in ponies with hyperlipoproteinaemia.",True,"Is the triple 'Hydrocortisone related to Insulin resistance' supported by the sentence: 'In conclusion, the data presented here suggest that cortisol can contribute to insulin resistance in ponies with hyperlipoproteinaemia.'?","Yes, the statement ""In conclusion, the data presented here suggest that cortisol can contribute to insulin resistance in ponies with hyperlipoproteinaemia"" does lend indirect support to the phrase ""Hydrocortisone related to Insulin resistance"". + Psoriasis is an autoimmune condition that causes skin cells to grow too quickly, leading to thickened patches of red skin covered in silvery scales. While it is true that corticosteroids like hydrocortisone can be used in treating psoriasis due to their anti-inflammatory properties, it does not follow that just because methylprednisolone is used in treating ITP that hydrocortisone would have similar effects on p" +20336537,Hydrocortisone affects dermatitis,414,Methylprednisolone and hepatotoxicity in Graves' ophthalmopathy.,False,"'Does the phrase ""Hydrocortisone affects dermatitis"" receive at least indirect support from the statement: ""Methylprednisolone and hepatotoxicity in Graves' ophthalmopathy.""?","No, the statement ""Methylprednisolone and hepatotoxicity in Graves' ophthalmopathy"" does not provide indirect support for the claim that ""Hydrocortisone affects dermatitis."" - Hydrocortisone is a synthetic form of cortisol, a glucocorticoid hormone that is naturally produced in humans and animals. Cortisol is known to have various metabolic effects, including increasing blood glucose levels and potentially contributing to insulin resistance. + The reason is that these two statements discuss different corticosteroids (Hydrocortisone and Methylprednisolone) and different medical conditions (dermatitis and Graves' ophthalmopathy). Although both Hydrocortisone and Methylprednisolone belong to the class of corticosteroids that have anti-inflammatory properties and can be used in treating various medical conditions, they have distinct pharmacological profiles that may lead to different therapeutic effects as well as side effects. - The study in question suggests that cortisol can contribute to insulin resistance in ponies with hyperlipoproteinaemia. Given that hydrocortisone is a synthetic form of cortisol, it stands to reason that hydrocortisone could also contribute to insulin resistance under similar circumstances. However, it is important to note that this is an indirect inference, as the study does not explicitly test the effects of hydrocortisone on insulin resistance. Further studies would be needed to confirm this relationship specifically for hydrocortisone." -27747116,Hydrocortisone causes toxic shock syndrome,389,"OBJECTIVE: To investigate the relationship of cortisol concentrations during the first week of life to patent ductus arteriosus (PDA), markers of lung inflammation, and respiratory outcome in very low birth weight infants.",False,"Is the triple 'Hydrocortisone causes toxic shock syndrome' supported by the sentence: 'OBJECTIVE: To investigate the relationship of cortisol concentrations during the first week of life to patent ductus arteriosus (PDA), markers of lung inflammation, and respiratory outcome in very low birth weight infants.'?","No, the statement does not provide indirect support for the phrase ""Hydrocortisone causes toxic shock syndrome."" The objective is investigating cortisol concentrations in relation to PDA, lung inflammation markers, and respiratory outcome in very low birth weight infants. Hydrocortisone is not mentioned in the objective nor is there any connection made between it and toxic shock syndrome in the statement provided." -27747115,Hydrocortisone causes Sepsis,390,Oral pH-modified release budesonide versus 6-methylprednisolone in active Crohn's disease.,False,Is the triple 'Hydrocortisone causes Sepsis' supported by the sentence: 'Oral pH-modified release budesonide versus 6-methylprednisolone in active Crohn's disease.'?,"No, the statement ""Oral pH-modified release budesonide versus 6-methylprednisolone in active Crohn's disease"" does not provide indirect support for the claim that ""Hydrocortisone causes Sepsis."" This study compares two treatments for Crohn's disease - an oral pH-modified release formulation of budesonide and 6-methylprednisolone - but it does not mention hydrocortisone nor make any connection between these treatments and sepsis development. Hydrocortisone is a type of corticosteroid hormone used in various medical treatments; however, its use does not inherently imply sepsis as an outcome. Sepsis is typically caused by an overwhelming immune response to an infection rather than direct administration of corticosteroids such as hydrocortisone." -27073884,Hydrocortisone causes atopic eczema,391,Pharmacokinetics of high dose methylprednisolone and use in hematological malignancies.,False,Is the triple 'Hydrocortisone causes atopic eczema' supported by the sentence: 'Pharmacokinetics of high dose methylprednisolone and use in hematological malignancies.'?,"No, the statement ""Pharmacokinetics of high dose methylprednisolone and use in hematological malignancies"" does not provide any direct or indirect support for the claim that ""Hydrocortisone causes atopic eczema"". The two statements discuss different topics: one is about pharmacokinetics (the absorption, distribution, metabolism, and excretion) of methylprednisolone in high doses in relation to hematological malignancies (cancers affecting blood cells), while the other is about hydrocortisone potentially causing atopic eczema (a chronic inflammatory skin condition). + In addition, Graves' ophthalmopathy is an eye condition related to Graves' disease (an autoimmune disorder that causes hyperthyroidism), while dermatitis is an inflammation of the skin that can be caused by various factors such as allergies, irritants, genetics, infections, or autoimmune conditions. - To support the claim that ""Hydrocortisone causes atopic eczema"", evidence would need to show that hydrocortisone exposure leads to an increased likelihood of developing atopic eczema. The statement about methylprednisolone does not provide any information about hydrocortisone, its pharmacological properties, or its potential effects on atopic eczema. Therefore, it cannot be used as support for that claim." -25383174,Hydrocortisone causes fibromyalgia,392,"Methylprednisolone in advanced chronic lymphocytic leukaemia: rationale for, and effectiveness of treatment suggested by DiSC assay.",False,"Is the triple 'Hydrocortisone causes fibromyalgia' supported by the sentence: 'Methylprednisolone in advanced chronic lymphocytic leukaemia: rationale for, and effectiveness of treatment suggested by DiSC assay.'?","No, the statement does not provide any indirect support for the claim that hydrocortisone causes fibromyalgia. The two statements discuss different topics: one is about methylprednisolone treatment in advanced chronic lymphocytic leukaemia, while the other is about hydrocortisone potentially causing fibromyalgia. + Therefore, without further evidence link" +20137862,Hydrocortisone affects fibromyalgia,415,"In orthognathic surgery, methylprednisolone > or =85 mg administered intravenously seemed sufficient to produce a significant decrease in edema, and several trials pointed toward a neuroregeneration effect, but no statistical analysis could be performed.",False,"'Does the phrase ""Hydrocortisone affects fibromyalgia"" receive at least indirect support from the statement: ""In orthognathic surgery, methylprednisolone > or =85 mg administered intravenously seemed sufficient to produce a significant decrease in edema, and several trials pointed toward a neuroregeneration effect, but no statistical analysis could be performed.""?","No, the statement does not provide indirect support for the phrase ""Hydrocortisone affects fibromyalgia."" The statement discusses the effects of methylprednisolone in orthognathic surgery, not hydrocortisone in fibromyalgia. Methylprednisolone is a synthetic glucocorticoid used in medical practice similarly to hydrocortisone, but they are distinct drugs that may have different therapeutic profiles and effects in various conditions. Fibromyalgia is also distinct from edema associated with orthognathic surgery. Therefore, drawing any conclusions about hydrocortisone's impact on fibromyalgia based on the provided statement would be inappropriate and misleading." +19555227,Hydrocortisone affects pneumonia,416,Response of symptoms and synovitis to intra-muscular methylprednisolone in osteoarthritis of the hand: an ultrasonographic study.,False,"'Does the phrase ""Hydrocortisone affects pneumonia"" receive at least indirect support from the statement: ""Response of symptoms and synovitis to intra-muscular methylprednisolone in osteoarthritis of the hand: an ultrasonographic study.""?","No, the statement ""Response of symptoms and synovitis to intra-muscular methylprednisolone in osteoarthritis of the hand: an ultrasonographic study"" does not provide indirect support for the claim that ""Hydrocortisone affects pneumonia."" - Furthermore, these two steroids have different properties and uses in medicine; therefore, there is no logical connection between their effects on patients. Methylprednisolone is primarily used as an anti-inflammatory drug in various conditions like arthritis and allergies, while hydrocortisone is used as both an anti-inflammatory drug as well as replacement therapy in adrenal insufficiency. + The reason for this is that methylprednisolone is a synthetic glucocorticoid used primarily for its anti-inflammatory effects, while hydrocortisone is also a glucocorticoid but it is primarily used for its anti-stress and immunosuppressive effects. Both are used in treating various conditions, but they are not interchangeable in all contexts. - The statement only implies that methylprednisolone may be an effective treatment for advanced chronic lymphocytic leukaemia based on DiSC assay results; it does not suggest any connection between steroid use (including hydrocortisone) and fibromyalgia development. Fibromyalgia is considered a disorder of pain regulation with complex interactions between genetic, environmental," -25205462,Hydrocortisone causes hypotensive disorder,393,The effects of intravenous pulse methylprednisolone on immunological and inflammatory processes in ankylosing spondylitis.,False,Is the triple 'Hydrocortisone causes hypotensive disorder' supported by the sentence: 'The effects of intravenous pulse methylprednisolone on immunological and inflammatory processes in ankylosing spondylitis.'?,"No, the statement does not provide indirect support for the phrase ""Hydrocortisone causes hypotensive disorder."" The statement discusses the effects of intravenous pulse methylprednisolone on immunological and inflammatory processes in ankylosing spondylitis, which is unrelated to Hydrocortisone or hypotensive disorder. Hydrocortisone is a different glucocorticoid medication than methylprednisolone; therefore, any potential effects on blood pressure would need separate evaluation. Additionally, hypotensive disorder refers to abnormally low blood pressure, not high blood pressure as might be more commonly associated with corticosteroids like Hydrocortisone." -20591759,Hydrocortisone causes Hypoxemia,394,The effect of methylprednisolone (MP) on the cell kinetic response to cyclophosphamide (CP) and Adriamycin (ADR) in C3H/HeJ spontaneous mammary tumors and hematopoietic tissue was investigated.,False,Is the triple 'Hydrocortisone causes Hypoxemia' supported by the sentence: 'The effect of methylprednisolone (MP) on the cell kinetic response to cyclophosphamide (CP) and Adriamycin (ADR) in C3H/HeJ spontaneous mammary tumors and hematopoietic tissue was investigated.'?,"No, the statement does not provide indirect support for the claim that ""Hydrocortisone causes Hypoxemia."" The study mentioned in the statement investigates the effect of methylprednisolone (MP) on cyclophosphamide (CP) and Adriamycin (ADR) in C3H/HeJ spontaneous mammary tumors and hematopoietic tissue. Hydrocortisone is not mentioned in the study, and there is no information linking it to hypoxemia (a condition characterized by low levels of oxygen in the blood) in this context." -18446972,Hydrocortisone causes congenital adrenal hyperplasia,395,High-dose intravenous methyl-prednisolone in chronic polymyositis/dermatomyositis.,False,Is the triple 'Hydrocortisone causes congenital adrenal hyperplasia' supported by the sentence: 'High-dose intravenous methyl-prednisolone in chronic polymyositis/dermatomyositis.'?,"No, the statement does not provide indirect support for the phrase ""Hydrocortisone causes congenital adrenal hyperplasia."" The statement discusses high-dose intravenous methyl-prednisolone used in treating chronic polymyositis/dermatomyositis, which is unrelated to Hydrocortisone or congenital adrenal hyperplasia (CAH). + Furthermore, the study in question focuses on osteoarthritis of the hand, which is a degenerative joint disease, not pneumonia. The fact that symptoms and synovitis (inflammation of the synovial membrane) responded to intra-muscular methylprednisolone in this context does not provide any evidence or indication that hydrocortisone would have similar effects on pneumonia. - CAH is primarily caused by genetic mutations affecting enzymes in steroid biosynthesis pathways in the adrenal glands; it is not caused by exposure to Hydrocortisone or other glucocorticoids during treatment for other conditions. + Therefore," +19531871,Hydrocortisone affects atrial fibrillation,417,Long-term results of high-dose methylprednisolone in aplastic anemia.,False,"'Does the phrase ""Hydrocortisone affects atrial fibrillation"" receive at least indirect support from the statement: ""Long-term results of high-dose methylprednisolone in aplastic anemia.""?","No, the statement ""Long-term results of high-dose methylprednisolone in aplastic anemia"" does not provide indirect support for the phrase ""Hydrocortisone affects atrial fibrillation."" - However, glucocorticoids like Hydrocortisone may affect fetal development when taken during pregnancy due to their ability to cross the placenta; they may increase the risk for certain complications such as preterm birth and low birth weight but not congenital adrenal hyperplasia specifically. + The two statements are not related in terms of their subject matter. Methylprednisolone is a synthetic glucocorticoid, while hydrocortisone is a natural glucocorticoid; both have anti-inflammatory properties but they are not interchangeable in terms of their effects on various conditions. Aplastic anemia is a condition characterized by pancytopenia (a decrease in all types of blood cells), which is not directly related to atrial fibrillation (a type of irregular heart rhythm). Therefore, the long-term results of high-dose methylprednisolone in aplastic anemia do not provide any insight into how hydrocortisone might affect atrial fibrillation. - Therefore, it is crucial to differentiate between causation (Hydrocortisone causing CAH) and potential associations (Hydrocort" -18240145,Hydrocortisone causes injury,396,Comparing Intratympanic Gentamicin with Methylprednisolone in Meniere's Disease with Non-Serviceable Hearing.,False,Is the triple 'Hydrocortisone causes injury' supported by the sentence: 'Comparing Intratympanic Gentamicin with Methylprednisolone in Meniere's Disease with Non-Serviceable Hearing.'?,"No, the statement ""Comparing Intratympanic Gentamicin with Methylprednisolone in Meniere's Disease with Non-Serviceable Hearing"" does not provide indirect support for the phrase ""Hydrocortisone causes injury."" The statement discusses a comparison between Intratympanic Gentamicin and Methylprednisolone in Meniere's Disease with Non-Serviceable Hearing. Hydrocortisone is not mentioned in this statement; therefore, it cannot provide indirect support for any claim about Hydrocortisone causing injury. + It is important to note that while both methylprednisolone and hydrocortisone belong to the class of drugs known as glucoc" +18495054,Hydrocortisone affects lymphoma,418,"Efficacy of methylprednisolone, cyclophosphamide in pediatric IgA nephropathy assessed by renal biopsy.",False,"'Does the phrase ""Hydrocortisone affects lymphoma"" receive at least indirect support from the statement: ""Efficacy of methylprednisolone, cyclophosphamide in pediatric IgA nephropathy assessed by renal biopsy.""?","No, the statement does not provide indirect support for the phrase ""Hydrocortisone affects lymphoma."" The statement discusses the efficacy of methylprednisolone and cyclophosphamide in pediatric IgA nephropathy, which is a kidney disease. Hydrocortisone is a type of corticosteroid like methylprednisolone, but they are not identical drugs. Furthermore, IgA nephropathy is not lymphoma. Therefore, even if the statement were about hydrocortisone instead of methylprednisolone, it would still not provide indirect support for the claim about lymphoma because the disease context is different." +18495053,Hydrocortisone affects leukemia,419,"The impaired effect on lymphocyte blastogenesis of glucocorticoids administered in vivo, in contrast to a normal in vitro reaction to dexamethasone, together with recent findings of an altered glucocorticoid receptor pharmacology in AD, points to a decreased biological in vivo efficiency of methylprednisolone in atopic dermatitis.",False,"'Does the phrase ""Hydrocortisone affects leukemia"" receive at least indirect support from the statement: ""The impaired effect on lymphocyte blastogenesis of glucocorticoids administered in vivo, in contrast to a normal in vitro reaction to dexamethasone, together with recent findings of an altered glucocorticoid receptor pharmacology in AD, points to a decreased biological in vivo efficiency of methylprednisolone in atopic dermatitis.""?","No, the statement does not provide direct or indirect support for the phrase ""Hydrocortisone affects leukemia."" The statement discusses the in vivo efficiency of glucocorticoids, specifically methylprednisolone, in atopic dermatitis (AD). It makes no mention of hydrocortisone or leukemia. - However, it is important to note that Hydrocortisone is a type of corticosteroid, similar to Methylprednisolone, which is mentioned in the statement. Corticosteroids have been associated with various side effects such as increased risk for infections, osteoporosis, diabetes mellitus, hypertension, psychological effects among others when used systemically (Boumpas et al., 1993). But these potential adverse effects do not necessarily translate into ""injury"" in every context. + Hydrocortisone is a type of glucocorticoid often used in treating various conditions due to its anti-inflammatory effects. Leukemia is a type of cancer that affects blood cells. While glucocorticoids like hydrocortisone can impact lymphocytes (a type of white blood cell), which may be relevant in leukemia treatment, the statement does not provide any information about such an effect. - In conclusion, while cortic" -17359303,Hydrocortisone causes influenza,397,"High-dose methylprednisolone, vincristine, MTX, and ara-C (SOMA) as initial bulk reducing therapy in non-Hodgkin's lymphoma of unfavorable histology: preliminary results of an ongoing phase II study.",False,"Is the triple 'Hydrocortisone causes influenza' supported by the sentence: 'High-dose methylprednisolone, vincristine, MTX, and ara-C (SOMA) as initial bulk reducing therapy in non-Hodgkin's lymphoma of unfavorable histology: preliminary results of an ongoing phase II study.'?","No, the statement does not provide any indirect support for the claim that ""Hydrocortisone causes influenza."" The statement discusses initial bulk reducing therapy in non-Hodgkin's lymphoma using high-dose methylprednisolone along with other drugs. There is no mention or implication of hydrocortisone causing influenza in either the original claim or in general medical knowledge. Influenza is caused by viruses, not by hydrocortisone or other steroid medications like methylprednisolone." -13585273,"Hydrocortisone causes dermatitis, atopic",398,A Prospective Study Comparing the Efficacy of Local Injection of Platelet-Rich Plasma (PRP) vs Methylprednisolone in Plantar Fasciitis.,False,"Is the triple 'Hydrocortisone causes dermatitis, atopic' supported by the sentence: 'A Prospective Study Comparing the Efficacy of Local Injection of Platelet-Rich Plasma (PRP) vs Methylprednisolone in Plantar Fasciitis.'?","No, the statement does not provide direct or indirect support for the claim that ""Hydrocortisone causes dermatitis, atopic."" The study in question compares the efficacy of PRP injections versus methylprednisolone injections for treating plantar fasciitis. Hydrocortisone is not mentioned in the study title or abstract provided. + Therefore, without additional evidence linking hydrocortisone to leukemia, it is not reasonable to infer that hydrocortisone has an effect on leukemia based on this statement alone." +18310128,Hydrocortisone affects toxic shock syndrome,420,"CONCLUSION: In this single-center trial, combined vasopressin-epinephrine and methylprednisolone during resuscitation and stress-dose hydrocortisone in postresuscitation shock improved survival in refractory in-hospital cardiac arrest.",True,"'Does the phrase ""Hydrocortisone affects toxic shock syndrome"" receive at least indirect support from the statement: ""CONCLUSION: In this single-center trial, combined vasopressin-epinephrine and methylprednisolone during resuscitation and stress-dose hydrocortisone in postresuscitation shock improved survival in refractory in-hospital cardiac arrest.""?","Yes, indirectly. The statement does not specifically mention toxic shock syndrome but it does suggest that hydrocortisone (a type of steroid) can improve survival in refractory in-hospital cardiac arrest when used in postresuscitation shock. This implies that hydrocortisone could potentially have beneficial effects in severe shock states, which could theoretically include toxic shock syndrome. However, it is important to note that toxic shock syndrome is a complex condition often caused by bacterial infections, and it would require further specific research to determine if hydrocortisone would be beneficial in that context." +17910566,Hydrocortisone affects atopic eczema,421,Weekly bortezomib/methylprednisolone is effective and well tolerated in relapsed multiple myeloma.,False,"'Does the phrase ""Hydrocortisone affects atopic eczema"" receive at least indirect support from the statement: ""Weekly bortezomib/methylprednisolone is effective and well tolerated in relapsed multiple myeloma.""?","No, the statement does not provide indirect support for the phrase ""Hydrocortisone affects atopic eczema."" The statement discusses the effectiveness and tolerability of weekly bortezomib/methylprednisolone in relapsed multiple myeloma, which does not make any reference to hydrocortisone or atopic eczema. Hydrocortisone is a type of corticosteroid often used in treating various skin conditions including atopic eczema; however, without explicit mention of hydrocortisone in relation to atopic eczema in the provided statement, it cannot lend indirect support for that specific claim." +15925719,Hydrocortisone affects Inflammation,422,Amsacrine combined with etoposide and high-dose methylprednisolone as salvage therapy in acute lymphoblastic leukemia in children.,False,"'Does the phrase ""Hydrocortisone affects Inflammation"" receive at least indirect support from the statement: ""Amsacrine combined with etoposide and high-dose methylprednisolone as salvage therapy in acute lymphoblastic leukemia in children.""?","No, the statement does not provide direct or indirect support for the phrase ""Hydrocortisone affects Inflammation."" The statement discusses a therapeutic approach for acute lymphoblastic leukemia in children using Amsacrine, etoposide, and high-dose methylprednisolone. Methylprednisolone is a type of corticosteroid like hydrocortisone, but they have different pharmacological properties and uses. The statement does not mention hydrocortisone nor provide any information about its potential impact on inflammation." +14970164,Hydrocortisone affects Insulin resistance,423,Controlled clinical trial of IV cyclophosphamide versus IV methylprednisolone in severe neurological manifestations in systemic lupus erythematosus.,False,"'Does the phrase ""Hydrocortisone affects Insulin resistance"" receive at least indirect support from the statement: ""Controlled clinical trial of IV cyclophosphamide versus IV methylprednisolone in severe neurological manifestations in systemic lupus erythematosus.""?","No, the statement does not provide indirect support for the phrase ""Hydrocortisone affects Insulin resistance."" The clinical trial mentioned in the statement compares two treatments for severe neurological manifestations in systemic lupus erythematosus (SLE), one of which involves methylprednisolone, a glucocorticoid like hydrocortisone. However, insulin resistance is not mentioned or investigated in the context of this trial, so no conclusions can be drawn about hydrocortisone's effect on insulin resistance from this information alone." +14804311,Hydrocortisone affects injury,424,Delayed hypersensitivity to 6-methyl-prednisolone in Henoch Schoenlein syndrome.,False,"'Does the phrase ""Hydrocortisone affects injury"" receive at least indirect support from the statement: ""Delayed hypersensitivity to 6-methyl-prednisolone in Henoch Schoenlein syndrome.""?","No, the statement ""Delayed hypersensitivity to 6-methyl-prednisolone in Henoch Schoenlein syndrome"" does not provide direct or indirect support for the phrase ""Hydrocortisone affects injury."" - To further elaborate on why there is no support for the claim: + - - The study focuses on comparing two treatments for plantar fasciitis, PRP injections and methylprednisolone injections. - - Hydrocortisone is not mentioned as either a treatment option or an adverse effect in the study title or abstract. - - Hydrocortisone is chemically distinct from methylprednisolone; therefore, any potential adverse effects would not necessarily be shared between these two compounds. - - Dermatitis is not mentioned as an adverse effect for either treatment in the study title or abstract. + The statement refers specifically to delayed hypersensitivity (an allergic reaction) to 6-methyl-prednisolone, which is a synthetic glucocorticoid similar to hydrocortisone but not identical. Hydrocortisone is also a glucocorticoid, but it is not explicitly mentioned in the statement. Furthermore, the statement discusses an allergic reaction, not an injury. Therefore, there is no clear connection between the two phrases in terms of topic or content. - In conclusion, there is no indirect support for the claim that ""Hydrocortisone causes dermatitis, atopic"" based on the provided" -12645476,Hydrocortisone causes obesity disorder,399,A controlled trial of 6-methylprednisolone in acute alcoholic hepatitis.,False,Is the triple 'Hydrocortisone causes obesity disorder' supported by the sentence: 'A controlled trial of 6-methylprednisolone in acute alcoholic hepatitis.'?,"No, the statement ""A controlled trial of 6-methylprednisolone in acute alcoholic hepatitis"" does not provide indirect support for the phrase ""Hydrocortisone causes obesity disorder."" + - The reason is that 6-methylprednisolone is not hydrocortisone, although they both belong to the class of steroid hormones known as glucocorticoids. While glucocorticoids can have various side effects including weight gain due to increased appetite, water retention, and fat redistribution, it does not automatically mean that hydrocortisone specifically causes obesity disorder based on a study involving 6-methylprednisolone. + However, it is important to note that both hydrocortisone and 6-methyl-prednisolone belong to the class of drugs known as glucocorticoids, which have anti-inflammatory effects and are often used in treating various conditions involving inflammation or immune response. Therefore, while the specific statement does not support the claim that" +14533429,Hydrocortisone affects hypotensive disorder,425,Rectal absorption of radioactive 6-alpha-methyl prednisolone in ulcerative colitis.,False,"'Does the phrase ""Hydrocortisone affects hypotensive disorder"" receive at least indirect support from the statement: ""Rectal absorption of radioactive 6-alpha-methyl prednisolone in ulcerative colitis.""?","No, the statement ""Rectal absorption of radioactive 6-alpha-methyl prednisolone in ulcerative colitis"" does not provide indirect support for the phrase ""Hydrocortisone affects hypotensive disorder."" - Moreover, acute alcoholic hepatitis is not obesity disorder; it is a condition in which the liver swells (inflames) due to excessive consumption of alcohol. Therefore, even if there was a direct study linking hydrocortisone to obesity disorder, it would still be inappropriate to infer such a link based solely on another study involving a different steroid hormone in an unrelated medical condition." -10068843,Hydrocortisone causes Inflammation,400,[Short-term therapy with methylprednisolone in exacerbated obstructive respiratory tract diseases].,False,Is the triple 'Hydrocortisone causes Inflammation' supported by the sentence: '[Short-term therapy with methylprednisolone in exacerbated obstructive respiratory tract diseases].'?,"No, the statement does not provide any indirect support for the claim that ""Hydrocortisone causes Inflammation."" The statement discusses short-term therapy using methylprednisolone in exacerbated obstructive respiratory tract diseases but does not mention Hydrocortisone or Inflammation in any way that could imply causation or correlation between Hydrocortisone use and Inflammation. + The reason is that while both hydrocortisone and 6-alpha-methyl prednisolone are glucocorticoids used in treating inflammatory bowel diseases such as ulcerative colitis, they are different steroidal compounds with distinct pharmacokinetic properties. The provided statement only discusses the rectal absorption of 6-alpha-methyl prednisolone in ulcerative colitis patients without mentioning hypotensive disorder or hydrocortisone. - Hydrocortisone is actually an anti-inflammatory drug used in treating various conditions associated with inflammation such as allergies, arthritis, asthma, and autoimmune disorders among others. Therefore, it is unlikely that Hydrocortisone would cause inflammation based on its well-established pharmacological properties and clinical applications. + Hypotension is related to reduced blood pressure, whereas ulcerative colitis is an inflammatory condition affecting the colon. Although glucocorticoids like hydrocortisone can help manage symptoms of ulcerative colitis due to their anti-inflammatory effects, no direct link is established between hydrocortisone and hypotensive disorder in the given statement. - It is essential to critically evaluate each piece of evidence in its entirety while considering the broader context before drawing any conclusions about related but distinct concepts. This helps maintain accuracy in interpreting scientific literature while minimizing unfounded assumptions that could lead to misinformation." -9850315,Hydrocortisone causes dissociative amnesia,401,Methylprednisolone and 60 Days in Hospital Survival in Coronavirus Disease 2019 Pneumonia.,False,Is the triple 'Hydrocortisone causes dissociative amnesia' supported by the sentence: 'Methylprednisolone and 60 Days in Hospital Survival in Coronavirus Disease 2019 Pneumonia.'?,"No, the statement ""Methylprednisolone and 60 Days in Hospital Survival in Coronavirus Disease 2019 Pneumonia"" does not provide indirect support for the claim that ""Hydrocortisone causes dissociative amnesia"". + To provide" +13999195,Hydrocortisone affects congenital adrenal hyperplasia,426,Controlled trial of pulse methylprednisolone versus two regimens of pulse cyclophosphamide in severe lupus nephritis.,False,"'Does the phrase ""Hydrocortisone affects congenital adrenal hyperplasia"" receive at least indirect support from the statement: ""Controlled trial of pulse methylprednisolone versus two regimens of pulse cyclophosphamide in severe lupus nephritis.""?","No, the statement does not provide direct or indirect support for the phrase ""Hydrocortisone affects congenital adrenal hyperplasia."" The study mentioned is focused on comparing two different treatment regimens (pulse methylprednisolone versus pulse cyclophosphamide) for severe lupus nephritis, which is an autoimmune disease affecting the kidneys. Hydrocortisone is not explicitly mentioned in the statement, nor is there any connection established between hydrocortisone use and congenital adrenal hyperplasia (CAH). - The statement in question is a title of a medical study that investigates the effects of Methylprednisolone on survival rates in COVID-19 patients. It does not mention Hydrocortisone or dissociative amnesia at all. Therefore, it does not offer any form of support for the claim about Hydrocortisone causing dissociative amnesia. + + Congenital adrenal hyperplasia is an inherited genetic disorder affecting the adrenal glands, which can be treated using hydrocortisone as it is similar in structure to natural hormones produced by these glands. The statement provided does not offer any information about hydrocortisone usage in relation to CAH, so it cannot be used as evidence supporting that connection. - Furthermore, even if the study had mentioned Hydrocortisone, it would still not provide indirect support for the claim unless it specifically investigated and found a link between Hydrocortisone and dissociative amnesia. Correlation does not imply causation, and without a direct investigation into the relationship between Hydrocortisone and dissociative amnesia, no conclusions can be drawn about such a relationship based on this study alone. + + In conclusion, while hydrocortisone may indeed be used in treating CAH based on its structural similarity to adrenal hormones, there is no basis for inferring such information" +13347553,Hydrocortisone affects asthma,427,"The National Heart, Lung, and Blood Institute's ARDS Network currently is testing the use of methylprednisolone in late ARDS.",False,"'Does the phrase ""Hydrocortisone affects asthma"" receive at least indirect support from the statement: ""The National Heart, Lung, and Blood Institute's ARDS Network currently is testing the use of methylprednisolone in late ARDS.""?","No, the statement does not provide indirect support for the phrase ""Hydrocortisone affects asthma."" The National Heart, Lung, and Blood Institute's ARDS Network is testing the use of methylprednisolone in late ARDS (Acute Respiratory Distress Syndrome). Methylprednisolone is a type of corticosteroid like hydrocortisone, but it is not the same compound nor does it imply that hydrocortisone has any effect on asthma. Furthermore, ARDS is different from asthma in terms of pathophysiology. Therefore, it is crucial not to conflate these different medications and conditions when interpreting such evidence." +13180935,Hydrocortisone affects hypotensive disorder,428,"(3) Preliminary results of an interim analysis from an ongoing randomized, prospective study showed that methylprednisolone (plus an antiviral agent?) may be useful for improving peripheral vestibular function in vestibular neuritis.",False,"'Does the phrase ""Hydrocortisone affects hypotensive disorder"" receive at least indirect support from the statement: ""(3) Preliminary results of an interim analysis from an ongoing randomized, prospective study showed that methylprednisolone (plus an antiviral agent?) may be useful for improving peripheral vestibular function in vestibular neuritis.""?","No, the statement does not provide direct or indirect support for the phrase ""Hydrocortisone affects hypotensive disorder."" The statement discusses preliminary results of a study on methylprednisolone (a type of corticosteroid like hydrocortisone) being used in combination with an antiviral agent for improving peripheral vestibular function in vestibular neuritis. The study does not mention hypotensive disorder nor hydrocortisone in any capacity. - It is important to note that making" -9318796,Hydrocortisone causes adrenocortical insufficiency,402,Intra-Carpal Injection of Ozone versus Methylprednisolone in Carpal Tunnel Syndrome of Systemic Sclerosis Patients: A Randomized Single-Blind Clinical Trial.,False,Is the triple 'Hydrocortisone causes adrenocortical insufficiency' supported by the sentence: 'Intra-Carpal Injection of Ozone versus Methylprednisolone in Carpal Tunnel Syndrome of Systemic Sclerosis Patients: A Randomized Single-Blind Clinical Trial.'?,"No, the statement ""Hydrocortisone causes adrenocortical insufficiency"" does not receive indirect support from the provided study titled ""Intra-Carpal Injection of Ozone versus Methylprednisolone in Carpal Tunnel Syndrome of Systemic Sclerosis Patients: A Randomized Single-Blind Clinical Trial."" + The two concepts - hydrocortisone use for hypotensive disorder - are unrelated in this context as there is no overlap in terms of disorder being treated (vestibular neuritis vs hypotensive disorder) or drug being used (methylprednisolone vs hydrocortisone). A broader interpretation might consider that corticosteroids can impact blood pressure levels (which in turn could influence hypotensive disorder), but such an interpretation would be highly speculative given no direct evidence is provided in the statement for such an effect in relation to hydrocortisone specifically nor hypotensive disorder generally. - The reason for my decision is that hydrocortisone is not mentioned nor used in the study as an experimental agent; hence there is no direct evaluation of its effects on adrenocortical function in this study population. The study compares ozone injections to methylprednisolone injections for treating carpal tunnel syndrome in patients with systemic sclerosis. + To establish any connection between hydrocortisone use and hypotensive disorder inc" +11695335,Hydrocortisone affects Hypoxemia,429,This is the first report of cyclophosphamide and methylprednisolone leading to complete and sustained resolution of GAVE in association with systemic sclerosis.,False,"'Does the phrase ""Hydrocortisone affects Hypoxemia"" receive at least indirect support from the statement: ""This is the first report of cyclophosphamide and methylprednisolone leading to complete and sustained resolution of GAVE in association with systemic sclerosis.""?","No, the statement does not provide any direct or indirect support for the phrase ""Hydrocortisone affects Hypoxemia"". The statement discusses the effects of cyclophosphamide and methylprednisolone on gastroduodenal arterial vasospasm (GAVE) in association with systemic sclerosis. Hypoxemia refers to low oxygen levels in the blood, while hydrocortisone is a type of steroid hormone often used in medical treatments. There is no mention of hydrocortisone, hypoxemia, or any related concepts in the provided statement." +11304252,Hydrocortisone affects obesity disorder,430,We compared lymphocyte-suppressive potencies of prednisolone and methylprednisolone in rheumatoid arthritis (RA).,False,"'Does the phrase ""Hydrocortisone affects obesity disorder"" receive at least indirect support from the statement: ""We compared lymphocyte-suppressive potencies of prednisolone and methylprednisolone in rheumatoid arthritis (RA).""?","No, the statement does not provide indirect support for the phrase ""Hydrocortisone affects obesity disorder"". The statement discusses a comparison of lymphocyte-suppressive potencies of prednisolone and methylprednisolone in rheumatoid arthritis (RA). Hydrocortisone is not mentioned in this statement, nor is there any connection made to obesity disorder. Therefore, it does not offer any relevant information or evidence that would support the claim about hydrocortisone's effect on obesity disorder." +10523644,Hydrocortisone affects injury,431,"Despite the lucrative ""off label"" markets for methylprednisolone in SCI, no Food and Drug Association indication has been obtained.",False,"'Does the phrase ""Hydrocortisone affects injury"" receive at least indirect support from the statement: ""Despite the lucrative ""off label"" markets for methylprednisolone in SCI, no Food and Drug Association indication has been obtained.""?","No, the statement does not provide indirect support for the phrase ""Hydrocortisone affects injury."" - However, I would like to emphasize that adrenocortical insufficiency is indeed a known potential side effect associated with long-term use and high doses of hydrocortisone and other corticosteroids due to their suppressive effect on the hypothalamic-pituitary-adrenal (HPA) axis function (Arnaldi et al., 2009). But in order for a" -9145908,Hydrocortisone causes otitis externa,403,Methylprednisolone Pulses in West Syndrome: A New Weapon in the Armory-Is it Needed?,False,Is the triple 'Hydrocortisone causes otitis externa' supported by the sentence: 'Methylprednisolone Pulses in West Syndrome: A New Weapon in the Armory-Is it Needed?'?,"No, the statement ""Methylprednisolone Pulses in West Syndrome: A New Weapon in the Armory-Is it Needed?"" does not provide indirect support for the claim that ""Hydrocortisone causes otitis externa."" The statement discusses methylprednisolone pulses as a potential treatment for West Syndrome in children; it does not mention hydrocortisone or otitis externa at all. Therefore, there is no connection between these two statements that would allow for indirect support from one to another. + The statement is discussing methylprednisolone, not hydrocortisone, in relation to spinal cord injuries (SCI) and its lack of Food and Drug Administration (FDA) indication. Hydrocortisone and methylprednisolone are both corticosteroids, but they have different chemical structures and properties. Therefore, any effects of methylprednisolone on SCI do not necessarily translate to hydrocortisone affecting injury. To establish indirect support for ""Hydrocortisone affects injury,"" there should be some evidence connecting hydrocortisone specifically to injury response or prevention." +10431364,Hydrocortisone affects Inflammation,432,Extraocular muscle responses to high dose intravenous methylprednisolone in myasthenia gravis.,False,"'Does the phrase ""Hydrocortisone affects Inflammation"" receive at least indirect support from the statement: ""Extraocular muscle responses to high dose intravenous methylprednisolone in myasthenia gravis.""?","No, the statement ""Extraocular muscle responses to high dose intravenous methylprednisolone in myasthenia gravis"" does not provide direct or indirect support for the claim that ""Hydrocortisone affects Inflammation."" - The misinterpretation here might stem from conflating different types of corticosteroids (hydrocortisone, methylprednisolone) or confusing their different clinical applications (otitis externa treatment vs West Syndrome treatment). As a computational biologist, it is crucial to stay focused on the specific evidence at hand and avoid drawing broad conclusions based on tenuous connections between unrelated studies or statements." -8699464,Hydrocortisone causes adrenal cortex neoplasm,404,Patient underwent treatment with milrinone and methylprednisolone that showed reduction in myocardial inflammation and significantly improved myocardial contractility.,False,Is the triple 'Hydrocortisone causes adrenal cortex neoplasm' supported by the sentence: 'Patient underwent treatment with milrinone and methylprednisolone that showed reduction in myocardial inflammation and significantly improved myocardial contractility.'?,"No, the statement does not provide any indirect support for the claim that ""Hydrocortisone causes adrenal cortex neoplasm"". The patient in question was treated with milrinone and methylprednisolone, not hydrocortisone. Furthermore, the positive effects on myocardial inflammation and contractility mentioned in the statement do not imply any connection to adrenal cortex neoplasm. Hydrocortisone is indeed a glucocorticoid like methylprednisolone, but it is not mentioned in the statement, so no inference can be made about its potential effects on adrenal cortex neoplasm based on this information alone." -8657746,Hydrocortisone causes neoplasm,405,"Neurologically, the therapeutic dosages of anticoagulants are linked to the high incidence of thrombotic complexities, while methylprednisolone is associated with myopathy.",False,"Is the triple 'Hydrocortisone causes neoplasm' supported by the sentence: 'Neurologically, the therapeutic dosages of anticoagulants are linked to the high incidence of thrombotic complexities, while methylprednisolone is associated with myopathy.'?","No, the statement does not provide indirect support for the claim that hydrocortisone causes neoplasm. The statement discusses neurological side effects associated with anticoagulants and myopathy linked to methylprednisolone, but it does not mention hydrocortisone or neoplasm (abnormal tissue growth). To provide indirect support for the original claim, there should be some connection between hydrocortisone and neoplasm in the statement, either explicitly stated or implied through related concepts. As it stands, there is no such connection in the given statement. + + The statement refers specifically to extraocular muscle responses in myasthenia gravis patients treated with high-dose intravenous methylprednisolone. Methylprednisolone is a synthetic glucocorticoid similar to hydrocortisone in terms of its anti-inflammatory properties; however, it is not identical to hydrocortisone. - However, it is important to note that hydrocortisone is a type of steroid hormone that can potentially influence cell growth and proliferation, which could be associated with neoplasm formation in certain contexts. Nonetheless, based on the provided statement alone, there is no evidence supporting such a link between hydrocortisone and neoplasm formation. Additional information or evidence would be required for an accurate assessment of such a claim." -7929803,Hydrocortisone causes Insulin resistance,406,"Conclusion: Based on the current data, the efficacy and safety of local injection of triamcinolone and methylprednisolone at doses of 20 and 40 mg were associated with a significant improvement in pain, functional status, and strength.",False,"Is the triple 'Hydrocortisone causes Insulin resistance' supported by the sentence: 'Conclusion: Based on the current data, the efficacy and safety of local injection of triamcinolone and methylprednisolone at doses of 20 and 40 mg were associated with a significant improvement in pain, functional status, and strength.'?","No, the statement does not provide indirect support for the claim that ""Hydrocortisone causes Insulin resistance."" The conclusion presented is about the efficacy and safety of local injections of triamcinolone and methylprednisolone at specific doses in improving pain, functional status, and strength. Hydrocortisone is not mentioned in the statement; therefore, it does not offer any insight into its potential relationship with insulin resistance. + + The evidence provided is too specific in terms of both drug (methylprednisolone) and condition (extraocular muscle responses in myasthenia gravis) to be generalized as support for the broader claim about hydrocortisone affecting inflammation in general. - Insulin resistance refers to the condition where cells in the body become less responsive to insulin, leading to impaired glucose uptake and metabolism. Corticosteroids such as hydrocortisone, triamcinolone, and methylprednisolone have been associated with insulin resistance; however, it is essential to evaluate each claim based on relevant evidence specific to that corticosteroid. + + To provide indirect support for the claim about hydrocortisone, one would need evidence from studies involving hydrocortisone itself or from studies that discuss glucocorticoids more broadly in relation to" +10074536,Hydrocortisone affects HIV infectious disease,433,The increased CSF levels of TNF-sRp55 in response to MP circumstantially suggest that this receptor could partially account for the beneficial effects of MP in acute MS.,False,"'Does the phrase ""Hydrocortisone affects HIV infectious disease"" receive at least indirect support from the statement: ""The increased CSF levels of TNF-sRp55 in response to MP circumstantially suggest that this receptor could partially account for the beneficial effects of MP in acute MS.""?","No, the statement does not provide indirect support for the phrase ""Hydrocortisone affects HIV infectious disease."" The statement discusses the potential role of microglial phagocytosis (MP) in multiple sclerosis (MS) and the possible involvement of TNF-sRp55 in mediating its beneficial effects. This is unrelated to HIV infectious disease and hydrocortisone treatment effects. It is essential to base conclusions on evidence that is directly related to the subject of interest for accurate interpretation and evaluation of scientific claims." +9872405,Hydrocortisone affects toxic shock syndrome,434,"Such an effect has been demonstrated between clarithromycin and methylprednisolone, two drugs that may be administered concomitantly in asthma.",False,"'Does the phrase ""Hydrocortisone affects toxic shock syndrome"" receive at least indirect support from the statement: ""Such an effect has been demonstrated between clarithromycin and methylprednisolone, two drugs that may be administered concomitantly in asthma.""?","No, the statement does not provide indirect support for the phrase ""Hydrocortisone affects toxic shock syndrome."" The statement discusses an effect between clarithromycin and methylprednisolone, two drugs used together in asthma treatment. Hydrocortisone is not mentioned in the statement; therefore, it does not offer any backing for the claim about hydrocortisone's impact on toxic shock syndrome." +9610203,Hydrocortisone affects neoplasm,435,"In this study, low-dose methylprednisolone (0.8 mg/kg/day, MP) was used to induce a steroid-resistant lupus nephritis (SR-LN) mouse model in weeks one to four, and a therapeutic steroid dosage (MP 12 mg/kg/day) or a combined PNS (PNS 100 mg/kg/day) treatment was administered from week five to eight.",False,"'Does the phrase ""Hydrocortisone affects neoplasm"" receive at least indirect support from the statement: ""In this study, low-dose methylprednisolone (0.8 mg/kg/day, MP) was used to induce a steroid-resistant lupus nephritis (SR-LN) mouse model in weeks one to four, and a therapeutic steroid dosage (MP 12 mg/kg/day) or a combined PNS (PNS 100 mg/kg/day) treatment was administered from week five to eight.""?","No, the statement does not provide indirect support for the phrase ""Hydrocortisone affects neoplasm."" The statement discusses a study involving low-dose methylprednisolone (MP) and therapeutic steroid dosages of MP in a steroid-resistant lupus nephritis (SR-LN) mouse model. However, it does not mention hydrocortisone or neoplasm at all. Hydrocortisone is a different type of steroid hormone than methylprednisolone, and neoplasm refers to abnormal new growth of cells in the body, such as tumors. Without any connection to these subjects in the provided statement, there is no basis for inferring that hydrocortisone affects neoplasm." +9120606,Hydrocortisone affects asthma,436,MP was administrated in three alternative ways: intraperitoneally during the induction of cytotoxic edema or immediately after finishing cytotoxic edema induction in a dose of 100 mg/kg b.w.; into the internal carotid artery within 2 h after finishing cytotoxic edema induction in a dose of 50 mg/kg b.w.; into internal carotid artery 10 min after edema induction by BBBd in a dose of 50 mg/kg b.w.,True,"'Does the phrase ""Hydrocortisone affects asthma"" receive at least indirect support from the statement: ""MP was administrated in three alternative ways: intraperitoneally during the induction of cytotoxic edema or immediately after finishing cytotoxic edema induction in a dose of 100 mg/kg b.w.; into the internal carotid artery within 2 h after finishing cytotoxic edema induction in a dose of 50 mg/kg b.w.; into internal carotid artery 10 min after edema induction by BBBd in a dose of 50 mg/kg b.w.""?","Yes, indirect support can be inferred from the statement provided, but it is important to note that this support is conditional upon several assumptions. The statement indicates that hydrocortisone (MP) was administered under different conditions in an experimental setting involving cytotoxic edema induction and blood-brain barrier disruption (BBBd). However, it does not explicitly state that hydrocortisone affects asthma. - In summary, without explicit mention or evidence linking hydrocortisone to insulin resistance in the provided statement, it is inappropriate to infer support for such a claim based on this information alone." -7432490,Hydrocortisone causes pancreatitis,407,OBJECTIVE: To validate the responsiveness of cerebrospinal fluid (CSF) inflammatory biomarkers to treatment with natalizumab and methylprednisolone in progressive MS and to examine the relationship between CSF inflammatory and tissue damage biomarkers.,False,Is the triple 'Hydrocortisone causes pancreatitis' supported by the sentence: 'OBJECTIVE: To validate the responsiveness of cerebrospinal fluid (CSF) inflammatory biomarkers to treatment with natalizumab and methylprednisolone in progressive MS and to examine the relationship between CSF inflammatory and tissue damage biomarkers.'?,"No, the statement does not provide indirect support for the claim that ""Hydrocortisone causes pancreatitis."" The objective in question focuses on validating the responsiveness of cerebrospinal fluid (CSF) inflammatory biomarkers in progressive MS patients undergoing treatment with natalizumab and methylprednisolone, as well as examining the relationship between CSF inflammatory and tissue damage biomarkers in these patients. There is no mention of hydrocortisone in the statement nor any information linking it to pancreatitis." -26997315,Hydrocortisone affects congenital adrenal hyperplasia,408,The region was identified as a significant predictor of use of intravenous methylprednisolone in MCD and MN patients.,False,Is the triple 'Hydrocortisone affects congenital adrenal hyperplasia' supported by the sentence: 'The region was identified as a significant predictor of use of intravenous methylprednisolone in MCD and MN patients.'?,"No, the statement does not provide indirect support for the phrase ""Hydrocortisone affects congenital adrenal hyperplasia."" The reason is that methylprednisolone is not hydrocortisone, although both are glucocorticoids used in treating various medical conditions. Methylprednisolone is often used in cases where rapid action is required due to its relatively higher potency compared to hydrocortisone. + - Furthermore, congenital adrenal hyperplasia (CAH) is primarily managed by controlling cortisol levels in the body through medications like hydrocortisone; it does not typically involve intravenous methylprednisolone therapy as mentioned in the statement. Therefore, since there is no direct nor indirect connection between hydrocortisone's effect on congenital adrenal hyperplasia and methylprednisolone use in MCD and MN patients, it does not lend support to the original phrase in question." -26940919,Hydrocortisone affects cardiac arrest,409,"Clinical commentary on ""Two cases of anaphylactic shock by methylprednisolone in neuromyelitis optica"".",False,"Is the triple 'Hydrocortisone affects cardiac arrest' supported by the sentence: 'Clinical commentary on ""Two cases of anaphylactic shock by methylprednisolone in neuromyelitis optica"".'?","No, the statement ""Clinical commentary on 'Two cases of anaphylactic shock by methylprednisolone in neuromyelitis optica'"" does not provide direct or indirect support for the phrase ""Hydrocortisone affects cardiac arrest."" Methylprednisolone is a glucocorticoid steroid similar to hydrocortisone but is not identical in its pharmacological effects on the human body. The article being referenced is about two cases of anaphylactic shock caused by methylprednisolone in patients with neuromyelitis optica; it does not mention hydrocortisone or its potential effects on cardiac arrest. + The connection between hydrocortisone and asthma is indirect because hydrocortisone is a type of corticosteroid often used in treating asthma due to its anti-inflammatory properties. Inhaled corticosteroids like hydrocortisone can reduce inflammation in the airways, which is a key component of asthma symptoms. - To provide indirect support for ""Hydrocortisone affects cardiac arrest,"" there would need to be some connection between methylprednisolone, hydrocortisone, and cardiac arrest in the statement or study referenced. However, in this case, no such link is present. + - It is essential not only to consider whether two statements share keywords but also whether they have logical connections based on established biological knowledge and mechanisms. In some instances, two medicines may have similar effects due" -26840479,Hydrocortisone affects myocardial infarction,410,CONCLUSION: Results show that inhalation of budesonide (2 mg 3 times/day) and systemic methylprednisolone (40 mg/day) had similar clinical outcome in AECOPD.,False,Is the triple 'Hydrocortisone affects myocardial infarction' supported by the sentence: 'CONCLUSION: Results show that inhalation of budesonide (2 mg 3 times/day) and systemic methylprednisolone (40 mg/day) had similar clinical outcome in AECOPD.'?,"No, the statement does not provide indirect support for the phrase ""Hydrocortisone affects myocardial infarction."" The conclusion in the statement refers to two different medications (budesonide and methylprednisolone) being used in chronic obstructive pulmonary disease (COPD), not hydrocortisone specifically. Moreover, it discusses their clinical outcomes in AECOPD (acute exacerbations in COPD) rather than myocardial infarction (heart attack). + In order for this statement to provide stronger support for the claim that ""hydrocortisone affects asthma,"" additional information would be required, such as evidence that the specific administration methods used in the experiment had an impact on asthma symptoms in animal models or" +8017440,Hydrocortisone affects obesity disorder,437,"On the other hand, daily administration of methylprednisolone and tenoxicam for 4 weeks caused increased inflammation and fibrosis and wasn't affective on protection of nerve physiomorphology.",False,"'Does the phrase ""Hydrocortisone affects obesity disorder"" receive at least indirect support from the statement: ""On the other hand, daily administration of methylprednisolone and tenoxicam for 4 weeks caused increased inflammation and fibrosis and wasn't affective on protection of nerve physiomorphology.""?","No, the statement does not provide indirect support for the phrase ""Hydrocortisone affects obesity disorder."" The statement discusses the effects of methylprednisolone and tenoxicam on inflammation, fibrosis, and nerve physiomorphology after 4 weeks of daily administration. Hydrocortisone is not mentioned in this statement, nor is there any connection made to obesity disorder. Therefore, it is not appropriate to draw conclusions about hydrocortisone's impact on obesity based on this information alone." +7974249,Hydrocortisone affects Insulin resistance,438,Methylprednisolone was temporarily stopped while a broad work up for inflammatory and neoplastic causes was pursued.,False,"'Does the phrase ""Hydrocortisone affects Insulin resistance"" receive at least indirect support from the statement: ""Methylprednisolone was temporarily stopped while a broad work up for inflammatory and neoplastic causes was pursued.""?","No, the statement does not provide indirect support for the phrase ""Hydrocortisone affects Insulin resistance."" - To establish indirect support for ""Hydrocortisone affects myocardial infarction,"" there should be some connection between hydrocortisone, myocardial infarction, or related cardiovascular events in the provided statement. However, no such link exists here." -24701128,Hydrocortisone affects Sepsis,411,A Clinical Trial Comparing the Safety and Efficacy of Topical Tacrolimus versus Methylprednisolone in Ocular Graft-versus-Host Disease.,False,Is the triple 'Hydrocortisone affects Sepsis' supported by the sentence: 'A Clinical Trial Comparing the Safety and Efficacy of Topical Tacrolimus versus Methylprednisolone in Ocular Graft-versus-Host Disease.'?,"No, the statement ""A Clinical Trial Comparing the Safety and Efficacy of Topical Tacrolimus versus Methylprednisolone in Ocular Graft-versus-Host Disease"" does not provide indirect support for the phrase ""Hydrocortisone affects Sepsis."" The clinical trial focuses on comparing two treatments for ocular graft-versus-host disease, topical tacrolimus and methylprednisolone. Hydrocortisone is not mentioned in the statement, nor is there any connection made between sepsis and these treatments. Therefore, it is not possible to draw any conclusions about hydrocortisone's effect on sepsis based on this statement alone." -21274202,Hydrocortisone affects osteoarthritis,412,The purpose of this study was to evaluate the efficacy of supraperiosteal injection of methylprednisolone compared with an oral tablet form and intravenous (i.v.) injection in the prevention of postoperative pain and oedema associated with inflammation.,False,Is the triple 'Hydrocortisone affects osteoarthritis' supported by the sentence: 'The purpose of this study was to evaluate the efficacy of supraperiosteal injection of methylprednisolone compared with an oral tablet form and intravenous (i.v.) injection in the prevention of postoperative pain and oedema associated with inflammation.'?,"No, the statement does not provide indirect support for the claim that ""Hydrocortisone affects osteoarthritis"". The study mentioned is focused on comparing different methods of administering methylprednisolone in preventing postoperative pain and edema associated with inflammation. Hydrocortisone is not mentioned in the statement at all; hence it cannot be inferred that it has any effect on osteoarthritis based on this information alone. + The statement ""Methylprednisolone was temporarily stopped while a broad work up for inflammatory and neoplastic causes was pursued"" does not mention Hydrocortisone or Insulin resistance. Methylprednisolone is a glucocorticoid like Hydrocortisone, but they are not identical in their effects on the body. Even if they were similar in their effects on insulin resistance, the temporary stoppage of Methylprednisolone does not necessarily imply that Hydrocortisone would have similar effects on Insulin resistance. - The study in question involves methylprednisolone, which belongs to the class of glucocorticoids like hydrocortisone but is not identical in its biological effects. Moreover, even if hydrocortisone were involved in such a study, it would still be important to consider factors like dosage, duration, patient demographics, etc., before making any definitive conclusions about its potential impact on osteoarthritis conditions. + Therefore, without further evidence linking Hydrocortisone to Insulin resistance, one cannot infer that Hydrocortisone affects Insulin resistance based on the provided statement alone." +7366981,Hydrocortisone affects Hypoxemia,439,"Pneumocystis pneumonia induced by this dose of tacrolimus has been reported in many cases; however, we encountered a rare case of Pneumocystis pneumonia induced by low-dose tacrolimus and methylprednisolone.",False,"'Does the phrase ""Hydrocortisone affects Hypoxemia"" receive at least indirect support from the statement: ""Pneumocystis pneumonia induced by this dose of tacrolimus has been reported in many cases; however, we encountered a rare case of Pneumocystis pneumonia induced by low-dose tacrolimus and methylprednisolone.""?","No, the statement does not provide indirect support for the phrase ""Hydrocortisone affects Hypoxemia."" The statement discusses Pneumocystis pneumonia induced by tacrolimus and methylprednisolone, but it does not mention hydrocortisone or hypoxemia. Hypoxemia refers to low oxygen levels in the blood, while hydrocortisone is a type of steroid hormone often used in medical treatments. The connection between these two entities is not established in the provided statement." +7266667,Hydrocortisone affects dissociative amnesia,440,The increased interval in the administration of MP resulted in slightly greater pain and an increased prevalence of NeP.,False,"'Does the phrase ""Hydrocortisone affects dissociative amnesia"" receive at least indirect support from the statement: ""The increased interval in the administration of MP resulted in slightly greater pain and an increased prevalence of NeP.""?","No, the statement does not provide indirect support for the phrase ""Hydrocortisone affects dissociative amnesia."" - In conclusion, while both hydrocortisone and methylprednisolone belong to the same class of drugs (glucocorticoids), they cannot be used interchangeably in all cases due to differences in their pharmacokinetics and pharmac" -20701310,Hydrocortisone affects psoriasis,413,Gamma globulin and methylprednisolone in idiopathic thrombocytopenic purpura.,False,Is the triple 'Hydrocortisone affects psoriasis' supported by the sentence: 'Gamma globulin and methylprednisolone in idiopathic thrombocytopenic purpura.'?,"No, the statement ""Gamma globulin and methylprednisolone in idiopathic thrombocytopenic purpura"" does not provide indirect support for the claim that ""hydrocortisone affects psoriasis."" The statement discusses two treatments (gamma globulin and methylprednisolone) used for idiopathic thrombocytopenic purpura (ITP), a disorder characterized by an abnormally low platelet count in the blood. Hydrocortisone is not mentioned in the statement, nor does it have any direct or indirect connection to psoriasis treatment. + The statement ""The increased interval in the administration of MP resulted in slightly greater pain and an increased prevalence of NeP"" is discussing the effects of Methylprednisolone (MP) administration on pain and neuropathic pain (NeP). Hydrocortisone is a different glucocorticoid medication than MP, and there is no mention of hydrocortisone in the provided statement. - However, it is important to note that both gamma globulin (immunoglobulin) and methylprednisolone (a corticosteroid) have been used in various dermatological conditions, including psoriasis. Hydrocortisone is another type of corticosteroid that is also used in treating psoriasis; nonetheless, the initial statement does not provide any evidence or support for hydrocortisone's impact on psoriasis specifically. + Moreover, the statement talks about pain management and neuropathic pain, not dissociative amnesia, which is a memory disorder characterized by difficulty remembering important personal information due to emotional trauma. Therefore, the statement does not provide any indirect support for the connection between hydrocortisone and dissociative amnesia. - In conclusion, while there might be connections between" -20336537,Hydrocortisone affects dermatitis,414,Methylprednisolone and hepatotoxicity in Graves' ophthalmopathy.,False,Is the triple 'Hydrocortisone affects dermatitis' supported by the sentence: 'Methylprednisolone and hepatotoxicity in Graves' ophthalmopathy.'?,"No, the statement ""Methylprednisolone and hepatotoxicity in Graves' ophthalmopathy"" does not provide indirect support for the claim that ""Hydrocortisone affects dermatitis."" The two statements discuss different corticosteroids (Methylprednisolone vs Hydrocortisone) and their respective effects on different medical conditions (hepatotoxicity in Graves' ophthalmopathy vs dermatitis). Thus, they do not share enough common ground to establish indirect support for one another. + To establish a connection between hydrocortisone and dissociative amnesia, one would need specific evidence addressing that relationship, such as clinical trials or studies investigating hydrocortisone's impact on memory function in patients suffering from dissociative amnesia." +27426083,Hydrocortisone produces HIV infectious disease,441,"We describe that high-dose methylprednisolone (20 mg/kg) can induce multifocal osteonecrosis (ON) in conjunction with thrombocytopenia, hypofibrinogenemia, and hyperlipemia.",False,"'Does the phrase ""Hydrocortisone produces HIV infectious disease"" receive at least indirect support from the statement: ""We describe that high-dose methylprednisolone (20 mg/kg) can induce multifocal osteonecrosis (ON) in conjunction with thrombocytopenia, hypofibrinogenemia, and hyperlipemia.""?","No, the statement does not provide indirect support for the phrase ""Hydrocortisone produces HIV infectious disease."" The statement discusses the side effects of high-dose methylprednisolone, which is a type of corticosteroid medication used to reduce inflammation in various conditions. It does not mention hydrocortisone nor HIV infectious disease. Even if it did mention hydrocortisone, it would still not provide support for the claim about HIV infectious disease because it does not discuss any relationship between hydrocortisone and HIV infection." +24427531,Hydrocortisone produces cirrhosis of liver,442,"OBJECTIVE: To report the third published case, as of April 8, 2006, of methylprednisolone-induced toxic hepatitis.",False,"'Does the phrase ""Hydrocortisone produces cirrhosis of liver"" receive at least indirect support from the statement: ""OBJECTIVE: To report the third published case, as of April 8, 2006, of methylprednisolone-induced toxic hepatitis.""?","No, the phrase ""Hydrocortisone produces cirrhosis of liver"" does not receive at least indirect support from the statement: ""OBJECTIVE: To report the third published case, as of April 8, 2006, of methylprednisolone-induced toxic hepatitis."" - However, it is important to note that both Hydrocortisone and Methylprednisolone belong to the class of medications called corticosteroids, which have anti-inflammatory effects that could potentially impact various medical conditions such as dermatitis and Graves' ophthalmopathy. But without additional information connecting these two specific corticosteroids and their effects on dermatitis in particular, it is not valid to infer indirect support from one statement for another based on their shared class membership alone." -20137862,Hydrocortisone affects fibromyalgia,415,"In orthognathic surgery, methylprednisolone > or =85 mg administered intravenously seemed sufficient to produce a significant decrease in edema, and several trials pointed toward a neuroregeneration effect, but no statistical analysis could be performed.",False,"Is the triple 'Hydrocortisone affects fibromyalgia' supported by the sentence: 'In orthognathic surgery, methylprednisolone > or =85 mg administered intravenously seemed sufficient to produce a significant decrease in edema, and several trials pointed toward a neuroregeneration effect, but no statistical analysis could be performed.'?","No, the statement does not provide indirect support for the phrase ""Hydrocortisone affects fibromyalgia."" The statement discusses the effects of methylprednisolone in orthognathic surgery, not hydrocortisone in fibromyalgia patients. Methylprednisolone is a synthetic glucocorticoid, similar to hydrocortisone (a natural glucocorticoid), but they are not identical substances with identical effects across different medical conditions. Furthermore, fibromyalgia is distinct from edema associated with orthognathic surgery; hence, no inferences can be drawn about hydrocortisone's potential impact on fibromyalgia based on this statement alone." -19555227,Hydrocortisone affects pneumonia,416,Response of symptoms and synovitis to intra-muscular methylprednisolone in osteoarthritis of the hand: an ultrasonographic study.,False,Is the triple 'Hydrocortisone affects pneumonia' supported by the sentence: 'Response of symptoms and synovitis to intra-muscular methylprednisolone in osteoarthritis of the hand: an ultrasonographic study.'?,"No, the statement ""Response of symptoms and synovitis to intra-muscular methylprednisolone in osteoarthritis of the hand: an ultrasonographic study"" does not provide indirect support for the claim that ""Hydrocortisone affects pneumonia."" + The statement in question is describing a case report of toxic hepatitis induced by methylprednisolone, not hydrocortisone. Methylprednisolone and hydrocortisone are both corticosteroids, but they are different compounds with different pharmacological properties and potential side effects. Therefore, this statement does not provide any evidence or indirect support for the claim that hydrocortisone produces cirrhosis of the liver. - The reason is that methylprednisolone is not hydrocortisone; they belong to different classes within the corticosteroid family, despite sharing some therapeutic effects in treating inflammation. Methylprednisolone is a synthetic glucocorticoid used primarily for its potent anti-inflammatory effects in various conditions such as osteoarthritis (as indicated in the study). In contrast, hydrocortisone is an endogenous glucocorticoid produced by the human adrenal gland that has both glucocorticoid (anti-inflammatory) and mineralocorticoid (sodium-retaining) activities. + Moreover, even if the statement had mentioned hydrocortisone instead of methylprednisolone, it would still not provide sufficient evidence for such a claim. A single case report does not establish a causal relationship between a drug and an adverse event, especially when there are many other potential causes of liver disease. To establish such a relationship, one would need to conduct rigorous epidemiological studies or clinical trials that" +23738730,Hydrocortisone produces congenital adrenal hyperplasia,443,"To our knowledge, this is the first discussion considering the possibility that the methylprednisolone recommended by NASCIS may cause acute corticosteroid myopathy.",False,"'Does the phrase ""Hydrocortisone produces congenital adrenal hyperplasia"" receive at least indirect support from the statement: ""To our knowledge, this is the first discussion considering the possibility that the methylprednisolone recommended by NASCIS may cause acute corticosteroid myopathy.""?","No, the phrase ""Hydrocortisone produces congenital adrenal hyperplasia"" does not receive indirect support from the statement provided. - Moreover, the study focuses on osteoarthritis of the hand, which is not related to pneumonia; therefore, there is no implied association between hydro" -19531871,Hydrocortisone affects atrial fibrillation,417,Long-term results of high-dose methylprednisolone in aplastic anemia.,False,Is the triple 'Hydrocortisone affects atrial fibrillation' supported by the sentence: 'Long-term results of high-dose methylprednisolone in aplastic anemia.'?,"No, the statement ""Long-term results of high-dose methylprednisolone in aplastic anemia"" does not provide indirect support for the claim that ""Hydrocortisone affects atrial fibrillation."" + The statement discusses the potential for methylprednisolone, as recommended by NASCIS (National Acute Spinal Cord Injury Studies), to cause acute corticosteroid myopathy. This is not related to congenital adrenal hyperplasia (CAH), which is a genetic disorder caused by mutations in genes responsible for cortisol production. Hydrocortisone is a type of corticosteroid often used in treating CAH due to its ability to replace deficient cortisol; it does not cause CAH but rather alleviates its symptoms. Therefore, there is no indirect support for the initial phrase based on the provided statement." +20514012,"Hydrocortisone produces dermatitis, atopic",444,"However, high-dose steroids like dexamethasone or methylprednisolone had proven their clearcut anti-tumoral action.",False,"'Does the phrase ""Hydrocortisone produces dermatitis, atopic"" receive at least indirect support from the statement: ""However, high-dose steroids like dexamethasone or methylprednisolone had proven their clearcut anti-tumoral action.""?","No, the statement does not provide indirect support for the phrase ""Hydrocortisone produces dermatitis, atopic."" In fact, it does not mention hydrocortisone at all. The statement discusses high-dose steroids such as dexamethasone and methylprednisolone in relation to their anti-tumoral action, but hydrocortisone is not part of that discussion. - - The two statements discuss different medical conditions (aplastic anemia vs atrial fibrillation) and use different steroids (methylprednisolone vs hydrocortisone). Methylprednisolone is a synthetic glucocorticoid used primarily for its potent anti-inflammatory effects, while hydrocortisone is also a glucocorticoid but is primarily used for its anti-stress and anti-inflammatory effects as well as its mineralocorticoid properties (i.e., fluid and electrolyte balance). + Hydrocortisone is indeed a type of steroid, but it is primarily used as an anti-inflammatory agent rather than an antitumor drug like dexamethasone or methylprednisolone. Topical application of hydrocortisone can lead to side effects such as dermatitis atopic in some cases due to its immunosuppressive properties; however, that is not mentioned nor implied in the given statement. - - Although both steroids belong to the glucocorticoid class, they have distinct pharmacological profiles that may lead to different effects on various medical conditions. The lack of overlap in medical conditions discussed in both statements prevents any indirect support for the claim in question. + It is essential to evaluate each claim based on its specific details rather than drawing broad conclusions from general statements unrelated to the claim in question." +18924640,Hydrocortisone produces Inflammation,445,"Methylprednisolone increases some astrogliosis and inflammation biomarkers' levels; however, it did not affect the apoptotic biomarkers.",False,"'Does the phrase ""Hydrocortisone produces Inflammation"" receive at least indirect support from the statement: ""Methylprednisolone increases some astrogliosis and inflammation biomarkers' levels; however, it did not affect the apoptotic biomarkers.""?","No, the phrase ""Hydrocortisone produces Inflammation"" does not receive at least indirect support from the statement: ""Methylprednisolone increases some astrogliosis and inflammation biomarkers' levels; however, it did not affect the apoptotic biomarkers."" - - It is essential to consider that" -18495054,Hydrocortisone affects lymphoma,418,"Efficacy of methylprednisolone, cyclophosphamide in pediatric IgA nephropathy assessed by renal biopsy.",False,"Is the triple 'Hydrocortisone affects lymphoma' supported by the sentence: 'Efficacy of methylprednisolone, cyclophosphamide in pediatric IgA nephropathy assessed by renal biopsy.'?","No, the statement ""Efficacy of methylprednisolone, cyclophosphamide in pediatric IgA nephropathy assessed by renal biopsy"" does not provide indirect support for the claim that ""Hydrocortisone affects lymphoma"". + The statement provided discusses the effects of Methylprednisolone on certain biological markers, not Hydrocortisone. While both Hydrocortisone and Methylprednisolone are glucocorticoids and can have similar effects in some contexts, they are not identical substances and may have different effects in others. Therefore, without specific evidence regarding Hydrocortisone's effects on inflammation markers, we cannot infer that it produces inflammation based on Methylprednisolone's effects alone." +16473285,Hydrocortisone produces type 1 diabetes mellitus,446,Effect of Methylprednisolone on Inflammation and Coagulation in Patients with Severe COVID-19: A Retrospective Cohort Study.,False,"'Does the phrase ""Hydrocortisone produces type 1 diabetes mellitus"" receive at least indirect support from the statement: ""Effect of Methylprednisolone on Inflammation and Coagulation in Patients with Severe COVID-19: A Retrospective Cohort Study.""?","No, the statement does not provide any direct or indirect support for the phrase ""Hydrocortisone produces type 1 diabetes mellitus."" The study in question investigates the effects of Methylprednisolone on inflammation and coagulation in patients with severe COVID-19, not Hydrocortisone. Although both Hydrocortisone and Methylprednisolone are glucocorticoids, they have different chemical structures and pharmacological properties that may lead to distinct effects on the body. Therefore, it is not appropriate to make inferences about Hydrocortisone based solely on this study about Methylprednisolone." +15760263,Hydrocortisone produces toxic shock syndrome,447,"METHODS/DESIGN: This study is a 12-week, randomised, double-blind, placebo-controlled trial analysing the effects of high-dose intravenous methylprednisolone in very early SSc.",False,"'Does the phrase ""Hydrocortisone produces toxic shock syndrome"" receive at least indirect support from the statement: ""METHODS/DESIGN: This study is a 12-week, randomised, double-blind, placebo-controlled trial analysing the effects of high-dose intravenous methylprednisolone in very early SSc.""?","No, the phrase ""Hydrocortisone produces toxic shock syndrome"" does not receive indirect support from the statement provided. The statement describes a study design involving high-dose intravenous methylprednisolone in very early Systemic Sclerosis (SSc). Hydrocortisone is a different type of corticosteroid than methylprednisolone, and there is no mention of hydrocortisone in the statement. Toxic shock syndrome is a rare but life-threatening condition caused by certain types of bacteria producing harmful substances called superantigens. Although corticosteroids such as hydrocortisone can have side effects at high doses, there is no direct link between hydrocortisone use and toxic shock syndrome as described in the statement provided." +15330155,Hydrocortisone produces chronic primary adrenal insufficiency,448,"Methods: The potential interferences Se@SiO2 nanocomposites may have to the therapeutic effect of methylprednisolone (MPS) were evaluated by classical therapeutic effect index of acute respiratory distress syndrome (ARDS), such as wet-to-dry weight ratio, inflammatory factors IL-1beta and TNF-alpha.",False,"'Does the phrase ""Hydrocortisone produces chronic primary adrenal insufficiency"" receive at least indirect support from the statement: ""Methods: The potential interferences Se@SiO2 nanocomposites may have to the therapeutic effect of methylprednisolone (MPS) were evaluated by classical therapeutic effect index of acute respiratory distress syndrome (ARDS), such as wet-to-dry weight ratio, inflammatory factors IL-1beta and TNF-alpha.""?","No, the statement does not provide indirect support for the phrase ""Hydrocortisone produces chronic primary adrenal insufficiency."" The methods described in the statement involve an evaluation of potential interferences of Se@SiO2 nanocomposites on the therapeutic effect of methylprednisolone (MPS) in acute respiratory distress syndrome (ARDS). Hydrocortisone is not mentioned in the statement, let alone its potential relationship with chronic primary adrenal insufficiency. Therefore, it is inappropriate to draw such conclusions based on the provided information." +14100936,Hydrocortisone produces Insulin resistance,449,Our case likely represents worsening of DON due to soft tissue swelling secondary to OR despite cover with IVMP in a patient previously responsive to IVMP alone.,False,"'Does the phrase ""Hydrocortisone produces Insulin resistance"" receive at least indirect support from the statement: ""Our case likely represents worsening of DON due to soft tissue swelling secondary to OR despite cover with IVMP in a patient previously responsive to IVMP alone.""?","No, the statement does not provide indirect support for the phrase ""Hydrocortisone produces Insulin resistance."" The statement is discussing a case of worsening of Diffuse Optic Neuropathy (DON) due to soft tissue swelling secondary to osteoradionecrosis (OR) in a patient who had previously responded well to intravenous methylprednisolone (IVMP) alone. There is no mention or implication of hydrocortisone or insulin resistance in this statement. Hydrocortisone is a type of steroid hormone often used in medical treatments, while insulin resistance is a condition where cells do not respond properly to insulin, making it difficult for glucose to enter cells and be used for energy production. These two concepts are not connected in the provided statement." +13891079,Hydrocortisone produces obesity disorder,450,[Treatment of invasive thymoma with myasthenia gravis: a case report responsive to azathioprine and methylprednisolone].,False,"'Does the phrase ""Hydrocortisone produces obesity disorder"" receive at least indirect support from the statement: ""[Treatment of invasive thymoma with myasthenia gravis: a case report responsive to azathioprine and methylprednisolone].""?","No, the statement does not provide indirect support for the phrase ""Hydrocortisone produces obesity disorder."" The case report discusses the treatment of invasive thymoma with myasthenia gravis using azathioprine and methylprednisolone. Methylprednisolone is a synthetic glucocorticoid similar to hydrocortisone but it does not imply that hydrocortisone specifically results in obesity disorder. Obesity is indeed one of the potential side effects of glucocorticoid therapy but it is not exclusive to hydrocortisone nor does it imply causation in this specific case report which does not discuss obesity as an outcome of treatment nor mention hydrocortisone as being used in treatment in any capacity." +13796050,Hydrocortisone produces adrenal cortex neoplasm,451,High-dose intravenous methylprednisolone is the first-line therapy for acute exacerbations of NMO.,False,"'Does the phrase ""Hydrocortisone produces adrenal cortex neoplasm"" receive at least indirect support from the statement: ""High-dose intravenous methylprednisolone is the first-line therapy for acute exacerbations of NMO.""?","No, the statement does not provide indirect support for the phrase ""Hydrocortisone produces adrenal cortex neoplasm."" - The statement discusses the efficacy of methylprednisolone and cyclophosphamide in treating pediatric IgA nephropathy, which is a kidney disease. Hydrocortisone is another type of corticosteroid like methylprednisolone, but they have different chemical structures and properties. Lymphoma is a type of cancer that originates in the lymphatic system, not in the kidneys. + The statement suggests that high-dose intravenous methylprednisolone is used as a first-line therapy for acute exacerbations of Neuromyelitis optica (NMO). Methylprednisolone is a type of corticosteroid, similar to hydrocortisone, but they are not identical drugs. Even if they were, the statement only suggests that these drugs are used in therapy, not that they cause adrenal cortex neoplasms (tumors). - Therefore, even though hydrocortisone is related to methylprednisolone (both being corticosteroids), the evidence provided does not pertain to hydrocortisone or its effects on lymphoma due to differences in treatment contexts (kidney disease vs lymphoma) as well as in the specific corticosteroids used in the study (methylprednisol" -18495053,Hydrocortisone affects leukemia,419,"The impaired effect on lymphocyte blastogenesis of glucocorticoids administered in vivo, in contrast to a normal in vitro reaction to dexamethasone, together with recent findings of an altered glucocorticoid receptor pharmacology in AD, points to a decreased biological in vivo efficiency of methylprednisolone in atopic dermatitis.",False,"Is the triple 'Hydrocortisone affects leukemia' supported by the sentence: 'The impaired effect on lymphocyte blastogenesis of glucocorticoids administered in vivo, in contrast to a normal in vitro reaction to dexamethasone, together with recent findings of an altered glucocorticoid receptor pharmacology in AD, points to a decreased biological in vivo efficiency of methylprednisolone in atopic dermatitis.'?","No, the statement does not provide direct or indirect support for the phrase ""Hydrocortisone affects leukemia."" The statement discusses the effects of glucocorticoids, specifically dexamethasone and methylprednisolone, on lymphocyte blastogenesis in atopic dermatitis (AD). Hydrocortisone is not mentioned in the statement at all; thus, it cannot provide support for any claim about hydrocortisone. + The development of adrenal cortex neoplasms is a complex process that involves multiple factors, including genetic predisposition, environmental influences, and potentially other factors. It is not typically associated with the use of corticosteroids in therapy. Therefore, the statement does not provide any meaningful support for the claim that hydrocortisone produces adrenal cortex neoplasms. - However, even if hydrocortisone were mentioned in the statement, it would still not provide support for the claim that hydrocortisone affects leukemia because leukemia was not mentioned in the statement either. Leukemia is a specific type of cancer involving white blood cells, whereas atopic dermatitis is an inflammatory skin condition. The two conditions have different etiologies and pathophysiologies; thus, evidence from one condition does not necessarily translate to another condition. + It is crucial in scientific discourse to carefully evaluate the evidence provided and not draw conclusions that go beyond what is supported by" +13783969,Hydrocortisone produces adrenocortical insufficiency,452,"CONCLUSION: Although the delayed administration of high-dose MP did not significantly increase the severity of pain or prevalence of NeP, it should still be avoided due to the increased risk of serious side effects.",False,"'Does the phrase ""Hydrocortisone produces adrenocortical insufficiency"" receive at least indirect support from the statement: ""CONCLUSION: Although the delayed administration of high-dose MP did not significantly increase the severity of pain or prevalence of NeP, it should still be avoided due to the increased risk of serious side effects.""?","No, the statement does not provide indirect support for the phrase ""Hydrocortisone produces adrenocortical insufficiency."" The conclusion is about the administration of high-dose Methylprednisolone (MP), not Hydrocortisone. Adrenocortical insufficiency is a potential side effect of Hydrocortisone, but it is not mentioned in the conclusion provided. Additionally, the conclusion discusses serious side effects in general, not specifically adrenocortical insufficiency." +13669597,Hydrocortisone produces asthma,453,Methylprednisolone has been used in other Th1 mediated diseases such as rheumatoid arthritis in an attempt to switch off the immune response and so we investigated the efficacy of three days of high dose (1 g) intravenous methylprednisolone at the start of prednisolone therapy in leprosy Type 1 reactions and nerve function impairment.,False,"'Does the phrase ""Hydrocortisone produces asthma"" receive at least indirect support from the statement: ""Methylprednisolone has been used in other Th1 mediated diseases such as rheumatoid arthritis in an attempt to switch off the immune response and so we investigated the efficacy of three days of high dose (1 g) intravenous methylprednisolone at the start of prednisolone therapy in leprosy Type 1 reactions and nerve function impairment.""?","No, the statement does not provide indirect support for the phrase ""Hydrocortisone produces asthma."" The statement discusses the use of methylprednisolone in treating rheumatoid arthritis and leprosy Type 1 reactions, but it does not mention hydrocortisone or asthma at all. Hydrocortisone and methylprednisolone are both corticosteroids that can suppress immune responses, but they are not interchangeable in this context, and the effects of one cannot be inferred from the effects of the other. Furthermore, even if the statement had mentioned hydrocortisone in relation to asthma, it would still not provide conclusive evidence of causation but only an association at best, which is insufficient to support the claim that hydrocortisone produces asthma." +12147996,Hydrocortisone produces Sepsis,454,Myelitis in these patients was not related to graft versus host disease or immune reconstitution and was responsive to intravenous methylprednisolone and cyclophosphamide.,False,"'Does the phrase ""Hydrocortisone produces Sepsis"" receive at least indirect support from the statement: ""Myelitis in these patients was not related to graft versus host disease or immune reconstitution and was responsive to intravenous methylprednisolone and cyclophosphamide.""?","No, the statement does not provide any indirect support for the phrase ""Hydrocortisone produces Sepsis."" In fact, it seems to contradict it. The statement suggests that intravenous methylprednisolone (a type of corticosteroid like hydrocortisone) was used to treat myelitis in patients, implying that corticosteroids can be used to manage certain conditions rather than cause them. Sepsis is a serious condition that typically results from an overwhelming immune response to infection, not from the administration of hydrocortisone. Therefore, the statement does not support the idea that hydrocortisone produces sepsis." +11989948,Hydrocortisone produces Hypoxemia,455,"We investigated the effects of YM264, WEB2086, methylprednisolone and ticlopidine on puromycin-induced nephropathy in the rat.",False,"'Does the phrase ""Hydrocortisone produces Hypoxemia"" receive at least indirect support from the statement: ""We investigated the effects of YM264, WEB2086, methylprednisolone and ticlopidine on puromycin-induced nephropathy in the rat.""?","No, the statement does not provide any direct or indirect support for the phrase ""Hydrocortisone produces Hypoxemia"". The investigation focuses on the effects of various compounds on puromycin-induced nephropathy in rats, without any mention of hydrocortisone or hypoxemia in the context of this study. Hypoxemia refers to lower-than-normal levels of oxygen in the blood, while hydrocortisone is a type of corticosteroid hormone often used in medical treatments; these concepts aren't linked in any way by the provided statement." +11730055,Hydrocortisone produces pneumonia,456,"The study strongly suggests that methylprednisolone has significant beneficial effects in human spinal cord injury, that these effects occur only when the drug is given within 8 hr, and that it helps even in patients with severe spinal cord injuries.",False,"'Does the phrase ""Hydrocortisone produces pneumonia"" receive at least indirect support from the statement: ""The study strongly suggests that methylprednisolone has significant beneficial effects in human spinal cord injury, that these effects occur only when the drug is given within 8 hr, and that it helps even in patients with severe spinal cord injuries.""?","No, the statement does not provide indirect support for the phrase ""Hydrocortisone produces pneumonia."" The study in question focuses on methylprednisolone's effects on human spinal cord injury, not hydrocortisone. Hydrocortisone and methylprednisolone are both corticosteroids, but they have different properties and uses. Therefore, any conclusions drawn from this study about methylprednisolone cannot be automatically applied to hydrocortisone. - Therefore, based on the provided statement alone, it is not possible to conclude that hydrocortisone has any effect on leukemia. Additional evidence would be needed to" -18310128,Hydrocortisone affects toxic shock syndrome,420,"CONCLUSION: In this single-center trial, combined vasopressin-epinephrine and methylprednisolone during resuscitation and stress-dose hydrocortisone in postresuscitation shock improved survival in refractory in-hospital cardiac arrest.",True,"Is the triple 'Hydrocortisone affects toxic shock syndrome' supported by the sentence: 'CONCLUSION: In this single-center trial, combined vasopressin-epinephrine and methylprednisolone during resuscitation and stress-dose hydrocortisone in postresuscitation shock improved survival in refractory in-hospital cardiac arrest.'?","Yes, there is indirect support for the statement that ""hydrocortisone affects toxic shock syndrome"" based on the provided conclusion from a single-center trial. The conclusion suggests that hydrocortisone administration in postresuscitation shock improves survival rates in refractory in-hospital cardiac arrest patients who received vasopressin-epinephrine and methylprednisolone during resuscitation. + Furthermore, while the study suggests that methylprednisolone has beneficial effects in spinal cord injury when given within 8 hours, it does not mention any adverse effects such as pneumonia associated with its use. Even if the study had mentioned hydrocortisone instead of methylprednisolone, it still would not provide indirect support for ""Hydrocortisone produces pneumonia"" without evidence of such an association being made in the study itself." +8328567,Hydrocortisone produces prostate cancer,457,"Comparison of the effects of 2 doses of methylprednisolone on pain, swelling, and trismus after third molar surgery.",False,"'Does the phrase ""Hydrocortisone produces prostate cancer"" receive at least indirect support from the statement: ""Comparison of the effects of 2 doses of methylprednisolone on pain, swelling, and trismus after third molar surgery.""?","No, the statement does not provide any indirect support for the phrase ""Hydrocortisone produces prostate cancer."" The statement discusses a comparison of two doses of methylprednisolone on pain, swelling, and trismus after third molar surgery. Methylprednisolone is a synthetic glucocorticoid, similar to hydrocortisone, but it is not hydrocortisone itself. Moreover, the study does not involve prostate cancer or any other type of cancer. Therefore, there is no connection between the two statements in terms of subject matter or implications." +8077250,Hydrocortisone produces neoplasm,458,Steatohepatitis during methylprednisolone therapy for ulcerative colitis exacerbation.,False,"'Does the phrase ""Hydrocortisone produces neoplasm"" receive at least indirect support from the statement: ""Steatohepatitis during methylprednisolone therapy for ulcerative colitis exacerbation.""?","No, the statement ""Steatohepatitis during methylprednisolone therapy for ulcerative colitis exacerbation"" does not provide indirect support for the phrase ""Hydrocortisone produces neoplasm."" - - Although toxic shock syndrome is not explicitly mentioned in the conclusion, hydrocortisone has been used as an adjunctive treatment for toxic shock syndrome due to its anti-inflammatory properties (Slade et al., 2017). The evidence from this trial indirectly supports hydrocortisone's potential benefits in treating severe inflammatory conditions such as toxic shock syndrome by demonstrating its positive impact on survival rates in critically ill patients experiencing cardiac arrest. + The statement discusses steatohepatitis, which is a type of liver disease characterized by fat accumulation in liver cells, during methylprednisolone therapy for ulcerative colitis exacerbation. Methylprednisolone is a synthetic glucocorticoid, structurally related to hydrocortisone but having greater anti-inflammatory activity due to its reduced catabolism in the body. - - However, it is essential to acknowledge that further investigation is required to establish a direct causal relationship between hydrocortisone administration and improvements in toxic shock syndrome specifically. The provided conclusion does not explicitly link hydrocortisone use to toxic shock syndrome but rather" -17910566,Hydrocortisone affects atopic eczema,421,Weekly bortezomib/methylprednisolone is effective and well tolerated in relapsed multiple myeloma.,False,Is the triple 'Hydrocortisone affects atopic eczema' supported by the sentence: 'Weekly bortezomib/methylprednisolone is effective and well tolerated in relapsed multiple myeloma.'?,"No, the statement ""Weekly bortezomib/methylprednisolone is effective and well tolerated in relapsed multiple myeloma"" does not provide indirect support for the claim that ""Hydrocortisone affects atopic eczema."" + While glucocorticoids like hydrocortisone and methylprednisolone have been linked to various side effects including metabolic disorders like steatohepatitis, there is no direct mention of neoplasm (abnormal tissue growth that may lead to cancer) in the statement provided. - - The two statements discuss different medical conditions (atopic eczema vs multiple myeloma) and different medications (hydrocortisone vs bortezomib/methylprednisolone). The effectiveness of bortezomib/methylprednisolone in treating multiple myeloma does not imply that hydrocortisone would have any effect on atopic eczema. + Moreover, associating steroid use with neoplasm development is complex as some studies have reported an increased risk of certain cancers due to steroid use, while others have not found such" +27711985,Hydrocortisone disrupts adrenocortical insufficiency,459,These results suggest that increasing the uric acid concentration may represent one of the possible mechanisms of action of methylprednisolone in multiple sclerosis.,False,"'Does the phrase ""Hydrocortisone disrupts adrenocortical insufficiency"" receive at least indirect support from the statement: ""These results suggest that increasing the uric acid concentration may represent one of the possible mechanisms of action of methylprednisolone in multiple sclerosis.""?","No, the statement does not provide indirect support for the phrase ""Hydrocortisone disrupts adrenocortical insufficiency."" The statement discusses methylprednisolone, which is a glucocorticoid like hydrocortisone but is not hydrocortisone itself. It suggests that methylprednisolone may increase uric acid concentration as one of its possible mechanisms of action in multiple sclerosis treatment. This has no direct bearing on adrenocortical insufficiency, which is a condition characterized by insufficient production of corticosteroids by the adrenal glands. Hydrocortisone is used as replacement therapy in adrenocortical insufficiency but is not known for disrupting it as such. The two statements discuss different concepts and drugs in separate contexts." +26428860,Hydrocortisone disrupts leukemia,460,"OBJECTIVE: Compare the therapeutic efficacy of an oral/metered-dose inhaler (oral/MDI) regimen to an intravenous/nebulizer (I.V./neb) regimen of methylprednisolone, cefuroxime, and inhaled albuterol and ipratropium bromide in patients hospitalized for exacerbations of chronic obstructive pulmonary disease (COPD).",False,"'Does the phrase ""Hydrocortisone disrupts leukemia"" receive at least indirect support from the statement: ""OBJECTIVE: Compare the therapeutic efficacy of an oral/metered-dose inhaler (oral/MDI) regimen to an intravenous/nebulizer (I.V./neb) regimen of methylprednisolone, cefuroxime, and inhaled albuterol and ipratropium bromide in patients hospitalized for exacerbations of chronic obstructive pulmonary disease (COPD).""?","No, the statement does not provide indirect support for the phrase ""Hydrocortisone disrupts leukemia."" The objective in the statement focuses on comparing different treatment regimens for chronic obstructive pulmonary disease (COPD) exacerbations, including methylprednisolone (a glucocorticoid like hydrocortisone) but not hydrocortisone itself nor any reference to leukemia. The lack of connection between COPD treatments and leukemia undermines any potential indirect support for the given phrase." +26389045,Hydrocortisone disrupts neoplasm,461,"Similar to the CRPS clinical response to glucocorticoids, we now demonstrate that chronic hindpaw edema in the sciatic transection CRPS model is reversed by a continuous infusion of MP (3 mg/kg/day over 21 days), and this anti-edematous effect persists for at least 1 week after discontinuing MP.",False,"'Does the phrase ""Hydrocortisone disrupts neoplasm"" receive at least indirect support from the statement: ""Similar to the CRPS clinical response to glucocorticoids, we now demonstrate that chronic hindpaw edema in the sciatic transection CRPS model is reversed by a continuous infusion of MP (3 mg/kg/day over 21 days), and this anti-edematous effect persists for at least 1 week after discontinuing MP.""?","No, the statement does not provide indirect support for the phrase ""Hydrocortisone disrupts neoplasm."" The statement discusses the effects of MP (Methylprednisolone), a type of glucocorticoid, on chronic hindpaw edema in a specific rat model of Complex Regional Pain Syndrome (CRPS). Hydrocortisone is also a glucocorticoid, but the statement does not mention it nor does it imply that the effects of MP would translate to Hydrocortisone. Furthermore, neoplasm refers to new and abnormal growth of tissue, such as cancerous tumors, which is not addressed in the statement. Therefore, there is no reasonable basis to infer that Hydrocortisone disrupts neoplasm from this statement." +26128287,Hydrocortisone disrupts melanoma,462,STUDY OBJECTIVES: To assess whether IV methylprednisolone exerts a specific early effect on dyspnea in patients with an exacerbation of asthma.,False,"'Does the phrase ""Hydrocortisone disrupts melanoma"" receive at least indirect support from the statement: ""STUDY OBJECTIVES: To assess whether IV methylprednisolone exerts a specific early effect on dyspnea in patients with an exacerbation of asthma.""?","No, the statement does not provide indirect support for the phrase ""Hydrocortisone disrupts melanoma."" The study objective is assessing the effect of intravenous methylprednisolone on dyspnea in patients with an exacerbation of asthma. This objective does not involve hydrocortisone or melanoma in any way, so it does not provide any relevant context or evidence that would support the claim about hydrocortisone disrupting melanoma." +21020907,Hydrocortisone disrupts pneumonia,463,REVIEWER'S CONCLUSIONS: Cyclophosphamide regimen treatment is a form of care in neuropsychiatric involvement in systemic lupus erythematosus with no evidence to prove better effectiveness and safety when compared with methylprednisolone.,False,"'Does the phrase ""Hydrocortisone disrupts pneumonia"" receive at least indirect support from the statement: ""REVIEWER'S CONCLUSIONS: Cyclophosphamide regimen treatment is a form of care in neuropsychiatric involvement in systemic lupus erythematosus with no evidence to prove better effectiveness and safety when compared with methylprednisolone.""?","No, the statement does not provide indirect support for the phrase ""Hydrocortisone disrupts pneumonia."" The reviewer's conclusion is comparing two different treatments (cyclophosphamide regimen treatment and methylprednisolone) for neuropsychiatric involvement in systemic lupus erythematosus (SLE). Hydrocortisone is a type of corticosteroid like methylprednisolone, but it is not mentioned in the reviewer's conclusion, nor is there any reference made to its effect on pneumonia in this context. - - The only potential connection between these two statements could be through methylprednisolone, which is a type of corticosteroid like hydrocortisone. Both medications can have immunosuppressive effects, but they have different potencies, durations of action, and routes of administration, which could lead to different therapeutic effects in different diseases like atopic eczema vs multiple myeloma. + To provide indirect support for ""Hydrocortisone disrupts pneumonia,"" there would need to be some mention of hydrocortisone negatively impacting pneumonia patients in either the treatment comparison or in other parts of the statement. In its absence, there is no valid connection to be made between these two separate pieces of information." +15895489,Hydrocortisone disrupts obesity disorder,464,"RESULTS: Both methylprednisolone and dexamethasone significantly reduced swelling and trismus (P < .05, Kruskal-Wallis test), whereas the methylprednisolone group had significantly less pain (P < .05, Kruskal-Wallis test) and consumed a lower amount of analgesics (P < .05, chi2 test) during the early postoperative days.",False,"'Does the phrase ""Hydrocortisone disrupts obesity disorder"" receive at least indirect support from the statement: ""RESULTS: Both methylprednisolone and dexamethasone significantly reduced swelling and trismus (P < .05, Kruskal-Wallis test), whereas the methylprednisolone group had significantly less pain (P < .05, Kruskal-Wallis test) and consumed a lower amount of analgesics (P < .05, chi2 test) during the early postoperative days.""?","No, the statement does not provide indirect support for the phrase ""Hydrocortisone disrupts obesity disorder."" The statement presents results from a study investigating the effects of two different corticosteroids (methylprednisolone and dexamethasone) on swelling, trismus, pain, and analgesic consumption in early postoperative days. Hydrocortisone is not one of the corticosteroids mentioned in the statement; therefore, it does not support any claim about hydrocortisone's impact on obesity disorder. - - Therefore, without further evidence connecting hydrocort" -15925719,Hydrocortisone affects Inflammation,422,Amsacrine combined with etoposide and high-dose methylprednisolone as salvage therapy in acute lymphoblastic leukemia in children.,False,Is the triple 'Hydrocortisone affects Inflammation' supported by the sentence: 'Amsacrine combined with etoposide and high-dose methylprednisolone as salvage therapy in acute lymphoblastic leukemia in children.'?,"No, the statement does not provide direct or indirect support for the phrase ""Hydrocortisone affects Inflammation."" The statement discusses a therapeutic approach using Amsacrine, etoposide, and high-dose methylprednisolone for treating acute lymphoblastic leukemia in children. Methylprednisolone is a type of corticosteroid similar to hydrocortisone; however, it does not necessarily imply that hydrocortisone has an effect on inflammation within the context provided. To establish support for that phrase, there would need to be specific evidence linking hydrocortisone to inflammation modulation." -14970164,Hydrocortisone affects Insulin resistance,423,Controlled clinical trial of IV cyclophosphamide versus IV methylprednisolone in severe neurological manifestations in systemic lupus erythematosus.,False,Is the triple 'Hydrocortisone affects Insulin resistance' supported by the sentence: 'Controlled clinical trial of IV cyclophosphamide versus IV methylprednisolone in severe neurological manifestations in systemic lupus erythematosus.'?,"No, the statement does not provide direct or indirect support for the phrase ""Hydrocortisone affects Insulin resistance."" The clinical trial mentioned in the statement compares two different treatments for severe neurological manifestations in systemic lupus erythematosus (SLE), one of which includes methylprednisolone, a corticosteroid like hydrocortisone. However, it does not provide any information on insulin resistance or how either treatment affects it. Insulin resistance is a condition in which cells do not respond properly to insulin, leading to high blood sugar levels. Hydrocortisone is known to have potential metabolic side effects such as increasing blood glucose levels, but its direct impact on insulin resistance remains an area for further investigation." -14804311,Hydrocortisone affects injury,424,Delayed hypersensitivity to 6-methyl-prednisolone in Henoch Schoenlein syndrome.,False,Is the triple 'Hydrocortisone affects injury' supported by the sentence: 'Delayed hypersensitivity to 6-methyl-prednisolone in Henoch Schoenlein syndrome.'?,"No, the statement ""Delayed hypersensitivity to 6-methyl-prednisolone in Henoch Schoenlein syndrome"" does not provide direct or indirect support for the phrase ""Hydrocortisone affects injury."" Hydrocortisone and 6-methyl-prednisolone are both glucocorticoids but they are different compounds with distinct properties. While the statement implies that glucocorticoids like 6-methyl-prednisolone may have an effect on immune response in Henoch Schoenlein syndrome, it does not provide evidence that hydrocortisone in particular influences injury. Further investigation into hydrocortisone-specific studies would be required for such validation." -14533429,Hydrocortisone affects hypotensive disorder,425,Rectal absorption of radioactive 6-alpha-methyl prednisolone in ulcerative colitis.,False,Is the triple 'Hydrocortisone affects hypotensive disorder' supported by the sentence: 'Rectal absorption of radioactive 6-alpha-methyl prednisolone in ulcerative colitis.'?,"No, the statement ""Rectal absorption of radioactive 6-alpha-methyl prednisolone in ulcerative colitis"" does not provide direct or indirect support for the claim that ""Hydrocortisone affects hypotensive disorder."" + To establish indirect support for ""Hydrocortisone disrupts obesity disorder,"" there would need to be some connection between hydrocortisone and obesity disorder in either the provided statement or existing literature. The statement only discusses methylprednisolone and dexamethasone; therefore, it does not offer any indirect support for the claim about hydrocortisone. - The reason is that these two statements refer to different corticosteroids (Hydrocortisone vs 6-alpha-methyl prednisolone) and different medical conditions (hypotensive disorder vs ulcerative colitis). The absorption of one steroid in treating ulcerative colitis does not inherently imply an effect on blood pressure regulation by another steroid. + While it is true that hydrocortisone is another type of corticosteroid like methylprednisolone and dexamethasone, it does not automatically imply that hydrocort" +15750557,Hydrocortisone disrupts injury,465,Methylprednisolone only inhibited granulocytopenia and thrombocytopenia when zymosan-activated serum or fibrinogen-depleted plasma were infused.,False,"'Does the phrase ""Hydrocortisone disrupts injury"" receive at least indirect support from the statement: ""Methylprednisolone only inhibited granulocytopenia and thrombocytopenia when zymosan-activated serum or fibrinogen-depleted plasma were infused.""?","No, the statement does not provide indirect support for the phrase ""Hydrocortisone disrupts injury."" The statement discusses the effects of Methylprednisolone on granulocytopenia and thrombocytopenia when certain substances are infused. Hydrocortisone is not mentioned in the statement, so there is no connection that can be made between the two pieces of information. Furthermore, the statement does not discuss any potential effects of Methylprednisolone or Hydrocortisone on injury, making it even less likely that there is any relevant connection between the two pieces of information." +8865955,Hydrocortisone disrupts Inflammation,466,"In addition, we detected that sufentanil provided prolonged pain relief up to 24 h when compared with control, whereas when we combined sufentanil plus methylprednisolone, we found that it further reduced pain and use of analgesics when compared with sufentanil.",False,"'Does the phrase ""Hydrocortisone disrupts Inflammation"" receive at least indirect support from the statement: ""In addition, we detected that sufentanil provided prolonged pain relief up to 24 h when compared with control, whereas when we combined sufentanil plus methylprednisolone, we found that it further reduced pain and use of analgesics when compared with sufentanil.""?","No, the statement does not provide indirect support for the phrase ""Hydrocortisone disrupts Inflammation"". The statement discusses the effects of sufentanil and methylprednisolone on pain relief and use of analgesics, but it does not mention hydrocortisone or inflammation. Methylprednisolone is a glucocorticoid like hydrocortisone, but they are not interchangeable in this context because the statement does not specify whether methylprednisolone has anti-inflammatory effects in this particular experiment. Therefore, we cannot infer any relationship between hydrocortisone and inflammation disruption based on this information alone." +26205555,Hydrocortisone prevents neoplasm,467,These findings demonstrate that MP may suppress post-traumatic inflammatory reaction by inhibiting both the AP-1 and NF-kappaB transcription cascades via a GR mechanism.,False,"'Does the phrase ""Hydrocortisone prevents neoplasm"" receive at least indirect support from the statement: ""These findings demonstrate that MP may suppress post-traumatic inflammatory reaction by inhibiting both the AP-1 and NF-kappaB transcription cascades via a GR mechanism.""?","No, the statement does not provide direct or indirect support for the phrase ""Hydrocortisone prevents neoplasm."" The initial statement discusses how Methylprednisolone (MP) may potentially suppress post-traumatic inflammatory reactions by inhibiting certain transcription cascades through a glucocorticoid receptor (GR) mechanism. Although both hydrocortisone and methylprednisolone are glucocorticoids that can act via GR mechanisms, there is no explicit mention of hydrocortisone in relation to neoplasm suppression in this statement. - However, it is important to note that both hydrocortisone and 6-alpha-methyl prednisolone belong to the class of corticosteroids that can influence various physiological processes in the human body due to their anti-inflammatory properties. Nonetheless, specific experimental evidence would be required to establish any connection between hydrocortisone use and hypotensive disorder management." -13999195,Hydrocortisone affects congenital adrenal hyperplasia,426,Controlled trial of pulse methylprednisolone versus two regimens of pulse cyclophosphamide in severe lupus nephritis.,False,Is the triple 'Hydrocortisone affects congenital adrenal hyperplasia' supported by the sentence: 'Controlled trial of pulse methylprednisolone versus two regimens of pulse cyclophosphamide in severe lupus nephritis.'?,"No, the statement does not provide any direct or indirect support for the phrase ""Hydrocortisone affects congenital adrenal hyperplasia."" The study mentioned is focused on comparing pulse methylprednisolone with two regimens of pulse cyclophosphamide in treating severe lupus nephritis. Hydrocortisone is not mentioned in the study, nor is congenital adrenal hyperplasia (CAH) explicitly discussed. + To establish support for hydrocortisone preventing neoplasm (abnormal tissue growth), evidence should demonstrate that hydrocortisone specifically suppresses neoplasm development through its GR mechanism. The current statement focuses on MP suppressing post-traumatic inflammatory reactions; hence it does not provide any relevant information regarding hydrocortisone and neoplasm prevention." +19342068,Hydrocortisone prevents obesity disorder,468,"This study assessed the effectiveness of a ganciclovir, methylprednisolone, and immunoglobulin combination (TAGMIC) therapy in decreasing cognitive impairment and mortality among patients with Japanese encephalitis.",False,"'Does the phrase ""Hydrocortisone prevents obesity disorder"" receive at least indirect support from the statement: ""This study assessed the effectiveness of a ganciclovir, methylprednisolone, and immunoglobulin combination (TAGMIC) therapy in decreasing cognitive impairment and mortality among patients with Japanese encephalitis.""?","No, the statement does not provide indirect support for the claim that ""Hydrocortisone prevents obesity disorder."" The study mentioned in the statement is focused on assessing the effectiveness of TAGMIC therapy in decreasing cognitive impairment and mortality among patients with Japanese encephalitis. Hydrocortisone is not mentioned in the study statement, nor is there any connection made between TAGMIC therapy or Japanese encephalitis and obesity disorder prevention. Therefore, there is no indirect support for the claim based on the provided statement." +19245686,Hydrocortisone prevents toxic shock syndrome,469,"From indirect comparisons, most interventions showed decreased risk of developing RA compared to placebo at 12 months, reaching statistical significance for methotrexate (OR 0.16 [95% CI 0.08, 0.33]) and intramuscular methylprednisolone (OR 0.72 [95% CI 0.53, 0.99]).",False,"'Does the phrase ""Hydrocortisone prevents toxic shock syndrome"" receive at least indirect support from the statement: ""From indirect comparisons, most interventions showed decreased risk of developing RA compared to placebo at 12 months, reaching statistical significance for methotrexate (OR 0.16 [95% CI 0.08, 0.33]) and intramuscular methylprednisolone (OR 0.72 [95% CI 0.53, 0.99]).""?","No, the statement does not provide indirect support for the claim that hydrocortisone prevents toxic shock syndrome. The statement discusses the use of methotrexate and intramuscular methylprednisolone in reducing the risk of developing rheumatoid arthritis (RA) at 12 months. Hydrocortisone is not mentioned in the statement, nor is toxic shock syndrome. Therefore, there is no connection that can be drawn between the two statements to support the claim about hydrocortisone and toxic shock syndrome." +18758297,Hydrocortisone prevents injury,470,Treatment with a pulse of methylprednisolone reduced both abdominal pain and lesion size.,False,"'Does the phrase ""Hydrocortisone prevents injury"" receive at least indirect support from the statement: ""Treatment with a pulse of methylprednisolone reduced both abdominal pain and lesion size.""?","No, the statement does not provide indirect support for the phrase ""Hydrocortisone prevents injury."" Methylprednisolone and hydrocortisone are two different types of corticosteroids that have overlapping yet distinct effects on the body. While both can reduce inflammation and modulate immune responses, they have different therapeutic indications and administration regimens. - Although hydrocortisone is a glucocorticoid like methylprednisolone, which is used in the study, there is no mention of any specific interactions between these medications and congenital adrenal hyperplasia in humans or animal models. Thus, it is not possible to infer any support for that specific claim based on the provided statement alone. + The statement given refers specifically to treatment with methylprednisolone, which resulted in reduced abdominal pain and lesion size in an unspecified context. Although corticosteroids like methylprednisolone and hydrocortisone share some mechanisms of action that may contribute to their observed effects in various clinical settings, it does not automatically imply that hydrocortisone would prevent injury under similar circumstances without explicit evidence demonstrating its efficacy in that context. - However, it is important to note that hydrocortisone has been used in treating congenital adrenal hyperplasia due to its glucocorticoid properties in managing adrenal insufficiency (Speiser et al., 2008). Nonetheless, the given statement does not provide any evidence for" -13347553,Hydrocortisone affects asthma,427,"The National Heart, Lung, and Blood Institute's ARDS Network currently is testing the use of methylprednisolone in late ARDS.",False,"Is the triple 'Hydrocortisone affects asthma' supported by the sentence: 'The National Heart, Lung, and Blood Institute's ARDS Network currently is testing the use of methylprednisolone in late ARDS.'?","No, the statement does not provide indirect support for the phrase ""Hydrocortisone affects asthma."" The National Heart, Lung, and Blood Institute's ARDS Network is testing methylprednisolone in late ARDS (Acute Respiratory Distress Syndrome), not hydrocortisone. Although methylprednisolone and hydrocortisone are both corticosteroids that can potentially influence inflammation and immune response in various conditions such as asthma and ARDS, they have distinct pharmacological properties, dosages, and therapeutic indications. + Therefore, it is crucial to evaluate each corticosteroid individually based on available evidence specific to its use in preventing injury rather than extrapolating results from one corticosteroid class member (methylprednisolone) to another (hydrocortisone)." +17956690,Hydrocortisone prevents Sepsis,471,Methylprednisolone prevents propranolol-induced airway hyperreactivity in the Basenji-greyhound dog.,False,"'Does the phrase ""Hydrocortisone prevents Sepsis"" receive at least indirect support from the statement: ""Methylprednisolone prevents propranolol-induced airway hyperreactivity in the Basenji-greyhound dog.""?","No, the statement ""Methylprednisolone prevents propranolol-induced airway hyperreactivity in the Basenji-greyhound dog"" does not provide indirect support for the claim that ""Hydrocortisone prevents Sepsis."" - The statement only implies that corticosteroids like methylprednisolone might have an effect on ARDS, but it does not necessarily extend that conclusion to hydrocortisone or asthma without additional information linking these specific components together. Therefore, it is essential to rely on direct evidence that specifically investigates hydrocortisone's impact on asthma when addressing that particular claim." -13180935,Hydrocortisone affects hypotensive disorder,428,"(3) Preliminary results of an interim analysis from an ongoing randomized, prospective study showed that methylprednisolone (plus an antiviral agent?) may be useful for improving peripheral vestibular function in vestibular neuritis.",False,"Is the triple 'Hydrocortisone affects hypotensive disorder' supported by the sentence: '(3) Preliminary results of an interim analysis from an ongoing randomized, prospective study showed that methylprednisolone (plus an antiviral agent?) may be useful for improving peripheral vestibular function in vestibular neuritis.'?","No, the statement does not provide direct or indirect support for the phrase ""Hydrocortisone affects hypotensive disorder."" The study refers to methylprednisolone, which is a glucocorticoid like hydrocortisone but not hydrocortisone itself. Additionally, the study focuses on vestibular neuritis and peripheral vestibular function, not hypotensive disorder." -11695335,Hydrocortisone affects Hypoxemia,429,This is the first report of cyclophosphamide and methylprednisolone leading to complete and sustained resolution of GAVE in association with systemic sclerosis.,False,Is the triple 'Hydrocortisone affects Hypoxemia' supported by the sentence: 'This is the first report of cyclophosphamide and methylprednisolone leading to complete and sustained resolution of GAVE in association with systemic sclerosis.'?,"No, the statement does not provide any direct or indirect support for the phrase ""Hydrocortisone affects Hypoxemia"". The statement discusses the effects of cyclophosphamide and methylprednisolone on gastrointestinal arterial vasospasm (GAVE) associated with systemic sclerosis. Hypoxemia is a condition characterized by low oxygen levels in the blood, while hydrocortisone is a type of steroid hormone often used for its anti-inflammatory effects. The two concepts are not connected in the given statement." -11304252,Hydrocortisone affects obesity disorder,430,We compared lymphocyte-suppressive potencies of prednisolone and methylprednisolone in rheumatoid arthritis (RA).,False,Is the triple 'Hydrocortisone affects obesity disorder' supported by the sentence: 'We compared lymphocyte-suppressive potencies of prednisolone and methylprednisolone in rheumatoid arthritis (RA).'?,"No, the statement does not provide direct or indirect support for the phrase ""Hydrocortisone affects obesity disorder"". The statement discusses a comparison of lymphocyte-suppressive potencies between prednisolone and methylprednisolone in rheumatoid arthritis (RA). Hydrocortisone is not mentioned in the statement; therefore, there is no basis for inferring any relationship between hydrocortisone and obesity disorder based on this statement alone. + The reason is that while both hydrocortisone and methylprednisolone belong to the class of glucocorticoids (a type of steroid hormone) commonly used as anti-inflammatory agents, they have different mechanisms of action and therapeutic applications. - - To establish whether hydrocortisone affects obesity disorder, one would need specific studies that investigate any potential link between hydrocortisone use and obesity outcomes. Additionally, animal studies would need to be complemented by human studies for stronger evidence. The current statement does not provide any such information, making it impossible to draw any conclusions about hydrocortisone's effects on obesity disorder based on this statement alone." -10523644,Hydrocortisone affects injury,431,"Despite the lucrative ""off label"" markets for methylprednisolone in SCI, no Food and Drug Association indication has been obtained.",False,"Is the triple 'Hydrocortisone affects injury' supported by the sentence: 'Despite the lucrative ""off label"" markets for methylprednisolone in SCI, no Food and Drug Association indication has been obtained.'?","No, the statement does not provide indirect support for the phrase ""Hydrocortisone affects injury."" The statement discusses methylprednisolone use in spinal cord injuries (SCI) and its lack of Food and Drug Administration (FDA) indication despite lucrative off-label markets. Hydrocortisone is a different glucocorticoid than methylprednisolone, and no information is provided about its effects on injury in general or specifically on SCI. The two statements discuss different steroids in different contexts; therefore, no indirect support can be inferred for ""Hydrocortisone affects injury.""" -10431364,Hydrocortisone affects Inflammation,432,Extraocular muscle responses to high dose intravenous methylprednisolone in myasthenia gravis.,False,Is the triple 'Hydrocortisone affects Inflammation' supported by the sentence: 'Extraocular muscle responses to high dose intravenous methylprednisolone in myasthenia gravis.'?,"No, I would argue that the statement ""Extraocular muscle responses to high dose intravenous methylprednisolone in myasthenia gravis"" does not provide direct or indirect support for the claim ""Hydrocortisone affects Inflammation."" + Methylprednisolone is used primarily for its potent anti-inflammatory effects in conditions like asthma, whereas hydrocortisone is often used in treating allergic reactions and as a replacement therapy in adrenal insufficiency due to its glucocorticoid and mineralocorticoid activities. - The reason is that methylprednisolone and hydrocortisone are both corticosteroids but they have different chemical structures and pharmacological properties. Methylprednisolone is primarily used as an anti-inflammatory drug, while hydrocortisone is used as an anti-inflammatory as well as a replacement for natural cortisol in patients with adrenal insufficiency. + Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. Although glucocorticoids have been investigated in sepsis trials due to their potential for modulating inflammation, current evidence does not support" +16963888,Hydrocortisone prevents adrenocortical insufficiency,472,Administration of methylprednisolone to prevent severe ovarian hyperstimulation syndrome in patients undergoing in vitro fertilization.,True,"'Does the phrase ""Hydrocortisone prevents adrenocortical insufficiency"" receive at least indirect support from the statement: ""Administration of methylprednisolone to prevent severe ovarian hyperstimulation syndrome in patients undergoing in vitro fertilization.""?","Yes, there is indirect support for the claim that hydrocortisone prevents adrenocortical insufficiency based on the provided statement about methylprednisolone use in patients undergoing in vitro fertilization (IVF). - The statement in question discusses the effects of methylprednisolone on extraocular muscle responses in myasthenia gravis, which is an autoimmune disease characterized by muscle weakness. While both methylprednisolone and hydrocortisone have anti-inflammatory effects, they do not necessarily imply that hydrocortisone specifically affects inflammation in the same context as stated in the claim. + Justification: - To provide indirect support for the claim" -10074536,Hydrocortisone affects HIV infectious disease,433,The increased CSF levels of TNF-sRp55 in response to MP circumstantially suggest that this receptor could partially account for the beneficial effects of MP in acute MS.,False,Is the triple 'Hydrocortisone affects HIV infectious disease' supported by the sentence: 'The increased CSF levels of TNF-sRp55 in response to MP circumstantially suggest that this receptor could partially account for the beneficial effects of MP in acute MS.'?,"No, the statement does not provide indirect support for the phrase ""Hydrocortisone affects HIV infectious disease."" The statement discusses the potential role of microglial proliferation (MP) in multiple sclerosis (MS) and how hydrocortisone (CSF levels) might influence TNF-sRp55 receptors in that context. There is no mention or implication of HIV infectious disease in this statement." -9872405,Hydrocortisone affects toxic shock syndrome,434,"Such an effect has been demonstrated between clarithromycin and methylprednisolone, two drugs that may be administered concomitantly in asthma.",False,"Is the triple 'Hydrocortisone affects toxic shock syndrome' supported by the sentence: 'Such an effect has been demonstrated between clarithromycin and methylprednisolone, two drugs that may be administered concomitantly in asthma.'?","No, the statement does not provide indirect support for the claim that hydrocortisone affects toxic shock syndrome based on the provided context. The statement mentions an interaction between clarithromycin and methylprednisolone in asthma patients but does not mention hydrocortisone nor toxic shock syndrome. + + Both hydrocortisone and methylprednisolone belong to the same class of medications called glucocorticoids, which act on the adrenal gland by binding to glucocorticoid receptors. These medications can help prevent adrenocortical insufficiency by mimicking the effects of natural hormones produced by the adrenal gland. - To establish indirect support for the claim, there should be some connection between hydrocortisone, toxic shock syndrome, and either clarithromycin or methylprednisolone in the statement. However, no such connection exists in the given context. + In the given statement about methylprednisolone use in IVF patients, it suggests that administering methylprednisolone can help prevent severe ovarian hyperstimulation syndrome (OHSS), which is an iatrogenic complication of controlled ovarian stimulation in assisted reproductive technology (ART) treatments such as IVF. Although OHSS is not primarily caused by adrenocortical insufficiency, it is associated with an increased risk of developing adrenal crisis" +15550113,Hydrocortisone prevents Inflammation,473,"Combined methylprednisolone, bupivacaine and morphine reduced pain, joint swelling, time of immobilization, duration of sick leave and return to sports after the arthroscopic procedure.",False,"'Does the phrase ""Hydrocortisone prevents Inflammation"" receive at least indirect support from the statement: ""Combined methylprednisolone, bupivacaine and morphine reduced pain, joint swelling, time of immobilization, duration of sick leave and return to sports after the arthroscopic procedure.""?","No, the statement does not provide direct or indirect support for the phrase ""Hydrocortisone prevents Inflammation."" The statement refers to a study where methylprednisolone, bupivacaine, and morphine were used in combination for reducing pain, joint swelling, time of immobilization, duration of sick leave, and return to sports after an arthroscopic procedure. Methylprednisolone is a glucocorticoid like hydrocortisone, but it is not hydrocortisone itself. Additionally, even though both hydrocortisone and methylprednisolone have anti-inflammatory properties, demonstrating that methylprednisolone reduces inflammation does not automatically imply that hydrocortisone would have an identical effect in similar circumstances. - Nevertheless, it is important to note that hydrocortisone is a glucocorticoid that can be used in treating toxic shock syndrome due to its anti-inflammatory properties; however, that does not imply that hydrocortisone has an effect on toxic shock syndrome itself but rather alleviates some symptoms by reducing inflammation." -9610203,Hydrocortisone affects neoplasm,435,"In this study, low-dose methylprednisolone (0.8 mg/kg/day, MP) was used to induce a steroid-resistant lupus nephritis (SR-LN) mouse model in weeks one to four, and a therapeutic steroid dosage (MP 12 mg/kg/day) or a combined PNS (PNS 100 mg/kg/day) treatment was administered from week five to eight.",False,"Is the triple 'Hydrocortisone affects neoplasm' supported by the sentence: 'In this study, low-dose methylprednisolone (0.8 mg/kg/day, MP) was used to induce a steroid-resistant lupus nephritis (SR-LN) mouse model in weeks one to four, and a therapeutic steroid dosage (MP 12 mg/kg/day) or a combined PNS (PNS 100 mg/kg/day) treatment was administered from week five to eight.'?","No, the statement does not provide direct or indirect support for the phrase ""Hydrocortisone affects neoplasm."" The study mentioned uses methylprednisolone (MP), not hydrocortisone, in a mouse model for lupus nephritis. A neoplasm refers to an abnormal growth of tissue, which is not addressed in the given context. Therefore, it is inappropriate to draw conclusions about hydrocortisone's effect on neoplasm based on this information alone." -9120606,Hydrocortisone affects asthma,436,MP was administrated in three alternative ways: intraperitoneally during the induction of cytotoxic edema or immediately after finishing cytotoxic edema induction in a dose of 100 mg/kg b.w.; into the internal carotid artery within 2 h after finishing cytotoxic edema induction in a dose of 50 mg/kg b.w.; into internal carotid artery 10 min after edema induction by BBBd in a dose of 50 mg/kg b.w.,False,Is the triple 'Hydrocortisone affects asthma' supported by the sentence: 'MP was administrated in three alternative ways: intraperitoneally during the induction of cytotoxic edema or immediately after finishing cytotoxic edema induction in a dose of 100 mg/kg b.w.; into the internal carotid artery within 2 h after finishing cytotoxic edema induction in a dose of 50 mg/kg b.w.; into internal carotid artery 10 min after edema induction by BBBd in a dose of 50 mg/kg b.w.'?,"No, the statement does not provide direct support for the phrase ""Hydrocortisone affects asthma."" The passage discusses the administration of MP (presumably an abbreviation for a different drug) in various ways in an experimental context related to cytotoxic edema induction. The text does not mention asthma or any related symptoms, making it impossible to infer any connection between hydrocortisone administration and asthma based on this information alone. + The two steroids have different potencies and pharmacokinetics that can impact their effectiveness in treating inflammation. Hydrocortisone is often used for short-term anti-inflammatory therapy due to its short half-life (8-12 hours), while methylprednisolone has a longer half-life (1" +15540854,Hydrocortisone prevents pneumonia,474,Forty-eight patients who underwent bone marrow transplantation (BMT) from serologically HLA-matched unrelated donors received tacrolimus (FK506) alone or with methotrexate (MTX) and/or methylprednisolone (mPSL) to prevent graft-versus-host disease (GVHD).,False,"'Does the phrase ""Hydrocortisone prevents pneumonia"" receive at least indirect support from the statement: ""Forty-eight patients who underwent bone marrow transplantation (BMT) from serologically HLA-matched unrelated donors received tacrolimus (FK506) alone or with methotrexate (MTX) and/or methylprednisolone (mPSL) to prevent graft-versus-host disease (GVHD).""?","No, the statement does not provide direct or indirect support for the phrase ""Hydrocortisone prevents pneumonia."" The statement discusses the use of immunosuppressive drugs (tacrolimus, methotrexate, methylprednisolone) in bone marrow transplantation patients to prevent graft-versus-host disease but does not mention hydrocortisone nor pneumonia prevention." +14020540,Hydrocortisone prevents bronchopulmonary dysplasia,475,"Thus, calpeptin and methylprednisolone are found to be neuroprotective in SCI.",False,"'Does the phrase ""Hydrocortisone prevents bronchopulmonary dysplasia"" receive at least indirect support from the statement: ""Thus, calpeptin and methylprednisolone are found to be neuroprotective in SCI.""?","No, the statement ""Thus, calpeptin and methylprednisolone are found to be neuroprotective in SCI"" does not provide indirect support for the phrase ""Hydrocortisone prevents bronchopulmonary dysplasia."" - - To provide further context, hydrocortisone is a type of corticosteroid often used in treating various medical conditions due to its potent anti-inflammatory effects. While some studies suggest that corticosteroids like hydrocortisone can benefit asthma patients by reducing inflammation in their airways, it would require separate evidence specifically linking hydrocortisone administration to improvements in asthma symptoms for the claim ""Hydrocortisone affects asthma"" to be supported. + The reason is that these two statements refer to different medical conditions and substances. Bronchopulmonary dysplasia is a lung condition primarily affecting premature infants, while SCI refers to spinal cord injuries in humans. Calpeptin and methylprednisolone are substances being studied for their neuroprotective effects in spinal cord injuries, whereas hydrocortisone is a steroid hormone used primarily for its anti-inflammatory effects in various conditions such as asthma, allergies, arthritis, and adrenal insufficiency. - - In conclusion, while hydrocortisone has been studied in relation to asthma treatment, the provided" -8017440,Hydrocortisone affects obesity disorder,437,"On the other hand, daily administration of methylprednisolone and tenoxicam for 4 weeks caused increased inflammation and fibrosis and wasn't affective on protection of nerve physiomorphology.",False,"Is the triple 'Hydrocortisone affects obesity disorder' supported by the sentence: 'On the other hand, daily administration of methylprednisolone and tenoxicam for 4 weeks caused increased inflammation and fibrosis and wasn't affective on protection of nerve physiomorphology.'?","No, the statement does not provide indirect support for the phrase ""Hydrocortisone affects obesity disorder."" The statement discusses the effects of methylprednisolone and tenoxicam on inflammation and nerve physiomorphology after 4 weeks of daily administration. Hydrocortisone is not mentioned in the statement, nor is there any connection made to obesity disorder. Therefore, it is inappropriate to draw such conclusions based on this information alone. + Although both statements discuss medical interventions (calpeptin, methylprednisolone, and hydrocortisone), they concern different medical conditions (bronchopulmonary dysplasia and spinal cord injuries). As such, no indirect support can be inferred from one statement for the other." +13075196,Hydrocortisone prevents atrial fibrillation,476,"Methylprednisolone prevents the development of autotomy and neuropathic edema in rats, but has no effect on nociceptive thresholds.",False,"'Does the phrase ""Hydrocortisone prevents atrial fibrillation"" receive at least indirect support from the statement: ""Methylprednisolone prevents the development of autotomy and neuropathic edema in rats, but has no effect on nociceptive thresholds.""?","No, the statement does not provide indirect support for the phrase ""Hydrocortisone prevents atrial fibrillation."" - To provide indirect support for the statement ""Hydrocortisone affects obesity disorder,"" one would need evidence suggesting that hydrocortisone has some impact on obesity disorder, either positively (i.e., reducing inflammation associated with obesity) or negatively (i.e., exacerbating inflammation associated with obesity). The provided statement does not contain any information about hydrocortisone that could be used inferentially in relation to obesity disorder. + The statement discusses the effects of Methylprednisolone on rats, particularly in relation to autotomy, neuropathic edema, and nociceptive thresholds. It does not mention Hydrocortisone or atrial fibrillation at all. Therefore, there is no connection that can be drawn between these two statements to indirectly support the claim about Hydrocortisone preventing atrial fibrillation. - It is essential to maintain rigorous standards when interpreting scientific evidence to avoid drawing false conclusions based on incomplete information. This helps ensure that subsequent actions based on these conclusions are well-informed" -7974249,Hydrocortisone affects Insulin resistance,438,Methylprednisolone was temporarily stopped while a broad work up for inflammatory and neoplastic causes was pursued.,False,Is the triple 'Hydrocortisone affects Insulin resistance' supported by the sentence: 'Methylprednisolone was temporarily stopped while a broad work up for inflammatory and neoplastic causes was pursued.'?,"No, the statement does not provide indirect support for the claim that hydrocortisone affects insulin resistance. The statement mentions methylprednisolone, which is a synthetic glucocorticoid similar to hydrocortisone in its therapeutic effects but is not identical in its mechanisms of action or metabolic side effects. Although both drugs can impact glucose metabolism and potentially contribute to insulin resistance indirectly through their anti-inflammatory properties, they have different chemical structures and pharmacological profiles that could lead to distinct effects on insulin sensitivity in vivo. + Furthermore, even if the statement had mentioned Hydrocortisone, it would still not provide indirect support. This is because the two steroids have different effects on biological systems due to their unique chemical structures and mechanisms of action. Therefore, what applies to one may not necessarily apply to the other. - To establish indirect support for the original claim, one should look for evidence that demonstrates similar glucocorticoid-induced metabolic consequences between methylprednisolone and hydrocortisone specifically in relation to insulin resistance. Additionally, it is essential to consider whether methylprednisolone was temporarily stopped due to its metabolic side effects on insulin resistance in particular as opposed to other potential adverse reactions. + In conclusion, without direct experimental evidence demonstrating that Hydrocortisone prevents atrial fibrillation in humans or animals, there is no basis for making such a claim based on the provided statement." +12187318,Hydrocortisone prevents Insulin resistance,477,Chronically impaired renal function and the use of methylprednisolone may be the risk factors for SP.,False,"'Does the phrase ""Hydrocortisone prevents Insulin resistance"" receive at least indirect support from the statement: ""Chronically impaired renal function and the use of methylprednisolone may be the risk factors for SP.""?","No, the statement ""Chronically impaired renal function and the use of methylprednisolone may be the risk factors for SP"" does not provide indirect support for the phrase ""Hydrocortisone prevents Insulin resistance."" - In summary, while both hydrocortisone and methylprednisolone belong to the glucocorticoid class of medications that can" -7366981,Hydrocortisone affects Hypoxemia,439,"Pneumocystis pneumonia induced by this dose of tacrolimus has been reported in many cases; however, we encountered a rare case of Pneumocystis pneumonia induced by low-dose tacrolimus and methylprednisolone.",False,"Is the triple 'Hydrocortisone affects Hypoxemia' supported by the sentence: 'Pneumocystis pneumonia induced by this dose of tacrolimus has been reported in many cases; however, we encountered a rare case of Pneumocystis pneumonia induced by low-dose tacrolimus and methylprednisolone.'?","No, the statement does not provide direct or indirect support for the phrase ""Hydrocortisone affects Hypoxemia"". The statement discusses Pneumocystis pneumonia induced by tacrolimus and methylprednisolone, but it does not mention hydrocortisone or hypoxemia. Hypoxemia refers to low oxygen levels in the blood, while hydrocortisone is a type of corticosteroid often used for its anti-inflammatory effects. The connection between these two concepts is not evident in the provided statement." -7266667,Hydrocortisone affects dissociative amnesia,440,The increased interval in the administration of MP resulted in slightly greater pain and an increased prevalence of NeP.,False,Is the triple 'Hydrocortisone affects dissociative amnesia' supported by the sentence: 'The increased interval in the administration of MP resulted in slightly greater pain and an increased prevalence of NeP.'?,"No, the statement does not provide indirect support for the phrase ""Hydrocortisone affects dissociative amnesia."" The statement discusses the effects of an increased interval in medication administration on pain and neuropathic pain prevalence (NeP). Hydrocortisone is not mentioned in the statement, making it irrelevant in establishing any connection between hydrocortisone use and dissociative amnesia." -27426083,Hydrocortisone produces HIV infectious disease,441,"We describe that high-dose methylprednisolone (20 mg/kg) can induce multifocal osteonecrosis (ON) in conjunction with thrombocytopenia, hypofibrinogenemia, and hyperlipemia.",False,"Is the triple 'Hydrocortisone produces HIV infectious disease' supported by the sentence: 'We describe that high-dose methylprednisolone (20 mg/kg) can induce multifocal osteonecrosis (ON) in conjunction with thrombocytopenia, hypofibrinogenemia, and hyperlipemia.'?","No, the statement does not provide indirect support for the phrase ""Hydrocortisone produces HIV infectious disease."" The statement discusses the side effects of high-dose methylprednisolone (20 mg/kg) treatment, including multifocal osteonecrosis (ON), thrombocytopenia, hypofibrinogenemia, and hyperlipemia. Hydrocortisone is another type of corticosteroid hormone like methylprednisolone, but there is no mention or implication in the statement connecting hydrocortisone to HIV infectious disease." -24427531,Hydrocortisone produces cirrhosis of liver,442,"OBJECTIVE: To report the third published case, as of April 8, 2006, of methylprednisolone-induced toxic hepatitis.",False,"Is the triple 'Hydrocortisone produces cirrhosis of liver' supported by the sentence: 'OBJECTIVE: To report the third published case, as of April 8, 2006, of methylprednisolone-induced toxic hepatitis.'?","No, the statement does not provide indirect support for the phrase ""Hydrocortisone produces cirrhosis of liver."" The objective in question discusses a case of methylprednisolone-induced toxic hepatitis. Methylprednisolone is not hydrocortisone; they are both glucocorticoids but different compounds with distinct pharmacological profiles. Hydrocortisone has not been mentioned or implicated in the statement, so there is no basis for inferring any association between hydrocortisone use and cirrhosis of the liver from this information alone." -23738730,Hydrocortisone produces congenital adrenal hyperplasia,443,"To our knowledge, this is the first discussion considering the possibility that the methylprednisolone recommended by NASCIS may cause acute corticosteroid myopathy.",False,"Is the triple 'Hydrocortisone produces congenital adrenal hyperplasia' supported by the sentence: 'To our knowledge, this is the first discussion considering the possibility that the methylprednisolone recommended by NASCIS may cause acute corticosteroid myopathy.'?","No, the statement does not provide indirect support for the phrase ""Hydrocortisone produces congenital adrenal hyperplasia"". + The statement discusses potential risk factors for ""SP"" (which is not clearly defined in the context provided), one of which is methylprednisolone use. Methylprednisolone is a synthetic glucocorticoid, similar to hydrocortisone, which is also a glucocorticoid used to treat various conditions including adrenal insufficiency. - The statement discusses methylprednisolone, which is a synthetic glucocorticoid used in various medical treatments including spinal cord injuries, as potentially causing acute corticosteroid myopathy. This is unrelated to hydrocortisone, which is a naturally occurring glucocorticoid produced by the adrenal gland, primarily involved in the regulation of metabolism, immune response, and stress response. + However, even though hydrocortisone and methylprednisolone are from the same class of drugs (glucocorticoids), they are not interchangeable in terms of their effects on insulin resistance. Some studies suggest that glucocorticoids can induce insulin resistance, but they do not provide evidence that hydrocortisone prevents it. - Congenital adrenal hyperplasia (CAH) is a group of inherited genetic disorders affecting the adrenal glands and is not directly related to hydrocortisone administration. CAH is most commonly caused by mutations in genes encoding enzymes involved in cortisol synthesis leading to impaired cortisol production and excessive production of other steroid hormones. Hydrocortisone is sometimes used in treating CAH but does not cause it. + Therefore, while the statement provides some context about glucocorticoids and potential risk factors for SP, it does not provide indirect support for the claim that hydroc" +14643692,Hydrocortisone exacerbates Sepsis,478,"Because a common therapy for acute spinal cord injury is the use of an antiinflammatory synthetic glucocorticoid (methylprednisolone), we sought to determine mechanisms contributing to inflammation shortly after acute injury.",False,"'Does the phrase ""Hydrocortisone exacerbates Sepsis"" receive at least indirect support from the statement: ""Because a common therapy for acute spinal cord injury is the use of an antiinflammatory synthetic glucocorticoid (methylprednisolone), we sought to determine mechanisms contributing to inflammation shortly after acute injury.""?","No, the statement does not provide indirect support for the phrase ""Hydrocortisone exacerbates Sepsis."" The statement discusses the use of an anti-inflammatory synthetic glucocorticoid (methylprednisolone) in treating acute spinal cord injury and investigating its mechanisms in inflammation after acute injury. Hydrocortisone is also a glucocorticoid but differs from methylprednisolone in terms of potency and duration of action. Moreover, sepsis is not explicitly mentioned in the statement. Therefore, it is inappropriate to make inferences about hydrocortisone's effects on sepsis based on this information alone." +8122784,Hydrocortisone exacerbates obesity disorder,479,"Combined treatments of rG-CSF with cefotaxime, cefazolin, fosfomycin, gentamicin or amphotericin B were evaluated in systemic infections with Pseudomonas aeruginosa, Escherichia coli, Serratia marcescens, Staphylococcus aureus and Candida albicans in leucopenic mice induced by pretreatment with cyclophosphamide.",False,"'Does the phrase ""Hydrocortisone exacerbates obesity disorder"" receive at least indirect support from the statement: ""Combined treatments of rG-CSF with cefotaxime, cefazolin, fosfomycin, gentamicin or amphotericin B were evaluated in systemic infections with Pseudomonas aeruginosa, Escherichia coli, Serratia marcescens, Staphylococcus aureus and Candida albicans in leucopenic mice induced by pretreatment with cyclophosphamide.""?","No, the statement does not provide indirect support for the phrase ""Hydrocortisone exacerbates obesity disorder"". The statement discusses the evaluation of combined treatments of rG-CSF with various antibiotics and amphotericin B in systemic infections caused by specific bacteria and Candida albicans in leucopenic mice pretreated with cyclophosphamide. There is no mention of hydrocortisone, obesity, or any related disorders in the statement." +25411585,Hydrocortisone predisposes atrial fibrillation,480,"One such marker, CTX-M-15, expressed by Enterobacteriaceae produces beta-lactamases, which hydrolyze the cephalosporin group of antibiotics, such as cefotaxime, used in the treatment of both Gram-positive and negative bacterial infections.",False,"'Does the phrase ""Hydrocortisone predisposes atrial fibrillation"" receive at least indirect support from the statement: ""One such marker, CTX-M-15, expressed by Enterobacteriaceae produces beta-lactamases, which hydrolyze the cephalosporin group of antibiotics, such as cefotaxime, used in the treatment of both Gram-positive and negative bacterial infections.""?","No, the statement does not provide indirect support for the phrase ""Hydrocortisone predisposes atrial fibrillation."" The statement discusses the role of CTX-M-15, an enzyme produced by Enterobacteriaceae that hydrolyzes cephalosporin antibiotics like cefotaxime. This has no direct or indirect connection to hydrocortisone or atrial fibrillation. Atrial fibrillation is a heart condition characterized by irregular heart rhythm, while hydrocortisone is a corticosteroid hormone used in medical treatments for various conditions such as inflammation and allergies. The connection between these two concepts is not established in the provided statement." +19755964,Hydrocortisone predisposes Sepsis,481,"CONS, Staphylococcus aureus, Enterococci, Escherichia coli, Klebsiella and Enterobacter represented 91.9% of LOS episodes and were susceptible to vancomycin and cefotaxime (96.1%), vancomycin and gentamicin (97.0%) and cloxacillin and gentamicin (38.1%).",False,"'Does the phrase ""Hydrocortisone predisposes Sepsis"" receive at least indirect support from the statement: ""CONS, Staphylococcus aureus, Enterococci, Escherichia coli, Klebsiella and Enterobacter represented 91.9% of LOS episodes and were susceptible to vancomycin and cefotaxime (96.1%), vancomycin and gentamicin (97.0%) and cloxacillin and gentamicin (38.1%).""?","No, the statement does not provide indirect support for the phrase ""Hydrocortisone predisposes Sepsis."" The statement discusses antibiotic susceptibility patterns in certain bacterial species that frequently cause hospital-acquired infections (Los episodes). Hydrocortisone is a type of steroid hormone often used in clinical settings for its anti-inflammatory effects; sepsis is a life-threatening condition that can arise from an exaggerated immune response to infection. - Therefore, there is no indirect support for the claim that hydrocortisone produces congenital adrenal" -20514012,"Hydrocortisone produces dermatitis, atopic",444,"However, high-dose steroids like dexamethasone or methylprednisolone had proven their clearcut anti-tumoral action.",False,"Is the triple 'Hydrocortisone produces dermatitis, atopic' supported by the sentence: 'However, high-dose steroids like dexamethasone or methylprednisolone had proven their clearcut anti-tumoral action.'?","No, the statement does not provide indirect support for the phrase ""Hydrocortisone produces dermatitis, atopic."" In fact, it does not mention hydrocortisone at all. The statement discusses high-dose steroids like dexamethasone and methylprednisolone in relation to their anti-tumoral action. Hydrocortisone is structurally and functionally different from dexamethasone and methylprednisolone; it has lower glucocorticoid receptor binding affinity and is less potent than these synthetic steroids. Hydrocortisone is commonly associated with various side effects such as dermatitis; however, it also has anti-inflammatory properties that can be beneficial in certain clinical settings. Nonetheless, no link can be inferred from one statement about high-dose steroids to another statement about hydrocortisone-induced dermatitis based solely on their shared classification as steroids." -18924640,Hydrocortisone produces Inflammation,445,"Methylprednisolone increases some astrogliosis and inflammation biomarkers' levels; however, it did not affect the apoptotic biomarkers.",False,"Is the triple 'Hydrocortisone produces Inflammation' supported by the sentence: 'Methylprednisolone increases some astrogliosis and inflammation biomarkers' levels; however, it did not affect the apoptotic biomarkers.'?","No, the statement does not provide indirect support for the phrase ""Hydrocortisone produces Inflammation."" The statement discusses Methylprednisolone, not Hydrocortisone, and its effects on certain biomarkers related to inflammation and apoptosis (cell death). The lack of effect on apoptotic biomarkers does not imply an increase in inflammation. Furthermore, Hydrocortisone and Methylprednisolone are both glucocorticoids but have different pharmacological profiles, so inferences about one cannot be made based on studies involving the other without additional evidence supporting such a link." -16473285,Hydrocortisone produces type 1 diabetes mellitus,446,Effect of Methylprednisolone on Inflammation and Coagulation in Patients with Severe COVID-19: A Retrospective Cohort Study.,False,Is the triple 'Hydrocortisone produces type 1 diabetes mellitus' supported by the sentence: 'Effect of Methylprednisolone on Inflammation and Coagulation in Patients with Severe COVID-19: A Retrospective Cohort Study.'?,"No, the statement ""Effect of Methylprednisolone on Inflammation and Coagulation in Patients with Severe COVID-19: A Retrospective Cohort Study"" does not provide any direct or indirect support for the claim that ""Hydrocortisone produces type 1 diabetes mellitus."" The study focuses on Methylprednisolone (a glucocorticoid similar to Hydrocortisone) and its effects on inflammation and coagulation in patients with severe COVID-19, not on its potential in inducing type 1 diabetes mellitus. + While it is possible that hydrocortisone use could influence infection susceptibility or severity in some contexts due to its immunosuppressive properties, no information regarding hydrocortisone use is present in the statement provided. Therefore, it is not possible to infer any relationship between hydrocortisone use, susceptibility to infection, or sepsis based on the given information." +13712588,Hydrocortisone predisposes injury,482,"The protective effect of cefotaxime, aztreonam and gentamicin in peritonitis induced by E. coli alone or combined with B. fragilis was evaluated by analysing mortality at 24 and 48 h after bacterial inoculation and treating the animals with two doses of each antibiotic.",False,"'Does the phrase ""Hydrocortisone predisposes injury"" receive at least indirect support from the statement: ""The protective effect of cefotaxime, aztreonam and gentamicin in peritonitis induced by E. coli alone or combined with B. fragilis was evaluated by analysing mortality at 24 and 48 h after bacterial inoculation and treating the animals with two doses of each antibiotic.""?","No, the statement does not provide indirect support for the phrase ""Hydrocortisone predisposes injury."" The statement discusses an experiment involving the administration of antibiotics (cefotaxime, aztreonam, and gentamicin) to treat peritonitis induced by Escherichia coli (E. coli) alone or combined with Bacteroides fragilis. The study examines mortality rates at 24 and 48 hours after bacterial inoculation in animals receiving antibiotic treatment. Hydrocortisone is not mentioned in the statement; therefore, there is no connection between hydrocortisone and potential injury in this context. - The two statements discuss different medical conditions (COVID-19 vs type 1 diabetes mellitus) and different glucocorticoids (Methylprednisolone vs Hydrocortisone). Thus, there is no link between them that would provide any evidence for the claim about Hydrocortisone causing type 1 diabetes mellitus. + To provide indirect support for the phrase ""Hydrocortisone predisposes injury,"" some evidence of hydrocortisone being associated with increased susceptibility to injury would be necessary. This could include studies showing that hydrocortisone use correlates with higher injury rates in animals challenged by bacterial infections or other stressors known to induce injury. As it stands, there is no evidence in the given statement that would lead one to infer any relationship between hydrocortisone and injury." +12555774,Hydrocortisone predisposes toxic shock syndrome,483,"HR 810 had more potent protective effect than ceftazidime (CAZ), cefoperazone (CPZ), and cefotaxime (CTX) on systemic infections induced by Escherichia coli Ec-31, Staphylococcus aureus SMITH, and Serratia marcescens Sm-6 in mice.",False,"'Does the phrase ""Hydrocortisone predisposes toxic shock syndrome"" receive at least indirect support from the statement: ""HR 810 had more potent protective effect than ceftazidime (CAZ), cefoperazone (CPZ), and cefotaxime (CTX) on systemic infections induced by Escherichia coli Ec-31, Staphylococcus aureus SMITH, and Serratia marcescens Sm-6 in mice.""?","No, the statement does not provide indirect support for the phrase ""Hydrocortisone predisposes toxic shock syndrome."" The statement discusses the efficacy of various antibiotics in protecting mice from systemic infections caused by certain bacteria. Hydrocortisone is not mentioned in this statement, nor is there any information about its potential relationship to toxic shock syndrome. Therefore, it is not possible to make any inferences about hydrocortisone's role in toxic shock syndrome based on this statement alone." +11782928,Hydrocortisone predisposes Inflammation,484,"1,480 patients, undergoing elective orthopedic and traumatic surgery, received intragluteal injections of ceftriaxone (Rocephin) to prevent bacterial infections.",False,"'Does the phrase ""Hydrocortisone predisposes Inflammation"" receive at least indirect support from the statement: ""1,480 patients, undergoing elective orthopedic and traumatic surgery, received intragluteal injections of ceftriaxone (Rocephin) to prevent bacterial infections.""?","No, the statement does not provide indirect support for the phrase ""Hydrocortisone predisposes Inflammation."" The statement discusses patients receiving ceftriaxone (Rocephin) injections for preventing bacterial infections during surgery, but it does not mention hydrocortisone or inflammation at all. In order for there to be indirect support for ""Hydrocortisone predisposes Inflammation,"" there should be some connection between hydrocortisone, ceftriaxone (Rocephin), or surgery in terms of their effects on inflammation; however, no such connection is made in the statement provided. - Furthermore, glucocorticoids like Hydrocortisone and Methylprednisolone can have various side-effects depending on factors such" -15760263,Hydrocortisone produces toxic shock syndrome,447,"METHODS/DESIGN: This study is a 12-week, randomised, double-blind, placebo-controlled trial analysing the effects of high-dose intravenous methylprednisolone in very early SSc.",False,"Is the triple 'Hydrocortisone produces toxic shock syndrome' supported by the sentence: 'METHODS/DESIGN: This study is a 12-week, randomised, double-blind, placebo-controlled trial analysing the effects of high-dose intravenous methylprednisolone in very early SSc.'?","No, the statement does not provide any indirect support for the phrase ""Hydrocortisone produces toxic shock syndrome."" The study mentioned in the statement is investigating the effects of high-dose intravenous methylprednisolone in very early systemic sclerosis (SSc), not hydrocortisone. Hydrocortisone, methylprednisolone, and other glucocorticoids can produce side effects such as toxic shock syndrome; however, it is essential to base conclusions on evidence specific to hydrocortisone rather than making inferences based on related compounds." -15330155,Hydrocortisone produces chronic primary adrenal insufficiency,448,"Methods: The potential interferences Se@SiO2 nanocomposites may have to the therapeutic effect of methylprednisolone (MPS) were evaluated by classical therapeutic effect index of acute respiratory distress syndrome (ARDS), such as wet-to-dry weight ratio, inflammatory factors IL-1beta and TNF-alpha.",False,"Is the triple 'Hydrocortisone produces chronic primary adrenal insufficiency' supported by the sentence: 'Methods: The potential interferences Se@SiO2 nanocomposites may have to the therapeutic effect of methylprednisolone (MPS) were evaluated by classical therapeutic effect index of acute respiratory distress syndrome (ARDS), such as wet-to-dry weight ratio, inflammatory factors IL-1beta and TNF-alpha.'?","No, the statement does not provide indirect support for the phrase ""Hydrocortisone produces chronic primary adrenal insufficiency."" The provided statement discusses an experiment where Se@SiO2 nanocomposites were evaluated for their potential interference with methylprednisolone (MPS) therapy in treating acute respiratory distress syndrome (ARDS). The therapeutic effect index was assessed using wet-to-dry weight ratio and inflammatory factors IL-1beta and TNF-alpha. Hydrocortisone is not mentioned in this context; therefore, no link can be established between hydrocortisone use and chronic primary adrenal insufficiency based on this information alone." -14100936,Hydrocortisone produces Insulin resistance,449,Our case likely represents worsening of DON due to soft tissue swelling secondary to OR despite cover with IVMP in a patient previously responsive to IVMP alone.,False,Is the triple 'Hydrocortisone produces Insulin resistance' supported by the sentence: 'Our case likely represents worsening of DON due to soft tissue swelling secondary to OR despite cover with IVMP in a patient previously responsive to IVMP alone.'?,"No, the statement does not provide indirect support for the phrase ""Hydrocortisone produces Insulin resistance."" The statement discusses a case likely representing worsening of DON (a condition known as Dexamethasone-induced Ocular Hypertension) due to soft tissue swelling secondary to OR (Oral Radiation) despite cover with IVMP (Intravenous Methylprednisolone) in a patient previously responsive to IVMP alone. This statement is about Dexamethasone-induced Ocular Hypertension and its worsening due to certain factors; it does not provide any evidence or mention hydrocortisone or insulin resistance. + Justification: - Insulin resistance refers to cells in the body becoming less responsive to insulin (a hormone produced in the pancreas), making it harder for glucose (sugar) in the bloodstream to enter cells and be used for energy. Hydrocortisone is a type of corticosteroid medication used primarily for its anti-inflammatory effects in various conditions such as allergic reactions, asthma, skin conditions, rheumatoid arthritis, and" -13891079,Hydrocortisone produces obesity disorder,450,[Treatment of invasive thymoma with myasthenia gravis: a case report responsive to azathioprine and methylprednisolone].,False,Is the triple 'Hydrocortisone produces obesity disorder' supported by the sentence: '[Treatment of invasive thymoma with myasthenia gravis: a case report responsive to azathioprine and methylprednisolone].'?,"No, the statement does not provide any direct or indirect support for the phrase ""Hydrocortisone produces obesity disorder."" The case report discusses the treatment of invasive thymoma with myasthenia gravis using azathioprine and methylprednisolone; however, it does not mention hydrocortisone as being responsible for producing obesity disorder in patients undergoing treatment. + Hydrocortisone is a type of corticosteroid that is often used as an anti-inflammatory medication due to its ability to reduce inflammation in various conditions like allergies, asthma, arthritis, and autoimmune disorders. In some cases, hydrocortisone may be used perioperatively as an adjunct treatment for controlling inflammation associated with surgical trauma. - The study might have used methylprednisolone as part of its treatment regimen; methylprednisolone is a synthetic glucocorticoid similar to hydrocortisone in its therapeutic effects on inflammation. However, it does not follow that hydrocortisone would produce obesity disorder based on methylprednisolone use in this case report alone. + In contrast, ceftriaxone (" +10520517,Hydrocortisone predisposes obesity disorder,485,Proceedings: A double blind trial of carbenoxolone and geranyl farnesylacetate in gastric ulcer.,False,"'Does the phrase ""Hydrocortisone predisposes obesity disorder"" receive at least indirect support from the statement: ""Proceedings: A double blind trial of carbenoxolone and geranyl farnesylacetate in gastric ulcer.""?","No, there is no direct or indirect support for the phrase ""Hydrocortisone predisposes obesity disorder"" in the statement ""Proceedings: A double blind trial of carbenoxolone and geranyl farnesylacetate in gastric ulcer."" - Obesity is one potential side effect associated with long-term use and high doses of glucocorticoids like hydrocortisone; however, establishing causality between hydrocortisone use and obesity disorder would require further studies specifically designed to assess such an association in detail." -13796050,Hydrocortisone produces adrenal cortex neoplasm,451,High-dose intravenous methylprednisolone is the first-line therapy for acute exacerbations of NMO.,False,Is the triple 'Hydrocortisone produces adrenal cortex neoplasm' supported by the sentence: 'High-dose intravenous methylprednisolone is the first-line therapy for acute exacerbations of NMO.'?,"No, the statement ""High-dose intravenous methylprednisolone is the first-line therapy for acute exacerbations of NMO"" does not provide indirect support for the claim that ""Hydrocortisone produces adrenal cortex neoplasm."" + The statement provided is an announcement of a clinical trial involving two different drugs for treating gastric ulcers. It does not mention hydrocortisone, obesity disorder, nor does it provide any information that could imply hydrocortisone predisposes obesity disorder. - The two statements discuss different aspects of corticosteroid treatment and neuroimmunological conditions. The first statement refers to methylprednisolone as a first-line therapy for Neuromyelitis Optica (NMO) exacerbations without mentioning hydrocortisone or adrenal cortex neoplasm (cancer). + Hydrocortisone is a type of corticosteroid medication that is used to treat various conditions such as allergies, skin conditions, ulcerative colitis, arthritis, lupus, multiple sclerosis, and bronchopulmonary aspergillosis. It is not typically associated with causing obesity disorder as a side effect in a direct manner. However, it can influence appetite, metabolism, and fluid retention which might indirectly contribute to weight gain in some individuals if used over extended periods. Still, this information is not suggested nor supported by the provided" +8615556,Hydrocortisone predisposes dissociative amnesia,486,A controlled double-blind study was performed in 17 institutes using gefarnate as a control drug in order to investigate the therapeutic effect and safety of pirenzepine dihydrochloride (LS 519) in duodenal ulcer.,False,"'Does the phrase ""Hydrocortisone predisposes dissociative amnesia"" receive at least indirect support from the statement: ""A controlled double-blind study was performed in 17 institutes using gefarnate as a control drug in order to investigate the therapeutic effect and safety of pirenzepine dihydrochloride (LS 519) in duodenal ulcer.""?","No, the statement does not provide indirect support for the phrase ""Hydrocortisone predisposes dissociative amnesia."" The study mentioned investigates the therapeutic effect and safety of pirenzepine dihydrochloride (LS 519) in duodenal ulcer using gefarnate as a control drug. There is no mention of hydrocortisone or dissociative amnesia in the statement. Therefore, it does not offer any relevant information or evidence to support the claim about hydrocortisone predisposing dissociative amnesia." +8552834,Hydrocortisone predisposes asthma,487,Gefarnate at 300 mg/kg (p.o.) significantly inhibited phenylbutazone-induced gastric ulcers in rats but had no effect on other ulcer models.,False,"'Does the phrase ""Hydrocortisone predisposes asthma"" receive at least indirect support from the statement: ""Gefarnate at 300 mg/kg (p.o.) significantly inhibited phenylbutazone-induced gastric ulcers in rats but had no effect on other ulcer models.""?","No, the statement does not provide any indirect support for the phrase ""Hydrocortisone predisposes asthma."" The statement discusses the effects of Gefarnate on phenylbutazone-induced gastric ulcers in rats, which is unrelated to Hydrocortisone or asthma. Hydrocortisone is a steroid hormone often used in treating asthma due to its anti-inflammatory properties; however, it does not imply that Hydrocortisone predisposes asthma." +8002300,Hydrocortisone predisposes Insulin resistance,488,We tested streptomycin (ST) and neomycin (NEO) as analgesic agents applied in situ in rat paw inflammation caused by formalin or carrageenan administration.,False,"'Does the phrase ""Hydrocortisone predisposes Insulin resistance"" receive at least indirect support from the statement: ""We tested streptomycin (ST) and neomycin (NEO) as analgesic agents applied in situ in rat paw inflammation caused by formalin or carrageenan administration.""?","No, the statement does not provide indirect support for the phrase ""Hydrocortisone predisposes Insulin resistance."" The experiment mentioned in the statement tests streptomycin (ST) and neomycin (NEO) as analgesic agents in rat paw inflammation caused by formalin or carrageenan administration. There is no mention of hydrocortisone, insulin resistance, or any related conditions in this experiment. Therefore, it does not offer any relevant information to evaluate the claim about hydrocortisone predisposing insulin resistance." +7960726,Hydrocortisone predisposes pneumonia,489,[ON THE ACTION OF A NEOMYCIN AND THIOPENICOL PREPARATION IN EXPERIMENTAL BURNS].,False,"'Does the phrase ""Hydrocortisone predisposes pneumonia"" receive at least indirect support from the statement: ""[ON THE ACTION OF A NEOMYCIN AND THIOPENICOL PREPARATION IN EXPERIMENTAL BURNS].""?","No, the statement ""Hydrocortisone predisposes pneumonia"" does not receive indirect support from the provided statement about an experiment involving neomycin and thiophenicol in treating experimental burns. The two statements are unrelated as they discuss different substances (hydrocortisone vs neomycin and thiophenicol) and different medical conditions (pneumonia vs burns). To establish indirect support, there should be some connection between hydrocortisone use and pneumonia risk; however, no such connection can be inferred from the given context." +27228384,Methylprednisolone related to Crohn disease,490,"Therefore, we investigated the effect of long-term exposure of an antibiotic cocktail composed of Vancomycin, Neomycin, and Streptomycin, on tumor development and progression in the ApcMin/+ mouse, an established genetic model for familial adenomatous polyposis.",False,"'Does the phrase ""Methylprednisolone related to Crohn disease"" receive at least indirect support from the statement: ""Therefore, we investigated the effect of long-term exposure of an antibiotic cocktail composed of Vancomycin, Neomycin, and Streptomycin, on tumor development and progression in the ApcMin/+ mouse, an established genetic model for familial adenomatous polyposis.""?","No, the statement does not provide indirect support for the phrase ""Methylprednisolone related to Crohn disease."" The statement discusses an investigation into the effect of long-term exposure of an antibiotic cocktail on tumor development and progression in a specific mouse model for familial adenomatous polyposis. Methylprednisolone is a corticosteroid commonly used to treat inflammatory conditions such as Crohn disease; however, it is not mentioned nor implied in the provided statement. Therefore, it is not possible to infer any connection between Methylprednisolone and Crohn disease based on this information alone." +26974005,Methylprednisolone related to hematopoietic and lymphoid system neoplasm,491,Ultrahigh doses of gentamicin and clinically relevant doses of neomycin affect inflammation and angiogenesis in in vivo and in vitro models.,False,"'Does the phrase ""Methylprednisolone related to hematopoietic and lymphoid system neoplasm"" receive at least indirect support from the statement: ""Ultrahigh doses of gentamicin and clinically relevant doses of neomycin affect inflammation and angiogenesis in in vivo and in vitro models.""?","No, the statement does not provide indirect support for the phrase ""Methylprednisolone related to hematopoietic and lymphoid system neoplasm."" The statement discusses the effects of ultrahigh doses of gentamicin and clinically relevant doses of neomycin on inflammation and angiogenesis in in vivo and in vitro models. Methylprednisolone is a corticosteroid used for its anti-inflammatory effects and is not mentioned in the statement. Furthermore, hematopoietic and lymphoid system neoplasms refer to cancers of the blood cells and lymphatic system, respectively, which is not addressed in the statement." +26513818,Methylprednisolone related to B-cell chronic lymphocytic leukemia,492,"Biodegradable polyaspartamide (PASPAM) was grafted with several functional groups to implement diverse roles-octadecylamine (C 18 ) for nano-aggregate formation, dopamine (DOPA) for adhesive function, neomycin (NEO) for inhibition of bacterial infection.",False,"'Does the phrase ""Methylprednisolone related to B-cell chronic lymphocytic leukemia"" receive at least indirect support from the statement: ""Biodegradable polyaspartamide (PASPAM) was grafted with several functional groups to implement diverse roles-octadecylamine (C 18 ) for nano-aggregate formation, dopamine (DOPA) for adhesive function, neomycin (NEO) for inhibition of bacterial infection.""?","No, there is no indirect support for the phrase ""Methylprednisolone related to B-cell chronic lymphocytic leukemia"" in the statement provided. The statement discusses the grafting of functional groups onto biodegradable polyaspartamide (PASPAM) for various roles, but it does not mention or imply any connection to methylprednisolone or B-cell chronic lymphocytic leukemia. Methylprednisolone is a corticosteroid often used to treat inflammation and allergies, while B-cell chronic lymphocytic leukemia is a type of cancer affecting white blood cells. The two subjects are unrelated in the context of the given statement." +26050805,Methylprednisolone related to ankylosing spondylitis,493,Kaposi's sarcoma-associated herpesvirus-positive primary effusion lymphoma tumor formation in NOD/SCID mice is inhibited by neomycin and neamine blocking angiogenin's nuclear translocation.,False,"'Does the phrase ""Methylprednisolone related to ankylosing spondylitis"" receive at least indirect support from the statement: ""Kaposi's sarcoma-associated herpesvirus-positive primary effusion lymphoma tumor formation in NOD/SCID mice is inhibited by neomycin and neamine blocking angiogenin's nuclear translocation.""?","No, there is no direct or indirect support for the phrase ""Methylprednisolone related to ankylosing spondylitis"" in the statement provided. The statement discusses Kaposi's sarcoma-associated herpesvirus-positive primary effusion lymphoma tumor formation in NOD/SCID mice being inhibited by neomycin and neamine blocking angiogenin's nuclear translocation. There is no mention of Methylprednisolone or ankylosing spondylitis in the statement. Methylprednisolone is a corticosteroid used for its anti-inflammatory effects in various conditions including ankylosing spondylitis, but the statement does not provide any information about it." +25845844,Methylprednisolone related to breast neoplasm,494,Neomycin and the combination of neomycin and bacitracin in the prevention of bacterial infection in surgery of the colon and/or rectum.,False,"'Does the phrase ""Methylprednisolone related to breast neoplasm"" receive at least indirect support from the statement: ""Neomycin and the combination of neomycin and bacitracin in the prevention of bacterial infection in surgery of the colon and/or rectum.""?","No, there is no direct or indirect support for the phrase ""Methylprednisolone related to breast neoplasm"" in the statement ""Neomycin and the combination of neomycin and bacitracin in the prevention of bacterial infection in surgery of the colon and/or rectum."" - Hydrocortisone is another type of corticosteroid used in various medical treatments, while methylprednisolone is primarily used for its immunosuppressive effects. The development of adrenal cortex neoplasm due to hydrocortisone use is not mentioned as a potential side effect in either statement. + The statement primarily discusses the use of neomycin, alone or in combination with bacitracin, for preventing bacterial infections during colon or rectum surgery. It does not mention methylprednisolone nor breast neoplasm (a medical term for breast cancer). Therefore, it does not provide any basis for connecting methylprednisolone to breast neoplasm." +25642837,Methylprednisolone related to dermatomyositis,495,Results of salvage therapy with mini-hyper-CVD and inotuzumab ozogamicin with or without blinatumomab in pre-B acute lymphoblastic leukemia.,False,"'Does the phrase ""Methylprednisolone related to dermatomyositis"" receive at least indirect support from the statement: ""Results of salvage therapy with mini-hyper-CVD and inotuzumab ozogamicin with or without blinatumomab in pre-B acute lymphoblastic leukemia.""?","No, the statement does not provide indirect support for the phrase ""Methylprednisolone related to dermatomyositis."" The statement discusses salvage therapy for pre-B acute lymphoblastic leukemia using mini-hyper-CVD, inotuzumab ozogamicin, and potentially blinatumomab. Dermatomyositis is an inflammatory disease that affects muscle strength and skin; it is not mentioned in the statement nor is it related through any implied context. Methylprednisolone is a corticosteroid used in various treatments including dermatomyositis but it is not mentioned in the statement either. Therefore, there is no indirect support for the connection between Methylprednisolone and dermatomyositis in this statement." +25328503,Methylprednisolone related to Meniere disease,496,"The impressive clinical success of the continuously intravenously infused T cell-redirecting bispecific antibody (T-bsAb) blinatumomab (anti-CD19 x anti-CD3), and of engineered T cells expressing anti-CD19 chimeric antigen receptors (CAR-T cells) in hematological malignancies, has led to renewed interest in a novel cancer immunotherapy strategy that combines features of antibody- and cell-based therapies.",False,"'Does the phrase ""Methylprednisolone related to Meniere disease"" receive at least indirect support from the statement: ""The impressive clinical success of the continuously intravenously infused T cell-redirecting bispecific antibody (T-bsAb) blinatumomab (anti-CD19 x anti-CD3), and of engineered T cells expressing anti-CD19 chimeric antigen receptors (CAR-T cells) in hematological malignancies, has led to renewed interest in a novel cancer immunotherapy strategy that combines features of antibody- and cell-based therapies.""?","No, the statement does not provide indirect support for the phrase ""Methylprednisolone related to Meniere disease."" The statement discusses advancements in cancer immunotherapy strategies using T cell-redirecting bispecific antibodies (T-bsAb) and chimeric antigen receptor T cells (CAR-T cells) in hematological malignancies. There is no mention of Methylprednisolone nor Meniere disease in the statement, making it unrelated to the claim in question." +24759961,Methylprednisolone related to non-Hodgkin lymphoma,497,Blinatumomab and inotuzumab ozogamycin represent promising alternatives to conventional chemotherapy in acute lymphoblastic leukaemia (ALL).,False,"'Does the phrase ""Methylprednisolone related to non-Hodgkin lymphoma"" receive at least indirect support from the statement: ""Blinatumomab and inotuzumab ozogamycin represent promising alternatives to conventional chemotherapy in acute lymphoblastic leukaemia (ALL).""?","No, the statement does not provide indirect support for the phrase ""Methylprednisolone related to non-Hodgkin lymphoma."" The statement discusses Blinatumomab and Inotuzumab Ozogamycin as alternatives to conventional chemotherapy in acute lymphoblastic leukaemia (ALL). Methylprednisolone is not mentioned in the statement, nor is there any connection made between it and non-Hodgkin lymphoma. Therefore, there is no indirect support for the phrase in question based on the provided statement." +24691450,Methylprednisolone related to plantar fasciitis,498,Efficacy of ciprofloxacin and dexamethasone in experimental pseudomonas endophthalmitis.,False,"'Does the phrase ""Methylprednisolone related to plantar fasciitis"" receive at least indirect support from the statement: ""Efficacy of ciprofloxacin and dexamethasone in experimental pseudomonas endophthalmitis.""?","No, the statement ""Efficacy of ciprofloxacin and dexamethasone in experimental pseudomonas endophthalmitis"" does not provide indirect support for the phrase ""Methylprednisolone related to plantar fasciitis."" This is because there is no mention of methylprednisolone in the statement, nor is there any reference made to plantar fasciitis. The two drugs mentioned in the statement (ciprofloxacin and dexamethasone) have no direct connection to methylprednisolone in terms of their therapeutic use or pharmacological properties. Dexamethasone is a corticosteroid like methylprednisolone but their effects on plantar fasciitis cannot be inferred from the statement provided as it relates to endophthalmitis treatment in an experimental setting." +24586108,Methylprednisolone related to alcoholic hepatitis,499,CONCLUSIONS: Combination therapy of adalimumab and ciprofloxacin is more effective than adalimumab monotherapy to achieve fistula closure in CD.,False,"'Does the phrase ""Methylprednisolone related to alcoholic hepatitis"" receive at least indirect support from the statement: ""CONCLUSIONS: Combination therapy of adalimumab and ciprofloxacin is more effective than adalimumab monotherapy to achieve fistula closure in CD.""?","No, the statement does not provide any indirect support for the phrase ""Methylprednisolone related to alcoholic hepatitis."" The conclusion in the statement is about the effectiveness of combination therapy (adalimumab and ciprofloxacin) versus adalimumab monotherapy in achieving fistula closure in Crohn's disease (CD). This has no relation to Methylprednisolone or alcoholic hepatitis." +24559507,Methylprednisolone related to respiratory system disorder,500,"Tested substances displayed inhibitory effect towards E. coli DNA gyrase, though less than ciprofloxacin.",False,"'Does the phrase ""Methylprednisolone related to respiratory system disorder"" receive at least indirect support from the statement: ""Tested substances displayed inhibitory effect towards E. coli DNA gyrase, though less than ciprofloxacin.""?","No, the statement ""Tested substances displayed inhibitory effect towards E. coli DNA gyrase, though less than ciprofloxacin"" does not provide indirect support for the phrase ""Methylprednisolone related to respiratory system disorder"". - Moreover, even if there were an association between hydrocortisone use and adrenal cortex neoplasm, it would not necessarily imply that hydrocortisone produces such neoplasms" -13783969,Hydrocortisone produces adrenocortical insufficiency,452,"CONCLUSION: Although the delayed administration of high-dose MP did not significantly increase the severity of pain or prevalence of NeP, it should still be avoided due to the increased risk of serious side effects.",False,"Is the triple 'Hydrocortisone produces adrenocortical insufficiency' supported by the sentence: 'CONCLUSION: Although the delayed administration of high-dose MP did not significantly increase the severity of pain or prevalence of NeP, it should still be avoided due to the increased risk of serious side effects.'?","No, the statement does not provide indirect support for the phrase ""Hydrocortisone produces adrenocortical insufficiency."" The conclusion is about administering high-dose methylprednisolone (MP), not hydrocortisone, and it mentions potential side effects without specifying which ones. Adrenocortical insufficiency is not mentioned in either statement; therefore, there is no connection between them that would allow for indirect support. + The statement is about substances inhibiting E. coli DNA gyrase, an enzyme involved in DNA replication in bacteria like Escherichia coli. Methylprednisolone is a corticosteroid often used for its anti-inflammatory effects in various medical conditions but it is not typically associated with bacterial DNA gyrase inhibition. - The two statements refer to two different medications: hydrocortisone and methylprednisolone (MP). The conclusion is about MP, which is part of a class of drugs known as glucocorticoids that can have various side effects when used in high doses for extended periods. Adrenocortical insufficiency is not explicitly mentioned as one of these side effects in either statement; therefore, it cannot be inferred that hydrocortisone would produce adrenocortical insufficiency based on these statements alone. + Furthermore, respiratory system disorders can be caused by numerous factors including infections, allergies, autoimmune diseases, environmental factors, etc., none of which are directly addressed in the provided statement. Therefore, there is no implicit connection between methylprednisolone, E. coli DNA gyrase inhibition, and respiratory system disorders based on this information alone." +23573980,Methylprednisolone related to pneumonia,1,Evaluation of granulated fenbendazole (22.2%) against induced and naturally occurring helminth infections in cats.,False,"'Does the phrase ""Methylprednisolone related to pneumonia"" receive at least indirect support from the statement: ""Evaluation of granulated fenbendazole (22.2%) against induced and naturally occurring helminth infections in cats.""?","No, the statement ""Evaluation of granulated fenbendazole (22.2%) against induced and naturally occurring helminth infections in cats"" does not provide indirect support for the phrase ""Methylprednisolone related to pneumonia."" The statement discusses an evaluation of fenbendazole, an anthelmintic drug used for treating parasitic worm infections in animals, in cats with helminth infections. Methylprednisolone is a corticosteroid used primarily for its anti-inflammatory effects and is unrelated to fenbendazole or helminth infections in cats. - Additionally, it is essential to consider that any conclusions drawn from these statements should be supported by empirical evidence from well-designed studies that specifically investigate adrenocortical insufficiency as" -13669597,Hydrocortisone produces asthma,453,Methylprednisolone has been used in other Th1 mediated diseases such as rheumatoid arthritis in an attempt to switch off the immune response and so we investigated the efficacy of three days of high dose (1 g) intravenous methylprednisolone at the start of prednisolone therapy in leprosy Type 1 reactions and nerve function impairment.,False,Is the triple 'Hydrocortisone produces asthma' supported by the sentence: 'Methylprednisolone has been used in other Th1 mediated diseases such as rheumatoid arthritis in an attempt to switch off the immune response and so we investigated the efficacy of three days of high dose (1 g) intravenous methylprednisolone at the start of prednisolone therapy in leprosy Type 1 reactions and nerve function impairment.'?,"No, the statement does not provide any indirect support for the phrase ""Hydrocortisone produces asthma."" The statement discusses the use of methylprednisolone in rheumatoid arthritis and leprosy Type 1 reactions, but it does not mention hydrocortisone or asthma at all. Hydrocortisone and methylprednisolone are both corticosteroids used in treating various conditions, but they are not interchangeable in this context, and the effects of one cannot be inferred from the effects of the other. Furthermore, even if the statement had mentioned hydrocortisone, it would still not support the claim that hydrocortisone produces asthma, as it would be necessary to demonstrate a causal relationship between hydrocortisone use and asthma development for such support." -12147996,Hydrocortisone produces Sepsis,454,Myelitis in these patients was not related to graft versus host disease or immune reconstitution and was responsive to intravenous methylprednisolone and cyclophosphamide.,False,Is the triple 'Hydrocortisone produces Sepsis' supported by the sentence: 'Myelitis in these patients was not related to graft versus host disease or immune reconstitution and was responsive to intravenous methylprednisolone and cyclophosphamide.'?,"No, the statement does not provide any direct or indirect support for the phrase ""Hydrocortisone produces Sepsis."" In fact, it seems to suggest the opposite. The statement indicates that intravenous methylprednisolone, which is a type of corticosteroid similar to hydrocortisone, was used to treat myelitis in patients, implying that it was helpful in managing the condition rather than causing sepsis. Sepsis is a systemic inflammatory response to an infection, not typically a result of corticosteroid administration. However, it is important to note that corticosteroids can suppress the immune system, making individuals more susceptible to infections, which could potentially lead to sepsis in certain circumstances. But based on the information provided in the statement, there is no evidence to suggest that hydrocortisone produces sepsis." -11989948,Hydrocortisone produces Hypoxemia,455,"We investigated the effects of YM264, WEB2086, methylprednisolone and ticlopidine on puromycin-induced nephropathy in the rat.",False,"Is the triple 'Hydrocortisone produces Hypoxemia' supported by the sentence: 'We investigated the effects of YM264, WEB2086, methylprednisolone and ticlopidine on puromycin-induced nephropathy in the rat.'?","No, the statement does not provide any direct or indirect support for the claim that hydrocortisone produces hypoxemia (a condition characterized by low oxygen levels in the blood). The study investigates the effects of various compounds on puromycin-induced nephropathy in rats, which is an entirely different biological system and outcome than what would be expected in hydrocortisone-induced hypoxemia. + While it is possible for corticosteroids like methylprednisolone to be associated with an increased risk of pneumonia due to their immunosuppressive effects, the current statement does not provide any information about methylprednisolone, pneumonia, or any related factors that would establish such a connection. Therefore, there is no indirect support for the relationship between methylprednisolone and pneumonia in this context." +23514846,Methylprednisolone related to carpal tunnel syndrome,2,Fenbendazole resistance in O. ostertagi was confirmed with a total treatment failure in reducing worm burden: efficacy of 0%.,False,"'Does the phrase ""Methylprednisolone related to carpal tunnel syndrome"" receive at least indirect support from the statement: ""Fenbendazole resistance in O. ostertagi was confirmed with a total treatment failure in reducing worm burden: efficacy of 0%.""?","No, the statement ""Fenbendazole resistance in O. ostertagi was confirmed with a total treatment failure in reducing worm burden: efficacy of 0%."" does not provide indirect support for the phrase ""Methylprednisolone related to carpal tunnel syndrome."" - - In order for this statement to provide indirect support for the claim, there would need to be some connection between the substances being investigated in the study (YM264, WEB2086, methylprednisolone, ticlopidine) and hydrocortisone-induced hypoxemia. Since no such connection is apparent in either the study design or outcomes reported in the statement provided, it is not reasonable to infer any support for that claim based on this evidence alone. + The statement discusses Fenbendazole resistance in O. ostertagi, which is an issue related to veterinary parasitology, specifically gastrointestinal nematodes in cattle. Methylprednisolone is a corticosteroid used primarily in human medicine for its anti-inflammatory effects in various conditions such as allergies, arthritis, asthma, and autoimmune diseases. Carpal tunnel syndrome is a peripheral entrapment neuropathy characterized by pressure on the median nerve at the wrist, leading to numbness, tingling, weakness, or muscle atrophy in the hand and fingers. - - However, it is important to note that further investigation into potential links between these substances may reveal common mechanisms that could eventually be implicated in hypoxemia development; but based on the information provided in the question alone, no" -11730055,Hydrocortisone produces pneumonia,456,"The study strongly suggests that methylprednisolone has significant beneficial effects in human spinal cord injury, that these effects occur only when the drug is given within 8 hr, and that it helps even in patients with severe spinal cord injuries.",False,"Is the triple 'Hydrocortisone produces pneumonia' supported by the sentence: 'The study strongly suggests that methylprednisolone has significant beneficial effects in human spinal cord injury, that these effects occur only when the drug is given within 8 hr, and that it helps even in patients with severe spinal cord injuries.'?","No, the statement does not provide indirect support for the phrase ""Hydrocortisone produces pneumonia."" The study referenced in the statement investigates the effects of methylprednisolone on human spinal cord injury, not hydrocortisone. The two compounds have different chemical structures and pharmacological properties, meaning that any effects observed in one study may not be applicable or transferable to another compound without further investigation. + While both Methylprednisolone and carpal tunnel syndrome involve human medicine, there is no connection between Fenbendazole resistance in O. ostertagi and Methylprednisolone usage related to carpal" +23364897,Methylprednisolone related to West syndrome,3,Symptoms of perianal itching and visualization of visible motile worms persisted for 6 months despite being treated with multiple courses of albendazole causing a lot of frustration and distress to the caregivers.,False,"'Does the phrase ""Methylprednisolone related to West syndrome"" receive at least indirect support from the statement: ""Symptoms of perianal itching and visualization of visible motile worms persisted for 6 months despite being treated with multiple courses of albendazole causing a lot of frustration and distress to the caregivers.""?","No, the statement does not provide direct or indirect support for the phrase ""Methylprednisolone related to West syndrome."" The statement discusses a patient's experience with perianal itching and visible motile worms that persisted for 6 months despite multiple courses of albendazole treatment. West syndrome is an epileptic disorder characterized by infantile spasms, developmental delay, and a specific EEG pattern called hypsarrhythmia. Methylprednisolone is sometimes used as a treatment for West syndrome, but there is no mention of West syndrome or epileptic symptoms in the provided statement. Therefore, it does not support the connection between Methylprednisolone and West syndrome." +22495910,Methylprednisolone related to myocarditis,4,"Ovicidal effects of albendazole in human ascariasis, ancylostomiasis and trichuriasis.",False,"'Does the phrase ""Methylprednisolone related to myocarditis"" receive at least indirect support from the statement: ""Ovicidal effects of albendazole in human ascariasis, ancylostomiasis and trichuriasis.""?","No, the statement ""Ovicidal effects of albendazole in human ascariasis, ancylostomiasis and trichuriasis"" does not provide indirect support for the phrase ""Methylprednisolone related to myocarditis"". - Additionally, the statement highlights beneficial effects associated with methylprednisolone administration in spinal cord injury cases when given within 8 hours post-injury. This does not suggest any potential adverse effects related to methylprednisolone use, nor does it mention hydrocortisone at all. + The statement is about the ovicidal effects of albendazole, a medication used to treat certain types of intestinal worm infections in humans. This has no direct or indirect relation to methylprednisolone, which is a corticosteroid used to suppress inflammation in various conditions such as allergic reactions, arthritis, asthma, and autoimmune diseases. Myocarditis, an inflammation of the heart muscle, is not known to be directly related to methylprednisolone use. Therefore, there is no connection between the two statements." +22175056,Methylprednisolone related to myopathy,5,"A combination of drugs Ivermectin, Diethylcarbamazine citrate and Albendazole is recommended by WHO to accelerate the Global Programme to Eliminate Lymphatic Filariasis (GPELF).",False,"'Does the phrase ""Methylprednisolone related to myopathy"" receive at least indirect support from the statement: ""A combination of drugs Ivermectin, Diethylcarbamazine citrate and Albendazole is recommended by WHO to accelerate the Global Programme to Eliminate Lymphatic Filariasis (GPELF).""?","No, the statement does not provide indirect support for the phrase ""Methylprednisolone related to myopathy"". The two statements discuss different topics - one is about a combination of drugs recommended by WHO for eliminating lymphatic filariasis (Ivermectin, Diethylcarbamazine citrate and Albendazole), while the other mentions Methylprednisolone which is a corticosteroid used to treat various conditions such as inflammation and allergies but is not part of the recommended combination by WHO for eliminating lymphatic filariasis. Myopathy can be a side effect of long-term use of corticosteroids like Methylprednisolone but it is not explicitly mentioned in the provided statement. Hence, there is no indirect support for ""Methylprednisolone related to myopathy""." +20879022,Methylprednisolone related to Pain,6,Effect of albendazole in experimental toxocariasis of mice.,False,"'Does the phrase ""Methylprednisolone related to Pain"" receive at least indirect support from the statement: ""Effect of albendazole in experimental toxocariasis of mice.""?","No, the statement ""Effect of albendazole in experimental toxocariasis of mice"" does not provide indirect support for the phrase ""Methylprednisolone related to Pain"". - To establish any potential link between hydrocortisone use and pneumonia development, additional evidence would need to be provided that specifically investigates hydrocortisone's impact on respiratory health outcomes." -8328567,Hydrocortisone produces prostate cancer,457,"Comparison of the effects of 2 doses of methylprednisolone on pain, swelling, and trismus after third molar surgery.",False,"Is the triple 'Hydrocortisone produces prostate cancer' supported by the sentence: 'Comparison of the effects of 2 doses of methylprednisolone on pain, swelling, and trismus after third molar surgery.'?","No, the statement does not provide any direct or indirect support for the phrase ""Hydrocortisone produces prostate cancer."" The study mentioned in the statement is focused on comparing two doses of methylprednisolone (a glucocorticoid) on pain, swelling, and trismus after third molar surgery. Hydrocortisone is another type of glucocorticoid but is not mentioned or studied in this context; therefore, no conclusions can be drawn about its effects on prostate cancer from this statement." -8077250,Hydrocortisone produces neoplasm,458,Steatohepatitis during methylprednisolone therapy for ulcerative colitis exacerbation.,False,Is the triple 'Hydrocortisone produces neoplasm' supported by the sentence: 'Steatohepatitis during methylprednisolone therapy for ulcerative colitis exacerbation.'?,"No, the statement ""Steatohepatitis during methylprednisolone therapy for ulcerative colitis exacerbation"" does not provide indirect support for the claim that ""Hydrocortisone produces neoplasm."" + The statement is about an experimental study in mice infected with Toxocara canis (a roundworm) and the effects of albendazole, an antihelmintic drug used to treat parasitic worm infections. It does not mention methylprednisolone, which is a corticosteroid used to suppress inflammation and immune response, nor does it discuss pain. Therefore, there is no logical connection or supportive evidence between these two phrases." +20342058,Methylprednisolone related to chronic progressive multiple sclerosis,7,"Given the low helminth prevalence in our children, the effect of albendazole on malaria is likely to be direct.",False,"'Does the phrase ""Methylprednisolone related to chronic progressive multiple sclerosis"" receive at least indirect support from the statement: ""Given the low helminth prevalence in our children, the effect of albendazole on malaria is likely to be direct.""?","No, there is no direct or indirect support for the phrase ""Methylprednisolone related to chronic progressive multiple sclerosis"" in the statement ""Given the low helminth prevalence in our children, the effect of albendazole on malaria is likely to be direct."" - - The reason is that methylprednisolone is not hydrocortisone. Although both are corticosteroids used in treating various medical conditions (including ulcerative colitis), they have different chemical structures and properties that may lead to distinct side effects. + The statement provided discusses the relationship between helminth prevalence in children and the direct effect of albendazole on malaria. Methylprednisolone is an unrelated corticosteroid medication commonly used for its anti-inflammatory effects in various diseases such as asthma, rheumatoid arthritis, and multiple sclerosis (MS) flares. - - Furthermore, while long-term use of corticosteroids has been associated with an increased risk for developing certain types of neoplasms (cancer), it is crucial to consider that correlation does not imply causation. Other factors may contribute to the development of neoplasms in patients undergoing corticosteroid therapy, such as genetic predisposition, lifestyle factors (e.g., smoking), or concomitant medication use. + The connection between methylprednisolone and chronic progressive multiple sclerosis is not addressed in any way in the provided statement; therefore, it does not offer any indirect support for such a claim. In addition, chronic progressive multiple sclerosis is not typically treated with methylprednisolone since it is more of an acute intervention for MS relapses rather than a treatment for chronic progressive forms of MS. - - Therefore, based on the provided statement alone, there is no solid ground for inferring that hydrocortisone specifically causes neoplasms. Nonetheless, it is essential to emphasize that long-term use" -27711985,Hydrocortisone disrupts adrenocortical insufficiency,459,These results suggest that increasing the uric acid concentration may represent one of the possible mechanisms of action of methylprednisolone in multiple sclerosis.,False,Is the triple 'Hydrocortisone disrupts adrenocortical insufficiency' supported by the sentence: 'These results suggest that increasing the uric acid concentration may represent one of the possible mechanisms of action of methylprednisolone in multiple sclerosis.'?,"No, the statement does not provide indirect support for the phrase ""Hydrocortisone disrupts adrenocortical insufficiency."" The initial statement discusses methylprednisolone in multiple sclerosis and its potential mechanism involving uric acid concentration increase. Hydrocortisone is another type of corticosteroid medication entirely distinct from methylprednisolone, and adrenocortical insufficiency is an unrelated medical condition. Therefore, there is no clear connection between these two ideas based on the information provided in the statement. + To establish any relationship between meth" +20290784,Methylprednisolone related to membranous glomerulonephritis,8,"Mass co-administration of ivermectin and albendazole by the LFEP had a significant effect on STH, which was further amplified by treatment with praziquantel and albendazole 4 months later.",False,"'Does the phrase ""Methylprednisolone related to membranous glomerulonephritis"" receive at least indirect support from the statement: ""Mass co-administration of ivermectin and albendazole by the LFEP had a significant effect on STH, which was further amplified by treatment with praziquantel and albendazole 4 months later.""?","No, the statement does not provide indirect support for the phrase ""Methylprednisolone related to membranous glomerulonephritis."" The statement discusses the effects of ivermectin, albendazole, and praziquantel on Strongyloides stercoralis (STH), but it does not mention methylprednisolone or membranous glomerulonephritis at all. Therefore, there is no basis for inferring any relationship between these concepts from the given statement." +20286711,Methylprednisolone related to neuromyelitis optica,9,The effect of single dose ivermectin alone or in combination with albendazole on Wuchereria bancrofti infection in primary school children in Tanzania.,False,"'Does the phrase ""Methylprednisolone related to neuromyelitis optica"" receive at least indirect support from the statement: ""The effect of single dose ivermectin alone or in combination with albendazole on Wuchereria bancrofti infection in primary school children in Tanzania.""?","No, the statement does not provide indirect support for the phrase ""Methylprednisolone related to neuromyelitis optica"". - To further clarify: - - - Hydrocortisone is a corticosteroid medication primarily used for adrenocortical insufficiency (Addison's disease) treatment because it replaces missing cortisol in patients suffering from insufficient adrenal gland function. - - - Methylprednisolone is another corticosteroid medication commonly used for its anti-inflammatory properties in various conditions like multiple sclerosis (MS) exacerbations. - - - The statement suggests that methylprednisolone may influence uric acid concentration as" -26428860,Hydrocortisone disrupts leukemia,460,"OBJECTIVE: Compare the therapeutic efficacy of an oral/metered-dose inhaler (oral/MDI) regimen to an intravenous/nebulizer (I.V./neb) regimen of methylprednisolone, cefuroxime, and inhaled albuterol and ipratropium bromide in patients hospitalized for exacerbations of chronic obstructive pulmonary disease (COPD).",False,"Is the triple 'Hydrocortisone disrupts leukemia' supported by the sentence: 'OBJECTIVE: Compare the therapeutic efficacy of an oral/metered-dose inhaler (oral/MDI) regimen to an intravenous/nebulizer (I.V./neb) regimen of methylprednisolone, cefuroxime, and inhaled albuterol and ipratropium bromide in patients hospitalized for exacerbations of chronic obstructive pulmonary disease (COPD).'?","No, the statement does not provide any direct or indirect support for the phrase ""Hydrocortisone disrupts leukemia."" The objective in question pertains to comparing the therapeutic efficacy of different drug regimens for COPD exacerbations in hospitalized patients. Hydrocortisone is not mentioned in the objective, nor is leukemia. The drugs mentioned in the objective (methylprednisolone, cefuroxime, albuterol, ipratropium bromide) have no direct association with hydrocortisone or leukemia in this context. + The statement discusses a study on the effect of single dose ivermectin alone or in combination with albendazole on Wuchereria bancrofti infection in primary school children in Tanzania. This study is not related to Methylprednisolone or neuromyelitis optica in any way. - However, hydrocortisone is a type of corticosteroid that can be used as an anti-inflammatory agent in treating various conditions such as leukemia. But since there is no mention of hydrocortisone or leukemia in the statement provided, it does not support the claim that hydrocortisone disrupts leukemia." -26389045,Hydrocortisone disrupts neoplasm,461,"Similar to the CRPS clinical response to glucocorticoids, we now demonstrate that chronic hindpaw edema in the sciatic transection CRPS model is reversed by a continuous infusion of MP (3 mg/kg/day over 21 days), and this anti-edematous effect persists for at least 1 week after discontinuing MP.",False,"Is the triple 'Hydrocortisone disrupts neoplasm' supported by the sentence: 'Similar to the CRPS clinical response to glucocorticoids, we now demonstrate that chronic hindpaw edema in the sciatic transection CRPS model is reversed by a continuous infusion of MP (3 mg/kg/day over 21 days), and this anti-edematous effect persists for at least 1 week after discontinuing MP.'?","No, the statement does not provide direct or indirect support for the phrase ""Hydrocortisone disrupts neoplasm."" The statement discusses an experiment where chronic hindpaw edema in a sciatic transection Complex Regional Pain Syndrome (CRPS) model is reversed by a continuous infusion of MP (a glucocorticoid). However, it does not mention hydrocortisone, another type of glucocorticoid, nor does it discuss neoplasms (abnormal tissue growths that can become cancerous). Therefore, there is no connection that can be inferred between hydrocortisone and disrupting neoplasms from this statement." -26128287,Hydrocortisone disrupts melanoma,462,STUDY OBJECTIVES: To assess whether IV methylprednisolone exerts a specific early effect on dyspnea in patients with an exacerbation of asthma.,False,Is the triple 'Hydrocortisone disrupts melanoma' supported by the sentence: 'STUDY OBJECTIVES: To assess whether IV methylprednisolone exerts a specific early effect on dyspnea in patients with an exacerbation of asthma.'?,"No, the statement does not provide indirect support for the phrase ""Hydrocortisone disrupts melanoma"". The study objective is assessing the effect of intravenous methylprednisolone on dyspnea in patients with asthma exacerbation. This investigation focuses on methylprednisolone and its impact on asthma symptoms; it does not involve hydrocortisone or melanoma in any capacity. To provide indirect support for ""Hydrocortisone disrupts melanoma"", there would need to be some mention or implication of hydrocortisone negatively affecting melanoma in either the study design, methodology, results, or conclusion; however, that is not evident in this particular study objective statement." -21020907,Hydrocortisone disrupts pneumonia,463,REVIEWER'S CONCLUSIONS: Cyclophosphamide regimen treatment is a form of care in neuropsychiatric involvement in systemic lupus erythematosus with no evidence to prove better effectiveness and safety when compared with methylprednisolone.,False,Is the triple 'Hydrocortisone disrupts pneumonia' supported by the sentence: 'REVIEWER'S CONCLUSIONS: Cyclophosphamide regimen treatment is a form of care in neuropsychiatric involvement in systemic lupus erythematosus with no evidence to prove better effectiveness and safety when compared with methylprednisolone.'?,"No, the statement does not provide indirect support for the phrase ""Hydrocortisone disrupts pneumonia."" The reviewer's conclusion focuses on comparing the effectiveness and safety between cyclophosphamide regimen treatment and methylprednisolone in neuropsychiatric involvement in systemic lupus erythematosus (SLE). Hydrocortisone is a type of corticosteroid like methylprednisolone, but the statement does not mention any connection between hydrocortisone and pneumonia disruption. + Methylprednisolone is a corticosteroid used to treat various conditions such as inflammation and allergies, while neuromyelitis optica is an autoimmune disease affecting the optic nerve and spinal cord. The study mentioned focuses on filariasis, which is an infectious tropical disease caused by parasitic worms of the Filarioidea type. - However, it is important to note that corticosteroids like hydrocortisone and methylprednisolone can have immunosuppressive effects which might increase susceptibility to infections such as pneumonia if not properly managed. Nonetheless, based on the information provided in the reviewer's conclusion alone, there is no concrete evidence nor implicit connection supporting the claim that hydrocortisone disrupts pneumonia." -15895489,Hydrocortisone disrupts obesity disorder,464,"RESULTS: Both methylprednisolone and dexamethasone significantly reduced swelling and trismus (P < .05, Kruskal-Wallis test), whereas the methylprednisolone group had significantly less pain (P < .05, Kruskal-Wallis test) and consumed a lower amount of analgesics (P < .05, chi2 test) during the early postoperative days.",False,"Is the triple 'Hydrocortisone disrupts obesity disorder' supported by the sentence: 'RESULTS: Both methylprednisolone and dexamethasone significantly reduced swelling and trismus (P < .05, Kruskal-Wallis test), whereas the methylprednisolone group had significantly less pain (P < .05, Kruskal-Wallis test) and consumed a lower amount of analgesics (P < .05, chi2 test) during the early postoperative days.'?","No, the statement does not provide indirect support for the phrase ""Hydrocortisone disrupts obesity disorder."" The statement discusses results from a study involving methylprednisolone and dexamethasone, which are synthetic glucocorticoids used primarily for their anti-inflammatory effects. Hydrocortisone is also a glucocorticoid but has both glucocorticoid and mineralocorticoid activity. + Therefore, there is no connection between these two pieces of information, making it impossible for the statement to indirectly support the phrase ""Methylprednisolone related to neuromyelitis optica""." +19340184,Methylprednisolone related to chronic obstructive pulmonary disease,10,"Additionally, compared with albendazole, it resulted in a significant reduction in adult worm and total larval counts; moreover, it caused a decrease in the number of larvae deposited in muscles, with a highly significant decrease in the inflammatory cell infiltrate around the larvae and a considerable decrease in the expression of the angiogenic marker vascular endothelial growth factor in muscles.",False,"'Does the phrase ""Methylprednisolone related to chronic obstructive pulmonary disease"" receive at least indirect support from the statement: ""Additionally, compared with albendazole, it resulted in a significant reduction in adult worm and total larval counts; moreover, it caused a decrease in the number of larvae deposited in muscles, with a highly significant decrease in the inflammatory cell infiltrate around the larvae and a considerable decrease in the expression of the angiogenic marker vascular endothelial growth factor in muscles.""?","No, the statement does not provide indirect support for the phrase ""Methylprednisolone related to chronic obstructive pulmonary disease"". The statement discusses the effects of Methylprednisolone on adult worms, total larval counts, larvae deposited in muscles, inflammatory cell infiltrate around larvae, and vascular endothelial growth factor expression in muscles—none of which relate directly to chronic obstructive pulmonary disease (COPD). While Methylprednisolone is indeed a corticosteroid used in treating inflammatory diseases such as COPD, the provided statement does not offer any evidence connecting Methylprednisolone specifically to COPD in any way." +18938435,Methylprednisolone related to graft versus host disease,11,"Quarterly albendazole during childhood was associated with reduced incidence of clinical malaria (HR 0.85 (95% CI 0.73-0.98), p = 0.03).",False,"'Does the phrase ""Methylprednisolone related to graft versus host disease"" receive at least indirect support from the statement: ""Quarterly albendazole during childhood was associated with reduced incidence of clinical malaria (HR 0.85 (95% CI 0.73-0.98), p = 0.03).""?","No, the statement does not provide indirect support for the phrase ""Methylprednisolone related to graft versus host disease"". - - The study results indicate that methylprednisolone and dexamethasone have an impact on swelling, trismus (a limited ability to open one's mouth), pain, and analgesic consumption in postoperative days; however, it does not provide evidence that hydrocortisone has any effect on obesity disorder. + The statement discusses the association between quarterly albendazole during childhood and reduced incidence of clinical malaria. This has no direct or indirect relation to methylprednisolone or graft versus host disease. Methylprednisolone is a corticosteroid used primarily for its anti-inflammatory effects, and graft versus host disease is a condition that occurs when transplanted tissue (graft) attacks the recipient's body (host). These concepts are distinct from the drugs and conditions mentioned in the statement. Therefore, it does not offer any support for the stated phrase." +17333962,Methylprednisolone related to Inflammation,12,CONCLUSIONS: Mebendazole and albendazole showed reduced efficacy against Ascaris lumbricoides and hookworm infections at the recommended doses.,False,"'Does the phrase ""Methylprednisolone related to Inflammation"" receive at least indirect support from the statement: ""CONCLUSIONS: Mebendazole and albendazole showed reduced efficacy against Ascaris lumbricoides and hookworm infections at the recommended doses.""?","No, the statement does not provide indirect support for ""Methylprednisolone related to Inflammation."" The conclusion is about the reduced efficacy of two drugs, Mebendazole and Albendazole, against certain parasitic infections. It does not mention Methylprednisolone nor inflammation. Methylprednisolone is a corticosteroid often used to reduce inflammation, but there is no connection made in this statement." +17288506,Methylprednisolone related to autoimmune thrombocytopenic purpura,13,Evaluation of effectiveness of diethylcarbamazine/albendazole combination in reduction of Wuchereria bancrofti infection using multiple infection parameters.,False,"'Does the phrase ""Methylprednisolone related to autoimmune thrombocytopenic purpura"" receive at least indirect support from the statement: ""Evaluation of effectiveness of diethylcarbamazine/albendazole combination in reduction of Wuchereria bancrofti infection using multiple infection parameters.""?","No, the statement does not provide indirect support for the phrase ""Methylprednisolone related to autoimmune thrombocytopenic purpura."" The statement is an evaluation of the effectiveness of a drug combination (diethylcarbamazine/albendazole) in reducing Wuchereria bancrofti infection using multiple infection parameters. This topic is unrelated to Methylprednisolone and autoimmune thrombocytopenic purpura. Methylprednisolone is a corticosteroid used for its anti-inflammatory effects in various conditions, while autoimmune thrombocytopenic purpura is a disorder in which the immune system mistakenly attacks and destroys platelets, which are necessary for normal blood clotting. Therefore, there is no connection between these two distinct areas of medical research." +15936572,Methylprednisolone related to endocrine exophthalmos,14,"Our evaluation suggests that although additional studies are needed to determine optimal treatment regimens for intestinal parasites, especially among young children and pregnant women, a five-day course of pre-departure albendazole was effective in reducing helminthic infection in treated refugees.",False,"'Does the phrase ""Methylprednisolone related to endocrine exophthalmos"" receive at least indirect support from the statement: ""Our evaluation suggests that although additional studies are needed to determine optimal treatment regimens for intestinal parasites, especially among young children and pregnant women, a five-day course of pre-departure albendazole was effective in reducing helminthic infection in treated refugees.""?","No, the statement does not provide indirect support for the phrase ""Methylprednisolone related to endocrine exophthalmos"". - - The three glucocorticoids mentioned have different potencies and may have varying impacts on different physiological processes; therefore, it is not appropriate to generalize these study results to hydrocortisone's effect on obesity disorder without further investigation. + The statement is about a study evaluating the effectiveness of pre-departure albendazole treatment in reducing helminthic infection in refugees. It does not mention methylprednisolone, endocrine exophthalmos, or any related concepts. Therefore, it does not offer any form of support for the stated phrase. - - In summary, while these results may contribute to" -15750557,Hydrocortisone disrupts injury,465,Methylprednisolone only inhibited granulocytopenia and thrombocytopenia when zymosan-activated serum or fibrinogen-depleted plasma were infused.,False,Is the triple 'Hydrocortisone disrupts injury' supported by the sentence: 'Methylprednisolone only inhibited granulocytopenia and thrombocytopenia when zymosan-activated serum or fibrinogen-depleted plasma were infused.'?,"No, the statement does not provide indirect support for the phrase ""Hydrocortisone disrupts injury."" The statement discusses the effects of Methylprednisolone on granulocytopenia and thrombocytopenia when certain substances are infused, but it does not mention Hydrocortisone or provide any information about its potential impact on injury. Therefore, it does not offer any implicit or indirect evidence for the claim about Hydrocortisone disruption of injury." -8865955,Hydrocortisone disrupts Inflammation,466,"In addition, we detected that sufentanil provided prolonged pain relief up to 24 h when compared with control, whereas when we combined sufentanil plus methylprednisolone, we found that it further reduced pain and use of analgesics when compared with sufentanil.",False,"Is the triple 'Hydrocortisone disrupts Inflammation' supported by the sentence: 'In addition, we detected that sufentanil provided prolonged pain relief up to 24 h when compared with control, whereas when we combined sufentanil plus methylprednisolone, we found that it further reduced pain and use of analgesics when compared with sufentanil.'?","No, the statement does not provide direct or indirect support for the phrase ""Hydrocortisone disrupts Inflammation"". The statement discusses the effects of sufentanil and methylprednisolone on pain relief and use of analgesics, but it does not mention hydrocortisone or its impact on inflammation." -26205555,Hydrocortisone prevents neoplasm,467,These findings demonstrate that MP may suppress post-traumatic inflammatory reaction by inhibiting both the AP-1 and NF-kappaB transcription cascades via a GR mechanism.,False,Is the triple 'Hydrocortisone prevents neoplasm' supported by the sentence: 'These findings demonstrate that MP may suppress post-traumatic inflammatory reaction by inhibiting both the AP-1 and NF-kappaB transcription cascades via a GR mechanism.'?,"No, the statement does not provide direct or indirect support for the phrase ""Hydrocortisone prevents neoplasm."" The initial statement discusses how MP (presumably an abbreviation for a specific molecule or treatment) may suppress post-traumatic inflammatory reactions by inhibiting certain transcription cascades via a GR mechanism. While hydrocortisone is a type of glucocorticoid (GR) that has anti-inflammatory properties, it does not necessarily mean that hydrocortisone prevents neoplasms (abnormal growths that can lead to cancer). The provided statement focuses on inflammation rather than neoplasm prevention. Additionally, hydrocortisone's potential impact on neoplasm prevention would require separate evidence and investigation into its effects on cellular growth, differentiation, and apoptosis pathways related to neoplasm formation." -19342068,Hydrocortisone prevents obesity disorder,468,"This study assessed the effectiveness of a ganciclovir, methylprednisolone, and immunoglobulin combination (TAGMIC) therapy in decreasing cognitive impairment and mortality among patients with Japanese encephalitis.",False,"Is the triple 'Hydrocortisone prevents obesity disorder' supported by the sentence: 'This study assessed the effectiveness of a ganciclovir, methylprednisolone, and immunoglobulin combination (TAGMIC) therapy in decreasing cognitive impairment and mortality among patients with Japanese encephalitis.'?","No, the statement does not provide indirect support for the phrase ""Hydrocortisone prevents obesity disorder"". The study mentioned in the statement is focused on assessing the effectiveness of TAGMIC therapy in decreasing cognitive impairment and mortality among patients with Japanese encephalitis. Hydrocortisone is not mentioned in the study, nor is there any connection made between TAGMIC therapy and obesity disorder prevention." -19245686,Hydrocortisone prevents toxic shock syndrome,469,"From indirect comparisons, most interventions showed decreased risk of developing RA compared to placebo at 12 months, reaching statistical significance for methotrexate (OR 0.16 [95% CI 0.08, 0.33]) and intramuscular methylprednisolone (OR 0.72 [95% CI 0.53, 0.99]).",False,"Is the triple 'Hydrocortisone prevents toxic shock syndrome' supported by the sentence: 'From indirect comparisons, most interventions showed decreased risk of developing RA compared to placebo at 12 months, reaching statistical significance for methotrexate (OR 0.16 [95% CI 0.08, 0.33]) and intramuscular methylprednisolone (OR 0.72 [95% CI 0.53, 0.99]).'?","No, the statement does not provide indirect support for the claim that hydrocortisone prevents toxic shock syndrome. The statement discusses the effects of various interventions on reducing the risk of developing rheumatoid arthritis (RA) at 12 months. Hydrocortisone is not mentioned in the study, and intramuscular methylprednisolone is not equivalent to hydrocortisone in terms of its effects on toxic shock syndrome. + Endocrine exophthalmos is often associated with Graves' disease, an autoimmune disorder that can cause bulging eyes due to inflammation of the eye muscles and fatty tissue behind the eyes. Methylprednisolone is a corticosteroid that can be used to treat inflammation in various conditions, including endocrine exophthalmos. However, the statement provided does not discuss these topics, so it cannot provide indirect support for the stated phrase." +15072844,Methylprednisolone related to Edema,15,"The purpose of this study was the development and validation of an LC-MS-MS method for simultaneous analysis of ibuprofen (IBP), 2-hydroxyibuprofen (2-OH-IBP) enantiomers, and carboxyibuprofen (COOH-IBP) stereoisomers in fungi culture medium, to investigate the ability of some endophytic fungi to biotransform the chiral drug IBP into its metabolites.",False,"'Does the phrase ""Methylprednisolone related to Edema"" receive at least indirect support from the statement: ""The purpose of this study was the development and validation of an LC-MS-MS method for simultaneous analysis of ibuprofen (IBP), 2-hydroxyibuprofen (2-OH-IBP) enantiomers, and carboxyibuprofen (COOH-IBP) stereoisomers in fungi culture medium, to investigate the ability of some endophytic fungi to biotransform the chiral drug IBP into its metabolites.""?","No, the statement ""Methylprednisolone related to Edema"" does not receive indirect support from the provided study. The purpose of the study is focused on developing an LC-MS-MS method for simultaneous analysis of ibuprofen (IBP), 2-hydroxyibuprofen (2-OH-IBP) enantiomers, and carboxyibuprofen (COOH-IBP) stereoisomers in fungi culture medium. This study does not involve methylprednisolone nor edema; hence it does not provide any indirect support for the statement ""Methylprednisolone related to Edema.""" +14876749,Methylprednisolone related to osteoarthritis,16,"AIMS: To carry out a randomized clinical trial to compare the effect of palmitoylethanolamide (PEA) versus ibuprofen, a nonsteroidal anti-inflammatory drug (NSAID), for pain relief in temporomandibular joint (TMJ) osteoarthritis or arthralgia.",False,"'Does the phrase ""Methylprednisolone related to osteoarthritis"" receive at least indirect support from the statement: ""AIMS: To carry out a randomized clinical trial to compare the effect of palmitoylethanolamide (PEA) versus ibuprofen, a nonsteroidal anti-inflammatory drug (NSAID), for pain relief in temporomandibular joint (TMJ) osteoarthritis or arthralgia.""?","No, the statement does not provide indirect support for the phrase ""Methylprednisolone related to osteoarthritis"". The statement describes a randomized clinical trial comparing the effect of PEA versus ibuprofen (an NSAID) for pain relief in TMJ osteoarthritis or arthralgia. Methylprednisolone is not mentioned in the statement, nor is any information provided that could imply its relation to osteoarthritis. Methylprednisolone is a corticosteroid commonly used to reduce inflammation and suppress the immune system in various conditions but is not directly related to osteoarthritis based on this statement alone." +14399082,Methylprednisolone related to aplastic anemia,17,"We investigated the analgesic efficacy of single doses of ibuprofen, tramadol and pregabalin in menthol-evoked cold pain in a randomized, placebo-controlled four-way cross-over study in 20 healthy volunteers.",False,"'Does the phrase ""Methylprednisolone related to aplastic anemia"" receive at least indirect support from the statement: ""We investigated the analgesic efficacy of single doses of ibuprofen, tramadol and pregabalin in menthol-evoked cold pain in a randomized, placebo-controlled four-way cross-over study in 20 healthy volunteers.""?","No, the statement does not provide indirect support for the phrase ""Methylprednisolone related to aplastic anemia."" The study investigates the analgesic efficacy of single doses of ibuprofen, tramadol, and pregabalin in menthol-evoked cold pain in a randomized, placebo-controlled four-way cross-over study in 20 healthy volunteers. Methylprednisolone is not mentioned in the study, nor is there any discussion of aplastic anemia. Therefore, it is not possible to draw any conclusions about methylprednisolone's relationship to aplastic anemia based on this statement alone." +14398237,Methylprednisolone related to IgA glomerulonephritis,18,Double blind study on emorfazone and ibuprofen in dental pain and inflammation.,False,"'Does the phrase ""Methylprednisolone related to IgA glomerulonephritis"" receive at least indirect support from the statement: ""Double blind study on emorfazone and ibuprofen in dental pain and inflammation.""?","No, the statement ""Methylprednisolone related to IgA glomerulonephritis"" does not receive any direct or indirect support from the study on emorfazone and ibuprofen in dental pain and inflammation. The two statements discuss different topics - one is about the use of methylprednisolone in IgA glomerulonephritis (a kidney disease), while the other is about the comparison of two drugs in dental pain and inflammation. Therefore, there is no relevant connection between them based on the provided information." +14278238,"Methylprednisolone related to dermatitis, atopic",19,Glucosamine sulfate compared to ibuprofen in osteoarthritis of the knee.,False,"'Does the phrase ""Methylprednisolone related to dermatitis, atopic"" receive at least indirect support from the statement: ""Glucosamine sulfate compared to ibuprofen in osteoarthritis of the knee.""?","No, the statement ""Glucosamine sulfate compared to ibuprofen in osteoarthritis of the knee"" does not provide indirect support for the phrase ""Methylprednisolone related to dermatitis, atopic"". - The statement does provide evidence that intramuscular methylprednisolone may have some protective effects against RA development compared to placebo at 12 months (OR 0.72 [95% CI 0.53, 0.99]). However, hydrocortisone is not mentioned in the study as an intervention for RA nor as a preventative measure for toxic shock syndrome. Additionally, even if hydrocortisone were mentioned in relation to toxic shock syndrome in another study, it would not provide indirect support for the claim based on this statement alone because the contexts (RA vs toxic shock syndrome) and interventions (intramuscular methylprednisolone vs hydro" -18758297,Hydrocortisone prevents injury,470,Treatment with a pulse of methylprednisolone reduced both abdominal pain and lesion size.,False,Is the triple 'Hydrocortisone prevents injury' supported by the sentence: 'Treatment with a pulse of methylprednisolone reduced both abdominal pain and lesion size.'?,"No, the statement ""Treatment with a pulse of methylprednisolone reduced both abdominal pain and lesion size"" does not provide indirect support for the phrase ""Hydrocortisone prevents injury."" + The two statements discuss different medical conditions and treatments. The first statement compares the effects of Glucosamine sulfate and Ibuprofen on osteoarthritis of the knee, while the second phrase suggests a relationship between Methylprednisolone and atopic dermatitis. - The primary reason for this is that methylprednisolone and hydrocortisone are two distinct glucocorticoids with different pharmacological properties and administration regimens. While they share some anti-inflammatory effects, they cannot be used interchangeably in all contexts due to their unique characteristics. + The lack of overlap in medical conditions (osteoarthritis vs atopic dermatitis) and treatments (Glucosamine sulfate/Ibuprofen vs Methylprednisolone) precludes any indirect support from the first statement for the second phrase." +14166179,Methylprednisolone related to cardiac arrest,20,INTRODUCTION: The anti-inflammatory and anticoagulant effects of ibuprofen and heparin may enhance skin perfusion in cutaneous scald burns.,False,"'Does the phrase ""Methylprednisolone related to cardiac arrest"" receive at least indirect support from the statement: ""INTRODUCTION: The anti-inflammatory and anticoagulant effects of ibuprofen and heparin may enhance skin perfusion in cutaneous scald burns.""?","No, the phrase ""Methylprednisolone related to cardiac arrest"" does not receive indirect support from the statement provided. The introduction statement discusses the potential benefits of ibuprofen and heparin in enhancing skin perfusion in cutaneous scald burns, focusing on their anti-inflammatory and anticoagulant effects. Methylprednisolone is not mentioned in this statement, nor is there any implicit connection that could be inferred between methylprednisolone use and cardiac arrest based on this information alone." +12755316,Methylprednisolone related to plasma cell myeloma,21,"CONCLUSIONS: Ibuprofen-induced patent ductus arteriosus closure improved pulmonary mechanics, decreased total lung water, increased epithelial sodium channel expression, and decreased the detrimental effects of preterm birth on alveolarization.",False,"'Does the phrase ""Methylprednisolone related to plasma cell myeloma"" receive at least indirect support from the statement: ""CONCLUSIONS: Ibuprofen-induced patent ductus arteriosus closure improved pulmonary mechanics, decreased total lung water, increased epithelial sodium channel expression, and decreased the detrimental effects of preterm birth on alveolarization.""?","No, the statement does not provide indirect support for the phrase ""Methylprednisolone related to plasma cell myeloma."" - Methylprednisolone is commonly used in high-dose ""pulse"" therapy for specific indications such as acute exacerbations in multiple sclerosis or severe asthma attacks due to its potent anti-inflammatory properties and relatively long duration of action compared to hydrocortisone. + The conclusion drawn in the statement is about the effects of Ibuprofen on patent ductus arteriosus closure, pulmonary mechanics, total lung water, epithelial sodium channel expression, and alveolarization in preterm births. There is no mention of Methylprednisolone or plasma cell myeloma in the statement. Therefore, it does not provide any support, direct or indirect, for the stated phrase. - Hydrocortisone, on the other hand, is often used in lower doses for more prolonged periods in various clinical settings due to its shorter half-life and more rapid clearance from the body. + Plasma cell myeloma is a type of cancer where malignant plasma cells accumulate in the bone marrow, leading to bone destruction and bone marrow failure. Methylprednisolone is a corticosteroid often used in the treatment of various conditions due to its anti-inflammatory and immunosuppressive effects. There is no clear connection between these two concepts based on the provided statement. - Therefore, even if methylprednisolone demonstrates beneficial effects" -17956690,Hydrocortisone prevents Sepsis,471,Methylprednisolone prevents propranolol-induced airway hyperreactivity in the Basenji-greyhound dog.,False,Is the triple 'Hydrocortisone prevents Sepsis' supported by the sentence: 'Methylprednisolone prevents propranolol-induced airway hyperreactivity in the Basenji-greyhound dog.'?,"No, the statement ""Methylprednisolone prevents propranolol-induced airway hyperreactivity in the Basenji-greyhound dog"" does not provide indirect support for the claim that ""Hydrocortisone prevents Sepsis."" + It is crucial to ensure that conclusions drawn from scientific statements are based on relevant evidence directly related to the topic at hand. Misinterpretation can lead to misunder" +12183687,Methylprednisolone related to acute lymphoblastic leukemia,22,Protein profile in neuroblastoma cells incubated with S- and R-enantiomers of ibuprofen by iTRAQ-coupled 2-D LC-MS/MS analysis: possible action of induced proteins on Alzheimer's disease.,False,"'Does the phrase ""Methylprednisolone related to acute lymphoblastic leukemia"" receive at least indirect support from the statement: ""Protein profile in neuroblastoma cells incubated with S- and R-enantiomers of ibuprofen by iTRAQ-coupled 2-D LC-MS/MS analysis: possible action of induced proteins on Alzheimer's disease.""?","No, the statement does not provide any indirect support for the phrase ""Methylprednisolone related to acute lymphoblastic leukemia"". The statement discusses the protein profile in neuroblastoma cells incubated with S-and R-enantiomers of ibuprofen, and potential actions of induced proteins on Alzheimer's disease. This statement is not related to Methylprednisolone or acute lymphoblastic leukemia in any way. Methylprednisolone is a corticosteroid used for its anti-inflammatory effects, while acute lymphoblastic leukemia is a type of cancer of the white blood cells. Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID), neuroblastoma is a type of cancer that forms in nerve tissue, and Alzheimer's disease is a progressive disorder that causes brain cells to waste away (degenerate) and die. These topics are distinct from each other and there is no connection established in the provided statement." +11720471,Methylprednisolone related to systemic lupus erythematosus,23,Protective effect of glucosamine against ibuprofen-induced peptic ulcer in rats.,False,"'Does the phrase ""Methylprednisolone related to systemic lupus erythematosus"" receive at least indirect support from the statement: ""Protective effect of glucosamine against ibuprofen-induced peptic ulcer in rats.""?","No, the statement ""Protective effect of glucosamine against ibuprofen-induced peptic ulcer in rats"" does not provide indirect support for the phrase ""Methylprednisolone related to systemic lupus erythematosus"". - The reason for my decision is as follows: + The statement pertains to the protective effect of glucosamine against ibuprofen-induced peptic ulcers in rats. This has no direct or indirect relation to methylprednisolone or systemic lupus erythematosus (SLE). Methylprednisolone is a corticosteroid used primarily for its anti-inflammatory effects in conditions such as asthma, rheumatoid arthritis, and SLE. The protective effect of glucosamine against ibuprofen-induced peptic ulcers in rats does not imply any connection or relationship between methylprednisolone and SLE. - While both hydrocortisone and methylprednisolone are glucocorticoids used as anti-inflammatory agents in different medical contexts, they have distinct pharmacological profiles that may not translate directly from one application to another. The study involving methylprednisolone focuses on its ability to prevent propranolol-induced airway hyperreactivity in a specific canine breed, which is quite different from sepsis in humans - the condition that hydrocortisone is often used to prevent or treat. + It is essential to evaluate scientific claims based on their direct relevance and logical connections. In this case, the two statements do not share a common theme or finding that would allow for indirect support to be" +10812685,Methylprednisolone related to immunoglobulin a vasculitis,24,Ibuprofen-induced fever in Sjogren's syndrome.,False,"'Does the phrase ""Methylprednisolone related to immunoglobulin a vasculitis"" receive at least indirect support from the statement: ""Ibuprofen-induced fever in Sjogren's syndrome.""?","No, the statement ""Ibuprofen-induced fever in Sjogren's syndrome"" does not provide indirect support for the phrase ""Methylprednisolone related to immunoglobulin A vasculitis."" - Sepsis is characterized by a dysregulated immune response leading to organ dysfunction and is often associated with infections caused by bacteria, viruses, or fungi. Hydrocortisone is thought to modulate immune function in sepsis by preventing excessive inflammation while maintaining adequate" -16963888,Hydrocortisone prevents adrenocortical insufficiency,472,Administration of methylprednisolone to prevent severe ovarian hyperstimulation syndrome in patients undergoing in vitro fertilization.,False,Is the triple 'Hydrocortisone prevents adrenocortical insufficiency' supported by the sentence: 'Administration of methylprednisolone to prevent severe ovarian hyperstimulation syndrome in patients undergoing in vitro fertilization.'?,"No, the statement does not provide direct or indirect support for the phrase ""Hydrocortisone prevents adrenocortical insufficiency."" Methylprednisolone is a synthetic glucocorticoid used in various clinical settings, including preventing severe ovarian hyperstimulation syndrome in patients undergoing in vitro fertilization. Hydrocortisone is also a glucocorticoid but has a different chemical structure and is primarily used in treating adrenocortical insufficiency by replacing deficient hormones in patients suffering from conditions like Addison's disease. + The two statements discuss different medical conditions and treatments. The first statement refers to a fever induced by Ibuprofen in Sjogren's syndrome, which is an autoimmune disorder characterized by dry eyes and mouth. The second phrase refers to Methylprednisolone, a corticosteroid used often in treating immunoglobulin A vasculitis (IgAV), formerly known as Henoch-Schönlein purpura, an autoimmune condition that causes inflammation in small blood vessels. - The two statements mention different glucocorticoids being used for distinct medical indications; thus, they do not offer any support for the claim that hydrocortisone prevents adrenocortical insufficiency. However, understanding how various glucocorticoids work in different clinical situations may inform future studies on hydrocortisone use in adrenocortical insufficiency prevention or treatment." -15550113,Hydrocortisone prevents Inflammation,473,"Combined methylprednisolone, bupivacaine and morphine reduced pain, joint swelling, time of immobilization, duration of sick leave and return to sports after the arthroscopic procedure.",False,"Is the triple 'Hydrocortisone prevents Inflammation' supported by the sentence: 'Combined methylprednisolone, bupivacaine and morphine reduced pain, joint swelling, time of immobilization, duration of sick leave and return to sports after the arthroscopic procedure.'?","No, the statement does not provide direct or indirect support for the phrase ""Hydrocortisone prevents Inflammation."" The statement discusses the effects of combined methylprednisolone, bupivacaine, and morphine on pain, joint swelling, time of immobilization, duration of sick leave, and return to sports after an arthroscopic procedure. Methylprednisolone is a type of corticosteroid like hydrocortisone; however, it is not hydrocortisone itself, and the statement does not explicitly connect these treatments to inflammation prevention. + Although both statements discuss autoimmune disorders and treatments, they do not share any direct correlation in terms of underlying mechanisms, triggers, or therapeutic interventions. The lack of commonality in pathophysiology between Sjogren's syndrome and IgAV further weakens any potential indirect link between Ibuprofen-induced fever in Sjogren's syndrome" +10763477,Methylprednisolone related to ulcerative colitis,25,There have been no prior definite cases reported of ibuprofen-induced pancreatitis.,False,"'Does the phrase ""Methylprednisolone related to ulcerative colitis"" receive at least indirect support from the statement: ""There have been no prior definite cases reported of ibuprofen-induced pancreatitis.""?","No, the statement ""There have been no prior definite cases reported of ibuprofen-induced pancreatitis"" does not provide indirect support for the phrase ""Methylprednisolone related to ulcerative colitis."" - To provide indirect support for ""Hydrocortisone prevents Inflammation,"" there would need to be evidence linking hydrocortisone specifically to inflammation prevention or some connection between methylprednisolone's effect on inflammation and hydrocortisone's potential effects on inflammation. Since no such connection is made in the statement provided, it does not offer support for the original phrase." -15540854,Hydrocortisone prevents pneumonia,474,Forty-eight patients who underwent bone marrow transplantation (BMT) from serologically HLA-matched unrelated donors received tacrolimus (FK506) alone or with methotrexate (MTX) and/or methylprednisolone (mPSL) to prevent graft-versus-host disease (GVHD).,False,Is the triple 'Hydrocortisone prevents pneumonia' supported by the sentence: 'Forty-eight patients who underwent bone marrow transplantation (BMT) from serologically HLA-matched unrelated donors received tacrolimus (FK506) alone or with methotrexate (MTX) and/or methylprednisolone (mPSL) to prevent graft-versus-host disease (GVHD).'?,"No, the statement does not provide indirect support for the claim that ""Hydrocortisone prevents pneumonia."" The statement discusses patients who underwent bone marrow transplantation (BMT) from serologically HLA-matched unrelated donors and received various medications (tacrolimus (FK506), methotrexate (MTX), methylprednisolone (mPSL)) as prophylaxis for graft-versus-host disease (GVHD). Hydrocortisone is not mentioned in the statement as one of these medications, so it does not offer any support for the claim about hydrocortisone preventing pneumonia. + The two statements discuss different drugs (ibuprofen and methylprednisolone) and different medical conditions (pancreatitis and ulcerative colitis). Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) while methylprednisolone is a corticosteroid; they have different mechanisms of action in the body. - The statement instead focuses on medications used in preventing GVHD in patients who underwent BMT from unrelated donors. It does not discuss any potential effects these medications might have on pneumonia prevention nor does it mention hydrocortisone as one of these medications in question. Therefore, it is not reasonable to infer any indirect support for hydrocortisone preventing pneumonia from this statement alone." -14020540,Hydrocortisone prevents bronchopulmonary dysplasia,475,"Thus, calpeptin and methylprednisolone are found to be neuroprotective in SCI.",False,"Is the triple 'Hydrocortisone prevents bronchopulmonary dysplasia' supported by the sentence: 'Thus, calpeptin and methylprednisolone are found to be neuroprotective in SCI.'?","No, the statement does not provide indirect support for the phrase ""Hydrocortisone prevents bronchopulmonary dysplasia."" The two statements discuss different subjects: one focuses on neuroprotection in spinal cord injuries (SCI) using calpeptin and methylprednisolone, while the other addresses bronchopulmonary dysplasia prevention using hydrocortisone. + The lack of reported ibuprofen-induced pancreatitis cases does not imply that methylprednisolone has any connection to ulcerative colitis. Ulcerative colitis is an inflammatory bowel disease (IBD) that affects the colon and rectum lining; methylprednisolone is often used as an anti-inflammatory agent in treating IBD due to its ability to reduce inflammation in the gut. - To further clarify, let us analyze the components of each statement: + Therefore, more specific evidence connecting methylprednisolone" +10558884,Methylprednisolone related to lupus nephritis,26,"RESULTS: None of the studies established any of the COX-2 inhibitors as clearly better than ibuprofen, the current gold standard for the treatment of surgically induced dental pain.",False,"'Does the phrase ""Methylprednisolone related to lupus nephritis"" receive at least indirect support from the statement: ""RESULTS: None of the studies established any of the COX-2 inhibitors as clearly better than ibuprofen, the current gold standard for the treatment of surgically induced dental pain.""?","No, the statement does not provide indirect support for the phrase ""Methylprednisolone related to lupus nephritis"". The provided result is about COX-2 inhibitors and their efficacy in treating surgically induced dental pain compared to ibuprofen. Methylprednisolone is a corticosteroid used primarily for its anti-inflammatory effects in various conditions, such as lupus nephritis flares. The two statements discuss different subjects – one being COX-2 inhibitors in dental pain management and the other being Methylprednisolone in lupus nephritis management – thus they do not provide indirect support for each other." +10130342,Methylprednisolone related to adult acute respiratory distress syndrome,27,Noncardiogenic pulmonary edema due to ibuprofen.,False,"'Does the phrase ""Methylprednisolone related to adult acute respiratory distress syndrome"" receive at least indirect support from the statement: ""Noncardiogenic pulmonary edema due to ibuprofen.""?","No, the statement ""Noncardiogenic pulmonary edema due to ibuprofen"" does not provide indirect support for the phrase ""Methylprednisolone related to adult acute respiratory distress syndrome."" - - ""Thus, calpeptin and methylprednisolone are found to be neuroprotective in SCI."" This statement implies that calpeptin and methylprednisolone have protective effects on nerve cells in spinal cord injuries. + The two statements discuss different drugs and their respective effects on lung conditions. Ibuprofen is associated with noncardiogenic pulmonary edema, while methylprednisolone is not mentioned in this context at all. Methylprednisolone is a corticosteroid often used in treating various conditions such as inflammation, allergies, and autoimmune disorders; it has not been directly linked to adult acute respiratory distress syndrome in the provided statement. - - ""Hydrocortisone prevents bronchopulmonary dysplasia."" This statement suggests that hydrocortisone has the ability to prevent bronchopulmonary dysplasia, which is a chronic lung disease affecting premature infants. + To establish indirect support between these statements, there should be some connection between ibuprofen-induced pulmonary edema and methylprednisolone-induced adult acute respiratory distress syndrome; however, no such connection is evident in these statements." +9229208,Methylprednisolone related to vestibular neuronitis,28,"In a double-blind cross-over study on 22 healthy subjects the analgesic efficacies of the antipyretic analgesic drugs ibuprofen, dipyrone and paracetamol were tested against placebo using a model of experimentally induced pain.",False,"'Does the phrase ""Methylprednisolone related to vestibular neuronitis"" receive at least indirect support from the statement: ""In a double-blind cross-over study on 22 healthy subjects the analgesic efficacies of the antipyretic analgesic drugs ibuprofen, dipyrone and paracetamol were tested against placebo using a model of experimentally induced pain.""?","No, the statement does not provide indirect support for the phrase ""Methylprednisolone related to vestibular neuronitis"". The study mentioned in the statement investigates the analgesic efficacies of ibuprofen, dipyrone, paracetamol, and placebo in healthy subjects using an experimentally induced pain model. Methylprednisolone is not mentioned in the study, nor is there any connection made between methylprednisolone and vestibular neuronitis. To establish indirect support for the phrase ""Methylprednisolone related to vestibular neuronitis"", there should be some link between methylprednisolone and either vestibular neuronitis or pain management in general. Since no such link is present in the statement provided, it does not offer indirect support for the phrase in question." +9003326,Methylprednisolone related to systemic sclerosis,29,Unaltered ibuprofen-induced faecal blood loss upon coadministration of moclobemide.,False,"'Does the phrase ""Methylprednisolone related to systemic sclerosis"" receive at least indirect support from the statement: ""Unaltered ibuprofen-induced faecal blood loss upon coadministration of moclobemide.""?","No, the statement ""Unaltered ibuprofen-induced faecal blood loss upon coadministration of moclobemide"" does not provide indirect support for the phrase ""Methylprednisolone related to systemic sclerosis"". - As both statements discuss different medical conditions and therapeutic agents, there is no indirect support linking hydrocortisone preventing bronchopulmonary dyspl" -13075196,Hydrocortisone prevents atrial fibrillation,476,"Methylprednisolone prevents the development of autotomy and neuropathic edema in rats, but has no effect on nociceptive thresholds.",False,"Is the triple 'Hydrocortisone prevents atrial fibrillation' supported by the sentence: 'Methylprednisolone prevents the development of autotomy and neuropathic edema in rats, but has no effect on nociceptive thresholds.'?","No, the statement does not provide indirect support for the phrase ""Hydrocortisone prevents atrial fibrillation."" The reason is that Methylprednisolone, not Hydrocortisone, is being tested in the experiment described in the statement. Furthermore, Methylprednisolone is shown to have an effect on autotomy and neuropathic edema in rats but not on nociceptive thresholds; atrial fibrillation is not addressed in any capacity in this statement. To provide indirect support for ""Hydrocortisone prevents atrial fibrillation,"" there would need to be some connection between methylprednisolone or its effects on rats and hydrocortisone or its effects on atrial fibrillation in humans; however, no such connection is evident in the statement provided." -12187318,Hydrocortisone prevents Insulin resistance,477,Chronically impaired renal function and the use of methylprednisolone may be the risk factors for SP.,False,Is the triple 'Hydrocortisone prevents Insulin resistance' supported by the sentence: 'Chronically impaired renal function and the use of methylprednisolone may be the risk factors for SP.'?,"No, the statement does not provide indirect support for the phrase ""Hydrocortisone prevents Insulin resistance."" The statement ""Chronically impaired renal function and the use of methylprednisolone may be the risk factors for SP"" is discussing factors that could potentially lead to secondary pulmonary hypertension (SP). Methylprednisolone is a type of corticosteroid like hydrocortisone, but it does not imply that hydrocortisone prevents insulin resistance. + The statement pertains to a study involving ibuprofen, faecal blood loss, and moclobemide. It does not mention methylprednisolone or systemic sclerosis. Methylprednisolone is a corticosteroid used to suppress inflammation in various conditions including systemic sclerosis, but it is not mentioned in the provided statement. Therefore, there is no connection between the two phrases in terms of their subject matter. - Insulin resistance is a condition where body cells do not respond properly to insulin, leading to high blood sugar levels. Hydrocortisone is known for its glucocorticoid activity, which can increase blood sugar levels by reducing insulin sensitivity in some cases. Therefore, it is unlikely that hydrocortisone prevents insulin resistance based on current knowledge. + Furthermore, even if methylprednisolone was mentioned in the statement, it would still not provide indirect support without additional context linking it to systemic sclerosis. The relationship between methylprednisolone and systemic sclerosis is complex and not necessarily implied by coadministration of other drugs. Therefore, without explicit mention of both methylprednisolone and systemic sclerosis" +8447481,Methylprednisolone related to rheumatoid arthritis,30,The C5a antagonist (1 or 3 mg/kg/day) and/or ibuprofen (30 mg/kg/day) were administered orally on a daily basis either before or after arthritis induction.,False,"'Does the phrase ""Methylprednisolone related to rheumatoid arthritis"" receive at least indirect support from the statement: ""The C5a antagonist (1 or 3 mg/kg/day) and/or ibuprofen (30 mg/kg/day) were administered orally on a daily basis either before or after arthritis induction.""?","No, the phrase ""Methylprednisolone related to rheumatoid arthritis"" does not receive indirect support from the statement provided. The statement discusses the administration of C5a antagonist (1 or 3 mg/kg/day) and/or ibuprofen (30 mg/kg/day) before or after arthritis induction but does not mention Methylprednisolone at all. Methylprednisolone is a type of corticosteroid used for treating various conditions such as rheumatoid arthritis; however, it is not mentioned in the statement provided. Therefore, there is no indirect support for the connection between Methylprednisolone and rheumatoid arthritis from the given statement." +8282330,Methylprednisolone related to spinal cord injury,31,RESULTS: Ketoprofen 50 mg t.d.s. suppressed prostaglandin synthesis to a significantly greater extent than ibuprofen and caused significantly more gastroduodenal injury.,False,"'Does the phrase ""Methylprednisolone related to spinal cord injury"" receive at least indirect support from the statement: ""RESULTS: Ketoprofen 50 mg t.d.s. suppressed prostaglandin synthesis to a significantly greater extent than ibuprofen and caused significantly more gastroduodenal injury.""?","No, the statement does not provide indirect support for the phrase ""Methylprednisolone related to spinal cord injury"". - It is important to differentiate between discussing risk factors for developing certain conditions (SP) versus protective factors that prevent conditions (insulin resistance). The two statements provided here discuss different concepts related to different medical issues." -14643692,Hydrocortisone exacerbates Sepsis,478,"Because a common therapy for acute spinal cord injury is the use of an antiinflammatory synthetic glucocorticoid (methylprednisolone), we sought to determine mechanisms contributing to inflammation shortly after acute injury.",False,"Is the triple 'Hydrocortisone exacerbates Sepsis' supported by the sentence: 'Because a common therapy for acute spinal cord injury is the use of an antiinflammatory synthetic glucocorticoid (methylprednisolone), we sought to determine mechanisms contributing to inflammation shortly after acute injury.'?","No, the statement does not provide indirect support for the phrase ""Hydrocortisone exacerbates Sepsis."" The statement discusses the use of an anti-inflammatory synthetic glucocorticoid (methylprednisolone) in acute spinal cord injury and its contribution to inflammation shortly after injury. Hydrocortisone is also a glucocorticoid but is not mentioned in the statement as having any direct relation to sepsis mechanisms. + The statement discusses the results of a comparison between two non-steroidal anti-inflammatory drugs (NSAIDs), ketoprofen and ibuprofen, in terms of their effects on prostaglandin synthesis and gastroduodenal injury. Methylprednisolone is a corticosteroid and is not mentioned in the statement. - To establish indirect support for ""Hydrocortisone exacerbates Sepsis,"" there would need to be some connection between hydrocortisone use and increased sepsis risk or severity in either experimental results or prior literature discussed in context. Since neither is mentioned in the statement provided, it does not offer indirect support for that particular claim about hydrocortisone and sepsis." -8122784,Hydrocortisone exacerbates obesity disorder,479,"Combined treatments of rG-CSF with cefotaxime, cefazolin, fosfomycin, gentamicin or amphotericin B were evaluated in systemic infections with Pseudomonas aeruginosa, Escherichia coli, Serratia marcescens, Staphylococcus aureus and Candida albicans in leucopenic mice induced by pretreatment with cyclophosphamide.",False,"Is the triple 'Hydrocortisone exacerbates obesity disorder' supported by the sentence: 'Combined treatments of rG-CSF with cefotaxime, cefazolin, fosfomycin, gentamicin or amphotericin B were evaluated in systemic infections with Pseudomonas aeruginosa, Escherichia coli, Serratia marcescens, Staphylococcus aureus and Candida albicans in leucopenic mice induced by pretreatment with cyclophosphamide.'?","No, the statement does not provide indirect support for the phrase ""Hydrocortisone exacerbates obesity disorder"". The statement discusses the evaluation of combined treatments using various antibiotics and amphotericin B in systemic infections caused by several bacterial and fungal strains in leucopenic mice induced by cyclophosphamide pretreatment. There is no mention or implication of hydrocortisone, obesity, or any obesity-related disorders in the statement." -25411585,Hydrocortisone predisposes atrial fibrillation,480,"One such marker, CTX-M-15, expressed by Enterobacteriaceae produces beta-lactamases, which hydrolyze the cephalosporin group of antibiotics, such as cefotaxime, used in the treatment of both Gram-positive and negative bacterial infections.",False,"Is the triple 'Hydrocortisone predisposes atrial fibrillation' supported by the sentence: 'One such marker, CTX-M-15, expressed by Enterobacteriaceae produces beta-lactamases, which hydrolyze the cephalosporin group of antibiotics, such as cefotaxime, used in the treatment of both Gram-positive and negative bacterial infections.'?","No, the statement does not provide indirect support for the phrase ""Hydrocortisone predisposes atrial fibrillation."" The statement discusses the relationship between CTX-M-15 (a type of beta-lactamase) produced by Enterobacteriaceae and its ability to hydrolyze cephalosporin antibiotics like cefotaxime. This information is related to bacterial infections and antibiotic resistance rather than hydrocortisone and atrial fibrillation. + Corticosteroids like methylprednisolone are often used in spinal cord injury cases due to their anti-inflammatory effects, but the statement provided does not contain any information about methylprednisolone or its relation to spinal cord injury. Therefore, it does not indirectly support the phrase in question." +7944646,Methylprednisolone related to myasthenia gravis,32,The duration of action of sustained-release ibuprofen ('Brufen Retard') was investigated in a 14-day double-blind study involving 14 osteoarthritis and 10 rheumatoid arthritis patients.,False,"'Does the phrase ""Methylprednisolone related to myasthenia gravis"" receive at least indirect support from the statement: ""The duration of action of sustained-release ibuprofen ('Brufen Retard') was investigated in a 14-day double-blind study involving 14 osteoarthritis and 10 rheumatoid arthritis patients.""?","No, the statement does not provide indirect support for the phrase ""Methylprednisolone related to myasthenia gravis."" The study mentioned in the statement investigates the duration of action of sustained-release ibuprofen (Brufen Retard) in osteoarthritis and rheumatoid arthritis patients. Methylprednisolone is a corticosteroid used primarily for its anti-inflammatory effects in various conditions, while myasthenia gravis is an autoimmune neuromuscular disorder affecting the nervous system. There is no connection between methylprednisolone, myasthenia gravis, and the study on ibuprofen's duration of action." +7668599,Methylprednisolone related to multiple sclerosis,33,This study attempts to investigate the effect of ibuprofen on reducing eye pain and migraine headaches caused by trochleitis.,False,"'Does the phrase ""Methylprednisolone related to multiple sclerosis"" receive at least indirect support from the statement: ""This study attempts to investigate the effect of ibuprofen on reducing eye pain and migraine headaches caused by trochleitis.""?","No, the statement does not provide indirect support for the phrase ""Methylprednisolone related to multiple sclerosis"". The study mentioned investigates the effect of ibuprofen on reducing eye pain and migraine headaches caused by trochleitis. Methylprednisolone is not mentioned in the statement, nor is there any connection made to multiple sclerosis. Therefore, it is not possible to draw such a conclusion from this information alone." +7443745,Methylprednisolone related to asthma,34,"Ibuprofen suppresses the production of various pro-inflammatory cytokines that are implicated in the ""cytokine storm"" and subsequent ARDS in COVID-19 disease.",False,"'Does the phrase ""Methylprednisolone related to asthma"" receive at least indirect support from the statement: ""Ibuprofen suppresses the production of various pro-inflammatory cytokines that are implicated in the ""cytokine storm"" and subsequent ARDS in COVID-19 disease.""?","No, the statement does not provide indirect support for the phrase ""Methylprednisolone related to asthma"". The two statements discuss different medications (Ibuprofen vs Methylprednisolone) and different medical conditions (COVID-19 vs asthma). Ibuprofen's effect on cytokine production in COVID-19 does not imply any connection to Methylprednisolone's potential relation to asthma." +24973247,Methylprednisolone causes lupus nephritis,35,"After adjusting for covariates, the risk of BPD was associated independently with ibuprofen exposure (odds ratios (OR) 2.296, 95% confidence interval (CI): 1.166-4.522, p = 0.016).",False,"'Does the phrase ""Methylprednisolone causes lupus nephritis"" receive at least indirect support from the statement: ""After adjusting for covariates, the risk of BPD was associated independently with ibuprofen exposure (odds ratios (OR) 2.296, 95% confidence interval (CI): 1.166-4.522, p = 0.016).""?","No, the statement does not provide indirect support for the phrase ""Methylprednisolone causes lupus nephritis"". The statement discusses the association between ibuprofen exposure and bronchopulmonary dysplasia (BPD) risk in preterm infants. Methylprednisolone is not mentioned in this statement, nor is there any connection made between ibuprofen exposure, BPD risk, methylprednisolone use, and lupus nephritis development in the provided information. Therefore, it is inappropriate to draw such conclusions based on this statement alone without additional context or evidence linking these variables together." +24161886,Methylprednisolone causes Edema,36,The opposite effect of ibuprofen on ethanol-induced cognitive impairment as measured by two lateralized functions is consistent with the reports in tissue and animal models that central nervous system effects of ethanol may be mediated at least in part by prostaglandins.,False,"'Does the phrase ""Methylprednisolone causes Edema"" receive at least indirect support from the statement: ""The opposite effect of ibuprofen on ethanol-induced cognitive impairment as measured by two lateralized functions is consistent with the reports in tissue and animal models that central nervous system effects of ethanol may be mediated at least in part by prostaglandins.""?","No, the statement does not provide indirect support for the phrase ""Methylprednisolone causes Edema"". - Atrial fibrillation is an irregular heart rhythm (arrhythmia), while hydrocortisone is a type of steroid hormone often used in anti-inflammatory treatments. Although there may be various factors contributing to atrial fibrillation development, there is no clear connection between hydrocortisone usage and atrial fibrillation based on the provided statement. + The statement discusses the opposite effect of ibuprofen on ethanol-induced cognitive impairment and mentions that central nervous system effects of ethanol may be mediated by prostaglandins. Methylprednisolone is a corticosteroid drug used for its anti-inflammatory and immunosuppressive effects, while ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID). - To establish such indirect support, there would need to be some link between hydrocortisone usage and atrial fibrillation risk markers (such as CTX-M-15 in the statement) in the context presented; however, no" -19755964,Hydrocortisone predisposes Sepsis,481,"CONS, Staphylococcus aureus, Enterococci, Escherichia coli, Klebsiella and Enterobacter represented 91.9% of LOS episodes and were susceptible to vancomycin and cefotaxime (96.1%), vancomycin and gentamicin (97.0%) and cloxacillin and gentamicin (38.1%).",False,"Is the triple 'Hydrocortisone predisposes Sepsis' supported by the sentence: 'CONS, Staphylococcus aureus, Enterococci, Escherichia coli, Klebsiella and Enterobacter represented 91.9% of LOS episodes and were susceptible to vancomycin and cefotaxime (96.1%), vancomycin and gentamicin (97.0%) and cloxacillin and gentamicin (38.1%).'?","No, the statement does not provide indirect support for the phrase ""Hydrocortisone predisposes Sepsis."" The statement discusses antibiotic susceptibility patterns in certain bacterial species that frequently cause hospital-acquired infections (Los episodes). It does not mention hydrocortisone or sepsis at all. Sepsis is a complex condition that involves an overwhelming immune response to an infection, which can be caused by various microorganisms, not only those listed in the statement. Hydrocortisone is a glucocorticoid hormone that has anti-inflammatory effects and is sometimes used in treating sepsis; however, its use does not automatically predispose someone to sepsis as it has both beneficial and potentially harmful effects depending on the context in which it is used." -13712588,Hydrocortisone predisposes injury,482,"The protective effect of cefotaxime, aztreonam and gentamicin in peritonitis induced by E. coli alone or combined with B. fragilis was evaluated by analysing mortality at 24 and 48 h after bacterial inoculation and treating the animals with two doses of each antibiotic.",False,"Is the triple 'Hydrocortisone predisposes injury' supported by the sentence: 'The protective effect of cefotaxime, aztreonam and gentamicin in peritonitis induced by E. coli alone or combined with B. fragilis was evaluated by analysing mortality at 24 and 48 h after bacterial inoculation and treating the animals with two doses of each antibiotic.'?","No, the statement does not provide indirect support for the phrase ""Hydrocortisone predisposes injury."" The statement discusses an experiment where three antibiotics were tested for their protective effect against peritonitis induced by Escherichia coli (E. coli) alone or combined with Bacteroides fragilis in animals. There is no mention or implication of hydrocortisone in this experiment or its potential involvement in predisposing injury." -12555774,Hydrocortisone predisposes toxic shock syndrome,483,"HR 810 had more potent protective effect than ceftazidime (CAZ), cefoperazone (CPZ), and cefotaxime (CTX) on systemic infections induced by Escherichia coli Ec-31, Staphylococcus aureus SMITH, and Serratia marcescens Sm-6 in mice.",False,"Is the triple 'Hydrocortisone predisposes toxic shock syndrome' supported by the sentence: 'HR 810 had more potent protective effect than ceftazidime (CAZ), cefoperazone (CPZ), and cefotaxime (CTX) on systemic infections induced by Escherichia coli Ec-31, Staphylococcus aureus SMITH, and Serratia marcescens Sm-6 in mice.'?","No, the statement does not provide direct or indirect support for the phrase ""Hydrocortisone predisposes toxic shock syndrome."" The statement discusses the efficacy of various antibiotics in protecting mice from systemic infections caused by certain bacteria. Hydrocortisone is not mentioned in this statement, nor is there any information linking it to toxic shock syndrome. Therefore, it is not possible to make any conclusions about the relationship between hydrocortisone and toxic shock syndrome based on this statement alone." -11782928,Hydrocortisone predisposes Inflammation,484,"1,480 patients, undergoing elective orthopedic and traumatic surgery, received intragluteal injections of ceftriaxone (Rocephin) to prevent bacterial infections.",False,"Is the triple 'Hydrocortisone predisposes Inflammation' supported by the sentence: '1,480 patients, undergoing elective orthopedic and traumatic surgery, received intragluteal injections of ceftriaxone (Rocephin) to prevent bacterial infections.'?","No, the statement does not provide any direct or indirect support for the phrase ""Hydrocortisone predisposes Inflammation"". The statement mentions that patients received ceftriaxone (Rocephin) injections for preventing bacterial infections during surgery; however, it does not mention hydrocortisone or inflammation at all. To evaluate whether hydrocortisone predisposes inflammation, we would need evidence related specifically to hydrocortisone use and its impact on inflammation." -10520517,Hydrocortisone predisposes obesity disorder,485,Proceedings: A double blind trial of carbenoxolone and geranyl farnesylacetate in gastric ulcer.,False,Is the triple 'Hydrocortisone predisposes obesity disorder' supported by the sentence: 'Proceedings: A double blind trial of carbenoxolone and geranyl farnesylacetate in gastric ulcer.'?,"No, the statement ""Proceedings: A double blind trial of carbenoxolone and geranyl farnesylacetate in gastric ulcer"" does not provide indirect support for the phrase ""Hydrocortisone predisposes obesity disorder."" + Edema is swelling caused by excess fluid trapped in your body's tissues. Although both methylprednisolone and ibuprofen can have effects on inflammation, they have different mechanisms of action. Methylprednisolone reduces inflammation by suppressing the immune system, while ibuprofen inhibits cyclooxygenase (COX) enzymes, which produce prostaglandins—lipid compounds that trigger inflammation in response to injury or infection. - The statement is about a double-blind trial involving carbenoxolone and geranyl farnesylacetate in treating gastric ulcers. There is no mention or implication of hydrocortisone, obesity disorder, or any connection between them in this statement. Hydrocortisone is a steroid hormone often used in medication for various conditions such as inflammation, allergies, and skin disorders; it is not mentioned in the given statement. Therefore, it does not offer any indirect support for the claim about hydrocortisone predisposing obesity disorder." -8615556,Hydrocortisone predisposes dissociative amnesia,486,A controlled double-blind study was performed in 17 institutes using gefarnate as a control drug in order to investigate the therapeutic effect and safety of pirenzepine dihydrochloride (LS 519) in duodenal ulcer.,False,Is the triple 'Hydrocortisone predisposes dissociative amnesia' supported by the sentence: 'A controlled double-blind study was performed in 17 institutes using gefarnate as a control drug in order to investigate the therapeutic effect and safety of pirenzepine dihydrochloride (LS 519) in duodenal ulcer.'?,"No, the statement does not provide any direct or indirect support for the claim that ""Hydrocortisone predisposes dissociative amnesia."" The study mentioned is investigating the therapeutic effect and safety of pirenzepine dihydrochloride (LS 519) in duodenal ulcer using gefarnate as a control drug. Hydrocortisone is not mentioned in this statement, nor is there any information linking it to dissociative amnesia. Therefore, it is not appropriate to draw such conclusions based on this information alone." -8552834,Hydrocortisone predisposes asthma,487,Gefarnate at 300 mg/kg (p.o.) significantly inhibited phenylbutazone-induced gastric ulcers in rats but had no effect on other ulcer models.,False,Is the triple 'Hydrocortisone predisposes asthma' supported by the sentence: 'Gefarnate at 300 mg/kg (p.o.) significantly inhibited phenylbutazone-induced gastric ulcers in rats but had no effect on other ulcer models.'?,"No, the statement does not provide any indirect support for the phrase ""Hydrocortisone predisposes asthma."" The two statements discuss different subjects: one is about hydrocortisone potentially predisposing individuals to asthma, while the other is about gefarnate inhibiting phenylbutazone-induced gastric ulcers in rats without affecting other ulcer models. There is no overlap in content between these two statements that would allow for inferring support for the claim about hydrocortisone and asthma." -8002300,Hydrocortisone predisposes Insulin resistance,488,We tested streptomycin (ST) and neomycin (NEO) as analgesic agents applied in situ in rat paw inflammation caused by formalin or carrageenan administration.,False,Is the triple 'Hydrocortisone predisposes Insulin resistance' supported by the sentence: 'We tested streptomycin (ST) and neomycin (NEO) as analgesic agents applied in situ in rat paw inflammation caused by formalin or carrageenan administration.'?,"No, the statement does not provide any direct or indirect support for the phrase ""Hydrocortisone predisposes Insulin resistance"". The experiment tested streptomycin (ST) and neomycin (NEO) as analgesic agents in rat paw inflammation caused by formalin or carrageenan administration. There is no mention of hydrocortisone, insulin resistance, or any related conditions in the statement. Therefore, it is not possible to draw any conclusions about the relationship between hydrocortisone and insulin resistance based on this information alone." -7960726,Hydrocortisone predisposes pneumonia,489,[ON THE ACTION OF A NEOMYCIN AND THIOPENICOL PREPARATION IN EXPERIMENTAL BURNS].,False,Is the triple 'Hydrocortisone predisposes pneumonia' supported by the sentence: '[ON THE ACTION OF A NEOMYCIN AND THIOPENICOL PREPARATION IN EXPERIMENTAL BURNS].'?,"No, the statement ""Hydrocortisone predisposes pneumonia"" does not receive indirect support from the provided statement: ""[ON THE ACTION OF A NEOMYCIN AND THIOPENICOL PREPARATION IN EXPERIMENTAL BURNS]"". + The connection between methylprednisolone and ed" +18534953,Methylprednisolone causes Inflammation,37,"On post-partum day five, she began complaining of headaches, initially responsive to ibuprofen but eventually worsened with no relief.",False,"'Does the phrase ""Methylprednisolone causes Inflammation"" receive at least indirect support from the statement: ""On post-partum day five, she began complaining of headaches, initially responsive to ibuprofen but eventually worsened with no relief.""?","No, the phrase ""Methylprednisolone causes Inflammation"" does not receive at least indirect support from the statement provided. The statement discusses a patient who developed headaches on post-partum day five, which were initially responsive to ibuprofen but later worsened without relief. The use of methylprednisolone is not mentioned in the statement, nor is there any indication that inflammation was present or caused by any specific agent. Therefore, it is not possible to infer any relationship between methylprednisolone use and inflammation from this statement alone." +18260665,Methylprednisolone causes neoplasm,38,"Because ibuprofen protects from septic lung injury, we studied the effect of ibuprofen in oxidant lung injury from phosgene.",False,"'Does the phrase ""Methylprednisolone causes neoplasm"" receive at least indirect support from the statement: ""Because ibuprofen protects from septic lung injury, we studied the effect of ibuprofen in oxidant lung injury from phosgene.""?","No, the statement does not provide indirect support for the phrase ""Methylprednisolone causes neoplasm."" The two statements discuss different drugs (ibuprofen and methylprednisolone) and different conditions (septic lung injury from bacterial infection versus neoplasm, which is abnormal growth of cells in the body that can lead to cancer). Therefore, there is no logical connection between them that would allow us to infer a causal relationship between methylprednisolone and neoplasm based on the provided statement about ibuprofen and lung injury from phosgene exposure." +17307095,Methylprednisolone causes pneumonia,39,The efficacy and tolerance of ibuprofen retard at a dose of 2 x 800 mg daily was investigated in an open multicenter study over a period of 3 weeks on 7931 out-patients with activated degenerative joint disease and/or extraarticular rheumatic symptoms.,False,"'Does the phrase ""Methylprednisolone causes pneumonia"" receive at least indirect support from the statement: ""The efficacy and tolerance of ibuprofen retard at a dose of 2 x 800 mg daily was investigated in an open multicenter study over a period of 3 weeks on 7931 out-patients with activated degenerative joint disease and/or extraarticular rheumatic symptoms.""?","No, the statement does not provide indirect support for the phrase ""Methylprednisolone causes pneumonia."" The statement discusses a study investigating the efficacy and tolerance of ibuprofen at specific doses in out-patients with activated degenerative joint disease and/or extraarticular rheumatic symptoms over three weeks. It does not mention Methylprednisolone nor pneumonia; therefore, it does not contribute any relevant evidence towards that claim." +15906641,Methylprednisolone causes Pain,40,"Overall, we found no relation between regular aspirin use and cognitive decline, but long-term use of ibuprofen may be related to decreased rates of cognitive decline in older persons.",False,"'Does the phrase ""Methylprednisolone causes Pain"" receive at least indirect support from the statement: ""Overall, we found no relation between regular aspirin use and cognitive decline, but long-term use of ibuprofen may be related to decreased rates of cognitive decline in older persons.""?","No, the statement does not provide indirect support for the phrase ""Methylprednisolone causes Pain"". The statement discusses the relationship between regular aspirin use, ibuprofen use, and cognitive decline in older persons, without mentioning methylprednisolone or pain at all. Methylprednisolone is a corticosteroid medication used primarily for its anti-inflammatory effects in various conditions such as arthritis, asthma, blood disorders, allergic reactions, and certain skin disorders. Pain is not explicitly mentioned in either the claim or the statement provided. Therefore, there is no basis for drawing any connection between them based on the information given." +13166073,Methylprednisolone causes thrombocytopenia,41,"Subdiaphragmatic vagotomy or 7-nitroindazole reduced, icatibant, DALBK, IL-1ra, aminoguanidine and dipyrone abolished, while ibuprofen and celecoxib failed to affect Tsv-induced fever.",False,"'Does the phrase ""Methylprednisolone causes thrombocytopenia"" receive at least indirect support from the statement: ""Subdiaphragmatic vagotomy or 7-nitroindazole reduced, icatibant, DALBK, IL-1ra, aminoguanidine and dipyrone abolished, while ibuprofen and celecoxib failed to affect Tsv-induced fever.""?","No, the statement does not provide indirect support for the phrase ""Methylprednisolone causes thrombocytopenia."" The statement discusses various substances and their effects on Tsv-induced fever, but none of these substances include Methylprednisolone, nor does it mention thrombocytopenia (a condition characterized by decreased platelet count). Therefore, there is no connection that can be inferred between Methylprednisolone and thrombocytopenia based on this statement." +12672767,Methylprednisolone causes drug-induced liver injury,42,Reduced incidence of gastroduodenal ulcers associated with lumiracoxib compared with ibuprofen in patients with rheumatoid arthritis.,False,"'Does the phrase ""Methylprednisolone causes drug-induced liver injury"" receive at least indirect support from the statement: ""Reduced incidence of gastroduodenal ulcers associated with lumiracoxib compared with ibuprofen in patients with rheumatoid arthritis.""?","No, the statement does not provide indirect support for the phrase ""Methylprednisolone causes drug-induced liver injury."" The statement discusses the reduced incidence of gastroduodenal ulcers associated with lumiracoxib compared to ibuprofen in patients with rheumatoid arthritis. This information is not related to methylprednisolone nor drug-induced liver injury; therefore, it does not offer any indirect support for the claim in question. - The provided statement is about an experimental study on burns using a neomycin and thiopencil preparation, which does not mention hydrocortisone or pneumonia at all. Indirect support would require some connection between the two pieces of information, but in this case, there is no such connection. Therefore, it is not appropriate to infer that hydrocortisone predisposes pneumonia based on this statement alone." -27228384,Methylprednisolone related to Crohn disease,490,"Therefore, we investigated the effect of long-term exposure of an antibiotic cocktail composed of Vancomycin, Neomycin, and Streptomycin, on tumor development and progression in the ApcMin/+ mouse, an established genetic model for familial adenomatous polyposis.",False,"Is the triple 'Methylprednisolone related to Crohn disease' supported by the sentence: 'Therefore, we investigated the effect of long-term exposure of an antibiotic cocktail composed of Vancomycin, Neomycin, and Streptomycin, on tumor development and progression in the ApcMin/+ mouse, an established genetic model for familial adenomatous polyposis.'?","No, the statement does not provide indirect support for the phrase ""Methylprednisolone related to Crohn disease."" The statement discusses an investigation into the effect of long-term exposure to an antibiotic cocktail on tumor development and progression in a specific mouse model for familial adenomatous polyposis. Methylprednisolone is a corticosteroid used primarily for its anti-inflammatory effects in various diseases such as Crohn disease; however, it is not mentioned nor implied in the provided statement. Therefore, it is not reasonable to infer any connection between methylprednisolone and Crohn disease based on this information alone." -26974005,Methylprednisolone related to hematopoietic and lymphoid system neoplasm,491,Ultrahigh doses of gentamicin and clinically relevant doses of neomycin affect inflammation and angiogenesis in in vivo and in vitro models.,False,Is the triple 'Methylprednisolone related to hematopoietic and lymphoid system neoplasm' supported by the sentence: 'Ultrahigh doses of gentamicin and clinically relevant doses of neomycin affect inflammation and angiogenesis in in vivo and in vitro models.'?,"No, the statement does not provide indirect support for the phrase ""Methylprednisolone related to hematopoietic and lymphoid system neoplasm."" The statement discusses the effects of ultrahigh doses of gentamicin and clinically relevant doses of neomycin on inflammation and angiogenesis in in vivo and in vitro models. Methylprednisolone is not mentioned in the statement, nor is there any connection made between these antibiotics and hematopoietic and lymphoid system neoplasms (a type of cancer). Therefore, it is not possible to infer any relationship between methylprednisolone and hematopoietic and lymphoid system neoplasms based on this information alone." -26513818,Methylprednisolone related to B-cell chronic lymphocytic leukemia,492,"Biodegradable polyaspartamide (PASPAM) was grafted with several functional groups to implement diverse roles-octadecylamine (C 18 ) for nano-aggregate formation, dopamine (DOPA) for adhesive function, neomycin (NEO) for inhibition of bacterial infection.",False,"Is the triple 'Methylprednisolone related to B-cell chronic lymphocytic leukemia' supported by the sentence: 'Biodegradable polyaspartamide (PASPAM) was grafted with several functional groups to implement diverse roles-octadecylamine (C 18 ) for nano-aggregate formation, dopamine (DOPA) for adhesive function, neomycin (NEO) for inhibition of bacterial infection.'?","No, there is no direct or indirect support for the phrase ""Methylprednisolone related to B-cell chronic lymphocytic leukemia"" in the statement provided. The statement discusses the grafting of functional groups onto biodegradable polyaspartamide (PASPAM) for various roles, but it does not mention methylprednisolone or B-cell chronic lymphocytic leukemia at all. Methylprednisolone is a corticosteroid medication used for various conditions like allergies, arthritis, and other inflammatory diseases; it is not mentioned in the context of B-cell chronic lymphocytic leukemia in this statement." -26050805,Methylprednisolone related to ankylosing spondylitis,493,Kaposi's sarcoma-associated herpesvirus-positive primary effusion lymphoma tumor formation in NOD/SCID mice is inhibited by neomycin and neamine blocking angiogenin's nuclear translocation.,False,Is the triple 'Methylprednisolone related to ankylosing spondylitis' supported by the sentence: 'Kaposi's sarcoma-associated herpesvirus-positive primary effusion lymphoma tumor formation in NOD/SCID mice is inhibited by neomycin and neamine blocking angiogenin's nuclear translocation.'?,"No, the statement does not provide indirect support for the phrase ""Methylprednisolone related to ankylosing spondylitis."" The statement discusses Kaposi's sarcoma-associated herpesvirus-positive primary effusion lymphoma tumor formation in NOD/SCID mice and its inhibition by neomycin and neamine blocking angiogenin's nuclear translocation. There is no mention or implication of methylprednisolone or ankylosing spondylitis in the statement. Methylprednisolone is a corticosteroid used for its anti-inflammatory effects, while ankylosing spondylitis is a type of arthritis affecting the spine; neither is related to the Kaposi's sarcoma-associated herpesvirus or angiogenin mentioned in the statement." -25845844,Methylprednisolone related to breast neoplasm,494,Neomycin and the combination of neomycin and bacitracin in the prevention of bacterial infection in surgery of the colon and/or rectum.,False,Is the triple 'Methylprednisolone related to breast neoplasm' supported by the sentence: 'Neomycin and the combination of neomycin and bacitracin in the prevention of bacterial infection in surgery of the colon and/or rectum.'?,"No, the statement does not provide indirect support for the phrase ""Methylprednisolone related to breast neoplasm."" The two statements discuss different topics: one is about antibiotics (neomycin and bacitracin) used in surgery for colon/rectum infections, while the other is about Methylprednisolone potentially being related to breast neoplasm (tumor). There is no connection between these two ideas in terms of content, context, or implied relationships." -25642837,Methylprednisolone related to dermatomyositis,495,Results of salvage therapy with mini-hyper-CVD and inotuzumab ozogamicin with or without blinatumomab in pre-B acute lymphoblastic leukemia.,False,Is the triple 'Methylprednisolone related to dermatomyositis' supported by the sentence: 'Results of salvage therapy with mini-hyper-CVD and inotuzumab ozogamicin with or without blinatumomab in pre-B acute lymphoblastic leukemia.'?,"No, the statement does not provide any direct or indirect support for the phrase ""Methylprednisolone related to dermatomyositis."" The statement discusses salvage therapy for pre-B acute lymphoblastic leukemia using mini-hyper-CVD, inotuzumab ozogamicin, and blinatumomab, but it does not mention methylprednisolone or dermatomyositis. Therefore, there is no connection that can be inferred from this statement." -25328503,Methylprednisolone related to Meniere disease,496,"The impressive clinical success of the continuously intravenously infused T cell-redirecting bispecific antibody (T-bsAb) blinatumomab (anti-CD19 x anti-CD3), and of engineered T cells expressing anti-CD19 chimeric antigen receptors (CAR-T cells) in hematological malignancies, has led to renewed interest in a novel cancer immunotherapy strategy that combines features of antibody- and cell-based therapies.",False,"Is the triple 'Methylprednisolone related to Meniere disease' supported by the sentence: 'The impressive clinical success of the continuously intravenously infused T cell-redirecting bispecific antibody (T-bsAb) blinatumomab (anti-CD19 x anti-CD3), and of engineered T cells expressing anti-CD19 chimeric antigen receptors (CAR-T cells) in hematological malignancies, has led to renewed interest in a novel cancer immunotherapy strategy that combines features of antibody- and cell-based therapies.'?","No, the statement does not provide indirect support for the phrase ""Methylprednisolone related to Meniere disease."" The statement discusses advancements in cancer immunotherapy using T cell-redirecting bispecific antibodies (T-bsAb) and chimeric antigen receptor (CAR) T cells in hematological malignancies, but it does not mention Methylprednisolone nor Meniere disease. Methylprednisolone is a corticosteroid commonly used for its anti-inflammatory effects in various conditions, while Meniere disease is an inner ear disorder characterized by vertigo, tinnitus, hearing loss, and pressure in the affected ear. Although both Methylprednisolone and cancer immunotherapy can be relevant in treating certain medical conditions, they are not inherently related in this context." -24759961,Methylprednisolone related to non-Hodgkin lymphoma,497,Blinatumomab and inotuzumab ozogamycin represent promising alternatives to conventional chemotherapy in acute lymphoblastic leukaemia (ALL).,False,Is the triple 'Methylprednisolone related to non-Hodgkin lymphoma' supported by the sentence: 'Blinatumomab and inotuzumab ozogamycin represent promising alternatives to conventional chemotherapy in acute lymphoblastic leukaemia (ALL).'?,"No, the statement ""Blinatumomab and inotuzumab ozogamycin represent promising alternatives to conventional chemotherapy in acute lymphoblastic leukaemia (ALL)"" does not provide indirect support for the phrase ""Methylprednisolone related to non-Hodgkin lymphoma."" + To further elaborate on the reasons for my answer, let us examine the components of the given statement more closely: - The statement discusses two promising treatments for acute lymphoblastic leukaemia (ALL), blinatumomab and inotuzumab ozogamycin, as alternatives to conventional chemotherapy. Methylprednisolone is not mentioned in this statement nor is it implied in any way as being related to non-Hodgkin lymphoma. + 1. Reduced incidence of gastroduodenal ulcers + 2. Associated with lumiracoxib compared with ibuprofen + 3. In patients with rheumatoid arthritis - Non-Hodgkin lymphoma is a type of cancer that starts in white blood cells called lymphocytes, which are part of the body's immune system. It is distinct from acute lymphoblastic leukaemia (ALL), which is a rapidly progressing cancer that starts from early forms of white blood cells in bone marrow called lymphoblasts. + As we can see from these components, there is no mention of methylprednisolone nor any reference to drug-induced liver injury in general. The focus of the statement is on lumiracoxib versus ibuprofen regarding gastroduodenal ulcers in rheumatoid arthritis patients." +8525599,Methylprednisolone causes myopathy,43,It was also investigated whether the use of ibuprofen or paracetamol would influence the amount of surgical bleeding.,False,"'Does the phrase ""Methylprednisolone causes myopathy"" receive at least indirect support from the statement: ""It was also investigated whether the use of ibuprofen or paracetamol would influence the amount of surgical bleeding.""?","No, the statement does not provide indirect support for the phrase ""Methylprednisolone causes myopathy."" - Methyl" -24691450,Methylprednisolone related to plantar fasciitis,498,Efficacy of ciprofloxacin and dexamethasone in experimental pseudomonas endophthalmitis.,False,Is the triple 'Methylprednisolone related to plantar fasciitis' supported by the sentence: 'Efficacy of ciprofloxacin and dexamethasone in experimental pseudomonas endophthalmitis.'?,"No, the statement ""Efficacy of ciprofloxacin and dexamethasone in experimental pseudomonas endophthalmitis"" does not provide indirect support for the phrase ""Methylprednisolone related to plantar fasciitis."" The statement discusses the efficacy of ciprofloxacin and dexamethasone in treating experimental pseudomonas endophthalmitis, an eye condition. Methylprednisolone is not mentioned in the statement nor is it related to ciprofloxacin, dexamethasone, or pseudomonas endophthalmitis in any way that would suggest an indirect link to plantar fasciitis. + The statement ""It was also investigated whether the use of ibuprofen or paracetamol would influence the amount of surgical bleeding"" is related to the use of non-steroidal anti-inflammatory drugs (NSAIDs) like ibuprofen and paracetamol in managing surgical bleeding. This is unrelated to Methylprednisolone, which is a corticosteroid often used for its anti-inflammatory and immunosuppressive effects. - Plantar fasciitis is a foot condition that involves inflammation of the plantar fascia tissue, while methylprednisolone is a type of corticosteroid used for its anti-inflammatory properties in various medical conditions. The lack of any direct or indirect connection between methylprednisolone and plantar fasciitis in the provided statement necessitates a negative response to the question." -24586108,Methylprednisolone related to alcoholic hepatitis,499,CONCLUSIONS: Combination therapy of adalimumab and ciprofloxacin is more effective than adalimumab monotherapy to achieve fistula closure in CD.,False,Is the triple 'Methylprednisolone related to alcoholic hepatitis' supported by the sentence: 'CONCLUSIONS: Combination therapy of adalimumab and ciprofloxacin is more effective than adalimumab monotherapy to achieve fistula closure in CD.'?,"No, the statement does not provide any direct or indirect support for the connection between methylprednisolone and alcoholic hepatitis. The conclusion is about the efficacy of combination therapy (adalimumab and ciprofloxacin) versus adalimumab monotherapy in achieving fistula closure in Crohn's disease (CD). There is no mention or implication of methylprednisolone or alcoholic hepatitis in this statement." -24559507,Methylprednisolone related to respiratory system disorder,500,"Tested substances displayed inhibitory effect towards E. coli DNA gyrase, though less than ciprofloxacin.",False,"Is the triple 'Methylprednisolone related to respiratory system disorder' supported by the sentence: 'Tested substances displayed inhibitory effect towards E. coli DNA gyrase, though less than ciprofloxacin.'?","No, the statement does not provide indirect support for the phrase ""Methylprednisolone related to respiratory system disorder"". The statement discusses tested substances displaying an inhibitory effect towards Escherichia coli (E. coli) DNA gyrase, which is an enzyme involved in bacterial DNA replication. Methylprednisolone is a corticosteroid hormone medication used primarily for its anti-inflammatory effects in various conditions such as allergies, arthritis, and autoimmune disorders. It has no direct relation to E. coli DNA gyrase or respiratory system disorders." -23573980,Methylprednisolone related to pneumonia,1,Evaluation of granulated fenbendazole (22.2%) against induced and naturally occurring helminth infections in cats.,False,Is the triple 'Methylprednisolone related to pneumonia' supported by the sentence: 'Evaluation of granulated fenbendazole (22.2%) against induced and naturally occurring helminth infections in cats.'?,"No, the statement ""Evaluation of granulated fenbendazole (22.2%) against induced and naturally occurring helminth infections in cats"" does not provide indirect support for the phrase ""Methylprednisolone related to pneumonia."" The statement discusses an evaluation of fenbendazole, an anthelmintic drug used for treating parasitic worm infections in cats, against naturally occurring helminth infections. Methylprednisolone is a corticosteroid used for its anti-inflammatory effects in various conditions; it is unrelated to fenbendazole or helminth infections in cats. Therefore, there is no connection between these two pieces of information that would support methylprednisolone being related to pneumonia." -23514846,Methylprednisolone related to carpal tunnel syndrome,2,Fenbendazole resistance in O. ostertagi was confirmed with a total treatment failure in reducing worm burden: efficacy of 0%.,False,Is the triple 'Methylprednisolone related to carpal tunnel syndrome' supported by the sentence: 'Fenbendazole resistance in O. ostertagi was confirmed with a total treatment failure in reducing worm burden: efficacy of 0%.'?,"No, the statement does not provide indirect support for the phrase ""Methylprednisolone related to carpal tunnel syndrome."" The two statements discuss unrelated subjects: one about fenbendazole resistance in O. ostertagi (a type of parasitic worm affecting cattle) and its treatment efficacy, while the other connects methylprednisolone (a corticosteroid medication) to carpal tunnel syndrome (a medical condition affecting the wrist). + Myopathy can be a side effect of long-term use of corticosteroids like Methylprednisolone. However, the statement provided does not contain any information about Methylprednisolone, its usage, or its side effects. Therefore, it does not provide any indirect support for the claim that Methylprednisolone causes myopathy." +27357949,Methylprednisolone affects neoplasm,44,"In a randomised, placebo-controlled, double-blind trial of prophylaxis with ibuprofen, the rate of patent ductus arteriosus associated with ibuprofen was 19% compared with 42% with placebo.",False,"'Does the phrase ""Methylprednisolone affects neoplasm"" receive at least indirect support from the statement: ""In a randomised, placebo-controlled, double-blind trial of prophylaxis with ibuprofen, the rate of patent ductus arteriosus associated with ibuprofen was 19% compared with 42% with placebo.""?","No, the statement does not provide indirect support for the phrase ""Methylprednisolone affects neoplasm"". - The connection between methylprednisolone and carpal tunnel syndrome is not mentioned nor implied in any way in the statement about fenbendazole resistance in O. ostertagi. To establish indirect support for such a connection, there should be some commonality between the subjects discussed in both statements, which is absent in this case." -23364897,Methylprednisolone related to West syndrome,3,Symptoms of perianal itching and visualization of visible motile worms persisted for 6 months despite being treated with multiple courses of albendazole causing a lot of frustration and distress to the caregivers.,False,Is the triple 'Methylprednisolone related to West syndrome' supported by the sentence: 'Symptoms of perianal itching and visualization of visible motile worms persisted for 6 months despite being treated with multiple courses of albendazole causing a lot of frustration and distress to the caregivers.'?,"No, the phrase ""Methylprednisolone related to West syndrome"" does not receive indirect support from the statement provided. The statement discusses a patient being treated for symptoms related to perianal itching and visible motile worms that persisted for 6 months despite multiple courses of albendazole treatment. This situation is not related to Methylprednisolone usage nor West syndrome, which is a severe form of childhood epilepsy characterized by infantile spasms, hypsarrhythmia on EEG, and psychomotor retardation. Therefore, there is no connection between the statement and Methylprednisolone being related to West syndrome." -22495910,Methylprednisolone related to myocarditis,4,"Ovicidal effects of albendazole in human ascariasis, ancylostomiasis and trichuriasis.",False,"Is the triple 'Methylprednisolone related to myocarditis' supported by the sentence: 'Ovicidal effects of albendazole in human ascariasis, ancylostomiasis and trichuriasis.'?","No, the statement ""Ovicidal effects of albendazole in human ascariasis, ancylostomiasis and trichuriasis"" does not provide indirect support for the phrase ""Methylprednisolone related to myocarditis."" The two statements discuss different topics: one is about the ovicidal effects (the ability to kill the eggs) of albendazole on certain parasites in humans (ascariasis, ancylostomiasis, trichuriasis), while the other is about methylprednisolone potentially being associated with myocarditis (inflammation of heart muscle). To establish indirect support between these two statements, there should be some common ground in terms of shared concepts, mechanisms, or contexts that would allow for inferential reasoning; however, no such link is apparent here." -22175056,Methylprednisolone related to myopathy,5,"A combination of drugs Ivermectin, Diethylcarbamazine citrate and Albendazole is recommended by WHO to accelerate the Global Programme to Eliminate Lymphatic Filariasis (GPELF).",False,"Is the triple 'Methylprednisolone related to myopathy' supported by the sentence: 'A combination of drugs Ivermectin, Diethylcarbamazine citrate and Albendazole is recommended by WHO to accelerate the Global Programme to Eliminate Lymphatic Filariasis (GPELF).'?","No, the statement does not provide indirect support for the phrase ""Methylprednisolone related to myopathy"". The two statements discuss different topics: one is about a recommended treatment for lymphatic filariasis by the World Health Organization (WHO), while the other refers to a potential side effect of a specific drug called Methylprednisolone. There is no connection between these two ideas in the provided statement." -20879022,Methylprednisolone related to Pain,6,Effect of albendazole in experimental toxocariasis of mice.,False,Is the triple 'Methylprednisolone related to Pain' supported by the sentence: 'Effect of albendazole in experimental toxocariasis of mice.'?,"No, the statement ""Effect of albendazole in experimental toxocariasis of mice"" does not provide any direct or indirect support for the phrase ""Methylprednisolone related to Pain"". The two statements discuss different subjects: one is about the effects of an anthelmintic drug (albendazole) on experimental toxocariasis in mice, while the other refers to methylprednisolone's potential relationship with pain. To establish support for the connection between methylprednisolone and pain, one would need evidence specifically pertaining to that relationship." -20342058,Methylprednisolone related to chronic progressive multiple sclerosis,7,"Given the low helminth prevalence in our children, the effect of albendazole on malaria is likely to be direct.",False,"Is the triple 'Methylprednisolone related to chronic progressive multiple sclerosis' supported by the sentence: 'Given the low helminth prevalence in our children, the effect of albendazole on malaria is likely to be direct.'?","No, there is no direct or indirect support for the phrase ""Methylprednisolone related to chronic progressive multiple sclerosis"" in the statement ""Given the low helminth prevalence in our children, the effect of albendazole on malaria is likely to be direct."" + The statement is about a clinical trial of prophylaxis with ibuprofen versus placebo for patent ductus arteriosus in newborns. It does not mention methylprednisolone, nor does it provide any information about neoplasms (tumors). Therefore, it does not offer any indirect evidence regarding the effect of methylprednisolone on neoplasms. - The statement concerns the relationship between helminth prevalence, albendazole (an anti-parasitic drug), and malaria in children. The argument is that since helminth prevalence is low, albendazole is likely to have a direct effect on malaria rather than an indirect effect through helminth control. + Methylprednisolone is a corticosteroid often used in clinical settings for its anti-inflammatory effects, while neoplasms refer to new and abnormal growths of tissue, often referred to as tumors. While both methylprednisolone and neoplasms can be subjects of medical research, the provided statement does not make any connection between them." +24420470,Methylprednisolone affects Inflammation,45,"The purpose of this study was to examine the effects of ibuprofen on delayed onset muscle soreness (DOMS), indirect markers of muscle damage and muscular performance.",False,"'Does the phrase ""Methylprednisolone affects Inflammation"" receive at least indirect support from the statement: ""The purpose of this study was to examine the effects of ibuprofen on delayed onset muscle soreness (DOMS), indirect markers of muscle damage and muscular performance.""?","No, the statement does not provide indirect support for the phrase ""Methylprednisolone affects Inflammation."" The study in question focuses on ibuprofen, another anti-inflammatory drug, but it does not mention Methylprednisolone nor does it provide any information about its effects on inflammation. Methylprednisolone is a corticosteroid often used for its potent anti-inflammatory properties; however, without specific evidence linking it to inflammation in the context of this study, there is no basis for such an inference." +23472756,Methylprednisolone affects Inflammation,46,CONCLUSIONS: Pretreatment with ibuprofen before elective total hip surgery increases the perioperative blood loss significantly.,False,"'Does the phrase ""Methylprednisolone affects Inflammation"" receive at least indirect support from the statement: ""CONCLUSIONS: Pretreatment with ibuprofen before elective total hip surgery increases the perioperative blood loss significantly.""?","No, the statement does not provide indirect support for the phrase ""Methylprednisolone affects Inflammation"". The conclusion in the statement is about the effect of ibuprofen on perioperative blood loss in elective total hip surgery, not about Methylprednisolone or its influence on inflammation." +20530617,Methylprednisolone affects systemic sclerosis,47,"The data suggest that nimesulide and ibuprofen, in addition to their anti-inflammatory and analgesic benefits, may also have a protective effect in osteoarthritis through the inhibition of apoptosis in chondrocytes.",False,"'Does the phrase ""Methylprednisolone affects systemic sclerosis"" receive at least indirect support from the statement: ""The data suggest that nimesulide and ibuprofen, in addition to their anti-inflammatory and analgesic benefits, may also have a protective effect in osteoarthritis through the inhibition of apoptosis in chondrocytes.""?","No, the statement does not provide indirect support for the phrase ""Methylprednisolone affects systemic sclerosis."" The statement discusses the potential protective effects of two non-steroidal anti-inflammatory drugs (NSAIDs), nimesulide and ibuprofen, on osteoarthritis through inhibition of apoptosis in chondrocytes. Methylprednisolone is a corticosteroid with anti-inflammatory properties but has no direct relation to systemic sclerosis in the statement provided. - Methylprednisolone is a corticosteroid used primarily for its anti-inflammatory effects in conditions such as asthma, rheumatoid arthritis, and multiple sclerosis flare-ups. Chronic progressive multiple sclerosis is a specific form of multiple sclerosis characterized by steady worsening over time without distinct relapses or remissions. + Systemic sclerosis is an autoimmune disease characterized by fibrosis in multiple organs, vasculopathy, and immune system dysfunction. While methylprednisolone can be used as an off-label treatment due to its anti-inflammatory properties, there is no direct evidence presented in the statement that connects methylprednisolone specifically to systemic sclerosis. The two NSAIDs mentioned in the statement have not been established as effective treatments for systemic sclerosis either; hence there is no indirect support for methylprednisolone affecting systemic s" +20254789,Methylprednisolone affects adult acute respiratory distress syndrome,48,Pretreatment with ibuprofen blocked the fever induced by RANTES.,False,"'Does the phrase ""Methylprednisolone affects adult acute respiratory distress syndrome"" receive at least indirect support from the statement: ""Pretreatment with ibuprofen blocked the fever induced by RANTES.""?","No, the statement ""Pretreatment with ibuprofen blocked the fever induced by RANTES"" does not provide indirect support for the claim that ""Methylprednisolone affects adult acute respiratory distress syndrome"". - The two subjects—albendazole/malaria/helminths and Methyl" -20290784,Methylprednisolone related to membranous glomerulonephritis,8,"Mass co-administration of ivermectin and albendazole by the LFEP had a significant effect on STH, which was further amplified by treatment with praziquantel and albendazole 4 months later.",False,"Is the triple 'Methylprednisolone related to membranous glomerulonephritis' supported by the sentence: 'Mass co-administration of ivermectin and albendazole by the LFEP had a significant effect on STH, which was further amplified by treatment with praziquantel and albendazole 4 months later.'?","No, the statement does not provide indirect support for the phrase ""Methylprednisolone related to membranous glomerulonephritis."" The statement discusses the impact of co-administering ivermectin and albendazole by the LFEP on Strongyloides stercoralis (STH), which was later amplified by treatment with praziquantel and albendazole. There is no mention or implication of methylprednisolone or membranous glomerulonephritis in this context." -20286711,Methylprednisolone related to neuromyelitis optica,9,The effect of single dose ivermectin alone or in combination with albendazole on Wuchereria bancrofti infection in primary school children in Tanzania.,False,Is the triple 'Methylprednisolone related to neuromyelitis optica' supported by the sentence: 'The effect of single dose ivermectin alone or in combination with albendazole on Wuchereria bancrofti infection in primary school children in Tanzania.'?,"No, the statement does not provide any direct or indirect support for the phrase ""Methylprednisolone related to neuromyelitis optica."" The study mentioned investigates the effect of ivermectin alone or in combination with albendazole on Wuchereria bancrofti infection in primary school children in Tanzania. This study does not involve methylprednisolone or discuss neuromyelitis optica; thus, it does not provide any relevant information or support for the given phrase." -19340184,Methylprednisolone related to chronic obstructive pulmonary disease,10,"Additionally, compared with albendazole, it resulted in a significant reduction in adult worm and total larval counts; moreover, it caused a decrease in the number of larvae deposited in muscles, with a highly significant decrease in the inflammatory cell infiltrate around the larvae and a considerable decrease in the expression of the angiogenic marker vascular endothelial growth factor in muscles.",False,"Is the triple 'Methylprednisolone related to chronic obstructive pulmonary disease' supported by the sentence: 'Additionally, compared with albendazole, it resulted in a significant reduction in adult worm and total larval counts; moreover, it caused a decrease in the number of larvae deposited in muscles, with a highly significant decrease in the inflammatory cell infiltrate around the larvae and a considerable decrease in the expression of the angiogenic marker vascular endothelial growth factor in muscles.'?","No, the statement does not provide indirect support for the phrase ""Methylprednisolone related to chronic obstructive pulmonary disease."" The statement discusses the effects of Methylprednisolone on adult worm and total larval counts, larvae deposition in muscles, inflammatory cell infiltrate around larvae, and vascular endothelial growth factor expression in muscles; however, it does not mention nor imply any connection between Methylprednisolone and chronic obstructive pulmonary disease (COPD). + The two statements discuss different therapeutic interventions (ibuprofen vs methylprednisolone) for different conditions (fever induced by RANTES vs adult acute respiratory distress syndrome). The mechanism by which ibuprofen blocks fever is through inhibition of cyclooxygenase (COX), thereby preventing prostaglandin synthesis in the hypothalamus; however, this mechanism is unrelated to methylprednisolone's potential effects on adult acute respiratory distress syndrome (ARDS). - The two concepts—Methylprednisolone and COPD—are unrelated in the provided context. Methylprednisolone is a corticosteroid used primarily for its anti-inflammatory effects in various conditions such as allergies, asthma, arthritis, and autoimmune diseases. Chronic obstructive pulmonary disease (COPD), on the other hand, is characterized by progressive airflow limitation due to chronic bronchitis, emphysema, or both. + Methylprednisolone is a corticosteroid that has been investigated for its potential anti-inflammatory effects in ARDS; however, its efficacy remains controversial in clinical practice due to concerns about immunosuppression leading to secondary infections and other complications in critically ill patients. - Although Methylprednisolone could potentially be used off-label in some" -18938435,Methylprednisolone related to graft versus host disease,11,"Quarterly albendazole during childhood was associated with reduced incidence of clinical malaria (HR 0.85 (95% CI 0.73-0.98), p = 0.03).",False,"Is the triple 'Methylprednisolone related to graft versus host disease' supported by the sentence: 'Quarterly albendazole during childhood was associated with reduced incidence of clinical malaria (HR 0.85 (95% CI 0.73-0.98), p = 0.03).'?","No, the statement does not provide indirect support for the phrase ""Methylprednisolone related to graft versus host disease"". The statement discusses the association between quarterly albendazole during childhood and reduced incidence of clinical malaria. This has no direct or indirect relation to methylprednisolone or graft versus host disease." -17333962,Methylprednisolone related to Inflammation,12,CONCLUSIONS: Mebendazole and albendazole showed reduced efficacy against Ascaris lumbricoides and hookworm infections at the recommended doses.,False,Is the triple 'Methylprednisolone related to Inflammation' supported by the sentence: 'CONCLUSIONS: Mebendazole and albendazole showed reduced efficacy against Ascaris lumbricoides and hookworm infections at the recommended doses.'?,"No, the statement does not provide indirect support for the phrase ""Methylprednisolone related to Inflammation."" The conclusion in the statement is about the reduced efficacy of two drugs, mebendazole and albendazole, against certain parasitic infections. This has no direct or indirect connection to methylprednisolone or inflammation. Methylprednisolone is a corticosteroid often used to reduce inflammation, but there is no mention of it in the given statement." -17288506,Methylprednisolone related to autoimmune thrombocytopenic purpura,13,Evaluation of effectiveness of diethylcarbamazine/albendazole combination in reduction of Wuchereria bancrofti infection using multiple infection parameters.,False,Is the triple 'Methylprednisolone related to autoimmune thrombocytopenic purpura' supported by the sentence: 'Evaluation of effectiveness of diethylcarbamazine/albendazole combination in reduction of Wuchereria bancrofti infection using multiple infection parameters.'?,"No, the statement ""Evaluation of effectiveness of diethylcarbamazine/albendazole combination in reduction of Wuchereria bancrofti infection using multiple infection parameters"" does not provide indirect support for the phrase ""Methylprednisolone related to autoimmune thrombocytopenic purpura"". The statement is about an evaluation of two drugs (diethylcarbamazine/albendazole) in reducing Wuchereria bancrofti infection, which is unrelated to methylprednisolone and autoimmune thrombocytopenic purpura." -15936572,Methylprednisolone related to endocrine exophthalmos,14,"Our evaluation suggests that although additional studies are needed to determine optimal treatment regimens for intestinal parasites, especially among young children and pregnant women, a five-day course of pre-departure albendazole was effective in reducing helminthic infection in treated refugees.",False,"Is the triple 'Methylprednisolone related to endocrine exophthalmos' supported by the sentence: 'Our evaluation suggests that although additional studies are needed to determine optimal treatment regimens for intestinal parasites, especially among young children and pregnant women, a five-day course of pre-departure albendazole was effective in reducing helminthic infection in treated refugees.'?","No, the statement does not provide indirect support for the phrase ""Methylprednisolone related to endocrine exophthalmos."" The provided statement discusses the effectiveness of pre-departure albendazole treatment in reducing helminthic infection in refugees, which is unrelated to methylprednisolone or endocrine exophthalmos. Endocrine exophthalmos is often associated with Graves' disease, an autoimmune disorder, which would not be directly influenced by anthelmintic drugs like albendazole. Methylprednisolone is a corticosteroid used in various inflammatory conditions but has no direct linkage to endocrine exophthalmos based on this statement." -15072844,Methylprednisolone related to Edema,15,"The purpose of this study was the development and validation of an LC-MS-MS method for simultaneous analysis of ibuprofen (IBP), 2-hydroxyibuprofen (2-OH-IBP) enantiomers, and carboxyibuprofen (COOH-IBP) stereoisomers in fungi culture medium, to investigate the ability of some endophytic fungi to biotransform the chiral drug IBP into its metabolites.",False,"Is the triple 'Methylprednisolone related to Edema' supported by the sentence: 'The purpose of this study was the development and validation of an LC-MS-MS method for simultaneous analysis of ibuprofen (IBP), 2-hydroxyibuprofen (2-OH-IBP) enantiomers, and carboxyibuprofen (COOH-IBP) stereoisomers in fungi culture medium, to investigate the ability of some endophytic fungi to biotransform the chiral drug IBP into its metabolites.'?","No, the statement does not provide indirect support for the phrase ""Methylprednisolone related to Edema"". The study mentioned is focused on developing and validating a method for analyzing ibuprofen (IBP) and its metabolites in fungi culture medium. Methylprednisolone is not mentioned in the statement, nor is there any connection made between it and edema or any other condition. Therefore, it is not appropriate to make such an inference based on the provided information." -14876749,Methylprednisolone related to osteoarthritis,16,"AIMS: To carry out a randomized clinical trial to compare the effect of palmitoylethanolamide (PEA) versus ibuprofen, a nonsteroidal anti-inflammatory drug (NSAID), for pain relief in temporomandibular joint (TMJ) osteoarthritis or arthralgia.",False,"Is the triple 'Methylprednisolone related to osteoarthritis' supported by the sentence: 'AIMS: To carry out a randomized clinical trial to compare the effect of palmitoylethanolamide (PEA) versus ibuprofen, a nonsteroidal anti-inflammatory drug (NSAID), for pain relief in temporomandibular joint (TMJ) osteoarthritis or arthralgia.'?","No, the statement does not provide indirect support for the phrase ""Methylprednisolone related to osteoarthritis."" The statement describes a randomized clinical trial comparing the effects of two substances (palmitoylethanolamide (PEA) and ibuprofen) on pain relief in temporomandibular joint (TMJ) osteoarthritis or arthralgia. Methylprednisolone is not mentioned in the statement; therefore, there is no connection or support for the relationship between methylprednisolone and osteoarthritis in this context." -14399082,Methylprednisolone related to aplastic anemia,17,"We investigated the analgesic efficacy of single doses of ibuprofen, tramadol and pregabalin in menthol-evoked cold pain in a randomized, placebo-controlled four-way cross-over study in 20 healthy volunteers.",False,"Is the triple 'Methylprednisolone related to aplastic anemia' supported by the sentence: 'We investigated the analgesic efficacy of single doses of ibuprofen, tramadol and pregabalin in menthol-evoked cold pain in a randomized, placebo-controlled four-way cross-over study in 20 healthy volunteers.'?","No, the statement does not provide indirect support for the phrase ""Methylprednisolone related to aplastic anemia."" The study mentioned investigates the analgesic efficacy of single doses of ibuprofen, tramadol, and pregabalin in menthol-evoked cold pain in healthy volunteers. Methylprednisolone is not mentioned in the study at all, let alone its relation to aplastic anemia. Aplastic anemia is also not discussed in this context. Therefore, there is no connection that can be inferred between methylprednisolone and aplastic anemia from this statement." -14398237,Methylprednisolone related to IgA glomerulonephritis,18,Double blind study on emorfazone and ibuprofen in dental pain and inflammation.,False,Is the triple 'Methylprednisolone related to IgA glomerulonephritis' supported by the sentence: 'Double blind study on emorfazone and ibuprofen in dental pain and inflammation.'?,"No, the statement ""Methylprednisolone related to IgA glomerulonephritis"" does not receive indirect support from the study on emorfazone and ibuprofen in dental pain and inflammation. The two statements discuss different subjects: methylprednisolone is a corticosteroid used primarily for its anti-inflammatory effect, while IgA glomerulonephritis is a kidney disease often associated with immune system disorders; emorfazone and ibuprofen are both non-steroidal anti-inflammatory drugs (NSAIDs) used primarily for pain relief and reducing inflammation. + While both ibuprofen and methylprednisolone have" +17649050,Methylprednisolone affects optic nerve disorder,49,This study evaluated whether administration of the pharmacologically active S(+)-isomer of ibuprofen suppresses acute pain and plasma beta-endorphin levels in the oral surgery model of acute pain.,False,"'Does the phrase ""Methylprednisolone affects optic nerve disorder"" receive at least indirect support from the statement: ""This study evaluated whether administration of the pharmacologically active S(+)-isomer of ibuprofen suppresses acute pain and plasma beta-endorphin levels in the oral surgery model of acute pain.""?","No, the statement does not provide indirect support for the phrase ""Methylprednisolone affects optic nerve disorder"". The study mentioned in the statement is investigating whether administering a specific isomer of ibuprofen can suppress acute pain and plasma beta-endorphin levels in an oral surgery model of acute pain. This study has no direct relevance to Methylprednisolone or its effects on optic nerve disorders." +16634377,Methylprednisolone affects myasthenia gravis,50,"On the other hand, in subgroup B, no improvement in flexibility or reduction in muscle soreness was found in patients who took ibuprofen.",False,"'Does the phrase ""Methylprednisolone affects myasthenia gravis"" receive at least indirect support from the statement: ""On the other hand, in subgroup B, no improvement in flexibility or reduction in muscle soreness was found in patients who took ibuprofen.""?","No, the statement does not provide indirect support for the phrase ""Methylprednisolone affects myasthenia gravis."" The statement discusses the effects of ibuprofen on flexibility and muscle soreness in subgroup B patients, not methylprednisolone or its effects on myasthenia gravis. Myasthenia gravis is a specific neuromuscular disorder characterized by weakness in voluntary muscle groups; it is not related to muscle soreness or flexibility. Methylprednisolone is a corticosteroid often used in treating myasthenia gravis due to its anti-inflammatory properties; however, no information regarding methylprednisolone is provided in the statement in question. Therefore, it does not offer indirect support for the claim that methylprednisolone affects myasthenia gravis." +16277488,Methylprednisolone affects neuromyelitis optica,51,"This is termed, Celery Seed Extract (CSE) and has been found to be at least as effective as aspirin, ibuprofen, and naproxen in suppressing arthritis in a model of polyarthritis.",False,"'Does the phrase ""Methylprednisolone affects neuromyelitis optica"" receive at least indirect support from the statement: ""This is termed, Celery Seed Extract (CSE) and has been found to be at least as effective as aspirin, ibuprofen, and naproxen in suppressing arthritis in a model of polyarthritis.""?","No, the statement does not provide indirect support for the phrase ""Methylprednisolone affects neuromyelitis optica."" The statement discusses the efficacy of Celery Seed Extract (CSE) in suppressing arthritis in a model of polyarthritis, which is unrelated to Methylprednisolone's potential effects on neuromyelitis optica. Methylprednisolone is a corticosteroid medication often used to treat inflammatory conditions like neuromyelitis optica, but no connection is made between CSE and methylprednisolone in this statement." +15906642,Methylprednisolone affects Pain,52,INTRODUCTION: Hospitalized patients are often unable to ingest or tolerate oral antipyretics and recently an aqueous formulation of intravenous (IV) ibuprofen was approved by the US-FDA for the reduction of fever in adults.,False,"'Does the phrase ""Methylprednisolone affects Pain"" receive at least indirect support from the statement: ""INTRODUCTION: Hospitalized patients are often unable to ingest or tolerate oral antipyretics and recently an aqueous formulation of intravenous (IV) ibuprofen was approved by the US-FDA for the reduction of fever in adults.""?","No, the statement does not provide indirect support for the phrase ""Methylprednisolone affects Pain"". The introduction discusses hospitalized patients who cannot take oral antipyretics (fever reducers) and introduces an intravenous formulation of ibuprofen for fever reduction in adults. Methylprednisolone is a corticosteroid used primarily for its anti-inflammatory effects rather than its direct impact on pain relief (though reducing inflammation can indirectly alleviate pain). The statement focuses on fever reduction using ibuprofen, which does not provide any implicit evidence that methylprednisolone affects pain." +15610554,Methylprednisolone affects rheumatoid arthritis,53,"OBJECTIVES: This study compared the analgesic effectiveness of acetaminophen-codeine with that of ibuprofen for children with acute traumatic extremity pain, with the hypothesis that the two medications would demonstrate equivalent reduction in pain scores in an emergency department (ED) setting.",False,"'Does the phrase ""Methylprednisolone affects rheumatoid arthritis"" receive at least indirect support from the statement: ""OBJECTIVES: This study compared the analgesic effectiveness of acetaminophen-codeine with that of ibuprofen for children with acute traumatic extremity pain, with the hypothesis that the two medications would demonstrate equivalent reduction in pain scores in an emergency department (ED) setting.""?","No, the statement does not provide indirect support for the claim that ""Methylprednisolone affects rheumatoid arthritis."" The study mentioned in the statement focuses on comparing the analgesic effectiveness of acetaminophen-codeine with ibuprofen for children with acute traumatic extremity pain in an emergency department setting. This study does not involve Methylprednisolone nor rheumatoid arthritis; therefore, it does not provide any relevant information or support regarding that claim. - Although both methylprednisolone and NSAIDs have anti-inflammatory properties, their mechanisms of action differ significantly. Furthermore, no connection is implied between them in the provided statement about the double-blind study on emorfazone and ibuprofen in dental pain and inflammation. Therefore, it does not provide indirect support for any relationship between methylprednisolone and IgA glomerulonephritis." -14278238,"Methylprednisolone related to dermatitis, atopic",19,Glucosamine sulfate compared to ibuprofen in osteoarthritis of the knee.,False,"Is the triple 'Methylprednisolone related to dermatitis, atopic' supported by the sentence: 'Glucosamine sulfate compared to ibuprofen in osteoarthritis of the knee.'?","No, the statement ""Glucosamine sulfate compared to ibuprofen in osteoarthritis of the knee"" does not provide indirect support for the phrase ""Methylprednisolone related to dermatitis, atopic."" These two statements discuss different medical conditions (osteoarthritis vs dermatitis) and different treatments (glucosamine sulfate vs methylprednisolone). The first statement does not make any reference or implication about methylprednisolone nor atopic dermatitis; therefore, it does not offer any indirect support for the connection between methylprednisolone and atopic dermatitis. + In order for a study to provide indirect support for a claim, it should at least share some commonalities regarding either the subject matter (in this case, Methylprednisolone or rheumatoid arthritis) or some underlying biological mechanisms that could potentially connect the two areas of investigation. In this instance, however, there is no such connection between the study mentioned in the statement and the claim about Methylprednisolone affecting rheumatoid arthritis. - To further clarify, methylprednisolone is a corticosteroid often used in treating various inflammatory conditions, while glucosamine sulfate is a supplement used for managing osteoarthritis symptoms. Atopic dermatitis is an allergic skin condition that may be treated using topical corticosteroids like hydrocortisone but not necessarily methylprednisolone. The two statements come from entirely different contexts, making it impossible for one" -14166179,Methylprednisolone related to cardiac arrest,20,INTRODUCTION: The anti-inflammatory and anticoagulant effects of ibuprofen and heparin may enhance skin perfusion in cutaneous scald burns.,False,Is the triple 'Methylprednisolone related to cardiac arrest' supported by the sentence: 'INTRODUCTION: The anti-inflammatory and anticoagulant effects of ibuprofen and heparin may enhance skin perfusion in cutaneous scald burns.'?,"No, the statement does not provide indirect support for the phrase ""Methylprednisolone related to cardiac arrest."" The introduction discusses the potential benefits of ibuprofen and heparin in enhancing skin perfusion in cutaneous scald burns by highlighting their anti-inflammatory and anticoagulant effects. Methylprednisolone is not mentioned in the statement; therefore, no connection can be inferred between it and cardiac arrest in this context. + Methylprednisolone is a type of corticosteroid used primarily for its anti-inflammatory effects in various medical conditions" +15186368,Methylprednisolone affects graft versus host disease,54,"Thus, the anti-inflammatory drug ibuprofen, which has been associated with reduced AD risk in human epidemiological studies, can significantly delay some forms of AD pathology, including amyloid deposition, when administered early in the disease course of a transgenic mouse model of AD.",False,"'Does the phrase ""Methylprednisolone affects graft versus host disease"" receive at least indirect support from the statement: ""Thus, the anti-inflammatory drug ibuprofen, which has been associated with reduced AD risk in human epidemiological studies, can significantly delay some forms of AD pathology, including amyloid deposition, when administered early in the disease course of a transgenic mouse model of AD.""?","No, the statement does not provide indirect support for the phrase ""Methylprednisolone affects graft versus host disease"". The statement discusses the effects of ibuprofen on Alzheimer's disease (AD) pathology in a transgenic mouse model, while the phrase in question pertains to Methylprednisolone's impact on graft versus host disease. These are two distinct areas of study with no overlap in the provided statement." +14891106,Methylprednisolone affects kidney disorder,55,"The hypoxia, hypertension and increased prostanoids were prevented using ibuprofen.",False,"'Does the phrase ""Methylprednisolone affects kidney disorder"" receive at least indirect support from the statement: ""The hypoxia, hypertension and increased prostanoids were prevented using ibuprofen.""?","No, the statement does not provide indirect support for the phrase ""Methylprednisolone affects kidney disorder"". - To provide indirect support for ""Methylprednisolone related to cardiac arrest,"" there would need to be some mention of methylprednisolone in relation to cardiac issues or adverse effects on heart function, which is not present in the given statement." -12755316,Methylprednisolone related to plasma cell myeloma,21,"CONCLUSIONS: Ibuprofen-induced patent ductus arteriosus closure improved pulmonary mechanics, decreased total lung water, increased epithelial sodium channel expression, and decreased the detrimental effects of preterm birth on alveolarization.",False,"Is the triple 'Methylprednisolone related to plasma cell myeloma' supported by the sentence: 'CONCLUSIONS: Ibuprofen-induced patent ductus arteriosus closure improved pulmonary mechanics, decreased total lung water, increased epithelial sodium channel expression, and decreased the detrimental effects of preterm birth on alveolarization.'?","No, the statement does not provide indirect support for the phrase ""Methylprednisolone related to plasma cell myeloma."" The conclusion discusses the effects of ibuprofen on patent ductus arteriosus closure in preterm births, which is unrelated to methylprednisolone usage in plasma cell myeloma cases. The two subjects involve different medications and medical conditions, making it inappropriate to draw any connections between them based on this statement alone." -12183687,Methylprednisolone related to acute lymphoblastic leukemia,22,Protein profile in neuroblastoma cells incubated with S- and R-enantiomers of ibuprofen by iTRAQ-coupled 2-D LC-MS/MS analysis: possible action of induced proteins on Alzheimer's disease.,False,Is the triple 'Methylprednisolone related to acute lymphoblastic leukemia' supported by the sentence: 'Protein profile in neuroblastoma cells incubated with S- and R-enantiomers of ibuprofen by iTRAQ-coupled 2-D LC-MS/MS analysis: possible action of induced proteins on Alzheimer's disease.'?,"No, the statement does not provide indirect support for the phrase ""Methylprednisolone related to acute lymphoblastic leukemia."" The statement discusses neuroblastoma cells incubated with S-and R-enantiomers of ibuprofen, not methylprednisolone, and focuses on protein profiles possibly influencing Alzheimer's disease, not acute lymphoblastic leukemia." -11720471,Methylprednisolone related to systemic lupus erythematosus,23,Protective effect of glucosamine against ibuprofen-induced peptic ulcer in rats.,False,Is the triple 'Methylprednisolone related to systemic lupus erythematosus' supported by the sentence: 'Protective effect of glucosamine against ibuprofen-induced peptic ulcer in rats.'?,"No, the statement ""Protective effect of glucosamine against ibuprofen-induced peptic ulcer in rats"" does not provide indirect support for the phrase ""Methylprednisolone related to systemic lupus erythematosus"". + The statement ""The hypoxia, hypertension and increased prostanoids were prevented using ibuprofen"" refers to the prevention of specific symptoms (hypoxia, hypertension, and increased prostanoids) by ibuprofen. Methylprednisolone is not mentioned in this statement, nor is there any connection made between methylprednisolone and kidney disorder. - The reason for this is that the two statements discuss entirely different subjects. The first statement refers to the protective effect of glucosamine on ibuprofen-induced peptic ulcers in rats, which is an investigation into gastrointestinal side effects caused by non-steroidal anti-inflammatory drugs (NSAIDs). In contrast, the second phrase discusses Methylprednisolone, which is a corticosteroid used primarily for its anti-inflammatory effects in various clinical settings such as systemic lupus erythematosus (SLE). + Furthermore, while ibuprofen is known for its anti-inflammatory effects, methylprednisolone is a corticosteroid often used for its anti-inflammatory and immunosuppressive properties. They have different mechanisms of action and are used to treat different conditions. Therefore, even if methylprednisolone was mentioned in the statement, it would not necessarily imply a connection to kidney disorder based on this information alone. - While both glucosamine and Methylprednisolone have anti-inflammatory properties, they belong to different classes of drugs (nutraceuticals and corticosteroids, respectively) that have distinct mechanisms of action, therapeutic uses, and adverse effect profiles" -10812685,Methylprednisolone related to immunoglobulin a vasculitis,24,Ibuprofen-induced fever in Sjogren's syndrome.,False,Is the triple 'Methylprednisolone related to immunoglobulin a vasculitis' supported by the sentence: 'Ibuprofen-induced fever in Sjogren's syndrome.'?,"No, the statement ""Ibuprofen-induced fever in Sjogren's syndrome"" does not provide indirect support for the phrase ""Methylprednisolone related to immunoglobulin A vasculitis."" + However, it is important to note that both methylprednisolone and ibuprofen can have side effects on kidney function when used inappropriately or in" +11819955,Methylprednisolone affects spinal cord injury,56,"The Effect of Ibuprofen Dosing Interval on Post-Tonsillectomy Outcomes in Children: A Quality Improvement Study.OBJECTIVE: In this Quality Improvement (QI project) it was hypothesized that an increase in dosing intervals for postoperative analgesia when alternating Ibuprofen and Acetaminophen would reduce post-tonsillectomy hemorrhage (PTH) rates for those undergoing tonsillectomies with or without adenoidectomy, while maintaining the standard of postoperative analgesia and reducing visits to the Emergency Room (ER) for reasons other than PTH.",False,"'Does the phrase ""Methylprednisolone affects spinal cord injury"" receive at least indirect support from the statement: ""The Effect of Ibuprofen Dosing Interval on Post-Tonsillectomy Outcomes in Children: A Quality Improvement Study.OBJECTIVE: In this Quality Improvement (QI project) it was hypothesized that an increase in dosing intervals for postoperative analgesia when alternating Ibuprofen and Acetaminophen would reduce post-tonsillectomy hemorrhage (PTH) rates for those undergoing tonsillectomies with or without adenoidectomy, while maintaining the standard of postoperative analgesia and reducing visits to the Emergency Room (ER) for reasons other than PTH.""?","No, the statement does not provide indirect support for the phrase ""Methylprednisolone affects spinal cord injury."" The study focuses on postoperative analgesia outcomes in children undergoing tonsillectomies when alternating Ibuprofen and Acetaminophen dosing intervals. The drug mentioned in this context is Ibuprofen, not Methylprednisolone. Moreover, spinal cord injury is not addressed in either the hypothesis or the study objectives. Therefore, there is no connection between the two statements in terms of content or subject matter." +10845505,Methylprednisolone affects Pain,57,Studies show that ibuprofen demonstrates superior efficacy in fever reduction compared to acetaminophen.,False,"'Does the phrase ""Methylprednisolone affects Pain"" receive at least indirect support from the statement: ""Studies show that ibuprofen demonstrates superior efficacy in fever reduction compared to acetaminophen.""?","No, the statement does not provide any indirect support for the phrase ""Methylprednisolone affects Pain."" The statement compares the efficacy of two different drugs (ibuprofen and acetaminophen) in reducing fever, but it does not mention Methylprednisolone or pain at all. Methylprednisolone is a corticosteroid used primarily for its anti-inflammatory effects rather than its analgesic (pain-relieving) properties, so any connection between the two statements would be purely speculative and not based on the evidence provided." +10048898,Methylprednisolone affects ulcerative colitis,58,IV Ibuprofen for Prevention of Post-Ercp Pancreatitis in Children: A Randomized Placebo-Controlled Feasibility Study.,False,"'Does the phrase ""Methylprednisolone affects ulcerative colitis"" receive at least indirect support from the statement: ""IV Ibuprofen for Prevention of Post-Ercp Pancreatitis in Children: A Randomized Placebo-Controlled Feasibility Study.""?","No, the statement ""IV Ibuprofen for Prevention of Post-Ercp Pancreatitis in Children: A Randomized Placebo-Controlled Feasibility Study"" does not provide indirect support for the phrase ""Methylprednisolone affects ulcerative colitis."" - - The two statements discuss different medical conditions and drugs. Sjogren's syndrome is an autoimmune disorder characterized by dry eyes and mouth, while immunoglobulin A vasculitis (IgAV), previously known as Henoch-Schönlein purpura, is a type of vasculitis that affects small blood vessels. Methylprednisolone is a corticosteroid used in various inflammatory conditions, including IgAV, whereas ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) that can cause fever as an adverse effect in some patients. + The study in question is investigating the use of IV Ibuprofen for preventing post-ERCP (Endoscopic Retrograde Cholangiopancreatography) pancreatitis in children. This study does not involve Methylprednisolone or ulcerative colitis at all, making it unrelated to the claim about Methylprednisolone's effect on ulcerative colitis. - - Although both methylprednisolone and ibuprofen can be used in inflammatory conditions, they belong to different drug classes (corticosteroids vs NSAIDs) and have distinct mechanisms of action. Therefore, one statement does not provide indirect" -10763477,Methylprednisolone related to ulcerative colitis,25,There have been no prior definite cases reported of ibuprofen-induced pancreatitis.,False,Is the triple 'Methylprednisolone related to ulcerative colitis' supported by the sentence: 'There have been no prior definite cases reported of ibuprofen-induced pancreatitis.'?,"No, the statement ""There have been no prior definite cases reported of ibuprofen-induced pancreatitis"" does not provide indirect support for the phrase ""Methylprednisolone related to ulcerative colitis."" - - The two statements discuss different medications (ibuprofen and methylprednisolone) and different medical conditions (pancreatitis and ulcerative colitis). Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID), while methylprednisolone is a corticosteroid used primarily for its anti-inflammatory effects in various conditions such as ulcerative colitis. - - The lack of reported ibuprofen-induced pancreatitis cases does not imply any connection between methylprednisolone and ulcerative colitis, as these medications have different mechanisms of action and potential side effects. To establish any relationship between methylprednisolone and ulcerative colitis, direct evidence from relevant studies would be required, focusing on methylprednisolone use in ulcerative colitis patients and its associated outcomes, side effects, or benefits." -10558884,Methylprednisolone related to lupus nephritis,26,"RESULTS: None of the studies established any of the COX-2 inhibitors as clearly better than ibuprofen, the current gold standard for the treatment of surgically induced dental pain.",False,"Is the triple 'Methylprednisolone related to lupus nephritis' supported by the sentence: 'RESULTS: None of the studies established any of the COX-2 inhibitors as clearly better than ibuprofen, the current gold standard for the treatment of surgically induced dental pain.'?","No, the statement does not provide indirect support for the phrase ""Methylprednisolone related to lupus nephritis."" The statement discusses studies comparing COX-2 inhibitors (such as celecoxib) to ibuprofen for treating surgically induced dental pain, without mentioning methylprednisolone or lupus nephritis at all. Methylprednisolone is a corticosteroid used primarily for its anti-inflammatory effects in various conditions like asthma, rheumatoid arthritis, and lupus nephritis flares; it is not a COX-2 inhibitor nor an NSAID like ibuprofen. Therefore, these results do not provide any relevant evidence regarding methylprednisolone's relationship to lupus nephritis." -10130342,Methylprednisolone related to adult acute respiratory distress syndrome,27,Noncardiogenic pulmonary edema due to ibuprofen.,False,Is the triple 'Methylprednisolone related to adult acute respiratory distress syndrome' supported by the sentence: 'Noncardiogenic pulmonary edema due to ibuprofen.'?,"No, the statement ""Noncardiogenic pulmonary edema due to ibuprofen"" does not provide indirect support for the phrase ""Methylprednisolone related to adult acute respiratory distress syndrome."" - - The two statements describe different drugs (ibuprofen and methylprednisolone) causing distinct medical conditions (noncardiogenic pulmonary edema and adult acute respiratory distress syndrome). While both conditions affect lung function, they represent different pathophysiological mechanisms: noncardiogenic pulmonary edema is characterized by increased fluid accumulation in lung tissue due to increased permeability, while adult acute respiratory distress syndrome (ARDS) is an inflammatory lung injury leading to hypoxemia (low oxygen levels in blood) due to impaired gas exchange in alveoli. - - Methylprednisolone is a corticosteroid commonly used in treating various inflammatory conditions; however, its use in ARDS remains controversial due to potential side effects like increased susceptibility to infections. Ibuprofen is an NSAID (nonsteroidal anti-inflammatory drug" -9229208,Methylprednisolone related to vestibular neuronitis,28,"In a double-blind cross-over study on 22 healthy subjects the analgesic efficacies of the antipyretic analgesic drugs ibuprofen, dipyrone and paracetamol were tested against placebo using a model of experimentally induced pain.",False,"Is the triple 'Methylprednisolone related to vestibular neuronitis' supported by the sentence: 'In a double-blind cross-over study on 22 healthy subjects the analgesic efficacies of the antipyretic analgesic drugs ibuprofen, dipyrone and paracetamol were tested against placebo using a model of experimentally induced pain.'?","No, the statement does not provide indirect support for the phrase ""Methylprednisolone related to vestibular neuronitis"". The study mentioned in the statement focuses on testing analgesic efficacies of ibuprofen, dipyrone, paracetamol against placebo in experimentally induced pain in 22 healthy subjects. Methylprednisolone is not included in these drugs nor is there any reference made to vestibular neuronitis in the study. Vestibular neuronitis is an inner ear disorder causing vertigo while methylprednisolone is a corticosteroid used primarily for its anti-inflammatory effects in various conditions. Therefore, there is no connection between methylprednisolone and vestibular neuronitis in this context." -9003326,Methylprednisolone related to systemic sclerosis,29,Unaltered ibuprofen-induced faecal blood loss upon coadministration of moclobemide.,False,Is the triple 'Methylprednisolone related to systemic sclerosis' supported by the sentence: 'Unaltered ibuprofen-induced faecal blood loss upon coadministration of moclobemide.'?,"No, the statement does not provide indirect support for the phrase ""Methylprednisolone related to systemic sclerosis."" The statement discusses the effect of ibuprofen-induced faecal blood loss when coadministered with moclobemide, which is unrelated to methylprednisolone or systemic sclerosis. Methylprednisolone is a corticosteroid used primarily for its anti-inflammatory effects, while systemic sclerosis is an autoimmune disease characterized by hardening of the skin and connective tissues. The connection between these entities is not evident based on the provided statement." -8447481,Methylprednisolone related to rheumatoid arthritis,30,The C5a antagonist (1 or 3 mg/kg/day) and/or ibuprofen (30 mg/kg/day) were administered orally on a daily basis either before or after arthritis induction.,False,Is the triple 'Methylprednisolone related to rheumatoid arthritis' supported by the sentence: 'The C5a antagonist (1 or 3 mg/kg/day) and/or ibuprofen (30 mg/kg/day) were administered orally on a daily basis either before or after arthritis induction.'?,"No, the statement does not provide direct or indirect support for the phrase ""Methylprednisolone related to rheumatoid arthritis."" The statement discusses the administration of C5a antagonist and ibuprofen in relation to arthritis induction but does not mention Methylprednisolone or its relation to rheumatoid arthritis." -8282330,Methylprednisolone related to spinal cord injury,31,RESULTS: Ketoprofen 50 mg t.d.s. suppressed prostaglandin synthesis to a significantly greater extent than ibuprofen and caused significantly more gastroduodenal injury.,False,Is the triple 'Methylprednisolone related to spinal cord injury' supported by the sentence: 'RESULTS: Ketoprofen 50 mg t.d.s. suppressed prostaglandin synthesis to a significantly greater extent than ibuprofen and caused significantly more gastroduodenal injury.'?,"No, the statement does not provide indirect support for the phrase ""Methylprednisolone related to spinal cord injury."" The statement discusses the effects of Ketoprofen and Ibuprofen on prostaglandin synthesis and gastroduodenal injury, making no mention of Methylprednisolone or its relationship to spinal cord injury. Methylprednisolone is a type of corticosteroid often used in treating various medical conditions, including spinal cord injuries, but the evidence provided here does not support any connection between it and spinal cord injury." -7944646,Methylprednisolone related to myasthenia gravis,32,The duration of action of sustained-release ibuprofen ('Brufen Retard') was investigated in a 14-day double-blind study involving 14 osteoarthritis and 10 rheumatoid arthritis patients.,False,Is the triple 'Methylprednisolone related to myasthenia gravis' supported by the sentence: 'The duration of action of sustained-release ibuprofen ('Brufen Retard') was investigated in a 14-day double-blind study involving 14 osteoarthritis and 10 rheumatoid arthritis patients.'?,"No, the statement does not provide indirect support for the phrase ""Methylprednisolone related to myasthenia gravis."" The study mentioned in the statement investigates the duration of action of sustained-release ibuprofen (Brufen Retard) in osteoarthritis and rheumatoid arthritis patients. Methylprednisolone is a corticosteroid used primarily for its anti-inflammatory effects in various conditions, while myasthenia gravis is an autoimmune neuromuscular disorder affecting voluntary muscle function. There is no mention or implication of methylprednisolone, myasthenia gravis, or any related concepts in the provided statement." -7668599,Methylprednisolone related to multiple sclerosis,33,This study attempts to investigate the effect of ibuprofen on reducing eye pain and migraine headaches caused by trochleitis.,False,Is the triple 'Methylprednisolone related to multiple sclerosis' supported by the sentence: 'This study attempts to investigate the effect of ibuprofen on reducing eye pain and migraine headaches caused by trochleitis.'?,"No, the statement does not provide indirect support for the phrase ""Methylprednisolone related to multiple sclerosis."" The study mentioned is investigating the effect of ibuprofen on reducing eye pain and migraine headaches caused by trochleitis. There is no mention or implication of methylprednisolone or multiple sclerosis in this context. Methylprednisolone is a corticosteroid used primarily for its anti-inflammatory effects in various conditions, while multiple sclerosis is an autoimmune disease affecting the central nervous system; they share no direct relationship to each other nor to ibuprofen or trochleitis in this specific case." -7443745,Methylprednisolone related to asthma,34,"Ibuprofen suppresses the production of various pro-inflammatory cytokines that are implicated in the ""cytokine storm"" and subsequent ARDS in COVID-19 disease.",False,"Is the triple 'Methylprednisolone related to asthma' supported by the sentence: 'Ibuprofen suppresses the production of various pro-inflammatory cytokines that are implicated in the ""cytokine storm"" and subsequent ARDS in COVID-19 disease.'?","No, the statement does not provide indirect support for the phrase ""Methylprednisolone related to asthma."" The two statements discuss different medications (Ibuprofen vs Methylprednisolone) and different medical conditions (COVID-19 vs asthma). Ibuprofen's effect on COVID-19 does not imply any connection to Methylprednisolone's potential relation to asthma. Methylprednisolone is a corticosteroid often used in asthma treatment due to its anti-inflammatory properties; however, that is not mentioned nor implied in the original statement about Ibuprofen and COVID-19." -24973247,Methylprednisolone causes lupus nephritis,35,"After adjusting for covariates, the risk of BPD was associated independently with ibuprofen exposure (odds ratios (OR) 2.296, 95% confidence interval (CI): 1.166-4.522, p = 0.016).",False,"Is the triple 'Methylprednisolone causes lupus nephritis' supported by the sentence: 'After adjusting for covariates, the risk of BPD was associated independently with ibuprofen exposure (odds ratios (OR) 2.296, 95% confidence interval (CI): 1.166-4.522, p = 0.016).'?","No, the statement does not provide any indirect support for the claim that ""Methylprednisolone causes lupus nephritis."" The statement discusses the association between ibuprofen exposure and bronchopulmonary dysplasia (BPD) in infants, adjusted for covariates. Methylprednisolone is not mentioned in the statement at all; hence, there is no link between the two pieces of information that would allow for indirect support. Lupus nephritis is also not mentioned in either statement. Therefore, it is not possible to draw any conclusions about the relationship between methylprednisolone use and lupus nephritis based on these statements alone." -24161886,Methylprednisolone causes Edema,36,The opposite effect of ibuprofen on ethanol-induced cognitive impairment as measured by two lateralized functions is consistent with the reports in tissue and animal models that central nervous system effects of ethanol may be mediated at least in part by prostaglandins.,False,Is the triple 'Methylprednisolone causes Edema' supported by the sentence: 'The opposite effect of ibuprofen on ethanol-induced cognitive impairment as measured by two lateralized functions is consistent with the reports in tissue and animal models that central nervous system effects of ethanol may be mediated at least in part by prostaglandins.'?,"No, the statement does not provide indirect support for the phrase ""Methylprednisolone causes Edema"". - - The statement discusses the opposite effect of ibuprofen on ethanol-induced cognitive impairment, which is suggested to be mediated by prostaglandins in tissue and animal models. Methylprednisolone is a corticosteroid medication used for its anti-inflammatory and immunosuppressive effects, and it does not have a direct connection to prostaglandins, ethanol, or cognitive impairment as described in the statement. Therefore, there is no implied relationship between methylprednisolone and edema in this context." -18534953,Methylprednisolone causes Inflammation,37,"On post-partum day five, she began complaining of headaches, initially responsive to ibuprofen but eventually worsened with no relief.",False,"Is the triple 'Methylprednisolone causes Inflammation' supported by the sentence: 'On post-partum day five, she began complaining of headaches, initially responsive to ibuprofen but eventually worsened with no relief.'?","No, the phrase ""Methylprednisolone causes Inflammation"" does not receive indirect support from the statement: ""On post-partum day five, she began complaining of headaches, initially responsive to ibuprofen but eventually worsened with no relief."" - - The statement describes a patient who developed headaches on post-partum day five that were initially responsive to ibuprofen but later became unresponsive. Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID), which suggests that inflammation might have been involved in the initial stages of her headaches. However, methylprednisolone is a glucocorticoid steroid used primarily for its anti-inflammatory effects in various clinical scenarios (e.g., treating inflammatory conditions such as multiple sclerosis). The worsening of her headaches despite initial responsiveness to an anti-inflammatory medication like ibuprofen does not support methylprednisolone causing inflammation; instead, it suggests that her condition might not have been primarily inflammatory in nature or that other factors were contributing to" -18260665,Methylprednisolone causes neoplasm,38,"Because ibuprofen protects from septic lung injury, we studied the effect of ibuprofen in oxidant lung injury from phosgene.",False,"Is the triple 'Methylprednisolone causes neoplasm' supported by the sentence: 'Because ibuprofen protects from septic lung injury, we studied the effect of ibuprofen in oxidant lung injury from phosgene.'?","No, the statement does not provide any indirect support for the phrase ""Methylprednisolone causes neoplasm."" - - The initial statement discusses a study involving ibuprofen in oxidant lung injury from phosgene due to its protective effects against septic lung injury. This study does not involve methylprednisolone or any discussion related to neoplasm (abnormal tissue growth that can lead to cancer). Therefore, it does not provide any basis or evidence to suggest that methylprednisolone causes neoplasm. - - The two statements are unrelated in terms of their subject matter and do not share any common elements that would allow for an indirect inference about methylprednisolone causing neoplasm." -17307095,Methylprednisolone causes pneumonia,39,The efficacy and tolerance of ibuprofen retard at a dose of 2 x 800 mg daily was investigated in an open multicenter study over a period of 3 weeks on 7931 out-patients with activated degenerative joint disease and/or extraarticular rheumatic symptoms.,False,Is the triple 'Methylprednisolone causes pneumonia' supported by the sentence: 'The efficacy and tolerance of ibuprofen retard at a dose of 2 x 800 mg daily was investigated in an open multicenter study over a period of 3 weeks on 7931 out-patients with activated degenerative joint disease and/or extraarticular rheumatic symptoms.'?,"No, the statement does not provide any indirect support for the claim that ""Methylprednisolone causes pneumonia"". The statement discusses a study on ibuprofen's efficacy and tolerance in patients with joint disease and rheumatic symptoms, but it does not mention Methylprednisolone or pneumonia at all. Therefore, it does not contribute any evidence, either positive or negative, towards the claim in question." -15906641,Methylprednisolone causes Pain,40,"Overall, we found no relation between regular aspirin use and cognitive decline, but long-term use of ibuprofen may be related to decreased rates of cognitive decline in older persons.",False,"Is the triple 'Methylprednisolone causes Pain' supported by the sentence: 'Overall, we found no relation between regular aspirin use and cognitive decline, but long-term use of ibuprofen may be related to decreased rates of cognitive decline in older persons.'?","No, the statement does not provide indirect support for the phrase ""Methylprednisolone causes Pain."" The provided statement discusses the relationship between regular aspirin use, ibuprofen use, and cognitive decline in older persons; it does not mention Methylprednisolone or pain at all. Methylprednisolone is a corticosteroid used primarily for its anti-inflammatory effects, while aspirin and ibuprofen are nonsteroidal anti-inflammatory drugs (NSAIDs). The provided statement does not offer any evidence or reasoning that could be used to infer a relationship between Methylprednisolone and pain." -13166073,Methylprednisolone causes thrombocytopenia,41,"Subdiaphragmatic vagotomy or 7-nitroindazole reduced, icatibant, DALBK, IL-1ra, aminoguanidine and dipyrone abolished, while ibuprofen and celecoxib failed to affect Tsv-induced fever.",False,"Is the triple 'Methylprednisolone causes thrombocytopenia' supported by the sentence: 'Subdiaphragmatic vagotomy or 7-nitroindazole reduced, icatibant, DALBK, IL-1ra, aminoguanidine and dipyrone abolished, while ibuprofen and celecoxib failed to affect Tsv-induced fever.'?","No, the statement does not provide indirect support for the phrase ""Methylprednisolone causes thrombocytopenia"". The statement discusses various substances (subdiaphragmatic vagotomy, 7-nitroindazole, icatibant, DALBK, IL-1ra, aminoguanidine, dipyrone, ibuprofen, and celecoxib) affecting Tsv-induced fever in rats, but it does not mention methylprednisolone nor thrombocytopenia (a condition characterized by abnormally low levels of platelets in the blood). Methylprednisolone is a corticosteroid medication used for various inflammatory conditions, while thrombocytopenia is not related to fever in rats. Therefore, there is no connection between the two statements that would allow for indirect support of the claim about methylprednisolone causing thrombocytopenia." -12672767,Methylprednisolone causes drug-induced liver injury,42,Reduced incidence of gastroduodenal ulcers associated with lumiracoxib compared with ibuprofen in patients with rheumatoid arthritis.,False,Is the triple 'Methylprednisolone causes drug-induced liver injury' supported by the sentence: 'Reduced incidence of gastroduodenal ulcers associated with lumiracoxib compared with ibuprofen in patients with rheumatoid arthritis.'?,"No, the statement does not provide indirect support for the phrase ""Methylprednisolone causes drug-induced liver injury"". - - The statement discusses the reduced incidence of gastroduodenal ulcers associated with lumiracoxib compared to ibuprofen in patients with rheumatoid arthritis. This has no direct or indirect relation to methylprednisolone, which is not mentioned in the statement. Methylprednisolone is a corticosteroid often used for its anti-inflammatory effects, while lumiracoxib and ibuprofen are non-steroidal anti-inflammatory drugs (NSAIDs). - - Drug-induced liver injury is indeed a potential side effect of some medications, including certain corticosteroids like methylprednisolone. However, the statement provided does not contain any information that could be used to infer or imply this relationship. Therefore, it does not provide indirect support for the claim that methylprednisolone causes drug-induced liver injury." -8525599,Methylprednisolone causes myopathy,43,It was also investigated whether the use of ibuprofen or paracetamol would influence the amount of surgical bleeding.,False,Is the triple 'Methylprednisolone causes myopathy' supported by the sentence: 'It was also investigated whether the use of ibuprofen or paracetamol would influence the amount of surgical bleeding.'?,"No, the statement does not provide any indirect support for the claim that ""Methylprednisolone causes myopathy."" - - The statement discusses an investigation into whether ibuprofen or paracetamol has an impact on surgical bleeding. This is unrelated to methylprednisolone or myopathy (muscle disease). Myopathy is a side effect associated with methylprednisolone use; however, the provided statement does not mention methylprednisolone or myopathy, making it irrelevant in supporting the initial claim." -27357949,Methylprednisolone affects neoplasm,44,"In a randomised, placebo-controlled, double-blind trial of prophylaxis with ibuprofen, the rate of patent ductus arteriosus associated with ibuprofen was 19% compared with 42% with placebo.",False,"Is the triple 'Methylprednisolone affects neoplasm' supported by the sentence: 'In a randomised, placebo-controlled, double-blind trial of prophylaxis with ibuprofen, the rate of patent ductus arteriosus associated with ibuprofen was 19% compared with 42% with placebo.'?","No, the statement does not provide direct or indirect support for the phrase ""Methylprednisolone affects neoplasm."" The study mentioned involves ibuprofen use in preventing patent ductus arteriosus (PDA), which is not related to neoplasm (abnormal tissue growth that can lead to cancer). Methylprednisolone is also not mentioned in the study. Therefore, there is no link between methylprednisolone and its effect on neoplasm based on this statement alone. - - However, it is important to note that methylprednisolone has been studied in relation to cancer treatment as it can modulate immune response and inflammation; however, its direct effect on neoplasm growth remains unclear and more evidence would be needed for such a claim." -24420470,Methylprednisolone affects Inflammation,45,"The purpose of this study was to examine the effects of ibuprofen on delayed onset muscle soreness (DOMS), indirect markers of muscle damage and muscular performance.",False,"Is the triple 'Methylprednisolone affects Inflammation' supported by the sentence: 'The purpose of this study was to examine the effects of ibuprofen on delayed onset muscle soreness (DOMS), indirect markers of muscle damage and muscular performance.'?","No, the statement does not provide indirect support for the claim that ""Methylprednisolone affects Inflammation."" The study focuses on ibuprofen, another anti-inflammatory drug, examining its effects on delayed onset muscle soreness (DOMS), indirect markers of muscle damage, and muscular performance. The fact that ibuprofen has these effects does not necessarily imply that methylprednisolone would have similar effects on inflammation since different drugs can have different mechanisms of action. To establish indirect support for methylprednisolone affecting inflammation from this study, there would need to be some comparison between ibuprofen and methylprednisolone, which is not present in the given statement." -23472756,Methylprednisolone affects Inflammation,46,CONCLUSIONS: Pretreatment with ibuprofen before elective total hip surgery increases the perioperative blood loss significantly.,False,Is the triple 'Methylprednisolone affects Inflammation' supported by the sentence: 'CONCLUSIONS: Pretreatment with ibuprofen before elective total hip surgery increases the perioperative blood loss significantly.'?,"No, the statement does not provide direct or indirect support for the phrase ""Methylprednisolone affects Inflammation."" The conclusion in question discusses the effect of ibuprofen on perioperative blood loss in elective total hip surgery, which is not related to Methylprednisolone or inflammation in any discernible way based on the information provided. Methylprednisolone is a corticosteroid used primarily for its anti-inflammatory effects; however, no mention or implication is made in this statement regarding Methylprednisolone or its potential impact on inflammation." -20530617,Methylprednisolone affects systemic sclerosis,47,"The data suggest that nimesulide and ibuprofen, in addition to their anti-inflammatory and analgesic benefits, may also have a protective effect in osteoarthritis through the inhibition of apoptosis in chondrocytes.",False,"Is the triple 'Methylprednisolone affects systemic sclerosis' supported by the sentence: 'The data suggest that nimesulide and ibuprofen, in addition to their anti-inflammatory and analgesic benefits, may also have a protective effect in osteoarthritis through the inhibition of apoptosis in chondrocytes.'?","No, the statement does not provide indirect support for the claim that ""Methylprednisolone affects systemic sclerosis."" The statement discusses the potential protective effects of nimesulide and ibuprofen on osteoarthritis through inhibition of apoptosis in chondrocytes, which is unrelated to methylprednisolone or systemic sclerosis. Systemic sclerosis is an autoimmune disease characterized by thickening and scarring of connective tissue supporting skin and internal organs, whereas osteoarthritis is a degenerative joint disease primarily affecting cartilage. Methylprednisolone is a corticosteroid used primarily for its anti-inflammatory effects in various conditions; its impact on systemic sclerosis would require separate investigation and evidence." -20254789,Methylprednisolone affects adult acute respiratory distress syndrome,48,Pretreatment with ibuprofen blocked the fever induced by RANTES.,False,Is the triple 'Methylprednisolone affects adult acute respiratory distress syndrome' supported by the sentence: 'Pretreatment with ibuprofen blocked the fever induced by RANTES.'?,"No, the statement does not provide indirect support for the phrase ""Methylprednisolone affects adult acute respiratory distress syndrome"". The statement ""Pretreatment with ibuprofen blocked the fever induced by RANTES"" discusses the effects of ibuprofen on fever induced by RANTES but does not mention methylprednisolone or its effects on adult acute respiratory distress syndrome (ARDS). - - To provide indirect support for the initial phrase, there would need to be some connection between ibuprofen/RANTES/fever and methylprednisolone/ARDS in the statement. However, no such connection is present in this case. - - It is important to note that while methylprednisolone is sometimes used in treating ARDS due to its anti-inflammatory properties, ibuprofen is primarily used as an analgesic (pain reliever) and antipyretic (fever reducer). They have different mechanisms of action in the body, so one does not necessarily influence the other in terms of their primary effects (ibuprofen reducing fever from RANTES in this case). - - In conclusion" -17649050,Methylprednisolone affects optic nerve disorder,49,This study evaluated whether administration of the pharmacologically active S(+)-isomer of ibuprofen suppresses acute pain and plasma beta-endorphin levels in the oral surgery model of acute pain.,False,Is the triple 'Methylprednisolone affects optic nerve disorder' supported by the sentence: 'This study evaluated whether administration of the pharmacologically active S(+)-isomer of ibuprofen suppresses acute pain and plasma beta-endorphin levels in the oral surgery model of acute pain.'?,"No, the statement does not provide any direct or indirect support for the phrase ""Methylprednisolone affects optic nerve disorder."" The study mentioned in the statement is investigating whether administering ibuprofen suppresses acute pain and plasma beta-endorphin levels in an oral surgery model for acute pain management. This study is focused on ibuprofen and pain management, making it unrelated to methylprednisolone or its potential effects on optic nerve disorders." -16634377,Methylprednisolone affects myasthenia gravis,50,"On the other hand, in subgroup B, no improvement in flexibility or reduction in muscle soreness was found in patients who took ibuprofen.",False,"Is the triple 'Methylprednisolone affects myasthenia gravis' supported by the sentence: 'On the other hand, in subgroup B, no improvement in flexibility or reduction in muscle soreness was found in patients who took ibuprofen.'?","No, the statement does not provide indirect support for the phrase ""Methylprednisolone affects myasthenia gravis."" The statement discusses the effects of ibuprofen on flexibility and muscle soreness in subgroup B patients but does not mention methylprednisolone or myasthenia gravis at all. - - To provide indirect support for the original phrase, there would need to be some connection between methylprednisolone, myasthenia gravis, and either ibuprofen or flexibility/muscle soreness in the statement. Since no such connection exists here, no indirect support can be inferred from the statement provided." -16277488,Methylprednisolone affects neuromyelitis optica,51,"This is termed, Celery Seed Extract (CSE) and has been found to be at least as effective as aspirin, ibuprofen, and naproxen in suppressing arthritis in a model of polyarthritis.",False,"Is the triple 'Methylprednisolone affects neuromyelitis optica' supported by the sentence: 'This is termed, Celery Seed Extract (CSE) and has been found to be at least as effective as aspirin, ibuprofen, and naproxen in suppressing arthritis in a model of polyarthritis.'?","No, the statement does not provide indirect support for the claim that ""Methylprednisolone affects neuromyelitis optica."" The statement discusses Celery Seed Extract (CSE) and its effectiveness in suppressing arthritis in a polyarthritis model. It does not mention Methylprednisolone or neuromyelitis optica, so there is no connection between the two pieces of information that would allow for indirect support. - - To further explain, Methylprednisolone is a corticosteroid medication used for its anti-inflammatory and immunosuppressive effects in various conditions such as allergic reactions, skin conditions, arthritis, asthma, blood disorders, certain eye conditions, kidney problems, and autoimmune diseases among others (Mayo Clinic). Neuromyelitis optica is an autoimmune disease where immune system attacks the optic nerves and spinal cord (National Institute of Neurological Disorders and Stroke). While Methylprednisolone may be used in treating Neuromyelitis optica due to its immunosuppressive properties, the provided statement does not" -15906642,Methylprednisolone affects Pain,52,INTRODUCTION: Hospitalized patients are often unable to ingest or tolerate oral antipyretics and recently an aqueous formulation of intravenous (IV) ibuprofen was approved by the US-FDA for the reduction of fever in adults.,False,Is the triple 'Methylprednisolone affects Pain' supported by the sentence: 'INTRODUCTION: Hospitalized patients are often unable to ingest or tolerate oral antipyretics and recently an aqueous formulation of intravenous (IV) ibuprofen was approved by the US-FDA for the reduction of fever in adults.'?,"No, the statement does not provide indirect support for the phrase ""Methylprednisolone affects Pain."" The statement discusses hospitalized patients who cannot ingest oral antipyretics (fever reducers) and mentions an intravenous formulation of ibuprofen that was approved by the US-FDA for fever reduction in adults. Methylprednisolone is a corticosteroid used for its anti-inflammatory effects rather than for pain relief in clinical practice; therefore, it is unrelated to pain management in this context." -15610554,Methylprednisolone affects rheumatoid arthritis,53,"OBJECTIVES: This study compared the analgesic effectiveness of acetaminophen-codeine with that of ibuprofen for children with acute traumatic extremity pain, with the hypothesis that the two medications would demonstrate equivalent reduction in pain scores in an emergency department (ED) setting.",False,"Is the triple 'Methylprednisolone affects rheumatoid arthritis' supported by the sentence: 'OBJECTIVES: This study compared the analgesic effectiveness of acetaminophen-codeine with that of ibuprofen for children with acute traumatic extremity pain, with the hypothesis that the two medications would demonstrate equivalent reduction in pain scores in an emergency department (ED) setting.'?","No, the statement does not provide indirect support for the claim that ""Methylprednisolone affects rheumatoid arthritis."" The study mentioned in the statement investigates the analgesic effectiveness of acetaminophen-codeine versus ibuprofen in children suffering from acute traumatic extremity pain in an emergency department setting. There is no mention or implication of methylprednisolone or rheumatoid arthritis in the study objectives provided. Therefore, it does not offer any relevant context or evidence that could be used to infer methylprednisolone's impact on rheumatoid arthritis." -15186368,Methylprednisolone affects graft versus host disease,54,"Thus, the anti-inflammatory drug ibuprofen, which has been associated with reduced AD risk in human epidemiological studies, can significantly delay some forms of AD pathology, including amyloid deposition, when administered early in the disease course of a transgenic mouse model of AD.",False,"Is the triple 'Methylprednisolone affects graft versus host disease' supported by the sentence: 'Thus, the anti-inflammatory drug ibuprofen, which has been associated with reduced AD risk in human epidemiological studies, can significantly delay some forms of AD pathology, including amyloid deposition, when administered early in the disease course of a transgenic mouse model of AD.'?","No, the statement does not provide indirect support for the phrase ""Methylprednisolone affects graft versus host disease"". The statement discusses the effects of ibuprofen on Alzheimer's disease (AD) pathology in a transgenic mouse model, while the phrase pertains to Methylprednisolone's impact on graft versus host disease. These two subjects are unrelated in the context provided." -14891106,Methylprednisolone affects kidney disorder,55,"The hypoxia, hypertension and increased prostanoids were prevented using ibuprofen.",False,"Is the triple 'Methylprednisolone affects kidney disorder' supported by the sentence: 'The hypoxia, hypertension and increased prostanoids were prevented using ibuprofen.'?","No, the statement does not provide indirect support for the phrase ""Methylprednisolone affects kidney disorder"". The statement discusses the prevention of hypoxia, hypertension, and increased prostanoids using ibuprofen; however, it does not mention methylprednisolone or kidney disorder at all. To provide indirect support for the original phrase, there should be some connection between methylprednisolone, kidney disorder, and the factors mentioned in the statement (hypoxia, hypertension, increased prostanoids). Since no such connection is established in the given statement, it does not offer indirect support for the claim about methylprednisolone affecting kidney disorder." -11819955,Methylprednisolone affects spinal cord injury,56,"The Effect of Ibuprofen Dosing Interval on Post-Tonsillectomy Outcomes in Children: A Quality Improvement Study.OBJECTIVE: In this Quality Improvement (QI project) it was hypothesized that an increase in dosing intervals for postoperative analgesia when alternating Ibuprofen and Acetaminophen would reduce post-tonsillectomy hemorrhage (PTH) rates for those undergoing tonsillectomies with or without adenoidectomy, while maintaining the standard of postoperative analgesia and reducing visits to the Emergency Room (ER) for reasons other than PTH.",False,"Is the triple 'Methylprednisolone affects spinal cord injury' supported by the sentence: 'The Effect of Ibuprofen Dosing Interval on Post-Tonsillectomy Outcomes in Children: A Quality Improvement Study.OBJECTIVE: In this Quality Improvement (QI project) it was hypothesized that an increase in dosing intervals for postoperative analgesia when alternating Ibuprofen and Acetaminophen would reduce post-tonsillectomy hemorrhage (PTH) rates for those undergoing tonsillectomies with or without adenoidectomy, while maintaining the standard of postoperative analgesia and reducing visits to the Emergency Room (ER) for reasons other than PTH.'?","No, the statement does not provide any direct or indirect support for the claim that ""Methylprednisolone affects spinal cord injury."" The statement is about a Quality Improvement project examining the effect of Ibuprofen dosing intervals on post-tonsillectomy outcomes in children. The project does not mention Methylprednisolone nor spinal cord injuries at all, so it does not provide any relevant information concerning the effects of Methylprednisolone on spinal cord injuries." -10845505,Methylprednisolone affects Pain,57,Studies show that ibuprofen demonstrates superior efficacy in fever reduction compared to acetaminophen.,False,Is the triple 'Methylprednisolone affects Pain' supported by the sentence: 'Studies show that ibuprofen demonstrates superior efficacy in fever reduction compared to acetaminophen.'?,"No, the statement does not provide indirect support for the phrase ""Methylprednisolone affects Pain"". The statement compares the fever-reducing efficacy of ibuprofen and acetaminophen, which is not related to methylprednisolone or pain management. Methylprednisolone is a corticosteroid used primarily for its anti-inflammatory effects rather than pain reduction. While it might have some analgesic properties due to its anti-inflammatory action, it is not directly supported by the given statement about ibuprofen and acetaminophen in fever reduction." -10048898,Methylprednisolone affects ulcerative colitis,58,IV Ibuprofen for Prevention of Post-Ercp Pancreatitis in Children: A Randomized Placebo-Controlled Feasibility Study.,False,Is the triple 'Methylprednisolone affects ulcerative colitis' supported by the sentence: 'IV Ibuprofen for Prevention of Post-Ercp Pancreatitis in Children: A Randomized Placebo-Controlled Feasibility Study.'?,"No, the statement ""IV Ibuprofen for Prevention of Post-ERCP Pancreatitis in Children: A Randomized Placebo-Controlled Feasibility Study"" does not provide indirect support for the phrase ""Methylprednisolone affects ulcerative colitis."" The study focuses on using intravenous ibuprofen for preventing post-ERCP (Endoscopic Retrograde Cholangiopancreatography) pancreatitis in children; it does not involve methylprednisolone or ulcerative colitis in any way. Therefore, there is no connection between these two pieces of information that would allow for indirect support." -9646753,Methylprednisolone affects multiple sclerosis,59,Altitude Sickness Prevention with Ibuprofen Relative to Acetazolamide.,False,Is the triple 'Methylprednisolone affects multiple sclerosis' supported by the sentence: 'Altitude Sickness Prevention with Ibuprofen Relative to Acetazolamide.'?,"No, the statement ""Altitude Sickness Prevention with Ibuprofen Relative to Acetazolamide"" does not provide indirect support for the phrase ""Methylprednisolone affects multiple sclerosis."" - - The statement in question discusses altitude sickness prevention using Ibuprofen compared to Acetazolamide, which is unrelated to Multiple Sclerosis (MS) or Methylprednisolone. Methylprednisolone is a corticosteroid used in treating various conditions such as inflammation, allergic reactions, and MS relapses due to its immunosuppressive properties. - - While both Ibuprofen and Methylprednisolone have anti-inflammatory effects, they act through different mechanisms and have distinct therapeutic applications. Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) that inhibits cyclooxygenase (COX) enzymes involved in prostaglandin synthesis, whereas Methylprednisolone influences gene expression and suppresses immune cell function via gluc" -9346353,Methylprednisolone affects chronic obstructive pulmonary disease,60,"In conclusion, prednisone, ibuprofen and betamethasone may prevent OA by suppressing the expression of IL-6 and IL-8, subsequently inactivating NF-kappaB and STAT3 pathways, and ultimately, leading to decreased levels of collagen I, MMP-1, and MMP-13.",False,"Is the triple 'Methylprednisolone affects chronic obstructive pulmonary disease' supported by the sentence: 'In conclusion, prednisone, ibuprofen and betamethasone may prevent OA by suppressing the expression of IL-6 and IL-8, subsequently inactivating NF-kappaB and STAT3 pathways, and ultimately, leading to decreased levels of collagen I, MMP-1, and MMP-13.'?","No, the statement does not provide indirect support for the phrase ""Methylprednisolone affects chronic obstructive pulmonary disease"" (COPD). The statement discusses the effects of prednisone, ibuprofen, and betamethasone on osteoarthritis (OA) by suppressing specific pathways and decreasing levels of certain proteins involved in joint degradation. Methylprednisolone is not mentioned in the statement, nor is there any connection made between these medications/pathways/proteins and COPD. Therefore, it is inappropriate to infer any support for the given phrase based on this information alone." -9107378,Methylprednisolone affects Edema,61,"This study aims to determine the therapeutic effects of ibuprofen, diphenhydramine and aluminum magnesium simethicone (AlMgS) syrup on reducing oral aphthous ulcer pain.",False,"Is the triple 'Methylprednisolone affects Edema' supported by the sentence: 'This study aims to determine the therapeutic effects of ibuprofen, diphenhydramine and aluminum magnesium simethicone (AlMgS) syrup on reducing oral aphthous ulcer pain.'?","No, the statement does not provide indirect support for the claim that ""Methylprednisolone affects Edema"". The study mentioned is focused on determining the therapeutic effects of ibuprofen, diphenhydramine, and aluminum magnesium simethicone syrup on reducing oral aphthous ulcer pain. Methylprednisolone is not mentioned in the study aims, nor does it have any direct or indirect relation to ibuprofen, diphenhydramine, or aluminum magnesium simethicone syrup in terms of treating oral aphthous ulcers or reducing pain associated with them. Methylprednisolone is primarily used for its anti-inflammatory and immunosuppressive properties in various medical conditions, one of which is edema; however, this study does not investigate methylprednisolone or its effects on edema." -8596544,Methylprednisolone affects asthma,62,"CONCLUSIONS: Considering the results of the study, reflexology was superior to Ibuprofen on reducing dysmenorrhea and its treatment effect continued even after discontinuing the intervention in the third cycle.",False,"Is the triple 'Methylprednisolone affects asthma' supported by the sentence: 'CONCLUSIONS: Considering the results of the study, reflexology was superior to Ibuprofen on reducing dysmenorrhea and its treatment effect continued even after discontinuing the intervention in the third cycle.'?","No, the statement does not provide any indirect support for the claim that ""Methylprednisolone affects asthma."" The conclusion in the statement is about reflexology being superior to Ibuprofen in reducing dysmenorrhea, which is unrelated to Methylprednisolone or asthma treatment. The two statements involve different subjects (reflexology vs Methylprednisolone) and conditions (dysmenorrhea vs asthma), so there is no overlap that would allow for indirect support." -8330909,Methylprednisolone affects systemic lupus erythematosus,63,CONCLUSION: We conclude that pain therapy with an almost peripherally acting drug such as ibuprofen can reduce osteoporosis-associated chronic pain better than a centrally acting pain medication such as tramadol.,False,Is the triple 'Methylprednisolone affects systemic lupus erythematosus' supported by the sentence: 'CONCLUSION: We conclude that pain therapy with an almost peripherally acting drug such as ibuprofen can reduce osteoporosis-associated chronic pain better than a centrally acting pain medication such as tramadol.'?,"No, the conclusion does not provide indirect support for the statement that ""Methylprednisolone affects systemic lupus erythematosus"". The conclusion discusses the efficacy of two different types of pain medications (ibuprofen, a non-steroidal anti-inflammatory drug (NSAID), and tramadol, an opioid) in managing osteoporosis-associated chronic pain without mentioning methylprednisolone or systemic lupus erythematosus (SLE). Methylprednisolone is a corticosteroid used primarily for its potent anti-inflammatory effects in various diseases such as SLE but is not mentioned in the conclusion provided. Therefore, it does not offer any indirect support for the original statement about methylprednisolone affecting SLE." -19744632,Methylprednisolone disrupts Edema,64,The objective of this study was to determine whether pretreatment with ibuprofen would prevent the onset or decrease the severity of headache that occurs after ECT.,False,Is the triple 'Methylprednisolone disrupts Edema' supported by the sentence: 'The objective of this study was to determine whether pretreatment with ibuprofen would prevent the onset or decrease the severity of headache that occurs after ECT.'?,"No, the statement does not provide indirect support for the phrase ""Methylprednisolone disrupts Edema"". The study in question focuses on determining whether pretreatment with ibuprofen can prevent or decrease the severity of headaches following Electroconvulsive Therapy (ECT). Methylprednisolone is not mentioned in the statement at all, let alone in relation to edema disruption." -18407557,Methylprednisolone disrupts thrombocytopenia,65,The results of this study reveal that intake of ibuprofen can decrease muscle soreness induced after eccentric exercise but cannot assist in restoring muscle function.,False,Is the triple 'Methylprednisolone disrupts thrombocytopenia' supported by the sentence: 'The results of this study reveal that intake of ibuprofen can decrease muscle soreness induced after eccentric exercise but cannot assist in restoring muscle function.'?,"No, the statement does not provide indirect support for the phrase ""Methylprednisolone disrupts thrombocytopenia."" The study mentioned in the statement investigates the effects of ibuprofen on muscle soreness after exercise, not methylprednisolone or thrombocytopenia (a condition characterized by abnormally low levels of platelets in the blood). Therefore, the evidence provided does not pertain to methylprednisolone nor thrombocytopenia, making it irrelevant in supporting that claim. - - To provide indirect support for ""Methylprednisolone disrupts thrombocytopenia,"" one would need evidence suggesting that methylprednisolone has an impact on platelet function or levels in some capacity. This impact could either be positive (increasing platelet count) or negative (decreasing platelet count). However, without any reference or mention of methylprednisolone in the given statement, it cannot be used as indirect evidence for its effect on thrombocytopenia." -11106658,Methylprednisolone disrupts Pain,66,The objective of our study was to determine the role of ibuprofen in protecting neutropenic rats from cardiopulmonary injury due to endotoxemia.,False,Is the triple 'Methylprednisolone disrupts Pain' supported by the sentence: 'The objective of our study was to determine the role of ibuprofen in protecting neutropenic rats from cardiopulmonary injury due to endotoxemia.'?,"No, the statement does not provide indirect support for the phrase ""Methylprednisolone disrupts Pain."" The objective of the study mentioned is focused on investigating the protective effects of ibuprofen on neutropenic rats suffering from cardiopulmonary injury due to endotoxemia. Methylprednisolone is not mentioned in the statement; therefore, no conclusions can be drawn about its relationship with pain disruption based on this information alone." -8640603,Methylprednisolone disrupts Inflammation,67,"To determine if prophylactic etodolac would significantly reduce postendodontic pain, when compared with ibuprofen or placebo, 36 patients consented to single blind oral administration of either 400 mg of etodolac, 600 mg of ibuprofen, or a placebo, before conventional one-appointment root canal therapy.",False,"Is the triple 'Methylprednisolone disrupts Inflammation' supported by the sentence: 'To determine if prophylactic etodolac would significantly reduce postendodontic pain, when compared with ibuprofen or placebo, 36 patients consented to single blind oral administration of either 400 mg of etodolac, 600 mg of ibuprofen, or a placebo, before conventional one-appointment root canal therapy.'?","No, the statement does not provide indirect support for the phrase ""Methylprednisolone disrupts Inflammation"". The study mentioned in the statement investigates the effects of prophylactic etodolac, ibuprofen, and placebo on postendodontic pain but does not involve methylprednisolone. Therefore, it does not provide evidence or implications related to methylprednisolone disruption of inflammation." -23934495,Methylprednisolone prevents Cognitive impairment,68,UNLABELLED: The aim of our study was to evaluate whether the prophylactic use of ibuprofen would reduce the incidence of significant patent ductus arteriosus (PDA) and to confirm the effectiveness of ibuprofen as rescue treatment in closing PDA.,False,Is the triple 'Methylprednisolone prevents Cognitive impairment' supported by the sentence: 'UNLABELLED: The aim of our study was to evaluate whether the prophylactic use of ibuprofen would reduce the incidence of significant patent ductus arteriosus (PDA) and to confirm the effectiveness of ibuprofen as rescue treatment in closing PDA.'?,"No, the statement does not provide indirect support for the phrase ""Methylprednisolone prevents Cognitive impairment."" The focus of the study in the statement is on evaluating the prophylactic use of ibuprofen in reducing the incidence of significant patent ductus arteriosus (PDA) and its effectiveness as rescue treatment in closing PDA. Methylprednisolone is not mentioned in the study, so there is no basis for inferring any effect it may have on cognitive impairment." -20014108,Methylprednisolone prevents rheumatoid arthritis,69,"Nonsteroidal anti-inflammatory drugs (NSAIDs) such as aspirin, indomethacin and ibuprofen are the most widely used drugs for pain, arthritis, cardiovascular diseases and, more recently, the prevention of colon cancer and Alzheimer disease.",False,"Is the triple 'Methylprednisolone prevents rheumatoid arthritis' supported by the sentence: 'Nonsteroidal anti-inflammatory drugs (NSAIDs) such as aspirin, indomethacin and ibuprofen are the most widely used drugs for pain, arthritis, cardiovascular diseases and, more recently, the prevention of colon cancer and Alzheimer disease.'?","No, the statement does not provide indirect support for the phrase ""Methylprednisolone prevents rheumatoid arthritis"". The statement discusses Nonsteroidal anti-inflammatory drugs (NSAIDs) such as aspirin, indomethacin, and ibuprofen, which have a different mechanism of action and therapeutic effects compared to Methylprednisolone, a corticosteroid used for its anti-inflammatory and immunosuppressive effects in various conditions including rheumatoid arthritis treatment. While both NSAIDs and Methylprednisolone can be used in treating arthritis symptoms, they differ in their disease-modifying abilities and long-term effects on rheumatoid arthritis prevention." -18266414,Methylprednisolone prevents Abdominal pain,70,Aggravation of seizure-associated microvascular injuries by ibuprofen may involve multiple pathways.,False,Is the triple 'Methylprednisolone prevents Abdominal pain' supported by the sentence: 'Aggravation of seizure-associated microvascular injuries by ibuprofen may involve multiple pathways.'?,"No, the statement ""Aggravation of seizure-associated microvascular injuries by ibuprofen may involve multiple pathways"" does not provide indirect support for the claim that ""Methylprednisolone prevents Abdominal pain."" + To further elaborate on why there is no indirect support, consider that indirect support typically involves related concepts, shared underlying mechanisms, or similar study designs/results that can be extrapolated between two studies/claims. In this case, however, there is no such connection between IV Ibuprofen's potential impact on post-ERCP pancreatitis in children and Methylprednisolone's effect on ulcerative colitis." +9646753,Methylprednisolone affects multiple sclerosis,59,Altitude Sickness Prevention with Ibuprofen Relative to Acetazolamide.,False,"'Does the phrase ""Methylprednisolone affects multiple sclerosis"" receive at least indirect support from the statement: ""Altitude Sickness Prevention with Ibuprofen Relative to Acetazolamide.""?","No, the statement ""Altitude Sickness Prevention with Ibuprofen Relative to Acetazolamide"" does not provide indirect support for the phrase ""Methylprednisolone affects multiple sclerosis."" - + The reason is that these two statements discuss different medical conditions (altitude sickness and multiple sclerosis) and different therapeutic agents (Ibuprofen/Acetazolamide and Methylprednisolone). There is no common ground between these statements in terms of disease condition or drug mechanism that would allow for indirect support to be inferred. - The two statements discuss different subjects: one focuses on methylprednisolone potentially preventing abdominal pain, while the other discusses ibuprofen potentially exacerbating seizure-associated microvascular injuries through various pathways. + Methylprednisolone is a corticosteroid often used in treating multiple sclerosis due to its anti-inflammatory effects, while Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) used for pain relief in various conditions including altitude sickness, and Acetazolamide is a medication used for preventing altitude sickness by reducing the body's production of acidic fluids. - + Therefore, any evaluation of the effect of Methylprednis" +9346353,Methylprednisolone affects chronic obstructive pulmonary disease,60,"In conclusion, prednisone, ibuprofen and betamethasone may prevent OA by suppressing the expression of IL-6 and IL-8, subsequently inactivating NF-kappaB and STAT3 pathways, and ultimately, leading to decreased levels of collagen I, MMP-1, and MMP-13.",False,"'Does the phrase ""Methylprednisolone affects chronic obstructive pulmonary disease"" receive at least indirect support from the statement: ""In conclusion, prednisone, ibuprofen and betamethasone may prevent OA by suppressing the expression of IL-6 and IL-8, subsequently inactivating NF-kappaB and STAT3 pathways, and ultimately, leading to decreased levels of collagen I, MMP-1, and MMP-13.""?","No, the statement does not provide indirect support for the phrase ""Methylprednisolone affects chronic obstructive pulmonary disease"" (COPD). The statement discusses the effects of prednisone, ibuprofen, and betamethasone on osteoarthritis (OA) by suppressing certain pathways related to inflammation (IL-6 and IL-8) and collagen degradation (MMP-1 and MMP-13). Methylprednisolone is not mentioned in the statement at all, let alone its potential effects on COPD. - The provided statement about ibuprofen does not mention methylprednisolone nor abdominal pain; therefore, it does not contribute any evidence for or against that claim. + However, it is important to note that both COPD and OA involve inflammation, so there may be some overlap in terms of potential therapeutic agents that target inflammation. Nonetheless, without specific information about methylprednisolone's effects on COPD, it would be inappropriate to make any assumptions about its potential therapeutic benefits in COPD based on the provided statement alone." +9107378,Methylprednisolone affects Edema,61,"This study aims to determine the therapeutic effects of ibuprofen, diphenhydramine and aluminum magnesium simethicone (AlMgS) syrup on reducing oral aphthous ulcer pain.",False,"'Does the phrase ""Methylprednisolone affects Edema"" receive at least indirect support from the statement: ""This study aims to determine the therapeutic effects of ibuprofen, diphenhydramine and aluminum magnesium simethicone (AlMgS) syrup on reducing oral aphthous ulcer pain.""?","No, the statement does not provide indirect support for the phrase ""Methylprednisolone affects Edema"". The study mentioned is focused on determining the therapeutic effects of ibuprofen, diphenhydramine and aluminum magnesium simethicone syrup on reducing oral aphthous ulcer pain. Methylprednisolone is not mentioned in the study aim, nor does it have any direct or indirect connection to ibuprofen, diphenhydramine or aluminum magnesium simethicone syrup. Methylprednisolone is a corticosteroid often used to reduce inflammation and edema in various clinical conditions, but the statement provided does not offer any information or implications regarding its effects on edema." +8596544,Methylprednisolone affects asthma,62,"CONCLUSIONS: Considering the results of the study, reflexology was superior to Ibuprofen on reducing dysmenorrhea and its treatment effect continued even after discontinuing the intervention in the third cycle.",False,"'Does the phrase ""Methylprednisolone affects asthma"" receive at least indirect support from the statement: ""CONCLUSIONS: Considering the results of the study, reflexology was superior to Ibuprofen on reducing dysmenorrhea and its treatment effect continued even after discontinuing the intervention in the third cycle.""?","No, the statement does not provide indirect support for the phrase ""Methylprednisolone affects asthma."" The conclusion in the statement is about reflexology being superior to Ibuprofen in reducing dysmenorrhea, which is unrelated to Methylprednisolone or asthma. Methylprednisolone is a corticosteroid used for its anti-inflammatory effects in various conditions such as asthma, but no such claim is made in the provided statement." +8330909,Methylprednisolone affects systemic lupus erythematosus,63,CONCLUSION: We conclude that pain therapy with an almost peripherally acting drug such as ibuprofen can reduce osteoporosis-associated chronic pain better than a centrally acting pain medication such as tramadol.,False,"'Does the phrase ""Methylprednisolone affects systemic lupus erythematosus"" receive at least indirect support from the statement: ""CONCLUSION: We conclude that pain therapy with an almost peripherally acting drug such as ibuprofen can reduce osteoporosis-associated chronic pain better than a centrally acting pain medication such as tramadol.""?","No, the statement does not provide indirect support for the phrase ""Methylprednisolone affects systemic lupus erythematosus."" The conclusion is about pain therapy using ibuprofen versus tramadol in osteoporosis-associated chronic pain management. Methylprednisolone is not mentioned in either the conclusion itself nor in its comparison of ibuprofen (a non-steroidal anti-inflammatory drug) and tramadol (an opioid analgesic). - + Systemic lupus erythematosus (SLE) is an autoimmune disease affecting multiple organs in the body, whereas osteoporosis is characterized by weakened bones due to loss of bone density. Methylprednisolone is indeed used in treating SLE due to its anti-inflammatory effects; however, that is beyond the scope of the provided conclusion about pain therapies for osteoporosis-associated chronic pain." +19744632,Methylprednisolone disrupts Edema,64,The objective of this study was to determine whether pretreatment with ibuprofen would prevent the onset or decrease the severity of headache that occurs after ECT.,False,"'Does the phrase ""Methylprednisolone disrupts Edema"" receive at least indirect support from the statement: ""The objective of this study was to determine whether pretreatment with ibuprofen would prevent the onset or decrease the severity of headache that occurs after ECT.""?","No, the statement does not provide indirect support for the phrase ""Methylprednisolone disrupts Edema"". The study in question focuses on determining whether pretreatment with ibuprofen can prevent or decrease the severity of headaches following Electroconvulsive Therapy (ECT). Methylprednisolone is not mentioned in the statement at all, let alone its potential effect on edema. Edema is also not addressed in the statement. Therefore, there is no indirect support for the phrase based on this information alone." +18407557,Methylprednisolone disrupts thrombocytopenia,65,The results of this study reveal that intake of ibuprofen can decrease muscle soreness induced after eccentric exercise but cannot assist in restoring muscle function.,False,"'Does the phrase ""Methylprednisolone disrupts thrombocytopenia"" receive at least indirect support from the statement: ""The results of this study reveal that intake of ibuprofen can decrease muscle soreness induced after eccentric exercise but cannot assist in restoring muscle function.""?","No, the statement does not provide indirect support for the phrase ""Methylprednisolone disrupts thrombocytopenia"". + + The statement discusses the effects of ibuprofen on muscle soreness and function after exercise, while the phrase in question pertains to Methylprednisolone's impact on thrombocytopenia, which is a condition characterized by abnormally low levels of platelets in the blood. + + Thrombocytopenia can be caused by various factors including certain medications, infections, immune system disorders, and pregnancy complications among others. Methylprednisolone is a type of corticosteroid often used in treatment regimens for thrombocytopenia due to its anti-inflammatory properties and ability to suppress immune response. - To establish indirect support for the claim about methylprednisolone preventing abdominal pain, we would need evidence connecting ibuprofen usage (or another factor related to abdominal pain) with methylprednisolone treatment in some way that would suggest one affects the other. Since there is no such connection in the provided statement, it does not offer indirect support for the initial claim." -14967074,Methylprednisolone prevents asthma,71,"Use of paracetamol, ibuprofen or aspirin in pregnancy and risk of cerebral palsy in the child.",False,"Is the triple 'Methylprednisolone prevents asthma' supported by the sentence: 'Use of paracetamol, ibuprofen or aspirin in pregnancy and risk of cerebral palsy in the child.'?","No, the statement ""Methylprednisolone prevents asthma"" does not receive indirect support from ""Use of paracetamol, ibuprofen or aspirin in pregnancy and risk of cerebral palsy in the child."" + Therefore, although both statements discuss medical treatments (ibuprofen and methylprednisolone), they refer to different conditions (muscle soreness/function vs thrombocytopenia) and thus cannot be interpreted as indirectly supporting each other." +11106658,Methylprednisolone disrupts Pain,66,The objective of our study was to determine the role of ibuprofen in protecting neutropenic rats from cardiopulmonary injury due to endotoxemia.,False,"'Does the phrase ""Methylprednisolone disrupts Pain"" receive at least indirect support from the statement: ""The objective of our study was to determine the role of ibuprofen in protecting neutropenic rats from cardiopulmonary injury due to endotoxemia.""?","No, the statement does not provide indirect support for the phrase ""Methylprednisolone disrupts Pain"". - These two statements discuss entirely different subjects: one pertains to methylprednisolone as a preventative treatment for asthma, while the other discusses medication use during pregnancy and its potential impact on cerebral palsy risk in offspring. There is no overlap in terms of shared variables, concepts, or mechanisms that would allow for indirect support from one statement to be drawn from the other in any meaningful way. + The statement is about a study that aims to investigate the protective effects of ibuprofen on neutropenic rats from cardiopulmonary injury due to endotoxemia. There is no mention of methylprednisolone in this statement, let alone any disruption of pain. Methylprednisolone is a type of corticosteroid often used for its anti-inflammatory and immunosuppressive effects, unrelated to the objectives of the study mentioned in the statement. Therefore, it is not reasonable to infer any relationship between methylprednisolone and pain disruption from this statement." +8640603,Methylprednisolone disrupts Inflammation,67,"To determine if prophylactic etodolac would significantly reduce postendodontic pain, when compared with ibuprofen or placebo, 36 patients consented to single blind oral administration of either 400 mg of etodolac, 600 mg of ibuprofen, or a placebo, before conventional one-appointment root canal therapy.",False,"'Does the phrase ""Methylprednisolone disrupts Inflammation"" receive at least indirect support from the statement: ""To determine if prophylactic etodolac would significantly reduce postendodontic pain, when compared with ibuprofen or placebo, 36 patients consented to single blind oral administration of either 400 mg of etodolac, 600 mg of ibuprofen, or a placebo, before conventional one-appointment root canal therapy.""?","No, the statement does not provide indirect support for the phrase ""Methylprednisolone disrupts Inflammation."" The statement discusses an experiment investigating the effect of prophylactic etodolac on postendodontic pain in comparison to ibuprofen and placebo before conventional one-appointment root canal therapy. Methylprednisolone is not mentioned in the statement; therefore, it does not offer any support for the claim about Methylprednisolone disrupting inflammation." +23934495,Methylprednisolone prevents Cognitive impairment,68,UNLABELLED: The aim of our study was to evaluate whether the prophylactic use of ibuprofen would reduce the incidence of significant patent ductus arteriosus (PDA) and to confirm the effectiveness of ibuprofen as rescue treatment in closing PDA.,False,"'Does the phrase ""Methylprednisolone prevents Cognitive impairment"" receive at least indirect support from the statement: ""UNLABELLED: The aim of our study was to evaluate whether the prophylactic use of ibuprofen would reduce the incidence of significant patent ductus arteriosus (PDA) and to confirm the effectiveness of ibuprofen as rescue treatment in closing PDA.""?","No, the statement does not provide indirect support for the phrase ""Methylprednisolone prevents Cognitive impairment."" The aim of the study as described in the statement is to evaluate the effectiveness of ibuprofen in preventing and treating patent ductus arteriosus (PDA), which is a condition related to heart function in newborns. There is no mention of methylprednisolone in the statement nor any reference made to cognitive impairment prevention. Therefore, it does not provide indirect support for the stated phrase." +20014108,Methylprednisolone prevents rheumatoid arthritis,69,"Nonsteroidal anti-inflammatory drugs (NSAIDs) such as aspirin, indomethacin and ibuprofen are the most widely used drugs for pain, arthritis, cardiovascular diseases and, more recently, the prevention of colon cancer and Alzheimer disease.",False,"'Does the phrase ""Methylprednisolone prevents rheumatoid arthritis"" receive at least indirect support from the statement: ""Nonsteroidal anti-inflammatory drugs (NSAIDs) such as aspirin, indomethacin and ibuprofen are the most widely used drugs for pain, arthritis, cardiovascular diseases and, more recently, the prevention of colon cancer and Alzheimer disease.""?","No, the statement does not provide indirect support for the phrase ""Methylprednisolone prevents rheumatoid arthritis"". The statement discusses the use of nonsteroidal anti-inflammatory drugs (NSAIDs) in preventing various conditions including colon cancer, Alzheimer disease, pain, arthritis, and cardiovascular diseases. Methylprednisolone is a corticosteroid drug that has anti-inflammatory actions but it is not an NSAID. The two classes of drugs have different mechanisms of action and side effect profiles. Therefore, the statement does not provide any evidence or reasoning that would suggest methylprednisolone prevents rheumatoid arthritis." +18266414,Methylprednisolone prevents Abdominal pain,70,Aggravation of seizure-associated microvascular injuries by ibuprofen may involve multiple pathways.,False,"'Does the phrase ""Methylprednisolone prevents Abdominal pain"" receive at least indirect support from the statement: ""Aggravation of seizure-associated microvascular injuries by ibuprofen may involve multiple pathways.""?","No, the statement does not provide indirect support for the phrase ""Methylprednisolone prevents Abdominal pain."" The two statements discuss different subjects: one is about methylprednisolone potentially preventing abdominal pain, while the other is about ibuprofen exacerbating seizure-associated microvascular injuries through multiple pathways. There is no connection between these two ideas that would allow us to infer support for methylprednisolone preventing abdominal pain based on the statement about ibuprofen." +14967074,Methylprednisolone prevents asthma,71,"Use of paracetamol, ibuprofen or aspirin in pregnancy and risk of cerebral palsy in the child.",False,"'Does the phrase ""Methylprednisolone prevents asthma"" receive at least indirect support from the statement: ""Use of paracetamol, ibuprofen or aspirin in pregnancy and risk of cerebral palsy in the child.""?","No, the statement ""Use of paracetamol, ibuprofen or aspirin in pregnancy and risk of cerebral palsy in the child"" does not provide indirect support for the phrase ""Methylprednisolone prevents asthma."" - In order for there to be indirect support between these two statements, there would need to be some connection in terms of shared factors such as an implicated biological pathway, common risk factors, demonstrated efficacy in similar patient populations, etc., but none exists here based on the information provided." -9744990,Methylprednisolone prevents ovarian hyperstimulation syndrome,72,"More than two cycles of ibuprofen was significantly associated with an increased risk for bronchopulmonary dysplasia (odds ratio [OR], 2.81; p = 0.03) and acute renal failure (OR, 3.81; p = 0.09).",False,"Is the triple 'Methylprednisolone prevents ovarian hyperstimulation syndrome' supported by the sentence: 'More than two cycles of ibuprofen was significantly associated with an increased risk for bronchopulmonary dysplasia (odds ratio [OR], 2.81; p = 0.03) and acute renal failure (OR, 3.81; p = 0.09).'?","No, the statement does not provide indirect support for the claim that methylprednisolone prevents ovarian hyperstimulation syndrome (OHSS). The statement discusses the association between repeated cycles of ibuprofen use in infants and an increased risk for bronchopulmonary dysplasia and acute renal failure. There is no mention of methylprednisolone or ovarian hyperstimulation syndrome in this statement. In order for there to be indirect support for the claim about methylprednisolone preventing OHSS, there would need to be some connection between methylprednisolone, ibuprofen, or their respective effects on ovarian hyperstimulation syndrome or bronchopulmonary dysplasia/acute renal failure, but no such connection is evident in this statement." -8345063,Methylprednisolone prevents Pain,73,OBJECTIVE: Non-steroidal anti-inflammatory drugs such as ibuprofen have a protective role on risk of Alzheimer's disease (AD).,False,Is the triple 'Methylprednisolone prevents Pain' supported by the sentence: 'OBJECTIVE: Non-steroidal anti-inflammatory drugs such as ibuprofen have a protective role on risk of Alzheimer's disease (AD).'?,"No, the statement does not provide indirect support for the phrase ""Methylprednisolone prevents Pain"". The objective in question discusses non-steroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen, having a protective role against Alzheimer's disease (AD). Methylprednisolone is a glucocorticoid steroid medication used primarily for its anti-inflammatory effects in various conditions; however, it is not classified as an NSAID nor is there any mention of pain prevention in the provided statement. + The two statements discuss different subjects: one is about anti-inflammatory drug use during pregnancy and its association with cerebral palsy in offspring, while the other is about methylprednisolone as a preventative measure for asthma. While methylprednisolone is also an anti-inflammatory drug, the statement about its potential for preventing asthma would require separate clinical evidence demonstrating its efficacy for that specific purpose. - To provide indirect support for ""Methylprednisolone prevents Pain"", one would need a statement linking methylprednisolone to pain prevention through its anti-inflammatory properties or some other mechanism. The lack of connection between methylprednisolone and pain prevention in the given statement makes it an unsuitable basis for inferring support for that phrase." -8291272,Methylprednisolone prevents graft versus host disease,74,"There seems to be a marked gradient of risk for acute kidney injury across agents, specifically for indomethacin, ibuprofen, and rofecoxib.",False,"Is the triple 'Methylprednisolone prevents graft versus host disease' supported by the sentence: 'There seems to be a marked gradient of risk for acute kidney injury across agents, specifically for indomethacin, ibuprofen, and rofecoxib.'?","No, the statement does not provide indirect support for the phrase ""Methylprednisolone prevents graft versus host disease."" The statement discusses the risk gradient for acute kidney injury across different non-steroidal anti-inflammatory drugs (NSAIDs) such as indomethacin, ibuprofen, and rofecoxib. Methylprednisolone is a corticosteroid and not an NSAID; therefore, it is not relevant to the discussion of NSAID-induced kidney injury risk. The statement does not mention graft versus host disease (GvHD) at all; thus, it does not provide any support for the claim that methylprednisolone prevents GvHD." -7980138,Methylprednisolone prevents spinal cord injury,75,"Significant heterogeneity was present for the NSAIDs; e.g., ibuprofen was associated with an increased overall fracture risk (OR = 2.09, 95% CI 2.00-2.18 for <20 DDD), while celecoxib was not (OR = 0.76, 95% CI 0.51-1.13 for <20 DDD, 2P < 0.01 for comparison).",False,"Is the triple 'Methylprednisolone prevents spinal cord injury' supported by the sentence: 'Significant heterogeneity was present for the NSAIDs; e.g., ibuprofen was associated with an increased overall fracture risk (OR = 2.09, 95% CI 2.00-2.18 for <20 DDD), while celecoxib was not (OR = 0.76, 95% CI 0.51-1.13 for <20 DDD, 2P < 0.01 for comparison).'?","No, the statement does not provide indirect support for the phrase ""Methylprednisolone prevents spinal cord injury"". The provided information discusses the relationship between nonsteroidal anti-inflammatory drugs (NSAIDs), specifically ibuprofen and celecoxib, and overall fracture risk. Methylprednisolone is a corticosteroid drug used primarily for its anti-inflammatory effects in various medical conditions; it is different from NSAIDs in terms of its mechanism of action and side effects profile. + The connection between these two statements is tenuous at best because they discuss different conditions (pregnancy complications vs asthma) and do not share common outcomes (cerebral palsy vs prevention of asthma). Therefore, it is not appropriate to infer support for one statement based on the other without additional information linking methylprednisolone use and asthma prevention specifically." +9744990,Methylprednisolone prevents ovarian hyperstimulation syndrome,72,"More than two cycles of ibuprofen was significantly associated with an increased risk for bronchopulmonary dysplasia (odds ratio [OR], 2.81; p = 0.03) and acute renal failure (OR, 3.81; p = 0.09).",False,"'Does the phrase ""Methylprednisolone prevents ovarian hyperstimulation syndrome"" receive at least indirect support from the statement: ""More than two cycles of ibuprofen was significantly associated with an increased risk for bronchopulmonary dysplasia (odds ratio [OR], 2.81; p = 0.03) and acute renal failure (OR, 3.81; p = 0.09).""?","No, the statement does not provide indirect support for the phrase ""Methylprednisolone prevents ovarian hyperstimulation syndrome"". The statement discusses the association between repeated cycles of ibuprofen use and increased risks for bronchopulmonary dysplasia and acute renal failure in newborns. It does not mention methylprednisolone or ovarian hyperstimulation syndrome at all. In order for there to be indirect support, there should be some connection between the two statements in terms of shared concepts, mechanisms, or outcomes. However, in this case, there is no such connection." +8345063,Methylprednisolone prevents Pain,73,OBJECTIVE: Non-steroidal anti-inflammatory drugs such as ibuprofen have a protective role on risk of Alzheimer's disease (AD).,False,"'Does the phrase ""Methylprednisolone prevents Pain"" receive at least indirect support from the statement: ""OBJECTIVE: Non-steroidal anti-inflammatory drugs such as ibuprofen have a protective role on risk of Alzheimer's disease (AD).""?","No, the statement does not provide indirect support for the phrase ""Methylprednisolone prevents Pain"". The objective in the statement is focused on non-steroidal anti-inflammatory drugs (NSAIDs) like ibuprofen having a protective role against Alzheimer's disease (AD). Methylprednisolone is a corticosteroid, not an NSAID, and its primary use is for reducing inflammation and suppressing the immune system rather than preventing pain specifically. Therefore, there is no clear connection between the two statements in terms of supporting the claim about Methylprednisolone preventing pain." +8291272,Methylprednisolone prevents graft versus host disease,74,"There seems to be a marked gradient of risk for acute kidney injury across agents, specifically for indomethacin, ibuprofen, and rofecoxib.",False,"'Does the phrase ""Methylprednisolone prevents graft versus host disease"" receive at least indirect support from the statement: ""There seems to be a marked gradient of risk for acute kidney injury across agents, specifically for indomethacin, ibuprofen, and rofecoxib.""?","No, the statement does not provide indirect support for the phrase ""Methylprednisolone prevents graft versus host disease."" The statement discusses acute kidney injury risks associated with different non-steroidal anti-inflammatory drugs (NSAIDs) such as indomethacin, ibuprofen, and rofecoxib but does not mention methylprednisolone nor graft versus host disease (GVHD). Methylprednisolone is a corticosteroid often used in treating GVHD; however, no connection is drawn between NSAIDs and GVHD prevention in either statement. Therefore, there is no indirect support for the initial phrase based on the provided statement." +7980138,Methylprednisolone prevents spinal cord injury,75,"Significant heterogeneity was present for the NSAIDs; e.g., ibuprofen was associated with an increased overall fracture risk (OR = 2.09, 95% CI 2.00-2.18 for <20 DDD), while celecoxib was not (OR = 0.76, 95% CI 0.51-1.13 for <20 DDD, 2P < 0.01 for comparison).",False,"'Does the phrase ""Methylprednisolone prevents spinal cord injury"" receive at least indirect support from the statement: ""Significant heterogeneity was present for the NSAIDs; e.g., ibuprofen was associated with an increased overall fracture risk (OR = 2.09, 95% CI 2.00-2.18 for <20 DDD), while celecoxib was not (OR = 0.76, 95% CI 0.51-1.13 for <20 DDD, 2P < 0.01 for comparison).""?","No, the statement does not provide indirect support for the phrase ""Methylprednisolone prevents spinal cord injury."" The statement discusses the effects of non-steroidal anti-inflammatory drugs (NSAIDs), specifically ibuprofen and celecoxib, on overall fracture risk. Methylprednisolone is a corticosteroid drug and not an NSAID, thus it is not included in the comparison. Therefore, any potential impact of methylprednisolone on spinal cord injury prevention is not addressed in this statement." +7414405,Methylprednisolone prevents Edema,76,One should be more critical about ivabradine and low-dose digoxin in diastolic heart failure.,False,"'Does the phrase ""Methylprednisolone prevents Edema"" receive at least indirect support from the statement: ""One should be more critical about ivabradine and low-dose digoxin in diastolic heart failure.""?","No, the statement ""One should be more critical about ivabradine and low-dose digoxin in diastolic heart failure"" does not provide indirect support for the phrase ""Methylprednisolone prevents Edema"". - The two statements discuss different drugs and different outcomes (spinal cord injury vs fracture risk), so they do not provide any relevant information supporting or contradicting each other. In order for there to be indirect support between these two statements, they would need to share some commonalities in terms of drug class, mechanism of action, study design, population, or outcome measure; however, that is not the case here. + The statement is about being more critical when considering ivabradine and low-dose digoxin for diastolic heart failure. It does not mention methylprednisolone or edema at all. Therefore, it does not provide any form of support for the claim that methylprednisolone prevents edema. - To assess whether methylprednisolone prevents spinal cord injury, one would need to examine studies specifically investigating its effects in spinal cord injury models, ideally through randomized controlled trials or" -7414405,Methylprednisolone prevents Edema,76,One should be more critical about ivabradine and low-dose digoxin in diastolic heart failure.,False,Is the triple 'Methylprednisolone prevents Edema' supported by the sentence: 'One should be more critical about ivabradine and low-dose digoxin in diastolic heart failure.'?,"No, the statement ""One should be more critical about ivabradine and low-dose digoxin in diastolic heart failure"" does not provide indirect support for the claim that ""Methylprednisolone prevents Edema."" + The two statements are on completely different topics. The first statement is about two specific treatments for heart failure, while the second statement is about a drug for preventing swelling (edema). Therefore, without additional information linking these two topics, it is not valid to infer support for one from the other." +18106042,Methylprednisolone predisposes pneumonia,77,"Preclinical studies of ivabradine in animal models with induced AF demonstrated a reduction in HR, with no significant worsening of QT interval or mean arterial pressure.",False,"'Does the phrase ""Methylprednisolone predisposes pneumonia"" receive at least indirect support from the statement: ""Preclinical studies of ivabradine in animal models with induced AF demonstrated a reduction in HR, with no significant worsening of QT interval or mean arterial pressure.""?","No, the statement does not provide indirect support for the phrase ""Methylprednisolone predisposes pneumonia."" The statement discusses preclinical studies of ivabradine in animal models with atrial fibrillation (AF), which showed a reduction in heart rate (HR) without significant changes in QT interval or mean arterial pressure. This information is not related to Methylprednisolone or its potential effects on pneumonia risk." +9645180,Methylprednisolone predisposes Inflammation,78,"In this review, we summarize the current knowledge of the HCN4 channel and ivabradine, including the function of HCN4 in cardiac pacemaking, the mechanism of action of If inhibition by ivabradine, and the pharmacological and clinical effects of ivabradine in cardiac diseases as HF, coronary artery disease, and atrial fibrillation.",False,"'Does the phrase ""Methylprednisolone predisposes Inflammation"" receive at least indirect support from the statement: ""In this review, we summarize the current knowledge of the HCN4 channel and ivabradine, including the function of HCN4 in cardiac pacemaking, the mechanism of action of If inhibition by ivabradine, and the pharmacological and clinical effects of ivabradine in cardiac diseases as HF, coronary artery disease, and atrial fibrillation.""?","No, the statement does not provide any direct or indirect support for the phrase ""Methylprednisolone predisposes Inflammation."" The statement is a review of the HCN4 channel and ivabradine, its function in cardiac pacemaking, its mechanism of action, and pharmacological and clinical effects in various cardiac diseases. There is no mention or implication of methylprednisolone or inflammation in the statement." +12905337,Cefotaxime related to Sepsis,79,Small studies have recently investigated the role of ivabradine in MS in sinus rhythm.,False,"'Does the phrase ""Cefotaxime related to Sepsis"" receive at least indirect support from the statement: ""Small studies have recently investigated the role of ivabradine in MS in sinus rhythm.""?","No, the statement ""Small studies have recently investigated the role of ivabradine in MS in sinus rhythm"" does not provide indirect support for the phrase ""Cefotaxime related to Sepsis"". - The two statements discuss different drugs (Methylprednisolone vs ivabradine and low-dose digoxin) and their potential effects on different conditions (Edema vs diastolic heart failure). The second statement is cautioning against using certain medications for diastolic heart failure without being overly critical, but it does not imply that Methylprednisolone is effective in preventing Edema. + The two statements are unrelated as they discuss different subjects. The first statement refers to small studies investigating ivabradine's role in Multiple Sclerosis (MS) for patients in sinus rhythm. Ivabradine is a medication used primarily for heart rate control in certain conditions, not an antibiotic like Cefotaxime. The second phrase discusses Cefotaxime, an antibiotic commonly used for treating various bacterial infections, and its potential relation to sepsis, which is a serious condition caused by the body's response to an infection. - To provide indirect support, there should be some connection between the two statements in terms of shared concepts or ideas that would allow one statement to lend credence to another. In this case, there is no such connection between Methylprednisolone and Edema on one hand, and ivabradine, low-dose digoxin, and diastolic heart failure on the other hand." -18106042,Methylprednisolone predisposes pneumonia,77,"Preclinical studies of ivabradine in animal models with induced AF demonstrated a reduction in HR, with no significant worsening of QT interval or mean arterial pressure.",False,"Is the triple 'Methylprednisolone predisposes pneumonia' supported by the sentence: 'Preclinical studies of ivabradine in animal models with induced AF demonstrated a reduction in HR, with no significant worsening of QT interval or mean arterial pressure.'?","No, the statement does not provide indirect support for the phrase ""Methylprednisolone predisposes pneumonia."" The statement discusses preclinical studies on ivabradine, its effects on heart rate (HR), QT interval, and mean arterial pressure in animal models with atrial fibrillation (AF). There is no mention of methylprednisolone or pneumonia in the statement, making it unrelated to the claim in question." -9645180,Methylprednisolone predisposes Inflammation,78,"In this review, we summarize the current knowledge of the HCN4 channel and ivabradine, including the function of HCN4 in cardiac pacemaking, the mechanism of action of If inhibition by ivabradine, and the pharmacological and clinical effects of ivabradine in cardiac diseases as HF, coronary artery disease, and atrial fibrillation.",False,"Is the triple 'Methylprednisolone predisposes Inflammation' supported by the sentence: 'In this review, we summarize the current knowledge of the HCN4 channel and ivabradine, including the function of HCN4 in cardiac pacemaking, the mechanism of action of If inhibition by ivabradine, and the pharmacological and clinical effects of ivabradine in cardiac diseases as HF, coronary artery disease, and atrial fibrillation.'?","No, the statement does not provide any direct or indirect support for the phrase ""Methylprednisolone predisposes Inflammation."" The statement is a review on the HCN4 channel, its function in cardiac pacemaking, the mechanism of action of If inhibition by ivabradine, and the pharmacological and clinical effects of ivabradine in certain cardiac diseases. It does not mention Methylprednisolone or its potential relationship with inflammation." -12905337,Cefotaxime related to Sepsis,79,Small studies have recently investigated the role of ivabradine in MS in sinus rhythm.,False,Is the triple 'Cefotaxime related to Sepsis' supported by the sentence: 'Small studies have recently investigated the role of ivabradine in MS in sinus rhythm.'?,"No, the statement ""Small studies have recently investigated the role of ivabradine in MS in sinus rhythm"" does not provide any direct or indirect support for the phrase ""Cefotaxime related to Sepsis"". + Therefore, these statements discuss different medications, conditions, and areas of study, making it impossible for one to indirectly support the other." +24475300,Cefotaxime affects bacterial infectious disease,80,The role of Ivabradine in Diastolic Heart Failure with preserved Ejection Fraction.,False,"'Does the phrase ""Cefotaxime affects bacterial infectious disease"" receive at least indirect support from the statement: ""The role of Ivabradine in Diastolic Heart Failure with preserved Ejection Fraction.""?","No, the statement ""The role of Ivabradine in Diastolic Heart Failure with preserved Ejection Fraction"" does not provide indirect support for the phrase ""Cefotaxime affects bacterial infectious disease."" - The two statements discuss different subjects: one is about ivabradine's potential role in treating Multiple Sclerosis (MS) in sinus rhythm, while the other connects Cefotaxime with sepsis. There is no overlap in terms of substances, conditions, or concepts that would allow for indirect support to be inferred. + The reason is that these two statements discuss different topics altogether. The first statement refers to Ivabradine's role in diastolic heart failure with preserved ejection fraction, which is a cardiovascular condition in humans. On the other hand, Cefotaxime is an antibiotic used for treating bacterial infections, as suggested by the second phrase. - To establish a connection between Cefotaxime and sepsis, one could look at existing literature on antibiotics like Cefotaxime and their association with sepsis, but that would require separate evidence beyond what was provided in your question." -24475300,Cefotaxime affects bacterial infectious disease,80,The role of Ivabradine in Diastolic Heart Failure with preserved Ejection Fraction.,False,Is the triple 'Cefotaxime affects bacterial infectious disease' supported by the sentence: 'The role of Ivabradine in Diastolic Heart Failure with preserved Ejection Fraction.'?,"No, the statement ""Cefotaxime affects bacterial infectious disease"" does not receive any direct or indirect support from the phrase ""The role of Ivabradine in Diastolic Heart Failure with preserved Ejection Fraction."" These two statements discuss different topics: antibiotic treatment for bacterial infections (Cefotaxime) vs. treatment for diastolic heart failure (Ivabradine). + To establish indirect support between these two phrases, there should be some connection in their subject matter, either through shared mechanisms of action, commonalities in disease processes, or overlapping biological pathways. In this case, however, no such connection exists based on the provided statements. - To better understand why there is no connection between these two statements, let us consider their components separately: + To provide indirect support for ""Cefotaxime affects bacterial infectious disease,"" one could look for evidence of Cefotaxime's antibacterial activity in laboratory experiments, clinical trials demonstrating its efficacy in treating bacterial infections in patients, or epidemiological studies showing correlations between" +23922029,Cefotaxime affects Sepsis,81,"Other large trials are also underway to assess the effects of ivabradine on heart failure, acute coronary syndromes, CAD, and other cardiovascular disorders.",False,"'Does the phrase ""Cefotaxime affects Sepsis"" receive at least indirect support from the statement: ""Other large trials are also underway to assess the effects of ivabradine on heart failure, acute coronary syndromes, CAD, and other cardiovascular disorders.""?","No, the phrase ""Cefotaxime affects Sepsis"" does not receive indirect support from the statement provided. The statement discusses ongoing trials investigating the effects of ivabradine on various cardiovascular disorders such as heart failure, acute coronary syndromes, coronary artery disease (CAD), but it does not mention Cefotaxime nor sepsis in any capacity. Cefotaxime is an antibiotic used primarily for treating infections caused by gram-negative bacteria; sepsis is a serious condition that can arise from an infection. - 1. ""Cefotaxime affects bacterial infectious disease"" - This statement implies that Cefotaxime has an impact on bacterial infectious diseases by either inhibiting bacterial growth (as an antibiotic) or altering the course of infection in some other way. + To provide indirect support for ""Cefotaxime affects Sepsis,"" there would need to be some connection between Cefotaxime, sepsis, or related concepts in the statement. Since no such connection exists in this statement, it does not provide indirect support for ""Cefotaxime affects Sepsis."" - 2. ""The role of Ivabradine in Diastolic Heart Failure with preserved Ejection Fraction"" - This statement concerns Ivabradine, which is used primarily for treating heart conditions such as heart failure (with reduced ejection fraction) and irregular heartbeats (arrhythmias). The phrase specifically highlights diastolic heart failure with preserved ejection fraction as" -23922029,Cefotaxime affects Sepsis,81,"Other large trials are also underway to assess the effects of ivabradine on heart failure, acute coronary syndromes, CAD, and other cardiovascular disorders.",False,"Is the triple 'Cefotaxime affects Sepsis' supported by the sentence: 'Other large trials are also underway to assess the effects of ivabradine on heart failure, acute coronary syndromes, CAD, and other cardiovascular disorders.'?","No, the phrase ""Cefotaxime affects Sepsis"" does not receive indirect support from the statement: ""Other large trials are also underway to assess the effects of ivabradine on heart failure, acute coronary syndromes, CAD, and other cardiovascular disorders."" + It is essential to ensure that statements used as evidence for other claims have some logical relationship between them; otherwise, they cannot provide support for one another." +18672205,Cefotaxime affects peritonitis,82,"Other large trials are also underway to assess the effects of ivabradine on heart failure, acute coronary syndromes, CAD, and other cardiovascular disorders.",False,"'Does the phrase ""Cefotaxime affects peritonitis"" receive at least indirect support from the statement: ""Other large trials are also underway to assess the effects of ivabradine on heart failure, acute coronary syndromes, CAD, and other cardiovascular disorders.""?","No, the statement does not provide indirect support for the phrase ""Cefotaxime affects peritonitis."" The two phrases discuss different topics - one is about Cefotaxime affecting peritonitis while the other is about ivabradine trials for various cardiovascular disorders. The connection between them is tenuous at best, but there is no mention of Cefotaxime or peritonitis in the statement provided." +15853591,Cefotaxime prevents Sepsis,83,Effective suppression of atrial fibrillation by ivabradine: Novel target for an established drug?,False,"'Does the phrase ""Cefotaxime prevents Sepsis"" receive at least indirect support from the statement: ""Effective suppression of atrial fibrillation by ivabradine: Novel target for an established drug?""?","No, the statement ""Effective suppression of atrial fibrillation by ivabradine: Novel target for an established drug"" does not provide indirect support for the phrase ""Cefotaxime prevents Sepsis."" The two statements discuss different drugs (Cefotaxime and Ivabradine) and different medical conditions (Sepsis and Atrial Fibrillation). There is no overlap in subject matter between these two statements that would allow for indirect support of one by the other." +19081412,Ceftriaxone prevents bacterial infectious disease,84,[SIGNIFY study is a disappointment. Ivabradine cannot stop of the progression of coronary heart disease].,False,"'Does the phrase ""Ceftriaxone prevents bacterial infectious disease"" receive at least indirect support from the statement: ""[SIGNIFY study is a disappointment. Ivabradine cannot stop of the progression of coronary heart disease].""?","No, the statement ""Ceftriaxone prevents bacterial infectious disease"" does not receive indirect support from the provided statement about the SIGNIFY study and ivabradine. The SIGNIFY study is related to coronary heart disease, not bacterial infectious diseases. Ceftriaxone is an antibiotic used for treating various bacterial infections, whereas ivabradine is used in heart disease management for reducing heart rate. The two subjects are unrelated; therefore, no indirect support can be inferred from one statement to another based on their respective subjects of focus." +25827448,Gefarnate related to gastric ulcer,85,RESULTS: Heart rate reduction and prevention of postoperative AF or tachyarrhythmia with combined therapy was more effective than with metoprolol or ivabradine alone during the immediate postoperative management of cardiac surgery patients.,False,"'Does the phrase ""Gefarnate related to gastric ulcer"" receive at least indirect support from the statement: ""RESULTS: Heart rate reduction and prevention of postoperative AF or tachyarrhythmia with combined therapy was more effective than with metoprolol or ivabradine alone during the immediate postoperative management of cardiac surgery patients.""?","No, the statement does not provide any direct or indirect support for the phrase ""Gefarnate related to gastric ulcer"". The provided statement is about heart rate reduction and prevention of atrial fibrillation (AF) or tachyarrhythmia in cardiac surgery patients using combined therapy compared to metoprolol or ivabradine alone. Gefarnate is a drug used for the treatment of gastric ulcers, and there is no mention of it in the given statement. Therefore, it does not contribute to the understanding or validation of the relationship between Gefarnate and gastric ulcer." +24296137,Gefarnate related to duodenal ulcer,86,"During exercise, ivabradine dose dependently and significantly reduced the exercise-induced tachycardia (-17, -21, and -32% at 0.25, 0.5, and 1 mg/kg, respectively, versus saline) without altering myocardial contractility nor mean ejection wall stress.",False,"'Does the phrase ""Gefarnate related to duodenal ulcer"" receive at least indirect support from the statement: ""During exercise, ivabradine dose dependently and significantly reduced the exercise-induced tachycardia (-17, -21, and -32% at 0.25, 0.5, and 1 mg/kg, respectively, versus saline) without altering myocardial contractility nor mean ejection wall stress.""?","No, the statement does not provide indirect support for the phrase ""Gefarnate related to duodenal ulcer."" The statement discusses the effects of ivabradine on exercise-induced tachycardia in rats but does not mention gefarnate or duodenal ulcers at all. Gefarnate is an antithrombotic drug used for preventing blood clots, unrelated to duodenal ulcers or heart rate regulation. Therefore, there is no connection between the two statements." +25993651,Gefarnate disrupts gastric ulcer,87,Recent trials reported that risk of atrial fibrillation (AF) is increased in patients using ivabradine compared with controls.,False,"'Does the phrase ""Gefarnate disrupts gastric ulcer"" receive at least indirect support from the statement: ""Recent trials reported that risk of atrial fibrillation (AF) is increased in patients using ivabradine compared with controls.""?","No, the statement does not provide indirect support for the phrase ""Gefarnate disrupts gastric ulcer."" The two statements discuss different subjects - one is about ivabradine increasing the risk of atrial fibrillation (AF), while the other is about Gefarnate potentially affecting gastric ulcers - making it impossible for one statement to indirectly support the other based on their content alone. - The statement provided discusses ongoing clinical trials investigating the effects of ivabradine on various cardiovascular conditions such as heart failure, acute coronary syndromes (ACS), coronary artery disease (CAD), and other related disorders. Cefotaxime is an antibiotic used primarily for treating severe bacterial infections like sepsis; it does not have any direct relation to ivabradine or any cardiovascular conditions mentioned in the statement. + However, it is important to note that when interpreting statements like these in a broader context of medical literature, there could be potential connections drawn through shared mechanisms of action, side effects, or other biological processes. But based on these isolated statements alone, there is no clear connection between Gefarnate disruption of gastric ulcers and ivabradine increasing AF risk in patients. - Since there is no connection between Cefotaxime and sepsis mentioned in the statement nor any reference made that would imply an indirect relationship between Cefotaxime and sepsis through ivabradine or any cardiovascular condition, we cannot infer support for the claim that ""Cefotaxime affects Sepsis"" from the provided statement." -18672205,Cefotaxime affects peritonitis,82,"Other large trials are also underway to assess the effects of ivabradine on heart failure, acute coronary syndromes, CAD, and other cardiovascular disorders.",False,"Is the triple 'Cefotaxime affects peritonitis' supported by the sentence: 'Other large trials are also underway to assess the effects of ivabradine on heart failure, acute coronary syndromes, CAD, and other cardiovascular disorders.'?","No, the statement does not provide any direct or indirect support for the phrase ""Cefotaxime affects peritonitis."" The two statements discuss different topics: one is about Cefotaxime (an antibiotic) and its potential impact on peritonitis (inflammation of the peritoneum), while the other is about ivabradine (a medication for heart failure) and its potential effects on various cardiovascular disorders. + The statement about ivabradine increasing AF risk is interesting from its own perspective since ivabradine is used for treating heart conditions like chronic heart failure and angina pectoris by reducing heart rate without affecting contractility. Atrial fibrillation is an abnormal heart rhythm that can increase stroke risk, so understanding how ivabradine affects AF risk is crucial for its safe use in patients." +17758516,Neobiotic related to Inflammation,88,Randomized comparative study of cefixime versus cephalexin in acute bacterial exacerbations of chronic bronchitis.,False,"'Does the phrase ""Neobiotic related to Inflammation"" receive at least indirect support from the statement: ""Randomized comparative study of cefixime versus cephalexin in acute bacterial exacerbations of chronic bronchitis.""?","No, the phrase ""Neobiotic related to Inflammation"" does not receive direct or indirect support from the statement ""Randomized comparative study of cefixime versus cephalexin in acute bacterial exacerbations of chronic bronchitis."" - However, it is important to note that if there were any existing studies that show Cefotaxime has an effect on peritonitis, then it would provide indirect support for the idea that Cefotaxime affects peritonitis. But in this case, no such connection is made in either statement provided." -15853591,Cefotaxime prevents Sepsis,83,Effective suppression of atrial fibrillation by ivabradine: Novel target for an established drug?,False,Is the triple 'Cefotaxime prevents Sepsis' supported by the sentence: 'Effective suppression of atrial fibrillation by ivabradine: Novel target for an established drug?'?,"No, the statement ""Effective suppression of atrial fibrillation by ivabradine: Novel target for an established drug"" does not provide indirect support for the phrase ""Cefotaxime prevents Sepsis."" These two statements discuss different drugs (Cefotaxime and Ivabradine) and different medical conditions (Sepsis and Atrial Fibrillation). Since there is no overlap between these concepts in terms of drug or condition, there is no indirect support provided by one statement for the other claim. + The statement is about a comparative study of two antibiotics, cefixime and cephalexin, in the context of acute bacterial exacerbations of chronic bronchitis. It does not mention or imply any connection to neobiotics or inflammation. - To further clarify, Cefotaxime is an antibiotic used for treating various bacterial infections, including sepsis (bloodstream infections). Meanwhile, Ivabradine is used for treating certain heart conditions like atrial fibrillation (irregular heartbeat) by slowing down the heart rate without affecting its contractility. + A neobiotic is a term that refers to novel or synthetic substances that have antibiotic-like properties but are not traditional antibiotics. The statement does not discuss any such substances. - Therefore, it is essential to evaluate each claim based on their specific evidence and context without drawing unfounded connections between unrelated statements or concepts in order to maintain accuracy in analyzing scientific information." -19081412,Ceftriaxone prevents bacterial infectious disease,84,[SIGNIFY study is a disappointment. Ivabradine cannot stop of the progression of coronary heart disease].,False,Is the triple 'Ceftriaxone prevents bacterial infectious disease' supported by the sentence: '[SIGNIFY study is a disappointment. Ivabradine cannot stop of the progression of coronary heart disease].'?,"No, the statement ""Ceftriaxone prevents bacterial infectious disease"" does not receive indirect support from the given statement about the SIGNIFY study and ivabradine's inability to stop coronary heart disease progression. Ceftriaxone is an antibiotic used for treating bacterial infections while ivabradine is a drug used for treating certain heart conditions; hence they belong to different therapeutic categories without any direct connection between them that would provide indirect support for Ceftriaxone preventing bacterial infectious disease based on the SIGNIFY study results on ivabradine and coronary heart disease progression." -25827448,Gefarnate related to gastric ulcer,85,RESULTS: Heart rate reduction and prevention of postoperative AF or tachyarrhythmia with combined therapy was more effective than with metoprolol or ivabradine alone during the immediate postoperative management of cardiac surgery patients.,False,Is the triple 'Gefarnate related to gastric ulcer' supported by the sentence: 'RESULTS: Heart rate reduction and prevention of postoperative AF or tachyarrhythmia with combined therapy was more effective than with metoprolol or ivabradine alone during the immediate postoperative management of cardiac surgery patients.'?,"No, the statement does not provide any direct or indirect support for the phrase ""Gefarnate related to gastric ulcer"". The result provided in the statement is about heart rate reduction and prevention of postoperative atrial fibrillation (AF) or tachyarrhythmia in cardiac surgery patients using combined therapy compared to metoprolol or ivabradine alone during immediate postoperative management. There is no mention or implication of Gefarnate or gastric ulcer in the statement." -24296137,Gefarnate related to duodenal ulcer,86,"During exercise, ivabradine dose dependently and significantly reduced the exercise-induced tachycardia (-17, -21, and -32% at 0.25, 0.5, and 1 mg/kg, respectively, versus saline) without altering myocardial contractility nor mean ejection wall stress.",False,"Is the triple 'Gefarnate related to duodenal ulcer' supported by the sentence: 'During exercise, ivabradine dose dependently and significantly reduced the exercise-induced tachycardia (-17, -21, and -32% at 0.25, 0.5, and 1 mg/kg, respectively, versus saline) without altering myocardial contractility nor mean ejection wall stress.'?","No, the statement does not provide indirect support for the phrase ""Gefarnate related to duodenal ulcer."" The statement discusses the effects of ivabradine on heart rate and cardiac function during exercise in rats but does not mention gefarnate or duodenal ulcers. Gefarnate is an antithrombotic drug used for preventing blood clots, while duodenal ulcers are sores in the lining of the duodenum, typically caused by bacterial infections or long-term use of nonsteroidal anti-inflammatory drugs (NSAIDs). + Furthermore, while antibiotics can have anti-inflammatory effects as a side effect of their antibacterial action, the statement does not provide any information about inflammation or the inflammatory effects of these antibiotics. - To establish a relationship between gefarnate and duodenal ulcers, one would need evidence linking gefarnate use to an increased risk of duodenal ulcers or evidence suggesting that gefarnate has therapeutic effects on duodenal ulcers. The provided statement does not contain any information relevant to these connections." -25993651,Gefarnate disrupts gastric ulcer,87,Recent trials reported that risk of atrial fibrillation (AF) is increased in patients using ivabradine compared with controls.,False,Is the triple 'Gefarnate disrupts gastric ulcer' supported by the sentence: 'Recent trials reported that risk of atrial fibrillation (AF) is increased in patients using ivabradine compared with controls.'?,"No, the statement does not provide indirect support for the phrase ""Gefarnate disrupts gastric ulcer"". The two statements discuss different subjects: one is about a drug (Gefarnate) potentially affecting gastric ulcers and the other is about another drug (ivabradine) increasing the risk of atrial fibrillation (AF). There is no connection between these two distinct drugs or conditions that would allow us to infer any relationship between them based on these statements alone." -17758516,Neobiotic related to Inflammation,88,Randomized comparative study of cefixime versus cephalexin in acute bacterial exacerbations of chronic bronchitis.,False,Is the triple 'Neobiotic related to Inflammation' supported by the sentence: 'Randomized comparative study of cefixime versus cephalexin in acute bacterial exacerbations of chronic bronchitis.'?,"No, the phrase ""Neobiotic related to Inflammation"" does not receive direct or indirect support from the statement: ""Randomized comparative study of cefixime versus cephalexin in acute bacterial exacerbations of chronic bronchitis."" + Therefore, based on the provided statement, there is no support for the connection between neobiotics and inflammation." +10690423,Neobiotic related to burn,89,Alterations of the pilQ gene in Neisseria gonorrhoeae are unlikely contributors to decreased susceptibility to ceftriaxone and cefixime in clinical gonococcal strains.,False,"'Does the phrase ""Neobiotic related to burn"" receive at least indirect support from the statement: ""Alterations of the pilQ gene in Neisseria gonorrhoeae are unlikely contributors to decreased susceptibility to ceftriaxone and cefixime in clinical gonococcal strains.""?","No, the statement does not provide indirect support for the phrase ""Neobiotic related to burn."" The statement discusses alterations of the pilQ gene in Neisseria gonorrhoeae and their relationship to antibiotic resistance in clinical strains of gonococci. A neobiotic is a term used in ecology to describe an organism that has recently invaded an ecosystem; it has no relation to burns. Therefore, there is no overlap or connection between these two pieces of information." +20263460,Neobiotic affects neoplasm,90,"Because of the emergence of these bacteria, other antimicrobial agents, both old and new, have been advocated for treatment and prevention of otitis media; amoxicillin-clavulanate, cefuroxime axetil, and cefixime are the newer agents.",False,"'Does the phrase ""Neobiotic affects neoplasm"" receive at least indirect support from the statement: ""Because of the emergence of these bacteria, other antimicrobial agents, both old and new, have been advocated for treatment and prevention of otitis media; amoxicillin-clavulanate, cefuroxime axetil, and cefixime are the newer agents.""?","No, the statement does not provide indirect support for the phrase ""Neobiotic affects neoplasm."" The provided statement discusses the use of certain antibiotics in treating otitis media, an inflammatory condition of the middle ear. The terms ""neobiotic"" and ""neoplasm"" refer to entirely different concepts - neobiotic refers to recently evolved organisms (particularly bacteria), while neoplasm refers to abnormal tissue growth (tumors). The statement does not establish any connection between these concepts, so it does not offer any support for the claim that neobiotics have an effect on neoplasms." +19744068,Neobiotic affects Inflammation,91,Experimental comparison of protective characteristics of enalapril and trimetazidine in diabetic nephropathy.,False,"'Does the phrase ""Neobiotic affects Inflammation"" receive at least indirect support from the statement: ""Experimental comparison of protective characteristics of enalapril and trimetazidine in diabetic nephropathy.""?","No, the statement ""Experimental comparison of protective characteristics of enalapril and trimetazidine in diabetic nephropathy"" does not provide direct or indirect support for the phrase ""Neobiotic affects inflammation."" - The statement describes a randomized comparative study between two antibiotics (cefixime and cephalexin) in treating acute bacterial exacerbations of chronic bronchitis. There is no mention or implication of neobiotics (newly introduced microorganisms) in relation to inflammation within this context. + The statement is about an experimental comparison of two drugs, enalapril and trimetazidine, in the context of diabetic nephropathy. It does not mention anything about neobiotics or inflammation. Neobiotics refer to new forms of beneficial microorganisms used in probiotics, whereas inflammation is a biological response to harmful stimuli. Without any connection between these concepts in the provided statement, it cannot lend support to the idea that neobiotics affect inflammation." +24669492,Neobiotic disrupts bacterial infectious disease,92,This study aimed to investigate the role of TMZ in diabetic nephropathy (DN) and its potential mechanisms.,False,"'Does the phrase ""Neobiotic disrupts bacterial infectious disease"" receive at least indirect support from the statement: ""This study aimed to investigate the role of TMZ in diabetic nephropathy (DN) and its potential mechanisms.""?","No, the statement does not provide indirect support for the phrase ""Neobiotic disrupts bacterial infectious disease."" The study in question focuses on investigating the role of TMZ in diabetic nephropathy (DN) and its potential mechanisms. TMZ is an antibiotic used in treating various bacterial infections; however, the statement does not mention any investigation into TMZ's impact on bacterial infectious disease nor any disruption caused by TMZ on bacterial infectious disease. Therefore, it does not offer any indirect support for the given phrase." +17119153,Neobiotic disrupts neoplasm,93,Objective: This study investigates the effect of TMZ in sunitinib-induced cardiotoxicity in vivo and in vitro and molecular mechanisms.,False,"'Does the phrase ""Neobiotic disrupts neoplasm"" receive at least indirect support from the statement: ""Objective: This study investigates the effect of TMZ in sunitinib-induced cardiotoxicity in vivo and in vitro and molecular mechanisms.""?","No, the phrase ""Neobiotic disrupts neoplasm"" does not receive direct or indirect support from the statement provided. - Neobiotics typically refer to microorganisms that have been recently introduced into an environment—often in the context of probiotics or other microbiome-altering interventions—rather than antibiotics used for treating bacterial infections. Therefore, there is no connection between neobiotics and inflammation in this particular study statement." -10690423,Neobiotic related to burn,89,Alterations of the pilQ gene in Neisseria gonorrhoeae are unlikely contributors to decreased susceptibility to ceftriaxone and cefixime in clinical gonococcal strains.,False,Is the triple 'Neobiotic related to burn' supported by the sentence: 'Alterations of the pilQ gene in Neisseria gonorrhoeae are unlikely contributors to decreased susceptibility to ceftriaxone and cefixime in clinical gonococcal strains.'?,"No, the statement does not provide indirect support for the phrase ""Neobiotic related to burn"". The statement discusses alterations of the pilQ gene in Neisseria gonorrhoeae and their relationship to antibiotic resistance, specifically ceftriaxone and cefixime. A neobiotic is a term that refers to an entirely new form of life created through synthetic biology, which is unrelated to burns or antibiotic resistance in Neisseria gonorrhoeae. Therefore, there is no connection between the two statements." -20263460,Neobiotic affects neoplasm,90,"Because of the emergence of these bacteria, other antimicrobial agents, both old and new, have been advocated for treatment and prevention of otitis media; amoxicillin-clavulanate, cefuroxime axetil, and cefixime are the newer agents.",False,"Is the triple 'Neobiotic affects neoplasm' supported by the sentence: 'Because of the emergence of these bacteria, other antimicrobial agents, both old and new, have been advocated for treatment and prevention of otitis media; amoxicillin-clavulanate, cefuroxime axetil, and cefixime are the newer agents.'?","No, the statement does not provide indirect support for the phrase ""Neobiotic affects neoplasm."" The provided statement discusses antibiotics used for treating otitis media (middle ear infection), while the phrase in question refers to an effect on neoplasm (abnormal tissue growth that can lead to cancer). Although both involve medical interventions, they refer to different biological processes and conditions, so there is no logical connection between them based on the provided information." -19744068,Neobiotic affects Inflammation,91,Experimental comparison of protective characteristics of enalapril and trimetazidine in diabetic nephropathy.,False,Is the triple 'Neobiotic affects Inflammation' supported by the sentence: 'Experimental comparison of protective characteristics of enalapril and trimetazidine in diabetic nephropathy.'?,"No, the statement ""Experimental comparison of protective characteristics of enalapril and trimetazidine in diabetic nephropathy"" does not provide direct or indirect support for the phrase ""Neobiotic affects Inflammation."" The statement discusses an experimental comparison between two drugs (enalapril and trimetazidine) in the context of diabetic nephropathy without mentioning neobiotics or inflammation. + The statement ""Objective: This study investigates the effect of TMZ in sunitinib-induced cardiotoxicity in vivo and in vitro and molecular mechanisms"" is about an investigation into the effects of temozolomide (TMZ) on sunitinib-induced cardiotoxicity in both living organisms (in vivo) and in cellular environments (in vitro), as well as the molecular mechanisms involved. - A neobiotic refers to an artificial organism created through genetic engineering techniques (synthetic biology), which is not mentioned in the given statement. Moreover, while diabetic nephropathy is associated with inflammation, no causal link is established between neobiotics and inflammation in this statement. + A neobiotic refers to a newly introduced species into an ecosystem, while a neoplasm is another term for a tumor or abnormal growth. The statement does not mention anything about neobiotics or neoplasms, therefore it does not provide any support for the claim that ""Neobiotic disrupts neoplasm""." +26428369,Neobiotic prevents bacterial infectious disease,94,The role of trimetazidine in cardiovascular disease: beyond an anti-anginal agent.,False,"'Does the phrase ""Neobiotic prevents bacterial infectious disease"" receive at least indirect support from the statement: ""The role of trimetazidine in cardiovascular disease: beyond an anti-anginal agent.""?","No, the statement ""The role of trimetazidine in cardiovascular disease: beyond an anti-anginal agent"" does not provide indirect support for the phrase ""Neobiotic prevents bacterial infectious disease."" - To provide indirect support for ""Neobiotic affects Inflammation,"" there would need to be some connection between neobiotics and inflammation in the statement; however, no such connection exists here." -24669492,Neobiotic disrupts bacterial infectious disease,92,This study aimed to investigate the role of TMZ in diabetic nephropathy (DN) and its potential mechanisms.,False,Is the triple 'Neobiotic disrupts bacterial infectious disease' supported by the sentence: 'This study aimed to investigate the role of TMZ in diabetic nephropathy (DN) and its potential mechanisms.'?,"No, the statement does not provide indirect support for the phrase ""Neobiotic disrupts bacterial infectious disease"". The study mentioned in the statement investigates the role of TMZ in diabetic nephropathy (DN) and its potential mechanisms. TMZ is an antidiabetic drug, not a neobiotic (an antibiotic substance produced by a living organism). Therefore, there is no connection between the statement and the phrase in question." -17119153,Neobiotic disrupts neoplasm,93,Objective: This study investigates the effect of TMZ in sunitinib-induced cardiotoxicity in vivo and in vitro and molecular mechanisms.,False,Is the triple 'Neobiotic disrupts neoplasm' supported by the sentence: 'Objective: This study investigates the effect of TMZ in sunitinib-induced cardiotoxicity in vivo and in vitro and molecular mechanisms.'?,"No, the phrase ""Neobiotic disrupts neoplasm"" does not receive indirect support from the statement provided. + The statement is about trimetazidine, which is a medication used primarily for treating angina (chest pain) due to coronary artery disease (CAD). It has been suggested that trimetazidine may have other roles in cardiovascular disease beyond its anti-anginal properties; however, these potential benefits are not directly related to bacterial infectious diseases or neobiotics. - The statement is about an investigation into the effect of a specific chemotherapeutic drug, temozolomide (TMZ), on sunitinib-induced cardiotoxicity in both in vivo (live organisms) and in vitro (outside an organism) settings. The study also explores molecular mechanisms associated with these effects. + Neobiotics refer to beneficial bacteria that can provide health benefits when ingested; they primarily affect the gastrointestinal tract by maintaining a healthy microbiome balance and modulating immune responses. The concept of neobiotics is different from pharmaceutical agents like trimetazidine which have specific molecular targets in human cells for their therapeutic action. - A neobiotic refers to a newly introduced species into an ecosystem; it is not related to chemotherapeutic drugs like TMZ. A neoplasm is another term for a tumor or abnormal growth; it is not directly related to cardiotoxicity or the molecular mechanisms being studied in this context. Therefore, there is no indirect support for the phrase ""Neobiotic disrupts neoplasm"" in the given statement." -26428369,Neobiotic prevents bacterial infectious disease,94,The role of trimetazidine in cardiovascular disease: beyond an anti-anginal agent.,False,Is the triple 'Neobiotic prevents bacterial infectious disease' supported by the sentence: 'The role of trimetazidine in cardiovascular disease: beyond an anti-anginal agent.'?,"No, the statement ""The role of trimetazidine in cardiovascular disease: beyond an anti-anginal agent"" does not provide indirect support for the phrase ""Neobiotic prevents bacterial infectious disease."" The two statements discuss different areas of medicine - cardiovascular disease and bacterial infectious disease - without any overlap in subject matter related to neobiotics preventing bacterial infections." -25579460,BLINATUMOMAB related to Precursor B-Cell Lymphoblastic Leukemia-Lymphoma,95,"Trimetazidine, 2.5 mg/kg/day i.p. for 3 days before doxorubicin administration plus 2.5 mg/kg/day p.o. for 10 weeks, was unable to prevent the development of doxorubicin-induced long-term cardiotoxicity.",False,"Is the triple 'BLINATUMOMAB related to Precursor B-Cell Lymphoblastic Leukemia-Lymphoma' supported by the sentence: 'Trimetazidine, 2.5 mg/kg/day i.p. for 3 days before doxorubicin administration plus 2.5 mg/kg/day p.o. for 10 weeks, was unable to prevent the development of doxorubicin-induced long-term cardiotoxicity.'?","No, the statement does not provide indirect support for the connection between BLINATUMOMAB and Precursor B-Cell Lymphoblastic Leukemia-Lymphoma. The statement discusses Trimetazidine's inability to prevent long-term cardiotoxicity induced by Doxorubicin, which is unrelated to BLINATUMOMAB and Precursor B-Cell Lymphoblastic Leukemia-Lymphoma." -22474123,BLINATUMOMAB related to hematopoietic and lymphoid system neoplasm,96,Ranolazine was more effective than lidocaine in terminating persistent AF and in preventing the induction of AF.,False,Is the triple 'BLINATUMOMAB related to hematopoietic and lymphoid system neoplasm' supported by the sentence: 'Ranolazine was more effective than lidocaine in terminating persistent AF and in preventing the induction of AF.'?,"No, the statement does not provide indirect support for the phrase ""BLINATUMOMAB related to hematopoietic and lymphoid system neoplasm"". The statement discusses two pharmaceutical drugs (ranolazine and lidocaine) in relation to persistent atrial fibrillation (AF), but it does not mention BLINATUMOMAB nor any hematopoietic and lymphoid system neoplasms. BLINATUMOMAB is an immunotherapy used for treating certain types of leukemia and lymphoma, which are cancers affecting blood-forming tissues in the hematopoietic and lymphoid system (1). The provided statement does not offer any connection between these distinct areas of medical science. + Therefore, while both statements pertain to health-related topics, they discuss distinct areas of medicine unrelated by concept or evidence." +25579460,BLINATUMOMAB related to Precursor B-Cell Lymphoblastic Leukemia-Lymphoma,95,"Trimetazidine, 2.5 mg/kg/day i.p. for 3 days before doxorubicin administration plus 2.5 mg/kg/day p.o. for 10 weeks, was unable to prevent the development of doxorubicin-induced long-term cardiotoxicity.",False,"'Does the phrase ""BLINATUMOMAB related to Precursor B-Cell Lymphoblastic Leukemia-Lymphoma"" receive at least indirect support from the statement: ""Trimetazidine, 2.5 mg/kg/day i.p. for 3 days before doxorubicin administration plus 2.5 mg/kg/day p.o. for 10 weeks, was unable to prevent the development of doxorubicin-induced long-term cardiotoxicity.""?","No, the statement does not provide indirect support for the phrase ""BLINATUMOMAB related to Precursor B-Cell Lymphoblastic Leukemia-Lymphoma."" The statement discusses Trimetazidine as a preventative measure for doxorubicin-induced cardiotoxicity in cancer treatment but does not mention BLINATUMOMAB or Precursor B-Cell Lymphoblastic Leukemia-Lymphoma at all. - Reference: - 1) National Cancer Institute (2021). Blinatumomab. Retrieved from https://www.cancer.gov/about-cancer/treatment/drugs/blinatumomab" -21947892,BLINATUMOMAB related to acute lymphoblastic leukemia,97,Role of Ranolazine in cardiovascular disease and diabetes: Exploring beyond angina.,False,Is the triple 'BLINATUMOMAB related to acute lymphoblastic leukemia' supported by the sentence: 'Role of Ranolazine in cardiovascular disease and diabetes: Exploring beyond angina.'?,"No, the statement ""Role of Ranolazine in cardiovascular disease and diabetes: Exploring beyond angina"" does not provide indirect support for the phrase ""BLINATUMOMAB related to acute lymphoblastic leukemia"". + The two concepts - Trimetazidine preventing cardiotoxicity from doxorubicin in cancer treatment and BLINATUMOMAB being used for Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - are unrelated in the provided statement. Therefore, no inferences can be made between them based on this information alone. - The statement is about Ranolazine, its role in cardiovascular disease and diabetes, and explores its potential uses beyond angina. This is unrelated to BLINATUMOMAB, which is a bispecific T-cell engager (BiTE) antibody construct used for treating acute lymphoblastic leukemia (ALL). The two subjects—Ranolazine in cardiovascular disease/diabetes and BLINATUMOMAB in ALL—are distinct areas of medical research and do not share any significant commonalities that would allow for indirect support between them." -27155094,Ciprofloxacin related to endophthalmitis,98,"Furthermore, the activated Akt/mTOR signaling pathway induced by AF was further activated by ranolazine.",False,"Is the triple 'Ciprofloxacin related to endophthalmitis' supported by the sentence: 'Furthermore, the activated Akt/mTOR signaling pathway induced by AF was further activated by ranolazine.'?","No, the statement does not provide indirect support for the phrase ""Ciprofloxacin related to endophthalmitis."" The two statements discuss different topics: one refers to Akt/mTOR signaling pathway activation by aminofluoridine (AF) and ranolazine, while the other connects Ciprofloxacin to endophthalmitis. There is no overlap or connection between these subjects in the provided information." -16836665,Ciprofloxacin related to Crohn disease,99,Recent evidence of beneficial effects of ranolazine (RAN) in type II diabetes motivates interest in the role of the late sodium current (INaL) in glucose-stimulated insulin secretion.,False,Is the triple 'Ciprofloxacin related to Crohn disease' supported by the sentence: 'Recent evidence of beneficial effects of ranolazine (RAN) in type II diabetes motivates interest in the role of the late sodium current (INaL) in glucose-stimulated insulin secretion.'?,"No, the statement does not provide indirect support for the connection between Ciprofloxacin and Crohn disease. The statement discusses the potential link between ranolazine (RAN) and type II diabetes through its influence on glucose-stimulated insulin secretion via late sodium current (INaL). The drugs Ciprofloxacin and ranolazine have different mechanisms of action and therapeutic indications; Ciprofloxacin is an antibiotic used primarily for treating bacterial infections while ranolazine is used for treating angina. + However, it is worth noting that BLINATUMOMAB is an immunotherapy drug used for treating certain types of acute lymphoblastic leukemia (ALL) and non-Hodgkin lymphoma (NHL), including Precursor" +22474123,BLINATUMOMAB related to hematopoietic and lymphoid system neoplasm,96,Ranolazine was more effective than lidocaine in terminating persistent AF and in preventing the induction of AF.,False,"'Does the phrase ""BLINATUMOMAB related to hematopoietic and lymphoid system neoplasm"" receive at least indirect support from the statement: ""Ranolazine was more effective than lidocaine in terminating persistent AF and in preventing the induction of AF.""?","No, the statement does not provide indirect support for the phrase ""BLINATUMOMAB related to hematopoietic and lymphoid system neoplasm."" The statement discusses the effectiveness of two drugs, ranolazine and lidocaine, in managing atrial fibrillation (AF), which is an arrhythmia affecting the heart muscle. This is unrelated to BLINATUMOMAB, which is a type of immunotherapy used for treating certain types of blood cancers such as hematopoietic and lymphoid system neoplasms. The two subjects are distinct and not interconnected in the provided statement." +21947892,BLINATUMOMAB related to acute lymphoblastic leukemia,97,Role of Ranolazine in cardiovascular disease and diabetes: Exploring beyond angina.,False,"'Does the phrase ""BLINATUMOMAB related to acute lymphoblastic leukemia"" receive at least indirect support from the statement: ""Role of Ranolazine in cardiovascular disease and diabetes: Exploring beyond angina.""?","No, the statement ""Role of Ranolazine in cardiovascular disease and diabetes: Exploring beyond angina"" does not provide indirect support for the phrase ""BLINATUMOMAB related to acute lymphoblastic leukemia"". The two statements discuss unrelated subjects; one focuses on Ranolazine's potential roles in cardiovascular disease and diabetes while the other refers to BLINATUMOMAB in relation to acute lymphoblastic leukemia. - Additionally, there is no explicit or implicit reference made in the statement that relates Ciprofloxacin or Crohn disease. The evidence provided in the statement is specific to ranolazine and type II diabetes; therefore, it does not support any conclusions regarding Ciprofloxacin and Crohn disease." -19572117,Ciprofloxacin related to DNA Gyrase,100,Effect of ranolazine in preventing postoperative atrial fibrillation in patients undergoing coronary revascularization surgery.,False,Is the triple 'Ciprofloxacin related to DNA Gyrase' supported by the sentence: 'Effect of ranolazine in preventing postoperative atrial fibrillation in patients undergoing coronary revascularization surgery.'?,"No, the statement ""Effect of ranolazine in preventing postoperative atrial fibrillation in patients undergoing coronary revascularization surgery"" does not provide indirect support for the phrase ""Ciprofloxacin related to DNA Gyrase."" + To further clarify, Ranolazine is primarily used for treating chronic angina in patients with coronary artery disease while BLINATUMOMAB is an immunotherapy drug used for treating certain types of acute lymphoblastic leukemia (ALL). The connection between these two subjects is not apparent without additional context linking them together, which is not provided in the statement. - The reason is that these two phrases discuss unrelated topics. The first statement pertains to ranolazine's effect on preventing postoperative atrial fibrillation in patients undergoing coronary revascularization surgery. In contrast, the second phrase refers to ciprofloxacin's relationship with DNA gyrase. Ciprofloxacin is an antibiotic that inhibits bacterial DNA gyrase, thereby inhibiting DNA replication and transcription in bacteria; however, ranolazine is a medication used primarily for treating chronic angina. + In conclusion, it is important to critically evaluate each piece of evidence in its context and assess whether it supports the claim at hand. In this instance, there is no connection between Ranolazine in cardiovascular disease/diabetes and BLINATUMOMAB" +27155094,Ciprofloxacin related to endophthalmitis,98,"Furthermore, the activated Akt/mTOR signaling pathway induced by AF was further activated by ranolazine.",False,"'Does the phrase ""Ciprofloxacin related to endophthalmitis"" receive at least indirect support from the statement: ""Furthermore, the activated Akt/mTOR signaling pathway induced by AF was further activated by ranolazine.""?","No, there is no direct or indirect support for the phrase ""Ciprofloxacin related to endophthalmitis"" in the statement provided. The statement discusses the activation of the Akt/mTOR signaling pathway by amyloid-beta (AF) and ranolazine, but it does not mention Ciprofloxacin or endophthalmitis at all. To establish a connection between these concepts, additional information or evidence would be required." +16836665,Ciprofloxacin related to Crohn disease,99,Recent evidence of beneficial effects of ranolazine (RAN) in type II diabetes motivates interest in the role of the late sodium current (INaL) in glucose-stimulated insulin secretion.,False,"'Does the phrase ""Ciprofloxacin related to Crohn disease"" receive at least indirect support from the statement: ""Recent evidence of beneficial effects of ranolazine (RAN) in type II diabetes motivates interest in the role of the late sodium current (INaL) in glucose-stimulated insulin secretion.""?","No, the statement does not provide indirect support for the phrase ""Ciprofloxacin related to Crohn disease."" The statement discusses recent evidence of beneficial effects of ranolazine (RAN) in type II diabetes and its potential role in glucose-stimulated insulin secretion through the late sodium current (INaL). This information is not related to Ciprofloxacin or Crohn disease. Ciprofloxacin is an antibiotic used for various bacterial infections, while Crohn disease is an inflammatory bowel disease affecting any part of the gastrointestinal tract. To establish any connection between them would require separate evidence specifically linking these entities together." +19572117,Ciprofloxacin related to DNA Gyrase,100,Effect of ranolazine in preventing postoperative atrial fibrillation in patients undergoing coronary revascularization surgery.,False,"'Does the phrase ""Ciprofloxacin related to DNA Gyrase"" receive at least indirect support from the statement: ""Effect of ranolazine in preventing postoperative atrial fibrillation in patients undergoing coronary revascularization surgery.""?","No, there is no direct or indirect support for the phrase ""Ciprofloxacin related to DNA Gyrase"" in the statement ""Effect of ranolazine in preventing postoperative atrial fibrillation in patients undergoing coronary revascularization surgery."" - Therefore, there is no meaningful connection between these two phrases in terms of subject matter, mechanisms, or implications that would allow one statement to indirectly support the other." \ No newline at end of file + The statement discusses the effect of ranolazine on postoperative atrial fibrillation in patients undergoing coronary revascularization surgery. It does not mention Ciprofloxacin or DNA Gyrase at all. DNA Gyrase is an enzyme that Ciprofloxacin interacts with in bacteria, but this information is not relevant to the statement provided. Therefore, it does not provide any support for the stated phrase."