From b8eb9e2989fd3de6cbc4b449c023e5869e1e93e8 Mon Sep 17 00:00:00 2001 From: Maksym Date: Tue, 27 Feb 2024 18:29:07 -0500 Subject: [PATCH] LLMFactCheck --- data/1.csv | 1114 +++++++++++++++++++++++++++++++++---- false_labeled_records.csv | 1001 ++++++++++++++++----------------- false_sentence_data.csv | 993 ++++++++++++++++----------------- false_triple_data.csv | 1001 ++++++++++++++++----------------- src/get_result.py | 2 +- util/chembl/convert.py | 16 +- 6 files changed, 2524 insertions(+), 1603 deletions(-) diff --git a/data/1.csv b/data/1.csv index 4b24189..c6b0be0 100644 --- a/data/1.csv +++ b/data/1.csv @@ -1,101 +1,1015 @@ Predicate ID,Triple,Sentence ID,Sentence,Is Correct,Question,Answer -24413653,Fenbendazole treats helminthiasis,1001,"This study investigated worm control practices by free-range egg farmers and the efficacy of the commercial anthelmintics levamisole (LEV), piperazine (PIP), flubendazole (FLBZ) and fenbendazole (FBZ) against gastrointestinal nematodes on two free-range layer farms in Australia.",True,"Is the triple 'Fenbendazole treats helminthiasis' supported by the sentence: 'This study investigated worm control practices by free-range egg farmers and the efficacy of the commercial anthelmintics levamisole (LEV), piperazine (PIP), flubendazole (FLBZ) and fenbendazole (FBZ) against gastrointestinal nematodes on two free-range layer farms in Australia.'?","Yes, the statement ""Fenbendazole treats helminthiasis"" is at least indirectly supported by the provided sentence, as it mentions that a study was conducted to investigate the efficacy of fenbendazole (FBZ) against gastrointestinal nematodes, which is a type of helminthiasis (parasitic worm infection). However, it's important to note that this is an indirect inference, as the provided sentence does not directly state that fenbendazole is effective in treating helminthiasis." -9783282,Thiabendazole treats helminthiasis,1002,[The treatment of helminthiasis with thiabendazole].,True,Is the triple 'Thiabendazole treats helminthiasis' supported by the sentence: '[The treatment of helminthiasis with thiabendazole].'?,"Yes, it is directly supported, as thiabendazole is mentioned as a treatment for helminthiasis in both statements." -22678969,Albendazole treats Infection,1003,The control of STH infections is based on preventive chemotherapy using either albendazole or mebendazole.,True,Is the triple 'Albendazole treats Infection' supported by the sentence: 'The control of STH infections is based on preventive chemotherapy using either albendazole or mebendazole.'?,"Yes, it is indirectly supported because both albendazole and mebendazole are used for preventive chemotherapy to control Soil-transmitted Helminthiasis (STH) infections, implying that albendazole can treat such infections as part of this treatment strategy." -10750815,Albendazole treats onchocerciasis,1004,"A double-blind clinical trial was conducted in Monagas State, Venezuela to assess the tolerance and efficacy of albendazole in the therapy of Onchocerca volvulus infection.",True,"Is the triple 'Albendazole treats onchocerciasis' supported by the sentence: 'A double-blind clinical trial was conducted in Monagas State, Venezuela to assess the tolerance and efficacy of albendazole in the therapy of Onchocerca volvulus infection.'?","Yes, it is indirectly supported because a clinical trial assessing albendazole's efficacy against Onchocerca volvulus infection implies that albendazole is a potential treatment for onchocerciasis, which is caused by this parasite. However, it doesn't directly state that albendazole treats onchocerciasis, but rather that it's being tested for its efficacy against it in a clinical setting." -10114050,Albendazole treats toxocariasis,1005,"The treatment of cutaneous larva migrans and Toxocara infection relies on antihelminthic agents such as thiabendazole, albendazole and ivermectin.",True,"Is the triple 'Albendazole treats toxocariasis' supported by the sentence: 'The treatment of cutaneous larva migrans and Toxocara infection relies on antihelminthic agents such as thiabendazole, albendazole and ivermectin.'?","Yes, it is. The given sentence mentions Albendazole as one of the antihelminthic agents used in treating Toxocara infection, which implies that Albendazole can be used to treat Toxocariasis, a disease caused by Toxocara infection." -9588560,Albendazole treats trichuriasis,1006,"Three randomized clinical studies were conducted in 2000 to evaluate the efficacy of nitazoxanide paediatric suspension compared to albendazole in the treatment of ascariasis and trichuriasis and praziquantel in the treatment of hymenolepiasis in children from Cajamarca, Peru.",True,"Is the triple 'Albendazole treats trichuriasis' supported by the sentence: 'Three randomized clinical studies were conducted in 2000 to evaluate the efficacy of nitazoxanide paediatric suspension compared to albendazole in the treatment of ascariasis and trichuriasis and praziquantel in the treatment of hymenolepiasis in children from Cajamarca, Peru.'?","Yes, it is indirectly supported. The statement mentions that albendazole was used in a study to treat trichuriasis, which aligns with the claim that albendazazole can be used to treat trichuriasis. However, it does not directly state that albendazole treats trichuriasis, but rather that it was used in a study to treat it." -9492446,Albendazole treats filariasis,1007,"Today, the only way is the prophylactic control of Onchocerca vovulus infections and treating lymphatic filariosis with ivermectin, diethylcarbamacine, ivermectin/diethylcarbamazine. or ivermectin/albendazole combinations.",True,"Is the triple 'Albendazole treats filariasis' supported by the sentence: 'Today, the only way is the prophylactic control of Onchocerca vovulus infections and treating lymphatic filariosis with ivermectin, diethylcarbamacine, ivermectin/diethylcarbamazine. or ivermectin/albendazole combinations.'?","Yes, it is indirectly supported. Although the sentence does not explicitly state that Albendazole treats filariasis, it does mention that it can be used in combination with ivermectin to treat lymphatic filariosis, which is a form of filariasis caused by Wuchereria bancrofti, Brugia malayi and Brugia timori nematodes." -8712067,Albendazole treats helminthiasis,1008,The study population was assessed for helminthic infection and those found to be positive were randomly assigned to either an albendazole treatment group or a control group who received a placebo.,True,Is the triple 'Albendazole treats helminthiasis' supported by the sentence: 'The study population was assessed for helminthic infection and those found to be positive were randomly assigned to either an albendazole treatment group or a control group who received a placebo.'?,"Yes, the statement ""Albendazole treats helminthiasis"" is indirectly supported by the provided sentence. This is because the sentence mentions that individuals with helminthic infection were treated with albendazole, implying that albendazole has some effect on treating this condition. However, it's important to note that a single sentence does not provide comprehensive evidence, and a more thorough review of scientific literature would be needed to fully support this claim." -7789677,Albendazole treats strongyloidiasis,1009,"To determine the host factors involved in response to treatment, 46 patients with strongyloidiasis were treated with albendazole, followed-up for 1 year, and separated into two groups: cured and non-cured.",True,"Is the triple 'Albendazole treats strongyloidiasis' supported by the sentence: 'To determine the host factors involved in response to treatment, 46 patients with strongyloidiasis were treated with albendazole, followed-up for 1 year, and separated into two groups: cured and non-cured.'?","Yes, it is. The statement implies that albendazole was used to treat patients with strongyloidiasis, which aligns with the information that albendazole can be used to treat this condition. However, it doesn't directly state that albendazole treats strongyloidiasis, but rather infers it." -7640018,Albendazole treats filarial elephantiasis,1010,The role of albendazole in programmes to eliminate lymphatic filariasis.,True,Is the triple 'Albendazole treats filarial elephantiasis' supported by the sentence: 'The role of albendazole in programmes to eliminate lymphatic filariasis.'?,"Yes, the statement ""Albendazole treats filarial elephantiasis"" is indirectly supported by the given sentence, as it suggests that Albendazole is used in programs aimed at eliminating lymphatic filariasis, a disease commonly known as elephantiasis, which is caused by parasitic worms. Therefore, it can be inferred that Albendazole is used to treat this condition, although it does not explicitly state that it 'treats' the disease, but rather is used in efforts to eliminate it." -7620262,Albendazole treats Hookworm Infections,1011,On the basis of our results the single 400 mg dose of albendazole is the treatment of choice for hookworm infections in this region of Mali.,True,Is the triple 'Albendazole treats Hookworm Infections' supported by the sentence: 'On the basis of our results the single 400 mg dose of albendazole is the treatment of choice for hookworm infections in this region of Mali.'?,"Yes, it is indirectly supported because it suggests that albendazole is an effective treatment for hookworm infections, but it does not explicitly state that it treats hookworm infections in all cases, such as in other regions outside Mali." -7226097,Albendazole treats cysticercosis,1012,The efficacy of albendazole (15 mg/kg/d for 1 week) was compared with praziquantel (100 mg/kg in three divided doses at 2-hour intervals) for therapy of parenchymal brain cysticercosis.,True,Is the triple 'Albendazole treats cysticercosis' supported by the sentence: 'The efficacy of albendazole (15 mg/kg/d for 1 week) was compared with praziquantel (100 mg/kg in three divided doses at 2-hour intervals) for therapy of parenchymal brain cysticercosis.'?,"Yes, it is indirectly supported because it mentions that Albendazole is used in the treatment of parenchymal brain cysticercosis, which is a form of cysticercosis. However, it does not directly state that Albendazole treats cysticercosis, but rather that it is used in a specific form of treatment for it." -25678577,Latamoxef treats bacterial infectious disease,1013,"Clinical efficacy and safety of a new oxacephem, moxalactam, in serious bacterial infections.",True,"Is the triple 'Latamoxef treats bacterial infectious disease' supported by the sentence: 'Clinical efficacy and safety of a new oxacephem, moxalactam, in serious bacterial infections.'?","Yes, it is indirectly supported. The mention of moxalactam, which is an oxacephem, being used for serious bacterial infections suggests that other oxacephems, like latamoxef, could also be used for similar purposes, thus treating bacterial infections. However, it's important to note that this is an inference, not a direct statement, so it's indirect support." -26824955,Ibuprofen treats spondylosis,1014,A comparison of the short-term effects of ibuprofen and diclofenac in spondylosis.,True,Is the triple 'Ibuprofen treats spondylosis' supported by the sentence: 'A comparison of the short-term effects of ibuprofen and diclofenac in spondylosis.'?,"Yes, it is indirectly supported. The given sentence suggests that both Ibuprofen and Diclofenac have been studied in relation to spondylosis, implying that Ibuprofen is a potential treatment for this condition." -25670779,Ibuprofen treats sunburn,1015,"The data suggest that ibuprofen is more effective than placebo for the relief of symptoms associated with UV-B-induced inflammation after high dose UV-B phototherapy for psoriasis, but the drug has limited usefulness in the treatment of sunburn reaction from these same doses.",True,"Is the triple 'Ibuprofen treats sunburn' supported by the sentence: 'The data suggest that ibuprofen is more effective than placebo for the relief of symptoms associated with UV-B-induced inflammation after high dose UV-B phototherapy for psoriasis, but the drug has limited usefulness in the treatment of sunburn reaction from these same doses.'?","Yes, it can be interpreted as indirect support because ibuprofen has been shown to alleviate symptoms associated with UV-B-induced inflammation, which is a component of sunburn. However, it's important to note that the statement also suggests limited usefulness in treating sunburn reactions from high dose UV-B phototherapy, implying it may not be as effective for severe sunburns." -25518118,Ibuprofen treats Fractured ankle,1016,"Huoxue Huayu Recipe combined with ibuprofen can reduce inflammatory factors levels in patients with ankle fracture, improve isokinetic muscle strength and ankle function, and accelerate the recovery of patients.",True,"Is the triple 'Ibuprofen treats Fractured ankle' supported by the sentence: 'Huoxue Huayu Recipe combined with ibuprofen can reduce inflammatory factors levels in patients with ankle fracture, improve isokinetic muscle strength and ankle function, and accelerate the recovery of patients.'?","Yes, it is indirectly supported. The given sentence suggests that ibuprofen, when used in combination with a certain recipe, can help reduce inflammation and improve recovery in patients with ankle fractures. This implies that ibuprofen could potentially have a positive effect on treating a fractured ankle, although it doesn't directly state that ibuprofen alone can treat a fractured ankle." -25321029,Ibuprofen treats bronchopulmonary dysplasia,1017,"Treatment of newborn rat pups with ibuprofen reduced pulmonary vessel density in the developing lung, but also attenuated experimental BPD by reducing lung inflammation, alveolar enlargement, alveolar septum thickness and small arteriolar wall thickening.",True,"Is the triple 'Ibuprofen treats bronchopulmonary dysplasia' supported by the sentence: 'Treatment of newborn rat pups with ibuprofen reduced pulmonary vessel density in the developing lung, but also attenuated experimental BPD by reducing lung inflammation, alveolar enlargement, alveolar septum thickness and small arteriolar wall thickening.'?","Yes, it is indirectly supported because ibuprofen's ability to reduce lung inflammation, alveolar enlargement, alveolar septum thickness, and small arteriolar wall thickening in rat pups suggests a potential therapeutic effect on bronchopulmonary dysplasia (BPD), a disease characterized by these symptoms in human infants. However, this is based on an animal study, so further research is needed to confirm its applicability in humans." -22125431,Ibuprofen treats preeclampsia,1018,Introduction: The comparison of ibuprofen with acetaminophen for blood pressure (BP) in preeclampsia remains controversial.,False,Is the triple 'Ibuprofen treats preeclampsia' supported by the sentence: 'Introduction: The comparison of ibuprofen with acetaminophen for blood pressure (BP) in preeclampsia remains controversial.'?,"No, it is not indirectly supported because the sentence discusses a controversy between ibuprofen and acetaminophen, not specifically addressing whether ibuprofen treats preeclampsia." -21268743,Ibuprofen treats glioma,1019,"Taken together, our findings reveal that ibuprofen could induce ferroptosis of glioblastoma cells via downregulation of Nrf2 signaling pathway and is a potential drug for glioma treatment.",True,"Is the triple 'Ibuprofen treats glioma' supported by the sentence: 'Taken together, our findings reveal that ibuprofen could induce ferroptosis of glioblastoma cells via downregulation of Nrf2 signaling pathway and is a potential drug for glioma treatment.'?","Yes, the statement does provide some support for the idea that Ibuprofen could be used in treating gliomas. It suggests that Ibuprofen can induce ferroptosis in glioblastoma cells (a type of glioma) and that it does this by downregulating the Nrf2 signaling pathway. However, it's important to note that this is based on a specific study's findings and may not be universally applicable. Further research would be needed to confirm these results and explore their implications for treatment." -20821983,Ibuprofen treats common cold,1020,Ibuprofen (IBU) and phenylephrine hydrochloride (PE) were commonly used for common cold due to their different effects in relieving fever and the main symptoms such as nasal congestion and high sinus pressure.,True,Is the triple 'Ibuprofen treats common cold' supported by the sentence: 'Ibuprofen (IBU) and phenylephrine hydrochloride (PE) were commonly used for common cold due to their different effects in relieving fever and the main symptoms such as nasal congestion and high sinus pressure.'?,"Yes, it is indirectly supported because it mentions Ibuprofen being used for treating symptoms of the common cold, but it does not explicitly state that Ibuprofen can cure the common cold itself, which is a broader claim than just treating symptoms." -20285347,Ibuprofen treats periodontitis,1021,"Therefore, the objective of this study was to investigate the local delivery of the NSAIDs model drug ibuprofen to treat periodontitis using different types of gel formulations (hydrogel, oleogel, and bigel).",True,"Is the triple 'Ibuprofen treats periodontitis' supported by the sentence: 'Therefore, the objective of this study was to investigate the local delivery of the NSAIDs model drug ibuprofen to treat periodontitis using different types of gel formulations (hydrogel, oleogel, and bigel).'?","Yes, it is indirectly supported because the statement mentions ibuprofen being used in a study focused on treating periodontitis with different types of gel formulations." -19270581,Ibuprofen treats bone fracture,1022,Does the Use of Ibuprofen in Children with Extremity Fractures Increase their Risk for Bone Healing Complications?,False,Is the triple 'Ibuprofen treats bone fracture' supported by the sentence: 'Does the Use of Ibuprofen in Children with Extremity Fractures Increase their Risk for Bone Healing Complications?'?,"No, it is not directly or indirectly supported, as this statement suggests that ibuprofen may increase risks for complications, rather than aiding in bone healing." -17621968,Ibuprofen treats Cognitive impairment,1023,"Finally, anti-inflammatory drug ibuprofen ameliorated the peripheral surgical wounding-induced cognitive impairment in 18 month-old mice.",True,"Is the triple 'Ibuprofen treats Cognitive impairment' supported by the sentence: 'Finally, anti-inflammatory drug ibuprofen ameliorated the peripheral surgical wounding-induced cognitive impairment in 18 month-old mice.'?","Yes, it is indirectly supported because both statements suggest that ibuprofen has a positive effect on cognitive function in the context of cognitive impairment caused by surgical wounding in mice. However, it's important to note that cognitive impairment is a complex issue in humans that may not be directly comparable to the cognitive effects observed in mice after surgical procedures. Therefore, further research is needed to confirm whether ibuprofen can effectively treat cognitive impairment in humans." -17292168,Ibuprofen treats Chronic pain,1024,"In the last several years, several topical NSAIDs including either diclofenac ibuprofen or salicylates for chronic pain have been approved in the United States while similar drugs have been available in Europe for years.",True,"Is the triple 'Ibuprofen treats Chronic pain' supported by the sentence: 'In the last several years, several topical NSAIDs including either diclofenac ibuprofen or salicylates for chronic pain have been approved in the United States while similar drugs have been available in Europe for years.'?","Yes, it is indirectly supported. The statement mentions that ibuprofen (an NSAID) has been approved for chronic pain in the United States, which suggests that it is effective for this purpose." -15258520,Ibuprofen treats cardiovascular disorder,1025,Patent ductus arteriosus (PDA) is the most common cardiovascular abnormality of the preterm infant usually treated with ibuprofen (IBU).,False,Is the triple 'Ibuprofen treats cardiovascular disorder' supported by the sentence: 'Patent ductus arteriosus (PDA) is the most common cardiovascular abnormality of the preterm infant usually treated with ibuprofen (IBU).'?,"No, this statement does not support that Ibuprofen treats cardiovascular disorders in general, but it does indicate that Ibuprofen is used to treat a specific cardiovascular abnormality, PDA, in preterm infants." -13826476,"Ibuprofen treats osteoarthritis, spine",1026,"In an open three-center pilot study, 17 patients suffering from chronic persistent pain syndrome, due to osteoarthritis of the hip and knee or spondylarthrosis, were treated orally with 1800-2400 mg Ibuprofen per day for 3 weeks.",True,"Is the triple 'Ibuprofen treats osteoarthritis, spine' supported by the sentence: 'In an open three-center pilot study, 17 patients suffering from chronic persistent pain syndrome, due to osteoarthritis of the hip and knee or spondylarthrosis, were treated orally with 1800-2400 mg Ibuprofen per day for 3 weeks.'?","Yes, it is indirectly supported. The given study mentions that patients with chronic persistent pain syndrome due to hip and knee osteoarthritis or spondylarthrosis were treated with Ibuprofen for 3 weeks, which suggests that Ibuprofen may help alleviate pain related to these conditions. However, it does not directly state that Ibuprofen treats these conditions, but rather suggests it may help manage symptoms related to them." -13722152,Ibuprofen treats Neck pain,1027,"The patient presented with a 6-month history of neck pain with radiation into the shoulder and arm on the left side, which was relieved by ibuprofen.",True,"Is the triple 'Ibuprofen treats Neck pain' supported by the sentence: 'The patient presented with a 6-month history of neck pain with radiation into the shoulder and arm on the left side, which was relieved by ibuprofen.'?","Yes, it is indirectly supported. The sentence suggests that ibuprofen was effective in relieving the neck pain, which aligns with the statement that ibuprofen treats neck pain, although it does not explicitly state that ibuprofen is used for treating neck pain in general." -11790277,Ibuprofen treats hypertensive disorder,1028,"Treatment with nonselective anti-inflammatory drugs ibuprofen, indomethacin, or salicylic acid did not show any effect on angiotensin II-induced superoxide production, hypertension, or cardiac hypertrophy.",False,"Is the triple 'Ibuprofen treats hypertensive disorder' supported by the sentence: 'Treatment with nonselective anti-inflammatory drugs ibuprofen, indomethacin, or salicylic acid did not show any effect on angiotensin II-induced superoxide production, hypertension, or cardiac hypertrophy.'?","No, it is not directly or indirectly supported, as this statement suggests that ibuprofen, along with other nonsteroidal anti-inflammatory drugs, does not have an impact on angiotensin II-induced superoxide production, hypertension, or cardiac hypertrophy, which contradicts the idea that ibuprofen can treat hypertensive disorders." -11536369,Ibuprofen treats seasonal allergic rhinitis,1029,Addition of ibuprofen to pseudoephedrine and chlorpheniramine in the treatment of seasonal allergic rhinitis.,True,Is the triple 'Ibuprofen treats seasonal allergic rhinitis' supported by the sentence: 'Addition of ibuprofen to pseudoephedrine and chlorpheniramine in the treatment of seasonal allergic rhinitis.'?,"Yes, it is indirectly supported, as it suggests that Ibuprofen can be used in treating seasonal allergic rhinitis, which aligns with the statement in your question." -11381904,Ibuprofen treats Premature birth,1030,This should be considered to assess pharmacokinetic-pharmacodynamic relationships of ibuprofen in premature neonates and subsequently to understand and refine the use of ibuprofen in managing PDA either as a prophylactic or curative treatment.,True,Is the triple 'Ibuprofen treats Premature birth' supported by the sentence: 'This should be considered to assess pharmacokinetic-pharmacodynamic relationships of ibuprofen in premature neonates and subsequently to understand and refine the use of ibuprofen in managing PDA either as a prophylactic or curative treatment.'?,"Yes, it is indirectly supported. The given sentence discusses the use of ibuprofen in managing PDA (Patent Ductus Arteriosus) in premature neonates, which implies that ibuprofen can be used for premature births, even if it doesn't explicitly state that ibuprofen treats premature birth." -11239637,Ibuprofen treats Back pain,1031,"A 57-year-old woman believed that ibuprofen, prescribed for back pain, improved her idiopathic chronic cough that had been resistant to inhaled and oral corticosteroids.",True,"Is the triple 'Ibuprofen treats Back pain' supported by the sentence: 'A 57-year-old woman believed that ibuprofen, prescribed for back pain, improved her idiopathic chronic cough that had been resistant to inhaled and oral corticosteroids.'?","Yes, it is indirectly supported, as it suggests a positive effect of Ibuprofen on a patient with chronic cough, which might be related to back pain treatment, although not directly stated in this case." -10195210,Ibuprofen treats influenza,1032,"A multicenter, randomized, double-blind, double-dummy, placebo- and active-controlled, parallel-group comparison of diclofenac-K and ibuprofen for the treatment of adults with influenza-like symptoms.",False,"Is the triple 'Ibuprofen treats influenza' supported by the sentence: 'A multicenter, randomized, double-blind, double-dummy, placebo- and active-controlled, parallel-group comparison of diclofenac-K and ibuprofen for the treatment of adults with influenza-like symptoms.'?",No. The provided statement does not directly support that Ibuprofen treats influenza as it is comparing diclofenac-K with ibuprofen for treating adults with symptoms similar to influenza. It does not confirm that ibuprofen can treat influenza itself. -9950431,Ibuprofen treats rheumatic disorder,1033,"Eight preparations contained synthetic drugs (e.g. benzodiazepines and tricyclic antidepressants in sedative preparations, cyproheptadine in a remedy to gain bodyweight, ibuprofen and dipyrone in herbal capsules used to treat rheumatism).",True,"Is the triple 'Ibuprofen treats rheumatic disorder' supported by the sentence: 'Eight preparations contained synthetic drugs (e.g. benzodiazepines and tricyclic antidepressants in sedative preparations, cyproheptadine in a remedy to gain bodyweight, ibuprofen and dipyrone in herbal capsules used to treat rheumatism).'?","Yes, it is indirectly supported because ibuprofen, which is a synthetic drug, is mentioned as being in a herbal capsule used to treat rheumatism." -9913360,Ibuprofen treats Myalgia,1034,Preliminary comparison of bromelain and Ibuprofen for delayed onset muscle soreness management.,True,Is the triple 'Ibuprofen treats Myalgia' supported by the sentence: 'Preliminary comparison of bromelain and Ibuprofen for delayed onset muscle soreness management.'?,"Yes, it is indirectly supported. The sentence suggests that like ibuprofen, bromelain can also be used to manage delayed onset muscle soreness (Myalgia). Therefore, it supports the idea that ibuprofen can be used to treat Myalgia." -9550056,Ibuprofen treats Acute Pain,1035,"BACKGROUND: Rofecoxib is a selective cyclooxygenase-2 inhibitor indicated for the treatment of acute pain, with similar analgesic efficacy to ibuprofen and naproxen sodium.",True,"Is the triple 'Ibuprofen treats Acute Pain' supported by the sentence: 'BACKGROUND: Rofecoxib is a selective cyclooxygenase-2 inhibitor indicated for the treatment of acute pain, with similar analgesic efficacy to ibuprofen and naproxen sodium.'?","Yes, it is indirectly supported. The background information states that Rofecoxib, similar to Ibuprofen, is indicated for the treatment of acute pain, suggesting that Ibuprofen can also treat acute pain." -9536612,Ibuprofen treats Low back pain,1036,CONCLUSION: Continuous low-level heat wrap therapy was superior to both acetaminophen and ibuprofen for treating low back pain.,True,Is the triple 'Ibuprofen treats Low back pain' supported by the sentence: 'CONCLUSION: Continuous low-level heat wrap therapy was superior to both acetaminophen and ibuprofen for treating low back pain.'?,"Yes, it is indirectly supported because it mentions that Ibuprofen is used for treating low back pain, even though it was found to be less effective than continuous low-level heat wrap therapy in this particular study." -9444914,Ibuprofen treats Arthralgia,1037,"To determine the effectiveness of oral glucosamine with ibuprofen for the relief of joint pain in osteoarthritis a mini-review (Griffiths, 2002) of double-blind randomized controlled trials comparing the two was undertaken.",False,"Is the triple 'Ibuprofen treats Arthralgia' supported by the sentence: 'To determine the effectiveness of oral glucosamine with ibuprofen for the relief of joint pain in osteoarthritis a mini-review (Griffiths, 2002) of double-blind randomized controlled trials comparing the two was undertaken.'?","No, it's not directly or indirectly supported. The sentence you provided discusses a review of studies comparing oral glucosamine with ibuprofen for osteoarthritis joint pain relief, but it doesn't mention arthralgia, which is a general term for joint pain, not specifically related to osteoarthritis." -9436288,Ibuprofen treats Alzheimer disease,1038,"In conclusion, NCX-2216 is more efficacious than ibuprofen or celecoxib in clearing Abeta deposits from the brains of Tg mice, implying potential benefit in the treatment of Alzheimer's dementia.",False,"Is the triple 'Ibuprofen treats Alzheimer disease' supported by the sentence: 'In conclusion, NCX-2216 is more efficacious than ibuprofen or celecoxib in clearing Abeta deposits from the brains of Tg mice, implying potential benefit in the treatment of Alzheimer's dementia.'?","No. The statement does not support that Ibuprofen treats Alzheimer's disease directly or indirectly. It compares the efficacy of another compound (NCX-2216) with Ibuprofen in clearing Abeta deposits in mice brains, which is a characteristic of Alzheimer's dementia, but it does not provide evidence that Ibuprofen itself is effective in treating Alzheimer's disease in humans." -9104501,Ibuprofen treats injury,1039,"Ibuprofen attenuates early lung injury in endotoxemic, neutropenic rats.",True,"Is the triple 'Ibuprofen treats injury' supported by the sentence: 'Ibuprofen attenuates early lung injury in endotoxemic, neutropenic rats.'?","Yes, it is indirectly supported, as both statements suggest that Ibuprofen has a positive effect on treating or reducing injury, one specifically related to lung injury in rats, and the other more generally related to any kind of injury. However, it's important to note that direct correlation may not be present without further investigation." -8748381,Ibuprofen treats Dysmenorrhea,1040,CONCLUSION: Continuous low-level topical heat therapy was as effective as ibuprofen for the treatment of dysmenorrhea.,True,Is the triple 'Ibuprofen treats Dysmenorrhea' supported by the sentence: 'CONCLUSION: Continuous low-level topical heat therapy was as effective as ibuprofen for the treatment of dysmenorrhea.'?,"Yes, it is indirectly supported because both statements suggest that ibuprofen is an effective treatment for dysmenorrhea, even though they propose different methods of treatment (oral medication vs topical heat therapy)." -8698382,Ibuprofen treats Tension-type headache,1041,Is the combination of ibuprofen and caffeine effective for the treatment of a tension-type headache?,True,Is the triple 'Ibuprofen treats Tension-type headache' supported by the sentence: 'Is the combination of ibuprofen and caffeine effective for the treatment of a tension-type headache?'?,"Yes, it is indirectly supported because both statements refer to Ibuprofen being used for treating a type of headache, tension-type headaches, although they mention different forms of treatment (ibuprofen alone vs. a combination with caffeine)." -8452594,Ibuprofen treats migraine disorder,1042,"Evaluation of a novel solubilized formulation of ibuprofen in the treatment of migraine headache: a randomized, double-blind, placebo-controlled, dose-ranging study.",True,"Is the triple 'Ibuprofen treats migraine disorder' supported by the sentence: 'Evaluation of a novel solubilized formulation of ibuprofen in the treatment of migraine headache: a randomized, double-blind, placebo-controlled, dose-ranging study.'?","Yes, it is indirectly supported, as it suggests that ibuprofen can be used in treating migraines, but it does not explicitly state that it is a treatment for 'migraine disorder'." -8420965,Ibuprofen treats Hemorrhage,1043,"A randomized trial measuring fecal blood loss after treatment with rofecoxib, ibuprofen, or placebo in healthy subjects.",False,"Is the triple 'Ibuprofen treats Hemorrhage' supported by the sentence: 'A randomized trial measuring fecal blood loss after treatment with rofecoxib, ibuprofen, or placebo in healthy subjects.'?","No, it is not directly nor indirectly supported, as this study does not investigate hemorrhage, but rather measures fecal blood loss in healthy subjects treated with rofecoxib, ibuprofen, or placebo, without specifying any particular therapeutic effect on hemorrhage for ibuprofen." -8397426,Ibuprofen treats rheumatoid arthritis,1044,Ibuprofen or aspirin in rheumatoid arthritis therapy.,True,Is the triple 'Ibuprofen treats rheumatoid arthritis' supported by the sentence: 'Ibuprofen or aspirin in rheumatoid arthritis therapy.'?,"Yes, it is indirectly supported because both Ibuprofen and aspirin can be used in therapy for rheumatoid arthritis, as suggested by the given sentence." -7887942,Ibuprofen treats osteoarthritis,1045,"DESIGN: Ginger extract was compared to placebo and Ibuprofen in patients with osteoarthritis of the hip or knee in a controlled, double blind, double dummy, cross-over study with a wash-out period of one week followed by three treatment periods in a randomized sequence, each of three weeks duration.",True,"Is the triple 'Ibuprofen treats osteoarthritis' supported by the sentence: 'DESIGN: Ginger extract was compared to placebo and Ibuprofen in patients with osteoarthritis of the hip or knee in a controlled, double blind, double dummy, cross-over study with a wash-out period of one week followed by three treatment periods in a randomized sequence, each of three weeks duration.'?","Yes, it is indirectly supported because it mentions that Ibuprofen is being studied in relation to osteoarthritis, but it does not explicitly state that Ibuprofen treats osteoarthritis." -7852264,Ibuprofen treats Headache,1046,"Besides oxygen, acetazolamide, dexamethasone and especially inhibitors of prostaglandin synthesis such as ibuprofen and naproxen are approved for the treatment of HAH.",True,"Is the triple 'Ibuprofen treats Headache' supported by the sentence: 'Besides oxygen, acetazolamide, dexamethasone and especially inhibitors of prostaglandin synthesis such as ibuprofen and naproxen are approved for the treatment of HAH.'?","Yes, the statement is indirectly supported because ibuprofen is mentioned as an inhibitor of prostaglandin synthesis that is approved for treating HAH (High Altitude Headaches), which is a type of headache." -7851777,Ibuprofen treats patent ductus arteriosus,1047,OBJECTIVE: To evaluate the effect of intravenous ibuprofen and indomethacin for treatment of patent ductus arteriosus (PDA) on mesenteric and renal blood flow velocity in preterm infants.,True,Is the triple 'Ibuprofen treats patent ductus arteriosus' supported by the sentence: 'OBJECTIVE: To evaluate the effect of intravenous ibuprofen and indomethacin for treatment of patent ductus arteriosus (PDA) on mesenteric and renal blood flow velocity in preterm infants.'?,"Yes, it is indirectly supported because both ibuprofen and indomethacin are being studied for their effect on treating patent ductus arteriosus (PDA) in preterm infants, which suggests that ibuprofen could potentially be used for this purpose. However, it does not directly state that ibuprofen treats PDA, but rather that it's being studied for this effect." -7732956,Ibuprofen treats Pain,1048,"The WOMAC detected significant differences between ibuprofen and placebo for pain and physical functioning, whereas the SF-36 detected differences for the bodily pain subscale.",True,"Is the triple 'Ibuprofen treats Pain' supported by the sentence: 'The WOMAC detected significant differences between ibuprofen and placebo for pain and physical functioning, whereas the SF-36 detected differences for the bodily pain subscale.'?","Yes, it is indirectly supported. The first part of your statement, 'ibuprofen treats pain', is supported by the fact that both the WOMAC (Western Ontario and McMaster Universities Osteoarthritis Index) and SF-36 (Short Form Health Survey) detected significant differences in pain when comparing ibuprofen to a placebo, indicating that ibuprofen has a pain-relieving effect." -7686895,Ibuprofen treats arthritic joint disease,1049,"I take ibuprofen regularly for my arthritis, but I've heard that it may lead to kidney damage.",True,"Is the triple 'Ibuprofen treats arthritic joint disease' supported by the sentence: 'I take ibuprofen regularly for my arthritis, but I've heard that it may lead to kidney damage.'?","Yes, it is indirectly supported. The statement ""I take ibuprofen regularly for my arthritis, but I've heard that it may lead to kidney damage"" implies that ibuprofen is effective in treating arthritis (as indicated by your regular use), but it also suggests that there may be potential side effects, such as kidney damage, which is a type of joint disease. Therefore, it supports the idea that ibuprofen treats arthritic joint disease, but also highlights a potential risk associated with its use." -7258310,Ibuprofen treats Fever,1050,Paracetamol or ibuprofen in febrile children.,True,Is the triple 'Ibuprofen treats Fever' supported by the sentence: 'Paracetamol or ibuprofen in febrile children.'?,"Yes, it is indirectly supported. The provided sentence suggests that either Paracetamol or Ibuprofen can be used in febrile children, implying that Ibuprofen is effective in treating fever, which aligns with the statement ""Ibuprofen treats fever"". However, it's important to note that this is an indirect interpretation, as the original sentence does not explicitly state that Ibuprofen treats fever." -24973247,Methylprednisolone causes lupus nephritis,2,Evaluation of granulated fenbendazole (22.2%) against induced and naturally occurring helminth infections in cats.,False,Is the triple 'Methylprednisolone causes lupus nephritis' supported by the sentence: 'Evaluation of granulated fenbendazole (22.2%) against induced and naturally occurring helminth infections in cats.'?,"No, that statement does not provide support for the claim that Methylprednisolone causes lupus nephritis in any way, directly or indirectly." -26452786,Fenbendazole causes helminthiasis,3,Symptoms of perianal itching and visualization of visible motile worms persisted for 6 months despite being treated with multiple courses of albendazole causing a lot of frustration and distress to the caregivers.,False,Is the triple 'Fenbendazole causes helminthiasis' supported by the sentence: 'Symptoms of perianal itching and visualization of visible motile worms persisted for 6 months despite being treated with multiple courses of albendazole causing a lot of frustration and distress to the caregivers.'?,"No, this statement does not support the claim that Fenbendazole causes helminthiasis. The sentence mentions treatment with albendazole, not fenbendazole, and does not provide any information about fenbendazole's effects." -21848143,Albendazole causes helminthiasis,4,"CONCLUSIONS: Ibuprofen-induced patent ductus arteriosus closure improved pulmonary mechanics, decreased total lung water, increased epithelial sodium channel expression, and decreased the detrimental effects of preterm birth on alveolarization.",False,"Is the triple 'Albendazole causes helminthiasis' supported by the sentence: 'CONCLUSIONS: Ibuprofen-induced patent ductus arteriosus closure improved pulmonary mechanics, decreased total lung water, increased epithelial sodium channel expression, and decreased the detrimental effects of preterm birth on alveolarization.'?","No, this statement does not provide any support for the claim that Albendazole causes helminthiasis, as it discusses the effects of ibuprofen on patent ductus arteriosus closure, pulmonary mechanics, total lung water, epithelial sodium channel expression, and preterm birth effects on alveolarization." -13726345,Ibuprofen causes patent ductus arteriosus,5,Protein profile in neuroblastoma cells incubated with S- and R-enantiomers of ibuprofen by iTRAQ-coupled 2-D LC-MS/MS analysis: possible action of induced proteins on Alzheimer's disease.,False,Is the triple 'Ibuprofen causes patent ductus arteriosus' supported by the sentence: 'Protein profile in neuroblastoma cells incubated with S- and R-enantiomers of ibuprofen by iTRAQ-coupled 2-D LC-MS/MS analysis: possible action of induced proteins on Alzheimer's disease.'?,"No, that statement is not directly or even indirectly supportive of ibuprofen causing patent ductus arteriosus. The title you provided discusses the protein profile in neuroblastoma cells incubated with ibuprofen enantiomers, and possible actions of induced proteins on Alzheimer's disease, which is unrelated to patent ductus arteriosus, a congenital heart defect." -13653982,Ibuprofen causes Alzheimer disease,6,Protective effect of glucosamine against ibuprofen-induced peptic ulcer in rats.,False,Is the triple 'Ibuprofen causes Alzheimer disease' supported by the sentence: 'Protective effect of glucosamine against ibuprofen-induced peptic ulcer in rats.'?,"No, this statement does not provide any support for a link between ibuprofen and Alzheimer's disease. The protective effect of glucosamine against ibuprofen-induced peptic ulcer in rats is related to gastrointestinal side effects, not neurological effects." -13133316,Ibuprofen causes peptic ulcer disease,7,Ibuprofen-induced fever in Sjogren's syndrome.,False,Is the triple 'Ibuprofen causes peptic ulcer disease' supported by the sentence: 'Ibuprofen-induced fever in Sjogren's syndrome.'?,"No, it is not directly or indirectly supported because it does not mention anything about peptic ulcers, which is a crucial component of your original statement about Ibuprofen causing this condition. The given sentence talks about Ibuprofen inducing a fever in Sjogren's syndrome, which is an entirely different medical issue." -12641386,Ibuprofen causes Fever,8,There have been no prior definite cases reported of ibuprofen-induced pancreatitis.,False,Is the triple 'Ibuprofen causes Fever' supported by the sentence: 'There have been no prior definite cases reported of ibuprofen-induced pancreatitis.'?,"No, it is not directly or indirectly supported because pancreatitis is not fever, although fever can be a symptom in some conditions, it is not necessarily linked to pancreatitis caused by ibuprofen use." -12482174,Ibuprofen causes pancreatitis,9,"RESULTS: None of the studies established any of the COX-2 inhibitors as clearly better than ibuprofen, the current gold standard for the treatment of surgically induced dental pain.",False,"Is the triple 'Ibuprofen causes pancreatitis' supported by the sentence: 'RESULTS: None of the studies established any of the COX-2 inhibitors as clearly better than ibuprofen, the current gold standard for the treatment of surgically induced dental pain.'?","No, it is not directly or indirectly supported by that sentence, as it does not mention anything about ibuprofen causing pancreatitis. It simply states that ibuprofen is as effective as other COX-2 inhibitors in treating dental pain, implying that it is a standard treatment option, but not providing information about potential side effects or complications such as pancreatitis." -12438812,Ibuprofen causes Toothache,10,Noncardiogenic pulmonary edema due to ibuprofen.,False,Is the triple 'Ibuprofen causes Toothache' supported by the sentence: 'Noncardiogenic pulmonary edema due to ibuprofen.'?,"No, it is not directly or indirectly supported. Noncardiogenic pulmonary edema is a potential side effect of ibuprofen, but it does not imply that ibuprofen causes toothache." -12079834,Ibuprofen causes adult acute respiratory distress syndrome,11,"In a double-blind cross-over study on 22 healthy subjects the analgesic efficacies of the antipyretic analgesic drugs ibuprofen, dipyrone and paracetamol were tested against placebo using a model of experimentally induced pain.",False,"Is the triple 'Ibuprofen causes adult acute respiratory distress syndrome' supported by the sentence: 'In a double-blind cross-over study on 22 healthy subjects the analgesic efficacies of the antipyretic analgesic drugs ibuprofen, dipyrone and paracetamol were tested against placebo using a model of experimentally induced pain.'?","No, this statement does not provide any evidence to support the claim that ibuprofen causes adult acute respiratory distress syndrome, directly or indirectly. It discusses a study on the analgesic efficacy of ibuprofen, dipyrone, paracetamol, and placebo, but it does not mention anything about respiratory distress syndrome." -11157616,Ibuprofen causes Pain,12,Unaltered ibuprofen-induced faecal blood loss upon coadministration of moclobemide.,False,Is the triple 'Ibuprofen causes Pain' supported by the sentence: 'Unaltered ibuprofen-induced faecal blood loss upon coadministration of moclobemide.'?,"No, this statement does not provide direct support for the claim that Ibuprofen causes pain. It suggests a possible gastrointestinal side effect (faecal blood loss) when Ibuprofen is coadministered with moclobemide, but it does not establish a causative link between Ibuprofen and pain." -10429873,Ibuprofen causes Hemorrhage,13,The C5a antagonist (1 or 3 mg/kg/day) and/or ibuprofen (30 mg/kg/day) were administered orally on a daily basis either before or after arthritis induction.,False,Is the triple 'Ibuprofen causes Hemorrhage' supported by the sentence: 'The C5a antagonist (1 or 3 mg/kg/day) and/or ibuprofen (30 mg/kg/day) were administered orally on a daily basis either before or after arthritis induction.'?,"No, this statement does not support the claim that ibuprofen causes hemorrhage, directly or indirectly. It simply states that ibuprofen was administered in a study, without specifying any adverse effects such as hemorrhaging." -9800201,Ibuprofen causes arthritic joint disease,14,RESULTS: Ketoprofen 50 mg t.d.s. suppressed prostaglandin synthesis to a significantly greater extent than ibuprofen and caused significantly more gastroduodenal injury.,True,Is the triple 'Ibuprofen causes arthritic joint disease' supported by the sentence: 'RESULTS: Ketoprofen 50 mg t.d.s. suppressed prostaglandin synthesis to a significantly greater extent than ibuprofen and caused significantly more gastroduodenal injury.'?,"Yes, it is indirectly supported. The study found that ketoprofen caused significantly more gastroduodenal injury than ibuprofen, which could potentially contribute to arthritic joint disease over time due to gastrointestinal damage. However, this is an interpretation of the results and not a direct statement from the text you provided." -8163776,Ibuprofen causes injury,15,"Preclinical studies of ivabradine in animal models with induced AF demonstrated a reduction in HR, with no significant worsening of QT interval or mean arterial pressure.",False,"Is the triple 'Ibuprofen causes injury' supported by the sentence: 'Preclinical studies of ivabradine in animal models with induced AF demonstrated a reduction in HR, with no significant worsening of QT interval or mean arterial pressure.'?","No, it is not directly or indirectly supported because ibuprofen and ivabradine are different substances, with different mechanisms of action, and preclinical studies on ivabradine do not provide evidence for ibuprofen causing injury." -19228519,Ivabradine causes atrial fibrillation,16,Ranolazine was more effective than lidocaine in terminating persistent AF and in preventing the induction of AF.,False,Is the triple 'Ivabradine causes atrial fibrillation' supported by the sentence: 'Ranolazine was more effective than lidocaine in terminating persistent AF and in preventing the induction of AF.'?,"No, this statement does not provide any support for Ivabradine causing atrial fibrillation (AF). The effectiveness of Ranolazine compared to Lidocaine in terminating AF and preventing its induction does not relate to Ivabradine's potential side effects." -13317799,Ranolazine causes atrial fibrillation,17,CONCLUSION: Dexamethasone or prednisolone were the easiest to induce steroid glaucoma when the patients had long-term use of steroid eyedrops.,False,Is the triple 'Ranolazine causes atrial fibrillation' supported by the sentence: 'CONCLUSION: Dexamethasone or prednisolone were the easiest to induce steroid glaucoma when the patients had long-term use of steroid eyedrops.'?,"No, it is not directly nor indirectly supported, as there is no mention of Ranolazine, atrial fibrillation, or any related factors in that sentence." -27055840,Prednisolone causes glaucoma,18,"Among 121 CK-analogs studied, CK-17, CK-101A and CK103A have been identified as promising anti-inflammatory agents as potent as prednisolone in inhibiting lens proteins-induced inflammation and twice as potent as prednisolone in inhibiting endotoxin-and IL-1-induced uveitis.",False,"Is the triple 'Prednisolone causes glaucoma' supported by the sentence: 'Among 121 CK-analogs studied, CK-17, CK-101A and CK103A have been identified as promising anti-inflammatory agents as potent as prednisolone in inhibiting lens proteins-induced inflammation and twice as potent as prednisolone in inhibiting endotoxin-and IL-1-induced uveitis.'?","No, this statement does not support the claim that Prednisolone causes glaucoma, directly or indirectly. It discusses the anti-inflammatory properties of Prednisolone and some other compounds, but it does not mention or imply any connection to glaucoma." -26677891,Prednisolone causes uveitis,19,Light and electron microscopy of prednisolone-induced nephropathy in rabbits.,False,Is the triple 'Prednisolone causes uveitis' supported by the sentence: 'Light and electron microscopy of prednisolone-induced nephropathy in rabbits.'?,"No, it is not directly or indirectly supported, because there is no mention or implication in this sentence about prednisolone causing uveitis in rabbits or any other organism. The given statement specifically discusses a nephropathy (kidney disease) induced by prednisolone in rabbits, without any reference to its impact on ocular health (uveitis)." -25953223,Prednisolone causes kidney disorder,20,The behavior results showed that exposure to prednisolone resulted in decreased autonomic activity and low sensitivity to light.,False,Is the triple 'Prednisolone causes kidney disorder' supported by the sentence: 'The behavior results showed that exposure to prednisolone resulted in decreased autonomic activity and low sensitivity to light.'?,"No, it is not directly supported, as there is no explicit mention of a causal link between Prednisolone use, decreased autonomic activity, low sensitivity to light, and kidney disorders in this statement alone. However, it is possible for Prednisolone use to affect other bodily functions, which may in turn impact kidneys, but this would require further evidence from additional sources." -21556285,Prednisolone causes allergic disease,21,We therefore advocate for increased clinical alertness towards prednisolone-induced adrenal insufficiency in RTx patients and thus their potential need of rescue GC supplementation during stress.,True,Is the triple 'Prednisolone causes allergic disease' supported by the sentence: 'We therefore advocate for increased clinical alertness towards prednisolone-induced adrenal insufficiency in RTx patients and thus their potential need of rescue GC supplementation during stress.'?,"Yes, it is indirectly supported. The statement suggests that there is a risk of adrenal insufficiency in patients taking Prednisolone, which could potentially trigger an immune response or exacerbate existing allergic conditions due to the body's reduced ability to respond to stress. However, it does not directly state that Prednisolone causes allergic diseases, but rather implies a potential indirect relationship through adrenal insufficiency." -21293782,Prednisolone causes adrenocortical insufficiency,22,Zeaxanthin (50 mg/kg/day) or prednisolone (5 mg/kg/day) was orally administered for 14 days before induction of ulcerative colitis.,False,Is the triple 'Prednisolone causes adrenocortical insufficiency' supported by the sentence: 'Zeaxanthin (50 mg/kg/day) or prednisolone (5 mg/kg/day) was orally administered for 14 days before induction of ulcerative colitis.'?,"No, it is not directly supported because there is no mention of prednisolone causing adrenocortical insufficiency in this sentence. It simply states that prednisolone was administered, but it does not specify any resulting effects on the adrenal cortex system." -20789636,Prednisolone causes ulcerative colitis,23,"OBJECTIVE: We want to show that an intralesional injection of prednisolone into the proximal nail fold may produce dorsal pain, dyspnoea and headaches within the 2 min following the injection and to explain the pathophysiology of his condition.",False,"Is the triple 'Prednisolone causes ulcerative colitis' supported by the sentence: 'OBJECTIVE: We want to show that an intralesional injection of prednisolone into the proximal nail fold may produce dorsal pain, dyspnoea and headaches within the 2 min following the injection and to explain the pathophysiology of his condition.'?","No, it is not directly nor indirectly supported, as there is no mention of ulcerative colitis in this given statement, nor any correlation between prednisolone injections, dorsal pain, dyspnoea, headaches, and ulcerative colitis mentioned in this statement." -17230021,Prednisolone causes Headache,24,[A case of nephrotic syndrome with abnormally high level of protein C induced by prednisolone].,False,Is the triple 'Prednisolone causes Headache' supported by the sentence: '[A case of nephrotic syndrome with abnormally high level of protein C induced by prednisolone].'?,"No, it is not directly or indirectly supported by that sentence. The provided sentence discusses a case of nephrotic syndrome induced by prednisolone, but it does not mention anything about headaches being a side effect." -16304261,Prednisolone causes nephrotic syndrome,25,It is concluded that six or more cycles of COPP chemotherapy for advanced Hodgkin's disease in men leads to permanent sterility.,False,Is the triple 'Prednisolone causes nephrotic syndrome' supported by the sentence: 'It is concluded that six or more cycles of COPP chemotherapy for advanced Hodgkin's disease in men leads to permanent sterility.'?,"No, it's not directly related. The sentence discusses the effect of COPP chemotherapy on sterility in men with advanced Hodgkin's disease, while the statement about Prednisolone causing nephrotic syndrome involves a different subject altogether." -15365269,Prednisolone causes infertility disorder,26,The erythroderma improved generally as a result of systemic prednisolone treatment.,False,Is the triple 'Prednisolone causes infertility disorder' supported by the sentence: 'The erythroderma improved generally as a result of systemic prednisolone treatment.'?,"No, it is not directly supported because there is no explicit mention of an effect on fertility in the provided statement about prednisolone treating erythroderma." -14373522,Prednisolone causes exfoliative dermatitis,27,CONTACT DERMATITIS DUE TO TOPICAL HYDROCORTISONE AND PREDNISOLONE.,True,Is the triple 'Prednisolone causes exfoliative dermatitis' supported by the sentence: 'CONTACT DERMATITIS DUE TO TOPICAL HYDROCORTISONE AND PREDNISOLONE.'?,"Yes, it is indirectly supported because both Prednisolone and Hydrocortisone are mentioned as causing contact dermatitis, which is a type of skin reaction similar to exfoliative dermatitis. However, it does not directly state that Prednisolone causes exfoliative dermatitis." -10735861,Prednisolone causes contact dermatitis,28,[Pulmonary tuberculosis due to prednisolone].,False,Is the triple 'Prednisolone causes contact dermatitis' supported by the sentence: '[Pulmonary tuberculosis due to prednisolone].'?,"No, it is not directly supported because pulmonary tuberculosis is not a type of contact dermatitis. However, it could be interpreted as an adverse effect of Prednisolone use, which might increase the risk of various skin conditions including contact dermatitis." -10545904,Prednisolone causes pulmonary tuberculosis,29,"Rats were treated with a leukotriene synthesis inhibitor (PF-5901), a leukotriene B4 receptor antagonist (SC-41930), an IL-1 receptor antagonist or a corticosteroid (prednisolone) prior to induction of colitis.",False,"Is the triple 'Prednisolone causes pulmonary tuberculosis' supported by the sentence: 'Rats were treated with a leukotriene synthesis inhibitor (PF-5901), a leukotriene B4 receptor antagonist (SC-41930), an IL-1 receptor antagonist or a corticosteroid (prednisolone) prior to induction of colitis.'?","No, it is not directly supported because it does not mention any link between Prednisolone and pulmonary tuberculosis in this context." -10519611,Prednisolone causes colitis,30,"PURPOSE: To investigate the relationship between vitamin E deficiency and prednisolone-induced cataract formation, long-term examination of lens changes was performed in rats under the condition of vitamin E deficiency or supplementation and administration of prednisolone.",False,"Is the triple 'Prednisolone causes colitis' supported by the sentence: 'PURPOSE: To investigate the relationship between vitamin E deficiency and prednisolone-induced cataract formation, long-term examination of lens changes was performed in rats under the condition of vitamin E deficiency or supplementation and administration of prednisolone.'?","No, it is not directly or indirectly supported. The given sentence is about an investigation of the relationship between vitamin E deficiency and prednisolone-induced cataract formation in rats, not about prednisolone causing colitis in any form." -9464043,Prednisolone causes cataract,31,"In inactive SLE induced by prednisolone therapy, the invariant Valpha24JalphaQ TCR could be detected in DN Valpha24+ T cells from all the patients and dominated in most of the patients.",False,"Is the triple 'Prednisolone causes cataract' supported by the sentence: 'In inactive SLE induced by prednisolone therapy, the invariant Valpha24JalphaQ TCR could be detected in DN Valpha24+ T cells from all the patients and dominated in most of the patients.'?","No, it is not directly or indirectly supported. The given sentence discusses an invariant Valpha24JalphaQ TCR detected in DN Valpha24+ T cells from patients with inactive Systemic Lupus Erythematosus (SLE) who were undergoing prednisolone therapy, but it doesn't mention any connection to cataracts." -8757881,Prednisolone causes systemic lupus erythematosus,32,"The suppression of the anti-inflammatory effects of cortisol as a result of states of excessive stress leads to hypercatabolic diseases such as AIDS, sepsis and toxic shock syndrome and protein calorie malnutrition (NAIDS).",False,"Is the triple 'Prednisolone causes systemic lupus erythematosus' supported by the sentence: 'The suppression of the anti-inflammatory effects of cortisol as a result of states of excessive stress leads to hypercatabolic diseases such as AIDS, sepsis and toxic shock syndrome and protein calorie malnutrition (NAIDS).'?","No, this statement does not provide direct support for the idea that Prednisolone, a corticosteroid medication used to suppress inflammation, causes systemic lupus erythematosus (SLE), an autoimmune disease. The statement discusses the negative effects of cortisol suppression due to excessive stress, leading to hypercatabolic diseases, but it does not mention Prednisolone or SLE." -27747116,Hydrocortisone causes toxic shock syndrome,33,"The suppression of the anti-inflammatory effects of cortisol as a result of states of excessive stress leads to hypercatabolic diseases such as AIDS, sepsis and toxic shock syndrome and protein calorie malnutrition (NAIDS).",False,"Is the triple 'Hydrocortisone causes toxic shock syndrome' supported by the sentence: 'The suppression of the anti-inflammatory effects of cortisol as a result of states of excessive stress leads to hypercatabolic diseases such as AIDS, sepsis and toxic shock syndrome and protein calorie malnutrition (NAIDS).'?","No, it is not directly or indirectly supported, as Hydrocortisone is a synthetic form of cortisol, which is an anti-inflammatory hormone, and there is nothing in this statement suggesting that it would cause toxic shock syndrome, but rather that a lack of cortisol's effects could lead to certain hypercatabolic diseases, not Hydrocortisone itself causing them." -27747115,Hydrocortisone causes Sepsis,34,"We report the case of a 41-year-old nonatopic women with a previous history of eczematous reaction due to hydrocortisone who suffered worsening of her perennial rhinitis in association with perinasal dermatitis from the use of budesonide in nasal spray form, and stomatitis and pharyngitis due to budesonide in a bronchial inhaler.",False,"Is the triple 'Hydrocortisone causes Sepsis' supported by the sentence: 'We report the case of a 41-year-old nonatopic women with a previous history of eczematous reaction due to hydrocortisone who suffered worsening of her perennial rhinitis in association with perinasal dermatitis from the use of budesonide in nasal spray form, and stomatitis and pharyngitis due to budesonide in a bronchial inhaler.'?","No, this statement does not provide direct evidence to support that hydrocortisone causes sepsis, as it discusses adverse effects from budesonide, not hydrocortisone." -27073884,Hydrocortisone causes atopic eczema,35,"In this perspective paper, we focus on the neuro-endocrine interactions that occur between progesterone, allopregnanolone, and cortisol during pregnancy, and propose that they align with our previously proposed model of FM pathogenesis based on GABAergic ""weakening"" in a thalamocortical neural loop system.",False,"Is the triple 'Hydrocortisone causes atopic eczema' supported by the sentence: 'In this perspective paper, we focus on the neuro-endocrine interactions that occur between progesterone, allopregnanolone, and cortisol during pregnancy, and propose that they align with our previously proposed model of FM pathogenesis based on GABAergic ""weakening"" in a thalamocortical neural loop system.'?","No. The statement about Hydrocortisone causing atopic eczema is not directly or indirectly supported by the provided sentence as it discusses neuro-endocrine interactions between progesterone, allopregnanolone, and cortisol during pregnancy, but does not mention Hydrocortisone or atopic eczema." -25383174,Hydrocortisone causes fibromyalgia,36,The present study reported a case of hydrocortisone-induced blood pressure reduction in a patient with anterior pituitary hypofunction due to allergic reaction.,False,Is the triple 'Hydrocortisone causes fibromyalgia' supported by the sentence: 'The present study reported a case of hydrocortisone-induced blood pressure reduction in a patient with anterior pituitary hypofunction due to allergic reaction.'?,"No, this statement does not provide any support for the claim that Hydrocortisone causes fibromyalgia, directly or indirectly. The statement discusses a patient with anterior pituitary hypofunction due to allergic reaction who experienced blood pressure reduction after using Hydrocortisone, but it does not mention anything about fibromyalgia." -25205462,Hydrocortisone causes hypotensive disorder,37,Fetal adrenocorticotropic hormone and cortisol increased to peak values within 2.8 hours of induced hypoxia but by 7.2 hours had begun to fall to values that were not significantly different from those at 1.4 hours.,False,Is the triple 'Hydrocortisone causes hypotensive disorder' supported by the sentence: 'Fetal adrenocorticotropic hormone and cortisol increased to peak values within 2.8 hours of induced hypoxia but by 7.2 hours had begun to fall to values that were not significantly different from those at 1.4 hours.'?,"No, it is not directly supported because there is no mention of Hydrocortisone in the provided sentence. However, it does suggest a relationship between hypoxia, cortisol, and time, which could potentially be related to the effects of Hydrocortisone on blood pressure, but this would be an indirect relationship that would require further evidence to establish." -20591759,Hydrocortisone causes Hypoxemia,38,Congenital adrenal hyperplasia (CAH) is a chronic condition and individuals are exposed to elevated androgen levels in utero as a result of the endogenous cortisol deficiency.,True,Is the triple 'Hydrocortisone causes Hypoxemia' supported by the sentence: 'Congenital adrenal hyperplasia (CAH) is a chronic condition and individuals are exposed to elevated androgen levels in utero as a result of the endogenous cortisol deficiency.'?,"Yes, there is an indirect connection between these two statements, but it's important to clarify that hydrocortisone does not directly cause hypoxemia (low oxygen levels in the blood). However, congenital adrenal hyperplasia (CAH) can lead to elevated androgen levels in utero due to endogenous cortisol deficiency, as mentioned in your statement. This condition is often treated with hydrocortisone to manage cortisol levels, which in turn helps control androgen levels. If left untreated, CAH can lead to various complications, including respiratory issues, but it's crucial to note that hydrocortisone itself does not cause hypoxemia." -18446972,Hydrocortisone causes congenital adrenal hyperplasia,39,The results of our study confirm that thymol has strong ameliorative effect against hydrocortisone-induced oxidative stress injury in hepatic tissues.,False,Is the triple 'Hydrocortisone causes congenital adrenal hyperplasia' supported by the sentence: 'The results of our study confirm that thymol has strong ameliorative effect against hydrocortisone-induced oxidative stress injury in hepatic tissues.'?,"No, this statement does not provide any support for hydrocortisone causing congenital adrenal hyperplasia. It discusses the effects of thymol on hydrocortisone-induced oxidative stress injury in hepatic tissues, not its role in causing congenital adrenal hyperplasia." -18240145,Hydrocortisone causes injury,40,The effects of 8-bromo-cyclic AMP and cyclic AMP agonists (cholera toxin plus hydrocortisone and prostaglandin E2 plus 3-isobutyl-1-methylxanthine) on the cytotoxic activity of T cells generated during murine influenza virus infection have been examined.,False,Is the triple 'Hydrocortisone causes injury' supported by the sentence: 'The effects of 8-bromo-cyclic AMP and cyclic AMP agonists (cholera toxin plus hydrocortisone and prostaglandin E2 plus 3-isobutyl-1-methylxanthine) on the cytotoxic activity of T cells generated during murine influenza virus infection have been examined.'?,"No, it is not directly or indirectly supported. The statement does not imply any harm or injury caused by hydrocortisone, but rather discusses its role in a study about T cell activity during murine influenza virus infection." -17359303,Hydrocortisone causes influenza,41,Open oral provocation with 100 or 250 mg hydrocortisone in patients with hydrocortisone contact hypersensitivity elicited cutaneous reactions at sites of previous allergic dermatitis caused by hydrocortisone in two patients and at sites of earlier allergic patch test reactions caused by hydrocortisone in the other two patients.,False,Is the triple 'Hydrocortisone causes influenza' supported by the sentence: 'Open oral provocation with 100 or 250 mg hydrocortisone in patients with hydrocortisone contact hypersensitivity elicited cutaneous reactions at sites of previous allergic dermatitis caused by hydrocortisone in two patients and at sites of earlier allergic patch test reactions caused by hydrocortisone in the other two patients.'?,"No, the statement does not support a direct link between hydrocortisone use and causing influenza, as it discusses cutaneous reactions in patients with hydrocortisone contact hypersensitivity, not respiratory infections associated with influenza." -13585273,"Hydrocortisone causes dermatitis, atopic",42,"Although initial studies in transgenic mice and humans are encouraging, more data are required to conclusively prove the hypothesis that the adipose-tissue-specific overexpression of HSD1 and the resultant increase in tissue-specific cortisol concentrations result in human obesity, insulin resistance, high blood pressure, and metabolic syndrome.",False,"Is the triple 'Hydrocortisone causes dermatitis, atopic' supported by the sentence: 'Although initial studies in transgenic mice and humans are encouraging, more data are required to conclusively prove the hypothesis that the adipose-tissue-specific overexpression of HSD1 and the resultant increase in tissue-specific cortisol concentrations result in human obesity, insulin resistance, high blood pressure, and metabolic syndrome.'?","No, it is not directly or indirectly supported by that statement because it discusses obesity, insulin resistance, high blood pressure, and metabolic syndrome, not dermatitis or atopic conditions." -12645476,Hydrocortisone causes obesity disorder,43,"CONCLUSION: Although hydrocortisone has anti-inflammatory properties, it seems to provoke inflammation in the round window membrane after topical instillation.",False,"Is the triple 'Hydrocortisone causes obesity disorder' supported by the sentence: 'CONCLUSION: Although hydrocortisone has anti-inflammatory properties, it seems to provoke inflammation in the round window membrane after topical instillation.'?","No, it is not directly or indirectly supported because there is no mention of any relation to obesity in this statement about inflammation in the round window membrane after topical instillation of hydrocortisone." -10068843,Hydrocortisone causes Inflammation,44,"Type 2 glucocorticoid receptors (GRs), which are occupied by cortisol in humans in times of stress, are thought to be responsible for the glucocorticoid-induced memory impairment.",False,"Is the triple 'Hydrocortisone causes Inflammation' supported by the sentence: 'Type 2 glucocorticoid receptors (GRs), which are occupied by cortisol in humans in times of stress, are thought to be responsible for the glucocorticoid-induced memory impairment.'?","No, because Hydrocortisone is a type of cortisol, not a cause of inflammation. The statement discusses how cortisol (which includes Hydrocortisone) affects memory through type 2 GRs, not how it induces inflammation." -9850315,Hydrocortisone causes dissociative amnesia,45,"Firstly, the GH-mediated increase in cortisol metabolism (mediated via reduced E to F conversion) may precipitate adrenal insufficiency in hypopituitary patients with partial adrenocorticotropic hormone deficiency commencing GH therapy.",False,"Is the triple 'Hydrocortisone causes dissociative amnesia' supported by the sentence: 'Firstly, the GH-mediated increase in cortisol metabolism (mediated via reduced E to F conversion) may precipitate adrenal insufficiency in hypopituitary patients with partial adrenocorticotropic hormone deficiency commencing GH therapy.'?","No, it is not directly or indirectly supported. The given statement discusses how Growth Hormone (GH) therapy can affect cortisol metabolism in patients with partial adrenocorticotropic hormone deficiency, potentially leading to adrenal insufficiency due to reduced conversion of E to F (Estradiol to Estriol). However, it does not mention anything about Hydrocortisone causing dissociative amnesia." -9318796,Hydrocortisone causes adrenocortical insufficiency,46,"From this study it is inferred that the group III steroid betamethasone dipropionate alone heals experimentally induced external otitis more rapidly than hydrocortisone with oxytetracycline, with or without polymyxin B.",False,"Is the triple 'Hydrocortisone causes adrenocortical insufficiency' supported by the sentence: 'From this study it is inferred that the group III steroid betamethasone dipropionate alone heals experimentally induced external otitis more rapidly than hydrocortisone with oxytetracycline, with or without polymyxin B.'?","No, this statement does not support that hydrocortisone causes adrenocortical insufficiency. It compares the healing rates of different steroids when used to treat external otitis, but it does not mention any effects on adrenocortical function." -9145908,Hydrocortisone causes otitis externa,47,"In conclusion, the reciprocal expression of CYP17 and the transcriptional repressors COUP-TF and DAX-1 indicates that these orphan receptors have a pathophysiologic role in the excessive hormone production in cortisol- and deoxycorticosterone-producing adrenocortical tumors.",False,"Is the triple 'Hydrocortisone causes otitis externa' supported by the sentence: 'In conclusion, the reciprocal expression of CYP17 and the transcriptional repressors COUP-TF and DAX-1 indicates that these orphan receptors have a pathophysiologic role in the excessive hormone production in cortisol- and deoxycorticosterone-producing adrenocortical tumors.'?","No, it is not directly supported because there is no explicit mention in this statement about Hydrocortisone causing otitis externa. This statement discusses the role of certain receptors in excessive hormone production in adrenocortical tumors." -8699464,Hydrocortisone causes adrenal cortex neoplasm,48,"The administration of hydrocortisone before tumor inoculation resulted in increased tumor take, reduced mean survival time of mice, and concentration of tumor metastasis in a specific organ (i.e., lung metastasis for Ehrlich hypotetraploid clone 1 tumor, and liver metastasis for Ehrlich hypotetraploid stock and Ehrlich hyperdiploid stock tumors).",True,"Is the triple 'Hydrocortisone causes adrenal cortex neoplasm' supported by the sentence: 'The administration of hydrocortisone before tumor inoculation resulted in increased tumor take, reduced mean survival time of mice, and concentration of tumor metastasis in a specific organ (i.e., lung metastasis for Ehrlich hypotetraploid clone 1 tumor, and liver metastasis for Ehrlich hypotetraploid stock and Ehrlich hyperdiploid stock tumors).'?","Yes, this statement does provide some support for the idea that hydrocortisone could potentially have an impact on tumor growth and metastasis, which could be interpreted as a form of neoplasm (abnormal tissue growth). However, it does not directly state that hydrocortisone causes adrenal cortex neoplasm. It's also important to note that correlation does not imply causation, so further research would be needed to establish a direct cause-effect relationship." -8657746,Hydrocortisone causes neoplasm,49,"Cortisol counteracts the insulin activation of glycogen synthase in muscle, the insulin inhibition of hepatic glucose production and the insulin inhibition of lipolysis in adipose tissue, leading to the well-established systemic insulin resistance caused by excess cortisol.",False,"Is the triple 'Hydrocortisone causes neoplasm' supported by the sentence: 'Cortisol counteracts the insulin activation of glycogen synthase in muscle, the insulin inhibition of hepatic glucose production and the insulin inhibition of lipolysis in adipose tissue, leading to the well-established systemic insulin resistance caused by excess cortisol.'?","No, this statement does not provide evidence that Hydrocortisone, a specific type of cortisol, directly or indirectly causes neoplasm (a type of cancer). It discusses the effects of cortisol on various metabolic processes, but does not make a connection to neoplasm." -7929803,Hydrocortisone causes Insulin resistance,50,"The amount of N-acetyl D-glucosamine in the zymogen granule membrane was not altered by caerulein acute pancreatitis induced under continuous hydrocortisone treatment, but it was decreased by the administration of L-364,718 over 7 days after pancreatitis induction.",True,"Is the triple 'Hydrocortisone causes Insulin resistance' supported by the sentence: 'The amount of N-acetyl D-glucosamine in the zymogen granule membrane was not altered by caerulein acute pancreatitis induced under continuous hydrocortisone treatment, but it was decreased by the administration of L-364,718 over 7 days after pancreatitis induction.'?","Yes, it is indirectly supported because hydrocortisone did not affect N-acetyl D-glucosamine levels, but L-364,718, a compound known to increase insulin sensitivity, did decrease these levels after pancreatitis induction, suggesting a link between hydrocortisone, zymogen granule membrane changes, and potential insulin resistance. However, this is a complex biological system, and more research would be needed to confirm this relationship directly." -7432490,Hydrocortisone causes pancreatitis,51,"In this study, low-dose methylprednisolone (0.8 mg/kg/day, MP) was used to induce a steroid-resistant lupus nephritis (SR-LN) mouse model in weeks one to four, and a therapeutic steroid dosage (MP 12 mg/kg/day) or a combined PNS (PNS 100 mg/kg/day) treatment was administered from week five to eight.",False,"Is the triple 'Hydrocortisone causes pancreatitis' supported by the sentence: 'In this study, low-dose methylprednisolone (0.8 mg/kg/day, MP) was used to induce a steroid-resistant lupus nephritis (SR-LN) mouse model in weeks one to four, and a therapeutic steroid dosage (MP 12 mg/kg/day) or a combined PNS (PNS 100 mg/kg/day) treatment was administered from week five to eight.'?","No, because hydrocortisone is not mentioned in the provided sentence. The steroids mentioned in the sentence are methylprednisolone (MP) and PNS (Pentoxifylline)." +24413653,Fenbendazole treats helminthiasis,1001,"This study investigated worm control practices by free-range egg farmers and the efficacy of the commercial anthelmintics levamisole (LEV), piperazine (PIP), flubendazole (FLBZ) and fenbendazole (FBZ) against gastrointestinal nematodes on two free-range layer farms in Australia.",True,"Is the triple 'Fenbendazole treats helminthiasis' supported by the sentence: 'This study investigated worm control practices by free-range egg farmers and the efficacy of the commercial anthelmintics levamisole (LEV), piperazine (PIP), flubendazole (FLBZ) and fenbendazole (FBZ) against gastrointestinal nematodes on two free-range layer farms in Australia.'?","Yes, the statement 'Fenbendazole treats helminthiasis' is indirectly supported by the given sentence, as it mentions that fenbendazole (FBZ) was tested for its efficacy against gastrointestinal nematodes, which is a type of parasitic worm infection, also known as helminthiasis, on two free-range layer farms in Australia." +9783282,Thiabendazole treats helminthiasis,1002,[The treatment of helminthiasis with thiabendazole].,True,Is the triple 'Thiabendazole treats helminthiasis' supported by the sentence: '[The treatment of helminthiasis with thiabendazole].'?,"Yes, it is directly supported because the statement ""[The treatment of helminthiasis with thiabendazole]."" implies that thiabendazole is used to treat helminthiasis, which is what 'Thiabendazole treats helminthiasis' means." +22678969,Albendazole treats Infection,1003,The control of STH infections is based on preventive chemotherapy using either albendazole or mebendazole.,True,Is the triple 'Albendazole treats Infection' supported by the sentence: 'The control of STH infections is based on preventive chemotherapy using either albendazole or mebendazole.'?,"Yes, it is. The given sentence mentions that albendazole is used for preventive chemotherapy for Soil-Transmitted Helminth (STH) infections, which implies that albendazole can treat such infections, thus providing support for the statement, albeit indirectly as it does not directly mention that albendazole can treat an infection, but rather that it's used for chemotherapy to control them." +10750815,Albendazole treats onchocerciasis,1004,"A double-blind clinical trial was conducted in Monagas State, Venezuela to assess the tolerance and efficacy of albendazole in the therapy of Onchocerca volvulus infection.",True,"Is the triple 'Albendazole treats onchocerciasis' supported by the sentence: 'A double-blind clinical trial was conducted in Monagas State, Venezuela to assess the tolerance and efficacy of albendazole in the therapy of Onchocerca volvulus infection.'?","Yes, it is indirectly supported because a clinical trial with albendazole for Onchocerca volvulus infection (which is a type of onchocerciasis) shows that albendazole is being used as a treatment for this disease, even though it doesn't explicitly state that albendazole cures or eliminates it." +10114050,Albendazole treats toxocariasis,1005,"The treatment of cutaneous larva migrans and Toxocara infection relies on antihelminthic agents such as thiabendazole, albendazole and ivermectin.",True,"Is the triple 'Albendazole treats toxocariasis' supported by the sentence: 'The treatment of cutaneous larva migrans and Toxocara infection relies on antihelminthic agents such as thiabendazole, albendazole and ivermectin.'?","Yes, the statement 'The treatment of cutaneous larva migrans and Toxocara infection relies on antihelminthic agents such as thiabendazole, albendazole and ivermectin' does imply that albendazole is used in the treatment of Toxocara infection, which is a form of toxocariasis. Therefore, it does provide indirect support for the statement 'Albendazole treats toxocariasis'." +9588560,Albendazole treats trichuriasis,1006,"Three randomized clinical studies were conducted in 2000 to evaluate the efficacy of nitazoxanide paediatric suspension compared to albendazole in the treatment of ascariasis and trichuriasis and praziquantel in the treatment of hymenolepiasis in children from Cajamarca, Peru.",True,"Is the triple 'Albendazole treats trichuriasis' supported by the sentence: 'Three randomized clinical studies were conducted in 2000 to evaluate the efficacy of nitazoxanide paediatric suspension compared to albendazole in the treatment of ascariasis and trichuriasis and praziquantel in the treatment of hymenolepiasis in children from Cajamarca, Peru.'?","Yes, it is indirectly supported because it mentions that albendazole is used to treat trichuriasis, but it does not directly support that albendazole specifically treats trichuriasis better than other treatments, as mentioned in the given sentence." +9492446,Albendazole treats filariasis,1007,"Today, the only way is the prophylactic control of Onchocerca vovulus infections and treating lymphatic filariosis with ivermectin, diethylcarbamacine, ivermectin/diethylcarbamazine. or ivermectin/albendazole combinations.",True,"Is the triple 'Albendazole treats filariasis' supported by the sentence: 'Today, the only way is the prophylactic control of Onchocerca vovulus infections and treating lymphatic filariosis with ivermectin, diethylcarbamacine, ivermectin/diethylcarbamazine. or ivermectin/albendazole combinations.'?","Yes, it is indirectly supported because albendazole is mentioned as a treatment option for lymphatic filariosis in combination with ivermectin. However, it's important to note that the primary treatment mentioned for Onchocerca volvulus infections is ivermectin, not albendazole." +8712067,Albendazole treats helminthiasis,1008,The study population was assessed for helminthic infection and those found to be positive were randomly assigned to either an albendazole treatment group or a control group who received a placebo.,True,Is the triple 'Albendazole treats helminthiasis' supported by the sentence: 'The study population was assessed for helminthic infection and those found to be positive were randomly assigned to either an albendazole treatment group or a control group who received a placebo.'?,"Yes, the statement does provide indirect support to the claim that Albendazole treats helminthiasis. The fact that individuals with a helminthic infection were given Albendazole as part of a treatment group suggests that Albendazole is used to treat such infections, which is what 'helminthiasis' refers to." +7789677,Albendazole treats strongyloidiasis,1009,"To determine the host factors involved in response to treatment, 46 patients with strongyloidiasis were treated with albendazole, followed-up for 1 year, and separated into two groups: cured and non-cured.",True,"Is the triple 'Albendazole treats strongyloidiasis' supported by the sentence: 'To determine the host factors involved in response to treatment, 46 patients with strongyloidiasis were treated with albendazole, followed-up for 1 year, and separated into two groups: cured and non-cured.'?","Yes, it is indirectly supported because it mentions that patients with strongyloidiasis were treated with albendazole, implying that albendazole is used to treat this condition. However, it does not explicitly state that albendazole treats strongyloidiasis, hence it's an indirect support." +7640018,Albendazole treats filarial elephantiasis,1010,The role of albendazole in programmes to eliminate lymphatic filariasis.,True,Is the triple 'Albendazole treats filarial elephantiasis' supported by the sentence: 'The role of albendazole in programmes to eliminate lymphatic filariasis.'?,"Yes, it is indirectly supported. The statement you provided suggests that Albendazole is used in programs to eliminate lymphatic filariasis, which is a type of filarial disease. Therefore, it can be inferred that Albendazole is indeed used to treat filarial diseases, even though elephantiasis is not explicitly mentioned." +7620262,Albendazole treats Hookworm Infections,1011,On the basis of our results the single 400 mg dose of albendazole is the treatment of choice for hookworm infections in this region of Mali.,True,Is the triple 'Albendazole treats Hookworm Infections' supported by the sentence: 'On the basis of our results the single 400 mg dose of albendazole is the treatment of choice for hookworm infections in this region of Mali.'?,"Yes, the statement ""Albendazole treats Hookworm Infections"" is generally true, as shown in the study's results that support using a single 400mg dose of albendazole as the treatment of choice for hookworm infections in that specific region of Mali. However, it's important to note that treatment effectiveness might vary depending on factors such as geographical location, severity of infection, patient characteristics, and drug resistance, among others." +7226097,Albendazole treats cysticercosis,1012,The efficacy of albendazole (15 mg/kg/d for 1 week) was compared with praziquantel (100 mg/kg in three divided doses at 2-hour intervals) for therapy of parenchymal brain cysticercosis.,True,Is the triple 'Albendazole treats cysticercosis' supported by the sentence: 'The efficacy of albendazole (15 mg/kg/d for 1 week) was compared with praziquantel (100 mg/kg in three divided doses at 2-hour intervals) for therapy of parenchymal brain cysticercosis.'?,"Yes, it is indirectly supported because both Albendazole and Praziquantel were used to treat parenchymal brain cysticercosis, implying that Albendazole is used to treat this condition. However, it doesn't directly state that Albendazole treats cysticercosis, but rather it implies it." +25678577,Latamoxef treats bacterial infectious disease,1013,"Clinical efficacy and safety of a new oxacephem, moxalactam, in serious bacterial infections.",True,"Is the triple 'Latamoxef treats bacterial infectious disease' supported by the sentence: 'Clinical efficacy and safety of a new oxacephem, moxalactam, in serious bacterial infections.'?","Yes, it is indirectly supported because Latamoxef is an oxacephem, like moxalactam, which is used to treat serious bacterial infections, as mentioned in the study you cited. However, it's important to note that this doesn't directly prove that Latamoxef specifically is effective against bacterial infections, as different oxacephems may have different properties and effectiveness against various bacteria." +26824955,Ibuprofen treats spondylosis,1014,A comparison of the short-term effects of ibuprofen and diclofenac in spondylosis.,True,Is the triple 'Ibuprofen treats spondylosis' supported by the sentence: 'A comparison of the short-term effects of ibuprofen and diclofenac in spondylosis.'?,"Yes, it is indirectly supported because both sentences discuss the relationship between Ibuprofen and spondylosis, although they do not make a direct claim about Ibuprofen treating it." +25670779,Ibuprofen treats sunburn,1015,"The data suggest that ibuprofen is more effective than placebo for the relief of symptoms associated with UV-B-induced inflammation after high dose UV-B phototherapy for psoriasis, but the drug has limited usefulness in the treatment of sunburn reaction from these same doses.",True,"Is the triple 'Ibuprofen treats sunburn' supported by the sentence: 'The data suggest that ibuprofen is more effective than placebo for the relief of symptoms associated with UV-B-induced inflammation after high dose UV-B phototherapy for psoriasis, but the drug has limited usefulness in the treatment of sunburn reaction from these same doses.'?","Yes, it can be interpreted as indirect support, as it mentions Ibuprofen's effectiveness in relieving symptoms associated with UV-B-induced inflammation, which can be a result of sunburn. However, it also states that Ibuprofen has limited usefulness in treating sunburn reaction from these same doses, which could be interpreted as not directly supporting the statement." +25518118,Ibuprofen treats Fractured ankle,1016,"Huoxue Huayu Recipe combined with ibuprofen can reduce inflammatory factors levels in patients with ankle fracture, improve isokinetic muscle strength and ankle function, and accelerate the recovery of patients.",True,"Is the triple 'Ibuprofen treats Fractured ankle' supported by the sentence: 'Huoxue Huayu Recipe combined with ibuprofen can reduce inflammatory factors levels in patients with ankle fracture, improve isokinetic muscle strength and ankle function, and accelerate the recovery of patients.'?","Yes, it is indirectly supported. The given sentence suggests that ibuprofen, when used in combination with a specific recipe, can help reduce inflammation, improve muscle strength, and enhance recovery in patients with ankle fractures. However, it does not explicitly state that ibuprofen alone can treat a fractured ankle, but it does imply that it can contribute to the overall treatment process." +25321029,Ibuprofen treats bronchopulmonary dysplasia,1017,"Treatment of newborn rat pups with ibuprofen reduced pulmonary vessel density in the developing lung, but also attenuated experimental BPD by reducing lung inflammation, alveolar enlargement, alveolar septum thickness and small arteriolar wall thickening.",True,"Is the triple 'Ibuprofen treats bronchopulmonary dysplasia' supported by the sentence: 'Treatment of newborn rat pups with ibuprofen reduced pulmonary vessel density in the developing lung, but also attenuated experimental BPD by reducing lung inflammation, alveolar enlargement, alveolar septum thickness and small arteriolar wall thickening.'?","Yes, this statement does provide some indirect support for the idea that ibuprofen can treat bronchopulmonary dysplasia (BPD). The statement mentions that ibuprofen treatment in rat pups reduced lung inflammation, alveolar enlargement, alveolar septum thickness, and small arteriolar wall thickening, which are all factors associated with BPD. Therefore, it suggests that ibuprofen could potentially be used to treat BPD. However, it's important to note that this is based on a study in rat pups, not humans, so further research would be needed to confirm these findings in humans." +22125431,Ibuprofen treats preeclampsia,1018,Introduction: The comparison of ibuprofen with acetaminophen for blood pressure (BP) in preeclampsia remains controversial.,False,Is the triple 'Ibuprofen treats preeclampsia' supported by the sentence: 'Introduction: The comparison of ibuprofen with acetaminophen for blood pressure (BP) in preeclampsia remains controversial.'?,"No, it is not directly nor indirectly supported because the given sentence discusses a controversy between ibuprofen and acetaminophen, not specifically addressing whether ibuprofen treats preeclampsia." +21268743,Ibuprofen treats glioma,1019,"Taken together, our findings reveal that ibuprofen could induce ferroptosis of glioblastoma cells via downregulation of Nrf2 signaling pathway and is a potential drug for glioma treatment.",True,"Is the triple 'Ibuprofen treats glioma' supported by the sentence: 'Taken together, our findings reveal that ibuprofen could induce ferroptosis of glioblastoma cells via downregulation of Nrf2 signaling pathway and is a potential drug for glioma treatment.'?","Yes, it is indirectly supported. The statement suggests that Ibuprofen could potentially be used in treating gliomas (glioblastoma is a type of glioma) due to its ability to induce ferroptosis in these cells through downregulation of Nrf2 signaling pathway." +20821983,Ibuprofen treats common cold,1020,Ibuprofen (IBU) and phenylephrine hydrochloride (PE) were commonly used for common cold due to their different effects in relieving fever and the main symptoms such as nasal congestion and high sinus pressure.,True,Is the triple 'Ibuprofen treats common cold' supported by the sentence: 'Ibuprofen (IBU) and phenylephrine hydrochloride (PE) were commonly used for common cold due to their different effects in relieving fever and the main symptoms such as nasal congestion and high sinus pressure.'?,"Yes, it is indirectly supported because it mentions that Ibuprofen is used for treating symptoms of the common cold, even though it doesn't explicitly state that Ibuprofen treats the common cold itself." +20285347,Ibuprofen treats periodontitis,1021,"Therefore, the objective of this study was to investigate the local delivery of the NSAIDs model drug ibuprofen to treat periodontitis using different types of gel formulations (hydrogel, oleogel, and bigel).",True,"Is the triple 'Ibuprofen treats periodontitis' supported by the sentence: 'Therefore, the objective of this study was to investigate the local delivery of the NSAIDs model drug ibuprofen to treat periodontitis using different types of gel formulations (hydrogel, oleogel, and bigel).'?","Yes, it is indirectly supported because the statement suggests a scientific investigation into using ibuprofen in different gel formulations for treating periodontitis. However, it does not directly confirm that ibuprofen can treat periodontitis as it is a statement from a hypothetical scientific investigation's objectives." +19270581,Ibuprofen treats bone fracture,1022,Does the Use of Ibuprofen in Children with Extremity Fractures Increase their Risk for Bone Healing Complications?,False,Is the triple 'Ibuprofen treats bone fracture' supported by the sentence: 'Does the Use of Ibuprofen in Children with Extremity Fractures Increase their Risk for Bone Healing Complications?'?,"No, it is not directly supported because the original statement suggests that ibuprofen may increase the risk for bone healing complications, not that it treats bone fractures." +17621968,Ibuprofen treats Cognitive impairment,1023,"Finally, anti-inflammatory drug ibuprofen ameliorated the peripheral surgical wounding-induced cognitive impairment in 18 month-old mice.",True,"Is the triple 'Ibuprofen treats Cognitive impairment' supported by the sentence: 'Finally, anti-inflammatory drug ibuprofen ameliorated the peripheral surgical wounding-induced cognitive impairment in 18 month-old mice.'?","Yes, the statement ""anti-inflammatory drug ibuprofen ameliorated the peripheral surgical wounding-induced cognitive impairment in 18 month-old mice"" does provide some level of support for the idea that ibuprofen can treat cognitive impairment, even if indirectly. This is because it suggests that ibuprofen can have a positive effect on cognitive function in mice with surgical wounding-induced cognitive impairment. However, it's important to note that this is in a specific model of cognitive impairment (induced by surgical wounding in mice), and it doesn't necessarily mean that ibuprofen would have the same effect in all cases of cognitive impairment in all species, including humans. Further research would be needed to confirm and extend these findings." +17292168,Ibuprofen treats Chronic pain,1024,"In the last several years, several topical NSAIDs including either diclofenac ibuprofen or salicylates for chronic pain have been approved in the United States while similar drugs have been available in Europe for years.",True,"Is the triple 'Ibuprofen treats Chronic pain' supported by the sentence: 'In the last several years, several topical NSAIDs including either diclofenac ibuprofen or salicylates for chronic pain have been approved in the United States while similar drugs have been available in Europe for years.'?","Yes, it is indirectly supported because it mentions ibuprofen as one of the approved drugs for chronic pain in the United States, implying its effectiveness in treating chronic pain." +15258520,Ibuprofen treats cardiovascular disorder,1025,Patent ductus arteriosus (PDA) is the most common cardiovascular abnormality of the preterm infant usually treated with ibuprofen (IBU).,False,Is the triple 'Ibuprofen treats cardiovascular disorder' supported by the sentence: 'Patent ductus arteriosus (PDA) is the most common cardiovascular abnormality of the preterm infant usually treated with ibuprofen (IBU).'?,"No, this statement does not provide direct or indirect support for the claim that ibuprofen treats cardiovascular disorders. The statement explains that patent ductus arteriosus (PDA) is a common cardiovascular abnormality in preterm infants, which is often treated with ibuprofen. However, it does not mention that ibuprofen has any therapeutic effect on other forms of cardiovascular disorders beyond PDA in preterm infants." +13826476,"Ibuprofen treats osteoarthritis, spine",1026,"In an open three-center pilot study, 17 patients suffering from chronic persistent pain syndrome, due to osteoarthritis of the hip and knee or spondylarthrosis, were treated orally with 1800-2400 mg Ibuprofen per day for 3 weeks.",True,"Is the triple 'Ibuprofen treats osteoarthritis, spine' supported by the sentence: 'In an open three-center pilot study, 17 patients suffering from chronic persistent pain syndrome, due to osteoarthritis of the hip and knee or spondylarthrosis, were treated orally with 1800-2400 mg Ibuprofen per day for 3 weeks.'?","Yes, it is indirectly supported because the study mentions that patients with chronic persistent pain syndrome due to osteoarthritis of the hip and knee were treated with Ibuprofen, implying that Ibuprofen can be used to treat osteoarthritis pain in these areas. However, it does not directly mention spondylarthrosis in the treatment group." +13722152,Ibuprofen treats Neck pain,1027,"The patient presented with a 6-month history of neck pain with radiation into the shoulder and arm on the left side, which was relieved by ibuprofen.",True,"Is the triple 'Ibuprofen treats Neck pain' supported by the sentence: 'The patient presented with a 6-month history of neck pain with radiation into the shoulder and arm on the left side, which was relieved by ibuprofen.'?","Yes, it is indirectly supported. The statement indicates that the patient's neck pain was relieved by ibuprofen, suggesting that ibuprofen can be an effective treatment for neck pain." +11790277,Ibuprofen treats hypertensive disorder,1028,"Treatment with nonselective anti-inflammatory drugs ibuprofen, indomethacin, or salicylic acid did not show any effect on angiotensin II-induced superoxide production, hypertension, or cardiac hypertrophy.",False,"Is the triple 'Ibuprofen treats hypertensive disorder' supported by the sentence: 'Treatment with nonselective anti-inflammatory drugs ibuprofen, indomethacin, or salicylic acid did not show any effect on angiotensin II-induced superoxide production, hypertension, or cardiac hypertrophy.'?","No, it is not directly or indirectly supported, as this statement suggests that ibuprofen, among other drugs, does not have an effect on angiotensin II-induced superoxide production, hypertension, or cardiac hypertrophy, implying that ibuprofen may not be an effective treatment for hypertension, which contradicts the initial statement." +11536369,Ibuprofen treats seasonal allergic rhinitis,1029,Addition of ibuprofen to pseudoephedrine and chlorpheniramine in the treatment of seasonal allergic rhinitis.,True,Is the triple 'Ibuprofen treats seasonal allergic rhinitis' supported by the sentence: 'Addition of ibuprofen to pseudoephedrine and chlorpheniramine in the treatment of seasonal allergic rhinitis.'?,"Yes, it is indirectly supported, as it mentions that Ibuprofen is used in a treatment for seasonal allergic rhinitis, but it does not explicitly state that Ibuprofen alone is effective for treating it." +11381904,Ibuprofen treats Premature birth,1030,This should be considered to assess pharmacokinetic-pharmacodynamic relationships of ibuprofen in premature neonates and subsequently to understand and refine the use of ibuprofen in managing PDA either as a prophylactic or curative treatment.,True,Is the triple 'Ibuprofen treats Premature birth' supported by the sentence: 'This should be considered to assess pharmacokinetic-pharmacodynamic relationships of ibuprofen in premature neonates and subsequently to understand and refine the use of ibuprofen in managing PDA either as a prophylactic or curative treatment.'?,"Yes, it is indirectly supported. The given sentence suggests that understanding and refining the use of ibuprofen in managing PDA (Patent Ductus Arteriosus, a condition often seen in premature neonates) involves studying its pharmacokinetic-pharmacodynamic relationships in these patients. This implies that studying ibuprofen's effects in premature neonates, including its potential role in treating premature birth, is a relevant area of research. However, it does not directly state that ibuprofen treats premature birth, but rather implies that it could play a role in managing a condition often associated with premature birth." +11239637,Ibuprofen treats Back pain,1031,"A 57-year-old woman believed that ibuprofen, prescribed for back pain, improved her idiopathic chronic cough that had been resistant to inhaled and oral corticosteroids.",True,"Is the triple 'Ibuprofen treats Back pain' supported by the sentence: 'A 57-year-old woman believed that ibuprofen, prescribed for back pain, improved her idiopathic chronic cough that had been resistant to inhaled and oral corticosteroids.'?","Yes, it is indirectly supported because it suggests a potential positive effect of Ibuprofen on a symptom (chronic cough) unrelated to its primary use (back pain), implying a broader range of therapeutic benefits." +10195210,Ibuprofen treats influenza,1032,"A multicenter, randomized, double-blind, double-dummy, placebo- and active-controlled, parallel-group comparison of diclofenac-K and ibuprofen for the treatment of adults with influenza-like symptoms.",False,"Is the triple 'Ibuprofen treats influenza' supported by the sentence: 'A multicenter, randomized, double-blind, double-dummy, placebo- and active-controlled, parallel-group comparison of diclofenac-K and ibuprofen for the treatment of adults with influenza-like symptoms.'?","No, this statement does not provide direct support for the claim that Ibuprofen treats influenza. The study mentioned compares diclofenac-K and ibuprofen for treating adults with influenza-like symptoms, but it does not confirm that ibuprofen is a treatment for influenza itself." +9950431,Ibuprofen treats rheumatic disorder,1033,"Eight preparations contained synthetic drugs (e.g. benzodiazepines and tricyclic antidepressants in sedative preparations, cyproheptadine in a remedy to gain bodyweight, ibuprofen and dipyrone in herbal capsules used to treat rheumatism).",True,"Is the triple 'Ibuprofen treats rheumatic disorder' supported by the sentence: 'Eight preparations contained synthetic drugs (e.g. benzodiazepines and tricyclic antidepressants in sedative preparations, cyproheptadine in a remedy to gain bodyweight, ibuprofen and dipyrone in herbal capsules used to treat rheumatism).'?","Yes, it is indirectly supported because it mentions ibuprofen being used in herbal capsules to treat rheumatism, which aligns with the statement that ibuprofen is used to treat rheumatic disorders." +9913360,Ibuprofen treats Myalgia,1034,Preliminary comparison of bromelain and Ibuprofen for delayed onset muscle soreness management.,True,Is the triple 'Ibuprofen treats Myalgia' supported by the sentence: 'Preliminary comparison of bromelain and Ibuprofen for delayed onset muscle soreness management.'?,"Yes, it is indirectly supported because both sentences discuss the use of Ibuprofen for muscle soreness, although the second one does not explicitly state that it treats Myalgia (muscle pain)." +9550056,Ibuprofen treats Acute Pain,1035,"BACKGROUND: Rofecoxib is a selective cyclooxygenase-2 inhibitor indicated for the treatment of acute pain, with similar analgesic efficacy to ibuprofen and naproxen sodium.",True,"Is the triple 'Ibuprofen treats Acute Pain' supported by the sentence: 'BACKGROUND: Rofecoxib is a selective cyclooxygenase-2 inhibitor indicated for the treatment of acute pain, with similar analgesic efficacy to ibuprofen and naproxen sodium.'?","Yes, it can be interpreted as indirect support. The statement mentions that Rofecoxib, similar to ibuprofen, is indicated for treating acute pain, implying that ibuprofen can also treat acute pain." +9536612,Ibuprofen treats Low back pain,1036,CONCLUSION: Continuous low-level heat wrap therapy was superior to both acetaminophen and ibuprofen for treating low back pain.,True,Is the triple 'Ibuprofen treats Low back pain' supported by the sentence: 'CONCLUSION: Continuous low-level heat wrap therapy was superior to both acetaminophen and ibuprofen for treating low back pain.'?,"Yes, it is indirectly supported because it mentions that ibuprofen is used for treating low back pain, but it does not specify whether it is superior to other treatments like continuous low-level heat wrap therapy." +9444914,Ibuprofen treats Arthralgia,1037,"To determine the effectiveness of oral glucosamine with ibuprofen for the relief of joint pain in osteoarthritis a mini-review (Griffiths, 2002) of double-blind randomized controlled trials comparing the two was undertaken.",False,"Is the triple 'Ibuprofen treats Arthralgia' supported by the sentence: 'To determine the effectiveness of oral glucosamine with ibuprofen for the relief of joint pain in osteoarthritis a mini-review (Griffiths, 2002) of double-blind randomized controlled trials comparing the two was undertaken.'?","No, it is not directly nor indirectly supported. The given statement is about a review on a study comparing the effectivness between oral glucosamine with ibuprofen in relieving joint pain in osteoarthritis, but it does not make any mention about ibuprofen being used for arthralgia (joint pain)." +9436288,Ibuprofen treats Alzheimer disease,1038,"In conclusion, NCX-2216 is more efficacious than ibuprofen or celecoxib in clearing Abeta deposits from the brains of Tg mice, implying potential benefit in the treatment of Alzheimer's dementia.",False,"Is the triple 'Ibuprofen treats Alzheimer disease' supported by the sentence: 'In conclusion, NCX-2216 is more efficacious than ibuprofen or celecoxib in clearing Abeta deposits from the brains of Tg mice, implying potential benefit in the treatment of Alzheimer's dementia.'?","No, this statement does not support that Ibuprofen treats Alzheimer's disease. In fact, it compares the efficacy of a different compound (NCX-2216) with Ibuprofen and Celecoxib in clearing Abeta deposits from the brains of Tg mice, which is a characteristic of Alzheimer's dementia. It does not indicate that Ibuprofen is a treatment for Alzheimer's disease." +9104501,Ibuprofen treats injury,1039,"Ibuprofen attenuates early lung injury in endotoxemic, neutropenic rats.",True,"Is the triple 'Ibuprofen treats injury' supported by the sentence: 'Ibuprofen attenuates early lung injury in endotoxemic, neutropenic rats.'?","Yes, it is indirectly supported, as both sentences suggest that Ibuprofen has a protective effect on some form of injury, one on a general level, the other more specific to lung injury in rats. However, for a direct correlation, more specific research would be needed to confirm that Ibuprofen has the same effect on human injuries outside of a laboratory setting." +8748381,Ibuprofen treats Dysmenorrhea,1040,CONCLUSION: Continuous low-level topical heat therapy was as effective as ibuprofen for the treatment of dysmenorrhea.,True,Is the triple 'Ibuprofen treats Dysmenorrhea' supported by the sentence: 'CONCLUSION: Continuous low-level topical heat therapy was as effective as ibuprofen for the treatment of dysmenorrhea.'?,"Yes, it is indirectly supported because both ibuprofen and continuous low-level topical heat therapy were found to be effective in treating dysmenorrhea, implying that ibuprofen can be used to treat this condition." +8698382,Ibuprofen treats Tension-type headache,1041,Is the combination of ibuprofen and caffeine effective for the treatment of a tension-type headache?,True,Is the triple 'Ibuprofen treats Tension-type headache' supported by the sentence: 'Is the combination of ibuprofen and caffeine effective for the treatment of a tension-type headache?'?,"Yes, it is indirectly supported because both statements refer to Ibuprofen being used for tension-type headaches, one specifically with caffeine, but it does not directly support the exact phrase ""Ibuprofen treats Tension-type headache""." +8452594,Ibuprofen treats migraine disorder,1042,"Evaluation of a novel solubilized formulation of ibuprofen in the treatment of migraine headache: a randomized, double-blind, placebo-controlled, dose-ranging study.",True,"Is the triple 'Ibuprofen treats migraine disorder' supported by the sentence: 'Evaluation of a novel solubilized formulation of ibuprofen in the treatment of migraine headache: a randomized, double-blind, placebo-controlled, dose-ranging study.'?","Yes, it is indirectly supported because it suggests that ibuprofen is effective in treating migraines, but it doesn't specifically mention that it's a 'triple' dose that is effective." +8420965,Ibuprofen treats Hemorrhage,1043,"A randomized trial measuring fecal blood loss after treatment with rofecoxib, ibuprofen, or placebo in healthy subjects.",False,"Is the triple 'Ibuprofen treats Hemorrhage' supported by the sentence: 'A randomized trial measuring fecal blood loss after treatment with rofecoxib, ibuprofen, or placebo in healthy subjects.'?","No, it is not directly nor indirectly supported, as this study does not involve hemorrhages, but rather measures fecal blood loss in healthy subjects treated with rofecoxib, ibuprofen, or placebo." +8397426,Ibuprofen treats rheumatoid arthritis,1044,Ibuprofen or aspirin in rheumatoid arthritis therapy.,True,Is the triple 'Ibuprofen treats rheumatoid arthritis' supported by the sentence: 'Ibuprofen or aspirin in rheumatoid arthritis therapy.'?,"Yes, it is indirectly supported. The given sentence suggests that both Ibuprofen and aspirin can be used in therapy for rheumatoid arthritis, implying that Ibuprofen is indeed a treatment for this condition." +7887942,Ibuprofen treats osteoarthritis,1045,"DESIGN: Ginger extract was compared to placebo and Ibuprofen in patients with osteoarthritis of the hip or knee in a controlled, double blind, double dummy, cross-over study with a wash-out period of one week followed by three treatment periods in a randomized sequence, each of three weeks duration.",True,"Is the triple 'Ibuprofen treats osteoarthritis' supported by the sentence: 'DESIGN: Ginger extract was compared to placebo and Ibuprofen in patients with osteoarthritis of the hip or knee in a controlled, double blind, double dummy, cross-over study with a wash-out period of one week followed by three treatment periods in a randomized sequence, each of three weeks duration.'?","Yes, it is indirectly supported because the study mentioned compares Ibuprofen to ginger extract in patients with osteoarthritis, implying that Ibuprofen is used as a treatment for this condition in a clinical setting. However, it does not directly support the statement that Ibuprofen specifically 'treats' osteoarthritis, as it does not discuss its mechanism of action or efficacy in detail." +7852264,Ibuprofen treats Headache,1046,"Besides oxygen, acetazolamide, dexamethasone and especially inhibitors of prostaglandin synthesis such as ibuprofen and naproxen are approved for the treatment of HAH.",True,"Is the triple 'Ibuprofen treats Headache' supported by the sentence: 'Besides oxygen, acetazolamide, dexamethasone and especially inhibitors of prostaglandin synthesis such as ibuprofen and naproxen are approved for the treatment of HAH.'?","Yes, it is indirectly supported because ibuprofen is mentioned as an inhibitor of prostaglandin synthesis that is approved for the treatment of headaches (HAH), which is a type of headache disorder. However, it's important to note that this statement doesn't explicitly say that ibuprofen treats all types of headaches, but it does support the general idea that ibuprofen can be used to treat certain headaches." +7851777,Ibuprofen treats patent ductus arteriosus,1047,OBJECTIVE: To evaluate the effect of intravenous ibuprofen and indomethacin for treatment of patent ductus arteriosus (PDA) on mesenteric and renal blood flow velocity in preterm infants.,True,Is the triple 'Ibuprofen treats patent ductus arteriosus' supported by the sentence: 'OBJECTIVE: To evaluate the effect of intravenous ibuprofen and indomethacin for treatment of patent ductus arteriosus (PDA) on mesenteric and renal blood flow velocity in preterm infants.'?,"Yes, it is indirectly supported, as it mentions ibuprofen being used for treatment of PDA, which is a condition that affects premature infants, but it does not specifically mention that ibuprofen treats PDA, but rather that it's used for treatment of it, which is a common practice in neonatology to prevent further complications of PDA in preterm infants, it's not a cure for PDA, it's a treatment for it, to prevent further complications, so in a broader sense, it's correct to say that ibuprofen is used to treat PDA, but it's not a direct statement from this specific abstract, it's a general knowledge in neonatology field, but it's not a direct evidence from this specific abstract, but it's still related to ibuprofen being used for PDA treatment in preterm infants, so it's an indirect support of that statement, but it's not a direct evidence from this abstract." +7732956,Ibuprofen treats Pain,1048,"The WOMAC detected significant differences between ibuprofen and placebo for pain and physical functioning, whereas the SF-36 detected differences for the bodily pain subscale.",True,"Is the triple 'Ibuprofen treats Pain' supported by the sentence: 'The WOMAC detected significant differences between ibuprofen and placebo for pain and physical functioning, whereas the SF-36 detected differences for the bodily pain subscale.'?","Yes, it is indirectly supported. The given sentences suggest that Ibuprofen has a significant effect on pain and physical functioning compared to placebo (according to the WOMAC scale), and it also has an impact on bodily pain (according to the SF-36 scale). Therefore, it can be inferred that Ibuprofen does treat pain, which aligns with the statement ""Ibuprofen treats Pain"". However, please note that this is an interpretation based on the provided information, and for a more accurate conclusion, a direct study on Ibuprofen's effect on pain would be required." +7686895,Ibuprofen treats arthritic joint disease,1049,"I take ibuprofen regularly for my arthritis, but I've heard that it may lead to kidney damage.",True,"Is the triple 'Ibuprofen treats arthritic joint disease' supported by the sentence: 'I take ibuprofen regularly for my arthritis, but I've heard that it may lead to kidney damage.'?","Yes, it is indirectly supported. The user's statement suggests that they take ibuprofen regularly for their arthritis, which aligns with the first part of the statement (""Ibuprofen treats arthritic joint disease""). The second part of the statement (""but I've heard that it may lead to kidney damage"") implies potential risks or side effects associated with long-term use of ibuprofen, which could be relevant to people with certain health conditions, such as kidney disease. However, this does not directly support the statement about treating arthritis, but rather highlights a potential risk associated with its use." +7258310,Ibuprofen treats Fever,1050,Paracetamol or ibuprofen in febrile children.,True,Is the triple 'Ibuprofen treats Fever' supported by the sentence: 'Paracetamol or ibuprofen in febrile children.'?,"Yes, it is indirectly supported. The given sentence suggests that either Paracetamol or Ibuprofen can be used to treat fever in children, implying that Ibuprofen is indeed a treatment for fever." +7210912,Ibuprofen treats Toothache,1051,"A double-blind, parallel-group study compared the analgesic efficacy of rofecoxib to placebo and ibuprofen in 102 patients with dental pain.",True,"Is the triple 'Ibuprofen treats Toothache' supported by the sentence: 'A double-blind, parallel-group study compared the analgesic efficacy of rofecoxib to placebo and ibuprofen in 102 patients with dental pain.'?","Yes, it is indirectly supported because both sentences discuss the pain relieving properties of ibuprofen in a dental context, but they do not directly state that ibuprofen treats toothaches." +25984950,Cefmenoxime treats bacterial infectious disease,1052,Cefmenoxime versus cefoxitin in the treatment of serious bacterial infections.,True,Is the triple 'Cefmenoxime treats bacterial infectious disease' supported by the sentence: 'Cefmenoxime versus cefoxitin in the treatment of serious bacterial infections.'?,"Yes, it is indirectly supported because both sentences discuss Cefmenoxime being used to treat bacterial infections, but the second one does not explicitly state that Cefmenoxime is used to treat the infections, rather it compares it with another antibiotic, Cefoxitin, in treating serious bacterial infections." +21500374,Ivabradine treats hypotensive disorder,1053,"These are: the association of dobutamine infusion with amiodarone or ivabradine in patients with symptomatic hypotension, and high-dose furosemide associated to hypertonic saline solution, levosimendan, hydralazine/isosorbide dinitrate, sodium nitroprusside or ivabradine in hemodynamically stable patients.",True,"Is the triple 'Ivabradine treats hypotensive disorder' supported by the sentence: 'These are: the association of dobutamine infusion with amiodarone or ivabradine in patients with symptomatic hypotension, and high-dose furosemide associated to hypertonic saline solution, levosimendan, hydralazine/isosorbide dinitrate, sodium nitroprusside or ivabradine in hemodynamically stable patients.'?","Yes, the statement does provide indirect support for the idea that Ivabradine can be used to treat hypotensive disorder, as it is listed as an option in treating symptomatic hypotension when used with dobutamine infusion, according to your provided text." +18841652,Ivabradine treats toxic shock syndrome,1054,If Channel Inhibition With Ivabradine Does Not Improve Cardiac and Vascular Function in Experimental Septic Shock.,False,Is the triple 'Ivabradine treats toxic shock syndrome' supported by the sentence: 'If Channel Inhibition With Ivabradine Does Not Improve Cardiac and Vascular Function in Experimental Septic Shock.'?,"No, it is not directly or indirectly supported because toxic shock syndrome is not mentioned in the given sentence, which refers to cardiac and vascular function in experimental septic shock, not in toxic shock syndrome." +18126606,Ivabradine treats mitral valve stenosis,1055,Ivabradine thus can be used effectively and safely in patients with MS in normal sinus rhythm who are intolerant or contraindicated for beta-blocker therapy.,False,Is the triple 'Ivabradine treats mitral valve stenosis' supported by the sentence: 'Ivabradine thus can be used effectively and safely in patients with MS in normal sinus rhythm who are intolerant or contraindicated for beta-blocker therapy.'?,"No, it is not directly or indirectly supported by that statement, as Ivabradine's effectiveness is mentioned in relation to patients with Mitral Stenosis (MS) in normal sinus rhythm who cannot tolerate or are contraindicated for beta-blocker therapy, but there is no mention of Ivabradine treating Mitral Valve Stenosis itself in that statement." +17604342,Ivabradine treats atrial fibrillation,1056,Ivabradine is ineffective in atrial fibrillation.,False,Is the triple 'Ivabradine treats atrial fibrillation' supported by the sentence: 'Ivabradine is ineffective in atrial fibrillation.'?,"No, it's not. The statement ""Ivabradine is ineffective in atrial fibrillation"" suggests that Ivabradine does not have a positive effect on treating atrial fibrillation, which contradicts the claim that it does treat atrial fibrillation, even indirectly." +17604340,Ivabradine treats diastolic heart failure,1057,The aim of the study was to compare the therapeutic effects of ivabradine in diastolic heart failure with preserved left ventricular systolic function.,True,Is the triple 'Ivabradine treats diastolic heart failure' supported by the sentence: 'The aim of the study was to compare the therapeutic effects of ivabradine in diastolic heart failure with preserved left ventricular systolic function.'?,"Yes, it is indirectly supported because the statement mentions that ivabradine is used in a study on diastolic heart failure with preserved left ventricular systolic function, implying a potential therapeutic effect in this condition." +15681673,Ivabradine treats multiple organ dysfunction syndrome,1058,CONCLUSIONS: The MODI (f)Y trial is the first application of ivabradine as a pure heart rate reducing agent in MODS patients.,True,Is the triple 'Ivabradine treats multiple organ dysfunction syndrome' supported by the sentence: 'CONCLUSIONS: The MODI (f)Y trial is the first application of ivabradine as a pure heart rate reducing agent in MODS patients.'?,"Yes, it is indirectly supported. The sentence mentions that ivabradine was used as a heart rate reducing agent in patients with Multiple Organ Dysfunction Syndrome (MODS), which aligns with the statement that ivabradine treats Multiple Organ Dysfunction Syndrome, although it doesn't directly state that ivabradine is a treatment for this condition." +15641743,Ivabradine treats systolic heart failure,1059,Ivabradine added to guidelines-based therapy in systolic heart failure patients.,True,Is the triple 'Ivabradine treats systolic heart failure' supported by the sentence: 'Ivabradine added to guidelines-based therapy in systolic heart failure patients.'?,"Yes, it is indirectly supported because it suggests that ivabradine is used in addition to standard therapy for systolic heart failure patients, implying that it has a role in treating this condition. However, it does not directly state that ivabradine treats systolic heart failure on its own." +13559450,Ivabradine treats Tachycardia,1060,"Clinical studies proved the efficacy of ivabradine in patients with stable angina, while clinical data are awaited to verify its probable value in the treatment of atrial tachyarrhythmias and tachycardia due to ventricular dysfunction.",True,"Is the triple 'Ivabradine treats Tachycardia' supported by the sentence: 'Clinical studies proved the efficacy of ivabradine in patients with stable angina, while clinical data are awaited to verify its probable value in the treatment of atrial tachyarrhythmias and tachycardia due to ventricular dysfunction.'?","Yes, it is indirectly supported. The sentence mentions that clinical data is awaited to verify ivabradine's value in treating atrial tachyarrhythmias and tachycardia due to ventricular dysfunction, implying that there is potential for ivabradine to treat tachycardia, even though it has not been proven yet in clinical studies." +12424888,Ivabradine treats coronary artery disorder,1061,"The effective drug, ivabradine, has demonstrated anti-anginal, anti-ischemic efficacy and now is being tested for its effect on survival in patients with coronary artery disease and impaired left ventricular function, as well as for heart failure.",True,"Is the triple 'Ivabradine treats coronary artery disorder' supported by the sentence: 'The effective drug, ivabradine, has demonstrated anti-anginal, anti-ischemic efficacy and now is being tested for its effect on survival in patients with coronary artery disease and impaired left ventricular function, as well as for heart failure.'?","Yes, it is indirectly supported. The statement mentions that Ivabradine has demonstrated anti-anginal and anti-ischemic efficacy in patients with coronary artery disease, which implies it could potentially treat disorders related to this condition." +12164130,Ivabradine treats Stable angina,1062,New agent ivabradine (Procoralan) for treatment of chronic stable angina.,True,Is the triple 'Ivabradine treats Stable angina' supported by the sentence: 'New agent ivabradine (Procoralan) for treatment of chronic stable angina.'?,"Yes, it is indirectly supported. The mention of Ivabradine as a new agent for treating chronic stable angina implies that it has a role in managing this condition, which includes treating stable angina." +11342280,Ivabradine treats cardiovascular disorder,1063,Heart rate lowering by specific and selective I(f) current inhibition with ivabradine: a new therapeutic perspective in cardiovascular disease.,True,Is the triple 'Ivabradine treats cardiovascular disorder' supported by the sentence: 'Heart rate lowering by specific and selective I(f) current inhibition with ivabradine: a new therapeutic perspective in cardiovascular disease.'?,"Yes, it is indirectly supported because ivabradine specifically inhibits I(f) current, which can lead to heart rate reduction, thereby potentially treating cardiovascular disorders as suggested in the given statement." +26843374,Cefixime treats tonsillitis,1064,These results show that cefixime once daily is at least as effective as penicillin V t.i.d. in pharyngitis and tonsillitis in children.,True,Is the triple 'Cefixime treats tonsillitis' supported by the sentence: 'These results show that cefixime once daily is at least as effective as penicillin V t.i.d. in pharyngitis and tonsillitis in children.'?,"Yes, it can be inferred as supported, as the study indicates Cefixime's effectiveness in treating pharyngitis and tonsillitis in children, which includes tonsillitis as a subtype of pharyngitis." +23970374,Cefixime treats Infection,1065,The aim of this study is to evaluate cefixime for the treatment of osteoarticular infections in pediatric SCD patients by retrospective design.,True,Is the triple 'Cefixime treats Infection' supported by the sentence: 'The aim of this study is to evaluate cefixime for the treatment of osteoarticular infections in pediatric SCD patients by retrospective design.'?,"Yes, it could be interpreted as indirect support, as Cefixime is being evaluated for treating infections in a specific patient group, implying its potential therapeutic role in infections. However, it's important to note that direct causality cannot be inferred from a retrospective study design alone." +22544340,Cefixime treats pharyngitis,1066,Purpose: To report a case of Acute bilateral angle closure and Myopia following oral Cefixime therapy for pharyngitis.,True,Is the triple 'Cefixime treats pharyngitis' supported by the sentence: 'Purpose: To report a case of Acute bilateral angle closure and Myopia following oral Cefixime therapy for pharyngitis.'?,"Yes, it is indirectly supported because the sentence mentions that Cefixime was used for treating pharyngitis, which aligns with the first part of the statement, and it also reports an adverse effect related to Cefixime therapy, which implies that Cefixime does have an impact on the human body, supporting the idea that it can treat diseases like pharyngitis. However, it does not directly prove that Cefixime treats pharyngitis because it does not mention the effectiveness of Cefixime in treating pharyngitis, but rather just mentions its usage for that purpose." +22138225,Cefixime treats syphilis,1067,DISCUSSION: Demonstration of efficacy of cefixime in the treatment of active syphilis in this Phase 2 trial among non-pregnant women will inform a proposed randomized controlled trial to evaluate cefixime as an alternative treatment for pregnant women with active syphilis to evaluate prevention of congenital syphilis.,True,Is the triple 'Cefixime treats syphilis' supported by the sentence: 'DISCUSSION: Demonstration of efficacy of cefixime in the treatment of active syphilis in this Phase 2 trial among non-pregnant women will inform a proposed randomized controlled trial to evaluate cefixime as an alternative treatment for pregnant women with active syphilis to evaluate prevention of congenital syphilis.'?,"Yes, it is indirectly supported because it mentions that cefixime has demonstrated efficacy in treating active syphilis in a trial, which suggests that it could potentially be used as a treatment for syphilis, including in pregnant women to prevent congenital syphilis. However, it does not directly state that cefixime treats syphilis, but rather implies it through discussing its demonstrated efficacy in treatment." +20619094,Cefixime treats bronchitis,1068,"Two weeks following her return to France, the patient presented with an episode of bronchitis and received 5 days of treatment with cefixime (a third-generation cephalosporin).",True,"Is the triple 'Cefixime treats bronchitis' supported by the sentence: 'Two weeks following her return to France, the patient presented with an episode of bronchitis and received 5 days of treatment with cefixime (a third-generation cephalosporin).'?","Yes, it is indirectly supported because it mentions that a patient was treated for an episode of bronchitis with Cefixime. However, it doesn't directly state that Cefixime treats bronchitis." +12941415,Cefixime treats otitis media,1069,Efficacy and tolerability of cefixime in otitis media.,True,Is the triple 'Cefixime treats otitis media' supported by the sentence: 'Efficacy and tolerability of cefixime in otitis media.'?,"Yes, it is indirectly supported. The given statement suggests that Cefixime has been studied for its efficacy (effectiveness) and tolerability (how well it can be taken) in treating otitis media (middle ear infection). This implies that Cefixime is a potential treatment option for this condition, which aligns with the claim that it 'treats' otitis media. However, it's important to note that this is an indirect support, as the original statement does not directly confirm that Cefixime is used to treat otitis media, but rather that it has been studied in this context." +8827692,Cefixime treats gonorrhea,1070,A randomized trial of ciprofloxacin versus cefixime for treatment of gonorrhea after rapid emergence of gonococcal ciprofloxacin resistance in The Philippines.,True,Is the triple 'Cefixime treats gonorrhea' supported by the sentence: 'A randomized trial of ciprofloxacin versus cefixime for treatment of gonorrhea after rapid emergence of gonococcal ciprofloxacin resistance in The Philippines.'?,"Yes, it is indirectly supported because it mentions that Cefixime is used for treating Gonorrhea in a clinical study, implying its effectiveness against Gonorrhea, but it does not directly mention that Cefixime 'treats' Gonorrhea as a definitive statement." +7594422,Cefixime treats bacterial infectious disease,1071,A randomized controlled clinical study of cefetamet pivoxil (CAT) compared with cefixime (CFX) was conducted to evaluate its safety and efficacy in treating bacterial infections.,True,Is the triple 'Cefixime treats bacterial infectious disease' supported by the sentence: 'A randomized controlled clinical study of cefetamet pivoxil (CAT) compared with cefixime (CFX) was conducted to evaluate its safety and efficacy in treating bacterial infections.'?,"Yes, it is indirectly supported because both Cefixime (CFX) and Cefetamet Pivoxil (CAT) are antibiotics used to treat bacterial infections, as mentioned in the provided sentence. However, it does not directly state that Cefixime (CFX) specifically treats bacterial infections, but it is implied through the context." +26078551,Ceftizoxime treats bacterial infectious disease,1072,"Eighteen children with the following bacterial infections were treated with ceftizoxime; respiratory tract infection (13), acute otitis media (1), acute intervertebral chondritis and tonsillitis (1), chronic cystitis (1), subcutaneous abscess (1) and chronic bacteremia (1).",True,"Is the triple 'Ceftizoxime treats bacterial infectious disease' supported by the sentence: 'Eighteen children with the following bacterial infections were treated with ceftizoxime; respiratory tract infection (13), acute otitis media (1), acute intervertebral chondritis and tonsillitis (1), chronic cystitis (1), subcutaneous abscess (1) and chronic bacteremia (1).'?","Yes, the statement is indirectly supported because it mentions that 18 children were treated with Ceftizoxime for various types of bacterial infections, implying that Ceftizoxime is used to treat bacterial infections, but it doesn't explicitly state that it is a treatment for all types of bacterial infections." +25661332,Ceftizoxime treats osteomyelitis,1073,"Experience with imipenem/cilastatin and that reported for cefotaxime, ceftazidime, and ceftizoxime in the treatment of biopsy-proved osteomyelitis was compared, using data from published reports from five centers.",True,"Is the triple 'Ceftizoxime treats osteomyelitis' supported by the sentence: 'Experience with imipenem/cilastatin and that reported for cefotaxime, ceftazidime, and ceftizoxime in the treatment of biopsy-proved osteomyelitis was compared, using data from published reports from five centers.'?","Yes, it is indirectly supported as it mentions Ceftizoxime being used in the treatment of biopsy-proven osteomyelitis, similar to how it is mentioned in your statement, although it doesn't explicitly state that Ceftizoxime is used to treat osteomyelitis on its own." +23911647,Trimetazidine treats diabetic kidney disease,1074,"In DIN and diabetic kidney diseases,TMZ treatment prevents renal injury by inactivating immune cells, attenuating renal fibrosis, inflammation, apoptosis, and histological abnormalities.",True,"Is the triple 'Trimetazidine treats diabetic kidney disease' supported by the sentence: 'In DIN and diabetic kidney diseases,TMZ treatment prevents renal injury by inactivating immune cells, attenuating renal fibrosis, inflammation, apoptosis, and histological abnormalities.'?","Yes, it is indirectly supported because Trimetazidine (TMZ) is shown to prevent renal injury in diabetes-induced nephropathy (DIN) through various mechanisms, which could potentially benefit patients with diabetic kidney disease (diabetic nephropathy). However, it does not explicitly state that Trimetazidine directly treats diabetic kidney disease, but it does suggest a possible therapeutic role in managing complications associated with it." +17755056,Trimetazidine treats Cardiotoxicity,1075,Concomitant administration of trimetazidine attenuates significantly the cardiotoxicity and hepatotoxity induced by doxorubicin.,True,Is the triple 'Trimetazidine treats Cardiotoxicity' supported by the sentence: 'Concomitant administration of trimetazidine attenuates significantly the cardiotoxicity and hepatotoxity induced by doxorubicin.'?,"Yes, it is indirectly supported because both statements discuss Trimetazidine's role in reducing cardiotoxicity, although in different contexts (one is specific to doxorubicin)." +17682787,Trimetazidine treats cardiovascular disorder,1076,Defining the role of trimetazidine in the treatment of cardiovascular disorders: some insights on its role in heart failure and peripheral artery disease.,True,Is the triple 'Trimetazidine treats cardiovascular disorder' supported by the sentence: 'Defining the role of trimetazidine in the treatment of cardiovascular disorders: some insights on its role in heart failure and peripheral artery disease.'?,"Yes, the statement ""Trimetazidine treats cardiovascular disorders"" is indirectly supported by the given sentence. This is because the sentence discusses the role of Trimetazidine in treating heart failure and peripheral artery disease, both of which are types of cardiovascular disorders. However, it's important to note that this doesn't necessarily mean that Trimetazidine is a definitive treatment for all cardiovascular disorders, but rather that it has a demonstrated role in managing certain specific conditions within this broader category." +19370408,Cefodizime treats bacterial infectious disease,1077,[Clinical experience with cefodizime in bacterial infection of children].,True,Is the triple 'Cefodizime treats bacterial infectious disease' supported by the sentence: '[Clinical experience with cefodizime in bacterial infection of children].'?,"Yes, it is indirectly supported, as clinical experience with a drug in a specific context, such as bacterial infections in children, suggests that it has some efficacy in treating such conditions, which aligns with the statement that Cefodizime treats bacterial infectious diseases. However, it's important to note that this is an inference based on a general understanding of antibiotics and their use, rather than a direct statement from the provided text." +9968932,Acadesine treats B-cell chronic lymphocytic leukemia,1078,These results suggest a new pathway involving AMPK in the control of apoptosis in B-CLL cells and raise the possibility of using acadesine in B-CLL treatment.,True,Is the triple 'Acadesine treats B-cell chronic lymphocytic leukemia' supported by the sentence: 'These results suggest a new pathway involving AMPK in the control of apoptosis in B-CLL cells and raise the possibility of using acadesine in B-CLL treatment.'?,"Yes, the statement does provide some support for that idea, as it suggests that acadesine (AICAR) may have a role in controlling apoptosis in B-CLL cells, possibly through an AMPK pathway, implying a potential therapeutic application for treating B-cell chronic lymphocytic leukemia (B-CLL). However, further research would be necessary to establish a more direct link between acadesine treatment and B-CLL, as this statement is based on experimental findings in cells, not a clinical trial in patients with B-CLL." +24441273,Ranolazine treats amyotrophic lateral sclerosis,1079,DISCUSSION: Ranolazine was well tolerated in ALS up to 2000 mg daily with gastrointestinal side effects being the most frequent.,False,Is the triple 'Ranolazine treats amyotrophic lateral sclerosis' supported by the sentence: 'DISCUSSION: Ranolazine was well tolerated in ALS up to 2000 mg daily with gastrointestinal side effects being the most frequent.'?,"No, it does not support that Ranolazine treats amyotrophic lateral sclerosis (ALS). The sentence only states that Ranolazine was well tolerated in ALS patients up to a certain dosage, with gastrointestinal side effects being the most frequent." +16822044,Ranolazine treats type 2 diabetes mellitus,1080,Evaluation of ranolazine in patients with type 2 diabetes mellitus and chronic stable angina: results from the TERISA randomized clinical trial (Type 2 Diabetes Evaluation of Ranolazine in Subjects With Chronic Stable Angina).,True,Is the triple 'Ranolazine treats type 2 diabetes mellitus' supported by the sentence: 'Evaluation of ranolazine in patients with type 2 diabetes mellitus and chronic stable angina: results from the TERISA randomized clinical trial (Type 2 Diabetes Evaluation of Ranolazine in Subjects With Chronic Stable Angina).'?,"Yes, the statement is indirectly supported because it mentions that an evaluation of Ranolazine was conducted on patients with both Type 2 Diabetes Mellitus and chronic stable angina, indicating a potential connection between Ranolazine treatment and Type 2 Diabetes Mellitus management, even though it does not explicitly state that Ranolazine 'treats' Type 2 Diabetes Mellitus." +15243162,Ranolazine treats diastolic heart failure,1081,"Moreover, ranolazine holds potential promise to be effective in treatment of atrial fibrillation and diastolic heart failure.",True,"Is the triple 'Ranolazine treats diastolic heart failure' supported by the sentence: 'Moreover, ranolazine holds potential promise to be effective in treatment of atrial fibrillation and diastolic heart failure.'?","Yes, it is indirectly supported as the sentence mentions that Ranolazine has potential in treating both atrial fibrillation and diastolic heart failure." +14672486,Ranolazine treats long QT syndrome,1082,"Small clinical trials suggest that ranolazine may have a role in the treatment of patients with non-ST-elevation acute coronary syndrome, atrial fibrillation, long QT syndromes, and sinus node dysfunction.",True,"Is the triple 'Ranolazine treats long QT syndrome' supported by the sentence: 'Small clinical trials suggest that ranolazine may have a role in the treatment of patients with non-ST-elevation acute coronary syndrome, atrial fibrillation, long QT syndromes, and sinus node dysfunction.'?","Yes, the statement does provide some level of support for the idea that 'ranolazine treats long QT syndrome'. It mentions 'long QT syndromes' in the context of conditions that small clinical trials suggest may be treated with ranolazine. However, it's important to note that this does not confirm a direct treatment relationship, as further research and more definitive evidence would be needed to establish such a claim." +13891593,Ranolazine treats atrial fibrillation,1083,"Recent studies have increased interest in fast-unbinding Na(+) channel blockers like vernakalant (RSD1235) and ranolazine for AF therapy, but the mechanism of efficacy is poorly understood.",True,"Is the triple 'Ranolazine treats atrial fibrillation' supported by the sentence: 'Recent studies have increased interest in fast-unbinding Na(+) channel blockers like vernakalant (RSD1235) and ranolazine for AF therapy, but the mechanism of efficacy is poorly understood.'?","Yes, it is indirectly supported because it mentions that ranolazine, a Na+(+) channel blocker, is being considered for AF (atrial fibrillation) therapy, indicating that it has some potential therapeutic effect, even though the mechanism of efficacy is not fully understood." +12975239,Ranolazine treats coronary artery disorder,1084,Ranolazine for the management of coronary artery disease.,True,Is the triple 'Ranolazine treats coronary artery disorder' supported by the sentence: 'Ranolazine for the management of coronary artery disease.'?,"Yes, it is indirectly supported because both sentences discuss Ranolazine's role in managing a type of heart disease, specifically coronary artery disease, which is a type of coronary artery disorder. However, it's important to note that the first statement mentions ""treats"", while the second statement mentions ""management"". These two terms can have slightly different connotations, but they both imply a therapeutic role for Ranolazine in relation to heart disease." +10629663,Ranolazine treats Angina pectoris,1085,"Effects of a new metabolic modulator, ranolazine, on exercise tolerance in angina pectoris patients treated with beta-blocker or diltiazem.",True,"Is the triple 'Ranolazine treats Angina pectoris' supported by the sentence: 'Effects of a new metabolic modulator, ranolazine, on exercise tolerance in angina pectoris patients treated with beta-blocker or diltiazem.'?",Yes +9302562,Ranolazine treats myocardial ischemia,1086,Ranolazine has been shown to improve exercise-induced myocardial ischaemia and to lessen the severity of angina in the setting of chronic ischaemic heart disease.,True,Is the triple 'Ranolazine treats myocardial ischemia' supported by the sentence: 'Ranolazine has been shown to improve exercise-induced myocardial ischaemia and to lessen the severity of angina in the setting of chronic ischaemic heart disease.'?,"Yes, this statement does support, at least indirectly, that Ranolazine treats myocardial ischemia. It mentions that Ranolazine improves exercise-induced myocardial ischaemia, which implies that it has a therapeutic effect on the condition, thus treating it in a way." +9302560,Ranolazine treats cardiovascular disorder,1087,Ranolazine is a novel drug that has shown promise in the treatment of cardiovascular disease.,True,Is the triple 'Ranolazine treats cardiovascular disorder' supported by the sentence: 'Ranolazine is a novel drug that has shown promise in the treatment of cardiovascular disease.'?,"Yes, it can be inferred as indirect support because Ranolazine being promising in treating cardiovascular disease suggests it could potentially treat cardiovascular disorders, which fall under this broader category of disease." +27475554,Prednisolone treats microscopic polyangiitis,1088,Microscopic polyarteritis nodosa was diagnosed and therapy with prednisolone was begun.,True,Is the triple 'Prednisolone treats microscopic polyangiitis' supported by the sentence: 'Microscopic polyarteritis nodosa was diagnosed and therapy with prednisolone was begun.'?,"Yes, it is indirectly supported, as prednisolone is being used as a therapy for Microscopic Polyarteritis Nodosa, which is a type of Microscopic Polyangiitis." +26307899,Prednisolone treats eye disorder,1089,A short trial with high doses of prednisolone to treat a 62 year-old woman with malignant ophthalmopathy due to Graves disease yielded an unsatisfactory improvement after 5-6 days.,False,Is the triple 'Prednisolone treats eye disorder' supported by the sentence: 'A short trial with high doses of prednisolone to treat a 62 year-old woman with malignant ophthalmopathy due to Graves disease yielded an unsatisfactory improvement after 5-6 days.'?,"No, it is not directly supported because the given sentence mentions an unsatisfactory improvement after a short trial, while the statement implies that Prednisolone can treat an eye disorder related to Graves disease, which is not stated in your provided evidence." +25942811,Prednisolone treats sympathetic ophthalmia,1090,"[""Abolishment"" syndrome in prednisolone treatment of patients with sympathetic ophthalmia].",True,"Is the triple 'Prednisolone treats sympathetic ophthalmia' supported by the sentence: '[""Abolishment"" syndrome in prednisolone treatment of patients with sympathetic ophthalmia].'?","Yes, it is indirectly supported, as both statements suggest that Prednisolone is used to treat sympathetic ophthalmia, but they do not directly state that it 'treats' it, rather that it can potentially 'abolish' a certain syndrome associated with it." +24297743,Prednisolone treats exfoliative dermatitis,1091,"A 60-year-old Aboriginal man with underlying severe exfoliative dermatitis, treated with oral azathioprine and oral prednisolone, presented with left painful red eye for ten days.",True,"Is the triple 'Prednisolone treats exfoliative dermatitis' supported by the sentence: 'A 60-year-old Aboriginal man with underlying severe exfoliative dermatitis, treated with oral azathioprine and oral prednisolone, presented with left painful red eye for ten days.'?","Yes, it is indirectly supported. The statement mentions that a patient with severe exfoliative dermatitis was treated with oral prednisolone, implying that prednisolone is used to treat this condition." +24291326,Prednisolone treats Anti-neutrophil cytoplasmic antibody-associated vasculitis,1092,"These findings were consistent with a diagnosis of ANCA-associated vasculitis, and treatment with prednisolone markedly improved her condition.",True,"Is the triple 'Prednisolone treats Anti-neutrophil cytoplasmic antibody-associated vasculitis' supported by the sentence: 'These findings were consistent with a diagnosis of ANCA-associated vasculitis, and treatment with prednisolone markedly improved her condition.'?","Yes, it is. The sentence suggests that a patient with ANCA-associated vasculitis was treated with prednisolone and that their condition improved. This implies that prednisolone is used to treat ANCA-associated vasculitis, which is what the triple statement suggests." +24042094,Prednisolone treats biliary atresia,1093,"In 2010, a study on the advantages of budesonide compared to prednisolone in autoimmune hepatitis gave rise to experimental therapy using budesonide as an adjuvant BA treatment.",False,"Is the triple 'Prednisolone treats biliary atresia' supported by the sentence: 'In 2010, a study on the advantages of budesonide compared to prednisolone in autoimmune hepatitis gave rise to experimental therapy using budesonide as an adjuvant BA treatment.'?","No. This statement does not directly support that prednisolone treats biliary atresia (BA). Instead, it compares budesonide to prednisolone in autoimmune hepatitis treatments. It does not mention prednisolone as a treatment for BA." +23981131,Prednisolone treats mycosis fungoides,1094,Prednisolone was initially used alone as an alternative treatment for CEL.,False,Is the triple 'Prednisolone treats mycosis fungoides' supported by the sentence: 'Prednisolone was initially used alone as an alternative treatment for CEL.'?,"No, it is not directly or indirectly supported. The reason is that CEL (Chronic Eosinophilic Leukemia) is a type of blood cancer, while Mycosis Fungoides is a type of skin lymphoma, which is a completely different medical condition from CEL. The two diseases have different causes, symptoms, and treatments, so a treatment that works for one does not necessarily work for the other." +23374627,Prednisolone treats trichinellosis,1095,"This study assessed the antiparasitic and anti-inflammatory effects of Citrus limon and Capsicum frutescens on murine trichinellosis and compared them with those of albendazole and prednisolone, which are conventionally used to treat trichinellosis.",True,"Is the triple 'Prednisolone treats trichinellosis' supported by the sentence: 'This study assessed the antiparasitic and anti-inflammatory effects of Citrus limon and Capsicum frutescens on murine trichinellosis and compared them with those of albendazole and prednisolone, which are conventionally used to treat trichinellosis.'?","Yes, it is indirectly supported because prednisolone is mentioned as one of the conventionally used treatments for trichinellosis in this study, even though it does not directly state that prednisolone is used to treat trichinellosis specifically because of its anti-inflammatory effects." +22580782,Prednisolone treats interstitial lung disease 2,1096,Regression of Lung Squamous Cell Carcinoma after the Withdrawal of Cyclosporin A Combined With Pirfenidone Treatment in a Patient with Idiopathic Pulmonary Fibrosis.A 72-year-old man was treated with prednisolone and cyclosporine A for idiopathic pulmonary fibrosis.,False,Is the triple 'Prednisolone treats interstitial lung disease 2' supported by the sentence: 'Regression of Lung Squamous Cell Carcinoma after the Withdrawal of Cyclosporin A Combined With Pirfenidone Treatment in a Patient with Idiopathic Pulmonary Fibrosis.A 72-year-old man was treated with prednisolone and cyclosporine A for idiopathic pulmonary fibrosis.'?,"No, it is not directly or indirectly supported, as this statement discusses a patient with idiopathic pulmonary fibrosis being treated with prednisolone and cyclosporine A, but it does not mention anything about interstitial lung disease, Prednisolone's effect on it, nor does it mention Pirfenidone treating it either." +22500116,Prednisolone treats HIV infectious disease,1097,"The most common coexisting conditions were HIV infection (30%), prednisolone therapy (16.9%), and diabetes mellitus (15.7%).",False,"Is the triple 'Prednisolone treats HIV infectious disease' supported by the sentence: 'The most common coexisting conditions were HIV infection (30%), prednisolone therapy (16.9%), and diabetes mellitus (15.7%).'?","No, it is not directly or indirectly supported. The given sentence mentions that HIV infection, prednisolone therapy, and diabetes mellitus coexist, but it does not imply that prednisolone is a treatment for HIV in any way." +22130331,Prednisolone treats schizophrenia,1098,"Therefore, the effect of prednisolone can be studied as a proof of concept for immune modulation as a treatment for schizophrenia.",True,"Is the triple 'Prednisolone treats schizophrenia' supported by the sentence: 'Therefore, the effect of prednisolone can be studied as a proof of concept for immune modulation as a treatment for schizophrenia.'?","Yes, it is indirectly supported because both statements suggest a connection between Prednisolone and treatment for schizophrenia from an immunological perspective. However, it's important to note that Prednisolone is primarily a corticosteroid used to reduce inflammation, not a treatment for schizophrenia. The sentence you provided is a speculative statement about studying its effects in relation to immune modulation as a potential treatment for schizophrenia." +21634207,Prednisolone treats chronic primary adrenal insufficiency,1099,The patient started insulin therapy and treatment for AD with prednisolone and fludrocortisone with good clinical response.,True,Is the triple 'Prednisolone treats chronic primary adrenal insufficiency' supported by the sentence: 'The patient started insulin therapy and treatment for AD with prednisolone and fludrocortisone with good clinical response.'?,"Yes, it is indirectly supported. The mention of prednisolone being used in treatment for AD (adrenal insufficiency) suggests that it can be an effective treatment, even if it does not specifically state that it is used to treat chronic primary adrenal insufficiency." +21254689,Prednisolone treats hypersensitivity pneumonitis,1100,We aimed to determine the effect of mycophenolate mofetil (MMF) and azathioprine (AZA) on lung function and prednisolone dose in cHP patients.,False,Is the triple 'Prednisolone treats hypersensitivity pneumonitis' supported by the sentence: 'We aimed to determine the effect of mycophenolate mofetil (MMF) and azathioprine (AZA) on lung function and prednisolone dose in cHP patients.'?,"No, it is not directly supported because it does not mention any relationship between Prednisolone and hypersensitivity pneumonitis (cHP). It only mentions that prednisolone dose is being studied in relation to MMF and AZA in cHP patients, not specifically in relation to treating hypersensitivity pneumonitis." +20836940,Prednisolone treats juvenile idiopathic arthritis,1101,"Here, we report the case of an 8-year-old girl with a 5-year history of multiple subcutaneous nodules on her extremities and a right wrist joint contracture who had been previously diagnosed with juvenile idiopathic arthritis and treated with salazosulfapyridine, low-dose prednisolone (PSL) and methotrexate.",True,"Is the triple 'Prednisolone treats juvenile idiopathic arthritis' supported by the sentence: 'Here, we report the case of an 8-year-old girl with a 5-year history of multiple subcutaneous nodules on her extremities and a right wrist joint contracture who had been previously diagnosed with juvenile idiopathic arthritis and treated with salazosulfapyridine, low-dose prednisolone (PSL) and methotrexate.'?","Yes, it is supported. The given sentence mentions a case of a patient with juvenile idiopathic arthritis who was treated with low-dose prednisolone (PSL), which implies that prednisolone is used as a treatment for this condition." +20612701,Prednisolone treats myocarditis,1102,This is a case of EGPA relapse presenting as myocarditis despite treatment with prednisolone.,True,Is the triple 'Prednisolone treats myocarditis' supported by the sentence: 'This is a case of EGPA relapse presenting as myocarditis despite treatment with prednisolone.'?,"Yes, it is indirectly supported. The statement suggests that despite treatment with prednisolone, a patient experienced a relapse of eosinophilic granulomatosis with polyangiitis (EGPA) that presented as myocarditis. This implies that prednisolone may not always effectively treat myocarditis associated with EGPA, but it doesn't necessarily mean that prednisolone has no therapeutic effect on myocarditis. It's important to note that individual patient responses can vary, and other factors could have influenced this particular patient's outcome." +17604301,Prednisolone treats cataract,1103,"Her visual acuity remained stable, despite development of a cataract from prednisolone therapy.",True,"Is the triple 'Prednisolone treats cataract' supported by the sentence: 'Her visual acuity remained stable, despite development of a cataract from prednisolone therapy.'?","Yes, it is indirectly supported because it suggests that while prednisolone therapy may cause cataracts (as indicated by 'development of a cataract'), it does not necessarily lead to a decrease in visual acuity (as indicated by 'visual acuity remained stable'). This implies that prednisolone may not be directly treating the cataracts (because they still developed), but it is not causing the expected worsening of symptoms (stable visual acuity)." +17312178,Prednisolone treats type 2 diabetes mellitus,1104,"In this study, we hypothesized that concomitant administration of the dipeptidyl peptidase-4 inhibitor sitagliptin and prednisolone in men at high risk to develop type 2 diabetes could protect against the GC-induced diabetogenic effects.",True,"Is the triple 'Prednisolone treats type 2 diabetes mellitus' supported by the sentence: 'In this study, we hypothesized that concomitant administration of the dipeptidyl peptidase-4 inhibitor sitagliptin and prednisolone in men at high risk to develop type 2 diabetes could protect against the GC-induced diabetogenic effects.'?","Yes, it is indirectly supported because it suggests that prednisolone may have diabetogenic effects when administered alone in men at high risk for developing Type 2 diabetes. However, when administered concomitantly with a dipeptidyl peptidase-4 inhibitor like sitagliptin, it may not induce these diabetogenic effects. This implies that prednisolone does not directly treat Type 2 diabetes but its effects can be managed when used with other medications like sitagliptin." +17184322,Prednisolone treats croup,1105,"Although common practice, evidence to support treatment of croup with prednisolone is scant.",False,"Is the triple 'Prednisolone treats croup' supported by the sentence: 'Although common practice, evidence to support treatment of croup with prednisolone is scant.'?","No, it is not directly nor indirectly supported. The statement suggests that while prednisolone is commonly used for treating croup, there is limited scientific evidence supporting its use." +16852549,Prednisolone treats mature T-cell and NK-cell non-Hodgkin lymphoma,1106,"Treatment of peripheral T cell lymphoma with an intensive protocol ACEP (adriamycin, cyclophosphamide, etoposide and prednisolone) and ifosfamide showing an important response and overall survival rates.",True,"Is the triple 'Prednisolone treats mature T-cell and NK-cell non-Hodgkin lymphoma' supported by the sentence: 'Treatment of peripheral T cell lymphoma with an intensive protocol ACEP (adriamycin, cyclophosphamide, etoposide and prednisolone) and ifosfamide showing an important response and overall survival rates.'?","Yes, it is indirectly supported, as the sentence mentions Prednisolone as part of a treatment protocol for a type of non-Hodgkin lymphoma, which aligns with the statement about Prednisolone treating certain types of non-Hodgkin lymphoma. However, it's important to note that this doesn't directly prove that Prednisolone alone is effective, as it's used in combination with other drugs in the treatment protocol." +16360878,Prednisolone treats ophthalmic herpes zoster,1107,"Herpes zoster ophthalmicus was suspected and treatment with i.v. acyclovir and prednisolone was commenced, which led to a gradual improvement of the clinical condition.",True,"Is the triple 'Prednisolone treats ophthalmic herpes zoster' supported by the sentence: 'Herpes zoster ophthalmicus was suspected and treatment with i.v. acyclovir and prednisolone was commenced, which led to a gradual improvement of the clinical condition.'?","Yes, the statement does provide some level of support for the idea that Prednisolone is used in the treatment of ophthalmic herpes zoster (herpes zoster ophthalmicus). However, it's important to note that this is an observational statement, not a controlled study, so it doesn't prove a causal relationship between Prednisolone and improvement in clinical condition. It could be that the improvement was due to the i.v. acyclovir, to Prednisolone, to both, or to some other factor not mentioned in the statement." +15441636,Prednisolone treats lipoma,1108,"Lipomas responded with less lipolysis to isoproterenol than subcutaneous fat during microdialysis, and prednisolone treatment increased lipolysis in both lipomas and subcutaneous fat.",True,"Is the triple 'Prednisolone treats lipoma' supported by the sentence: 'Lipomas responded with less lipolysis to isoproterenol than subcutaneous fat during microdialysis, and prednisolone treatment increased lipolysis in both lipomas and subcutaneous fat.'?","Yes, it is indirectly supported. The statement suggests that prednisolone can increase lipolysis (the breakdown of fat) in both lipomas (benign fatty tumors) and subcutaneous fat, which implies that it could potentially have a treating effect on lipomas, as reducing the size of a tumor often involves breaking down its constituent cells. However, it's important to note that this is a indirect inference, as the original statement does not explicitly say that prednisolone treats lipomas, but rather it suggests a potential mechanism for how it might do so." +15369817,Prednisolone treats pericarditis,1109,Treatment with prednisolone improved the pericarditis and motor nerve disturbance and the treatment with intravenous immunoglobulin improved the sensory nerve disturbance.,True,Is the triple 'Prednisolone treats pericarditis' supported by the sentence: 'Treatment with prednisolone improved the pericarditis and motor nerve disturbance and the treatment with intravenous immunoglobulin improved the sensory nerve disturbance.'?,"Yes, it is indirectly supported because treatment of pericarditis with Prednisolone is mentioned as effective, but it does not directly state that Prednisolone is used to treat pericarditis specifically in a triple formulation, nor does it mention sensory nerve disturbance being treated with Prednisolone, as it is in the case of intravenous immunoglobulin in this example." +15104714,Prednisolone treats pulmonary eosinophilia,1110,"Airway macrophage median percentage of red-hued area in stained sputum cytospin preparations was assessed by means of image analysis from (1) subjects with mild-to-severe asthma, subjects with nonasthmatic eosinophilic bronchitis, and healthy control subjects; (2) subjects with eosinophilic severe asthma after treatment with prednisolone; and (3) subject with noneosinophilic asthma before corticosteroid withdrawal.",True,"Is the triple 'Prednisolone treats pulmonary eosinophilia' supported by the sentence: 'Airway macrophage median percentage of red-hued area in stained sputum cytospin preparations was assessed by means of image analysis from (1) subjects with mild-to-severe asthma, subjects with nonasthmatic eosinophilic bronchitis, and healthy control subjects; (2) subjects with eosinophilic severe asthma after treatment with prednisolone; and (3) subject with noneosinophilic asthma before corticosteroid withdrawal.'?","Yes, it is indirectly supported because the mention of prednisolone treatment in subjects with eosinophilic severe asthma suggests a potential therapeutic effect on eosinophilic conditions, such as pulmonary eosinophilia, which is often associated with asthma. However, it's important to note that this is an inference based on a related context, not a direct statement about prednisolone's effect on pulmonary eosinophilia." +14992803,Prednisolone treats aplastic anemia,1111,"We report a case of subcutaneous abscess caused by Nocardia farcinica in a 44-year-old man, who had been treated with systemic prednisolone and cyclosporin for aplastic anemia.",True,"Is the triple 'Prednisolone treats aplastic anemia' supported by the sentence: 'We report a case of subcutaneous abscess caused by Nocardia farcinica in a 44-year-old man, who had been treated with systemic prednisolone and cyclosporin for aplastic anemia.'?","Yes, it is indirectly supported. The patient in question was being treated with prednisolone for aplastic anemia, and developed a subcutaneous abscess caused by Nocardia farcinica, which suggests that prednisolone may not have been entirely effective in treating the aplastic anemia, as it did not prevent the infection. However, this does not necessarily mean that prednisolone is not effective in treating aplastic anemia, as there could be other factors at play, such as the patient's immune system status, dosage, duration, etc." +14742554,Prednisolone treats psoriasis,1112,Genetically determined coincidence of Kaposi sarcoma and psoriasis in an HIV-negative patient after prednisolone treatment.,True,Is the triple 'Prednisolone treats psoriasis' supported by the sentence: 'Genetically determined coincidence of Kaposi sarcoma and psoriasis in an HIV-negative patient after prednisolone treatment.'?,"Yes, it is indirectly supported, as it suggests that prednisolone treatment is associated with an occurrence of a condition (Kaposi sarcoma) in a patient with psoriasis, implying that prednisolone might have an effect on psoriasis, although not directly treating it in this case." +14676056,Prednisolone treats habitual spontaneous abortion,1113,Prednisolone Trial: Study protocol for a randomised controlled trial of prednisolone for women with idiopathic recurrent miscarriage and raised levels of uterine natural killer (uNK) cells in the endometrium.,True,Is the triple 'Prednisolone treats habitual spontaneous abortion' supported by the sentence: 'Prednisolone Trial: Study protocol for a randomised controlled trial of prednisolone for women with idiopathic recurrent miscarriage and raised levels of uterine natural killer (uNK) cells in the endometrium.'?,"Yes, it is indirectly supported because prednisolone is being studied as a potential treatment for women with idiopathic recurrent miscarriage who have raised levels of uterine natural killer (uNK) cells in the endometrium, which suggests that prednisolone might be useful in treating recurrent miscarriage, a form of habitual spontaneous abortion. However, it's important to note that this study is still ongoing, so any definitive conclusions would be premature." +14345678,Prednisolone treats thrombotic thrombocytopenic purpura,1114,"The second was a 6-year-old boy with acquired relapsing TTP previously managed with plasmapheresis and prednisolone, who presented with a third relapse that was treated with plasmapheresis and rituximab; he remains in remission 17 months after treatment.",True,"Is the triple 'Prednisolone treats thrombotic thrombocytopenic purpura' supported by the sentence: 'The second was a 6-year-old boy with acquired relapsing TTP previously managed with plasmapheresis and prednisolone, who presented with a third relapse that was treated with plasmapheresis and rituximab; he remains in remission 17 months after treatment.'?","Yes, it is indirectly supported because it mentions a case of a patient with TTP who was previously managed with prednisolone, implying that prednisolone was used as a treatment for TTP in that case." +14012190,Prednisolone treats angioimmunoblastic T-cell lymphoma,1115,"Three months later, AILD relapsed in spite of prednisolone treatment.",False,"Is the triple 'Prednisolone treats angioimmunoblastic T-cell lymphoma' supported by the sentence: 'Three months later, AILD relapsed in spite of prednisolone treatment.'?","No, it is not directly or indirectly supported by that sentence. The relapse of a disease despite treatment does not confirm that the treatment is effective against it, but rather suggests that it may not be sufficient on its own, or that the disease is particularly aggressive or resistant to treatment." +13758030,Prednisolone treats optic neuritis,1116,Acute generalized exanthematous pustulosis induced by high-dose prednisolone in a young woman with optic neuritis owing to disseminated encephalomyelitis.,True,Is the triple 'Prednisolone treats optic neuritis' supported by the sentence: 'Acute generalized exanthematous pustulosis induced by high-dose prednisolone in a young woman with optic neuritis owing to disseminated encephalomyelitis.'?,"Yes, it is indirectly supported because it mentions prednisolone being used in a case of optic neuritis, even though it's in the context of a side effect (acute generalized exanthematous pustulosis) from high-dose prednisolone." +13566191,Prednisolone treats follicular lymphoma,1117,"The addition of rituximab to cyclophosphamide, vincristine and prednisolone (CVP) for advanced follicular lymphoma increases median time to progression by 17 months.",True,"Is the triple 'Prednisolone treats follicular lymphoma' supported by the sentence: 'The addition of rituximab to cyclophosphamide, vincristine and prednisolone (CVP) for advanced follicular lymphoma increases median time to progression by 17 months.'?","Yes, it is indirectly supported because it mentions that prednisolone is used in combination with other drugs for treating advanced follicular lymphoma, which suggests its efficacy in treating this type of cancer, even though it does not explicitly state that prednisolone alone can treat follicular lymphoma." +13327146,Prednisolone treats allergic bronchopulmonary aspergillosis,1118,"Here 2 cases of allergic bronchopulmonary aspergillosis in a family (brother and sister), treated with prednisolone with complete remission are reported.",True,"Is the triple 'Prednisolone treats allergic bronchopulmonary aspergillosis' supported by the sentence: 'Here 2 cases of allergic bronchopulmonary aspergillosis in a family (brother and sister), treated with prednisolone with complete remission are reported.'?","Yes, it is indirectly supported, as it mentions two cases of allergic bronchopulmonary aspergillosis that were treated with prednisolone with complete remission, suggesting that prednisolone may be an effective treatment for this condition." +13311736,Prednisolone treats neoplasm,1119,FDG-PET was performed in rats bearing BCG granulomas or tumors before and after prednisolone treatment.,False,Is the triple 'Prednisolone treats neoplasm' supported by the sentence: 'FDG-PET was performed in rats bearing BCG granulomas or tumors before and after prednisolone treatment.'?,"No, it is not directly supported because treating tumors with prednisolone does not necessarily mean that prednisolone is effective for treating all types of neoplasms (abnormal growths that may be benign or malignant). The statement also does not provide information about whether prednisolone has any effect on the growth of tumors, which is what one would expect when treating a neoplasm (abnormal growth). The statement only indicates that FDG-PET scans were conducted on rats with granulomas (small nodular inflammations) or tumors before and after prednisolone treatment, but it does not provide data on the outcomes of these treatments, such as reduced size of tumors, absence of tumors, etc." +12767794,Prednisolone treats pneumonia,1120,"After recovering from pneumonia, she was treated initially with prednisolone, 30 mg/day, and remained well until she developed hemoptysis at age 34 years.",True,"Is the triple 'Prednisolone treats pneumonia' supported by the sentence: 'After recovering from pneumonia, she was treated initially with prednisolone, 30 mg/day, and remained well until she developed hemoptysis at age 34 years.'?","Yes, it is indirectly supported. The given sentence suggests that prednisolone was used in the treatment of a patient who had recovered from pneumonia and remained well until a later age. This implies that prednisolone might have contributed to her recovery or maintenance of health after pneumonia, although it doesn't directly state that prednisolone is a treatment for pneumonia itself." +12190701,Prednisolone treats castration-resistant prostate carcinoma,1121,Fifteen patients 60 to 80 years old (a mean of 72 years) with hormone-refractory prostate cancer were treated with low dose prednisolone.,True,Is the triple 'Prednisolone treats castration-resistant prostate carcinoma' supported by the sentence: 'Fifteen patients 60 to 80 years old (a mean of 72 years) with hormone-refractory prostate cancer were treated with low dose prednisolone.'?,"Yes, it is indirectly supported because both statements refer to the use of prednisolone in treating hormone-refractory, which is a type of castration-resistant, prostate cancer in older male patients, without specifying a particular dosage regimen that would contradict this connection." +11988157,Prednisolone treats diffuse large B-cell lymphoma,1122,"CHOP (cyclophosphamide, doxorubicin, vincristine and prednisolone) has been the standard chemotherapy regimen used for diffuse large cell lymphomas for over 30 years.",True,"Is the triple 'Prednisolone treats diffuse large B-cell lymphoma' supported by the sentence: 'CHOP (cyclophosphamide, doxorubicin, vincristine and prednisolone) has been the standard chemotherapy regimen used for diffuse large cell lymphomas for over 30 years.'?","Yes, it is indirectly supported. The statement mentions that CHOP, a chemotherapy regimen that includes prednisolone, has been used for treating diffuse large B-cell lymphomas for over 30 years, implying that prednisolone is part of a treatment for this type of cancer." +11889996,Prednisolone treats mucocutaneous lymph node syndrome,1123,"Six patients with Kawasaki disease (KD) were treated with prednisolone (1 to 2 mg/kg/day) for 3 days (from days 10 to 12 after the onset of the illness) after apparently unsuccessful treatment with intravenous immunoglobulin (IVIG, 2 g/kg/dose and additional 1 g/kg/dose).",True,"Is the triple 'Prednisolone treats mucocutaneous lymph node syndrome' supported by the sentence: 'Six patients with Kawasaki disease (KD) were treated with prednisolone (1 to 2 mg/kg/day) for 3 days (from days 10 to 12 after the onset of the illness) after apparently unsuccessful treatment with intravenous immunoglobulin (IVIG, 2 g/kg/dose and additional 1 g/kg/dose).'?","Yes, the statement does provide some level of support for the idea that prednisolone can be used to treat mucocutaneous lymph node syndrome, which is another name for Kawasaki disease (KD). However, it's important to note that this is a case study of six patients, not a large-scale clinical trial, so it doesn't definitively prove that prednisolone is an effective treatment for KD. It does, however, suggest that further research into this area might be warranted." +11813573,Prednisolone treats focal segmental glomerulosclerosis,1124,"RESULTS: Of 136 patients with primary FSGS and nephrotic range proteinuria, 76 (56%) were treated with prednisolone and of this group, 59% were treated with additional immunosuppression.",True,"Is the triple 'Prednisolone treats focal segmental glomerulosclerosis' supported by the sentence: 'RESULTS: Of 136 patients with primary FSGS and nephrotic range proteinuria, 76 (56%) were treated with prednisolone and of this group, 59% were treated with additional immunosuppression.'?","Yes, it is indirectly supported because it mentions that prednisolone was used to treat primary FSGS with nephrotic range proteinuria, but it does not directly state that prednisolone treats focal segmental glomerulosclerosis (FSGS). Additionally, it mentions that additional immunosuppression was used in a majority of cases, which suggests a more complex treatment approach for FSGS." +11810617,Prednisolone treats congenital adrenal hyperplasia,1125,"METHODS: Growth parameters of twelve children (8 m, 4 f) with congenital adrenal hyperplasia were retrospectively studied while on treatment with prednisolone (PR) earlier and then hydrocortisone (HC) after it became freely available in India.",True,"Is the triple 'Prednisolone treats congenital adrenal hyperplasia' supported by the sentence: 'METHODS: Growth parameters of twelve children (8 m, 4 f) with congenital adrenal hyperplasia were retrospectively studied while on treatment with prednisolone (PR) earlier and then hydrocortisone (HC) after it became freely available in India.'?","Yes, it is indirectly supported because it mentions that growth parameters of children with congenital adrenal hyperplasia were studied while on treatment with prednisolone, implying that prednisolone is used to treat this condition. However, it does not explicitly state that prednisolone treats congenital adrenal hyperplasia, hence it is indirect support." +11808057,Prednisolone treats keratitis,1126,Ciprofloxacin and prednisolone therapy for experimental Pseudomonas keratitis.,True,Is the triple 'Prednisolone treats keratitis' supported by the sentence: 'Ciprofloxacin and prednisolone therapy for experimental Pseudomonas keratitis.'?,"Yes, it is indirectly supported. The mention of 'prednisolone' in the context of treating 'keratitis' in experimental Pseudomonas, implies that prednisolone can be used for treating certain types of keratitis, even though it doesn't explicitly state that it treats all types of keratitis, such as those caused by other organisms." +11527350,"Prednisolone treats dermatitis, atopic",1127,"Prednicarbate is a non-halogenated, double-ester derivative of prednisolone that has become of interest for the treatment of inflammatory skin diseases, for example atopic dermatitis.",True,"Is the triple 'Prednisolone treats dermatitis, atopic' supported by the sentence: 'Prednicarbate is a non-halogenated, double-ester derivative of prednisolone that has become of interest for the treatment of inflammatory skin diseases, for example atopic dermatitis.'?","Yes, it is indirectly supported because prednicarbate is a derivative of prednisolone, which is used to treat atopic dermatitis, implying that prednisolone has efficacy in treating this condition." +11526277,Prednisolone treats kidney disorder,1128,"AIM: To evaluate the efficacy of prednisolone, warfarin, and dipyridamole therapy combined with mizoribine (PWDM) in the treatment of diffuse immunoglobulin A (IgA) nephropathy in comparison with prednisolone, warfarin, and dipyridamole therapy without mizoribine (PWD) and with methylprednisolone pulse therapy (PWD pulse).",True,"Is the triple 'Prednisolone treats kidney disorder' supported by the sentence: 'AIM: To evaluate the efficacy of prednisolone, warfarin, and dipyridamole therapy combined with mizoribine (PWDM) in the treatment of diffuse immunoglobulin A (IgA) nephropathy in comparison with prednisolone, warfarin, and dipyridamole therapy without mizoribine (PWD) and with methylprednisolone pulse therapy (PWD pulse).'?","Yes, it is indirectly supported because it mentions that Prednisolone is used in treating a type of kidney disorder called diffuse immunoglobulin A (IgA) nephropathy in a clinical trial setting, implying its therapeutic potential for kidney disorders, though it does not explicitly state that Prednisolone 'treats' a kidney disorder, but rather it is being evaluated for its efficacy in treating a specific type of kidney disease in this study." +11497678,Prednisolone treats infertility disorder,1129,"In this double blind cross-over study, 20 infertile men, who had sperm antibodies detected by the mixed antiglobulin reaction (MAR test) in the ejaculate and by the tray agglutination test (TAT) in serum, were treated with 40 mg/day prednisolone or placebo from days 1 to 10 of the partners' menstrual cycle.",True,"Is the triple 'Prednisolone treats infertility disorder' supported by the sentence: 'In this double blind cross-over study, 20 infertile men, who had sperm antibodies detected by the mixed antiglobulin reaction (MAR test) in the ejaculate and by the tray agglutination test (TAT) in serum, were treated with 40 mg/day prednisolone or placebo from days 1 to 10 of the partners' menstrual cycle.'?","Yes, it is indirectly supported because prednisolone was used in a study on men with sperm antibodies, which can be a factor in infertility disorders. However, the statement does not explicitly say that prednisolone treats infertility disorders, but rather it was used in a study related to a possible cause of infertility in men." +11373326,Prednisolone treats prostate cancer,1130,BACKGROUND: We conducted this retrospective study to analyze a modified dose schedule of mitoxantrone and prednisolone (MP) in patients with androgen-independent prostate cancer.,False,Is the triple 'Prednisolone treats prostate cancer' supported by the sentence: 'BACKGROUND: We conducted this retrospective study to analyze a modified dose schedule of mitoxantrone and prednisolone (MP) in patients with androgen-independent prostate cancer.'?,"No, it is not directly nor indirectly supported, as it does not mention that Prednisolone is used for treating prostate cancer, but rather analyzes a modified dose schedule of mitoxantrone and prednisolone in patients with a specific type of prostate cancer." +11166363,Prednisolone treats canker sore,1131,"It has also been used in combination with other drugs for treating a number of dermatologic disorders, e.g. in combination with cimetidine for treating recalcitrant warts, with prednisolone for treating lichen planus, erythema multiforme and aphthous ulcers of the mouth.",True,"Is the triple 'Prednisolone treats canker sore' supported by the sentence: 'It has also been used in combination with other drugs for treating a number of dermatologic disorders, e.g. in combination with cimetidine for treating recalcitrant warts, with prednisolone for treating lichen planus, erythema multiforme and aphthous ulcers of the mouth.'?","Yes, it is supported, as prednisolone is mentioned to be used for treating aphthous ulcers of the mouth, which is a type of canker sore." +11166362,Prednisolone treats lichen planus,1132,"It has also been used in combination with other drugs for treating a number of dermatologic disorders, e.g. in combination with cimetidine for treating recalcitrant warts, with prednisolone for treating lichen planus, erythema multiforme and aphthous ulcers of the mouth.",True,"Is the triple 'Prednisolone treats lichen planus' supported by the sentence: 'It has also been used in combination with other drugs for treating a number of dermatologic disorders, e.g. in combination with cimetidine for treating recalcitrant warts, with prednisolone for treating lichen planus, erythema multiforme and aphthous ulcers of the mouth.'?","Yes, the statement does provide support for the claim that Prednisolone is used to treat lichen planus, as it explicitly mentions this use case in combination with other drugs." +11166361,Prednisolone treats erythema multiforme,1133,"It has also been used in combination with other drugs for treating a number of dermatologic disorders, e.g. in combination with cimetidine for treating recalcitrant warts, with prednisolone for treating lichen planus, erythema multiforme and aphthous ulcers of the mouth.",True,"Is the triple 'Prednisolone treats erythema multiforme' supported by the sentence: 'It has also been used in combination with other drugs for treating a number of dermatologic disorders, e.g. in combination with cimetidine for treating recalcitrant warts, with prednisolone for treating lichen planus, erythema multiforme and aphthous ulcers of the mouth.'?","Yes, the statement does provide indirect support for the claim that Prednisolone can be used to treat erythema multiforme, as it mentions its use in treating this condition when combined with other drugs." +10782301,Prednisolone treats adrenocortical insufficiency,1134,Prednisolone in the treatment of adrenal insufficiency: a re-evaluation of relative potency.,True,Is the triple 'Prednisolone treats adrenocortical insufficiency' supported by the sentence: 'Prednisolone in the treatment of adrenal insufficiency: a re-evaluation of relative potency.'?,"Yes, it is directly related as prednisolone is being re-evaluated for its potency in treating adrenal insufficiency, which is a form of adrenocortical insufficiency." +10757066,Prednisolone treats atopic eczema,1135,[Results of prednisolone therapy of eczemas in very young and older infants].,True,Is the triple 'Prednisolone treats atopic eczema' supported by the sentence: '[Results of prednisolone therapy of eczemas in very young and older infants].'?,"Yes, it is indirectly supported because the title suggests a study on the effects of Prednisolone on eczemas, which implies that it could be used to treat atopic eczema in different age groups, including infants. However, it does not directly state that Prednisolone treats atopic eczema." +10671990,Prednisolone treats Headache,1136,"We report a patient with neuro-Behcet's syndrome presenting with headache and personality change in whom CT and MRI brain imaging was normal, but regional cerebral blood flow imaging using single photon emission tomography with the tracer HMPAO showed extensive perfusion deficits which partially reversed after 3 months of prednisolone therapy.",True,"Is the triple 'Prednisolone treats Headache' supported by the sentence: 'We report a patient with neuro-Behcet's syndrome presenting with headache and personality change in whom CT and MRI brain imaging was normal, but regional cerebral blood flow imaging using single photon emission tomography with the tracer HMPAO showed extensive perfusion deficits which partially reversed after 3 months of prednisolone therapy.'?","Yes, it is indirectly supported because it suggests that prednisolone therapy can potentially improve cerebral blood flow, which could in turn alleviate headaches, but it doesn't directly state that prednisolone treats headaches." +10574410,Prednisolone treats synovitis,1137,Prednisolone (meticortelone) in treatment of epicondylitis; radiohumeral bursitis and radiohumeral synovitis.,True,Is the triple 'Prednisolone treats synovitis' supported by the sentence: 'Prednisolone (meticortelone) in treatment of epicondylitis; radiohumeral bursitis and radiohumeral synovitis.'?,"Yes, it is indirectly supported because epicondylitis, radiohumeral bursitis, and radiohumeral synovitis all involve inflammation in different parts of the body, and Prednisolone is used to treat these conditions, suggesting it has anti-inflammatory properties which could potentially be used to treat synovitis." +10574409,Prednisolone treats epicondylitis,1138,Prednisolone (meticortelone) in treatment of epicondylitis; radiohumeral bursitis and radiohumeral synovitis.,True,Is the triple 'Prednisolone treats epicondylitis' supported by the sentence: 'Prednisolone (meticortelone) in treatment of epicondylitis; radiohumeral bursitis and radiohumeral synovitis.'?,"Yes, the statement ""Prednisolone (meticortelone) in treatment of epicondylitis; radiohumeral bursitis and radiohumeral synovitis."" does provide indirect support for the claim that Prednisolone treats epicondylitis, as it mentions Prednisolone as a treatment for epicondylitis. However, it's important to note that this is not a direct citation or scientific study, so it should be further verified with more robust evidence." +10565149,Prednisolone treats osteoarthritis,1139,"Intra-articular injections of hydrocortisone prednisolone, and their tertiary-butylacetate derivatives in patients with rheumatoid arthritis and osteoarthritis.",True,"Is the triple 'Prednisolone treats osteoarthritis' supported by the sentence: 'Intra-articular injections of hydrocortisone prednisolone, and their tertiary-butylacetate derivatives in patients with rheumatoid arthritis and osteoarthritis.'?","Yes, it is indirectly supported because both prednisolone and hydrocortisone (which is a type of corticosteroid) have been used as treatments for arthritic conditions, including osteoarthritis, as mentioned in the provided sentence. However, it's important to note that this does not necessarily mean that prednisolone specifically is used to treat osteoarthritis, but rather that it is a type of treatment used for this condition. Always consult with a healthcare professional for medical advice." +10557390,Prednisolone treats peptic ulcer disease,1140,On the development of peptic ulcers in patients treated with prednisone or prednisolone.,False,Is the triple 'Prednisolone treats peptic ulcer disease' supported by the sentence: 'On the development of peptic ulcers in patients treated with prednisone or prednisolone.'?,"No, it is not directly or indirectly supported. The original statement discusses prednisONE, while the second statement discusses prednisOLONE, which, although similar, are not identical drugs with identical effects. Furthermore, the second statement does not provide any information about treating or preventing peptic ulcers, but rather mentions their development during treatment with certain drugs, one of which is prednisOLONE, not prednisONE." +10513879,Prednisolone treats celiac disease,1141,The simultaneous correction of plain-water deficit and extracellular fluid volume loss in non-tropical sprue treated with prednisolone.,False,Is the triple 'Prednisolone treats celiac disease' supported by the sentence: 'The simultaneous correction of plain-water deficit and extracellular fluid volume loss in non-tropical sprue treated with prednisolone.'?,"No, it is not directly supported because treating water deficit and fluid volume loss does not necessarily mean treating celiac disease. However, it can be interpreted as an indirect effect, as prednisolone might help manage symptoms associated with celiac disease, but it does not cure it." +10509017,Prednisolone treats hepatocellular carcinoma,1142,"One had received four weekly cycles of prednisolone, Adriamycin, vincristine and 5-fluorouracil for an inoperable HCC with a 10-cm diameter, and the other had received localised synchronised hepatic irradiation and Adriamycin.",False,"Is the triple 'Prednisolone treats hepatocellular carcinoma' supported by the sentence: 'One had received four weekly cycles of prednisolone, Adriamycin, vincristine and 5-fluorouracil for an inoperable HCC with a 10-cm diameter, and the other had received localised synchronised hepatic irradiation and Adriamycin.'?","No, it is not directly supported because Prednisolone is mentioned along with other treatments, but it does not explicitly state that Prednisolone was used to treat hepatocellular carcinoma (HCC) in this particular context." +10502737,Prednisolone treats hemolytic anemia,1143,"[A case of hemolytic anemia with generalized agglutination, treated with ACTH, cortisone, and prednisolone].",True,"Is the triple 'Prednisolone treats hemolytic anemia' supported by the sentence: '[A case of hemolytic anemia with generalized agglutination, treated with ACTH, cortisone, and prednisolone].'?","Yes, it is indirectly supported. The provided sentence mentions that prednisolone was used to treat a case of hemolytic anemia, which aligns with the statement that prednisolone treats hemolytic anemia, although it does not explicitly state that prednisolone was solely responsible for treating the condition in this particular case." +10335998,Prednisolone treats pemphigus,1144,"OBJECTIVES: The present study describes our experience of the addition of mycophenolate mofetil (MMF) to prednisolone in the management of severe, refractory pemphigus.",True,"Is the triple 'Prednisolone treats pemphigus' supported by the sentence: 'OBJECTIVES: The present study describes our experience of the addition of mycophenolate mofetil (MMF) to prednisolone in the management of severe, refractory pemphigus.'?","Yes, it is indirectly supported. The statement mentions that prednisolone is used in combination with mycophenolate mofetil (MMF) in managing severe, refractory pemphigus, suggesting that prednisolone is indeed a treatment for pemphigus, as stated in your triple quote." +10020250,Prednisolone treats Hodgkins lymphoma,1145,"Under the diagnosis of Hodgkin's disease, she was treated with combination chemotherapy containing pirarubicin, cyclophosphamide, vincristine, and prednisolone.",True,"Is the triple 'Prednisolone treats Hodgkins lymphoma' supported by the sentence: 'Under the diagnosis of Hodgkin's disease, she was treated with combination chemotherapy containing pirarubicin, cyclophosphamide, vincristine, and prednisolone.'?","Yes, it is indirectly supported because prednisolone is mentioned as part of a treatment regimen for a patient diagnosed with Hodgkin's disease, which is another term for Hodgkin's lymphoma. However, it's important to note that prednisolone is used in combination with other drugs, suggesting that it may not be effective on its own in treating Hodgkin's lymphoma." +9848677,Prednisolone treats Inflammation,1146,"Patients who remain high transporters with inflammatory reaction might require pharmacologic intervention, including prednisolone therapy.",True,"Is the triple 'Prednisolone treats Inflammation' supported by the sentence: 'Patients who remain high transporters with inflammatory reaction might require pharmacologic intervention, including prednisolone therapy.'?","Yes, it is indirectly supported. The statement suggests that pharmacologic intervention, including prednisolone therapy, might be necessary for patients who have an inflammatory reaction and are high transporters, implying that prednisolone could be used to treat inflammation." +9729887,Prednisolone treats glomerulonephritis,1147,"[Comparative characteristics of the spectrum of free amino acids of blood serum and urine in children with glomerulonephritis treated with prednisolone, leukeran and anabolic steroids].",True,"Is the triple 'Prednisolone treats glomerulonephritis' supported by the sentence: '[Comparative characteristics of the spectrum of free amino acids of blood serum and urine in children with glomerulonephritis treated with prednisolone, leukeran and anabolic steroids].'?","Yes, it is indirectly supported. The title suggests that the study is investigating the effects of Prednisolone, Leukeran, and anabolic steroids on children with glomerulonephritis, implying that Prednisolone is used as a treatment for this condition. However, it does not directly state that Prednisolone treats glomerulonephritis." +9717382,Prednisolone treats hemangioma,1148,"Management of hemangioma included observation, prednisolone, flashlamp-pumped pulsed-dye laser, topical therapy and excision in 68 per cent, 8.6 per cent, 10.7 per cent, 9.6 per cent, and 2.5 per cent, respectively.",True,"Is the triple 'Prednisolone treats hemangioma' supported by the sentence: 'Management of hemangioma included observation, prednisolone, flashlamp-pumped pulsed-dye laser, topical therapy and excision in 68 per cent, 8.6 per cent, 10.7 per cent, 9.6 per cent, and 2.5 per cent, respectively.'?","Yes, it is indirectly supported because the management options for hemangioma include prednisolone as one of them, which suggests that prednisolone is used in treating hemangioma in some cases." +9668241,Prednisolone treats pure red-cell aplasia,1149,The PRCA and AIHA were successfully treated with prednisolone.,True,Is the triple 'Prednisolone treats pure red-cell aplasia' supported by the sentence: 'The PRCA and AIHA were successfully treated with prednisolone.'?,"Yes, it is indirectly supported, as both diseases, PRCA (pure red cell aplasia) and AIHA (autoimmune hemolytic anemia), were treated with prednisolone, suggesting that prednisolone could be an effective treatment for PRCA, which is a type of pure red cell aplasia." +9538921,Prednisolone treats Graves disease,1150,"She was diagnosed as having Graves' disease and was treated with propylthiouracil, and prednisolone was given for neck pain.",True,"Is the triple 'Prednisolone treats Graves disease' supported by the sentence: 'She was diagnosed as having Graves' disease and was treated with propylthiouracil, and prednisolone was given for neck pain.'?","Yes, it is indirectly supported. The person in question has been diagnosed with Graves' disease, which is being treated with propylthiouracil, a common drug used to manage hyperthyroidism, which is a symptom of Graves' disease. Additionally, prednisolone is being given for neck pain, which means that prednisolone is being used concurrently with a treatment for Graves' disease, although it is not directly treating the Graves' disease itself in this context." +9135976,Prednisolone treats sarcoidosis,1151,"Clinical characteristics, pulmonary function abnormalities and outcome of prednisolone treatment in 106 patients with sarcoidosis.",True,"Is the triple 'Prednisolone treats sarcoidosis' supported by the sentence: 'Clinical characteristics, pulmonary function abnormalities and outcome of prednisolone treatment in 106 patients with sarcoidosis.'?","Yes, it is indirectly supported because the title mentions prednisolone treatment in patients with sarcoidosis, which suggests that prednisolone is used to treat sarcoidosis. However, for a direct correlation, the article would need to explicitly state that prednisolone treats sarcoidosis." +9109448,Prednisolone treats psoriatic arthritis,1152,Methotrexate and prednisolone treatment of a child with psoriatic arthritis.,False,Is the triple 'Prednisolone treats psoriatic arthritis' supported by the sentence: 'Methotrexate and prednisolone treatment of a child with psoriatic arthritis.'?,"No, it is not directly supported because the given sentence discusses Methotrexate in addition to Prednisolone, not Prednisolone alone for treating psoriatic arthritis in a child." +9077262,Prednisolone treats lymphoma,1153,"This paper presents the results of a prospective study to investigate the prognostic value of clinical staging, histological grading, immunophenotype, mitotic count and average numbers of argyrophilic nucleolar organiser region counts in dogs with multicentric lymphosarcoma treated with a standard chemotherapy protocol comprising vincristine, cyclophosphamide and prednisolone.",True,"Is the triple 'Prednisolone treats lymphoma' supported by the sentence: 'This paper presents the results of a prospective study to investigate the prognostic value of clinical staging, histological grading, immunophenotype, mitotic count and average numbers of argyrophilic nucleolar organiser region counts in dogs with multicentric lymphosarcoma treated with a standard chemotherapy protocol comprising vincristine, cyclophosphamide and prednisolone.'?","Yes, it is indirectly supported. The sentence mentions that prednisolone is used in the treatment protocol for dogs with multicentric lymphosarcoma, which suggests that prednisolone is used in treating this type of cancer, thus providing some support for the claim that prednisolone treats lymphoma. However, it does not directly state that prednisolone treats lymphoma, hence it's an indirect support." +9061500,Prednisolone treats dermatomyositis,1154,"The administration of prednisolone (60 mg/day) was initiated, which resulted in improvement of DM.",True,"Is the triple 'Prednisolone treats dermatomyositis' supported by the sentence: 'The administration of prednisolone (60 mg/day) was initiated, which resulted in improvement of DM.'?","Yes, it is indirectly supported. The improvement in Dermatomyositis (DM) upon administration of Prednisolone suggests that Prednisolone is an effective treatment for Dermatomyositis, which aligns with the statement that Prednisolone treats Dermatomyositis." +9046445,Prednisolone treats systemic sclerosis,1155,"METHODS: Resting radionuclide ventriculography with 99mTc was performed before and 20 days after the administration of prednisolone, 20 mg daily, in 32 patients with SSc without clinically evident myocardial dysfunction at rest; 13 and 19 patients with systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA), respectively, were studied in parallel as controls.",True,"Is the triple 'Prednisolone treats systemic sclerosis' supported by the sentence: 'METHODS: Resting radionuclide ventriculography with 99mTc was performed before and 20 days after the administration of prednisolone, 20 mg daily, in 32 patients with SSc without clinically evident myocardial dysfunction at rest; 13 and 19 patients with systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA), respectively, were studied in parallel as controls.'?","Yes, it is indirectly supported because it mentions a study where prednisolone was administered to patients with systemic sclerosis (SSc). However, it does not explicitly state that prednisolone treats SSc, but rather that a study was conducted using it on SSc patients." +9013774,Prednisolone treats ocular pemphigoid,1156,METHODS: Three patients with CP were treated with mycophenolate mofetil and prednisolone.,True,Is the triple 'Prednisolone treats ocular pemphigoid' supported by the sentence: 'METHODS: Three patients with CP were treated with mycophenolate mofetil and prednisolone.'?,"Yes, it is indirectly supported because prednisolone is mentioned as a treatment for three patients with corticosteroids (CP), which is a common treatment for ocular pemphigoid. However, it does not directly state that prednisolone is used specifically for treating ocular pemphigoid in this scenario, so it is an indirect association." +8939337,Prednisolone treats membranous glomerulonephritis,1157,He was diagnosed as having membranous nephropathy by renal biopsy and was treated with prednisolone.,True,Is the triple 'Prednisolone treats membranous glomerulonephritis' supported by the sentence: 'He was diagnosed as having membranous nephropathy by renal biopsy and was treated with prednisolone.'?,"Yes, it is indirectly supported because it mentions that a patient with membranous nephropathy, a type of glomerulonephritis, was treated with prednisolone, which is a type of corticosteroid often used to treat membranous glomerulonephritis. However, it does not explicitly state that prednisolone treats membranous glomerulonephritis, but rather that it was used in the treatment of a patient with this condition." +8906209,Prednisolone treats allergic disease,1158,"Clinically, both prednisolone and prednisolone sodium succinate are widely used as immunosuppressive agents for the treatment of various allergic disorders.",True,"Is the triple 'Prednisolone treats allergic disease' supported by the sentence: 'Clinically, both prednisolone and prednisolone sodium succinate are widely used as immunosuppressive agents for the treatment of various allergic disorders.'?","Yes, it is indirectly supported because it mentions that Prednisolone is used for treating various allergic disorders as an immunosuppressive agent, which implies that it can help manage symptoms of allergic diseases." +8865745,Prednisolone treats subacute thyroiditis,1159,CONCLUSIONS: The recurrence rate of SAT with treated PSL is about 20%.,True,Is the triple 'Prednisolone treats subacute thyroiditis' supported by the sentence: 'CONCLUSIONS: The recurrence rate of SAT with treated PSL is about 20%.'?,"Yes, it is indirectly supported because Prednisolone (PSL) is used to treat Subacute Thyroiditis (SAT), and the conclusion suggests that about 20% of SAT cases treated with PSL may experience a recurrence, implying a relationship between PSL treatment and SAT outcomes." +8819323,Prednisolone treats meningeal tuberculosis,1160,"In this case, prednisolone was indispensable for treating tuberculous meningitis in combination with appropriate antituberculosis drugs, though the role of corticosteroids has remained controversial over the years.",True,"Is the triple 'Prednisolone treats meningeal tuberculosis' supported by the sentence: 'In this case, prednisolone was indispensable for treating tuberculous meningitis in combination with appropriate antituberculosis drugs, though the role of corticosteroids has remained controversial over the years.'?","Yes, it is indirectly supported. The given sentence mentions that prednisolone was used in combination with appropriate antituberculosis drugs to treat tuberculous meningitis, which suggests that prednisolone can be effective in treating meningeal tuberculosis. However, it also mentions that the role of corticosteroids (which includes prednisolone) has been controversial, indicating that more research is needed to fully understand its effectiveness and appropriate use in such cases." +8755027,Prednisolone treats hypereosinophilic syndrome,1161,"Prednisolone (PSL) was administered, which improved the anemia, eosinophilia and the cavities.",True,"Is the triple 'Prednisolone treats hypereosinophilic syndrome' supported by the sentence: 'Prednisolone (PSL) was administered, which improved the anemia, eosinophilia and the cavities.'?","Yes, it is indirectly supported because prednisolone was administered to treat a condition, which resulted in an improvement of eosinophilia, which is a symptom of hypereosinophilic syndrome, as well as anemia, which could also be a symptom of this condition. However, it's important to note that this is an indirect inference, as the original sentence does not explicitly state that prednisolone was used to treat hypereosinophilic syndrome." +8752241,Prednisolone treats West syndrome,1162,"BACKGROUND: The use of adrenocorticotrophic hormone (ACTH) and prednisolone in the management of infantile spasms has been well established, but is associated with significant morbidity and cannot be used as long-term medication.",True,"Is the triple 'Prednisolone treats West syndrome' supported by the sentence: 'BACKGROUND: The use of adrenocorticotrophic hormone (ACTH) and prednisolone in the management of infantile spasms has been well established, but is associated with significant morbidity and cannot be used as long-term medication.'?","Yes, it is indirectly supported. The background information states that prednisolone has been established in managing infantile spasms (which is a type of West syndrome), but its long-term use is associated with significant morbidity, implying that it is used for treatment, not prevention or cure." +8647269,Prednisolone treats pulmonary tuberculosis,1163,"However, he died because of lung tuberculosis and acute tuberculous pericarditis during treatment with prednisolone.",True,"Is the triple 'Prednisolone treats pulmonary tuberculosis' supported by the sentence: 'However, he died because of lung tuberculosis and acute tuberculous pericarditis during treatment with prednisolone.'?","Yes, it is indirectly supported. The mention of prednisolone in conjunction with a worsening condition (death due to lung tuberculosis and acute tubercular pericarditis) suggests that prednisolone may not be an effective treatment for pulmonary tuberculosis. However, it does not directly state that prednisolone is used to treat pulmonary tuberculosis in this context." +8583398,Prednisolone treats leprosy,1164,"In untreated reactional leprosy patients, the levels of urinary NO metabolites (1645 +/- 454 microM, n = 9, ENL = 4, RR = 5) decreased significantly 2 weeks after high dose prednisolone treatment (1075 +/- 414 microM, P < 0.05), and remained stable 4 (895 +/- 385 microM, P < 0.02) and 6 weeks following treatment initiation (1048 +/- 452 microM, P < 0.02).",False,"Is the triple 'Prednisolone treats leprosy' supported by the sentence: 'In untreated reactional leprosy patients, the levels of urinary NO metabolites (1645 +/- 454 microM, n = 9, ENL = 4, RR = 5) decreased significantly 2 weeks after high dose prednisolone treatment (1075 +/- 414 microM, P < 0.05), and remained stable 4 (895 +/- 385 microM, P < 0.02) and 6 weeks following treatment initiation (1048 +/- 452 microM, P < 0.02).'?","No, this statement does not directly support that Prednisolone treats leprosy. It suggests that Prednisolone may have an effect on certain markers (urinary NO metabolites) in reactional leprosy patients, but it does not confirm that it treats leprosy itself." +8573433,Prednisolone treats alcoholic hepatitis,1165,"Prednisolone improves survival in patients with alcoholic hepatitis who have either spontaneous hepatic encephalopathy or a high ""discriminant function.",True,"Is the triple 'Prednisolone treats alcoholic hepatitis' supported by the sentence: 'Prednisolone improves survival in patients with alcoholic hepatitis who have either spontaneous hepatic encephalopathy or a high ""discriminant function.'?","Yes, it is indirectly supported because both statements refer to treatment of alcoholic hepatitis with Prednisolone, but the second statement provides additional conditions (spontaneous hepatic encephalopathy or a high discriminant function) under which Prednisolone is said to improve survival." +8540122,Prednisolone treats autoimmune hemolytic anemia,1166,She had received prednisolone (PSL) therapy for autoimmune hemolytic anemia (AIHA).,True,Is the triple 'Prednisolone treats autoimmune hemolytic anemia' supported by the sentence: 'She had received prednisolone (PSL) therapy for autoimmune hemolytic anemia (AIHA).'?,"Yes, it is indirectly supported because it mentions that PSL therapy was given for AIHA, which suggests that PSL can be used to treat AIHA, as stated in your original statement, but it doesn't explicitly confirm that PSL treats AIHA, hence it's indirect support." +8499057,Prednisolone treats lupus nephritis,1167,"CONCLUSIONS: For the treatment of diffuse proliferative lupus nephritis, the combination of mycophenolate mofetil and prednisolone is as effective as a regimen of cyclophosphamide and prednisolone followed by azathioprine and prednisolone but is less toxic.",True,"Is the triple 'Prednisolone treats lupus nephritis' supported by the sentence: 'CONCLUSIONS: For the treatment of diffuse proliferative lupus nephritis, the combination of mycophenolate mofetil and prednisolone is as effective as a regimen of cyclophosphamide and prednisolone followed by azathioprine and prednisolone but is less toxic.'?","Yes, it is indirectly supported because the conclusion suggests that prednisolone, in combination with other drugs, is effective in treating diffuse proliferative lupus nephritis, which is a form of lupus nephritis." +8455402,Prednisolone treats chronic obstructive pulmonary disease,1168,Additive effects of prednisolone and beclomethasone dipropionate in patients with stable chronic obstructive pulmonary disease.,True,Is the triple 'Prednisolone treats chronic obstructive pulmonary disease' supported by the sentence: 'Additive effects of prednisolone and beclomethasone dipropionate in patients with stable chronic obstructive pulmonary disease.'?,"Yes, it is indirectly supported. The given sentence suggests that Prednisolone, when used in combination with Beclomethasone Dipropionate, has additive effects in treating stable Chronic Obstructive Pulmonary Disease (COPD). Therefore, it implies that Prednisolone has a role in treating COPD, which aligns with the statement that Prednisolone treats COPD, although directly, it does not state that Prednisolone alone is effective in treating COPD." +8268574,Prednisolone treats thrombocytopenia,1169,Three out of 8 patients with thrombocytopenia were treated with prednisolone according to the protocol for idiopathic thrombocytopenic purpura.,True,Is the triple 'Prednisolone treats thrombocytopenia' supported by the sentence: 'Three out of 8 patients with thrombocytopenia were treated with prednisolone according to the protocol for idiopathic thrombocytopenic purpura.'?,"Yes, it is indirectly supported, as it suggests that prednisolone is a treatment option for some cases of idiopathic thrombocytopenic purpura, a condition characterized by low platelet count (thrombocytopenia). However, it does not directly state that prednisolone treats thrombocytopenia itself, but rather a condition that can cause it." +7990669,Prednisolone treats non-Hodgkin lymphoma,1170,"A regimen which incorporates cyclophosphamide, doxorubicin, vincristine and prednisolone (CHOP) is the standard treatment for patients with non-Hodgkin's lymphoma (NHL), but it has not been effective in patients with aggressive NHL who are at high risk.",True,"Is the triple 'Prednisolone treats non-Hodgkin lymphoma' supported by the sentence: 'A regimen which incorporates cyclophosphamide, doxorubicin, vincristine and prednisolone (CHOP) is the standard treatment for patients with non-Hodgkin's lymphoma (NHL), but it has not been effective in patients with aggressive NHL who are at high risk.'?","Yes, it is indirectly supported. Prednisolone is a component of the CHOP regimen, which is a standard treatment for patients with non-Hodgkin's lymphoma (NHL). However, the sentence suggests that this treatment may not be effective in patients with aggressive NHL who are at high risk, implying that while Prednisolone is used in treating NHL, it may not be sufficient in certain cases." +7986379,Prednisolone treats Crohn disease,1171,"In a stepwise regression that included age, sex, disease duration and cumulative prednisolone dose as independent variables, the femur T score was significantly inversely related to disease duration (r2 = 0.125, F = 6.06) in CD patients.",False,"Is the triple 'Prednisolone treats Crohn disease' supported by the sentence: 'In a stepwise regression that included age, sex, disease duration and cumulative prednisolone dose as independent variables, the femur T score was significantly inversely related to disease duration (r2 = 0.125, F = 6.06) in CD patients.'?","No, it is not directly nor indirectly supported by this statement. This statement is about an inverse relationship between femur T score (a bone density measurement) with disease duration in patients with Crohn's disease (CD), not about the therapeutic effect of Prednisolone on CD itself." +7985554,Prednisolone treats acute lymphoblastic leukemia,1172,"A regime of treatment of acute non-lymphoblastic leukemia in adult, employing DMCP protocol, especially two step method consisting of daunorubicin, cytosine arabinoside, 6-mercaptopurine and prednisolone is described.",True,"Is the triple 'Prednisolone treats acute lymphoblastic leukemia' supported by the sentence: 'A regime of treatment of acute non-lymphoblastic leukemia in adult, employing DMCP protocol, especially two step method consisting of daunorubicin, cytosine arabinoside, 6-mercaptopurine and prednisolone is described.'?","Yes, the statement does provide some support for the idea that Prednisolone is used in the treatment of leukemia, specifically in a two-step method for treating acute non-lymphoblastic leukemia in adults as part of the DMCP protocol, which includes daunorubicin, cytosine arabinoside, and 6-mercaptopurine. However, it does not directly support the treatment of acute lymphoblastic leukemia with Prednisolone." +7941298,Prednisolone treats granulomatosis with polyangiitis,1173,"Two patients with Wegener's granulomatosis have been treated with chlorambucil and prednisolone continuosly for 3 and 5 years, respectively.",True,"Is the triple 'Prednisolone treats granulomatosis with polyangiitis' supported by the sentence: 'Two patients with Wegener's granulomatosis have been treated with chlorambucil and prednisolone continuosly for 3 and 5 years, respectively.'?","Yes, it is indirectly supported because it mentions the use of prednisolone in treating a type of granulomatosis with polyangiitis (Wegener's granulomatosis) in combination with chlorambucil, which suggests that prednisolone is part of the treatment regimen for this condition." +7927983,Prednisolone treats nephrotic syndrome,1174,"The second patient, a 73-year-old man receiving prednisolone therapy for nephrotic syndrome, developed right leg cellulitis that evolved to NF.",True,"Is the triple 'Prednisolone treats nephrotic syndrome' supported by the sentence: 'The second patient, a 73-year-old man receiving prednisolone therapy for nephrotic syndrome, developed right leg cellulitis that evolved to NF.'?","Yes, it is indirectly supported. The mention of a 73-year-old man receiving prednisolone therapy for nephrotic syndrome who developed cellulitis suggests that prednisolone is used as a treatment for nephrotic syndrome. However, it does not directly state that prednisolone treats nephrotic syndrome, but rather implies it." +7900660,Prednisolone treats temporal arteritis,1175,"At the time of diagnosis, patients with GCA had an increased median serum level of YKL-40 (256 microg/liter; P<0.01) compared with healthy age-matched controls (median 118 microg/liter), and the serum level of YKL-40 decreased to normal levels during prednisolone treatment (-38% after 1 month; P<0.001).",True,"Is the triple 'Prednisolone treats temporal arteritis' supported by the sentence: 'At the time of diagnosis, patients with GCA had an increased median serum level of YKL-40 (256 microg/liter; P<0.01) compared with healthy age-matched controls (median 118 microg/liter), and the serum level of YKL-40 decreased to normal levels during prednisolone treatment (-38% after 1 month; P<0.001).'?","Yes, this statement does provide some evidence that Prednisolone may help treat Temporal Arteritis (Giant Cell Arteritis). The research shows that when patients diagnosed with Temporal Arteritis have an increased YKL-40 serum level compared to healthy age-matched controls, treatment using Prednisolone results in a significant decrease in YKL-40 levels after one month. This suggests that Prednisolone could be an effective treatment for Temporal Arteritis as it helps normalize YKL-40 levels in these patients. However, further research would be required to establish a direct causal relationship between Prednisolone treatment and improvement in Temporal Arteritis symptoms." +7900659,Prednisolone treats polymyalgia rheumatica,1176,Most patients with PMR had normal serum YKL-40 levels (median 158 microg/liter) and had no changes in the serum YKL-40 levels during prednisolone treatment.,False,Is the triple 'Prednisolone treats polymyalgia rheumatica' supported by the sentence: 'Most patients with PMR had normal serum YKL-40 levels (median 158 microg/liter) and had no changes in the serum YKL-40 levels during prednisolone treatment.'?,"No, it is not directly supported because there is no mention of Prednisolone treating polymyalgia rheumatica (PMR) in the provided sentence. The sentence only states that most patients with PMR had normal serum YKL-40 levels and had no changes in serum YKL-40 levels during prednisolone treatment, but it does not imply that Prednisolone is used to treat PMR." +7866839,Prednisolone treats acute myeloid leukemia,1177,"Treatment of acute myeloid leukemia of childhood with cytosine arabinoside, daunorubicin, prednisolone, and mercaptopurine or thioguanine.",True,"Is the triple 'Prednisolone treats acute myeloid leukemia' supported by the sentence: 'Treatment of acute myeloid leukemia of childhood with cytosine arabinoside, daunorubicin, prednisolone, and mercaptopurine or thioguanine.'?","Yes, it is indirectly supported, as prednisolone is mentioned as one of the potential treatments for acute myeloid leukemia in children in combination with other drugs in the provided sentence." +7819165,Prednisolone treats systemic lupus erythematosus,1178,Subacute severe steatohepatitis during prednisolone therapy for systemic lupus erythematosis.,True,Is the triple 'Prednisolone treats systemic lupus erythematosus' supported by the sentence: 'Subacute severe steatohepatitis during prednisolone therapy for systemic lupus erythematosis.'?,"Yes, it is indirectly supported. The given sentence suggests that prednisolone is used in the treatment of systemic lupus erythematosis, and it mentions a side effect (subacute severe steatohepatitis) that occurred during this therapy. This implies that prednisolone has a therapeutic effect on systemic lupus erythematosis, even though it may also have side effects." +7800931,Prednisolone treats autoimmune thrombocytopenic purpura,1179,"However, after administration of immunoglobulin (IVIG) (0.4 g/kg/day x 5 days), low-dose PSL (20 mg/day) alleviated the LEMS and ITP, and the diseases have remained in remission for 8 months without additional IVIG.",True,"Is the triple 'Prednisolone treats autoimmune thrombocytopenic purpura' supported by the sentence: 'However, after administration of immunoglobulin (IVIG) (0.4 g/kg/day x 5 days), low-dose PSL (20 mg/day) alleviated the LEMS and ITP, and the diseases have remained in remission for 8 months without additional IVIG.'?","Yes, it is indirectly supported. The statement mentions that low-dose Prednisolone (PSL) was used in conjunction with immunoglobulin (IVIG) to treat autoimmune thrombocytopenic purpura (ITP) and Lambert-Eaton myasthenic syndrome (LEMS), and that the patient has remained in remission for 8 months without additional IVIG. This suggests that Prednisolone can be an effective treatment for ITP, which aligns with the statement that Prednisolone treats autoimmune thrombocytopenic purpura." +7704078,Prednisolone treats colitis,1180,"On the other hand, prednisolone and short chain fatty acids seemed to improve only the physiologic changes of colitis.",True,"Is the triple 'Prednisolone treats colitis' supported by the sentence: 'On the other hand, prednisolone and short chain fatty acids seemed to improve only the physiologic changes of colitis.'?","Yes, it is indirectly supported. The statement suggests that prednisolone has a positive effect on physiologic changes in colitis, which could be interpreted as an improvement in the condition of colitis, even though it doesn't explicitly say that prednisolone treats colitis." +7676165,Prednisolone treats hypercalcemia disease,1181,"Treatment with extracorporeal shock wave lithotripsy, transurethral lithotomy, saline infusion, and prednisolone (30 mg/day) alleviated the urolithiasis, renal insufficiency, and hypercalcemia.",True,"Is the triple 'Prednisolone treats hypercalcemia disease' supported by the sentence: 'Treatment with extracorporeal shock wave lithotripsy, transurethral lithotomy, saline infusion, and prednisolone (30 mg/day) alleviated the urolithiasis, renal insufficiency, and hypercalcemia.'?","Yes, it is. The given sentence indicates that treatment involving prednisolone (30 mg/day) helped alleviate hypercalcemia, which suggests that prednisolone could be effective in treating hypercalcemia. However, it's important to note that this is an indirect inference, as the primary focus of the treatment seems to be urolithiasis and renal insufficiency, not specifically hypercalcemia." +7603475,Prednisolone treats Duchenne muscular dystrophy,1182,A special program for long-term application of low-dose prednisolone treatment in Duchenne-Becker muscular dystrophy with complex control of the patients' state was developed.,True,Is the triple 'Prednisolone treats Duchenne muscular dystrophy' supported by the sentence: 'A special program for long-term application of low-dose prednisolone treatment in Duchenne-Becker muscular dystrophy with complex control of the patients' state was developed.'?,"Yes, it is indirectly supported. The provided sentence mentions a long-term application of low-dose prednisolone treatment in Duchenne-Becker muscular dystrophy, which implies that prednisolone is used as a treatment option for this condition. However, it does not explicitly state that prednisolone treats Duchenne muscular dystrophy, hence it's an indirect support." +7600829,Prednisolone treats multiple sclerosis,1183,"Long-term open-trial of mizoribine with prednisolone in 24 patients with multiple sclerosis: safety, clinical and magnetic resonance imaging outcome.",False,"Is the triple 'Prednisolone treats multiple sclerosis' supported by the sentence: 'Long-term open-trial of mizoribine with prednisolone in 24 patients with multiple sclerosis: safety, clinical and magnetic resonance imaging outcome.'?","No, it is not directly supported because the study is about Mizoribine with Prednisolone, not Prednisolone alone in treating Multiple Sclerosis." +7586864,Prednisolone treats ulcerative colitis,1184,A 25-year-old man had been treated with high-dose prednisolone for UC.,True,Is the triple 'Prednisolone treats ulcerative colitis' supported by the sentence: 'A 25-year-old man had been treated with high-dose prednisolone for UC.'?,"Yes, it is indirectly supported. The mention of a 25-year-old man being treated with high-dose prednisolone for UC suggests that prednisolone is used in the treatment of ulcerative colitis. However, it does not explicitly state that prednisolone treats ulcerative colitis, hence it's an indirect support." +7485161,Prednisolone treats uveitis,1185,DISCUSSION: Allopurinol is more effective than prednisolone in treating EAU.,False,Is the triple 'Prednisolone treats uveitis' supported by the sentence: 'DISCUSSION: Allopurinol is more effective than prednisolone in treating EAU.'?,"No, it's not. The sentence discusses the effectiveness of Allopurinol compared to Prednisolone in treating EAU (Experimental Autoimmune Uveoretinitis), not uveitis specifically." +7430895,Prednisolone treats asthma,1186,"Interleukin-5 mRNA was detected in all asthmatics before prednisolone therapy; however, after prednisolone therapy, IL-5 mRNA was only detected in non-GCS-responsive BHR asthmatics.",True,"Is the triple 'Prednisolone treats asthma' supported by the sentence: 'Interleukin-5 mRNA was detected in all asthmatics before prednisolone therapy; however, after prednisolone therapy, IL-5 mRNA was only detected in non-GCS-responsive BHR asthmatics.'?","Yes, it is indirectly supported. The presence of Interleukin-5 (IL-5) mRNA before prednisolone therapy suggests that prednisolone may have an effect on IL-5, which is associated with asthma. After prednisolone therapy, IL-5 mRNA is still present in non-GCS-responsive BHR asthmatics, suggesting that prednisolone may not be as effective in treating this subset of asthmatics. Therefore, prednisolone can be said to treat asthma, but its effectiveness may vary depending on the individual's responsiveness to glucocorticoid steroids (GCS)." +7417999,Prednisolone treats IgA glomerulonephritis,1187,"Combined therapy with prednisolone, azathioprine, heparin-warfarin, and dipyridamole for paediatric patients with severe IgA nephropathy--is it relevant for adult patients?",True,"Is the triple 'Prednisolone treats IgA glomerulonephritis' supported by the sentence: 'Combined therapy with prednisolone, azathioprine, heparin-warfarin, and dipyridamole for paediatric patients with severe IgA nephropathy--is it relevant for adult patients?'?","Yes, it is indirectly supported, as it suggests that Prednisolone can be used in treating severe cases of IgA nephropathy, which is a type of glomerulonephritis, in paediatric patients, implying that it may also be relevant for adult patients, although it is not specifically mentioned in the provided context." +7158230,Prednisolone treats rheumatoid arthritis,1188,Remission of the nephrotic syndrome in a patient with renal amyloidosis due to rheumatoid arthritis treated with prednisolone and methotrexate.,True,Is the triple 'Prednisolone treats rheumatoid arthritis' supported by the sentence: 'Remission of the nephrotic syndrome in a patient with renal amyloidosis due to rheumatoid arthritis treated with prednisolone and methotrexate.'?,"Yes, it is indirectly supported, as prednisolone is used to treat a symptom (nephrotic syndrome) caused by rheumatoid arthritis, which aligns with the claim that prednisolone can treat rheumatoid arthritis. However, it does not directly support the claim that prednisolone specifically treats rheumatoid arthritis, as it could be treating a symptom rather than the disease itself in this case." +23769275,Hydrocortisone treats leukemia,1189,"Study protocol: DexaDays-2, hydrocortisone for treatment of dexamethasone-induced neurobehavioral side effects in pediatric leukemia patients: a double-blind placebo controlled randomized intervention study with cross-over design.",True,"Is the triple 'Hydrocortisone treats leukemia' supported by the sentence: 'Study protocol: DexaDays-2, hydrocortisone for treatment of dexamethasone-induced neurobehavioral side effects in pediatric leukemia patients: a double-blind placebo controlled randomized intervention study with cross-over design.'?","Yes, it is indirectly supported. The study mentions hydrocortisone being used in a treatment context for pediatric leukemia patients, although it's not specifically stated that hydrocortisone is used to treat leukemia itself, but rather to manage side effects of another treatment (dexamethasone)." +22345112,Hydrocortisone treats oral submucous fibrosis,1190,"Aims and Objective: To evaluate the efficacy of injection placentrex and injection hydrocortisone in oral submucous fibrosis patients in increasing mouth opening, burning sensation, and improve the mucosal lining.",True,"Is the triple 'Hydrocortisone treats oral submucous fibrosis' supported by the sentence: 'Aims and Objective: To evaluate the efficacy of injection placentrex and injection hydrocortisone in oral submucous fibrosis patients in increasing mouth opening, burning sensation, and improve the mucosal lining.'?","Yes, it is indirectly supported because it mentions injection hydrocortisone being used in a study on treating oral submucous fibrosis, which suggests a potential positive effect on mouth opening, burning sensation, and mucosal lining in patients with this condition. However, it does not directly state that hydrocortisone is a treatment for oral submucous fibrosis, so further research would be necessary to confirm this hypothesis." +22282269,Hydrocortisone treats Infection,1191,"The results presented herein imply that the three families of cyanine dyes, in particular compounds 5a-f, show high potential as selective scaffolds to treat C. albicans infections.",False,"Is the triple 'Hydrocortisone treats Infection' supported by the sentence: 'The results presented herein imply that the three families of cyanine dyes, in particular compounds 5a-f, show high potential as selective scaffolds to treat C. albicans infections.'?","No, it is not directly or indirectly supported, because there is no mention of Hydrocortisone in the given sentence, nor any implication about it treating infections. The sentence discusses cyanine dyes as potential treatments for C. albicans infections, not Hydrocortisone." +21368080,Hydrocortisone treats lymphoma,1192,The serum cortisol concentration in the LYMPH patients was 285 +/- 74 nmol/l.,False,Is the triple 'Hydrocortisone treats lymphoma' supported by the sentence: 'The serum cortisol concentration in the LYMPH patients was 285 +/- 74 nmol/l.'?,"No, it is not directly or indirectly supported by that statement alone, as it does not specify that Hydrocortisone was used to treat the patients, nor does it provide a direct correlation between Hydrocortisone treatment and changes in lymphoma condition." +19834754,Hydrocortisone treats cardiac arrest,1193,"Compared to controls, glycocalyx was mildly injured by CA, severely disrupted by hyaluronidase (HAase) with CA, and mitigated by hydrocortisone (HC) with CA.",True,"Is the triple 'Hydrocortisone treats cardiac arrest' supported by the sentence: 'Compared to controls, glycocalyx was mildly injured by CA, severely disrupted by hyaluronidase (HAase) with CA, and mitigated by hydrocortisone (HC) with CA.'?","Yes, it is indirectly supported because it mentions that hydrocortisone (HC) has a mitigating effect on the injury caused by cardiac arrest (CA), but it does not explicitly state that it treats it." +17499762,Hydrocortisone treats dermatitis,1194,"In the acute phase of dermatitis, topical hydrocortisone treatment has both a local and a systemic effect, due to percutaneous absorption.",True,"Is the triple 'Hydrocortisone treats dermatitis' supported by the sentence: 'In the acute phase of dermatitis, topical hydrocortisone treatment has both a local and a systemic effect, due to percutaneous absorption.'?","Yes, it is indirectly supported because it mentions that topical hydrocortisone treatment is used in the acute phase of dermatitis, which suggests it can be used to treat dermatitis, even though it doesn't explicitly say so in those exact words." +16946872,Hydrocortisone treats adrenal cortex neoplasm,1195,"The mean (+/- SD) plasma cortisol concentration for the initial 8-hour testing period was highest in 18 dogs with adrenocortical tumor (5.3 +/- 1.6 micrograms/dl), lowest in 15 control dogs (1.3 +/- 0.5 micrograms/dl), and intermediate in 31 dogs with pituitary-dependent hyperadrenocorticism (PDH; 3.4 +/- 1.2 micrograms/dl).",True,"Is the triple 'Hydrocortisone treats adrenal cortex neoplasm' supported by the sentence: 'The mean (+/- SD) plasma cortisol concentration for the initial 8-hour testing period was highest in 18 dogs with adrenocortical tumor (5.3 +/- 1.6 micrograms/dl), lowest in 15 control dogs (1.3 +/- 0.5 micrograms/dl), and intermediate in 31 dogs with pituitary-dependent hyperadrenocorticism (PDH; 3.4 +/- 1.2 micrograms/dl).'?","Yes, it is supported, as per your provided data, dogs with adrenocortical tumor have higher levels of plasma cortisol (5.3 +/- 1.6 micrograms/dl) compared to control dogs (1.3 +/- 0.5 micrograms/dl). Hydrocortisone, a synthetic form of cortisol, could be used to treat such conditions to replace deficient hormones in case of adrenocortical tumor, thus treating the adrenal cortex neoplasm, directly or indirectly." +15753359,Hydrocortisone treats dissociative amnesia,1196,Our results suggest that PL may increase the availability of cortisol in chronically stressed men and may attenuate stress-induced memory impairments.,False,Is the triple 'Hydrocortisone treats dissociative amnesia' supported by the sentence: 'Our results suggest that PL may increase the availability of cortisol in chronically stressed men and may attenuate stress-induced memory impairments.'?,"No, it is not directly supported because hydrocortisone is a specific type of cortisol, but the statement discusses cortisol in general, not specifically hydrocortisone. Also, there is no mention of dissociative amnesia in the provided statement." +15602187,Hydrocortisone treats Hypoxemia,1197,All inhibitors prevented the rise in cortisol secretion usually observed in hypoxic dogs.,True,Is the triple 'Hydrocortisone treats Hypoxemia' supported by the sentence: 'All inhibitors prevented the rise in cortisol secretion usually observed in hypoxic dogs.'?,"Yes, it is indirectly supported. The statement suggests that hypoxic dogs treated with certain inhibitors did not experience an increase in cortisol secretion, which is typically seen in hypoxic conditions. Cortisol is a hormone produced by the adrenal gland, and hydrocortisone is a synthetic form of this hormone often used to treat various conditions, including hypoxemia (low oxygen levels in the blood). Therefore, if these inhibitors prevent an increase in natural cortisol, it could be hypothesized that administering hydrocortisone might have a similar effect, helping to regulate cortisol levels during hypoxic conditions. However, this is an interpretation based on a general understanding of hormonal regulation, and further research would be needed to confirm this hypothesis." +15325707,Hydrocortisone treats psoriasis,1198,"The expression of StAR and MLN64 was aberrant in two skin disorders, psoriasis and atopic dermatitis, that are commonly treated with cortisol, suggesting dysregulation of epidermal steroid synthesis in these patients.",True,"Is the triple 'Hydrocortisone treats psoriasis' supported by the sentence: 'The expression of StAR and MLN64 was aberrant in two skin disorders, psoriasis and atopic dermatitis, that are commonly treated with cortisol, suggesting dysregulation of epidermal steroid synthesis in these patients.'?","Yes, it is indirectly supported because Hydrocortisone is a type of cortisol, which is used to treat psoriasis, as suggested in the sentence that mentions cortisol being used to treat skin disorders, including psoriasis, due to potential dysregulation in epidermal steroid synthesis, which is related to Hydrocortisone's mechanism of action in treating this condition." +15213238,Hydrocortisone treats herpes labialis,1199,"ME-609 (Xerese, Xerclear) is a combination of 5% acyclovir and 1% hydrocortisone developed for the topical treatment of HSL.",True,"Is the triple 'Hydrocortisone treats herpes labialis' supported by the sentence: 'ME-609 (Xerese, Xerclear) is a combination of 5% acyclovir and 1% hydrocortisone developed for the topical treatment of HSL.'?","Yes, it is indirectly supported because both sentences mention hydrocortisone being used in the treatment of a condition, specifically Herpes Labialis in your original statement, which is also known as Cold Sores, and HSL in my statement, which is also a form of Herpes infection. However, it's important to note that hydrocortisone is often used to manage inflammation associated with these conditions, rather than directly treating the virus itself. Acyclovir, on the other hand, is an antiviral medication that directly combats the virus causing Herpes infections. Therefore, while related, the two sentences aren't directly about the same treatment process." +14532907,Hydrocortisone treats cirrhosis of liver,1200,The urinary ratio of 6 beta-hydroxycortisol/cortisol (6 beta-OHC/C) as a biomarker of CYP3A4 metabolizing activity has been studied in Egyptian patients with chronic liver cirrhosis associated with previous hepatic Schistosomiasis infection to determine any possible alteration in enzyme activity.,True,Is the triple 'Hydrocortisone treats cirrhosis of liver' supported by the sentence: 'The urinary ratio of 6 beta-hydroxycortisol/cortisol (6 beta-OHC/C) as a biomarker of CYP3A4 metabolizing activity has been studied in Egyptian patients with chronic liver cirrhosis associated with previous hepatic Schistosomiasis infection to determine any possible alteration in enzyme activity.'?,"Yes, it is indirectly supported because Hydrocortisone is a substrate for CYP3A4, an enzyme that can be affected in chronic liver diseases such as cirrhosis, as suggested in the study you mentioned with Egyptian patients with chronic liver cirrhosis associated with previous hepatic Schistosomiasis infection. The study investigates any possible alteration in CYP3A4 enzyme activity, which could impact Hydrocortisone metabolism in these patients, but it does not directly study Hydrocortisone's effect on treating cirrhosis of the liver." +14075841,Hydrocortisone treats acute lymphoblastic leukemia,1201,"Here, we report a case of fatal ATLS complicating intrathecal injections of methotrexate, cytarabine and hydrocortisone for acute lymphoblastic leukemia which relapsed with meningeal involvement after allogeneic stem cell transplantation.",False,"Is the triple 'Hydrocortisone treats acute lymphoblastic leukemia' supported by the sentence: 'Here, we report a case of fatal ATLS complicating intrathecal injections of methotrexate, cytarabine and hydrocortisone for acute lymphoblastic leukemia which relapsed with meningeal involvement after allogeneic stem cell transplantation.'?","No, it is not directly or indirectly supported. The given sentence mentions hydrocortisone being used in treatment for relapsed acute lymphoblastic leukemia with meningeal involvement, but it does not provide any information about hydrocortisone's effectiveness in treating this condition, let alone specifically addressing acute lymphoblastic leukemia in general." +13951019,Hydrocortisone treats HIV infectious disease,1202,"Except in one patient with HIV infection, all the signs and symptoms improved after antituberculous and hydrocortisone treatment.",True,"Is the triple 'Hydrocortisone treats HIV infectious disease' supported by the sentence: 'Except in one patient with HIV infection, all the signs and symptoms improved after antituberculous and hydrocortisone treatment.'?","Yes, it is indirectly supported because it suggests that hydrocortisone treatment can improve symptoms in a patient with HIV infection. However, it does not directly state that hydrocortisone treats HIV infectious disease." +13724762,Hydrocortisone treats severe acute respiratory syndrome,1203,"Cortisol levels are elevated in patients with RSV and Ebola, and cortisol was higher in SARS patients with lymphopenia before any steroid therapy.",True,"Is the triple 'Hydrocortisone treats severe acute respiratory syndrome' supported by the sentence: 'Cortisol levels are elevated in patients with RSV and Ebola, and cortisol was higher in SARS patients with lymphopenia before any steroid therapy.'?","Yes, it is indirectly supported, as both RSV and Ebola have elevated cortisol levels, which is similar to SARS patients with lymphopenia before any steroid therapy, suggesting that hydrocortisone may help treat severe acute respiratory syndrome (SARS). However, this is an inference, not a direct statement, so it is an indirect support at best." +13691671,Hydrocortisone treats Insulin resistance,1204,OBJECTIVE: To investigate possible effects of insulin-sensitizing treatment on cortisol metabolism in insulin-resistant patients with polycystic ovary syndrome (PCOS).,True,Is the triple 'Hydrocortisone treats Insulin resistance' supported by the sentence: 'OBJECTIVE: To investigate possible effects of insulin-sensitizing treatment on cortisol metabolism in insulin-resistant patients with polycystic ovary syndrome (PCOS).'?,"Yes, it is indirectly supported. The objective of this study is to investigate potential effects of an insulin-sensitizing treatment on cortisol metabolism in patients with polycystic ovary syndrome (PCOS), a condition often associated with both insulin resistance and increased cortisol levels (which Hydrocortisone can affect). However, it does not explicitly mention Hydrocortisone in this particular study, so it is an indirect connection based on the broader context described in your statement." +12881395,Hydrocortisone treats myocardial infarction,1205,The paper yields the results of the study into the elimination of exogenous cortisol from the blood bed in 26 patients with myocardial infarction.,False,Is the triple 'Hydrocortisone treats myocardial infarction' supported by the sentence: 'The paper yields the results of the study into the elimination of exogenous cortisol from the blood bed in 26 patients with myocardial infarction.'?,"No, it is not directly nor indirectly supported, as there is no mention of Hydrocortisone in the provided sentence, nor any indication that it has a positive effect on patients with myocardial infarction in this context." +12524121,Hydrocortisone treats neoplasm,1206,"Retinoic acid treatment controls ACTH and cortisol hyperactivity and tumor size in dogs with ACTH-secreting tumors, leading to resolution of the clinical phenotype.",False,"Is the triple 'Hydrocortisone treats neoplasm' supported by the sentence: 'Retinoic acid treatment controls ACTH and cortisol hyperactivity and tumor size in dogs with ACTH-secreting tumors, leading to resolution of the clinical phenotype.'?","No, because hydrocortisone is a steroid hormone, while retinoic acid is a form of vitamin A, so they are not directly related in terms of treating neoplasms (tumors). The mechanism of action for retinoic acid in controlling ACTH and cortisol hyperactivity is different from that of hydrocortisone, which is a common medication used to replace cortisol in people with adrenal insufficiency, not a treatment for tumors." +11965490,Hydrocortisone treats injury,1207,Diurnal cortisol in schizophrenia patients with childhood trauma.,False,Is the triple 'Hydrocortisone treats injury' supported by the sentence: 'Diurnal cortisol in schizophrenia patients with childhood trauma.'?,"No, it is not directly or indirectly supported because there is no mention of Hydrocortisone, a synthetic form of cortisol, treating injuries in the given sentence about diurnal cortisol levels in schizophrenia patients with childhood trauma." +11029944,Hydrocortisone treats eye disorder,1208,Topical compound F in the treatment of anterior segment eye disease; a preliminary report.,False,Is the triple 'Hydrocortisone treats eye disorder' supported by the sentence: 'Topical compound F in the treatment of anterior segment eye disease; a preliminary report.'?,"No, it is not directly or indirectly supported because there is no mention of Hydrocortisone, an eye disorder, or a connection to anterior segment eye disease in the provided sentence." +10518308,Hydrocortisone treats ulcerative colitis,1209,Treatment of ulcerative colitis with local hydrocortisone.,True,Is the triple 'Hydrocortisone treats ulcerative colitis' supported by the sentence: 'Treatment of ulcerative colitis with local hydrocortisone.'?,"Yes, it is indirectly supported, as both sentences suggest a connection between hydrocortisone and the treatment of ulcerative colitis, even though they do not explicitly state that hydrocortisone is used to treat this condition in a triple formulation." +10516843,Hydrocortisone treats diffuse alopecia areata,1210,"Alopecia areata, partialis, and totalis; treatment with cortisone, hydrocortisone and their analogs, prednisone and prednisolone.",True,"Is the triple 'Hydrocortisone treats diffuse alopecia areata' supported by the sentence: 'Alopecia areata, partialis, and totalis; treatment with cortisone, hydrocortisone and their analogs, prednisone and prednisolone.'?","Yes, it is indirectly supported because hydrocortisone is mentioned as a treatment for alopecia areata, which is a type of hair loss. However, the specific type of alopecia arenata, diffuse, is not explicitly mentioned in the provided sentence." +10492262,Hydrocortisone treats osteoarthritis,1211,Phenylbutazone and compound F for osteoarthritis of the hip; a survey and clinical report.,False,Is the triple 'Hydrocortisone treats osteoarthritis' supported by the sentence: 'Phenylbutazone and compound F for osteoarthritis of the hip; a survey and clinical report.'?,"No, it is not directly nor indirectly supported by that sentence as it mentions Phenylbutazone and compound F, not Hydrocortisone as a treatment for osteoarthritis of the hip." +10480635,Hydrocortisone treats atopic conjunctivitis,1212,"Hydrocortisone in treatment of allergic conjunctivitis, allergic rhinitis, and bronchial asthma.",True,"Is the triple 'Hydrocortisone treats atopic conjunctivitis' supported by the sentence: 'Hydrocortisone in treatment of allergic conjunctivitis, allergic rhinitis, and bronchial asthma.'?","Yes, it is indirectly supported because hydrocortisone is mentioned as a treatment for allergic conjunctivitis, which is a type of atopic conjunctivitis, as well as for other allergic conditions such as allergic rhinitis and bronchial asthma." +10280121,Hydrocortisone treats melanoma,1213,"METHOD: Adrenocorticotropic hormone (ACTH), cortisol, and interleukin-6 (IL-6) plasma concentrations were measured in 14 patients with malignant melanoma at regular intervals during the first 12 weeks of IFN-alpha therapy, both immediately before and 1, 2, and 3 hours after IFN-alpha administration.",False,"Is the triple 'Hydrocortisone treats melanoma' supported by the sentence: 'METHOD: Adrenocorticotropic hormone (ACTH), cortisol, and interleukin-6 (IL-6) plasma concentrations were measured in 14 patients with malignant melanoma at regular intervals during the first 12 weeks of IFN-alpha therapy, both immediately before and 1, 2, and 3 hours after IFN-alpha administration.'?","No, it is not directly nor indirectly supported, as there is no mention of Hydrocortisone in this methodology description of measuring various plasma concentrations in patients with malignant melanoma during IFN-alpha therapy." +10221382,Hydrocortisone treats atopic eczema,1214,"These data show clobetasone butyrate 0.05% is more effective than 1.0% hydrocortisone in the treatment of eczema and more effective than flurandrenolone 0.0125% (p=0.01%) and a potent topical steroid hydrocortisone butyrate (p<0.05), in the treatment of psoriasis.",False,"Is the triple 'Hydrocortisone treats atopic eczema' supported by the sentence: 'These data show clobetasone butyrate 0.05% is more effective than 1.0% hydrocortisone in the treatment of eczema and more effective than flurandrenolone 0.0125% (p=0.01%) and a potent topical steroid hydrocortisone butyrate (p<0.05), in the treatment of psoriasis.'?","No, it is not directly or indirectly supported, as this statement compares clobetasone butyrate to hydrocortisone in treating eczema, but it does not mention hydrocortisone treating atopic eczema specifically, nor does it compare hydrocortisone to hydrocortisone butyrate, which is a different compound in a different concentration than standard hydrocortisone." +9971730,Hydrocortisone treats pneumonia,1215,The use of extracorporeal immunopharmacotherapy with diucifon in 53 patients and the retrosternal injection of isoniazid in combination with hydrocortisone in 43 patients have shown their efficiencies in the treatment of patients with caseous pneumonia.,True,Is the triple 'Hydrocortisone treats pneumonia' supported by the sentence: 'The use of extracorporeal immunopharmacotherapy with diucifon in 53 patients and the retrosternal injection of isoniazid in combination with hydrocortisone in 43 patients have shown their efficiencies in the treatment of patients with caseous pneumonia.'?,"Yes, it is indirectly supported because it mentions hydrocortisone in combination with isoniazid being used in the treatment of patients with caseous pneumonia, which is a type of pneumonia. However, it does not specifically state that hydrocortisone alone treats pneumonia." +9665107,Hydrocortisone treats prostate cancer,1216,"Therefore, a prospective phase II study was conducted to assess the efficacy and safety of a regimen of low dose (200 mg.) oral ketoconazole 3 times daily with replacement doses of hydrocortisone in men with androgen independent prostate cancer.",True,"Is the triple 'Hydrocortisone treats prostate cancer' supported by the sentence: 'Therefore, a prospective phase II study was conducted to assess the efficacy and safety of a regimen of low dose (200 mg.) oral ketoconazole 3 times daily with replacement doses of hydrocortisone in men with androgen independent prostate cancer.'?","Yes, it is indirectly supported. The mention of replacement doses of hydrocortisone in men with androgen independent prostate cancer suggests that hydrocortisone is used in treating this condition, although it's not specifically mentioned as a treatment for prostate cancer itself." +9535781,Hydrocortisone treats adrenocortical insufficiency,1217,"Long term hydrocortisone therapy for his adrenal insufficiency may have prevented a faster course of the liver disease, whereas the heterozygous alpha1-antitrypsin deficiency and moderate alcohol consumption constituted additional risk factors ultimately leading to the development of cirrhosis.",True,"Is the triple 'Hydrocortisone treats adrenocortical insufficiency' supported by the sentence: 'Long term hydrocortisone therapy for his adrenal insufficiency may have prevented a faster course of the liver disease, whereas the heterozygous alpha1-antitrypsin deficiency and moderate alcohol consumption constituted additional risk factors ultimately leading to the development of cirrhosis.'?","Yes, it is supported. The sentence mentions that long-term hydrocortisone therapy for adrenal insufficiency may have slowed down the progression of liver disease, implying that hydrocortisone can treat adrenocortical insufficiency and have a positive impact on related conditions like liver disease." +9459897,Hydrocortisone treats hypotensive disorder,1218,"After 24-h age, a subgroup (n = 8) received up to four doses (0.5-1.0 mg/kg each) of hydrocortisone for refractory hypotension.",True,"Is the triple 'Hydrocortisone treats hypotensive disorder' supported by the sentence: 'After 24-h age, a subgroup (n = 8) received up to four doses (0.5-1.0 mg/kg each) of hydrocortisone for refractory hypotension.'?","Yes, it is indirectly supported because hydrocortisone is being used to treat refractory hypotension in this subgroup of patients, implying its use in treating hypotensive disorders." +9175521,Hydrocortisone treats type 1 diabetes mellitus,1219,"Interaction of endogenous growth hormone, cortisol, and catecholamines with blood glucose in children with brittle diabetes mellitus.",False,"Is the triple 'Hydrocortisone treats type 1 diabetes mellitus' supported by the sentence: 'Interaction of endogenous growth hormone, cortisol, and catecholamines with blood glucose in children with brittle diabetes mellitus.'?","No, it is not directly supported because Hydrocortisone is a form of cortisol, but the statement discusses the interaction of endogenous cortisol, not Hydrocortisone specifically, with blood glucose in children with brittle diabetes mellitus, not necessarily type 1." +8776300,Hydrocortisone treats Inflammation,1220,"Acidification with a topical solution of 2 percent acetic acid combined with hydrocortisone for inflammation is effective treatment in most cases and, when used after exposure to moisture, is an excellent prophylactic.",True,"Is the triple 'Hydrocortisone treats Inflammation' supported by the sentence: 'Acidification with a topical solution of 2 percent acetic acid combined with hydrocortisone for inflammation is effective treatment in most cases and, when used after exposure to moisture, is an excellent prophylactic.'?","Yes, it is indirectly supported because it suggests that hydrocortisone can be used to treat inflammation, which aligns with the statement that hydrocortisone treats inflammation. However, it does not explicitly state that hydrocortisone alone treats inflammation, as acidification is also mentioned in the sentence." +8632826,Hydrocortisone treats bronchopulmonary dysplasia,1221,"To study a possible relation between the use of postnatal glucocorticoids and the incidence and severity of retinopathy of prematurity (ROP), we conducted a retrospective study over a 4-year period that compared data of 161 preterm infants treated with hydrocortisone for bronchopulmonary dysplasia (BPD) with the data of 253 controls.",True,"Is the triple 'Hydrocortisone treats bronchopulmonary dysplasia' supported by the sentence: 'To study a possible relation between the use of postnatal glucocorticoids and the incidence and severity of retinopathy of prematurity (ROP), we conducted a retrospective study over a 4-year period that compared data of 161 preterm infants treated with hydrocortisone for bronchopulmonary dysplasia (BPD) with the data of 253 controls.'?","Yes, it is indirectly supported because the provided sentence mentions that hydrocortisone was used to treat bronchopulmonary dysplasia (BPD) in preterm infants, which implies that hydrocortisone may have an effect on BPD. However, it does not directly mention that hydrocortisone treats BPD, nor does it mention anything about bronchopulmonary dysplasia being related to hydrocortisone use and incidence or severity of retinopathy of prematurity (ROP)." +8540090,"Hydrocortisone treats dermatitis, atopic",1222,Topical treatment with urea-hydrocortisone in atopic dermatitis.,True,"Is the triple 'Hydrocortisone treats dermatitis, atopic' supported by the sentence: 'Topical treatment with urea-hydrocortisone in atopic dermatitis.'?","Yes, it is indirectly supported because hydrocortisone is a component of urea-hydrocortisone and it is being used in a topical treatment for atopic dermatitis in this scenario." +8412499,Hydrocortisone treats obesity disorder,1223,"We studied the interactions of leptin, insulin and cortisol in obese children and adolescents at different stages of maturation.",False,"Is the triple 'Hydrocortisone treats obesity disorder' supported by the sentence: 'We studied the interactions of leptin, insulin and cortisol in obese children and adolescents at different stages of maturation.'?","No, this statement does not provide direct or indirect support for the claim that Hydrocortisone treats obesity disorder. The study mentioned is about the interactions of leptin, insulin, and cortisol in obese children and adolescents, not about Hydrocortisone as a treatment for obesity disorder." +8248241,Hydrocortisone treats Sepsis,1224,[Cortisol in critically ill patients with sepsis: physiologic functions and therapeutic implications].,True,Is the triple 'Hydrocortisone treats Sepsis' supported by the sentence: '[Cortisol in critically ill patients with sepsis: physiologic functions and therapeutic implications].'?,"Yes, it is indirectly supported. The article title suggests that it discusses cortisol, which is a hormone that the body produces in response to stress, including sepsis. Hydrocortisone is a synthetic form of this hormone often used in medical treatments. Therefore, it can be inferred that hydrocortisone could be used to treat sepsis by supplementing the body's own cortisol production. However, for a direct support, the article would need to explicitly mention hydrocortisone as a treatment for sepsis." +8061437,Hydrocortisone treats congenital adrenal hyperplasia,1225,"We conclude that the regimen of flutamide, testolactone, reduced hydrocortisone dose, and fludrocortisone provides effective control of congenital adrenal hyperplasia with reduced risk of glucocorticoid excess.",True,"Is the triple 'Hydrocortisone treats congenital adrenal hyperplasia' supported by the sentence: 'We conclude that the regimen of flutamide, testolactone, reduced hydrocortisone dose, and fludrocortisone provides effective control of congenital adrenal hyperplasia with reduced risk of glucocorticoid excess.'?","Yes, it is indirectly supported. The sentence mentions a regimen for controlling congenital adrenal hyperplasia, which includes a reduced dose of hydrocortisone. This suggests that hydrocortisone is indeed used in the treatment of this condition, which aligns with the statement that hydrocortisone treats congenital adrenal hyperplasia. However, it's important to note that the effectiveness of hydrocortisone in this context is attributed to a reduced dose as part of a larger treatment regimen, not necessarily to hydrocortisone alone." +8054429,Hydrocortisone treats borderline personality disorder,1226,RESULTS: The cortisol and prolactin responses to the m-CPP challenge in BPD patients were significantly lower compared to those in controls.,False,Is the triple 'Hydrocortisone treats borderline personality disorder' supported by the sentence: 'RESULTS: The cortisol and prolactin responses to the m-CPP challenge in BPD patients were significantly lower compared to those in controls.'?,"No, it is not directly or indirectly supported. Hydrocortisone is a synthetic glucocorticoid used primarily for its anti-inflammatory effects, not for treating borderline personality disorder (BPD). The study you mention seems to be investigating cortisol responses in BPD patients, not the effects of hydrocortisone treatment." +7996696,Hydrocortisone treats toxic shock syndrome,1227,Two recent small randomized trials evaluating a 5- to 12-day course of low dose hydrocortisone in patients with septic shock have reported a significant clinical improvement and a reduction in mortality.,True,Is the triple 'Hydrocortisone treats toxic shock syndrome' supported by the sentence: 'Two recent small randomized trials evaluating a 5- to 12-day course of low dose hydrocortisone in patients with septic shock have reported a significant clinical improvement and a reduction in mortality.'?,"Yes, it is indirectly supported. The mentioned studies suggest that hydrocortisone can improve clinical condition and reduce mortality in patients with septic shock, which is similar to symptoms observed in toxic shock syndrome (TSS). However, it's important to note that TSS is not explicitly mentioned in these studies, so this is an indirect inference based on similarities between sepsis and TSS symptoms, as well as the potential immunomodulatory effects of hydrocortisone in critical illnesses like sepsis and TSS." +7882717,Hydrocortisone treats castration-resistant prostate carcinoma,1228,"We have studied intravenous docetaxel 70 mg/m2, oral estramustine, and low-dose daily hydrocortisone in men with HRPC who demonstrated progression after initial hormone therapy.",True,"Is the triple 'Hydrocortisone treats castration-resistant prostate carcinoma' supported by the sentence: 'We have studied intravenous docetaxel 70 mg/m2, oral estramustine, and low-dose daily hydrocortisone in men with HRPC who demonstrated progression after initial hormone therapy.'?","Yes, it is indirectly supported because the use of low-dose daily hydrocortisone is mentioned in men with hormone-refractory prostate cancer (HRPC), which is a type of castration-resistant prostate cancer, after initial hormone therapy. However, it does not explicitly state that hydrocortisone treats this type of cancer, but rather it is used in its treatment regimen." +7698304,Hydrocortisone treats otitis externa,1229,"Results of clinical trials indicate that ofloxacin otic solution 0.3% is as effective as topical neomycin/polymixin B/hydrocortisone preparations in the treatment of otitis externa (clinical cure rate >80% in adults and >95% in children for both treatments) and oral amoxicillin/clavulanic acid in the treatment of otitis media in the presence of tympanostomy tubes in children (clinical cure rates 76 and 69% for ofloxacin and amoxicillin/clavulanic acid, respectively).",True,"Is the triple 'Hydrocortisone treats otitis externa' supported by the sentence: 'Results of clinical trials indicate that ofloxacin otic solution 0.3% is as effective as topical neomycin/polymixin B/hydrocortisone preparations in the treatment of otitis externa (clinical cure rate >80% in adults and >95% in children for both treatments) and oral amoxicillin/clavulanic acid in the treatment of otitis media in the presence of tympanostomy tubes in children (clinical cure rates 76 and 69% for ofloxacin and amoxicillin/clavulanic acid, respectively).'?","Yes, it is indirectly supported because hydrocortisone is mentioned as part of a topical preparation for treating otitis externa, which was found to be as effective as ofloxacin otic solution in a clinical trial, as stated in your provided text." +7584436,Hydrocortisone treats Crohn disease,1230,CONCLUSIONS: The observed increase in albumin binding might limit the bioactivity of cortisol in patients with Crohn's disease and contribute to the decreased effectiveness and weaker side effects of glucocorticoid therapy in these patients.,True,Is the triple 'Hydrocortisone treats Crohn disease' supported by the sentence: 'CONCLUSIONS: The observed increase in albumin binding might limit the bioactivity of cortisol in patients with Crohn's disease and contribute to the decreased effectiveness and weaker side effects of glucocorticoid therapy in these patients.'?,"Yes, it is indirectly supported because it suggests that cortisol's bioactivity may be limited in patients with Crohn's disease, which could potentially make treatments like Hydrocortisone less effective, given that Hydrocortisone is a synthetic form of cortisol, a glucocorticoid hormone. However, it does not directly state that Hydrocortisone specifically is used to treat Crohn's disease, just that glucocorticoid therapy may be less effective due to decreased bioactivity of cortisol." +7432481,Hydrocortisone treats pancreatitis,1231,"The amount of N-acetyl D-glucosamine in the zymogen granule membrane was not altered by caerulein acute pancreatitis induced under continuous hydrocortisone treatment, but it was decreased by the administration of L-364,718 over 7 days after pancreatitis induction.",False,"Is the triple 'Hydrocortisone treats pancreatitis' supported by the sentence: 'The amount of N-acetyl D-glucosamine in the zymogen granule membrane was not altered by caerulein acute pancreatitis induced under continuous hydrocortisone treatment, but it was decreased by the administration of L-364,718 over 7 days after pancreatitis induction.'?","No, it is not directly or indirectly supported, as there is no mention in this statement about Hydrocortisone treating pancreatitis, but rather about its effect on certain membrane components during a specific type of pancreatitis induction." +7402054,Hydrocortisone treats fibromyalgia,1232,Graded ACTH infusion revealed similar increases in cortisol in women with fibromyalgia and healthy controls.,True,Is the triple 'Hydrocortisone treats fibromyalgia' supported by the sentence: 'Graded ACTH infusion revealed similar increases in cortisol in women with fibromyalgia and healthy controls.'?,"Yes, it is indirectly supported. The presence of a similar increase in cortisol levels in women with fibromyalgia and healthy controls in response to a graded ACTH infusion suggests that hydrocortisone, a synthetic form of cortisol, could potentially have a similar effect on both groups. However, this does not directly imply that hydrocortisone is a treatment for fibromyalgia, as further research would be needed to establish this." +7378370,Hydrocortisone treats chronic primary adrenal insufficiency,1233,The effects of endogenous opioids and cortisol on thyrotropin and prolactin secretion in patients with Addison's disease.,True,Is the triple 'Hydrocortisone treats chronic primary adrenal insufficiency' supported by the sentence: 'The effects of endogenous opioids and cortisol on thyrotropin and prolactin secretion in patients with Addison's disease.'?,"Yes, it is indirectly supported because Hydrocortisone is a synthetic form of cortisol, which is mentioned in the sentence, and it is used to treat chronic primary adrenal insufficiency, which is another term for Addison's disease, as mentioned in the sentence. However, the sentence does not directly mention Hydrocortisone, hence it is an indirect support." +7363431,Hydrocortisone treats asthma,1234,[Dynamics of the cortisol content in the blood plasma in specific hyposensibilization in children with bronchial asthma].,True,Is the triple 'Hydrocortisone treats asthma' supported by the sentence: '[Dynamics of the cortisol content in the blood plasma in specific hyposensibilization in children with bronchial asthma].'?,"Yes, it is indirectly supported because Hydrocortisone is a type of corticosteroid, which can affect cortisol levels in the body, and the study mentioned is about changes in cortisol levels (a stress hormone) during a specific treatment for bronchial asthma, a condition that Hydrocortisone is often used to treat. However, it's important to note that this is a very indirect connection, as it doesn't directly mention Hydrocortisone treating asthma, but rather discusses changes in cortisol levels during a specific treatment for asthma." +27127545,Methylprednisolone treats lymphoproliferative syndrome,1235,Treatment of X-linked lymphoproliferative disease (Duncan disease) with high-dose methylprednisolone and etoposide (VP-16).,True,Is the triple 'Methylprednisolone treats lymphoproliferative syndrome' supported by the sentence: 'Treatment of X-linked lymphoproliferative disease (Duncan disease) with high-dose methylprednisolone and etoposide (VP-16).'?,"Yes, it is indirectly supported because both sentences mention methylprednisolone as a treatment for a type of disease that involves abnormal proliferation of lymphocytes, although they refer to different specific conditions (X-linked lymphoproliferative disease in the second sentence)." +26450412,Methylprednisolone treats leukemia,1236,"Circadian optimization of the treatment of L1210 leukemia with 1-beta-D-arabinofuranosylcytosine, cyclophosphamide, vincristine and methylprednisolone.",False,"Is the triple 'Methylprednisolone treats leukemia' supported by the sentence: 'Circadian optimization of the treatment of L1210 leukemia with 1-beta-D-arabinofuranosylcytosine, cyclophosphamide, vincristine and methylprednisolone.'?","No, this statement does not provide direct support for the claim that Methylprednisolone treats leukemia. It mentions Methylprednisolone as part of a larger treatment regimen for L1210 leukemia, but it does not confirm that Methylprednisolone alone is effective in treating this type of cancer." +26339812,Methylprednisolone treats alcoholic hepatitis,1237,Controlled trial of methylprednisolone therapy in severe acute alcoholic hepatitis.,True,Is the triple 'Methylprednisolone treats alcoholic hepatitis' supported by the sentence: 'Controlled trial of methylprednisolone therapy in severe acute alcoholic hepatitis.'?,"Yes, it is indirectly supported, as it suggests that a controlled trial was conducted to test the efficacy of Methylprednisolone in treating severe acute alcoholic hepatitis, implying a potential positive effect. However, it does not confirm that Methylprednisolone directly treats alcoholic hepatitis, as further research, data, and context would be required to make that conclusion." +26307075,Methylprednisolone treats psoriatic arthritis,1238,"1 The present study was undertaken to characterize the spectrum of arachidonic acid metabolites present in synovial effusions of patients with rheumatoid or psoriatic arthritis, and to compare changes in their concentration following a short-term treatment with 6alpha-methyl-prednisolone (6-MeP: 4-8 mg/day) or indoprofen (1.2 g/day), a nonsteroidal anti-inflammatory agent with proven synovial prostaglandin inhibitory effect.2 Measurements of prostaglandin E(2) (PGE(2)), thromboxane (TX) B(2), 6-keto-PGF(1alpha) and PGF(2alpha) were performed by radioimmunoassay techniques in synovial effusions obtained from 23 patients, and validated by thin-layer chromatographic analysis of the extracted immunoreactivity.3 PGE(2) and TXB(2) accounted for more than 60% of the total immunoreactivity in untreated patients.",False,"Is the triple 'Methylprednisolone treats psoriatic arthritis' supported by the sentence: '1 The present study was undertaken to characterize the spectrum of arachidonic acid metabolites present in synovial effusions of patients with rheumatoid or psoriatic arthritis, and to compare changes in their concentration following a short-term treatment with 6alpha-methyl-prednisolone (6-MeP: 4-8 mg/day) or indoprofen (1.2 g/day), a nonsteroidal anti-inflammatory agent with proven synovial prostaglandin inhibitory effect.2 Measurements of prostaglandin E(2) (PGE(2)), thromboxane (TX) B(2), 6-keto-PGF(1alpha) and PGF(2alpha) were performed by radioimmunoassay techniques in synovial effusions obtained from 23 patients, and validated by thin-layer chromatographic analysis of the extracted immunoreactivity.3 PGE(2) and TXB(2) accounted for more than 60% of the total immunoreactivity in untreated patients.'?","No, this statement does not provide direct evidence that Methylprednisolone treats psoriatic arthritis. It does, however, suggest that Methylprednisolone may have an effect on the metabolites of arachidonic acid, which are associated with inflammation in rheumatoid and psoriatic arthritis. But it does not confirm that it can treat psoriatic arthritis." +26279366,Methylprednisolone treats angioimmunoblastic T-cell lymphoma,1239,Pulse methylprednisolone therapy in angioimmunoblastic lymphadenopathy.,True,Is the triple 'Methylprednisolone treats angioimmunoblastic T-cell lymphoma' supported by the sentence: 'Pulse methylprednisolone therapy in angioimmunoblastic lymphadenopathy.'?,"Yes, the statement ""Pulse methylprednisolone therapy in angioimmunoblastic lymphadenopathy."" does provide some level of support for the idea that Methylprednisolone can be used to treat angioimmunoblastic T-cell lymphoma, given that angioimmunoblastic lymphadenopathy is a symptom often associated with this type of lymphoma. However, it's important to note that this is an indirect support, as it doesn't specifically mention the type of lymphoma, but rather a symptom that can be present in it. For a more direct support, a statement specifically mentioning the use of Methylprednisolone in treating angioimmunoblastic T-cell lymphoma would be needed." +25738014,Methylprednisolone treats ankylosing spondylitis,1240,Seven patients with active AS and insufficient efficacy of NSAID for three months were treated with one gram methylprednisolone daily given intravenously for three successive days.,True,Is the triple 'Methylprednisolone treats ankylosing spondylitis' supported by the sentence: 'Seven patients with active AS and insufficient efficacy of NSAID for three months were treated with one gram methylprednisolone daily given intravenously for three successive days.'?,"Yes, it is indirectly supported, as it mentions treatment of active Ankylosing Spondylitis (AS) using Methylprednisolone, which is a type of corticosteroid used to reduce inflammation in various diseases, including AS. However, it does not directly state that Methylprednisolone is a primary treatment for AS, nor that it is more effective than other treatments, such as NSAIDs (Nonsteroidal Anti-Inflammatory Drugs)." +25734987,Methylprednisolone treats non-Hodgkin lymphoma,1241,"Peptichemio, a new oncolytic drug with alkylating and antimetabolic properties was employed in combination with vincristine and 6-methylprednisolone (PVP) for the treatment of diffuse non-Hodgkin's lymphomas (NHL), stages III and IV.",True,"Is the triple 'Methylprednisolone treats non-Hodgkin lymphoma' supported by the sentence: 'Peptichemio, a new oncolytic drug with alkylating and antimetabolic properties was employed in combination with vincristine and 6-methylprednisolone (PVP) for the treatment of diffuse non-Hodgkin's lymphomas (NHL), stages III and IV.'?","Yes, it is indirectly supported because methylprednisolone is mentioned in combination with other drugs for treating diffuse non-Hodgkin's lymphomas, but it does not specify whether methylprednisolone alone has any effect on non-Hodgkin lymphoma." +25642231,Methylprednisolone treats heart disorder,1242,High-dose MP may be contraindicated in patients with known heart disease.,True,Is the triple 'Methylprednisolone treats heart disorder' supported by the sentence: 'High-dose MP may be contraindicated in patients with known heart disease.'?,"Yes, it is indirectly supported. The statement ""High-dose MP may be contraindicated in patients with known heart disease"" suggests that Methylprednisolone (MP) could have potential negative effects on patients with heart disease, which implies that it might not be an effective treatment for heart disorders." +25366540,Methylprednisolone treats myopathy,1243,PURPOSE: To report the therapeutic efficacy of intravenous methylprednisolone (IVMP) in patients with restrictive myopathy caused by thyroid eye disease (TED).,True,Is the triple 'Methylprednisolone treats myopathy' supported by the sentence: 'PURPOSE: To report the therapeutic efficacy of intravenous methylprednisolone (IVMP) in patients with restrictive myopathy caused by thyroid eye disease (TED).'?,"Yes, it is indirectly supported because it mentions that methylprednisolone is used in treating a form of myopathy (restrictive myopathy caused by TED) and shows a potential positive effect (therapeutic efficacy)." +24273559,Methylprednisolone treats Abdominal pain,1244,"After 2 months of treatment with systemic methylprednisolone, cyclophosphamide, and prednisone, the patient's abdominal pain was relieved.",True,"Is the triple 'Methylprednisolone treats Abdominal pain' supported by the sentence: 'After 2 months of treatment with systemic methylprednisolone, cyclophosphamide, and prednisone, the patient's abdominal pain was relieved.'?","Yes, this is indirectly supported, as abdominal pain was relieved after a regimen that included methylprednisolone, although it's important to note that other treatments were also administered concurrently, making it impossible to attribute the relief solely to methylprednisolone." +23772707,Methylprednisolone treats cardiac arrest,1245,Effect of Vasopressin and Methylprednisolone vs Placebo on Return of Spontaneous Circulation in Patients With In-Hospital Cardiac Arrest: A Randomized Clinical Trial.,True,Is the triple 'Methylprednisolone treats cardiac arrest' supported by the sentence: 'Effect of Vasopressin and Methylprednisolone vs Placebo on Return of Spontaneous Circulation in Patients With In-Hospital Cardiac Arrest: A Randomized Clinical Trial.'?,"Yes, it is indirectly supported because the study mentioned in your question investigates the effect of methylprednisolone on in-hospital cardiac arrest, suggesting a potential connection to treating such a condition. However, it does not explicitly state that methylprednisolone is used to treat cardiac arrest directly, but rather as a part of a treatment regimen that includes vasopressin for in-Hospital Cardiac Arrest patients, which may have implications for treating cardiac arrest symptoms or complications." +23209303,Methylprednisolone treats respiratory system disorder,1246,"Although methylprednisolone gradually improved her respiratory condition, her oxygenation and exercise tolerance had drastically deteriorated, necessitating high-flow nasal cannula oxygen therapy.",True,"Is the triple 'Methylprednisolone treats respiratory system disorder' supported by the sentence: 'Although methylprednisolone gradually improved her respiratory condition, her oxygenation and exercise tolerance had drastically deteriorated, necessitating high-flow nasal cannula oxygen therapy.'?","Yes, it is indirectly supported because methylprednisolone did improve her respiratory condition, but it did not prevent the need for high-flow nasal cannula oxygen therapy due to her deteriorated oxygenation and exercise tolerance." +23116362,Methylprednisolone treats pneumocystosis,1247,"Caspofungin, TMP-SMX, clindamycin and MP were used to treat P. jirovecii pneumonia (PJP).",True,"Is the triple 'Methylprednisolone treats pneumocystosis' supported by the sentence: 'Caspofungin, TMP-SMX, clindamycin and MP were used to treat P. jirovecii pneumonia (PJP).'?","Yes, the statement does support it indirectly. Methylprednisolone (MP) is mentioned as one of the drugs used to treat P. jirovecii (PJP) pneumonia, which is a form of pneumonia caused by Pneumocystis jirovecii. However, it's important to note that MP is often used to manage the inflammatory response associated with PJP rather than treating the infection itself." +22495912,Methylprednisolone treats myocarditis,1248,"Although, not described in the literature, we have found conjunctive use of milrinone and methylprednisolone effective in patient with SARS-CoV-2 fulminant myocarditis.",True,"Is the triple 'Methylprednisolone treats myocarditis' supported by the sentence: 'Although, not described in the literature, we have found conjunctive use of milrinone and methylprednisolone effective in patient with SARS-CoV-2 fulminant myocarditis.'?","Yes, it is indirectly supported because both sentences discuss the treatment of myocarditis with methylprednisolone, although in combination with different drugs (milrinone instead of Methylprednisolone)." +19962298,Methylprednisolone treats Hodgkins lymphoma,1249,High incidence of aseptic hip necrosis in Hodgkin lymphoma patients treated with escalated BEACOPP receiving methylprednisolone.,True,Is the triple 'Methylprednisolone treats Hodgkins lymphoma' supported by the sentence: 'High incidence of aseptic hip necrosis in Hodgkin lymphoma patients treated with escalated BEACOPP receiving methylprednisolone.'?,"Yes, it is indirectly supported because it mentions methylprednisolone being used in treatment for patients with Hodgkin Lymphoma, which implies that methylprednisolone is a potential treatment for this type of cancer, even though it doesn't explicitly state that it treats Hodgkin Lymphoma directly." +19674675,Methylprednisolone treats microscopic polyangiitis,1250,Six newly diagnosed patients with MPA were initially treated with methylprednisolone and a single dose of RTX (375 mg/m2).,True,Is the triple 'Methylprednisolone treats microscopic polyangiitis' supported by the sentence: 'Six newly diagnosed patients with MPA were initially treated with methylprednisolone and a single dose of RTX (375 mg/m2).'?,"Yes, it is indirectly supported. The statement mentions that six new MPA patients were treated with methylprednisolone, implying that methylprednisolone is used in the treatment of MPA, which aligns with the claim that it treats microscopic polyangiitis (MPA). However, it does not directly state that methylprednisolone alone treats MPA, as it is used in conjunction with RTX in this specific scenario." +19534575,Methylprednisolone treats anterior ischemic optic neuropathy,1251,Early Methylprednisolone Treatment Can Stabilize the Blood-Optic Nerve Barrier in a Rat Model of Anterior Ischemic Optic Neuropathy (rAION).,True,Is the triple 'Methylprednisolone treats anterior ischemic optic neuropathy' supported by the sentence: 'Early Methylprednisolone Treatment Can Stabilize the Blood-Optic Nerve Barrier in a Rat Model of Anterior Ischemic Optic Neuropathy (rAION).'?,"Yes, it can be interpreted as indirect support, as stabilization of the blood-optic nerve barrier could potentially help in treating anterior ischemic optic neuropathy (AION). However, it doesn't directly state that Methylprednisolone treats AION, but rather that it can stabilize the blood-optic nerve barrier in a rat model of AION." +18427985,Methylprednisolone treats osteoarthritis,1252,"We report a case of a 68-year-old woman who presented with severe abdominal pain, nausea and vomiting, 3 days after the initiation of low-dose methylprednisolone for osteoarthritis.",True,"Is the triple 'Methylprednisolone treats osteoarthritis' supported by the sentence: 'We report a case of a 68-year-old woman who presented with severe abdominal pain, nausea and vomiting, 3 days after the initiation of low-dose methylprednisolone for osteoarthritis.'?","Yes, it is indirectly supported because it mentions that methylprednisolone was initiated for osteoarthritis, but it does not directly state that methylprednisolone is effective in treating osteoarthritis, nor does it mention any adverse effects related to osteoarthritis that were alleviated by methylprednisolone." +18276332,Methylprednisolone treats plantar fasciitis,1253,OBJECTIVES: To compare the effectiveness of oral nonsteroidal antiinflammatory drugs (NSAIDs) and locally injectable steroid (methylprednisolone) in the treatment of plantar fasciitis.,True,Is the triple 'Methylprednisolone treats plantar fasciitis' supported by the sentence: 'OBJECTIVES: To compare the effectiveness of oral nonsteroidal antiinflammatory drugs (NSAIDs) and locally injectable steroid (methylprednisolone) in the treatment of plantar fasciitis.'?,"Yes, it is indirectly supported because the sentence mentions methylprednisolone as a locally injectable steroid used in the treatment of plantar fasciitis, which implies that it is a therapeutic option for this condition, although it does not explicitly state that it treats plantar fasciitis directly." +18008318,Methylprednisolone treats dermatomyositis,1254,A Japanese woman was treated with injectable methylprednisolone and oral prednisolone for dermatomyositis.,True,Is the triple 'Methylprednisolone treats dermatomyositis' supported by the sentence: 'A Japanese woman was treated with injectable methylprednisolone and oral prednisolone for dermatomyositis.'?,"Yes, it is indirectly supported, as both methylprednisolone (injectable) and prednisolone (oral) belong to a class of drugs called corticosteroids, which are commonly used to treat inflammatory conditions like dermatomyositis. However, it does not specifically mention that methylprednisolone alone is effective in treating dermatomyositis, which is what the original statement implies." +17478785,Methylprednisolone treats nasal cavity polyp,1255,"The study by Van Zele et al reports positive results for a randomized, double-blind, placebo-controlled trial that used either 20 days of doxycycline (200 mg the first day, followed by 100 mg daily) or 20 days of a tapering schedule of methyl prednisolone (32 mg on days 1-5, 16 mg on days 6-10, and 8 mg on days 11-20) for the treatment of nasal polyps.",True,"Is the triple 'Methylprednisolone treats nasal cavity polyp' supported by the sentence: 'The study by Van Zele et al reports positive results for a randomized, double-blind, placebo-controlled trial that used either 20 days of doxycycline (200 mg the first day, followed by 100 mg daily) or 20 days of a tapering schedule of methyl prednisolone (32 mg on days 1-5, 16 mg on days 6-10, and 8 mg on days 11-20) for the treatment of nasal polyps.'?","Yes, the statement is indirectly supported because it mentions that a tapering schedule of methyl prednisolone was used in a trial for treating nasal polyps, but it does not explicitly state that methylprednisolone is effective for treating nasal cavity polyps." +15407991,Methylprednisolone treats radiculopathy,1256,"Herein, we present our experience of management of such cases with a single epidural injection of local anaesthetic, tramadol and methylprednisolone, and table tilt for management of both radiculopathies.",True,"Is the triple 'Methylprednisolone treats radiculopathy' supported by the sentence: 'Herein, we present our experience of management of such cases with a single epidural injection of local anaesthetic, tramadol and methylprednisolone, and table tilt for management of both radiculopathies.'?","Yes, it is indirectly supported. The sentence mentions methylprednisolone being used in an epidural injection to manage radiculopathies, which aligns with the statement that methylprednisolone can be used to treat radiculopathy." +14897628,Methylprednisolone treats neuromyelitis optica,1257,Early high-dose intravenous methylprednisolone is effective in preserving retinal nerve fiber layer thickness in patients with neuromyelitis optica.,True,Is the triple 'Methylprednisolone treats neuromyelitis optica' supported by the sentence: 'Early high-dose intravenous methylprednisolone is effective in preserving retinal nerve fiber layer thickness in patients with neuromyelitis optica.'?,"Yes, it is indirectly supported because methylprednisolone is being used to treat neuromyelitis optica in this study, which could potentially have a positive effect on other areas affected by the condition, such as the optic nerve. However, it's important to note that this study is specifically looking at the effect on retinal nerve fiber layer thickness, not necessarily the overall treatment of neuromyelitis optica." +14825096,Methylprednisolone treats West syndrome,1258,The authors report their experience with intravenous methylprednisolone for the treatment of infantile spasms.,True,Is the triple 'Methylprednisolone treats West syndrome' supported by the sentence: 'The authors report their experience with intravenous methylprednisolone for the treatment of infantile spasms.'?,"Yes, it is indirectly supported, as both statements mention Methylprednisolone being used for treatment, but they do not explicitly state that it is used for treating West Syndrome in this particular case mentioned in this specific sentence." +14690661,Methylprednisolone treats Meniere disease,1259,OBJECTIVE: To describe the long-term efficacy of transtympanic steroids (TTS) using methyl-prednisolone in the treatment of Meniere's disease (MD).,True,Is the triple 'Methylprednisolone treats Meniere disease' supported by the sentence: 'OBJECTIVE: To describe the long-term efficacy of transtympanic steroids (TTS) using methyl-prednisolone in the treatment of Meniere's disease (MD).'?,"Yes, it is indirectly supported, as the provided objective suggests a study on using methylprednisolone in transtympanic steroids for treating Meniere's disease, which implies methylprednisolone's potential role in managing this condition. However, it does not directly confirm that methylprednisolone alone is an effective treatment for Meniere's disease, but rather as a component of transtympanic steroids therapy." +14636779,Methylprednisolone treats neoplasm,1260,"Rats with stereotactically implanted Walker 256 tumors were treated with methylprednisolone, U-74006F, U-78517F, or vehicle (0.05 N HCl) on Days 6 through 10 following implantation.",False,"Is the triple 'Methylprednisolone treats neoplasm' supported by the sentence: 'Rats with stereotactically implanted Walker 256 tumors were treated with methylprednisolone, U-74006F, U-78517F, or vehicle (0.05 N HCl) on Days 6 through 10 following implantation.'?","No, this statement does not support that methylprednisolone treats neoplasms (tumors). The text describes an experiment where rats with tumors were treated with various substances, including methylprednisolone, but it does not provide information on the outcomes of these treatments or whether methylprednisolone specifically was effective in treating the tumors (neoplasms)." +14398238,Methylprednisolone treats IgA glomerulonephritis,1261,"CONCLUSIONS: Methylprednisolone and cyclophosphamide in children with Grade IV IgA nephropathy stabilized renal function and significantly reduced hematuria, proteinuria, mesangial IgA deposition, and the renal pathological activity index.",True,"Is the triple 'Methylprednisolone treats IgA glomerulonephritis' supported by the sentence: 'CONCLUSIONS: Methylprednisolone and cyclophosphamide in children with Grade IV IgA nephropathy stabilized renal function and significantly reduced hematuria, proteinuria, mesangial IgA deposition, and the renal pathological activity index.'?","Yes, it is indirectly supported, as it mentions that Methylprednisolone reduces mesangial IgA deposition, which is a characteristic of IgA nephropathy, but it doesn't explicitly state that it treats IgA glomerulonephritis (IgAN)." +14232595,Methylprednisolone treats membranous glomerulonephritis,1262,"MN was treated with methylprednisolone as first-line therapy, then she was changed to rituximab for a relapse.",True,"Is the triple 'Methylprednisolone treats membranous glomerulonephritis' supported by the sentence: 'MN was treated with methylprednisolone as first-line therapy, then she was changed to rituximab for a relapse.'?","Yes, it is indirectly supported. The sentence suggests that methylprednisolone was used as a first-line treatment for membranous glomerulonephritis (MN), which implies that it has some therapeutic effect on this condition. However, the patient had a relapse, which indicates that methylprednisolone may not be sufficient as a long-term treatment for all cases of MN, hence the need for additional therapy (in this case, rituximab)." +14027935,Methylprednisolone treats diffuse large B-cell lymphoma,1263,"This study evaluated the influence of prior exposure to rituximab on response rates and survival in patients with diffuse large B-cell lymphoma treated with rituximab plus etoposide, cytarabine, cisplatinum and methylprednisolone (R-ESHAP).",False,"Is the triple 'Methylprednisolone treats diffuse large B-cell lymphoma' supported by the sentence: 'This study evaluated the influence of prior exposure to rituximab on response rates and survival in patients with diffuse large B-cell lymphoma treated with rituximab plus etoposide, cytarabine, cisplatinum and methylprednisolone (R-ESHAP).'?","No, this statement does not directly support that Methylprednisolone treats diffuse large B-cell lymphoma. It only mentions that Methylprednisolone is used in a treatment regimen for patients with diffuse large B-cell lymphoma, but it does not state that Methylprednisolone is responsible for treating the disease itself." +13679356,Methylprednisolone treats hemophagocytic syndrome,1264,"A 46 year old woman who presented with severe multiorgans involvement including liver brain, cardio-pulmonary failure, gastrointestinal bleeding, progressive cytopenia, DIC and hemophagocytic syndrome during the convalescent phase of Dengue type II has been successfully treated primarily with pulse methyl prednisolone and high dose intravenous immunoglobulin G.",True,"Is the triple 'Methylprednisolone treats hemophagocytic syndrome' supported by the sentence: 'A 46 year old woman who presented with severe multiorgans involvement including liver brain, cardio-pulmonary failure, gastrointestinal bleeding, progressive cytopenia, DIC and hemophagocytic syndrome during the convalescent phase of Dengue type II has been successfully treated primarily with pulse methyl prednisolone and high dose intravenous immunoglobulin G.'?","Yes, the statement does provide some level of support for the idea that Methylprednisolone can be used to treat hemophaglocytic syndrome, as it describes a case where a patient with this condition was successfully treated with it. However, it's important to note that this is just one case, and further research would be needed to fully establish the effectiveness of this treatment." +13619118,Methylprednisolone treats chronic obstructive pulmonary disease,1265,"In conclusion, methylprednisolone in combination with conventional medical therapy not only improved lung function values but also mean nocturnal oxyhemoglobin saturation and sleep duration in clinically stabilized COPD patients who experience nocturnal oxyhemoglobin desaturation.",True,"Is the triple 'Methylprednisolone treats chronic obstructive pulmonary disease' supported by the sentence: 'In conclusion, methylprednisolone in combination with conventional medical therapy not only improved lung function values but also mean nocturnal oxyhemoglobin saturation and sleep duration in clinically stabilized COPD patients who experience nocturnal oxyhemoglobin desaturation.'?","Yes, the statement does provide some level of support for the idea that Methylprednisolone could potentially have a positive impact on Chronic Obstructive Pulmonary Disease (COPD). It suggests that Methylprednisolone, when used in combination with conventional medical therapy, can improve lung function values and mean nocturnal oxyhemoglobin saturation in clinically stabilized COPD patients who experience nocturnal oxyhemoglobin desaturation. However, it's important to note that this is an indirect support as it doesn't explicitly state that Methylprednisolone treats COPD, but rather it suggests a potential beneficial effect in managing certain symptoms in some COPD patients." +13533673,Methylprednisolone treats macrophage activation syndrome,1266,"Following treatment with etanercept, ibuprofen, methylprednisolone, and phenylbutazone for 3 weeks, MAS deteriorated and fatal cerebral edema occurred within only 24 h.",True,"Is the triple 'Methylprednisolone treats macrophage activation syndrome' supported by the sentence: 'Following treatment with etanercept, ibuprofen, methylprednisolone, and phenylbutazone for 3 weeks, MAS deteriorated and fatal cerebral edema occurred within only 24 h.'?","Yes, it is indirectly supported because MAS did not improve after methylprednisolone was administered, which suggests that methylprednisolone might not be effective in treating MAS in this particular case. However, this does not necessarily mean that methylprednisolone is not effective in treating MAS in general, as different cases may respond differently to treatments." +13161419,Methylprednisolone treats systemic sclerosis,1267,"CONCLUSION: The results of this pilot study suggest that the combination of MMF, IV MP and low-dose GC might achieve good clinical, functional and radiological results in patients suffering from severe early SSc.",True,"Is the triple 'Methylprednisolone treats systemic sclerosis' supported by the sentence: 'CONCLUSION: The results of this pilot study suggest that the combination of MMF, IV MP and low-dose GC might achieve good clinical, functional and radiological results in patients suffering from severe early SSc.'?","Yes, it is indirectly supported because it mentions that MMF (Mycophenolate Mofetil), IV MP (intravenous Methylprednisolone), and low-dose GC (glucocorticoids) might achieve good results in patients with severe early Systemic Sclerosis (SSc). However, it does not directly state that Methylprednisolone alone treats systemic sclerosis, but it does suggest its beneficial use in combination with other treatments." +13096165,Methylprednisolone treats optic nerve disorder,1268,"Dysthyroid optic neuropathy is best treated with intravenous pulsed methylprednisolone; if visual functions do not recover, urgent surgical decompression is indicated.",True,"Is the triple 'Methylprednisolone treats optic nerve disorder' supported by the sentence: 'Dysthyroid optic neuropathy is best treated with intravenous pulsed methylprednisolone; if visual functions do not recover, urgent surgical decompression is indicated.'?","Yes, it is supported. The given sentence suggests that intravenous pulsed methylprednisolone is used to treat dysthyroid optic neuropathy, which is an optic nerve disorder. Therefore, methylprednisolone is indeed used to treat an optic nerve disorder, thus providing support for the statement, albeit indirectly." +12975348,Methylprednisolone treats mature T-cell and NK-cell non-Hodgkin lymphoma,1269,"Gemcitabine, cisplatin and methylprednisolone for the treatment of patients with peripheral T-cell lymphoma: the Royal Marsden Hospital experience.",True,"Is the triple 'Methylprednisolone treats mature T-cell and NK-cell non-Hodgkin lymphoma' supported by the sentence: 'Gemcitabine, cisplatin and methylprednisolone for the treatment of patients with peripheral T-cell lymphoma: the Royal Marsden Hospital experience.'?","Yes, it is indirectly supported because Methylprednisolone is mentioned as part of a treatment regimen for peripheral T-cell lymphoma in the provided sentence, which is a type of non-Hodgkin lymphoma that involves mature T-cells and NK-cells. However, it does not specifically state that Methylprednisolone is used to treat these types of lymphomas, hence it's an indirect support." +12450216,Methylprednisolone treats bronchopulmonary dysplasia,1270,Hypertrophic cardiomyopathy in preterm infants treated with methylprednisolone for bronchopulmonary dysplasia.,False,Is the triple 'Methylprednisolone treats bronchopulmonary dysplasia' supported by the sentence: 'Hypertrophic cardiomyopathy in preterm infants treated with methylprednisolone for bronchopulmonary dysplasia.'?,"No, it is not directly supported because hypertrophic cardiomyopathy is not equivalent to bronchopulmonary dysplasia, although it is a potential side effect of treatment with methylprednisolone in preterm infants with bronchopulmonary dysplasia." +11895116,Methylprednisolone treats plasma cell myeloma,1271,Multiple myeloma of Stage IIa was diagnosed and she was given cytostatic therapy with 17.5 mg melphalan and 112 mg methylprednisolone daily by mouth (for 4 days at intervals of 6 weeks).,True,Is the triple 'Methylprednisolone treats plasma cell myeloma' supported by the sentence: 'Multiple myeloma of Stage IIa was diagnosed and she was given cytostatic therapy with 17.5 mg melphalan and 112 mg methylprednisolone daily by mouth (for 4 days at intervals of 6 weeks).'?,"Yes, the statement supports the idea that methylprednisolone is used in treating multiple myeloma, as it is mentioned in the cytostatic therapy given to a patient with this condition. However, it doesn't explicitly state that methylprednisolone is effective in treating plasma cell myeloma, so it's an indirect support at best." +11882768,Methylprednisolone treats Cognitive impairment,1272,One-year cyclophosphamide treatment combined with methylprednisolone improves cognitive dysfunction in progressive forms of multiple sclerosis.,True,Is the triple 'Methylprednisolone treats Cognitive impairment' supported by the sentence: 'One-year cyclophosphamide treatment combined with methylprednisolone improves cognitive dysfunction in progressive forms of multiple sclerosis.'?,"Yes, it is indirectly supported. The statement suggests that methylprednisolone, when used in combination with cyclophosphamide, can improve cognitive dysfunction in multiple sclerosis patients. This implies that methylprednisolone has some positive effect on cognitive function, even though it doesn't directly state that it treats cognitive impairment." +11547088,Methylprednisolone treats thrombotic thrombocytopenic purpura,1273,"The hematologic evaluations and her clinical course revealed the diagnosis of TTP, so plasma exchange and methyl-prednisolone therapy were initiated.",True,"Is the triple 'Methylprednisolone treats thrombotic thrombocytopenic purpura' supported by the sentence: 'The hematologic evaluations and her clinical course revealed the diagnosis of TTP, so plasma exchange and methyl-prednisolone therapy were initiated.'?","Yes, it is supported. The sentence mentions that methyl-prednisolone therapy was initiated after the diagnosis of TTP, which suggests that methylprednisolone was used to treat TTP, which aligns with the statement that methylprednisolone treats TTP, even if indirectly." +11313619,Methylprednisolone treats vestibular neuronitis,1274,"METHODS: We performed a prospective, randomized, double-blind, two-by-two factorial trial in which patients with acute vestibular neuritis were randomly assigned to treatment with placebo, methylprednisolone, valacyclovir, or methylprednisolone plus valacyclovir.",True,"Is the triple 'Methylprednisolone treats vestibular neuronitis' supported by the sentence: 'METHODS: We performed a prospective, randomized, double-blind, two-by-two factorial trial in which patients with acute vestibular neuritis were randomly assigned to treatment with placebo, methylprednisolone, valacyclovir, or methylprednisolone plus valacyclovir.'?","Yes, the statement is indirectly supported, as it shows that methylprednisolone is being used in a trial for acute vestibular neuritis, which implies that it is being considered as a treatment for this condition. However, it does not directly state that methylprednisolone treats vestibular neuronitis, but rather that it is being studied in relation to it." +10801960,Methylprednisolone treats B-cell chronic lymphocytic leukemia,1275,High dose methylprednisolone can induce remissions in CLL patients with p53 abnormalities.,True,Is the triple 'Methylprednisolone treats B-cell chronic lymphocytic leukemia' supported by the sentence: 'High dose methylprednisolone can induce remissions in CLL patients with p53 abnormalities.'?,"Yes, it is indirectly supported. The given sentence suggests that high dose methylprednisolone can have an effect on B-cell chronic lymphocytic leukemia (CLL) patients with p53 abnormalities, which implies that methylprednisolone could potentially be used in treating this type of leukemia, albeit not directly stating that it is a primary treatment for B-cell chronic lymphocytic leukemia." +10634179,Methylprednisolone treats Crohn disease,1276,An example of acute pancreatitis developing five weeks after initial treatment with 5-aminosalicylic acid (5-ASA) and methylprednisolone for severe Crohn's disease is reported in a 37 year old female patient.,True,Is the triple 'Methylprednisolone treats Crohn disease' supported by the sentence: 'An example of acute pancreatitis developing five weeks after initial treatment with 5-aminosalicylic acid (5-ASA) and methylprednisolone for severe Crohn's disease is reported in a 37 year old female patient.'?,"Yes, it is indirectly supported, as it mentions methylprednisolone being used in treatment for severe Crohn's disease, but it does not specify that methylprednisolone was the sole treatment for Crohn's disease in this case, nor does it indicate that it was effective in treating the disease itself, as it seems to have caused an adverse effect (acute pancreatitis) in this instance." +10341065,Methylprednisolone treats severe acute respiratory syndrome,1277,Twenty-nine of the 30 SARS patients were treated by methylprednisolone.,True,Is the triple 'Methylprednisolone treats severe acute respiratory syndrome' supported by the sentence: 'Twenty-nine of the 30 SARS patients were treated by methylprednisolone.'?,"Yes, it is indirectly supported because it mentions that methylprednisolone was used to treat SARS patients, but it does not explicitly state that it is effective for treating severe acute respiratory syndrome (SARS)." +10289517,Methylprednisolone treats graft versus host disease,1278,"CASE SUMMARY: A 2-year-old white boy with a history of relapsed acute lymphoblastic leukemia underwent a bone marrow transplant and developed graft-versus-host disease, which was treated with methylprednisolone.",True,"Is the triple 'Methylprednisolone treats graft versus host disease' supported by the sentence: 'CASE SUMMARY: A 2-year-old white boy with a history of relapsed acute lymphoblastic leukemia underwent a bone marrow transplant and developed graft-versus-host disease, which was treated with methylprednisolone.'?","Yes, the statement you provided does support, at least indirectly, that methylprednisolone is used to treat graft-versus-host disease (GvHD). The case summary mentions a patient with a history of relapsed acute lymphoblastic leukemia who underwent a bone marrow transplant and developed GvHD, which was subsequently treated with methylprednisolone. This suggests that methylprednisolone is a treatment option for GvHD, even though it doesn't explicitly state that it's the sole treatment for GvHD nor that it's always effective in treating GvHD." +10221573,Methylprednisolone treats myeloproliferative neoplasm,1279,The effects of HDMP should be explored in patients with other subtypes of AML who present with MT.,False,Is the triple 'Methylprednisolone treats myeloproliferative neoplasm' supported by the sentence: 'The effects of HDMP should be explored in patients with other subtypes of AML who present with MT.'?,"No, it is not directly supported, as MPN (myeloproliferative neoplasm) is not mentioned in the given context, which specifically discusses AML (acute myeloid leukemia) patients with mutated tyrosine kinase (MT)." +10136260,Methylprednisolone treats acute lymphoblastic leukemia,1280,"We examined the effect of high-dose methylprednisolone (HDMP) on blast reduction rate and compared it to conventional dose steroid treatment, administered during the first 7+ days of the induction remission period in patients with acute lymphoblastic leukemia (ALL).",True,"Is the triple 'Methylprednisolone treats acute lymphoblastic leukemia' supported by the sentence: 'We examined the effect of high-dose methylprednisolone (HDMP) on blast reduction rate and compared it to conventional dose steroid treatment, administered during the first 7+ days of the induction remission period in patients with acute lymphoblastic leukemia (ALL).'?","Yes, the statement you provided does offer some level of support, albeit indirect, for the assertion that methylprednisolone is used in treating acute lymphoblastic leukemia (ALL). This is because it mentions a study where high-dose methylprednisolone was administered to ALL patients during their induction remission period, implying its use as a treatment. However, it does not explicitly state that methylprednisolone is used to treat ALL, nor does it mention anything about acute lymphoblastic leukemia being in remission after methylprednisolone treatment." +10049014,"Methylprednisolone treats dermatitis, atopic",1281,"The objective of this multicentre, parallel, blinded, randomized controlled study was to evaluate the efficacy and the safety of cyclosporine (CsA group, 117 dogs) in comparison with methylprednisolone (MP group, 59 dogs) in the treatment of atopic dermatitis for 4 months.",True,"Is the triple 'Methylprednisolone treats dermatitis, atopic' supported by the sentence: 'The objective of this multicentre, parallel, blinded, randomized controlled study was to evaluate the efficacy and the safety of cyclosporine (CsA group, 117 dogs) in comparison with methylprednisolone (MP group, 59 dogs) in the treatment of atopic dermatitis for 4 months.'?","Yes, it is indirectly supported because it mentions that methylprednisolone is used in a group for treating dogs with atopic dermatitis in a study, but it does not explicitly state that methylprednisolone directly treats dermatitis, atopic." +9980473,Methylprednisolone treats immunoglobulin a vasculitis,1282,"CASE DESCRIPTION: A 33-year-old woman previously treated with methylprednisolone and cyclophosphamide for Henoch-Schonlein purpura was transferred from a referring hospital because of sore throat, fever, and chills.",False,"Is the triple 'Methylprednisolone treats immunoglobulin a vasculitis' supported by the sentence: 'CASE DESCRIPTION: A 33-year-old woman previously treated with methylprednisolone and cyclophosphamide for Henoch-Schonlein purpura was transferred from a referring hospital because of sore throat, fever, and chills.'?","No, it is not directly supported because the sentence does not mention that methylprednisolone was effective in treating immunoglobulin A (IgA) vasculitis (also known as Henoch-Schonlein purpura). It only states that the patient was previously treated with methylprednisolone for Henoch-Schonlein purpura, but it does not provide information about the outcome of that treatment." +9720542,Methylprednisolone treats lupus nephritis,1283,The last significant breakthrough in the treatment of systemic lupus erythematosus (SLE) was the use of cyclophosphamide and methylprednisolone in the treatment of lupus nephritis.,True,Is the triple 'Methylprednisolone treats lupus nephritis' supported by the sentence: 'The last significant breakthrough in the treatment of systemic lupus erythematosus (SLE) was the use of cyclophosphamide and methylprednisolone in the treatment of lupus nephritis.'?,"Yes, the statement does provide some level of support for the idea that methylprednisolone can be used in the treatment of lupus nephritis, which is a complication of systemic lupus erythematosus (SLE). However, it's important to note that this statement doesn't directly mention that methylprednisolone treats lupus nephritis, but rather that it has been used in its treatment in combination with cyclophosphamide." +8761529,Methylprednisolone treats asthma,1284,Methylprednisolone suleptanate (Promedrol) is a prodrug of methylprednisolone being developed by Pharmacia Corp (formerly Pharmacia & Upjohn) for the treatment of asthma.,True,Is the triple 'Methylprednisolone treats asthma' supported by the sentence: 'Methylprednisolone suleptanate (Promedrol) is a prodrug of methylprednisolone being developed by Pharmacia Corp (formerly Pharmacia & Upjohn) for the treatment of asthma.'?,"Yes, it is indirectly supported because Methylprednisolone is a drug being developed for treating asthma, as mentioned in your provided statement, which aligns with your statement that Methylprednisolone can be used to treat asthma, even though Methylprednisolone Suleptanate (Promedrol) is specifically mentioned in your statement, it is a prodrug of Methylprednisolone, meaning it is a drug that is converted into Methylprednisolone in the body, hence why I said it is an indirect support of your statement." +8588816,Methylprednisolone treats Bell's palsy,1285,"On these basis, we have studied the efficacity of parenteral association of 30 mg/Kg/j of Aciclovir and 1 mg/Kg/j of Methylprednisolone in the treatment of Bell's palsy with less than 12 days of evolution.",True,"Is the triple 'Methylprednisolone treats Bell's palsy' supported by the sentence: 'On these basis, we have studied the efficacity of parenteral association of 30 mg/Kg/j of Aciclovir and 1 mg/Kg/j of Methylprednisolone in the treatment of Bell's palsy with less than 12 days of evolution.'?","Yes, it is indirectly supported because it mentions the use of Methylprednisolone in the treatment of Bell's palsy in combination with Aciclovir." +8568939,Methylprednisolone treats myasthenia gravis,1286,"Treatment with methylprednisolone for myasthenia gravis was associated with a marked decrease in both biochemical markers of bone formation and resorption without any changes in endogenous cAMP and serum levels of calcium, PTH, and 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3].",False,"Is the triple 'Methylprednisolone treats myasthenia gravis' supported by the sentence: 'Treatment with methylprednisolone for myasthenia gravis was associated with a marked decrease in both biochemical markers of bone formation and resorption without any changes in endogenous cAMP and serum levels of calcium, PTH, and 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3].'?","No, this statement does not provide direct evidence that Methylprednisolone treats myasthenia gravis, nor does it refute it. It discusses changes in biochemical markers associated with treatment, not the efficacy of the treatment itself." +8562694,Methylprednisolone treats endocrine exophthalmos,1287,PATIENTS AND METHODS: Fourteen euthyroid patients with severe Graves' ophthalmopathy were treated with high-dose intravenous methylprednisolone during 6 months and followed-up for 24-48 months by clinical and ophthalmological assessment.,True,Is the triple 'Methylprednisolone treats endocrine exophthalmos' supported by the sentence: 'PATIENTS AND METHODS: Fourteen euthyroid patients with severe Graves' ophthalmopathy were treated with high-dose intravenous methylprednisolone during 6 months and followed-up for 24-48 months by clinical and ophthalmological assessment.'?,"Yes, the statement does provide some level of support for the idea that Methylprednisolone can be used to treat endocrine exophthalmos, which is a symptom of Graves' ophthalmopathy, as it describes a study where patients with severe Graves' ophthalmopathy were treated with high-dose intravenous methylprednisolone for a period of six months, with clinical and ophthalmological assessments conducted for a further period of 24-48 months. However, it's important to note that this study does not directly prove that Methylprednisolone is a definitive treatment for endocrine exophthalmos, as further research would be needed to establish this conclusively." +8503951,Methylprednisolone treats ulcerative colitis,1288,The current study evaluated the efficacy and safety of unfractionated heparin in the treatment of ulcerative colitis in comparison with methylprednisolone.,True,Is the triple 'Methylprednisolone treats ulcerative colitis' supported by the sentence: 'The current study evaluated the efficacy and safety of unfractionated heparin in the treatment of ulcerative colitis in comparison with methylprednisolone.'?,"Yes, it is indirectly supported. The sentence mentions that methylprednisolone is used in the treatment of ulcerative colitis, which aligns with the statement that methylprednisolone is used to treat this condition. However, it does not directly support the effectiveness of methylprednisolone in treating ulcerative colitis, but rather implies it." +8464737,Methylprednisolone treats kidney disorder,1289,"Post partum acute renal failure and type IV lupus nephropathy were treated with hemodialysis, methylprednisolone, cyclophosphamide and prednisone.",True,"Is the triple 'Methylprednisolone treats kidney disorder' supported by the sentence: 'Post partum acute renal failure and type IV lupus nephropathy were treated with hemodialysis, methylprednisolone, cyclophosphamide and prednisone.'?","Yes, it is indirectly supported because methylprednisolone is mentioned as a treatment for a type of kidney disorder (type IV lupus nephropathy) in the provided sentence." +8427466,Methylprednisolone treats sinusitis,1290,"To resolve the controversy over whether corticosteroids promote or inhibit the resolution of sinusitis, we present a prospective study of 80 rabbits with surgically introduced pseudomonal sinusitis that were then treated in one of four arms: control, ceftazidime, methylprednisolone, and ceftazidime with methylprednisolone.",True,"Is the triple 'Methylprednisolone treats sinusitis' supported by the sentence: 'To resolve the controversy over whether corticosteroids promote or inhibit the resolution of sinusitis, we present a prospective study of 80 rabbits with surgically introduced pseudomonal sinusitis that were then treated in one of four arms: control, ceftazidime, methylprednisolone, and ceftazidime with methylprednisolone.'?","Yes, it is indirectly supported, as this study investigates the effects of methylprednisolone, a type of corticosteroid, on a form of sinusitis in rabbits, which could potentially provide insights into its use for treating this condition in humans, although further research would be needed to confirm this." +8330903,Methylprednisolone treats systemic lupus erythematosus,1291,MAIN RESULTS: We found no randomised controlled trials comparing cyclophosphamide versus methylprednisolone for the treatment of neuropsychiatric involvement in the systemic lupus erythematosus.,False,Is the triple 'Methylprednisolone treats systemic lupus erythematosus' supported by the sentence: 'MAIN RESULTS: We found no randomised controlled trials comparing cyclophosphamide versus methylprednisolone for the treatment of neuropsychiatric involvement in the systemic lupus erythematosus.'?,"No, it does not support it because it does not provide any information about methylprednisolone treating systemic lupus erythematosus, but rather compares cyclophosphamide to methylprednisolone for a specific type of involvement in systemic lupus erythematosus (neuropsychiatric)." +8291810,Methylprednisolone treats pneumonia,1292,High-dose methylprednisolone was administered for treatment of the pneumonitis.,True,Is the triple 'Methylprednisolone treats pneumonia' supported by the sentence: 'High-dose methylprednisolone was administered for treatment of the pneumonitis.'?,"Yes, it is indirectly supported, as Methylprednisolone is a type of steroid often used to treat inflammation in the body, including that caused by pneumonitis, which is a type of lung inflammation. However, it's important to note that this doesn't necessarily mean it's used for treating pneumonia, as those are two different conditions, even though they both affect the lungs. Always consult with a healthcare professional for medical advice." +8227578,Methylprednisolone treats mucocutaneous lymph node syndrome,1293,"Additional antiinflammatory therapy, such as IV methylprednisolone and IV cyclophosphamide, may be helpful in treating persistent KD.",True,"Is the triple 'Methylprednisolone treats mucocutaneous lymph node syndrome' supported by the sentence: 'Additional antiinflammatory therapy, such as IV methylprednisolone and IV cyclophosphamide, may be helpful in treating persistent KD.'?","Yes, it is indirectly supported because methylprednisolone is mentioned as a potential additional anti-inflammatory therapy for persistent Kawasaki Disease (KD), which is a type of mucocutaneous lymph node syndrome." +8095661,Methylprednisolone treats carpal tunnel syndrome,1294,Injection with methylprednisolone for carpal tunnel syndrome.,True,Is the triple 'Methylprednisolone treats carpal tunnel syndrome' supported by the sentence: 'Injection with methylprednisolone for carpal tunnel syndrome.'?,"Yes, it is indirectly supported as both statements involve Methylprednisolone being used in relation to Carpal Tunnel Syndrome, but they do not explicitly state that Methylprednisolone treats Carpal Tunnel Syndrome in either statement." +8083160,Methylprednisolone treats thrombocytopenia,1295,"After a course of high-dose methylprednisolone therapy with a diagnosis of Evans syndrome, complete response for thrombocytopenia and partial response for anemia was achieved.",True,"Is the triple 'Methylprednisolone treats thrombocytopenia' supported by the sentence: 'After a course of high-dose methylprednisolone therapy with a diagnosis of Evans syndrome, complete response for thrombocytopenia and partial response for anemia was achieved.'?","Yes, it is indirectly supported. The statement mentions that after administering methylprednisolone therapy to a patient with Evans syndrome, there was a complete response for thrombocytopenia, which suggests that methylprednisolone can be an effective treatment for this condition, which is characterized by low platelet count (thrombocytopenia). However, it's important to note that this is just one case study, so further research is needed to confirm these findings." +8063034,Methylprednisolone treats granulomatosis with polyangiitis,1296,We describe a 44-year-old man with Wegener's granulomatosis who was treated with cyclophosphamide and methylprednisolone and who subsequently developed bilateral CMVR.,False,Is the triple 'Methylprednisolone treats granulomatosis with polyangiitis' supported by the sentence: 'We describe a 44-year-old man with Wegener's granulomatosis who was treated with cyclophosphamide and methylprednisolone and who subsequently developed bilateral CMVR.'?,"No, this statement does not support the claim that methylprednisolone is used to treat granulomatosis with polyangiitis (also known as Wegener's granulomatosis). In fact, it suggests that methylprednisolone was used in conjunction with cyclophosphamide to treat a patient who later developed cytomegalovirus retinitis (CMVR). The use of methylprednisolone in this context might be for immunosuppression, but it does not necessarily imply treatment for Wegener's granulomatosis itself." +8018847,Methylprednisolone treats Pain,1297,A comparative trial of botulinum toxin type A and methylprednisolone for the treatment of myofascial pain syndrome and pain from chronic muscle spasm.,True,Is the triple 'Methylprednisolone treats Pain' supported by the sentence: 'A comparative trial of botulinum toxin type A and methylprednisolone for the treatment of myofascial pain syndrome and pain from chronic muscle spasm.'?,"Yes, it is indirectly supported, as both Methylprednisolone and treatment for myofascial pain syndrome (which can cause pain) were mentioned in the same scientific context in your provided reference, indicating a possible link between Methylprednisolone use for pain relief in this condition. However, it's important to note that a direct cause-effect relationship was not explicitly stated in this single statement, so further research would be necessary for a more definitive conclusion on this topic." +7905007,Methylprednisolone treats chronic progressive multiple sclerosis,1298,OBJECTIVE: To determine if there are variables linked to responsiveness to pulse cyclophosphamide/methylprednisolone therapy in progressive Multiple Sclerosis (MS).,False,Is the triple 'Methylprednisolone treats chronic progressive multiple sclerosis' supported by the sentence: 'OBJECTIVE: To determine if there are variables linked to responsiveness to pulse cyclophosphamide/methylprednisolone therapy in progressive Multiple Sclerosis (MS).'?,"No, this statement does not support that Methylprednisolone treats chronic progressive multiple sclerosis. This statement is about a study determining variables linked to responsiveness to pulse cyclophosphamide/methylprednisolone therapy in progressive Multiple Sclerosis (MS), not about Methylprednisolone treating the disease itself." +7853881,Methylprednisolone treats rheumatoid arthritis,1299,Oral low-dose glucocorticosteroids as compared with intravenous methylprednisolone pulses in the treatment of rheumatoid arthritis.,False,Is the triple 'Methylprednisolone treats rheumatoid arthritis' supported by the sentence: 'Oral low-dose glucocorticosteroids as compared with intravenous methylprednisolone pulses in the treatment of rheumatoid arthritis.'?,"No, because in this context, intravenous methylprednisolone pulses are being compared with oral low-dose glucocorticosteroids, not methylprednisolone used to treat rheumatoid arthritis directly." +7827490,Methylprednisolone treats optic neuritis,1300,CONCLUSIONS: The ONTT has led to a dramatic reduction in the use of oral prednisone without a preceding course of intravenous methylprednisolone in the treatment of acute optic neuritis.,True,Is the triple 'Methylprednisolone treats optic neuritis' supported by the sentence: 'CONCLUSIONS: The ONTT has led to a dramatic reduction in the use of oral prednisone without a preceding course of intravenous methylprednisolone in the treatment of acute optic neuritis.'?,"Yes, it is indirectly supported. Methylprednisolone is a type of corticosteroid, like prednisone, that is used to treat inflammation in various conditions, including optic neuritis. The statement suggests that a preceding course of intravenous methylprednisolone is more effective in treating acute optic neuritis than oral prednisone alone, implying that methylprednisolone has a role in treating this condition. However, it does not directly state that methylprednisolone is used to treat optic neuritis, but it is implied in the context of the conclusion." +7808987,Methylprednisolone treats autoimmune thrombocytopenic purpura,1301,CONCLUSION: A short intravenous course of high-dose methylprednisolone is effective as initial treatment of adults with ITP.,True,Is the triple 'Methylprednisolone treats autoimmune thrombocytopenic purpura' supported by the sentence: 'CONCLUSION: A short intravenous course of high-dose methylprednisolone is effective as initial treatment of adults with ITP.'?,"Yes, it is indirectly supported. The conclusion suggests that high-dose methylprednisolone is effective in treating ITP (Idiopathic Thrombocytopenic Purpura), which is an autoimmune disorder, thus supporting the statement that methylprednisolone can treat autoimmune thrombocytopenic purpura, which is a specific type of ITP." +7700869,Methylprednisolone treats Edema,1302,"Lipid peroxidation and oedema in experimental brain injury: comparison of treatment with methylprednisolone, tirilazad mesylate and vitamin E.",True,"Is the triple 'Methylprednisolone treats Edema' supported by the sentence: 'Lipid peroxidation and oedema in experimental brain injury: comparison of treatment with methylprednisolone, tirilazad mesylate and vitamin E.'?","Yes, it is indirectly supported, as methylprednisolone is being compared to other treatments for edema, implying that it has some effect on edema, even though it may not be directly mentioned in this specific context." +7668594,Methylprednisolone treats multiple sclerosis,1303,The same determinations were repeated on plasma and on CSF samples that were collected after the MS patients had ended a six-day treatment with high-dose methylprednisolone (MP).,False,Is the triple 'Methylprednisolone treats multiple sclerosis' supported by the sentence: 'The same determinations were repeated on plasma and on CSF samples that were collected after the MS patients had ended a six-day treatment with high-dose methylprednisolone (MP).'?,"No, this statement does not provide direct evidence that methylprednisolone treats multiple sclerosis (MS). It simply indicates that MS patients had undergone a six-day treatment with high-dose methylprednisolone (MP) and that plasma and cerebrospinal fluid (CSF) samples were collected after the treatment. It does not mention any improvements in MS symptoms or disease progression, which are crucial for establishing a treatment effect." +7649490,Methylprednisolone treats aplastic anemia,1304,"Neutropenic infections are the major cause of morbidity and mortality in the treatment of aplastic anemia (AA) with antilymphocyte globulin (ALG), cyclosporin A (CSA), and methylprednisolone (MP).",True,"Is the triple 'Methylprednisolone treats aplastic anemia' supported by the sentence: 'Neutropenic infections are the major cause of morbidity and mortality in the treatment of aplastic anemia (AA) with antilymphocyte globulin (ALG), cyclosporin A (CSA), and methylprednisolone (MP).'?","Yes, the statement supports it indirectly. Methylprednisolone is one of the treatments for aplastic anemia, and it is mentioned in the context of reducing neutropenic infections, which are a major complication of other treatments for aplastic anemia." +7552935,Methylprednisolone treats Inflammation,1305,Methylprednisolone treatment resulted in the greatest reduction in the inflammatory cell infiltrate but the numbers of infected neurons did not increase concomitantly.,True,Is the triple 'Methylprednisolone treats Inflammation' supported by the sentence: 'Methylprednisolone treatment resulted in the greatest reduction in the inflammatory cell infiltrate but the numbers of infected neurons did not increase concomitantly.'?,"Yes, it is. The statement suggests that Methylprednisolone has an effect on reducing inflammatory cell infiltrate, which is a characteristic of inflammation. Therefore, it supports, though indirectly, that Methylprednisolone is used to treat inflammation." +7483648,Methylprednisolone treats adult acute respiratory distress syndrome,1306,Severe systemic inflammatory response syndrome with shock and ARDS resulting from Still's disease: clinical response with high-dose pulse methylprednisolone therapy.,True,Is the triple 'Methylprednisolone treats adult acute respiratory distress syndrome' supported by the sentence: 'Severe systemic inflammatory response syndrome with shock and ARDS resulting from Still's disease: clinical response with high-dose pulse methylprednisolone therapy.'?,"Yes, it is indirectly supported because the mentioned case study shows a successful treatment of Acute Respiratory Distress Syndrome (ARDS) in a patient with Still's disease using high-dose pulse methylprednisolone therapy, suggesting its potential effectiveness in treating ARDS in adults." +7432980,Methylprednisolone treats myelodysplastic syndrome,1307,Eosinophilic fasciitis associated with autoimmune thyroid disease and myelodysplasia treated with pulsed methylprednisolone and antihistamines.,True,Is the triple 'Methylprednisolone treats myelodysplastic syndrome' supported by the sentence: 'Eosinophilic fasciitis associated with autoimmune thyroid disease and myelodysplasia treated with pulsed methylprednisolone and antihistamines.'?,"Yes, it is indirectly supported because Methylprednisolone was used to treat a case of Myelodysplasia associated with eosinophilic fasciitis, which suggests it could be used for treating Myelodysplastic syndrome, although they are not exactly the same condition." +16097513,Cefotaxime treats osteomyelitis,1308,Cefotaxime in the treatment of chronic osteomyelitis caused by gram-negative bacilli.,True,Is the triple 'Cefotaxime treats osteomyelitis' supported by the sentence: 'Cefotaxime in the treatment of chronic osteomyelitis caused by gram-negative bacilli.'?,"Yes, it is indirectly supported because Cefotaxime is mentioned as a potential treatment for chronic osteomyelitis caused by gram-negative bacilli, which is a type of bacterial infection that can affect bones. However, it does not explicitly state that Cefotaxime is used to treat all types of osteomyelitis, including those caused by other types of bacteria." +15119078,Cefotaxime treats peritonitis,1309,Aztreonam and cefotaxime were compared in 44 cirrhotic patients who had 52 episodes of gram-negative spontaneous peritonitis.,True,Is the triple 'Cefotaxime treats peritonitis' supported by the sentence: 'Aztreonam and cefotaxime were compared in 44 cirrhotic patients who had 52 episodes of gram-negative spontaneous peritonitis.'?,"Yes, it is indirectly supported because both Cefotaxime and Aztreonam were used to treat gram-negative spontaneous peritonitis in cirrhotic patients, as mentioned in the given sentence. However, it does not explicitly state that Cefotaxime is used to treat peritonitis, but it implies that it can be used for that purpose." +11176033,Cefotaxime treats Sepsis,1310,"Due to the apparent volumes of distribution obtained (ranging from 0.48 to 0.51 L/kg), considering the overall clinical efficacy obtained (90% for the 10 mg/kg dose and 75% for the 20 mg/kg dose), and due to the rapid improvement observed after a few doses of the drug (1.8 to 2.5 doses to 'clinical improvement'), it is safe to postulate such doses of cefotaxime as excellent choices for the treatment of septicaemia in dogs.",True,"Is the triple 'Cefotaxime treats Sepsis' supported by the sentence: 'Due to the apparent volumes of distribution obtained (ranging from 0.48 to 0.51 L/kg), considering the overall clinical efficacy obtained (90% for the 10 mg/kg dose and 75% for the 20 mg/kg dose), and due to the rapid improvement observed after a few doses of the drug (1.8 to 2.5 doses to 'clinical improvement'), it is safe to postulate such doses of cefotaxime as excellent choices for the treatment of septicaemia in dogs.'?","Yes, it is indirectly supported because it mentions the clinical efficacy of cefotaxime in treating septicaemia in dogs, which is a form of sepsis, and it suggests that certain doses of cefotaxime have shown good results in treating this condition in dogs." +8153267,Cefotaxime treats bacterial infectious disease,1311,These results suggest that amoxicillin-clavulanic acid is an effective alternative to cefotaxime for the empirical treatment of bacterial infections in cirrhosis.,True,Is the triple 'Cefotaxime treats bacterial infectious disease' supported by the sentence: 'These results suggest that amoxicillin-clavulanic acid is an effective alternative to cefotaxime for the empirical treatment of bacterial infections in cirrhosis.'?,"Yes, because both cefotaxime and amoxicillin-clavulanic acid are antibiotics used to treat bacterial infections, so if one is effective, it implies that treating bacterial infections is effective, which is related to cefotaxime's use for bacterial infections. However, it does not directly support the original statement as it does not mention cefotaxime's effectiveness specifically." +26980543,Ceftriaxone treats Lyme disease,1312,"Most children had received prolonged and repeated courses of oral antimicrobials and/or home intravenous infusion of antimicrobials; 79% had been hospitalized for treatment of suspected LD or management of treatment complications, most notably drug-induced symptoms of gallbladder disease occurring in patients receiving ceftriaxone (Rocephin), and bloodstream infections associated with intravenous catheters.",True,"Is the triple 'Ceftriaxone treats Lyme disease' supported by the sentence: 'Most children had received prolonged and repeated courses of oral antimicrobials and/or home intravenous infusion of antimicrobials; 79% had been hospitalized for treatment of suspected LD or management of treatment complications, most notably drug-induced symptoms of gallbladder disease occurring in patients receiving ceftriaxone (Rocephin), and bloodstream infections associated with intravenous catheters.'?","Yes, it is indirectly supported. The mention of ceftriaxone (Rocephin) in relation to treatment for suspected Lyme disease (LD) implies that it is used as a treatment option, even though it's not explicitly stated that it treats Lyme disease directly in this context." +26401802,Ceftriaxone treats Sepsis,1313,"Clinical study of Rocephin, a 3d generation cephalosporin, in various septicaemias.",True,"Is the triple 'Ceftriaxone treats Sepsis' supported by the sentence: 'Clinical study of Rocephin, a 3d generation cephalosporin, in various septicaemias.'?","Yes, it is indirectly supported. Ceftriaxone is also a 3rd generation cephalosporin like Rocephin, and if Rocephin is shown to be effective in septicaemias (a type of sepsis), it suggests that other 3rd generation cephalosporins could also be effective. However, this is an inference and not a direct claim based on the provided sentence. For a direct claim, we would need a specific study on Ceftriaxone treating sepsis." +18413392,Ceftriaxone treats bacterial pneumonia,1314,"The objectives of this open, prospective, randomized and comparative study were to evaluate and compare the efficacy and safety of intravenous ceftriaxone (active ingredient of Rocephin) and cefotaxime in treatment of bacterial pneumoniae.",True,"Is the triple 'Ceftriaxone treats bacterial pneumonia' supported by the sentence: 'The objectives of this open, prospective, randomized and comparative study were to evaluate and compare the efficacy and safety of intravenous ceftriaxone (active ingredient of Rocephin) and cefotaxime in treatment of bacterial pneumoniae.'?","Yes, the given statement does provide an indirect support to the claim that Ceftriaxone can be used to treat bacterial pneumonia. This is because both Ceftriaxone (the active ingredient in Rocephin) and Cefotaxime are antibiotics used to treat various types of infections caused by bacteria. Therefore, if a study is comparing their efficacy and safety in treating bacterial pneumonia, it implies that both drugs can be used for that purpose. However, it's important to note that a direct claim about Ceftriaxone's effectiveness would require a study specifically focused on Ceftriaxone, not a comparative study with another antibiotic." +25810060,Gefarnate treats gastric ulcer,1315,Clinical trial of Gefarnate in the treatment of gastric ulcer disease.,True,Is the triple 'Gefarnate treats gastric ulcer' supported by the sentence: 'Clinical trial of Gefarnate in the treatment of gastric ulcer disease.'?,"Yes, it is indirectly supported because a clinical trial is a study conducted to assess a medical treatment, which suggests that Gefarnate is being used to treat gastric ulcer disease, aligning with the claim that it treats gastric ulcers, although it does not explicitly state that it does so." +25784688,Gefarnate treats duodenal ulcer,1316,[Clinicobiological evolution of duodenal ulcer treated with gefarnate].,True,Is the triple 'Gefarnate treats duodenal ulcer' supported by the sentence: '[Clinicobiological evolution of duodenal ulcer treated with gefarnate].'?,"Yes, it is indirectly supported, as the title suggests a study on the treatment of duodenal ulcers with gefarnate, implying that gefarnate is used to treat this condition." +19702373,Gefarnate treats peptic ulcer disease,1317,"One hundred and thirty-nine patients with endoscopically confirmed peptic ulcers (gastric and duodenal) entered a double blind comparative evaluation of alprazolam (1.2 mg/day), gefarnate (300 mg/day) and their combination in treatment of peptic ulcer.",True,"Is the triple 'Gefarnate treats peptic ulcer disease' supported by the sentence: 'One hundred and thirty-nine patients with endoscopically confirmed peptic ulcers (gastric and duodenal) entered a double blind comparative evaluation of alprazolam (1.2 mg/day), gefarnate (300 mg/day) and their combination in treatment of peptic ulcer.'?","Yes, the statement does provide indirect support for gefarnate treating peptic ulcer disease, as it mentions a double blind comparative evaluation where gefarnate (300 mg/day) was used in treatment of peptic ulcers (gastric and duodenal)." +22023951,Regadenoson treats coronary artery disorder,1318,CONCLUSIONS: Regadenoson may be a safe vasodilator for CTP and MR MPI in CAD patients.,True,Is the triple 'Regadenoson treats coronary artery disorder' supported by the sentence: 'CONCLUSIONS: Regadenoson may be a safe vasodilator for CTP and MR MPI in CAD patients.'?,"Yes, it is indirectly supported because if Regadenoson is a safe vasodilator for CTP (Computed Tomography Perfusion) and MR MPI (Magnetic Resonance Myocardial Perfusion Imaging) in CAD (Coronary Artery Disease) patients, it implies that it may help treat coronary artery disorders by improving blood flow to the heart muscle, which is a part of the treatment for CAD. However, it's important to note that this is an inference based on a general conclusion, and for a direct support, a more specific statement about treating coronary artery disorders would be needed in the conclusion." +13297277,Meldonium treats Ischemic stroke,1319,A study is presented of the clinico-hemodynamic efficacy of mildronate in 38 patients with ischemic stroke.,True,Is the triple 'Meldonium treats Ischemic stroke' supported by the sentence: 'A study is presented of the clinico-hemodynamic efficacy of mildronate in 38 patients with ischemic stroke.'?,"Yes, it is indirectly supported. The provided sentence mentions a study on the clinical and hemodynamic efficacy of Mildronate (also known as Meldonium) in patients with ischemic stroke, which suggests a potential benefit in treating this condition, even if it does not directly prove that Meldonium treats ischemic stroke." +25624167,Neobiotic treats pneumonia,1320,Use of neomycin for treatment of Rhodococcus equi pneumonia in foals.,True,Is the triple 'Neobiotic treats pneumonia' supported by the sentence: 'Use of neomycin for treatment of Rhodococcus equi pneumonia in foals.'?,"Yes, it is indirectly supported, as both sentences refer to treating pneumonia with a type of antibiotic, specifically neomycin in this case." +11022701,Neobiotic treats bacterial infectious disease with sepsis,1321,Osteomyelitis of the cervical vertebras as a complication of urinary tract disease; Proteus bacteremia treated with neomycin.,True,Is the triple 'Neobiotic treats bacterial infectious disease with sepsis' supported by the sentence: 'Osteomyelitis of the cervical vertebras as a complication of urinary tract disease; Proteus bacteremia treated with neomycin.'?,"Yes, it is indirectly supported because both statements involve treating a bacterial infection (Proteus bacteremia in this case) using an antibiotic (neomycin), which is a type of neobiotic. However, it does not directly support that neobiotics treat bacterial infections causing sepsis." +24398401,BLINATUMOMAB treats B-cell chronic lymphocytic leukemia,1322,Lineage Conversion in Pediatric B-Cell Precursor Acute Leukemia under Blinatumomab Therapy.,False,Is the triple 'BLINATUMOMAB treats B-cell chronic lymphocytic leukemia' supported by the sentence: 'Lineage Conversion in Pediatric B-Cell Precursor Acute Leukemia under Blinatumomab Therapy.'?,"No, it is not directly nor indirectly supported, as Blinatumomab is used for treating a different type of leukemia, namely precursor B-cell acute lymphoblastic leukemia, not B-cell chronic lymphocytic leukemia, as per the mentioned study about lineage conversion under Blinatumomab therapy in pediatric patients with precursor B-cell acute lymphoblastic leukemia." +23073290,BLINATUMOMAB treats Precursor B-Cell Lymphoblastic Leukemia-Lymphoma,1323,"We report on the Australian experience of blinatumomab for treatment of 24 children with relapsed/refractory precursor B-cell acute lymphoblastic leukaemia (B-ALL) and high-risk genetics, resulting in a minimal residual disease (MRD) response rate of 58%, 2-year progression-free survival (PFS) of 39% and 2-year overall survival of 63%.",True,"Is the triple 'BLINATUMOMAB treats Precursor B-Cell Lymphoblastic Leukemia-Lymphoma' supported by the sentence: 'We report on the Australian experience of blinatumomab for treatment of 24 children with relapsed/refractory precursor B-cell acute lymphoblastic leukaemia (B-ALL) and high-risk genetics, resulting in a minimal residual disease (MRD) response rate of 58%, 2-year progression-free survival (PFS) of 39% and 2-year overall survival of 63%.'?","Yes, the sentence does support that BLINATUMOMAB treats Precursor B-Cell Lymphoblastic Leukemia-Lymphoma (B-ALL) indirectly. It mentions that children with relapsed/refractory precursor B-cell acute lymphoblastic leukaemia were treated with blinatumomab, resulting in a significant response rate and survival rate." +21932754,BLINATUMOMAB treats acute lymphoblastic leukemia,1324,"Blinatumomab for Acute Lymphoblastic Leukemia: The First Bispecific T-Cell Engager Antibody to Be Approved by the EMA for Minimal Residual Disease.On November 15, 2018, the Committee for Medicinal Products for Human Use (CHMP) recommended the extension of indication for blinatumomab to include the treatment of adults with minimal residual disease (MRD) positive B-cell precursor acute lymphoblastic leukemia (ALL).",True,"Is the triple 'BLINATUMOMAB treats acute lymphoblastic leukemia' supported by the sentence: 'Blinatumomab for Acute Lymphoblastic Leukemia: The First Bispecific T-Cell Engager Antibody to Be Approved by the EMA for Minimal Residual Disease.On November 15, 2018, the Committee for Medicinal Products for Human Use (CHMP) recommended the extension of indication for blinatumomab to include the treatment of adults with minimal residual disease (MRD) positive B-cell precursor acute lymphoblastic leukemia (ALL).'?","Yes, the statement supports that Blinatumomab is used for treating Acute Lymphoblastic Leukemia (ALL) as it has been approved for treating MRD (Minimal Residual Disease) positive B-cell precursor ALL, indicating that it is a treatment option for ALL patients who have residual disease after initial therapy." +21720587,BLINATUMOMAB treats lymphoma,1325,"Cytokine storm was reported in four patients (19%).In conclusion, treatment with blinatumomab is effective and tolerable in adult patients with relapsed/refractory B-ALL outside of a clinical trial stetting.",True,"Is the triple 'BLINATUMOMAB treats lymphoma' supported by the sentence: 'Cytokine storm was reported in four patients (19%).In conclusion, treatment with blinatumomab is effective and tolerable in adult patients with relapsed/refractory B-ALL outside of a clinical trial stetting.'?","Yes, it is indirectly supported, as it mentions that treatment with blinatumomab is effective for adult patients with relapsed/refractory B-ALL, which is a type of lymphoma, but it does not explicitly state that blinatumomab treats lymphoma. The mention of cytokine storm, a possible side-effect, further supports this claim." +9387116,Ciprofloxacin physically interacts with DNA Gyrase,1326,"UNLABELLED: Ciprofloxacin, a quinolone antibiotic drug, binds to DNA topoisomerase IV and DNA gyrase of various bacteria.",True,"Is the triple 'Ciprofloxacin physically interacts with DNA Gyrase' supported by the sentence: 'UNLABELLED: Ciprofloxacin, a quinolone antibiotic drug, binds to DNA topoisomerase IV and DNA gyrase of various bacteria.'?","Yes, the statement supports the interaction between Ciprofloxacin and DNA gyrase. The phrase ""binds to DNA topoisomerase IV and DNA gyrase of various bacteria"" indicates a physical interaction." +8212496,Ciprofloxacin physically interacts with DNA Gyrase,1327,Topoisomerase IV and DNA gyrase were purified from a ciprofloxacin-sensitive Streptococcus pneumoniae strain and from two clinical isolates of S. pneumoniae with high-level resistance to ciprofloxacin by means of a gene cloning method in Escherichia coli.,True,Is the triple 'Ciprofloxacin physically interacts with DNA Gyrase' supported by the sentence: 'Topoisomerase IV and DNA gyrase were purified from a ciprofloxacin-sensitive Streptococcus pneumoniae strain and from two clinical isolates of S. pneumoniae with high-level resistance to ciprofloxacin by means of a gene cloning method in Escherichia coli.'?,"Yes, it is supported. The fact that both sensitive and resistant strains of S. pneumoniae were used in the study suggests that ciprofloxacin has some form of interaction with these bacterial enzymes, including DNA gyrase, which is a type of topoisomerase. However, the study does not explicitly state that ciprofloxacin physically interacts with DNA gyrase, so it's an indirect support based on the context." +7781719,Ciprofloxacin affects DNA Gyrase,1328,"The concentrations of ciprofloxacin, sparfloxacin, levofloxacin, or ofloxacin required to inhibit wild-type topoisomerase IV were 8 to 16 times lower than those required to inhibit wild-type DNA gyrase.",True,"Is the triple 'Ciprofloxacin affects DNA Gyrase' supported by the sentence: 'The concentrations of ciprofloxacin, sparfloxacin, levofloxacin, or ofloxacin required to inhibit wild-type topoisomerase IV were 8 to 16 times lower than those required to inhibit wild-type DNA gyrase.'?","Yes, it is indirectly supported by the given sentence. The lower concentration required to inhibit topoisomerase IV suggests that higher concentration is needed for DNA gyrase, implying that ciprofloxacin does affect DNA gyrase, albeit less potently than topoisomerase IV." +18400322,Ciprofloxacin affects DNA Gyrase,1329,Plasmid-encoded protein QnrB1 protects DNA gyrase from ciprofloxacin inhibition.,True,Is the triple 'Ciprofloxacin affects DNA Gyrase' supported by the sentence: 'Plasmid-encoded protein QnrB1 protects DNA gyrase from ciprofloxacin inhibition.'?,"Yes, it is. The given statement suggests that Ciprofloxacin inhibits DNA gyrase, and that a plasmid-encoded protein, QnrB1, can protect against this inhibition. This implies that Ciprofloxacin's effect on DNA Gyrase is real, thus providing support for the statement that Ciprofloxacin affects DNA Gyrase, albeit indirectly through the action of QnrB1." +24010235,Ciprofloxacin treats chronic bronchitis,1330,"Thirty four patients with acute purulent exacerbations of chronic bronchitis were treated with 500 mg ciprofloxacin twice daily, orally, for ten days.",True,"Is the triple 'Ciprofloxacin treats chronic bronchitis' supported by the sentence: 'Thirty four patients with acute purulent exacerbations of chronic bronchitis were treated with 500 mg ciprofloxacin twice daily, orally, for ten days.'?","Yes, it is indirectly supported because the sentence mentions treatment of acute purulent exacerbations of chronic bronchitis with Ciprofloxacin, indicating its use in managing this condition, although it doesn't explicitly state that it treats chronic bronchitis itself." +22484062,Ciprofloxacin treats amyotrophic lateral sclerosis,1331,"OBJECTIVE: To evaluate the efficacy of a fixed-dose combination of two approved drugs, Ciprofloxacin and Celecoxib, as a potential therapeutic treatment for amyotrophic lateral sclerosis (ALS).",False,"Is the triple 'Ciprofloxacin treats amyotrophic lateral sclerosis' supported by the sentence: 'OBJECTIVE: To evaluate the efficacy of a fixed-dose combination of two approved drugs, Ciprofloxacin and Celecoxib, as a potential therapeutic treatment for amyotrophic lateral sclerosis (ALS).'?","No, the statement does not directly support that Ciprofloxacin treats amyotrophic lateral sclerosis (ALS). It suggests that a combination of Ciprofloxacin and Celecoxib is being evaluated for potential therapeutic effects on ALS, but it does not confirm that Ciprofloxacin alone is an effective treatment for ALS." +21488232,Ciprofloxacin treats Infection,1332,Noncytotoxic Pyrrolobenzodiazepine-Ciprofloxacin Conjugate with Activity against Mycobacterium tuberculosis .The development of new antitubercular agents for the treatment of infections caused by multidrug-resistant (MDR) Mycobacterium tuberculosis is an urgent priority.,True,Is the triple 'Ciprofloxacin treats Infection' supported by the sentence: 'Noncytotoxic Pyrrolobenzodiazepine-Ciprofloxacin Conjugate with Activity against Mycobacterium tuberculosis .The development of new antitubercular agents for the treatment of infections caused by multidrug-resistant (MDR) Mycobacterium tuberculosis is an urgent priority.'?,"Yes, it is indirectly supported because Ciprofloxacin is an antibiotic used to treat various types of bacterial infections, including those caused by Mycobacterium tuberculosis, as mentioned in the given abstract. Therefore, it can be inferred that Ciprofloxacin does treat infection caused by Mycobacterium tuberculosis, even though the abstract focuses on a specific conjugate of Ciprofloxacin with a non-toxic pyrrolobenzodiazepine for enhanced activity against MDR Mycobacterium tuberculosis infections." +20040173,Ciprofloxacin treats lymphoma,1333,Antibacterial prophylaxis with ciprofloxacin for patients with multiple myeloma and lymphoma undergoing autologous haematopoietic cell transplantation: a quasi-experimental single-centre before-after study.,False,Is the triple 'Ciprofloxacin treats lymphoma' supported by the sentence: 'Antibacterial prophylaxis with ciprofloxacin for patients with multiple myeloma and lymphoma undergoing autologous haematopoietic cell transplantation: a quasi-experimental single-centre before-after study.'?,"No, it is not directly supported because Ciprofloxacin is used for antibacterial prophylaxis, not for treating lymphoma directly. However, it could be indirectly beneficial as part of a preventative care regimen in patients undergoing certain procedures, as suggested in the study you mentioned." +19067853,Ciprofloxacin treats B-cell chronic lymphocytic leukemia,1334,A case of septic arthritis caused by a Mycoplasma salivarium strain resistant towards Ciprofloxacin and Clarithromycin in a patient with chronic lymphatic leukemia.,False,Is the triple 'Ciprofloxacin treats B-cell chronic lymphocytic leukemia' supported by the sentence: 'A case of septic arthritis caused by a Mycoplasma salivarium strain resistant towards Ciprofloxacin and Clarithromycin in a patient with chronic lymphatic leukemia.'?,"No, this sentence does not support that Ciprofloxacin treats B-cell chronic lymphocytic leukemia, but it does show that Ciprofloxacin can be used to treat infections in patients with this type of leukemia, even if the specific strain is resistant to it." +14572951,Ciprofloxacin treats hearing loss disorder,1335,Treatment with ciprofloxacin and ceftazidime improved the hearing loss significantly.,True,Is the triple 'Ciprofloxacin treats hearing loss disorder' supported by the sentence: 'Treatment with ciprofloxacin and ceftazidime improved the hearing loss significantly.'?,"Yes, this statement can be seen as indirect support for the idea that Ciprofloxacin can help treat hearing loss, as it suggests that treatment involving Ciprofloxacin led to a significant improvement in hearing loss. However, it's important to note that this is an indirect inference, as the statement doesn't directly claim that Ciprofloxacin alone is responsible for this improvement." +14398199,Ciprofloxacin treats sinusitis,1336,"CASE SUMMARY: A 24-year-old woman was admitted to the hospital because of convulsions, severe myopathy, and acute renal failure after taking ciprofloxacin for sinusitis, and urinary tract infections.",True,"Is the triple 'Ciprofloxacin treats sinusitis' supported by the sentence: 'CASE SUMMARY: A 24-year-old woman was admitted to the hospital because of convulsions, severe myopathy, and acute renal failure after taking ciprofloxacin for sinusitis, and urinary tract infections.'?","Yes, the statement ""Ciprofloxacin treats sinusitis"" is indirectly supported by this case summary, as it mentions a patient who took Ciprofloxacin for sinusitis, even though complications arose in this particular case. However, it's important to note that Ciprofloxacin is generally used for treating infections, including those of the sinuses, but it can have side effects as seen in this case." +14311974,Ciprofloxacin treats liver abscess (disease),1337,Chromobacterium violaceum endocarditis and hepatic abscesses treated successfully with meropenem and ciprofloxacin.,True,Is the triple 'Ciprofloxacin treats liver abscess (disease)' supported by the sentence: 'Chromobacterium violaceum endocarditis and hepatic abscesses treated successfully with meropenem and ciprofloxacin.'?,"Yes, it is indirectly supported because it mentions that Ciprofloxacin was used to treat hepatic abscesses caused by Chromobacterium violaceum endocarditis, which is a type of disease. However, it does not specifically mention that Ciprofloxacin is effective in treating all types of liver abscesses, which is a broader category of disease." +14284683,Ciprofloxacin treats gastroenteritis,1338,"A patient is reported who had previously maintained a stable prothrombin time on Coumadin for 5 years, and who exhibited a marked prolongation of prothrombin time when placed on ciprofloxacin for gastroenteritis.",True,"Is the triple 'Ciprofloxacin treats gastroenteritis' supported by the sentence: 'A patient is reported who had previously maintained a stable prothrombin time on Coumadin for 5 years, and who exhibited a marked prolongation of prothrombin time when placed on ciprofloxacin for gastroenteritis.'?","Yes, the statement does provide some level of support for the idea that Ciprofloxacin can treat gastroenteritis, albeit indirectly. It suggests that a patient was treated with Ciprofloxacin for gastroenteritis and that this treatment had an effect on their prothrombin time, which is a measure of blood clotting time. However, it does not directly state that Ciprofloxacin cures or improves gastroenteritis symptoms." +14141218,Ciprofloxacin treats castration-resistant prostate carcinoma,1339,"Doxorubicin and docetaxel, two standard antineoplastic agents in hormone-refractory prostate cancer (HRPC) therapy and ciprofloxacin were evaluated singly and in several simultaneous and sequential drug combination schemes, against PC-3 and LNCaP cell lines.",False,"Is the triple 'Ciprofloxacin treats castration-resistant prostate carcinoma' supported by the sentence: 'Doxorubicin and docetaxel, two standard antineoplastic agents in hormone-refractory prostate cancer (HRPC) therapy and ciprofloxacin were evaluated singly and in several simultaneous and sequential drug combination schemes, against PC-3 and LNCaP cell lines.'?","No, it is not directly supported because the statement does not mention that ciprofloxacin treats castration-resistant prostate carcinoma, but it suggests that ciprofloxacin is being evaluated in relation to prostate cancer cells, which could potentially support it indirectly depending on the outcomes of those evaluations." +14005051,Ciprofloxacin treats acute myeloid leukemia,1340,"Results of combination therapy with amifostine, pentoxifylline, ciprofloxacin and dexamethasone in patients with myelodysplastic syndrome and acute myeloid leukemia.",False,"Is the triple 'Ciprofloxacin treats acute myeloid leukemia' supported by the sentence: 'Results of combination therapy with amifostine, pentoxifylline, ciprofloxacin and dexamethasone in patients with myelodysplastic syndrome and acute myeloid leukemia.'?","No, it is not directly supported because Ciprofloxacin is mentioned in combination with other substances, not as a standalone treatment for acute myeloid leukemia." +13846017,Ciprofloxacin treats lung disorder,1341,High dose parenteral ciprofloxacin in pleuro-pulmonary disease: a comparative pharmacolinetics of 400 and 200 mg intravenous.,False,Is the triple 'Ciprofloxacin treats lung disorder' supported by the sentence: 'High dose parenteral ciprofloxacin in pleuro-pulmonary disease: a comparative pharmacolinetics of 400 and 200 mg intravenous.'?,"No, it does not provide a direct confirmation that Ciprofloxacin treats lung disorders, but it does suggest that high-dose Ciprofloxacin has been studied in relation to pleuro-pulmonary disease, which is a type of lung disease, indicating potential use in this area of medicine." +13663890,Ciprofloxacin treats otitis media,1342,[Pneumococcal meningitis during ciprofloxacin therapy for otitis media].,False,Is the triple 'Ciprofloxacin treats otitis media' supported by the sentence: '[Pneumococcal meningitis during ciprofloxacin therapy for otitis media].'?,"No, it is not directly or indirectly supported because pneumococcal meningitis is a different condition than otitis media, even though they both involve ears. The given sentence describes a case of pneumococcal meningitis during ciprofloxacin therapy for otitis media, but it does not imply that ciprofloxacin is effective in treating otitis media, nor does it say anything about whether ciprofloxacin can prevent otitis media from developing into pneumococcal meningitis." +11840711,Ciprofloxacin treats cataract,1343,"CONCLUSIONS: Ofloxacin has higher corneal penetration and ability to exceed MIC90 of common ocular contaminants than ciprofloxacin, and would be a more appropriate prophylactic choice for canine cataract patients.",False,"Is the triple 'Ciprofloxacin treats cataract' supported by the sentence: 'CONCLUSIONS: Ofloxacin has higher corneal penetration and ability to exceed MIC90 of common ocular contaminants than ciprofloxacin, and would be a more appropriate prophylactic choice for canine cataract patients.'?","No, it is not directly or indirectly supported, as this statement compares the corneal penetration of Ciprofloxacin with that of Ofloxacin, but it does not mention any effect on cataracts." +11684450,Ciprofloxacin treats cystitis,1344,Amoxicillin-clavulanate vs ciprofloxacin for the treatment of uncomplicated cystitis in women: a randomized trial.,True,Is the triple 'Ciprofloxacin treats cystitis' supported by the sentence: 'Amoxicillin-clavulanate vs ciprofloxacin for the treatment of uncomplicated cystitis in women: a randomized trial.'?,"Yes, it is indirectly supported because both Ciprofloxacin and Amoxicillin-clavulanate were used to treat uncomplicated cystitis in women in a randomized trial, implying that Ciprofloxacin is indeed used to treat this condition." +11679354,Ciprofloxacin treats Pseudomonas infection,1345,We used a simple Wood's light examination and culture to establish the diagnosis of Pseudomonas toe web infection and achieved rapid resolution with oral ciprofloxacin treatment and local application of Castellani's paint.,True,Is the triple 'Ciprofloxacin treats Pseudomonas infection' supported by the sentence: 'We used a simple Wood's light examination and culture to establish the diagnosis of Pseudomonas toe web infection and achieved rapid resolution with oral ciprofloxacin treatment and local application of Castellani's paint.'?,"Yes, this statement does provide support for the idea that Ciprofloxacin can be used to treat Pseudomonas infections, as it mentions the use of Ciprofloxacin to treat a diagnosed case of Pseudomonas toe web infection. However, it's important to note that this is just one case, and further research is needed to establish a more general conclusion." +11628762,Ciprofloxacin treats endophthalmitis,1346,Ciprofloxacin in endophthalmitis: an alternative to ceftazidime and amikacin!,True,Is the triple 'Ciprofloxacin treats endophthalmitis' supported by the sentence: 'Ciprofloxacin in endophthalmitis: an alternative to ceftazidime and amikacin!'?,"Yes, it is. The title of the article you mentioned suggests that Ciprofloxacin can be used as an alternative treatment for endophthalmitis, which aligns with the statement that Ciprofloxacin can treat this condition, even if it's not a primary treatment option in most cases." +11564697,Ciprofloxacin treats chronic obstructive pulmonary disease,1347,Reported here is the case of a patient with underlying chronic obstructive pulmonary disease (COPD) in whom ciprofloxacin treatment of a lower respiratory tract infection failed subsequent to ciprofloxacin treatment of an exacerbation of COPD several weeks earlier.,False,Is the triple 'Ciprofloxacin treats chronic obstructive pulmonary disease' supported by the sentence: 'Reported here is the case of a patient with underlying chronic obstructive pulmonary disease (COPD) in whom ciprofloxacin treatment of a lower respiratory tract infection failed subsequent to ciprofloxacin treatment of an exacerbation of COPD several weeks earlier.'?,"No, this statement does not support that Ciprofloxacin treats COPD, but rather suggests that Ciprofloxacin may not be effective in treating certain infections in patients with COPD." +11304087,Ciprofloxacin treats eye infectious disorder,1348,This PK-MB model may be very useful in optimizing treatments of various eye infections with ciprofloxacin.,True,Is the triple 'Ciprofloxacin treats eye infectious disorder' supported by the sentence: 'This PK-MB model may be very useful in optimizing treatments of various eye infections with ciprofloxacin.'?,"Yes, it is indirectly supported because if a pharmacokinetic-microbiological (PK-MB) model is useful in optimizing treatments of various eye infections with ciprofloxacin, it suggests that ciprofloxacin is indeed effective in treating such infections, even if it doesn't explicitly mention 'eye infectious disorders'." +11059709,Ciprofloxacin treats abscess,1349,"The patient was asymptomatic for a month, but the abscess reactivated and was treated with Vancomycin and Ciprofloxacin administered intravenously.",True,"Is the triple 'Ciprofloxacin treats abscess' supported by the sentence: 'The patient was asymptomatic for a month, but the abscess reactivated and was treated with Vancomycin and Ciprofloxacin administered intravenously.'?","Yes, it is indirectly supported because Ciprofloxacin is mentioned as being used in the treatment of the reactivated abscess, implying that it is effective against it. However, it's important to note that both Vancomycin and Ciprofloxacin were used, so it's not clear which drug had the primary effect on the abscess." +10087799,Ciprofloxacin treats bacterial infectious disease,1350,"Fluoroquinolones such as ciprofloxacin, levofloxacin, moxifloxacin and gatifloxacin are widely used for the treatment of bacterial infections.",True,"Is the triple 'Ciprofloxacin treats bacterial infectious disease' supported by the sentence: 'Fluoroquinolones such as ciprofloxacin, levofloxacin, moxifloxacin and gatifloxacin are widely used for the treatment of bacterial infections.'?","Yes, it is indirectly supported because Ciprofloxacin is a type of Fluoroquinolone, which is used for treating bacterial infections, as stated in the given sentence." +10013051,Ciprofloxacin treats plague,1351,There are no previous reports of plague being successfully treated with ciprofloxacin.,False,Is the triple 'Ciprofloxacin treats plague' supported by the sentence: 'There are no previous reports of plague being successfully treated with ciprofloxacin.'?,"No, it is not directly or indirectly supported, as it suggests that ciprofloxacin has not been successful in treating plague in the past, implying that further research is needed to confirm its effectiveness against this disease." +10002223,Ciprofloxacin treats anthrax infection,1352,Treatment and post-exposure prophylaxis for anthrax are ciprofloxacin or doxycycline.,True,Is the triple 'Ciprofloxacin treats anthrax infection' supported by the sentence: 'Treatment and post-exposure prophylaxis for anthrax are ciprofloxacin or doxycycline.'?,"Yes, it is indirectly supported because Ciprofloxacin is listed as a treatment option for anthrax infections in the provided sentence." +9704134,Ciprofloxacin treats bronchiectasis,1353,"He had severe airway obstruction and focal bronchiectasis, and responded to treatment with ciprofloxacin and clarithromycin.",True,"Is the triple 'Ciprofloxacin treats bronchiectasis' supported by the sentence: 'He had severe airway obstruction and focal bronchiectasis, and responded to treatment with ciprofloxacin and clarithromycin.'?","Yes, it is indirectly supported. The sentence suggests that the individual, who had bronchiectasis, responded to treatment involving Ciprofloxacin, indicating a potential positive effect of Ciprofloxacin on bronchiectasis. However, it's important to note that the individual was also treated with Clarithromycin, so it's not possible to attribute the positive response solely to Ciprofloxacin based on this information alone." +9552171,Ciprofloxacin treats otitis externa,1354,"The objective of this study was to evaluate and compare the efficacy of topical otic powder, tobramycin drops and ciprofloxacin drops in patients suffering from AEO.",True,"Is the triple 'Ciprofloxacin treats otitis externa' supported by the sentence: 'The objective of this study was to evaluate and compare the efficacy of topical otic powder, tobramycin drops and ciprofloxacin drops in patients suffering from AEO.'?","Yes, it is indirectly supported because the statement mentions that Ciprofloxacin drops were used in a study evaluating treatments for Acute External Otitis (AEO), which includes Otitis Externa as a subtype. However, it does not explicitly state that Ciprofloxacin is used for treating Otitis Externa in particular, but rather as part of a broader treatment evaluation for AEO." +9504629,Ciprofloxacin treats Sepsis,1355,Ciprofloxacin pharmacokinetic profiles in paediatric sepsis: how much ciprofloxacin is enough?,False,Is the triple 'Ciprofloxacin treats Sepsis' supported by the sentence: 'Ciprofloxacin pharmacokinetic profiles in paediatric sepsis: how much ciprofloxacin is enough?'?,"No, it is not directly or indirectly supported because the provided sentence is about pharmacokinetic profiles of Ciprofloxacin in paediatric sepsis, not about whether Ciprofloxacin treats sepsis." +9281470,Ciprofloxacin treats prostatitis,1356,The emergence and evolution of quinolone-resistant Escherichia coli in faeces of patients with prostatitis treated with high-dose oral ciprofloxacin for 1 month were studied.,True,Is the triple 'Ciprofloxacin treats prostatitis' supported by the sentence: 'The emergence and evolution of quinolone-resistant Escherichia coli in faeces of patients with prostatitis treated with high-dose oral ciprofloxacin for 1 month were studied.'?,"Yes, it is indirectly supported. The sentence mentions a study on patients with prostatitis who were treated with Ciprofloxacin, which suggests that Ciprofloxacin is used to treat prostatitis. However, it does not directly state that Ciprofloxacin treats prostatitis, hence it's an indirect support." +8956827,Ciprofloxacin treats Abdominal Infection,1357,"Ciprofloxacin is effective in the treatment of serious, non-self-limiting intra-abdominal infections, peritonitis in CAPD, pelvic inflammatory disease, endometritis and gall-bladder infections.",True,"Is the triple 'Ciprofloxacin treats Abdominal Infection' supported by the sentence: 'Ciprofloxacin is effective in the treatment of serious, non-self-limiting intra-abdominal infections, peritonitis in CAPD, pelvic inflammatory disease, endometritis and gall-bladder infections.'?","Yes, it is indirectly supported because Ciprofloxacin is indeed mentioned as effective in treating various intra-abdominal infections, which could include abdominal infections, among other conditions listed in your provided sentence." +8754779,Ciprofloxacin treats rhinoscleroma,1358,We report on a young patient with nasal rhinoscleroma who achieved resolution after treatment with oral ciprofloxacin.,True,Is the triple 'Ciprofloxacin treats rhinoscleroma' supported by the sentence: 'We report on a young patient with nasal rhinoscleroma who achieved resolution after treatment with oral ciprofloxacin.'?,"Yes, it is indirectly supported because it mentions that oral ciprofloxacin was used to treat a case of nasal rhinoscleroma, which suggests that ciprofloxacin could be an effective treatment for this condition." +8350437,Ciprofloxacin treats pyelonephritis,1359,Is a 7-day course of ciprofloxacin effective in the treatment of uncomplicated pyelonephritis in women?,True,Is the triple 'Ciprofloxacin treats pyelonephritis' supported by the sentence: 'Is a 7-day course of ciprofloxacin effective in the treatment of uncomplicated pyelonephritis in women?'?,"Yes, it is indirectly supported because both sentences discuss the effectiveness of Ciprofloxacin in treating pyelonephritis, although they do not explicitly state that Ciprofloxacin treats pyelonephritis in all cases, but rather imply it through discussing its effectiveness in treatment." +8337570,Ciprofloxacin treats bacterial infectious disease with sepsis,1360,"Despite prolonged bacteremia, the response to long-term therapy with ciprofloxacin and rifampin was excellent.",True,"Is the triple 'Ciprofloxacin treats bacterial infectious disease with sepsis' supported by the sentence: 'Despite prolonged bacteremia, the response to long-term therapy with ciprofloxacin and rifampin was excellent.'?","Yes, it is indirectly supported. The sentence mentions that long-term therapy with ciprofloxacin (which is an antibiotic used to treat various types of bacterial infections) led to an excellent response in a patient with prolonged bacteremia (bacteria in the bloodstream, a type of bacterial infection). Therefore, it suggests that ciprofloxacin is effective in treating certain types of bacterial infections, which aligns with the statement that ciprofloxacin treats bacterial infections, including those that can lead to sepsis (a severe complication of bacteremia)." +8194797,Ciprofloxacin treats neutropenia,1361,The proportion of patients who developed neutropenia and fever was 87% in the group treated with ciprofloxacin and 78% in the group treated with ciprofloxacin and rifampin (P =.25).,False,Is the triple 'Ciprofloxacin treats neutropenia' supported by the sentence: 'The proportion of patients who developed neutropenia and fever was 87% in the group treated with ciprofloxacin and 78% in the group treated with ciprofloxacin and rifampin (P =.25).'?,"No, it does not support it directly, because it does not clearly state that ciprofloxacin treats neutropenia, but rather compares two different treatment groups with ciprofloxacin, one with additional rifampin, regarding their incidence of neutropenia and fever." +8190776,Ciprofloxacin treats peritonitis,1362,"Peritonitis due to S. aureus ESI was significantly less frequent among patients treated with ciprofloxacin (1 vs 9 cases, p = 0.001).",True,"Is the triple 'Ciprofloxacin treats peritonitis' supported by the sentence: 'Peritonitis due to S. aureus ESI was significantly less frequent among patients treated with ciprofloxacin (1 vs 9 cases, p = 0.001).'?","Yes, the statement provides evidence that ciprofloxacin may be effective in treating certain types of peritonitis, in this case, those caused by Staphylococcus aureus ESI, as there was a significant difference in frequency between those treated with ciprofloxacin and those not. However, it's important to note that this is a specific context and ciprofloxacin may not be effective for all types of peritonitis." +8088120,Ciprofloxacin treats Fever,1363,"In the current study, the authors examined the use of ciprofloxacin as outpatient management in selected patients with fever during an episode of neutropenia.",True,"Is the triple 'Ciprofloxacin treats Fever' supported by the sentence: 'In the current study, the authors examined the use of ciprofloxacin as outpatient management in selected patients with fever during an episode of neutropenia.'?","Yes, it is indirectly supported because Ciprofloxacin is mentioned as a potential treatment for fever during neutropenia in the given sentence, which suggests that it could be used to treat fever. However, it's important to note that this is an inference based on a single statement in a specific context; for a more definitive conclusion, a comprehensive review of relevant medical literature would be required." +7880629,Ciprofloxacin treats osteomyelitis,1364,"The efficacy and safety of three oral fluoroquinolones (lomefloxacin, levofloxacin, and ciprofloxacin) for the treatment of chronic osteomyelitis were analyzed.",True,"Is the triple 'Ciprofloxacin treats osteomyelitis' supported by the sentence: 'The efficacy and safety of three oral fluoroquinolones (lomefloxacin, levofloxacin, and ciprofloxacin) for the treatment of chronic osteomyelitis were analyzed.'?","Yes, it is indirectly supported because Ciprofloxacin is one of the oral fluoroquinolones analyzed for treating chronic osteomyelitis in this study, as stated in your given quote." +7798648,Ciprofloxacin treats cystic fibrosis,1365,"As juveniles are especially sensitive, use of these drugs in paediatrics should be restricted to carefully selected indications (such as the use of ciprofloxacin in cystic fibrosis).",True,"Is the triple 'Ciprofloxacin treats cystic fibrosis' supported by the sentence: 'As juveniles are especially sensitive, use of these drugs in paediatrics should be restricted to carefully selected indications (such as the use of ciprofloxacin in cystic fibrosis).'?","Yes, the statement does provide some level of support for the idea that Ciprofloxacin is used in treating cystic fibrosis, although it does not directly state that Ciprofloxacin is effective in treating cystic fibrosis. It suggests that Ciprofloxacin is used in pediatric cases of cystic fibrosis, implying that it has some therapeutic value in this context. However, for a direct confirmation of its effectiveness, a more explicit statement or clinical evidence would be required." +7544699,Ciprofloxacin treats diarrheal disease,1366,The aim of this study was to investigate clinical importance of ciprofloxacin efficacy in treatment of massive diarrhoea in patients after extensional bowel resection with removing of ileo-coecal valve (EBR + ICVR).,False,Is the triple 'Ciprofloxacin treats diarrheal disease' supported by the sentence: 'The aim of this study was to investigate clinical importance of ciprofloxacin efficacy in treatment of massive diarrhoea in patients after extensional bowel resection with removing of ileo-coecal valve (EBR + ICVR).'?,"No, it is not directly nor indirectly supported, as the given statement is about a clinical investigation into ciprofloxacin's efficacy in treating massive diarrhoea after a specific type of bowel surgery, not about ciprofloxacin treating diarrhoeal diseases in general." +7423320,Ciprofloxacin treats typhoid fever,1367,"To compare clinical and bacteriological efficacies of azithromycin and ciprofloxacin for typhoid fever, 123 adults with fever and signs of uncomplicated typhoid fever were entered into a randomized trial.",True,"Is the triple 'Ciprofloxacin treats typhoid fever' supported by the sentence: 'To compare clinical and bacteriological efficacies of azithromycin and ciprofloxacin for typhoid fever, 123 adults with fever and signs of uncomplicated typhoid fever were entered into a randomized trial.'?","Yes, it is indirectly supported because it mentions a randomized trial comparing azithromycin and ciprofloxacin for treating uncomplicated typhoid fever, suggesting that ciprofloxacin is indeed used for treating this disease." +7337248,Ciprofloxacin treats pneumonia,1368,Initial treatment of severe pneumonia with ciprofloxacin resulted in significantly less subsequent gram-negative infection and was associated with substantially lower curative costs.,True,Is the triple 'Ciprofloxacin treats pneumonia' supported by the sentence: 'Initial treatment of severe pneumonia with ciprofloxacin resulted in significantly less subsequent gram-negative infection and was associated with substantially lower curative costs.'?,"Yes, it is indirectly supported because if ciprofloxacin is effective in treating severe pneumonia, as suggested in the second sentence, then it could be inferred that ciprofloxacin indeed has some positive effect on treating pneumonia, as stated in the first sentence, albeit in a more serious form (severe). However, it's important to note that this is an inference based on a single statement, so it may not be universally applicable in all cases of pneumonia, nor is it a direct statement about ciprofloxacin treating 'all' types of pneumonia, just 'severe' pneumonia as per the context given in your statement." +7228759,Ciprofloxacin treats infectious disease,1369,"Ciprofloxacin (CIP), a fluoroquinolone antibacterial drug, is widely used in the treatment of serious infections in humans.",True,"Is the triple 'Ciprofloxacin treats infectious disease' supported by the sentence: 'Ciprofloxacin (CIP), a fluoroquinolone antibacterial drug, is widely used in the treatment of serious infections in humans.'?","Yes, it is indirectly supported because Ciprofloxacin is an antibacterial drug used in treating serious infections, which implies that it helps in treating infectious diseases." +7163480,Ciprofloxacin treats Crohn disease,1370,Use of antibiotics in the treatment of active Crohn's disease: experience with metronidazole and ciprofloxacin.,True,Is the triple 'Ciprofloxacin treats Crohn disease' supported by the sentence: 'Use of antibiotics in the treatment of active Crohn's disease: experience with metronidazole and ciprofloxacin.'?,"Yes, it is indirectly supported because the title mentions both ciprofloxacin and its use in treating active Crohn's disease, even though it does not explicitly confirm that ciprofloxacin is used to treat Crohn's disease directly (it could be treating a symptom, for example)." +10607698,Chloramphenicol treats bacterial infectious disease,1371,[Experiences with a chloramphenicol preparation for intramuscular injection in bacterial infections of the CNS].,True,Is the triple 'Chloramphenicol treats bacterial infectious disease' supported by the sentence: '[Experiences with a chloramphenicol preparation for intramuscular injection in bacterial infections of the CNS].'?,"Yes, it is indirectly supported because it mentions the use of Chloramphenicol in treating bacterial infections, specifically infections of the Central Nervous System (CNS). However, it does not explicitly state that Chloramphenicol is used to treat all types of bacterial infections, nor does it mention that Chloramphenicol is used to treat infections caused by antibiotic-resistant bacteria, which is one of the main uses of Chloramphenicol in modern medicine due to its broad-spectrum antibiotic properties." +9528501,Chloramphenicol treats osteomyelitis,1372,A 2-month-old infant with Enterobacter osteomyelitis complicating total parenteral nutrition was successfully treated with rifampicin and chloramphenicol.,True,Is the triple 'Chloramphenicol treats osteomyelitis' supported by the sentence: 'A 2-month-old infant with Enterobacter osteomyelitis complicating total parenteral nutrition was successfully treated with rifampicin and chloramphenicol.'?,"Yes, it is indirectly supported because chloramphenicol was used to treat an instance of osteomyelitis caused by Enterobacter, which is a type of bacteria sensitive to chloramphenicol, as per the given statement." +7351604,Chloramphenicol treats eye infectious disorder,1373,"The writers consult a wide range of American, European and British research from 1950 to the present to reassure readers that ophthalmic chloramphenicol is a demonstrably effective, safe, cost-effective treatment for most superficial eye infections.",True,"Is the triple 'Chloramphenicol treats eye infectious disorder' supported by the sentence: 'The writers consult a wide range of American, European and British research from 1950 to the present to reassure readers that ophthalmic chloramphenicol is a demonstrably effective, safe, cost-effective treatment for most superficial eye infections.'?","Yes, it is indirectly supported because the given statement mentions that ophthalmic chloramphenicol is an effective treatment for most superficial eye infections, which includes various types of bacterial infections that can be treated with chloramphenicol. However, it does not explicitly mention 'eye infectious disorders' but it does cover bacterial infections which can be considered as 'eye infectious disorders'." +24500158,Rebamipide treats gastroesophageal reflux disease,1374,Frequently reported adverse events of rebamipide compared to other drugs for peptic ulcer and gastroesophageal reflux disease.,False,Is the triple 'Rebamipide treats gastroesophageal reflux disease' supported by the sentence: 'Frequently reported adverse events of rebamipide compared to other drugs for peptic ulcer and gastroesophageal reflux disease.'?,"No, it is not directly supported because the given sentence does not mention that rebamipide specifically treats gastroesophageal reflux disease (GERD). It only states that rebamipide has frequently reported adverse events compared to other drugs for peptic ulcer and GERD, but it does not confirm that rebamipide itself is used to treat GERD." +19949890,Rebamipide treats osteoarthritis,1375,We also discuss the potential role of rebamipide to serve as a new strategy for the treatment of TMJ-OA.,True,Is the triple 'Rebamipide treats osteoarthritis' supported by the sentence: 'We also discuss the potential role of rebamipide to serve as a new strategy for the treatment of TMJ-OA.'?,"Yes, it is indirectly supported because both statements refer to Rebamipide being used in a treatment context, in this case for TMJ-OA (Temporomandibular Joint Osteoarthritis), which is a form of osteoarthritis. However, it's important to note that direct support would require a more explicit statement linking Rebamipide directly to treating general osteoarthritis, not just a specific form." +19364844,Rebamipide treats dry eye syndrome,1376,CONCLUSIONS: REB and DQS may be effective for the management of dry eye syndrome after PK in terms of ocular surface findings.,True,Is the triple 'Rebamipide treats dry eye syndrome' supported by the sentence: 'CONCLUSIONS: REB and DQS may be effective for the management of dry eye syndrome after PK in terms of ocular surface findings.'?,"Yes, it is indirectly supported because both sentences discuss the positive effects of Rebamipide on treating dry eye syndrome, albeit in different contexts (after PK in this case)." +13211904,Rebamipide treats ulcerative colitis,1377,"OBJECTIVE AND DESIGN: Since rebamipide is effective for the treatment of ulcerative colitis (UC), we examined the involvement of hepatocyte growth factor (HGF) in the action of rebamipide.",True,"Is the triple 'Rebamipide treats ulcerative colitis' supported by the sentence: 'OBJECTIVE AND DESIGN: Since rebamipide is effective for the treatment of ulcerative colitis (UC), we examined the involvement of hepatocyte growth factor (HGF) in the action of rebamipide.'?","Yes, the statement does provide indirect support for the claim that Rebamipide treats ulcerative colitis (UC). It mentions that Rebamipide is effective for UC treatment, which implies that it has a therapeutic effect on UC. However, it does not directly demonstrate that Rebamipide treats ulcerative colitis, but rather implies it based on its effectiveness, thus making it an indirect form of support." +12062800,Rebamipide treats peptic ulcer disease,1378,"Rebamipide, a gastro-protective drug, was developed in Japan for the treatment of peptic ulcer disease.",True,"Is the triple 'Rebamipide treats peptic ulcer disease' supported by the sentence: 'Rebamipide, a gastro-protective drug, was developed in Japan for the treatment of peptic ulcer disease.'?","Yes, it is indirectly supported because Rebamipide is identified as a drug used for treating peptic ulcer disease in both sentences, although it doesn't explicitly state that Rebamipide is used to treat peptic ulcers in all cases." +10368387,Rebamipide treats gastric ulcer,1379,Rebamipide is a mucoprotective drug used for the treatment of gastric ulcers.,True,Is the triple 'Rebamipide treats gastric ulcer' supported by the sentence: 'Rebamipide is a mucoprotective drug used for the treatment of gastric ulcers.'?,"Yes, it is indirectly supported. The statement that Rebamipide is a mucoprotective drug used for the treatment of gastric ulcers implies that it has therapeutic effects on gastric ulcers, which aligns with the claim that it treats gastric ulcers." +8102739,Rebamipide treats gastritis,1380,"In conclusion, rebamipide may attenuate H. pylori-induced gastric inflammation by inhibiting lipid peroxidation and oxidant-mediated activation of NF-kappaB and thereby decreasing IL-8 production.",True,"Is the triple 'Rebamipide treats gastritis' supported by the sentence: 'In conclusion, rebamipide may attenuate H. pylori-induced gastric inflammation by inhibiting lipid peroxidation and oxidant-mediated activation of NF-kappaB and thereby decreasing IL-8 production.'?","Yes. The statement suggests that rebamipide can inhibit lipid peroxidation and oxidant-mediated activation of NF-kappaB, which in turn decreases IL-8 production. Since IL-8 is a pro-inflammatory cytokine associated with gastric inflammation, this implies that rebamipide could potentially treat gastritis (H. pylori-induced in this case). Therefore, there is an indirect support for the claim that 'rebamipide treats gastritis'." +27610972,DINUTUXIMAB treats bone osteosarcoma,1381,Phase I trial of a human-mouse chimeric anti-disialoganglioside monoclonal antibody ch14.18 in patients with refractory neuroblastoma and osteosarcoma.,False,Is the triple 'DINUTUXIMAB treats bone osteosarcoma' supported by the sentence: 'Phase I trial of a human-mouse chimeric anti-disialoganglioside monoclonal antibody ch14.18 in patients with refractory neuroblastoma and osteosarcoma.'?,"No, it is not directly supported because it mentions neuroblastoma, not multiple myeloma, in relation to DINUTUXIMAB treatment, but it does suggest that DINUTUXIMAB may be used in clinical trials for treating refractory osteosarcomas, thus providing an indirect link to bone-related cancers." +21740095,DINUTUXIMAB treats neoplasm,1382,Tumors treated with local dinutuximab had decreased MYCN expression on histology compared to control or IgG-treated tumors.,True,Is the triple 'DINUTUXIMAB treats neoplasm' supported by the sentence: 'Tumors treated with local dinutuximab had decreased MYCN expression on histology compared to control or IgG-treated tumors.'?,"Yes, it is indirectly supported because decreased MYCN expression on histology can indicate a positive response to treatment, which suggests that Dinutuximab has an effect on treating tumors (neoplasms). However, it's important to note that this is an indirect inference based on a single piece of evidence, and further research would be needed to confirm this conclusion." +9445080,DINUTUXIMAB treats neuroblastoma,1383,Ocular symptoms in children treated with human-mouse chimeric anti-GD2 mAb ch14.18 for neuroblastoma.,False,Is the triple 'DINUTUXIMAB treats neuroblastoma' supported by the sentence: 'Ocular symptoms in children treated with human-mouse chimeric anti-GD2 mAb ch14.18 for neuroblastoma.'?,"No, it is not directly or indirectly supported, as there is no mention of DINUTUXIMAB, which is a specific type of anti-GD2 monoclonal antibody used for treating neuroblastoma, nor any comparison to it, just a reference to a type of anti-GD2 therapy being used for treating ocular symptoms in children with neuroblastoma." +22808973,BRENTUXIMAB VEDOTIN treats anaplastic large cell lymphoma,1384,[Brentuximab vedotin for previously untreated systemic anaplastic large cell lymphoma].,True,Is the triple 'BRENTUXIMAB VEDOTIN treats anaplastic large cell lymphoma' supported by the sentence: '[Brentuximab vedotin for previously untreated systemic anaplastic large cell lymphoma].'?,"Yes, the statement ""[Brentuximab vedotin for previously untreated systemic anaplastic large cell lymphoma]."" does support, either directly or indirectly, that Brentuximab vedotin treats anaplastic large cell lymphoma, as it mentions its use in previously untreated systemic anaplastic large cell lymphoma." +22284390,BRENTUXIMAB VEDOTIN treats neoplasm,1385,"Although brentuximab-vedotin (BV) demonstrated single-agent activity, tumours regrew during BV therapy.",True,"Is the triple 'BRENTUXIMAB VEDOTIN treats neoplasm' supported by the sentence: 'Although brentuximab-vedotin (BV) demonstrated single-agent activity, tumours regrew during BV therapy.'?","Yes, it is indirectly supported. The statement suggests that while BV has shown some effectiveness in treating tumors, it has not provided a lasting solution as tumors have regrown during therapy, indicating that BV may not be a comprehensive treatment for neoplasms (a type of abnormal tissue growth often associated with cancer). However, it does not directly state that BV treats neoplasms, but rather implies it based on its observed effects." +21657991,BRENTUXIMAB VEDOTIN treats mature T-cell and NK-cell non-Hodgkin lymphoma,1386,BV is a major therapeutic advance in the treatment of patients with R/R CTCL and of those with PTCL in both the R/R and frontline settings.,True,Is the triple 'BRENTUXIMAB VEDOTIN treats mature T-cell and NK-cell non-Hodgkin lymphoma' supported by the sentence: 'BV is a major therapeutic advance in the treatment of patients with R/R CTCL and of those with PTCL in both the R/R and frontline settings.'?,"Yes, it is indirectly supported, as Brentuximab Vedotin (BV) is mentioned as a major therapeutic advance in treating Relapsed/Refractory Cutaneous T-Cell Lymphoma (CTCL) and Peripheral T-Cell Lymphomas (PTCL), which fall under the category of mature T-cell and NK-cell non-Hodgkin lymphomas." +21657990,BRENTUXIMAB VEDOTIN treats primary cutaneous T-cell non-Hodgkin lymphoma,1387,BV is a major therapeutic advance in the treatment of patients with R/R CTCL and of those with PTCL in both the R/R and frontline settings.,True,Is the triple 'BRENTUXIMAB VEDOTIN treats primary cutaneous T-cell non-Hodgkin lymphoma' supported by the sentence: 'BV is a major therapeutic advance in the treatment of patients with R/R CTCL and of those with PTCL in both the R/R and frontline settings.'?,"Yes, it is supported. The sentence mentions that BV (Brentuximab Vedotin) is effective in treating R/R CTCL (Relapsed/Refractory Cutaneous T-Cell Lymphoma) and frontline PTCL (Peripheral T-Cell Lymphoma), which includes Primary Cutaneous T-Cell Non-Hodgkin Lymphoma (PTCL NHL). Therefore, it can be inferred that BV is used to treat PTCL NHL, even though it is not explicitly stated in the sentence." +21596847,BRENTUXIMAB VEDOTIN treats Sezary syndrome,1388,"[Ulceration of lymphomatous skin lesions in a patient with Sezary syndrome treated with brentuximab-vedotin].BACKGROUND: Brentuximab-vedotin (BV), an anti-CD30 agent combined with an anti-neoplastic agent, has recently yielded promising results in the treatment of cutaneous T-lymphomas such as Sezary syndrome.",True,"Is the triple 'BRENTUXIMAB VEDOTIN treats Sezary syndrome' supported by the sentence: '[Ulceration of lymphomatous skin lesions in a patient with Sezary syndrome treated with brentuximab-vedotin].BACKGROUND: Brentuximab-vedotin (BV), an anti-CD30 agent combined with an anti-neoplastic agent, has recently yielded promising results in the treatment of cutaneous T-lymphomas such as Sezary syndrome.'?","Yes, it is indirectly supported because it mentions that Brentuximab-vedotin (BV) has shown promising results in treating cutaneous T-cell lymphomas, which includes Sezary syndrome, but it does not explicitly state that BV treats Sezary syndrome." +21569598,BRENTUXIMAB VEDOTIN treats adult T-cell leukemia/lymphoma,1389,Further investigations on the use of brentuximab vedotin for adult T-cell leukemia/lymphoma are needed.,True,Is the triple 'BRENTUXIMAB VEDOTIN treats adult T-cell leukemia/lymphoma' supported by the sentence: 'Further investigations on the use of brentuximab vedotin for adult T-cell leukemia/lymphoma are needed.'?,"Yes, it is indirectly supported because further investigations imply that there is potential for brentuximab vedotin to treat adult T-cell leukemia/lymphoma, but it is not yet proven or established." +21569593,BRENTUXIMAB VEDOTIN treats lymphoma,1390,Brentuximab vedotin represents a major breakthrough in the treatment of CD30-positive lymphomas.,True,Is the triple 'BRENTUXIMAB VEDOTIN treats lymphoma' supported by the sentence: 'Brentuximab vedotin represents a major breakthrough in the treatment of CD30-positive lymphomas.'?,"Yes, it is. The statement ""Brentuximab vedotin represents a major breakthrough in the treatment of CD30-positive lymphomas"" implies that Brentuximab vedotin is an effective treatment for certain types of lymphomas, which aligns with the claim that it treats lymphoma, even though it doesn't explicitly mention all three terms together." +21525451,BRENTUXIMAB VEDOTIN treats Hodgkins lymphoma,1391,"Currently, ADCs that have received regulatory approval include brentuximab vedotin for CD30-positive Hodgkin lymphoma and trastuzumab emtansine for human epidermal growth factor receptor 2-positive breast cancer.",True,"Is the triple 'BRENTUXIMAB VEDOTIN treats Hodgkins lymphoma' supported by the sentence: 'Currently, ADCs that have received regulatory approval include brentuximab vedotin for CD30-positive Hodgkin lymphoma and trastuzumab emtansine for human epidermal growth factor receptor 2-positive breast cancer.'?","Yes, it is indirectly supported. The sentence mentions that brentuximab vedotin is approved for CD30-positive Hodgkin lymphoma, which implies that it is used to treat this type of cancer." +21472937,BRENTUXIMAB VEDOTIN treats mycosis fungoides,1392,The interest of BV in the management of CD30-positive mycosis fungoides (MF) and primary cutaneous anaplastic large cell lymphoma has recently been demonstrated compared to methotrexate or bexarotene.,True,Is the triple 'BRENTUXIMAB VEDOTIN treats mycosis fungoides' supported by the sentence: 'The interest of BV in the management of CD30-positive mycosis fungoides (MF) and primary cutaneous anaplastic large cell lymphoma has recently been demonstrated compared to methotrexate or bexarotene.'?,"Yes, it is. The statement mentions that Brentuximab Vedotin (abbreviated as BV) has shown interest in managing CD30-positive mycosis fungoides (MF), which implies that it is a treatment option for this condition. Therefore, it can be inferred that BV does treat mycosis fungoides, even though it may not be explicitly stated in the provided sentence." +22346012,Tetracycline treats Infection,1393,"The following antimicrobials commonly used for the treatment of C.difficile infections or applied previously in C.difficile epidemiological studies were tested: metronidazole, vancomycin, meropenem, ceftriaxone, ampicillin-sulbactam, clindamycin, erythromycin, moxifloxacin, tetracycline, doxycycline, tigecycline and linezolid.",True,"Is the triple 'Tetracycline treats Infection' supported by the sentence: 'The following antimicrobials commonly used for the treatment of C.difficile infections or applied previously in C.difficile epidemiological studies were tested: metronidazole, vancomycin, meropenem, ceftriaxone, ampicillin-sulbactam, clindamycin, erythromycin, moxifloxacin, tetracycline, doxycycline, tigecycline and linezolid.'?","Yes, it is indirectly supported because tetracycline is listed as one of the antibiotics tested, which suggests that it is considered a potential treatment for C.difficile infections, even though it may not be as common as others like metronidazole, vancomycin, etc." +15910237,Tetracycline treats eye infectious disorder,1394,"In addition, resistance to azithromycin, erythromycin, tetracycline, and trimethoprim was greater than 10%, which may be relevant when selecting empiric treatments for ocular surface infections.",True,"Is the triple 'Tetracycline treats eye infectious disorder' supported by the sentence: 'In addition, resistance to azithromycin, erythromycin, tetracycline, and trimethoprim was greater than 10%, which may be relevant when selecting empiric treatments for ocular surface infections.'?","Yes, it is indirectly supported because it mentions that tetracycline has developed a level of resistance greater than 10%, which may be relevant when choosing empirical treatments for ocular surface infections. This implies that tetracycline can be used for treating ocular surface infections but its efficacy may be compromised due to its high resistance rate." +10596737,Tetracycline treats osteomyelitis,1395,[Clinical considerations on the topical use of a new hydrosoluble tetracycline derivative in chronic osteomyelitis].,True,Is the triple 'Tetracycline treats osteomyelitis' supported by the sentence: '[Clinical considerations on the topical use of a new hydrosoluble tetracycline derivative in chronic osteomyelitis].'?,"Yes, it is indirectly supported. The title suggests that this study discusses the use of a new derivative of Tetracycline in treating chronic osteomyelitis, implying that Tetracycline itself could be used for this purpose. However, it's important to note that direct evidence of Tetracycline treating osteomyelitis isn't provided in this title alone, hence it's an indirect support." +10513439,Tetracycline treats bacterial infectious disease,1396,Nystatin and tetracycline in the treatment of bacterial infections.,True,Is the triple 'Tetracycline treats bacterial infectious disease' supported by the sentence: 'Nystatin and tetracycline in the treatment of bacterial infections.'?,"Yes, it is indirectly supported because it mentions Tetracycline being used in the treatment of bacterial infections, which aligns with the statement that Tetracycline is used to treat bacterial diseases. However, it does not explicitly state that Tetracycline is used to treat diseases caused by bacteria, which is what the original statement implies." +10332719,Tetracycline treats periodontitis,1397,Meta-analysis of local tetracycline in treating chronic periodontitis.,True,Is the triple 'Tetracycline treats periodontitis' supported by the sentence: 'Meta-analysis of local tetracycline in treating chronic periodontitis.'?,"Yes, it is indirectly supported because both sentences refer to Tetracycline being used to treat some form of gum disease, which is a type of periodontitis. However, it's important to note that the second sentence is a reference to a meta-analysis, which is a study that combines and analyzes data from multiple studies, specifically focusing on local (not systemic) Tetracycline use for chronic periodontitis, not all forms of periodontitis as suggested by your first statement." +7227539,Tetracycline treats Helicobacter pylori infectious disease,1398,"Ranitidine bismuth citrate, tetracycline, clarithromycin twice-a-day triple therapy for clarithromycin susceptible Helicobacter pylori infection.",True,"Is the triple 'Tetracycline treats Helicobacter pylori infectious disease' supported by the sentence: 'Ranitidine bismuth citrate, tetracycline, clarithromycin twice-a-day triple therapy for clarithromycin susceptible Helicobacter pylori infection.'?","Yes, the statement is indirectly supported because it mentions tetracycline as part of a triple therapy to treat a clarithromycin susceptible Helicobacter pylori infection, which implies that tetracycline is used to treat this type of infection." +22788639,(Alginate)n treats Pain,1399,"With these results, we propose alginate-based nanoemulsions as a potential treatment for migraine pain.",True,"Is the triple '(Alginate)n treats Pain' supported by the sentence: 'With these results, we propose alginate-based nanoemulsions as a potential treatment for migraine pain.'?","Yes, it is indirectly supported because both statements suggest that alginate could be used in a treatment for pain relief, specifically for migraines in this case." +11016107,(Alginate)n treats gastroesophageal reflux disease,1400,An open multicenter study was performed to assess the efficacy and safety of alginic acid in two different dosages in 76 pediatric patients with gastroesophageal reflux confirmed by pH monitoring.,True,Is the triple '(Alginate)n treats gastroesophageal reflux disease' supported by the sentence: 'An open multicenter study was performed to assess the efficacy and safety of alginic acid in two different dosages in 76 pediatric patients with gastroesophageal reflux confirmed by pH monitoring.'?,"Yes, this statement does provide support for the use of alginic acid (a component of alginate) in treating gastroesophageal reflux disease (GERD). The study mentioned was conducted on pediatric patients with GERD confirmed by pH monitoring, and it aimed to assess the efficacy and safety of alginic acid in two different dosages. Therefore, it suggests that alginic acid can have a role in treating GERD, even if not directly addressing the specific formulation ""(Alginate)n""." +22283339,Chlorhexidine treats Peri-Implantitis,1401,There is a need for more homogenous RCTs with large sample size to define the role of CHX in non-surgical management of peri-implant mucositis and peri-implantitis.,True,Is the triple 'Chlorhexidine treats Peri-Implantitis' supported by the sentence: 'There is a need for more homogenous RCTs with large sample size to define the role of CHX in non-surgical management of peri-implant mucositis and peri-implantitis.'?,"Yes, it can be interpreted as indirect support. The statement suggests that there is a lack of sufficient research to definitively establish Chlorhexidine's role in managing peri-implant mucositis and peri-implantitis, implying that further research could potentially support its use in non-surgical management of these conditions." +14556561,Chlorhexidine treats pneumonia,1402,"Among patients without pneumonia at baseline, pneumonia developed in 24% (CPIS >or=6) by day 3 in those treated with chlorhexidine.",True,"Is the triple 'Chlorhexidine treats pneumonia' supported by the sentence: 'Among patients without pneumonia at baseline, pneumonia developed in 24% (CPIS >or=6) by day 3 in those treated with chlorhexidine.'?","Yes, it is indirectly supported. The statement suggests that chlorhexidine treatment is associated with an increased risk of developing pneumonia within three days in patients who did not have it at baseline. However, it does not directly state that chlorhexidine treats pneumonia." +14034776,Chlorhexidine treats dental caries,1403,"Sodium fluoride and chlorhexidine effect in the inhibition of mutans streptococci in children with dental caries: a randomized, double-blind clinical trial.",True,"Is the triple 'Chlorhexidine treats dental caries' supported by the sentence: 'Sodium fluoride and chlorhexidine effect in the inhibition of mutans streptococci in children with dental caries: a randomized, double-blind clinical trial.'?","Yes, it is indirectly supported. The given sentence mentions that Chlorhexidine is used in a clinical trial involving children with dental caries, which implies that Chlorhexidine is used as a treatment for dental caries, even if not directly stated in this particular sentence." +13966318,Chlorhexidine treats bacterial infectious disease with sepsis,1404,"All patients with B. stabilis bacteraemia had indwelling intravenous catheters, which were treated with chlorhexidine to disinfect the catheters.",True,"Is the triple 'Chlorhexidine treats bacterial infectious disease with sepsis' supported by the sentence: 'All patients with B. stabilis bacteraemia had indwelling intravenous catheters, which were treated with chlorhexidine to disinfect the catheters.'?","Yes, it is indirectly supported. The statement mentions that chlorhexidine was used to disinfect catheters in patients with a specific type of bacteremia, implying that chlorhexidine may have a role in treating bacterial infections, which could include those causing sepsis. However, it does not directly state that chlorhexidine is used to treat bacterial infections causing sepsis." +13955725,Chlorhexidine treats bacterial infectious disease,1405,Chlorhexidine (CHX) is effective in treating oral bacterial infections.,True,Is the triple 'Chlorhexidine treats bacterial infectious disease' supported by the sentence: 'Chlorhexidine (CHX) is effective in treating oral bacterial infections.'?,"Yes, it is indirectly supported because Chlorhexidine is a substance used to treat oral bacterial infections, which implies it has some effect on bacteria, thus potentially supporting its use in treating other types of bacterial infections as well, though not explicitly stated in the second sentence." +13614413,Chlorhexidine treats stomatitis,1406,CONCLUSIONS: The frequency and duration of OM are significantly improved by prophylactic chlorhexidine and by cryotherapy.,True,Is the triple 'Chlorhexidine treats stomatitis' supported by the sentence: 'CONCLUSIONS: The frequency and duration of OM are significantly improved by prophylactic chlorhexidine and by cryotherapy.'?,"Yes, it is indirectly supported because prophylactic chlorhexidine is shown to improve the frequency and duration of oral mucositis (OM), which could include stomatitis, as they are similar conditions affecting the oral mucosa." +12567084,Chlorhexidine treats infectious disease,1407,"We developed an efficacious and non-irritant mouthwash that is alcohol-free and that has a low concentration of chlorhexidine, in order to be used for preventing oral cavity infections in immunocompromised and cancer patients.",True,"Is the triple 'Chlorhexidine treats infectious disease' supported by the sentence: 'We developed an efficacious and non-irritant mouthwash that is alcohol-free and that has a low concentration of chlorhexidine, in order to be used for preventing oral cavity infections in immunocompromised and cancer patients.'?","Yes, it is indirectly supported, as it mentions a mouthwash with a low concentration of chlorhexidine, which is used for preventing oral cavity infections, which can be a form of infectious disease, especially in immunocompromised and cancer patients who may be more susceptible to such infections." +12447822,Chlorhexidine treats Neonatal sepsis,1408,"However, 2 large but not randomized studies, one in Malawi and the other in Egypt, suggest that important reductions in maternal and neonatal sepsis and neonatal mortality may be achievable with vaginal or neonatal chlorhexidine treatment.",True,"Is the triple 'Chlorhexidine treats Neonatal sepsis' supported by the sentence: 'However, 2 large but not randomized studies, one in Malawi and the other in Egypt, suggest that important reductions in maternal and neonatal sepsis and neonatal mortality may be achievable with vaginal or neonatal chlorhexidine treatment.'?","Yes, it is indirectly supported because it mentions that chlorhexidine treatment can lead to reductions in maternal and neonatal sepsis and neonatal mortality, which implies a potential treatment for neonatal sepsis." +11792004,Chlorhexidine treats periodontal disorder,1409,BACKGROUND: Tooth staining is a common feature of chlorhexidine treatment for periodontal disease and there is a large variation between patients as to the degree of their tooth staining.,True,Is the triple 'Chlorhexidine treats periodontal disorder' supported by the sentence: 'BACKGROUND: Tooth staining is a common feature of chlorhexidine treatment for periodontal disease and there is a large variation between patients as to the degree of their tooth staining.'?,"Yes, it is indirectly supported. The background information suggests that chlorhexidine treatment for periodontal disease can result in tooth staining, which implies that chlorhexidine does have an effect on periodontal disease. However, it doesn't directly state that chlorhexidine treats periodontal disorders, but rather highlights a common side effect of its use." +10593306,Chlorhexidine treats eye infectious disorder,1410,Clinical trial of chlorhexidine and diaminodiphenylsulphone in superficial ocular infections.,True,Is the triple 'Chlorhexidine treats eye infectious disorder' supported by the sentence: 'Clinical trial of chlorhexidine and diaminodiphenylsulphone in superficial ocular infections.'?,"Yes, it is indirectly supported. The title suggests that a clinical trial was conducted to test the effectiveness of Chlorhexidine, among other substances, in treating superficial ocular infections, which includes various types of eye infections." +7869752,Chlorhexidine treats gingivitis,1411,"The abrasiveness of the chew, rather than the antibacterial activity of chlorhexidine, is likely to have contributed the most to the maintenance of oral health in dogs with mild gingivitis.",False,"Is the triple 'Chlorhexidine treats gingivitis' supported by the sentence: 'The abrasiveness of the chew, rather than the antibacterial activity of chlorhexidine, is likely to have contributed the most to the maintenance of oral health in dogs with mild gingivitis.'?","No. The statement suggests that chlorhexidine's antibacterial activity may not be the primary factor in maintaining oral health in dogs with mild gingivitis, contrary to the claim that chlorhexidine treats gingivitis." +7287519,Chlorhexidine treats periodontitis,1412,Assessing the effectiveness of locally delivered chlorhexidine in the treatment of periodontitis.,True,Is the triple 'Chlorhexidine treats periodontitis' supported by the sentence: 'Assessing the effectiveness of locally delivered chlorhexidine in the treatment of periodontitis.'?,"Yes, it is indirectly supported because assessing the effectiveness implies that there is a potential positive outcome, which aligns with treating a condition like periodontitis in this case." +7281939,Chlorhexidine treats Acanthamoeba keratitis,1413,Treatment of acanthamoeba keratitis with chlorhexidine.,True,Is the triple 'Chlorhexidine treats Acanthamoeba keratitis' supported by the sentence: 'Treatment of acanthamoeba keratitis with chlorhexidine.'?,"Yes, the statement ""Chlorhexidine treats Acanthamoeba keratitis"" is indirectly supported by the sentence ""Treatment of acanthamoeba keratitis with chlorhexidine."" This is because treating a condition with a specific substance implies that the substance is effective against that condition, which is what 'treats' means in this context." +22179313,Nicergoline treats depressive disorder,1414,"The Efficacy of Sertraline, Escitalopram, and Nicergoline in the Treatment of Depression and Apathy in Alzheimer's Disease: The Okayama Depression and Apathy Project (ODAP).BACKGROUND: Neuropsychiatric symptoms of dementia such as depression and apathy in patients with Alzheimer's disease (AD) are associated with a lower quality of life.",True,"Is the triple 'Nicergoline treats depressive disorder' supported by the sentence: 'The Efficacy of Sertraline, Escitalopram, and Nicergoline in the Treatment of Depression and Apathy in Alzheimer's Disease: The Okayama Depression and Apathy Project (ODAP).BACKGROUND: Neuropsychiatric symptoms of dementia such as depression and apathy in patients with Alzheimer's disease (AD) are associated with a lower quality of life.'?","Yes, it is indirectly supported because Nicergoline is mentioned as being a part of a study on treating depression and apathy in Alzheimer's disease patients along with Sertraline and Escitalopram. However, it does not directly state that Nicergoline specifically treats depressive disorders in humans." +9203015,Nicergoline treats dementia,1415,"OBJECTIVES: To determine whether there is evidence of efficacy of nicergoline in the treatment of dementia and other age-associated forms of cognitive decline,and to assess the safety and tolerability of the drug.",True,"Is the triple 'Nicergoline treats dementia' supported by the sentence: 'OBJECTIVES: To determine whether there is evidence of efficacy of nicergoline in the treatment of dementia and other age-associated forms of cognitive decline,and to assess the safety and tolerability of the drug.'?","Yes, the statement you provided does suggest that nicergoline may be used in the treatment of dementia and other age-associated forms of cognitive decline, which aligns with the claim that nicergoline treats dementia, at least indirectly. However, it's important to note that this statement does not confirm that nicergoline definitively treats dementia, but rather that it's being studied for such use." +22026892,RAMUCIRUMAB treats adenocarcinoma,1416,"Methods: In this retrospective two-center study, 56 patients with metastatic gastric cancer (47%) or adenocarcinoma of the GEJ (53%) were treated with paclitaxel and ramucirumab (n=38) as second-line (75%) or beyond second-line (25%) therapy.",True,"Is the triple 'RAMUCIRUMAB treats adenocarcinoma' supported by the sentence: 'Methods: In this retrospective two-center study, 56 patients with metastatic gastric cancer (47%) or adenocarcinoma of the GEJ (53%) were treated with paclitaxel and ramucirumab (n=38) as second-line (75%) or beyond second-line (25%) therapy.'?","Yes, it is indirectly supported because the mentioned study includes patients with metastatic gastric cancer or adenocarcinoma of the GEJ who were treated with ramucirumab, suggesting its use in treating adenocarcinoma. However, it does not directly state that ramucirumab treats adenocarcinoma, but rather that it is used in its treatment in certain contexts (second-line or beyond second-line therapy)." +21622108,RAMUCIRUMAB treats non-small cell lung carcinoma,1417,This study aimed to validate the primary prophylactic use of pegfilgrastim with docetaxel and ramucirumab treatment in Japanese patients with NSCLC.,True,Is the triple 'RAMUCIRUMAB treats non-small cell lung carcinoma' supported by the sentence: 'This study aimed to validate the primary prophylactic use of pegfilgrastim with docetaxel and ramucirumab treatment in Japanese patients with NSCLC.'?,"Yes, it is indirectly supported because it mentions ramucirumab treatment in relation to non-small cell lung cancer (NSCLC). However, it doesn't explicitly state that ramucirumab treats NSCLC, but rather it's being used in a treatment regimen for NSCLC patients." +21474987,RAMUCIRUMAB treats hepatocellular carcinoma,1418,Cost-effectiveness analysis of ramucirumab treatment for patients with hepatocellular carcinoma who progressed on sorafenib with alpha-fetoprotein concentrations of at least 400 ng/ml.,True,Is the triple 'RAMUCIRUMAB treats hepatocellular carcinoma' supported by the sentence: 'Cost-effectiveness analysis of ramucirumab treatment for patients with hepatocellular carcinoma who progressed on sorafenib with alpha-fetoprotein concentrations of at least 400 ng/ml.'?,"Yes, it is indirectly supported because the statement mentions that ramucirumab is used in treatment for patients with hepatocellular carcinoma, although it doesn't explicitly state that ramucirumab treats hepatocellular carcinoma, it implies that it is a treatment option for this condition." +23342893,TAFASITAMAB treats diffuse large B-cell lymphoma,1419,Lenalidomide was recently approved in combination with the anti-monoclonal B-cell antibody tafasitamab for patients with relapsed DLBCL after 1 to 3 previous treatments.,True,Is the triple 'TAFASITAMAB treats diffuse large B-cell lymphoma' supported by the sentence: 'Lenalidomide was recently approved in combination with the anti-monoclonal B-cell antibody tafasitamab for patients with relapsed DLBCL after 1 to 3 previous treatments.'?,"Yes, it is supported. The approval of lenalidomide in combination with tafasitamab for patients with relapsed DLBCL (diffuse large B-cell lymphoma) after 1 to 3 previous treatments implies that tafasitamab is an effective treatment for DLBCL, thus providing indirect support to the statement that tafasitamab treats DLBCL." +22828138,Thioctic acid treats cystinuria,1420,Tolvaptan and a-Lipoic acid were also tested in patients with cystinuria and resulted in reduction of recurrence.,True,Is the triple 'Thioctic acid treats cystinuria' supported by the sentence: 'Tolvaptan and a-Lipoic acid were also tested in patients with cystinuria and resulted in reduction of recurrence.'?,"Yes, it is indirectly supported because both Thioctic acid (a form of Alpha Lipoic Acid) and Tolvaptan were tested in patients with Cystinuria, resulting in reduction of recurrence, which implies that Thioctic Acid could be an effective treatment for Cystinuria, just like Tolvaptan. However, it's important to note that further research is needed to confirm this implication, as this is based on an analogy between two treatments that have been tested in patients with Cystinuria." +21111424,Thioctic acid treats optic neuritis,1421,"Conclusion: Six weeks of oral lipoic acid supplementation after acute optic neuritis is safe and well tolerated; however, because of insufficient recruitment, we could not conclude that lipoic acid treatment was neuroprotective in acute optic neuritis.",True,"Is the triple 'Thioctic acid treats optic neuritis' supported by the sentence: 'Conclusion: Six weeks of oral lipoic acid supplementation after acute optic neuritis is safe and well tolerated; however, because of insufficient recruitment, we could not conclude that lipoic acid treatment was neuroprotective in acute optic neuritis.'?","Yes, it is indirectly supported because it states that six weeks of oral lipoic acid supplementation after acute optic neuritis is safe and well tolerated, indicating a potential positive effect, but it does not have enough data to confirm neuroprotective effects." +14414806,Thioctic acid treats carpal tunnel syndrome,1422,Treatment of carpal tunnel syndrome with alpha-lipoic acid.,True,Is the triple 'Thioctic acid treats carpal tunnel syndrome' supported by the sentence: 'Treatment of carpal tunnel syndrome with alpha-lipoic acid.'?,"Yes, it is indirectly supported because thioctic acid is another name for alpha-lipoic acid, so both statements refer to the same treatment for carpal tunnel syndrome." +11271151,Thioctic acid treats skin disorder,1423,Alpha-Lipoic acid-based PPARgamma agonists for treating inflammatory skin diseases.,True,Is the triple 'Thioctic acid treats skin disorder' supported by the sentence: 'Alpha-Lipoic acid-based PPARgamma agonists for treating inflammatory skin diseases.'?,"Yes, it is indirectly supported because Thioctic Acid is a form of Alpha-Lipoic Acid, which is being suggested as a potential treatment for inflammatory skin diseases through its role as a PPARgamma agonist. However, it's important to note that this is a complex topic and further research would be needed to fully support this claim." +9864403,Thioctic acid treats multiple sclerosis,1424,"For study of antioxidant therapy efficiency in relapsing-remitting multiple sclerosis we investigated group 1 (18 patients) treated with alpha-lipoic acid and group 2 (14 patients) who received complex of antioxidants and neuroprotectors with various mechanisms of action (oc-lipoic acid, Nicotinamide, Acetylcysteine, Triovit Beta-carotine, Alpha-tocopheryl acetate, Ascorbic acid, Selenium, Pentoxifylline, Cerebrolysin, Amantadine hydrochloride) during 1 month, 2 times a year.",False,"Is the triple 'Thioctic acid treats multiple sclerosis' supported by the sentence: 'For study of antioxidant therapy efficiency in relapsing-remitting multiple sclerosis we investigated group 1 (18 patients) treated with alpha-lipoic acid and group 2 (14 patients) who received complex of antioxidants and neuroprotectors with various mechanisms of action (oc-lipoic acid, Nicotinamide, Acetylcysteine, Triovit Beta-carotine, Alpha-tocopheryl acetate, Ascorbic acid, Selenium, Pentoxifylline, Cerebrolysin, Amantadine hydrochloride) during 1 month, 2 times a year.'?","No, this statement does not directly support that Thioctic Acid (also known as alpha-lipoic acid) treats multiple sclerosis. The statement mentions that a group of patients with relapsing-remitting multiple sclerosis were treated with alpha-lipoic acid, but it does not provide any information about the effectiveness of this treatment for multiple sclerosis." +8933101,Thioctic acid treats Alzheimer disease,1425,"Despite the fact that this study was small and not randomized, this is the first indication that treatment with alpha-lipoic acid might be a successful 'neuroprotective' therapy option for AD and related dementias.",True,"Is the triple 'Thioctic acid treats Alzheimer disease' supported by the sentence: 'Despite the fact that this study was small and not randomized, this is the first indication that treatment with alpha-lipoic acid might be a successful 'neuroprotective' therapy option for AD and related dementias.'?","Yes, it is indirectly supported because it mentions a possible positive effect of a compound (alpha-lipoic acid, also known as thioctic acid) on Alzheimer's Disease (AD) and related dementias, suggesting it might be a successful neuroprotective therapy option. However, it's important to note that more research is needed to confirm these findings due to the limitations of the study mentioned (small size and non-randomized)." +8739967,Thioctic acid treats hypertensive disorder,1426,"STZ-diabetes resulted in increased blood pressure, which was partially improved by alpha-lipoic acid treatment.",True,"Is the triple 'Thioctic acid treats hypertensive disorder' supported by the sentence: 'STZ-diabetes resulted in increased blood pressure, which was partially improved by alpha-lipoic acid treatment.'?","Yes, it is indirectly supported because alpha-lipoic acid, also known as thioctic acid, was found to partially improve increased blood pressure caused by diabetes, suggesting a potential beneficial effect on hypertensive disorders." +7865558,Thioctic acid treats type 2 diabetes mellitus,1427,"AIMS: Thioctic acid (TA), glibenclamide and acarbose are widely used to either alone or concomitantly treat patients suffering from noninsulin-dependent diabetes (NIDDM).",True,"Is the triple 'Thioctic acid treats type 2 diabetes mellitus' supported by the sentence: 'AIMS: Thioctic acid (TA), glibenclamide and acarbose are widely used to either alone or concomitantly treat patients suffering from noninsulin-dependent diabetes (NIDDM).'?","Yes, it is indirectly supported. The statement mentions that thioctic acid is used to treat noninsulin-dependent diabetes, which is another term for type 2 diabetes mellitus. However, it does not provide direct evidence of its effectiveness in treating this condition." +7603474,Thioctic acid treats diabetic neuropathy,1428,"A two-central randomised single-blind placebo-controlled study was conducted to assess efficacy of intravenous administration of trometamol salt of thioctic (alpha-lipoic) acid (Thioctacid 600, ""ASTA Medica"", Germany) in 200 ml of physiological solution in 40 non-insulin dependent diabetic patients with symptomatic diabetic neuropathy.",True,"Is the triple 'Thioctic acid treats diabetic neuropathy' supported by the sentence: 'A two-central randomised single-blind placebo-controlled study was conducted to assess efficacy of intravenous administration of trometamol salt of thioctic (alpha-lipoic) acid (Thioctacid 600, ""ASTA Medica"", Germany) in 200 ml of physiological solution in 40 non-insulin dependent diabetic patients with symptomatic diabetic neuropathy.'?","Yes, the statement does provide some level of support for the claim that thioctic acid, also known as alpha-lipoic acid, may have a role in treating diabetic neuropathy, given that a study was conducted to assess its efficacy in non-insulin dependent diabetic patients with symptomatic diabetic neuropathy. However, it's important to note that this is a specific study with a limited sample size, so it doesn't definitively prove that thioctic acid treats diabetic neuropathy in all cases. It does, however, suggest a potential area for further research." +21616335,Ampicillin treats Infection,1429,"Penicillin Allergy in Pregnancy: Moving From ""Rash"" Decisions to Accurate Diagnosis.The emergence of beta-lactam-resistant pathogenic organisms has resulted in limitation or even elimination of drugs such as penicillin and ampicillin from available antibiotic choices for treating common infections in obstetrics and gynecology.",True,"Is the triple 'Ampicillin treats Infection' supported by the sentence: 'Penicillin Allergy in Pregnancy: Moving From ""Rash"" Decisions to Accurate Diagnosis.The emergence of beta-lactam-resistant pathogenic organisms has resulted in limitation or even elimination of drugs such as penicillin and ampicillin from available antibiotic choices for treating common infections in obstetrics and gynecology.'?","Yes, the statement supports the idea that ampicillin is used to treat certain infections, but it also suggests that due to the emergence of beta-lactam-resistant organisms, its use has been limited or eliminated in some cases, particularly in obstetrics and gynecology." +16205290,Ampicillin treats chorioamnionitis,1430,"The patient was treated with pressors and antibiotics and was admitted to the medical intensive care unit where she received ampicillin, gentamycin, and clindamycin for suspected chorioamnionitis.",True,"Is the triple 'Ampicillin treats chorioamnionitis' supported by the sentence: 'The patient was treated with pressors and antibiotics and was admitted to the medical intensive care unit where she received ampicillin, gentamycin, and clindamycin for suspected chorioamnionitis.'?","Yes, it is indirectly supported because ampicillin is mentioned as being used to treat suspected chorioamnionitis in the provided sentence, which aligns with the statement that ampicillin treats chorioamnionitis." +15830384,Ampicillin treats bacterial infectious disease,1431,Based on these results aztreonam appears to be at least as effective as and possibly more effective than amikacin when used initially with ampicillin for empiric treatment of neonatal bacterial infections.,True,Is the triple 'Ampicillin treats bacterial infectious disease' supported by the sentence: 'Based on these results aztreonam appears to be at least as effective as and possibly more effective than amikacin when used initially with ampicillin for empiric treatment of neonatal bacterial infections.'?,"Yes, it is indirectly supported because it mentions ampicillin being used for empiric treatment of neonatal bacterial infections, which implies that ampicillin is used to treat bacterial infections, as stated in your initial statement." +14976711,Ampicillin treats osteomyelitis,1432,"When antibiotic therapy was delayed for seven days, osteomyelitis developed in four of eight animals treated locally with microencapsulated ampicillin and in six of eight animals that received parenteral ampicillin therapy.",True,"Is the triple 'Ampicillin treats osteomyelitis' supported by the sentence: 'When antibiotic therapy was delayed for seven days, osteomyelitis developed in four of eight animals treated locally with microencapsulated ampicillin and in six of eight animals that received parenteral ampicillin therapy.'?","Yes, it is indirectly supported. The sentence suggests that ampicillin can be used to treat osteomyelitis, as animals treated with ampicillin, either locally or parenterally, had a lower incidence of developing osteomyelitis when treatment was not delayed." +12551965,Ampicillin treats Sepsis,1433,"In the present study, we validated the antagonism in combinations of VCM with other beta-lactams, i.e., flomoxef (FMOX), ampicillin (AMPC), azthreonam (AZT) and imipenem/cilastatin (IPM/CS), in systemic infections and pneumoniain in mice.",True,"Is the triple 'Ampicillin treats Sepsis' supported by the sentence: 'In the present study, we validated the antagonism in combinations of VCM with other beta-lactams, i.e., flomoxef (FMOX), ampicillin (AMPC), azthreonam (AZT) and imipenem/cilastatin (IPM/CS), in systemic infections and pneumoniain in mice.'?","Yes, the statement that ampicillin treats sepsis is not directly supported by this sentence as it does not explicitly mention sepsis being treated with ampicillin. However, it does imply that ampicillin has antibacterial properties in systemic infections when used in combination with other beta-lactams in mice models. So in a roundabout way, it could be interpreted as supporting ampicillin's use in treating certain types of infections in animals, but not specifically sepsis in humans." +9906170,Ampicillin treats bacterial meningitis,1434,"The mortality rate in this type of BM is still high among those treated with ampicillin or penicillin, and a decrease in the mortality rate was not observed when the reported cases in Spain in the last 30 years were analyzed.",False,"Is the triple 'Ampicillin treats bacterial meningitis' supported by the sentence: 'The mortality rate in this type of BM is still high among those treated with ampicillin or penicillin, and a decrease in the mortality rate was not observed when the reported cases in Spain in the last 30 years were analyzed.'?","No, it is not directly or indirectly supported, as it suggests that ampicillin may not be effective in reducing the mortality rate for a certain type of bacterial meningitis (BM)." +8394714,Ampicillin treats gonorrhea,1435,Ampicillin has assumed a prominent role in the treatment of gonorrhoea.,True,Is the triple 'Ampicillin treats gonorrhea' supported by the sentence: 'Ampicillin has assumed a prominent role in the treatment of gonorrhoea.'?,"Yes, it is indirectly supported because both sentences suggest that Ampicillin is used in the treatment of gonorrhoea, although they do not explicitly state that Ampicillin treats gonorrhoea directly." +7166712,Ampicillin treats pneumonia,1436,[Clinical efficacy of sulbactam/ampicillin in comparison with cefotiam in the treatment of elderly patients with pneumonia].,False,Is the triple 'Ampicillin treats pneumonia' supported by the sentence: '[Clinical efficacy of sulbactam/ampicillin in comparison with cefotiam in the treatment of elderly patients with pneumonia].'?,"No, it is not directly supported because the comparison is between Ampicillin/Sulbactam and Cefotiam, not specifically Ampicillin alone for treating pneumonia in elderly patients." +22520021,Carbenicillin treats bacterial infectious disease,1437,In this study results of treatment with ceftazidime were superior to results of treatment with amikacin/carbenicillin for invasive bacterial infections of newborn infants.,True,Is the triple 'Carbenicillin treats bacterial infectious disease' supported by the sentence: 'In this study results of treatment with ceftazidime were superior to results of treatment with amikacin/carbenicillin for invasive bacterial infections of newborn infants.'?,"Yes, it is indirectly supported because it mentions carbenicillin being used to treat invasive bacterial infections in newborn infants, thus implying its use in treating bacterial infections. However, it does not specifically state that carbenicillin treats bacterial infections on its own, but rather in combination with amikacin, and it suggests that ceftazidime may be more effective for such infections in newborn infants, implying that carbenicillin may not be as effective in certain situations." +26119472,Bacampicillin treats bacterial infectious disease,1438,Clinical trial of bacampicillin in acute bacterial infections.,True,Is the triple 'Bacampicillin treats bacterial infectious disease' supported by the sentence: 'Clinical trial of bacampicillin in acute bacterial infections.'?,"Yes, it is indirectly supported because a clinical trial implies that a drug (like Bacampicillin) is being tested for its effectiveness in treating a condition (like acute bacterial infections). However, it doesn't directly confirm that Bacampicillin specifically treats bacterial infections as the sentence doesn't provide explicit information about the outcomes of the clinical trial." +25659721,Aspoxicillin treats bacterial infectious disease,1439,The above results suggest that ASPC is an useful antibiotic for treating pediatric bacterial infections.,True,Is the triple 'Aspoxicillin treats bacterial infectious disease' supported by the sentence: 'The above results suggest that ASPC is an useful antibiotic for treating pediatric bacterial infections.'?,"Yes, it can be inferred as supported, as both statements refer to the antibiotic properties of Aspoxicillin for treating bacterial infections, although they do not explicitly state it in identical terms." +13845936,Mezlocillin treats bacterial infectious disease,1440,"An open, multicentre study was performed in hospital in-patients at a total of 12 German hospitals to investigate the efficacy and tolerability of sulbactam combined with mezlocillin, piperacillin or cefotaxime in severe bacterial infections.",True,"Is the triple 'Mezlocillin treats bacterial infectious disease' supported by the sentence: 'An open, multicentre study was performed in hospital in-patients at a total of 12 German hospitals to investigate the efficacy and tolerability of sulbactam combined with mezlocillin, piperacillin or cefotaxime in severe bacterial infections.'?","Yes, it is indirectly supported because Mezlocillin is mentioned as one of the antibiotics used in combination with sulbactam to treat severe bacterial infections in a multi-center clinical trial." +7407212,Benzoyl Peroxide treats acne,1441,"Treatments for acne can be topical or systemic, and include retinoids, antibiotics, benzoyl peroxide, azelaic acid, and hormonal therapy.",True,"Is the triple 'Benzoyl Peroxide treats acne' supported by the sentence: 'Treatments for acne can be topical or systemic, and include retinoids, antibiotics, benzoyl peroxide, azelaic acid, and hormonal therapy.'?","Yes, the statement ""Benzoyl Peroxide treats acne"" is directly supported by the provided sentence as it is listed as a treatment for acne." +26328908,Proglumide treats peptic ulcer disease,1442,[Controlled and double-blind study of the treatment of peptic ulcer with cimetidine and proglumide].,True,Is the triple 'Proglumide treats peptic ulcer disease' supported by the sentence: '[Controlled and double-blind study of the treatment of peptic ulcer with cimetidine and proglumide].'?,"Yes, it is indirectly supported, as the mention of a controlled and double-blind study involving proglumide for treating peptic ulcers suggests that proglumide may have some efficacy in treating this condition, even though it does not directly state that proglumide treats peptic ulcers on its own." +13022426,Pirenzepine treats gastroesophageal reflux disease,1443,Pirenzepine may provide a unique alternative for some GERD patients who may be refractory to other therapies of GERD.,True,Is the triple 'Pirenzepine treats gastroesophageal reflux disease' supported by the sentence: 'Pirenzepine may provide a unique alternative for some GERD patients who may be refractory to other therapies of GERD.'?,"Yes, it is indirectly supported because it suggests that Pirenzepine can be an alternative treatment for some patients with GERD, which implies that it can treat GERD, even if it's not a primary treatment for all patients." +10839963,Pirenzepine treats peptic ulcer disease,1444,Four hundred and two patients with peptic ulcer were selected for acute therapy with either pirenzepine (100 mg/day) or cimetidine (800 mg/day) using the envelope method.,True,Is the triple 'Pirenzepine treats peptic ulcer disease' supported by the sentence: 'Four hundred and two patients with peptic ulcer were selected for acute therapy with either pirenzepine (100 mg/day) or cimetidine (800 mg/day) using the envelope method.'?,"Yes, it is indirectly supported because it mentions that pirenzepine was used in a study on peptic ulcer, but it does not explicitly state that pirenzepine treats peptic ulcer disease." +16332442,Magnesium Oxide treats autosomal recessive inherited pseudoxanthoma elasticum,1445,"In that context, magnesium oxide significantly reduced CIMT in PXE mice, and may be useful for disease prevention in PXE patients.",True,"Is the triple 'Magnesium Oxide treats autosomal recessive inherited pseudoxanthoma elasticum' supported by the sentence: 'In that context, magnesium oxide significantly reduced CIMT in PXE mice, and may be useful for disease prevention in PXE patients.'?","Yes, it is indirectly supported because Magnesium oxide was shown to significantly reduce CIMT in PXE mice, implying potential benefits for PXE patients, although it does not directly mention its effects on autosomal recessive inherited pseudoxanthoma elasticum (PXE)." +15225864,Magnesium Oxide treats constipation disorder,1446,"This report presents the rare case of a 75-year-old woman who developed a rectal obstruction caused by a pharmacobezoar, following the long-term ingestion of magnesium oxide cathartics for constipation.",True,"Is the triple 'Magnesium Oxide treats constipation disorder' supported by the sentence: 'This report presents the rare case of a 75-year-old woman who developed a rectal obstruction caused by a pharmacobezoar, following the long-term ingestion of magnesium oxide cathartics for constipation.'?","Yes, it is. The presence of a pharmacobezoar (a mass formed from undigested medication) in the rectum due to long-term ingestion of magnesium oxide cathartics for constipation suggests that magnesium oxide can have an effect on bowel movements, thus providing indirect support for its use in treating constipation disorders." +26045826,Ticarcillin treats Sepsis,1447,Mezlocillin and ticarcillin in the treatment of patients with serious systemic infections.,True,Is the triple 'Ticarcillin treats Sepsis' supported by the sentence: 'Mezlocillin and ticarcillin in the treatment of patients with serious systemic infections.'?,"Yes, it is indirectly supported. The provided sentence mentions that Ticarcillin is used in the treatment of serious systemic infections, which could include Sepsis, as it is a severe systemic infection. However, it does not explicitly state that Ticarcillin treats Sepsis." +9410149,Ticarcillin treats osteomyelitis,1448,Obviously unbalanced comparative studies showed some benefit of ticarcillin for bone infections caused by Pseudomonas species.,True,Is the triple 'Ticarcillin treats osteomyelitis' supported by the sentence: 'Obviously unbalanced comparative studies showed some benefit of ticarcillin for bone infections caused by Pseudomonas species.'?,"Yes, it is indirectly supported. The given statement suggests that ticarcillin has shown some benefit in treating bone infections caused by Pseudomonas species, which is a type of bacterial infection that can lead to a condition like osteomyelitis. However, it's important to note that this is an indirect inference, as the original statement does not explicitly mention osteomyelitis." +26823243,Urea treats citrullinemia,1449,"The precursors of urea (ammonia, glutamate, glutamine and alpha-amino nitrogen) did not increase after the benzoate administration in the 6 normal subjects as well as in the 2 patients with citrullinaemia.",False,"Is the triple 'Urea treats citrullinemia' supported by the sentence: 'The precursors of urea (ammonia, glutamate, glutamine and alpha-amino nitrogen) did not increase after the benzoate administration in the 6 normal subjects as well as in the 2 patients with citrullinaemia.'?","No, it is not directly supported because it does not mention that urea specifically treats citrullinemia, nor does it provide evidence for its effectiveness in treating this condition. It only states that certain precursors did not increase after benzoate administration in both normal subjects and those with citrullinemia, which does not necessarily imply a treatment relationship with urea for this condition." +25855602,Urea treats argininosuccinic aciduria,1450,The relationship between the formation of urea and argininosuccinate in a patient with argininosuccinic aciduria studied with labelled precursors.,True,Is the triple 'Urea treats argininosuccinic aciduria' supported by the sentence: 'The relationship between the formation of urea and argininosuccinate in a patient with argininosuccinic aciduria studied with labelled precursors.'?,"Yes, it is indirectly supported, as both sentences discuss a connection between urea and argininosuccinate in the context of argininosuccinic aciduria, implying that urea may have a role in treating this condition, even if not explicitly stated in the second sentence." +19420190,Urea treats psoriasis,1451,"In the treatment of psoriasis with urea and urea-combined preparations, the individual sequence should be so clearly prescribed such that acceptance is assured.",True,"Is the triple 'Urea treats psoriasis' supported by the sentence: 'In the treatment of psoriasis with urea and urea-combined preparations, the individual sequence should be so clearly prescribed such that acceptance is assured.'?","Yes, it is indirectly supported because it mentions that there is a treatment for psoriasis using urea, which implies that it has some positive effect on it, even though it does not explicitly state that it treats it directly." +17323203,Urea treats radiodermatitis,1452,"RESULTS: Effective treatment with urea has been reported for the following conditions: ichthyosis, xerosis, atopic dermatitis/eczema, contact dermatitis, radiation induced dermatitis, psoriasis/seborrheic dermatitis, onychomycosis, tinea pedis, keratosis, pruritus, and dystrophic nails.",True,"Is the triple 'Urea treats radiodermatitis' supported by the sentence: 'RESULTS: Effective treatment with urea has been reported for the following conditions: ichthyosis, xerosis, atopic dermatitis/eczema, contact dermatitis, radiation induced dermatitis, psoriasis/seborrheic dermatitis, onychomycosis, tinea pedis, keratosis, pruritus, and dystrophic nails.'?","Yes, it is indirectly supported, as radiation induced dermatitis is one of the conditions listed that urea is effective in treating, according to the given study results." +15413374,Urea treats hepatocellular carcinoma,1453,"INTRODUCTION: Sorafenib is a novel oral bis-aryl urea compound that has proven survival benefit in patients with advanced hepatocellular carcinoma (HCC), for which several therapies are currently available with unsatisfactory results.",False,"Is the triple 'Urea treats hepatocellular carcinoma' supported by the sentence: 'INTRODUCTION: Sorafenib is a novel oral bis-aryl urea compound that has proven survival benefit in patients with advanced hepatocellular carcinoma (HCC), for which several therapies are currently available with unsatisfactory results.'?","No, it is not directly nor indirectly supported, as it mentions sorafenib, a bis-aryl urea compound, not urea itself, as a treatment for HCC, with unsatisfactory results for other treatments being mentioned, not urea treatments specifically." +12068406,Urea treats type 2 diabetes mellitus,1454,These findings are consistent with the inhibition of hepatic glycogenolysis and support the use of acyl ureas for the treatment of type 2 diabetes.,True,Is the triple 'Urea treats type 2 diabetes mellitus' supported by the sentence: 'These findings are consistent with the inhibition of hepatic glycogenolysis and support the use of acyl ureas for the treatment of type 2 diabetes.'?,"Yes, it is indirectly supported. The statement mentions the use of acyl ureas for treating type 2 diabetes, which is a class of drugs that includes ureas. Ureas have been found to inhibit hepatic glycogenolysis, a process that can help manage type 2 diabetes. Therefore, it can be inferred that ureas, like urea, could potentially be used for treating type 2 diabetes, although urea itself is not typically used as a treatment for this condition in clinical practice." +11649881,Urea treats Pain,1455,"Novel transient receptor potential vanilloid 1 receptor antagonists for the treatment of pain: structure-activity relationships for ureas with quinoline, isoquinoline, quinazoline, phthalazine, quinoxaline, and cinnoline moieties.",True,"Is the triple 'Urea treats Pain' supported by the sentence: 'Novel transient receptor potential vanilloid 1 receptor antagonists for the treatment of pain: structure-activity relationships for ureas with quinoline, isoquinoline, quinazoline, phthalazine, quinoxaline, and cinnoline moieties.'?","Yes, it is indirectly supported because the article mentions that ureas have been studied as Transient Receptor Potential Vanilloid type-1 (TRPV1) receptor antagonists, which play a role in pain management, but it does not directly mention that urea specifically is used to treat pain, nor does it mention Urea treating pain in humans, it is based on studies in vitro and in animals, so it would be an assumption to say that Urea can treat pain in humans, it would require further studies to confirm this hypothesis, in addition, pain is a complex process that involves more mechanisms than just TRPV1, so it would be an oversimplification to say that a single molecule can treat pain, it would require a combination of different molecules acting on different targets to effectively treat pain, in addition, it would also depend on the type of pain, location, severity, duration, among other factors, so it is important to consult with a healthcare professional before taking any medication for pain management, they will be able to provide a proper diagnosis, treatment, and follow-up, as well as monitor possible side effects, drug interactions, among other factors, it is also important to note that pain" +10679439,Urea treats skin disorder,1456,[TROPHIC ACTION OF UREA AND ITS USE IN THE TREATMENT OF NEUROTROPHIC SKIN DISEASES].,True,Is the triple 'Urea treats skin disorder' supported by the sentence: '[TROPHIC ACTION OF UREA AND ITS USE IN THE TREATMENT OF NEUROTROPHIC SKIN DISEASES].'?,"Yes, it is indirectly supported. The title of the article mentions the trophic action of urea, which refers to its nourishing effect on cells, and its use in treating neurotrophic skin diseases, a type of skin disorder. However, it does not explicitly state that urea treats all types of skin disorders, but it does support its use in certain ones." +10511987,Urea treats diabetes mellitus,1457,"[Preliminary note on the oral treatment of diabetes by N-sulfonyl-p-methylbenzene-N'-n-butyl urea or D 860, a product free of antibacterial action].",False,"Is the triple 'Urea treats diabetes mellitus' supported by the sentence: '[Preliminary note on the oral treatment of diabetes by N-sulfonyl-p-methylbenzene-N'-n-butyl urea or D 860, a product free of antibacterial action].'?","No, it is not directly supported because urea is not mentioned in this statement, but it could be implied if D 860 is a form of urea, which is not specified in this statement." +8678587,"Urea treats dermatitis, atopic",1458,"In the present report, we compared two creams, identical with the exception that one contained both urea and sodium chloride and the other urea alone, in 22 patients with atopic dermatitis.",True,"Is the triple 'Urea treats dermatitis, atopic' supported by the sentence: 'In the present report, we compared two creams, identical with the exception that one contained both urea and sodium chloride and the other urea alone, in 22 patients with atopic dermatitis.'?","Yes, it is indirectly supported because both urea and sodium chloride were tested on patients with atopic dermatitis, implying that urea might have a role in treating this condition. However, it does not directly state that urea alone can treat atopic dermatitis, as one of the creams contained both urea and sodium chloride." +27251301,Mannitol treats brain cancer,1459,"Hyperosmolar blood-brain barrier disruption (HBBBD), produced by infusion of mannitol into the cerebral arteries, has been used in the treatment of brain tumors to increase drug delivery to tumor and adjacent brain.",True,"Is the triple 'Mannitol treats brain cancer' supported by the sentence: 'Hyperosmolar blood-brain barrier disruption (HBBBD), produced by infusion of mannitol into the cerebral arteries, has been used in the treatment of brain tumors to increase drug delivery to tumor and adjacent brain.'?","Yes, it is indirectly supported. The passage mentions that mannitol can be used to disrupt the blood-brain barrier, which can increase drug delivery to brain tumors. This suggests that mannitol could potentially play a role in treating brain cancer, even though it doesn't explicitly say that mannitol treats brain cancer itself." +21059003,Mannitol treats hearing loss disorder,1460,[Effects of mannitol on the fluids of the internal ear. Use in the treatment of deafness].,True,Is the triple 'Mannitol treats hearing loss disorder' supported by the sentence: '[Effects of mannitol on the fluids of the internal ear. Use in the treatment of deafness].'?,"Yes, it is indirectly supported as it mentions the use of Mannitol in treating deafness, which implies it has some positive effect on hearing loss disorders, although it does not explicitly state that Mannitol treats hearing loss disorders." +20425957,Mannitol treats osteoarthritis,1461,Objective: To assess efficacy and safety of a single intra-articular injection of 2% sodium hyaluronate plus 0.5% mannitol in patients with symptomatic osteoarthritis of the knee.,True,Is the triple 'Mannitol treats osteoarthritis' supported by the sentence: 'Objective: To assess efficacy and safety of a single intra-articular injection of 2% sodium hyaluronate plus 0.5% mannitol in patients with symptomatic osteoarthritis of the knee.'?,"Yes, it is indirectly supported because it mentions both mannitol and symptomatic osteoarthritis of the knee in a study about an intra-articular injection of a solution containing both substances, implying a potential therapeutic effect of mannitol in treating this condition, even though it's not explicitly stated in this context that mannitol alone treats osteoarthritis." +16945033,Mannitol treats hypotensive disorder,1462,"These values were correlated with expected risk factors for lactatemia including length of surgery, Body Mass Index (BMI), hypotension, hemoglobin and mannitol therapy.",True,"Is the triple 'Mannitol treats hypotensive disorder' supported by the sentence: 'These values were correlated with expected risk factors for lactatemia including length of surgery, Body Mass Index (BMI), hypotension, hemoglobin and mannitol therapy.'?","Yes, it is indirectly supported because mannitol therapy is mentioned as a factor associated with a condition (lactatemia) that can be influenced by hypotension, which suggests that mannitol may have a role in managing hypotension. However, it doesn't directly state that mannitol treats hypotensive disorder." +12644644,Mannitol treats Pain,1463,"Further treatments with intravenous mannitol, oral carbonic anhydrase inhibitor, topical antiglaumatic agents and subconjunctival 5-fluorouracil (5-FU) injections all failed to control relapsing pain and IOP elevation.",False,"Is the triple 'Mannitol treats Pain' supported by the sentence: 'Further treatments with intravenous mannitol, oral carbonic anhydrase inhibitor, topical antiglaumatic agents and subconjunctival 5-fluorouracil (5-FU) injections all failed to control relapsing pain and IOP elevation.'?","No. In fact, it suggests the opposite as all those treatments mentioned failed to control pain and IOP elevation, implying that Mannitol did not treat pain in this case either." +11774217,Mannitol treats brain injury,1464,CONCLUSIONS: The results suggested that mannitol could improve cerebral perfusion in patients with mild brain damage.,True,Is the triple 'Mannitol treats brain injury' supported by the sentence: 'CONCLUSIONS: The results suggested that mannitol could improve cerebral perfusion in patients with mild brain damage.'?,"Yes, it is indirectly supported. The conclusion suggests that mannitol can improve cerebral perfusion in patients with mild brain damage, which implies a potential positive effect on brain injury." +11660589,Mannitol treats malaria,1465,"A possibly indulgent wish list of outcome (mortality) studies using currently known treatment modalities, however, includes the loading dose of quinine, vigorous fluid replacement, ET, the artemisinins, mannitol, and N-acetylcysteine in the treatment of severe malaria.",True,"Is the triple 'Mannitol treats malaria' supported by the sentence: 'A possibly indulgent wish list of outcome (mortality) studies using currently known treatment modalities, however, includes the loading dose of quinine, vigorous fluid replacement, ET, the artemisinins, mannitol, and N-acetylcysteine in the treatment of severe malaria.'?","Yes, the statement you provided does suggest that mannitol is used in the treatment of severe malaria, thus providing indirect support to the claim that mannitol treats malaria. However, it's important to note that mannitol is not typically a first-line treatment for malaria, but rather used in severe cases to manage complications such as cerebral malaria, which can cause swelling in the brain." +11613595,Mannitol treats chronic obstructive pulmonary disease,1466,CONCLUSION: We propose that AHR to mannitol could predict ICS-responsiveness in mild to moderately severe COPD patients.,True,Is the triple 'Mannitol treats chronic obstructive pulmonary disease' supported by the sentence: 'CONCLUSION: We propose that AHR to mannitol could predict ICS-responsiveness in mild to moderately severe COPD patients.'?,"Yes, it is indirectly supported because it suggests a relationship between mannitol and COPD patient response to inhaled corticosteroids (ICS), implying potential therapeutic use in managing COPD symptoms, which aligns with the statement about mannitol treating COPD. However, it's important to note this is an interpretation based on a single sentence, and further research is needed for a more definitive conclusion." +10724016,Mannitol treats acute kidney failure,1467,MANNITOL THERAPY IN ACUTE RENAL FAILURE.,True,Is the triple 'Mannitol treats acute kidney failure' supported by the sentence: 'MANNITOL THERAPY IN ACUTE RENAL FAILURE.'?,"Yes, the statement ""Mannitol treats acute kidney failure"" is indirectly supported by the title ""MANNITOL THERAPY IN ACUTE RENAL FAILURE."" The title suggests that mannitol is being used as a therapy for acute renal (kidney) failure, implying a potential treating effect. However, it's important to note that this is an interpretation based on a title alone, and more comprehensive information, such as a full research article, would be needed for a more definitive conclusion." +10707564,Mannitol treats injury,1468,Mannitol has a beneficial effect on ischemic injury following a short-duration forebrain ischemic insult in rats.,True,Is the triple 'Mannitol treats injury' supported by the sentence: 'Mannitol has a beneficial effect on ischemic injury following a short-duration forebrain ischemic insult in rats.'?,"Yes, the statement ""Mannitol has a beneficial effect on ischemic injury following a short-duration forebrain ischemic insult in rats."" does provide some level of indirect support to the claim that ""Mannitol treats injury"". This is because ischemia is a type of injury characterized by insufficient blood supply to an organ or part of the body, often resulting in tissue damage. Therefore, if mannitol has a positive effect on ischemic injury, it can be inferred that it may help in treating certain types of injuries, although it's important to note that this doesn't necessarily mean it's effective for all types of injuries." +9454905,Mannitol treats ciguatera fish poisoning,1469,IV mannitol is considered the treatment of choice for CP but has not been evaluated in a double-blind randomized trial.,True,Is the triple 'Mannitol treats ciguatera fish poisoning' supported by the sentence: 'IV mannitol is considered the treatment of choice for CP but has not been evaluated in a double-blind randomized trial.'?,"Yes, it is indirectly supported because both statements discuss Mannitol as a potential treatment for Ciguatera Fish Poisoning (CP), even though one statement mentions a lack of evaluation in a specific type of clinical trial." +9438138,Mannitol treats stroke disorder,1470,Effects of intravenous mannitol on EEG recordings in stroke patients.,False,Is the triple 'Mannitol treats stroke disorder' supported by the sentence: 'Effects of intravenous mannitol on EEG recordings in stroke patients.'?,"No, it is not directly supported, as this statement discusses the effects of mannitol on EEG recordings in stroke patients, not its impact on treating stroke disorders specifically." +8850005,Mannitol treats coronary artery disorder,1471,"The data suggest the need to further evaluate the physiological importance of the increase in coronary blood flow produced by mannitol in patients with coronary artery disease and indicate the possibility that mannitol might be of value in treating certain problems in patients with coronary artery disease,",True,"Is the triple 'Mannitol treats coronary artery disorder' supported by the sentence: 'The data suggest the need to further evaluate the physiological importance of the increase in coronary blood flow produced by mannitol in patients with coronary artery disease and indicate the possibility that mannitol might be of value in treating certain problems in patients with coronary artery disease,'?","Yes, it is indirectly supported. The given sentence suggests that mannitol increases coronary blood flow in patients with coronary artery disease, which implies that it might have a positive effect on certain problems related to this disease. However, it does not explicitly state that mannitol treats coronary artery disorders, but rather implies it might be useful in treatment." +8674974,Mannitol treats bronchiectasis,1472,The 24-h effect of mannitol on the clearance of mucus in patients with bronchiectasis.,True,Is the triple 'Mannitol treats bronchiectasis' supported by the sentence: 'The 24-h effect of mannitol on the clearance of mucus in patients with bronchiectasis.'?,"Yes, it is indirectly supported, as both sentences discuss a relationship between Mannitol and Bronchiectasis, with a focus on mucus clearance in patients with Bronchiectasis in the second sentence, which aligns with the treatment aspect in the first sentence." +8007841,"Mannitol treats chronic myelogenous leukemia, BCR-ABL1 positive",1473,Treatment of chronic myelocytic leukaemia with dibromo-mannitol (myelobromol).,False,"Is the triple 'Mannitol treats chronic myelogenous leukemia, BCR-ABL1 positive' supported by the sentence: 'Treatment of chronic myelocytic leukaemia with dibromo-mannitol (myelobromol).'?","No, because dibromo-mannitol (myelobromol) is not the same as Mannitol, even though they both contain mannose. The statement would be more likely to be true if it mentioned mannose instead of Mannitol specifically." +7780960,Mannitol treats cystic fibrosis,1474,Inhaled mannitol is a potential mucoactive agent in cystic fibrosis patients.,True,Is the triple 'Mannitol treats cystic fibrosis' supported by the sentence: 'Inhaled mannitol is a potential mucoactive agent in cystic fibrosis patients.'?,"Yes, it is indirectly supported. The statement suggests that inhaled Mannitol could potentially be used to treat symptoms of Cystic Fibrosis, which aligns with the claim that Mannitol can be used to treat Cystic Fibrosis, although it doesn't directly confirm that Mannitol is used to treat Cystic Fibrosis." +7352141,Mannitol treats intracranial hypertension,1475,"CONCLUSION: Hypertonic saline, in both 3 and 23.4% concentrations, is as effective as mannitol in the treatment of intracranial hypertension observed in association with ICH.",True,"Is the triple 'Mannitol treats intracranial hypertension' supported by the sentence: 'CONCLUSION: Hypertonic saline, in both 3 and 23.4% concentrations, is as effective as mannitol in the treatment of intracranial hypertension observed in association with ICH.'?","Yes, it is indirectly supported because it suggests that mannitol is effective in treating intracranial hypertension, which aligns with the statement that mannitol treats intracranial hypertension, even though it doesn't directly mention Mannitol's effectiveness compared to hypertonic saline." +7084538,Mannitol treats brain edema,1476,CONCLUSIONS: Acute mannitol used in patients with cerebral edema after a large hemispheric infarction does not alter midline tissue shifts or worsen neurologic status.,False,Is the triple 'Mannitol treats brain edema' supported by the sentence: 'CONCLUSIONS: Acute mannitol used in patients with cerebral edema after a large hemispheric infarction does not alter midline tissue shifts or worsen neurologic status.'?,"No, it is not directly or indirectly supported because the conclusion states that acute use of mannitol does not alter midline tissue shifts or worsen neurologic status, which does not imply that it treats brain edema but rather suggests its lack of effectiveness for this specific use case after a large hemispheric infarction." +23769437,Temocillin treats bacterial infectious disease with sepsis,1477,The objective is to investigate if temocillin is non-inferior to carbapenems in the targeted treatment of bacteraemia due to 3GCR-E.,True,Is the triple 'Temocillin treats bacterial infectious disease with sepsis' supported by the sentence: 'The objective is to investigate if temocillin is non-inferior to carbapenems in the targeted treatment of bacteraemia due to 3GCR-E.'?,"Yes, it is indirectly supported. The statement suggests that temocillin is being investigated for its effectiveness in treating bacteraemia due to 3GCR-E, which can be a type of bacterial infection causing sepsis, a life-threatening condition." +17734631,Artesunic acid treats hepatocellular carcinoma,1478,CONCLUSION: These findings indicate that artesunate could offer a new approach to the therapy of hepatocellular carcinoma.,True,Is the triple 'Artesunic acid treats hepatocellular carcinoma' supported by the sentence: 'CONCLUSION: These findings indicate that artesunate could offer a new approach to the therapy of hepatocellular carcinoma.'?,"Yes, it is indirectly supported, as the conclusion suggests that artesunate may be beneficial for treating hepatocellular carcinoma, which aligns with the statement about Artesunic acid treating it, given that Artesunate is a derivative of Artesunic acid." +16415826,Artesunic acid treats Crohn disease,1479,Our data suggest a novel clinical application of artesunate as a potential therapy for Crohn's disease.,True,Is the triple 'Artesunic acid treats Crohn disease' supported by the sentence: 'Our data suggest a novel clinical application of artesunate as a potential therapy for Crohn's disease.'?,"Yes, it is indirectly supported. The provided sentence suggests that there is potential for using Artesunate as a therapy for Crohn's disease, which aligns with the claim that Artesunic acid could be used to treat Crohn's disease. However, it's important to note that this is an inference, not a direct statement, hence it's indirect support." +15681287,Artesunic acid treats breast neoplasm,1480,Taken together our in vitro and in vivo results correlate well showing for the first time that artesunate induces resistance in highly metastatic breast tumors.,False,Is the triple 'Artesunic acid treats breast neoplasm' supported by the sentence: 'Taken together our in vitro and in vivo results correlate well showing for the first time that artesunate induces resistance in highly metastatic breast tumors.'?,"No, it does not support that statement directly or indirectly, as it states that artesunate induces resistance to treatment, not that it is an effective treatment for breast cancer." +13704055,Artesunic acid treats cytomegalovirus infection,1481,"This is the first report of treatment of cytomegalovirus infection with artesunate, for a stem cell transplant recipient with a newly identified foscarnet-resistant and ganciclovir-resistant DNA polymerase L776M mutation.",True,"Is the triple 'Artesunic acid treats cytomegalovirus infection' supported by the sentence: 'This is the first report of treatment of cytomegalovirus infection with artesunate, for a stem cell transplant recipient with a newly identified foscarnet-resistant and ganciclovir-resistant DNA polymerase L776M mutation.'?","Yes, it does provide some support, although indirect, as it mentions artesunate being used to treat a case of cytomegalovirus (CMV) infection in a patient with foscarnet-resistant and ganciclovir-resistant DNA polymerase L776M mutation, which implies that artesunate could potentially be an alternative treatment for CMV infections that are resistant to other forms of therapy." +13022850,Artesunic acid treats neoplasm,1482,The anticancer activity of artesunate has also been shown in human xenograft tumors in mice.,True,Is the triple 'Artesunic acid treats neoplasm' supported by the sentence: 'The anticancer activity of artesunate has also been shown in human xenograft tumors in mice.'?,"Yes, it is indirectly supported. The statement about anticancer activity in human xenograft tumors in mice suggests that artesunate may have potential in treating neoplasms, which is a type of abnormal tissue growth commonly referred to as tumors or cancers. However, it's important to note that this is an indirect inference, as the original statement does not explicitly mention 'neoplasms'." +10539481,Artesunic acid treats Fever,1483,The 2 groups that received artesunate experienced considerably more rapid reduction in parasitemia and in fever than the group that received only mefloquine (p.002).,True,Is the triple 'Artesunic acid treats Fever' supported by the sentence: 'The 2 groups that received artesunate experienced considerably more rapid reduction in parasitemia and in fever than the group that received only mefloquine (p.002).'?,"Yes, it can be interpreted as indirect support, as faster reduction in fever is mentioned in the provided statement, which implies a potential treatment effect of Artesunic acid on fever, although it is not explicitly stated as a fever treatment in this particular statement." +10009785,Artesunic acid treats schistosomiasis,1484,CONCLUSION: A mass chemotherapy in conjunction with health education and oral artesunate for preventing reinfection in transmission season is effective for the control of schistosomiasis in lake regions.,True,Is the triple 'Artesunic acid treats schistosomiasis' supported by the sentence: 'CONCLUSION: A mass chemotherapy in conjunction with health education and oral artesunate for preventing reinfection in transmission season is effective for the control of schistosomiasis in lake regions.'?,"Yes, it is indirectly supported because it mentions oral artesunate as effective for controlling schistosomiasis, which implies that artesunic acid (a derivative of artesunate) could also be effective, especially when used in a mass treatment setting as mentioned in your provided sentence." +9194607,Artesunic acid treats urinary schistosomiasis,1485,"Artesunate and praziquantel for the treatment of Schistosoma haematobium infections: a double-blind, randomized, placebo-controlled study.",True,"Is the triple 'Artesunic acid treats urinary schistosomiasis' supported by the sentence: 'Artesunate and praziquantel for the treatment of Schistosoma haematobium infections: a double-blind, randomized, placebo-controlled study.'?","Yes, it is indirectly supported because both Artesunate (a derivative of Artesunic Acid) and Praziquantel were used together in a study to treat Schistosoma haematobium infections, which is a type of urinary schistosomiasis. However, it's important to note that Artesunic Acid itself was not used in this study, but its derivative was." +7990355,Artesunic acid treats Plasmodium vivax malaria,1486,"To define the current efficacy of Fansidar (F. Hoffmann-La Roche Ltd., Basel Switzerland) (pyrimethamine and sulfadoxine), primaquine in a high dose, and artesunate for treating acute Plasmodium vivax malaria, we conducted a comparative clinical trial of these 3 drugs in an open-label study.",True,"Is the triple 'Artesunic acid treats Plasmodium vivax malaria' supported by the sentence: 'To define the current efficacy of Fansidar (F. Hoffmann-La Roche Ltd., Basel Switzerland) (pyrimethamine and sulfadoxine), primaquine in a high dose, and artesunate for treating acute Plasmodium vivax malaria, we conducted a comparative clinical trial of these 3 drugs in an open-label study.'?","Yes, the statement does support it indirectly, as it mentions a comparative clinical trial of three drugs including artesunate, which is used in treating acute Plasmodium vivax malaria, thus providing evidence for its use in this context. However, it does not explicitly mention Artesunic acid, which is a different compound, but they both belong to the same class of drugs (Artemisinin derivatives)." +7595063,Artesunic acid treats malaria,1487,Artemether and artesunate have also been administered by the rectal route with highly promising results for treatment of severe malaria.,True,Is the triple 'Artesunic acid treats malaria' supported by the sentence: 'Artemether and artesunate have also been administered by the rectal route with highly promising results for treatment of severe malaria.'?,"Yes, it is indirectly supported because both Artemether and Artesunate, which have shown promising results in treating severe malaria when administered rectally, are derivatives of Artesunic Acid, suggesting a common mechanism of action against malaria." +7113713,Artesunic acid treats Plasmodium falciparum malaria,1488,Declining concentrations of dihydroartemisinin in plasma during 5-day oral treatment with artesunate for Falciparum malaria.,False,Is the triple 'Artesunic acid treats Plasmodium falciparum malaria' supported by the sentence: 'Declining concentrations of dihydroartemisinin in plasma during 5-day oral treatment with artesunate for Falciparum malaria.'?,"No, it is not directly supported because it does not mention that artesunic acid is effective against Plasmodium falciparum malaria, but it does suggest that artesunate, which is related to artesunic acid, is being used to treat Falciparum malaria, which may imply some level of efficacy." +7264251,Artemether treats malaria,1489,These data demonstrate the equality of artemether and quinine for severe malaria and indicate a trend toward greater effectiveness of artemether in regions where there is recognized quinine resistance.,True,Is the triple 'Artemether treats malaria' supported by the sentence: 'These data demonstrate the equality of artemether and quinine for severe malaria and indicate a trend toward greater effectiveness of artemether in regions where there is recognized quinine resistance.'?,"Yes, it is indirectly supported because it suggests that Artemether is as effective as Quinine in treating severe Malaria, with a potential trend towards greater effectiveness in areas where Quinine resistance is recognized." +7168046,Artemether treats Plasmodium falciparum malaria,1490,"The spectrum of falciparum malaria treatment has recently broadened to include new drugs such as artemisinin, artemether or atovaquone/proguanil, the latter being as yet unauthorized in France.",True,"Is the triple 'Artemether treats Plasmodium falciparum malaria' supported by the sentence: 'The spectrum of falciparum malaria treatment has recently broadened to include new drugs such as artemisinin, artemether or atovaquone/proguanil, the latter being as yet unauthorized in France.'?","Yes, it is indirectly supported because it mentions Artemisinin, which Artemether is derived from, as a new drug used in treating Falciparum Malaria, as per the given sentence." +25827221,Isoproterenol treats obstructive lung disease,1491,Investigation into isoprenaline resistance in patients with obstructive lung disease.,True,Is the triple 'Isoproterenol treats obstructive lung disease' supported by the sentence: 'Investigation into isoprenaline resistance in patients with obstructive lung disease.'?,"Yes, it can be inferred as indirect support, since investigating resistance to Isoproterenol (also known as Isoprenaline) in patients with obstructive lung disease suggests that Isoproterenol is used to treat this condition, even if it's about understanding resistance to it." +15441635,Isoproterenol treats lipoma,1492,AIM: The aim of this study was to evaluate the efficacy of isoproterenol and prednisolone in the treatment of subcutaneous lipomas.,False,Is the triple 'Isoproterenol treats lipoma' supported by the sentence: 'AIM: The aim of this study was to evaluate the efficacy of isoproterenol and prednisolone in the treatment of subcutaneous lipomas.'?,"No, it is not directly nor indirectly supported, as there is no mention about prednisolone treating lipomas in the given statement, it's about isoproterenol and prednisolone together in treatment, not isoproterenol alone for treating lipomas." +13881275,Isoproterenol treats orthostatic hypotension,1493,"Microdialysate concentrations of the main neuronal metabolite of norepinephrine (NE) and dihydroxyphenylglycol (DHPG) were measured in skeletal muscle, and plasma concentrations of NE and DHPG were measured in response to i.v. tyramine, yohimbine, and isoproterenol, in patients with PD+NOH, patients with pure autonomic failure (PAF), which is characterized by generalized catecholaminergic denervation, and control subjects.",True,"Is the triple 'Isoproterenol treats orthostatic hypotension' supported by the sentence: 'Microdialysate concentrations of the main neuronal metabolite of norepinephrine (NE) and dihydroxyphenylglycol (DHPG) were measured in skeletal muscle, and plasma concentrations of NE and DHPG were measured in response to i.v. tyramine, yohimbine, and isoproterenol, in patients with PD+NOH, patients with pure autonomic failure (PAF), which is characterized by generalized catecholaminergic denervation, and control subjects.'?","Yes, it is indirectly supported. The sentence mentions that plasma concentrations of NE (norepinephrine) and DHPG were measured in response to isoproterenol in patients with PD+NOH (Parkinson's disease with neurogenic orthostatic hypotension). This suggests that isoproterenol has an effect on NE and DHPG in these patients, which could potentially be beneficial for treating orthostatic hypotension. However, it does not directly state that isoproterenol treats orthostatic hypotension." +11481186,Isoproterenol treats atrial fibrillation,1494,"RESULTS: LAP series analysis shows a reduction of both LP and R index during isoproterenol infusion in SR and AF (RSR = 0.75 +/- 0.07 RSRISO = 0.69 +/- 0.10, p < 0.0001; RAF = 0.31 +/- 0.08 RAFISO = 0.26 +/- 0.09, p < 0.0001; LPSR = 99.99 +/- 0.001 LPSRISO = 99.97 +/- 0.03, p < 0.0001; LPAF = 69.46 +/- 21.55 LPAFISO = 55 +/- 24.75; p < 0.0001).",True,"Is the triple 'Isoproterenol treats atrial fibrillation' supported by the sentence: 'RESULTS: LAP series analysis shows a reduction of both LP and R index during isoproterenol infusion in SR and AF (RSR = 0.75 +/- 0.07 RSRISO = 0.69 +/- 0.10, p < 0.0001; RAF = 0.31 +/- 0.08 RAFISO = 0.26 +/- 0.09, p < 0.0001; LPSR = 99.99 +/- 0.001 LPSRISO = 99.97 +/- 0.03, p < 0.0001; LPAF = 69.46 +/- 21.55 LPAFISO = 55 +/- 24.75; p < 0.0001).'?","Yes, the statement is indirectly supported because it shows that isoproterenol infusion reduces both long period (LP) and short period (R) index during sinus rhythm (SR) and atrial fibrillation (AF). This suggests that isoproterenol may have a role in treating AF, although it does not directly state that it is used for treatment." +9565866,Isoproterenol treats obesity disorder,1495,Decreased responsiveness to isoproterenol in obesity may be due to defects downstream of adenylyl cyclase activation of cyclic AMP.,False,Is the triple 'Isoproterenol treats obesity disorder' supported by the sentence: 'Decreased responsiveness to isoproterenol in obesity may be due to defects downstream of adenylyl cyclase activation of cyclic AMP.'?,"No, it does not support it directly because it suggests a decreased response, not a treatment effect of Isoproterenol on obesity." +8710440,Isoproterenol treats postural orthostatic tachycardia syndrome,1496,the responses of heart rate and the plasma cyclic AMP (cAMP) level to isoproterenol infusion in the supine position were evaluated in 10 POTS patients and 10 age-matched controls.,True,Is the triple 'Isoproterenol treats postural orthostatic tachycardia syndrome' supported by the sentence: 'the responses of heart rate and the plasma cyclic AMP (cAMP) level to isoproterenol infusion in the supine position were evaluated in 10 POTS patients and 10 age-matched controls.'?,"Yes, it is indirectly supported because the statement describes a study involving isoproterenol infusion in POTS patients, which is relevant to understanding its potential effects on POTS symptoms, such as heart rate response, even though it does not explicitly state that isoproterenol is used as a treatment for POTS." +10687311,Metaproterenol treats obstructive lung disease,1497,ORCIPRENALINE IN TREATMENT OF AIRWAYS OBSTRUCTION IN CHRONIC BRONCHITIS.,True,Is the triple 'Metaproterenol treats obstructive lung disease' supported by the sentence: 'ORCIPRENALINE IN TREATMENT OF AIRWAYS OBSTRUCTION IN CHRONIC BRONCHITIS.'?,"Yes, it is. Metaproterenol is a type of drug called a beta-2 adrenergic agonist, which is used to treat conditions like asthma and chronic bronchitis that involve airway obstruction. Orciprenaline, also known as metaproterenol, is another name for this type of drug. Therefore, the statement that metaproterenol is used to treat airway obstruction in chronic bronchitis is consistent with the information provided in the second statement." +21781034,Bacitracin A treats Infection,1498,"Based on these observations, the combination of CBD and BAC is suggested to be a putative novel treatment in clinical settings for treatment of infections with antibiotic resistant Gram-positive bacteria.",True,"Is the triple 'Bacitracin A treats Infection' supported by the sentence: 'Based on these observations, the combination of CBD and BAC is suggested to be a putative novel treatment in clinical settings for treatment of infections with antibiotic resistant Gram-positive bacteria.'?","Yes, it is indirectly supported because both statements suggest that a substance (CBD in one case, BACitracin in another) can be used to treat infections caused by Gram-positive bacteria. However, it's important to note that they don't directly reference the same specific infection." +17678351,Bacitracin A treats bacterial infectious disease,1499,"Thus, the bacitracin and gramicidin S-based self-assembled nanopeptide ribbon may be a successful ointment formulation for bacterial infection control.",True,"Is the triple 'Bacitracin A treats bacterial infectious disease' supported by the sentence: 'Thus, the bacitracin and gramicidin S-based self-assembled nanopeptide ribbon may be a successful ointment formulation for bacterial infection control.'?","Yes, it is indirectly supported because both statements discuss the antibacterial properties of Bacitracin and its potential use in treating bacterial infections. However, it's important to note that the first statement explicitly mentions Bacitracin A, while the second statement refers to Bacitracin in general. Therefore, it's not a direct correlation but rather a general agreement on the antibacterial properties of Bacitracin." +11891842,Bacitracin A treats burn,1500,"Consensus was found regarding most local (topical) wound care, (SSD for clean non-facial burns, Sulfamylon (mafenide-acetate) for contaminated non-facial burns, Threolone (chloramphenicol 3% and prednisolone 0.5%) or Bacitracin for facial burns, Paraffin gauzes with or without Sulfamylon for donor and graft sites).",True,"Is the triple 'Bacitracin A treats burn' supported by the sentence: 'Consensus was found regarding most local (topical) wound care, (SSD for clean non-facial burns, Sulfamylon (mafenide-acetate) for contaminated non-facial burns, Threolone (chloramphenicol 3% and prednisolone 0.5%) or Bacitracin for facial burns, Paraffin gauzes with or without Sulfamylon for donor and graft sites).'?","Yes, it is indirectly supported because Bacitracin is mentioned as an option for treating facial burns in the given consensus statement. However, it does not explicitly state that Bacitracin A specifically is used for treating burns, nor does it specify that it is used for all types of burns, not just facial ones." +19572117,Ciprofloxacin related to DNA Gyrase,2,Evaluation of granulated fenbendazole (22.2%) against induced and naturally occurring helminth infections in cats.,False,Is the triple 'Ciprofloxacin related to DNA Gyrase' supported by the sentence: 'Evaluation of granulated fenbendazole (22.2%) against induced and naturally occurring helminth infections in cats.'?,"No, that statement does not provide support for the triple Ciprofloxacin-related-to-DNA-Gyrase relationship. The statement discusses the use of granulated fenbendazole against helminth infections in cats, with no mention of Ciprofloxacin, DNA, or gyrase." +26452786,Fenbendazole causes helminthiasis,3,Fenbendazole resistance in O. ostertagi was confirmed with a total treatment failure in reducing worm burden: efficacy of 0%.,False,Is the triple 'Fenbendazole causes helminthiasis' supported by the sentence: 'Fenbendazole resistance in O. ostertagi was confirmed with a total treatment failure in reducing worm burden: efficacy of 0%.'?,"No, it is not directly or indirectly supported. The statement indicates a failure of Fenbendazole to reduce worm burden, suggesting it may not be effective against certain parasites, but it does not link this to a causation of helminthiasis (a condition characterized by parasitic worm infestations)." +22762728,Fenbendazole prevents helminthiasis,4,Symptoms of perianal itching and visualization of visible motile worms persisted for 6 months despite being treated with multiple courses of albendazole causing a lot of frustration and distress to the caregivers.,False,Is the triple 'Fenbendazole prevents helminthiasis' supported by the sentence: 'Symptoms of perianal itching and visualization of visible motile worms persisted for 6 months despite being treated with multiple courses of albendazole causing a lot of frustration and distress to the caregivers.'?,"No, this statement does not support the claim that Fenbendazole prevents helminthiasis, as it discusses treatment with albendazole, not fenbendazole, and does not mention fenbendazole's effectiveness in preventing or treating the condition." +21848143,Albendazole causes helminthiasis,5,"Ovicidal effects of albendazole in human ascariasis, ancylostomiasis and trichuriasis.",True,"Is the triple 'Albendazole causes helminthiasis' supported by the sentence: 'Ovicidal effects of albendazole in human ascariasis, ancylostomiasis and trichuriasis.'?","Yes, it is indirectly supported because ovicidal effects suggest that Albendazole can help in treating certain types of helminthiasis, which is a condition characterized by parasitic worm infections." +25735916,Albendazole affects trichuriasis,6,"A combination of drugs Ivermectin, Diethylcarbamazine citrate and Albendazole is recommended by WHO to accelerate the Global Programme to Eliminate Lymphatic Filariasis (GPELF).",True,"Is the triple 'Albendazole affects trichuriasis' supported by the sentence: 'A combination of drugs Ivermectin, Diethylcarbamazine citrate and Albendazole is recommended by WHO to accelerate the Global Programme to Eliminate Lymphatic Filariasis (GPELF).'?","Yes, the statement does provide some level of indirect support for the idea that Albendazole affects Trichuriasis, as it suggests that Albendazole is used in a treatment regimen for a different parasitic disease, Lymphatic Filariasis, as part of a triple drug therapy that includes Ivermectin and Diethylcarbamazine citrate. This implies that Albendazole has some efficacy against parasitic infections, which could include Trichuriasis, given that it is a broad-spectrum anthelmintic drug often used to treat a variety of parasitic worm infections in humans, including those caused by roundworms, hookworms, and whipworms, which is a type of parasitic infection caused by Trichuris trichiura, also known as whipworm infection, which is a type of Trichuriasis, although it does not directly state that Albendazole is used to treat Trichuriasis specifically, but it does suggest that Albendazole has some level of activity against parasitic worms, which could include those that cause Trichuriasis," +24685635,Albendazole affects filarial elephantiasis,7,Effect of albendazole in experimental toxocariasis of mice.,False,Is the triple 'Albendazole affects filarial elephantiasis' supported by the sentence: 'Effect of albendazole in experimental toxocariasis of mice.'?,"No, that statement does not provide direct support for the claim that Albendazole affects filarial elephantiasis. The sentence you provided discusses experimental toxocariasis in mice, which is a different condition caused by a different parasite (Toxocara canis) than filarial elephantiasis (caused by Wuchereria bancrofti). While it's possible that Albendazole could have similar effects on different parasites, this specific statement does not provide evidence for that claim." +18452252,Albendazole affects toxocariasis,8,"Given the low helminth prevalence in our children, the effect of albendazole on malaria is likely to be direct.",False,"Is the triple 'Albendazole affects toxocariasis' supported by the sentence: 'Given the low helminth prevalence in our children, the effect of albendazole on malaria is likely to be direct.'?","No, it is not directly supported because it refers to malaria, not toxocariasis. However, it does suggest that albendazole can have a direct effect on certain conditions, implying that it could potentially have an indirect effect on toxocariasis if it were found to be present in significant numbers in your children." +16658505,Albendazole affects malaria,9,"Mass co-administration of ivermectin and albendazole by the LFEP had a significant effect on STH, which was further amplified by treatment with praziquantel and albendazole 4 months later.",False,"Is the triple 'Albendazole affects malaria' supported by the sentence: 'Mass co-administration of ivermectin and albendazole by the LFEP had a significant effect on STH, which was further amplified by treatment with praziquantel and albendazole 4 months later.'?","No, this statement does not directly support that Albendazole affects malaria, as it discusses its effects on Soil Transmitted Helminths (STH) when combined with other drugs, not its effects on Malaria specifically." +13946207,Albendazole affects helminthiasis,10,The effect of single dose ivermectin alone or in combination with albendazole on Wuchereria bancrofti infection in primary school children in Tanzania.,False,Is the triple 'Albendazole affects helminthiasis' supported by the sentence: 'The effect of single dose ivermectin alone or in combination with albendazole on Wuchereria bancrofti infection in primary school children in Tanzania.'?,"No, it is not directly supported because it discusses Ivermectin's effect on Wuchereria bancrofti infection, not Albendazole's effect on helminthiasis. However, it does imply that Albendazole may have an effect on other types of parasitic infections, given its use in combination with Ivermectin in this study." +11239060,Albendazole affects filariasis,11,"Additionally, compared with albendazole, it resulted in a significant reduction in adult worm and total larval counts; moreover, it caused a decrease in the number of larvae deposited in muscles, with a highly significant decrease in the inflammatory cell infiltrate around the larvae and a considerable decrease in the expression of the angiogenic marker vascular endothelial growth factor in muscles.",True,"Is the triple 'Albendazole affects filariasis' supported by the sentence: 'Additionally, compared with albendazole, it resulted in a significant reduction in adult worm and total larval counts; moreover, it caused a decrease in the number of larvae deposited in muscles, with a highly significant decrease in the inflammatory cell infiltrate around the larvae and a considerable decrease in the expression of the angiogenic marker vascular endothelial growth factor in muscles.'?","Yes, the statement does provide some level of support for the idea that Albendazole affects filariasis. It mentions that Albendazole leads to a reduction in adult worms, larval counts, larvae deposited in muscles, inflammatory cell infiltrate around larvae, and expression of vascular endothelial growth factor in muscles - all of which could be considered aspects of fighting against filariasis. However, it's important to note that this is an indirect support as it doesn't explicitly state that Albendazole treats or cures filariasis." +24729219,Albendazole disrupts helminthiasis,12,"Quarterly albendazole during childhood was associated with reduced incidence of clinical malaria (HR 0.85 (95% CI 0.73-0.98), p = 0.03).",False,"Is the triple 'Albendazole disrupts helminthiasis' supported by the sentence: 'Quarterly albendazole during childhood was associated with reduced incidence of clinical malaria (HR 0.85 (95% CI 0.73-0.98), p = 0.03).'?","No, it is not directly related because it talks about clinical malaria, not helminthiasis specifically. However, it could be interpreted as supporting it indirectly since both malaria and helminthiasis can be considered neglected tropical diseases, which often overlap in their geographical distribution and risk factors, making it plausible that a drug like Albendazole could have a broader impact on multiple tropical diseases in a region, including helminthiasis." +16658503,Albendazole disrupts malaria,13,CONCLUSIONS: Mebendazole and albendazole showed reduced efficacy against Ascaris lumbricoides and hookworm infections at the recommended doses.,False,Is the triple 'Albendazole disrupts malaria' supported by the sentence: 'CONCLUSIONS: Mebendazole and albendazole showed reduced efficacy against Ascaris lumbricoides and hookworm infections at the recommended doses.'?,"No, it is not directly supported because the conclusion is about reduced efficacy against certain types of infections, not about disruption of malaria specifically." +13637338,Albendazole disrupts Hookworm Infections,14,Evaluation of effectiveness of diethylcarbamazine/albendazole combination in reduction of Wuchereria bancrofti infection using multiple infection parameters.,True,Is the triple 'Albendazole disrupts Hookworm Infections' supported by the sentence: 'Evaluation of effectiveness of diethylcarbamazine/albendazole combination in reduction of Wuchereria bancrofti infection using multiple infection parameters.'?,"Yes, it is indirectly supported. The sentence mentions that albendazole is used in a combination treatment to reduce Wuchereria bancrofti infection, which suggests that albendazole can have an impact on worm infections, thus supporting the idea that it could also disrupt hookworm infections. However, it's important to note that hookworm is a different species than Wuchereria bancrofti, so direct support would require a specific study on albendazole's effect on hookworm infections." +15248433,Albendazole prevents filariasis,15,"Our evaluation suggests that although additional studies are needed to determine optimal treatment regimens for intestinal parasites, especially among young children and pregnant women, a five-day course of pre-departure albendazole was effective in reducing helminthic infection in treated refugees.",True,"Is the triple 'Albendazole prevents filariasis' supported by the sentence: 'Our evaluation suggests that although additional studies are needed to determine optimal treatment regimens for intestinal parasites, especially among young children and pregnant women, a five-day course of pre-departure albendazole was effective in reducing helminthic infection in treated refugees.'?","Yes, it is indirectly supported. The given sentence mentions that a five-day course of pre-departure albendazole was effective in reducing helminthic infection in treated refugees. Filariasis is a type of helminthic infection, so this statement implies that albendazole can be effective in preventing or treating filariasis. However, it does not directly mention filariasis, hence it's an indirect support." +13732336,Albendazole prevents helminthiasis,16,"The purpose of this study was the development and validation of an LC-MS-MS method for simultaneous analysis of ibuprofen (IBP), 2-hydroxyibuprofen (2-OH-IBP) enantiomers, and carboxyibuprofen (COOH-IBP) stereoisomers in fungi culture medium, to investigate the ability of some endophytic fungi to biotransform the chiral drug IBP into its metabolites.",False,"Is the triple 'Albendazole prevents helminthiasis' supported by the sentence: 'The purpose of this study was the development and validation of an LC-MS-MS method for simultaneous analysis of ibuprofen (IBP), 2-hydroxyibuprofen (2-OH-IBP) enantiomers, and carboxyibuprofen (COOH-IBP) stereoisomers in fungi culture medium, to investigate the ability of some endophytic fungi to biotransform the chiral drug IBP into its metabolites.'?","No, it is not directly nor indirectly supported, as there is no mention of Albendazole, helminthiasis, or any related topics in the provided statement about a method for analyzing ibuprofen metabolites in fungi culture medium." +15316470,Ibuprofen subclass of 2-Hydroxyibuprofen,17,"AIMS: To carry out a randomized clinical trial to compare the effect of palmitoylethanolamide (PEA) versus ibuprofen, a nonsteroidal anti-inflammatory drug (NSAID), for pain relief in temporomandibular joint (TMJ) osteoarthritis or arthralgia.",False,"Is the triple 'Ibuprofen subclass of 2-Hydroxyibuprofen' supported by the sentence: 'AIMS: To carry out a randomized clinical trial to compare the effect of palmitoylethanolamide (PEA) versus ibuprofen, a nonsteroidal anti-inflammatory drug (NSAID), for pain relief in temporomandibular joint (TMJ) osteoarthritis or arthralgia.'?","No, the statement does not support that Ibuprofen is a subclass of 2-Hydroxyibuprofen. It also does not directly support that Ibuprofen is a subclass of PEA (palmitoylethanolamide). It does, however, support that Ibuprofen is a NSAID (nonsteroidal anti-inflammatory drug) being compared to PEA for pain relief in temporomandibular joint osteoarthritis or arthralgia." +16265626,Ibuprofen related to Arthralgia,18,"We investigated the analgesic efficacy of single doses of ibuprofen, tramadol and pregabalin in menthol-evoked cold pain in a randomized, placebo-controlled four-way cross-over study in 20 healthy volunteers.",True,"Is the triple 'Ibuprofen related to Arthralgia' supported by the sentence: 'We investigated the analgesic efficacy of single doses of ibuprofen, tramadol and pregabalin in menthol-evoked cold pain in a randomized, placebo-controlled four-way cross-over study in 20 healthy volunteers.'?","Yes, it is indirectly supported because the mention of ibuprofen in a study about pain (analgesic efficacy) suggests a potential link to arthralgia, which is joint pain, as ibuprofen is a common pain reliever often used for arthritis-related pain. However, the study itself does not directly investigate this relationship." +14582794,Ibuprofen related to Pain,19,Double blind study on emorfazone and ibuprofen in dental pain and inflammation.,True,Is the triple 'Ibuprofen related to Pain' supported by the sentence: 'Double blind study on emorfazone and ibuprofen in dental pain and inflammation.'?,"Yes, it is indirectly supported because both Ibuprofen and Emorfazone were used in a dental pain and inflammation study, implying a connection between Ibuprofen and pain relief." +11440746,Ibuprofen related to Toothache,20,Glucosamine sulfate compared to ibuprofen in osteoarthritis of the knee.,False,Is the triple 'Ibuprofen related to Toothache' supported by the sentence: 'Glucosamine sulfate compared to ibuprofen in osteoarthritis of the knee.'?,"No, the statement does not provide any support for a relationship between Ibuprofen and toothache, nor does it mention Glucosamine sulfate's relation to toothache. The statement discusses Glucosamine sulfate in comparison to Ibuprofen in treating osteoarthritis of the knee." +9106384,Ibuprofen related to osteoarthritis,21,INTRODUCTION: The anti-inflammatory and anticoagulant effects of ibuprofen and heparin may enhance skin perfusion in cutaneous scald burns.,False,Is the triple 'Ibuprofen related to osteoarthritis' supported by the sentence: 'INTRODUCTION: The anti-inflammatory and anticoagulant effects of ibuprofen and heparin may enhance skin perfusion in cutaneous scald burns.'?,"No, the statement does not provide support for a direct or indirect relationship between ibuprofen and osteoarthritis. It discusses the effects of ibuprofen on skin perfusion in cutaneous scald burns, not on osteoarthritis." +8106985,Ibuprofen related to burn,22,"CONCLUSIONS: Ibuprofen-induced patent ductus arteriosus closure improved pulmonary mechanics, decreased total lung water, increased epithelial sodium channel expression, and decreased the detrimental effects of preterm birth on alveolarization.",False,"Is the triple 'Ibuprofen related to burn' supported by the sentence: 'CONCLUSIONS: Ibuprofen-induced patent ductus arteriosus closure improved pulmonary mechanics, decreased total lung water, increased epithelial sodium channel expression, and decreased the detrimental effects of preterm birth on alveolarization.'?","No, the statement does not provide direct evidence that ibuprofen is related to burns. It discusses the effects of ibuprofen on patent ductus arteriosus closure, pulmonary mechanics, total lung water, epithelial sodium channel expression, and alveolarization in preterm births, but it does not mention anything about burns." +13726345,Ibuprofen causes patent ductus arteriosus,23,Protein profile in neuroblastoma cells incubated with S- and R-enantiomers of ibuprofen by iTRAQ-coupled 2-D LC-MS/MS analysis: possible action of induced proteins on Alzheimer's disease.,False,Is the triple 'Ibuprofen causes patent ductus arteriosus' supported by the sentence: 'Protein profile in neuroblastoma cells incubated with S- and R-enantiomers of ibuprofen by iTRAQ-coupled 2-D LC-MS/MS analysis: possible action of induced proteins on Alzheimer's disease.'?,"No, this statement does not provide direct or indirect support for the claim that Ibuprofen causes patent ductus arteriosus. The study referenced is about the protein profile in neuroblastoma cells incubated with S- and R-enantiomers of ibuprofen, and possible actions of induced proteins on Alzheimer's disease, which is not related to patent ductus arteriosus." +13653982,Ibuprofen causes Alzheimer disease,24,Protective effect of glucosamine against ibuprofen-induced peptic ulcer in rats.,False,Is the triple 'Ibuprofen causes Alzheimer disease' supported by the sentence: 'Protective effect of glucosamine against ibuprofen-induced peptic ulcer in rats.'?,"No, it is not directly nor indirectly supported, as there is no mention or implication about ibuprofen causing Alzheimer's disease in this statement about a protective effect of glucosamine on ibuprofen-induced peptic ulcers in rats." +13133316,Ibuprofen causes peptic ulcer disease,25,Ibuprofen-induced fever in Sjogren's syndrome.,False,Is the triple 'Ibuprofen causes peptic ulcer disease' supported by the sentence: 'Ibuprofen-induced fever in Sjogren's syndrome.'?,"No, it is not directly or indirectly supported, as the given statement does not mention any correlation to peptic ulcer disease." +12641386,Ibuprofen causes Fever,26,There have been no prior definite cases reported of ibuprofen-induced pancreatitis.,False,Is the triple 'Ibuprofen causes Fever' supported by the sentence: 'There have been no prior definite cases reported of ibuprofen-induced pancreatitis.'?,"No, it is not directly or indirectly supported. In fact, it seems unrelated, as fever is not mentioned in the given statement about ibuprofen-induced pancreatitis." +12482174,Ibuprofen causes pancreatitis,27,"RESULTS: None of the studies established any of the COX-2 inhibitors as clearly better than ibuprofen, the current gold standard for the treatment of surgically induced dental pain.",False,"Is the triple 'Ibuprofen causes pancreatitis' supported by the sentence: 'RESULTS: None of the studies established any of the COX-2 inhibitors as clearly better than ibuprofen, the current gold standard for the treatment of surgically induced dental pain.'?","No, it is not directly or indirectly supported by that statement, which actually suggests that ibuprofen is still considered a standard in pain treatment, without implying it has negative side effects like causing pancreatitis." +12438812,Ibuprofen causes Toothache,28,Noncardiogenic pulmonary edema due to ibuprofen.,False,Is the triple 'Ibuprofen causes Toothache' supported by the sentence: 'Noncardiogenic pulmonary edema due to ibuprofen.'?,"No, it is not directly or indirectly supported, as noncardiogenic pulmonary edema is not related to toothache, nor is it a direct consequence of taking ibuprofen. Ibuprofen can have various side effects, including noncardiogenic pulmonary edema, but it does not cause toothaches as per your statement." +12079834,Ibuprofen causes adult acute respiratory distress syndrome,29,"In a double-blind cross-over study on 22 healthy subjects the analgesic efficacies of the antipyretic analgesic drugs ibuprofen, dipyrone and paracetamol were tested against placebo using a model of experimentally induced pain.",False,"Is the triple 'Ibuprofen causes adult acute respiratory distress syndrome' supported by the sentence: 'In a double-blind cross-over study on 22 healthy subjects the analgesic efficacies of the antipyretic analgesic drugs ibuprofen, dipyrone and paracetamol were tested against placebo using a model of experimentally induced pain.'?","No, this statement does not provide support for the claim that ibuprofen causes adult acute respiratory distress syndrome, directly or indirectly. It discusses a study on the analgesic efficacy of ibuprofen, dipyrone, paracetamol, and placebo in healthy subjects, but it does not mention or imply any adverse effects such as adult acute respiratory distress syndrome." +11157616,Ibuprofen causes Pain,30,Unaltered ibuprofen-induced faecal blood loss upon coadministration of moclobemide.,False,Is the triple 'Ibuprofen causes Pain' supported by the sentence: 'Unaltered ibuprofen-induced faecal blood loss upon coadministration of moclobemide.'?,"No, it is not directly or indirectly supported. The statement about ibuprofen causing pain is not mentioned in the provided sentence about faecal blood loss upon coadministration of moclobemide." +10429873,Ibuprofen causes Hemorrhage,31,The C5a antagonist (1 or 3 mg/kg/day) and/or ibuprofen (30 mg/kg/day) were administered orally on a daily basis either before or after arthritis induction.,False,Is the triple 'Ibuprofen causes Hemorrhage' supported by the sentence: 'The C5a antagonist (1 or 3 mg/kg/day) and/or ibuprofen (30 mg/kg/day) were administered orally on a daily basis either before or after arthritis induction.'?,"No, it is not directly supported. The given statement indicates that ibuprofen was administered, but it does not mention any correlation between ibuprofen, hemorrhage, and arthritis induction, which is necessary to support the claim 'Ibuprofen causes Hemorrhage'." +9800201,Ibuprofen causes arthritic joint disease,32,RESULTS: Ketoprofen 50 mg t.d.s. suppressed prostaglandin synthesis to a significantly greater extent than ibuprofen and caused significantly more gastroduodenal injury.,True,Is the triple 'Ibuprofen causes arthritic joint disease' supported by the sentence: 'RESULTS: Ketoprofen 50 mg t.d.s. suppressed prostaglandin synthesis to a significantly greater extent than ibuprofen and caused significantly more gastroduodenal injury.'?,"Yes, it is indirectly supported because the results suggest that ibuprofen may cause more gastroduodenal injury than ketoprofen, which could potentially contribute to joint disease over time. However, it's important to note that this study specifically refers to gastroduodenal injury, not arthritic joint disease." +8163776,Ibuprofen causes injury,33,The duration of action of sustained-release ibuprofen ('Brufen Retard') was investigated in a 14-day double-blind study involving 14 osteoarthritis and 10 rheumatoid arthritis patients.,False,Is the triple 'Ibuprofen causes injury' supported by the sentence: 'The duration of action of sustained-release ibuprofen ('Brufen Retard') was investigated in a 14-day double-blind study involving 14 osteoarthritis and 10 rheumatoid arthritis patients.'?,"No, this statement does not provide any evidence to support that Ibuprofen causes injury, either directly or indirectly. It merely discusses a study on the duration of action of a specific formulation of Ibuprofen (Brufen Retard) in osteoarthritis and rheumatoid arthritis patients." +26701175,Ibuprofen affects rheumatoid arthritis,34,This study attempts to investigate the effect of ibuprofen on reducing eye pain and migraine headaches caused by trochleitis.,True,Is the triple 'Ibuprofen affects rheumatoid arthritis' supported by the sentence: 'This study attempts to investigate the effect of ibuprofen on reducing eye pain and migraine headaches caused by trochleitis.'?,"Yes, it is indirectly supported because ibuprofen is being investigated for its effect on pain reduction, which is a symptom of rheumatoid arthritis. However, the primary focus of the study mentioned is eye pain and migraine headaches caused by trochleitis, not rheumatoid arthritis specifically." +24384432,Ibuprofen affects migraine disorder,35,"Ibuprofen suppresses the production of various pro-inflammatory cytokines that are implicated in the ""cytokine storm"" and subsequent ARDS in COVID-19 disease.",False,"Is the triple 'Ibuprofen affects migraine disorder' supported by the sentence: 'Ibuprofen suppresses the production of various pro-inflammatory cytokines that are implicated in the ""cytokine storm"" and subsequent ARDS in COVID-19 disease.'?","No, it is not directly supported because it discusses a different topic (COVID-19 disease) and does not mention migraines explicitly. However, it does imply that Ibuprofen has anti-inflammatory effects, which could potentially be relevant to its effects on migraines, but this would be an indirect inference, not a direct one based on the given sentence alone." +23500890,Ibuprofen affects adult acute respiratory distress syndrome,36,"After adjusting for covariates, the risk of BPD was associated independently with ibuprofen exposure (odds ratios (OR) 2.296, 95% confidence interval (CI): 1.166-4.522, p = 0.016).",False,"Is the triple 'Ibuprofen affects adult acute respiratory distress syndrome' supported by the sentence: 'After adjusting for covariates, the risk of BPD was associated independently with ibuprofen exposure (odds ratios (OR) 2.296, 95% confidence interval (CI): 1.166-4.522, p = 0.016).'?","No, this statement does not directly support the claim that ibuprofen affects adult acute respiratory distress syndrome (ARDS). The sentence you provided discusses the association between ibuprofen exposure and bronchopulmonary dysplasia (BPD) in infants, not ARDS in adults. Therefore, it does not provide evidence for or against the effect of ibuprofen on ARDS in adults." +21214366,Ibuprofen affects bronchopulmonary dysplasia,37,The opposite effect of ibuprofen on ethanol-induced cognitive impairment as measured by two lateralized functions is consistent with the reports in tissue and animal models that central nervous system effects of ethanol may be mediated at least in part by prostaglandins.,False,Is the triple 'Ibuprofen affects bronchopulmonary dysplasia' supported by the sentence: 'The opposite effect of ibuprofen on ethanol-induced cognitive impairment as measured by two lateralized functions is consistent with the reports in tissue and animal models that central nervous system effects of ethanol may be mediated at least in part by prostaglandins.'?,"No, it is not directly supported, as this statement discusses the central nervous system effects of ethanol, not those related to bronchopulmonary dysplasia. However, it does suggest that ibuprofen may have an impact on prostaglandins, which could potentially have implications for various bodily systems, including those affected by bronchopulmonary dysplasia." +20886939,Ibuprofen affects Cognitive impairment,38,"On post-partum day five, she began complaining of headaches, initially responsive to ibuprofen but eventually worsened with no relief.",True,"Is the triple 'Ibuprofen affects Cognitive impairment' supported by the sentence: 'On post-partum day five, she began complaining of headaches, initially responsive to ibuprofen but eventually worsened with no relief.'?","Yes, it can be inferred that ibuprofen initially had an effect on her headaches, but it did not prevent the worsening of her symptoms over time. This suggests that ibuprofen might not be a long-term solution for her condition, which could be related to cognitive impairment. However, this is an indirect inference and does not directly support the statement that ibuprofen affects cognitive impairment." +18977843,Ibuprofen affects Headache,39,"Because ibuprofen protects from septic lung injury, we studied the effect of ibuprofen in oxidant lung injury from phosgene.",False,"Is the triple 'Ibuprofen affects Headache' supported by the sentence: 'Because ibuprofen protects from septic lung injury, we studied the effect of ibuprofen in oxidant lung injury from phosgene.'?","No, it is not directly or indirectly supported because there is no mention of headaches in that context, and it focuses on a different medical issue, which is lung injuries, specifically those caused by phosgene-induced oxidant damage, rather than addressing headaches." +15746938,Ibuprofen affects injury,40,The efficacy and tolerance of ibuprofen retard at a dose of 2 x 800 mg daily was investigated in an open multicenter study over a period of 3 weeks on 7931 out-patients with activated degenerative joint disease and/or extraarticular rheumatic symptoms.,False,Is the triple 'Ibuprofen affects injury' supported by the sentence: 'The efficacy and tolerance of ibuprofen retard at a dose of 2 x 800 mg daily was investigated in an open multicenter study over a period of 3 weeks on 7931 out-patients with activated degenerative joint disease and/or extraarticular rheumatic symptoms.'?,"No, this statement does not provide direct evidence to support that Ibuprofen affects injury, as it discusses the efficacy, tolerance, and dosage in patients with joint disease and rheumatic symptoms, not its effect on injuries specifically." +13826486,Ibuprofen affects osteoarthritis,41,"Overall, we found no relation between regular aspirin use and cognitive decline, but long-term use of ibuprofen may be related to decreased rates of cognitive decline in older persons.",True,"Is the triple 'Ibuprofen affects osteoarthritis' supported by the sentence: 'Overall, we found no relation between regular aspirin use and cognitive decline, but long-term use of ibuprofen may be related to decreased rates of cognitive decline in older persons.'?","Yes, it is indirectly supported because it suggests that ibuprofen may have an impact on cognitive decline in older individuals, which could potentially be related to diseases like osteoarthritis as it is a condition often experienced by this demographic. However, it does not directly state that ibuprofen affects osteoarthritis." +13584223,Ibuprofen affects Cognitive impairment,42,"Subdiaphragmatic vagotomy or 7-nitroindazole reduced, icatibant, DALBK, IL-1ra, aminoguanidine and dipyrone abolished, while ibuprofen and celecoxib failed to affect Tsv-induced fever.",False,"Is the triple 'Ibuprofen affects Cognitive impairment' supported by the sentence: 'Subdiaphragmatic vagotomy or 7-nitroindazole reduced, icatibant, DALBK, IL-1ra, aminoguanidine and dipyrone abolished, while ibuprofen and celecoxib failed to affect Tsv-induced fever.'?","No, this statement does not provide direct evidence to support that Ibuprofen affects cognitive impairment, as it discusses Tsv-induced fever, not cognitive impairment." +12659717,Ibuprofen affects Fever,43,Reduced incidence of gastroduodenal ulcers associated with lumiracoxib compared with ibuprofen in patients with rheumatoid arthritis.,False,Is the triple 'Ibuprofen affects Fever' supported by the sentence: 'Reduced incidence of gastroduodenal ulcers associated with lumiracoxib compared with ibuprofen in patients with rheumatoid arthritis.'?,"No, it is not directly or indirectly supported because it talks about a different topic, which is lumiracoxib affecting gastroduodenal ulcers, not ibuprofen affecting fever." +11207850,Ibuprofen affects peptic ulcer disease,44,It was also investigated whether the use of ibuprofen or paracetamol would influence the amount of surgical bleeding.,True,Is the triple 'Ibuprofen affects peptic ulcer disease' supported by the sentence: 'It was also investigated whether the use of ibuprofen or paracetamol would influence the amount of surgical bleeding.'?,"Yes, it is indirectly supported because both Ibuprofen and paracetamol can affect bleeding, which is a symptom of peptic ulcers, so their usage could potentially influence surgical bleeding in patients with these conditions. However, it does not directly address the impact on peptic ulcer disease itself." +11159990,Ibuprofen affects Hemorrhage,45,"In a randomised, placebo-controlled, double-blind trial of prophylaxis with ibuprofen, the rate of patent ductus arteriosus associated with ibuprofen was 19% compared with 42% with placebo.",True,"Is the triple 'Ibuprofen affects Hemorrhage' supported by the sentence: 'In a randomised, placebo-controlled, double-blind trial of prophylaxis with ibuprofen, the rate of patent ductus arteriosus associated with ibuprofen was 19% compared with 42% with placebo.'?","Yes, this statement does provide some level of support for the idea that ibuprofen may affect hemorrhage, but it's important to note that it's not a direct correlation. The study is about prophylaxis with ibuprofen and its effect on patent ductus arteriosus (a condition where a blood vessel in babies doesn't close as it should after birth), not specifically on hemorrhage. However, since hemorrhage can be a complication of patent ductus arteriosus, one could infer that ibuprofen might have an impact on hemorrhage rates in this context." +10170540,Ibuprofen affects patent ductus arteriosus,46,"The purpose of this study was to examine the effects of ibuprofen on delayed onset muscle soreness (DOMS), indirect markers of muscle damage and muscular performance.",False,"Is the triple 'Ibuprofen affects patent ductus arteriosus' supported by the sentence: 'The purpose of this study was to examine the effects of ibuprofen on delayed onset muscle soreness (DOMS), indirect markers of muscle damage and muscular performance.'?","No, it is not directly or indirectly supported because the focus of that study is on delayed onset muscle soreness (DOMS), markers of muscle damage, and muscular performance, not on patent ductus arteriosus." +10026104,Ibuprofen affects Myalgia,47,CONCLUSIONS: Pretreatment with ibuprofen before elective total hip surgery increases the perioperative blood loss significantly.,True,Is the triple 'Ibuprofen affects Myalgia' supported by the sentence: 'CONCLUSIONS: Pretreatment with ibuprofen before elective total hip surgery increases the perioperative blood loss significantly.'?,"Yes, it is indirectly supported because increased perioperative blood loss can be a symptom of myalgia, which is a muscle pain that ibuprofen, as a pain reliever, is designed to alleviate. However, this conclusion does not directly state that ibuprofen affects myalgia, but it suggests a potential correlation." +9889792,Ibuprofen affects Hemorrhage,48,"The data suggest that nimesulide and ibuprofen, in addition to their anti-inflammatory and analgesic benefits, may also have a protective effect in osteoarthritis through the inhibition of apoptosis in chondrocytes.",False,"Is the triple 'Ibuprofen affects Hemorrhage' supported by the sentence: 'The data suggest that nimesulide and ibuprofen, in addition to their anti-inflammatory and analgesic benefits, may also have a protective effect in osteoarthritis through the inhibition of apoptosis in chondrocytes.'?","No, this statement does not provide direct evidence of a relationship between Ibuprofen and hemorrhage. It discusses the potential protective effects of Ibuprofen and another drug, nimesulide, on chondrocytes in osteoarthritis through inhibition of apoptosis, but it does not mention hemorrhage." +8819538,Ibuprofen affects osteoarthritis,49,Pretreatment with ibuprofen blocked the fever induced by RANTES.,False,Is the triple 'Ibuprofen affects osteoarthritis' supported by the sentence: 'Pretreatment with ibuprofen blocked the fever induced by RANTES.'?,"No, it is not directly nor indirectly supported, as this statement discusses fever reduction, not its effects on osteoarthritis, which is a specific joint disease." +8421263,Ibuprofen affects Fever,50,This study evaluated whether administration of the pharmacologically active S(+)-isomer of ibuprofen suppresses acute pain and plasma beta-endorphin levels in the oral surgery model of acute pain.,False,Is the triple 'Ibuprofen affects Fever' supported by the sentence: 'This study evaluated whether administration of the pharmacologically active S(+)-isomer of ibuprofen suppresses acute pain and plasma beta-endorphin levels in the oral surgery model of acute pain.'?,"No, it is not directly related because this statement does not address fever, but rather acute pain and plasma beta-endorphin levels in oral surgery models." +27630106,Ibuprofen disrupts Acute Pain,51,"On the other hand, in subgroup B, no improvement in flexibility or reduction in muscle soreness was found in patients who took ibuprofen.",True,"Is the triple 'Ibuprofen disrupts Acute Pain' supported by the sentence: 'On the other hand, in subgroup B, no improvement in flexibility or reduction in muscle soreness was found in patients who took ibuprofen.'?","Yes, it is. The absence of improvement in flexibility or reduction in muscle soreness suggests that ibuprofen did not effectively manage acute pain in this particular subgroup (subgroup B). This supports the idea that ibuprofen can disrupt acute pain, but it also shows that its effectiveness can vary among different individuals or conditions." +23399675,Ibuprofen disrupts Myalgia,52,"This is termed, Celery Seed Extract (CSE) and has been found to be at least as effective as aspirin, ibuprofen, and naproxen in suppressing arthritis in a model of polyarthritis.",True,"Is the triple 'Ibuprofen disrupts Myalgia' supported by the sentence: 'This is termed, Celery Seed Extract (CSE) and has been found to be at least as effective as aspirin, ibuprofen, and naproxen in suppressing arthritis in a model of polyarthritis.'?","Yes, it can be interpreted as indirect support for the statement that ibuprofen disrupts myalgia (muscle pain). The sentence you provided suggests that celery seed extract (CSE) has similar effects to ibuprofen in reducing pain in a polyarthritis model. Therefore, if ibuprofen can help with pain in this model, it could be inferred that ibuprofen could also help with myalgia in a broader sense. However, it's important to note that this is an inference based on a generalized interpretation of the provided sentence; it doesn't directly state that ibuprofen disrupts myalgia." +18599970,Ibuprofen disrupts arthritic joint disease,53,INTRODUCTION: Hospitalized patients are often unable to ingest or tolerate oral antipyretics and recently an aqueous formulation of intravenous (IV) ibuprofen was approved by the US-FDA for the reduction of fever in adults.,False,Is the triple 'Ibuprofen disrupts arthritic joint disease' supported by the sentence: 'INTRODUCTION: Hospitalized patients are often unable to ingest or tolerate oral antipyretics and recently an aqueous formulation of intravenous (IV) ibuprofen was approved by the US-FDA for the reduction of fever in adults.'?,"No, this statement does not directly support that ibuprofen disrupts arthritic joint disease, but it does support that ibuprofen can be administered intravenously, which could be relevant to treating arthritis." +15072611,Ibuprofen disrupts Fever,54,"OBJECTIVES: This study compared the analgesic effectiveness of acetaminophen-codeine with that of ibuprofen for children with acute traumatic extremity pain, with the hypothesis that the two medications would demonstrate equivalent reduction in pain scores in an emergency department (ED) setting.",True,"Is the triple 'Ibuprofen disrupts Fever' supported by the sentence: 'OBJECTIVES: This study compared the analgesic effectiveness of acetaminophen-codeine with that of ibuprofen for children with acute traumatic extremity pain, with the hypothesis that the two medications would demonstrate equivalent reduction in pain scores in an emergency department (ED) setting.'?","Yes, it is indirectly supported, as this passage suggests that ibuprofen is being used for pain relief in an emergency department setting, which could imply that it is used to reduce fever as well, given that fever is often a symptom of pain in children with acute traumatic extremity pain. However, it does not directly state that ibuprofen disrupts fever, but rather implies its use for pain relief in a broader sense." +14486259,Ibuprofen disrupts Pain,55,"Thus, the anti-inflammatory drug ibuprofen, which has been associated with reduced AD risk in human epidemiological studies, can significantly delay some forms of AD pathology, including amyloid deposition, when administered early in the disease course of a transgenic mouse model of AD.",True,"Is the triple 'Ibuprofen disrupts Pain' supported by the sentence: 'Thus, the anti-inflammatory drug ibuprofen, which has been associated with reduced AD risk in human epidemiological studies, can significantly delay some forms of AD pathology, including amyloid deposition, when administered early in the disease course of a transgenic mouse model of AD.'?","Yes, it is indirectly supported. The statement suggests that Ibuprofen has been associated with reduced Alzheimer's Disease (AD) risk in human studies and can delay some forms of AD pathology in a transgenic mouse model of AD. This implies that Ibuprofen could potentially disrupt pain related to AD pathology, as pain is often associated with inflammation and Ibuprofen is an anti-inflammatory drug. However, it's important to note that this is an inference and not explicitly stated in the provided sentence." +8331095,Ibuprofen disrupts Alzheimer disease,56,"The hypoxia, hypertension and increased prostanoids were prevented using ibuprofen.",True,"Is the triple 'Ibuprofen disrupts Alzheimer disease' supported by the sentence: 'The hypoxia, hypertension and increased prostanoids were prevented using ibuprofen.'?","Yes, it is indirectly supported. The sentence suggests that ibuprofen can prevent certain conditions (hypoxia, hypertension, and increased prostanoids) that have been linked to Alzheimer's disease. However, it does not directly state that ibuprofen disrupts Alzheimer's disease." +25657729,Ibuprofen prevents hypertensive disorder,57,"The Effect of Ibuprofen Dosing Interval on Post-Tonsillectomy Outcomes in Children: A Quality Improvement Study.OBJECTIVE: In this Quality Improvement (QI project) it was hypothesized that an increase in dosing intervals for postoperative analgesia when alternating Ibuprofen and Acetaminophen would reduce post-tonsillectomy hemorrhage (PTH) rates for those undergoing tonsillectomies with or without adenoidectomy, while maintaining the standard of postoperative analgesia and reducing visits to the Emergency Room (ER) for reasons other than PTH.",False,"Is the triple 'Ibuprofen prevents hypertensive disorder' supported by the sentence: 'The Effect of Ibuprofen Dosing Interval on Post-Tonsillectomy Outcomes in Children: A Quality Improvement Study.OBJECTIVE: In this Quality Improvement (QI project) it was hypothesized that an increase in dosing intervals for postoperative analgesia when alternating Ibuprofen and Acetaminophen would reduce post-tonsillectomy hemorrhage (PTH) rates for those undergoing tonsillectomies with or without adenoidectomy, while maintaining the standard of postoperative analgesia and reducing visits to the Emergency Room (ER) for reasons other than PTH.'?","No, this study does not directly support the statement that ""Ibuprofen prevents hypertensive disorder"". The study focuses on the effect of Ibuprofen dosing intervals on post-tonsillectomy outcomes in children, including reducing post-tonsillectomy hemorrhage rates, maintaining postoperative analgesia, and reducing visits to the Emergency Room for reasons other than PTH." +22159382,Ibuprofen prevents Hemorrhage,58,Studies show that ibuprofen demonstrates superior efficacy in fever reduction compared to acetaminophen.,False,Is the triple 'Ibuprofen prevents Hemorrhage' supported by the sentence: 'Studies show that ibuprofen demonstrates superior efficacy in fever reduction compared to acetaminophen.'?,"No, this statement does not provide any evidence for the claim that 'ibuprofen prevents hemorrhage'. It only suggests that ibuprofen might be more effective in reducing fever than acetaminophen, based on some studies." +22123299,Ibuprofen prevents Fever,59,IV Ibuprofen for Prevention of Post-Ercp Pancreatitis in Children: A Randomized Placebo-Controlled Feasibility Study.,True,Is the triple 'Ibuprofen prevents Fever' supported by the sentence: 'IV Ibuprofen for Prevention of Post-Ercp Pancreatitis in Children: A Randomized Placebo-Controlled Feasibility Study.'?,"Yes, it is indirectly supported because the study mentions that ibuprofen was used to prevent a certain condition (post-ERCP pancreatitis in children), which implies that it can help reduce fever, a common symptom associated with inflammation, as fever is one way the body responds to illnesses like pancreatitis. However, it is essential to note that this is an inference, as fever is not explicitly mentioned in the study title you provided." +21354514,Ibuprofen prevents pancreatitis,60,Altitude Sickness Prevention with Ibuprofen Relative to Acetazolamide.,False,Is the triple 'Ibuprofen prevents pancreatitis' supported by the sentence: 'Altitude Sickness Prevention with Ibuprofen Relative to Acetazolamide.'?,"No, it is not directly or indirectly supported, as there is no mention of pancreatitis in that given title about altitude sickness prevention using ibuprofen in comparison to acetazolamide." +20691057,Ibuprofen prevents altitude sickness,61,"In conclusion, prednisone, ibuprofen and betamethasone may prevent OA by suppressing the expression of IL-6 and IL-8, subsequently inactivating NF-kappaB and STAT3 pathways, and ultimately, leading to decreased levels of collagen I, MMP-1, and MMP-13.",False,"Is the triple 'Ibuprofen prevents altitude sickness' supported by the sentence: 'In conclusion, prednisone, ibuprofen and betamethasone may prevent OA by suppressing the expression of IL-6 and IL-8, subsequently inactivating NF-kappaB and STAT3 pathways, and ultimately, leading to decreased levels of collagen I, MMP-1, and MMP-13.'?","No, this statement does not provide direct evidence for Ibuprofen preventing altitude sickness. It discusses the potential of Ibuprofen, along with other substances, in managing osteoarthritis (OA) by influencing certain biological pathways. Altitude sickness is a different condition, typically caused by rapid exposure to low air pressure and decreased oxygen levels, for which Ibuprofen might be used as a treatment but not a preventative measure based on this information alone." +19399624,Ibuprofen prevents osteoarthritis,62,"This study aims to determine the therapeutic effects of ibuprofen, diphenhydramine and aluminum magnesium simethicone (AlMgS) syrup on reducing oral aphthous ulcer pain.",False,"Is the triple 'Ibuprofen prevents osteoarthritis' supported by the sentence: 'This study aims to determine the therapeutic effects of ibuprofen, diphenhydramine and aluminum magnesium simethicone (AlMgS) syrup on reducing oral aphthous ulcer pain.'?","No, this statement does not provide support for the claim that ibuprofen prevents osteoarthritis, directly or indirectly. The study mentioned is focused on determining the therapeutic effects of ibuprofen, diphenhydramine, and aluminum magnesium simethicone syrup on reducing oral aphthous ulcer pain, not on osteoarthritis." +17687542,Ibuprofen prevents canker sore,63,"CONCLUSIONS: Considering the results of the study, reflexology was superior to Ibuprofen on reducing dysmenorrhea and its treatment effect continued even after discontinuing the intervention in the third cycle.",False,"Is the triple 'Ibuprofen prevents canker sore' supported by the sentence: 'CONCLUSIONS: Considering the results of the study, reflexology was superior to Ibuprofen on reducing dysmenorrhea and its treatment effect continued even after discontinuing the intervention in the third cycle.'?","No, it is not supported because the study focuses on reflexology's effect on dysmenorrhea, not on its effect on preventing canker sores." +15961024,Ibuprofen prevents Dysmenorrhea,64,CONCLUSION: We conclude that pain therapy with an almost peripherally acting drug such as ibuprofen can reduce osteoporosis-associated chronic pain better than a centrally acting pain medication such as tramadol.,True,Is the triple 'Ibuprofen prevents Dysmenorrhea' supported by the sentence: 'CONCLUSION: We conclude that pain therapy with an almost peripherally acting drug such as ibuprofen can reduce osteoporosis-associated chronic pain better than a centrally acting pain medication such as tramadol.'?,"Yes, it is indirectly supported, as it suggests ibuprofen's effectiveness in managing pain, which could extend to menstrual pain (dysmenorrhea). However, it does not directly mention dysmenorrhea." +13710734,Ibuprofen prevents Chronic pain,65,The objective of this study was to determine whether pretreatment with ibuprofen would prevent the onset or decrease the severity of headache that occurs after ECT.,True,Is the triple 'Ibuprofen prevents Chronic pain' supported by the sentence: 'The objective of this study was to determine whether pretreatment with ibuprofen would prevent the onset or decrease the severity of headache that occurs after ECT.'?,"Yes, it is indirectly supported. The statement suggests that ibuprofen may have a preventative effect on headache occurrence after ECT, which could be interpreted as a form of chronic pain (headache) prevention. However, it's important to note that chronic pain is a complex condition that typically refers to long-term pain, while a headache after ECT is likely a more acute condition." +10201705,Ibuprofen prevents Headache,66,The results of this study reveal that intake of ibuprofen can decrease muscle soreness induced after eccentric exercise but cannot assist in restoring muscle function.,False,Is the triple 'Ibuprofen prevents Headache' supported by the sentence: 'The results of this study reveal that intake of ibuprofen can decrease muscle soreness induced after eccentric exercise but cannot assist in restoring muscle function.'?,"No, it is not directly supported because it talks about muscle soreness after eccentric exercise, not headaches specifically, but it does suggest a general pain-relieving effect for Ibuprofen which could potentially extend to headaches as well, making it indirectly supportive." +10026105,Ibuprofen prevents Myalgia,67,The objective of our study was to determine the role of ibuprofen in protecting neutropenic rats from cardiopulmonary injury due to endotoxemia.,False,Is the triple 'Ibuprofen prevents Myalgia' supported by the sentence: 'The objective of our study was to determine the role of ibuprofen in protecting neutropenic rats from cardiopulmonary injury due to endotoxemia.'?,"No, it is not. The statement concerns a protective effect of ibuprofen on cardiopulmonary injury due to endotoxemia in neutropenic rats, not its effect on myalgia in humans." +9104502,Ibuprofen prevents injury,68,"To determine if prophylactic etodolac would significantly reduce postendodontic pain, when compared with ibuprofen or placebo, 36 patients consented to single blind oral administration of either 400 mg of etodolac, 600 mg of ibuprofen, or a placebo, before conventional one-appointment root canal therapy.",False,"Is the triple 'Ibuprofen prevents injury' supported by the sentence: 'To determine if prophylactic etodolac would significantly reduce postendodontic pain, when compared with ibuprofen or placebo, 36 patients consented to single blind oral administration of either 400 mg of etodolac, 600 mg of ibuprofen, or a placebo, before conventional one-appointment root canal therapy.'?","No, this statement does not provide direct support for the claim that Ibuprofen prevents injury. It discusses a study comparing ibuprofen, etodolac, and a placebo in reducing postendodontic pain, but it does not mention anything about injury prevention." +9022792,Ibuprofen prevents Pain,69,UNLABELLED: The aim of our study was to evaluate whether the prophylactic use of ibuprofen would reduce the incidence of significant patent ductus arteriosus (PDA) and to confirm the effectiveness of ibuprofen as rescue treatment in closing PDA.,False,Is the triple 'Ibuprofen prevents Pain' supported by the sentence: 'UNLABELLED: The aim of our study was to evaluate whether the prophylactic use of ibuprofen would reduce the incidence of significant patent ductus arteriosus (PDA) and to confirm the effectiveness of ibuprofen as rescue treatment in closing PDA.'?,"No, it is not directly supported because the statement does not mention pain prevention, but it can be indirectly related if patent ductus arteriosus (PDA) is associated with pain, which is not specified in the provided context." +8584177,Ibuprofen prevents patent ductus arteriosus,70,"Nonsteroidal anti-inflammatory drugs (NSAIDs) such as aspirin, indomethacin and ibuprofen are the most widely used drugs for pain, arthritis, cardiovascular diseases and, more recently, the prevention of colon cancer and Alzheimer disease.",True,"Is the triple 'Ibuprofen prevents patent ductus arteriosus' supported by the sentence: 'Nonsteroidal anti-inflammatory drugs (NSAIDs) such as aspirin, indomethacin and ibuprofen are the most widely used drugs for pain, arthritis, cardiovascular diseases and, more recently, the prevention of colon cancer and Alzheimer disease.'?","Yes, it is indirectly supported because ibuprofen is mentioned as a nonsteroidal anti-inflammatory drug (NSAID) that is used for various conditions, including cardiovascular diseases. However, it does not explicitly state that ibuprofen prevents patent ductus arteriosus." +7843138,Ibuprofen prevents Alzheimer disease,71,Aggravation of seizure-associated microvascular injuries by ibuprofen may involve multiple pathways.,False,Is the triple 'Ibuprofen prevents Alzheimer disease' supported by the sentence: 'Aggravation of seizure-associated microvascular injuries by ibuprofen may involve multiple pathways.'?,"No, it is not supported. The given sentence discusses how ibuprofen may exacerbate seizure-associated microvascular injuries, which is contrary to the claim that ibuprofen prevents Alzheimer's disease." +15342704,Ibuprofen exacerbates injury,72,"Use of paracetamol, ibuprofen or aspirin in pregnancy and risk of cerebral palsy in the child.",False,"Is the triple 'Ibuprofen exacerbates injury' supported by the sentence: 'Use of paracetamol, ibuprofen or aspirin in pregnancy and risk of cerebral palsy in the child.'?","No, it is not directly or indirectly supported. The given title discusses the use of pain relievers during pregnancy and their potential impact on cerebral palsy in the child. It does not mention anything about these pain relievers exacerbating injuries." +20007370,Ibuprofen predisposes cerebral palsy,73,"More than two cycles of ibuprofen was significantly associated with an increased risk for bronchopulmonary dysplasia (odds ratio [OR], 2.81; p = 0.03) and acute renal failure (OR, 3.81; p = 0.09).",False,"Is the triple 'Ibuprofen predisposes cerebral palsy' supported by the sentence: 'More than two cycles of ibuprofen was significantly associated with an increased risk for bronchopulmonary dysplasia (odds ratio [OR], 2.81; p = 0.03) and acute renal failure (OR, 3.81; p = 0.09).'?","No, it is not directly or indirectly supported, because there is no mention of cerebral palsy in the given sentence, it talks about bronchopulmonary dysplasia and acute renal failure in relation to Ibuprofen use in more than two cycles." +14332005,Ibuprofen predisposes bronchopulmonary dysplasia,74,OBJECTIVE: Non-steroidal anti-inflammatory drugs such as ibuprofen have a protective role on risk of Alzheimer's disease (AD).,False,Is the triple 'Ibuprofen predisposes bronchopulmonary dysplasia' supported by the sentence: 'OBJECTIVE: Non-steroidal anti-inflammatory drugs such as ibuprofen have a protective role on risk of Alzheimer's disease (AD).'?,"No, this statement does not support that ibuprofen predisposes to bronchopulmonary dysplasia (BPD). In fact, it suggests the opposite, that ibuprofen may have a protective role against Alzheimer's disease, which is a completely different medical condition. Bronchopulmonary dysplasia is a chronic lung disease in premature infants, while Alzheimer's disease is a neurodegenerative disorder primarily affecting older adults. Therefore, these two conditions are not directly related, and this statement does not provide any evidence for a link between ibuprofen and BPD." +14294004,Ibuprofen predisposes Alzheimer disease,75,"There seems to be a marked gradient of risk for acute kidney injury across agents, specifically for indomethacin, ibuprofen, and rofecoxib.",False,"Is the triple 'Ibuprofen predisposes Alzheimer disease' supported by the sentence: 'There seems to be a marked gradient of risk for acute kidney injury across agents, specifically for indomethacin, ibuprofen, and rofecoxib.'?","No, this statement does not support the claim that Ibuprofen predisposes Alzheimer's disease. It discusses the risk of acute kidney injury associated with different non-steroidal anti-inflammatory drugs (NSAIDs), including ibuprofen, but it does not mention or imply any connection with Alzheimer's disease." +14085648,Ibuprofen predisposes injury,76,"Significant heterogeneity was present for the NSAIDs; e.g., ibuprofen was associated with an increased overall fracture risk (OR = 2.09, 95% CI 2.00-2.18 for <20 DDD), while celecoxib was not (OR = 0.76, 95% CI 0.51-1.13 for <20 DDD, 2P < 0.01 for comparison).",True,"Is the triple 'Ibuprofen predisposes injury' supported by the sentence: 'Significant heterogeneity was present for the NSAIDs; e.g., ibuprofen was associated with an increased overall fracture risk (OR = 2.09, 95% CI 2.00-2.18 for <20 DDD), while celecoxib was not (OR = 0.76, 95% CI 0.51-1.13 for <20 DDD, 2P < 0.01 for comparison).'?","Yes, the statement suggests that ibuprofen use is associated with an increased overall fracture risk, which could imply a potential for increased injury risk. However, it does not directly state that ibuprofen predisposes injury." +12673407,Ibuprofen predisposes bone fracture,77,One should be more critical about ivabradine and low-dose digoxin in diastolic heart failure.,False,Is the triple 'Ibuprofen predisposes bone fracture' supported by the sentence: 'One should be more critical about ivabradine and low-dose digoxin in diastolic heart failure.'?,"No, it is not directly or indirectly related, as it talks about diastolic heart failure, not bone fractures, nor ibuprofen use." +17604344,Ivabradine related to diastolic heart failure,78,"Preclinical studies of ivabradine in animal models with induced AF demonstrated a reduction in HR, with no significant worsening of QT interval or mean arterial pressure.",False,"Is the triple 'Ivabradine related to diastolic heart failure' supported by the sentence: 'Preclinical studies of ivabradine in animal models with induced AF demonstrated a reduction in HR, with no significant worsening of QT interval or mean arterial pressure.'?","No, the sentence does not provide any information about the relationship between Ivabradine and diastolic heart failure, directly or indirectly. It discusses the effects of Ivabradine on heart rate, QT interval, and mean arterial pressure in animal models with induced AF, but it does not mention diastolic heart failure." +19228519,Ivabradine causes atrial fibrillation,79,"In this review, we summarize the current knowledge of the HCN4 channel and ivabradine, including the function of HCN4 in cardiac pacemaking, the mechanism of action of If inhibition by ivabradine, and the pharmacological and clinical effects of ivabradine in cardiac diseases as HF, coronary artery disease, and atrial fibrillation.",False,"Is the triple 'Ivabradine causes atrial fibrillation' supported by the sentence: 'In this review, we summarize the current knowledge of the HCN4 channel and ivabradine, including the function of HCN4 in cardiac pacemaking, the mechanism of action of If inhibition by ivabradine, and the pharmacological and clinical effects of ivabradine in cardiac diseases as HF, coronary artery disease, and atrial fibrillation.'?","No, the statement ""Ivabradine causes atrial fibrillation"" is not directly or indirectly supported by the provided sentence. The sentence discusses the relationship between Ivabradine and cardiac diseases including atrial fibrillation, but it does not confirm a causative role of Ivabradine in atrial fibrillation." +20784958,Ivabradine affects atrial fibrillation,80,Small studies have recently investigated the role of ivabradine in MS in sinus rhythm.,False,Is the triple 'Ivabradine affects atrial fibrillation' supported by the sentence: 'Small studies have recently investigated the role of ivabradine in MS in sinus rhythm.'?,"No, it is not directly supported because the sentence mentions sinus rhythm, not atrial fibrillation, although it does suggest a possible effect in a related condition (MS)." +20520107,Ivabradine affects mitral valve stenosis,81,The role of Ivabradine in Diastolic Heart Failure with preserved Ejection Fraction.,False,Is the triple 'Ivabradine affects mitral valve stenosis' supported by the sentence: 'The role of Ivabradine in Diastolic Heart Failure with preserved Ejection Fraction.'?,"No, this statement does not support a direct relationship between Ivabradine and mitral valve stenosis, as it discusses its role in diastolic heart failure with preserved ejection fraction, not its effects on specific heart conditions like mitral valve stenosis." +20004006,Ivabradine affects diastolic heart failure,82,"Other large trials are also underway to assess the effects of ivabradine on heart failure, acute coronary syndromes, CAD, and other cardiovascular disorders.",True,"Is the triple 'Ivabradine affects diastolic heart failure' supported by the sentence: 'Other large trials are also underway to assess the effects of ivabradine on heart failure, acute coronary syndromes, CAD, and other cardiovascular disorders.'?","Yes, it is indirectly supported because one of those 'large trials' could be investigating the effects of ivabradine on diastolic heart failure, which is a type of heart failure. However, this is an assumption as the specific trial is not mentioned in the given sentence." +15323309,Ivabradine affects cardiovascular disorder,83,"Other large trials are also underway to assess the effects of ivabradine on heart failure, acute coronary syndromes, CAD, and other cardiovascular disorders.",True,"Is the triple 'Ivabradine affects cardiovascular disorder' supported by the sentence: 'Other large trials are also underway to assess the effects of ivabradine on heart failure, acute coronary syndromes, CAD, and other cardiovascular disorders.'?","Yes, the statement suggests that there are ongoing studies investigating the effects of ivabradine on various cardiovascular disorders, including heart failure, acute coronary syndromes, coronary artery disease (CAD), and others. This implies that there is an interest in understanding the potential benefits of ivabradine in these areas, providing indirect support for the idea that ivabradine could affect these disorders. However, it's important to note that these studies have not yet reported their results, so any effects remain speculative at this point." +15323306,Ivabradine affects coronary artery disorder,84,Effective suppression of atrial fibrillation by ivabradine: Novel target for an established drug?,False,Is the triple 'Ivabradine affects coronary artery disorder' supported by the sentence: 'Effective suppression of atrial fibrillation by ivabradine: Novel target for an established drug?'?,"No, the given statement does not provide direct or indirect support for the claim that Ivabradine affects coronary artery disorder. The statement discusses Ivabradine's effectiveness in suppressing atrial fibrillation, which is a heart rhythm disorder, not a coronary artery disorder." +19514713,Ivabradine disrupts atrial fibrillation,85,[SIGNIFY study is a disappointment. Ivabradine cannot stop of the progression of coronary heart disease].,False,Is the triple 'Ivabradine disrupts atrial fibrillation' supported by the sentence: '[SIGNIFY study is a disappointment. Ivabradine cannot stop of the progression of coronary heart disease].'?,"No, it does not support that statement. The SIGNIFY trial was conducted to assess whether Ivabradine can prevent major cardiovascular events in patients with coronary artery disease (CAD) and normal heart rate, not to assess its effect on atrial fibrillation (AF). Therefore, this statement does not provide any information about Ivabradine's effect on AF, let alone its ability to disrupt it." +17909104,Ivabradine disrupts coronary artery disorder,86,RESULTS: Heart rate reduction and prevention of postoperative AF or tachyarrhythmia with combined therapy was more effective than with metoprolol or ivabradine alone during the immediate postoperative management of cardiac surgery patients.,True,Is the triple 'Ivabradine disrupts coronary artery disorder' supported by the sentence: 'RESULTS: Heart rate reduction and prevention of postoperative AF or tachyarrhythmia with combined therapy was more effective than with metoprolol or ivabradine alone during the immediate postoperative management of cardiac surgery patients.'?,"Yes, it is indirectly supported because the statement mentions that ivabradine, when used in combination with other therapies, is effective in reducing heart rate and preventing postoperative AF (atrial fibrillation) or tachyarrhythmia in cardiac surgery patients. However, it does not directly state that ivabradine disrupts coronary artery disorder, but it does suggest a potential benefit in cardiac surgery management." +17822394,Ivabradine prevents atrial fibrillation,87,"During exercise, ivabradine dose dependently and significantly reduced the exercise-induced tachycardia (-17, -21, and -32% at 0.25, 0.5, and 1 mg/kg, respectively, versus saline) without altering myocardial contractility nor mean ejection wall stress.",False,"Is the triple 'Ivabradine prevents atrial fibrillation' supported by the sentence: 'During exercise, ivabradine dose dependently and significantly reduced the exercise-induced tachycardia (-17, -21, and -32% at 0.25, 0.5, and 1 mg/kg, respectively, versus saline) without altering myocardial contractility nor mean ejection wall stress.'?",No. This statement does not provide any information about Ivabradine's effect on atrial fibrillation prevention. It discusses Ivabradine's effect on heart rate during exercise without altering myocardial contractility nor mean ejection wall stress in rats given different doses of Ivabradine versus a saline group. +10817471,Ivabradine prevents Tachycardia,88,Recent trials reported that risk of atrial fibrillation (AF) is increased in patients using ivabradine compared with controls.,False,Is the triple 'Ivabradine prevents Tachycardia' supported by the sentence: 'Recent trials reported that risk of atrial fibrillation (AF) is increased in patients using ivabradine compared with controls.'?,"No, it is not supported because an increased risk of atrial fibrillation (AF) is not indicative of prevention of tachycardia, but rather a potential cause for it." +19153602,Ivabradine predisposes atrial fibrillation,89,Randomized comparative study of cefixime versus cephalexin in acute bacterial exacerbations of chronic bronchitis.,False,Is the triple 'Ivabradine predisposes atrial fibrillation' supported by the sentence: 'Randomized comparative study of cefixime versus cephalexin in acute bacterial exacerbations of chronic bronchitis.'?,"No, that sentence does not provide any support for the claim that Ivabradine predisposes to atrial fibrillation, directly or indirectly. It is about a randomized comparative study of cefixime versus cephalexin in acute bacterial exacerbations of chronic bronchitis, with no mention of Ivabradine or atrial fibrillation." +15385004,Cefixime affects chronic bronchitis,90,Alterations of the pilQ gene in Neisseria gonorrhoeae are unlikely contributors to decreased susceptibility to ceftriaxone and cefixime in clinical gonococcal strains.,False,Is the triple 'Cefixime affects chronic bronchitis' supported by the sentence: 'Alterations of the pilQ gene in Neisseria gonorrhoeae are unlikely contributors to decreased susceptibility to ceftriaxone and cefixime in clinical gonococcal strains.'?,"No, it is not directly or indirectly supported. The given sentence discusses alterations of the pilQ gene in Neisseria gonorrhoeae affecting susceptibility to ceftriaxone and cefixime, which is not related to the treatment of chronic bronchitis with Cefixime." +15252860,Cefixime affects gonorrhea,91,"Because of the emergence of these bacteria, other antimicrobial agents, both old and new, have been advocated for treatment and prevention of otitis media; amoxicillin-clavulanate, cefuroxime axetil, and cefixime are the newer agents.",True,"Is the triple 'Cefixime affects gonorrhea' supported by the sentence: 'Because of the emergence of these bacteria, other antimicrobial agents, both old and new, have been advocated for treatment and prevention of otitis media; amoxicillin-clavulanate, cefuroxime axetil, and cefixime are the newer agents.'?","Yes, the statement does provide some level of support for the idea that Cefixime affects Gonorrhea, albeit indirectly. This is because Cefixime is listed as one of the newer antimicrobial agents used for treatment and prevention of otitis media, suggesting that it has antimicrobial properties. Gonorrhea is a type of bacterial infection, so it's plausible that Cefixime could also be used to treat it. However, this is an inference based on a general statement about Cefixime's antimicrobial properties, not a direct statement about its effect on Gonorrhea." +18811968,Cefixime prevents otitis media,92,Experimental comparison of protective characteristics of enalapril and trimetazidine in diabetic nephropathy.,False,Is the triple 'Cefixime prevents otitis media' supported by the sentence: 'Experimental comparison of protective characteristics of enalapril and trimetazidine in diabetic nephropathy.'?,"No, that statement does not provide support for the claim that Cefixime prevents otitis media, as it discusses experimental comparisons of enalapril and trimetazidine in diabetic nephropathy, not Cefixime's effectiveness in preventing otitis media." +17748395,Trimetazidine related to diabetic kidney disease,93,This study aimed to investigate the role of TMZ in diabetic nephropathy (DN) and its potential mechanisms.,True,Is the triple 'Trimetazidine related to diabetic kidney disease' supported by the sentence: 'This study aimed to investigate the role of TMZ in diabetic nephropathy (DN) and its potential mechanisms.'?,"Yes, it is indirectly supported, as Trimetazidine is being studied for its potential effects on Diabetic Nephropathy (DN), a complication associated with Diabetic Kidney Disease." +22426756,Trimetazidine affects diabetic kidney disease,94,Objective: This study investigates the effect of TMZ in sunitinib-induced cardiotoxicity in vivo and in vitro and molecular mechanisms.,False,Is the triple 'Trimetazidine affects diabetic kidney disease' supported by the sentence: 'Objective: This study investigates the effect of TMZ in sunitinib-induced cardiotoxicity in vivo and in vitro and molecular mechanisms.'?,"No, it is not directly nor indirectly supported. The mentioned sentence discusses Trimetazidine's (TMZ) role in sunitinib-induced cardiotoxicity, not in diabetic kidney disease." +21297588,Trimetazidine affects Cardiotoxicity,95,The role of trimetazidine in cardiovascular disease: beyond an anti-anginal agent.,True,Is the triple 'Trimetazidine affects Cardiotoxicity' supported by the sentence: 'The role of trimetazidine in cardiovascular disease: beyond an anti-anginal agent.'?,"Yes, it is indirectly supported. The title suggests that Trimetazidine has a broader role in cardiovascular disease beyond its known function as an anti-anginal agent, which could include effects on cardiotoxicity. However, it does not directly state that Trimetazidine affects cardiotoxicity." +19164679,Trimetazidine affects cardiovascular disorder,96,"Trimetazidine, 2.5 mg/kg/day i.p. for 3 days before doxorubicin administration plus 2.5 mg/kg/day p.o. for 10 weeks, was unable to prevent the development of doxorubicin-induced long-term cardiotoxicity.",False,"Is the triple 'Trimetazidine affects cardiovascular disorder' supported by the sentence: 'Trimetazidine, 2.5 mg/kg/day i.p. for 3 days before doxorubicin administration plus 2.5 mg/kg/day p.o. for 10 weeks, was unable to prevent the development of doxorubicin-induced long-term cardiotoxicity.'?","No, it is not directly supported because it states that Trimetazidine was unable to prevent long-term cardiotoxicity induced by doxorubicin, but it does not refute that Trimetazidine may have some effect on cardiovascular disorders in general." +18547788,Trimetazidine prevents Cardiotoxicity,97,Ranolazine was more effective than lidocaine in terminating persistent AF and in preventing the induction of AF.,False,Is the triple 'Trimetazidine prevents Cardiotoxicity' supported by the sentence: 'Ranolazine was more effective than lidocaine in terminating persistent AF and in preventing the induction of AF.'?,"No, it is not directly or indirectly supported, as Trimetazidine is not mentioned in this statement, nor does it involve any mechanism related to preventing cardiotoxicity." +13317799,Ranolazine causes atrial fibrillation,98,Role of Ranolazine in cardiovascular disease and diabetes: Exploring beyond angina.,False,Is the triple 'Ranolazine causes atrial fibrillation' supported by the sentence: 'Role of Ranolazine in cardiovascular disease and diabetes: Exploring beyond angina.'?,"No, it is not directly mentioned that ranolazine causes atrial fibrillation, nor is there any implicit indication, in this title alone, that it does so." +19314329,Ranolazine affects cardiovascular disorder,99,"Furthermore, the activated Akt/mTOR signaling pathway induced by AF was further activated by ranolazine.",True,"Is the triple 'Ranolazine affects cardiovascular disorder' supported by the sentence: 'Furthermore, the activated Akt/mTOR signaling pathway induced by AF was further activated by ranolazine.'?","Yes. The statement suggests that ranolazine activates a signaling pathway (Akt/mTOR) that is already activated in a certain cardiovascular condition (atrial fibrillation, or AF). This implies that ranolazine could have an impact on this condition, thus providing indirect support for the idea that ranolazine affects cardiovascular disorders." +19002641,Ranolazine affects atrial fibrillation,100,Recent evidence of beneficial effects of ranolazine (RAN) in type II diabetes motivates interest in the role of the late sodium current (INaL) in glucose-stimulated insulin secretion.,False,Is the triple 'Ranolazine affects atrial fibrillation' supported by the sentence: 'Recent evidence of beneficial effects of ranolazine (RAN) in type II diabetes motivates interest in the role of the late sodium current (INaL) in glucose-stimulated insulin secretion.'?,"No, this statement does not provide direct or indirect support for the idea that Ranolazine (RAN) affects atrial fibrillation (AFib). The sentence you provided discusses the potential role of RAN in glucose-stimulated insulin secretion in type II diabetes, which is not directly related to AFib, although there may be potential indirect links through general cardiovascular health. However, without further information connecting RAN, INaL, and AFib, we cannot definitively say that this statement supports the initial claim." +17881291,Ranolazine affects type 2 diabetes mellitus,101,Effect of ranolazine in preventing postoperative atrial fibrillation in patients undergoing coronary revascularization surgery.,False,Is the triple 'Ranolazine affects type 2 diabetes mellitus' supported by the sentence: 'Effect of ranolazine in preventing postoperative atrial fibrillation in patients undergoing coronary revascularization surgery.'?,"No, it is not directly related. The statement discusses the effect of Ranolazine on postoperative atrial fibrillation, not its impact on Type 2 Diabetes Mellitus." +16599546,Ranolazine affects atrial fibrillation,102,The anti-ischemic mechanism of action of ranolazine in stable ischemic heart disease.,False,Is the triple 'Ranolazine affects atrial fibrillation' supported by the sentence: 'The anti-ischemic mechanism of action of ranolazine in stable ischemic heart disease.'?,"No, it does not appear to be directly supported. The statement discusses ranolazine's use in stable ischemic heart disease, but it does not mention any effect on atrial fibrillation." +15199166,Ranolazine affects myocardial ischemia,103,Atrial-selective/predominant sodium channel blockers such as ranolazine effectively suppress AF in experimental models of AF involving canine isolated right atrial preparations at concentrations that produce little to no effect on ventricular electrophysiologic parameters.,True,Is the triple 'Ranolazine affects myocardial ischemia' supported by the sentence: 'Atrial-selective/predominant sodium channel blockers such as ranolazine effectively suppress AF in experimental models of AF involving canine isolated right atrial preparations at concentrations that produce little to no effect on ventricular electrophysiologic parameters.'?,"Yes, it could be interpreted as supporting the statement that ranolazine affects myocardial ischemia indirectly. The sentence suggests that ranolazine can suppress atrial fibrillation (AF) in canine models, which implies it may have a beneficial effect on cardiac function. However, it does not directly state that ranolazine improves myocardial ischemia, hence it's an indirect support." +13887428,Ranolazine disrupts atrial fibrillation,104,Ranolazine has been shown to decrease angina pectoris frequency and nitroglycerin consumption.,False,Is the triple 'Ranolazine disrupts atrial fibrillation' supported by the sentence: 'Ranolazine has been shown to decrease angina pectoris frequency and nitroglycerin consumption.'?,"No, it does not appear so. The provided statement discusses the benefits of Ranolazine in reducing angina pectoris frequency and nitroglycerin consumption, but it does not provide any direct or indirect evidence that Ranolazine disrupts atrial fibrillation." +17475563,Ranolazine prevents Angina pectoris,105,BACKGROUND: Ranolazine has been shown to reduce myocardial ischemia and symptom severity among selected patients with chronic angina.,True,Is the triple 'Ranolazine prevents Angina pectoris' supported by the sentence: 'BACKGROUND: Ranolazine has been shown to reduce myocardial ischemia and symptom severity among selected patients with chronic angina.'?,"Yes, it is. The statement suggests that ranolazine can reduce myocardial ischemia, a condition often associated with angina pectoris, which could potentially prevent angina symptoms in selected patients. However, it's important to note that this is an indirect relationship, as it doesn't directly state that ranolazine prevents angina, but rather that it can alleviate symptoms associated with it." +14751648,Ranolazine prevents myocardial ischemia,106,"Dominant frequency (DF) of AF was reduced by ranolazine in left atrium from 11.7 (10.7-20.5) Hz to 7.6 (2.9-8.8) Hz (P = 0.02, n = 6).",True,"Is the triple 'Ranolazine prevents myocardial ischemia' supported by the sentence: 'Dominant frequency (DF) of AF was reduced by ranolazine in left atrium from 11.7 (10.7-20.5) Hz to 7.6 (2.9-8.8) Hz (P = 0.02, n = 6).'?","Yes, it could be interpreted as indirect support. The sentence indicates that ranolazine reduces the dominant frequency of atrial fibrillation in the left atrium, which suggests a potential protective effect against myocardial ischemia, as atrial fibrillation can contribute to this condition. However, it's important to note that this doesn't directly prove that ranolazine prevents myocardial ischemia, as it doesn't show a cause-and-effect relationship between the two." +14280230,Ranolazine prevents atrial fibrillation,107,"After adjusting for potential sources of bias through propensity-score matched-pair analysis and conditional logistic regression, ranolazine was an independent predictor of preventing POAF (p < 0.0001).",True,"Is the triple 'Ranolazine prevents atrial fibrillation' supported by the sentence: 'After adjusting for potential sources of bias through propensity-score matched-pair analysis and conditional logistic regression, ranolazine was an independent predictor of preventing POAF (p < 0.0001).'?","Yes, the statement does provide some level of support for the idea that ranolazine may prevent atrial fibrillation (POAF in this context). It suggests that, after accounting for other factors that could influence the outcome, ranolazine was significantly associated with a lower risk of POAF. However, it's important to note that this does not definitively prove that ranolazine prevents atrial fibrillation, as correlation does not necessarily imply causation. Further research would be needed to confirm these findings and establish a causal relationship." +17988674,Ranolazine predisposes atrial fibrillation,108,Prednisolone furthers T-cell immunodeficiency and also reduces the intensity of autoimmune reactions in multiple sclerosis.,False,Is the triple 'Ranolazine predisposes atrial fibrillation' supported by the sentence: 'Prednisolone furthers T-cell immunodeficiency and also reduces the intensity of autoimmune reactions in multiple sclerosis.'?,"No, it is not directly related because it speaks about a different drug, prednisolone, and its effects on immunodeficiency and autoimmune reactions in multiple sclerosis, not about Ranolazine's potential to induce atrial fibrillation." +26862829,Prednisolone related to multiple sclerosis,109,[Pharmacokinetics of prednisolone in adrenal insufficiency ].,False,Is the triple 'Prednisolone related to multiple sclerosis' supported by the sentence: '[Pharmacokinetics of prednisolone in adrenal insufficiency ].'?,"No, the sentence does not provide any information about a relationship between Prednisolone and multiple sclerosis, directly or indirectly. It discusses the pharmacokinetics of Prednisolone in adrenal insufficiency, which is not relevant to multiple sclerosis." +26365803,Prednisolone related to adrenocortical insufficiency,110,It is concluded that VAP is effective therapy in AIL.,False,Is the triple 'Prednisolone related to adrenocortical insufficiency' supported by the sentence: 'It is concluded that VAP is effective therapy in AIL.'?,"No, it's not directly supported. The sentence ""It is concluded that VAP is effective therapy in AIL."" does not mention Prednisolone or adrenocortical insufficiency. Therefore, it doesn't provide any evidence for a relationship between Prednisolone and adrenocortical insufficiency." +26295217,Prednisolone related to angioimmunoblastic T-cell lymphoma,111,A thermographic assessment of three intra-articular prednisolone analogues given in rheumatoid synovitis.,False,Is the triple 'Prednisolone related to angioimmunoblastic T-cell lymphoma' supported by the sentence: 'A thermographic assessment of three intra-articular prednisolone analogues given in rheumatoid synovitis.'?,"No, it is not directly supported because it discusses prednisolone analogues in rheumatoid synovitis, not their relation with angioimmunoblastic T-cell lymphoma." +26194122,Prednisolone related to synovitis,112,The effect of small doses of prednisolone on the incidence of subcutaneous sarcomas induced by 3-methylcholanthrene in virgin female Swiss mice.,False,Is the triple 'Prednisolone related to synovitis' supported by the sentence: 'The effect of small doses of prednisolone on the incidence of subcutaneous sarcomas induced by 3-methylcholanthrene in virgin female Swiss mice.'?,"No, it is not directly supported because the focus of that statement is on subcutaneous sarcomas induced by 3-methylcholanthrene in mice, not on synovitis." +25959730,Prednisolone related to sarcoma,113,[Effects of chromocarb diethylamine and prednisolone in experimental uveitis induced by clove oil in rabbits].,False,Is the triple 'Prednisolone related to sarcoma' supported by the sentence: '[Effects of chromocarb diethylamine and prednisolone in experimental uveitis induced by clove oil in rabbits].'?,"No, the provided sentence does not support a direct or indirect relationship between Prednisolone and sarcoma. The title discusses experimental uveitis induced in rabbits using clove oil, with mentions of Chromocarb Diethylamine and Prednisolone, but it does not provide any information linking Prednisolone to sarcoma." +25621708,Prednisolone related to uveitis,114,[Effect of prednisolone and heparin on circulating T- and B-lymphocytes in glomerulonephritis and systemic lupus erythematosus].,False,Is the triple 'Prednisolone related to uveitis' supported by the sentence: '[Effect of prednisolone and heparin on circulating T- and B-lymphocytes in glomerulonephritis and systemic lupus erythematosus].'?,"No, it is not directly supported because the mentioned article talks about circulating T- and B-lymphocytes in glomerulonephritis and systemic lupus erythematosus, not about its relation with uveitis." +24523226,Prednisolone related to glomerulonephritis,115,[Effects of prednisolone on thyroidal-123I uptake in subacute thyroiditis].,False,Is the triple 'Prednisolone related to glomerulonephritis' supported by the sentence: '[Effects of prednisolone on thyroidal-123I uptake in subacute thyroiditis].'?,"No, that statement does not provide any direct or indirect support for a relationship between Prednisolone and glomerulonephritis. It discusses the effects of Prednisolone on thyroidal-123I uptake in subacute thyroiditis, not its relation to glomerulonephritis." +23496152,Prednisolone related to subacute thyroiditis,116,"Blood Eosinophil Depletion with Mepolizumab, Benralizumab and Prednisolone in Eosinophilic Asthma.",False,"Is the triple 'Prednisolone related to subacute thyroiditis' supported by the sentence: 'Blood Eosinophil Depletion with Mepolizumab, Benralizumab and Prednisolone in Eosinophilic Asthma.'?","No, it is not directly supported because the given sentence discusses blood eosinophil depletion with mepolizumab, benralizumab, and prednisolone in eosinophilic asthma, not in relation to subacute thyroiditis." +22194722,Prednisolone related to pulmonary eosinophilia,117,[Prednisolone and aspirin combination therapy in habitual abortion with autoantibodies].,False,Is the triple 'Prednisolone related to pulmonary eosinophilia' supported by the sentence: '[Prednisolone and aspirin combination therapy in habitual abortion with autoantibodies].'?,"No, the provided sentence does not directly support a relationship between Prednisolone and pulmonary eosinophilia. The sentence discusses a combination therapy of Prednisolone and aspirin in the context of habitual abortion with autoantibodies, not pulmonary eosinophilia." +21911849,Prednisolone related to habitual spontaneous abortion,118,"To illustrate this, we used an example of cost-effectiveness analysis for docetaxel in combination with prednisolone in metastatic hormone-refractory prostate cancer.",False,"Is the triple 'Prednisolone related to habitual spontaneous abortion' supported by the sentence: 'To illustrate this, we used an example of cost-effectiveness analysis for docetaxel in combination with prednisolone in metastatic hormone-refractory prostate cancer.'?",No. The mentioned sentence does not provide any support for a relationship between prednisolone and habitual spontaneous abortion. It discusses cost-effectiveness analysis for docetaxel in combination with prednisolone in metastatic hormone-refractory prostate cancer. +20512112,Prednisolone related to castration-resistant prostate carcinoma,119,Prednisolone is associated with a worse bone mineral density in primary adrenal insufficiency.,False,Is the triple 'Prednisolone related to castration-resistant prostate carcinoma' supported by the sentence: 'Prednisolone is associated with a worse bone mineral density in primary adrenal insufficiency.'?,"No, it is not directly supported. The association between Prednisolone use and worse bone mineral density in primary adrenal insufficiency does not necessarily imply a connection with castration-resistant prostate carcinoma. However, both topics involve Prednisolone, a type of steroid hormone, and bone health, so there may be some indirect relationship worth exploring in further research." +20312000,Prednisolone related to chronic primary adrenal insufficiency,120,CONCLUSIONS: Prednisolone was more effective in inducing response than itraconazole in acute-stage ABPA.,False,Is the triple 'Prednisolone related to chronic primary adrenal insufficiency' supported by the sentence: 'CONCLUSIONS: Prednisolone was more effective in inducing response than itraconazole in acute-stage ABPA.'?,"No, it is not directly supported as it discusses acute-stage Allergic Bronchopulmonary Aspergillosis (ABPA) treatment response, not Chronic Primary Adrenal Insufficiency." +20106181,Prednisolone related to allergic bronchopulmonary aspergillosis,121,"Purpose: The aim of this study was to compare asparaginase-related toxicities in two asparaginase preparations, namely native Escherichia coli L-asparaginase (L-ASP) and pegylated asparaginase (PEG-ASP) in combination with ifosfamide, methotrexate, etoposide, and prednisolone (IMEP) in natural killer (NK)/T-cell lymphoma (NTCL).",False,"Is the triple 'Prednisolone related to allergic bronchopulmonary aspergillosis' supported by the sentence: 'Purpose: The aim of this study was to compare asparaginase-related toxicities in two asparaginase preparations, namely native Escherichia coli L-asparaginase (L-ASP) and pegylated asparaginase (PEG-ASP) in combination with ifosfamide, methotrexate, etoposide, and prednisolone (IMEP) in natural killer (NK)/T-cell lymphoma (NTCL).'?","No, this sentence does not provide any information about a direct or indirect relationship between Prednisolone and allergic bronchopulmonary aspergillosis. It discusses a study comparing toxicities of two asparaginase preparations in combination with certain chemotherapy drugs, including prednisolone, in treating natural killer (NK)/T-cell lymphoma (NTCL)." +19750187,Prednisolone related to lymphoma,122,Prednisolone combined with adjunctive immunosuppression is not superior to prednisolone alone in terms of efficacy and safety in giant cell arteritis: meta-analysis.,False,Is the triple 'Prednisolone related to lymphoma' supported by the sentence: 'Prednisolone combined with adjunctive immunosuppression is not superior to prednisolone alone in terms of efficacy and safety in giant cell arteritis: meta-analysis.'?,"No, this statement does not provide support for a direct or indirect relationship between Prednisolone and lymphoma. The meta-analysis discussed here is focused on the efficacy and safety of Prednisolone, either alone or in combination with other immunosuppressants, in treating giant cell arteritis, not its relation to lymphoma." +17143213,Prednisolone related to temporal arteritis,123,CONCLUSION: GVP is well-tolerated regimen with high response rate and needs to be tested in late relapsed HL.,False,Is the triple 'Prednisolone related to temporal arteritis' supported by the sentence: 'CONCLUSION: GVP is well-tolerated regimen with high response rate and needs to be tested in late relapsed HL.'?,"No, it's not directly or indirectly supported because the sentence does not mention Prednisolone, temporal arteritis, or any relation between them. It discusses a treatment regimen (GVP) for late relapsed Hodgkin lymphoma (HL), its tolerance, response rate, but does not provide any connection with Prednisolone or temporal arteritis." +16983852,Prednisolone related to Hodgkins lymphoma,124,Early treatment with addition of low dose prednisolone to methotrexate improves therapeutic outcome in severe psoriatic arthritis.,False,Is the triple 'Prednisolone related to Hodgkins lymphoma' supported by the sentence: 'Early treatment with addition of low dose prednisolone to methotrexate improves therapeutic outcome in severe psoriatic arthritis.'?,"No, it is not directly supported because the sentence refers to a different medical condition (psoriatic arthritis) and does not mention Hodgkin's lymphoma. However, it does suggest that prednisolone can be beneficial in certain treatments, which could potentially be relevant in a broader medical context." +16960031,Prednisolone related to psoriatic arthritis,125,"CONCLUSION: Flu/Cy/ATG conditioning regimen, bone marrow as stem cell source and CSA, prednisolone and short methotrexate regimen were associated with better survival in AA.",True,"Is the triple 'Prednisolone related to psoriatic arthritis' supported by the sentence: 'CONCLUSION: Flu/Cy/ATG conditioning regimen, bone marrow as stem cell source and CSA, prednisolone and short methotrexate regimen were associated with better survival in AA.'?","Yes, the sentence does suggest a relationship between Prednisolone and better survival in a context of some medical condition (AA). However, it does not explicitly state that Prednisolone is used for treating psoriatic arthritis, nor does it imply a direct cause-effect relationship. Therefore, while there is some indirect support, it's not a direct confirmation of your statement." +16502712,Prednisolone related to aplastic anemia,126,Effect of addition of short course of prednisolone to gluten-free diet on mucosal epithelial cell regeneration and apoptosis in celiac disease: a pilot randomized controlled trial.,False,Is the triple 'Prednisolone related to aplastic anemia' supported by the sentence: 'Effect of addition of short course of prednisolone to gluten-free diet on mucosal epithelial cell regeneration and apoptosis in celiac disease: a pilot randomized controlled trial.'?,"No, this statement does not provide support for a direct or indirect relationship between Prednisolone and aplastic anemia. The study is focused on the effect of Prednisolone on mucosal epithelial cell regeneration and apoptosis in celiac disease, not on its relation to aplastic anemia." +16371065,Prednisolone related to celiac disease,127,Coadministration of cyclosporin a with prednisolone in acute interstitial pneumonia complicating polymyositis/dermatomyositis.,False,Is the triple 'Prednisolone related to celiac disease' supported by the sentence: 'Coadministration of cyclosporin a with prednisolone in acute interstitial pneumonia complicating polymyositis/dermatomyositis.'?,"No, that statement does not provide support for a direct or indirect relationship between Prednisolone and celiac disease. The statement mentions Prednisolone being used in conjunction with Cyclosporin A for treating acute interstitial pneumonia in polymyositis/dermatomyositis patients, but it does not mention or imply any connection to celiac disease." +16192798,Prednisolone related to dermatomyositis,128,"Efficacy of immunoglobulin plus prednisolone for prevention of coronary artery abnormalities in severe Kawasaki disease (RAISE study): a randomised, open-label, blinded-endpoints trial.",False,"Is the triple 'Prednisolone related to dermatomyositis' supported by the sentence: 'Efficacy of immunoglobulin plus prednisolone for prevention of coronary artery abnormalities in severe Kawasaki disease (RAISE study): a randomised, open-label, blinded-endpoints trial.'?","No, it is not directly or indirectly supported, as this study focuses on coronary artery abnormalities in Kawasaki disease, not on dermatomyositis, nor on any relationship with Prednisolone in that context." +16169223,Prednisolone related to mucocutaneous lymph node syndrome,129,"Response of vincristine, melphalan, cyclophosphamide and prednisolone in refractory multiple myeloma.",True,"Is the triple 'Prednisolone related to mucocutaneous lymph node syndrome' supported by the sentence: 'Response of vincristine, melphalan, cyclophosphamide and prednisolone in refractory multiple myeloma.'?","Yes, it is mentioned that prednisolone is used in combination with other drugs for treating refractory multiple myeloma, but it does not directly state that prednisolone is related to mucocutaneous lymph node syndrome in this context. However, prednisolone is a corticosteroid that can have various side effects, including immunosuppression, which could potentially be linked to mucocutaneous lymph node syndrome in a broader context. Nonetheless, based on this specific sentence, there is no direct support for a relationship between prednisolone and mucocutaneous lymph node syndrome." +16114172,Prednisolone related to plasma cell myeloma,130,Pyruvate kinase M2 and prednisolone resistance in acute lymphoblastic leukemia.,False,Is the triple 'Prednisolone related to plasma cell myeloma' supported by the sentence: 'Pyruvate kinase M2 and prednisolone resistance in acute lymphoblastic leukemia.'?,"No, it is not directly or indirectly supported because the sentence discusses pyruvate kinase M2 and prednisolone resistance in acute lymphoblastic leukemia, not multiple myeloma." +14564343,Prednisolone related to acute lymphoblastic leukemia,131,"Stimulation with prednisolone and TNFalpha reduced GDF-5 expression in OA and RA fibroblasts, whereas MTX and IL-1beta revealed minor or no relevant change.",False,"Is the triple 'Prednisolone related to acute lymphoblastic leukemia' supported by the sentence: 'Stimulation with prednisolone and TNFalpha reduced GDF-5 expression in OA and RA fibroblasts, whereas MTX and IL-1beta revealed minor or no relevant change.'?","No, this statement does not provide support for a direct or indirect relationship between Prednisolone and acute lymphoblastic leukemia. It discusses the effects of Prednisolone on GDF-5 expression in OA and RA fibroblasts, along with other substances, but it does not mention or imply any connection with acute lymphoblastic leukemia." +13988965,Prednisolone related to osteoarthritis,132,"A combination of rituximab plus chemotherapy, rituximab+cyclophosphamide+doxorubicin+vincristine+prednisolone (R-CHOP), has the highest efficacy ever described with any chemotherapy in DLBCL and FL.",False,"Is the triple 'Prednisolone related to osteoarthritis' supported by the sentence: 'A combination of rituximab plus chemotherapy, rituximab+cyclophosphamide+doxorubicin+vincristine+prednisolone (R-CHOP), has the highest efficacy ever described with any chemotherapy in DLBCL and FL.'?","No, the statement does not provide any direct or indirect support for a relationship between Prednisolone and osteoarthritis. The statement discusses the efficacy of a specific chemotherapy regimen, R-CHOP, in treating certain types of lymphoma, but it does not mention or imply any effect on osteoarthritis." +13151963,Prednisolone related to diffuse large B-cell lymphoma,133,"A combination of rituximab plus chemotherapy, rituximab+cyclophosphamide+doxorubicin+vincristine+prednisolone (R-CHOP), has the highest efficacy ever described with any chemotherapy in DLBCL and FL.",True,"Is the triple 'Prednisolone related to diffuse large B-cell lymphoma' supported by the sentence: 'A combination of rituximab plus chemotherapy, rituximab+cyclophosphamide+doxorubicin+vincristine+prednisolone (R-CHOP), has the highest efficacy ever described with any chemotherapy in DLBCL and FL.'?","Yes, in a way it is supported, as Prednisolone is part of the R-CHOP treatment regimen mentioned in the sentence, which is used for treating Diffuse Large B-Cell Lymphoma (DLBCL). However, it's important to note that this doesn't necessarily mean Prednisolone has a direct link to DLBCL, but rather it's part of a treatment regimen for this type of cancer." +13151962,Prednisolone related to follicular lymphoma,134,Weekly docetaxel and prednisolone versus prednisolone alone in androgen-independent prostate cancer: a randomized phase II study.,False,Is the triple 'Prednisolone related to follicular lymphoma' supported by the sentence: 'Weekly docetaxel and prednisolone versus prednisolone alone in androgen-independent prostate cancer: a randomized phase II study.'?,"No, that statement does not provide evidence for a direct or indirect link between Prednisolone and follicular lymphoma. It discusses Prednisolone in relation to androgen-independent prostate cancer, not follicular lymphoma." +12983495,Prednisolone related to prostate cancer,135,Prednisolone and azathioprine in membranous nephropathy: a 10-year follow-up study.,False,Is the triple 'Prednisolone related to prostate cancer' supported by the sentence: 'Prednisolone and azathioprine in membranous nephropathy: a 10-year follow-up study.'?,"No, that statement does not provide any direct or indirect support for a relationship between Prednisolone and prostate cancer. It discusses the use of Prednisolone and Azathioprine in membranous nephropathy, not their relation to prostate cancer." +12510603,Prednisolone related to membranous glomerulonephritis,136,"Taken together, the present study points to a strong inhibitory effect of liposomal PLP on tumor angiogenesis by reduction of the intratumoral production of the majority of pro-angiogenic factors studied and direct inhibition of endothelial cell proliferation, which is the result of high prolonged levels of prednisolone in the tumor by liposomal delivery.",False,"Is the triple 'Prednisolone related to membranous glomerulonephritis' supported by the sentence: 'Taken together, the present study points to a strong inhibitory effect of liposomal PLP on tumor angiogenesis by reduction of the intratumoral production of the majority of pro-angiogenic factors studied and direct inhibition of endothelial cell proliferation, which is the result of high prolonged levels of prednisolone in the tumor by liposomal delivery.'?",No. The statement does not provide any information about a direct or indirect relationship between Prednisolone and membranous glomerulonephritis. It discusses the inhibitory effect of liposomal PLP on tumor angiogenesis due to high prolonged levels of prednisolone in the tumor through liposomal delivery. +12496746,Prednisolone related to neoplasm,137,Prednisolone versus dexamethasone in croup: a randomised equivalence trial.,False,Is the triple 'Prednisolone related to neoplasm' supported by the sentence: 'Prednisolone versus dexamethasone in croup: a randomised equivalence trial.'?,"No, the provided sentence does not support a direct or indirect relationship between Prednisolone and neoplasm (cancer). The study mentioned is a randomized equivalence trial comparing Prednisolone and Dexamethasone in treating croup, a viral infection in children, with no mention of neoplasm." +12428137,Prednisolone related to croup,138,Use of ACTH and prednisolone in infantile spasms: experience from a developing country.,False,Is the triple 'Prednisolone related to croup' supported by the sentence: 'Use of ACTH and prednisolone in infantile spasms: experience from a developing country.'?,"No, it is not directly supported because that study is about using prednisolone for treating infantile spasms, not croup specifically. Croup is a respiratory disease that typically causes a harsh, barking cough, while infantile spasms refer to a type of epileptic seizure seen in infants. However, both conditions can be treated with steroids like prednisolone, so there is an indirect connection through the use of this drug for different medical conditions." +12061894,Prednisolone related to West syndrome,139,Bone mineral density in relation to efficacy and side effects of budesonide and prednisolone in Crohn's disease.,False,Is the triple 'Prednisolone related to West syndrome' supported by the sentence: 'Bone mineral density in relation to efficacy and side effects of budesonide and prednisolone in Crohn's disease.'?,"No, it is not directly or indirectly supported, as this passage discusses Prednisolone's use in Crohn's disease, not its relationship with West Syndrome." +11663099,Prednisolone related to Crohn disease,140,OBJECTIVE: To examine the safety and efficacy of methotrexate (MTX) plus low-dose prednisolone for induction of remission in non life- or organ-threatening courses and for remission maintenance in Churg-Strauss syndrome (CSS).,False,Is the triple 'Prednisolone related to Crohn disease' supported by the sentence: 'OBJECTIVE: To examine the safety and efficacy of methotrexate (MTX) plus low-dose prednisolone for induction of remission in non life- or organ-threatening courses and for remission maintenance in Churg-Strauss syndrome (CSS).'?,"No, this statement does not provide direct evidence that Prednisolone is related to Crohn's disease. It discusses the use of Methotrexate plus low-dose Prednisolone in Churg-Strauss syndrome, not Crohn's disease." +11638013,Prednisolone related to eosinophilic granulomatosis with polyangiitis,141,OBJECTIVE: To determine whether addition of low dose prednisolone to multidrug treatment can prevent reaction and nerve function impairment in leprosy.,True,Is the triple 'Prednisolone related to eosinophilic granulomatosis with polyangiitis' supported by the sentence: 'OBJECTIVE: To determine whether addition of low dose prednisolone to multidrug treatment can prevent reaction and nerve function impairment in leprosy.'?,"Yes, it is indirectly supported, as both Prednisolone and Eosinophilic Granulomatosis with Polyangiitis (EGPA) involve inflammation and immune response, although they are different medical conditions. Prednisolone is a corticosteroid often used in treating inflammatory diseases, including some forms of vasculitis like EGPA, due to its anti-inflammatory properties. The mentioned sentence implies that Prednisolone can be used in preventing inflammation in leprosy, which aligns with its known use in managing inflammation associated with EGPA, albeit in a different context." +11213963,Prednisolone related to leprosy,142,A double-blind randomized controlled trial of infliximab associated with prednisolone in acute alcoholic hepatitis.,False,Is the triple 'Prednisolone related to leprosy' supported by the sentence: 'A double-blind randomized controlled trial of infliximab associated with prednisolone in acute alcoholic hepatitis.'?,"No, the sentence does not provide support for a direct relationship between Prednisolone and leprosy, as it discusses a study on a different medical condition (acute alcoholic hepatitis) with a different drug (infliximab)." +11179224,Prednisolone related to alcoholic hepatitis,143,EULAR randomised controlled trial of pulse cyclophosphamide and methylprednisolone versus continuous cyclophosphamide and prednisolone followed by azathioprine and prednisolone in lupus nephritis.,False,Is the triple 'Prednisolone related to alcoholic hepatitis' supported by the sentence: 'EULAR randomised controlled trial of pulse cyclophosphamide and methylprednisolone versus continuous cyclophosphamide and prednisolone followed by azathioprine and prednisolone in lupus nephritis.'?,"No, this sentence does not provide support for a direct or indirect relationship between Prednisolone and alcoholic hepatitis. The sentence discusses a European League Against Rheumatism (EULAR) randomized controlled trial involving lupus nephritis, not alcoholic hepatitis, and it mentions Prednisolone in combination with other treatments, not as a standalone treatment for alcoholic hepatitis." +11142916,Prednisolone related to lupus nephritis,144,OBJECTIVE: To investigate the safety and efficacy of leflunomide plus low-dose prednisolone for the maintenance of remission in Wegener's granulomatosis (WG).,True,Is the triple 'Prednisolone related to lupus nephritis' supported by the sentence: 'OBJECTIVE: To investigate the safety and efficacy of leflunomide plus low-dose prednisolone for the maintenance of remission in Wegener's granulomatosis (WG).'?,"Yes, in a way it is supported, because it mentions prednisolone being used in a treatment context for a disease that is similar in some aspects to lupus nephritis, namely Wegener's granulomatosis, which is a type of vasculitis. However, it does not directly prove a relationship between prednisolone and lupus nephritis, but rather suggests its use in a broader context of autoimmune diseases." +11037266,Prednisolone related to granulomatosis with polyangiitis,145,"Treatment with combined therapy of adriamycin, vincristine and prednisolone produced a remission in the leukaemia with complete resolution of the breast mass.",False,"Is the triple 'Prednisolone related to granulomatosis with polyangiitis' supported by the sentence: 'Treatment with combined therapy of adriamycin, vincristine and prednisolone produced a remission in the leukaemia with complete resolution of the breast mass.'?","No, this statement does not provide evidence that prednisolone is related to granulomatosis with polyangiitis. The sentence discusses the treatment of leukaemia and a breast mass, not granulomatosis with polyangiitis." +11013570,Prednisolone related to leukemia,146,RESULTS: The average initial dose of prednisolone in polymyalgia rheumatica was 35 mg; 51 of 62 patients were given a starting dose exceeding 15 mg.,False,Is the triple 'Prednisolone related to leukemia' supported by the sentence: 'RESULTS: The average initial dose of prednisolone in polymyalgia rheumatica was 35 mg; 51 of 62 patients were given a starting dose exceeding 15 mg.'?,"No, this statement does not provide any information about a relationship between Prednisolone and leukemia, it is about dosage in polymyalgia rheumatica treatment." +10949449,Prednisolone related to polymyalgia rheumatica,147,[Trans-utero-tubal administration of prednisolone in sterility caused by obstruction of the tubes].,False,Is the triple 'Prednisolone related to polymyalgia rheumatica' supported by the sentence: '[Trans-utero-tubal administration of prednisolone in sterility caused by obstruction of the tubes].'?,"No, the statement you provided does not seem to provide any direct or indirect support for a relationship between Prednisolone and polymyalgia rheumatica. It discusses the use of Prednisolone in a specific medical context (treating sterility caused by tubal obstruction), but it does not mention or imply any connection with polymyalgia rheumatica, which is a specific inflammatory disease." +10748640,Prednisolone related to infertility disorder,148,[On experiences with a combination preparation from prednisolone and an antihistaminic in dermatology especially in endogenous eczema].,False,Is the triple 'Prednisolone related to infertility disorder' supported by the sentence: '[On experiences with a combination preparation from prednisolone and an antihistaminic in dermatology especially in endogenous eczema].'?,"No, this statement does not provide any information suggesting a relationship between Prednisolone and infertility disorders, directly or indirectly. It discusses its use in dermatology, specifically in endogenous eczema, in conjunction with an antihistaminic, but it does not mention fertility or reproductive health." +10744705,"Prednisolone related to dermatitis, atopic",149,[USE OF PREDNISOLONE IN SOME GRAVE FORMS OF PATHOLOGY OF THE PREMATURE INFANT].,False,"Is the triple 'Prednisolone related to dermatitis, atopic' supported by the sentence: '[USE OF PREDNISOLONE IN SOME GRAVE FORMS OF PATHOLOGY OF THE PREMATURE INFANT].'?","No, it is not directly supported because it refers specifically to premature infants with grave forms of pathology. It does not specifically address atopic dermatitis in any population." +10736101,Prednisolone related to Graves disease,150,[EFFECT OF PREDNISOLONE ON THE CARDIAC ACTIVITY IN LIVER AND KIDNEY DISEASES AND IN RHEUMATISM].,False,Is the triple 'Prednisolone related to Graves disease' supported by the sentence: '[EFFECT OF PREDNISOLONE ON THE CARDIAC ACTIVITY IN LIVER AND KIDNEY DISEASES AND IN RHEUMATISM].'?,"No, it is not directly supported, as the given statement does not mention any connection between Prednisolone, cardiac activity, and Graves' disease, which is an autoimmune disorder that affects the thyroid gland, potentially causing hyperthyroidism, among other symptoms." +10735679,Prednisolone related to kidney disorder,151,"In this limited pilot study, we compared the effect on clinical outcome of treating Pseudomonas keratitis in guinea pigs with prednisolone (a corticosteroid), flurbiprofen (a cyclo-oxygenase inhibitor), nordihydroguaiaretic acid (a lipoxygenase inhibitor), and a leukotriene antagonist, SKF104353 [R-(R*, S*)]-beta-[(2-carboxyethyl) thio-alpha-hydroxy-2-(8-phenyloctyl) benzenepropanoic acid, zinc salt].",False,"Is the triple 'Prednisolone related to kidney disorder' supported by the sentence: 'In this limited pilot study, we compared the effect on clinical outcome of treating Pseudomonas keratitis in guinea pigs with prednisolone (a corticosteroid), flurbiprofen (a cyclo-oxygenase inhibitor), nordihydroguaiaretic acid (a lipoxygenase inhibitor), and a leukotriene antagonist, SKF104353 [R-(R*, S*)]-beta-[(2-carboxyethyl) thio-alpha-hydroxy-2-(8-phenyloctyl) benzenepropanoic acid, zinc salt].'?","No, it is not directly nor indirectly supported by that sentence as it does not mention nor imply any connection between Prednisolone and kidney disorders in any way." +10715297,Prednisolone related to keratitis,152,URINARY EXCRETION OF PREDNISOLONE AFTER INTRARECTAL THERAPY IN ULCERATIVE COLITIS.,False,Is the triple 'Prednisolone related to keratitis' supported by the sentence: 'URINARY EXCRETION OF PREDNISOLONE AFTER INTRARECTAL THERAPY IN ULCERATIVE COLITIS.'?,"No, this statement does not provide support for a direct or indirect relationship between Prednisolone and keratitis, as it discusses urinary excretion of Prednisolone in relation to ulcerative colitis therapy, not its effects on the eye or cornea specifically. Keratitis is an inflammation of the cornea, which is not mentioned in this statement." +10703266,Prednisolone related to ulcerative colitis,153,"Male rats treated with either budesonide, prednisolone, or triamcinolone acetonide in drinking water for up to 104 weeks developed slightly increased incidences of basophilic foci, and significantly increased incidences of combined hepatocellular adenomas/carcinomas as compared to controls.",True,"Is the triple 'Prednisolone related to ulcerative colitis' supported by the sentence: 'Male rats treated with either budesonide, prednisolone, or triamcinolone acetonide in drinking water for up to 104 weeks developed slightly increased incidences of basophilic foci, and significantly increased incidences of combined hepatocellular adenomas/carcinomas as compared to controls.'?","Yes, it is indirectly supported because all three drugs (including prednisolone) were associated with increased incidences of hepatocellular adenomas/carcinomas, but it does not specifically link prednisolone to ulcerative colitis." +10687782,Prednisolone related to hepatocellular carcinoma,154,[On the use of prednisolone in hemolytic anemia of the newborn caused by fetomaternal Rh-factor incompatibility].,False,Is the triple 'Prednisolone related to hepatocellular carcinoma' supported by the sentence: '[On the use of prednisolone in hemolytic anemia of the newborn caused by fetomaternal Rh-factor incompatibility].'?,"No, there is no direct mention or indication in this sentence that Prednisolone is related to hepatocellular carcinoma. This statement discusses the use of Prednisolone in hemolytic anemia caused by fetomaternal Rh-factor incompatibility, but it does not make any connection with hepatocellular carcinoma." +10623724,Prednisolone related to hemolytic anemia,155,Long-term use of prednisone and prednisolone in juvenile rheumatoid arthritis; a report of fifteen cases.,False,Is the triple 'Prednisolone related to hemolytic anemia' supported by the sentence: 'Long-term use of prednisone and prednisolone in juvenile rheumatoid arthritis; a report of fifteen cases.'?,"No, that sentence does not provide direct evidence that Prednisolone is related to hemolytic anemia. It mentions long-term use in juvenile rheumatoid arthritis, but it does not mention any side effects such as hemolytic anemia." +10576837,Prednisolone related to juvenile idiopathic arthritis,156,[Effect of prednisolone and human albumin on protein excretion in nephrotic syndrome].,False,Is the triple 'Prednisolone related to juvenile idiopathic arthritis' supported by the sentence: '[Effect of prednisolone and human albumin on protein excretion in nephrotic syndrome].'?,"No, that statement does not provide any direct or indirect support for a connection between Prednisolone and juvenile idiopathic arthritis. The title you provided discusses the effect of Prednisolone on protein excretion in nephrotic syndrome, which is a different medical condition." +10565620,Prednisolone related to nephrotic syndrome,157,[Therapeutic results of metacortandralone or prednisolone in allergy].,False,Is the triple 'Prednisolone related to nephrotic syndrome' supported by the sentence: '[Therapeutic results of metacortandralone or prednisolone in allergy].'?,"No, it is not directly or indirectly supported, as there is no mention nor reference to nephrotic syndrome in that given statement about therapeutic results in allergy with Metacortandralone or Prednisolone." +10531966,Prednisolone related to allergic disease,158,Primary resistance to vincristine (Vcr) and prednisolone in untreated AML was observed as well as 'acquired' resistance to several other antileukemic drugs.,False,Is the triple 'Prednisolone related to allergic disease' supported by the sentence: 'Primary resistance to vincristine (Vcr) and prednisolone in untreated AML was observed as well as 'acquired' resistance to several other antileukemic drugs.'?,"No, it is not directly supported because there is no mention of an allergy in this context, but it does not rule out an indirect relationship through its use in treatment of acute myeloid leukemia (AML)." +10527508,Prednisolone related to acute myeloid leukemia,159,"REPORT of the Committee on New Drugs of the Research Council of the American Academy of Allergy, 1955-56; studies on prednisone and prednisolone in ragweed pollinosis.",False,"Is the triple 'Prednisolone related to acute myeloid leukemia' supported by the sentence: 'REPORT of the Committee on New Drugs of the Research Council of the American Academy of Allergy, 1955-56; studies on prednisone and prednisolone in ragweed pollinosis.'?","No, that statement does not provide any information about a relationship between Prednisolone and acute myeloid leukemia, directly or indirectly. It merely mentions studies on Prednisone and Prednisolone in ragweed pollinosis." +10503828,Prednisolone related to seasonal allergic rhinitis,160,Effects of prednisone and prednisolone in ocular inflammation.,False,Is the triple 'Prednisolone related to seasonal allergic rhinitis' supported by the sentence: 'Effects of prednisone and prednisolone in ocular inflammation.'?,"No, that statement does not provide direct or indirect support for a relationship between Prednisolone and seasonal allergic rhinitis. It discusses the effects of Prednisolone in ocular inflammation, not in relation to seasonal allergies." +10496403,Prednisolone related to Inflammation,161,"Prednisolone scored better than prednisone in the categories of texture, taste, and aftertaste (p < 0.05); there was no statistical difference in smell.",False,"Is the triple 'Prednisolone related to Inflammation' supported by the sentence: 'Prednisolone scored better than prednisone in the categories of texture, taste, and aftertaste (p < 0.05); there was no statistical difference in smell.'?","No, this statement does not provide any information about a relationship between Prednisolone and inflammation, either directly or indirectly. It is a comparison of sensory attributes between Prednisolone and Prednisone, with no mention of inflammation." +10118116,Prednisolone related to Prednisone,162,Plasma prednisolone levels after administration of prednisolone-21-phosphate as a retention enema in colitis.,True,Is the triple 'Prednisolone related to Prednisone' supported by the sentence: 'Plasma prednisolone levels after administration of prednisolone-21-phosphate as a retention enema in colitis.'?,"Yes, there is an indirect relationship between Prednisolone and Prednisone based on your provided sentence. Both drugs belong to a class called glucocorticoids, which have anti-inflammatory and immunosuppressive effects. The sentence you provided indicates that Prednisolone is administered as a retention enema in colitis, which supports its classification as a glucocorticoid drug like Prednisone, although they have different chemical forms (Prednisolone is a metabolite of Prednisone)." +9924521,Prednisolone related to colitis,163,Mizoribine as an effective combined maintenance therapy with prednisolone in child-onset systemic lupus erythematosus.,True,Is the triple 'Prednisolone related to colitis' supported by the sentence: 'Mizoribine as an effective combined maintenance therapy with prednisolone in child-onset systemic lupus erythematosus.'?,"Yes, it is indirectly supported because it mentions prednisolone being used in a treatment context, but it does not directly state a relationship between prednisolone and colitis." +9437304,Prednisolone related to systemic lupus erythematosus,164,Controlled prospective trial of prednisolone and cytotoxics in progressive IgA nephropathy.,False,Is the triple 'Prednisolone related to systemic lupus erythematosus' supported by the sentence: 'Controlled prospective trial of prednisolone and cytotoxics in progressive IgA nephropathy.'?,"No, it is not directly supported because IgA nephropathy is a specific kidney disease, not systemic lupus erythematosus (SLE). However, since Prednisolone is often used as a treatment for autoimmune diseases, including SLE, one could argue that there is an indirect connection in terms of Prednisolone's use in autoimmune disease management. But specifically linking Prednisolone to SLE through this sentence is not accurate." +9282196,Prednisolone related to IgA glomerulonephritis,165,"We propose that FE(NO) is associated with eosinophilic inflammation in children with difficult asthma, following prednisolone, and may help in identifying patients in whom persistent symptoms are associated with airway eosinophilia.",True,"Is the triple 'Prednisolone related to IgA glomerulonephritis' supported by the sentence: 'We propose that FE(NO) is associated with eosinophilic inflammation in children with difficult asthma, following prednisolone, and may help in identifying patients in whom persistent symptoms are associated with airway eosinophilia.'?","Yes, it could be interpreted as indirectly supportive. The sentence mentions a relationship between prednisolone use in children with difficult asthma, eosinophilic inflammation, and airway eosinophilia. While it doesn't directly mention IgA glomerulonephritis, eosinophilic inflammation has been linked to certain kidney diseases, including IgA nephropathy, which is a type of glomerulonephritis. However, this is a complex area with many variables, so further research would be needed to establish a direct link." +9222009,Prednisolone related to hypereosinophilic syndrome,166,"Liposomal daunorubicin (DaunoXome) in combination with cyclophosphamide, vincristine and prednisolone (COP-X) as salvage therapy in poor-prognosis non-Hodgkins lymphoma.",False,"Is the triple 'Prednisolone related to hypereosinophilic syndrome' supported by the sentence: 'Liposomal daunorubicin (DaunoXome) in combination with cyclophosphamide, vincristine and prednisolone (COP-X) as salvage therapy in poor-prognosis non-Hodgkins lymphoma.'?","No, this statement does not provide evidence that Prednisolone is directly or indirectly related to Hypereosinophilic Syndrome. It mentions Prednisolone in combination with other drugs for non-Hodgkins lymphoma treatment, but it does not link it with Hypereosinophilic Syndrome." +9216084,Prednisolone related to non-Hodgkin lymphoma,167,Prednisolone in Duchenne muscular dystrophy.,False,Is the triple 'Prednisolone related to non-Hodgkin lymphoma' supported by the sentence: 'Prednisolone in Duchenne muscular dystrophy.'?,"No, that statement does not provide evidence of a relationship between Prednisolone and non-Hodgkin lymphoma, directly or indirectly. It simply mentions Prednisolone being used in Duchenne muscular dystrophy." +9208405,Prednisolone related to Duchenne muscular dystrophy,168,Intravenous prednisolone in chronic bronchial asthma.,False,Is the triple 'Prednisolone related to Duchenne muscular dystrophy' supported by the sentence: 'Intravenous prednisolone in chronic bronchial asthma.'?,"No, there is no direct or indirect mention of a relationship between Prednisolone and Duchenne Muscular Dystrophy in that sentence about chronic bronchial asthma treatment with Prednisolone." +8405261,Prednisolone related to asthma,169,Reversibility with prednisolone is rarely seen in COPD.,True,Is the triple 'Prednisolone related to asthma' supported by the sentence: 'Reversibility with prednisolone is rarely seen in COPD.'?,"Yes, it is indirectly supported because it suggests that Prednisolone has an effect on obstructive lung diseases, but it may not be effective in COPD, which could imply that it has a role in other diseases like Asthma where it might show more reversibility." +7844202,Prednisolone related to chronic obstructive pulmonary disease,170,"In spite of the fact that prednisolone-based treatment of pemphigus patients has proved to be effective in controlling the disease, some undesirable effects associated with this form of treatment have prompted investigation into other therapeutic approaches.",False,"Is the triple 'Prednisolone related to chronic obstructive pulmonary disease' supported by the sentence: 'In spite of the fact that prednisolone-based treatment of pemphigus patients has proved to be effective in controlling the disease, some undesirable effects associated with this form of treatment have prompted investigation into other therapeutic approaches.'?","No, this statement does not provide evidence for a direct or indirect relationship between Prednisolone and Chronic Obstructive Pulmonary Disease (COPD). The statement discusses the use of Prednisolone in treating pemphigus patients, focusing on its effectiveness and associated undesirable effects, but it does not mention COPD or any other respiratory diseases." +7323744,Prednisolone related to pemphigus,171,One reason for the good clinical effects of prednisolone in RA could be a down-regulation of adhesion and phagocytosis receptors on monocytes.,False,Is the triple 'Prednisolone related to pemphigus' supported by the sentence: 'One reason for the good clinical effects of prednisolone in RA could be a down-regulation of adhesion and phagocytosis receptors on monocytes.'?,"No, it is not directly supported because it refers specifically to rheumatoid arthritis (RA) rather than pemphigus, which is a different autoimmune disease. However, it does suggest a possible mechanism through which corticosteroids like prednisolone can have immunosuppressive effects, which could potentially be relevant in treating pemphigus as well." +7262473,Prednisolone related to rheumatoid arthritis,172,OBJECTIVE: To appraise the adjunctive role of prednisolone (PN) in pulmonary tuberculosis (PTB) with toxic reactions.,False,Is the triple 'Prednisolone related to rheumatoid arthritis' supported by the sentence: 'OBJECTIVE: To appraise the adjunctive role of prednisolone (PN) in pulmonary tuberculosis (PTB) with toxic reactions.'?,"No, this statement does not provide support for a direct or indirect relationship between Prednisolone and rheumatoid arthritis. The statement discusses the adjunctive role of Prednisolone in pulmonary tuberculosis, not in rheumatoid arthritis." +7206314,Prednisolone related to pulmonary tuberculosis,173,"A significant reduction of survival was found with the presence of permanent visual loss vs absence (p = 0.04), in patients who required more than 10 mg/d of glucocorticoid (p < 0.001) at 6 months treatment and in patients treated with prednisone (vs prednisolone) (p < 0.01).",False,"Is the triple 'Prednisolone related to pulmonary tuberculosis' supported by the sentence: 'A significant reduction of survival was found with the presence of permanent visual loss vs absence (p = 0.04), in patients who required more than 10 mg/d of glucocorticoid (p < 0.001) at 6 months treatment and in patients treated with prednisone (vs prednisolone) (p < 0.01).'?","No, this sentence does not provide direct evidence that Prednisolone is related to pulmonary tuberculosis. It suggests a correlation between visual loss, higher doses of glucocorticoids, and treatment with prednisone (not prednisolone), but it does not mention or imply a connection with pulmonary tuberculosis." +8856354,Prednisolone related to Prednisone,174,"Fourteen patients developed hyperglycemia during induction therapy of acute lymphoblastic leukemia with L-asparaginase, prednisolone, vincristine and daunorubicin.",True,"Is the triple 'Prednisolone related to Prednisone' supported by the sentence: 'Fourteen patients developed hyperglycemia during induction therapy of acute lymphoblastic leukemia with L-asparaginase, prednisolone, vincristine and daunorubicin.'?","Yes, it is indirectly supported because prednisolone is mentioned in the same treatment regimen as L-asparaginase, vincristine, and daunorubicin, which suggests a relationship between prednisolone and other treatments for acute lymphoblastic leukemia, such as prednisone, which is a glucocorticoid like prednisolone, used in similar treatment regimens for this disease." +26879702,Prednisolone has part acute lymphoblastic leukemia,175,A 66-year-old man was treated for IgD (lambda) multiple myeloma with 2mg/day melphalan and 20mg/day prednisolone.,False,Is the triple 'Prednisolone has part acute lymphoblastic leukemia' supported by the sentence: 'A 66-year-old man was treated for IgD (lambda) multiple myeloma with 2mg/day melphalan and 20mg/day prednisolone.'?,"No, this statement does not provide direct or indirect support for the claim that Prednisolone has a role in treating acute lymphoblastic leukemia (ALL). The sentence mentions a case of IgD (lambda) multiple myeloma being treated with Prednisolone, but it does not mention ALL or any form of leukemia." +26670577,Prednisolone has part plasma cell myeloma,176,"Moreover, after recent findings regarding the presence of endogenous prednisolone in the urine of more popular breeds, particular attention was given to analysis of the presence of prednisolone and prednisone, as well.",True,"Is the triple 'Prednisolone has part plasma cell myeloma' supported by the sentence: 'Moreover, after recent findings regarding the presence of endogenous prednisolone in the urine of more popular breeds, particular attention was given to analysis of the presence of prednisolone and prednisone, as well.'?","Yes, it is indirectly supported. The mention of endogenous prednisolone in urine suggests that prednisolone is present in these breeds naturally, which could potentially have an impact on plasma cell myeloma, a condition that involves abnormal plasma cells in bone marrow. However, this is a very indirect connection and would require further research to confirm any relationship between prednisolone and plasma cell myeloma in these breeds." +18935086,Prednisolone coexists with Prednisone,177,"Of 10 mg of prednisone given orally to 5 normal subjects, 69+/-5% was absorbed and converted to peripheral plasma prednisolone within 8 h.",True,"Is the triple 'Prednisolone coexists with Prednisone' supported by the sentence: 'Of 10 mg of prednisone given orally to 5 normal subjects, 69+/-5% was absorbed and converted to peripheral plasma prednisolone within 8 h.'?","Yes, it is indirectly supported because it suggests that Prednisolone is a metabolite of Prednisone, meaning they can exist together in the body after oral administration of Prednisone." +9296680,Prednisolone derives from Prednisone,178,"As in humans, prednisolone was partly converted to prednisone in the rabbit.",False,"Is the triple 'Prednisolone derives from Prednisone' supported by the sentence: 'As in humans, prednisolone was partly converted to prednisone in the rabbit.'?","No, it is not directly supported because it suggests that prednisone is converted to prednisolone, not the other way around." +26415442,Prednisolone derives from Prednisone,179,"Given the close resemblance of the ring A structure of prednisolone and prednisone on the one hand, and of androstadienedione on the other, the transformation of cortisol and cortisone into prednisolone and prednisone in cattle faeces was evaluated.",True,"Is the triple 'Prednisolone derives from Prednisone' supported by the sentence: 'Given the close resemblance of the ring A structure of prednisolone and prednisone on the one hand, and of androstadienedione on the other, the transformation of cortisol and cortisone into prednisolone and prednisone in cattle faeces was evaluated.'?","Yes, it is indirectly supported because prednisolone and prednisone both share a similar structure with cortisol, cortisone, and androstadienedione, as mentioned in the provided sentence. However, it does not explicitly state that prednisolone derives from prednisone, but rather they share a common transformation process in cattle feces with cortisol, cortisone, and androstadienedione." +14808035,Prednisolone physically interacts with Prednisone,180,The data indicate that prednisone is extensively metabolized to prednisolone before it clears the splanchnic circulation and the formation prednisone by oxidation of the 11-hydorxyl group of prednisolone appears to occur mainly in peripheral tissues.,True,Is the triple 'Prednisolone physically interacts with Prednisone' supported by the sentence: 'The data indicate that prednisone is extensively metabolized to prednisolone before it clears the splanchnic circulation and the formation prednisone by oxidation of the 11-hydorxyl group of prednisolone appears to occur mainly in peripheral tissues.'?,"Yes, the statement suggests an indirect interaction between prednisolone and prednisone. According to the text, prednisone is metabolized into prednisolone in the splanchnic circulation, which implies a physical interaction between the two substances. Furthermore, it mentions the formation of prednisone from prednisolone through oxidation in peripheral tissues, indicating another level of interaction between them, albeit indirect." +9296682,Prednisolone physically interacts with Prednisone,181,CONCLUSION: Dexamethasone or prednisolone were the easiest to induce steroid glaucoma when the patients had long-term use of steroid eyedrops.,False,Is the triple 'Prednisolone physically interacts with Prednisone' supported by the sentence: 'CONCLUSION: Dexamethasone or prednisolone were the easiest to induce steroid glaucoma when the patients had long-term use of steroid eyedrops.'?,"No, it is not directly supported as this statement does not mention any interaction between prednisolone and prednisone, but rather their individual effects in relation to steroid glaucoma in long-term steroid eyedrop users." +27055840,Prednisolone causes glaucoma,182,"Among 121 CK-analogs studied, CK-17, CK-101A and CK103A have been identified as promising anti-inflammatory agents as potent as prednisolone in inhibiting lens proteins-induced inflammation and twice as potent as prednisolone in inhibiting endotoxin-and IL-1-induced uveitis.",False,"Is the triple 'Prednisolone causes glaucoma' supported by the sentence: 'Among 121 CK-analogs studied, CK-17, CK-101A and CK103A have been identified as promising anti-inflammatory agents as potent as prednisolone in inhibiting lens proteins-induced inflammation and twice as potent as prednisolone in inhibiting endotoxin-and IL-1-induced uveitis.'?","No, this statement does not provide any evidence that Prednisolone causes glaucoma, directly or indirectly. It discusses the anti-inflammatory properties of Prednisolone and some other compounds, but does not mention any relationship to glaucoma." +26677891,Prednisolone causes uveitis,183,Light and electron microscopy of prednisolone-induced nephropathy in rabbits.,False,Is the triple 'Prednisolone causes uveitis' supported by the sentence: 'Light and electron microscopy of prednisolone-induced nephropathy in rabbits.'?,"No, that statement does not provide support for the claim that Prednisolone causes uveitis. It discusses nephropathy in rabbits, not uveitis in any species." +25953223,Prednisolone causes kidney disorder,184,The behavior results showed that exposure to prednisolone resulted in decreased autonomic activity and low sensitivity to light.,False,Is the triple 'Prednisolone causes kidney disorder' supported by the sentence: 'The behavior results showed that exposure to prednisolone resulted in decreased autonomic activity and low sensitivity to light.'?,"No, it is not directly supported as there is no explicit mention of a causal relationship between Prednisolone use and kidney disorders in this statement, nor any indication of a physiological pathway through which such an effect could occur via autonomic activity or light sensitivity changes. However, it is possible for Prednisolone, a corticosteroid, to have side effects on various organs, including the kidneys, but this would require further investigation beyond this statement alone." +21556285,Prednisolone causes allergic disease,185,We therefore advocate for increased clinical alertness towards prednisolone-induced adrenal insufficiency in RTx patients and thus their potential need of rescue GC supplementation during stress.,False,Is the triple 'Prednisolone causes allergic disease' supported by the sentence: 'We therefore advocate for increased clinical alertness towards prednisolone-induced adrenal insufficiency in RTx patients and thus their potential need of rescue GC supplementation during stress.'?,"No, it is not directly or indirectly supported by that sentence, as it discusses adrenal insufficiency, not allergies." +21293782,Prednisolone causes adrenocortical insufficiency,186,Zeaxanthin (50 mg/kg/day) or prednisolone (5 mg/kg/day) was orally administered for 14 days before induction of ulcerative colitis.,False,Is the triple 'Prednisolone causes adrenocortical insufficiency' supported by the sentence: 'Zeaxanthin (50 mg/kg/day) or prednisolone (5 mg/kg/day) was orally administered for 14 days before induction of ulcerative colitis.'?,"No, it is not directly supported because there is no mention of prednisolone causing adrenocortical insufficiency in this sentence. It just states that prednisolone was administered for 14 days before induction of ulcerative colitis, but it does not specify any side effects like adrenocortical insufficiency caused by prednisolone in this context." +20789636,Prednisolone causes ulcerative colitis,187,"OBJECTIVE: We want to show that an intralesional injection of prednisolone into the proximal nail fold may produce dorsal pain, dyspnoea and headaches within the 2 min following the injection and to explain the pathophysiology of his condition.",False,"Is the triple 'Prednisolone causes ulcerative colitis' supported by the sentence: 'OBJECTIVE: We want to show that an intralesional injection of prednisolone into the proximal nail fold may produce dorsal pain, dyspnoea and headaches within the 2 min following the injection and to explain the pathophysiology of his condition.'?","No, it is not supported because there is no mention of ulcerative colitis in this statement, nor any indication of a causal relationship between prednisolone use and this condition." +17230021,Prednisolone causes Headache,188,[A case of nephrotic syndrome with abnormally high level of protein C induced by prednisolone].,False,Is the triple 'Prednisolone causes Headache' supported by the sentence: '[A case of nephrotic syndrome with abnormally high level of protein C induced by prednisolone].'?,"No, it is not directly nor indirectly supported, as there is no mention in the provided statement about headaches being caused by Prednisolone, nor any correlation between protein C levels and headaches." +16304261,Prednisolone causes nephrotic syndrome,189,It is concluded that six or more cycles of COPP chemotherapy for advanced Hodgkin's disease in men leads to permanent sterility.,False,Is the triple 'Prednisolone causes nephrotic syndrome' supported by the sentence: 'It is concluded that six or more cycles of COPP chemotherapy for advanced Hodgkin's disease in men leads to permanent sterility.'?,"No, it's not directly related. The sentence discusses the impact of COPP chemotherapy on fertility in men with advanced Hodgkin's disease, while the statement about Prednisolone refers to a potential side effect on kidneys, which isn't mentioned in the provided context." +15365269,Prednisolone causes infertility disorder,190,The erythroderma improved generally as a result of systemic prednisolone treatment.,False,Is the triple 'Prednisolone causes infertility disorder' supported by the sentence: 'The erythroderma improved generally as a result of systemic prednisolone treatment.'?,"No, it is not directly or indirectly supported. The improvement of erythroderma through systemic prednisolone treatment does not imply that prednisolone causes infertility disorders." +14373522,Prednisolone causes exfoliative dermatitis,191,CONTACT DERMATITIS DUE TO TOPICAL HYDROCORTISONE AND PREDNISOLONE.,True,Is the triple 'Prednisolone causes exfoliative dermatitis' supported by the sentence: 'CONTACT DERMATITIS DUE TO TOPICAL HYDROCORTISONE AND PREDNISOLONE.'?,"Yes, it is indirectly supported because both Prednisolone and Hydrocortisone are mentioned as causing contact dermatitis, which is a type of skin reaction similar to exfoliative dermatitis. However, it doesn't directly state that Prednisolone causes exfoliative dermatitis." +10735861,Prednisolone causes contact dermatitis,192,[Pulmonary tuberculosis due to prednisolone].,False,Is the triple 'Prednisolone causes contact dermatitis' supported by the sentence: '[Pulmonary tuberculosis due to prednisolone].'?,"No, it is not directly or indirectly supported, as pulmonary tuberculosis is not a form of contact dermatitis. The two conditions, while possibly both caused by prednisolone, are distinct medical issues." +10545904,Prednisolone causes pulmonary tuberculosis,193,"Rats were treated with a leukotriene synthesis inhibitor (PF-5901), a leukotriene B4 receptor antagonist (SC-41930), an IL-1 receptor antagonist or a corticosteroid (prednisolone) prior to induction of colitis.",False,"Is the triple 'Prednisolone causes pulmonary tuberculosis' supported by the sentence: 'Rats were treated with a leukotriene synthesis inhibitor (PF-5901), a leukotriene B4 receptor antagonist (SC-41930), an IL-1 receptor antagonist or a corticosteroid (prednisolone) prior to induction of colitis.'?","No, this statement does not provide evidence that prednisolone causes pulmonary tuberculosis, directly or indirectly. It merely mentions that rats were treated with prednisolone before induction of colitis, but it does not link this treatment to the development of pulmonary tuberculosis." +10519611,Prednisolone causes colitis,194,"PURPOSE: To investigate the relationship between vitamin E deficiency and prednisolone-induced cataract formation, long-term examination of lens changes was performed in rats under the condition of vitamin E deficiency or supplementation and administration of prednisolone.",False,"Is the triple 'Prednisolone causes colitis' supported by the sentence: 'PURPOSE: To investigate the relationship between vitamin E deficiency and prednisolone-induced cataract formation, long-term examination of lens changes was performed in rats under the condition of vitamin E deficiency or supplementation and administration of prednisolone.'?","No, it is not directly or indirectly supported. This statement is about prednisolone-induced cataract formation in rats under conditions of vitamin E deficiency or supplementation, not about prednisolone causing colitis in any form." +9464043,Prednisolone causes cataract,195,"In inactive SLE induced by prednisolone therapy, the invariant Valpha24JalphaQ TCR could be detected in DN Valpha24+ T cells from all the patients and dominated in most of the patients.",False,"Is the triple 'Prednisolone causes cataract' supported by the sentence: 'In inactive SLE induced by prednisolone therapy, the invariant Valpha24JalphaQ TCR could be detected in DN Valpha24+ T cells from all the patients and dominated in most of the patients.'?","No, it is not directly nor indirectly supported by that statement, as it does not mention anything about cataracts being caused by Prednisolone." +8757881,Prednisolone causes systemic lupus erythematosus,196,"Interleukin-1 (IL-1) blockers, CK 127 and CK 129, were found to inhibit IL-1-induced posterior uveitis very effectively at 3-10 mg/kg i.p. and were more potent than prednisolone which required at least 20 mg/kg i.p. to achieve the same level of anti-uveitis action.",False,"Is the triple 'Prednisolone causes systemic lupus erythematosus' supported by the sentence: 'Interleukin-1 (IL-1) blockers, CK 127 and CK 129, were found to inhibit IL-1-induced posterior uveitis very effectively at 3-10 mg/kg i.p. and were more potent than prednisolone which required at least 20 mg/kg i.p. to achieve the same level of anti-uveitis action.'?","No, this statement does not provide evidence to support a direct or indirect link between Prednisolone causing Systemic Lupus Erythematosus (SLE). The statement discusses the efficacy of Interleukin-1 (IL-1) blockers in comparison to Prednisolone in treating posterior uveitis, but it does not mention or imply any connection to SLE." +27658451,Prednisolone affects uveitis,197,[A case of hormone-refractory prostate cancer responsive to low-dose prednisolone therapy].,False,Is the triple 'Prednisolone affects uveitis' supported by the sentence: '[A case of hormone-refractory prostate cancer responsive to low-dose prednisolone therapy].'?,"No, it is not directly supported because there is no mention of uveitis in that statement, but it does provide some evidence for prednisolone's potential effectiveness in treating conditions that may be resistant to other treatments, which could potentially include uveitis." +27410586,Prednisolone affects castration-resistant prostate carcinoma,198,6 cases of FSGS had poor response to any therapy; 7 cases were responsive to either triple therapy or cyclosporine A plus prednisolone.,True,Is the triple 'Prednisolone affects castration-resistant prostate carcinoma' supported by the sentence: '6 cases of FSGS had poor response to any therapy; 7 cases were responsive to either triple therapy or cyclosporine A plus prednisolone.'?,"Yes, it is indirectly supported. The mention of prednisolone in combination with other therapies in treating certain conditions suggests that prednisolone may have an effect, even if it's not directly stated that it affects castration-resistant prostate carcinoma. However, it's important to note that this is a very indirect inference and not based on direct evidence." +27323391,Prednisolone affects focal segmental glomerulosclerosis,199,"From 1983, exacerbation of PIE was recorded three times, on which occasions prednisolone and antibiotics were quite effective.",True,"Is the triple 'Prednisolone affects focal segmental glomerulosclerosis' supported by the sentence: 'From 1983, exacerbation of PIE was recorded three times, on which occasions prednisolone and antibiotics were quite effective.'?","Yes, it is indirectly supported. The sentence suggests that prednisolone was effective in treating exacerbation of PIE (presumably a condition related to kidneys given the context of focal segmental glomerulosclerosis). This implies that prednisolone might have a positive impact on related kidney conditions, such as focal segmental glomerulosclerosis. However, it is important to note that this is an inference based on a single sentence, and more comprehensive research would be needed to establish a definitive conclusion." +27042309,Prednisolone affects pulmonary eosinophilia,200,"A comparative study of the effects of ACTH, hydrocortisone and prednisolone in the hypersensitive reactions produced with the protein components of Hymenolepis nana in albino mice.",True,"Is the triple 'Prednisolone affects pulmonary eosinophilia' supported by the sentence: 'A comparative study of the effects of ACTH, hydrocortisone and prednisolone in the hypersensitive reactions produced with the protein components of Hymenolepis nana in albino mice.'?","Yes, it is indirectly supported. The study mentioned compares the effects of Prednisolone with other substances in hypersensitive reactions, which could be related to pulmonary eosinophilia, a condition often associated with hypersensitivity reactions. However, it does not directly mention or prove the effect of Prednisolone on pulmonary eosinophilia." +25790510,Prednisolone affects allergic disease,201,"Immunosuppressant therapy, such as prednisolone or azathioprine, is considered for exacerbations of highly active glomerulonephritis.",True,"Is the triple 'Prednisolone affects allergic disease' supported by the sentence: 'Immunosuppressant therapy, such as prednisolone or azathioprine, is considered for exacerbations of highly active glomerulonephritis.'?","Yes, it is indirectly supported. The statement mentions that immunosuppressants like Prednisolone are used in exacerbations of glomerulonephritis, which is an inflammatory kidney disease often caused by an autoimmune reaction - a type of allergy to one's own body tissues. Therefore, Prednisolone's use in this context suggests its role in managing certain types of allergic diseases." +25165576,Prednisolone affects glomerulonephritis,202,"We describe a 57-year-old Caucasian male with anti-MDA5 positive dermatomyositis, that had a 4-month history of progressive dyspnoea requiring oxygen-therapy, scarcely responsive to prednisolone.",True,"Is the triple 'Prednisolone affects glomerulonephritis' supported by the sentence: 'We describe a 57-year-old Caucasian male with anti-MDA5 positive dermatomyositis, that had a 4-month history of progressive dyspnoea requiring oxygen-therapy, scarcely responsive to prednisolone.'?","Yes, it is indirectly supported. The mention of prednisolone in relation to anti-MDA5 positive dermatomyositis, which can be associated with glomerulonephritis, suggests a possible connection, although it does not directly state that prednisolone affects glomerulonephritis in this context." +24270725,Prednisolone affects dermatomyositis,203,"After 14 months of treatment one of the patients developed severe, acute exacerbation of the ABPA and was treated with high-dose prednisolone and local steroid.",True,"Is the triple 'Prednisolone affects dermatomyositis' supported by the sentence: 'After 14 months of treatment one of the patients developed severe, acute exacerbation of the ABPA and was treated with high-dose prednisolone and local steroid.'?","Yes, it is indirectly supported, as it mentions a patient being treated with Prednisolone for a condition related to their dermatomyositis (ABPA). However, it does not provide direct evidence on Prednisolone's effect on dermatomyositis itself." +22922261,Prednisolone affects allergic bronchopulmonary aspergillosis,204,"The effect of pretreatment with topical prostaglandin E2, prednisolone and sulphasalazine in experimental colitis has been examined in the rat colon.",False,"Is the triple 'Prednisolone affects allergic bronchopulmonary aspergillosis' supported by the sentence: 'The effect of pretreatment with topical prostaglandin E2, prednisolone and sulphasalazine in experimental colitis has been examined in the rat colon.'?","No, this statement does not provide support for the claim that prednisolone affects allergic bronchopulmonary aspergillosis, directly or indirectly. The statement discusses the effects of pretreatment with various substances, including prednisolone, in experimental colitis in rats, not in allergic bronchopulmonary aspergillosis in any species." +19824794,Prednisolone affects colitis,205,"Here, we report a case of prednisolone-dependent gastric sarcoidosis that improved after additional azathioprine, and also review the literature concerning the treatment, especially for prednisolone-dependent cases.",True,"Is the triple 'Prednisolone affects colitis' supported by the sentence: 'Here, we report a case of prednisolone-dependent gastric sarcoidosis that improved after additional azathioprine, and also review the literature concerning the treatment, especially for prednisolone-dependent cases.'?","Yes. The provided statement suggests that prednisolone is used in treating gastric sarcoidosis but the patient was dependent on it. The addition of azathioprine improved the condition, indicating that other treatments (like azathioprine) can be beneficial in managing prednisolone-dependent cases. This is indirectly supportive of the idea that prednisolone affects colitis because sarcoidosis and colitis can both involve inflammation in the gastrointestinal tract, and treatments for one may also be relevant for the other. However, it's important to note that this is an inference based on related conditions; for direct evidence on prednisolone's effect on colitis, studies specifically addressing this question would need to be examined." +19409335,Prednisolone affects sarcoidosis,206,"METHODS: In 126 adults (33 healthy control subjects, 31 patients with mild asthma, 32 patients with severe asthma, and 30 patients with prednisolone-dependent asthma) parameters of inflammation (peripheral blood eosinophils and neutrophils) and markers of hemostasis (endogenous thrombin potential [ETP], thrombin-antithrombin complex, plasmin-alpha2-antiplasmin complex, plasminogen activator inhibitor type 1 [PAI-1], D-dimer, and von Willebrand factor [vWF]) were measured in plasma.",False,"Is the triple 'Prednisolone affects sarcoidosis' supported by the sentence: 'METHODS: In 126 adults (33 healthy control subjects, 31 patients with mild asthma, 32 patients with severe asthma, and 30 patients with prednisolone-dependent asthma) parameters of inflammation (peripheral blood eosinophils and neutrophils) and markers of hemostasis (endogenous thrombin potential [ETP], thrombin-antithrombin complex, plasmin-alpha2-antiplasmin complex, plasminogen activator inhibitor type 1 [PAI-1], D-dimer, and von Willebrand factor [vWF]) were measured in plasma.'?","No, this statement does not directly support that Prednisolone affects sarcoidosis as it does not mention anything about sarcoidosis, but it does mention prednisolone in relation to asthma patients, specifically those with prednisolone-dependent asthma." +18736907,Prednisolone affects asthma,207,Previous studies from our laboratory revealed that coadministration of EP significantly increased the plasma concentration of prednisolone while decreased the level of cotreated prednisone in rats.,True,Is the triple 'Prednisolone affects asthma' supported by the sentence: 'Previous studies from our laboratory revealed that coadministration of EP significantly increased the plasma concentration of prednisolone while decreased the level of cotreated prednisone in rats.'?,"Yes, it is indirectly supported because if EP increases plasma concentration of Prednisolone, it suggests Prednisolone's effectiveness in treating conditions it's used for, such as asthma, could be enhanced with EP. However, this doesn't directly prove Prednisolone's effect on asthma, but rather implies a potential mechanism for improved efficacy when used in combination with EP." +17668631,Prednisolone affects Prednisone,208,Metabolic effects of high-dose prednisolone treatment in early rheumatoid arthritis: balance between diabetogenic effects and inflammation reduction.,True,Is the triple 'Prednisolone affects Prednisone' supported by the sentence: 'Metabolic effects of high-dose prednisolone treatment in early rheumatoid arthritis: balance between diabetogenic effects and inflammation reduction.'?,"Yes, it is indirectly supported because both Prednisolone and Prednisone belong to a class of drugs called corticosteroids, which can have similar metabolic effects, such as diabetogenic effects mentioned in the title. However, for a direct correlation, a specific comparison between these two drugs would be needed in the context provided." +15888410,Prednisolone affects rheumatoid arthritis,209,"Effects of prednisolone, salbutamol and theophylline on bronchial hyperreactivity and leucocyte chemokinesis in guinea pigs.",False,"Is the triple 'Prednisolone affects rheumatoid arthritis' supported by the sentence: 'Effects of prednisolone, salbutamol and theophylline on bronchial hyperreactivity and leucocyte chemokinesis in guinea pigs.'?","No, this statement does not provide direct evidence that Prednisolone affects Rheumatoid Arthritis, as it discusses its effects on bronchial hyperreactivity and leucocyte chemokinesis in guinea pigs, not on Rheumatoid Arthritis specifically." +13564625,Prednisolone affects asthma,210,"This is the first case to support the beneficial effect of prednisolone in pericarditis with pSS, and illustrates its safety during pregnancy.",True,"Is the triple 'Prednisolone affects asthma' supported by the sentence: 'This is the first case to support the beneficial effect of prednisolone in pericarditis with pSS, and illustrates its safety during pregnancy.'?","Yes, it could be interpreted as indirect evidence, as it suggests that Prednisolone was safe during pregnancy, which could potentially be relevant for pregnant women with asthma who might be prescribed this medication for pericarditis with pSS. However, it does not directly address how Prednisolone affects asthma itself." +13234063,Prednisolone affects pericarditis,211,"When combined with environmental control, prednisolone and dexamethasone treatments had similar effects on heaves score, blood gases and endoscopic scores.",True,"Is the triple 'Prednisolone affects pericarditis' supported by the sentence: 'When combined with environmental control, prednisolone and dexamethasone treatments had similar effects on heaves score, blood gases and endoscopic scores.'?","Yes, it is indirectly supported because both prednisolone and dexamethasone are corticosteroids, which can have similar effects on inflammatory conditions such as pericarditis. However, the original sentence does not directly mention pericarditis but another inflammatory condition (heaves score)." +13029310,Prednisolone affects chronic obstructive pulmonary disease,212,"Of the 20 patients, 14 initially received prednisolone treatment, which resulted in rapid improvement and normalization of eosinophilia within 8 weeks; however, 2 patients with splenomegaly showed poor control of eosinophilia in response to corticosteroid treatment.",True,"Is the triple 'Prednisolone affects chronic obstructive pulmonary disease' supported by the sentence: 'Of the 20 patients, 14 initially received prednisolone treatment, which resulted in rapid improvement and normalization of eosinophilia within 8 weeks; however, 2 patients with splenomegaly showed poor control of eosinophilia in response to corticosteroid treatment.'?","Yes, this statement does provide some support for the idea that prednisolone can affect chronic obstructive pulmonary disease (COPD), although it's important to note that COPD is not explicitly mentioned in the provided context. The sentence suggests that prednisolone can improve eosinophilia (a condition often associated with COPD) within a certain time frame. However, it also mentions that some patients with splenomegaly did not respond well to corticosteroid treatment (which prednisolone is a part of), indicating potential limitations in its effectiveness. Therefore, while there's some support for an indirect relationship between prednisolone and COPD management, it's not a direct correlation and further research would be needed to make a definitive conclusion." +12949384,Prednisolone affects hypereosinophilic syndrome,213,Complement activation capacity in plasma before and during high-dose prednisolone treatment and tapering in exacerbations of Crohn's disease and ulcerative colitis.,False,Is the triple 'Prednisolone affects hypereosinophilic syndrome' supported by the sentence: 'Complement activation capacity in plasma before and during high-dose prednisolone treatment and tapering in exacerbations of Crohn's disease and ulcerative colitis.'?,"No, it is not directly supported as hypereosinophilic syndrome is not mentioned nor implied in the provided sentence about Crohn's disease, ulcerative colitis, and prednisolone treatment." +12057849,Prednisolone affects Crohn disease,214,Prednisolone-responsive headache in patients with solitary cysticercus granuloma and seizures.,False,Is the triple 'Prednisolone affects Crohn disease' supported by the sentence: 'Prednisolone-responsive headache in patients with solitary cysticercus granuloma and seizures.'?,"No, it is not directly supported because it refers to a different medical condition (headaches associated with cysticercus granuloma) rather than Crohn's disease, which is what the original statement is about." +11166436,Prednisolone affects Headache,215,"The patient was treated with chemotherapy by cyclophosphamide, hydroxydoxorubicin, vincristine and prednisolone (CHOP), however, it was ineffective, and the patient died of hemorrhage from the lymphoma involvement of the intestine 5 months after the onset of disease.",False,"Is the triple 'Prednisolone affects Headache' supported by the sentence: 'The patient was treated with chemotherapy by cyclophosphamide, hydroxydoxorubicin, vincristine and prednisolone (CHOP), however, it was ineffective, and the patient died of hemorrhage from the lymphoma involvement of the intestine 5 months after the onset of disease.'?","No, it is not directly nor indirectly supported. The given statement discusses a case of a patient who received treatment for lymphoma, including prednisolone, but died due to hemorrhage from intestinal lymphoma involvement without mentioning any connection to headaches." +11074135,Prednisolone affects lymphoma,216,Effect of prednisolone in the experimentally induced nephropathy in male albino rats.,False,Is the triple 'Prednisolone affects lymphoma' supported by the sentence: 'Effect of prednisolone in the experimentally induced nephropathy in male albino rats.'?,"No, that statement does not provide direct support for the claim that Prednisolone affects lymphoma. It discusses the effect of Prednisolone on nephropathy in male albino rats, not on lymphoma." +10651502,Prednisolone affects kidney disorder,217,[On the effect of oral use of prednisolone on central chorioretinitis].,False,Is the triple 'Prednisolone affects kidney disorder' supported by the sentence: '[On the effect of oral use of prednisolone on central chorioretinitis].'?,"No, that statement does not provide support for the claim that Prednisolone affects kidney disorders, whether directly or indirectly. It specifically mentions central chorioretinitis, not kidney disorders." +10649036,Prednisolone affects chorioretinitis,218,Peptic ulceration associated with prednisolone therapy.,False,Is the triple 'Prednisolone affects chorioretinitis' supported by the sentence: 'Peptic ulceration associated with prednisolone therapy.'?,"No, it is not directly related. The second statement is about peptic ulcers being associated with prednisolone therapy, while the first statement is about Prednisolone affecting chorioretinitis, which is an eye condition." +10555139,Prednisolone affects peptic ulcer disease,219,"Glucocorticoids (e.g. prednisolone) are cornerstones in the treatment of acute exacerbations of ulcerative colitis (UC), and influence of the leucocyte/endothelial interaction appears to be part of their mode of action.",True,"Is the triple 'Prednisolone affects peptic ulcer disease' supported by the sentence: 'Glucocorticoids (e.g. prednisolone) are cornerstones in the treatment of acute exacerbations of ulcerative colitis (UC), and influence of the leucocyte/endothelial interaction appears to be part of their mode of action.'?","Yes, it is indirectly supported because prednisolone, a glucocorticoid, is mentioned as a treatment for acute exacerbations of ulcerative colitis, which is a type of inflammatory bowel disease that can cause ulcers in the digestive tract, including the stomach and duodenum, which are parts of the digestive system where peptic ulcers can occur. However, it does not directly mention peptic ulcers but rather a different type of ulcers in a different context." +10183156,Prednisolone affects ulcerative colitis,220,"Effects of honey, prednisolone, and disulfiram on inflammation, nitric oxide, and free radical formation.",False,"Is the triple 'Prednisolone affects ulcerative colitis' supported by the sentence: 'Effects of honey, prednisolone, and disulfiram on inflammation, nitric oxide, and free radical formation.'?","No, it is not directly supported because although it mentions Prednisolone which is a drug used to treat Ulcerative Colitis, it does not mention Ulcerative Colitis directly in that sentence." +9735520,Prednisolone affects Inflammation,221,OBJECTIVE: To assess the treatment effect of sodium hyaluronate (HA) on experimental temporomandibular joint (TMJ) osteoarthritis of rabbits in comparison with prednisolone (PS).,True,Is the triple 'Prednisolone affects Inflammation' supported by the sentence: 'OBJECTIVE: To assess the treatment effect of sodium hyaluronate (HA) on experimental temporomandibular joint (TMJ) osteoarthritis of rabbits in comparison with prednisolone (PS).'?,"Yes, it is indirectly supported because it mentions prednisolone in relation to an experimental osteoarthritis study, implying its involvement in inflammatory conditions, which is a part of its broader effects on inflammation in general." +9361682,Prednisolone affects osteoarthritis,222,"ETO+PSL combination treatment, however, failed to show significant enhancement of anti-tumor effects.",False,"Is the triple 'Prednisolone affects osteoarthritis' supported by the sentence: 'ETO+PSL combination treatment, however, failed to show significant enhancement of anti-tumor effects.'?","No, it is not directly related. The statement refers to an ETO + PSL (Etoposide + Prednisolone) combination's effect on anti-tumor effects, not its impact on osteoarthritis." +8533593,Prednisolone affects neoplasm,223,"My- and My+ ALL did not significantly differ in sensitivity to prednisolone, dexamethasone, L-asparaginase and cytarabine.",False,"Is the triple 'Prednisolone affects neoplasm' supported by the sentence: 'My- and My+ ALL did not significantly differ in sensitivity to prednisolone, dexamethasone, L-asparaginase and cytarabine.'?","No, it is not directly nor indirectly supported, as there is no correlation established between prednisolone affecting neoplasm (a type of cancer) and the given statement about sensitivities of certain types of leukemia to various drugs, including prednisolone." +7800426,Prednisolone affects acute lymphoblastic leukemia,224,"The dose of prednisolone was increased considering he was exacerbated of SLE, however, the convulsion as CNS lupus occurred to him.",False,"Is the triple 'Prednisolone affects acute lymphoblastic leukemia' supported by the sentence: 'The dose of prednisolone was increased considering he was exacerbated of SLE, however, the convulsion as CNS lupus occurred to him.'?","No, this sentence does not provide direct support for the statement that Prednisolone affects acute lymphoblastic leukemia (ALL). The sentence discusses a patient with Systemic Lupus Erythematosus (SLE) who experienced a convulsion, which is associated with Central Nervous System (CNS) lupus, after an increase in Prednisolone dosage. While this information is relevant to SLE, it does not establish a connection between Prednisolone and ALL." +7395227,Prednisolone affects systemic lupus erythematosus,225,"In a pilot study using one rabbit, prednisone and prednisolone clearance values increased with increase in either prednisone or prednisolone infusion rates.",False,"Is the triple 'Prednisolone affects systemic lupus erythematosus' supported by the sentence: 'In a pilot study using one rabbit, prednisone and prednisolone clearance values increased with increase in either prednisone or prednisolone infusion rates.'?","No, this statement does not directly support the idea that prednisolone affects systemic lupus erythematosus (SLE). The sentence you provided discusses how clearance values of prednisone and prednisolone change with increased infusion rates in a single rabbit study, but it does not mention or imply any connection to SLE, which is a complex autoimmune disease affecting various organ systems in humans." +21722189,Prednisolone affects Prednisone,226,"Budesonide is equal to less effective than prednisolone or prednisone therapy in the treatment of active Crohn's disease, but is associated with fewer glucocorticoids adverse reactions.",True,"Is the triple 'Prednisolone affects Prednisone' supported by the sentence: 'Budesonide is equal to less effective than prednisolone or prednisone therapy in the treatment of active Crohn's disease, but is associated with fewer glucocorticoids adverse reactions.'?","Yes, it is indirectly supported because both Prednisolone and Prednisone belong to a class of medications called glucocorticoids, which Budesonide has been compared to in terms of effectiveness and adverse reactions in this statement." +9655099,Prednisolone has input Prednisone,227,Diclofenac and prednisolone inhibit endotoxin-induced uveitis in rabbits.,False,Is the triple 'Prednisolone has input Prednisone' supported by the sentence: 'Diclofenac and prednisolone inhibit endotoxin-induced uveitis in rabbits.'?,"No, it is not directly nor indirectly supported as there is no mention of Prednisone in this statement, which is required to establish a link between Diclofenac, Prednisolone, and Prednisone as per your request." +27206106,Prednisolone disrupts uveitis,228,"Although prednisolone and GH reverse hypoglycemia by different mechanisms, with only prednisolone suppressing tumor IGF-II secretion, both increase the formation of ternary IGF-IGFBP-3 complexes.",True,"Is the triple 'Prednisolone disrupts uveitis' supported by the sentence: 'Although prednisolone and GH reverse hypoglycemia by different mechanisms, with only prednisolone suppressing tumor IGF-II secretion, both increase the formation of ternary IGF-IGFBP-3 complexes.'?","Yes, it is indirectly supported. The statement suggests that both Prednisolone and GH can increase the formation of ternary IGF-IGFBP-3 complexes, which could potentially have an impact on uveitis, given that IGF-II has been implicated in its pathogenesis. However, a direct causal link is not established in this statement." +26515767,Prednisolone disrupts neoplasm,229,"The aqueous extract of Saiboku-to also showed an inhibition of the contact dermatitis, and it significantly potentiated the inhibition of contact dermatitis by prednisolone.",True,"Is the triple 'Prednisolone disrupts neoplasm' supported by the sentence: 'The aqueous extract of Saiboku-to also showed an inhibition of the contact dermatitis, and it significantly potentiated the inhibition of contact dermatitis by prednisolone.'?","Yes, it is indirectly supported because it suggests that Prednisolone has an effect on contact dermatitis, which could be related to its potential impact on neoplasms, given that both are related to inflammation and immune response. However, it's important to note that this is an indirect inference and not a direct correlation, as the original sentence does not mention neoplasms." +26379811,Prednisolone disrupts contact dermatitis,230,Only hydrocortisone and prednisolone suppressed LPS pneumonia.,True,Is the triple 'Prednisolone disrupts contact dermatitis' supported by the sentence: 'Only hydrocortisone and prednisolone suppressed LPS pneumonia.'?,"Yes, it is indirectly supported because both sentences discuss the effects of corticosteroids (hydrocortisone and prednisolone) on inflammatory responses, even though they refer to different conditions (LPS pneumonia in this case). However, it does not directly support the specific claim about contact dermatitis." +25763558,Prednisolone disrupts pneumonia,231,"Prednisolone significantly inhibited the measurable sensitivity of IDT, while oclacitinib did not.",True,"Is the triple 'Prednisolone disrupts pneumonia' supported by the sentence: 'Prednisolone significantly inhibited the measurable sensitivity of IDT, while oclacitinib did not.'?","Yes, it is indirectly supported because Prednisolone's significant inhibition of IDT sensitivity implies that it may have an impact on certain conditions, such as pneumonia, given that IDT is a crucial component of immune response in respiratory infections like pneumonia. However, a direct causal link cannot be established solely based on this information, as further research would be required to determine Prednisolone's specific effects on pneumonia." +25233555,Prednisolone disrupts allergic disease,232,"A comparison with the bronchodilator potency of the above drugs indicated that in guinea pigs salbutamol appears relatively selective as a bronchodilator, prednisolone is selective as an inhibitor of eosinophilia whilst theophylline displays a balance of both activities.",True,"Is the triple 'Prednisolone disrupts allergic disease' supported by the sentence: 'A comparison with the bronchodilator potency of the above drugs indicated that in guinea pigs salbutamol appears relatively selective as a bronchodilator, prednisolone is selective as an inhibitor of eosinophilia whilst theophylline displays a balance of both activities.'?","Yes, the statement supports it indirectly. It indicates that Prednisolone has a selective effect on inhibiting eosinophilia, which is a characteristic feature of allergic diseases, thus supporting the claim that it can disrupt allergic diseases, albeit indirectly." +14331279,Prednisolone disrupts hypereosinophilic syndrome,233,Reduction of maintenance doses of prednisolone in bronchial asthma by the concurrent use of hydroxyzine.,False,Is the triple 'Prednisolone disrupts hypereosinophilic syndrome' supported by the sentence: 'Reduction of maintenance doses of prednisolone in bronchial asthma by the concurrent use of hydroxyzine.'?,"No, it is not directly supported, as this statement is specifically referring to bronchial asthma, not hypereosinophilic syndrome. However, it does suggest that prednisolone can be used in conjunction with other medications to manage conditions, which could be interpreted as a form of indirect support for its use in managing hypereosinophilic syndrome, depending on the broader context." +10594561,Prednisolone disrupts asthma,234,"In contrast, cyclosporin A (CyA), FK-506 and prednisolone significantly inhibited antigen-induced airway inflammation and BHR in sensitized BN rats.",True,"Is the triple 'Prednisolone disrupts asthma' supported by the sentence: 'In contrast, cyclosporin A (CyA), FK-506 and prednisolone significantly inhibited antigen-induced airway inflammation and BHR in sensitized BN rats.'?","Yes, it is indirectly supported because prednisolone is shown to significantly inhibit antigen-induced airway inflammation and bronchial hyperresponsiveness (BHR) in sensitized Brown Norway (BN) rats in this statement. This suggests that prednisolone has a role in managing asthma symptoms, which aligns with the idea that prednisolone can disrupt asthma. However, it's important to note that this statement refers to a specific animal model and may not directly translate to humans." +8854473,Prednisolone disrupts Inflammation,235,[Use of corticosteroids betamethasone and prednisolone in the prevention of allergic reactions in patients undergoing heart surgery with artificial blood circulation].,True,Is the triple 'Prednisolone disrupts Inflammation' supported by the sentence: '[Use of corticosteroids betamethasone and prednisolone in the prevention of allergic reactions in patients undergoing heart surgery with artificial blood circulation].'?,"Yes, it is indirectly supported. The use of prednisolone in preventing allergic reactions in heart surgery patients suggests that it has an anti-inflammatory effect, which aligns with the statement that prednisolone disrupts inflammation. However, it's important to note that this is an indirect inference, as the original sentence does not explicitly state that prednisolone disrupts inflammation in the context of allergic reactions or heart surgery." +27646185,Prednisolone prevents allergic disease,236,The intra-articular injection of prednisolone was shown to considerably reduce incidence of synovitis.,True,Is the triple 'Prednisolone prevents allergic disease' supported by the sentence: 'The intra-articular injection of prednisolone was shown to considerably reduce incidence of synovitis.'?,"Yes, it is indirectly supported. The provided sentence suggests that Prednisolone has an effect on reducing synovitis incidence, which could be interpreted as an overall positive impact on inflammation, including allergic inflammation, given that both synovitis and allergy involve inflammatory processes. However, this is a weak association, as synovitis is a specific joint condition, while allergic diseases encompass a broader range of conditions." +26227245,Prednisolone prevents synovitis,237,"Prednisolone (100 mg/die initially, decreasing doses thereafter) led to significant reduction of infiltrates and eosinophilia.",True,"Is the triple 'Prednisolone prevents synovitis' supported by the sentence: 'Prednisolone (100 mg/die initially, decreasing doses thereafter) led to significant reduction of infiltrates and eosinophilia.'?","Yes, it is indirectly supported. The reduction of infiltrates and eosinophilia suggests a decrease in inflammation, which is a characteristic of synovitis. However, it does not explicitly state that Prednisolone prevents synovitis, but rather that it has a significant impact on symptoms associated with it." +19453072,Prednisolone prevents hypereosinophilic syndrome,238,The tumour was significantly reduced by prednisolone.,True,Is the triple 'Prednisolone prevents hypereosinophilic syndrome' supported by the sentence: 'The tumour was significantly reduced by prednisolone.'?,"Yes, it is indirectly supported because prednisolone's ability to reduce the tumor suggests it has some effect on the condition, which could include preventing or mitigating hypereosinophilic syndrome if that is what the tumor is associated with. However, it does not directly state that prednisolone prevents hypereosinophilic syndrome." +16706850,Prednisolone prevents neoplasm,239,"Prednisolone prevented the development of colitis, but had no effect on already-developed colitis.",False,"Is the triple 'Prednisolone prevents neoplasm' supported by the sentence: 'Prednisolone prevented the development of colitis, but had no effect on already-developed colitis.'?","No, it is not directly supported because there is no mention of neoplasm in the provided statement about Prednisolone preventing the development of colitis but not affecting already-developed colitis." +15809068,Prednisolone prevents colitis,240,Alveolar NO concentration was increased in patients with refractory asthma (7.1 ppb) compared with mild-to-moderate asthma (3.4 ppb) and normal controls (3.4 ppb) and reduced by treatment with prednisolone.,True,Is the triple 'Prednisolone prevents colitis' supported by the sentence: 'Alveolar NO concentration was increased in patients with refractory asthma (7.1 ppb) compared with mild-to-moderate asthma (3.4 ppb) and normal controls (3.4 ppb) and reduced by treatment with prednisolone.'?,"Yes, it is indirectly supported. The statement suggests that Prednisolone reduces Alveolar NO concentration, which is known to be elevated in inflammatory conditions like asthma and potentially colitis, given their shared inflammatory pathways. However, a direct cause-effect relationship between Prednisolone and colitis prevention is not explicitly stated in this sentence." +11858005,Prednisolone prevents asthma,241,"Prednisolone treatment of sensory impairment of the ulnar and posterior tibial nerves detectable with the monofilament test, but not with the ballpen test, did not improve the long-term outcome in terms of recovery of touch sensibility, not did it reduce the risk of leprosy reactions or nerve function impairment beyond the initial 4-month treatment phase.",False,"Is the triple 'Prednisolone prevents asthma' supported by the sentence: 'Prednisolone treatment of sensory impairment of the ulnar and posterior tibial nerves detectable with the monofilament test, but not with the ballpen test, did not improve the long-term outcome in terms of recovery of touch sensibility, not did it reduce the risk of leprosy reactions or nerve function impairment beyond the initial 4-month treatment phase.'?","No, it is not directly nor indirectly supported because there is no mentioning of asthma in this given statement, nor a correlation between prednisolone treatment, nerve function, and a reduction in risk for leprosy reactions, which could potentially be linked to a reduction in risk for asthma attacks." +10983909,Prednisolone prevents leprosy,242,CONCLUSIONS: Predocol is an oral preparation of a poorly absorbed salt of prednisolone that is effective in reducing inflammation over short treatment periods in patients with active ulcerative colitis.,False,Is the triple 'Prednisolone prevents leprosy' supported by the sentence: 'CONCLUSIONS: Predocol is an oral preparation of a poorly absorbed salt of prednisolone that is effective in reducing inflammation over short treatment periods in patients with active ulcerative colitis.'?,"No, it's not directly supported because the sentence refers to the use of predicol (a form of prednisolone) in treating ulcerative colitis, not leprosy." +10240036,Prednisolone prevents Inflammation,243,"Six weeks prior to his symptoms, prednisolone (PSL) and SASP had been started because of UC aggravation.",True,"Is the triple 'Prednisolone prevents Inflammation' supported by the sentence: 'Six weeks prior to his symptoms, prednisolone (PSL) and SASP had been started because of UC aggravation.'?","Yes, it is indirectly supported because it suggests that taking Prednisolone (PSL) is associated with a reduction in UC (Ulcerative Colitis) aggravation, which can be interpreted as an anti-inflammatory effect. However, it's important to note that this is an inference based on a single statement, and a direct cause-effect relationship cannot be established without further evidence." +18452194,Prednisolone exacerbates ulcerative colitis,244,"When comparing organ specific, age-adjusted expected versus observed incidences after natural death of animals an increased tumor risk was found in organ systems of all treatment modalities but prednisolone.",False,"Is the triple 'Prednisolone exacerbates ulcerative colitis' supported by the sentence: 'When comparing organ specific, age-adjusted expected versus observed incidences after natural death of animals an increased tumor risk was found in organ systems of all treatment modalities but prednisolone.'?","No, it is not. The mentioned sentence suggests that prednisolone does not increase tumor risk in contrast to other treatment modalities in animals. Therefore, it does not support the statement that prednisolone exacerbates ulcerative colitis." +25753407,Prednisolone predisposes neoplasm,245,"R-CHOP chemotherapy composed of rituximab, cyclophosphamide, adriamycin, vincristine, and prednisolone which might increase the risk of Pneumocystis pneumonia in patients with non-Hodgkin lymphoma.",True,"Is the triple 'Prednisolone predisposes neoplasm' supported by the sentence: 'R-CHOP chemotherapy composed of rituximab, cyclophosphamide, adriamycin, vincristine, and prednisolone which might increase the risk of Pneumocystis pneumonia in patients with non-Hodgkin lymphoma.'?","Yes, it is indirectly supported. The statement mentions that Prednisolone is a component of R-CHOP chemotherapy, which might increase the risk of Pneumocystis pneumonia in patients with non-Hodgkin lymphoma. This suggests that Prednisolone could potentially have an impact on patient health, including possibly contributing to a higher risk of certain conditions like neoplasms, although it does not directly state this relationship." +16546227,Prednisolone predisposes pneumonia,246,"Cortisol deficiency is common in late stage HIV disease, but symptoms of fatigue and postural hypotension, as well as biochemical findings, are poor predictors of cortisol deficiency.",False,"Is the triple 'Prednisolone predisposes pneumonia' supported by the sentence: 'Cortisol deficiency is common in late stage HIV disease, but symptoms of fatigue and postural hypotension, as well as biochemical findings, are poor predictors of cortisol deficiency.'?","No, it's not directly supported because there's no mention of Prednisolone, a synthetic glucocorticoid, or its relationship to pneumonia in this sentence about cortisol deficiency in late-stage HIV disease." +27027571,Hydrocortisone related to HIV infectious disease,247,[Plasma cortisol and 17-ketosteroids in urine in relation to cardiac arrest].,False,Is the triple 'Hydrocortisone related to HIV infectious disease' supported by the sentence: '[Plasma cortisol and 17-ketosteroids in urine in relation to cardiac arrest].'?,"No, there is no direct or indirect mention of Hydrocortisone or its relation to HIV infectious disease in the provided sentence about plasma cortisol, urinary 17-ketosteroids, and cardiac arrest." +25927636,Hydrocortisone related to cardiac arrest,248,"Independence of theta and TL surface antigens and killing by thymidine, cortisol, phytohemagglutinin, and cyclic AMP in a murine lymphoma.",False,"Is the triple 'Hydrocortisone related to cardiac arrest' supported by the sentence: 'Independence of theta and TL surface antigens and killing by thymidine, cortisol, phytohemagglutinin, and cyclic AMP in a murine lymphoma.'?","No, this statement does not provide any direct or indirect support for a relationship between Hydrocortisone and cardiac arrest. The sentence you provided discusses the independence of certain antigens, killing by thymidine, cortisol, phytohemagglutinin, and cyclic AMP in a murine lymphoma, which is not relevant to Hydrocortisone's potential impact on cardiac function." +25797574,Hydrocortisone related to lymphoma,249,"Furthermore, this treatment process demonstrated the superior anti-inflammatory effect of prednisolone over that of hydrocortisone and supported the assumption of inflammation related to CD.",False,"Is the triple 'Hydrocortisone related to lymphoma' supported by the sentence: 'Furthermore, this treatment process demonstrated the superior anti-inflammatory effect of prednisolone over that of hydrocortisone and supported the assumption of inflammation related to CD.'?","No, it does not support a direct link between hydrocortisone and lymphoma. The sentence discusses the superior anti-inflammatory effect of prednisolone over hydrocortisone in relation to CD (which is not specified but could be a disease condition), implying potential use in inflammation management. It does not mention or imply any connection between hydrocortisone and lymphoma." +25131277,Hydrocortisone related to Crohn disease,250,"Ordinary least squared (OLS) regression was used to evaluate whether race moderated the associations between alcohol abuse and four biomarkers-urinary cortisol and serum dehydroepiandrosterone sulfate (DHEA-S), epinephrine and norepinephrine-and two composite summary scores, each consisting of two components that characterize the hypothalamic pituitary adrenal (HPA)-axis and sympathetic nervous systems (SNS), respectively.",False,"Is the triple 'Hydrocortisone related to Crohn disease' supported by the sentence: 'Ordinary least squared (OLS) regression was used to evaluate whether race moderated the associations between alcohol abuse and four biomarkers-urinary cortisol and serum dehydroepiandrosterone sulfate (DHEA-S), epinephrine and norepinephrine-and two composite summary scores, each consisting of two components that characterize the hypothalamic pituitary adrenal (HPA)-axis and sympathetic nervous systems (SNS), respectively.'?","No, this statement does not provide direct evidence that hydrocortisone is related to Crohn's disease. It discusses a study using OLS regression to evaluate whether race moderates the associations between alcohol abuse and four biomarkers, including urinary cortisol, but it does not mention Crohn's disease." +19793698,Hydrocortisone related to alcohol abuse,251,"CONCLUSION: In patients with septic shock, low-dose hydrocortisone was associated with a lower risk of developing AF during the acute phase.",False,"Is the triple 'Hydrocortisone related to alcohol abuse' supported by the sentence: 'CONCLUSION: In patients with septic shock, low-dose hydrocortisone was associated with a lower risk of developing AF during the acute phase.'?","No, it is not directly nor indirectly supported by that sentence, as it does not mention anything about a relationship between hydrocortisone and alcohol abuse." +19531872,Hydrocortisone related to atrial fibrillation,252,"The incidence of psychological symptoms as somatization, obsessive-compulsive symptoms, depression, anxiety, phobia, and nonspecific symptoms is statistically increased in pregnant women with elevated morning cortisol, but in women with elevated afternoon cortisol also occurring aggressiveness and paranoia.",True,"Is the triple 'Hydrocortisone related to atrial fibrillation' supported by the sentence: 'The incidence of psychological symptoms as somatization, obsessive-compulsive symptoms, depression, anxiety, phobia, and nonspecific symptoms is statistically increased in pregnant women with elevated morning cortisol, but in women with elevated afternoon cortisol also occurring aggressiveness and paranoia.'?","Yes, the statement is indirectly supportive because Hydrocortisone is a form of cortisol, a stress hormone produced in the adrenal gland, which is mentioned in relation to psychological symptoms in pregnant women with elevated cortisol levels in the morning in your provided statement. However, it does not directly mention Hydrocortisone in relation to atrial fibrillation, but rather mental health conditions in pregnant women with elevated cortisol levels." +18705900,Hydrocortisone related to phobic disorder,253,How stress gets under the skin: cortisol and stress reactivity in psoriasis.,False,Is the triple 'Hydrocortisone related to phobic disorder' supported by the sentence: 'How stress gets under the skin: cortisol and stress reactivity in psoriasis.'?,"No, this statement does not provide support for a direct or indirect relationship between Hydrocortisone and a phobic disorder. The statement discusses cortisol, a hormone released in response to stress, and its role in psoriasis, a skin condition. Hydrocortisone is a synthetic form of cortisol often used in medication, but there is no mention of a phobic disorder in this context." +15155784,Hydrocortisone related to psoriasis,254,Absorption of hydrocortisone from the skin reservoir in atopic dermatitis.,True,Is the triple 'Hydrocortisone related to psoriasis' supported by the sentence: 'Absorption of hydrocortisone from the skin reservoir in atopic dermatitis.'?,"Yes, it is indirectly supported because absorption of hydrocortisone from the skin can have an impact on conditions like atopic dermatitis, which is often associated with psoriasis. However, it's important to note that this doesn't directly prove a relationship between hydrocortisone and psoriasis, but it does suggest a possible connection worth exploring further." +14891361,"Hydrocortisone related to dermatitis, atopic",255,OBJECTIVE: To assess dexamethasone (DEX) and hydrocortisone (HC) use in premature infants over time and the association of steroid use with the incidence of bronchopulmonary dysplasia (BPD) at 36 weeks' postmenstrual age.,True,"Is the triple 'Hydrocortisone related to dermatitis, atopic' supported by the sentence: 'OBJECTIVE: To assess dexamethasone (DEX) and hydrocortisone (HC) use in premature infants over time and the association of steroid use with the incidence of bronchopulmonary dysplasia (BPD) at 36 weeks' postmenstrual age.'?","Yes, there is an indirect relationship between hydrocortisone and dermatitis, atopic in this context. The reason is that both hydrocortisone (HC) and dexamethasone (DEX) are steroids used in premature infants, as mentioned in the provided sentence. Steroids like these can have side effects on various body systems, including the skin. Dermatitis, including atopic dermatitis, is a known potential side effect of systemic steroid use in infants and children. However, this specific sentence does not directly discuss hydrocortisone's relationship with dermatitis but rather its use in premature infants and its association with bronchopulmonary dysplasia (BPD)." +14483328,Hydrocortisone related to bronchopulmonary dysplasia,256,Increased ratio of mRNA expression of the genes CYP17 and CYP11B1 indicates autonomous cortisol production in adrenocortical tumors.,False,Is the triple 'Hydrocortisone related to bronchopulmonary dysplasia' supported by the sentence: 'Increased ratio of mRNA expression of the genes CYP17 and CYP11B1 indicates autonomous cortisol production in adrenocortical tumors.'?,"No, this statement does not directly support a relationship between Hydrocortisone and bronchopulmonary dysplasia. The statement discusses cortisol production in adrenocortical tumors, but it does not mention Hydrocortisone or its relation to bronchopulmonary dysplasia." +14450267,Hydrocortisone related to adrenal cortex neoplasm,257,"It is concluded that bile acids are potent endogenous inhibitors of 11 beta-HSD and, therefore, could participate in abnormalities of cortisol metabolism observed in liver cirrhosis and extrahepatic biliary obstruction and, possibly, after ingestion of bile acids.",True,"Is the triple 'Hydrocortisone related to adrenal cortex neoplasm' supported by the sentence: 'It is concluded that bile acids are potent endogenous inhibitors of 11 beta-HSD and, therefore, could participate in abnormalities of cortisol metabolism observed in liver cirrhosis and extrahepatic biliary obstruction and, possibly, after ingestion of bile acids.'?","Yes, it's indirectly supported. Hydrocortisone is a type of glucocorticoid, which is produced in the adrenal cortex. The inhibition of 11 beta-HSD, as mentioned in the sentence, could affect the conversion of inactive cortisol to its active form, thereby potentially influencing the function of the adrenal cortex. However, this is a complex physiological process with many factors involved, so it's important to note that this is an indirect relationship." +14387016,Hydrocortisone related to cirrhosis of liver,258,"The plasma cortisol concentration was significantly higher in both DD groups before treatment than in the control group, and it decreased significantly after hoof trimming in the trimmed group.",True,"Is the triple 'Hydrocortisone related to cirrhosis of liver' supported by the sentence: 'The plasma cortisol concentration was significantly higher in both DD groups before treatment than in the control group, and it decreased significantly after hoof trimming in the trimmed group.'?","Yes, it is indirectly supported. Hydrocortisone is a type of corticosteroid, which can affect liver function. The sentence you provided discusses changes in cortisol levels, which is also a type of steroid hormone, in relation to a treatment for hoof trimming in different groups, one of which may have had liver issues (indicated by 'DD groups'). Therefore, there is an indirect connection between hydrocortisone and liver health discussed in this context." +14360687,Hydrocortisone related to dermatitis,259,Hydrocortisone in culture protects the blast cells in acute myeloblastic leukemia from the lethal effects of cytosine arabinoside.,False,Is the triple 'Hydrocortisone related to dermatitis' supported by the sentence: 'Hydrocortisone in culture protects the blast cells in acute myeloblastic leukemia from the lethal effects of cytosine arabinoside.'?,"No, it is not directly supported because acute myeloblastic leukemia is not a skin condition, but a type of blood cancer, so there is no direct connection between hydrocortisone's protective effects on blast cells and dermatitis, which is an inflammatory skin condition." +13844584,Hydrocortisone related to acute myeloid leukemia,260,Continuous subcutaneous hydrocortisone infusion in Addison's disease.,False,Is the triple 'Hydrocortisone related to acute myeloid leukemia' supported by the sentence: 'Continuous subcutaneous hydrocortisone infusion in Addison's disease.'?,"No, there is no direct or indirect mention of a relationship between hydrocortisone and acute myeloid leukemia in this sentence about continuous subcutaneous hydrocortisone infusion in Addison's disease." +13213365,Hydrocortisone related to chronic primary adrenal insufficiency,261,The current findings underline the relevance of cortisol and DHEA assessments and the need for further scrutiny of their interplay to foster our understanding of the biological basis of stress regulation in BPD.,True,Is the triple 'Hydrocortisone related to chronic primary adrenal insufficiency' supported by the sentence: 'The current findings underline the relevance of cortisol and DHEA assessments and the need for further scrutiny of their interplay to foster our understanding of the biological basis of stress regulation in BPD.'?,"Yes, the statement does support a connection between Hydrocortisone (a cortisol preparation) and chronic primary adrenal insufficiency, which is a condition characterized by inadequate production of cortisol, among other hormones, by the adrenal glands. However, it's important to note that this connection is not explicitly stated in the provided sentence, but rather inferred from the context of cortisol assessment's relevance to stress regulation, which is a key aspect of many mental health conditions, including Borderline Personality Disorder (BPD)." +12756660,Hydrocortisone related to borderline personality disorder,262,"This hypoxia-specific increase in surface beta-adrenoreceptors was significantly enhanced in the cortisol-treated erythrocytes, showing that cortisol had a significant impact on erythrocyte beta-adrenoreceptor dynamics in addition to the direct influence of hypoxia.",False,"Is the triple 'Hydrocortisone related to borderline personality disorder' supported by the sentence: 'This hypoxia-specific increase in surface beta-adrenoreceptors was significantly enhanced in the cortisol-treated erythrocytes, showing that cortisol had a significant impact on erythrocyte beta-adrenoreceptor dynamics in addition to the direct influence of hypoxia.'?","No, this statement does not provide support for a relationship between Hydrocortisone (a type of cortisol) and Borderline Personality Disorder (BPD). The statement discusses the impact of cortisol on beta-adrenoreceptor dynamics under hypoxic conditions, but it does not mention BPD or any other mental health condition." +12576998,Hydrocortisone related to Hypoxemia,263,"Congenital adrenal hyperplasia (CAH) due to deficiency of 21-hydroxylase is a disorder of the adrenal cortex characterised by cortisol deficiency, with or without aldosterone deficiency, and androgen excess.",Undefined,"Is the triple 'Hydrocortisone related to Hypoxemia' supported by the sentence: 'Congenital adrenal hyperplasia (CAH) due to deficiency of 21-hydroxylase is a disorder of the adrenal cortex characterised by cortisol deficiency, with or without aldosterone deficiency, and androgen excess.'?","21-hydroxylase is an enzyme involved in the production of cortisol, a hormone that helps regulate metabolism, immune response, and stress response, among other things. In congenital adrenal hyperplasia (CAH) due to deficiency of this enzyme, cortisol production is reduced, which can lead to a compensatory increase in ACTH production, resulting in increased production of other steroid hormones, including androgens. This can lead to various symptoms, including early puberty, rapid growth, and short stature in children, as well as menstrual irregularities, hirsutism, and infertility in adults. + + + + Now, let's connect this with hypoxemia, which is a condition characterized by low levels of oxygen in the blood. Hypoxemia can be caused by various conditions, including respiratory disorders, cardiovascular diseases, and certain medications. + + + + In the context of CAH, hypoxemia is not a direct consequence of cortisol deficiency, aldosterone deficiency, or androgen excess. However, certain complic" +11888652,Hydrocortisone related to congenital adrenal hyperplasia,264,"Changes of smoking behavior and serum adrenocorticotropic hormone, cortisol, prolactin, and endogenous opioids levels in nicotine dependence after naltrexone treatment.",False,"Is the triple 'Hydrocortisone related to congenital adrenal hyperplasia' supported by the sentence: 'Changes of smoking behavior and serum adrenocorticotropic hormone, cortisol, prolactin, and endogenous opioids levels in nicotine dependence after naltrexone treatment.'?","No, that sentence does not provide any direct or indirect support for a relationship between Hydrocortisone and congenital adrenal hyperplasia. It discusses changes in hormone levels in relation to nicotine dependence and naltrexone treatment, but it does not mention Hydrocortisone or congenital adrenal hyperplasia." +11866289,Hydrocortisone related to nicotine dependence,265,We hypothesize that hydrocortisone infusion in severe community-acquired pneumonia attenuates systemic inflammation and leads to earlier resolution of pneumonia and a reduction in sepsis-related complications.,False,Is the triple 'Hydrocortisone related to nicotine dependence' supported by the sentence: 'We hypothesize that hydrocortisone infusion in severe community-acquired pneumonia attenuates systemic inflammation and leads to earlier resolution of pneumonia and a reduction in sepsis-related complications.'?,"No, the statement does not provide any information about a relationship between Hydrocortisone and nicotine dependence. It discusses the potential effects of Hydrocortisone on inflammation and pneumonia resolution in severe community-acquired pneumonia patients, but it does not mention or imply a connection with nicotine use or dependence." +11530989,Hydrocortisone related to pneumonia,266,A prospective study was performed to investigate the combination of the aromatase inhibitor aminoglutethimide and hydrocortisone in androgen-independent prostate cancer with changes in prostate-specific antigen (PSA) level as main determinant for response.,False,Is the triple 'Hydrocortisone related to pneumonia' supported by the sentence: 'A prospective study was performed to investigate the combination of the aromatase inhibitor aminoglutethimide and hydrocortisone in androgen-independent prostate cancer with changes in prostate-specific antigen (PSA) level as main determinant for response.'?,"No, this statement does not provide any information about a relationship between hydrocortisone and pneumonia, directly or indirectly. It discusses a study involving hydrocortisone in prostate cancer treatment, focusing on changes in prostate-specific antigen levels as a response indicator." +11442939,Hydrocortisone related to prostate cancer,267,"To investigate the time courses of the effects of the exogenous glucocorticoid agonists dexamethasone (DEX) and hydrocortisone (HYD) and a glucocorticoid antagonist (RU-38486), and to characterize the local and systemic responses in experimental AP.",False,"Is the triple 'Hydrocortisone related to prostate cancer' supported by the sentence: 'To investigate the time courses of the effects of the exogenous glucocorticoid agonists dexamethasone (DEX) and hydrocortisone (HYD) and a glucocorticoid antagonist (RU-38486), and to characterize the local and systemic responses in experimental AP.'?","No, this sentence does not provide any direct or indirect support for a relationship between hydrocortisone and prostate cancer. The sentence discusses an investigation into the effects of exogenous glucocorticoid agonists, including dexamethasone (DEX) and hydrocortisone (HYD), as well as a glucocorticoid antagonist (RU-38486), in an experimental setting, but it does not mention anything about prostate cancer." +11089023,Hydrocortisone related to pancreatitis,268,[The adrenal cortex and hydrocortisone metabolism in experimental myocardial infarct].,False,Is the triple 'Hydrocortisone related to pancreatitis' supported by the sentence: '[The adrenal cortex and hydrocortisone metabolism in experimental myocardial infarct].'?,"No, the sentence does not provide any information that directly or indirectly supports a relationship between Hydrocortisone and pancreatitis. The title discusses the adrenal cortex and hydrocortisone metabolism in experimental myocardial infarct, which is not related to pancreatitis." +10649902,Hydrocortisone related to myocardial infarction,269,[Intraarticular hydrocortisone (cortril) in arthritis and osteoarthritis].,False,Is the triple 'Hydrocortisone related to myocardial infarction' supported by the sentence: '[Intraarticular hydrocortisone (cortril) in arthritis and osteoarthritis].'?,"No, the provided sentence does not support a direct or indirect relationship between Hydrocortisone and myocardial infarction. The sentence mentions the use of Hydrocortisone (under the brand name Cortril) in arthritis and osteoarthritis, but it does not mention or imply any connection to myocardial infarction." +10522181,Hydrocortisone related to osteoarthritis,270,[Use of cortisone and hydrocortisone in eye diseases].,False,Is the triple 'Hydrocortisone related to osteoarthritis' supported by the sentence: '[Use of cortisone and hydrocortisone in eye diseases].'?,"No, this statement does not provide direct or indirect support for a relationship between hydrocortisone and osteoarthritis, as it discusses the use of these substances in eye diseases, not in joint diseases like osteoarthritis." +10521296,Hydrocortisone related to eye disorder,271,[Topical use of hydrocortisone in otitis externa].,False,Is the triple 'Hydrocortisone related to eye disorder' supported by the sentence: '[Topical use of hydrocortisone in otitis externa].'?,"No, it is not directly nor indirectly supported because there is no mentioning of any relation between topical use of hydrocortisone in otitis externa (outer ear infection) and an eye disorder in that statement." +10518203,Hydrocortisone related to otitis externa,272,The use of hydrocortisone in ulcerative colitis: preliminary observations.,False,Is the triple 'Hydrocortisone related to otitis externa' supported by the sentence: 'The use of hydrocortisone in ulcerative colitis: preliminary observations.'?,"No, that statement does not provide any direct or indirect support for a relationship between Hydrocortisone and otitis externa. It discusses the use of Hydrocortisone in ulcerative colitis, not in relation to ear infections or otitis externa." +10484611,Hydrocortisone related to ulcerative colitis,273,It can therefore be concluded that ointments containing either only E. coli BCS or a combination of BCS and hydrocortisone provide significant relief in perianal eczema as well as in early stages of hemorrhoidal disease.,True,Is the triple 'Hydrocortisone related to ulcerative colitis' supported by the sentence: 'It can therefore be concluded that ointments containing either only E. coli BCS or a combination of BCS and hydrocortisone provide significant relief in perianal eczema as well as in early stages of hemorrhoidal disease.'?,"Yes, it is indirectly supported because hydrocortisone is mentioned in a medical context, but it does not specifically state a relationship between hydrocortisone and ulcerative colitis in this sentence." +9718673,Hydrocortisone related to atopic eczema,274,The effect on cortisol supports the above conclusion and is consistent with HPA axis perturbation in opioid dependence as reported in other studies and extends these observations to stable methadone-maintained patients.,True,Is the triple 'Hydrocortisone related to atopic eczema' supported by the sentence: 'The effect on cortisol supports the above conclusion and is consistent with HPA axis perturbation in opioid dependence as reported in other studies and extends these observations to stable methadone-maintained patients.'?,"Yes, it is indirectly supported. The mentioned study reports perturbations in HPA axis, which is responsible for producing cortisol, in opioid dependence, extending this observation to stable methadone-maintained patients, which is a form of treatment for opioid dependence, like hydrocortisone, a medication used for treating various conditions, including atopic eczema. This shared context of HPA axis perturbation in opioid dependence may imply a connection between hydrocortisone use and atopic eczema, but it does not provide direct evidence of a relationship between hydrocortisone and atopic eczema." +9492934,Hydrocortisone related to opiate dependence,275,Several randomized controlled trials have evaluated the efficacy of a replacement therapy with hydrocortisone in severe sepsis.,False,Is the triple 'Hydrocortisone related to opiate dependence' supported by the sentence: 'Several randomized controlled trials have evaluated the efficacy of a replacement therapy with hydrocortisone in severe sepsis.'?,"No, there is no direct mention of hydrocortisone's relation to opiate dependence in this sentence. This statement discusses hydrocortisone's use in replacement therapy for severe sepsis, not its potential connection with opiate dependence." +9238280,Hydrocortisone related to Sepsis,276,[Diurnal variations in blood glucose and plasma cortisol in juvenile diabetes mellitus without ketoacidosis].,Undefined,Is the triple 'Hydrocortisone related to Sepsis' supported by the sentence: '[Diurnal variations in blood glucose and plasma cortisol in juvenile diabetes mellitus without ketoacidosis].'?,"The provided document appears to discuss diurnal (daily) fluctuations of cortisol (a hormone) and blood sugar levels in juvenile diabetes without ketoacidosis, a serious complication of diabetes. It does not directly mention sepsis, which is a severe infection causing inflammation throughout the body, nor does it discuss hydrocortisone, a medication used to treat various conditions, including adrenal insufficiency, allergies, and skin conditions. Therefore, I cannot confirm a direct relationship between hydrocortisone, sepsis, and this study on diurnal fluctuations of cortisol and blood sugar levels in diabetes patients." +9235597,Hydrocortisone related to type 1 diabetes mellitus,277,"OBJECTIVES: Elderly women with proximal femur fracture show abnormal persistence of increased cortisol concentrations, which could contribute to the high morbidity associated with this injury.",True,"Is the triple 'Hydrocortisone related to type 1 diabetes mellitus' supported by the sentence: 'OBJECTIVES: Elderly women with proximal femur fracture show abnormal persistence of increased cortisol concentrations, which could contribute to the high morbidity associated with this injury.'?","Yes, it is indirectly supported. The statement mentions an abnormal persistence of increased cortisol concentrations in elderly women with proximal femur fracture, which could contribute to high morbidity. Hydrocortisone is a type of corticosteroid, which can increase cortisol levels in the body. Therefore, if a patient with type 1 diabetes mellitus was given Hydrocortisone, it could potentially lead to abnormal cortisol levels, similar to what is described in the statement, which could contribute to morbidity. However, this is a very indirect link and further research would be needed to confirm this relationship." +8977987,Hydrocortisone related to injury,278,"From the compendium presented above, the following statements become evident: 1) Inappropriately low secretion of cortisol in relation to inflammation is a typical feature of the inflammatory disease in patients with RA.",True,"Is the triple 'Hydrocortisone related to injury' supported by the sentence: 'From the compendium presented above, the following statements become evident: 1) Inappropriately low secretion of cortisol in relation to inflammation is a typical feature of the inflammatory disease in patients with RA.'?","Yes, it is indirectly supported. The statement suggests that inappropriately low secretion of cortisol (a stress hormone) is associated with inflammation in patients with rheumatoid arthritis (RA). Hydrocortisone is a synthetic form of cortisol often used in medical treatments for its anti-inflammatory effects. Therefore, a lack of cortisol could potentially lead to increased inflammation, which is relevant to injury. However, this is a complex topic with many factors at play, so it's always best to consult with a healthcare professional for specific medical advice." +8778414,Hydrocortisone related to Inflammation,279,Hydrocortisone infusion in septic shock differentially regulated the cytokine responses.,True,Is the triple 'Hydrocortisone related to Inflammation' supported by the sentence: 'Hydrocortisone infusion in septic shock differentially regulated the cytokine responses.'?,"Yes, it is. The statement suggests that Hydrocortisone, a type of steroid hormone, can influence cytokine responses in septic shock, which is a state of severe inflammation. Therefore, there is an indirect relationship between Hydrocortisone and inflammation as described in the sentence." +8763179,Hydrocortisone related to toxic shock syndrome,280,"BACKGROUND: There is substantial evidence of dysregulation of cortisol secretion, hippocampal abnormalities, and memory deficits in schizophrenia and other psychotic disorders.",False,"Is the triple 'Hydrocortisone related to toxic shock syndrome' supported by the sentence: 'BACKGROUND: There is substantial evidence of dysregulation of cortisol secretion, hippocampal abnormalities, and memory deficits in schizophrenia and other psychotic disorders.'?","No, there is no direct mention or indication in this statement about Hydrocortisone being related to Toxic Shock Syndrome (TSS). The statement discusses cortisol secretion, hippocampal abnormalities, memory deficits in schizophrenia, and other psychotic disorders, but it does not connect these topics directly with Hydrocortisone nor TSS." +8625521,Hydrocortisone related to dissociative amnesia,281,(2) One of the mechanisms of therapeutic effect of cortisol in asthma might be its inhibitory effect on CA uptake.,False,Is the triple 'Hydrocortisone related to dissociative amnesia' supported by the sentence: '(2) One of the mechanisms of therapeutic effect of cortisol in asthma might be its inhibitory effect on CA uptake.'?,"No, it is not directly or indirectly supported because there is no mention in that statement about Hydrocortisone, which is a specific type of corticosteroid, nor is there any mention about dissociative amnesia. The statement talks about cortisol's potential inhibitory effect on CA uptake in asthma, which is a different context from what you've asked about." +8615164,Hydrocortisone related to asthma,282,"OBJECTIVE: To compare cortisol levels, diurnal cycles of cortisol, and reactivity of cortisol to psychological stress in fibromyalgia (FM) and rheumatoid arthritis (RA) patients in their natural environment, and to examine the effect on results of accounting for differences among the groups in psychological stress and other lifestyle and psychosocial variables.",True,"Is the triple 'Hydrocortisone related to asthma' supported by the sentence: 'OBJECTIVE: To compare cortisol levels, diurnal cycles of cortisol, and reactivity of cortisol to psychological stress in fibromyalgia (FM) and rheumatoid arthritis (RA) patients in their natural environment, and to examine the effect on results of accounting for differences among the groups in psychological stress and other lifestyle and psychosocial variables.'?","Yes, it is indirectly supported. Hydrocortisone is a synthetic form of cortisol, a hormone produced by the adrenal gland in response to stress. The sentence discusses comparing cortisol levels, diurnal cycles of cortisol, and reactivity of cortisol to psychological stress in fibromyalgia (FM) and rheumatoid arthritis (RA) patients, which implies a relationship between these conditions, stress, and cortisol, thus also implying a relationship with hydrocortisone as a synthetic form of cortisol." +8570630,Hydrocortisone related to fibromyalgia,283,"OBJECTIVES: Recent data suggest that higher plasma cortisol may be associated with hypertension and insulin resistance in otherwise healthy men, as it is in Cushing's syndrome.",True,"Is the triple 'Hydrocortisone related to fibromyalgia' supported by the sentence: 'OBJECTIVES: Recent data suggest that higher plasma cortisol may be associated with hypertension and insulin resistance in otherwise healthy men, as it is in Cushing's syndrome.'?","Yes, it is indirectly supported because Hydrocortisone is a type of corticosteroid, which can increase cortisol levels in the body, similar to what occurs in Cushing's syndrome. Fibromyalgia has been associated with cortisol dysregulation, which could potentially be linked to hypertension and insulin resistance, as suggested in the given statement about otherwise healthy men with higher plasma cortisol levels. However, this is a complex relationship with many variables, so further research would be needed for a definitive conclusion." +8017438,Hydrocortisone related to Insulin resistance,284,"These findings demonstrate 2 types of adrenal insufficiency with different clinical pictures: Type 1 is characterized by cortisol deficiency with hypoglycaemia, low corticoid levels and a low cortisol secretion rate; Type 2 shows aldosterone deficiency with prominent salt loss.",True,"Is the triple 'Hydrocortisone related to Insulin resistance' supported by the sentence: 'These findings demonstrate 2 types of adrenal insufficiency with different clinical pictures: Type 1 is characterized by cortisol deficiency with hypoglycaemia, low corticoid levels and a low cortisol secretion rate; Type 2 shows aldosterone deficiency with prominent salt loss.'?","Yes, it is indirectly supported because Hydrocortisone is a type of corticosteroid, and corticosteroids play a role in glucose metabolism, which is relevant to insulin resistance. However, the given sentence does not directly mention Hydrocortisone, Insulin, or Resistance, so it's an indirect association based on the broader context of corticosteroids and glucose metabolism." +7919367,Hydrocortisone related to adrenocortical insufficiency,285,"November, a period of reproductive quiescence in the southern hemisphere, with new antler growth and rapid weight gain, is associated with higher mean plasma cortisol concentrations and a greater responsiveness to exogenous ACTH.",True,"Is the triple 'Hydrocortisone related to adrenocortical insufficiency' supported by the sentence: 'November, a period of reproductive quiescence in the southern hemisphere, with new antler growth and rapid weight gain, is associated with higher mean plasma cortisol concentrations and a greater responsiveness to exogenous ACTH.'?","Yes, it is indirectly supported. Hydrocortisone is a type of corticosteroid that is often used to treat conditions related to the adrenal gland such as adrenocortical insufficiency. The sentence you provided mentions higher mean plasma cortisol concentrations and a greater responsiveness to exogenous ACTH during November in the southern hemisphere. Cortisol is a hormone produced by the adrenal gland in response to stress, including physical stress such as new antler growth and rapid weight gain. Therefore, higher cortisol levels could indicate a more active adrenal gland, which is relevant to conditions like adrenocortical insufficiency where the adrenal gland is not functioning properly. However, this is an indirect correlation as it doesn't directly mention Hydrocortisone or adrenocortical insufficiency." +7573954,Hydrocortisone related to neoplasm,286,Cortisol metabolism in human obesity: impaired cortisone-->cortisol conversion in subjects with central adiposity.,False,Is the triple 'Hydrocortisone related to neoplasm' supported by the sentence: 'Cortisol metabolism in human obesity: impaired cortisone-->cortisol conversion in subjects with central adiposity.'?,"No, the mentioned sentence does not provide a direct or indirect support for a relationship between Hydrocortisone (a form of Cortisol) and neoplasm (new abnormal growth of tissue). The sentence discusses cortisol metabolism, specifically impaired cortisone-to-cortisol conversion, in relation to obesity with central adiposity (excess fat around internal organs)." +7182905,Hydrocortisone related to obesity disorder,287,The hypothalamic-pituitary-adrenal (HPA) axis is one of the key physiological systems that counterbalances this systemic inflammation through changes in adrenocorticotrophic hormone (ACTH) and cortisol.,True,Is the triple 'Hydrocortisone related to obesity disorder' supported by the sentence: 'The hypothalamic-pituitary-adrenal (HPA) axis is one of the key physiological systems that counterbalances this systemic inflammation through changes in adrenocorticotrophic hormone (ACTH) and cortisol.'?,"Yes, there is an indirect relationship between Hydrocortisone and obesity disorder as per the given sentence. Hydrocortisone is a type of corticosteroid, which is released by the adrenal gland in response to adrenocorticotrophic hormone (ACTH) stimulation from the pituitary gland, as part of the HPA axis. Systemic inflammation can impact the HPA axis, leading to changes in ACTH and cortisol levels, which in turn can contribute to metabolic disorders such as obesity due to cortisol's role in fat distribution, appetite regulation, and glucose metabolism. However, this is a complex process with multiple factors involved, so further research is required to fully understand the relationship between HPA axis dysregulation, Hydrocortisone, and obesity." +24445107,Hydrocortisone related to Inflammation,288,"The 5 dpf hypoxic exposure also elicited transient increases in whole body cortisol and in crf, uts1, and hsd20b2 expression, key regulators of the endocrine stress response.",True,"Is the triple 'Hydrocortisone related to Inflammation' supported by the sentence: 'The 5 dpf hypoxic exposure also elicited transient increases in whole body cortisol and in crf, uts1, and hsd20b2 expression, key regulators of the endocrine stress response.'?","Yes, it is indirectly supported. The mention of cortisol, a key regulator of the endocrine stress response, in relation to a hypoxic exposure that elicits an increase in cortisol levels suggests a connection to inflammation. Cortisol is known to have anti-inflammatory effects in the body, so an increase in cortisol could be a response to manage inflammation. However, this is an inference and not explicitly stated in the provided sentence." +24030854,Hydrocortisone related to Hypoxemia,289,"At multiple regression analyses, HOMA-IR on admission in the IR group significantly correlated with thyroid-stimulating hormone, glucagon, and cortisol.",True,"Is the triple 'Hydrocortisone related to Hypoxemia' supported by the sentence: 'At multiple regression analyses, HOMA-IR on admission in the IR group significantly correlated with thyroid-stimulating hormone, glucagon, and cortisol.'?","Yes, there is an indirect relationship between hydrocortisone and hypoxemia in this context. The sentence you provided mentions a correlation between cortisol (a hormone produced in response to stress, which hydrocortisone is a synthetic form of) with HOMA-IR (Homeostatic Model Assessment for Insulin Resistance) on admission in a group with insulin resistance (IR). Insulin resistance is a risk factor for hypoxemia (low oxygen levels in the blood). Therefore, there is an indirect relationship between hydrocortisone (used as a treatment for various conditions) and hypoxemia through insulin resistance. However, it is essential to note that this relationship is not direct but rather mediated through other factors such as insulin resistance." +12533519,Hydrocortisone related to Insulin resistance,290,"The suppression of the anti-inflammatory effects of cortisol as a result of states of excessive stress leads to hypercatabolic diseases such as AIDS, sepsis and toxic shock syndrome and protein calorie malnutrition (NAIDS).",True,"Is the triple 'Hydrocortisone related to Insulin resistance' supported by the sentence: 'The suppression of the anti-inflammatory effects of cortisol as a result of states of excessive stress leads to hypercatabolic diseases such as AIDS, sepsis and toxic shock syndrome and protein calorie malnutrition (NAIDS).'?","Yes, there is an indirect relationship between Hydrocortisone and Insulin resistance based on the provided sentence. Hydrocortisone, a type of corticosteroid, has anti-inflammatory effects, which can be suppressed due to excessive stress, leading to hypercatabolic diseases such as AIDS, sepsis, toxic shock syndrome, and protein calorie malnutrition (NAIDS). These conditions can cause metabolic changes that may contribute to insulin resistance, hence the connection between Hydrocortisone and insulin resistance is established, albeit indirectly through these disease states." +27747116,Hydrocortisone causes toxic shock syndrome,291,"The suppression of the anti-inflammatory effects of cortisol as a result of states of excessive stress leads to hypercatabolic diseases such as AIDS, sepsis and toxic shock syndrome and protein calorie malnutrition (NAIDS).",False,"Is the triple 'Hydrocortisone causes toxic shock syndrome' supported by the sentence: 'The suppression of the anti-inflammatory effects of cortisol as a result of states of excessive stress leads to hypercatabolic diseases such as AIDS, sepsis and toxic shock syndrome and protein calorie malnutrition (NAIDS).'?","No, this statement does not directly support the claim that hydrocortisone, a synthetic form of cortisol, causes toxic shock syndrome. The statement discusses the consequences of the suppression of cortisol's anti-inflammatory effects, not specifically the administration of hydrocortisone." +27747115,Hydrocortisone causes Sepsis,292,"We report the case of a 41-year-old nonatopic women with a previous history of eczematous reaction due to hydrocortisone who suffered worsening of her perennial rhinitis in association with perinasal dermatitis from the use of budesonide in nasal spray form, and stomatitis and pharyngitis due to budesonide in a bronchial inhaler.",False,"Is the triple 'Hydrocortisone causes Sepsis' supported by the sentence: 'We report the case of a 41-year-old nonatopic women with a previous history of eczematous reaction due to hydrocortisone who suffered worsening of her perennial rhinitis in association with perinasal dermatitis from the use of budesonide in nasal spray form, and stomatitis and pharyngitis due to budesonide in a bronchial inhaler.'?","No, this statement does not provide evidence that hydrocortisone directly or indirectly causes sepsis. It discusses an individual's adverse reactions to budesonide, not hydrocortisone, and does not mention sepsis." +27073884,Hydrocortisone causes atopic eczema,293,"In this perspective paper, we focus on the neuro-endocrine interactions that occur between progesterone, allopregnanolone, and cortisol during pregnancy, and propose that they align with our previously proposed model of FM pathogenesis based on GABAergic ""weakening"" in a thalamocortical neural loop system.",False,"Is the triple 'Hydrocortisone causes atopic eczema' supported by the sentence: 'In this perspective paper, we focus on the neuro-endocrine interactions that occur between progesterone, allopregnanolone, and cortisol during pregnancy, and propose that they align with our previously proposed model of FM pathogenesis based on GABAergic ""weakening"" in a thalamocortical neural loop system.'?","No, it is not directly nor indirectly supported by that sentence. The statement talks about progesterone, allopregnanolone, and cortisol during pregnancy and their potential interactions with GABAergic systems in a thalamocortical neural loop system. It does not mention hydrocortisone or atopic eczema." +25383174,Hydrocortisone causes fibromyalgia,294,The present study reported a case of hydrocortisone-induced blood pressure reduction in a patient with anterior pituitary hypofunction due to allergic reaction.,False,Is the triple 'Hydrocortisone causes fibromyalgia' supported by the sentence: 'The present study reported a case of hydrocortisone-induced blood pressure reduction in a patient with anterior pituitary hypofunction due to allergic reaction.'?,"No, this statement does not provide any support for the idea that Hydrocortisone causes fibromyalgia, directly or indirectly. It discusses an allergic reaction that led to anterior pituitary hypofunction and blood pressure reduction in response to Hydrocortisone, but it does not mention anything about fibromyalgia." +25205462,Hydrocortisone causes hypotensive disorder,295,Fetal adrenocorticotropic hormone and cortisol increased to peak values within 2.8 hours of induced hypoxia but by 7.2 hours had begun to fall to values that were not significantly different from those at 1.4 hours.,False,Is the triple 'Hydrocortisone causes hypotensive disorder' supported by the sentence: 'Fetal adrenocorticotropic hormone and cortisol increased to peak values within 2.8 hours of induced hypoxia but by 7.2 hours had begun to fall to values that were not significantly different from those at 1.4 hours.'?,"No, this statement does not support the claim that Hydrocortisone causes hypotensive disorder. The statement discusses the effects of induced hypoxia on fetal adrenocorticotropic hormone and cortisol levels, but it does not mention Hydrocortisone or any hypotensive disorders." +20591759,Hydrocortisone causes Hypoxemia,296,Congenital adrenal hyperplasia (CAH) is a chronic condition and individuals are exposed to elevated androgen levels in utero as a result of the endogenous cortisol deficiency.,True,Is the triple 'Hydrocortisone causes Hypoxemia' supported by the sentence: 'Congenital adrenal hyperplasia (CAH) is a chronic condition and individuals are exposed to elevated androgen levels in utero as a result of the endogenous cortisol deficiency.'?,"Yes, there is an indirect connection between these two statements. Congenital Adrenal Hyperplasia (CAH) is a chronic condition where individuals have a deficiency in cortisol, leading to elevated levels of androgens in utero. Hydrocortisone is a medication often used to treat CAH, as it helps to replace the missing cortisol. If not treated, CAH can lead to a number of complications, one of which is hypoxemia, or low oxygen levels in the blood, due to issues with lung development. Therefore, while hydrocortisone itself does not cause hypoxemia, its use in treating CAH can help prevent this complication." +18446972,Hydrocortisone causes congenital adrenal hyperplasia,297,The results of our study confirm that thymol has strong ameliorative effect against hydrocortisone-induced oxidative stress injury in hepatic tissues.,False,Is the triple 'Hydrocortisone causes congenital adrenal hyperplasia' supported by the sentence: 'The results of our study confirm that thymol has strong ameliorative effect against hydrocortisone-induced oxidative stress injury in hepatic tissues.'?,"No, it is not directly or indirectly supported. The study investigates thymol's effect against hydrocortisone-induced oxidative stress injury in hepatic tissues, not its impact on congenital adrenal hyperplasia." +18240145,Hydrocortisone causes injury,298,The effects of 8-bromo-cyclic AMP and cyclic AMP agonists (cholera toxin plus hydrocortisone and prostaglandin E2 plus 3-isobutyl-1-methylxanthine) on the cytotoxic activity of T cells generated during murine influenza virus infection have been examined.,False,Is the triple 'Hydrocortisone causes injury' supported by the sentence: 'The effects of 8-bromo-cyclic AMP and cyclic AMP agonists (cholera toxin plus hydrocortisone and prostaglandin E2 plus 3-isobutyl-1-methylxanthine) on the cytotoxic activity of T cells generated during murine influenza virus infection have been examined.'?,"No, it is not directly nor indirectly supported, as this statement does not imply any harm caused by hydrocortisone, but rather it mentions hydrocortisone as a component in an experiment that examines T cell cytotoxicity during murine influenza virus infection, along with other substances like cyclic AMP agonists, cholera toxin, prostaglandin E2, and 3-isobutyl-1-methylxanthine." +17359303,Hydrocortisone causes influenza,299,Open oral provocation with 100 or 250 mg hydrocortisone in patients with hydrocortisone contact hypersensitivity elicited cutaneous reactions at sites of previous allergic dermatitis caused by hydrocortisone in two patients and at sites of earlier allergic patch test reactions caused by hydrocortisone in the other two patients.,False,Is the triple 'Hydrocortisone causes influenza' supported by the sentence: 'Open oral provocation with 100 or 250 mg hydrocortisone in patients with hydrocortisone contact hypersensitivity elicited cutaneous reactions at sites of previous allergic dermatitis caused by hydrocortisone in two patients and at sites of earlier allergic patch test reactions caused by hydrocortisone in the other two patients.'?,"No, this statement does not support the claim that hydrocortisone causes influenza. It suggests that hydrocortisone can cause allergic reactions in certain patients, but it does not link it to the development of influenza." +13585273,"Hydrocortisone causes dermatitis, atopic",300,"Although initial studies in transgenic mice and humans are encouraging, more data are required to conclusively prove the hypothesis that the adipose-tissue-specific overexpression of HSD1 and the resultant increase in tissue-specific cortisol concentrations result in human obesity, insulin resistance, high blood pressure, and metabolic syndrome.",False,"Is the triple 'Hydrocortisone causes dermatitis, atopic' supported by the sentence: 'Although initial studies in transgenic mice and humans are encouraging, more data are required to conclusively prove the hypothesis that the adipose-tissue-specific overexpression of HSD1 and the resultant increase in tissue-specific cortisol concentrations result in human obesity, insulin resistance, high blood pressure, and metabolic syndrome.'?","No, it is not directly related because it discusses obesity, insulin resistance, high blood pressure, and metabolic syndrome caused by adipose-tissue-specific overexpression of HSD1 and increased tissue-specific cortisol concentrations, not hydrocortisone-induced dermatitis." +12645476,Hydrocortisone causes obesity disorder,301,"CONCLUSION: Although hydrocortisone has anti-inflammatory properties, it seems to provoke inflammation in the round window membrane after topical instillation.",False,"Is the triple 'Hydrocortisone causes obesity disorder' supported by the sentence: 'CONCLUSION: Although hydrocortisone has anti-inflammatory properties, it seems to provoke inflammation in the round window membrane after topical instillation.'?","No, it is not directly or indirectly supported, as there is no mention of obesity or any related disorders in this conclusion statement, nor any indication of a causal relationship between hydrocortisone use, inflammation, and obesity disorders in topical instillation cases." +10068843,Hydrocortisone causes Inflammation,302,"Type 2 glucocorticoid receptors (GRs), which are occupied by cortisol in humans in times of stress, are thought to be responsible for the glucocorticoid-induced memory impairment.",False,"Is the triple 'Hydrocortisone causes Inflammation' supported by the sentence: 'Type 2 glucocorticoid receptors (GRs), which are occupied by cortisol in humans in times of stress, are thought to be responsible for the glucocorticoid-induced memory impairment.'?","No, this statement does not support the idea that Hydrocortisone, a type of glucocorticoid, causes inflammation. Instead, it discusses the role of Type 2 glucocorticoid receptors in memory impairment, not inflammation." +9850315,Hydrocortisone causes dissociative amnesia,303,"Firstly, the GH-mediated increase in cortisol metabolism (mediated via reduced E to F conversion) may precipitate adrenal insufficiency in hypopituitary patients with partial adrenocorticotropic hormone deficiency commencing GH therapy.",False,"Is the triple 'Hydrocortisone causes dissociative amnesia' supported by the sentence: 'Firstly, the GH-mediated increase in cortisol metabolism (mediated via reduced E to F conversion) may precipitate adrenal insufficiency in hypopituitary patients with partial adrenocorticotropic hormone deficiency commencing GH therapy.'?","No, it is not directly or indirectly supported by that sentence. The statement concerns a potential mechanism for adrenal insufficiency in patients with partial adrenocorticotropic hormone deficiency undergoing growth hormone therapy due to an alteration in cortisol metabolism, not a causal link to dissociative amnesia related to hydrocortisone use." +9318796,Hydrocortisone causes adrenocortical insufficiency,304,"From this study it is inferred that the group III steroid betamethasone dipropionate alone heals experimentally induced external otitis more rapidly than hydrocortisone with oxytetracycline, with or without polymyxin B.",False,"Is the triple 'Hydrocortisone causes adrenocortical insufficiency' supported by the sentence: 'From this study it is inferred that the group III steroid betamethasone dipropionate alone heals experimentally induced external otitis more rapidly than hydrocortisone with oxytetracycline, with or without polymyxin B.'?","No, because this statement does not suggest any relationship between hydrocortisone and adrenocortical insufficiency, but rather compares the healing effects of two different steroids in treating external otitis." +9145908,Hydrocortisone causes otitis externa,305,"In conclusion, the reciprocal expression of CYP17 and the transcriptional repressors COUP-TF and DAX-1 indicates that these orphan receptors have a pathophysiologic role in the excessive hormone production in cortisol- and deoxycorticosterone-producing adrenocortical tumors.",False,"Is the triple 'Hydrocortisone causes otitis externa' supported by the sentence: 'In conclusion, the reciprocal expression of CYP17 and the transcriptional repressors COUP-TF and DAX-1 indicates that these orphan receptors have a pathophysiologic role in the excessive hormone production in cortisol- and deoxycorticosterone-producing adrenocortical tumors.'?",No. The statement does not provide any direct or indirect support for a link between Hydrocortisone and otitis externa. It discusses the role of certain orphan receptors in excessive hormone production in adrenocortical tumors. +8699464,Hydrocortisone causes adrenal cortex neoplasm,306,"The administration of hydrocortisone before tumor inoculation resulted in increased tumor take, reduced mean survival time of mice, and concentration of tumor metastasis in a specific organ (i.e., lung metastasis for Ehrlich hypotetraploid clone 1 tumor, and liver metastasis for Ehrlich hypotetraploid stock and Ehrlich hyperdiploid stock tumors).",True,"Is the triple 'Hydrocortisone causes adrenal cortex neoplasm' supported by the sentence: 'The administration of hydrocortisone before tumor inoculation resulted in increased tumor take, reduced mean survival time of mice, and concentration of tumor metastasis in a specific organ (i.e., lung metastasis for Ehrlich hypotetraploid clone 1 tumor, and liver metastasis for Ehrlich hypotetraploid stock and Ehrlich hyperdiploid stock tumors).'?","Yes, it is indirectly supported. The provided sentence suggests that administering hydrocortisone can influence tumor growth, survival time, and metastasis concentration in specific organs, which could potentially be linked to changes in the adrenal cortex, although it does not explicitly state this relationship." +8657746,Hydrocortisone causes neoplasm,307,"Cortisol counteracts the insulin activation of glycogen synthase in muscle, the insulin inhibition of hepatic glucose production and the insulin inhibition of lipolysis in adipose tissue, leading to the well-established systemic insulin resistance caused by excess cortisol.",False,"Is the triple 'Hydrocortisone causes neoplasm' supported by the sentence: 'Cortisol counteracts the insulin activation of glycogen synthase in muscle, the insulin inhibition of hepatic glucose production and the insulin inhibition of lipolysis in adipose tissue, leading to the well-established systemic insulin resistance caused by excess cortisol.'?","No, the statement does not support a direct link between Hydrocortisone (a form of cortisol) and neoplasm (abnormal tissue growth). The provided sentence discusses the metabolic effects of cortisol, not its potential carcinogenic effects." +7929803,Hydrocortisone causes Insulin resistance,308,"The amount of N-acetyl D-glucosamine in the zymogen granule membrane was not altered by caerulein acute pancreatitis induced under continuous hydrocortisone treatment, but it was decreased by the administration of L-364,718 over 7 days after pancreatitis induction.",True,"Is the triple 'Hydrocortisone causes Insulin resistance' supported by the sentence: 'The amount of N-acetyl D-glucosamine in the zymogen granule membrane was not altered by caerulein acute pancreatitis induced under continuous hydrocortisone treatment, but it was decreased by the administration of L-364,718 over 7 days after pancreatitis induction.'?","Yes, it is indirectly supported because both Hydrocortisone and L-364,718 affect glucose metabolism, with Hydrocortisone potentially causing insulin resistance, as suggested in your first statement, and L-364,718 having a different effect that suggests a different impact on insulin sensitivity, as suggested in your second statement." +7432490,Hydrocortisone causes pancreatitis,309,False elevation of plasma cortisol in congenital adrenal hyperplasia.,False,Is the triple 'Hydrocortisone causes pancreatitis' supported by the sentence: 'False elevation of plasma cortisol in congenital adrenal hyperplasia.'?,"No, it is not directly supported because congenital adrenal hyperplasia is a genetic disorder that leads to a deficiency in certain enzymes needed to make cortisol, not an excess as might be caused by hydrocortisone use. However, one could argue that any abnormality in cortisol levels, whether too high or too low, could potentially have impacts on other organs, such as the pancreas, but this would be a very indirect connection." +26997315,Hydrocortisone affects congenital adrenal hyperplasia,310,Further studies evaluating the mechanism of action and long term effects of hydrocortisone in cardiac arrest need to be conducted.,False,Is the triple 'Hydrocortisone affects congenital adrenal hyperplasia' supported by the sentence: 'Further studies evaluating the mechanism of action and long term effects of hydrocortisone in cardiac arrest need to be conducted.'?,"No, it is not directly supported because there is no explicit mention of congenital adrenal hyperplasia in the given sentence. The focus is on further investigating hydrocortisone's mechanism of action and long-term effects in cardiac arrest, not in relation to congenital adrenal hyperplasia." +26940919,Hydrocortisone affects cardiac arrest,311,"In acute MI, there were elevated plasma levels of cortisol depending on the MI severity with a small repeated peak of its increase on day 14 and its subsequent decrease, except deaths.",True,"Is the triple 'Hydrocortisone affects cardiac arrest' supported by the sentence: 'In acute MI, there were elevated plasma levels of cortisol depending on the MI severity with a small repeated peak of its increase on day 14 and its subsequent decrease, except deaths.'?","Yes, it is indirectly supported because Hydrocortisone is a type of corticosteroid that can affect cortisol levels in the body, and the sentence mentions changes in cortisol levels in relation to myocardial infarction (MI) severity and time. However, it does not directly mention Hydrocortisone's effect on cardiac arrest." +26840479,Hydrocortisone affects myocardial infarction,312,"Aldosterone levels, like cortisol, have been shown to be increased in sepsis and hemorrhagic shock.",False,"Is the triple 'Hydrocortisone affects myocardial infarction' supported by the sentence: 'Aldosterone levels, like cortisol, have been shown to be increased in sepsis and hemorrhagic shock.'?","No. The statement about aldosterone levels being increased in sepsis and hemorrhagic shock does not directly support the claim about hydrocortisone affecting myocardial infarction. Hydrocortisone is a type of corticosteroid that can affect cortisol levels in the body, but this statement does not provide evidence of a link between hydrocortisone use and a reduced risk of myocardial infarction." +24701128,Hydrocortisone affects Sepsis,313,"In this review, we summarize the effects of circadian melatonin, TSH, and cortisol on OA, focusing on how different levels of these hormones affect OA pathogenesis and recovery with respect to the circadian clock.",Undefined,"Is the triple 'Hydrocortisone affects Sepsis' supported by the sentence: 'In this review, we summarize the effects of circadian melatonin, TSH, and cortisol on OA, focusing on how different levels of these hormones affect OA pathogenesis and recovery with respect to the circadian clock.'?","The statement suggests that cortisol has an effect on osteoarthritis (OA) pathogenesis and recovery with respect to the circadian clock. While it does not directly mention sepsis, sepsis is a condition that can be influenced by cortisol levels as well. Therefore, I would say that there is an indirect support for the idea that hydrocortisone (a synthetic form of cortisol) could affect sepsis, given that cortisol has been linked to OA pathogenesis and recovery in a circadian rhythm context. However, I must emphasize that this is an indirect association and not a direct one as per your question." +21274202,Hydrocortisone affects osteoarthritis,314,"There may be a subset of patients unable to elicit an appropriate immunosuppressive response to stress through upregulation of cortisol, with resultant exacerbation of their psoriasis.",True,"Is the triple 'Hydrocortisone affects osteoarthritis' supported by the sentence: 'There may be a subset of patients unable to elicit an appropriate immunosuppressive response to stress through upregulation of cortisol, with resultant exacerbation of their psoriasis.'?","Yes, it is indirectly supported. Hydrocortisone is a synthetic form of cortisol, which is a hormone that helps reduce inflammation in the body. If a person is unable to upregulate cortisol appropriately, as mentioned in the sentence, they might not respond well to stress-induced immune responses, which could exacerbate conditions like psoriasis. However, this doesn't directly mention osteoarthritis, but it does show a relationship between cortisol (or hydrocortisone) and inflammatory conditions." +20701310,Hydrocortisone affects psoriasis,315,"In addition to local effect, topical hydrocortisone therapy of childhood dermatitis is accompanied by a systemic effect that may be pronounced in the acute phase of disease.",True,"Is the triple 'Hydrocortisone affects psoriasis' supported by the sentence: 'In addition to local effect, topical hydrocortisone therapy of childhood dermatitis is accompanied by a systemic effect that may be pronounced in the acute phase of disease.'?","Yes, it is indirectly supported because it mentions that topical hydrocortisone therapy has a systemic effect in childhood dermatitis, which could potentially have an impact on other conditions like psoriasis. However, it does not directly mention that hydrocortisone affects psoriasis." +20336537,Hydrocortisone affects dermatitis,316,"They answered the Fibromyalgia Impact Questionnaire (FIQ), Perceived Stress Questionnaire (PSQ) and McGill Pain Questionnaire (MPQ-Br), and collected saliva to evaluate CC before and after the end of each month.",False,"Is the triple 'Hydrocortisone affects dermatitis' supported by the sentence: 'They answered the Fibromyalgia Impact Questionnaire (FIQ), Perceived Stress Questionnaire (PSQ) and McGill Pain Questionnaire (MPQ-Br), and collected saliva to evaluate CC before and after the end of each month.'?","No, it is not directly nor indirectly supported, as this statement is related to a study about fibromyalgia, stress, pain, and cortisol levels, not about hydrocortisone's effect on dermatitis." +20137862,Hydrocortisone affects fibromyalgia,317,"BACKGROUND: The hypothalamic-pituitary-adrenal stress axis plays a crucial role in community-acquired pneumonia (CAP), with high cortisol being associated with disease severity and corticosteroid treatment resulting in earlier time to recovery.",True,"Is the triple 'Hydrocortisone affects fibromyalgia' supported by the sentence: 'BACKGROUND: The hypothalamic-pituitary-adrenal stress axis plays a crucial role in community-acquired pneumonia (CAP), with high cortisol being associated with disease severity and corticosteroid treatment resulting in earlier time to recovery.'?","Yes, it is indirectly supported. This is because Hydrocortisone is a type of corticosteroid, which can affect the hypothalamic-pituitary-adrenal stress axis, similar to how cortisol does in relation to community-acquired pneumonia (CAP). However, it does not directly mention fibromyalgia, so it's an indirect association." +19555227,Hydrocortisone affects pneumonia,318,"The incidence of AF was compared among patients who received hydrocortisone, and the effect of low-dose hydrocortisone on AF was estimated using the inverse probability treatment weighting method based on propensity scores.",False,"Is the triple 'Hydrocortisone affects pneumonia' supported by the sentence: 'The incidence of AF was compared among patients who received hydrocortisone, and the effect of low-dose hydrocortisone on AF was estimated using the inverse probability treatment weighting method based on propensity scores.'?","No, it is not directly nor indirectly supported. The provided statement discusses a comparison between two groups (patients who received hydrocortisone versus those who did not) in terms of Atrial Fibrillation (AF) incidence, not about any effect on pneumonia." +19531871,Hydrocortisone affects atrial fibrillation,319,"INTRODUCTION: Intrathecal administration of methotrexate, cytarabine, and hydrocortisone is commonly used to treat and prevent central nervous system involvement in leukemias and lymphomas.",False,"Is the triple 'Hydrocortisone affects atrial fibrillation' supported by the sentence: 'INTRODUCTION: Intrathecal administration of methotrexate, cytarabine, and hydrocortisone is commonly used to treat and prevent central nervous system involvement in leukemias and lymphomas.'?","No, this statement does not provide support for a direct or indirect relationship between hydrocortisone and atrial fibrillation. It discusses the use of hydrocortisone in treating central nervous system involvement in leukemias and lymphomas, not its effect on atrial fibrillation." +18495054,Hydrocortisone affects lymphoma,320,"INTRODUCTION: Intrathecal administration of methotrexate, cytarabine, and hydrocortisone is commonly used to treat and prevent central nervous system involvement in leukemias and lymphomas.",True,"Is the triple 'Hydrocortisone affects lymphoma' supported by the sentence: 'INTRODUCTION: Intrathecal administration of methotrexate, cytarabine, and hydrocortisone is commonly used to treat and prevent central nervous system involvement in leukemias and lymphomas.'?","Yes, it is indirectly supported. The given sentence mentions that hydrocortisone is used in treating and preventing central nervous system involvement in leukemias and lymphomas, which suggests that hydrocortisone does have an effect on lymphomas, albeit as part of a broader treatment regimen." +18495053,Hydrocortisone affects leukemia,321,"CONCLUSIONS: Early PN did not affect plasma concentrations of ACTH and (free) cortisol, but increased the incidence of septic shock, which statistically explained why more patients on early PN received corticosteroids.",True,"Is the triple 'Hydrocortisone affects leukemia' supported by the sentence: 'CONCLUSIONS: Early PN did not affect plasma concentrations of ACTH and (free) cortisol, but increased the incidence of septic shock, which statistically explained why more patients on early PN received corticosteroids.'?","Yes, it is indirectly supported because the increased incidence of septic shock in patients on early parenteral nutrition (PN) led to more patients receiving corticosteroids, which includes hydrocortisone, a type of corticosteroid. This suggests a potential link between hydrocortisone use and leukemia, as corticosteroids can affect white blood cell counts, a factor in leukemia. However, this is a very indirect link and further research would be needed to establish a direct causal relationship." +18310128,Hydrocortisone affects toxic shock syndrome,322,"Sixteen reacted to tixocortol pivalate and also to other corticosteroids, particularly to hydrocortisone, which could explain exacerbations of eczema in these cases.",True,"Is the triple 'Hydrocortisone affects toxic shock syndrome' supported by the sentence: 'Sixteen reacted to tixocortol pivalate and also to other corticosteroids, particularly to hydrocortisone, which could explain exacerbations of eczema in these cases.'?","Yes, it is indirectly supported because it mentions that some people had reactions to hydrocortisone, which could potentially be linked to exacerbations of eczema, although it does not specifically mention toxic shock syndrome." +17910566,Hydrocortisone affects atopic eczema,323,"Finally, transient pre-treatment of healthy humans with cortisol induces a bi-phasic response during a later, delayed systemic inflammatory response: an intermediate cortisol concentration augments inflammation while a high cortisol concentration is neither pro- nor anti-inflammatory.",True,"Is the triple 'Hydrocortisone affects atopic eczema' supported by the sentence: 'Finally, transient pre-treatment of healthy humans with cortisol induces a bi-phasic response during a later, delayed systemic inflammatory response: an intermediate cortisol concentration augments inflammation while a high cortisol concentration is neither pro- nor anti-inflammatory.'?","Yes, it is indirectly supported because hydrocortisone is a type of corticosteroid similar to cortisol, which can affect inflammation in a bi-phasic response as mentioned in the provided statement. However, it is essential to consider that further research is required to establish a direct correlation between hydrocortisone and atopic eczema based on this statement alone." +15925719,Hydrocortisone affects Inflammation,324,"Adrenaline induces the early posthypoglycaemic insulin resistance, whereas cortisol and growth hormone are important for the insulin resistance that is observed later following hypoglycaemia.",True,"Is the triple 'Hydrocortisone affects Inflammation' supported by the sentence: 'Adrenaline induces the early posthypoglycaemic insulin resistance, whereas cortisol and growth hormone are important for the insulin resistance that is observed later following hypoglycaemia.'?","Yes, it is indirectly supported because cortisol, a type of glucocorticoid like hydrocortisone, is mentioned as being involved in insulin resistance, which is a part of the inflammatory response. However, adrenaline, not hydrocortisone, is mentioned as affecting insulin resistance in this specific context." +14970164,Hydrocortisone affects Insulin resistance,325,"RESULTS: Within 24 hours following TBI, the concentrations of total cortisol, ACTH and gastrin increased proportionally to the severity of injury, especially significant in the experimental group (P less than 0.05).",False,"Is the triple 'Hydrocortisone affects Insulin resistance' supported by the sentence: 'RESULTS: Within 24 hours following TBI, the concentrations of total cortisol, ACTH and gastrin increased proportionally to the severity of injury, especially significant in the experimental group (P less than 0.05).'?","No, this statement does not directly support that Hydrocortisone affects Insulin resistance, but it does suggest a relationship between cortisol, ACTH, gastrin, and injury severity, which could potentially be linked to insulin resistance in further research." +14804311,Hydrocortisone affects injury,326,NEW OR UNIQUE INFORMATION PROVIDED: This case is the first published report of hydrocortisone-responsive hypotension and transient CIRCI associated with naturally occurring septic shock in a dog.,True,Is the triple 'Hydrocortisone affects injury' supported by the sentence: 'NEW OR UNIQUE INFORMATION PROVIDED: This case is the first published report of hydrocortisone-responsive hypotension and transient CIRCI associated with naturally occurring septic shock in a dog.'?,"Yes, it is indirectly supported. The information provided suggests that hydrocortisone has an effect on hypotension (low blood pressure) and transient CIRCI (Compensatory Anti-inflammatory Response Syndrome-induced Corticosteroid Insufficiency) in dogs with naturally occurring septic shock, which implies that it could potentially have an impact on injury as septic shock is a severe condition that can be caused by an infection or injury. However, it does not directly state that hydrocortisone affects injury, but rather a complication of a condition that can be caused by injury." +14533429,Hydrocortisone affects hypotensive disorder,327,Several types of the congenital adrenal hyperplasias are associated with decreased cortisol production and excessive adrenal sex steroid secretion.,True,Is the triple 'Hydrocortisone affects hypotensive disorder' supported by the sentence: 'Several types of the congenital adrenal hyperplasias are associated with decreased cortisol production and excessive adrenal sex steroid secretion.'?,"Yes, it is indirectly supported because decreased cortisol production (as mentioned in the sentence) could lead to an imbalance in hormonal regulation, potentially affecting blood pressure and thus contributing to a hypotensive disorder. However, it's important to note that this is a complex physiological process with many variables, so a direct causative link cannot be definitively established based on this single statement alone." +13999195,Hydrocortisone affects congenital adrenal hyperplasia,328,[Use of cryo-apheresis in the treatment of patients with cortisol-dependent bronchial asthma].,False,Is the triple 'Hydrocortisone affects congenital adrenal hyperplasia' supported by the sentence: '[Use of cryo-apheresis in the treatment of patients with cortisol-dependent bronchial asthma].'?,"No, this statement does not provide direct or indirect support for the claim that Hydrocortisone affects congenital adrenal hyperplasia, as it discusses the use of cryotherapy in treating cortisol-dependent bronchial asthma, not Hydrocortisone's impact on congenital adrenal hyperplasia." +13347553,Hydrocortisone affects asthma,329,Hypotension after recruitment was reduced by HC (0 vs. 30%).,False,Is the triple 'Hydrocortisone affects asthma' supported by the sentence: 'Hypotension after recruitment was reduced by HC (0 vs. 30%).'?,"No, the statement ""Hypotension after recruitment was reduced by HC (0 vs. 30%)"" does not provide direct or indirect support for the claim that ""Hydrocortisone affects asthma"". This statement is more related to the effects of Hydrocortisone (HC) on hypotension, not asthma." +13180935,Hydrocortisone affects hypotensive disorder,330,Fetal plasma cortisol concentrations were increased ( P < 0.05) during all levels of hypoxia.,True,Is the triple 'Hydrocortisone affects hypotensive disorder' supported by the sentence: 'Fetal plasma cortisol concentrations were increased ( P < 0.05) during all levels of hypoxia.'?,"Yes, it is indirectly supported because an increase in fetal plasma cortisol concentration could suggest an effect of hydrocortisone, which is a synthetic form of cortisol, on hypoxia, which is a state of reduced oxygen supply to the body or a particular organ, which could be related to a hypotensive disorder, which is low blood pressure, as cortisol has a role in maintaining blood pressure. However, this is a complex chain of inference and would require further research to confirm." +11695335,Hydrocortisone affects Hypoxemia,331,"INTRA-CELL CORTISOL: Attention is also focused on the potential implication of cortisol in the genesis of metabolic syndrome, because cortisol is a potent antagonist of the effect of insulin and its presence in excess enhances visceral obesity and insulin resistance.",True,"Is the triple 'Hydrocortisone affects Hypoxemia' supported by the sentence: 'INTRA-CELL CORTISOL: Attention is also focused on the potential implication of cortisol in the genesis of metabolic syndrome, because cortisol is a potent antagonist of the effect of insulin and its presence in excess enhances visceral obesity and insulin resistance.'?","Yes, there is an indirect connection between hydrocortisone, hypoxemia, and the mentioned sentence about cortisol's role in metabolic syndrome. Here's why: + + 1) Hydrocortisone is a type of corticosteroid, which can increase blood sugar levels in the body. This is similar to cortisol, a hormone that your body produces naturally in response to stress, also known as the 'stress hormone.' + 2) High blood sugar levels can lead to conditions like insulin resistance, which is mentioned in your provided sentence as a component of metabolic syndrome. Insulin resistance can lead to various health issues, one of which is obesity, particularly in the abdominal area (visceral obesity). + 3) Obesity, especially in the abdominal area, can lead to hypoventilation, a condition characterized by shallow breathing, which in turn can lead to hypoxemia, a state of low oxygen levels in the blood. + + Therefore, while hydrocortisone is not directly mentioned in the provided sentence, its effects on blood sugar levels can contribute to conditions that may lead to hyp" +11304252,Hydrocortisone affects obesity disorder,332,The effect of hydrocortisone on standardized skin-surface trauma.,False,Is the triple 'Hydrocortisone affects obesity disorder' supported by the sentence: 'The effect of hydrocortisone on standardized skin-surface trauma.'?,"No, this statement does not provide support for the relationship between Hydrocortisone and obesity disorder, as it discusses its effects on skin-surface trauma, not obesity." +10523644,Hydrocortisone affects injury,333,The action of hydrocortisone in synovial inflammation.,True,Is the triple 'Hydrocortisone affects injury' supported by the sentence: 'The action of hydrocortisone in synovial inflammation.'?,"Yes, it is indirectly supported. The sentence suggests that hydrocortisone has an effect on inflammation, which is a common response to injury. Therefore, it can be inferred that hydrocortisone could potentially affect the process of injury through its anti-inflammatory properties." +10431364,Hydrocortisone affects Inflammation,334,"The effects of stressful life events, coping, and cortisol on HIV infection.",True,"Is the triple 'Hydrocortisone affects Inflammation' supported by the sentence: 'The effects of stressful life events, coping, and cortisol on HIV infection.'?","Yes, it is indirectly supported because Hydrocortisone is a type of corticosteroid which is similar to cortisol, a hormone that your body produces in response to stress. It is used to decrease inflammation in conditions such as arthritis, lupus, asthma, bronchitis, and many others. So, in a roundabout way, the statement about stressful life events, coping, and cortisol can be linked to Hydrocortisone's effect on inflammation. However, it's important to note that this is a complex relationship involving many factors including the body's natural response to stress and the use of synthetic hormones like Hydrocortisone." +10074536,Hydrocortisone affects HIV infectious disease,335,"Immunologic and hemodynamic effects of ""low-dose"" hydrocortisone in septic shock: a double-blind, randomized, placebo-controlled, crossover study.",False,"Is the triple 'Hydrocortisone affects HIV infectious disease' supported by the sentence: 'Immunologic and hemodynamic effects of ""low-dose"" hydrocortisone in septic shock: a double-blind, randomized, placebo-controlled, crossover study.'?","No, this statement does not provide support for a direct or indirect relationship between hydrocortisone and HIV infectious disease. The study focuses on immunologic and hemodynamic effects of low-dose hydrocortisone in septic shock, which is not related to HIV infection." +9872405,Hydrocortisone affects toxic shock syndrome,336,"To prolong the anti-tumor effect some mice were also given cyclophosphamide, hydrocortisone, or a second injection of virus.",True,"Is the triple 'Hydrocortisone affects toxic shock syndrome' supported by the sentence: 'To prolong the anti-tumor effect some mice were also given cyclophosphamide, hydrocortisone, or a second injection of virus.'?","Yes, it is indirectly supported, as hydrocortisone is mentioned as being administered to mice, but there is no direct correlation established with toxic shock syndrome in this specific sentence." +9610203,Hydrocortisone affects neoplasm,337,"In conclusion, HRT in postmenopausal asthmatic women has a favorable influence on the course of asthma, reduces daily use of glucocorticosteroids and frequency of asthma exacerbations and normalizes serum concentrations of estradiol, cortisol and DHEAS, which were decreased before HRT.",False,"Is the triple 'Hydrocortisone affects neoplasm' supported by the sentence: 'In conclusion, HRT in postmenopausal asthmatic women has a favorable influence on the course of asthma, reduces daily use of glucocorticosteroids and frequency of asthma exacerbations and normalizes serum concentrations of estradiol, cortisol and DHEAS, which were decreased before HRT.'?","No, this statement does not provide direct evidence that hydrocortisone affects neoplasm. It discusses the effects of hormone replacement therapy (HRT) on asthma, estradiol, cortisol, and dehydroepiandrosterone sulfate (DHEAS) concentrations, but it does not mention anything about its impact on neoplasm (new abnormal growth of tissue)." +9120606,Hydrocortisone affects asthma,338,"However, after adjusting for the effect of obesity by multiple regression, higher plasma cortisol was independently associated with higher diastolic blood pressure in men (r = 0.21, P = 0.04) but not in women, and higher fasting serum triglyceride levels in women (r = 0.28, P < 0. 001) but not in men.",False,"Is the triple 'Hydrocortisone affects asthma' supported by the sentence: 'However, after adjusting for the effect of obesity by multiple regression, higher plasma cortisol was independently associated with higher diastolic blood pressure in men (r = 0.21, P = 0.04) but not in women, and higher fasting serum triglyceride levels in women (r = 0.28, P < 0. 001) but not in men.'?","No, this statement does not provide direct evidence that hydrocortisone affects asthma. It discusses the relationship between plasma cortisol levels, blood pressure, and triglyceride levels in men and women, but it does not mention asthma." +8017440,Hydrocortisone affects obesity disorder,339,"ii) Reduction of cortisone to cortisol in the liver may increase insulin resistance in type 2 diabetes mellitus, and inhibition of the enzyme may lead to a decrease in gluconeogenesis.",True,"Is the triple 'Hydrocortisone affects obesity disorder' supported by the sentence: 'ii) Reduction of cortisone to cortisol in the liver may increase insulin resistance in type 2 diabetes mellitus, and inhibition of the enzyme may lead to a decrease in gluconeogenesis.'?","Yes, it is indirectly supported. Hydrocortisone is a type of cortisol, a steroid hormone produced in the adrenal gland. It is known that increased levels of cortisol can lead to insulin resistance, which is a characteristic feature of type 2 diabetes mellitus. This insulin resistance can also contribute to weight gain or obesity, as insulin plays a role in regulating energy storage and use in the body. Therefore, anything that increases insulin resistance, like high levels of cortisol, could potentially contribute to obesity. The sentence you provided mentions that inhibition of an enzyme that converts cortisone to cortisol could lead to a decrease in gluconeogenesis, which is a process that contributes to high blood sugar levels in type 2 diabetes mellitus. If this inhibition also leads to lower levels of cortisol, it could potentially reduce insulin resistance and therefore also have an impact on obesity, although this is not explicitly stated in the sentence." +7974249,Hydrocortisone affects Insulin resistance,340,"Pretreatment of rats with hydrocortisone or protamin-Zn-insulin within 4 days altered in subsequent acute hypoxia (3 hrs, ""height"" 10 000 m) the isoenzyme spectrum of LDH in lungs, liver tissue and kidney cortex.",True,"Is the triple 'Hydrocortisone affects Insulin resistance' supported by the sentence: 'Pretreatment of rats with hydrocortisone or protamin-Zn-insulin within 4 days altered in subsequent acute hypoxia (3 hrs, ""height"" 10 000 m) the isoenzyme spectrum of LDH in lungs, liver tissue and kidney cortex.'?","Yes, it is possible that there is an indirect relationship between hydrocortisone and insulin resistance based on this sentence. Hydrocortisone could potentially affect insulin resistance by altering the isoenzyme spectrum of LDH (lactic dehydrogenase) in various tissues, including lungs, liver, and kidney cortex, which could in turn influence insulin sensitivity or resistance. However, this is a complex biological process and would require further investigation to confirm a direct causal relationship." +7366981,Hydrocortisone affects Hypoxemia,341,Previously we related persistent cortisol increases to memory impairments in elderly humans studied over five years.,False,Is the triple 'Hydrocortisone affects Hypoxemia' supported by the sentence: 'Previously we related persistent cortisol increases to memory impairments in elderly humans studied over five years.'?,"No, it is not directly nor indirectly supported because there is no mention of hypoxemia (a condition of low oxygen levels in the blood) in that statement, nor any connection to hydrocortisone's effects on it. The given statement talks about a correlation between sustained cortisol increases (not specifically hydrocortisone) and memory impairments in elderly humans over a period of five years, which is not relevant to hypoxemia." +7266667,Hydrocortisone affects dissociative amnesia,342,It was suggested that the progressive shift from type 1 to type 2 cytokine production characteristic of HIV infection could be at least partially provoked by the increase in the production of cortisol and the reduction of DHEA.,True,Is the triple 'Hydrocortisone affects dissociative amnesia' supported by the sentence: 'It was suggested that the progressive shift from type 1 to type 2 cytokine production characteristic of HIV infection could be at least partially provoked by the increase in the production of cortisol and the reduction of DHEA.'?,"Yes, it is indirectly supported. The statement suggests a relationship between HIV infection, cortisol levels, and DHEA levels. Hydrocortisone is a synthetic form of cortisol, and changes in cortisol levels could potentially impact symptoms of dissociative amnesia, although this is not explicitly stated in the provided sentence." +27426083,Hydrocortisone produces HIV infectious disease,343,CONCLUSIONS: This study suggests that 24 h urinary free cortisol could be considered as a potential index of adrenal cortisol production in patients with liver cirrhosis and it potentially detects patients with a high mortality risk.,False,Is the triple 'Hydrocortisone produces HIV infectious disease' supported by the sentence: 'CONCLUSIONS: This study suggests that 24 h urinary free cortisol could be considered as a potential index of adrenal cortisol production in patients with liver cirrhosis and it potentially detects patients with a high mortality risk.'?,"No, it does not support that claim. The provided conclusion is about a potential association between urinary free cortisol levels and mortality risk in patients with liver cirrhosis, not about Hydrocortisone causing HIV infectious diseases." +24427531,Hydrocortisone produces cirrhosis of liver,344,Congenital adrenal hyperplasia (CAH) is an autosomal recessive disorder that leads to the partial or complete deficiency of cortisol and aldosterone production from the adrenal glands.,False,Is the triple 'Hydrocortisone produces cirrhosis of liver' supported by the sentence: 'Congenital adrenal hyperplasia (CAH) is an autosomal recessive disorder that leads to the partial or complete deficiency of cortisol and aldosterone production from the adrenal glands.'?,"No, this statement does not support that Hydrocortisone produces cirrhosis of the liver. It discusses Congenital Adrenal Hyperplasia, which is a disorder of cortisol and aldosterone production, not hydrocortisone specifically causing liver cirrhosis." +23738730,Hydrocortisone produces congenital adrenal hyperplasia,345,[Reaction of autogenous cortisol production in patients with extensive psoriasis vulgaris or atopic dermatitis following external administration of a 0.25% prednicarbate salve (W/O emulsion)].,False,Is the triple 'Hydrocortisone produces congenital adrenal hyperplasia' supported by the sentence: '[Reaction of autogenous cortisol production in patients with extensive psoriasis vulgaris or atopic dermatitis following external administration of a 0.25% prednicarbate salve (W/O emulsion)].'?,"No, this statement does not provide any direct or indirect support for the claim that Hydrocortisone produces congenital adrenal hyperplasia. The statement discusses a reaction to a topical treatment with prednicarbate in patients with certain skin conditions, but it does not mention Hydrocortisone or congenital adrenal hyperplasia." +20514012,"Hydrocortisone produces dermatitis, atopic",346,"OBJECTIVE: Corticosteroid-binding globulin (CBG), the cortisol transport protein, is cleaved from high-affinity (haCBG) to low-affinity (laCBG) CBG at sites of inflammation releasing bioavailable, anti-inflammatory cortisol.",False,"Is the triple 'Hydrocortisone produces dermatitis, atopic' supported by the sentence: 'OBJECTIVE: Corticosteroid-binding globulin (CBG), the cortisol transport protein, is cleaved from high-affinity (haCBG) to low-affinity (laCBG) CBG at sites of inflammation releasing bioavailable, anti-inflammatory cortisol.'?","No, this statement does not directly support the claim that Hydrocortisone produces dermatitis, atopic. The statement discusses the role of corticosteroid-binding globulin (CBG) in inflammation and the release of cortisol, which is a corticosteroid like Hydrocortisone. However, it does not mention any adverse effects such as dermatitis." +18924640,Hydrocortisone produces Inflammation,347,The propensity to develop type 1 diabetes or type 2 diabetes/metabolic syndrome depends on the propensity to release of cortisol which correlates with race.,False,Is the triple 'Hydrocortisone produces Inflammation' supported by the sentence: 'The propensity to develop type 1 diabetes or type 2 diabetes/metabolic syndrome depends on the propensity to release of cortisol which correlates with race.'?,"No, this statement does not support the claim that Hydrocortisone produces inflammation, directly or indirectly. The statement discusses the correlation between cortisol release and the risk of developing certain medical conditions, but it does not mention inflammation." +16473285,Hydrocortisone produces type 1 diabetes mellitus,348,"CIRCI is characterized by an inadequate production of cortisol in relation to an increased demand during periods of severe stress, particularly in critical illnesses such as sepsis or septic shock.",True,"Is the triple 'Hydrocortisone produces type 1 diabetes mellitus' supported by the sentence: 'CIRCI is characterized by an inadequate production of cortisol in relation to an increased demand during periods of severe stress, particularly in critical illnesses such as sepsis or septic shock.'?","Yes, there is an indirect connection. Hydrocortisone is a form of cortisol, a hormone that helps regulate metabolism, immune response, and stress levels, among other things. In critical illnesses like sepsis or septic shock, as mentioned in your provided statement, there can be an increased demand for cortisol due to severe stress, which can lead to a condition known as Critical Illness-Related Corticosteroid Insufficiency (CIRCI). This condition is marked by an inadequate production of cortisol in relation to demand, which can cause various complications, including metabolic disorders like hyperglycemia, which could potentially contribute to an increased risk of developing conditions like Type 1 Diabetes Mellitus in susceptible individuals over time, but more research would be needed to confirm this hypothesis as there's not enough evidence to establish a direct cause-effect relationship between hydrocortisone use in CIRCI patients and Type 1 Diabetes Mellitus development." +15760263,Hydrocortisone produces toxic shock syndrome,349,Synacthen test diagnosed Addison's disease with a clear deficiency of cortisol production.,False,Is the triple 'Hydrocortisone produces toxic shock syndrome' supported by the sentence: 'Synacthen test diagnosed Addison's disease with a clear deficiency of cortisol production.'?,"No, it is not directly or indirectly supported. Synacthen is a synthetic analog of ACTH, a hormone that stimulates the adrenal glands to produce cortisol, among other things. The Synacthen test measures the adrenal glands' response to this stimulation, which can help diagnose conditions like Addison's disease where there is a deficiency in cortisol production. However, Hydrocortisone is a medication used to replace cortisol in people with conditions like Addison's disease, not a cause of toxic shock syndrome." +15330155,Hydrocortisone produces chronic primary adrenal insufficiency,350,"Enhanced cortisol production rates, free cortisol, and 11beta-HSD-1 expression correlate with visceral fat and insulin resistance in men: effect of weight loss.",Undefined,"Is the triple 'Hydrocortisone produces chronic primary adrenal insufficiency' supported by the sentence: 'Enhanced cortisol production rates, free cortisol, and 11beta-HSD-1 expression correlate with visceral fat and insulin resistance in men: effect of weight loss.'?","11-beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD-1) is an enzyme that converts inactive cortisol to its active form, hydrocortisone, in tissues such as visceral fat, liver, and muscle. The provided sentence suggests a correlation between enhanced cortisol production rates, free cortisol, and 11beta-HSD-1 expression with visceral fat and insulin resistance in men, indicating that increased hydrocortisone levels in these tissues may contribute to these conditions. Consequently, I would interpret this as an affirmative response, with the understanding that it is an indirect correlation based on increased hydrocortisone production in tissues rather than a direct causation of chronic primary adrenal insufficiency." +14100936,Hydrocortisone produces Insulin resistance,351,"Obesity is also related to dysregulation of cortisol production by the pre-receptor enzyme, 11beta-hydroxysteroid dehydrogenase, and we speculate that this may have a role in the pathogenesis of obesity and raised ICP seen in IIH.",True,"Is the triple 'Hydrocortisone produces Insulin resistance' supported by the sentence: 'Obesity is also related to dysregulation of cortisol production by the pre-receptor enzyme, 11beta-hydroxysteroid dehydrogenase, and we speculate that this may have a role in the pathogenesis of obesity and raised ICP seen in IIH.'?","Yes, the statement you provided does lend some support, albeit indirectly, to the idea that Hydrocortisone could potentially produce Insulin Resistance. This is because Hydrocortisone, a type of corticosteroid, can influence cortisol production, which is mentioned in your statement. Cortisol has been linked to obesity, and obesity can lead to insulin resistance. However, it's important to note that this is a complex process with many variables, so it's not a direct cause-and-effect relationship." +13891079,Hydrocortisone produces obesity disorder,352,"This is an extremely rare case of bilateral adrenal tumors, in which the left adrenocortical tumor produced and secreted cortisol or both cortisol and aldosterone and the right one produced and secreted both aldosterone and cortisol, as confirmed by clinical findings and pathological studies using immunohistochemical analysis.",False,"Is the triple 'Hydrocortisone produces obesity disorder' supported by the sentence: 'This is an extremely rare case of bilateral adrenal tumors, in which the left adrenocortical tumor produced and secreted cortisol or both cortisol and aldosterone and the right one produced and secreted both aldosterone and cortisol, as confirmed by clinical findings and pathological studies using immunohistochemical analysis.'?","No, this statement does not provide any direct or indirect support for the claim that Hydrocortisone produces obesity disorder. It discusses a specific medical case involving adrenal tumors that produce cortisol and aldosterone, but it does not mention Hydrocortisone or any potential side effects such as obesity." +13796050,Hydrocortisone produces adrenal cortex neoplasm,353,"We conclude that the clinical picture of late-onset adrenal insufficiency in preterm infants is not a result of an absolute deficiency of cortisol production, but may be a result of a limited ability to synthesize sufficient cortisol for the degree of clinical stress.",False,"Is the triple 'Hydrocortisone produces adrenal cortex neoplasm' supported by the sentence: 'We conclude that the clinical picture of late-onset adrenal insufficiency in preterm infants is not a result of an absolute deficiency of cortisol production, but may be a result of a limited ability to synthesize sufficient cortisol for the degree of clinical stress.'?","No, it is not directly or indirectly supported. The given statement discusses late-onset adrenal insufficiency in preterm infants, suggesting it may be due to a limited ability to synthesize sufficient cortisol under stress, not due to an absolute deficiency of cortisol production. Hydrocortisone is a synthetic form of cortisol, and there is no mention of it causing, contributing to, or being associated with adrenal cortex neoplasms in this statement." +13783969,Hydrocortisone produces adrenocortical insufficiency,354,"Ironically, despite our understanding of the various stressors that promote chronic adult-onset asthma, most of which are known to elevate cortisol production via the hypothalamic-pituitary-adrenal (HPA) axis, inhaled and systemic corticosteroids are the mainstay for the treatment of chronic asthma.",True,"Is the triple 'Hydrocortisone produces adrenocortical insufficiency' supported by the sentence: 'Ironically, despite our understanding of the various stressors that promote chronic adult-onset asthma, most of which are known to elevate cortisol production via the hypothalamic-pituitary-adrenal (HPA) axis, inhaled and systemic corticosteroids are the mainstay for the treatment of chronic asthma.'?","Yes, it is indirectly supported. The passage mentions that stressors promote chronic adult-onset asthma and elevate cortisol production via the HPA axis. Hydrocortisone is a type of corticosteroid that can affect the HPA axis and potentially lead to adrenocortical insufficiency with prolonged use, as mentioned in your statement. However, this is not explicitly stated in the provided passage, hence it's an indirect inference." +13669597,Hydrocortisone produces asthma,355,Glucocorticoid insufficiency is common during sepsis and may result from insufficient production of cortisol or peripheral tissues resistance.,False,Is the triple 'Hydrocortisone produces asthma' supported by the sentence: 'Glucocorticoid insufficiency is common during sepsis and may result from insufficient production of cortisol or peripheral tissues resistance.'?,"No, this statement does not support the claim that Hydrocortisone produces asthma, either directly or indirectly. The statement discusses glucocorticoid insufficiency during sepsis, which may be due to inadequate cortisol production or peripheral tissue resistance, but it does not mention hydrocortisone or asthma. Hydrocortisone, a synthetic glucocorticoid, can be used to treat various conditions, including asthma, but it does not produce asthma as a side effect." +12147996,Hydrocortisone produces Sepsis,356,"This likely represents an adaptive response to LTH, to prevent excessive cortisol production that would restrict fetal growth and potentially induce preterm delivery.",False,"Is the triple 'Hydrocortisone produces Sepsis' supported by the sentence: 'This likely represents an adaptive response to LTH, to prevent excessive cortisol production that would restrict fetal growth and potentially induce preterm delivery.'?","No, it is not directly or indirectly supported. In fact, it contradicts it, as it suggests that high levels of hydrocortisone (a type of cortisol) could potentially induce preterm delivery, rather than prevent it." +11989948,Hydrocortisone produces Hypoxemia,357,"The reduction in local cortisol production which diminishes the endogenous anti-inflammatory effects, also allows for the progression of both vascular and pulmonary inflammation.",True,"Is the triple 'Hydrocortisone produces Hypoxemia' supported by the sentence: 'The reduction in local cortisol production which diminishes the endogenous anti-inflammatory effects, also allows for the progression of both vascular and pulmonary inflammation.'?","Yes, it is indirectly supported. The statement suggests that a decrease in cortisol (such as that caused by hydrocortisone) can lead to increased inflammation, which could potentially result in hypoxemia (a condition characterized by low oxygen levels in the blood). However, it's important to note that hypoxemia is not explicitly mentioned in the provided sentence, so the connection is indirect." +11730055,Hydrocortisone produces pneumonia,358,"CONCLUSIONS: Patients with newly diagnosed, untreated PC yielded significantly higher cortisol and lower estradiol serum concentrations than controls.",False,"Is the triple 'Hydrocortisone produces pneumonia' supported by the sentence: 'CONCLUSIONS: Patients with newly diagnosed, untreated PC yielded significantly higher cortisol and lower estradiol serum concentrations than controls.'?","No, it is not directly or indirectly supported, as there is no mention of Hydrocortisone, pneumonia, or any causal relationship in the provided sentence." +8328567,Hydrocortisone produces prostate cancer,359,"The tumour secreted excessive cortisol and dehydroepiandrosterone-sulphate (DHEA-S), and had invaded the right hepatic lobe and vena cava.",False,"Is the triple 'Hydrocortisone produces prostate cancer' supported by the sentence: 'The tumour secreted excessive cortisol and dehydroepiandrosterone-sulphate (DHEA-S), and had invaded the right hepatic lobe and vena cava.'?","No, this statement does not provide support for the claim that hydrocortisone produces prostate cancer. The passage mentions a tumor secreting cortisol and DHEA-S, but it does not specify that hydrocortisone was administered, nor does it indicate a link to prostate cancer. Hydrocortisone is a synthetic form of cortisol, but without further information, we cannot infer a direct relationship between hydrocortisone, this specific tumor, and prostate cancer." +8077250,Hydrocortisone produces neoplasm,360,Replacement doses of hydrocortisone were administered throughout treatment to counteract potential adrenal insufficiency secondary to the ketoconazole.,False,Is the triple 'Hydrocortisone produces neoplasm' supported by the sentence: 'Replacement doses of hydrocortisone were administered throughout treatment to counteract potential adrenal insufficiency secondary to the ketoconazole.'?,"No, it is not directly nor indirectly supported, as there is no mention of neoplasm (a type of new and abnormal growth) in this context, but rather adrenal insufficiency caused by ketoconazole treatment being counteracted with replacement doses of hydrocortisone to maintain normal adrenal function during treatment." +27711985,Hydrocortisone disrupts adrenocortical insufficiency,361,Amplication by hydrocortisone of the induction of cytotoxic response in vitro to syngeneic murine leukemias.,False,Is the triple 'Hydrocortisone disrupts adrenocortical insufficiency' supported by the sentence: 'Amplication by hydrocortisone of the induction of cytotoxic response in vitro to syngeneic murine leukemias.'?,"No, it is not directly supported because there is no mention of adrenocortical insufficiency in that sentence, nor is there a direct disruption mentioned. The relationship is not clear enough to confirm support for that statement based on this information alone." +26428860,Hydrocortisone disrupts leukemia,362,The results demonstrated that the intrarectal dose of indomethacin and hydrocortisone inhibited the development of tumors from microscopic carcinoma lesions in the large bowel and growing further.,True,Is the triple 'Hydrocortisone disrupts leukemia' supported by the sentence: 'The results demonstrated that the intrarectal dose of indomethacin and hydrocortisone inhibited the development of tumors from microscopic carcinoma lesions in the large bowel and growing further.'?,"Yes, the statement does provide some support for the idea that hydrocortisone can inhibit the growth of certain types of tumors, which aligns with the concept of hydrocortisone disrupting leukemia, although it's an indirect support as it's not specific to leukemia." +26389045,Hydrocortisone disrupts neoplasm,363,"Growth of ovarian, lung, breast, and kidney carcinomas was increased by 136%, 126%, 78% and 69%, respectively, whereas melanomas, sarcomas, and colon tumors were inhibited by hydrocortisone.",True,"Is the triple 'Hydrocortisone disrupts neoplasm' supported by the sentence: 'Growth of ovarian, lung, breast, and kidney carcinomas was increased by 136%, 126%, 78% and 69%, respectively, whereas melanomas, sarcomas, and colon tumors were inhibited by hydrocortisone.'?","Yes, because while hydrocortisone inhibits some types of cancers like melanomas, sarcomas, and colon tumors, it increases the growth rate of other types like ovarian, lung, breast, and kidney carcinomas, which could potentially disrupt the growth pattern of neoplasms (abnormal growths that can potentially become cancerous)." +26128287,Hydrocortisone disrupts melanoma,364,Insufficient cortisol limits the ability of the sick newborn to handle stress and inhibit pulmonary inflammation.,False,Is the triple 'Hydrocortisone disrupts melanoma' supported by the sentence: 'Insufficient cortisol limits the ability of the sick newborn to handle stress and inhibit pulmonary inflammation.'?,"No, it is not directly supported because it speaks about insufficiency, not an excess like in hydrocortisone usage. Also, it refers to newborns, not to melanoma." +21020907,Hydrocortisone disrupts pneumonia,365,"BACKGROUND: Hepatic 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) activity, which converts cortisone (inactive) to cortisol, is downregulated in obesity.",False,"Is the triple 'Hydrocortisone disrupts pneumonia' supported by the sentence: 'BACKGROUND: Hepatic 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) activity, which converts cortisone (inactive) to cortisol, is downregulated in obesity.'?","No, it is not directly supported because it talks about a different form of hydrocortisone (cortisol) and a different context (obesity-related downregulation of an enzyme)." +15895489,Hydrocortisone disrupts obesity disorder,366,"High-dose hydrocortisone treatment given in the first few hours after a traumatic experience was associated with significant favorable changes in the trajectory of exposure to trauma, as expressed by the reduced risk of the development of PTSD post-trauma.",False,"Is the triple 'Hydrocortisone disrupts obesity disorder' supported by the sentence: 'High-dose hydrocortisone treatment given in the first few hours after a traumatic experience was associated with significant favorable changes in the trajectory of exposure to trauma, as expressed by the reduced risk of the development of PTSD post-trauma.'?","No, it is not directly or indirectly supported, as there is no mention of disruption of obesity disorder in the provided statement about high-dose hydrocortisone treatment reducing PTSD risk post-trauma." +15750557,Hydrocortisone disrupts injury,367,"Under normal conditions, stress induces increased cortisol secretion that counteracts inflammatory reactions.",True,"Is the triple 'Hydrocortisone disrupts injury' supported by the sentence: 'Under normal conditions, stress induces increased cortisol secretion that counteracts inflammatory reactions.'?","Yes, it is indirectly supported. The statement suggests that under normal conditions, a stress response increases cortisol secretion (which is a type of steroid hormone like Hydrocortisone), which in turn counteracts inflammatory reactions. This implies that Hydrocortisone could potentially disrupt an injury-induced inflammatory response, as suggested in your statement. However, it's important to note that this is a general inference based on the given information and may not directly apply to all specific contexts or situations." +8865955,Hydrocortisone disrupts Inflammation,368,Hydrocortisone (HC) reduced the macrophage content of four murine tumors to less than half of control values.,True,Is the triple 'Hydrocortisone disrupts Inflammation' supported by the sentence: 'Hydrocortisone (HC) reduced the macrophage content of four murine tumors to less than half of control values.'?,"Yes, this statement does provide some support for the idea that Hydrocortisone disrupts inflammation, as macrophages play a key role in inflammatory responses. By reducing macrophage content, Hydrocortisone could be decreasing inflammation. However, this is an indirect support, as it doesn't directly mention inflammation but rather a key player in inflammatory processes." +26205555,Hydrocortisone prevents neoplasm,369,"Further, because infant formula contains only trace amounts of glucocorticoids, these findings suggest that cortisol in milk is a novel biological pathway through which breastfeeding may protect against later obesity.",True,"Is the triple 'Hydrocortisone prevents neoplasm' supported by the sentence: 'Further, because infant formula contains only trace amounts of glucocorticoids, these findings suggest that cortisol in milk is a novel biological pathway through which breastfeeding may protect against later obesity.'?","Yes, it is indirectly supported. The sentence suggests that cortisol in milk (a type of glucocorticoid) may have a role in protecting against later obesity, which could be interpreted as hydrocortisone (a type of glucocorticoid) potentially having a similar effect, given that it's a type of corticosteroid. However, this is a very loose interpretation as hydrocortisone and cortisol have different biological roles and effects in the body." +19342068,Hydrocortisone prevents obesity disorder,370,"Conclusions and Relevance: Among adults with severe sepsis not in septic shock, use of hydrocortisone compared with placebo did not reduce the risk of septic shock within 14 days.",False,"Is the triple 'Hydrocortisone prevents obesity disorder' supported by the sentence: 'Conclusions and Relevance: Among adults with severe sepsis not in septic shock, use of hydrocortisone compared with placebo did not reduce the risk of septic shock within 14 days.'?","No, it does not seem to be directly or indirectly supported. The statement you provided discusses a study on adults with severe sepsis, not obesity, and it suggests that hydrocortisone did not reduce the risk of septic shock within 14 days, which doesn't imply a connection to preventing obesity disorder." +19245686,Hydrocortisone prevents toxic shock syndrome,371,These findings suggest that HC may protect against hyperoxic injury in the developing pulmonary vasculature.,True,Is the triple 'Hydrocortisone prevents toxic shock syndrome' supported by the sentence: 'These findings suggest that HC may protect against hyperoxic injury in the developing pulmonary vasculature.'?,"Yes, it is possible to make an indirect connection between these two statements, but it is not a direct support. The second statement suggests a protective effect of hydrocortisone (HC) in preventing lung injury due to high oxygen levels, which is a different context from toxic shock syndrome. However, it does imply a beneficial role of hydrocortisone in preventing certain types of damage, which could theoretically extend to preventing damage in toxic shock syndrome, albeit speculatively." +18758297,Hydrocortisone prevents injury,372,OBJECTIVE: Cortisol clearance is reduced in sepsis and may contribute to the development of impaired adrenocortical function that is thought to contribute to the pathophysiology of critical illness-related corticosteroid insufficiency.,True,Is the triple 'Hydrocortisone prevents injury' supported by the sentence: 'OBJECTIVE: Cortisol clearance is reduced in sepsis and may contribute to the development of impaired adrenocortical function that is thought to contribute to the pathophysiology of critical illness-related corticosteroid insufficiency.'?,"Yes, it could be interpreted as indirect support. The statement mentions that cortisol clearance is reduced in sepsis, which could lead to impaired adrenocortical function, a condition often treated with hydrocortisone to prevent further damage, hence 'injury'. However, it's important to note that this is a loose interpretation, as the original sentence does not explicitly mention hydrocortisone or injury prevention." +17956690,Hydrocortisone prevents Sepsis,373,Hydrocortisone therapy was started to prevent adrenal insufficiency before laboratory findings for ACTH (adrenocorticotropic hormone) and cortisol levels.,True,Is the triple 'Hydrocortisone prevents Sepsis' supported by the sentence: 'Hydrocortisone therapy was started to prevent adrenal insufficiency before laboratory findings for ACTH (adrenocorticotropic hormone) and cortisol levels.'?,"Yes, it is indirectly supported because hydrocortisone is a type of steroid hormone that can prevent adrenal insufficiency, a condition that can lead to sepsis if not treated promptly. However, this statement does not explicitly state that hydrocortisone prevents sepsis, but rather it suggests that it can help manage a condition that can lead to sepsis." +16963888,Hydrocortisone prevents adrenocortical insufficiency,374,CONCLUSION: We conclude that intravenous stress doses of hydrocortisone lead to a reduction of systemic inflammation and to a potential improvement in the early outcome of patients undergoing off-pump CABG.,True,Is the triple 'Hydrocortisone prevents adrenocortical insufficiency' supported by the sentence: 'CONCLUSION: We conclude that intravenous stress doses of hydrocortisone lead to a reduction of systemic inflammation and to a potential improvement in the early outcome of patients undergoing off-pump CABG.'?,"Yes, because hydrocortisone is a type of steroid medication that can prevent inflammation, which is a symptom of adrenocortical insufficiency. The conclusion you provided suggests that hydrocortisone reduces systemic inflammation in patients undergoing off-pump CABG, which could potentially improve their early outcome. Therefore, it supports, at least indirectly, the statement that hydrocortisone prevents adrenocortical insufficiency, as this condition is characterized by a deficiency in corticosteroids, which can lead to inflammation and other symptoms." +15550113,Hydrocortisone prevents Inflammation,375,"CONCLUSION: In intubated trauma patients, the use of an intravenous stress-dose of hydrocortisone, compared with placebo, resulted in a decreased risk of hospital-acquired pneumonia.",True,"Is the triple 'Hydrocortisone prevents Inflammation' supported by the sentence: 'CONCLUSION: In intubated trauma patients, the use of an intravenous stress-dose of hydrocortisone, compared with placebo, resulted in a decreased risk of hospital-acquired pneumonia.'?","Yes, it is indirectly supported. The decreased risk of hospital-acquired pneumonia could be due to hydrocortisone's anti-inflammatory effects, which could prevent inflammation in the lungs. However, this is a complex physiological process with many variables, so it's not a direct cause-effect relationship." +15540854,Hydrocortisone prevents pneumonia,376,"Early hydrocortisone (HC) treatment may decrease the incidence of bronchopulmonary dysplasia; however, the long-term effects are still under evaluation.",False,"Is the triple 'Hydrocortisone prevents pneumonia' supported by the sentence: 'Early hydrocortisone (HC) treatment may decrease the incidence of bronchopulmonary dysplasia; however, the long-term effects are still under evaluation.'?","No, it is not directly supported because bronchopulmonary dysplasia is not the same as pneumonia, although both are lung conditions. However, since Hydrocortisone is a treatment for respiratory conditions, it could be argued that there is an indirect correlation, as improved lung health in general could potentially reduce the risk of various lung infections, including pneumonia. But this is not explicitly stated in the given sentence, hence it's not a direct support." +14020540,Hydrocortisone prevents bronchopulmonary dysplasia,377,CONCLUSION: Intravenous hydrocortisone reduced the incidence of AF after cardiac surgery.,False,Is the triple 'Hydrocortisone prevents bronchopulmonary dysplasia' supported by the sentence: 'CONCLUSION: Intravenous hydrocortisone reduced the incidence of AF after cardiac surgery.'?,"No, it is not directly supported because it refers to a different context (cardiac surgery) and does not mention bronchopulmonary dysplasia explicitly." +13075196,Hydrocortisone prevents atrial fibrillation,378,"Assuming a single dose of hydrocortisone improves sensitivity of peripheral tissues to insulin, it may be an interesting candidate for use in reducing insulin resistance in peripheral tissues of horses with several disease states.",True,"Is the triple 'Hydrocortisone prevents atrial fibrillation' supported by the sentence: 'Assuming a single dose of hydrocortisone improves sensitivity of peripheral tissues to insulin, it may be an interesting candidate for use in reducing insulin resistance in peripheral tissues of horses with several disease states.'?","Yes, it is indirectly supported. The statement suggests that Hydrocortisone improves sensitivity to insulin in peripheral tissues, which could potentially reduce insulin resistance, a condition associated with several disease states, including atrial fibrillation in humans. However, it does not directly mention atrial fibrillation in horses." +12187318,Hydrocortisone prevents Insulin resistance,379,Plasma cortisol and glucagon concentrations were not increased markedly except in a case complicated other systemic bacterial infection.,False,Is the triple 'Hydrocortisone prevents Insulin resistance' supported by the sentence: 'Plasma cortisol and glucagon concentrations were not increased markedly except in a case complicated other systemic bacterial infection.'?,"No, this statement does not provide direct support for the claim that Hydrocortisone prevents Insulin resistance. The given sentence discusses plasma cortisol levels in relation to bacterial infection, but it does not mention Hydrocortisone, Insulin, or Insulin resistance." +14643692,Hydrocortisone exacerbates Sepsis,380,"In view of the stimulatory effects of insulin and cortisol on adipogenesis, long-term stimulation of 11betaHSD reductase activity by insulin could aggravate visceral obesity.",False,"Is the triple 'Hydrocortisone exacerbates Sepsis' supported by the sentence: 'In view of the stimulatory effects of insulin and cortisol on adipogenesis, long-term stimulation of 11betaHSD reductase activity by insulin could aggravate visceral obesity.'?","No, it is not directly supported because it discusses insulin's role in adipogenesis, not Hydrocortisone's effect on sepsis. However, it does suggest a potential link between insulin, cortisol, and obesity, which could theoretically have implications for sepsis, but this would be an indirect relationship at best." +8122784,Hydrocortisone exacerbates obesity disorder,381,"For this purpose, this review article contends that plasma cortisol is linked to a greater risk of AF.",False,"Is the triple 'Hydrocortisone exacerbates obesity disorder' supported by the sentence: 'For this purpose, this review article contends that plasma cortisol is linked to a greater risk of AF.'?","No. The statement you provided does not mention Hydrocortisone or obesity, so it does not provide support for the claim that Hydrocortisone exacerbates obesity disorder. The statement discusses a link between plasma cortisol and a greater risk of atrial fibrillation (AF), not obesity." +25411585,Hydrocortisone predisposes atrial fibrillation,382,"After multivariate analysis, duration of HC stress dose administration was associated with increased risk of mortality (OR 1.11, 95% CI 1.02-1.2, p = 0.021), and total duration of HC treatment was associated with increased risk of sepsis (OR 1.04, 95% CI 1.005-1.075, p = 0.026).",False,"Is the triple 'Hydrocortisone predisposes atrial fibrillation' supported by the sentence: 'After multivariate analysis, duration of HC stress dose administration was associated with increased risk of mortality (OR 1.11, 95% CI 1.02-1.2, p = 0.021), and total duration of HC treatment was associated with increased risk of sepsis (OR 1.04, 95% CI 1.005-1.075, p = 0.026).'?","No, this sentence does not provide support for the statement that Hydrocortisone (HC) predisposes to atrial fibrillation (AFib). The sentence discusses the association of duration of HC stress dose administration with increased risk of mortality, and total duration of HC treatment with increased risk of sepsis, but it does not mention AFib." +19755964,Hydrocortisone predisposes Sepsis,383,"Plasma leptin and ghrelin levels in endotoxin-treated dogs were correlated with serum nitric oxide (r = .955 and r = .890; p < .001), procalcitonin (r = .825 and r = .716; p < .001), cortisol (r = .823 and r = .786; p < .001), and hepatorenal injury markers (r = .580 to .745 and r = .393 to .574; p < .05 to .01).",True,"Is the triple 'Hydrocortisone predisposes Sepsis' supported by the sentence: 'Plasma leptin and ghrelin levels in endotoxin-treated dogs were correlated with serum nitric oxide (r = .955 and r = .890; p < .001), procalcitonin (r = .825 and r = .716; p < .001), cortisol (r = .823 and r = .786; p < .001), and hepatorenal injury markers (r = .580 to .745 and r = .393 to .574; p < .05 to .01).'?","Yes, the statement is indirectly supported because it mentions a correlation between cortisol (which Hydrocortisone is a form of) and procalcitonin, a marker for sepsis, as well as hepatorenal injury markers, which could suggest a potential for Hydrocortisone to influence sepsis risk in a dog model of endotoxemia. However, it does not directly address Hydrocortisone's role in sepsis predisposition, so further research would be needed to confirm this link." +13712588,Hydrocortisone predisposes injury,384,Contribution of cortisol deficiency to septic shock.,True,Is the triple 'Hydrocortisone predisposes injury' supported by the sentence: 'Contribution of cortisol deficiency to septic shock.'?,"Yes, it is indirectly supported because hydrocortisone is a form of cortisol, a hormone that can decrease inflammation in the body. If a person has a deficiency in cortisol, as in septic shock, it could lead to increased inflammation and potentially injury. Therefore, administering hydrocortisone could help mitigate this effect, but it's important to note that this is a complex physiological process with many factors at play." +12555774,Hydrocortisone predisposes toxic shock syndrome,385,The objective of this study was to demonstrate the effect of stress doses of hydrocortisone during the initial phase of human septic shock on the serum values of the neurospecific protein S-100B in comparison to the inflammation markers interleukin (IL)-8 in serum and polymorphonuclear (PMN) elastase in plasma.,False,Is the triple 'Hydrocortisone predisposes toxic shock syndrome' supported by the sentence: 'The objective of this study was to demonstrate the effect of stress doses of hydrocortisone during the initial phase of human septic shock on the serum values of the neurospecific protein S-100B in comparison to the inflammation markers interleukin (IL)-8 in serum and polymorphonuclear (PMN) elastase in plasma.'?,"No, it is not directly nor indirectly supported, as the statement about hydrocortisone's role in toxic shock syndrome is not addressed in this given context about a study on stress doses of hydrocortisone during human septic shock and its effects on serum values of certain proteins and inflammation markers in comparison to other substances in different bodily fluids." +11782928,Hydrocortisone predisposes Inflammation,386,"The synergism between insulin and cortisol in stimulating energy deposition, associated with a decreased effect of corticotropin-releasing factor in stimulating energy expenditure, is likely to contribute to the development of obesity.",True,"Is the triple 'Hydrocortisone predisposes Inflammation' supported by the sentence: 'The synergism between insulin and cortisol in stimulating energy deposition, associated with a decreased effect of corticotropin-releasing factor in stimulating energy expenditure, is likely to contribute to the development of obesity.'?","Yes, it is indirectly supported. Hydrocortisone is a type of corticosteroid, which can increase insulin resistance and affect metabolism, potentially leading to inflammation as a result of obesity or other metabolic disorders. The sentence you provided discusses the synergistic effect of insulin and cortisol in energy deposition, which could contribute to obesity, a condition often associated with inflammation. Therefore, while not explicitly stated, there is an indirect connection between hydrocortisone (a form of cortisol) and inflammation in this context." +10520517,Hydrocortisone predisposes obesity disorder,387,Higher basal cortisol predicts verbal memory loss in postmenopausal women: Rancho Bernardo Study.,False,Is the triple 'Hydrocortisone predisposes obesity disorder' supported by the sentence: 'Higher basal cortisol predicts verbal memory loss in postmenopausal women: Rancho Bernardo Study.'?,"No, it is not directly or indirectly supported, as there is no mention of hydrocortisone, obesity, or a causative relationship between higher basal cortisol levels and verbal memory loss in postmenopausal women in this statement." +8615556,Hydrocortisone predisposes dissociative amnesia,388,"A growing body of evidence now suggests that endogenous cortisol, which is produced in significant quantities by the body in a diurnal rhythm, is an important regulator of allergic disease expression and allergic inflammatory responses: lung function varies along with plasma cortisol levels; the number of circulating inflammatory cells varies with plasma cortisol levels; and low levels of endogenous cortisol may be associated with risk for asthma.",False,"Is the triple 'Hydrocortisone predisposes dissociative amnesia' supported by the sentence: 'A growing body of evidence now suggests that endogenous cortisol, which is produced in significant quantities by the body in a diurnal rhythm, is an important regulator of allergic disease expression and allergic inflammatory responses: lung function varies along with plasma cortisol levels; the number of circulating inflammatory cells varies with plasma cortisol levels; and low levels of endogenous cortisol may be associated with risk for asthma.'?","No, this statement does not provide any direct or indirect support for the claim that Hydrocortisone predisposes dissociative amnesia. The statement discusses the role of endogenous cortisol in allergic disease expression and inflammatory responses, but it does not mention Hydrocortisone or any potential effects on memory or amnesia." +8552834,Hydrocortisone predisposes asthma,389,"In conclusion, the data presented here suggest that cortisol can contribute to insulin resistance in ponies with hyperlipoproteinaemia.",False,"Is the triple 'Hydrocortisone predisposes asthma' supported by the sentence: 'In conclusion, the data presented here suggest that cortisol can contribute to insulin resistance in ponies with hyperlipoproteinaemia.'?","No. The statement about cortisol's potential contribution to insulin resistance in ponies with hyperlipoproteinaemia does not directly or indirectly support the idea that hydrocortisone predisposes to asthma. The two statements discuss different subjects - one is about cortisol's potential role in insulin resistance, while the other is about hydrocortisone's possible relationship with asthma." +8002300,Hydrocortisone predisposes Insulin resistance,390,"OBJECTIVE: To investigate the relationship of cortisol concentrations during the first week of life to patent ductus arteriosus (PDA), markers of lung inflammation, and respiratory outcome in very low birth weight infants.",True,"Is the triple 'Hydrocortisone predisposes Insulin resistance' supported by the sentence: 'OBJECTIVE: To investigate the relationship of cortisol concentrations during the first week of life to patent ductus arteriosus (PDA), markers of lung inflammation, and respiratory outcome in very low birth weight infants.'?","Yes, it is indirectly supported. The sentence mentions an investigation into the relationship between cortisol concentrations (which hydrocortisone is a synthetic form of) and inflammation, which is a factor in insulin resistance. However, it does not directly mention insulin resistance." +7960726,Hydrocortisone predisposes pneumonia,391,Oral pH-modified release budesonide versus 6-methylprednisolone in active Crohn's disease.,False,Is the triple 'Hydrocortisone predisposes pneumonia' supported by the sentence: 'Oral pH-modified release budesonide versus 6-methylprednisolone in active Crohn's disease.'?,"No, it is not directly or indirectly supported because this study is comparing two different medications for treating Crohn's disease, not discussing their potential effects on pneumonia susceptibility." +27228384,Methylprednisolone related to Crohn disease,392,Pharmacokinetics of high dose methylprednisolone and use in hematological malignancies.,False,Is the triple 'Methylprednisolone related to Crohn disease' supported by the sentence: 'Pharmacokinetics of high dose methylprednisolone and use in hematological malignancies.'?,"No, that statement does not provide any direct or indirect support for a link between Methylprednisolone and Crohn's disease. It discusses the pharmacokinetics of Methylprednisolone in the context of hematological malignancies, which is unrelated to Crohn's disease." +26974005,Methylprednisolone related to hematopoietic and lymphoid system neoplasm,393,"Methylprednisolone in advanced chronic lymphocytic leukaemia: rationale for, and effectiveness of treatment suggested by DiSC assay.",True,"Is the triple 'Methylprednisolone related to hematopoietic and lymphoid system neoplasm' supported by the sentence: 'Methylprednisolone in advanced chronic lymphocytic leukaemia: rationale for, and effectiveness of treatment suggested by DiSC assay.'?","Yes, it is indirectly supported by the sentence you provided. The sentence mentions Methylprednisolone being used in treatment of advanced chronic lymphocytic leukaemia, which is a type of hematopoietic and lymphoid system neoplasm. Therefore, there is a connection, albeit indirect, between Methylprednisolone and these types of neoplasms." +26513818,Methylprednisolone related to B-cell chronic lymphocytic leukemia,394,The effects of intravenous pulse methylprednisolone on immunological and inflammatory processes in ankylosing spondylitis.,False,Is the triple 'Methylprednisolone related to B-cell chronic lymphocytic leukemia' supported by the sentence: 'The effects of intravenous pulse methylprednisolone on immunological and inflammatory processes in ankylosing spondylitis.'?,"No, this sentence does not provide any direct or indirect support for a relationship between Methylprednisolone and B-cell chronic lymphocytic leukemia. It discusses the effects of Methylprednisolone on immunological and inflammatory processes in ankylosing spondylitis, a specific type of arthritis." +26050805,Methylprednisolone related to ankylosing spondylitis,395,The effect of methylprednisolone (MP) on the cell kinetic response to cyclophosphamide (CP) and Adriamycin (ADR) in C3H/HeJ spontaneous mammary tumors and hematopoietic tissue was investigated.,False,Is the triple 'Methylprednisolone related to ankylosing spondylitis' supported by the sentence: 'The effect of methylprednisolone (MP) on the cell kinetic response to cyclophosphamide (CP) and Adriamycin (ADR) in C3H/HeJ spontaneous mammary tumors and hematopoietic tissue was investigated.'?,"No, this statement does not support a direct or indirect relationship between Methylprednisolone (MP) and Ankylosing Spondylitis (AS). The study mentioned investigates the effects of MP on cell kinetic response to cyclophosphamide (CP) and Adriamycin (ADR) in C3H/HeJ spontaneous mammary tumors and hematopoietic tissue, but it does not mention AS in any way, nor does it suggest any potential connection between MP and AS." +25845844,Methylprednisolone related to breast neoplasm,396,High-dose intravenous methyl-prednisolone in chronic polymyositis/dermatomyositis.,False,Is the triple 'Methylprednisolone related to breast neoplasm' supported by the sentence: 'High-dose intravenous methyl-prednisolone in chronic polymyositis/dermatomyositis.'?,"No, it is not directly or indirectly supported. The given sentence mentions the use of high-dose intravenous methylprednisolone in chronic polymyositis/dermatomyositis, but it does not make any reference or association with breast neoplasm (breast cancer)." +25642837,Methylprednisolone related to dermatomyositis,397,Comparing Intratympanic Gentamicin with Methylprednisolone in Meniere's Disease with Non-Serviceable Hearing.,False,Is the triple 'Methylprednisolone related to dermatomyositis' supported by the sentence: 'Comparing Intratympanic Gentamicin with Methylprednisolone in Meniere's Disease with Non-Serviceable Hearing.'?,"No, it is not directly nor indirectly supported, as this study focuses on Meniere's Disease with non-serviceable hearing, not on Methylprednisolone's relation to Dermatomyositis." +25328503,Methylprednisolone related to Meniere disease,398,"High-dose methylprednisolone, vincristine, MTX, and ara-C (SOMA) as initial bulk reducing therapy in non-Hodgkin's lymphoma of unfavorable histology: preliminary results of an ongoing phase II study.",False,"Is the triple 'Methylprednisolone related to Meniere disease' supported by the sentence: 'High-dose methylprednisolone, vincristine, MTX, and ara-C (SOMA) as initial bulk reducing therapy in non-Hodgkin's lymphoma of unfavorable histology: preliminary results of an ongoing phase II study.'?","No, this statement does not provide any information about a relationship between Methylprednisolone and Meniere's disease. It discusses the use of Methylprednisolone in treating non-Hodgkin's lymphoma, not Meniere's disease." +24759961,Methylprednisolone related to non-Hodgkin lymphoma,399,A Prospective Study Comparing the Efficacy of Local Injection of Platelet-Rich Plasma (PRP) vs Methylprednisolone in Plantar Fasciitis.,False,Is the triple 'Methylprednisolone related to non-Hodgkin lymphoma' supported by the sentence: 'A Prospective Study Comparing the Efficacy of Local Injection of Platelet-Rich Plasma (PRP) vs Methylprednisolone in Plantar Fasciitis.'?,"No, this statement does not provide any evidence for a relationship between Methylprednisolone and non-Hodgkin lymphoma, directly or indirectly. The study is about comparing the efficacy of PRP vs Methylprednisolone in plantar fasciitis, a common foot disorder, not about any effects on non-Hodgkin lymphoma." +24691450,Methylprednisolone related to plantar fasciitis,400,A controlled trial of 6-methylprednisolone in acute alcoholic hepatitis.,False,Is the triple 'Methylprednisolone related to plantar fasciitis' supported by the sentence: 'A controlled trial of 6-methylprednisolone in acute alcoholic hepatitis.'?,"No, it is not supported because there is no mention or relation between Methylprednisolone, a corticosteroid, and plantar fasciitis, a common cause of heel pain, in that sentence. The sentence discusses a controlled trial involving methylprednisolone in acute alcoholic hepatitis, which is a liver disease, not a foot condition." +24586108,Methylprednisolone related to alcoholic hepatitis,401,[Short-term therapy with methylprednisolone in exacerbated obstructive respiratory tract diseases].,False,Is the triple 'Methylprednisolone related to alcoholic hepatitis' supported by the sentence: '[Short-term therapy with methylprednisolone in exacerbated obstructive respiratory tract diseases].'?,"No, that statement does not provide any information or support for a relationship between Methylprednisolone and alcoholic hepatitis, as it discusses its use in exacerbated obstructive respiratory tract diseases, not alcoholic hepatitis." +24559507,Methylprednisolone related to respiratory system disorder,402,Methylprednisolone and 60 Days in Hospital Survival in Coronavirus Disease 2019 Pneumonia.,False,Is the triple 'Methylprednisolone related to respiratory system disorder' supported by the sentence: 'Methylprednisolone and 60 Days in Hospital Survival in Coronavirus Disease 2019 Pneumonia.'?,"No, this statement does not provide evidence that Methylprednisolone is related to a respiratory system disorder. The title you provided discusses Methylprednisolone's role in survival of COVID-19 pneumonia patients, but it does not suggest any causative link between Methylprednisolone and respiratory disorders." +23573980,Methylprednisolone related to pneumonia,403,Intra-Carpal Injection of Ozone versus Methylprednisolone in Carpal Tunnel Syndrome of Systemic Sclerosis Patients: A Randomized Single-Blind Clinical Trial.,False,Is the triple 'Methylprednisolone related to pneumonia' supported by the sentence: 'Intra-Carpal Injection of Ozone versus Methylprednisolone in Carpal Tunnel Syndrome of Systemic Sclerosis Patients: A Randomized Single-Blind Clinical Trial.'?,"No, that sentence does not provide any information about a relationship between Methylprednisolone and pneumonia, directly or indirectly. It focuses on comparing intra-carpal injections of ozone versus Methylprednisolone in carpal tunnel syndrome patients with systemic sclerosis, not on potential side effects like pneumonia." +23514846,Methylprednisolone related to carpal tunnel syndrome,404,Methylprednisolone Pulses in West Syndrome: A New Weapon in the Armory-Is it Needed?,False,Is the triple 'Methylprednisolone related to carpal tunnel syndrome' supported by the sentence: 'Methylprednisolone Pulses in West Syndrome: A New Weapon in the Armory-Is it Needed?'?,"No, it is not directly addressed in that title alone, but Methylprednisolone is a corticosteroid used for various conditions, including inflammation, which may be relevant in some aspects of Carpal Tunnel Syndrome treatment, but it's not specifically mentioned in relation to Carpal Tunnel Syndrome in that title, so further context would be needed for a definitive answer." +23364897,Methylprednisolone related to West syndrome,405,Patient underwent treatment with milrinone and methylprednisolone that showed reduction in myocardial inflammation and significantly improved myocardial contractility.,False,Is the triple 'Methylprednisolone related to West syndrome' supported by the sentence: 'Patient underwent treatment with milrinone and methylprednisolone that showed reduction in myocardial inflammation and significantly improved myocardial contractility.'?,"No, this statement does not provide any information about a relationship between Methylprednisolone and West Syndrome, as it discusses its effects on myocardial inflammation and contractility in a cardiac context, not neurological disorders like West Syndrome." +22495910,Methylprednisolone related to myocarditis,406,"Neurologically, the therapeutic dosages of anticoagulants are linked to the high incidence of thrombotic complexities, while methylprednisolone is associated with myopathy.",False,"Is the triple 'Methylprednisolone related to myocarditis' supported by the sentence: 'Neurologically, the therapeutic dosages of anticoagulants are linked to the high incidence of thrombotic complexities, while methylprednisolone is associated with myopathy.'?","No, this statement does not support a direct or indirect link between Methylprednisolone and myocarditis. The sentence mentions that Methylprednisolone is associated with myopathy (muscle disease), not myocarditis (inflammation of the heart muscle)." +22175056,Methylprednisolone related to myopathy,407,"Conclusion: Based on the current data, the efficacy and safety of local injection of triamcinolone and methylprednisolone at doses of 20 and 40 mg were associated with a significant improvement in pain, functional status, and strength.",False,"Is the triple 'Methylprednisolone related to myopathy' supported by the sentence: 'Conclusion: Based on the current data, the efficacy and safety of local injection of triamcinolone and methylprednisolone at doses of 20 and 40 mg were associated with a significant improvement in pain, functional status, and strength.'?","No, it is not directly supported because it talks about methylprednisolone in relation to pain, functional status, and strength, not specifically about its relation to myopathy (muscle weakness)." +20879022,Methylprednisolone related to Pain,408,OBJECTIVE: To validate the responsiveness of cerebrospinal fluid (CSF) inflammatory biomarkers to treatment with natalizumab and methylprednisolone in progressive MS and to examine the relationship between CSF inflammatory and tissue damage biomarkers.,True,Is the triple 'Methylprednisolone related to Pain' supported by the sentence: 'OBJECTIVE: To validate the responsiveness of cerebrospinal fluid (CSF) inflammatory biomarkers to treatment with natalizumab and methylprednisolone in progressive MS and to examine the relationship between CSF inflammatory and tissue damage biomarkers.'?,"Yes, the statement does suggest a relationship between Methylprednisolone and pain, albeit indirectly. The objective mentions Methylprednisolone in relation to treatment in progressive MS, implying its use as a therapeutic agent for managing symptoms, which could include pain. However, it does not explicitly state that Methylprednisolone is directly related to pain relief or reduction." +20342058,Methylprednisolone related to chronic progressive multiple sclerosis,409,The region was identified as a significant predictor of use of intravenous methylprednisolone in MCD and MN patients.,True,Is the triple 'Methylprednisolone related to chronic progressive multiple sclerosis' supported by the sentence: 'The region was identified as a significant predictor of use of intravenous methylprednisolone in MCD and MN patients.'?,"Yes, it is indirectly supported. The sentence suggests that methylprednisolone is used in patients with MCD (Marburg's variant of Chronic Progressive Multiple Sclerosis) and MN (Neuromyelitis Optica), which implies a relationship between methylprednisolone and these forms of multiple sclerosis." +20290784,Methylprednisolone related to membranous glomerulonephritis,410,"Clinical commentary on ""Two cases of anaphylactic shock by methylprednisolone in neuromyelitis optica"".",False,"Is the triple 'Methylprednisolone related to membranous glomerulonephritis' supported by the sentence: 'Clinical commentary on ""Two cases of anaphylactic shock by methylprednisolone in neuromyelitis optica"".'?","No, it does not seem so. The provided title discusses anaphylactic shock caused by Methylprednisolone in neuromyelitis optica patients, but it does not mention anything about its relation with membranous glomerulonephritis." +20286711,Methylprednisolone related to neuromyelitis optica,411,CONCLUSION: Results show that inhalation of budesonide (2 mg 3 times/day) and systemic methylprednisolone (40 mg/day) had similar clinical outcome in AECOPD.,False,Is the triple 'Methylprednisolone related to neuromyelitis optica' supported by the sentence: 'CONCLUSION: Results show that inhalation of budesonide (2 mg 3 times/day) and systemic methylprednisolone (40 mg/day) had similar clinical outcome in AECOPD.'?,"No, it does not support a direct relationship between Methylprednisolone and Neuromyelitis Optica in this context. The conclusion you provided discusses the effects of Budesonide inhalation and systemic Methylprednisolone on Acute Exacerbations of Chronic Obstructive Pulmonary Disease (AECOPD). It does not mention Neuromyelitis Optica, which is a specific autoimmune disease affecting the central nervous system." +19340184,Methylprednisolone related to chronic obstructive pulmonary disease,412,A Clinical Trial Comparing the Safety and Efficacy of Topical Tacrolimus versus Methylprednisolone in Ocular Graft-versus-Host Disease.,False,Is the triple 'Methylprednisolone related to chronic obstructive pulmonary disease' supported by the sentence: 'A Clinical Trial Comparing the Safety and Efficacy of Topical Tacrolimus versus Methylprednisolone in Ocular Graft-versus-Host Disease.'?,"No, this statement does not provide evidence for a direct or indirect relationship between Methylprednisolone and Chronic Obstructive Pulmonary Disease (COPD). It discusses a clinical trial comparing the safety and efficacy of Topical Tacrolimus versus Methylprednisolone in Ocular Graft-versus-Host Disease, which is unrelated to COPD." +18938435,Methylprednisolone related to graft versus host disease,413,The purpose of this study was to evaluate the efficacy of supraperiosteal injection of methylprednisolone compared with an oral tablet form and intravenous (i.v.) injection in the prevention of postoperative pain and oedema associated with inflammation.,False,Is the triple 'Methylprednisolone related to graft versus host disease' supported by the sentence: 'The purpose of this study was to evaluate the efficacy of supraperiosteal injection of methylprednisolone compared with an oral tablet form and intravenous (i.v.) injection in the prevention of postoperative pain and oedema associated with inflammation.'?,"No, the statement you provided does not provide any information about a relationship between Methylprednisolone and graft versus host disease (GVHD). The statement discusses a study evaluating different methods of administering Methylprednisolone for preventing postoperative pain, oedema, and inflammation, but it does not mention GVHD, which is a specific complication that can occur in patients who have received a transplant of bone marrow or stem cells from a donor." +17333962,Methylprednisolone related to Inflammation,414,Gamma globulin and methylprednisolone in idiopathic thrombocytopenic purpura.,True,Is the triple 'Methylprednisolone related to Inflammation' supported by the sentence: 'Gamma globulin and methylprednisolone in idiopathic thrombocytopenic purpura.'?,"Yes, because Methylprednisolone is mentioned in a study about idiopathic thrombocytopenic purpura, a condition characterized by inflammation, it can be inferred that Methylprednisolone is indeed related to inflammation, albeit indirectly, as it is used in its treatment." +17288506,Methylprednisolone related to autoimmune thrombocytopenic purpura,415,Methylprednisolone and hepatotoxicity in Graves' ophthalmopathy.,False,Is the triple 'Methylprednisolone related to autoimmune thrombocytopenic purpura' supported by the sentence: 'Methylprednisolone and hepatotoxicity in Graves' ophthalmopathy.'?,"No, the statement does not provide support for a relationship between Methylprednisolone and autoimmune thrombocytopenic purpura, as it discusses hepatotoxicity in Graves' ophthalmopathy." +15936572,Methylprednisolone related to endocrine exophthalmos,416,"In orthognathic surgery, methylprednisolone > or =85 mg administered intravenously seemed sufficient to produce a significant decrease in edema, and several trials pointed toward a neuroregeneration effect, but no statistical analysis could be performed.",False,"Is the triple 'Methylprednisolone related to endocrine exophthalmos' supported by the sentence: 'In orthognathic surgery, methylprednisolone > or =85 mg administered intravenously seemed sufficient to produce a significant decrease in edema, and several trials pointed toward a neuroregeneration effect, but no statistical analysis could be performed.'?","No, the given sentence does not provide direct support for a relationship between Methylprednisolone and endocrine exophthalmos. It discusses the use of Methylprednisolone in orthognathic surgery for reducing edema and potential neuroregeneration effects, but it does not mention or imply any connection with endocrine exophthalmos, which is a condition often associated with Graves' disease, characterized by protrusion of one or both eyes." +15072844,Methylprednisolone related to Edema,417,Response of symptoms and synovitis to intra-muscular methylprednisolone in osteoarthritis of the hand: an ultrasonographic study.,True,Is the triple 'Methylprednisolone related to Edema' supported by the sentence: 'Response of symptoms and synovitis to intra-muscular methylprednisolone in osteoarthritis of the hand: an ultrasonographic study.'?,"Yes, it could be interpreted as indirect support. The study mentioned suggests that methylprednisolone, an anti-inflammatory medication, can have an impact on symptoms and synovitis in osteoarthritis of the hand, which could include edema (swelling). However, it's important to note that this is an indirect interpretation, as the study does not explicitly mention edema." +14876749,Methylprednisolone related to osteoarthritis,418,Long-term results of high-dose methylprednisolone in aplastic anemia.,False,Is the triple 'Methylprednisolone related to osteoarthritis' supported by the sentence: 'Long-term results of high-dose methylprednisolone in aplastic anemia.'?,"No, the statement does not provide any information about a relationship between Methylprednisolone and osteoarthritis, as it discusses its use in aplastic anemia, not osteoarthritis." +14399082,Methylprednisolone related to aplastic anemia,419,"Efficacy of methylprednisolone, cyclophosphamide in pediatric IgA nephropathy assessed by renal biopsy.",False,"Is the triple 'Methylprednisolone related to aplastic anemia' supported by the sentence: 'Efficacy of methylprednisolone, cyclophosphamide in pediatric IgA nephropathy assessed by renal biopsy.'?","No, the statement does not provide any information about Methylprednisolone being related to aplastic anemia, directly or indirectly. It discusses its use in pediatric IgA nephropathy, assessed by renal biopsy, but does not mention aplastic anemia." +14398237,Methylprednisolone related to IgA glomerulonephritis,420,"The impaired effect on lymphocyte blastogenesis of glucocorticoids administered in vivo, in contrast to a normal in vitro reaction to dexamethasone, together with recent findings of an altered glucocorticoid receptor pharmacology in AD, points to a decreased biological in vivo efficiency of methylprednisolone in atopic dermatitis.",False,"Is the triple 'Methylprednisolone related to IgA glomerulonephritis' supported by the sentence: 'The impaired effect on lymphocyte blastogenesis of glucocorticoids administered in vivo, in contrast to a normal in vitro reaction to dexamethasone, together with recent findings of an altered glucocorticoid receptor pharmacology in AD, points to a decreased biological in vivo efficiency of methylprednisolone in atopic dermatitis.'?","No, this statement does not provide direct evidence for a relationship between Methylprednisolone and IgA glomerulonephritis. It discusses the effects of Methylprednisolone in atopic dermatitis, not in relation to IgA glomerulonephritis." +14278238,"Methylprednisolone related to dermatitis, atopic",421,"CONCLUSION: In this single-center trial, combined vasopressin-epinephrine and methylprednisolone during resuscitation and stress-dose hydrocortisone in postresuscitation shock improved survival in refractory in-hospital cardiac arrest.",False,"Is the triple 'Methylprednisolone related to dermatitis, atopic' supported by the sentence: 'CONCLUSION: In this single-center trial, combined vasopressin-epinephrine and methylprednisolone during resuscitation and stress-dose hydrocortisone in postresuscitation shock improved survival in refractory in-hospital cardiac arrest.'?","No, this statement does not provide evidence for a direct relationship between Methylprednisolone and dermatitis, atopic. The conclusion mentions Methylprednisolone being used in resuscitation and postresuscitation shock in cardiac arrest patients but does not mention any effects on dermatitis, atopic." +14166179,Methylprednisolone related to cardiac arrest,422,Weekly bortezomib/methylprednisolone is effective and well tolerated in relapsed multiple myeloma.,False,Is the triple 'Methylprednisolone related to cardiac arrest' supported by the sentence: 'Weekly bortezomib/methylprednisolone is effective and well tolerated in relapsed multiple myeloma.'?,"No, it is not directly nor indirectly supported by that sentence, as there is no mention of any adverse effects such as cardiac arrest in relation to methylprednisolone in that statement about treatment for relapsed multiple myeloma." +12755316,Methylprednisolone related to plasma cell myeloma,423,Amsacrine combined with etoposide and high-dose methylprednisolone as salvage therapy in acute lymphoblastic leukemia in children.,False,Is the triple 'Methylprednisolone related to plasma cell myeloma' supported by the sentence: 'Amsacrine combined with etoposide and high-dose methylprednisolone as salvage therapy in acute lymphoblastic leukemia in children.'?,"No, the statement does not provide evidence for a direct relationship between Methylprednisolone and plasma cell myeloma. It discusses its use in acute lymphoblastic leukemia in children, not plasma cell myeloma." +12183687,Methylprednisolone related to acute lymphoblastic leukemia,424,Controlled clinical trial of IV cyclophosphamide versus IV methylprednisolone in severe neurological manifestations in systemic lupus erythematosus.,False,Is the triple 'Methylprednisolone related to acute lymphoblastic leukemia' supported by the sentence: 'Controlled clinical trial of IV cyclophosphamide versus IV methylprednisolone in severe neurological manifestations in systemic lupus erythematosus.'?,"No, this statement does not provide any support for a relationship between Methylprednisolone and acute lymphoblastic leukemia. It discusses the use of these drugs in systemic lupus erythematosus, not in acute lymphoblastic leukemia." +11720471,Methylprednisolone related to systemic lupus erythematosus,425,Delayed hypersensitivity to 6-methyl-prednisolone in Henoch Schoenlein syndrome.,True,Is the triple 'Methylprednisolone related to systemic lupus erythematosus' supported by the sentence: 'Delayed hypersensitivity to 6-methyl-prednisolone in Henoch Schoenlein syndrome.'?,"Yes, it could be interpreted as indirectly supportive. The mention of delayed hypersensitivity to methylprednisolone in a patient with Henoch Schoenlein syndrome suggests that this drug can elicit an immune response in certain individuals, which could potentially be relevant in the context of systemic lupus erythematosus (SLE), another autoimmune condition. However, it's important to note that this doesn't directly link methylprednisolone to SLE; it simply shows that some people may have an adverse reaction to this drug." +10812685,Methylprednisolone related to immunoglobulin a vasculitis,426,Rectal absorption of radioactive 6-alpha-methyl prednisolone in ulcerative colitis.,False,Is the triple 'Methylprednisolone related to immunoglobulin a vasculitis' supported by the sentence: 'Rectal absorption of radioactive 6-alpha-methyl prednisolone in ulcerative colitis.'?,"No, it's not directly supported because the absorption of radioactive 6-alpha-methyl prednisolone in ulcerative colitis doesn't imply a connection with immunoglobulin A vasculitis. However, methylprednisolone is a type of corticosteroid often used in treating various inflammatory conditions, including some forms of vasculitis, but it doesn't specifically mention immunoglobulin A vasculitis in your provided sentence." +10763477,Methylprednisolone related to ulcerative colitis,427,Controlled trial of pulse methylprednisolone versus two regimens of pulse cyclophosphamide in severe lupus nephritis.,False,Is the triple 'Methylprednisolone related to ulcerative colitis' supported by the sentence: 'Controlled trial of pulse methylprednisolone versus two regimens of pulse cyclophosphamide in severe lupus nephritis.'?,"No, this statement does not provide any direct or indirect support for a relationship between Methylprednisolone and ulcerative colitis. The sentence discusses a controlled trial comparing Methylprednisolone and Cyclophosphamide in treating severe lupus nephritis, with no mention of ulcerative colitis." +10558884,Methylprednisolone related to lupus nephritis,428,"The National Heart, Lung, and Blood Institute's ARDS Network currently is testing the use of methylprednisolone in late ARDS.",False,"Is the triple 'Methylprednisolone related to lupus nephritis' supported by the sentence: 'The National Heart, Lung, and Blood Institute's ARDS Network currently is testing the use of methylprednisolone in late ARDS.'?",No. This statement does not provide any direct or indirect support for a link between Methylprednisolone and lupus nephritis. It merely mentions a study conducted by the ARDS Network on using Methylprednisolone in late ARDS (Acute Respiratory Distress Syndrome). +10130342,Methylprednisolone related to adult acute respiratory distress syndrome,429,"(3) Preliminary results of an interim analysis from an ongoing randomized, prospective study showed that methylprednisolone (plus an antiviral agent?) may be useful for improving peripheral vestibular function in vestibular neuritis.",False,"Is the triple 'Methylprednisolone related to adult acute respiratory distress syndrome' supported by the sentence: '(3) Preliminary results of an interim analysis from an ongoing randomized, prospective study showed that methylprednisolone (plus an antiviral agent?) may be useful for improving peripheral vestibular function in vestibular neuritis.'?","No, it is not directly or indirectly supported by the provided sentence as it discusses the potential benefits of methylprednisolone in improving peripheral vestibular function in vestibular neuritis, not in relation to adult acute respiratory distress syndrome (ARDS)." +9229208,Methylprednisolone related to vestibular neuronitis,430,This is the first report of cyclophosphamide and methylprednisolone leading to complete and sustained resolution of GAVE in association with systemic sclerosis.,False,Is the triple 'Methylprednisolone related to vestibular neuronitis' supported by the sentence: 'This is the first report of cyclophosphamide and methylprednisolone leading to complete and sustained resolution of GAVE in association with systemic sclerosis.'?,"No, this statement does not provide any information about a relationship between Methylprednisolone and vestibular neuronitis, as it discusses its use in treating GAVE (gastric antral vascular ectasia) in association with systemic sclerosis, not vestibular neuronitis." +9003326,Methylprednisolone related to systemic sclerosis,431,We compared lymphocyte-suppressive potencies of prednisolone and methylprednisolone in rheumatoid arthritis (RA).,False,Is the triple 'Methylprednisolone related to systemic sclerosis' supported by the sentence: 'We compared lymphocyte-suppressive potencies of prednisolone and methylprednisolone in rheumatoid arthritis (RA).'?,"No, this statement does not provide any information about a relationship between Methylprednisolone and systemic sclerosis. It discusses a comparison of prednisolone and methylprednisolone in rheumatoid arthritis (RA), not in systemic sclerosis." +8447481,Methylprednisolone related to rheumatoid arthritis,432,"Despite the lucrative ""off label"" markets for methylprednisolone in SCI, no Food and Drug Association indication has been obtained.",False,"Is the triple 'Methylprednisolone related to rheumatoid arthritis' supported by the sentence: 'Despite the lucrative ""off label"" markets for methylprednisolone in SCI, no Food and Drug Association indication has been obtained.'?","No, this statement does not provide any direct or indirect support for a relationship between Methylprednisolone and rheumatoid arthritis. It discusses the lack of a Food and Drug Administration (FDA) indication for Methylprednisolone in spinal cord injuries (SCI), not its use in relation to rheumatoid arthritis." +8282330,Methylprednisolone related to spinal cord injury,433,Extraocular muscle responses to high dose intravenous methylprednisolone in myasthenia gravis.,False,Is the triple 'Methylprednisolone related to spinal cord injury' supported by the sentence: 'Extraocular muscle responses to high dose intravenous methylprednisolone in myasthenia gravis.'?,"No, this statement does not provide support for a relationship between Methylprednisolone and spinal cord injury as it discusses its use in myasthenia gravis, a different medical condition." +7944646,Methylprednisolone related to myasthenia gravis,434,The increased CSF levels of TNF-sRp55 in response to MP circumstantially suggest that this receptor could partially account for the beneficial effects of MP in acute MS.,False,Is the triple 'Methylprednisolone related to myasthenia gravis' supported by the sentence: 'The increased CSF levels of TNF-sRp55 in response to MP circumstantially suggest that this receptor could partially account for the beneficial effects of MP in acute MS.'?,"No, this statement does not provide direct evidence for a relationship between Methylprednisolone (MP) and Myasthenia Gravis (MG). The statement discusses MP's potential effects in multiple sclerosis (MS) through TNF-sRp55 in cerebrospinal fluid (CSF). Myasthenia Gravis is a different neuromuscular disorder, so while this information is interesting, it doesn't directly support a link between MP and MG." +7668599,Methylprednisolone related to multiple sclerosis,435,"Such an effect has been demonstrated between clarithromycin and methylprednisolone, two drugs that may be administered concomitantly in asthma.",False,"Is the triple 'Methylprednisolone related to multiple sclerosis' supported by the sentence: 'Such an effect has been demonstrated between clarithromycin and methylprednisolone, two drugs that may be administered concomitantly in asthma.'?","No, this statement does not provide support for a relationship between Methylprednisolone and multiple sclerosis. The sentence mentions a connection between clarithromycin and methylprednisolone in the context of asthma treatment, but it does not mention nor imply any connection with multiple sclerosis." +7443745,Methylprednisolone related to asthma,436,"In this study, low-dose methylprednisolone (0.8 mg/kg/day, MP) was used to induce a steroid-resistant lupus nephritis (SR-LN) mouse model in weeks one to four, and a therapeutic steroid dosage (MP 12 mg/kg/day) or a combined PNS (PNS 100 mg/kg/day) treatment was administered from week five to eight.",False,"Is the triple 'Methylprednisolone related to asthma' supported by the sentence: 'In this study, low-dose methylprednisolone (0.8 mg/kg/day, MP) was used to induce a steroid-resistant lupus nephritis (SR-LN) mouse model in weeks one to four, and a therapeutic steroid dosage (MP 12 mg/kg/day) or a combined PNS (PNS 100 mg/kg/day) treatment was administered from week five to eight.'?","No, the statement does not provide direct evidence that methylprednisolone is related to asthma treatment. It discusses its use in a lupus nephritis mouse model." +24973247,Methylprednisolone causes lupus nephritis,437,MP was administrated in three alternative ways: intraperitoneally during the induction of cytotoxic edema or immediately after finishing cytotoxic edema induction in a dose of 100 mg/kg b.w.; into the internal carotid artery within 2 h after finishing cytotoxic edema induction in a dose of 50 mg/kg b.w.; into internal carotid artery 10 min after edema induction by BBBd in a dose of 50 mg/kg b.w.,False,Is the triple 'Methylprednisolone causes lupus nephritis' supported by the sentence: 'MP was administrated in three alternative ways: intraperitoneally during the induction of cytotoxic edema or immediately after finishing cytotoxic edema induction in a dose of 100 mg/kg b.w.; into the internal carotid artery within 2 h after finishing cytotoxic edema induction in a dose of 50 mg/kg b.w.; into internal carotid artery 10 min after edema induction by BBBd in a dose of 50 mg/kg b.w.'?,"No, this sentence does not provide evidence for a direct link between Methylprednisolone (MP) administration and lupus nephritis. It describes different methods of MP administration, but does not mention any correlation with lupus nephritis." +24161886,Methylprednisolone causes Edema,438,"On the other hand, daily administration of methylprednisolone and tenoxicam for 4 weeks caused increased inflammation and fibrosis and wasn't affective on protection of nerve physiomorphology.",False,"Is the triple 'Methylprednisolone causes Edema' supported by the sentence: 'On the other hand, daily administration of methylprednisolone and tenoxicam for 4 weeks caused increased inflammation and fibrosis and wasn't affective on protection of nerve physiomorphology.'?",No. The given statement suggests that methylprednisolone (a corticosteroid) may not be effective in reducing inflammation when used in combination with tenoxicam for four weeks. It does not provide evidence to support a direct or indirect link between methylprednisolone use and edema (fluid retention). +18534953,Methylprednisolone causes Inflammation,439,Methylprednisolone was temporarily stopped while a broad work up for inflammatory and neoplastic causes was pursued.,True,Is the triple 'Methylprednisolone causes Inflammation' supported by the sentence: 'Methylprednisolone was temporarily stopped while a broad work up for inflammatory and neoplastic causes was pursued.'?,"Yes, it is indirectly supported. The temporary stopping of Methylprednisolone suggests that it may have a relationship with inflammatory causes, as a broad work up for inflammatory causes was pursued during this time. However, it does not directly state that Methylprednisolone causes inflammation." +18260665,Methylprednisolone causes neoplasm,440,"Pneumocystis pneumonia induced by this dose of tacrolimus has been reported in many cases; however, we encountered a rare case of Pneumocystis pneumonia induced by low-dose tacrolimus and methylprednisolone.",False,"Is the triple 'Methylprednisolone causes neoplasm' supported by the sentence: 'Pneumocystis pneumonia induced by this dose of tacrolimus has been reported in many cases; however, we encountered a rare case of Pneumocystis pneumonia induced by low-dose tacrolimus and methylprednisolone.'?","No, this sentence does not provide support for the claim that Methylprednisolone causes neoplasm, directly or indirectly. It discusses a case of Pneumocystis pneumonia induced by low-dose tacrolimus and methylprednisolone, but it does not mention nor imply any connection to neoplasm (cancer)." +17307095,Methylprednisolone causes pneumonia,441,The increased interval in the administration of MP resulted in slightly greater pain and an increased prevalence of NeP.,False,Is the triple 'Methylprednisolone causes pneumonia' supported by the sentence: 'The increased interval in the administration of MP resulted in slightly greater pain and an increased prevalence of NeP.'?,"No, it is not directly nor indirectly supported, as there is no mentioning about pneumonia, but rather about pain and NeP (Neuropathic Pain)." +15906641,Methylprednisolone causes Pain,442,"We describe that high-dose methylprednisolone (20 mg/kg) can induce multifocal osteonecrosis (ON) in conjunction with thrombocytopenia, hypofibrinogenemia, and hyperlipemia.",True,"Is the triple 'Methylprednisolone causes Pain' supported by the sentence: 'We describe that high-dose methylprednisolone (20 mg/kg) can induce multifocal osteonecrosis (ON) in conjunction with thrombocytopenia, hypofibrinogenemia, and hyperlipemia.'?","Yes, it could be interpreted as indirect support. The statement mentions a potential side effect of high-dose Methylprednisolone (20 mg/kg) therapy, which is multifocal osteonecrosis (ON). If a patient experiences this condition, it could potentially cause pain as a symptom, but it does not explicitly state that Methylprednisolone directly causes pain." +13166073,Methylprednisolone causes thrombocytopenia,443,"OBJECTIVE: To report the third published case, as of April 8, 2006, of methylprednisolone-induced toxic hepatitis.",False,"Is the triple 'Methylprednisolone causes thrombocytopenia' supported by the sentence: 'OBJECTIVE: To report the third published case, as of April 8, 2006, of methylprednisolone-induced toxic hepatitis.'?","No, this statement does not provide evidence for a direct or indirect association between Methylprednisolone and thrombocytopenia. It discusses a case of methylprednisolone-induced toxic hepatitis, not thrombocytopenia." +12672767,Methylprednisolone causes drug-induced liver injury,444,"To our knowledge, this is the first discussion considering the possibility that the methylprednisolone recommended by NASCIS may cause acute corticosteroid myopathy.",False,"Is the triple 'Methylprednisolone causes drug-induced liver injury' supported by the sentence: 'To our knowledge, this is the first discussion considering the possibility that the methylprednisolone recommended by NASCIS may cause acute corticosteroid myopathy.'?","No, it's not directly related to drug-induced liver injury. The sentence discusses acute corticosteroid myopathy as a potential side effect of methylprednisolone use." +8525599,Methylprednisolone causes myopathy,445,"However, high-dose steroids like dexamethasone or methylprednisolone had proven their clearcut anti-tumoral action.",False,"Is the triple 'Methylprednisolone causes myopathy' supported by the sentence: 'However, high-dose steroids like dexamethasone or methylprednisolone had proven their clearcut anti-tumoral action.'?",No. The statement about anti-tumoral action of methylprednisolone does not provide evidence for a causal relationship between methylprednisolone use and myopathy (muscle weakness). +27357949,Methylprednisolone affects neoplasm,446,"Methylprednisolone increases some astrogliosis and inflammation biomarkers' levels; however, it did not affect the apoptotic biomarkers.",False,"Is the triple 'Methylprednisolone affects neoplasm' supported by the sentence: 'Methylprednisolone increases some astrogliosis and inflammation biomarkers' levels; however, it did not affect the apoptotic biomarkers.'?","No, it is not directly or indirectly supported because there is no mention of neoplasm in the given statement about Methylprednisolone affecting astrogliosis, inflammation biomarkers, and apoptotic biomarkers levels." +24420470,Methylprednisolone affects Inflammation,447,Effect of Methylprednisolone on Inflammation and Coagulation in Patients with Severe COVID-19: A Retrospective Cohort Study.,True,Is the triple 'Methylprednisolone affects Inflammation' supported by the sentence: 'Effect of Methylprednisolone on Inflammation and Coagulation in Patients with Severe COVID-19: A Retrospective Cohort Study.'?,"Yes, the statement is indirectly supported by the title you provided, as it mentions that Methylprednisolone has an effect on inflammation in patients with severe COVID-19, implying that it does indeed impact inflammation in some way, even if not directly." +23472756,Methylprednisolone affects Inflammation,448,"METHODS/DESIGN: This study is a 12-week, randomised, double-blind, placebo-controlled trial analysing the effects of high-dose intravenous methylprednisolone in very early SSc.",True,"Is the triple 'Methylprednisolone affects Inflammation' supported by the sentence: 'METHODS/DESIGN: This study is a 12-week, randomised, double-blind, placebo-controlled trial analysing the effects of high-dose intravenous methylprednisolone in very early SSc.'?","Yes, the statement you provided suggests a clinical trial investigating the effects of high-dose intravenous methylprednisolone in very early Systemic Sclerosis (SSc). The fact that methylprednisolone is being studied in relation to a condition known for its inflammatory component, Systemic Sclerosis, does imply that there is an underlying assumption that methylprednisolone may have an impact on inflammation, hence providing an indirect support to your statement. However, to confirm this, one would need to examine the results and conclusions of the study itself." +20530617,Methylprednisolone affects systemic sclerosis,449,"Methods: The potential interferences Se@SiO2 nanocomposites may have to the therapeutic effect of methylprednisolone (MPS) were evaluated by classical therapeutic effect index of acute respiratory distress syndrome (ARDS), such as wet-to-dry weight ratio, inflammatory factors IL-1beta and TNF-alpha.",False,"Is the triple 'Methylprednisolone affects systemic sclerosis' supported by the sentence: 'Methods: The potential interferences Se@SiO2 nanocomposites may have to the therapeutic effect of methylprednisolone (MPS) were evaluated by classical therapeutic effect index of acute respiratory distress syndrome (ARDS), such as wet-to-dry weight ratio, inflammatory factors IL-1beta and TNF-alpha.'?","No, it is not directly supported as this passage discusses the effect of MPS on acute respiratory distress syndrome (ARDS) when used with Se@SiO2 nanocomposites, not its effect on systemic sclerosis." +20254789,Methylprednisolone affects adult acute respiratory distress syndrome,450,Our case likely represents worsening of DON due to soft tissue swelling secondary to OR despite cover with IVMP in a patient previously responsive to IVMP alone.,False,Is the triple 'Methylprednisolone affects adult acute respiratory distress syndrome' supported by the sentence: 'Our case likely represents worsening of DON due to soft tissue swelling secondary to OR despite cover with IVMP in a patient previously responsive to IVMP alone.'?,"No, it is not directly or indirectly supported. The given sentence discusses a patient with DON (a specific condition called diabetes insipidus nephrogenic) who experienced worsening despite treatment with IVMP (intravenous methylprednisolone). This does not provide evidence that methylprednisolone is effective in treating adult acute respiratory distress syndrome (ARDS)." +17649050,Methylprednisolone affects optic nerve disorder,451,[Treatment of invasive thymoma with myasthenia gravis: a case report responsive to azathioprine and methylprednisolone].,True,Is the triple 'Methylprednisolone affects optic nerve disorder' supported by the sentence: '[Treatment of invasive thymoma with myasthenia gravis: a case report responsive to azathioprine and methylprednisolone].'?,"Yes, it is supported, but indirectly. The provided case report describes a patient with both invasive thymoma and myasthenia gravis who responded to treatment with azathioprine and methylprednisolone, an immunosuppressant drug and a corticosteroid, respectively. While this does not directly state that methylprednisolone has a positive effect on optic nerve disorders, it does suggest that it has some effect on neuromuscular disorders such as myasthenia gravis, which could potentially have implications for similar conditions affecting the nervous system, including some types of optic nerve disorders. However, further research would be needed to establish a direct link between methylprednisolone and optic nerve disorders specifically." +16634377,Methylprednisolone affects myasthenia gravis,452,High-dose intravenous methylprednisolone is the first-line therapy for acute exacerbations of NMO.,True,Is the triple 'Methylprednisolone affects myasthenia gravis' supported by the sentence: 'High-dose intravenous methylprednisolone is the first-line therapy for acute exacerbations of NMO.'?,"Yes, it is indirectly supported. Myasthenia gravis and NMO (Neuromyelitis optica) both fall under autoimmune neuromuscular disorders, for which high-dose corticosteroids like Methylprednisolone can be used as a treatment option for acute exacerbations, though Methylprednisolone is not a first line treatment for Myasthenia Gravis, it can still be used off label for acute exacerbations, it is more commonly used for NMO as you mentioned in your statement, thus it is an indirect evidence of Methylprednisolone affecting Myasthenia Gravis as well." +16277488,Methylprednisolone affects neuromyelitis optica,453,"CONCLUSION: Although the delayed administration of high-dose MP did not significantly increase the severity of pain or prevalence of NeP, it should still be avoided due to the increased risk of serious side effects.",True,"Is the triple 'Methylprednisolone affects neuromyelitis optica' supported by the sentence: 'CONCLUSION: Although the delayed administration of high-dose MP did not significantly increase the severity of pain or prevalence of NeP, it should still be avoided due to the increased risk of serious side effects.'?","Yes, it is. The statement implies that Methylprednisolone (MP) does have an effect on Neuromyelitis Optica (NMO), but due to potential serious side effects, its delayed administration is not recommended. Therefore, while it suggests a relationship, it also warns against using MP in certain situations due to those risks." +15906642,Methylprednisolone affects Pain,454,Methylprednisolone has been used in other Th1 mediated diseases such as rheumatoid arthritis in an attempt to switch off the immune response and so we investigated the efficacy of three days of high dose (1 g) intravenous methylprednisolone at the start of prednisolone therapy in leprosy Type 1 reactions and nerve function impairment.,True,Is the triple 'Methylprednisolone affects Pain' supported by the sentence: 'Methylprednisolone has been used in other Th1 mediated diseases such as rheumatoid arthritis in an attempt to switch off the immune response and so we investigated the efficacy of three days of high dose (1 g) intravenous methylprednisolone at the start of prednisolone therapy in leprosy Type 1 reactions and nerve function impairment.'?,"Yes, the statement does provide indirect support for the idea that Methylprednisolone affects pain, as it suggests that Methylprednisolone is used to modulate the immune response in diseases like rheumatoid arthritis and leprosy Type 1 reactions, which could potentially alleviate pain associated with these conditions. However, it does not directly mention pain reduction as an effect of Methylprednisolone use." +15610554,Methylprednisolone affects rheumatoid arthritis,455,Myelitis in these patients was not related to graft versus host disease or immune reconstitution and was responsive to intravenous methylprednisolone and cyclophosphamide.,True,Is the triple 'Methylprednisolone affects rheumatoid arthritis' supported by the sentence: 'Myelitis in these patients was not related to graft versus host disease or immune reconstitution and was responsive to intravenous methylprednisolone and cyclophosphamide.'?,"Yes, it is indirectly supported. The statement suggests that intravenous methylprednisolone (which is a form of steroid therapy similar to Methylprednisolone) is effective in treating myelitis in patients who have undergone transplants, which implies that Methylprednisolone could potentially have similar effects on related conditions such as rheumatoid arthritis, given that both conditions involve inflammation in the body. However, this is an inference, and further research would be needed to directly support this claim." +15186368,Methylprednisolone affects graft versus host disease,456,"We investigated the effects of YM264, WEB2086, methylprednisolone and ticlopidine on puromycin-induced nephropathy in the rat.",False,"Is the triple 'Methylprednisolone affects graft versus host disease' supported by the sentence: 'We investigated the effects of YM264, WEB2086, methylprednisolone and ticlopidine on puromycin-induced nephropathy in the rat.'?","No, it is not directly supported. The mentioned study investigates the effect of these agents on puromycin-induced nephropathy in rats, not on graft versus host disease (GVHD). While it's possible that methylprednisolone could have an effect on GVHD, this specific study does not provide evidence for it." +14891106,Methylprednisolone affects kidney disorder,457,"The study strongly suggests that methylprednisolone has significant beneficial effects in human spinal cord injury, that these effects occur only when the drug is given within 8 hr, and that it helps even in patients with severe spinal cord injuries.",False,"Is the triple 'Methylprednisolone affects kidney disorder' supported by the sentence: 'The study strongly suggests that methylprednisolone has significant beneficial effects in human spinal cord injury, that these effects occur only when the drug is given within 8 hr, and that it helps even in patients with severe spinal cord injuries.'?","No, this statement does not provide any information about the relationship between Methylprednisolone and kidney disorders, directly or indirectly." +11819955,Methylprednisolone affects spinal cord injury,458,"Comparison of the effects of 2 doses of methylprednisolone on pain, swelling, and trismus after third molar surgery.",False,"Is the triple 'Methylprednisolone affects spinal cord injury' supported by the sentence: 'Comparison of the effects of 2 doses of methylprednisolone on pain, swelling, and trismus after third molar surgery.'?","No, that statement does not provide support for the idea that methylprednisolone affects spinal cord injury, as it discusses its effects after third molar surgery, not after a spinal cord injury." +10845505,Methylprednisolone affects Pain,459,Steatohepatitis during methylprednisolone therapy for ulcerative colitis exacerbation.,False,Is the triple 'Methylprednisolone affects Pain' supported by the sentence: 'Steatohepatitis during methylprednisolone therapy for ulcerative colitis exacerbation.'?,"No, it is not directly supported, as this sentence discusses a side effect of Methylprednisolone (steatohepatitis) rather than its effect on pain management in ulcerative colitis patients." +10048898,Methylprednisolone affects ulcerative colitis,460,These results suggest that increasing the uric acid concentration may represent one of the possible mechanisms of action of methylprednisolone in multiple sclerosis.,False,Is the triple 'Methylprednisolone affects ulcerative colitis' supported by the sentence: 'These results suggest that increasing the uric acid concentration may represent one of the possible mechanisms of action of methylprednisolone in multiple sclerosis.'?,"No, it is not directly related as there is no mention of ulcerative colitis in this statement, nor a direct link between methylprednisolone's effects on multiple sclerosis and its effects on ulcerative colitis. However, it does imply a potential mechanism of action for methylprednisolone in multiple sclerosis, which could potentially be studied in relation to its effects on other conditions, including ulcerative colitis, but this would require further research to establish any correlation or causation." +9646753,Methylprednisolone affects multiple sclerosis,461,"OBJECTIVE: Compare the therapeutic efficacy of an oral/metered-dose inhaler (oral/MDI) regimen to an intravenous/nebulizer (I.V./neb) regimen of methylprednisolone, cefuroxime, and inhaled albuterol and ipratropium bromide in patients hospitalized for exacerbations of chronic obstructive pulmonary disease (COPD).",False,"Is the triple 'Methylprednisolone affects multiple sclerosis' supported by the sentence: 'OBJECTIVE: Compare the therapeutic efficacy of an oral/metered-dose inhaler (oral/MDI) regimen to an intravenous/nebulizer (I.V./neb) regimen of methylprednisolone, cefuroxime, and inhaled albuterol and ipratropium bromide in patients hospitalized for exacerbations of chronic obstructive pulmonary disease (COPD).'?","No, this statement does not support that Methylprednisolone affects multiple sclerosis. It talks about its use in treating COPD exacerbations, not its impact on multiple sclerosis." +9346353,Methylprednisolone affects chronic obstructive pulmonary disease,462,"Similar to the CRPS clinical response to glucocorticoids, we now demonstrate that chronic hindpaw edema in the sciatic transection CRPS model is reversed by a continuous infusion of MP (3 mg/kg/day over 21 days), and this anti-edematous effect persists for at least 1 week after discontinuing MP.",True,"Is the triple 'Methylprednisolone affects chronic obstructive pulmonary disease' supported by the sentence: 'Similar to the CRPS clinical response to glucocorticoids, we now demonstrate that chronic hindpaw edema in the sciatic transection CRPS model is reversed by a continuous infusion of MP (3 mg/kg/day over 21 days), and this anti-edematous effect persists for at least 1 week after discontinuing MP.'?","Yes, the statement does provide some support for the idea that Methylprednisolone (MP) could have an impact on conditions associated with edema, such as Chronic Obstructive Pulmonary Disease (COPD). However, it's important to note that this study was conducted on a sciatic transection Chronic Regional Pain Syndrome (CRPS) model in rats, not directly on COPD patients or a COPD model. Therefore, while it suggests a potential mechanism, it does not directly demonstrate the effect of MP on COPD." +9107378,Methylprednisolone affects Edema,463,STUDY OBJECTIVES: To assess whether IV methylprednisolone exerts a specific early effect on dyspnea in patients with an exacerbation of asthma.,True,Is the triple 'Methylprednisolone affects Edema' supported by the sentence: 'STUDY OBJECTIVES: To assess whether IV methylprednisolone exerts a specific early effect on dyspnea in patients with an exacerbation of asthma.'?,"Yes, it is indirectly supported because methylprednisolone is a corticosteroid often used to reduce inflammation, which could potentially reduce edema (swelling) in the context of asthma exacerbation. However, the statement does not directly mention edema, but rather dyspnea (difficulty breathing), which is a symptom often associated with edema in asthma patients." +8596544,Methylprednisolone affects asthma,464,REVIEWER'S CONCLUSIONS: Cyclophosphamide regimen treatment is a form of care in neuropsychiatric involvement in systemic lupus erythematosus with no evidence to prove better effectiveness and safety when compared with methylprednisolone.,False,Is the triple 'Methylprednisolone affects asthma' supported by the sentence: 'REVIEWER'S CONCLUSIONS: Cyclophosphamide regimen treatment is a form of care in neuropsychiatric involvement in systemic lupus erythematosus with no evidence to prove better effectiveness and safety when compared with methylprednisolone.'?,"No, it is not directly nor indirectly supported, as this statement discusses Cyclophosphamide regimen treatment in neuropsychiatric involvement in systemic lupus erythematosus, not Methylprednisolone's effects on asthma." +8330909,Methylprednisolone affects systemic lupus erythematosus,465,"RESULTS: Both methylprednisolone and dexamethasone significantly reduced swelling and trismus (P < .05, Kruskal-Wallis test), whereas the methylprednisolone group had significantly less pain (P < .05, Kruskal-Wallis test) and consumed a lower amount of analgesics (P < .05, chi2 test) during the early postoperative days.",False,"Is the triple 'Methylprednisolone affects systemic lupus erythematosus' supported by the sentence: 'RESULTS: Both methylprednisolone and dexamethasone significantly reduced swelling and trismus (P < .05, Kruskal-Wallis test), whereas the methylprednisolone group had significantly less pain (P < .05, Kruskal-Wallis test) and consumed a lower amount of analgesics (P < .05, chi2 test) during the early postoperative days.'?","No, this sentence does not provide direct evidence that methylprednisolone affects systemic lupus erythematosus (SLE). The study mentioned in the sentence appears to be about the effects of methylprednisolone on swelling, trismus, pain, and analgesic consumption in the early postoperative days, not on SLE. However, it's important to note that corticosteroids like methylprednisolone are often used in the treatment of SLE, but this specific study does not provide evidence of that effect." +19744632,Methylprednisolone disrupts Edema,466,Methylprednisolone only inhibited granulocytopenia and thrombocytopenia when zymosan-activated serum or fibrinogen-depleted plasma were infused.,False,Is the triple 'Methylprednisolone disrupts Edema' supported by the sentence: 'Methylprednisolone only inhibited granulocytopenia and thrombocytopenia when zymosan-activated serum or fibrinogen-depleted plasma were infused.'?,"No, it is not directly supported because there is no mention of edema in that statement, nor is there a direct connection made between Methylprednisolone and edema in that context." +18407557,Methylprednisolone disrupts thrombocytopenia,467,"In addition, we detected that sufentanil provided prolonged pain relief up to 24 h when compared with control, whereas when we combined sufentanil plus methylprednisolone, we found that it further reduced pain and use of analgesics when compared with sufentanil.",True,"Is the triple 'Methylprednisolone disrupts thrombocytopenia' supported by the sentence: 'In addition, we detected that sufentanil provided prolonged pain relief up to 24 h when compared with control, whereas when we combined sufentanil plus methylprednisolone, we found that it further reduced pain and use of analgesics when compared with sufentanil.'?","Yes, it is indirectly supported. The statement suggests that methylprednisolone, when combined with sufentanil, reduces pain and use of analgesics more than sufentanil alone. This could imply that methylprednisolone is having some effect on the body's response to pain, which could be related to its potential impact on conditions like thrombocytopenia where platelet count is a factor. However, this is a very indirect inference and would need further research to confirm." +11106658,Methylprednisolone disrupts Pain,468,These findings demonstrate that MP may suppress post-traumatic inflammatory reaction by inhibiting both the AP-1 and NF-kappaB transcription cascades via a GR mechanism.,True,Is the triple 'Methylprednisolone disrupts Pain' supported by the sentence: 'These findings demonstrate that MP may suppress post-traumatic inflammatory reaction by inhibiting both the AP-1 and NF-kappaB transcription cascades via a GR mechanism.'?,"Yes, it is indirectly supported because it suggests a mechanism for Methylprednisolone (MP) in reducing inflammation, which could potentially lead to pain relief, although it doesn't directly mention pain." +8640603,Methylprednisolone disrupts Inflammation,469,"This study assessed the effectiveness of a ganciclovir, methylprednisolone, and immunoglobulin combination (TAGMIC) therapy in decreasing cognitive impairment and mortality among patients with Japanese encephalitis.",True,"Is the triple 'Methylprednisolone disrupts Inflammation' supported by the sentence: 'This study assessed the effectiveness of a ganciclovir, methylprednisolone, and immunoglobulin combination (TAGMIC) therapy in decreasing cognitive impairment and mortality among patients with Japanese encephalitis.'?","Yes, the statement supports it indirectly. Methylprednisolone is part of the TAGMIC therapy, which aims to decrease cognitive impairment and mortality among patients with Japanese encephalitis. Since inflammation is a key factor in Japanese encephalitis, it can be inferred that methylprednisolone, a corticosteroid with anti-inflammatory properties, plays a role in managing inflammation as part of this therapy. However, this is an indirect inference, as the statement does not explicitly mention methylprednisolone's role in inflammation reduction in this context." +23934495,Methylprednisolone prevents Cognitive impairment,470,"From indirect comparisons, most interventions showed decreased risk of developing RA compared to placebo at 12 months, reaching statistical significance for methotrexate (OR 0.16 [95% CI 0.08, 0.33]) and intramuscular methylprednisolone (OR 0.72 [95% CI 0.53, 0.99]).",False,"Is the triple 'Methylprednisolone prevents Cognitive impairment' supported by the sentence: 'From indirect comparisons, most interventions showed decreased risk of developing RA compared to placebo at 12 months, reaching statistical significance for methotrexate (OR 0.16 [95% CI 0.08, 0.33]) and intramuscular methylprednisolone (OR 0.72 [95% CI 0.53, 0.99]).'?","No, it is not supported because the given sentence discusses the effect of interventions on reducing the risk of developing rheumatoid arthritis (RA) within 12 months. It does not mention cognitive impairment or Methylprednisolone's role in preventing it directly or indirectly." +20014108,Methylprednisolone prevents rheumatoid arthritis,471,Treatment with a pulse of methylprednisolone reduced both abdominal pain and lesion size.,False,Is the triple 'Methylprednisolone prevents rheumatoid arthritis' supported by the sentence: 'Treatment with a pulse of methylprednisolone reduced both abdominal pain and lesion size.'?,"No, it is not directly supported because it talks about abdominal pain and lesion size, not about rheumatoid arthritis specifically." +18266414,Methylprednisolone prevents Abdominal pain,472,Methylprednisolone prevents propranolol-induced airway hyperreactivity in the Basenji-greyhound dog.,False,Is the triple 'Methylprednisolone prevents Abdominal pain' supported by the sentence: 'Methylprednisolone prevents propranolol-induced airway hyperreactivity in the Basenji-greyhound dog.'?,"No, it is not directly or indirectly supported, as abdominal pain is not mentioned in this statement, nor is it closely related to propranolol-induced airway hyperreactivity in dogs, even though it mentions Methylprednisolone as a preventative substance, but for a different condition." +14967074,Methylprednisolone prevents asthma,473,Administration of methylprednisolone to prevent severe ovarian hyperstimulation syndrome in patients undergoing in vitro fertilization.,False,Is the triple 'Methylprednisolone prevents asthma' supported by the sentence: 'Administration of methylprednisolone to prevent severe ovarian hyperstimulation syndrome in patients undergoing in vitro fertilization.'?,"No, it is not directly supported because it refers to a different medical context (ovarian hyperstimulation syndrome in patients undergoing in vitro fertilization) rather than specifically addressing asthma prevention with Methylprednisolone." +9744990,Methylprednisolone prevents ovarian hyperstimulation syndrome,474,"Combined methylprednisolone, bupivacaine and morphine reduced pain, joint swelling, time of immobilization, duration of sick leave and return to sports after the arthroscopic procedure.",False,"Is the triple 'Methylprednisolone prevents ovarian hyperstimulation syndrome' supported by the sentence: 'Combined methylprednisolone, bupivacaine and morphine reduced pain, joint swelling, time of immobilization, duration of sick leave and return to sports after the arthroscopic procedure.'?","No, it is not directly supported because it refers to a different medical context (arthroscopic procedure) rather than specifically addressing ovarian hyperstimulation syndrome, which is what you mentioned in your original statement about Methylprednisolone preventing it." +8345063,Methylprednisolone prevents Pain,475,Forty-eight patients who underwent bone marrow transplantation (BMT) from serologically HLA-matched unrelated donors received tacrolimus (FK506) alone or with methotrexate (MTX) and/or methylprednisolone (mPSL) to prevent graft-versus-host disease (GVHD).,True,Is the triple 'Methylprednisolone prevents Pain' supported by the sentence: 'Forty-eight patients who underwent bone marrow transplantation (BMT) from serologically HLA-matched unrelated donors received tacrolimus (FK506) alone or with methotrexate (MTX) and/or methylprednisolone (mPSL) to prevent graft-versus-host disease (GVHD).'?,"Yes, it is indirectly supported because it mentions that methylprednisolone (mPSL) is used in combination with other drugs to prevent graft-versus-host disease (GVHD) in patients undergoing bone marrow transplantation, implying that it has a role in reducing inflammation or immune response, which could potentially reduce pain. However, it does not directly state that methylprednisolone prevents pain." +8291272,Methylprednisolone prevents graft versus host disease,476,"Thus, calpeptin and methylprednisolone are found to be neuroprotective in SCI.",False,"Is the triple 'Methylprednisolone prevents graft versus host disease' supported by the sentence: 'Thus, calpeptin and methylprednisolone are found to be neuroprotective in SCI.'?","No. The statement ""Thus, calpeptin and methylprednisolone are found to be neuroprotective in SCI."" does not provide direct or indirect evidence that methylprednisolone prevents graft versus host disease. It suggests that methylprednisolone has neuroprotective effects in spinal cord injuries (SCI), but it does not imply anything about its effectiveness in preventing graft versus host disease." +7980138,Methylprednisolone prevents spinal cord injury,477,"Methylprednisolone prevents the development of autotomy and neuropathic edema in rats, but has no effect on nociceptive thresholds.",False,"Is the triple 'Methylprednisolone prevents spinal cord injury' supported by the sentence: 'Methylprednisolone prevents the development of autotomy and neuropathic edema in rats, but has no effect on nociceptive thresholds.'?","No, it is not directly supported because autotomy and neuropathic edema in rats are not equivalent to spinal cord injury in humans, although it may suggest some potential neuroprotective effects of Methylprednisolone." +7414405,Methylprednisolone prevents Edema,478,Chronically impaired renal function and the use of methylprednisolone may be the risk factors for SP.,False,Is the triple 'Methylprednisolone prevents Edema' supported by the sentence: 'Chronically impaired renal function and the use of methylprednisolone may be the risk factors for SP.'?,"No, it is not directly supported because the original sentence discusses chronically impaired renal function as a risk factor for Spinal Process (SP), not specifically about edema prevention." +18106042,Methylprednisolone predisposes pneumonia,479,"Because a common therapy for acute spinal cord injury is the use of an antiinflammatory synthetic glucocorticoid (methylprednisolone), we sought to determine mechanisms contributing to inflammation shortly after acute injury.",True,"Is the triple 'Methylprednisolone predisposes pneumonia' supported by the sentence: 'Because a common therapy for acute spinal cord injury is the use of an antiinflammatory synthetic glucocorticoid (methylprednisolone), we sought to determine mechanisms contributing to inflammation shortly after acute injury.'?","Yes, it is indirectly supported. The statement suggests that methylprednisolone is used as an anti-inflammatory therapy for spinal cord injury, implying that it could potentially influence inflammatory processes, which could theoretically include pneumonia. However, it does not directly state that methylprednisolone predisposes pneumonia." +9645180,Methylprednisolone predisposes Inflammation,480,"Combined treatments of rG-CSF with cefotaxime, cefazolin, fosfomycin, gentamicin or amphotericin B were evaluated in systemic infections with Pseudomonas aeruginosa, Escherichia coli, Serratia marcescens, Staphylococcus aureus and Candida albicans in leucopenic mice induced by pretreatment with cyclophosphamide.",False,"Is the triple 'Methylprednisolone predisposes Inflammation' supported by the sentence: 'Combined treatments of rG-CSF with cefotaxime, cefazolin, fosfomycin, gentamicin or amphotericin B were evaluated in systemic infections with Pseudomonas aeruginosa, Escherichia coli, Serratia marcescens, Staphylococcus aureus and Candida albicans in leucopenic mice induced by pretreatment with cyclophosphamide.'?","No, this statement does not provide evidence for the claim that Methylprednisolone predisposes inflammation. It discusses combined treatments with various antibiotics and antifungal agents in leucopenic mice induced by cyclophosphamide, but it does not mention Methylprednisolone or inflammation." +12905337,Cefotaxime related to Sepsis,481,"One such marker, CTX-M-15, expressed by Enterobacteriaceae produces beta-lactamases, which hydrolyze the cephalosporin group of antibiotics, such as cefotaxime, used in the treatment of both Gram-positive and negative bacterial infections.",True,"Is the triple 'Cefotaxime related to Sepsis' supported by the sentence: 'One such marker, CTX-M-15, expressed by Enterobacteriaceae produces beta-lactamases, which hydrolyze the cephalosporin group of antibiotics, such as cefotaxime, used in the treatment of both Gram-positive and negative bacterial infections.'?","Yes, the statement you provided does support a connection between Cefotaxime and Sepsis, albeit indirectly. It mentions that a specific beta-lactamase (CTX-M-15) produced by Enterobacteriaceae can hydrolyze cephalosporins like Cefotaxime. Since Cefotaxime is used in treating bacterial infections, which can include sepsis if left untreated or improperly treated, there is a connection between the two. However, it's important to note that this is a complex relationship involving many factors, including bacterial resistance and the specific circumstances of each case of sepsis." +24475300,Cefotaxime affects bacterial infectious disease,482,"CONS, Staphylococcus aureus, Enterococci, Escherichia coli, Klebsiella and Enterobacter represented 91.9% of LOS episodes and were susceptible to vancomycin and cefotaxime (96.1%), vancomycin and gentamicin (97.0%) and cloxacillin and gentamicin (38.1%).",True,"Is the triple 'Cefotaxime affects bacterial infectious disease' supported by the sentence: 'CONS, Staphylococcus aureus, Enterococci, Escherichia coli, Klebsiella and Enterobacter represented 91.9% of LOS episodes and were susceptible to vancomycin and cefotaxime (96.1%), vancomycin and gentamicin (97.0%) and cloxacillin and gentamicin (38.1%).'?","Yes, it is indirectly supported because it mentions that Cefotaxime is effective against some of the bacteria causing infections (Enterococci, Escherichia coli, Klebsiella, Enterobacter). However, it does not specifically mention Cefotaxime's effect on bacterial infectious diseases, but rather its effectiveness against certain bacteria." +23922029,Cefotaxime affects Sepsis,483,"The protective effect of cefotaxime, aztreonam and gentamicin in peritonitis induced by E. coli alone or combined with B. fragilis was evaluated by analysing mortality at 24 and 48 h after bacterial inoculation and treating the animals with two doses of each antibiotic.",True,"Is the triple 'Cefotaxime affects Sepsis' supported by the sentence: 'The protective effect of cefotaxime, aztreonam and gentamicin in peritonitis induced by E. coli alone or combined with B. fragilis was evaluated by analysing mortality at 24 and 48 h after bacterial inoculation and treating the animals with two doses of each antibiotic.'?","Yes, it is indirectly supported because Cefotaxime is an antibiotic mentioned in the study, and antibiotics like Cefotaxime can be used to treat sepsis caused by bacterial infections such as E. coli and B. fragilis. However, the study directly evaluates its effectiveness in peritonitis, not specifically sepsis." +18672205,Cefotaxime affects peritonitis,484,"HR 810 had more potent protective effect than ceftazidime (CAZ), cefoperazone (CPZ), and cefotaxime (CTX) on systemic infections induced by Escherichia coli Ec-31, Staphylococcus aureus SMITH, and Serratia marcescens Sm-6 in mice.",False,"Is the triple 'Cefotaxime affects peritonitis' supported by the sentence: 'HR 810 had more potent protective effect than ceftazidime (CAZ), cefoperazone (CPZ), and cefotaxime (CTX) on systemic infections induced by Escherichia coli Ec-31, Staphylococcus aureus SMITH, and Serratia marcescens Sm-6 in mice.'?","No, it is not directly supported, as it suggests that cefotaxime has a less potent effect compared to HR 810 on systemic infections in mice induced by certain bacteria, which contradicts the statement that cefotaxime is effective in treating peritonitis (a type of systemic infection). However, it does not rule out the possibility that cefotaxime can still have a positive effect on peritonitis, just not as strong as HR 810 in this specific study." +15853591,Cefotaxime prevents Sepsis,485,"1,480 patients, undergoing elective orthopedic and traumatic surgery, received intragluteal injections of ceftriaxone (Rocephin) to prevent bacterial infections.",False,"Is the triple 'Cefotaxime prevents Sepsis' supported by the sentence: '1,480 patients, undergoing elective orthopedic and traumatic surgery, received intragluteal injections of ceftriaxone (Rocephin) to prevent bacterial infections.'?","No, it is not directly supported because Cefotaxime is not Ceftriaxone (Rocephin). They belong to the same class of drugs (cephalosporins) but they have different chemical structures, pharmacokinetics, and indications for use. Therefore, it cannot be inferred that because Ceftriaxone can prevent bacterial infections (including sepsis), Cefotaxime will also have the same effect. However, it is possible that they might share similar properties given that they belong to the same class of drugs." +19081412,Ceftriaxone prevents bacterial infectious disease,486,Proceedings: A double blind trial of carbenoxolone and geranyl farnesylacetate in gastric ulcer.,False,Is the triple 'Ceftriaxone prevents bacterial infectious disease' supported by the sentence: 'Proceedings: A double blind trial of carbenoxolone and geranyl farnesylacetate in gastric ulcer.'?,"No, it is not directly or indirectly supported, as there is no mention of Ceftriaxone, a type of antibiotic, in the provided sentence about a clinical trial involving carbenoxolone and geranyl farnesylacetate in gastric ulcer treatment." +25827448,Gefarnate related to gastric ulcer,487,A controlled double-blind study was performed in 17 institutes using gefarnate as a control drug in order to investigate the therapeutic effect and safety of pirenzepine dihydrochloride (LS 519) in duodenal ulcer.,True,Is the triple 'Gefarnate related to gastric ulcer' supported by the sentence: 'A controlled double-blind study was performed in 17 institutes using gefarnate as a control drug in order to investigate the therapeutic effect and safety of pirenzepine dihydrochloride (LS 519) in duodenal ulcer.'?,"Yes, the statement suggests that gefarnate was used as a control drug in a study investigating the therapeutic effect and safety of a different drug in duodenal ulcers. This implies a connection between gefarnate and gastric ulcers, as duodenal ulcers are a type of gastric ulcer. However, it does not explicitly state that gefarnate is directly related to treating or causing gastric ulcers." +24296137,Gefarnate related to duodenal ulcer,488,Gefarnate at 300 mg/kg (p.o.) significantly inhibited phenylbutazone-induced gastric ulcers in rats but had no effect on other ulcer models.,True,Is the triple 'Gefarnate related to duodenal ulcer' supported by the sentence: 'Gefarnate at 300 mg/kg (p.o.) significantly inhibited phenylbutazone-induced gastric ulcers in rats but had no effect on other ulcer models.'?,"Yes, it is indirectly supported, as Gefarnate has been shown to inhibit phenylbutazone-induced gastric ulcers in rats, suggesting a potential role in gastrointestinal health, which may be relevant to duodenal ulcers, a specific type of gastric ulcers in humans, although further research is needed for a direct correlation between Gefarnate and duodenal ulcers in humans." +25993651,Gefarnate disrupts gastric ulcer,489,We tested streptomycin (ST) and neomycin (NEO) as analgesic agents applied in situ in rat paw inflammation caused by formalin or carrageenan administration.,False,Is the triple 'Gefarnate disrupts gastric ulcer' supported by the sentence: 'We tested streptomycin (ST) and neomycin (NEO) as analgesic agents applied in situ in rat paw inflammation caused by formalin or carrageenan administration.'?,"No, it is not directly supported because the study focuses on testing analgesic agents in rat paw inflammation, not on gastric ulcers or Gefarnate's effects on them." +17758516,Neobiotic related to Inflammation,490,[ON THE ACTION OF A NEOMYCIN AND THIOPENICOL PREPARATION IN EXPERIMENTAL BURNS].,False,Is the triple 'Neobiotic related to Inflammation' supported by the sentence: '[ON THE ACTION OF A NEOMYCIN AND THIOPENICOL PREPARATION IN EXPERIMENTAL BURNS].'?,"No, the provided sentence does not seem to contain any explicit or implicit information supporting a relationship between Neobiotic (a type of antibiotic) and inflammation in relation to experimental burns." +10690423,Neobiotic related to burn,491,"Therefore, we investigated the effect of long-term exposure of an antibiotic cocktail composed of Vancomycin, Neomycin, and Streptomycin, on tumor development and progression in the ApcMin/+ mouse, an established genetic model for familial adenomatous polyposis.",True,"Is the triple 'Neobiotic related to burn' supported by the sentence: 'Therefore, we investigated the effect of long-term exposure of an antibiotic cocktail composed of Vancomycin, Neomycin, and Streptomycin, on tumor development and progression in the ApcMin/+ mouse, an established genetic model for familial adenomatous polyposis.'?","Yes, it is indirectly supported because Neomycin is part of the antibiotic cocktail that was studied for its effects on tumor development and progression in a mouse model for familial adenomatous polyposis. However, it does not directly mention a relationship between Neobiotic and burns." +20263460,Neobiotic affects neoplasm,492,Ultrahigh doses of gentamicin and clinically relevant doses of neomycin affect inflammation and angiogenesis in in vivo and in vitro models.,True,Is the triple 'Neobiotic affects neoplasm' supported by the sentence: 'Ultrahigh doses of gentamicin and clinically relevant doses of neomycin affect inflammation and angiogenesis in in vivo and in vitro models.'?,"Yes, it is indirectly supported. The statement mentions that certain antibiotics (gentamicin and neomycin) affect inflammation and angiogenesis in in vivo and in vitro models. Neoplasms (abnormal growths, which can be benign or malignant) can be influenced by inflammation and angiogenesis (the formation of new blood vessels). Therefore, these antibiotics could potentially have an effect on neoplasms, but this is not explicitly stated in the provided sentence." +19744068,Neobiotic affects Inflammation,493,"Biodegradable polyaspartamide (PASPAM) was grafted with several functional groups to implement diverse roles-octadecylamine (C 18 ) for nano-aggregate formation, dopamine (DOPA) for adhesive function, neomycin (NEO) for inhibition of bacterial infection.",True,"Is the triple 'Neobiotic affects Inflammation' supported by the sentence: 'Biodegradable polyaspartamide (PASPAM) was grafted with several functional groups to implement diverse roles-octadecylamine (C 18 ) for nano-aggregate formation, dopamine (DOPA) for adhesive function, neomycin (NEO) for inhibition of bacterial infection.'?","Yes, it is indirectly supported because neomycin, one of the functional groups grafted onto biodegradable polyaspartamide, is known for its antibiotic properties, which can influence inflammation. However, the sentence does not explicitly mention inflammation in relation to neomycin." +24669492,Neobiotic disrupts bacterial infectious disease,494,Kaposi's sarcoma-associated herpesvirus-positive primary effusion lymphoma tumor formation in NOD/SCID mice is inhibited by neomycin and neamine blocking angiogenin's nuclear translocation.,True,Is the triple 'Neobiotic disrupts bacterial infectious disease' supported by the sentence: 'Kaposi's sarcoma-associated herpesvirus-positive primary effusion lymphoma tumor formation in NOD/SCID mice is inhibited by neomycin and neamine blocking angiogenin's nuclear translocation.'?,"Yes, it is indirectly supported, as it suggests that neomycin (a neobiotic) can inhibit tumor formation, which could be interpreted as a disruption of a bacterial infection process, given that bacteria play a role in tumorigenesis in some cases, such as Kaposi's sarcoma in this example, which is associated with a herpesvirus infection. However, it's important to note that this is a very specific context, so it doesn't necessarily mean that neobiotics always disrupt bacterial infectious diseases in general." +17119153,Neobiotic disrupts neoplasm,495,Neomycin and the combination of neomycin and bacitracin in the prevention of bacterial infection in surgery of the colon and/or rectum.,False,Is the triple 'Neobiotic disrupts neoplasm' supported by the sentence: 'Neomycin and the combination of neomycin and bacitracin in the prevention of bacterial infection in surgery of the colon and/or rectum.'?,"No, it is not directly supported because the sentence mentions antibiotics (neomycin, bacitracin) used in surgery, not a 'neobiotic' which is a term not commonly used in science to describe a specific type of substance. Also, it does not mention anything about disruption of neoplasms (abnormal growths of tissue)." +26428369,Neobiotic prevents bacterial infectious disease,496,Results of salvage therapy with mini-hyper-CVD and inotuzumab ozogamicin with or without blinatumomab in pre-B acute lymphoblastic leukemia.,False,Is the triple 'Neobiotic prevents bacterial infectious disease' supported by the sentence: 'Results of salvage therapy with mini-hyper-CVD and inotuzumab ozogamicin with or without blinatumomab in pre-B acute lymphoblastic leukemia.'?,"No, the statement does not provide direct support for the triple claim that Neobiotic prevents bacterial infectious diseases, as it discusses salvage therapy for pre-B acute lymphoblastic leukemia using different treatment methods, including inotuzumab ozogamicin, blinatumomab, and a procedure called mini-hyper-CVD, but it does not mention Neobiotic nor any related bacteria or infectious diseases." +25579460,BLINATUMOMAB related to Precursor B-Cell Lymphoblastic Leukemia-Lymphoma,497,"The impressive clinical success of the continuously intravenously infused T cell-redirecting bispecific antibody (T-bsAb) blinatumomab (anti-CD19 x anti-CD3), and of engineered T cells expressing anti-CD19 chimeric antigen receptors (CAR-T cells) in hematological malignancies, has led to renewed interest in a novel cancer immunotherapy strategy that combines features of antibody- and cell-based therapies.",True,"Is the triple 'BLINATUMOMAB related to Precursor B-Cell Lymphoblastic Leukemia-Lymphoma' supported by the sentence: 'The impressive clinical success of the continuously intravenously infused T cell-redirecting bispecific antibody (T-bsAb) blinatumomab (anti-CD19 x anti-CD3), and of engineered T cells expressing anti-CD19 chimeric antigen receptors (CAR-T cells) in hematological malignancies, has led to renewed interest in a novel cancer immunotherapy strategy that combines features of antibody- and cell-based therapies.'?","Yes, it is indirectly supported by that sentence because it mentions that blinatumomab, which is a T cell-redirecting bispecific antibody, has been successful in hematological malignancies, which would include Precursor B-Cell Lymphoblastic Leukemia-Lymphoma. However, it does not explicitly state that blinatumomab is used for this specific type of cancer." +22474123,BLINATUMOMAB related to hematopoietic and lymphoid system neoplasm,498,Blinatumomab and inotuzumab ozogamycin represent promising alternatives to conventional chemotherapy in acute lymphoblastic leukaemia (ALL).,True,Is the triple 'BLINATUMOMAB related to hematopoietic and lymphoid system neoplasm' supported by the sentence: 'Blinatumomab and inotuzumab ozogamycin represent promising alternatives to conventional chemotherapy in acute lymphoblastic leukaemia (ALL).'?,"Yes, the sentence does support a connection between Blinatumomab and the hematopoietic and lymphoid system neoplasm, specifically acute lymphoblastic leukaemia (ALL), which is a type of blood cancer. Blinatumomab is a medication used in the treatment of ALL, therefore it is directly related to this type of hematopoietic and lymphoid system neoplasm." +21947892,BLINATUMOMAB related to acute lymphoblastic leukemia,499,Efficacy of ciprofloxacin and dexamethasone in experimental pseudomonas endophthalmitis.,False,Is the triple 'BLINATUMOMAB related to acute lymphoblastic leukemia' supported by the sentence: 'Efficacy of ciprofloxacin and dexamethasone in experimental pseudomonas endophthalmitis.'?,"No, there is no direct or indirect relation between Blinatumomab, a bispecific T cell engager used in treating certain types of cancer like acute lymphoblastic leukemia, and ciprofloxacin and dexamethasone, which are antibiotics and steroids used in treating bacterial infections and inflammation respectively. The sentence you provided discusses the efficacy of these two drugs in treating experimental pseudomonas endophthalmitis, which is an eye infection, but it does not mention Blinatumomab or acute lymphoblastic leukemia." +27155094,Ciprofloxacin related to endophthalmitis,500,CONCLUSIONS: Combination therapy of adalimumab and ciprofloxacin is more effective than adalimumab monotherapy to achieve fistula closure in CD.,False,Is the triple 'Ciprofloxacin related to endophthalmitis' supported by the sentence: 'CONCLUSIONS: Combination therapy of adalimumab and ciprofloxacin is more effective than adalimumab monotherapy to achieve fistula closure in CD.'?,"No, this statement does not provide any information about a relationship between Ciprofloxacin and endophthalmitis. It discusses the effectiveness of a combination therapy involving Ciprofloxacin in achieving fistula closure in Crohn's disease (CD)." +16836665,Ciprofloxacin related to Crohn disease,501,"Tested substances displayed inhibitory effect towards E. coli DNA gyrase, though less than ciprofloxacin.",False,"Is the triple 'Ciprofloxacin related to Crohn disease' supported by the sentence: 'Tested substances displayed inhibitory effect towards E. coli DNA gyrase, though less than ciprofloxacin.'?","No, this statement does not provide any direct or indirect support for a connection between Ciprofloxacin and Crohn's disease. It simply states that other substances tested had less of an effect on E. coli DNA gyrase than Ciprofloxacin did." \ No newline at end of file diff --git a/false_labeled_records.csv b/false_labeled_records.csv index bd09a62..c580671 100644 --- a/false_labeled_records.csv +++ b/false_labeled_records.csv @@ -1,500 +1,501 @@ -19572117,Ciprofloxacin related to DNA Gyrase,2,"Tested substances displayed inhibitory effect towards E. coli DNA gyrase, though less than ciprofloxacin.","Is the triple ""Ciprofloxacin related to DNA Gyrase"" supported by the sentence: ""Tested substances displayed inhibitory effect towards E. coli DNA gyrase, though less than ciprofloxacin.""?",False, -26452786,Fenbendazole causes helminthiasis,3,Evaluation of granulated fenbendazole (22.2%) against induced and naturally occurring helminth infections in cats.,"Is the triple ""Fenbendazole causes helminthiasis"" supported by the sentence: ""Evaluation of granulated fenbendazole (22.2%) against induced and naturally occurring helminth infections in cats.""?",False, -22762728,Fenbendazole prevents helminthiasis,4,Fenbendazole resistance in O. ostertagi was confirmed with a total treatment failure in reducing worm burden: efficacy of 0%.,"Is the triple ""Fenbendazole prevents helminthiasis"" supported by the sentence: ""Fenbendazole resistance in O. ostertagi was confirmed with a total treatment failure in reducing worm burden: efficacy of 0%.""?",False, -21848143,Albendazole causes helminthiasis,5,Symptoms of perianal itching and visualization of visible motile worms persisted for 6 months despite being treated with multiple courses of albendazole causing a lot of frustration and distress to the caregivers.,"Is the triple ""Albendazole causes helminthiasis"" supported by the sentence: ""Symptoms of perianal itching and visualization of visible motile worms persisted for 6 months despite being treated with multiple courses of albendazole causing a lot of frustration and distress to the caregivers.""?",False, -25735916,Albendazole affects trichuriasis,6,"Ovicidal effects of albendazole in human ascariasis, ancylostomiasis and trichuriasis.","Is the triple ""Albendazole affects trichuriasis"" supported by the sentence: ""Ovicidal effects of albendazole in human ascariasis, ancylostomiasis and trichuriasis.""?",False, -24685635,Albendazole affects filarial elephantiasis,7,"A combination of drugs Ivermectin, Diethylcarbamazine citrate and Albendazole is recommended by WHO to accelerate the Global Programme to Eliminate Lymphatic Filariasis (GPELF).","Is the triple ""Albendazole affects filarial elephantiasis"" supported by the sentence: ""A combination of drugs Ivermectin, Diethylcarbamazine citrate and Albendazole is recommended by WHO to accelerate the Global Programme to Eliminate Lymphatic Filariasis (GPELF).""?",False, -18452252,Albendazole affects toxocariasis,8,Effect of albendazole in experimental toxocariasis of mice.,"Is the triple ""Albendazole affects toxocariasis"" supported by the sentence: ""Effect of albendazole in experimental toxocariasis of mice.""?",False, -16658505,Albendazole affects malaria,9,"Given the low helminth prevalence in our children, the effect of albendazole on malaria is likely to be direct.","Is the triple ""Albendazole affects malaria"" supported by the sentence: ""Given the low helminth prevalence in our children, the effect of albendazole on malaria is likely to be direct.""?",False, -13946207,Albendazole affects helminthiasis,10,"Mass co-administration of ivermectin and albendazole by the LFEP had a significant effect on STH, which was further amplified by treatment with praziquantel and albendazole 4 months later.","Is the triple ""Albendazole affects helminthiasis"" supported by the sentence: ""Mass co-administration of ivermectin and albendazole by the LFEP had a significant effect on STH, which was further amplified by treatment with praziquantel and albendazole 4 months later.""?",False, -11239060,Albendazole affects filariasis,11,The effect of single dose ivermectin alone or in combination with albendazole on Wuchereria bancrofti infection in primary school children in Tanzania.,"Is the triple ""Albendazole affects filariasis"" supported by the sentence: ""The effect of single dose ivermectin alone or in combination with albendazole on Wuchereria bancrofti infection in primary school children in Tanzania.""?",False, -24729219,Albendazole disrupts helminthiasis,12,"Additionally, compared with albendazole, it resulted in a significant reduction in adult worm and total larval counts; moreover, it caused a decrease in the number of larvae deposited in muscles, with a highly significant decrease in the inflammatory cell infiltrate around the larvae and a considerable decrease in the expression of the angiogenic marker vascular endothelial growth factor in muscles.","Is the triple ""Albendazole disrupts helminthiasis"" supported by the sentence: ""Additionally, compared with albendazole, it resulted in a significant reduction in adult worm and total larval counts; moreover, it caused a decrease in the number of larvae deposited in muscles, with a highly significant decrease in the inflammatory cell infiltrate around the larvae and a considerable decrease in the expression of the angiogenic marker vascular endothelial growth factor in muscles.""?",False, -16658503,Albendazole disrupts malaria,13,"Quarterly albendazole during childhood was associated with reduced incidence of clinical malaria (HR 0.85 (95% CI 0.73-0.98), p = 0.03).","Is the triple ""Albendazole disrupts malaria"" supported by the sentence: ""Quarterly albendazole during childhood was associated with reduced incidence of clinical malaria (HR 0.85 (95% CI 0.73-0.98), p = 0.03).""?",False, -13637338,Albendazole disrupts Hookworm Infections,14,CONCLUSIONS: Mebendazole and albendazole showed reduced efficacy against Ascaris lumbricoides and hookworm infections at the recommended doses.,"Is the triple ""Albendazole disrupts Hookworm Infections"" supported by the sentence: ""CONCLUSIONS: Mebendazole and albendazole showed reduced efficacy against Ascaris lumbricoides and hookworm infections at the recommended doses.""?",False, -15248433,Albendazole prevents filariasis,15,Evaluation of effectiveness of diethylcarbamazine/albendazole combination in reduction of Wuchereria bancrofti infection using multiple infection parameters.,"Is the triple ""Albendazole prevents filariasis"" supported by the sentence: ""Evaluation of effectiveness of diethylcarbamazine/albendazole combination in reduction of Wuchereria bancrofti infection using multiple infection parameters.""?",False, -13732336,Albendazole prevents helminthiasis,16,"Our evaluation suggests that although additional studies are needed to determine optimal treatment regimens for intestinal parasites, especially among young children and pregnant women, a five-day course of pre-departure albendazole was effective in reducing helminthic infection in treated refugees.","Is the triple ""Albendazole prevents helminthiasis"" supported by the sentence: ""Our evaluation suggests that although additional studies are needed to determine optimal treatment regimens for intestinal parasites, especially among young children and pregnant women, a five-day course of pre-departure albendazole was effective in reducing helminthic infection in treated refugees.""?",False, -15316470,Ibuprofen subclass of 2-Hydroxyibuprofen,17,"The purpose of this study was the development and validation of an LC-MS-MS method for simultaneous analysis of ibuprofen (IBP), 2-hydroxyibuprofen (2-OH-IBP) enantiomers, and carboxyibuprofen (COOH-IBP) stereoisomers in fungi culture medium, to investigate the ability of some endophytic fungi to biotransform the chiral drug IBP into its metabolites.","Is the triple ""Ibuprofen subclass of 2-Hydroxyibuprofen"" supported by the sentence: ""The purpose of this study was the development and validation of an LC-MS-MS method for simultaneous analysis of ibuprofen (IBP), 2-hydroxyibuprofen (2-OH-IBP) enantiomers, and carboxyibuprofen (COOH-IBP) stereoisomers in fungi culture medium, to investigate the ability of some endophytic fungi to biotransform the chiral drug IBP into its metabolites.""?",False, -16265626,Ibuprofen related to Arthralgia,18,"AIMS: To carry out a randomized clinical trial to compare the effect of palmitoylethanolamide (PEA) versus ibuprofen, a nonsteroidal anti-inflammatory drug (NSAID), for pain relief in temporomandibular joint (TMJ) osteoarthritis or arthralgia.","Is the triple ""Ibuprofen related to Arthralgia"" supported by the sentence: ""AIMS: To carry out a randomized clinical trial to compare the effect of palmitoylethanolamide (PEA) versus ibuprofen, a nonsteroidal anti-inflammatory drug (NSAID), for pain relief in temporomandibular joint (TMJ) osteoarthritis or arthralgia.""?",False, -14582794,Ibuprofen related to Pain,19,"We investigated the analgesic efficacy of single doses of ibuprofen, tramadol and pregabalin in menthol-evoked cold pain in a randomized, placebo-controlled four-way cross-over study in 20 healthy volunteers.","Is the triple ""Ibuprofen related to Pain"" supported by the sentence: ""We investigated the analgesic efficacy of single doses of ibuprofen, tramadol and pregabalin in menthol-evoked cold pain in a randomized, placebo-controlled four-way cross-over study in 20 healthy volunteers.""?",False, -11440746,Ibuprofen related to Toothache,20,Double blind study on emorfazone and ibuprofen in dental pain and inflammation.,"Is the triple ""Ibuprofen related to Toothache"" supported by the sentence: ""Double blind study on emorfazone and ibuprofen in dental pain and inflammation.""?",False, -9106384,Ibuprofen related to osteoarthritis,21,Glucosamine sulfate compared to ibuprofen in osteoarthritis of the knee.,"Is the triple ""Ibuprofen related to osteoarthritis"" supported by the sentence: ""Glucosamine sulfate compared to ibuprofen in osteoarthritis of the knee.""?",False, -8106985,Ibuprofen related to burn,22,INTRODUCTION: The anti-inflammatory and anticoagulant effects of ibuprofen and heparin may enhance skin perfusion in cutaneous scald burns.,"Is the triple ""Ibuprofen related to burn"" supported by the sentence: ""INTRODUCTION: The anti-inflammatory and anticoagulant effects of ibuprofen and heparin may enhance skin perfusion in cutaneous scald burns.""?",False, -13726345,Ibuprofen causes patent ductus arteriosus,23,"CONCLUSIONS: Ibuprofen-induced patent ductus arteriosus closure improved pulmonary mechanics, decreased total lung water, increased epithelial sodium channel expression, and decreased the detrimental effects of preterm birth on alveolarization.","Is the triple ""Ibuprofen causes patent ductus arteriosus"" supported by the sentence: ""CONCLUSIONS: Ibuprofen-induced patent ductus arteriosus closure improved pulmonary mechanics, decreased total lung water, increased epithelial sodium channel expression, and decreased the detrimental effects of preterm birth on alveolarization.""?",False, -13653982,Ibuprofen causes Alzheimer disease,24,Protein profile in neuroblastoma cells incubated with S- and R-enantiomers of ibuprofen by iTRAQ-coupled 2-D LC-MS/MS analysis: possible action of induced proteins on Alzheimer's disease.,"Is the triple ""Ibuprofen causes Alzheimer disease"" supported by the sentence: ""Protein profile in neuroblastoma cells incubated with S- and R-enantiomers of ibuprofen by iTRAQ-coupled 2-D LC-MS/MS analysis: possible action of induced proteins on Alzheimer's disease.""?",False, -13133316,Ibuprofen causes peptic ulcer disease,25,Protective effect of glucosamine against ibuprofen-induced peptic ulcer in rats.,"Is the triple ""Ibuprofen causes peptic ulcer disease"" supported by the sentence: ""Protective effect of glucosamine against ibuprofen-induced peptic ulcer in rats.""?",False, -12641386,Ibuprofen causes Fever,26,Ibuprofen-induced fever in Sjogren's syndrome.,"Is the triple ""Ibuprofen causes Fever"" supported by the sentence: ""Ibuprofen-induced fever in Sjogren's syndrome.""?",False, -12482174,Ibuprofen causes pancreatitis,27,There have been no prior definite cases reported of ibuprofen-induced pancreatitis.,"Is the triple ""Ibuprofen causes pancreatitis"" supported by the sentence: ""There have been no prior definite cases reported of ibuprofen-induced pancreatitis.""?",False, -12438812,Ibuprofen causes Toothache,28,"RESULTS: None of the studies established any of the COX-2 inhibitors as clearly better than ibuprofen, the current gold standard for the treatment of surgically induced dental pain.","Is the triple ""Ibuprofen causes Toothache"" supported by the sentence: ""RESULTS: None of the studies established any of the COX-2 inhibitors as clearly better than ibuprofen, the current gold standard for the treatment of surgically induced dental pain.""?",False, -12079834,Ibuprofen causes adult acute respiratory distress syndrome,29,Noncardiogenic pulmonary edema due to ibuprofen.,"Is the triple ""Ibuprofen causes adult acute respiratory distress syndrome"" supported by the sentence: ""Noncardiogenic pulmonary edema due to ibuprofen.""?",False, -11157616,Ibuprofen causes Pain,30,"In a double-blind cross-over study on 22 healthy subjects the analgesic efficacies of the antipyretic analgesic drugs ibuprofen, dipyrone and paracetamol were tested against placebo using a model of experimentally induced pain.","Is the triple ""Ibuprofen causes Pain"" supported by the sentence: ""In a double-blind cross-over study on 22 healthy subjects the analgesic efficacies of the antipyretic analgesic drugs ibuprofen, dipyrone and paracetamol were tested against placebo using a model of experimentally induced pain.""?",False, -10429873,Ibuprofen causes Hemorrhage,31,Unaltered ibuprofen-induced faecal blood loss upon coadministration of moclobemide.,"Is the triple ""Ibuprofen causes Hemorrhage"" supported by the sentence: ""Unaltered ibuprofen-induced faecal blood loss upon coadministration of moclobemide.""?",False, -9800201,Ibuprofen causes arthritic joint disease,32,The C5a antagonist (1 or 3 mg/kg/day) and/or ibuprofen (30 mg/kg/day) were administered orally on a daily basis either before or after arthritis induction.,"Is the triple ""Ibuprofen causes arthritic joint disease"" supported by the sentence: ""The C5a antagonist (1 or 3 mg/kg/day) and/or ibuprofen (30 mg/kg/day) were administered orally on a daily basis either before or after arthritis induction.""?",False, -8163776,Ibuprofen causes injury,33,RESULTS: Ketoprofen 50 mg t.d.s. suppressed prostaglandin synthesis to a significantly greater extent than ibuprofen and caused significantly more gastroduodenal injury.,"Is the triple ""Ibuprofen causes injury"" supported by the sentence: ""RESULTS: Ketoprofen 50 mg t.d.s. suppressed prostaglandin synthesis to a significantly greater extent than ibuprofen and caused significantly more gastroduodenal injury.""?",False, -26701175,Ibuprofen affects rheumatoid arthritis,34,The duration of action of sustained-release ibuprofen ('Brufen Retard') was investigated in a 14-day double-blind study involving 14 osteoarthritis and 10 rheumatoid arthritis patients.,"Is the triple ""Ibuprofen affects rheumatoid arthritis"" supported by the sentence: ""The duration of action of sustained-release ibuprofen ('Brufen Retard') was investigated in a 14-day double-blind study involving 14 osteoarthritis and 10 rheumatoid arthritis patients.""?",False, -24384432,Ibuprofen affects migraine disorder,35,This study attempts to investigate the effect of ibuprofen on reducing eye pain and migraine headaches caused by trochleitis.,"Is the triple ""Ibuprofen affects migraine disorder"" supported by the sentence: ""This study attempts to investigate the effect of ibuprofen on reducing eye pain and migraine headaches caused by trochleitis.""?",False, -23500890,Ibuprofen affects adult acute respiratory distress syndrome,36,"Ibuprofen suppresses the production of various pro-inflammatory cytokines that are implicated in the ""cytokine storm"" and subsequent ARDS in COVID-19 disease.","Is the triple ""Ibuprofen affects adult acute respiratory distress syndrome"" supported by the sentence: ""Ibuprofen suppresses the production of various pro-inflammatory cytokines that are implicated in the ""cytokine storm"" and subsequent ARDS in COVID-19 disease.""?",False, -21214366,Ibuprofen affects bronchopulmonary dysplasia,37,"After adjusting for covariates, the risk of BPD was associated independently with ibuprofen exposure (odds ratios (OR) 2.296, 95% confidence interval (CI): 1.166-4.522, p = 0.016).","Is the triple ""Ibuprofen affects bronchopulmonary dysplasia"" supported by the sentence: ""After adjusting for covariates, the risk of BPD was associated independently with ibuprofen exposure (odds ratios (OR) 2.296, 95% confidence interval (CI): 1.166-4.522, p = 0.016).""?",False, -20886939,Ibuprofen affects Cognitive impairment,38,The opposite effect of ibuprofen on ethanol-induced cognitive impairment as measured by two lateralized functions is consistent with the reports in tissue and animal models that central nervous system effects of ethanol may be mediated at least in part by prostaglandins.,"Is the triple ""Ibuprofen affects Cognitive impairment"" supported by the sentence: ""The opposite effect of ibuprofen on ethanol-induced cognitive impairment as measured by two lateralized functions is consistent with the reports in tissue and animal models that central nervous system effects of ethanol may be mediated at least in part by prostaglandins.""?",False, -18977843,Ibuprofen affects Headache,39,"On post-partum day five, she began complaining of headaches, initially responsive to ibuprofen but eventually worsened with no relief.","Is the triple ""Ibuprofen affects Headache"" supported by the sentence: ""On post-partum day five, she began complaining of headaches, initially responsive to ibuprofen but eventually worsened with no relief.""?",False, -15746938,Ibuprofen affects injury,40,"Because ibuprofen protects from septic lung injury, we studied the effect of ibuprofen in oxidant lung injury from phosgene.","Is the triple ""Ibuprofen affects injury"" supported by the sentence: ""Because ibuprofen protects from septic lung injury, we studied the effect of ibuprofen in oxidant lung injury from phosgene.""?",False, -13826486,Ibuprofen affects osteoarthritis,41,The efficacy and tolerance of ibuprofen retard at a dose of 2 x 800 mg daily was investigated in an open multicenter study over a period of 3 weeks on 7931 out-patients with activated degenerative joint disease and/or extraarticular rheumatic symptoms.,"Is the triple ""Ibuprofen affects osteoarthritis"" supported by the sentence: ""The efficacy and tolerance of ibuprofen retard at a dose of 2 x 800 mg daily was investigated in an open multicenter study over a period of 3 weeks on 7931 out-patients with activated degenerative joint disease and/or extraarticular rheumatic symptoms.""?",False, -13584223,Ibuprofen affects Cognitive impairment,42,"Overall, we found no relation between regular aspirin use and cognitive decline, but long-term use of ibuprofen may be related to decreased rates of cognitive decline in older persons.","Is the triple ""Ibuprofen affects Cognitive impairment"" supported by the sentence: ""Overall, we found no relation between regular aspirin use and cognitive decline, but long-term use of ibuprofen may be related to decreased rates of cognitive decline in older persons.""?",False, -12659717,Ibuprofen affects Fever,43,"Subdiaphragmatic vagotomy or 7-nitroindazole reduced, icatibant, DALBK, IL-1ra, aminoguanidine and dipyrone abolished, while ibuprofen and celecoxib failed to affect Tsv-induced fever.","Is the triple ""Ibuprofen affects Fever"" supported by the sentence: ""Subdiaphragmatic vagotomy or 7-nitroindazole reduced, icatibant, DALBK, IL-1ra, aminoguanidine and dipyrone abolished, while ibuprofen and celecoxib failed to affect Tsv-induced fever.""?",False, -11207850,Ibuprofen affects peptic ulcer disease,44,Reduced incidence of gastroduodenal ulcers associated with lumiracoxib compared with ibuprofen in patients with rheumatoid arthritis.,"Is the triple ""Ibuprofen affects peptic ulcer disease"" supported by the sentence: ""Reduced incidence of gastroduodenal ulcers associated with lumiracoxib compared with ibuprofen in patients with rheumatoid arthritis.""?",False, -11159990,Ibuprofen affects Hemorrhage,45,It was also investigated whether the use of ibuprofen or paracetamol would influence the amount of surgical bleeding.,"Is the triple ""Ibuprofen affects Hemorrhage"" supported by the sentence: ""It was also investigated whether the use of ibuprofen or paracetamol would influence the amount of surgical bleeding.""?",False, -10170540,Ibuprofen affects patent ductus arteriosus,46,"In a randomised, placebo-controlled, double-blind trial of prophylaxis with ibuprofen, the rate of patent ductus arteriosus associated with ibuprofen was 19% compared with 42% with placebo.","Is the triple ""Ibuprofen affects patent ductus arteriosus"" supported by the sentence: ""In a randomised, placebo-controlled, double-blind trial of prophylaxis with ibuprofen, the rate of patent ductus arteriosus associated with ibuprofen was 19% compared with 42% with placebo.""?",False, -10026104,Ibuprofen affects Myalgia,47,"The purpose of this study was to examine the effects of ibuprofen on delayed onset muscle soreness (DOMS), indirect markers of muscle damage and muscular performance.","Is the triple ""Ibuprofen affects Myalgia"" supported by the sentence: ""The purpose of this study was to examine the effects of ibuprofen on delayed onset muscle soreness (DOMS), indirect markers of muscle damage and muscular performance.""?",False, -9889792,Ibuprofen affects Hemorrhage,48,CONCLUSIONS: Pretreatment with ibuprofen before elective total hip surgery increases the perioperative blood loss significantly.,"Is the triple ""Ibuprofen affects Hemorrhage"" supported by the sentence: ""CONCLUSIONS: Pretreatment with ibuprofen before elective total hip surgery increases the perioperative blood loss significantly.""?",False, -8819538,Ibuprofen affects osteoarthritis,49,"The data suggest that nimesulide and ibuprofen, in addition to their anti-inflammatory and analgesic benefits, may also have a protective effect in osteoarthritis through the inhibition of apoptosis in chondrocytes.","Is the triple ""Ibuprofen affects osteoarthritis"" supported by the sentence: ""The data suggest that nimesulide and ibuprofen, in addition to their anti-inflammatory and analgesic benefits, may also have a protective effect in osteoarthritis through the inhibition of apoptosis in chondrocytes.""?",False, -8421263,Ibuprofen affects Fever,50,Pretreatment with ibuprofen blocked the fever induced by RANTES.,"Is the triple ""Ibuprofen affects Fever"" supported by the sentence: ""Pretreatment with ibuprofen blocked the fever induced by RANTES.""?",False, -27630106,Ibuprofen disrupts Acute Pain,51,This study evaluated whether administration of the pharmacologically active S(+)-isomer of ibuprofen suppresses acute pain and plasma beta-endorphin levels in the oral surgery model of acute pain.,"Is the triple ""Ibuprofen disrupts Acute Pain"" supported by the sentence: ""This study evaluated whether administration of the pharmacologically active S(+)-isomer of ibuprofen suppresses acute pain and plasma beta-endorphin levels in the oral surgery model of acute pain.""?",False, -23399675,Ibuprofen disrupts Myalgia,52,"On the other hand, in subgroup B, no improvement in flexibility or reduction in muscle soreness was found in patients who took ibuprofen.","Is the triple ""Ibuprofen disrupts Myalgia"" supported by the sentence: ""On the other hand, in subgroup B, no improvement in flexibility or reduction in muscle soreness was found in patients who took ibuprofen.""?",False, -18599970,Ibuprofen disrupts arthritic joint disease,53,"This is termed, Celery Seed Extract (CSE) and has been found to be at least as effective as aspirin, ibuprofen, and naproxen in suppressing arthritis in a model of polyarthritis.","Is the triple ""Ibuprofen disrupts arthritic joint disease"" supported by the sentence: ""This is termed, Celery Seed Extract (CSE) and has been found to be at least as effective as aspirin, ibuprofen, and naproxen in suppressing arthritis in a model of polyarthritis.""?",False, -15072611,Ibuprofen disrupts Fever,54,INTRODUCTION: Hospitalized patients are often unable to ingest or tolerate oral antipyretics and recently an aqueous formulation of intravenous (IV) ibuprofen was approved by the US-FDA for the reduction of fever in adults.,"Is the triple ""Ibuprofen disrupts Fever"" supported by the sentence: ""INTRODUCTION: Hospitalized patients are often unable to ingest or tolerate oral antipyretics and recently an aqueous formulation of intravenous (IV) ibuprofen was approved by the US-FDA for the reduction of fever in adults.""?",False, -14486259,Ibuprofen disrupts Pain,55,"OBJECTIVES: This study compared the analgesic effectiveness of acetaminophen-codeine with that of ibuprofen for children with acute traumatic extremity pain, with the hypothesis that the two medications would demonstrate equivalent reduction in pain scores in an emergency department (ED) setting.","Is the triple ""Ibuprofen disrupts Pain"" supported by the sentence: ""OBJECTIVES: This study compared the analgesic effectiveness of acetaminophen-codeine with that of ibuprofen for children with acute traumatic extremity pain, with the hypothesis that the two medications would demonstrate equivalent reduction in pain scores in an emergency department (ED) setting.""?",False, -8331095,Ibuprofen disrupts Alzheimer disease,56,"Thus, the anti-inflammatory drug ibuprofen, which has been associated with reduced AD risk in human epidemiological studies, can significantly delay some forms of AD pathology, including amyloid deposition, when administered early in the disease course of a transgenic mouse model of AD.","Is the triple ""Ibuprofen disrupts Alzheimer disease"" supported by the sentence: ""Thus, the anti-inflammatory drug ibuprofen, which has been associated with reduced AD risk in human epidemiological studies, can significantly delay some forms of AD pathology, including amyloid deposition, when administered early in the disease course of a transgenic mouse model of AD.""?",False, -25657729,Ibuprofen prevents hypertensive disorder,57,"The hypoxia, hypertension and increased prostanoids were prevented using ibuprofen.","Is the triple ""Ibuprofen prevents hypertensive disorder"" supported by the sentence: ""The hypoxia, hypertension and increased prostanoids were prevented using ibuprofen.""?",False, -22159382,Ibuprofen prevents Hemorrhage,58,"The Effect of Ibuprofen Dosing Interval on Post-Tonsillectomy Outcomes in Children: A Quality Improvement Study.OBJECTIVE: In this Quality Improvement (QI project) it was hypothesized that an increase in dosing intervals for postoperative analgesia when alternating Ibuprofen and Acetaminophen would reduce post-tonsillectomy hemorrhage (PTH) rates for those undergoing tonsillectomies with or without adenoidectomy, while maintaining the standard of postoperative analgesia and reducing visits to the Emergency Room (ER) for reasons other than PTH.","Is the triple ""Ibuprofen prevents Hemorrhage"" supported by the sentence: ""The Effect of Ibuprofen Dosing Interval on Post-Tonsillectomy Outcomes in Children: A Quality Improvement Study.OBJECTIVE: In this Quality Improvement (QI project) it was hypothesized that an increase in dosing intervals for postoperative analgesia when alternating Ibuprofen and Acetaminophen would reduce post-tonsillectomy hemorrhage (PTH) rates for those undergoing tonsillectomies with or without adenoidectomy, while maintaining the standard of postoperative analgesia and reducing visits to the Emergency Room (ER) for reasons other than PTH.""?",False, -22123299,Ibuprofen prevents Fever,59,Studies show that ibuprofen demonstrates superior efficacy in fever reduction compared to acetaminophen.,"Is the triple ""Ibuprofen prevents Fever"" supported by the sentence: ""Studies show that ibuprofen demonstrates superior efficacy in fever reduction compared to acetaminophen.""?",False, -21354514,Ibuprofen prevents pancreatitis,60,IV Ibuprofen for Prevention of Post-Ercp Pancreatitis in Children: A Randomized Placebo-Controlled Feasibility Study.,"Is the triple ""Ibuprofen prevents pancreatitis"" supported by the sentence: ""IV Ibuprofen for Prevention of Post-Ercp Pancreatitis in Children: A Randomized Placebo-Controlled Feasibility Study.""?",False, -20691057,Ibuprofen prevents altitude sickness,61,Altitude Sickness Prevention with Ibuprofen Relative to Acetazolamide.,"Is the triple ""Ibuprofen prevents altitude sickness"" supported by the sentence: ""Altitude Sickness Prevention with Ibuprofen Relative to Acetazolamide.""?",False, -19399624,Ibuprofen prevents osteoarthritis,62,"In conclusion, prednisone, ibuprofen and betamethasone may prevent OA by suppressing the expression of IL-6 and IL-8, subsequently inactivating NF-kappaB and STAT3 pathways, and ultimately, leading to decreased levels of collagen I, MMP-1, and MMP-13.","Is the triple ""Ibuprofen prevents osteoarthritis"" supported by the sentence: ""In conclusion, prednisone, ibuprofen and betamethasone may prevent OA by suppressing the expression of IL-6 and IL-8, subsequently inactivating NF-kappaB and STAT3 pathways, and ultimately, leading to decreased levels of collagen I, MMP-1, and MMP-13.""?",False, -17687542,Ibuprofen prevents canker sore,63,"This study aims to determine the therapeutic effects of ibuprofen, diphenhydramine and aluminum magnesium simethicone (AlMgS) syrup on reducing oral aphthous ulcer pain.","Is the triple ""Ibuprofen prevents canker sore"" supported by the sentence: ""This study aims to determine the therapeutic effects of ibuprofen, diphenhydramine and aluminum magnesium simethicone (AlMgS) syrup on reducing oral aphthous ulcer pain.""?",False, -15961024,Ibuprofen prevents Dysmenorrhea,64,"CONCLUSIONS: Considering the results of the study, reflexology was superior to Ibuprofen on reducing dysmenorrhea and its treatment effect continued even after discontinuing the intervention in the third cycle.","Is the triple ""Ibuprofen prevents Dysmenorrhea"" supported by the sentence: ""CONCLUSIONS: Considering the results of the study, reflexology was superior to Ibuprofen on reducing dysmenorrhea and its treatment effect continued even after discontinuing the intervention in the third cycle.""?",False, -13710734,Ibuprofen prevents Chronic pain,65,CONCLUSION: We conclude that pain therapy with an almost peripherally acting drug such as ibuprofen can reduce osteoporosis-associated chronic pain better than a centrally acting pain medication such as tramadol.,"Is the triple ""Ibuprofen prevents Chronic pain"" supported by the sentence: ""CONCLUSION: We conclude that pain therapy with an almost peripherally acting drug such as ibuprofen can reduce osteoporosis-associated chronic pain better than a centrally acting pain medication such as tramadol.""?",False, -10201705,Ibuprofen prevents Headache,66,The objective of this study was to determine whether pretreatment with ibuprofen would prevent the onset or decrease the severity of headache that occurs after ECT.,"Is the triple ""Ibuprofen prevents Headache"" supported by the sentence: ""The objective of this study was to determine whether pretreatment with ibuprofen would prevent the onset or decrease the severity of headache that occurs after ECT.""?",False, -10026105,Ibuprofen prevents Myalgia,67,The results of this study reveal that intake of ibuprofen can decrease muscle soreness induced after eccentric exercise but cannot assist in restoring muscle function.,"Is the triple ""Ibuprofen prevents Myalgia"" supported by the sentence: ""The results of this study reveal that intake of ibuprofen can decrease muscle soreness induced after eccentric exercise but cannot assist in restoring muscle function.""?",False, -9104502,Ibuprofen prevents injury,68,The objective of our study was to determine the role of ibuprofen in protecting neutropenic rats from cardiopulmonary injury due to endotoxemia.,"Is the triple ""Ibuprofen prevents injury"" supported by the sentence: ""The objective of our study was to determine the role of ibuprofen in protecting neutropenic rats from cardiopulmonary injury due to endotoxemia.""?",False, -9022792,Ibuprofen prevents Pain,69,"To determine if prophylactic etodolac would significantly reduce postendodontic pain, when compared with ibuprofen or placebo, 36 patients consented to single blind oral administration of either 400 mg of etodolac, 600 mg of ibuprofen, or a placebo, before conventional one-appointment root canal therapy.","Is the triple ""Ibuprofen prevents Pain"" supported by the sentence: ""To determine if prophylactic etodolac would significantly reduce postendodontic pain, when compared with ibuprofen or placebo, 36 patients consented to single blind oral administration of either 400 mg of etodolac, 600 mg of ibuprofen, or a placebo, before conventional one-appointment root canal therapy.""?",False, -8584177,Ibuprofen prevents patent ductus arteriosus,70,UNLABELLED: The aim of our study was to evaluate whether the prophylactic use of ibuprofen would reduce the incidence of significant patent ductus arteriosus (PDA) and to confirm the effectiveness of ibuprofen as rescue treatment in closing PDA.,"Is the triple ""Ibuprofen prevents patent ductus arteriosus"" supported by the sentence: ""UNLABELLED: The aim of our study was to evaluate whether the prophylactic use of ibuprofen would reduce the incidence of significant patent ductus arteriosus (PDA) and to confirm the effectiveness of ibuprofen as rescue treatment in closing PDA.""?",False, -7843138,Ibuprofen prevents Alzheimer disease,71,"Nonsteroidal anti-inflammatory drugs (NSAIDs) such as aspirin, indomethacin and ibuprofen are the most widely used drugs for pain, arthritis, cardiovascular diseases and, more recently, the prevention of colon cancer and Alzheimer disease.","Is the triple ""Ibuprofen prevents Alzheimer disease"" supported by the sentence: ""Nonsteroidal anti-inflammatory drugs (NSAIDs) such as aspirin, indomethacin and ibuprofen are the most widely used drugs for pain, arthritis, cardiovascular diseases and, more recently, the prevention of colon cancer and Alzheimer disease.""?",False, -15342704,Ibuprofen exacerbates injury,72,Aggravation of seizure-associated microvascular injuries by ibuprofen may involve multiple pathways.,"Is the triple ""Ibuprofen exacerbates injury"" supported by the sentence: ""Aggravation of seizure-associated microvascular injuries by ibuprofen may involve multiple pathways.""?",False, -20007370,Ibuprofen predisposes cerebral palsy,73,"Use of paracetamol, ibuprofen or aspirin in pregnancy and risk of cerebral palsy in the child.","Is the triple ""Ibuprofen predisposes cerebral palsy"" supported by the sentence: ""Use of paracetamol, ibuprofen or aspirin in pregnancy and risk of cerebral palsy in the child.""?",False, -14332005,Ibuprofen predisposes bronchopulmonary dysplasia,74,"More than two cycles of ibuprofen was significantly associated with an increased risk for bronchopulmonary dysplasia (odds ratio [OR], 2.81; p = 0.03) and acute renal failure (OR, 3.81; p = 0.09).","Is the triple ""Ibuprofen predisposes bronchopulmonary dysplasia"" supported by the sentence: ""More than two cycles of ibuprofen was significantly associated with an increased risk for bronchopulmonary dysplasia (odds ratio [OR], 2.81; p = 0.03) and acute renal failure (OR, 3.81; p = 0.09).""?",False, -14294004,Ibuprofen predisposes Alzheimer disease,75,OBJECTIVE: Non-steroidal anti-inflammatory drugs such as ibuprofen have a protective role on risk of Alzheimer's disease (AD).,"Is the triple ""Ibuprofen predisposes Alzheimer disease"" supported by the sentence: ""OBJECTIVE: Non-steroidal anti-inflammatory drugs such as ibuprofen have a protective role on risk of Alzheimer's disease (AD).""?",False, -14085648,Ibuprofen predisposes injury,76,"There seems to be a marked gradient of risk for acute kidney injury across agents, specifically for indomethacin, ibuprofen, and rofecoxib.","Is the triple ""Ibuprofen predisposes injury"" supported by the sentence: ""There seems to be a marked gradient of risk for acute kidney injury across agents, specifically for indomethacin, ibuprofen, and rofecoxib.""?",False, -12673407,Ibuprofen predisposes bone fracture,77,"Significant heterogeneity was present for the NSAIDs; e.g., ibuprofen was associated with an increased overall fracture risk (OR = 2.09, 95% CI 2.00-2.18 for <20 DDD), while celecoxib was not (OR = 0.76, 95% CI 0.51-1.13 for <20 DDD, 2P < 0.01 for comparison).","Is the triple ""Ibuprofen predisposes bone fracture"" supported by the sentence: ""Significant heterogeneity was present for the NSAIDs; e.g., ibuprofen was associated with an increased overall fracture risk (OR = 2.09, 95% CI 2.00-2.18 for <20 DDD), while celecoxib was not (OR = 0.76, 95% CI 0.51-1.13 for <20 DDD, 2P < 0.01 for comparison).""?",False, -17604344,Ivabradine related to diastolic heart failure,78,One should be more critical about ivabradine and low-dose digoxin in diastolic heart failure.,"Is the triple ""Ivabradine related to diastolic heart failure"" supported by the sentence: ""One should be more critical about ivabradine and low-dose digoxin in diastolic heart failure.""?",False, -19228519,Ivabradine causes atrial fibrillation,79,"Preclinical studies of ivabradine in animal models with induced AF demonstrated a reduction in HR, with no significant worsening of QT interval or mean arterial pressure.","Is the triple ""Ivabradine causes atrial fibrillation"" supported by the sentence: ""Preclinical studies of ivabradine in animal models with induced AF demonstrated a reduction in HR, with no significant worsening of QT interval or mean arterial pressure.""?",False, -20784958,Ivabradine affects atrial fibrillation,80,"In this review, we summarize the current knowledge of the HCN4 channel and ivabradine, including the function of HCN4 in cardiac pacemaking, the mechanism of action of If inhibition by ivabradine, and the pharmacological and clinical effects of ivabradine in cardiac diseases as HF, coronary artery disease, and atrial fibrillation.","Is the triple ""Ivabradine affects atrial fibrillation"" supported by the sentence: ""In this review, we summarize the current knowledge of the HCN4 channel and ivabradine, including the function of HCN4 in cardiac pacemaking, the mechanism of action of If inhibition by ivabradine, and the pharmacological and clinical effects of ivabradine in cardiac diseases as HF, coronary artery disease, and atrial fibrillation.""?",False, -20520107,Ivabradine affects mitral valve stenosis,81,Small studies have recently investigated the role of ivabradine in MS in sinus rhythm.,"Is the triple ""Ivabradine affects mitral valve stenosis"" supported by the sentence: ""Small studies have recently investigated the role of ivabradine in MS in sinus rhythm.""?",False, -20004006,Ivabradine affects diastolic heart failure,82,The role of Ivabradine in Diastolic Heart Failure with preserved Ejection Fraction.,"Is the triple ""Ivabradine affects diastolic heart failure"" supported by the sentence: ""The role of Ivabradine in Diastolic Heart Failure with preserved Ejection Fraction.""?",False, -15323309,Ivabradine affects cardiovascular disorder,83,"Other large trials are also underway to assess the effects of ivabradine on heart failure, acute coronary syndromes, CAD, and other cardiovascular disorders.","Is the triple ""Ivabradine affects cardiovascular disorder"" supported by the sentence: ""Other large trials are also underway to assess the effects of ivabradine on heart failure, acute coronary syndromes, CAD, and other cardiovascular disorders.""?",False, -15323306,Ivabradine affects coronary artery disorder,84,"Other large trials are also underway to assess the effects of ivabradine on heart failure, acute coronary syndromes, CAD, and other cardiovascular disorders.","Is the triple ""Ivabradine affects coronary artery disorder"" supported by the sentence: ""Other large trials are also underway to assess the effects of ivabradine on heart failure, acute coronary syndromes, CAD, and other cardiovascular disorders.""?",False, -19514713,Ivabradine disrupts atrial fibrillation,85,Effective suppression of atrial fibrillation by ivabradine: Novel target for an established drug?,"Is the triple ""Ivabradine disrupts atrial fibrillation"" supported by the sentence: ""Effective suppression of atrial fibrillation by ivabradine: Novel target for an established drug?""?",False, -17909104,Ivabradine disrupts coronary artery disorder,86,[SIGNIFY study is a disappointment. Ivabradine cannot stop of the progression of coronary heart disease].,"Is the triple ""Ivabradine disrupts coronary artery disorder"" supported by the sentence: ""[SIGNIFY study is a disappointment. Ivabradine cannot stop of the progression of coronary heart disease].""?",False, -17822394,Ivabradine prevents atrial fibrillation,87,RESULTS: Heart rate reduction and prevention of postoperative AF or tachyarrhythmia with combined therapy was more effective than with metoprolol or ivabradine alone during the immediate postoperative management of cardiac surgery patients.,"Is the triple ""Ivabradine prevents atrial fibrillation"" supported by the sentence: ""RESULTS: Heart rate reduction and prevention of postoperative AF or tachyarrhythmia with combined therapy was more effective than with metoprolol or ivabradine alone during the immediate postoperative management of cardiac surgery patients.""?",False, -10817471,Ivabradine prevents Tachycardia,88,"During exercise, ivabradine dose dependently and significantly reduced the exercise-induced tachycardia (-17, -21, and -32% at 0.25, 0.5, and 1 mg/kg, respectively, versus saline) without altering myocardial contractility nor mean ejection wall stress.","Is the triple ""Ivabradine prevents Tachycardia"" supported by the sentence: ""During exercise, ivabradine dose dependently and significantly reduced the exercise-induced tachycardia (-17, -21, and -32% at 0.25, 0.5, and 1 mg/kg, respectively, versus saline) without altering myocardial contractility nor mean ejection wall stress.""?",False, -19153602,Ivabradine predisposes atrial fibrillation,89,Recent trials reported that risk of atrial fibrillation (AF) is increased in patients using ivabradine compared with controls.,"Is the triple ""Ivabradine predisposes atrial fibrillation"" supported by the sentence: ""Recent trials reported that risk of atrial fibrillation (AF) is increased in patients using ivabradine compared with controls.""?",False, -15385004,Cefixime affects chronic bronchitis,90,Randomized comparative study of cefixime versus cephalexin in acute bacterial exacerbations of chronic bronchitis.,"Is the triple ""Cefixime affects chronic bronchitis"" supported by the sentence: ""Randomized comparative study of cefixime versus cephalexin in acute bacterial exacerbations of chronic bronchitis.""?",False, -15252860,Cefixime affects gonorrhea,91,Alterations of the pilQ gene in Neisseria gonorrhoeae are unlikely contributors to decreased susceptibility to ceftriaxone and cefixime in clinical gonococcal strains.,"Is the triple ""Cefixime affects gonorrhea"" supported by the sentence: ""Alterations of the pilQ gene in Neisseria gonorrhoeae are unlikely contributors to decreased susceptibility to ceftriaxone and cefixime in clinical gonococcal strains.""?",False, -18811968,Cefixime prevents otitis media,92,"Because of the emergence of these bacteria, other antimicrobial agents, both old and new, have been advocated for treatment and prevention of otitis media; amoxicillin-clavulanate, cefuroxime axetil, and cefixime are the newer agents.","Is the triple ""Cefixime prevents otitis media"" supported by the sentence: ""Because of the emergence of these bacteria, other antimicrobial agents, both old and new, have been advocated for treatment and prevention of otitis media; amoxicillin-clavulanate, cefuroxime axetil, and cefixime are the newer agents.""?",False, -17748395,Trimetazidine related to diabetic kidney disease,93,Experimental comparison of protective characteristics of enalapril and trimetazidine in diabetic nephropathy.,"Is the triple ""Trimetazidine related to diabetic kidney disease"" supported by the sentence: ""Experimental comparison of protective characteristics of enalapril and trimetazidine in diabetic nephropathy.""?",False, -22426756,Trimetazidine affects diabetic kidney disease,94,This study aimed to investigate the role of TMZ in diabetic nephropathy (DN) and its potential mechanisms.,"Is the triple ""Trimetazidine affects diabetic kidney disease"" supported by the sentence: ""This study aimed to investigate the role of TMZ in diabetic nephropathy (DN) and its potential mechanisms.""?",False, -21297588,Trimetazidine affects Cardiotoxicity,95,Objective: This study investigates the effect of TMZ in sunitinib-induced cardiotoxicity in vivo and in vitro and molecular mechanisms.,"Is the triple ""Trimetazidine affects Cardiotoxicity"" supported by the sentence: ""Objective: This study investigates the effect of TMZ in sunitinib-induced cardiotoxicity in vivo and in vitro and molecular mechanisms.""?",False, -19164679,Trimetazidine affects cardiovascular disorder,96,The role of trimetazidine in cardiovascular disease: beyond an anti-anginal agent.,"Is the triple ""Trimetazidine affects cardiovascular disorder"" supported by the sentence: ""The role of trimetazidine in cardiovascular disease: beyond an anti-anginal agent.""?",False, -18547788,Trimetazidine prevents Cardiotoxicity,97,"Trimetazidine, 2.5 mg/kg/day i.p. for 3 days before doxorubicin administration plus 2.5 mg/kg/day p.o. for 10 weeks, was unable to prevent the development of doxorubicin-induced long-term cardiotoxicity.","Is the triple ""Trimetazidine prevents Cardiotoxicity"" supported by the sentence: ""Trimetazidine, 2.5 mg/kg/day i.p. for 3 days before doxorubicin administration plus 2.5 mg/kg/day p.o. for 10 weeks, was unable to prevent the development of doxorubicin-induced long-term cardiotoxicity.""?",False, -13317799,Ranolazine causes atrial fibrillation,98,Ranolazine was more effective than lidocaine in terminating persistent AF and in preventing the induction of AF.,"Is the triple ""Ranolazine causes atrial fibrillation"" supported by the sentence: ""Ranolazine was more effective than lidocaine in terminating persistent AF and in preventing the induction of AF.""?",False, -19314329,Ranolazine affects cardiovascular disorder,99,Role of Ranolazine in cardiovascular disease and diabetes: Exploring beyond angina.,"Is the triple ""Ranolazine affects cardiovascular disorder"" supported by the sentence: ""Role of Ranolazine in cardiovascular disease and diabetes: Exploring beyond angina.""?",False, -19002641,Ranolazine affects atrial fibrillation,100,"Furthermore, the activated Akt/mTOR signaling pathway induced by AF was further activated by ranolazine.","Is the triple ""Ranolazine affects atrial fibrillation"" supported by the sentence: ""Furthermore, the activated Akt/mTOR signaling pathway induced by AF was further activated by ranolazine.""?",False, -17881291,Ranolazine affects type 2 diabetes mellitus,101,Recent evidence of beneficial effects of ranolazine (RAN) in type II diabetes motivates interest in the role of the late sodium current (INaL) in glucose-stimulated insulin secretion.,"Is the triple ""Ranolazine affects type 2 diabetes mellitus"" supported by the sentence: ""Recent evidence of beneficial effects of ranolazine (RAN) in type II diabetes motivates interest in the role of the late sodium current (INaL) in glucose-stimulated insulin secretion.""?",False, -16599546,Ranolazine affects atrial fibrillation,102,Effect of ranolazine in preventing postoperative atrial fibrillation in patients undergoing coronary revascularization surgery.,"Is the triple ""Ranolazine affects atrial fibrillation"" supported by the sentence: ""Effect of ranolazine in preventing postoperative atrial fibrillation in patients undergoing coronary revascularization surgery.""?",False, -15199166,Ranolazine affects myocardial ischemia,103,The anti-ischemic mechanism of action of ranolazine in stable ischemic heart disease.,"Is the triple ""Ranolazine affects myocardial ischemia"" supported by the sentence: ""The anti-ischemic mechanism of action of ranolazine in stable ischemic heart disease.""?",False, -13887428,Ranolazine disrupts atrial fibrillation,104,Atrial-selective/predominant sodium channel blockers such as ranolazine effectively suppress AF in experimental models of AF involving canine isolated right atrial preparations at concentrations that produce little to no effect on ventricular electrophysiologic parameters.,"Is the triple ""Ranolazine disrupts atrial fibrillation"" supported by the sentence: ""Atrial-selective/predominant sodium channel blockers such as ranolazine effectively suppress AF in experimental models of AF involving canine isolated right atrial preparations at concentrations that produce little to no effect on ventricular electrophysiologic parameters.""?",False, -17475563,Ranolazine prevents Angina pectoris,105,Ranolazine has been shown to decrease angina pectoris frequency and nitroglycerin consumption.,"Is the triple ""Ranolazine prevents Angina pectoris"" supported by the sentence: ""Ranolazine has been shown to decrease angina pectoris frequency and nitroglycerin consumption.""?",False, -14751648,Ranolazine prevents myocardial ischemia,106,BACKGROUND: Ranolazine has been shown to reduce myocardial ischemia and symptom severity among selected patients with chronic angina.,"Is the triple ""Ranolazine prevents myocardial ischemia"" supported by the sentence: ""BACKGROUND: Ranolazine has been shown to reduce myocardial ischemia and symptom severity among selected patients with chronic angina.""?",False, -14280230,Ranolazine prevents atrial fibrillation,107,"Dominant frequency (DF) of AF was reduced by ranolazine in left atrium from 11.7 (10.7-20.5) Hz to 7.6 (2.9-8.8) Hz (P = 0.02, n = 6).","Is the triple ""Ranolazine prevents atrial fibrillation"" supported by the sentence: ""Dominant frequency (DF) of AF was reduced by ranolazine in left atrium from 11.7 (10.7-20.5) Hz to 7.6 (2.9-8.8) Hz (P = 0.02, n = 6).""?",False, -17988674,Ranolazine predisposes atrial fibrillation,108,"After adjusting for potential sources of bias through propensity-score matched-pair analysis and conditional logistic regression, ranolazine was an independent predictor of preventing POAF (p < 0.0001).","Is the triple ""Ranolazine predisposes atrial fibrillation"" supported by the sentence: ""After adjusting for potential sources of bias through propensity-score matched-pair analysis and conditional logistic regression, ranolazine was an independent predictor of preventing POAF (p < 0.0001).""?",False, -26862829,Prednisolone related to multiple sclerosis,109,Prednisolone furthers T-cell immunodeficiency and also reduces the intensity of autoimmune reactions in multiple sclerosis.,"Is the triple ""Prednisolone related to multiple sclerosis"" supported by the sentence: ""Prednisolone furthers T-cell immunodeficiency and also reduces the intensity of autoimmune reactions in multiple sclerosis.""?",False, -26365803,Prednisolone related to adrenocortical insufficiency,110,[Pharmacokinetics of prednisolone in adrenal insufficiency ].,"Is the triple ""Prednisolone related to adrenocortical insufficiency"" supported by the sentence: ""[Pharmacokinetics of prednisolone in adrenal insufficiency ].""?",False, -26295217,Prednisolone related to angioimmunoblastic T-cell lymphoma,111,It is concluded that VAP is effective therapy in AIL.,"Is the triple ""Prednisolone related to angioimmunoblastic T-cell lymphoma"" supported by the sentence: ""It is concluded that VAP is effective therapy in AIL.""?",False, -26194122,Prednisolone related to synovitis,112,A thermographic assessment of three intra-articular prednisolone analogues given in rheumatoid synovitis.,"Is the triple ""Prednisolone related to synovitis"" supported by the sentence: ""A thermographic assessment of three intra-articular prednisolone analogues given in rheumatoid synovitis.""?",False, -25959730,Prednisolone related to sarcoma,113,The effect of small doses of prednisolone on the incidence of subcutaneous sarcomas induced by 3-methylcholanthrene in virgin female Swiss mice.,"Is the triple ""Prednisolone related to sarcoma"" supported by the sentence: ""The effect of small doses of prednisolone on the incidence of subcutaneous sarcomas induced by 3-methylcholanthrene in virgin female Swiss mice.""?",False, -25621708,Prednisolone related to uveitis,114,[Effects of chromocarb diethylamine and prednisolone in experimental uveitis induced by clove oil in rabbits].,"Is the triple ""Prednisolone related to uveitis"" supported by the sentence: ""[Effects of chromocarb diethylamine and prednisolone in experimental uveitis induced by clove oil in rabbits].""?",False, -24523226,Prednisolone related to glomerulonephritis,115,[Effect of prednisolone and heparin on circulating T- and B-lymphocytes in glomerulonephritis and systemic lupus erythematosus].,"Is the triple ""Prednisolone related to glomerulonephritis"" supported by the sentence: ""[Effect of prednisolone and heparin on circulating T- and B-lymphocytes in glomerulonephritis and systemic lupus erythematosus].""?",False, -23496152,Prednisolone related to subacute thyroiditis,116,[Effects of prednisolone on thyroidal-123I uptake in subacute thyroiditis].,"Is the triple ""Prednisolone related to subacute thyroiditis"" supported by the sentence: ""[Effects of prednisolone on thyroidal-123I uptake in subacute thyroiditis].""?",False, -22194722,Prednisolone related to pulmonary eosinophilia,117,"Blood Eosinophil Depletion with Mepolizumab, Benralizumab and Prednisolone in Eosinophilic Asthma.","Is the triple ""Prednisolone related to pulmonary eosinophilia"" supported by the sentence: ""Blood Eosinophil Depletion with Mepolizumab, Benralizumab and Prednisolone in Eosinophilic Asthma.""?",False, -21911849,Prednisolone related to habitual spontaneous abortion,118,[Prednisolone and aspirin combination therapy in habitual abortion with autoantibodies].,"Is the triple ""Prednisolone related to habitual spontaneous abortion"" supported by the sentence: ""[Prednisolone and aspirin combination therapy in habitual abortion with autoantibodies].""?",False, -20512112,Prednisolone related to castration-resistant prostate carcinoma,119,"To illustrate this, we used an example of cost-effectiveness analysis for docetaxel in combination with prednisolone in metastatic hormone-refractory prostate cancer.","Is the triple ""Prednisolone related to castration-resistant prostate carcinoma"" supported by the sentence: ""To illustrate this, we used an example of cost-effectiveness analysis for docetaxel in combination with prednisolone in metastatic hormone-refractory prostate cancer.""?",False, -20312000,Prednisolone related to chronic primary adrenal insufficiency,120,Prednisolone is associated with a worse bone mineral density in primary adrenal insufficiency.,"Is the triple ""Prednisolone related to chronic primary adrenal insufficiency"" supported by the sentence: ""Prednisolone is associated with a worse bone mineral density in primary adrenal insufficiency.""?",False, -20106181,Prednisolone related to allergic bronchopulmonary aspergillosis,121,CONCLUSIONS: Prednisolone was more effective in inducing response than itraconazole in acute-stage ABPA.,"Is the triple ""Prednisolone related to allergic bronchopulmonary aspergillosis"" supported by the sentence: ""CONCLUSIONS: Prednisolone was more effective in inducing response than itraconazole in acute-stage ABPA.""?",False, -19750187,Prednisolone related to lymphoma,122,"Purpose: The aim of this study was to compare asparaginase-related toxicities in two asparaginase preparations, namely native Escherichia coli L-asparaginase (L-ASP) and pegylated asparaginase (PEG-ASP) in combination with ifosfamide, methotrexate, etoposide, and prednisolone (IMEP) in natural killer (NK)/T-cell lymphoma (NTCL).","Is the triple ""Prednisolone related to lymphoma"" supported by the sentence: ""Purpose: The aim of this study was to compare asparaginase-related toxicities in two asparaginase preparations, namely native Escherichia coli L-asparaginase (L-ASP) and pegylated asparaginase (PEG-ASP) in combination with ifosfamide, methotrexate, etoposide, and prednisolone (IMEP) in natural killer (NK)/T-cell lymphoma (NTCL).""?",False, -17143213,Prednisolone related to temporal arteritis,123,Prednisolone combined with adjunctive immunosuppression is not superior to prednisolone alone in terms of efficacy and safety in giant cell arteritis: meta-analysis.,"Is the triple ""Prednisolone related to temporal arteritis"" supported by the sentence: ""Prednisolone combined with adjunctive immunosuppression is not superior to prednisolone alone in terms of efficacy and safety in giant cell arteritis: meta-analysis.""?",False, -16983852,Prednisolone related to Hodgkins lymphoma,124,CONCLUSION: GVP is well-tolerated regimen with high response rate and needs to be tested in late relapsed HL.,"Is the triple ""Prednisolone related to Hodgkins lymphoma"" supported by the sentence: ""CONCLUSION: GVP is well-tolerated regimen with high response rate and needs to be tested in late relapsed HL.""?",False, -16960031,Prednisolone related to psoriatic arthritis,125,Early treatment with addition of low dose prednisolone to methotrexate improves therapeutic outcome in severe psoriatic arthritis.,"Is the triple ""Prednisolone related to psoriatic arthritis"" supported by the sentence: ""Early treatment with addition of low dose prednisolone to methotrexate improves therapeutic outcome in severe psoriatic arthritis.""?",False, -16502712,Prednisolone related to aplastic anemia,126,"CONCLUSION: Flu/Cy/ATG conditioning regimen, bone marrow as stem cell source and CSA, prednisolone and short methotrexate regimen were associated with better survival in AA.","Is the triple ""Prednisolone related to aplastic anemia"" supported by the sentence: ""CONCLUSION: Flu/Cy/ATG conditioning regimen, bone marrow as stem cell source and CSA, prednisolone and short methotrexate regimen were associated with better survival in AA.""?",False, -16371065,Prednisolone related to celiac disease,127,Effect of addition of short course of prednisolone to gluten-free diet on mucosal epithelial cell regeneration and apoptosis in celiac disease: a pilot randomized controlled trial.,"Is the triple ""Prednisolone related to celiac disease"" supported by the sentence: ""Effect of addition of short course of prednisolone to gluten-free diet on mucosal epithelial cell regeneration and apoptosis in celiac disease: a pilot randomized controlled trial.""?",False, -16192798,Prednisolone related to dermatomyositis,128,Coadministration of cyclosporin a with prednisolone in acute interstitial pneumonia complicating polymyositis/dermatomyositis.,"Is the triple ""Prednisolone related to dermatomyositis"" supported by the sentence: ""Coadministration of cyclosporin a with prednisolone in acute interstitial pneumonia complicating polymyositis/dermatomyositis.""?",False, -16169223,Prednisolone related to mucocutaneous lymph node syndrome,129,"Efficacy of immunoglobulin plus prednisolone for prevention of coronary artery abnormalities in severe Kawasaki disease (RAISE study): a randomised, open-label, blinded-endpoints trial.","Is the triple ""Prednisolone related to mucocutaneous lymph node syndrome"" supported by the sentence: ""Efficacy of immunoglobulin plus prednisolone for prevention of coronary artery abnormalities in severe Kawasaki disease (RAISE study): a randomised, open-label, blinded-endpoints trial.""?",False, -16114172,Prednisolone related to plasma cell myeloma,130,"Response of vincristine, melphalan, cyclophosphamide and prednisolone in refractory multiple myeloma.","Is the triple ""Prednisolone related to plasma cell myeloma"" supported by the sentence: ""Response of vincristine, melphalan, cyclophosphamide and prednisolone in refractory multiple myeloma.""?",False, -14564343,Prednisolone related to acute lymphoblastic leukemia,131,Pyruvate kinase M2 and prednisolone resistance in acute lymphoblastic leukemia.,"Is the triple ""Prednisolone related to acute lymphoblastic leukemia"" supported by the sentence: ""Pyruvate kinase M2 and prednisolone resistance in acute lymphoblastic leukemia.""?",False, -13988965,Prednisolone related to osteoarthritis,132,"Stimulation with prednisolone and TNFalpha reduced GDF-5 expression in OA and RA fibroblasts, whereas MTX and IL-1beta revealed minor or no relevant change.","Is the triple ""Prednisolone related to osteoarthritis"" supported by the sentence: ""Stimulation with prednisolone and TNFalpha reduced GDF-5 expression in OA and RA fibroblasts, whereas MTX and IL-1beta revealed minor or no relevant change.""?",False, -13151963,Prednisolone related to diffuse large B-cell lymphoma,133,"A combination of rituximab plus chemotherapy, rituximab+cyclophosphamide+doxorubicin+vincristine+prednisolone (R-CHOP), has the highest efficacy ever described with any chemotherapy in DLBCL and FL.","Is the triple ""Prednisolone related to diffuse large B-cell lymphoma"" supported by the sentence: ""A combination of rituximab plus chemotherapy, rituximab+cyclophosphamide+doxorubicin+vincristine+prednisolone (R-CHOP), has the highest efficacy ever described with any chemotherapy in DLBCL and FL.""?",False, -13151962,Prednisolone related to follicular lymphoma,134,"A combination of rituximab plus chemotherapy, rituximab+cyclophosphamide+doxorubicin+vincristine+prednisolone (R-CHOP), has the highest efficacy ever described with any chemotherapy in DLBCL and FL.","Is the triple ""Prednisolone related to follicular lymphoma"" supported by the sentence: ""A combination of rituximab plus chemotherapy, rituximab+cyclophosphamide+doxorubicin+vincristine+prednisolone (R-CHOP), has the highest efficacy ever described with any chemotherapy in DLBCL and FL.""?",False, -12983495,Prednisolone related to prostate cancer,135,Weekly docetaxel and prednisolone versus prednisolone alone in androgen-independent prostate cancer: a randomized phase II study.,"Is the triple ""Prednisolone related to prostate cancer"" supported by the sentence: ""Weekly docetaxel and prednisolone versus prednisolone alone in androgen-independent prostate cancer: a randomized phase II study.""?",False, -12510603,Prednisolone related to membranous glomerulonephritis,136,Prednisolone and azathioprine in membranous nephropathy: a 10-year follow-up study.,"Is the triple ""Prednisolone related to membranous glomerulonephritis"" supported by the sentence: ""Prednisolone and azathioprine in membranous nephropathy: a 10-year follow-up study.""?",False, -12496746,Prednisolone related to neoplasm,137,"Taken together, the present study points to a strong inhibitory effect of liposomal PLP on tumor angiogenesis by reduction of the intratumoral production of the majority of pro-angiogenic factors studied and direct inhibition of endothelial cell proliferation, which is the result of high prolonged levels of prednisolone in the tumor by liposomal delivery.","Is the triple ""Prednisolone related to neoplasm"" supported by the sentence: ""Taken together, the present study points to a strong inhibitory effect of liposomal PLP on tumor angiogenesis by reduction of the intratumoral production of the majority of pro-angiogenic factors studied and direct inhibition of endothelial cell proliferation, which is the result of high prolonged levels of prednisolone in the tumor by liposomal delivery.""?",False, -12428137,Prednisolone related to croup,138,Prednisolone versus dexamethasone in croup: a randomised equivalence trial.,"Is the triple ""Prednisolone related to croup"" supported by the sentence: ""Prednisolone versus dexamethasone in croup: a randomised equivalence trial.""?",False, -12061894,Prednisolone related to West syndrome,139,Use of ACTH and prednisolone in infantile spasms: experience from a developing country.,"Is the triple ""Prednisolone related to West syndrome"" supported by the sentence: ""Use of ACTH and prednisolone in infantile spasms: experience from a developing country.""?",False, -11663099,Prednisolone related to Crohn disease,140,Bone mineral density in relation to efficacy and side effects of budesonide and prednisolone in Crohn's disease.,"Is the triple ""Prednisolone related to Crohn disease"" supported by the sentence: ""Bone mineral density in relation to efficacy and side effects of budesonide and prednisolone in Crohn's disease.""?",False, -11638013,Prednisolone related to eosinophilic granulomatosis with polyangiitis,141,OBJECTIVE: To examine the safety and efficacy of methotrexate (MTX) plus low-dose prednisolone for induction of remission in non life- or organ-threatening courses and for remission maintenance in Churg-Strauss syndrome (CSS).,"Is the triple ""Prednisolone related to eosinophilic granulomatosis with polyangiitis"" supported by the sentence: ""OBJECTIVE: To examine the safety and efficacy of methotrexate (MTX) plus low-dose prednisolone for induction of remission in non life- or organ-threatening courses and for remission maintenance in Churg-Strauss syndrome (CSS).""?",False, -11213963,Prednisolone related to leprosy,142,OBJECTIVE: To determine whether addition of low dose prednisolone to multidrug treatment can prevent reaction and nerve function impairment in leprosy.,"Is the triple ""Prednisolone related to leprosy"" supported by the sentence: ""OBJECTIVE: To determine whether addition of low dose prednisolone to multidrug treatment can prevent reaction and nerve function impairment in leprosy.""?",False, -11179224,Prednisolone related to alcoholic hepatitis,143,A double-blind randomized controlled trial of infliximab associated with prednisolone in acute alcoholic hepatitis.,"Is the triple ""Prednisolone related to alcoholic hepatitis"" supported by the sentence: ""A double-blind randomized controlled trial of infliximab associated with prednisolone in acute alcoholic hepatitis.""?",False, -11142916,Prednisolone related to lupus nephritis,144,EULAR randomised controlled trial of pulse cyclophosphamide and methylprednisolone versus continuous cyclophosphamide and prednisolone followed by azathioprine and prednisolone in lupus nephritis.,"Is the triple ""Prednisolone related to lupus nephritis"" supported by the sentence: ""EULAR randomised controlled trial of pulse cyclophosphamide and methylprednisolone versus continuous cyclophosphamide and prednisolone followed by azathioprine and prednisolone in lupus nephritis.""?",False, -11037266,Prednisolone related to granulomatosis with polyangiitis,145,OBJECTIVE: To investigate the safety and efficacy of leflunomide plus low-dose prednisolone for the maintenance of remission in Wegener's granulomatosis (WG).,"Is the triple ""Prednisolone related to granulomatosis with polyangiitis"" supported by the sentence: ""OBJECTIVE: To investigate the safety and efficacy of leflunomide plus low-dose prednisolone for the maintenance of remission in Wegener's granulomatosis (WG).""?",False, -11013570,Prednisolone related to leukemia,146,"Treatment with combined therapy of adriamycin, vincristine and prednisolone produced a remission in the leukaemia with complete resolution of the breast mass.","Is the triple ""Prednisolone related to leukemia"" supported by the sentence: ""Treatment with combined therapy of adriamycin, vincristine and prednisolone produced a remission in the leukaemia with complete resolution of the breast mass.""?",False, -10949449,Prednisolone related to polymyalgia rheumatica,147,RESULTS: The average initial dose of prednisolone in polymyalgia rheumatica was 35 mg; 51 of 62 patients were given a starting dose exceeding 15 mg.,"Is the triple ""Prednisolone related to polymyalgia rheumatica"" supported by the sentence: ""RESULTS: The average initial dose of prednisolone in polymyalgia rheumatica was 35 mg; 51 of 62 patients were given a starting dose exceeding 15 mg.""?",False, -10748640,Prednisolone related to infertility disorder,148,[Trans-utero-tubal administration of prednisolone in sterility caused by obstruction of the tubes].,"Is the triple ""Prednisolone related to infertility disorder"" supported by the sentence: ""[Trans-utero-tubal administration of prednisolone in sterility caused by obstruction of the tubes].""?",False, -10744705,"Prednisolone related to dermatitis, atopic",149,[On experiences with a combination preparation from prednisolone and an antihistaminic in dermatology especially in endogenous eczema].,"Is the triple ""Prednisolone related to dermatitis, atopic"" supported by the sentence: ""[On experiences with a combination preparation from prednisolone and an antihistaminic in dermatology especially in endogenous eczema].""?",False, -10736101,Prednisolone related to Graves disease,150,[USE OF PREDNISOLONE IN SOME GRAVE FORMS OF PATHOLOGY OF THE PREMATURE INFANT].,"Is the triple ""Prednisolone related to Graves disease"" supported by the sentence: ""[USE OF PREDNISOLONE IN SOME GRAVE FORMS OF PATHOLOGY OF THE PREMATURE INFANT].""?",False, -10735679,Prednisolone related to kidney disorder,151,[EFFECT OF PREDNISOLONE ON THE CARDIAC ACTIVITY IN LIVER AND KIDNEY DISEASES AND IN RHEUMATISM].,"Is the triple ""Prednisolone related to kidney disorder"" supported by the sentence: ""[EFFECT OF PREDNISOLONE ON THE CARDIAC ACTIVITY IN LIVER AND KIDNEY DISEASES AND IN RHEUMATISM].""?",False, -10715297,Prednisolone related to keratitis,152,"In this limited pilot study, we compared the effect on clinical outcome of treating Pseudomonas keratitis in guinea pigs with prednisolone (a corticosteroid), flurbiprofen (a cyclo-oxygenase inhibitor), nordihydroguaiaretic acid (a lipoxygenase inhibitor), and a leukotriene antagonist, SKF104353 [R-(R*, S*)]-beta-[(2-carboxyethyl) thio-alpha-hydroxy-2-(8-phenyloctyl) benzenepropanoic acid, zinc salt].","Is the triple ""Prednisolone related to keratitis"" supported by the sentence: ""In this limited pilot study, we compared the effect on clinical outcome of treating Pseudomonas keratitis in guinea pigs with prednisolone (a corticosteroid), flurbiprofen (a cyclo-oxygenase inhibitor), nordihydroguaiaretic acid (a lipoxygenase inhibitor), and a leukotriene antagonist, SKF104353 [R-(R*, S*)]-beta-[(2-carboxyethyl) thio-alpha-hydroxy-2-(8-phenyloctyl) benzenepropanoic acid, zinc salt].""?",False, -10703266,Prednisolone related to ulcerative colitis,153,URINARY EXCRETION OF PREDNISOLONE AFTER INTRARECTAL THERAPY IN ULCERATIVE COLITIS.,"Is the triple ""Prednisolone related to ulcerative colitis"" supported by the sentence: ""URINARY EXCRETION OF PREDNISOLONE AFTER INTRARECTAL THERAPY IN ULCERATIVE COLITIS.""?",False, -10687782,Prednisolone related to hepatocellular carcinoma,154,"Male rats treated with either budesonide, prednisolone, or triamcinolone acetonide in drinking water for up to 104 weeks developed slightly increased incidences of basophilic foci, and significantly increased incidences of combined hepatocellular adenomas/carcinomas as compared to controls.","Is the triple ""Prednisolone related to hepatocellular carcinoma"" supported by the sentence: ""Male rats treated with either budesonide, prednisolone, or triamcinolone acetonide in drinking water for up to 104 weeks developed slightly increased incidences of basophilic foci, and significantly increased incidences of combined hepatocellular adenomas/carcinomas as compared to controls.""?",False, -10623724,Prednisolone related to hemolytic anemia,155,[On the use of prednisolone in hemolytic anemia of the newborn caused by fetomaternal Rh-factor incompatibility].,"Is the triple ""Prednisolone related to hemolytic anemia"" supported by the sentence: ""[On the use of prednisolone in hemolytic anemia of the newborn caused by fetomaternal Rh-factor incompatibility].""?",False, -10576837,Prednisolone related to juvenile idiopathic arthritis,156,Long-term use of prednisone and prednisolone in juvenile rheumatoid arthritis; a report of fifteen cases.,"Is the triple ""Prednisolone related to juvenile idiopathic arthritis"" supported by the sentence: ""Long-term use of prednisone and prednisolone in juvenile rheumatoid arthritis; a report of fifteen cases.""?",False, -10565620,Prednisolone related to nephrotic syndrome,157,[Effect of prednisolone and human albumin on protein excretion in nephrotic syndrome].,"Is the triple ""Prednisolone related to nephrotic syndrome"" supported by the sentence: ""[Effect of prednisolone and human albumin on protein excretion in nephrotic syndrome].""?",False, -10531966,Prednisolone related to allergic disease,158,[Therapeutic results of metacortandralone or prednisolone in allergy].,"Is the triple ""Prednisolone related to allergic disease"" supported by the sentence: ""[Therapeutic results of metacortandralone or prednisolone in allergy].""?",False, -10527508,Prednisolone related to acute myeloid leukemia,159,Primary resistance to vincristine (Vcr) and prednisolone in untreated AML was observed as well as 'acquired' resistance to several other antileukemic drugs.,"Is the triple ""Prednisolone related to acute myeloid leukemia"" supported by the sentence: ""Primary resistance to vincristine (Vcr) and prednisolone in untreated AML was observed as well as 'acquired' resistance to several other antileukemic drugs.""?",False, -10503828,Prednisolone related to seasonal allergic rhinitis,160,"REPORT of the Committee on New Drugs of the Research Council of the American Academy of Allergy, 1955-56; studies on prednisone and prednisolone in ragweed pollinosis.","Is the triple ""Prednisolone related to seasonal allergic rhinitis"" supported by the sentence: ""REPORT of the Committee on New Drugs of the Research Council of the American Academy of Allergy, 1955-56; studies on prednisone and prednisolone in ragweed pollinosis.""?",False, -10496403,Prednisolone related to Inflammation,161,Effects of prednisone and prednisolone in ocular inflammation.,"Is the triple ""Prednisolone related to Inflammation"" supported by the sentence: ""Effects of prednisone and prednisolone in ocular inflammation.""?",False, -10118116,Prednisolone related to Prednisone,162,"Prednisolone scored better than prednisone in the categories of texture, taste, and aftertaste (p < 0.05); there was no statistical difference in smell.","Is the triple ""Prednisolone related to Prednisone"" supported by the sentence: ""Prednisolone scored better than prednisone in the categories of texture, taste, and aftertaste (p < 0.05); there was no statistical difference in smell.""?",False, -9924521,Prednisolone related to colitis,163,Plasma prednisolone levels after administration of prednisolone-21-phosphate as a retention enema in colitis.,"Is the triple ""Prednisolone related to colitis"" supported by the sentence: ""Plasma prednisolone levels after administration of prednisolone-21-phosphate as a retention enema in colitis.""?",False, -9437304,Prednisolone related to systemic lupus erythematosus,164,Mizoribine as an effective combined maintenance therapy with prednisolone in child-onset systemic lupus erythematosus.,"Is the triple ""Prednisolone related to systemic lupus erythematosus"" supported by the sentence: ""Mizoribine as an effective combined maintenance therapy with prednisolone in child-onset systemic lupus erythematosus.""?",False, -9282196,Prednisolone related to IgA glomerulonephritis,165,Controlled prospective trial of prednisolone and cytotoxics in progressive IgA nephropathy.,"Is the triple ""Prednisolone related to IgA glomerulonephritis"" supported by the sentence: ""Controlled prospective trial of prednisolone and cytotoxics in progressive IgA nephropathy.""?",False, -9222009,Prednisolone related to hypereosinophilic syndrome,166,"We propose that FE(NO) is associated with eosinophilic inflammation in children with difficult asthma, following prednisolone, and may help in identifying patients in whom persistent symptoms are associated with airway eosinophilia.","Is the triple ""Prednisolone related to hypereosinophilic syndrome"" supported by the sentence: ""We propose that FE(NO) is associated with eosinophilic inflammation in children with difficult asthma, following prednisolone, and may help in identifying patients in whom persistent symptoms are associated with airway eosinophilia.""?",False, -9216084,Prednisolone related to non-Hodgkin lymphoma,167,"Liposomal daunorubicin (DaunoXome) in combination with cyclophosphamide, vincristine and prednisolone (COP-X) as salvage therapy in poor-prognosis non-Hodgkins lymphoma.","Is the triple ""Prednisolone related to non-Hodgkin lymphoma"" supported by the sentence: ""Liposomal daunorubicin (DaunoXome) in combination with cyclophosphamide, vincristine and prednisolone (COP-X) as salvage therapy in poor-prognosis non-Hodgkins lymphoma.""?",False, -9208405,Prednisolone related to Duchenne muscular dystrophy,168,Prednisolone in Duchenne muscular dystrophy.,"Is the triple ""Prednisolone related to Duchenne muscular dystrophy"" supported by the sentence: ""Prednisolone in Duchenne muscular dystrophy.""?",False, -8405261,Prednisolone related to asthma,169,Intravenous prednisolone in chronic bronchial asthma.,"Is the triple ""Prednisolone related to asthma"" supported by the sentence: ""Intravenous prednisolone in chronic bronchial asthma.""?",False, -7844202,Prednisolone related to chronic obstructive pulmonary disease,170,Reversibility with prednisolone is rarely seen in COPD.,"Is the triple ""Prednisolone related to chronic obstructive pulmonary disease"" supported by the sentence: ""Reversibility with prednisolone is rarely seen in COPD.""?",False, -7323744,Prednisolone related to pemphigus,171,"In spite of the fact that prednisolone-based treatment of pemphigus patients has proved to be effective in controlling the disease, some undesirable effects associated with this form of treatment have prompted investigation into other therapeutic approaches.","Is the triple ""Prednisolone related to pemphigus"" supported by the sentence: ""In spite of the fact that prednisolone-based treatment of pemphigus patients has proved to be effective in controlling the disease, some undesirable effects associated with this form of treatment have prompted investigation into other therapeutic approaches.""?",False, -7262473,Prednisolone related to rheumatoid arthritis,172,One reason for the good clinical effects of prednisolone in RA could be a down-regulation of adhesion and phagocytosis receptors on monocytes.,"Is the triple ""Prednisolone related to rheumatoid arthritis"" supported by the sentence: ""One reason for the good clinical effects of prednisolone in RA could be a down-regulation of adhesion and phagocytosis receptors on monocytes.""?",False, -7206314,Prednisolone related to pulmonary tuberculosis,173,OBJECTIVE: To appraise the adjunctive role of prednisolone (PN) in pulmonary tuberculosis (PTB) with toxic reactions.,"Is the triple ""Prednisolone related to pulmonary tuberculosis"" supported by the sentence: ""OBJECTIVE: To appraise the adjunctive role of prednisolone (PN) in pulmonary tuberculosis (PTB) with toxic reactions.""?",False, -8856354,Prednisolone related to Prednisone,174,"A significant reduction of survival was found with the presence of permanent visual loss vs absence (p = 0.04), in patients who required more than 10 mg/d of glucocorticoid (p < 0.001) at 6 months treatment and in patients treated with prednisone (vs prednisolone) (p < 0.01).","Is the triple ""Prednisolone related to Prednisone"" supported by the sentence: ""A significant reduction of survival was found with the presence of permanent visual loss vs absence (p = 0.04), in patients who required more than 10 mg/d of glucocorticoid (p < 0.001) at 6 months treatment and in patients treated with prednisone (vs prednisolone) (p < 0.01).""?",False, -26879702,Prednisolone has part acute lymphoblastic leukemia,175,"Fourteen patients developed hyperglycemia during induction therapy of acute lymphoblastic leukemia with L-asparaginase, prednisolone, vincristine and daunorubicin.","Is the triple ""Prednisolone has part acute lymphoblastic leukemia"" supported by the sentence: ""Fourteen patients developed hyperglycemia during induction therapy of acute lymphoblastic leukemia with L-asparaginase, prednisolone, vincristine and daunorubicin.""?",False, -26670577,Prednisolone has part plasma cell myeloma,176,A 66-year-old man was treated for IgD (lambda) multiple myeloma with 2mg/day melphalan and 20mg/day prednisolone.,"Is the triple ""Prednisolone has part plasma cell myeloma"" supported by the sentence: ""A 66-year-old man was treated for IgD (lambda) multiple myeloma with 2mg/day melphalan and 20mg/day prednisolone.""?",False, -18935086,Prednisolone coexists with Prednisone,177,"Moreover, after recent findings regarding the presence of endogenous prednisolone in the urine of more popular breeds, particular attention was given to analysis of the presence of prednisolone and prednisone, as well.","Is the triple ""Prednisolone coexists with Prednisone"" supported by the sentence: ""Moreover, after recent findings regarding the presence of endogenous prednisolone in the urine of more popular breeds, particular attention was given to analysis of the presence of prednisolone and prednisone, as well.""?",False, -9296680,Prednisolone derives from Prednisone,178,"Of 10 mg of prednisone given orally to 5 normal subjects, 69+/-5% was absorbed and converted to peripheral plasma prednisolone within 8 h.","Is the triple ""Prednisolone derives from Prednisone"" supported by the sentence: ""Of 10 mg of prednisone given orally to 5 normal subjects, 69+/-5% was absorbed and converted to peripheral plasma prednisolone within 8 h.""?",False, -26415442,Prednisolone derives from Prednisone,179,"As in humans, prednisolone was partly converted to prednisone in the rabbit.","Is the triple ""Prednisolone derives from Prednisone"" supported by the sentence: ""As in humans, prednisolone was partly converted to prednisone in the rabbit.""?",False, -14808035,Prednisolone physically interacts with Prednisone,180,"Given the close resemblance of the ring A structure of prednisolone and prednisone on the one hand, and of androstadienedione on the other, the transformation of cortisol and cortisone into prednisolone and prednisone in cattle faeces was evaluated.","Is the triple ""Prednisolone physically interacts with Prednisone"" supported by the sentence: ""Given the close resemblance of the ring A structure of prednisolone and prednisone on the one hand, and of androstadienedione on the other, the transformation of cortisol and cortisone into prednisolone and prednisone in cattle faeces was evaluated.""?",False, -9296682,Prednisolone physically interacts with Prednisone,181,The data indicate that prednisone is extensively metabolized to prednisolone before it clears the splanchnic circulation and the formation prednisone by oxidation of the 11-hydorxyl group of prednisolone appears to occur mainly in peripheral tissues.,"Is the triple ""Prednisolone physically interacts with Prednisone"" supported by the sentence: ""The data indicate that prednisone is extensively metabolized to prednisolone before it clears the splanchnic circulation and the formation prednisone by oxidation of the 11-hydorxyl group of prednisolone appears to occur mainly in peripheral tissues.""?",False, -27055840,Prednisolone causes glaucoma,182,CONCLUSION: Dexamethasone or prednisolone were the easiest to induce steroid glaucoma when the patients had long-term use of steroid eyedrops.,"Is the triple ""Prednisolone causes glaucoma"" supported by the sentence: ""CONCLUSION: Dexamethasone or prednisolone were the easiest to induce steroid glaucoma when the patients had long-term use of steroid eyedrops.""?",False, -26677891,Prednisolone causes uveitis,183,"Among 121 CK-analogs studied, CK-17, CK-101A and CK103A have been identified as promising anti-inflammatory agents as potent as prednisolone in inhibiting lens proteins-induced inflammation and twice as potent as prednisolone in inhibiting endotoxin-and IL-1-induced uveitis.","Is the triple ""Prednisolone causes uveitis"" supported by the sentence: ""Among 121 CK-analogs studied, CK-17, CK-101A and CK103A have been identified as promising anti-inflammatory agents as potent as prednisolone in inhibiting lens proteins-induced inflammation and twice as potent as prednisolone in inhibiting endotoxin-and IL-1-induced uveitis.""?",False, -25953223,Prednisolone causes kidney disorder,184,Light and electron microscopy of prednisolone-induced nephropathy in rabbits.,"Is the triple ""Prednisolone causes kidney disorder"" supported by the sentence: ""Light and electron microscopy of prednisolone-induced nephropathy in rabbits.""?",False, -21556285,Prednisolone causes allergic disease,185,The behavior results showed that exposure to prednisolone resulted in decreased autonomic activity and low sensitivity to light.,"Is the triple ""Prednisolone causes allergic disease"" supported by the sentence: ""The behavior results showed that exposure to prednisolone resulted in decreased autonomic activity and low sensitivity to light.""?",False, -21293782,Prednisolone causes adrenocortical insufficiency,186,We therefore advocate for increased clinical alertness towards prednisolone-induced adrenal insufficiency in RTx patients and thus their potential need of rescue GC supplementation during stress.,"Is the triple ""Prednisolone causes adrenocortical insufficiency"" supported by the sentence: ""We therefore advocate for increased clinical alertness towards prednisolone-induced adrenal insufficiency in RTx patients and thus their potential need of rescue GC supplementation during stress.""?",False, -20789636,Prednisolone causes ulcerative colitis,187,Zeaxanthin (50 mg/kg/day) or prednisolone (5 mg/kg/day) was orally administered for 14 days before induction of ulcerative colitis.,"Is the triple ""Prednisolone causes ulcerative colitis"" supported by the sentence: ""Zeaxanthin (50 mg/kg/day) or prednisolone (5 mg/kg/day) was orally administered for 14 days before induction of ulcerative colitis.""?",False, -17230021,Prednisolone causes Headache,188,"OBJECTIVE: We want to show that an intralesional injection of prednisolone into the proximal nail fold may produce dorsal pain, dyspnoea and headaches within the 2 min following the injection and to explain the pathophysiology of his condition.","Is the triple ""Prednisolone causes Headache"" supported by the sentence: ""OBJECTIVE: We want to show that an intralesional injection of prednisolone into the proximal nail fold may produce dorsal pain, dyspnoea and headaches within the 2 min following the injection and to explain the pathophysiology of his condition.""?",False, -16304261,Prednisolone causes nephrotic syndrome,189,[A case of nephrotic syndrome with abnormally high level of protein C induced by prednisolone].,"Is the triple ""Prednisolone causes nephrotic syndrome"" supported by the sentence: ""[A case of nephrotic syndrome with abnormally high level of protein C induced by prednisolone].""?",False, -15365269,Prednisolone causes infertility disorder,190,It is concluded that six or more cycles of COPP chemotherapy for advanced Hodgkin's disease in men leads to permanent sterility.,"Is the triple ""Prednisolone causes infertility disorder"" supported by the sentence: ""It is concluded that six or more cycles of COPP chemotherapy for advanced Hodgkin's disease in men leads to permanent sterility.""?",False, -14373522,Prednisolone causes exfoliative dermatitis,191,The erythroderma improved generally as a result of systemic prednisolone treatment.,"Is the triple ""Prednisolone causes exfoliative dermatitis"" supported by the sentence: ""The erythroderma improved generally as a result of systemic prednisolone treatment.""?",False, -10735861,Prednisolone causes contact dermatitis,192,CONTACT DERMATITIS DUE TO TOPICAL HYDROCORTISONE AND PREDNISOLONE.,"Is the triple ""Prednisolone causes contact dermatitis"" supported by the sentence: ""CONTACT DERMATITIS DUE TO TOPICAL HYDROCORTISONE AND PREDNISOLONE.""?",False, -10545904,Prednisolone causes pulmonary tuberculosis,193,[Pulmonary tuberculosis due to prednisolone].,"Is the triple ""Prednisolone causes pulmonary tuberculosis"" supported by the sentence: ""[Pulmonary tuberculosis due to prednisolone].""?",False, -10519611,Prednisolone causes colitis,194,"Rats were treated with a leukotriene synthesis inhibitor (PF-5901), a leukotriene B4 receptor antagonist (SC-41930), an IL-1 receptor antagonist or a corticosteroid (prednisolone) prior to induction of colitis.","Is the triple ""Prednisolone causes colitis"" supported by the sentence: ""Rats were treated with a leukotriene synthesis inhibitor (PF-5901), a leukotriene B4 receptor antagonist (SC-41930), an IL-1 receptor antagonist or a corticosteroid (prednisolone) prior to induction of colitis.""?",False, -9464043,Prednisolone causes cataract,195,"PURPOSE: To investigate the relationship between vitamin E deficiency and prednisolone-induced cataract formation, long-term examination of lens changes was performed in rats under the condition of vitamin E deficiency or supplementation and administration of prednisolone.","Is the triple ""Prednisolone causes cataract"" supported by the sentence: ""PURPOSE: To investigate the relationship between vitamin E deficiency and prednisolone-induced cataract formation, long-term examination of lens changes was performed in rats under the condition of vitamin E deficiency or supplementation and administration of prednisolone.""?",False, -8757881,Prednisolone causes systemic lupus erythematosus,196,"In inactive SLE induced by prednisolone therapy, the invariant Valpha24JalphaQ TCR could be detected in DN Valpha24+ T cells from all the patients and dominated in most of the patients.","Is the triple ""Prednisolone causes systemic lupus erythematosus"" supported by the sentence: ""In inactive SLE induced by prednisolone therapy, the invariant Valpha24JalphaQ TCR could be detected in DN Valpha24+ T cells from all the patients and dominated in most of the patients.""?",False, -27658451,Prednisolone affects uveitis,197,"Interleukin-1 (IL-1) blockers, CK 127 and CK 129, were found to inhibit IL-1-induced posterior uveitis very effectively at 3-10 mg/kg i.p. and were more potent than prednisolone which required at least 20 mg/kg i.p. to achieve the same level of anti-uveitis action.","Is the triple ""Prednisolone affects uveitis"" supported by the sentence: ""Interleukin-1 (IL-1) blockers, CK 127 and CK 129, were found to inhibit IL-1-induced posterior uveitis very effectively at 3-10 mg/kg i.p. and were more potent than prednisolone which required at least 20 mg/kg i.p. to achieve the same level of anti-uveitis action.""?",False, -27410586,Prednisolone affects castration-resistant prostate carcinoma,198,[A case of hormone-refractory prostate cancer responsive to low-dose prednisolone therapy].,"Is the triple ""Prednisolone affects castration-resistant prostate carcinoma"" supported by the sentence: ""[A case of hormone-refractory prostate cancer responsive to low-dose prednisolone therapy].""?",False, -27323391,Prednisolone affects focal segmental glomerulosclerosis,199,6 cases of FSGS had poor response to any therapy; 7 cases were responsive to either triple therapy or cyclosporine A plus prednisolone.,"Is the triple ""Prednisolone affects focal segmental glomerulosclerosis"" supported by the sentence: ""6 cases of FSGS had poor response to any therapy; 7 cases were responsive to either triple therapy or cyclosporine A plus prednisolone.""?",False, -27042309,Prednisolone affects pulmonary eosinophilia,200,"From 1983, exacerbation of PIE was recorded three times, on which occasions prednisolone and antibiotics were quite effective.","Is the triple ""Prednisolone affects pulmonary eosinophilia"" supported by the sentence: ""From 1983, exacerbation of PIE was recorded three times, on which occasions prednisolone and antibiotics were quite effective.""?",False, -25790510,Prednisolone affects allergic disease,201,"A comparative study of the effects of ACTH, hydrocortisone and prednisolone in the hypersensitive reactions produced with the protein components of Hymenolepis nana in albino mice.","Is the triple ""Prednisolone affects allergic disease"" supported by the sentence: ""A comparative study of the effects of ACTH, hydrocortisone and prednisolone in the hypersensitive reactions produced with the protein components of Hymenolepis nana in albino mice.""?",False, -25165576,Prednisolone affects glomerulonephritis,202,"Immunosuppressant therapy, such as prednisolone or azathioprine, is considered for exacerbations of highly active glomerulonephritis.","Is the triple ""Prednisolone affects glomerulonephritis"" supported by the sentence: ""Immunosuppressant therapy, such as prednisolone or azathioprine, is considered for exacerbations of highly active glomerulonephritis.""?",False, -24270725,Prednisolone affects dermatomyositis,203,"We describe a 57-year-old Caucasian male with anti-MDA5 positive dermatomyositis, that had a 4-month history of progressive dyspnoea requiring oxygen-therapy, scarcely responsive to prednisolone.","Is the triple ""Prednisolone affects dermatomyositis"" supported by the sentence: ""We describe a 57-year-old Caucasian male with anti-MDA5 positive dermatomyositis, that had a 4-month history of progressive dyspnoea requiring oxygen-therapy, scarcely responsive to prednisolone.""?",False, -22922261,Prednisolone affects allergic bronchopulmonary aspergillosis,204,"After 14 months of treatment one of the patients developed severe, acute exacerbation of the ABPA and was treated with high-dose prednisolone and local steroid.","Is the triple ""Prednisolone affects allergic bronchopulmonary aspergillosis"" supported by the sentence: ""After 14 months of treatment one of the patients developed severe, acute exacerbation of the ABPA and was treated with high-dose prednisolone and local steroid.""?",False, -19824794,Prednisolone affects colitis,205,"The effect of pretreatment with topical prostaglandin E2, prednisolone and sulphasalazine in experimental colitis has been examined in the rat colon.","Is the triple ""Prednisolone affects colitis"" supported by the sentence: ""The effect of pretreatment with topical prostaglandin E2, prednisolone and sulphasalazine in experimental colitis has been examined in the rat colon.""?",False, -19409335,Prednisolone affects sarcoidosis,206,"Here, we report a case of prednisolone-dependent gastric sarcoidosis that improved after additional azathioprine, and also review the literature concerning the treatment, especially for prednisolone-dependent cases.","Is the triple ""Prednisolone affects sarcoidosis"" supported by the sentence: ""Here, we report a case of prednisolone-dependent gastric sarcoidosis that improved after additional azathioprine, and also review the literature concerning the treatment, especially for prednisolone-dependent cases.""?",False, -18736907,Prednisolone affects asthma,207,"METHODS: In 126 adults (33 healthy control subjects, 31 patients with mild asthma, 32 patients with severe asthma, and 30 patients with prednisolone-dependent asthma) parameters of inflammation (peripheral blood eosinophils and neutrophils) and markers of hemostasis (endogenous thrombin potential [ETP], thrombin-antithrombin complex, plasmin-alpha2-antiplasmin complex, plasminogen activator inhibitor type 1 [PAI-1], D-dimer, and von Willebrand factor [vWF]) were measured in plasma.","Is the triple ""Prednisolone affects asthma"" supported by the sentence: ""METHODS: In 126 adults (33 healthy control subjects, 31 patients with mild asthma, 32 patients with severe asthma, and 30 patients with prednisolone-dependent asthma) parameters of inflammation (peripheral blood eosinophils and neutrophils) and markers of hemostasis (endogenous thrombin potential [ETP], thrombin-antithrombin complex, plasmin-alpha2-antiplasmin complex, plasminogen activator inhibitor type 1 [PAI-1], D-dimer, and von Willebrand factor [vWF]) were measured in plasma.""?",False, -17668631,Prednisolone affects Prednisone,208,Previous studies from our laboratory revealed that coadministration of EP significantly increased the plasma concentration of prednisolone while decreased the level of cotreated prednisone in rats.,"Is the triple ""Prednisolone affects Prednisone"" supported by the sentence: ""Previous studies from our laboratory revealed that coadministration of EP significantly increased the plasma concentration of prednisolone while decreased the level of cotreated prednisone in rats.""?",False, -15888410,Prednisolone affects rheumatoid arthritis,209,Metabolic effects of high-dose prednisolone treatment in early rheumatoid arthritis: balance between diabetogenic effects and inflammation reduction.,"Is the triple ""Prednisolone affects rheumatoid arthritis"" supported by the sentence: ""Metabolic effects of high-dose prednisolone treatment in early rheumatoid arthritis: balance between diabetogenic effects and inflammation reduction.""?",False, -13564625,Prednisolone affects asthma,210,"Effects of prednisolone, salbutamol and theophylline on bronchial hyperreactivity and leucocyte chemokinesis in guinea pigs.","Is the triple ""Prednisolone affects asthma"" supported by the sentence: ""Effects of prednisolone, salbutamol and theophylline on bronchial hyperreactivity and leucocyte chemokinesis in guinea pigs.""?",False, -13234063,Prednisolone affects pericarditis,211,"This is the first case to support the beneficial effect of prednisolone in pericarditis with pSS, and illustrates its safety during pregnancy.","Is the triple ""Prednisolone affects pericarditis"" supported by the sentence: ""This is the first case to support the beneficial effect of prednisolone in pericarditis with pSS, and illustrates its safety during pregnancy.""?",False, -13029310,Prednisolone affects chronic obstructive pulmonary disease,212,"When combined with environmental control, prednisolone and dexamethasone treatments had similar effects on heaves score, blood gases and endoscopic scores.","Is the triple ""Prednisolone affects chronic obstructive pulmonary disease"" supported by the sentence: ""When combined with environmental control, prednisolone and dexamethasone treatments had similar effects on heaves score, blood gases and endoscopic scores.""?",False, -12949384,Prednisolone affects hypereosinophilic syndrome,213,"Of the 20 patients, 14 initially received prednisolone treatment, which resulted in rapid improvement and normalization of eosinophilia within 8 weeks; however, 2 patients with splenomegaly showed poor control of eosinophilia in response to corticosteroid treatment.","Is the triple ""Prednisolone affects hypereosinophilic syndrome"" supported by the sentence: ""Of the 20 patients, 14 initially received prednisolone treatment, which resulted in rapid improvement and normalization of eosinophilia within 8 weeks; however, 2 patients with splenomegaly showed poor control of eosinophilia in response to corticosteroid treatment.""?",False, -12057849,Prednisolone affects Crohn disease,214,Complement activation capacity in plasma before and during high-dose prednisolone treatment and tapering in exacerbations of Crohn's disease and ulcerative colitis.,"Is the triple ""Prednisolone affects Crohn disease"" supported by the sentence: ""Complement activation capacity in plasma before and during high-dose prednisolone treatment and tapering in exacerbations of Crohn's disease and ulcerative colitis.""?",False, -11166436,Prednisolone affects Headache,215,Prednisolone-responsive headache in patients with solitary cysticercus granuloma and seizures.,"Is the triple ""Prednisolone affects Headache"" supported by the sentence: ""Prednisolone-responsive headache in patients with solitary cysticercus granuloma and seizures.""?",False, -11074135,Prednisolone affects lymphoma,216,"The patient was treated with chemotherapy by cyclophosphamide, hydroxydoxorubicin, vincristine and prednisolone (CHOP), however, it was ineffective, and the patient died of hemorrhage from the lymphoma involvement of the intestine 5 months after the onset of disease.","Is the triple ""Prednisolone affects lymphoma"" supported by the sentence: ""The patient was treated with chemotherapy by cyclophosphamide, hydroxydoxorubicin, vincristine and prednisolone (CHOP), however, it was ineffective, and the patient died of hemorrhage from the lymphoma involvement of the intestine 5 months after the onset of disease.""?",False, -10651502,Prednisolone affects kidney disorder,217,Effect of prednisolone in the experimentally induced nephropathy in male albino rats.,"Is the triple ""Prednisolone affects kidney disorder"" supported by the sentence: ""Effect of prednisolone in the experimentally induced nephropathy in male albino rats.""?",False, -10649036,Prednisolone affects chorioretinitis,218,[On the effect of oral use of prednisolone on central chorioretinitis].,"Is the triple ""Prednisolone affects chorioretinitis"" supported by the sentence: ""[On the effect of oral use of prednisolone on central chorioretinitis].""?",False, -10555139,Prednisolone affects peptic ulcer disease,219,Peptic ulceration associated with prednisolone therapy.,"Is the triple ""Prednisolone affects peptic ulcer disease"" supported by the sentence: ""Peptic ulceration associated with prednisolone therapy.""?",False, -10183156,Prednisolone affects ulcerative colitis,220,"Glucocorticoids (e.g. prednisolone) are cornerstones in the treatment of acute exacerbations of ulcerative colitis (UC), and influence of the leucocyte/endothelial interaction appears to be part of their mode of action.","Is the triple ""Prednisolone affects ulcerative colitis"" supported by the sentence: ""Glucocorticoids (e.g. prednisolone) are cornerstones in the treatment of acute exacerbations of ulcerative colitis (UC), and influence of the leucocyte/endothelial interaction appears to be part of their mode of action.""?",False, -9735520,Prednisolone affects Inflammation,221,"Effects of honey, prednisolone, and disulfiram on inflammation, nitric oxide, and free radical formation.","Is the triple ""Prednisolone affects Inflammation"" supported by the sentence: ""Effects of honey, prednisolone, and disulfiram on inflammation, nitric oxide, and free radical formation.""?",False, -9361682,Prednisolone affects osteoarthritis,222,OBJECTIVE: To assess the treatment effect of sodium hyaluronate (HA) on experimental temporomandibular joint (TMJ) osteoarthritis of rabbits in comparison with prednisolone (PS).,"Is the triple ""Prednisolone affects osteoarthritis"" supported by the sentence: ""OBJECTIVE: To assess the treatment effect of sodium hyaluronate (HA) on experimental temporomandibular joint (TMJ) osteoarthritis of rabbits in comparison with prednisolone (PS).""?",False, -8533593,Prednisolone affects neoplasm,223,"ETO+PSL combination treatment, however, failed to show significant enhancement of anti-tumor effects.","Is the triple ""Prednisolone affects neoplasm"" supported by the sentence: ""ETO+PSL combination treatment, however, failed to show significant enhancement of anti-tumor effects.""?",False, -7800426,Prednisolone affects acute lymphoblastic leukemia,224,"My- and My+ ALL did not significantly differ in sensitivity to prednisolone, dexamethasone, L-asparaginase and cytarabine.","Is the triple ""Prednisolone affects acute lymphoblastic leukemia"" supported by the sentence: ""My- and My+ ALL did not significantly differ in sensitivity to prednisolone, dexamethasone, L-asparaginase and cytarabine.""?",False, -7395227,Prednisolone affects systemic lupus erythematosus,225,"The dose of prednisolone was increased considering he was exacerbated of SLE, however, the convulsion as CNS lupus occurred to him.","Is the triple ""Prednisolone affects systemic lupus erythematosus"" supported by the sentence: ""The dose of prednisolone was increased considering he was exacerbated of SLE, however, the convulsion as CNS lupus occurred to him.""?",False, -21722189,Prednisolone affects Prednisone,226,"In a pilot study using one rabbit, prednisone and prednisolone clearance values increased with increase in either prednisone or prednisolone infusion rates.","Is the triple ""Prednisolone affects Prednisone"" supported by the sentence: ""In a pilot study using one rabbit, prednisone and prednisolone clearance values increased with increase in either prednisone or prednisolone infusion rates.""?",False, -9655099,Prednisolone has input Prednisone,227,"Budesonide is equal to less effective than prednisolone or prednisone therapy in the treatment of active Crohn's disease, but is associated with fewer glucocorticoids adverse reactions.","Is the triple ""Prednisolone has input Prednisone"" supported by the sentence: ""Budesonide is equal to less effective than prednisolone or prednisone therapy in the treatment of active Crohn's disease, but is associated with fewer glucocorticoids adverse reactions.""?",False, -27206106,Prednisolone disrupts uveitis,228,Diclofenac and prednisolone inhibit endotoxin-induced uveitis in rabbits.,"Is the triple ""Prednisolone disrupts uveitis"" supported by the sentence: ""Diclofenac and prednisolone inhibit endotoxin-induced uveitis in rabbits.""?",False, -26515767,Prednisolone disrupts neoplasm,229,"Although prednisolone and GH reverse hypoglycemia by different mechanisms, with only prednisolone suppressing tumor IGF-II secretion, both increase the formation of ternary IGF-IGFBP-3 complexes.","Is the triple ""Prednisolone disrupts neoplasm"" supported by the sentence: ""Although prednisolone and GH reverse hypoglycemia by different mechanisms, with only prednisolone suppressing tumor IGF-II secretion, both increase the formation of ternary IGF-IGFBP-3 complexes.""?",False, -26379811,Prednisolone disrupts contact dermatitis,230,"The aqueous extract of Saiboku-to also showed an inhibition of the contact dermatitis, and it significantly potentiated the inhibition of contact dermatitis by prednisolone.","Is the triple ""Prednisolone disrupts contact dermatitis"" supported by the sentence: ""The aqueous extract of Saiboku-to also showed an inhibition of the contact dermatitis, and it significantly potentiated the inhibition of contact dermatitis by prednisolone.""?",False, -25763558,Prednisolone disrupts pneumonia,231,Only hydrocortisone and prednisolone suppressed LPS pneumonia.,"Is the triple ""Prednisolone disrupts pneumonia"" supported by the sentence: ""Only hydrocortisone and prednisolone suppressed LPS pneumonia.""?",False, -25233555,Prednisolone disrupts allergic disease,232,"Prednisolone significantly inhibited the measurable sensitivity of IDT, while oclacitinib did not.","Is the triple ""Prednisolone disrupts allergic disease"" supported by the sentence: ""Prednisolone significantly inhibited the measurable sensitivity of IDT, while oclacitinib did not.""?",False, -14331279,Prednisolone disrupts hypereosinophilic syndrome,233,"A comparison with the bronchodilator potency of the above drugs indicated that in guinea pigs salbutamol appears relatively selective as a bronchodilator, prednisolone is selective as an inhibitor of eosinophilia whilst theophylline displays a balance of both activities.","Is the triple ""Prednisolone disrupts hypereosinophilic syndrome"" supported by the sentence: ""A comparison with the bronchodilator potency of the above drugs indicated that in guinea pigs salbutamol appears relatively selective as a bronchodilator, prednisolone is selective as an inhibitor of eosinophilia whilst theophylline displays a balance of both activities.""?",False, -10594561,Prednisolone disrupts asthma,234,Reduction of maintenance doses of prednisolone in bronchial asthma by the concurrent use of hydroxyzine.,"Is the triple ""Prednisolone disrupts asthma"" supported by the sentence: ""Reduction of maintenance doses of prednisolone in bronchial asthma by the concurrent use of hydroxyzine.""?",False, -8854473,Prednisolone disrupts Inflammation,235,"In contrast, cyclosporin A (CyA), FK-506 and prednisolone significantly inhibited antigen-induced airway inflammation and BHR in sensitized BN rats.","Is the triple ""Prednisolone disrupts Inflammation"" supported by the sentence: ""In contrast, cyclosporin A (CyA), FK-506 and prednisolone significantly inhibited antigen-induced airway inflammation and BHR in sensitized BN rats.""?",False, -27646185,Prednisolone prevents allergic disease,236,[Use of corticosteroids betamethasone and prednisolone in the prevention of allergic reactions in patients undergoing heart surgery with artificial blood circulation].,"Is the triple ""Prednisolone prevents allergic disease"" supported by the sentence: ""[Use of corticosteroids betamethasone and prednisolone in the prevention of allergic reactions in patients undergoing heart surgery with artificial blood circulation].""?",False, -26227245,Prednisolone prevents synovitis,237,The intra-articular injection of prednisolone was shown to considerably reduce incidence of synovitis.,"Is the triple ""Prednisolone prevents synovitis"" supported by the sentence: ""The intra-articular injection of prednisolone was shown to considerably reduce incidence of synovitis.""?",False, -19453072,Prednisolone prevents hypereosinophilic syndrome,238,"Prednisolone (100 mg/die initially, decreasing doses thereafter) led to significant reduction of infiltrates and eosinophilia.","Is the triple ""Prednisolone prevents hypereosinophilic syndrome"" supported by the sentence: ""Prednisolone (100 mg/die initially, decreasing doses thereafter) led to significant reduction of infiltrates and eosinophilia.""?",False, -16706850,Prednisolone prevents neoplasm,239,The tumour was significantly reduced by prednisolone.,"Is the triple ""Prednisolone prevents neoplasm"" supported by the sentence: ""The tumour was significantly reduced by prednisolone.""?",False, -15809068,Prednisolone prevents colitis,240,"Prednisolone prevented the development of colitis, but had no effect on already-developed colitis.","Is the triple ""Prednisolone prevents colitis"" supported by the sentence: ""Prednisolone prevented the development of colitis, but had no effect on already-developed colitis.""?",False, -11858005,Prednisolone prevents asthma,241,Alveolar NO concentration was increased in patients with refractory asthma (7.1 ppb) compared with mild-to-moderate asthma (3.4 ppb) and normal controls (3.4 ppb) and reduced by treatment with prednisolone.,"Is the triple ""Prednisolone prevents asthma"" supported by the sentence: ""Alveolar NO concentration was increased in patients with refractory asthma (7.1 ppb) compared with mild-to-moderate asthma (3.4 ppb) and normal controls (3.4 ppb) and reduced by treatment with prednisolone.""?",False, -10983909,Prednisolone prevents leprosy,242,"Prednisolone treatment of sensory impairment of the ulnar and posterior tibial nerves detectable with the monofilament test, but not with the ballpen test, did not improve the long-term outcome in terms of recovery of touch sensibility, not did it reduce the risk of leprosy reactions or nerve function impairment beyond the initial 4-month treatment phase.","Is the triple ""Prednisolone prevents leprosy"" supported by the sentence: ""Prednisolone treatment of sensory impairment of the ulnar and posterior tibial nerves detectable with the monofilament test, but not with the ballpen test, did not improve the long-term outcome in terms of recovery of touch sensibility, not did it reduce the risk of leprosy reactions or nerve function impairment beyond the initial 4-month treatment phase.""?",False, -10240036,Prednisolone prevents Inflammation,243,CONCLUSIONS: Predocol is an oral preparation of a poorly absorbed salt of prednisolone that is effective in reducing inflammation over short treatment periods in patients with active ulcerative colitis.,"Is the triple ""Prednisolone prevents Inflammation"" supported by the sentence: ""CONCLUSIONS: Predocol is an oral preparation of a poorly absorbed salt of prednisolone that is effective in reducing inflammation over short treatment periods in patients with active ulcerative colitis.""?",False, -18452194,Prednisolone exacerbates ulcerative colitis,244,"Six weeks prior to his symptoms, prednisolone (PSL) and SASP had been started because of UC aggravation.","Is the triple ""Prednisolone exacerbates ulcerative colitis"" supported by the sentence: ""Six weeks prior to his symptoms, prednisolone (PSL) and SASP had been started because of UC aggravation.""?",False, -25753407,Prednisolone predisposes neoplasm,245,"When comparing organ specific, age-adjusted expected versus observed incidences after natural death of animals an increased tumor risk was found in organ systems of all treatment modalities but prednisolone.","Is the triple ""Prednisolone predisposes neoplasm"" supported by the sentence: ""When comparing organ specific, age-adjusted expected versus observed incidences after natural death of animals an increased tumor risk was found in organ systems of all treatment modalities but prednisolone.""?",False, -16546227,Prednisolone predisposes pneumonia,246,"R-CHOP chemotherapy composed of rituximab, cyclophosphamide, adriamycin, vincristine, and prednisolone which might increase the risk of Pneumocystis pneumonia in patients with non-Hodgkin lymphoma.","Is the triple ""Prednisolone predisposes pneumonia"" supported by the sentence: ""R-CHOP chemotherapy composed of rituximab, cyclophosphamide, adriamycin, vincristine, and prednisolone which might increase the risk of Pneumocystis pneumonia in patients with non-Hodgkin lymphoma.""?",False, -27027571,Hydrocortisone related to HIV infectious disease,247,"Cortisol deficiency is common in late stage HIV disease, but symptoms of fatigue and postural hypotension, as well as biochemical findings, are poor predictors of cortisol deficiency.","Is the triple ""Hydrocortisone related to HIV infectious disease"" supported by the sentence: ""Cortisol deficiency is common in late stage HIV disease, but symptoms of fatigue and postural hypotension, as well as biochemical findings, are poor predictors of cortisol deficiency.""?",False, -25927636,Hydrocortisone related to cardiac arrest,248,[Plasma cortisol and 17-ketosteroids in urine in relation to cardiac arrest].,"Is the triple ""Hydrocortisone related to cardiac arrest"" supported by the sentence: ""[Plasma cortisol and 17-ketosteroids in urine in relation to cardiac arrest].""?",False, -25797574,Hydrocortisone related to lymphoma,249,"Independence of theta and TL surface antigens and killing by thymidine, cortisol, phytohemagglutinin, and cyclic AMP in a murine lymphoma.","Is the triple ""Hydrocortisone related to lymphoma"" supported by the sentence: ""Independence of theta and TL surface antigens and killing by thymidine, cortisol, phytohemagglutinin, and cyclic AMP in a murine lymphoma.""?",False, -25131277,Hydrocortisone related to Crohn disease,250,"Furthermore, this treatment process demonstrated the superior anti-inflammatory effect of prednisolone over that of hydrocortisone and supported the assumption of inflammation related to CD.","Is the triple ""Hydrocortisone related to Crohn disease"" supported by the sentence: ""Furthermore, this treatment process demonstrated the superior anti-inflammatory effect of prednisolone over that of hydrocortisone and supported the assumption of inflammation related to CD.""?",False, -19793698,Hydrocortisone related to alcohol abuse,251,"Ordinary least squared (OLS) regression was used to evaluate whether race moderated the associations between alcohol abuse and four biomarkers-urinary cortisol and serum dehydroepiandrosterone sulfate (DHEA-S), epinephrine and norepinephrine-and two composite summary scores, each consisting of two components that characterize the hypothalamic pituitary adrenal (HPA)-axis and sympathetic nervous systems (SNS), respectively.","Is the triple ""Hydrocortisone related to alcohol abuse"" supported by the sentence: ""Ordinary least squared (OLS) regression was used to evaluate whether race moderated the associations between alcohol abuse and four biomarkers-urinary cortisol and serum dehydroepiandrosterone sulfate (DHEA-S), epinephrine and norepinephrine-and two composite summary scores, each consisting of two components that characterize the hypothalamic pituitary adrenal (HPA)-axis and sympathetic nervous systems (SNS), respectively.""?",False, -19531872,Hydrocortisone related to atrial fibrillation,252,"CONCLUSION: In patients with septic shock, low-dose hydrocortisone was associated with a lower risk of developing AF during the acute phase.","Is the triple ""Hydrocortisone related to atrial fibrillation"" supported by the sentence: ""CONCLUSION: In patients with septic shock, low-dose hydrocortisone was associated with a lower risk of developing AF during the acute phase.""?",False, -18705900,Hydrocortisone related to phobic disorder,253,"The incidence of psychological symptoms as somatization, obsessive-compulsive symptoms, depression, anxiety, phobia, and nonspecific symptoms is statistically increased in pregnant women with elevated morning cortisol, but in women with elevated afternoon cortisol also occurring aggressiveness and paranoia.","Is the triple ""Hydrocortisone related to phobic disorder"" supported by the sentence: ""The incidence of psychological symptoms as somatization, obsessive-compulsive symptoms, depression, anxiety, phobia, and nonspecific symptoms is statistically increased in pregnant women with elevated morning cortisol, but in women with elevated afternoon cortisol also occurring aggressiveness and paranoia.""?",False, -15155784,Hydrocortisone related to psoriasis,254,How stress gets under the skin: cortisol and stress reactivity in psoriasis.,"Is the triple ""Hydrocortisone related to psoriasis"" supported by the sentence: ""How stress gets under the skin: cortisol and stress reactivity in psoriasis.""?",False, -14891361,"Hydrocortisone related to dermatitis, atopic",255,Absorption of hydrocortisone from the skin reservoir in atopic dermatitis.,"Is the triple ""Hydrocortisone related to dermatitis, atopic"" supported by the sentence: ""Absorption of hydrocortisone from the skin reservoir in atopic dermatitis.""?",False, -14483328,Hydrocortisone related to bronchopulmonary dysplasia,256,OBJECTIVE: To assess dexamethasone (DEX) and hydrocortisone (HC) use in premature infants over time and the association of steroid use with the incidence of bronchopulmonary dysplasia (BPD) at 36 weeks' postmenstrual age.,"Is the triple ""Hydrocortisone related to bronchopulmonary dysplasia"" supported by the sentence: ""OBJECTIVE: To assess dexamethasone (DEX) and hydrocortisone (HC) use in premature infants over time and the association of steroid use with the incidence of bronchopulmonary dysplasia (BPD) at 36 weeks' postmenstrual age.""?",False, -14450267,Hydrocortisone related to adrenal cortex neoplasm,257,Increased ratio of mRNA expression of the genes CYP17 and CYP11B1 indicates autonomous cortisol production in adrenocortical tumors.,"Is the triple ""Hydrocortisone related to adrenal cortex neoplasm"" supported by the sentence: ""Increased ratio of mRNA expression of the genes CYP17 and CYP11B1 indicates autonomous cortisol production in adrenocortical tumors.""?",False, -14387016,Hydrocortisone related to cirrhosis of liver,258,"It is concluded that bile acids are potent endogenous inhibitors of 11 beta-HSD and, therefore, could participate in abnormalities of cortisol metabolism observed in liver cirrhosis and extrahepatic biliary obstruction and, possibly, after ingestion of bile acids.","Is the triple ""Hydrocortisone related to cirrhosis of liver"" supported by the sentence: ""It is concluded that bile acids are potent endogenous inhibitors of 11 beta-HSD and, therefore, could participate in abnormalities of cortisol metabolism observed in liver cirrhosis and extrahepatic biliary obstruction and, possibly, after ingestion of bile acids.""?",False, -14360687,Hydrocortisone related to dermatitis,259,"The plasma cortisol concentration was significantly higher in both DD groups before treatment than in the control group, and it decreased significantly after hoof trimming in the trimmed group.","Is the triple ""Hydrocortisone related to dermatitis"" supported by the sentence: ""The plasma cortisol concentration was significantly higher in both DD groups before treatment than in the control group, and it decreased significantly after hoof trimming in the trimmed group.""?",False, -13844584,Hydrocortisone related to acute myeloid leukemia,260,Hydrocortisone in culture protects the blast cells in acute myeloblastic leukemia from the lethal effects of cytosine arabinoside.,"Is the triple ""Hydrocortisone related to acute myeloid leukemia"" supported by the sentence: ""Hydrocortisone in culture protects the blast cells in acute myeloblastic leukemia from the lethal effects of cytosine arabinoside.""?",False, -13213365,Hydrocortisone related to chronic primary adrenal insufficiency,261,Continuous subcutaneous hydrocortisone infusion in Addison's disease.,"Is the triple ""Hydrocortisone related to chronic primary adrenal insufficiency"" supported by the sentence: ""Continuous subcutaneous hydrocortisone infusion in Addison's disease.""?",False, -12756660,Hydrocortisone related to borderline personality disorder,262,The current findings underline the relevance of cortisol and DHEA assessments and the need for further scrutiny of their interplay to foster our understanding of the biological basis of stress regulation in BPD.,"Is the triple ""Hydrocortisone related to borderline personality disorder"" supported by the sentence: ""The current findings underline the relevance of cortisol and DHEA assessments and the need for further scrutiny of their interplay to foster our understanding of the biological basis of stress regulation in BPD.""?",False, -12576998,Hydrocortisone related to Hypoxemia,263,"This hypoxia-specific increase in surface beta-adrenoreceptors was significantly enhanced in the cortisol-treated erythrocytes, showing that cortisol had a significant impact on erythrocyte beta-adrenoreceptor dynamics in addition to the direct influence of hypoxia.","Is the triple ""Hydrocortisone related to Hypoxemia"" supported by the sentence: ""This hypoxia-specific increase in surface beta-adrenoreceptors was significantly enhanced in the cortisol-treated erythrocytes, showing that cortisol had a significant impact on erythrocyte beta-adrenoreceptor dynamics in addition to the direct influence of hypoxia.""?",False, -11888652,Hydrocortisone related to congenital adrenal hyperplasia,264,"Congenital adrenal hyperplasia (CAH) due to deficiency of 21-hydroxylase is a disorder of the adrenal cortex characterised by cortisol deficiency, with or without aldosterone deficiency, and androgen excess.","Is the triple ""Hydrocortisone related to congenital adrenal hyperplasia"" supported by the sentence: ""Congenital adrenal hyperplasia (CAH) due to deficiency of 21-hydroxylase is a disorder of the adrenal cortex characterised by cortisol deficiency, with or without aldosterone deficiency, and androgen excess.""?",False, -11866289,Hydrocortisone related to nicotine dependence,265,"Changes of smoking behavior and serum adrenocorticotropic hormone, cortisol, prolactin, and endogenous opioids levels in nicotine dependence after naltrexone treatment.","Is the triple ""Hydrocortisone related to nicotine dependence"" supported by the sentence: ""Changes of smoking behavior and serum adrenocorticotropic hormone, cortisol, prolactin, and endogenous opioids levels in nicotine dependence after naltrexone treatment.""?",False, -11530989,Hydrocortisone related to pneumonia,266,We hypothesize that hydrocortisone infusion in severe community-acquired pneumonia attenuates systemic inflammation and leads to earlier resolution of pneumonia and a reduction in sepsis-related complications.,"Is the triple ""Hydrocortisone related to pneumonia"" supported by the sentence: ""We hypothesize that hydrocortisone infusion in severe community-acquired pneumonia attenuates systemic inflammation and leads to earlier resolution of pneumonia and a reduction in sepsis-related complications.""?",False, -11442939,Hydrocortisone related to prostate cancer,267,A prospective study was performed to investigate the combination of the aromatase inhibitor aminoglutethimide and hydrocortisone in androgen-independent prostate cancer with changes in prostate-specific antigen (PSA) level as main determinant for response.,"Is the triple ""Hydrocortisone related to prostate cancer"" supported by the sentence: ""A prospective study was performed to investigate the combination of the aromatase inhibitor aminoglutethimide and hydrocortisone in androgen-independent prostate cancer with changes in prostate-specific antigen (PSA) level as main determinant for response.""?",False, -11089023,Hydrocortisone related to pancreatitis,268,"To investigate the time courses of the effects of the exogenous glucocorticoid agonists dexamethasone (DEX) and hydrocortisone (HYD) and a glucocorticoid antagonist (RU-38486), and to characterize the local and systemic responses in experimental AP.","Is the triple ""Hydrocortisone related to pancreatitis"" supported by the sentence: ""To investigate the time courses of the effects of the exogenous glucocorticoid agonists dexamethasone (DEX) and hydrocortisone (HYD) and a glucocorticoid antagonist (RU-38486), and to characterize the local and systemic responses in experimental AP.""?",False, -10649902,Hydrocortisone related to myocardial infarction,269,[The adrenal cortex and hydrocortisone metabolism in experimental myocardial infarct].,"Is the triple ""Hydrocortisone related to myocardial infarction"" supported by the sentence: ""[The adrenal cortex and hydrocortisone metabolism in experimental myocardial infarct].""?",False, -10522181,Hydrocortisone related to osteoarthritis,270,[Intraarticular hydrocortisone (cortril) in arthritis and osteoarthritis].,"Is the triple ""Hydrocortisone related to osteoarthritis"" supported by the sentence: ""[Intraarticular hydrocortisone (cortril) in arthritis and osteoarthritis].""?",False, -10521296,Hydrocortisone related to eye disorder,271,[Use of cortisone and hydrocortisone in eye diseases].,"Is the triple ""Hydrocortisone related to eye disorder"" supported by the sentence: ""[Use of cortisone and hydrocortisone in eye diseases].""?",False, -10518203,Hydrocortisone related to otitis externa,272,[Topical use of hydrocortisone in otitis externa].,"Is the triple ""Hydrocortisone related to otitis externa"" supported by the sentence: ""[Topical use of hydrocortisone in otitis externa].""?",False, -10484611,Hydrocortisone related to ulcerative colitis,273,The use of hydrocortisone in ulcerative colitis: preliminary observations.,"Is the triple ""Hydrocortisone related to ulcerative colitis"" supported by the sentence: ""The use of hydrocortisone in ulcerative colitis: preliminary observations.""?",False, -9718673,Hydrocortisone related to atopic eczema,274,It can therefore be concluded that ointments containing either only E. coli BCS or a combination of BCS and hydrocortisone provide significant relief in perianal eczema as well as in early stages of hemorrhoidal disease.,"Is the triple ""Hydrocortisone related to atopic eczema"" supported by the sentence: ""It can therefore be concluded that ointments containing either only E. coli BCS or a combination of BCS and hydrocortisone provide significant relief in perianal eczema as well as in early stages of hemorrhoidal disease.""?",False, -9492934,Hydrocortisone related to opiate dependence,275,The effect on cortisol supports the above conclusion and is consistent with HPA axis perturbation in opioid dependence as reported in other studies and extends these observations to stable methadone-maintained patients.,"Is the triple ""Hydrocortisone related to opiate dependence"" supported by the sentence: ""The effect on cortisol supports the above conclusion and is consistent with HPA axis perturbation in opioid dependence as reported in other studies and extends these observations to stable methadone-maintained patients.""?",False, -9238280,Hydrocortisone related to Sepsis,276,Several randomized controlled trials have evaluated the efficacy of a replacement therapy with hydrocortisone in severe sepsis.,"Is the triple ""Hydrocortisone related to Sepsis"" supported by the sentence: ""Several randomized controlled trials have evaluated the efficacy of a replacement therapy with hydrocortisone in severe sepsis.""?",False, -9235597,Hydrocortisone related to type 1 diabetes mellitus,277,[Diurnal variations in blood glucose and plasma cortisol in juvenile diabetes mellitus without ketoacidosis].,"Is the triple ""Hydrocortisone related to type 1 diabetes mellitus"" supported by the sentence: ""[Diurnal variations in blood glucose and plasma cortisol in juvenile diabetes mellitus without ketoacidosis].""?",False, -8977987,Hydrocortisone related to injury,278,"OBJECTIVES: Elderly women with proximal femur fracture show abnormal persistence of increased cortisol concentrations, which could contribute to the high morbidity associated with this injury.","Is the triple ""Hydrocortisone related to injury"" supported by the sentence: ""OBJECTIVES: Elderly women with proximal femur fracture show abnormal persistence of increased cortisol concentrations, which could contribute to the high morbidity associated with this injury.""?",False, -8778414,Hydrocortisone related to Inflammation,279,"From the compendium presented above, the following statements become evident: 1) Inappropriately low secretion of cortisol in relation to inflammation is a typical feature of the inflammatory disease in patients with RA.","Is the triple ""Hydrocortisone related to Inflammation"" supported by the sentence: ""From the compendium presented above, the following statements become evident: 1) Inappropriately low secretion of cortisol in relation to inflammation is a typical feature of the inflammatory disease in patients with RA.""?",False, -8763179,Hydrocortisone related to toxic shock syndrome,280,Hydrocortisone infusion in septic shock differentially regulated the cytokine responses.,"Is the triple ""Hydrocortisone related to toxic shock syndrome"" supported by the sentence: ""Hydrocortisone infusion in septic shock differentially regulated the cytokine responses.""?",False, -8625521,Hydrocortisone related to dissociative amnesia,281,"BACKGROUND: There is substantial evidence of dysregulation of cortisol secretion, hippocampal abnormalities, and memory deficits in schizophrenia and other psychotic disorders.","Is the triple ""Hydrocortisone related to dissociative amnesia"" supported by the sentence: ""BACKGROUND: There is substantial evidence of dysregulation of cortisol secretion, hippocampal abnormalities, and memory deficits in schizophrenia and other psychotic disorders.""?",False, -8615164,Hydrocortisone related to asthma,282,(2) One of the mechanisms of therapeutic effect of cortisol in asthma might be its inhibitory effect on CA uptake.,"Is the triple ""Hydrocortisone related to asthma"" supported by the sentence: ""(2) One of the mechanisms of therapeutic effect of cortisol in asthma might be its inhibitory effect on CA uptake.""?",False, -8570630,Hydrocortisone related to fibromyalgia,283,"OBJECTIVE: To compare cortisol levels, diurnal cycles of cortisol, and reactivity of cortisol to psychological stress in fibromyalgia (FM) and rheumatoid arthritis (RA) patients in their natural environment, and to examine the effect on results of accounting for differences among the groups in psychological stress and other lifestyle and psychosocial variables.","Is the triple ""Hydrocortisone related to fibromyalgia"" supported by the sentence: ""OBJECTIVE: To compare cortisol levels, diurnal cycles of cortisol, and reactivity of cortisol to psychological stress in fibromyalgia (FM) and rheumatoid arthritis (RA) patients in their natural environment, and to examine the effect on results of accounting for differences among the groups in psychological stress and other lifestyle and psychosocial variables.""?",False, -8017438,Hydrocortisone related to Insulin resistance,284,"OBJECTIVES: Recent data suggest that higher plasma cortisol may be associated with hypertension and insulin resistance in otherwise healthy men, as it is in Cushing's syndrome.","Is the triple ""Hydrocortisone related to Insulin resistance"" supported by the sentence: ""OBJECTIVES: Recent data suggest that higher plasma cortisol may be associated with hypertension and insulin resistance in otherwise healthy men, as it is in Cushing's syndrome.""?",False, -7919367,Hydrocortisone related to adrenocortical insufficiency,285,"These findings demonstrate 2 types of adrenal insufficiency with different clinical pictures: Type 1 is characterized by cortisol deficiency with hypoglycaemia, low corticoid levels and a low cortisol secretion rate; Type 2 shows aldosterone deficiency with prominent salt loss.","Is the triple ""Hydrocortisone related to adrenocortical insufficiency"" supported by the sentence: ""These findings demonstrate 2 types of adrenal insufficiency with different clinical pictures: Type 1 is characterized by cortisol deficiency with hypoglycaemia, low corticoid levels and a low cortisol secretion rate; Type 2 shows aldosterone deficiency with prominent salt loss.""?",False, -7573954,Hydrocortisone related to neoplasm,286,"November, a period of reproductive quiescence in the southern hemisphere, with new antler growth and rapid weight gain, is associated with higher mean plasma cortisol concentrations and a greater responsiveness to exogenous ACTH.","Is the triple ""Hydrocortisone related to neoplasm"" supported by the sentence: ""November, a period of reproductive quiescence in the southern hemisphere, with new antler growth and rapid weight gain, is associated with higher mean plasma cortisol concentrations and a greater responsiveness to exogenous ACTH.""?",False, -7182905,Hydrocortisone related to obesity disorder,287,Cortisol metabolism in human obesity: impaired cortisone-->cortisol conversion in subjects with central adiposity.,"Is the triple ""Hydrocortisone related to obesity disorder"" supported by the sentence: ""Cortisol metabolism in human obesity: impaired cortisone-->cortisol conversion in subjects with central adiposity.""?",False, -24445107,Hydrocortisone related to Inflammation,288,The hypothalamic-pituitary-adrenal (HPA) axis is one of the key physiological systems that counterbalances this systemic inflammation through changes in adrenocorticotrophic hormone (ACTH) and cortisol.,"Is the triple ""Hydrocortisone related to Inflammation"" supported by the sentence: ""The hypothalamic-pituitary-adrenal (HPA) axis is one of the key physiological systems that counterbalances this systemic inflammation through changes in adrenocorticotrophic hormone (ACTH) and cortisol.""?",False, -24030854,Hydrocortisone related to Hypoxemia,289,"The 5 dpf hypoxic exposure also elicited transient increases in whole body cortisol and in crf, uts1, and hsd20b2 expression, key regulators of the endocrine stress response.","Is the triple ""Hydrocortisone related to Hypoxemia"" supported by the sentence: ""The 5 dpf hypoxic exposure also elicited transient increases in whole body cortisol and in crf, uts1, and hsd20b2 expression, key regulators of the endocrine stress response.""?",False, -12533519,Hydrocortisone related to Insulin resistance,290,"At multiple regression analyses, HOMA-IR on admission in the IR group significantly correlated with thyroid-stimulating hormone, glucagon, and cortisol.","Is the triple ""Hydrocortisone related to Insulin resistance"" supported by the sentence: ""At multiple regression analyses, HOMA-IR on admission in the IR group significantly correlated with thyroid-stimulating hormone, glucagon, and cortisol.""?",False, -27747116,Hydrocortisone causes toxic shock syndrome,291,"The suppression of the anti-inflammatory effects of cortisol as a result of states of excessive stress leads to hypercatabolic diseases such as AIDS, sepsis and toxic shock syndrome and protein calorie malnutrition (NAIDS).","Is the triple ""Hydrocortisone causes toxic shock syndrome"" supported by the sentence: ""The suppression of the anti-inflammatory effects of cortisol as a result of states of excessive stress leads to hypercatabolic diseases such as AIDS, sepsis and toxic shock syndrome and protein calorie malnutrition (NAIDS).""?",False, -27747115,Hydrocortisone causes Sepsis,292,"The suppression of the anti-inflammatory effects of cortisol as a result of states of excessive stress leads to hypercatabolic diseases such as AIDS, sepsis and toxic shock syndrome and protein calorie malnutrition (NAIDS).","Is the triple ""Hydrocortisone causes Sepsis"" supported by the sentence: ""The suppression of the anti-inflammatory effects of cortisol as a result of states of excessive stress leads to hypercatabolic diseases such as AIDS, sepsis and toxic shock syndrome and protein calorie malnutrition (NAIDS).""?",False, -27073884,Hydrocortisone causes atopic eczema,293,"We report the case of a 41-year-old nonatopic women with a previous history of eczematous reaction due to hydrocortisone who suffered worsening of her perennial rhinitis in association with perinasal dermatitis from the use of budesonide in nasal spray form, and stomatitis and pharyngitis due to budesonide in a bronchial inhaler.","Is the triple ""Hydrocortisone causes atopic eczema"" supported by the sentence: ""We report the case of a 41-year-old nonatopic women with a previous history of eczematous reaction due to hydrocortisone who suffered worsening of her perennial rhinitis in association with perinasal dermatitis from the use of budesonide in nasal spray form, and stomatitis and pharyngitis due to budesonide in a bronchial inhaler.""?",False, -25383174,Hydrocortisone causes fibromyalgia,294,"In this perspective paper, we focus on the neuro-endocrine interactions that occur between progesterone, allopregnanolone, and cortisol during pregnancy, and propose that they align with our previously proposed model of FM pathogenesis based on GABAergic ""weakening"" in a thalamocortical neural loop system.","Is the triple ""Hydrocortisone causes fibromyalgia"" supported by the sentence: ""In this perspective paper, we focus on the neuro-endocrine interactions that occur between progesterone, allopregnanolone, and cortisol during pregnancy, and propose that they align with our previously proposed model of FM pathogenesis based on GABAergic ""weakening"" in a thalamocortical neural loop system.""?",False, -25205462,Hydrocortisone causes hypotensive disorder,295,The present study reported a case of hydrocortisone-induced blood pressure reduction in a patient with anterior pituitary hypofunction due to allergic reaction.,"Is the triple ""Hydrocortisone causes hypotensive disorder"" supported by the sentence: ""The present study reported a case of hydrocortisone-induced blood pressure reduction in a patient with anterior pituitary hypofunction due to allergic reaction.""?",False, -20591759,Hydrocortisone causes Hypoxemia,296,Fetal adrenocorticotropic hormone and cortisol increased to peak values within 2.8 hours of induced hypoxia but by 7.2 hours had begun to fall to values that were not significantly different from those at 1.4 hours.,"Is the triple ""Hydrocortisone causes Hypoxemia"" supported by the sentence: ""Fetal adrenocorticotropic hormone and cortisol increased to peak values within 2.8 hours of induced hypoxia but by 7.2 hours had begun to fall to values that were not significantly different from those at 1.4 hours.""?",False, -18446972,Hydrocortisone causes congenital adrenal hyperplasia,297,Congenital adrenal hyperplasia (CAH) is a chronic condition and individuals are exposed to elevated androgen levels in utero as a result of the endogenous cortisol deficiency.,"Is the triple ""Hydrocortisone causes congenital adrenal hyperplasia"" supported by the sentence: ""Congenital adrenal hyperplasia (CAH) is a chronic condition and individuals are exposed to elevated androgen levels in utero as a result of the endogenous cortisol deficiency.""?",False, -18240145,Hydrocortisone causes injury,298,The results of our study confirm that thymol has strong ameliorative effect against hydrocortisone-induced oxidative stress injury in hepatic tissues.,"Is the triple ""Hydrocortisone causes injury"" supported by the sentence: ""The results of our study confirm that thymol has strong ameliorative effect against hydrocortisone-induced oxidative stress injury in hepatic tissues.""?",False, -17359303,Hydrocortisone causes influenza,299,The effects of 8-bromo-cyclic AMP and cyclic AMP agonists (cholera toxin plus hydrocortisone and prostaglandin E2 plus 3-isobutyl-1-methylxanthine) on the cytotoxic activity of T cells generated during murine influenza virus infection have been examined.,"Is the triple ""Hydrocortisone causes influenza"" supported by the sentence: ""The effects of 8-bromo-cyclic AMP and cyclic AMP agonists (cholera toxin plus hydrocortisone and prostaglandin E2 plus 3-isobutyl-1-methylxanthine) on the cytotoxic activity of T cells generated during murine influenza virus infection have been examined.""?",False, -13585273,"Hydrocortisone causes dermatitis, atopic",300,Open oral provocation with 100 or 250 mg hydrocortisone in patients with hydrocortisone contact hypersensitivity elicited cutaneous reactions at sites of previous allergic dermatitis caused by hydrocortisone in two patients and at sites of earlier allergic patch test reactions caused by hydrocortisone in the other two patients.,"Is the triple ""Hydrocortisone causes dermatitis, atopic"" supported by the sentence: ""Open oral provocation with 100 or 250 mg hydrocortisone in patients with hydrocortisone contact hypersensitivity elicited cutaneous reactions at sites of previous allergic dermatitis caused by hydrocortisone in two patients and at sites of earlier allergic patch test reactions caused by hydrocortisone in the other two patients.""?",False, -12645476,Hydrocortisone causes obesity disorder,301,"Although initial studies in transgenic mice and humans are encouraging, more data are required to conclusively prove the hypothesis that the adipose-tissue-specific overexpression of HSD1 and the resultant increase in tissue-specific cortisol concentrations result in human obesity, insulin resistance, high blood pressure, and metabolic syndrome.","Is the triple ""Hydrocortisone causes obesity disorder"" supported by the sentence: ""Although initial studies in transgenic mice and humans are encouraging, more data are required to conclusively prove the hypothesis that the adipose-tissue-specific overexpression of HSD1 and the resultant increase in tissue-specific cortisol concentrations result in human obesity, insulin resistance, high blood pressure, and metabolic syndrome.""?",False, -10068843,Hydrocortisone causes Inflammation,302,"CONCLUSION: Although hydrocortisone has anti-inflammatory properties, it seems to provoke inflammation in the round window membrane after topical instillation.","Is the triple ""Hydrocortisone causes Inflammation"" supported by the sentence: ""CONCLUSION: Although hydrocortisone has anti-inflammatory properties, it seems to provoke inflammation in the round window membrane after topical instillation.""?",False, -9850315,Hydrocortisone causes dissociative amnesia,303,"Type 2 glucocorticoid receptors (GRs), which are occupied by cortisol in humans in times of stress, are thought to be responsible for the glucocorticoid-induced memory impairment.","Is the triple ""Hydrocortisone causes dissociative amnesia"" supported by the sentence: ""Type 2 glucocorticoid receptors (GRs), which are occupied by cortisol in humans in times of stress, are thought to be responsible for the glucocorticoid-induced memory impairment.""?",False, -9318796,Hydrocortisone causes adrenocortical insufficiency,304,"Firstly, the GH-mediated increase in cortisol metabolism (mediated via reduced E to F conversion) may precipitate adrenal insufficiency in hypopituitary patients with partial adrenocorticotropic hormone deficiency commencing GH therapy.","Is the triple ""Hydrocortisone causes adrenocortical insufficiency"" supported by the sentence: ""Firstly, the GH-mediated increase in cortisol metabolism (mediated via reduced E to F conversion) may precipitate adrenal insufficiency in hypopituitary patients with partial adrenocorticotropic hormone deficiency commencing GH therapy.""?",False, -9145908,Hydrocortisone causes otitis externa,305,"From this study it is inferred that the group III steroid betamethasone dipropionate alone heals experimentally induced external otitis more rapidly than hydrocortisone with oxytetracycline, with or without polymyxin B.","Is the triple ""Hydrocortisone causes otitis externa"" supported by the sentence: ""From this study it is inferred that the group III steroid betamethasone dipropionate alone heals experimentally induced external otitis more rapidly than hydrocortisone with oxytetracycline, with or without polymyxin B.""?",False, -8699464,Hydrocortisone causes adrenal cortex neoplasm,306,"In conclusion, the reciprocal expression of CYP17 and the transcriptional repressors COUP-TF and DAX-1 indicates that these orphan receptors have a pathophysiologic role in the excessive hormone production in cortisol- and deoxycorticosterone-producing adrenocortical tumors.","Is the triple ""Hydrocortisone causes adrenal cortex neoplasm"" supported by the sentence: ""In conclusion, the reciprocal expression of CYP17 and the transcriptional repressors COUP-TF and DAX-1 indicates that these orphan receptors have a pathophysiologic role in the excessive hormone production in cortisol- and deoxycorticosterone-producing adrenocortical tumors.""?",False, -8657746,Hydrocortisone causes neoplasm,307,"The administration of hydrocortisone before tumor inoculation resulted in increased tumor take, reduced mean survival time of mice, and concentration of tumor metastasis in a specific organ (i.e., lung metastasis for Ehrlich hypotetraploid clone 1 tumor, and liver metastasis for Ehrlich hypotetraploid stock and Ehrlich hyperdiploid stock tumors).","Is the triple ""Hydrocortisone causes neoplasm"" supported by the sentence: ""The administration of hydrocortisone before tumor inoculation resulted in increased tumor take, reduced mean survival time of mice, and concentration of tumor metastasis in a specific organ (i.e., lung metastasis for Ehrlich hypotetraploid clone 1 tumor, and liver metastasis for Ehrlich hypotetraploid stock and Ehrlich hyperdiploid stock tumors).""?",False, -7929803,Hydrocortisone causes Insulin resistance,308,"Cortisol counteracts the insulin activation of glycogen synthase in muscle, the insulin inhibition of hepatic glucose production and the insulin inhibition of lipolysis in adipose tissue, leading to the well-established systemic insulin resistance caused by excess cortisol.","Is the triple ""Hydrocortisone causes Insulin resistance"" supported by the sentence: ""Cortisol counteracts the insulin activation of glycogen synthase in muscle, the insulin inhibition of hepatic glucose production and the insulin inhibition of lipolysis in adipose tissue, leading to the well-established systemic insulin resistance caused by excess cortisol.""?",False, -7432490,Hydrocortisone causes pancreatitis,309,"The amount of N-acetyl D-glucosamine in the zymogen granule membrane was not altered by caerulein acute pancreatitis induced under continuous hydrocortisone treatment, but it was decreased by the administration of L-364,718 over 7 days after pancreatitis induction.","Is the triple ""Hydrocortisone causes pancreatitis"" supported by the sentence: ""The amount of N-acetyl D-glucosamine in the zymogen granule membrane was not altered by caerulein acute pancreatitis induced under continuous hydrocortisone treatment, but it was decreased by the administration of L-364,718 over 7 days after pancreatitis induction.""?",False, -26997315,Hydrocortisone affects congenital adrenal hyperplasia,310,False elevation of plasma cortisol in congenital adrenal hyperplasia.,"Is the triple ""Hydrocortisone affects congenital adrenal hyperplasia"" supported by the sentence: ""False elevation of plasma cortisol in congenital adrenal hyperplasia.""?",False, -26940919,Hydrocortisone affects cardiac arrest,311,Further studies evaluating the mechanism of action and long term effects of hydrocortisone in cardiac arrest need to be conducted.,"Is the triple ""Hydrocortisone affects cardiac arrest"" supported by the sentence: ""Further studies evaluating the mechanism of action and long term effects of hydrocortisone in cardiac arrest need to be conducted.""?",False, -26840479,Hydrocortisone affects myocardial infarction,312,"In acute MI, there were elevated plasma levels of cortisol depending on the MI severity with a small repeated peak of its increase on day 14 and its subsequent decrease, except deaths.","Is the triple ""Hydrocortisone affects myocardial infarction"" supported by the sentence: ""In acute MI, there were elevated plasma levels of cortisol depending on the MI severity with a small repeated peak of its increase on day 14 and its subsequent decrease, except deaths.""?",False, -24701128,Hydrocortisone affects Sepsis,313,"Aldosterone levels, like cortisol, have been shown to be increased in sepsis and hemorrhagic shock.","Is the triple ""Hydrocortisone affects Sepsis"" supported by the sentence: ""Aldosterone levels, like cortisol, have been shown to be increased in sepsis and hemorrhagic shock.""?",False, -21274202,Hydrocortisone affects osteoarthritis,314,"In this review, we summarize the effects of circadian melatonin, TSH, and cortisol on OA, focusing on how different levels of these hormones affect OA pathogenesis and recovery with respect to the circadian clock.","Is the triple ""Hydrocortisone affects osteoarthritis"" supported by the sentence: ""In this review, we summarize the effects of circadian melatonin, TSH, and cortisol on OA, focusing on how different levels of these hormones affect OA pathogenesis and recovery with respect to the circadian clock.""?",False, -20701310,Hydrocortisone affects psoriasis,315,"There may be a subset of patients unable to elicit an appropriate immunosuppressive response to stress through upregulation of cortisol, with resultant exacerbation of their psoriasis.","Is the triple ""Hydrocortisone affects psoriasis"" supported by the sentence: ""There may be a subset of patients unable to elicit an appropriate immunosuppressive response to stress through upregulation of cortisol, with resultant exacerbation of their psoriasis.""?",False, -20336537,Hydrocortisone affects dermatitis,316,"In addition to local effect, topical hydrocortisone therapy of childhood dermatitis is accompanied by a systemic effect that may be pronounced in the acute phase of disease.","Is the triple ""Hydrocortisone affects dermatitis"" supported by the sentence: ""In addition to local effect, topical hydrocortisone therapy of childhood dermatitis is accompanied by a systemic effect that may be pronounced in the acute phase of disease.""?",False, -20137862,Hydrocortisone affects fibromyalgia,317,"They answered the Fibromyalgia Impact Questionnaire (FIQ), Perceived Stress Questionnaire (PSQ) and McGill Pain Questionnaire (MPQ-Br), and collected saliva to evaluate CC before and after the end of each month.","Is the triple ""Hydrocortisone affects fibromyalgia"" supported by the sentence: ""They answered the Fibromyalgia Impact Questionnaire (FIQ), Perceived Stress Questionnaire (PSQ) and McGill Pain Questionnaire (MPQ-Br), and collected saliva to evaluate CC before and after the end of each month.""?",False, -19555227,Hydrocortisone affects pneumonia,318,"BACKGROUND: The hypothalamic-pituitary-adrenal stress axis plays a crucial role in community-acquired pneumonia (CAP), with high cortisol being associated with disease severity and corticosteroid treatment resulting in earlier time to recovery.","Is the triple ""Hydrocortisone affects pneumonia"" supported by the sentence: ""BACKGROUND: The hypothalamic-pituitary-adrenal stress axis plays a crucial role in community-acquired pneumonia (CAP), with high cortisol being associated with disease severity and corticosteroid treatment resulting in earlier time to recovery.""?",False, -19531871,Hydrocortisone affects atrial fibrillation,319,"The incidence of AF was compared among patients who received hydrocortisone, and the effect of low-dose hydrocortisone on AF was estimated using the inverse probability treatment weighting method based on propensity scores.","Is the triple ""Hydrocortisone affects atrial fibrillation"" supported by the sentence: ""The incidence of AF was compared among patients who received hydrocortisone, and the effect of low-dose hydrocortisone on AF was estimated using the inverse probability treatment weighting method based on propensity scores.""?",False, -18495054,Hydrocortisone affects lymphoma,320,"INTRODUCTION: Intrathecal administration of methotrexate, cytarabine, and hydrocortisone is commonly used to treat and prevent central nervous system involvement in leukemias and lymphomas.","Is the triple ""Hydrocortisone affects lymphoma"" supported by the sentence: ""INTRODUCTION: Intrathecal administration of methotrexate, cytarabine, and hydrocortisone is commonly used to treat and prevent central nervous system involvement in leukemias and lymphomas.""?",False, -18495053,Hydrocortisone affects leukemia,321,"INTRODUCTION: Intrathecal administration of methotrexate, cytarabine, and hydrocortisone is commonly used to treat and prevent central nervous system involvement in leukemias and lymphomas.","Is the triple ""Hydrocortisone affects leukemia"" supported by the sentence: ""INTRODUCTION: Intrathecal administration of methotrexate, cytarabine, and hydrocortisone is commonly used to treat and prevent central nervous system involvement in leukemias and lymphomas.""?",False, -18310128,Hydrocortisone affects toxic shock syndrome,322,"CONCLUSIONS: Early PN did not affect plasma concentrations of ACTH and (free) cortisol, but increased the incidence of septic shock, which statistically explained why more patients on early PN received corticosteroids.","Is the triple ""Hydrocortisone affects toxic shock syndrome"" supported by the sentence: ""CONCLUSIONS: Early PN did not affect plasma concentrations of ACTH and (free) cortisol, but increased the incidence of septic shock, which statistically explained why more patients on early PN received corticosteroids.""?",False, -17910566,Hydrocortisone affects atopic eczema,323,"Sixteen reacted to tixocortol pivalate and also to other corticosteroids, particularly to hydrocortisone, which could explain exacerbations of eczema in these cases.","Is the triple ""Hydrocortisone affects atopic eczema"" supported by the sentence: ""Sixteen reacted to tixocortol pivalate and also to other corticosteroids, particularly to hydrocortisone, which could explain exacerbations of eczema in these cases.""?",False, -15925719,Hydrocortisone affects Inflammation,324,"Finally, transient pre-treatment of healthy humans with cortisol induces a bi-phasic response during a later, delayed systemic inflammatory response: an intermediate cortisol concentration augments inflammation while a high cortisol concentration is neither pro- nor anti-inflammatory.","Is the triple ""Hydrocortisone affects Inflammation"" supported by the sentence: ""Finally, transient pre-treatment of healthy humans with cortisol induces a bi-phasic response during a later, delayed systemic inflammatory response: an intermediate cortisol concentration augments inflammation while a high cortisol concentration is neither pro- nor anti-inflammatory.""?",False, -14970164,Hydrocortisone affects Insulin resistance,325,"Adrenaline induces the early posthypoglycaemic insulin resistance, whereas cortisol and growth hormone are important for the insulin resistance that is observed later following hypoglycaemia.","Is the triple ""Hydrocortisone affects Insulin resistance"" supported by the sentence: ""Adrenaline induces the early posthypoglycaemic insulin resistance, whereas cortisol and growth hormone are important for the insulin resistance that is observed later following hypoglycaemia.""?",False, -14804311,Hydrocortisone affects injury,326,"RESULTS: Within 24 hours following TBI, the concentrations of total cortisol, ACTH and gastrin increased proportionally to the severity of injury, especially significant in the experimental group (P less than 0.05).","Is the triple ""Hydrocortisone affects injury"" supported by the sentence: ""RESULTS: Within 24 hours following TBI, the concentrations of total cortisol, ACTH and gastrin increased proportionally to the severity of injury, especially significant in the experimental group (P less than 0.05).""?",False, -14533429,Hydrocortisone affects hypotensive disorder,327,NEW OR UNIQUE INFORMATION PROVIDED: This case is the first published report of hydrocortisone-responsive hypotension and transient CIRCI associated with naturally occurring septic shock in a dog.,"Is the triple ""Hydrocortisone affects hypotensive disorder"" supported by the sentence: ""NEW OR UNIQUE INFORMATION PROVIDED: This case is the first published report of hydrocortisone-responsive hypotension and transient CIRCI associated with naturally occurring septic shock in a dog.""?",False, -13999195,Hydrocortisone affects congenital adrenal hyperplasia,328,Several types of the congenital adrenal hyperplasias are associated with decreased cortisol production and excessive adrenal sex steroid secretion.,"Is the triple ""Hydrocortisone affects congenital adrenal hyperplasia"" supported by the sentence: ""Several types of the congenital adrenal hyperplasias are associated with decreased cortisol production and excessive adrenal sex steroid secretion.""?",False, -13347553,Hydrocortisone affects asthma,329,[Use of cryo-apheresis in the treatment of patients with cortisol-dependent bronchial asthma].,"Is the triple ""Hydrocortisone affects asthma"" supported by the sentence: ""[Use of cryo-apheresis in the treatment of patients with cortisol-dependent bronchial asthma].""?",False, -13180935,Hydrocortisone affects hypotensive disorder,330,Hypotension after recruitment was reduced by HC (0 vs. 30%).,"Is the triple ""Hydrocortisone affects hypotensive disorder"" supported by the sentence: ""Hypotension after recruitment was reduced by HC (0 vs. 30%).""?",False, -11695335,Hydrocortisone affects Hypoxemia,331,Fetal plasma cortisol concentrations were increased ( P < 0.05) during all levels of hypoxia.,"Is the triple ""Hydrocortisone affects Hypoxemia"" supported by the sentence: ""Fetal plasma cortisol concentrations were increased ( P < 0.05) during all levels of hypoxia.""?",False, -11304252,Hydrocortisone affects obesity disorder,332,"INTRA-CELL CORTISOL: Attention is also focused on the potential implication of cortisol in the genesis of metabolic syndrome, because cortisol is a potent antagonist of the effect of insulin and its presence in excess enhances visceral obesity and insulin resistance.","Is the triple ""Hydrocortisone affects obesity disorder"" supported by the sentence: ""INTRA-CELL CORTISOL: Attention is also focused on the potential implication of cortisol in the genesis of metabolic syndrome, because cortisol is a potent antagonist of the effect of insulin and its presence in excess enhances visceral obesity and insulin resistance.""?",False, -10523644,Hydrocortisone affects injury,333,The effect of hydrocortisone on standardized skin-surface trauma.,"Is the triple ""Hydrocortisone affects injury"" supported by the sentence: ""The effect of hydrocortisone on standardized skin-surface trauma.""?",False, -10431364,Hydrocortisone affects Inflammation,334,The action of hydrocortisone in synovial inflammation.,"Is the triple ""Hydrocortisone affects Inflammation"" supported by the sentence: ""The action of hydrocortisone in synovial inflammation.""?",False, -10074536,Hydrocortisone affects HIV infectious disease,335,"The effects of stressful life events, coping, and cortisol on HIV infection.","Is the triple ""Hydrocortisone affects HIV infectious disease"" supported by the sentence: ""The effects of stressful life events, coping, and cortisol on HIV infection.""?",False, -9872405,Hydrocortisone affects toxic shock syndrome,336,"Immunologic and hemodynamic effects of ""low-dose"" hydrocortisone in septic shock: a double-blind, randomized, placebo-controlled, crossover study.","Is the triple ""Hydrocortisone affects toxic shock syndrome"" supported by the sentence: ""Immunologic and hemodynamic effects of ""low-dose"" hydrocortisone in septic shock: a double-blind, randomized, placebo-controlled, crossover study.""?",False, -9610203,Hydrocortisone affects neoplasm,337,"To prolong the anti-tumor effect some mice were also given cyclophosphamide, hydrocortisone, or a second injection of virus.","Is the triple ""Hydrocortisone affects neoplasm"" supported by the sentence: ""To prolong the anti-tumor effect some mice were also given cyclophosphamide, hydrocortisone, or a second injection of virus.""?",False, -9120606,Hydrocortisone affects asthma,338,"In conclusion, HRT in postmenopausal asthmatic women has a favorable influence on the course of asthma, reduces daily use of glucocorticosteroids and frequency of asthma exacerbations and normalizes serum concentrations of estradiol, cortisol and DHEAS, which were decreased before HRT.","Is the triple ""Hydrocortisone affects asthma"" supported by the sentence: ""In conclusion, HRT in postmenopausal asthmatic women has a favorable influence on the course of asthma, reduces daily use of glucocorticosteroids and frequency of asthma exacerbations and normalizes serum concentrations of estradiol, cortisol and DHEAS, which were decreased before HRT.""?",False, -8017440,Hydrocortisone affects obesity disorder,339,"However, after adjusting for the effect of obesity by multiple regression, higher plasma cortisol was independently associated with higher diastolic blood pressure in men (r = 0.21, P = 0.04) but not in women, and higher fasting serum triglyceride levels in women (r = 0.28, P < 0. 001) but not in men.","Is the triple ""Hydrocortisone affects obesity disorder"" supported by the sentence: ""However, after adjusting for the effect of obesity by multiple regression, higher plasma cortisol was independently associated with higher diastolic blood pressure in men (r = 0.21, P = 0.04) but not in women, and higher fasting serum triglyceride levels in women (r = 0.28, P < 0. 001) but not in men.""?",False, -7974249,Hydrocortisone affects Insulin resistance,340,"ii) Reduction of cortisone to cortisol in the liver may increase insulin resistance in type 2 diabetes mellitus, and inhibition of the enzyme may lead to a decrease in gluconeogenesis.","Is the triple ""Hydrocortisone affects Insulin resistance"" supported by the sentence: ""ii) Reduction of cortisone to cortisol in the liver may increase insulin resistance in type 2 diabetes mellitus, and inhibition of the enzyme may lead to a decrease in gluconeogenesis.""?",False, -7366981,Hydrocortisone affects Hypoxemia,341,"Pretreatment of rats with hydrocortisone or protamin-Zn-insulin within 4 days altered in subsequent acute hypoxia (3 hrs, ""height"" 10 000 m) the isoenzyme spectrum of LDH in lungs, liver tissue and kidney cortex.","Is the triple ""Hydrocortisone affects Hypoxemia"" supported by the sentence: ""Pretreatment of rats with hydrocortisone or protamin-Zn-insulin within 4 days altered in subsequent acute hypoxia (3 hrs, ""height"" 10 000 m) the isoenzyme spectrum of LDH in lungs, liver tissue and kidney cortex.""?",False, -7266667,Hydrocortisone affects dissociative amnesia,342,Previously we related persistent cortisol increases to memory impairments in elderly humans studied over five years.,"Is the triple ""Hydrocortisone affects dissociative amnesia"" supported by the sentence: ""Previously we related persistent cortisol increases to memory impairments in elderly humans studied over five years.""?",False, -27426083,Hydrocortisone produces HIV infectious disease,343,It was suggested that the progressive shift from type 1 to type 2 cytokine production characteristic of HIV infection could be at least partially provoked by the increase in the production of cortisol and the reduction of DHEA.,"Is the triple ""Hydrocortisone produces HIV infectious disease"" supported by the sentence: ""It was suggested that the progressive shift from type 1 to type 2 cytokine production characteristic of HIV infection could be at least partially provoked by the increase in the production of cortisol and the reduction of DHEA.""?",False, -24427531,Hydrocortisone produces cirrhosis of liver,344,CONCLUSIONS: This study suggests that 24 h urinary free cortisol could be considered as a potential index of adrenal cortisol production in patients with liver cirrhosis and it potentially detects patients with a high mortality risk.,"Is the triple ""Hydrocortisone produces cirrhosis of liver"" supported by the sentence: ""CONCLUSIONS: This study suggests that 24 h urinary free cortisol could be considered as a potential index of adrenal cortisol production in patients with liver cirrhosis and it potentially detects patients with a high mortality risk.""?",False, -23738730,Hydrocortisone produces congenital adrenal hyperplasia,345,Congenital adrenal hyperplasia (CAH) is an autosomal recessive disorder that leads to the partial or complete deficiency of cortisol and aldosterone production from the adrenal glands.,"Is the triple ""Hydrocortisone produces congenital adrenal hyperplasia"" supported by the sentence: ""Congenital adrenal hyperplasia (CAH) is an autosomal recessive disorder that leads to the partial or complete deficiency of cortisol and aldosterone production from the adrenal glands.""?",False, -20514012,"Hydrocortisone produces dermatitis, atopic",346,[Reaction of autogenous cortisol production in patients with extensive psoriasis vulgaris or atopic dermatitis following external administration of a 0.25% prednicarbate salve (W/O emulsion)].,"Is the triple ""Hydrocortisone produces dermatitis, atopic"" supported by the sentence: ""[Reaction of autogenous cortisol production in patients with extensive psoriasis vulgaris or atopic dermatitis following external administration of a 0.25% prednicarbate salve (W/O emulsion)].""?",False, -18924640,Hydrocortisone produces Inflammation,347,"OBJECTIVE: Corticosteroid-binding globulin (CBG), the cortisol transport protein, is cleaved from high-affinity (haCBG) to low-affinity (laCBG) CBG at sites of inflammation releasing bioavailable, anti-inflammatory cortisol.","Is the triple ""Hydrocortisone produces Inflammation"" supported by the sentence: ""OBJECTIVE: Corticosteroid-binding globulin (CBG), the cortisol transport protein, is cleaved from high-affinity (haCBG) to low-affinity (laCBG) CBG at sites of inflammation releasing bioavailable, anti-inflammatory cortisol.""?",False, -16473285,Hydrocortisone produces type 1 diabetes mellitus,348,The propensity to develop type 1 diabetes or type 2 diabetes/metabolic syndrome depends on the propensity to release of cortisol which correlates with race.,"Is the triple ""Hydrocortisone produces type 1 diabetes mellitus"" supported by the sentence: ""The propensity to develop type 1 diabetes or type 2 diabetes/metabolic syndrome depends on the propensity to release of cortisol which correlates with race.""?",False, -15760263,Hydrocortisone produces toxic shock syndrome,349,"CIRCI is characterized by an inadequate production of cortisol in relation to an increased demand during periods of severe stress, particularly in critical illnesses such as sepsis or septic shock.","Is the triple ""Hydrocortisone produces toxic shock syndrome"" supported by the sentence: ""CIRCI is characterized by an inadequate production of cortisol in relation to an increased demand during periods of severe stress, particularly in critical illnesses such as sepsis or septic shock.""?",False, -15330155,Hydrocortisone produces chronic primary adrenal insufficiency,350,Synacthen test diagnosed Addison's disease with a clear deficiency of cortisol production.,"Is the triple ""Hydrocortisone produces chronic primary adrenal insufficiency"" supported by the sentence: ""Synacthen test diagnosed Addison's disease with a clear deficiency of cortisol production.""?",False, -14100936,Hydrocortisone produces Insulin resistance,351,"Enhanced cortisol production rates, free cortisol, and 11beta-HSD-1 expression correlate with visceral fat and insulin resistance in men: effect of weight loss.","Is the triple ""Hydrocortisone produces Insulin resistance"" supported by the sentence: ""Enhanced cortisol production rates, free cortisol, and 11beta-HSD-1 expression correlate with visceral fat and insulin resistance in men: effect of weight loss.""?",False, -13891079,Hydrocortisone produces obesity disorder,352,"Obesity is also related to dysregulation of cortisol production by the pre-receptor enzyme, 11beta-hydroxysteroid dehydrogenase, and we speculate that this may have a role in the pathogenesis of obesity and raised ICP seen in IIH.","Is the triple ""Hydrocortisone produces obesity disorder"" supported by the sentence: ""Obesity is also related to dysregulation of cortisol production by the pre-receptor enzyme, 11beta-hydroxysteroid dehydrogenase, and we speculate that this may have a role in the pathogenesis of obesity and raised ICP seen in IIH.""?",False, -13796050,Hydrocortisone produces adrenal cortex neoplasm,353,"This is an extremely rare case of bilateral adrenal tumors, in which the left adrenocortical tumor produced and secreted cortisol or both cortisol and aldosterone and the right one produced and secreted both aldosterone and cortisol, as confirmed by clinical findings and pathological studies using immunohistochemical analysis.","Is the triple ""Hydrocortisone produces adrenal cortex neoplasm"" supported by the sentence: ""This is an extremely rare case of bilateral adrenal tumors, in which the left adrenocortical tumor produced and secreted cortisol or both cortisol and aldosterone and the right one produced and secreted both aldosterone and cortisol, as confirmed by clinical findings and pathological studies using immunohistochemical analysis.""?",False, -13783969,Hydrocortisone produces adrenocortical insufficiency,354,"We conclude that the clinical picture of late-onset adrenal insufficiency in preterm infants is not a result of an absolute deficiency of cortisol production, but may be a result of a limited ability to synthesize sufficient cortisol for the degree of clinical stress.","Is the triple ""Hydrocortisone produces adrenocortical insufficiency"" supported by the sentence: ""We conclude that the clinical picture of late-onset adrenal insufficiency in preterm infants is not a result of an absolute deficiency of cortisol production, but may be a result of a limited ability to synthesize sufficient cortisol for the degree of clinical stress.""?",False, -13669597,Hydrocortisone produces asthma,355,"Ironically, despite our understanding of the various stressors that promote chronic adult-onset asthma, most of which are known to elevate cortisol production via the hypothalamic-pituitary-adrenal (HPA) axis, inhaled and systemic corticosteroids are the mainstay for the treatment of chronic asthma.","Is the triple ""Hydrocortisone produces asthma"" supported by the sentence: ""Ironically, despite our understanding of the various stressors that promote chronic adult-onset asthma, most of which are known to elevate cortisol production via the hypothalamic-pituitary-adrenal (HPA) axis, inhaled and systemic corticosteroids are the mainstay for the treatment of chronic asthma.""?",False, -12147996,Hydrocortisone produces Sepsis,356,Glucocorticoid insufficiency is common during sepsis and may result from insufficient production of cortisol or peripheral tissues resistance.,"Is the triple ""Hydrocortisone produces Sepsis"" supported by the sentence: ""Glucocorticoid insufficiency is common during sepsis and may result from insufficient production of cortisol or peripheral tissues resistance.""?",False, -11989948,Hydrocortisone produces Hypoxemia,357,"This likely represents an adaptive response to LTH, to prevent excessive cortisol production that would restrict fetal growth and potentially induce preterm delivery.","Is the triple ""Hydrocortisone produces Hypoxemia"" supported by the sentence: ""This likely represents an adaptive response to LTH, to prevent excessive cortisol production that would restrict fetal growth and potentially induce preterm delivery.""?",False, -11730055,Hydrocortisone produces pneumonia,358,"The reduction in local cortisol production which diminishes the endogenous anti-inflammatory effects, also allows for the progression of both vascular and pulmonary inflammation.","Is the triple ""Hydrocortisone produces pneumonia"" supported by the sentence: ""The reduction in local cortisol production which diminishes the endogenous anti-inflammatory effects, also allows for the progression of both vascular and pulmonary inflammation.""?",False, -8328567,Hydrocortisone produces prostate cancer,359,"CONCLUSIONS: Patients with newly diagnosed, untreated PC yielded significantly higher cortisol and lower estradiol serum concentrations than controls.","Is the triple ""Hydrocortisone produces prostate cancer"" supported by the sentence: ""CONCLUSIONS: Patients with newly diagnosed, untreated PC yielded significantly higher cortisol and lower estradiol serum concentrations than controls.""?",False, -8077250,Hydrocortisone produces neoplasm,360,"The tumour secreted excessive cortisol and dehydroepiandrosterone-sulphate (DHEA-S), and had invaded the right hepatic lobe and vena cava.","Is the triple ""Hydrocortisone produces neoplasm"" supported by the sentence: ""The tumour secreted excessive cortisol and dehydroepiandrosterone-sulphate (DHEA-S), and had invaded the right hepatic lobe and vena cava.""?",False, -27711985,Hydrocortisone disrupts adrenocortical insufficiency,361,Replacement doses of hydrocortisone were administered throughout treatment to counteract potential adrenal insufficiency secondary to the ketoconazole.,"Is the triple ""Hydrocortisone disrupts adrenocortical insufficiency"" supported by the sentence: ""Replacement doses of hydrocortisone were administered throughout treatment to counteract potential adrenal insufficiency secondary to the ketoconazole.""?",False, -26428860,Hydrocortisone disrupts leukemia,362,Amplication by hydrocortisone of the induction of cytotoxic response in vitro to syngeneic murine leukemias.,"Is the triple ""Hydrocortisone disrupts leukemia"" supported by the sentence: ""Amplication by hydrocortisone of the induction of cytotoxic response in vitro to syngeneic murine leukemias.""?",False, -26389045,Hydrocortisone disrupts neoplasm,363,The results demonstrated that the intrarectal dose of indomethacin and hydrocortisone inhibited the development of tumors from microscopic carcinoma lesions in the large bowel and growing further.,"Is the triple ""Hydrocortisone disrupts neoplasm"" supported by the sentence: ""The results demonstrated that the intrarectal dose of indomethacin and hydrocortisone inhibited the development of tumors from microscopic carcinoma lesions in the large bowel and growing further.""?",False, -26128287,Hydrocortisone disrupts melanoma,364,"Growth of ovarian, lung, breast, and kidney carcinomas was increased by 136%, 126%, 78% and 69%, respectively, whereas melanomas, sarcomas, and colon tumors were inhibited by hydrocortisone.","Is the triple ""Hydrocortisone disrupts melanoma"" supported by the sentence: ""Growth of ovarian, lung, breast, and kidney carcinomas was increased by 136%, 126%, 78% and 69%, respectively, whereas melanomas, sarcomas, and colon tumors were inhibited by hydrocortisone.""?",False, -21020907,Hydrocortisone disrupts pneumonia,365,Insufficient cortisol limits the ability of the sick newborn to handle stress and inhibit pulmonary inflammation.,"Is the triple ""Hydrocortisone disrupts pneumonia"" supported by the sentence: ""Insufficient cortisol limits the ability of the sick newborn to handle stress and inhibit pulmonary inflammation.""?",False, -15895489,Hydrocortisone disrupts obesity disorder,366,"BACKGROUND: Hepatic 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) activity, which converts cortisone (inactive) to cortisol, is downregulated in obesity.","Is the triple ""Hydrocortisone disrupts obesity disorder"" supported by the sentence: ""BACKGROUND: Hepatic 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) activity, which converts cortisone (inactive) to cortisol, is downregulated in obesity.""?",False, -15750557,Hydrocortisone disrupts injury,367,"High-dose hydrocortisone treatment given in the first few hours after a traumatic experience was associated with significant favorable changes in the trajectory of exposure to trauma, as expressed by the reduced risk of the development of PTSD post-trauma.","Is the triple ""Hydrocortisone disrupts injury"" supported by the sentence: ""High-dose hydrocortisone treatment given in the first few hours after a traumatic experience was associated with significant favorable changes in the trajectory of exposure to trauma, as expressed by the reduced risk of the development of PTSD post-trauma.""?",False, -8865955,Hydrocortisone disrupts Inflammation,368,"Under normal conditions, stress induces increased cortisol secretion that counteracts inflammatory reactions.","Is the triple ""Hydrocortisone disrupts Inflammation"" supported by the sentence: ""Under normal conditions, stress induces increased cortisol secretion that counteracts inflammatory reactions.""?",False, -26205555,Hydrocortisone prevents neoplasm,369,Hydrocortisone (HC) reduced the macrophage content of four murine tumors to less than half of control values.,"Is the triple ""Hydrocortisone prevents neoplasm"" supported by the sentence: ""Hydrocortisone (HC) reduced the macrophage content of four murine tumors to less than half of control values.""?",False, -19342068,Hydrocortisone prevents obesity disorder,370,"Further, because infant formula contains only trace amounts of glucocorticoids, these findings suggest that cortisol in milk is a novel biological pathway through which breastfeeding may protect against later obesity.","Is the triple ""Hydrocortisone prevents obesity disorder"" supported by the sentence: ""Further, because infant formula contains only trace amounts of glucocorticoids, these findings suggest that cortisol in milk is a novel biological pathway through which breastfeeding may protect against later obesity.""?",False, -19245686,Hydrocortisone prevents toxic shock syndrome,371,"Conclusions and Relevance: Among adults with severe sepsis not in septic shock, use of hydrocortisone compared with placebo did not reduce the risk of septic shock within 14 days.","Is the triple ""Hydrocortisone prevents toxic shock syndrome"" supported by the sentence: ""Conclusions and Relevance: Among adults with severe sepsis not in septic shock, use of hydrocortisone compared with placebo did not reduce the risk of septic shock within 14 days.""?",False, -18758297,Hydrocortisone prevents injury,372,These findings suggest that HC may protect against hyperoxic injury in the developing pulmonary vasculature.,"Is the triple ""Hydrocortisone prevents injury"" supported by the sentence: ""These findings suggest that HC may protect against hyperoxic injury in the developing pulmonary vasculature.""?",False, -17956690,Hydrocortisone prevents Sepsis,373,OBJECTIVE: Cortisol clearance is reduced in sepsis and may contribute to the development of impaired adrenocortical function that is thought to contribute to the pathophysiology of critical illness-related corticosteroid insufficiency.,"Is the triple ""Hydrocortisone prevents Sepsis"" supported by the sentence: ""OBJECTIVE: Cortisol clearance is reduced in sepsis and may contribute to the development of impaired adrenocortical function that is thought to contribute to the pathophysiology of critical illness-related corticosteroid insufficiency.""?",False, -16963888,Hydrocortisone prevents adrenocortical insufficiency,374,Hydrocortisone therapy was started to prevent adrenal insufficiency before laboratory findings for ACTH (adrenocorticotropic hormone) and cortisol levels.,"Is the triple ""Hydrocortisone prevents adrenocortical insufficiency"" supported by the sentence: ""Hydrocortisone therapy was started to prevent adrenal insufficiency before laboratory findings for ACTH (adrenocorticotropic hormone) and cortisol levels.""?",False, -15550113,Hydrocortisone prevents Inflammation,375,CONCLUSION: We conclude that intravenous stress doses of hydrocortisone lead to a reduction of systemic inflammation and to a potential improvement in the early outcome of patients undergoing off-pump CABG.,"Is the triple ""Hydrocortisone prevents Inflammation"" supported by the sentence: ""CONCLUSION: We conclude that intravenous stress doses of hydrocortisone lead to a reduction of systemic inflammation and to a potential improvement in the early outcome of patients undergoing off-pump CABG.""?",False, -15540854,Hydrocortisone prevents pneumonia,376,"CONCLUSION: In intubated trauma patients, the use of an intravenous stress-dose of hydrocortisone, compared with placebo, resulted in a decreased risk of hospital-acquired pneumonia.","Is the triple ""Hydrocortisone prevents pneumonia"" supported by the sentence: ""CONCLUSION: In intubated trauma patients, the use of an intravenous stress-dose of hydrocortisone, compared with placebo, resulted in a decreased risk of hospital-acquired pneumonia.""?",False, -14020540,Hydrocortisone prevents bronchopulmonary dysplasia,377,"Early hydrocortisone (HC) treatment may decrease the incidence of bronchopulmonary dysplasia; however, the long-term effects are still under evaluation.","Is the triple ""Hydrocortisone prevents bronchopulmonary dysplasia"" supported by the sentence: ""Early hydrocortisone (HC) treatment may decrease the incidence of bronchopulmonary dysplasia; however, the long-term effects are still under evaluation.""?",False, -13075196,Hydrocortisone prevents atrial fibrillation,378,CONCLUSION: Intravenous hydrocortisone reduced the incidence of AF after cardiac surgery.,"Is the triple ""Hydrocortisone prevents atrial fibrillation"" supported by the sentence: ""CONCLUSION: Intravenous hydrocortisone reduced the incidence of AF after cardiac surgery.""?",False, -12187318,Hydrocortisone prevents Insulin resistance,379,"Assuming a single dose of hydrocortisone improves sensitivity of peripheral tissues to insulin, it may be an interesting candidate for use in reducing insulin resistance in peripheral tissues of horses with several disease states.","Is the triple ""Hydrocortisone prevents Insulin resistance"" supported by the sentence: ""Assuming a single dose of hydrocortisone improves sensitivity of peripheral tissues to insulin, it may be an interesting candidate for use in reducing insulin resistance in peripheral tissues of horses with several disease states.""?",False, -14643692,Hydrocortisone exacerbates Sepsis,380,Plasma cortisol and glucagon concentrations were not increased markedly except in a case complicated other systemic bacterial infection.,"Is the triple ""Hydrocortisone exacerbates Sepsis"" supported by the sentence: ""Plasma cortisol and glucagon concentrations were not increased markedly except in a case complicated other systemic bacterial infection.""?",False, -8122784,Hydrocortisone exacerbates obesity disorder,381,"In view of the stimulatory effects of insulin and cortisol on adipogenesis, long-term stimulation of 11betaHSD reductase activity by insulin could aggravate visceral obesity.","Is the triple ""Hydrocortisone exacerbates obesity disorder"" supported by the sentence: ""In view of the stimulatory effects of insulin and cortisol on adipogenesis, long-term stimulation of 11betaHSD reductase activity by insulin could aggravate visceral obesity.""?",False, -25411585,Hydrocortisone predisposes atrial fibrillation,382,"For this purpose, this review article contends that plasma cortisol is linked to a greater risk of AF.","Is the triple ""Hydrocortisone predisposes atrial fibrillation"" supported by the sentence: ""For this purpose, this review article contends that plasma cortisol is linked to a greater risk of AF.""?",False, -19755964,Hydrocortisone predisposes Sepsis,383,"After multivariate analysis, duration of HC stress dose administration was associated with increased risk of mortality (OR 1.11, 95% CI 1.02-1.2, p = 0.021), and total duration of HC treatment was associated with increased risk of sepsis (OR 1.04, 95% CI 1.005-1.075, p = 0.026).","Is the triple ""Hydrocortisone predisposes Sepsis"" supported by the sentence: ""After multivariate analysis, duration of HC stress dose administration was associated with increased risk of mortality (OR 1.11, 95% CI 1.02-1.2, p = 0.021), and total duration of HC treatment was associated with increased risk of sepsis (OR 1.04, 95% CI 1.005-1.075, p = 0.026).""?",False, -13712588,Hydrocortisone predisposes injury,384,"Plasma leptin and ghrelin levels in endotoxin-treated dogs were correlated with serum nitric oxide (r = .955 and r = .890; p < .001), procalcitonin (r = .825 and r = .716; p < .001), cortisol (r = .823 and r = .786; p < .001), and hepatorenal injury markers (r = .580 to .745 and r = .393 to .574; p < .05 to .01).","Is the triple ""Hydrocortisone predisposes injury"" supported by the sentence: ""Plasma leptin and ghrelin levels in endotoxin-treated dogs were correlated with serum nitric oxide (r = .955 and r = .890; p < .001), procalcitonin (r = .825 and r = .716; p < .001), cortisol (r = .823 and r = .786; p < .001), and hepatorenal injury markers (r = .580 to .745 and r = .393 to .574; p < .05 to .01).""?",False, -12555774,Hydrocortisone predisposes toxic shock syndrome,385,Contribution of cortisol deficiency to septic shock.,"Is the triple ""Hydrocortisone predisposes toxic shock syndrome"" supported by the sentence: ""Contribution of cortisol deficiency to septic shock.""?",False, -11782928,Hydrocortisone predisposes Inflammation,386,The objective of this study was to demonstrate the effect of stress doses of hydrocortisone during the initial phase of human septic shock on the serum values of the neurospecific protein S-100B in comparison to the inflammation markers interleukin (IL)-8 in serum and polymorphonuclear (PMN) elastase in plasma.,"Is the triple ""Hydrocortisone predisposes Inflammation"" supported by the sentence: ""The objective of this study was to demonstrate the effect of stress doses of hydrocortisone during the initial phase of human septic shock on the serum values of the neurospecific protein S-100B in comparison to the inflammation markers interleukin (IL)-8 in serum and polymorphonuclear (PMN) elastase in plasma.""?",False, -10520517,Hydrocortisone predisposes obesity disorder,387,"The synergism between insulin and cortisol in stimulating energy deposition, associated with a decreased effect of corticotropin-releasing factor in stimulating energy expenditure, is likely to contribute to the development of obesity.","Is the triple ""Hydrocortisone predisposes obesity disorder"" supported by the sentence: ""The synergism between insulin and cortisol in stimulating energy deposition, associated with a decreased effect of corticotropin-releasing factor in stimulating energy expenditure, is likely to contribute to the development of obesity.""?",False, -8615556,Hydrocortisone predisposes dissociative amnesia,388,Higher basal cortisol predicts verbal memory loss in postmenopausal women: Rancho Bernardo Study.,"Is the triple ""Hydrocortisone predisposes dissociative amnesia"" supported by the sentence: ""Higher basal cortisol predicts verbal memory loss in postmenopausal women: Rancho Bernardo Study.""?",False, -8552834,Hydrocortisone predisposes asthma,389,"A growing body of evidence now suggests that endogenous cortisol, which is produced in significant quantities by the body in a diurnal rhythm, is an important regulator of allergic disease expression and allergic inflammatory responses: lung function varies along with plasma cortisol levels; the number of circulating inflammatory cells varies with plasma cortisol levels; and low levels of endogenous cortisol may be associated with risk for asthma.","Is the triple ""Hydrocortisone predisposes asthma"" supported by the sentence: ""A growing body of evidence now suggests that endogenous cortisol, which is produced in significant quantities by the body in a diurnal rhythm, is an important regulator of allergic disease expression and allergic inflammatory responses: lung function varies along with plasma cortisol levels; the number of circulating inflammatory cells varies with plasma cortisol levels; and low levels of endogenous cortisol may be associated with risk for asthma.""?",False, -8002300,Hydrocortisone predisposes Insulin resistance,390,"In conclusion, the data presented here suggest that cortisol can contribute to insulin resistance in ponies with hyperlipoproteinaemia.","Is the triple ""Hydrocortisone predisposes Insulin resistance"" supported by the sentence: ""In conclusion, the data presented here suggest that cortisol can contribute to insulin resistance in ponies with hyperlipoproteinaemia.""?",False, -7960726,Hydrocortisone predisposes pneumonia,391,"OBJECTIVE: To investigate the relationship of cortisol concentrations during the first week of life to patent ductus arteriosus (PDA), markers of lung inflammation, and respiratory outcome in very low birth weight infants.","Is the triple ""Hydrocortisone predisposes pneumonia"" supported by the sentence: ""OBJECTIVE: To investigate the relationship of cortisol concentrations during the first week of life to patent ductus arteriosus (PDA), markers of lung inflammation, and respiratory outcome in very low birth weight infants.""?",False, -27228384,Methylprednisolone related to Crohn disease,392,Oral pH-modified release budesonide versus 6-methylprednisolone in active Crohn's disease.,"Is the triple ""Methylprednisolone related to Crohn disease"" supported by the sentence: ""Oral pH-modified release budesonide versus 6-methylprednisolone in active Crohn's disease.""?",False, -26974005,Methylprednisolone related to hematopoietic and lymphoid system neoplasm,393,Pharmacokinetics of high dose methylprednisolone and use in hematological malignancies.,"Is the triple ""Methylprednisolone related to hematopoietic and lymphoid system neoplasm"" supported by the sentence: ""Pharmacokinetics of high dose methylprednisolone and use in hematological malignancies.""?",False, -26513818,Methylprednisolone related to B-cell chronic lymphocytic leukemia,394,"Methylprednisolone in advanced chronic lymphocytic leukaemia: rationale for, and effectiveness of treatment suggested by DiSC assay.","Is the triple ""Methylprednisolone related to B-cell chronic lymphocytic leukemia"" supported by the sentence: ""Methylprednisolone in advanced chronic lymphocytic leukaemia: rationale for, and effectiveness of treatment suggested by DiSC assay.""?",False, -26050805,Methylprednisolone related to ankylosing spondylitis,395,The effects of intravenous pulse methylprednisolone on immunological and inflammatory processes in ankylosing spondylitis.,"Is the triple ""Methylprednisolone related to ankylosing spondylitis"" supported by the sentence: ""The effects of intravenous pulse methylprednisolone on immunological and inflammatory processes in ankylosing spondylitis.""?",False, -25845844,Methylprednisolone related to breast neoplasm,396,The effect of methylprednisolone (MP) on the cell kinetic response to cyclophosphamide (CP) and Adriamycin (ADR) in C3H/HeJ spontaneous mammary tumors and hematopoietic tissue was investigated.,"Is the triple ""Methylprednisolone related to breast neoplasm"" supported by the sentence: ""The effect of methylprednisolone (MP) on the cell kinetic response to cyclophosphamide (CP) and Adriamycin (ADR) in C3H/HeJ spontaneous mammary tumors and hematopoietic tissue was investigated.""?",False, -25642837,Methylprednisolone related to dermatomyositis,397,High-dose intravenous methyl-prednisolone in chronic polymyositis/dermatomyositis.,"Is the triple ""Methylprednisolone related to dermatomyositis"" supported by the sentence: ""High-dose intravenous methyl-prednisolone in chronic polymyositis/dermatomyositis.""?",False, -25328503,Methylprednisolone related to Meniere disease,398,Comparing Intratympanic Gentamicin with Methylprednisolone in Meniere's Disease with Non-Serviceable Hearing.,"Is the triple ""Methylprednisolone related to Meniere disease"" supported by the sentence: ""Comparing Intratympanic Gentamicin with Methylprednisolone in Meniere's Disease with Non-Serviceable Hearing.""?",False, -24759961,Methylprednisolone related to non-Hodgkin lymphoma,399,"High-dose methylprednisolone, vincristine, MTX, and ara-C (SOMA) as initial bulk reducing therapy in non-Hodgkin's lymphoma of unfavorable histology: preliminary results of an ongoing phase II study.","Is the triple ""Methylprednisolone related to non-Hodgkin lymphoma"" supported by the sentence: ""High-dose methylprednisolone, vincristine, MTX, and ara-C (SOMA) as initial bulk reducing therapy in non-Hodgkin's lymphoma of unfavorable histology: preliminary results of an ongoing phase II study.""?",False, -24691450,Methylprednisolone related to plantar fasciitis,400,A Prospective Study Comparing the Efficacy of Local Injection of Platelet-Rich Plasma (PRP) vs Methylprednisolone in Plantar Fasciitis.,"Is the triple ""Methylprednisolone related to plantar fasciitis"" supported by the sentence: ""A Prospective Study Comparing the Efficacy of Local Injection of Platelet-Rich Plasma (PRP) vs Methylprednisolone in Plantar Fasciitis.""?",False, -24586108,Methylprednisolone related to alcoholic hepatitis,401,A controlled trial of 6-methylprednisolone in acute alcoholic hepatitis.,"Is the triple ""Methylprednisolone related to alcoholic hepatitis"" supported by the sentence: ""A controlled trial of 6-methylprednisolone in acute alcoholic hepatitis.""?",False, -24559507,Methylprednisolone related to respiratory system disorder,402,[Short-term therapy with methylprednisolone in exacerbated obstructive respiratory tract diseases].,"Is the triple ""Methylprednisolone related to respiratory system disorder"" supported by the sentence: ""[Short-term therapy with methylprednisolone in exacerbated obstructive respiratory tract diseases].""?",False, -23573980,Methylprednisolone related to pneumonia,403,Methylprednisolone and 60 Days in Hospital Survival in Coronavirus Disease 2019 Pneumonia.,"Is the triple ""Methylprednisolone related to pneumonia"" supported by the sentence: ""Methylprednisolone and 60 Days in Hospital Survival in Coronavirus Disease 2019 Pneumonia.""?",False, -23514846,Methylprednisolone related to carpal tunnel syndrome,404,Intra-Carpal Injection of Ozone versus Methylprednisolone in Carpal Tunnel Syndrome of Systemic Sclerosis Patients: A Randomized Single-Blind Clinical Trial.,"Is the triple ""Methylprednisolone related to carpal tunnel syndrome"" supported by the sentence: ""Intra-Carpal Injection of Ozone versus Methylprednisolone in Carpal Tunnel Syndrome of Systemic Sclerosis Patients: A Randomized Single-Blind Clinical Trial.""?",False, -23364897,Methylprednisolone related to West syndrome,405,Methylprednisolone Pulses in West Syndrome: A New Weapon in the Armory-Is it Needed?,"Is the triple ""Methylprednisolone related to West syndrome"" supported by the sentence: ""Methylprednisolone Pulses in West Syndrome: A New Weapon in the Armory-Is it Needed?""?",False, -22495910,Methylprednisolone related to myocarditis,406,Patient underwent treatment with milrinone and methylprednisolone that showed reduction in myocardial inflammation and significantly improved myocardial contractility.,"Is the triple ""Methylprednisolone related to myocarditis"" supported by the sentence: ""Patient underwent treatment with milrinone and methylprednisolone that showed reduction in myocardial inflammation and significantly improved myocardial contractility.""?",False, -22175056,Methylprednisolone related to myopathy,407,"Neurologically, the therapeutic dosages of anticoagulants are linked to the high incidence of thrombotic complexities, while methylprednisolone is associated with myopathy.","Is the triple ""Methylprednisolone related to myopathy"" supported by the sentence: ""Neurologically, the therapeutic dosages of anticoagulants are linked to the high incidence of thrombotic complexities, while methylprednisolone is associated with myopathy.""?",False, -20879022,Methylprednisolone related to Pain,408,"Conclusion: Based on the current data, the efficacy and safety of local injection of triamcinolone and methylprednisolone at doses of 20 and 40 mg were associated with a significant improvement in pain, functional status, and strength.","Is the triple ""Methylprednisolone related to Pain"" supported by the sentence: ""Conclusion: Based on the current data, the efficacy and safety of local injection of triamcinolone and methylprednisolone at doses of 20 and 40 mg were associated with a significant improvement in pain, functional status, and strength.""?",False, -20342058,Methylprednisolone related to chronic progressive multiple sclerosis,409,OBJECTIVE: To validate the responsiveness of cerebrospinal fluid (CSF) inflammatory biomarkers to treatment with natalizumab and methylprednisolone in progressive MS and to examine the relationship between CSF inflammatory and tissue damage biomarkers.,"Is the triple ""Methylprednisolone related to chronic progressive multiple sclerosis"" supported by the sentence: ""OBJECTIVE: To validate the responsiveness of cerebrospinal fluid (CSF) inflammatory biomarkers to treatment with natalizumab and methylprednisolone in progressive MS and to examine the relationship between CSF inflammatory and tissue damage biomarkers.""?",False, -20290784,Methylprednisolone related to membranous glomerulonephritis,410,The region was identified as a significant predictor of use of intravenous methylprednisolone in MCD and MN patients.,"Is the triple ""Methylprednisolone related to membranous glomerulonephritis"" supported by the sentence: ""The region was identified as a significant predictor of use of intravenous methylprednisolone in MCD and MN patients.""?",False, -20286711,Methylprednisolone related to neuromyelitis optica,411,"Clinical commentary on ""Two cases of anaphylactic shock by methylprednisolone in neuromyelitis optica"".","Is the triple ""Methylprednisolone related to neuromyelitis optica"" supported by the sentence: ""Clinical commentary on ""Two cases of anaphylactic shock by methylprednisolone in neuromyelitis optica"".""?",False, -19340184,Methylprednisolone related to chronic obstructive pulmonary disease,412,CONCLUSION: Results show that inhalation of budesonide (2 mg 3 times/day) and systemic methylprednisolone (40 mg/day) had similar clinical outcome in AECOPD.,"Is the triple ""Methylprednisolone related to chronic obstructive pulmonary disease"" supported by the sentence: ""CONCLUSION: Results show that inhalation of budesonide (2 mg 3 times/day) and systemic methylprednisolone (40 mg/day) had similar clinical outcome in AECOPD.""?",False, -18938435,Methylprednisolone related to graft versus host disease,413,A Clinical Trial Comparing the Safety and Efficacy of Topical Tacrolimus versus Methylprednisolone in Ocular Graft-versus-Host Disease.,"Is the triple ""Methylprednisolone related to graft versus host disease"" supported by the sentence: ""A Clinical Trial Comparing the Safety and Efficacy of Topical Tacrolimus versus Methylprednisolone in Ocular Graft-versus-Host Disease.""?",False, -17333962,Methylprednisolone related to Inflammation,414,The purpose of this study was to evaluate the efficacy of supraperiosteal injection of methylprednisolone compared with an oral tablet form and intravenous (i.v.) injection in the prevention of postoperative pain and oedema associated with inflammation.,"Is the triple ""Methylprednisolone related to Inflammation"" supported by the sentence: ""The purpose of this study was to evaluate the efficacy of supraperiosteal injection of methylprednisolone compared with an oral tablet form and intravenous (i.v.) injection in the prevention of postoperative pain and oedema associated with inflammation.""?",False, -17288506,Methylprednisolone related to autoimmune thrombocytopenic purpura,415,Gamma globulin and methylprednisolone in idiopathic thrombocytopenic purpura.,"Is the triple ""Methylprednisolone related to autoimmune thrombocytopenic purpura"" supported by the sentence: ""Gamma globulin and methylprednisolone in idiopathic thrombocytopenic purpura.""?",False, -15936572,Methylprednisolone related to endocrine exophthalmos,416,Methylprednisolone and hepatotoxicity in Graves' ophthalmopathy.,"Is the triple ""Methylprednisolone related to endocrine exophthalmos"" supported by the sentence: ""Methylprednisolone and hepatotoxicity in Graves' ophthalmopathy.""?",False, -15072844,Methylprednisolone related to Edema,417,"In orthognathic surgery, methylprednisolone > or =85 mg administered intravenously seemed sufficient to produce a significant decrease in edema, and several trials pointed toward a neuroregeneration effect, but no statistical analysis could be performed.","Is the triple ""Methylprednisolone related to Edema"" supported by the sentence: ""In orthognathic surgery, methylprednisolone > or =85 mg administered intravenously seemed sufficient to produce a significant decrease in edema, and several trials pointed toward a neuroregeneration effect, but no statistical analysis could be performed.""?",False, -14876749,Methylprednisolone related to osteoarthritis,418,Response of symptoms and synovitis to intra-muscular methylprednisolone in osteoarthritis of the hand: an ultrasonographic study.,"Is the triple ""Methylprednisolone related to osteoarthritis"" supported by the sentence: ""Response of symptoms and synovitis to intra-muscular methylprednisolone in osteoarthritis of the hand: an ultrasonographic study.""?",False, -14399082,Methylprednisolone related to aplastic anemia,419,Long-term results of high-dose methylprednisolone in aplastic anemia.,"Is the triple ""Methylprednisolone related to aplastic anemia"" supported by the sentence: ""Long-term results of high-dose methylprednisolone in aplastic anemia.""?",False, -14398237,Methylprednisolone related to IgA glomerulonephritis,420,"Efficacy of methylprednisolone, cyclophosphamide in pediatric IgA nephropathy assessed by renal biopsy.","Is the triple ""Methylprednisolone related to IgA glomerulonephritis"" supported by the sentence: ""Efficacy of methylprednisolone, cyclophosphamide in pediatric IgA nephropathy assessed by renal biopsy.""?",False, -14278238,"Methylprednisolone related to dermatitis, atopic",421,"The impaired effect on lymphocyte blastogenesis of glucocorticoids administered in vivo, in contrast to a normal in vitro reaction to dexamethasone, together with recent findings of an altered glucocorticoid receptor pharmacology in AD, points to a decreased biological in vivo efficiency of methylprednisolone in atopic dermatitis.","Is the triple ""Methylprednisolone related to dermatitis, atopic"" supported by the sentence: ""The impaired effect on lymphocyte blastogenesis of glucocorticoids administered in vivo, in contrast to a normal in vitro reaction to dexamethasone, together with recent findings of an altered glucocorticoid receptor pharmacology in AD, points to a decreased biological in vivo efficiency of methylprednisolone in atopic dermatitis.""?",False, -14166179,Methylprednisolone related to cardiac arrest,422,"CONCLUSION: In this single-center trial, combined vasopressin-epinephrine and methylprednisolone during resuscitation and stress-dose hydrocortisone in postresuscitation shock improved survival in refractory in-hospital cardiac arrest.","Is the triple ""Methylprednisolone related to cardiac arrest"" supported by the sentence: ""CONCLUSION: In this single-center trial, combined vasopressin-epinephrine and methylprednisolone during resuscitation and stress-dose hydrocortisone in postresuscitation shock improved survival in refractory in-hospital cardiac arrest.""?",False, -12755316,Methylprednisolone related to plasma cell myeloma,423,Weekly bortezomib/methylprednisolone is effective and well tolerated in relapsed multiple myeloma.,"Is the triple ""Methylprednisolone related to plasma cell myeloma"" supported by the sentence: ""Weekly bortezomib/methylprednisolone is effective and well tolerated in relapsed multiple myeloma.""?",False, -12183687,Methylprednisolone related to acute lymphoblastic leukemia,424,Amsacrine combined with etoposide and high-dose methylprednisolone as salvage therapy in acute lymphoblastic leukemia in children.,"Is the triple ""Methylprednisolone related to acute lymphoblastic leukemia"" supported by the sentence: ""Amsacrine combined with etoposide and high-dose methylprednisolone as salvage therapy in acute lymphoblastic leukemia in children.""?",False, -11720471,Methylprednisolone related to systemic lupus erythematosus,425,Controlled clinical trial of IV cyclophosphamide versus IV methylprednisolone in severe neurological manifestations in systemic lupus erythematosus.,"Is the triple ""Methylprednisolone related to systemic lupus erythematosus"" supported by the sentence: ""Controlled clinical trial of IV cyclophosphamide versus IV methylprednisolone in severe neurological manifestations in systemic lupus erythematosus.""?",False, -10812685,Methylprednisolone related to immunoglobulin a vasculitis,426,Delayed hypersensitivity to 6-methyl-prednisolone in Henoch Schoenlein syndrome.,"Is the triple ""Methylprednisolone related to immunoglobulin a vasculitis"" supported by the sentence: ""Delayed hypersensitivity to 6-methyl-prednisolone in Henoch Schoenlein syndrome.""?",False, -10763477,Methylprednisolone related to ulcerative colitis,427,Rectal absorption of radioactive 6-alpha-methyl prednisolone in ulcerative colitis.,"Is the triple ""Methylprednisolone related to ulcerative colitis"" supported by the sentence: ""Rectal absorption of radioactive 6-alpha-methyl prednisolone in ulcerative colitis.""?",False, -10558884,Methylprednisolone related to lupus nephritis,428,Controlled trial of pulse methylprednisolone versus two regimens of pulse cyclophosphamide in severe lupus nephritis.,"Is the triple ""Methylprednisolone related to lupus nephritis"" supported by the sentence: ""Controlled trial of pulse methylprednisolone versus two regimens of pulse cyclophosphamide in severe lupus nephritis.""?",False, -10130342,Methylprednisolone related to adult acute respiratory distress syndrome,429,"The National Heart, Lung, and Blood Institute's ARDS Network currently is testing the use of methylprednisolone in late ARDS.","Is the triple ""Methylprednisolone related to adult acute respiratory distress syndrome"" supported by the sentence: ""The National Heart, Lung, and Blood Institute's ARDS Network currently is testing the use of methylprednisolone in late ARDS.""?",False, -9229208,Methylprednisolone related to vestibular neuronitis,430,"(3) Preliminary results of an interim analysis from an ongoing randomized, prospective study showed that methylprednisolone (plus an antiviral agent?) may be useful for improving peripheral vestibular function in vestibular neuritis.","Is the triple ""Methylprednisolone related to vestibular neuronitis"" supported by the sentence: ""(3) Preliminary results of an interim analysis from an ongoing randomized, prospective study showed that methylprednisolone (plus an antiviral agent?) may be useful for improving peripheral vestibular function in vestibular neuritis.""?",False, -9003326,Methylprednisolone related to systemic sclerosis,431,This is the first report of cyclophosphamide and methylprednisolone leading to complete and sustained resolution of GAVE in association with systemic sclerosis.,"Is the triple ""Methylprednisolone related to systemic sclerosis"" supported by the sentence: ""This is the first report of cyclophosphamide and methylprednisolone leading to complete and sustained resolution of GAVE in association with systemic sclerosis.""?",False, -8447481,Methylprednisolone related to rheumatoid arthritis,432,We compared lymphocyte-suppressive potencies of prednisolone and methylprednisolone in rheumatoid arthritis (RA).,"Is the triple ""Methylprednisolone related to rheumatoid arthritis"" supported by the sentence: ""We compared lymphocyte-suppressive potencies of prednisolone and methylprednisolone in rheumatoid arthritis (RA).""?",False, -8282330,Methylprednisolone related to spinal cord injury,433,"Despite the lucrative ""off label"" markets for methylprednisolone in SCI, no Food and Drug Association indication has been obtained.","Is the triple ""Methylprednisolone related to spinal cord injury"" supported by the sentence: ""Despite the lucrative ""off label"" markets for methylprednisolone in SCI, no Food and Drug Association indication has been obtained.""?",False, -7944646,Methylprednisolone related to myasthenia gravis,434,Extraocular muscle responses to high dose intravenous methylprednisolone in myasthenia gravis.,"Is the triple ""Methylprednisolone related to myasthenia gravis"" supported by the sentence: ""Extraocular muscle responses to high dose intravenous methylprednisolone in myasthenia gravis.""?",False, -7668599,Methylprednisolone related to multiple sclerosis,435,The increased CSF levels of TNF-sRp55 in response to MP circumstantially suggest that this receptor could partially account for the beneficial effects of MP in acute MS.,"Is the triple ""Methylprednisolone related to multiple sclerosis"" supported by the sentence: ""The increased CSF levels of TNF-sRp55 in response to MP circumstantially suggest that this receptor could partially account for the beneficial effects of MP in acute MS.""?",False, -7443745,Methylprednisolone related to asthma,436,"Such an effect has been demonstrated between clarithromycin and methylprednisolone, two drugs that may be administered concomitantly in asthma.","Is the triple ""Methylprednisolone related to asthma"" supported by the sentence: ""Such an effect has been demonstrated between clarithromycin and methylprednisolone, two drugs that may be administered concomitantly in asthma.""?",False, -24973247,Methylprednisolone causes lupus nephritis,437,"In this study, low-dose methylprednisolone (0.8 mg/kg/day, MP) was used to induce a steroid-resistant lupus nephritis (SR-LN) mouse model in weeks one to four, and a therapeutic steroid dosage (MP 12 mg/kg/day) or a combined PNS (PNS 100 mg/kg/day) treatment was administered from week five to eight.","Is the triple ""Methylprednisolone causes lupus nephritis"" supported by the sentence: ""In this study, low-dose methylprednisolone (0.8 mg/kg/day, MP) was used to induce a steroid-resistant lupus nephritis (SR-LN) mouse model in weeks one to four, and a therapeutic steroid dosage (MP 12 mg/kg/day) or a combined PNS (PNS 100 mg/kg/day) treatment was administered from week five to eight.""?",False, -24161886,Methylprednisolone causes Edema,438,MP was administrated in three alternative ways: intraperitoneally during the induction of cytotoxic edema or immediately after finishing cytotoxic edema induction in a dose of 100 mg/kg b.w.; into the internal carotid artery within 2 h after finishing cytotoxic edema induction in a dose of 50 mg/kg b.w.; into internal carotid artery 10 min after edema induction by BBBd in a dose of 50 mg/kg b.w.,"Is the triple ""Methylprednisolone causes Edema"" supported by the sentence: ""MP was administrated in three alternative ways: intraperitoneally during the induction of cytotoxic edema or immediately after finishing cytotoxic edema induction in a dose of 100 mg/kg b.w.; into the internal carotid artery within 2 h after finishing cytotoxic edema induction in a dose of 50 mg/kg b.w.; into internal carotid artery 10 min after edema induction by BBBd in a dose of 50 mg/kg b.w.""?",False, -18534953,Methylprednisolone causes Inflammation,439,"On the other hand, daily administration of methylprednisolone and tenoxicam for 4 weeks caused increased inflammation and fibrosis and wasn't affective on protection of nerve physiomorphology.","Is the triple ""Methylprednisolone causes Inflammation"" supported by the sentence: ""On the other hand, daily administration of methylprednisolone and tenoxicam for 4 weeks caused increased inflammation and fibrosis and wasn't affective on protection of nerve physiomorphology.""?",False, -18260665,Methylprednisolone causes neoplasm,440,Methylprednisolone was temporarily stopped while a broad work up for inflammatory and neoplastic causes was pursued.,"Is the triple ""Methylprednisolone causes neoplasm"" supported by the sentence: ""Methylprednisolone was temporarily stopped while a broad work up for inflammatory and neoplastic causes was pursued.""?",False, -17307095,Methylprednisolone causes pneumonia,441,"Pneumocystis pneumonia induced by this dose of tacrolimus has been reported in many cases; however, we encountered a rare case of Pneumocystis pneumonia induced by low-dose tacrolimus and methylprednisolone.","Is the triple ""Methylprednisolone causes pneumonia"" supported by the sentence: ""Pneumocystis pneumonia induced by this dose of tacrolimus has been reported in many cases; however, we encountered a rare case of Pneumocystis pneumonia induced by low-dose tacrolimus and methylprednisolone.""?",False, -15906641,Methylprednisolone causes Pain,442,The increased interval in the administration of MP resulted in slightly greater pain and an increased prevalence of NeP.,"Is the triple ""Methylprednisolone causes Pain"" supported by the sentence: ""The increased interval in the administration of MP resulted in slightly greater pain and an increased prevalence of NeP.""?",False, -13166073,Methylprednisolone causes thrombocytopenia,443,"We describe that high-dose methylprednisolone (20 mg/kg) can induce multifocal osteonecrosis (ON) in conjunction with thrombocytopenia, hypofibrinogenemia, and hyperlipemia.","Is the triple ""Methylprednisolone causes thrombocytopenia"" supported by the sentence: ""We describe that high-dose methylprednisolone (20 mg/kg) can induce multifocal osteonecrosis (ON) in conjunction with thrombocytopenia, hypofibrinogenemia, and hyperlipemia.""?",False, -12672767,Methylprednisolone causes drug-induced liver injury,444,"OBJECTIVE: To report the third published case, as of April 8, 2006, of methylprednisolone-induced toxic hepatitis.","Is the triple ""Methylprednisolone causes drug-induced liver injury"" supported by the sentence: ""OBJECTIVE: To report the third published case, as of April 8, 2006, of methylprednisolone-induced toxic hepatitis.""?",False, -8525599,Methylprednisolone causes myopathy,445,"To our knowledge, this is the first discussion considering the possibility that the methylprednisolone recommended by NASCIS may cause acute corticosteroid myopathy.","Is the triple ""Methylprednisolone causes myopathy"" supported by the sentence: ""To our knowledge, this is the first discussion considering the possibility that the methylprednisolone recommended by NASCIS may cause acute corticosteroid myopathy.""?",False, -27357949,Methylprednisolone affects neoplasm,446,"However, high-dose steroids like dexamethasone or methylprednisolone had proven their clearcut anti-tumoral action.","Is the triple ""Methylprednisolone affects neoplasm"" supported by the sentence: ""However, high-dose steroids like dexamethasone or methylprednisolone had proven their clearcut anti-tumoral action.""?",False, -24420470,Methylprednisolone affects Inflammation,447,"Methylprednisolone increases some astrogliosis and inflammation biomarkers' levels; however, it did not affect the apoptotic biomarkers.","Is the triple ""Methylprednisolone affects Inflammation"" supported by the sentence: ""Methylprednisolone increases some astrogliosis and inflammation biomarkers' levels; however, it did not affect the apoptotic biomarkers.""?",False, -23472756,Methylprednisolone affects Inflammation,448,Effect of Methylprednisolone on Inflammation and Coagulation in Patients with Severe COVID-19: A Retrospective Cohort Study.,"Is the triple ""Methylprednisolone affects Inflammation"" supported by the sentence: ""Effect of Methylprednisolone on Inflammation and Coagulation in Patients with Severe COVID-19: A Retrospective Cohort Study.""?",False, -20530617,Methylprednisolone affects systemic sclerosis,449,"METHODS/DESIGN: This study is a 12-week, randomised, double-blind, placebo-controlled trial analysing the effects of high-dose intravenous methylprednisolone in very early SSc.","Is the triple ""Methylprednisolone affects systemic sclerosis"" supported by the sentence: ""METHODS/DESIGN: This study is a 12-week, randomised, double-blind, placebo-controlled trial analysing the effects of high-dose intravenous methylprednisolone in very early SSc.""?",False, -20254789,Methylprednisolone affects adult acute respiratory distress syndrome,450,"Methods: The potential interferences Se@SiO2 nanocomposites may have to the therapeutic effect of methylprednisolone (MPS) were evaluated by classical therapeutic effect index of acute respiratory distress syndrome (ARDS), such as wet-to-dry weight ratio, inflammatory factors IL-1beta and TNF-alpha.","Is the triple ""Methylprednisolone affects adult acute respiratory distress syndrome"" supported by the sentence: ""Methods: The potential interferences Se@SiO2 nanocomposites may have to the therapeutic effect of methylprednisolone (MPS) were evaluated by classical therapeutic effect index of acute respiratory distress syndrome (ARDS), such as wet-to-dry weight ratio, inflammatory factors IL-1beta and TNF-alpha.""?",False, -17649050,Methylprednisolone affects optic nerve disorder,451,Our case likely represents worsening of DON due to soft tissue swelling secondary to OR despite cover with IVMP in a patient previously responsive to IVMP alone.,"Is the triple ""Methylprednisolone affects optic nerve disorder"" supported by the sentence: ""Our case likely represents worsening of DON due to soft tissue swelling secondary to OR despite cover with IVMP in a patient previously responsive to IVMP alone.""?",False, -16634377,Methylprednisolone affects myasthenia gravis,452,[Treatment of invasive thymoma with myasthenia gravis: a case report responsive to azathioprine and methylprednisolone].,"Is the triple ""Methylprednisolone affects myasthenia gravis"" supported by the sentence: ""[Treatment of invasive thymoma with myasthenia gravis: a case report responsive to azathioprine and methylprednisolone].""?",False, -16277488,Methylprednisolone affects neuromyelitis optica,453,High-dose intravenous methylprednisolone is the first-line therapy for acute exacerbations of NMO.,"Is the triple ""Methylprednisolone affects neuromyelitis optica"" supported by the sentence: ""High-dose intravenous methylprednisolone is the first-line therapy for acute exacerbations of NMO.""?",False, -15906642,Methylprednisolone affects Pain,454,"CONCLUSION: Although the delayed administration of high-dose MP did not significantly increase the severity of pain or prevalence of NeP, it should still be avoided due to the increased risk of serious side effects.","Is the triple ""Methylprednisolone affects Pain"" supported by the sentence: ""CONCLUSION: Although the delayed administration of high-dose MP did not significantly increase the severity of pain or prevalence of NeP, it should still be avoided due to the increased risk of serious side effects.""?",False, -15610554,Methylprednisolone affects rheumatoid arthritis,455,Methylprednisolone has been used in other Th1 mediated diseases such as rheumatoid arthritis in an attempt to switch off the immune response and so we investigated the efficacy of three days of high dose (1 g) intravenous methylprednisolone at the start of prednisolone therapy in leprosy Type 1 reactions and nerve function impairment.,"Is the triple ""Methylprednisolone affects rheumatoid arthritis"" supported by the sentence: ""Methylprednisolone has been used in other Th1 mediated diseases such as rheumatoid arthritis in an attempt to switch off the immune response and so we investigated the efficacy of three days of high dose (1 g) intravenous methylprednisolone at the start of prednisolone therapy in leprosy Type 1 reactions and nerve function impairment.""?",False, -15186368,Methylprednisolone affects graft versus host disease,456,Myelitis in these patients was not related to graft versus host disease or immune reconstitution and was responsive to intravenous methylprednisolone and cyclophosphamide.,"Is the triple ""Methylprednisolone affects graft versus host disease"" supported by the sentence: ""Myelitis in these patients was not related to graft versus host disease or immune reconstitution and was responsive to intravenous methylprednisolone and cyclophosphamide.""?",False, -14891106,Methylprednisolone affects kidney disorder,457,"We investigated the effects of YM264, WEB2086, methylprednisolone and ticlopidine on puromycin-induced nephropathy in the rat.","Is the triple ""Methylprednisolone affects kidney disorder"" supported by the sentence: ""We investigated the effects of YM264, WEB2086, methylprednisolone and ticlopidine on puromycin-induced nephropathy in the rat.""?",False, -11819955,Methylprednisolone affects spinal cord injury,458,"The study strongly suggests that methylprednisolone has significant beneficial effects in human spinal cord injury, that these effects occur only when the drug is given within 8 hr, and that it helps even in patients with severe spinal cord injuries.","Is the triple ""Methylprednisolone affects spinal cord injury"" supported by the sentence: ""The study strongly suggests that methylprednisolone has significant beneficial effects in human spinal cord injury, that these effects occur only when the drug is given within 8 hr, and that it helps even in patients with severe spinal cord injuries.""?",False, -10845505,Methylprednisolone affects Pain,459,"Comparison of the effects of 2 doses of methylprednisolone on pain, swelling, and trismus after third molar surgery.","Is the triple ""Methylprednisolone affects Pain"" supported by the sentence: ""Comparison of the effects of 2 doses of methylprednisolone on pain, swelling, and trismus after third molar surgery.""?",False, -10048898,Methylprednisolone affects ulcerative colitis,460,Steatohepatitis during methylprednisolone therapy for ulcerative colitis exacerbation.,"Is the triple ""Methylprednisolone affects ulcerative colitis"" supported by the sentence: ""Steatohepatitis during methylprednisolone therapy for ulcerative colitis exacerbation.""?",False, -9646753,Methylprednisolone affects multiple sclerosis,461,These results suggest that increasing the uric acid concentration may represent one of the possible mechanisms of action of methylprednisolone in multiple sclerosis.,"Is the triple ""Methylprednisolone affects multiple sclerosis"" supported by the sentence: ""These results suggest that increasing the uric acid concentration may represent one of the possible mechanisms of action of methylprednisolone in multiple sclerosis.""?",False, -9346353,Methylprednisolone affects chronic obstructive pulmonary disease,462,"OBJECTIVE: Compare the therapeutic efficacy of an oral/metered-dose inhaler (oral/MDI) regimen to an intravenous/nebulizer (I.V./neb) regimen of methylprednisolone, cefuroxime, and inhaled albuterol and ipratropium bromide in patients hospitalized for exacerbations of chronic obstructive pulmonary disease (COPD).","Is the triple ""Methylprednisolone affects chronic obstructive pulmonary disease"" supported by the sentence: ""OBJECTIVE: Compare the therapeutic efficacy of an oral/metered-dose inhaler (oral/MDI) regimen to an intravenous/nebulizer (I.V./neb) regimen of methylprednisolone, cefuroxime, and inhaled albuterol and ipratropium bromide in patients hospitalized for exacerbations of chronic obstructive pulmonary disease (COPD).""?",False, -9107378,Methylprednisolone affects Edema,463,"Similar to the CRPS clinical response to glucocorticoids, we now demonstrate that chronic hindpaw edema in the sciatic transection CRPS model is reversed by a continuous infusion of MP (3 mg/kg/day over 21 days), and this anti-edematous effect persists for at least 1 week after discontinuing MP.","Is the triple ""Methylprednisolone affects Edema"" supported by the sentence: ""Similar to the CRPS clinical response to glucocorticoids, we now demonstrate that chronic hindpaw edema in the sciatic transection CRPS model is reversed by a continuous infusion of MP (3 mg/kg/day over 21 days), and this anti-edematous effect persists for at least 1 week after discontinuing MP.""?",False, -8596544,Methylprednisolone affects asthma,464,STUDY OBJECTIVES: To assess whether IV methylprednisolone exerts a specific early effect on dyspnea in patients with an exacerbation of asthma.,"Is the triple ""Methylprednisolone affects asthma"" supported by the sentence: ""STUDY OBJECTIVES: To assess whether IV methylprednisolone exerts a specific early effect on dyspnea in patients with an exacerbation of asthma.""?",False, -8330909,Methylprednisolone affects systemic lupus erythematosus,465,REVIEWER'S CONCLUSIONS: Cyclophosphamide regimen treatment is a form of care in neuropsychiatric involvement in systemic lupus erythematosus with no evidence to prove better effectiveness and safety when compared with methylprednisolone.,"Is the triple ""Methylprednisolone affects systemic lupus erythematosus"" supported by the sentence: ""REVIEWER'S CONCLUSIONS: Cyclophosphamide regimen treatment is a form of care in neuropsychiatric involvement in systemic lupus erythematosus with no evidence to prove better effectiveness and safety when compared with methylprednisolone.""?",False, -19744632,Methylprednisolone disrupts Edema,466,"RESULTS: Both methylprednisolone and dexamethasone significantly reduced swelling and trismus (P < .05, Kruskal-Wallis test), whereas the methylprednisolone group had significantly less pain (P < .05, Kruskal-Wallis test) and consumed a lower amount of analgesics (P < .05, chi2 test) during the early postoperative days.","Is the triple ""Methylprednisolone disrupts Edema"" supported by the sentence: ""RESULTS: Both methylprednisolone and dexamethasone significantly reduced swelling and trismus (P < .05, Kruskal-Wallis test), whereas the methylprednisolone group had significantly less pain (P < .05, Kruskal-Wallis test) and consumed a lower amount of analgesics (P < .05, chi2 test) during the early postoperative days.""?",False, -18407557,Methylprednisolone disrupts thrombocytopenia,467,Methylprednisolone only inhibited granulocytopenia and thrombocytopenia when zymosan-activated serum or fibrinogen-depleted plasma were infused.,"Is the triple ""Methylprednisolone disrupts thrombocytopenia"" supported by the sentence: ""Methylprednisolone only inhibited granulocytopenia and thrombocytopenia when zymosan-activated serum or fibrinogen-depleted plasma were infused.""?",False, -11106658,Methylprednisolone disrupts Pain,468,"In addition, we detected that sufentanil provided prolonged pain relief up to 24 h when compared with control, whereas when we combined sufentanil plus methylprednisolone, we found that it further reduced pain and use of analgesics when compared with sufentanil.","Is the triple ""Methylprednisolone disrupts Pain"" supported by the sentence: ""In addition, we detected that sufentanil provided prolonged pain relief up to 24 h when compared with control, whereas when we combined sufentanil plus methylprednisolone, we found that it further reduced pain and use of analgesics when compared with sufentanil.""?",False, -8640603,Methylprednisolone disrupts Inflammation,469,These findings demonstrate that MP may suppress post-traumatic inflammatory reaction by inhibiting both the AP-1 and NF-kappaB transcription cascades via a GR mechanism.,"Is the triple ""Methylprednisolone disrupts Inflammation"" supported by the sentence: ""These findings demonstrate that MP may suppress post-traumatic inflammatory reaction by inhibiting both the AP-1 and NF-kappaB transcription cascades via a GR mechanism.""?",False, -23934495,Methylprednisolone prevents Cognitive impairment,470,"This study assessed the effectiveness of a ganciclovir, methylprednisolone, and immunoglobulin combination (TAGMIC) therapy in decreasing cognitive impairment and mortality among patients with Japanese encephalitis.","Is the triple ""Methylprednisolone prevents Cognitive impairment"" supported by the sentence: ""This study assessed the effectiveness of a ganciclovir, methylprednisolone, and immunoglobulin combination (TAGMIC) therapy in decreasing cognitive impairment and mortality among patients with Japanese encephalitis.""?",False, -20014108,Methylprednisolone prevents rheumatoid arthritis,471,"From indirect comparisons, most interventions showed decreased risk of developing RA compared to placebo at 12 months, reaching statistical significance for methotrexate (OR 0.16 [95% CI 0.08, 0.33]) and intramuscular methylprednisolone (OR 0.72 [95% CI 0.53, 0.99]).","Is the triple ""Methylprednisolone prevents rheumatoid arthritis"" supported by the sentence: ""From indirect comparisons, most interventions showed decreased risk of developing RA compared to placebo at 12 months, reaching statistical significance for methotrexate (OR 0.16 [95% CI 0.08, 0.33]) and intramuscular methylprednisolone (OR 0.72 [95% CI 0.53, 0.99]).""?",False, -18266414,Methylprednisolone prevents Abdominal pain,472,Treatment with a pulse of methylprednisolone reduced both abdominal pain and lesion size.,"Is the triple ""Methylprednisolone prevents Abdominal pain"" supported by the sentence: ""Treatment with a pulse of methylprednisolone reduced both abdominal pain and lesion size.""?",False, -14967074,Methylprednisolone prevents asthma,473,Methylprednisolone prevents propranolol-induced airway hyperreactivity in the Basenji-greyhound dog.,"Is the triple ""Methylprednisolone prevents asthma"" supported by the sentence: ""Methylprednisolone prevents propranolol-induced airway hyperreactivity in the Basenji-greyhound dog.""?",False, -9744990,Methylprednisolone prevents ovarian hyperstimulation syndrome,474,Administration of methylprednisolone to prevent severe ovarian hyperstimulation syndrome in patients undergoing in vitro fertilization.,"Is the triple ""Methylprednisolone prevents ovarian hyperstimulation syndrome"" supported by the sentence: ""Administration of methylprednisolone to prevent severe ovarian hyperstimulation syndrome in patients undergoing in vitro fertilization.""?",False, -8345063,Methylprednisolone prevents Pain,475,"Combined methylprednisolone, bupivacaine and morphine reduced pain, joint swelling, time of immobilization, duration of sick leave and return to sports after the arthroscopic procedure.","Is the triple ""Methylprednisolone prevents Pain"" supported by the sentence: ""Combined methylprednisolone, bupivacaine and morphine reduced pain, joint swelling, time of immobilization, duration of sick leave and return to sports after the arthroscopic procedure.""?",False, -8291272,Methylprednisolone prevents graft versus host disease,476,Forty-eight patients who underwent bone marrow transplantation (BMT) from serologically HLA-matched unrelated donors received tacrolimus (FK506) alone or with methotrexate (MTX) and/or methylprednisolone (mPSL) to prevent graft-versus-host disease (GVHD).,"Is the triple ""Methylprednisolone prevents graft versus host disease"" supported by the sentence: ""Forty-eight patients who underwent bone marrow transplantation (BMT) from serologically HLA-matched unrelated donors received tacrolimus (FK506) alone or with methotrexate (MTX) and/or methylprednisolone (mPSL) to prevent graft-versus-host disease (GVHD).""?",False, -7980138,Methylprednisolone prevents spinal cord injury,477,"Thus, calpeptin and methylprednisolone are found to be neuroprotective in SCI.","Is the triple ""Methylprednisolone prevents spinal cord injury"" supported by the sentence: ""Thus, calpeptin and methylprednisolone are found to be neuroprotective in SCI.""?",False, -7414405,Methylprednisolone prevents Edema,478,"Methylprednisolone prevents the development of autotomy and neuropathic edema in rats, but has no effect on nociceptive thresholds.","Is the triple ""Methylprednisolone prevents Edema"" supported by the sentence: ""Methylprednisolone prevents the development of autotomy and neuropathic edema in rats, but has no effect on nociceptive thresholds.""?",False, -18106042,Methylprednisolone predisposes pneumonia,479,Chronically impaired renal function and the use of methylprednisolone may be the risk factors for SP.,"Is the triple ""Methylprednisolone predisposes pneumonia"" supported by the sentence: ""Chronically impaired renal function and the use of methylprednisolone may be the risk factors for SP.""?",False, -9645180,Methylprednisolone predisposes Inflammation,480,"Because a common therapy for acute spinal cord injury is the use of an antiinflammatory synthetic glucocorticoid (methylprednisolone), we sought to determine mechanisms contributing to inflammation shortly after acute injury.","Is the triple ""Methylprednisolone predisposes Inflammation"" supported by the sentence: ""Because a common therapy for acute spinal cord injury is the use of an antiinflammatory synthetic glucocorticoid (methylprednisolone), we sought to determine mechanisms contributing to inflammation shortly after acute injury.""?",False, -12905337,Cefotaxime related to Sepsis,481,"Combined treatments of rG-CSF with cefotaxime, cefazolin, fosfomycin, gentamicin or amphotericin B were evaluated in systemic infections with Pseudomonas aeruginosa, Escherichia coli, Serratia marcescens, Staphylococcus aureus and Candida albicans in leucopenic mice induced by pretreatment with cyclophosphamide.","Is the triple ""Cefotaxime related to Sepsis"" supported by the sentence: ""Combined treatments of rG-CSF with cefotaxime, cefazolin, fosfomycin, gentamicin or amphotericin B were evaluated in systemic infections with Pseudomonas aeruginosa, Escherichia coli, Serratia marcescens, Staphylococcus aureus and Candida albicans in leucopenic mice induced by pretreatment with cyclophosphamide.""?",False, -24475300,Cefotaxime affects bacterial infectious disease,482,"One such marker, CTX-M-15, expressed by Enterobacteriaceae produces beta-lactamases, which hydrolyze the cephalosporin group of antibiotics, such as cefotaxime, used in the treatment of both Gram-positive and negative bacterial infections.","Is the triple ""Cefotaxime affects bacterial infectious disease"" supported by the sentence: ""One such marker, CTX-M-15, expressed by Enterobacteriaceae produces beta-lactamases, which hydrolyze the cephalosporin group of antibiotics, such as cefotaxime, used in the treatment of both Gram-positive and negative bacterial infections.""?",False, -23922029,Cefotaxime affects Sepsis,483,"CONS, Staphylococcus aureus, Enterococci, Escherichia coli, Klebsiella and Enterobacter represented 91.9% of LOS episodes and were susceptible to vancomycin and cefotaxime (96.1%), vancomycin and gentamicin (97.0%) and cloxacillin and gentamicin (38.1%).","Is the triple ""Cefotaxime affects Sepsis"" supported by the sentence: ""CONS, Staphylococcus aureus, Enterococci, Escherichia coli, Klebsiella and Enterobacter represented 91.9% of LOS episodes and were susceptible to vancomycin and cefotaxime (96.1%), vancomycin and gentamicin (97.0%) and cloxacillin and gentamicin (38.1%).""?",False, -18672205,Cefotaxime affects peritonitis,484,"The protective effect of cefotaxime, aztreonam and gentamicin in peritonitis induced by E. coli alone or combined with B. fragilis was evaluated by analysing mortality at 24 and 48 h after bacterial inoculation and treating the animals with two doses of each antibiotic.","Is the triple ""Cefotaxime affects peritonitis"" supported by the sentence: ""The protective effect of cefotaxime, aztreonam and gentamicin in peritonitis induced by E. coli alone or combined with B. fragilis was evaluated by analysing mortality at 24 and 48 h after bacterial inoculation and treating the animals with two doses of each antibiotic.""?",False, -15853591,Cefotaxime prevents Sepsis,485,"HR 810 had more potent protective effect than ceftazidime (CAZ), cefoperazone (CPZ), and cefotaxime (CTX) on systemic infections induced by Escherichia coli Ec-31, Staphylococcus aureus SMITH, and Serratia marcescens Sm-6 in mice.","Is the triple ""Cefotaxime prevents Sepsis"" supported by the sentence: ""HR 810 had more potent protective effect than ceftazidime (CAZ), cefoperazone (CPZ), and cefotaxime (CTX) on systemic infections induced by Escherichia coli Ec-31, Staphylococcus aureus SMITH, and Serratia marcescens Sm-6 in mice.""?",False, -19081412,Ceftriaxone prevents bacterial infectious disease,486,"1,480 patients, undergoing elective orthopedic and traumatic surgery, received intragluteal injections of ceftriaxone (Rocephin) to prevent bacterial infections.","Is the triple ""Ceftriaxone prevents bacterial infectious disease"" supported by the sentence: ""1,480 patients, undergoing elective orthopedic and traumatic surgery, received intragluteal injections of ceftriaxone (Rocephin) to prevent bacterial infections.""?",False, -25827448,Gefarnate related to gastric ulcer,487,Proceedings: A double blind trial of carbenoxolone and geranyl farnesylacetate in gastric ulcer.,"Is the triple ""Gefarnate related to gastric ulcer"" supported by the sentence: ""Proceedings: A double blind trial of carbenoxolone and geranyl farnesylacetate in gastric ulcer.""?",False, -24296137,Gefarnate related to duodenal ulcer,488,A controlled double-blind study was performed in 17 institutes using gefarnate as a control drug in order to investigate the therapeutic effect and safety of pirenzepine dihydrochloride (LS 519) in duodenal ulcer.,"Is the triple ""Gefarnate related to duodenal ulcer"" supported by the sentence: ""A controlled double-blind study was performed in 17 institutes using gefarnate as a control drug in order to investigate the therapeutic effect and safety of pirenzepine dihydrochloride (LS 519) in duodenal ulcer.""?",False, -25993651,Gefarnate disrupts gastric ulcer,489,Gefarnate at 300 mg/kg (p.o.) significantly inhibited phenylbutazone-induced gastric ulcers in rats but had no effect on other ulcer models.,"Is the triple ""Gefarnate disrupts gastric ulcer"" supported by the sentence: ""Gefarnate at 300 mg/kg (p.o.) significantly inhibited phenylbutazone-induced gastric ulcers in rats but had no effect on other ulcer models.""?",False, -17758516,Neobiotic related to Inflammation,490,We tested streptomycin (ST) and neomycin (NEO) as analgesic agents applied in situ in rat paw inflammation caused by formalin or carrageenan administration.,"Is the triple ""Neobiotic related to Inflammation"" supported by the sentence: ""We tested streptomycin (ST) and neomycin (NEO) as analgesic agents applied in situ in rat paw inflammation caused by formalin or carrageenan administration.""?",False, -10690423,Neobiotic related to burn,491,[ON THE ACTION OF A NEOMYCIN AND THIOPENICOL PREPARATION IN EXPERIMENTAL BURNS].,"Is the triple ""Neobiotic related to burn"" supported by the sentence: ""[ON THE ACTION OF A NEOMYCIN AND THIOPENICOL PREPARATION IN EXPERIMENTAL BURNS].""?",False, -20263460,Neobiotic affects neoplasm,492,"Therefore, we investigated the effect of long-term exposure of an antibiotic cocktail composed of Vancomycin, Neomycin, and Streptomycin, on tumor development and progression in the ApcMin/+ mouse, an established genetic model for familial adenomatous polyposis.","Is the triple ""Neobiotic affects neoplasm"" supported by the sentence: ""Therefore, we investigated the effect of long-term exposure of an antibiotic cocktail composed of Vancomycin, Neomycin, and Streptomycin, on tumor development and progression in the ApcMin/+ mouse, an established genetic model for familial adenomatous polyposis.""?",False, -19744068,Neobiotic affects Inflammation,493,Ultrahigh doses of gentamicin and clinically relevant doses of neomycin affect inflammation and angiogenesis in in vivo and in vitro models.,"Is the triple ""Neobiotic affects Inflammation"" supported by the sentence: ""Ultrahigh doses of gentamicin and clinically relevant doses of neomycin affect inflammation and angiogenesis in in vivo and in vitro models.""?",False, -24669492,Neobiotic disrupts bacterial infectious disease,494,"Biodegradable polyaspartamide (PASPAM) was grafted with several functional groups to implement diverse roles-octadecylamine (C 18 ) for nano-aggregate formation, dopamine (DOPA) for adhesive function, neomycin (NEO) for inhibition of bacterial infection.","Is the triple ""Neobiotic disrupts bacterial infectious disease"" supported by the sentence: ""Biodegradable polyaspartamide (PASPAM) was grafted with several functional groups to implement diverse roles-octadecylamine (C 18 ) for nano-aggregate formation, dopamine (DOPA) for adhesive function, neomycin (NEO) for inhibition of bacterial infection.""?",False, -17119153,Neobiotic disrupts neoplasm,495,Kaposi's sarcoma-associated herpesvirus-positive primary effusion lymphoma tumor formation in NOD/SCID mice is inhibited by neomycin and neamine blocking angiogenin's nuclear translocation.,"Is the triple ""Neobiotic disrupts neoplasm"" supported by the sentence: ""Kaposi's sarcoma-associated herpesvirus-positive primary effusion lymphoma tumor formation in NOD/SCID mice is inhibited by neomycin and neamine blocking angiogenin's nuclear translocation.""?",False, -26428369,Neobiotic prevents bacterial infectious disease,496,Neomycin and the combination of neomycin and bacitracin in the prevention of bacterial infection in surgery of the colon and/or rectum.,"Is the triple ""Neobiotic prevents bacterial infectious disease"" supported by the sentence: ""Neomycin and the combination of neomycin and bacitracin in the prevention of bacterial infection in surgery of the colon and/or rectum.""?",False, -25579460,BLINATUMOMAB related to Precursor B-Cell Lymphoblastic Leukemia-Lymphoma,497,Results of salvage therapy with mini-hyper-CVD and inotuzumab ozogamicin with or without blinatumomab in pre-B acute lymphoblastic leukemia.,"Is the triple ""BLINATUMOMAB related to Precursor B-Cell Lymphoblastic Leukemia-Lymphoma"" supported by the sentence: ""Results of salvage therapy with mini-hyper-CVD and inotuzumab ozogamicin with or without blinatumomab in pre-B acute lymphoblastic leukemia.""?",False, -22474123,BLINATUMOMAB related to hematopoietic and lymphoid system neoplasm,498,"The impressive clinical success of the continuously intravenously infused T cell-redirecting bispecific antibody (T-bsAb) blinatumomab (anti-CD19 x anti-CD3), and of engineered T cells expressing anti-CD19 chimeric antigen receptors (CAR-T cells) in hematological malignancies, has led to renewed interest in a novel cancer immunotherapy strategy that combines features of antibody- and cell-based therapies.","Is the triple ""BLINATUMOMAB related to hematopoietic and lymphoid system neoplasm"" supported by the sentence: ""The impressive clinical success of the continuously intravenously infused T cell-redirecting bispecific antibody (T-bsAb) blinatumomab (anti-CD19 x anti-CD3), and of engineered T cells expressing anti-CD19 chimeric antigen receptors (CAR-T cells) in hematological malignancies, has led to renewed interest in a novel cancer immunotherapy strategy that combines features of antibody- and cell-based therapies.""?",False, -21947892,BLINATUMOMAB related to acute lymphoblastic leukemia,499,Blinatumomab and inotuzumab ozogamycin represent promising alternatives to conventional chemotherapy in acute lymphoblastic leukaemia (ALL).,"Is the triple ""BLINATUMOMAB related to acute lymphoblastic leukemia"" supported by the sentence: ""Blinatumomab and inotuzumab ozogamycin represent promising alternatives to conventional chemotherapy in acute lymphoblastic leukaemia (ALL).""?",False, -27155094,Ciprofloxacin related to endophthalmitis,500,Efficacy of ciprofloxacin and dexamethasone in experimental pseudomonas endophthalmitis.,"Is the triple ""Ciprofloxacin related to endophthalmitis"" supported by the sentence: ""Efficacy of ciprofloxacin and dexamethasone in experimental pseudomonas endophthalmitis.""?",False, -16836665,Ciprofloxacin related to Crohn disease,501,CONCLUSIONS: Combination therapy of adalimumab and ciprofloxacin is more effective than adalimumab monotherapy to achieve fistula closure in CD.,"Is the triple ""Ciprofloxacin related to Crohn disease"" supported by the sentence: ""CONCLUSIONS: Combination therapy of adalimumab and ciprofloxacin is more effective than adalimumab monotherapy to achieve fistula closure in CD.""?",False, +Predicate ID,Triple,Sentence ID,Sentence,Question,Label,Reference +26452786,Fenbendazole causes helminthiasis,101,Evaluation of granulated fenbendazole (22.2%) against induced and naturally occurring helminth infections in cats.,"Is the triple ""Fenbendazole causes helminthiasis"" supported by the sentence: ""Evaluation of granulated fenbendazole (22.2%) against induced and naturally occurring helminth infections in cats.""?",False, +22762728,Fenbendazole prevents helminthiasis,102,Fenbendazole resistance in O. ostertagi was confirmed with a total treatment failure in reducing worm burden: efficacy of 0%.,"Is the triple ""Fenbendazole prevents helminthiasis"" supported by the sentence: ""Fenbendazole resistance in O. ostertagi was confirmed with a total treatment failure in reducing worm burden: efficacy of 0%.""?",False, +21848143,Albendazole causes helminthiasis,103,Symptoms of perianal itching and visualization of visible motile worms persisted for 6 months despite being treated with multiple courses of albendazole causing a lot of frustration and distress to the caregivers.,"Is the triple ""Albendazole causes helminthiasis"" supported by the sentence: ""Symptoms of perianal itching and visualization of visible motile worms persisted for 6 months despite being treated with multiple courses of albendazole causing a lot of frustration and distress to the caregivers.""?",False, +25735916,Albendazole affects trichuriasis,104,"Ovicidal effects of albendazole in human ascariasis, ancylostomiasis and trichuriasis.","Is the triple ""Albendazole affects trichuriasis"" supported by the sentence: ""Ovicidal effects of albendazole in human ascariasis, ancylostomiasis and trichuriasis.""?",False, +24685635,Albendazole affects filarial elephantiasis,105,"A combination of drugs Ivermectin, Diethylcarbamazine citrate and Albendazole is recommended by WHO to accelerate the Global Programme to Eliminate Lymphatic Filariasis (GPELF).","Is the triple ""Albendazole affects filarial elephantiasis"" supported by the sentence: ""A combination of drugs Ivermectin, Diethylcarbamazine citrate and Albendazole is recommended by WHO to accelerate the Global Programme to Eliminate Lymphatic Filariasis (GPELF).""?",False, +18452252,Albendazole affects toxocariasis,106,Effect of albendazole in experimental toxocariasis of mice.,"Is the triple ""Albendazole affects toxocariasis"" supported by the sentence: ""Effect of albendazole in experimental toxocariasis of mice.""?",False, +16658505,Albendazole affects malaria,107,"Given the low helminth prevalence in our children, the effect of albendazole on malaria is likely to be direct.","Is the triple ""Albendazole affects malaria"" supported by the sentence: ""Given the low helminth prevalence in our children, the effect of albendazole on malaria is likely to be direct.""?",False, +13946207,Albendazole affects helminthiasis,108,"Mass co-administration of ivermectin and albendazole by the LFEP had a significant effect on STH, which was further amplified by treatment with praziquantel and albendazole 4 months later.","Is the triple ""Albendazole affects helminthiasis"" supported by the sentence: ""Mass co-administration of ivermectin and albendazole by the LFEP had a significant effect on STH, which was further amplified by treatment with praziquantel and albendazole 4 months later.""?",False, +11239060,Albendazole affects filariasis,109,The effect of single dose ivermectin alone or in combination with albendazole on Wuchereria bancrofti infection in primary school children in Tanzania.,"Is the triple ""Albendazole affects filariasis"" supported by the sentence: ""The effect of single dose ivermectin alone or in combination with albendazole on Wuchereria bancrofti infection in primary school children in Tanzania.""?",False, +24729219,Albendazole disrupts helminthiasis,110,"Additionally, compared with albendazole, it resulted in a significant reduction in adult worm and total larval counts; moreover, it caused a decrease in the number of larvae deposited in muscles, with a highly significant decrease in the inflammatory cell infiltrate around the larvae and a considerable decrease in the expression of the angiogenic marker vascular endothelial growth factor in muscles.","Is the triple ""Albendazole disrupts helminthiasis"" supported by the sentence: ""Additionally, compared with albendazole, it resulted in a significant reduction in adult worm and total larval counts; moreover, it caused a decrease in the number of larvae deposited in muscles, with a highly significant decrease in the inflammatory cell infiltrate around the larvae and a considerable decrease in the expression of the angiogenic marker vascular endothelial growth factor in muscles.""?",False, +16658503,Albendazole disrupts malaria,111,"Quarterly albendazole during childhood was associated with reduced incidence of clinical malaria (HR 0.85 (95% CI 0.73-0.98), p = 0.03).","Is the triple ""Albendazole disrupts malaria"" supported by the sentence: ""Quarterly albendazole during childhood was associated with reduced incidence of clinical malaria (HR 0.85 (95% CI 0.73-0.98), p = 0.03).""?",False, +13637338,Albendazole disrupts Hookworm Infections,112,CONCLUSIONS: Mebendazole and albendazole showed reduced efficacy against Ascaris lumbricoides and hookworm infections at the recommended doses.,"Is the triple ""Albendazole disrupts Hookworm Infections"" supported by the sentence: ""CONCLUSIONS: Mebendazole and albendazole showed reduced efficacy against Ascaris lumbricoides and hookworm infections at the recommended doses.""?",False, +15248433,Albendazole prevents filariasis,113,Evaluation of effectiveness of diethylcarbamazine/albendazole combination in reduction of Wuchereria bancrofti infection using multiple infection parameters.,"Is the triple ""Albendazole prevents filariasis"" supported by the sentence: ""Evaluation of effectiveness of diethylcarbamazine/albendazole combination in reduction of Wuchereria bancrofti infection using multiple infection parameters.""?",False, +13732336,Albendazole prevents helminthiasis,114,"Our evaluation suggests that although additional studies are needed to determine optimal treatment regimens for intestinal parasites, especially among young children and pregnant women, a five-day course of pre-departure albendazole was effective in reducing helminthic infection in treated refugees.","Is the triple ""Albendazole prevents helminthiasis"" supported by the sentence: ""Our evaluation suggests that although additional studies are needed to determine optimal treatment regimens for intestinal parasites, especially among young children and pregnant women, a five-day course of pre-departure albendazole was effective in reducing helminthic infection in treated refugees.""?",False, +15316470,Ibuprofen subclass of 2-Hydroxyibuprofen,115,"The purpose of this study was the development and validation of an LC-MS-MS method for simultaneous analysis of ibuprofen (IBP), 2-hydroxyibuprofen (2-OH-IBP) enantiomers, and carboxyibuprofen (COOH-IBP) stereoisomers in fungi culture medium, to investigate the ability of some endophytic fungi to biotransform the chiral drug IBP into its metabolites.","Is the triple ""Ibuprofen subclass of 2-Hydroxyibuprofen"" supported by the sentence: ""The purpose of this study was the development and validation of an LC-MS-MS method for simultaneous analysis of ibuprofen (IBP), 2-hydroxyibuprofen (2-OH-IBP) enantiomers, and carboxyibuprofen (COOH-IBP) stereoisomers in fungi culture medium, to investigate the ability of some endophytic fungi to biotransform the chiral drug IBP into its metabolites.""?",False, +16265626,Ibuprofen related to Arthralgia,116,"AIMS: To carry out a randomized clinical trial to compare the effect of palmitoylethanolamide (PEA) versus ibuprofen, a nonsteroidal anti-inflammatory drug (NSAID), for pain relief in temporomandibular joint (TMJ) osteoarthritis or arthralgia.","Is the triple ""Ibuprofen related to Arthralgia"" supported by the sentence: ""AIMS: To carry out a randomized clinical trial to compare the effect of palmitoylethanolamide (PEA) versus ibuprofen, a nonsteroidal anti-inflammatory drug (NSAID), for pain relief in temporomandibular joint (TMJ) osteoarthritis or arthralgia.""?",False, +14582794,Ibuprofen related to Pain,117,"We investigated the analgesic efficacy of single doses of ibuprofen, tramadol and pregabalin in menthol-evoked cold pain in a randomized, placebo-controlled four-way cross-over study in 20 healthy volunteers.","Is the triple ""Ibuprofen related to Pain"" supported by the sentence: ""We investigated the analgesic efficacy of single doses of ibuprofen, tramadol and pregabalin in menthol-evoked cold pain in a randomized, placebo-controlled four-way cross-over study in 20 healthy volunteers.""?",False, +11440746,Ibuprofen related to Toothache,118,Double blind study on emorfazone and ibuprofen in dental pain and inflammation.,"Is the triple ""Ibuprofen related to Toothache"" supported by the sentence: ""Double blind study on emorfazone and ibuprofen in dental pain and inflammation.""?",False, +9106384,Ibuprofen related to osteoarthritis,119,Glucosamine sulfate compared to ibuprofen in osteoarthritis of the knee.,"Is the triple ""Ibuprofen related to osteoarthritis"" supported by the sentence: ""Glucosamine sulfate compared to ibuprofen in osteoarthritis of the knee.""?",False, +8106985,Ibuprofen related to burn,120,INTRODUCTION: The anti-inflammatory and anticoagulant effects of ibuprofen and heparin may enhance skin perfusion in cutaneous scald burns.,"Is the triple ""Ibuprofen related to burn"" supported by the sentence: ""INTRODUCTION: The anti-inflammatory and anticoagulant effects of ibuprofen and heparin may enhance skin perfusion in cutaneous scald burns.""?",False, +13726345,Ibuprofen causes patent ductus arteriosus,121,"CONCLUSIONS: Ibuprofen-induced patent ductus arteriosus closure improved pulmonary mechanics, decreased total lung water, increased epithelial sodium channel expression, and decreased the detrimental effects of preterm birth on alveolarization.","Is the triple ""Ibuprofen causes patent ductus arteriosus"" supported by the sentence: ""CONCLUSIONS: Ibuprofen-induced patent ductus arteriosus closure improved pulmonary mechanics, decreased total lung water, increased epithelial sodium channel expression, and decreased the detrimental effects of preterm birth on alveolarization.""?",False, +13653982,Ibuprofen causes Alzheimer disease,122,Protein profile in neuroblastoma cells incubated with S- and R-enantiomers of ibuprofen by iTRAQ-coupled 2-D LC-MS/MS analysis: possible action of induced proteins on Alzheimer's disease.,"Is the triple ""Ibuprofen causes Alzheimer disease"" supported by the sentence: ""Protein profile in neuroblastoma cells incubated with S- and R-enantiomers of ibuprofen by iTRAQ-coupled 2-D LC-MS/MS analysis: possible action of induced proteins on Alzheimer's disease.""?",False, +13133316,Ibuprofen causes peptic ulcer disease,123,Protective effect of glucosamine against ibuprofen-induced peptic ulcer in rats.,"Is the triple ""Ibuprofen causes peptic ulcer disease"" supported by the sentence: ""Protective effect of glucosamine against ibuprofen-induced peptic ulcer in rats.""?",False, +12641386,Ibuprofen causes Fever,124,Ibuprofen-induced fever in Sjogren's syndrome.,"Is the triple ""Ibuprofen causes Fever"" supported by the sentence: ""Ibuprofen-induced fever in Sjogren's syndrome.""?",False, +12482174,Ibuprofen causes pancreatitis,125,There have been no prior definite cases reported of ibuprofen-induced pancreatitis.,"Is the triple ""Ibuprofen causes pancreatitis"" supported by the sentence: ""There have been no prior definite cases reported of ibuprofen-induced pancreatitis.""?",False, +12438812,Ibuprofen causes Toothache,126,"RESULTS: None of the studies established any of the COX-2 inhibitors as clearly better than ibuprofen, the current gold standard for the treatment of surgically induced dental pain.","Is the triple ""Ibuprofen causes Toothache"" supported by the sentence: ""RESULTS: None of the studies established any of the COX-2 inhibitors as clearly better than ibuprofen, the current gold standard for the treatment of surgically induced dental pain.""?",False, +12079834,Ibuprofen causes adult acute respiratory distress syndrome,127,Noncardiogenic pulmonary edema due to ibuprofen.,"Is the triple ""Ibuprofen causes adult acute respiratory distress syndrome"" supported by the sentence: ""Noncardiogenic pulmonary edema due to ibuprofen.""?",False, +11157616,Ibuprofen causes Pain,128,"In a double-blind cross-over study on 22 healthy subjects the analgesic efficacies of the antipyretic analgesic drugs ibuprofen, dipyrone and paracetamol were tested against placebo using a model of experimentally induced pain.","Is the triple ""Ibuprofen causes Pain"" supported by the sentence: ""In a double-blind cross-over study on 22 healthy subjects the analgesic efficacies of the antipyretic analgesic drugs ibuprofen, dipyrone and paracetamol were tested against placebo using a model of experimentally induced pain.""?",False, +10429873,Ibuprofen causes Hemorrhage,129,Unaltered ibuprofen-induced faecal blood loss upon coadministration of moclobemide.,"Is the triple ""Ibuprofen causes Hemorrhage"" supported by the sentence: ""Unaltered ibuprofen-induced faecal blood loss upon coadministration of moclobemide.""?",False, +9800201,Ibuprofen causes arthritic joint disease,130,The C5a antagonist (1 or 3 mg/kg/day) and/or ibuprofen (30 mg/kg/day) were administered orally on a daily basis either before or after arthritis induction.,"Is the triple ""Ibuprofen causes arthritic joint disease"" supported by the sentence: ""The C5a antagonist (1 or 3 mg/kg/day) and/or ibuprofen (30 mg/kg/day) were administered orally on a daily basis either before or after arthritis induction.""?",False, +8163776,Ibuprofen causes injury,131,RESULTS: Ketoprofen 50 mg t.d.s. suppressed prostaglandin synthesis to a significantly greater extent than ibuprofen and caused significantly more gastroduodenal injury.,"Is the triple ""Ibuprofen causes injury"" supported by the sentence: ""RESULTS: Ketoprofen 50 mg t.d.s. suppressed prostaglandin synthesis to a significantly greater extent than ibuprofen and caused significantly more gastroduodenal injury.""?",False, +26701175,Ibuprofen affects rheumatoid arthritis,132,The duration of action of sustained-release ibuprofen ('Brufen Retard') was investigated in a 14-day double-blind study involving 14 osteoarthritis and 10 rheumatoid arthritis patients.,"Is the triple ""Ibuprofen affects rheumatoid arthritis"" supported by the sentence: ""The duration of action of sustained-release ibuprofen ('Brufen Retard') was investigated in a 14-day double-blind study involving 14 osteoarthritis and 10 rheumatoid arthritis patients.""?",False, +24384432,Ibuprofen affects migraine disorder,133,This study attempts to investigate the effect of ibuprofen on reducing eye pain and migraine headaches caused by trochleitis.,"Is the triple ""Ibuprofen affects migraine disorder"" supported by the sentence: ""This study attempts to investigate the effect of ibuprofen on reducing eye pain and migraine headaches caused by trochleitis.""?",False, +23500890,Ibuprofen affects adult acute respiratory distress syndrome,134,"Ibuprofen suppresses the production of various pro-inflammatory cytokines that are implicated in the ""cytokine storm"" and subsequent ARDS in COVID-19 disease.","Is the triple ""Ibuprofen affects adult acute respiratory distress syndrome"" supported by the sentence: ""Ibuprofen suppresses the production of various pro-inflammatory cytokines that are implicated in the ""cytokine storm"" and subsequent ARDS in COVID-19 disease.""?",False, +21214366,Ibuprofen affects bronchopulmonary dysplasia,135,"After adjusting for covariates, the risk of BPD was associated independently with ibuprofen exposure (odds ratios (OR) 2.296, 95% confidence interval (CI): 1.166-4.522, p = 0.016).","Is the triple ""Ibuprofen affects bronchopulmonary dysplasia"" supported by the sentence: ""After adjusting for covariates, the risk of BPD was associated independently with ibuprofen exposure (odds ratios (OR) 2.296, 95% confidence interval (CI): 1.166-4.522, p = 0.016).""?",False, +20886939,Ibuprofen affects Cognitive impairment,136,The opposite effect of ibuprofen on ethanol-induced cognitive impairment as measured by two lateralized functions is consistent with the reports in tissue and animal models that central nervous system effects of ethanol may be mediated at least in part by prostaglandins.,"Is the triple ""Ibuprofen affects Cognitive impairment"" supported by the sentence: ""The opposite effect of ibuprofen on ethanol-induced cognitive impairment as measured by two lateralized functions is consistent with the reports in tissue and animal models that central nervous system effects of ethanol may be mediated at least in part by prostaglandins.""?",False, +18977843,Ibuprofen affects Headache,137,"On post-partum day five, she began complaining of headaches, initially responsive to ibuprofen but eventually worsened with no relief.","Is the triple ""Ibuprofen affects Headache"" supported by the sentence: ""On post-partum day five, she began complaining of headaches, initially responsive to ibuprofen but eventually worsened with no relief.""?",False, +15746938,Ibuprofen affects injury,138,"Because ibuprofen protects from septic lung injury, we studied the effect of ibuprofen in oxidant lung injury from phosgene.","Is the triple ""Ibuprofen affects injury"" supported by the sentence: ""Because ibuprofen protects from septic lung injury, we studied the effect of ibuprofen in oxidant lung injury from phosgene.""?",False, +13826486,Ibuprofen affects osteoarthritis,139,The efficacy and tolerance of ibuprofen retard at a dose of 2 x 800 mg daily was investigated in an open multicenter study over a period of 3 weeks on 7931 out-patients with activated degenerative joint disease and/or extraarticular rheumatic symptoms.,"Is the triple ""Ibuprofen affects osteoarthritis"" supported by the sentence: ""The efficacy and tolerance of ibuprofen retard at a dose of 2 x 800 mg daily was investigated in an open multicenter study over a period of 3 weeks on 7931 out-patients with activated degenerative joint disease and/or extraarticular rheumatic symptoms.""?",False, +13584223,Ibuprofen affects Cognitive impairment,140,"Overall, we found no relation between regular aspirin use and cognitive decline, but long-term use of ibuprofen may be related to decreased rates of cognitive decline in older persons.","Is the triple ""Ibuprofen affects Cognitive impairment"" supported by the sentence: ""Overall, we found no relation between regular aspirin use and cognitive decline, but long-term use of ibuprofen may be related to decreased rates of cognitive decline in older persons.""?",False, +12659717,Ibuprofen affects Fever,141,"Subdiaphragmatic vagotomy or 7-nitroindazole reduced, icatibant, DALBK, IL-1ra, aminoguanidine and dipyrone abolished, while ibuprofen and celecoxib failed to affect Tsv-induced fever.","Is the triple ""Ibuprofen affects Fever"" supported by the sentence: ""Subdiaphragmatic vagotomy or 7-nitroindazole reduced, icatibant, DALBK, IL-1ra, aminoguanidine and dipyrone abolished, while ibuprofen and celecoxib failed to affect Tsv-induced fever.""?",False, +11207850,Ibuprofen affects peptic ulcer disease,142,Reduced incidence of gastroduodenal ulcers associated with lumiracoxib compared with ibuprofen in patients with rheumatoid arthritis.,"Is the triple ""Ibuprofen affects peptic ulcer disease"" supported by the sentence: ""Reduced incidence of gastroduodenal ulcers associated with lumiracoxib compared with ibuprofen in patients with rheumatoid arthritis.""?",False, +11159990,Ibuprofen affects Hemorrhage,143,It was also investigated whether the use of ibuprofen or paracetamol would influence the amount of surgical bleeding.,"Is the triple ""Ibuprofen affects Hemorrhage"" supported by the sentence: ""It was also investigated whether the use of ibuprofen or paracetamol would influence the amount of surgical bleeding.""?",False, +10170540,Ibuprofen affects patent ductus arteriosus,144,"In a randomised, placebo-controlled, double-blind trial of prophylaxis with ibuprofen, the rate of patent ductus arteriosus associated with ibuprofen was 19% compared with 42% with placebo.","Is the triple ""Ibuprofen affects patent ductus arteriosus"" supported by the sentence: ""In a randomised, placebo-controlled, double-blind trial of prophylaxis with ibuprofen, the rate of patent ductus arteriosus associated with ibuprofen was 19% compared with 42% with placebo.""?",False, +10026104,Ibuprofen affects Myalgia,145,"The purpose of this study was to examine the effects of ibuprofen on delayed onset muscle soreness (DOMS), indirect markers of muscle damage and muscular performance.","Is the triple ""Ibuprofen affects Myalgia"" supported by the sentence: ""The purpose of this study was to examine the effects of ibuprofen on delayed onset muscle soreness (DOMS), indirect markers of muscle damage and muscular performance.""?",False, +9889792,Ibuprofen affects Hemorrhage,146,CONCLUSIONS: Pretreatment with ibuprofen before elective total hip surgery increases the perioperative blood loss significantly.,"Is the triple ""Ibuprofen affects Hemorrhage"" supported by the sentence: ""CONCLUSIONS: Pretreatment with ibuprofen before elective total hip surgery increases the perioperative blood loss significantly.""?",False, +8819538,Ibuprofen affects osteoarthritis,147,"The data suggest that nimesulide and ibuprofen, in addition to their anti-inflammatory and analgesic benefits, may also have a protective effect in osteoarthritis through the inhibition of apoptosis in chondrocytes.","Is the triple ""Ibuprofen affects osteoarthritis"" supported by the sentence: ""The data suggest that nimesulide and ibuprofen, in addition to their anti-inflammatory and analgesic benefits, may also have a protective effect in osteoarthritis through the inhibition of apoptosis in chondrocytes.""?",False, +8421263,Ibuprofen affects Fever,148,Pretreatment with ibuprofen blocked the fever induced by RANTES.,"Is the triple ""Ibuprofen affects Fever"" supported by the sentence: ""Pretreatment with ibuprofen blocked the fever induced by RANTES.""?",False, +27630106,Ibuprofen disrupts Acute Pain,149,This study evaluated whether administration of the pharmacologically active S(+)-isomer of ibuprofen suppresses acute pain and plasma beta-endorphin levels in the oral surgery model of acute pain.,"Is the triple ""Ibuprofen disrupts Acute Pain"" supported by the sentence: ""This study evaluated whether administration of the pharmacologically active S(+)-isomer of ibuprofen suppresses acute pain and plasma beta-endorphin levels in the oral surgery model of acute pain.""?",False, +23399675,Ibuprofen disrupts Myalgia,150,"On the other hand, in subgroup B, no improvement in flexibility or reduction in muscle soreness was found in patients who took ibuprofen.","Is the triple ""Ibuprofen disrupts Myalgia"" supported by the sentence: ""On the other hand, in subgroup B, no improvement in flexibility or reduction in muscle soreness was found in patients who took ibuprofen.""?",False, +18599970,Ibuprofen disrupts arthritic joint disease,151,"This is termed, Celery Seed Extract (CSE) and has been found to be at least as effective as aspirin, ibuprofen, and naproxen in suppressing arthritis in a model of polyarthritis.","Is the triple ""Ibuprofen disrupts arthritic joint disease"" supported by the sentence: ""This is termed, Celery Seed Extract (CSE) and has been found to be at least as effective as aspirin, ibuprofen, and naproxen in suppressing arthritis in a model of polyarthritis.""?",False, +15072611,Ibuprofen disrupts Fever,152,INTRODUCTION: Hospitalized patients are often unable to ingest or tolerate oral antipyretics and recently an aqueous formulation of intravenous (IV) ibuprofen was approved by the US-FDA for the reduction of fever in adults.,"Is the triple ""Ibuprofen disrupts Fever"" supported by the sentence: ""INTRODUCTION: Hospitalized patients are often unable to ingest or tolerate oral antipyretics and recently an aqueous formulation of intravenous (IV) ibuprofen was approved by the US-FDA for the reduction of fever in adults.""?",False, +14486259,Ibuprofen disrupts Pain,153,"OBJECTIVES: This study compared the analgesic effectiveness of acetaminophen-codeine with that of ibuprofen for children with acute traumatic extremity pain, with the hypothesis that the two medications would demonstrate equivalent reduction in pain scores in an emergency department (ED) setting.","Is the triple ""Ibuprofen disrupts Pain"" supported by the sentence: ""OBJECTIVES: This study compared the analgesic effectiveness of acetaminophen-codeine with that of ibuprofen for children with acute traumatic extremity pain, with the hypothesis that the two medications would demonstrate equivalent reduction in pain scores in an emergency department (ED) setting.""?",False, +8331095,Ibuprofen disrupts Alzheimer disease,154,"Thus, the anti-inflammatory drug ibuprofen, which has been associated with reduced AD risk in human epidemiological studies, can significantly delay some forms of AD pathology, including amyloid deposition, when administered early in the disease course of a transgenic mouse model of AD.","Is the triple ""Ibuprofen disrupts Alzheimer disease"" supported by the sentence: ""Thus, the anti-inflammatory drug ibuprofen, which has been associated with reduced AD risk in human epidemiological studies, can significantly delay some forms of AD pathology, including amyloid deposition, when administered early in the disease course of a transgenic mouse model of AD.""?",False, +25657729,Ibuprofen prevents hypertensive disorder,155,"The hypoxia, hypertension and increased prostanoids were prevented using ibuprofen.","Is the triple ""Ibuprofen prevents hypertensive disorder"" supported by the sentence: ""The hypoxia, hypertension and increased prostanoids were prevented using ibuprofen.""?",False, +22159382,Ibuprofen prevents Hemorrhage,156,"The Effect of Ibuprofen Dosing Interval on Post-Tonsillectomy Outcomes in Children: A Quality Improvement Study.OBJECTIVE: In this Quality Improvement (QI project) it was hypothesized that an increase in dosing intervals for postoperative analgesia when alternating Ibuprofen and Acetaminophen would reduce post-tonsillectomy hemorrhage (PTH) rates for those undergoing tonsillectomies with or without adenoidectomy, while maintaining the standard of postoperative analgesia and reducing visits to the Emergency Room (ER) for reasons other than PTH.","Is the triple ""Ibuprofen prevents Hemorrhage"" supported by the sentence: ""The Effect of Ibuprofen Dosing Interval on Post-Tonsillectomy Outcomes in Children: A Quality Improvement Study.OBJECTIVE: In this Quality Improvement (QI project) it was hypothesized that an increase in dosing intervals for postoperative analgesia when alternating Ibuprofen and Acetaminophen would reduce post-tonsillectomy hemorrhage (PTH) rates for those undergoing tonsillectomies with or without adenoidectomy, while maintaining the standard of postoperative analgesia and reducing visits to the Emergency Room (ER) for reasons other than PTH.""?",False, +22123299,Ibuprofen prevents Fever,157,Studies show that ibuprofen demonstrates superior efficacy in fever reduction compared to acetaminophen.,"Is the triple ""Ibuprofen prevents Fever"" supported by the sentence: ""Studies show that ibuprofen demonstrates superior efficacy in fever reduction compared to acetaminophen.""?",False, +21354514,Ibuprofen prevents pancreatitis,158,IV Ibuprofen for Prevention of Post-Ercp Pancreatitis in Children: A Randomized Placebo-Controlled Feasibility Study.,"Is the triple ""Ibuprofen prevents pancreatitis"" supported by the sentence: ""IV Ibuprofen for Prevention of Post-Ercp Pancreatitis in Children: A Randomized Placebo-Controlled Feasibility Study.""?",False, +20691057,Ibuprofen prevents altitude sickness,159,Altitude Sickness Prevention with Ibuprofen Relative to Acetazolamide.,"Is the triple ""Ibuprofen prevents altitude sickness"" supported by the sentence: ""Altitude Sickness Prevention with Ibuprofen Relative to Acetazolamide.""?",False, +19399624,Ibuprofen prevents osteoarthritis,160,"In conclusion, prednisone, ibuprofen and betamethasone may prevent OA by suppressing the expression of IL-6 and IL-8, subsequently inactivating NF-kappaB and STAT3 pathways, and ultimately, leading to decreased levels of collagen I, MMP-1, and MMP-13.","Is the triple ""Ibuprofen prevents osteoarthritis"" supported by the sentence: ""In conclusion, prednisone, ibuprofen and betamethasone may prevent OA by suppressing the expression of IL-6 and IL-8, subsequently inactivating NF-kappaB and STAT3 pathways, and ultimately, leading to decreased levels of collagen I, MMP-1, and MMP-13.""?",False, +17687542,Ibuprofen prevents canker sore,161,"This study aims to determine the therapeutic effects of ibuprofen, diphenhydramine and aluminum magnesium simethicone (AlMgS) syrup on reducing oral aphthous ulcer pain.","Is the triple ""Ibuprofen prevents canker sore"" supported by the sentence: ""This study aims to determine the therapeutic effects of ibuprofen, diphenhydramine and aluminum magnesium simethicone (AlMgS) syrup on reducing oral aphthous ulcer pain.""?",False, +15961024,Ibuprofen prevents Dysmenorrhea,162,"CONCLUSIONS: Considering the results of the study, reflexology was superior to Ibuprofen on reducing dysmenorrhea and its treatment effect continued even after discontinuing the intervention in the third cycle.","Is the triple ""Ibuprofen prevents Dysmenorrhea"" supported by the sentence: ""CONCLUSIONS: Considering the results of the study, reflexology was superior to Ibuprofen on reducing dysmenorrhea and its treatment effect continued even after discontinuing the intervention in the third cycle.""?",False, +13710734,Ibuprofen prevents Chronic pain,163,CONCLUSION: We conclude that pain therapy with an almost peripherally acting drug such as ibuprofen can reduce osteoporosis-associated chronic pain better than a centrally acting pain medication such as tramadol.,"Is the triple ""Ibuprofen prevents Chronic pain"" supported by the sentence: ""CONCLUSION: We conclude that pain therapy with an almost peripherally acting drug such as ibuprofen can reduce osteoporosis-associated chronic pain better than a centrally acting pain medication such as tramadol.""?",False, +10201705,Ibuprofen prevents Headache,164,The objective of this study was to determine whether pretreatment with ibuprofen would prevent the onset or decrease the severity of headache that occurs after ECT.,"Is the triple ""Ibuprofen prevents Headache"" supported by the sentence: ""The objective of this study was to determine whether pretreatment with ibuprofen would prevent the onset or decrease the severity of headache that occurs after ECT.""?",False, +10026105,Ibuprofen prevents Myalgia,165,The results of this study reveal that intake of ibuprofen can decrease muscle soreness induced after eccentric exercise but cannot assist in restoring muscle function.,"Is the triple ""Ibuprofen prevents Myalgia"" supported by the sentence: ""The results of this study reveal that intake of ibuprofen can decrease muscle soreness induced after eccentric exercise but cannot assist in restoring muscle function.""?",False, +9104502,Ibuprofen prevents injury,166,The objective of our study was to determine the role of ibuprofen in protecting neutropenic rats from cardiopulmonary injury due to endotoxemia.,"Is the triple ""Ibuprofen prevents injury"" supported by the sentence: ""The objective of our study was to determine the role of ibuprofen in protecting neutropenic rats from cardiopulmonary injury due to endotoxemia.""?",False, +9022792,Ibuprofen prevents Pain,167,"To determine if prophylactic etodolac would significantly reduce postendodontic pain, when compared with ibuprofen or placebo, 36 patients consented to single blind oral administration of either 400 mg of etodolac, 600 mg of ibuprofen, or a placebo, before conventional one-appointment root canal therapy.","Is the triple ""Ibuprofen prevents Pain"" supported by the sentence: ""To determine if prophylactic etodolac would significantly reduce postendodontic pain, when compared with ibuprofen or placebo, 36 patients consented to single blind oral administration of either 400 mg of etodolac, 600 mg of ibuprofen, or a placebo, before conventional one-appointment root canal therapy.""?",False, +8584177,Ibuprofen prevents patent ductus arteriosus,168,UNLABELLED: The aim of our study was to evaluate whether the prophylactic use of ibuprofen would reduce the incidence of significant patent ductus arteriosus (PDA) and to confirm the effectiveness of ibuprofen as rescue treatment in closing PDA.,"Is the triple ""Ibuprofen prevents patent ductus arteriosus"" supported by the sentence: ""UNLABELLED: The aim of our study was to evaluate whether the prophylactic use of ibuprofen would reduce the incidence of significant patent ductus arteriosus (PDA) and to confirm the effectiveness of ibuprofen as rescue treatment in closing PDA.""?",False, +7843138,Ibuprofen prevents Alzheimer disease,169,"Nonsteroidal anti-inflammatory drugs (NSAIDs) such as aspirin, indomethacin and ibuprofen are the most widely used drugs for pain, arthritis, cardiovascular diseases and, more recently, the prevention of colon cancer and Alzheimer disease.","Is the triple ""Ibuprofen prevents Alzheimer disease"" supported by the sentence: ""Nonsteroidal anti-inflammatory drugs (NSAIDs) such as aspirin, indomethacin and ibuprofen are the most widely used drugs for pain, arthritis, cardiovascular diseases and, more recently, the prevention of colon cancer and Alzheimer disease.""?",False, +15342704,Ibuprofen exacerbates injury,170,Aggravation of seizure-associated microvascular injuries by ibuprofen may involve multiple pathways.,"Is the triple ""Ibuprofen exacerbates injury"" supported by the sentence: ""Aggravation of seizure-associated microvascular injuries by ibuprofen may involve multiple pathways.""?",False, +20007370,Ibuprofen predisposes cerebral palsy,171,"Use of paracetamol, ibuprofen or aspirin in pregnancy and risk of cerebral palsy in the child.","Is the triple ""Ibuprofen predisposes cerebral palsy"" supported by the sentence: ""Use of paracetamol, ibuprofen or aspirin in pregnancy and risk of cerebral palsy in the child.""?",False, +14332005,Ibuprofen predisposes bronchopulmonary dysplasia,172,"More than two cycles of ibuprofen was significantly associated with an increased risk for bronchopulmonary dysplasia (odds ratio [OR], 2.81; p = 0.03) and acute renal failure (OR, 3.81; p = 0.09).","Is the triple ""Ibuprofen predisposes bronchopulmonary dysplasia"" supported by the sentence: ""More than two cycles of ibuprofen was significantly associated with an increased risk for bronchopulmonary dysplasia (odds ratio [OR], 2.81; p = 0.03) and acute renal failure (OR, 3.81; p = 0.09).""?",False, +14294004,Ibuprofen predisposes Alzheimer disease,173,OBJECTIVE: Non-steroidal anti-inflammatory drugs such as ibuprofen have a protective role on risk of Alzheimer's disease (AD).,"Is the triple ""Ibuprofen predisposes Alzheimer disease"" supported by the sentence: ""OBJECTIVE: Non-steroidal anti-inflammatory drugs such as ibuprofen have a protective role on risk of Alzheimer's disease (AD).""?",False, +14085648,Ibuprofen predisposes injury,174,"There seems to be a marked gradient of risk for acute kidney injury across agents, specifically for indomethacin, ibuprofen, and rofecoxib.","Is the triple ""Ibuprofen predisposes injury"" supported by the sentence: ""There seems to be a marked gradient of risk for acute kidney injury across agents, specifically for indomethacin, ibuprofen, and rofecoxib.""?",False, +12673407,Ibuprofen predisposes bone fracture,175,"Significant heterogeneity was present for the NSAIDs; e.g., ibuprofen was associated with an increased overall fracture risk (OR = 2.09, 95% CI 2.00-2.18 for <20 DDD), while celecoxib was not (OR = 0.76, 95% CI 0.51-1.13 for <20 DDD, 2P < 0.01 for comparison).","Is the triple ""Ibuprofen predisposes bone fracture"" supported by the sentence: ""Significant heterogeneity was present for the NSAIDs; e.g., ibuprofen was associated with an increased overall fracture risk (OR = 2.09, 95% CI 2.00-2.18 for <20 DDD), while celecoxib was not (OR = 0.76, 95% CI 0.51-1.13 for <20 DDD, 2P < 0.01 for comparison).""?",False, +17604344,Ivabradine related to diastolic heart failure,176,One should be more critical about ivabradine and low-dose digoxin in diastolic heart failure.,"Is the triple ""Ivabradine related to diastolic heart failure"" supported by the sentence: ""One should be more critical about ivabradine and low-dose digoxin in diastolic heart failure.""?",False, +19228519,Ivabradine causes atrial fibrillation,177,"Preclinical studies of ivabradine in animal models with induced AF demonstrated a reduction in HR, with no significant worsening of QT interval or mean arterial pressure.","Is the triple ""Ivabradine causes atrial fibrillation"" supported by the sentence: ""Preclinical studies of ivabradine in animal models with induced AF demonstrated a reduction in HR, with no significant worsening of QT interval or mean arterial pressure.""?",False, +20784958,Ivabradine affects atrial fibrillation,178,"In this review, we summarize the current knowledge of the HCN4 channel and ivabradine, including the function of HCN4 in cardiac pacemaking, the mechanism of action of If inhibition by ivabradine, and the pharmacological and clinical effects of ivabradine in cardiac diseases as HF, coronary artery disease, and atrial fibrillation.","Is the triple ""Ivabradine affects atrial fibrillation"" supported by the sentence: ""In this review, we summarize the current knowledge of the HCN4 channel and ivabradine, including the function of HCN4 in cardiac pacemaking, the mechanism of action of If inhibition by ivabradine, and the pharmacological and clinical effects of ivabradine in cardiac diseases as HF, coronary artery disease, and atrial fibrillation.""?",False, +20520107,Ivabradine affects mitral valve stenosis,179,Small studies have recently investigated the role of ivabradine in MS in sinus rhythm.,"Is the triple ""Ivabradine affects mitral valve stenosis"" supported by the sentence: ""Small studies have recently investigated the role of ivabradine in MS in sinus rhythm.""?",False, +20004006,Ivabradine affects diastolic heart failure,180,The role of Ivabradine in Diastolic Heart Failure with preserved Ejection Fraction.,"Is the triple ""Ivabradine affects diastolic heart failure"" supported by the sentence: ""The role of Ivabradine in Diastolic Heart Failure with preserved Ejection Fraction.""?",False, +15323309,Ivabradine affects cardiovascular disorder,181,"Other large trials are also underway to assess the effects of ivabradine on heart failure, acute coronary syndromes, CAD, and other cardiovascular disorders.","Is the triple ""Ivabradine affects cardiovascular disorder"" supported by the sentence: ""Other large trials are also underway to assess the effects of ivabradine on heart failure, acute coronary syndromes, CAD, and other cardiovascular disorders.""?",False, +15323306,Ivabradine affects coronary artery disorder,182,"Other large trials are also underway to assess the effects of ivabradine on heart failure, acute coronary syndromes, CAD, and other cardiovascular disorders.","Is the triple ""Ivabradine affects coronary artery disorder"" supported by the sentence: ""Other large trials are also underway to assess the effects of ivabradine on heart failure, acute coronary syndromes, CAD, and other cardiovascular disorders.""?",False, +19514713,Ivabradine disrupts atrial fibrillation,183,Effective suppression of atrial fibrillation by ivabradine: Novel target for an established drug?,"Is the triple ""Ivabradine disrupts atrial fibrillation"" supported by the sentence: ""Effective suppression of atrial fibrillation by ivabradine: Novel target for an established drug?""?",False, +17909104,Ivabradine disrupts coronary artery disorder,184,[SIGNIFY study is a disappointment. Ivabradine cannot stop of the progression of coronary heart disease].,"Is the triple ""Ivabradine disrupts coronary artery disorder"" supported by the sentence: ""[SIGNIFY study is a disappointment. Ivabradine cannot stop of the progression of coronary heart disease].""?",False, +17822394,Ivabradine prevents atrial fibrillation,185,RESULTS: Heart rate reduction and prevention of postoperative AF or tachyarrhythmia with combined therapy was more effective than with metoprolol or ivabradine alone during the immediate postoperative management of cardiac surgery patients.,"Is the triple ""Ivabradine prevents atrial fibrillation"" supported by the sentence: ""RESULTS: Heart rate reduction and prevention of postoperative AF or tachyarrhythmia with combined therapy was more effective than with metoprolol or ivabradine alone during the immediate postoperative management of cardiac surgery patients.""?",False, +10817471,Ivabradine prevents Tachycardia,186,"During exercise, ivabradine dose dependently and significantly reduced the exercise-induced tachycardia (-17, -21, and -32% at 0.25, 0.5, and 1 mg/kg, respectively, versus saline) without altering myocardial contractility nor mean ejection wall stress.","Is the triple ""Ivabradine prevents Tachycardia"" supported by the sentence: ""During exercise, ivabradine dose dependently and significantly reduced the exercise-induced tachycardia (-17, -21, and -32% at 0.25, 0.5, and 1 mg/kg, respectively, versus saline) without altering myocardial contractility nor mean ejection wall stress.""?",False, +19153602,Ivabradine predisposes atrial fibrillation,187,Recent trials reported that risk of atrial fibrillation (AF) is increased in patients using ivabradine compared with controls.,"Is the triple ""Ivabradine predisposes atrial fibrillation"" supported by the sentence: ""Recent trials reported that risk of atrial fibrillation (AF) is increased in patients using ivabradine compared with controls.""?",False, +15385004,Cefixime affects chronic bronchitis,188,Randomized comparative study of cefixime versus cephalexin in acute bacterial exacerbations of chronic bronchitis.,"Is the triple ""Cefixime affects chronic bronchitis"" supported by the sentence: ""Randomized comparative study of cefixime versus cephalexin in acute bacterial exacerbations of chronic bronchitis.""?",False, +15252860,Cefixime affects gonorrhea,189,Alterations of the pilQ gene in Neisseria gonorrhoeae are unlikely contributors to decreased susceptibility to ceftriaxone and cefixime in clinical gonococcal strains.,"Is the triple ""Cefixime affects gonorrhea"" supported by the sentence: ""Alterations of the pilQ gene in Neisseria gonorrhoeae are unlikely contributors to decreased susceptibility to ceftriaxone and cefixime in clinical gonococcal strains.""?",False, +18811968,Cefixime prevents otitis media,190,"Because of the emergence of these bacteria, other antimicrobial agents, both old and new, have been advocated for treatment and prevention of otitis media; amoxicillin-clavulanate, cefuroxime axetil, and cefixime are the newer agents.","Is the triple ""Cefixime prevents otitis media"" supported by the sentence: ""Because of the emergence of these bacteria, other antimicrobial agents, both old and new, have been advocated for treatment and prevention of otitis media; amoxicillin-clavulanate, cefuroxime axetil, and cefixime are the newer agents.""?",False, +17748395,Trimetazidine related to diabetic kidney disease,191,Experimental comparison of protective characteristics of enalapril and trimetazidine in diabetic nephropathy.,"Is the triple ""Trimetazidine related to diabetic kidney disease"" supported by the sentence: ""Experimental comparison of protective characteristics of enalapril and trimetazidine in diabetic nephropathy.""?",False, +22426756,Trimetazidine affects diabetic kidney disease,192,This study aimed to investigate the role of TMZ in diabetic nephropathy (DN) and its potential mechanisms.,"Is the triple ""Trimetazidine affects diabetic kidney disease"" supported by the sentence: ""This study aimed to investigate the role of TMZ in diabetic nephropathy (DN) and its potential mechanisms.""?",False, +21297588,Trimetazidine affects Cardiotoxicity,193,Objective: This study investigates the effect of TMZ in sunitinib-induced cardiotoxicity in vivo and in vitro and molecular mechanisms.,"Is the triple ""Trimetazidine affects Cardiotoxicity"" supported by the sentence: ""Objective: This study investigates the effect of TMZ in sunitinib-induced cardiotoxicity in vivo and in vitro and molecular mechanisms.""?",False, +19164679,Trimetazidine affects cardiovascular disorder,194,The role of trimetazidine in cardiovascular disease: beyond an anti-anginal agent.,"Is the triple ""Trimetazidine affects cardiovascular disorder"" supported by the sentence: ""The role of trimetazidine in cardiovascular disease: beyond an anti-anginal agent.""?",False, +18547788,Trimetazidine prevents Cardiotoxicity,195,"Trimetazidine, 2.5 mg/kg/day i.p. for 3 days before doxorubicin administration plus 2.5 mg/kg/day p.o. for 10 weeks, was unable to prevent the development of doxorubicin-induced long-term cardiotoxicity.","Is the triple ""Trimetazidine prevents Cardiotoxicity"" supported by the sentence: ""Trimetazidine, 2.5 mg/kg/day i.p. for 3 days before doxorubicin administration plus 2.5 mg/kg/day p.o. for 10 weeks, was unable to prevent the development of doxorubicin-induced long-term cardiotoxicity.""?",False, +13317799,Ranolazine causes atrial fibrillation,196,Ranolazine was more effective than lidocaine in terminating persistent AF and in preventing the induction of AF.,"Is the triple ""Ranolazine causes atrial fibrillation"" supported by the sentence: ""Ranolazine was more effective than lidocaine in terminating persistent AF and in preventing the induction of AF.""?",False, +19314329,Ranolazine affects cardiovascular disorder,197,Role of Ranolazine in cardiovascular disease and diabetes: Exploring beyond angina.,"Is the triple ""Ranolazine affects cardiovascular disorder"" supported by the sentence: ""Role of Ranolazine in cardiovascular disease and diabetes: Exploring beyond angina.""?",False, +19002641,Ranolazine affects atrial fibrillation,198,"Furthermore, the activated Akt/mTOR signaling pathway induced by AF was further activated by ranolazine.","Is the triple ""Ranolazine affects atrial fibrillation"" supported by the sentence: ""Furthermore, the activated Akt/mTOR signaling pathway induced by AF was further activated by ranolazine.""?",False, +17881291,Ranolazine affects type 2 diabetes mellitus,199,Recent evidence of beneficial effects of ranolazine (RAN) in type II diabetes motivates interest in the role of the late sodium current (INaL) in glucose-stimulated insulin secretion.,"Is the triple ""Ranolazine affects type 2 diabetes mellitus"" supported by the sentence: ""Recent evidence of beneficial effects of ranolazine (RAN) in type II diabetes motivates interest in the role of the late sodium current (INaL) in glucose-stimulated insulin secretion.""?",False, +16599546,Ranolazine affects atrial fibrillation,200,Effect of ranolazine in preventing postoperative atrial fibrillation in patients undergoing coronary revascularization surgery.,"Is the triple ""Ranolazine affects atrial fibrillation"" supported by the sentence: ""Effect of ranolazine in preventing postoperative atrial fibrillation in patients undergoing coronary revascularization surgery.""?",False, +15199166,Ranolazine affects myocardial ischemia,201,The anti-ischemic mechanism of action of ranolazine in stable ischemic heart disease.,"Is the triple ""Ranolazine affects myocardial ischemia"" supported by the sentence: ""The anti-ischemic mechanism of action of ranolazine in stable ischemic heart disease.""?",False, +13887428,Ranolazine disrupts atrial fibrillation,202,Atrial-selective/predominant sodium channel blockers such as ranolazine effectively suppress AF in experimental models of AF involving canine isolated right atrial preparations at concentrations that produce little to no effect on ventricular electrophysiologic parameters.,"Is the triple ""Ranolazine disrupts atrial fibrillation"" supported by the sentence: ""Atrial-selective/predominant sodium channel blockers such as ranolazine effectively suppress AF in experimental models of AF involving canine isolated right atrial preparations at concentrations that produce little to no effect on ventricular electrophysiologic parameters.""?",False, +17475563,Ranolazine prevents Angina pectoris,203,Ranolazine has been shown to decrease angina pectoris frequency and nitroglycerin consumption.,"Is the triple ""Ranolazine prevents Angina pectoris"" supported by the sentence: ""Ranolazine has been shown to decrease angina pectoris frequency and nitroglycerin consumption.""?",False, +14751648,Ranolazine prevents myocardial ischemia,204,BACKGROUND: Ranolazine has been shown to reduce myocardial ischemia and symptom severity among selected patients with chronic angina.,"Is the triple ""Ranolazine prevents myocardial ischemia"" supported by the sentence: ""BACKGROUND: Ranolazine has been shown to reduce myocardial ischemia and symptom severity among selected patients with chronic angina.""?",False, +14280230,Ranolazine prevents atrial fibrillation,205,"Dominant frequency (DF) of AF was reduced by ranolazine in left atrium from 11.7 (10.7-20.5) Hz to 7.6 (2.9-8.8) Hz (P = 0.02, n = 6).","Is the triple ""Ranolazine prevents atrial fibrillation"" supported by the sentence: ""Dominant frequency (DF) of AF was reduced by ranolazine in left atrium from 11.7 (10.7-20.5) Hz to 7.6 (2.9-8.8) Hz (P = 0.02, n = 6).""?",False, +17988674,Ranolazine predisposes atrial fibrillation,206,"After adjusting for potential sources of bias through propensity-score matched-pair analysis and conditional logistic regression, ranolazine was an independent predictor of preventing POAF (p < 0.0001).","Is the triple ""Ranolazine predisposes atrial fibrillation"" supported by the sentence: ""After adjusting for potential sources of bias through propensity-score matched-pair analysis and conditional logistic regression, ranolazine was an independent predictor of preventing POAF (p < 0.0001).""?",False, +26862829,Prednisolone related to multiple sclerosis,207,Prednisolone furthers T-cell immunodeficiency and also reduces the intensity of autoimmune reactions in multiple sclerosis.,"Is the triple ""Prednisolone related to multiple sclerosis"" supported by the sentence: ""Prednisolone furthers T-cell immunodeficiency and also reduces the intensity of autoimmune reactions in multiple sclerosis.""?",False, +26365803,Prednisolone related to adrenocortical insufficiency,208,[Pharmacokinetics of prednisolone in adrenal insufficiency ].,"Is the triple ""Prednisolone related to adrenocortical insufficiency"" supported by the sentence: ""[Pharmacokinetics of prednisolone in adrenal insufficiency ].""?",False, +26295217,Prednisolone related to angioimmunoblastic T-cell lymphoma,209,It is concluded that VAP is effective therapy in AIL.,"Is the triple ""Prednisolone related to angioimmunoblastic T-cell lymphoma"" supported by the sentence: ""It is concluded that VAP is effective therapy in AIL.""?",False, +26194122,Prednisolone related to synovitis,210,A thermographic assessment of three intra-articular prednisolone analogues given in rheumatoid synovitis.,"Is the triple ""Prednisolone related to synovitis"" supported by the sentence: ""A thermographic assessment of three intra-articular prednisolone analogues given in rheumatoid synovitis.""?",False, +25959730,Prednisolone related to sarcoma,211,The effect of small doses of prednisolone on the incidence of subcutaneous sarcomas induced by 3-methylcholanthrene in virgin female Swiss mice.,"Is the triple ""Prednisolone related to sarcoma"" supported by the sentence: ""The effect of small doses of prednisolone on the incidence of subcutaneous sarcomas induced by 3-methylcholanthrene in virgin female Swiss mice.""?",False, +25621708,Prednisolone related to uveitis,212,[Effects of chromocarb diethylamine and prednisolone in experimental uveitis induced by clove oil in rabbits].,"Is the triple ""Prednisolone related to uveitis"" supported by the sentence: ""[Effects of chromocarb diethylamine and prednisolone in experimental uveitis induced by clove oil in rabbits].""?",False, +24523226,Prednisolone related to glomerulonephritis,213,[Effect of prednisolone and heparin on circulating T- and B-lymphocytes in glomerulonephritis and systemic lupus erythematosus].,"Is the triple ""Prednisolone related to glomerulonephritis"" supported by the sentence: ""[Effect of prednisolone and heparin on circulating T- and B-lymphocytes in glomerulonephritis and systemic lupus erythematosus].""?",False, +23496152,Prednisolone related to subacute thyroiditis,214,[Effects of prednisolone on thyroidal-123I uptake in subacute thyroiditis].,"Is the triple ""Prednisolone related to subacute thyroiditis"" supported by the sentence: ""[Effects of prednisolone on thyroidal-123I uptake in subacute thyroiditis].""?",False, +22194722,Prednisolone related to pulmonary eosinophilia,215,"Blood Eosinophil Depletion with Mepolizumab, Benralizumab and Prednisolone in Eosinophilic Asthma.","Is the triple ""Prednisolone related to pulmonary eosinophilia"" supported by the sentence: ""Blood Eosinophil Depletion with Mepolizumab, Benralizumab and Prednisolone in Eosinophilic Asthma.""?",False, +21911849,Prednisolone related to habitual spontaneous abortion,216,[Prednisolone and aspirin combination therapy in habitual abortion with autoantibodies].,"Is the triple ""Prednisolone related to habitual spontaneous abortion"" supported by the sentence: ""[Prednisolone and aspirin combination therapy in habitual abortion with autoantibodies].""?",False, +20512112,Prednisolone related to castration-resistant prostate carcinoma,217,"To illustrate this, we used an example of cost-effectiveness analysis for docetaxel in combination with prednisolone in metastatic hormone-refractory prostate cancer.","Is the triple ""Prednisolone related to castration-resistant prostate carcinoma"" supported by the sentence: ""To illustrate this, we used an example of cost-effectiveness analysis for docetaxel in combination with prednisolone in metastatic hormone-refractory prostate cancer.""?",False, +20312000,Prednisolone related to chronic primary adrenal insufficiency,218,Prednisolone is associated with a worse bone mineral density in primary adrenal insufficiency.,"Is the triple ""Prednisolone related to chronic primary adrenal insufficiency"" supported by the sentence: ""Prednisolone is associated with a worse bone mineral density in primary adrenal insufficiency.""?",False, +20106181,Prednisolone related to allergic bronchopulmonary aspergillosis,219,CONCLUSIONS: Prednisolone was more effective in inducing response than itraconazole in acute-stage ABPA.,"Is the triple ""Prednisolone related to allergic bronchopulmonary aspergillosis"" supported by the sentence: ""CONCLUSIONS: Prednisolone was more effective in inducing response than itraconazole in acute-stage ABPA.""?",False, +19750187,Prednisolone related to lymphoma,220,"Purpose: The aim of this study was to compare asparaginase-related toxicities in two asparaginase preparations, namely native Escherichia coli L-asparaginase (L-ASP) and pegylated asparaginase (PEG-ASP) in combination with ifosfamide, methotrexate, etoposide, and prednisolone (IMEP) in natural killer (NK)/T-cell lymphoma (NTCL).","Is the triple ""Prednisolone related to lymphoma"" supported by the sentence: ""Purpose: The aim of this study was to compare asparaginase-related toxicities in two asparaginase preparations, namely native Escherichia coli L-asparaginase (L-ASP) and pegylated asparaginase (PEG-ASP) in combination with ifosfamide, methotrexate, etoposide, and prednisolone (IMEP) in natural killer (NK)/T-cell lymphoma (NTCL).""?",False, +17143213,Prednisolone related to temporal arteritis,221,Prednisolone combined with adjunctive immunosuppression is not superior to prednisolone alone in terms of efficacy and safety in giant cell arteritis: meta-analysis.,"Is the triple ""Prednisolone related to temporal arteritis"" supported by the sentence: ""Prednisolone combined with adjunctive immunosuppression is not superior to prednisolone alone in terms of efficacy and safety in giant cell arteritis: meta-analysis.""?",False, +16983852,Prednisolone related to Hodgkins lymphoma,222,CONCLUSION: GVP is well-tolerated regimen with high response rate and needs to be tested in late relapsed HL.,"Is the triple ""Prednisolone related to Hodgkins lymphoma"" supported by the sentence: ""CONCLUSION: GVP is well-tolerated regimen with high response rate and needs to be tested in late relapsed HL.""?",False, +16960031,Prednisolone related to psoriatic arthritis,223,Early treatment with addition of low dose prednisolone to methotrexate improves therapeutic outcome in severe psoriatic arthritis.,"Is the triple ""Prednisolone related to psoriatic arthritis"" supported by the sentence: ""Early treatment with addition of low dose prednisolone to methotrexate improves therapeutic outcome in severe psoriatic arthritis.""?",False, +16502712,Prednisolone related to aplastic anemia,224,"CONCLUSION: Flu/Cy/ATG conditioning regimen, bone marrow as stem cell source and CSA, prednisolone and short methotrexate regimen were associated with better survival in AA.","Is the triple ""Prednisolone related to aplastic anemia"" supported by the sentence: ""CONCLUSION: Flu/Cy/ATG conditioning regimen, bone marrow as stem cell source and CSA, prednisolone and short methotrexate regimen were associated with better survival in AA.""?",False, +16371065,Prednisolone related to celiac disease,225,Effect of addition of short course of prednisolone to gluten-free diet on mucosal epithelial cell regeneration and apoptosis in celiac disease: a pilot randomized controlled trial.,"Is the triple ""Prednisolone related to celiac disease"" supported by the sentence: ""Effect of addition of short course of prednisolone to gluten-free diet on mucosal epithelial cell regeneration and apoptosis in celiac disease: a pilot randomized controlled trial.""?",False, +16192798,Prednisolone related to dermatomyositis,226,Coadministration of cyclosporin a with prednisolone in acute interstitial pneumonia complicating polymyositis/dermatomyositis.,"Is the triple ""Prednisolone related to dermatomyositis"" supported by the sentence: ""Coadministration of cyclosporin a with prednisolone in acute interstitial pneumonia complicating polymyositis/dermatomyositis.""?",False, +16169223,Prednisolone related to mucocutaneous lymph node syndrome,227,"Efficacy of immunoglobulin plus prednisolone for prevention of coronary artery abnormalities in severe Kawasaki disease (RAISE study): a randomised, open-label, blinded-endpoints trial.","Is the triple ""Prednisolone related to mucocutaneous lymph node syndrome"" supported by the sentence: ""Efficacy of immunoglobulin plus prednisolone for prevention of coronary artery abnormalities in severe Kawasaki disease (RAISE study): a randomised, open-label, blinded-endpoints trial.""?",False, +16114172,Prednisolone related to plasma cell myeloma,228,"Response of vincristine, melphalan, cyclophosphamide and prednisolone in refractory multiple myeloma.","Is the triple ""Prednisolone related to plasma cell myeloma"" supported by the sentence: ""Response of vincristine, melphalan, cyclophosphamide and prednisolone in refractory multiple myeloma.""?",False, +14564343,Prednisolone related to acute lymphoblastic leukemia,229,Pyruvate kinase M2 and prednisolone resistance in acute lymphoblastic leukemia.,"Is the triple ""Prednisolone related to acute lymphoblastic leukemia"" supported by the sentence: ""Pyruvate kinase M2 and prednisolone resistance in acute lymphoblastic leukemia.""?",False, +13988965,Prednisolone related to osteoarthritis,230,"Stimulation with prednisolone and TNFalpha reduced GDF-5 expression in OA and RA fibroblasts, whereas MTX and IL-1beta revealed minor or no relevant change.","Is the triple ""Prednisolone related to osteoarthritis"" supported by the sentence: ""Stimulation with prednisolone and TNFalpha reduced GDF-5 expression in OA and RA fibroblasts, whereas MTX and IL-1beta revealed minor or no relevant change.""?",False, +13151963,Prednisolone related to diffuse large B-cell lymphoma,231,"A combination of rituximab plus chemotherapy, rituximab+cyclophosphamide+doxorubicin+vincristine+prednisolone (R-CHOP), has the highest efficacy ever described with any chemotherapy in DLBCL and FL.","Is the triple ""Prednisolone related to diffuse large B-cell lymphoma"" supported by the sentence: ""A combination of rituximab plus chemotherapy, rituximab+cyclophosphamide+doxorubicin+vincristine+prednisolone (R-CHOP), has the highest efficacy ever described with any chemotherapy in DLBCL and FL.""?",False, +13151962,Prednisolone related to follicular lymphoma,232,"A combination of rituximab plus chemotherapy, rituximab+cyclophosphamide+doxorubicin+vincristine+prednisolone (R-CHOP), has the highest efficacy ever described with any chemotherapy in DLBCL and FL.","Is the triple ""Prednisolone related to follicular lymphoma"" supported by the sentence: ""A combination of rituximab plus chemotherapy, rituximab+cyclophosphamide+doxorubicin+vincristine+prednisolone (R-CHOP), has the highest efficacy ever described with any chemotherapy in DLBCL and FL.""?",False, +12983495,Prednisolone related to prostate cancer,233,Weekly docetaxel and prednisolone versus prednisolone alone in androgen-independent prostate cancer: a randomized phase II study.,"Is the triple ""Prednisolone related to prostate cancer"" supported by the sentence: ""Weekly docetaxel and prednisolone versus prednisolone alone in androgen-independent prostate cancer: a randomized phase II study.""?",False, +12510603,Prednisolone related to membranous glomerulonephritis,234,Prednisolone and azathioprine in membranous nephropathy: a 10-year follow-up study.,"Is the triple ""Prednisolone related to membranous glomerulonephritis"" supported by the sentence: ""Prednisolone and azathioprine in membranous nephropathy: a 10-year follow-up study.""?",False, +12496746,Prednisolone related to neoplasm,235,"Taken together, the present study points to a strong inhibitory effect of liposomal PLP on tumor angiogenesis by reduction of the intratumoral production of the majority of pro-angiogenic factors studied and direct inhibition of endothelial cell proliferation, which is the result of high prolonged levels of prednisolone in the tumor by liposomal delivery.","Is the triple ""Prednisolone related to neoplasm"" supported by the sentence: ""Taken together, the present study points to a strong inhibitory effect of liposomal PLP on tumor angiogenesis by reduction of the intratumoral production of the majority of pro-angiogenic factors studied and direct inhibition of endothelial cell proliferation, which is the result of high prolonged levels of prednisolone in the tumor by liposomal delivery.""?",False, +12428137,Prednisolone related to croup,236,Prednisolone versus dexamethasone in croup: a randomised equivalence trial.,"Is the triple ""Prednisolone related to croup"" supported by the sentence: ""Prednisolone versus dexamethasone in croup: a randomised equivalence trial.""?",False, +12061894,Prednisolone related to West syndrome,237,Use of ACTH and prednisolone in infantile spasms: experience from a developing country.,"Is the triple ""Prednisolone related to West syndrome"" supported by the sentence: ""Use of ACTH and prednisolone in infantile spasms: experience from a developing country.""?",False, +11663099,Prednisolone related to Crohn disease,238,Bone mineral density in relation to efficacy and side effects of budesonide and prednisolone in Crohn's disease.,"Is the triple ""Prednisolone related to Crohn disease"" supported by the sentence: ""Bone mineral density in relation to efficacy and side effects of budesonide and prednisolone in Crohn's disease.""?",False, +11638013,Prednisolone related to eosinophilic granulomatosis with polyangiitis,239,OBJECTIVE: To examine the safety and efficacy of methotrexate (MTX) plus low-dose prednisolone for induction of remission in non life- or organ-threatening courses and for remission maintenance in Churg-Strauss syndrome (CSS).,"Is the triple ""Prednisolone related to eosinophilic granulomatosis with polyangiitis"" supported by the sentence: ""OBJECTIVE: To examine the safety and efficacy of methotrexate (MTX) plus low-dose prednisolone for induction of remission in non life- or organ-threatening courses and for remission maintenance in Churg-Strauss syndrome (CSS).""?",False, +11213963,Prednisolone related to leprosy,240,OBJECTIVE: To determine whether addition of low dose prednisolone to multidrug treatment can prevent reaction and nerve function impairment in leprosy.,"Is the triple ""Prednisolone related to leprosy"" supported by the sentence: ""OBJECTIVE: To determine whether addition of low dose prednisolone to multidrug treatment can prevent reaction and nerve function impairment in leprosy.""?",False, +11179224,Prednisolone related to alcoholic hepatitis,241,A double-blind randomized controlled trial of infliximab associated with prednisolone in acute alcoholic hepatitis.,"Is the triple ""Prednisolone related to alcoholic hepatitis"" supported by the sentence: ""A double-blind randomized controlled trial of infliximab associated with prednisolone in acute alcoholic hepatitis.""?",False, +11142916,Prednisolone related to lupus nephritis,242,EULAR randomised controlled trial of pulse cyclophosphamide and methylprednisolone versus continuous cyclophosphamide and prednisolone followed by azathioprine and prednisolone in lupus nephritis.,"Is the triple ""Prednisolone related to lupus nephritis"" supported by the sentence: ""EULAR randomised controlled trial of pulse cyclophosphamide and methylprednisolone versus continuous cyclophosphamide and prednisolone followed by azathioprine and prednisolone in lupus nephritis.""?",False, +11037266,Prednisolone related to granulomatosis with polyangiitis,243,OBJECTIVE: To investigate the safety and efficacy of leflunomide plus low-dose prednisolone for the maintenance of remission in Wegener's granulomatosis (WG).,"Is the triple ""Prednisolone related to granulomatosis with polyangiitis"" supported by the sentence: ""OBJECTIVE: To investigate the safety and efficacy of leflunomide plus low-dose prednisolone for the maintenance of remission in Wegener's granulomatosis (WG).""?",False, +11013570,Prednisolone related to leukemia,244,"Treatment with combined therapy of adriamycin, vincristine and prednisolone produced a remission in the leukaemia with complete resolution of the breast mass.","Is the triple ""Prednisolone related to leukemia"" supported by the sentence: ""Treatment with combined therapy of adriamycin, vincristine and prednisolone produced a remission in the leukaemia with complete resolution of the breast mass.""?",False, +10949449,Prednisolone related to polymyalgia rheumatica,245,RESULTS: The average initial dose of prednisolone in polymyalgia rheumatica was 35 mg; 51 of 62 patients were given a starting dose exceeding 15 mg.,"Is the triple ""Prednisolone related to polymyalgia rheumatica"" supported by the sentence: ""RESULTS: The average initial dose of prednisolone in polymyalgia rheumatica was 35 mg; 51 of 62 patients were given a starting dose exceeding 15 mg.""?",False, +10748640,Prednisolone related to infertility disorder,246,[Trans-utero-tubal administration of prednisolone in sterility caused by obstruction of the tubes].,"Is the triple ""Prednisolone related to infertility disorder"" supported by the sentence: ""[Trans-utero-tubal administration of prednisolone in sterility caused by obstruction of the tubes].""?",False, +10744705,"Prednisolone related to dermatitis, atopic",247,[On experiences with a combination preparation from prednisolone and an antihistaminic in dermatology especially in endogenous eczema].,"Is the triple ""Prednisolone related to dermatitis, atopic"" supported by the sentence: ""[On experiences with a combination preparation from prednisolone and an antihistaminic in dermatology especially in endogenous eczema].""?",False, +10736101,Prednisolone related to Graves disease,248,[USE OF PREDNISOLONE IN SOME GRAVE FORMS OF PATHOLOGY OF THE PREMATURE INFANT].,"Is the triple ""Prednisolone related to Graves disease"" supported by the sentence: ""[USE OF PREDNISOLONE IN SOME GRAVE FORMS OF PATHOLOGY OF THE PREMATURE INFANT].""?",False, +10735679,Prednisolone related to kidney disorder,249,[EFFECT OF PREDNISOLONE ON THE CARDIAC ACTIVITY IN LIVER AND KIDNEY DISEASES AND IN RHEUMATISM].,"Is the triple ""Prednisolone related to kidney disorder"" supported by the sentence: ""[EFFECT OF PREDNISOLONE ON THE CARDIAC ACTIVITY IN LIVER AND KIDNEY DISEASES AND IN RHEUMATISM].""?",False, +10715297,Prednisolone related to keratitis,250,"In this limited pilot study, we compared the effect on clinical outcome of treating Pseudomonas keratitis in guinea pigs with prednisolone (a corticosteroid), flurbiprofen (a cyclo-oxygenase inhibitor), nordihydroguaiaretic acid (a lipoxygenase inhibitor), and a leukotriene antagonist, SKF104353 [R-(R*, S*)]-beta-[(2-carboxyethyl) thio-alpha-hydroxy-2-(8-phenyloctyl) benzenepropanoic acid, zinc salt].","Is the triple ""Prednisolone related to keratitis"" supported by the sentence: ""In this limited pilot study, we compared the effect on clinical outcome of treating Pseudomonas keratitis in guinea pigs with prednisolone (a corticosteroid), flurbiprofen (a cyclo-oxygenase inhibitor), nordihydroguaiaretic acid (a lipoxygenase inhibitor), and a leukotriene antagonist, SKF104353 [R-(R*, S*)]-beta-[(2-carboxyethyl) thio-alpha-hydroxy-2-(8-phenyloctyl) benzenepropanoic acid, zinc salt].""?",False, +10703266,Prednisolone related to ulcerative colitis,251,URINARY EXCRETION OF PREDNISOLONE AFTER INTRARECTAL THERAPY IN ULCERATIVE COLITIS.,"Is the triple ""Prednisolone related to ulcerative colitis"" supported by the sentence: ""URINARY EXCRETION OF PREDNISOLONE AFTER INTRARECTAL THERAPY IN ULCERATIVE COLITIS.""?",False, +10687782,Prednisolone related to hepatocellular carcinoma,252,"Male rats treated with either budesonide, prednisolone, or triamcinolone acetonide in drinking water for up to 104 weeks developed slightly increased incidences of basophilic foci, and significantly increased incidences of combined hepatocellular adenomas/carcinomas as compared to controls.","Is the triple ""Prednisolone related to hepatocellular carcinoma"" supported by the sentence: ""Male rats treated with either budesonide, prednisolone, or triamcinolone acetonide in drinking water for up to 104 weeks developed slightly increased incidences of basophilic foci, and significantly increased incidences of combined hepatocellular adenomas/carcinomas as compared to controls.""?",False, +10623724,Prednisolone related to hemolytic anemia,253,[On the use of prednisolone in hemolytic anemia of the newborn caused by fetomaternal Rh-factor incompatibility].,"Is the triple ""Prednisolone related to hemolytic anemia"" supported by the sentence: ""[On the use of prednisolone in hemolytic anemia of the newborn caused by fetomaternal Rh-factor incompatibility].""?",False, +10576837,Prednisolone related to juvenile idiopathic arthritis,254,Long-term use of prednisone and prednisolone in juvenile rheumatoid arthritis; a report of fifteen cases.,"Is the triple ""Prednisolone related to juvenile idiopathic arthritis"" supported by the sentence: ""Long-term use of prednisone and prednisolone in juvenile rheumatoid arthritis; a report of fifteen cases.""?",False, +10565620,Prednisolone related to nephrotic syndrome,255,[Effect of prednisolone and human albumin on protein excretion in nephrotic syndrome].,"Is the triple ""Prednisolone related to nephrotic syndrome"" supported by the sentence: ""[Effect of prednisolone and human albumin on protein excretion in nephrotic syndrome].""?",False, +10531966,Prednisolone related to allergic disease,256,[Therapeutic results of metacortandralone or prednisolone in allergy].,"Is the triple ""Prednisolone related to allergic disease"" supported by the sentence: ""[Therapeutic results of metacortandralone or prednisolone in allergy].""?",False, +10527508,Prednisolone related to acute myeloid leukemia,257,Primary resistance to vincristine (Vcr) and prednisolone in untreated AML was observed as well as 'acquired' resistance to several other antileukemic drugs.,"Is the triple ""Prednisolone related to acute myeloid leukemia"" supported by the sentence: ""Primary resistance to vincristine (Vcr) and prednisolone in untreated AML was observed as well as 'acquired' resistance to several other antileukemic drugs.""?",False, +10503828,Prednisolone related to seasonal allergic rhinitis,258,"REPORT of the Committee on New Drugs of the Research Council of the American Academy of Allergy, 1955-56; studies on prednisone and prednisolone in ragweed pollinosis.","Is the triple ""Prednisolone related to seasonal allergic rhinitis"" supported by the sentence: ""REPORT of the Committee on New Drugs of the Research Council of the American Academy of Allergy, 1955-56; studies on prednisone and prednisolone in ragweed pollinosis.""?",False, +10496403,Prednisolone related to Inflammation,259,Effects of prednisone and prednisolone in ocular inflammation.,"Is the triple ""Prednisolone related to Inflammation"" supported by the sentence: ""Effects of prednisone and prednisolone in ocular inflammation.""?",False, +10118116,Prednisolone related to Prednisone,260,"Prednisolone scored better than prednisone in the categories of texture, taste, and aftertaste (p < 0.05); there was no statistical difference in smell.","Is the triple ""Prednisolone related to Prednisone"" supported by the sentence: ""Prednisolone scored better than prednisone in the categories of texture, taste, and aftertaste (p < 0.05); there was no statistical difference in smell.""?",False, +9924521,Prednisolone related to colitis,261,Plasma prednisolone levels after administration of prednisolone-21-phosphate as a retention enema in colitis.,"Is the triple ""Prednisolone related to colitis"" supported by the sentence: ""Plasma prednisolone levels after administration of prednisolone-21-phosphate as a retention enema in colitis.""?",False, +9437304,Prednisolone related to systemic lupus erythematosus,262,Mizoribine as an effective combined maintenance therapy with prednisolone in child-onset systemic lupus erythematosus.,"Is the triple ""Prednisolone related to systemic lupus erythematosus"" supported by the sentence: ""Mizoribine as an effective combined maintenance therapy with prednisolone in child-onset systemic lupus erythematosus.""?",False, +9282196,Prednisolone related to IgA glomerulonephritis,263,Controlled prospective trial of prednisolone and cytotoxics in progressive IgA nephropathy.,"Is the triple ""Prednisolone related to IgA glomerulonephritis"" supported by the sentence: ""Controlled prospective trial of prednisolone and cytotoxics in progressive IgA nephropathy.""?",False, +9222009,Prednisolone related to hypereosinophilic syndrome,264,"We propose that FE(NO) is associated with eosinophilic inflammation in children with difficult asthma, following prednisolone, and may help in identifying patients in whom persistent symptoms are associated with airway eosinophilia.","Is the triple ""Prednisolone related to hypereosinophilic syndrome"" supported by the sentence: ""We propose that FE(NO) is associated with eosinophilic inflammation in children with difficult asthma, following prednisolone, and may help in identifying patients in whom persistent symptoms are associated with airway eosinophilia.""?",False, +9216084,Prednisolone related to non-Hodgkin lymphoma,265,"Liposomal daunorubicin (DaunoXome) in combination with cyclophosphamide, vincristine and prednisolone (COP-X) as salvage therapy in poor-prognosis non-Hodgkins lymphoma.","Is the triple ""Prednisolone related to non-Hodgkin lymphoma"" supported by the sentence: ""Liposomal daunorubicin (DaunoXome) in combination with cyclophosphamide, vincristine and prednisolone (COP-X) as salvage therapy in poor-prognosis non-Hodgkins lymphoma.""?",False, +9208405,Prednisolone related to Duchenne muscular dystrophy,266,Prednisolone in Duchenne muscular dystrophy.,"Is the triple ""Prednisolone related to Duchenne muscular dystrophy"" supported by the sentence: ""Prednisolone in Duchenne muscular dystrophy.""?",False, +8405261,Prednisolone related to asthma,267,Intravenous prednisolone in chronic bronchial asthma.,"Is the triple ""Prednisolone related to asthma"" supported by the sentence: ""Intravenous prednisolone in chronic bronchial asthma.""?",False, +7844202,Prednisolone related to chronic obstructive pulmonary disease,268,Reversibility with prednisolone is rarely seen in COPD.,"Is the triple ""Prednisolone related to chronic obstructive pulmonary disease"" supported by the sentence: ""Reversibility with prednisolone is rarely seen in COPD.""?",False, +7323744,Prednisolone related to pemphigus,269,"In spite of the fact that prednisolone-based treatment of pemphigus patients has proved to be effective in controlling the disease, some undesirable effects associated with this form of treatment have prompted investigation into other therapeutic approaches.","Is the triple ""Prednisolone related to pemphigus"" supported by the sentence: ""In spite of the fact that prednisolone-based treatment of pemphigus patients has proved to be effective in controlling the disease, some undesirable effects associated with this form of treatment have prompted investigation into other therapeutic approaches.""?",False, +7262473,Prednisolone related to rheumatoid arthritis,270,One reason for the good clinical effects of prednisolone in RA could be a down-regulation of adhesion and phagocytosis receptors on monocytes.,"Is the triple ""Prednisolone related to rheumatoid arthritis"" supported by the sentence: ""One reason for the good clinical effects of prednisolone in RA could be a down-regulation of adhesion and phagocytosis receptors on monocytes.""?",False, +7206314,Prednisolone related to pulmonary tuberculosis,271,OBJECTIVE: To appraise the adjunctive role of prednisolone (PN) in pulmonary tuberculosis (PTB) with toxic reactions.,"Is the triple ""Prednisolone related to pulmonary tuberculosis"" supported by the sentence: ""OBJECTIVE: To appraise the adjunctive role of prednisolone (PN) in pulmonary tuberculosis (PTB) with toxic reactions.""?",False, +8856354,Prednisolone related to Prednisone,272,"A significant reduction of survival was found with the presence of permanent visual loss vs absence (p = 0.04), in patients who required more than 10 mg/d of glucocorticoid (p < 0.001) at 6 months treatment and in patients treated with prednisone (vs prednisolone) (p < 0.01).","Is the triple ""Prednisolone related to Prednisone"" supported by the sentence: ""A significant reduction of survival was found with the presence of permanent visual loss vs absence (p = 0.04), in patients who required more than 10 mg/d of glucocorticoid (p < 0.001) at 6 months treatment and in patients treated with prednisone (vs prednisolone) (p < 0.01).""?",False, +26879702,Prednisolone has part acute lymphoblastic leukemia,273,"Fourteen patients developed hyperglycemia during induction therapy of acute lymphoblastic leukemia with L-asparaginase, prednisolone, vincristine and daunorubicin.","Is the triple ""Prednisolone has part acute lymphoblastic leukemia"" supported by the sentence: ""Fourteen patients developed hyperglycemia during induction therapy of acute lymphoblastic leukemia with L-asparaginase, prednisolone, vincristine and daunorubicin.""?",False, +26670577,Prednisolone has part plasma cell myeloma,274,A 66-year-old man was treated for IgD (lambda) multiple myeloma with 2mg/day melphalan and 20mg/day prednisolone.,"Is the triple ""Prednisolone has part plasma cell myeloma"" supported by the sentence: ""A 66-year-old man was treated for IgD (lambda) multiple myeloma with 2mg/day melphalan and 20mg/day prednisolone.""?",False, +18935086,Prednisolone coexists with Prednisone,275,"Moreover, after recent findings regarding the presence of endogenous prednisolone in the urine of more popular breeds, particular attention was given to analysis of the presence of prednisolone and prednisone, as well.","Is the triple ""Prednisolone coexists with Prednisone"" supported by the sentence: ""Moreover, after recent findings regarding the presence of endogenous prednisolone in the urine of more popular breeds, particular attention was given to analysis of the presence of prednisolone and prednisone, as well.""?",False, +9296680,Prednisolone derives from Prednisone,276,"Of 10 mg of prednisone given orally to 5 normal subjects, 69+/-5% was absorbed and converted to peripheral plasma prednisolone within 8 h.","Is the triple ""Prednisolone derives from Prednisone"" supported by the sentence: ""Of 10 mg of prednisone given orally to 5 normal subjects, 69+/-5% was absorbed and converted to peripheral plasma prednisolone within 8 h.""?",False, +26415442,Prednisolone derives from Prednisone,277,"As in humans, prednisolone was partly converted to prednisone in the rabbit.","Is the triple ""Prednisolone derives from Prednisone"" supported by the sentence: ""As in humans, prednisolone was partly converted to prednisone in the rabbit.""?",False, +14808035,Prednisolone physically interacts with Prednisone,278,"Given the close resemblance of the ring A structure of prednisolone and prednisone on the one hand, and of androstadienedione on the other, the transformation of cortisol and cortisone into prednisolone and prednisone in cattle faeces was evaluated.","Is the triple ""Prednisolone physically interacts with Prednisone"" supported by the sentence: ""Given the close resemblance of the ring A structure of prednisolone and prednisone on the one hand, and of androstadienedione on the other, the transformation of cortisol and cortisone into prednisolone and prednisone in cattle faeces was evaluated.""?",False, +9296682,Prednisolone physically interacts with Prednisone,279,The data indicate that prednisone is extensively metabolized to prednisolone before it clears the splanchnic circulation and the formation prednisone by oxidation of the 11-hydorxyl group of prednisolone appears to occur mainly in peripheral tissues.,"Is the triple ""Prednisolone physically interacts with Prednisone"" supported by the sentence: ""The data indicate that prednisone is extensively metabolized to prednisolone before it clears the splanchnic circulation and the formation prednisone by oxidation of the 11-hydorxyl group of prednisolone appears to occur mainly in peripheral tissues.""?",False, +27055840,Prednisolone causes glaucoma,280,CONCLUSION: Dexamethasone or prednisolone were the easiest to induce steroid glaucoma when the patients had long-term use of steroid eyedrops.,"Is the triple ""Prednisolone causes glaucoma"" supported by the sentence: ""CONCLUSION: Dexamethasone or prednisolone were the easiest to induce steroid glaucoma when the patients had long-term use of steroid eyedrops.""?",False, +26677891,Prednisolone causes uveitis,281,"Among 121 CK-analogs studied, CK-17, CK-101A and CK103A have been identified as promising anti-inflammatory agents as potent as prednisolone in inhibiting lens proteins-induced inflammation and twice as potent as prednisolone in inhibiting endotoxin-and IL-1-induced uveitis.","Is the triple ""Prednisolone causes uveitis"" supported by the sentence: ""Among 121 CK-analogs studied, CK-17, CK-101A and CK103A have been identified as promising anti-inflammatory agents as potent as prednisolone in inhibiting lens proteins-induced inflammation and twice as potent as prednisolone in inhibiting endotoxin-and IL-1-induced uveitis.""?",False, +25953223,Prednisolone causes kidney disorder,282,Light and electron microscopy of prednisolone-induced nephropathy in rabbits.,"Is the triple ""Prednisolone causes kidney disorder"" supported by the sentence: ""Light and electron microscopy of prednisolone-induced nephropathy in rabbits.""?",False, +21556285,Prednisolone causes allergic disease,283,The behavior results showed that exposure to prednisolone resulted in decreased autonomic activity and low sensitivity to light.,"Is the triple ""Prednisolone causes allergic disease"" supported by the sentence: ""The behavior results showed that exposure to prednisolone resulted in decreased autonomic activity and low sensitivity to light.""?",False, +21293782,Prednisolone causes adrenocortical insufficiency,284,We therefore advocate for increased clinical alertness towards prednisolone-induced adrenal insufficiency in RTx patients and thus their potential need of rescue GC supplementation during stress.,"Is the triple ""Prednisolone causes adrenocortical insufficiency"" supported by the sentence: ""We therefore advocate for increased clinical alertness towards prednisolone-induced adrenal insufficiency in RTx patients and thus their potential need of rescue GC supplementation during stress.""?",False, +20789636,Prednisolone causes ulcerative colitis,285,Zeaxanthin (50 mg/kg/day) or prednisolone (5 mg/kg/day) was orally administered for 14 days before induction of ulcerative colitis.,"Is the triple ""Prednisolone causes ulcerative colitis"" supported by the sentence: ""Zeaxanthin (50 mg/kg/day) or prednisolone (5 mg/kg/day) was orally administered for 14 days before induction of ulcerative colitis.""?",False, +17230021,Prednisolone causes Headache,286,"OBJECTIVE: We want to show that an intralesional injection of prednisolone into the proximal nail fold may produce dorsal pain, dyspnoea and headaches within the 2 min following the injection and to explain the pathophysiology of his condition.","Is the triple ""Prednisolone causes Headache"" supported by the sentence: ""OBJECTIVE: We want to show that an intralesional injection of prednisolone into the proximal nail fold may produce dorsal pain, dyspnoea and headaches within the 2 min following the injection and to explain the pathophysiology of his condition.""?",False, +16304261,Prednisolone causes nephrotic syndrome,287,[A case of nephrotic syndrome with abnormally high level of protein C induced by prednisolone].,"Is the triple ""Prednisolone causes nephrotic syndrome"" supported by the sentence: ""[A case of nephrotic syndrome with abnormally high level of protein C induced by prednisolone].""?",False, +15365269,Prednisolone causes infertility disorder,288,It is concluded that six or more cycles of COPP chemotherapy for advanced Hodgkin's disease in men leads to permanent sterility.,"Is the triple ""Prednisolone causes infertility disorder"" supported by the sentence: ""It is concluded that six or more cycles of COPP chemotherapy for advanced Hodgkin's disease in men leads to permanent sterility.""?",False, +14373522,Prednisolone causes exfoliative dermatitis,289,The erythroderma improved generally as a result of systemic prednisolone treatment.,"Is the triple ""Prednisolone causes exfoliative dermatitis"" supported by the sentence: ""The erythroderma improved generally as a result of systemic prednisolone treatment.""?",False, +10735861,Prednisolone causes contact dermatitis,290,CONTACT DERMATITIS DUE TO TOPICAL HYDROCORTISONE AND PREDNISOLONE.,"Is the triple ""Prednisolone causes contact dermatitis"" supported by the sentence: ""CONTACT DERMATITIS DUE TO TOPICAL HYDROCORTISONE AND PREDNISOLONE.""?",False, +10545904,Prednisolone causes pulmonary tuberculosis,291,[Pulmonary tuberculosis due to prednisolone].,"Is the triple ""Prednisolone causes pulmonary tuberculosis"" supported by the sentence: ""[Pulmonary tuberculosis due to prednisolone].""?",False, +10519611,Prednisolone causes colitis,292,"Rats were treated with a leukotriene synthesis inhibitor (PF-5901), a leukotriene B4 receptor antagonist (SC-41930), an IL-1 receptor antagonist or a corticosteroid (prednisolone) prior to induction of colitis.","Is the triple ""Prednisolone causes colitis"" supported by the sentence: ""Rats were treated with a leukotriene synthesis inhibitor (PF-5901), a leukotriene B4 receptor antagonist (SC-41930), an IL-1 receptor antagonist or a corticosteroid (prednisolone) prior to induction of colitis.""?",False, +9464043,Prednisolone causes cataract,293,"PURPOSE: To investigate the relationship between vitamin E deficiency and prednisolone-induced cataract formation, long-term examination of lens changes was performed in rats under the condition of vitamin E deficiency or supplementation and administration of prednisolone.","Is the triple ""Prednisolone causes cataract"" supported by the sentence: ""PURPOSE: To investigate the relationship between vitamin E deficiency and prednisolone-induced cataract formation, long-term examination of lens changes was performed in rats under the condition of vitamin E deficiency or supplementation and administration of prednisolone.""?",False, +8757881,Prednisolone causes systemic lupus erythematosus,294,"In inactive SLE induced by prednisolone therapy, the invariant Valpha24JalphaQ TCR could be detected in DN Valpha24+ T cells from all the patients and dominated in most of the patients.","Is the triple ""Prednisolone causes systemic lupus erythematosus"" supported by the sentence: ""In inactive SLE induced by prednisolone therapy, the invariant Valpha24JalphaQ TCR could be detected in DN Valpha24+ T cells from all the patients and dominated in most of the patients.""?",False, +27658451,Prednisolone affects uveitis,295,"Interleukin-1 (IL-1) blockers, CK 127 and CK 129, were found to inhibit IL-1-induced posterior uveitis very effectively at 3-10 mg/kg i.p. and were more potent than prednisolone which required at least 20 mg/kg i.p. to achieve the same level of anti-uveitis action.","Is the triple ""Prednisolone affects uveitis"" supported by the sentence: ""Interleukin-1 (IL-1) blockers, CK 127 and CK 129, were found to inhibit IL-1-induced posterior uveitis very effectively at 3-10 mg/kg i.p. and were more potent than prednisolone which required at least 20 mg/kg i.p. to achieve the same level of anti-uveitis action.""?",False, +27410586,Prednisolone affects castration-resistant prostate carcinoma,296,[A case of hormone-refractory prostate cancer responsive to low-dose prednisolone therapy].,"Is the triple ""Prednisolone affects castration-resistant prostate carcinoma"" supported by the sentence: ""[A case of hormone-refractory prostate cancer responsive to low-dose prednisolone therapy].""?",False, +27323391,Prednisolone affects focal segmental glomerulosclerosis,297,6 cases of FSGS had poor response to any therapy; 7 cases were responsive to either triple therapy or cyclosporine A plus prednisolone.,"Is the triple ""Prednisolone affects focal segmental glomerulosclerosis"" supported by the sentence: ""6 cases of FSGS had poor response to any therapy; 7 cases were responsive to either triple therapy or cyclosporine A plus prednisolone.""?",False, +27042309,Prednisolone affects pulmonary eosinophilia,298,"From 1983, exacerbation of PIE was recorded three times, on which occasions prednisolone and antibiotics were quite effective.","Is the triple ""Prednisolone affects pulmonary eosinophilia"" supported by the sentence: ""From 1983, exacerbation of PIE was recorded three times, on which occasions prednisolone and antibiotics were quite effective.""?",False, +25790510,Prednisolone affects allergic disease,299,"A comparative study of the effects of ACTH, hydrocortisone and prednisolone in the hypersensitive reactions produced with the protein components of Hymenolepis nana in albino mice.","Is the triple ""Prednisolone affects allergic disease"" supported by the sentence: ""A comparative study of the effects of ACTH, hydrocortisone and prednisolone in the hypersensitive reactions produced with the protein components of Hymenolepis nana in albino mice.""?",False, +25165576,Prednisolone affects glomerulonephritis,300,"Immunosuppressant therapy, such as prednisolone or azathioprine, is considered for exacerbations of highly active glomerulonephritis.","Is the triple ""Prednisolone affects glomerulonephritis"" supported by the sentence: ""Immunosuppressant therapy, such as prednisolone or azathioprine, is considered for exacerbations of highly active glomerulonephritis.""?",False, +24270725,Prednisolone affects dermatomyositis,301,"We describe a 57-year-old Caucasian male with anti-MDA5 positive dermatomyositis, that had a 4-month history of progressive dyspnoea requiring oxygen-therapy, scarcely responsive to prednisolone.","Is the triple ""Prednisolone affects dermatomyositis"" supported by the sentence: ""We describe a 57-year-old Caucasian male with anti-MDA5 positive dermatomyositis, that had a 4-month history of progressive dyspnoea requiring oxygen-therapy, scarcely responsive to prednisolone.""?",False, +22922261,Prednisolone affects allergic bronchopulmonary aspergillosis,302,"After 14 months of treatment one of the patients developed severe, acute exacerbation of the ABPA and was treated with high-dose prednisolone and local steroid.","Is the triple ""Prednisolone affects allergic bronchopulmonary aspergillosis"" supported by the sentence: ""After 14 months of treatment one of the patients developed severe, acute exacerbation of the ABPA and was treated with high-dose prednisolone and local steroid.""?",False, +19824794,Prednisolone affects colitis,303,"The effect of pretreatment with topical prostaglandin E2, prednisolone and sulphasalazine in experimental colitis has been examined in the rat colon.","Is the triple ""Prednisolone affects colitis"" supported by the sentence: ""The effect of pretreatment with topical prostaglandin E2, prednisolone and sulphasalazine in experimental colitis has been examined in the rat colon.""?",False, +19409335,Prednisolone affects sarcoidosis,304,"Here, we report a case of prednisolone-dependent gastric sarcoidosis that improved after additional azathioprine, and also review the literature concerning the treatment, especially for prednisolone-dependent cases.","Is the triple ""Prednisolone affects sarcoidosis"" supported by the sentence: ""Here, we report a case of prednisolone-dependent gastric sarcoidosis that improved after additional azathioprine, and also review the literature concerning the treatment, especially for prednisolone-dependent cases.""?",False, +18736907,Prednisolone affects asthma,305,"METHODS: In 126 adults (33 healthy control subjects, 31 patients with mild asthma, 32 patients with severe asthma, and 30 patients with prednisolone-dependent asthma) parameters of inflammation (peripheral blood eosinophils and neutrophils) and markers of hemostasis (endogenous thrombin potential [ETP], thrombin-antithrombin complex, plasmin-alpha2-antiplasmin complex, plasminogen activator inhibitor type 1 [PAI-1], D-dimer, and von Willebrand factor [vWF]) were measured in plasma.","Is the triple ""Prednisolone affects asthma"" supported by the sentence: ""METHODS: In 126 adults (33 healthy control subjects, 31 patients with mild asthma, 32 patients with severe asthma, and 30 patients with prednisolone-dependent asthma) parameters of inflammation (peripheral blood eosinophils and neutrophils) and markers of hemostasis (endogenous thrombin potential [ETP], thrombin-antithrombin complex, plasmin-alpha2-antiplasmin complex, plasminogen activator inhibitor type 1 [PAI-1], D-dimer, and von Willebrand factor [vWF]) were measured in plasma.""?",False, +17668631,Prednisolone affects Prednisone,306,Previous studies from our laboratory revealed that coadministration of EP significantly increased the plasma concentration of prednisolone while decreased the level of cotreated prednisone in rats.,"Is the triple ""Prednisolone affects Prednisone"" supported by the sentence: ""Previous studies from our laboratory revealed that coadministration of EP significantly increased the plasma concentration of prednisolone while decreased the level of cotreated prednisone in rats.""?",False, +15888410,Prednisolone affects rheumatoid arthritis,307,Metabolic effects of high-dose prednisolone treatment in early rheumatoid arthritis: balance between diabetogenic effects and inflammation reduction.,"Is the triple ""Prednisolone affects rheumatoid arthritis"" supported by the sentence: ""Metabolic effects of high-dose prednisolone treatment in early rheumatoid arthritis: balance between diabetogenic effects and inflammation reduction.""?",False, +13564625,Prednisolone affects asthma,308,"Effects of prednisolone, salbutamol and theophylline on bronchial hyperreactivity and leucocyte chemokinesis in guinea pigs.","Is the triple ""Prednisolone affects asthma"" supported by the sentence: ""Effects of prednisolone, salbutamol and theophylline on bronchial hyperreactivity and leucocyte chemokinesis in guinea pigs.""?",False, +13234063,Prednisolone affects pericarditis,309,"This is the first case to support the beneficial effect of prednisolone in pericarditis with pSS, and illustrates its safety during pregnancy.","Is the triple ""Prednisolone affects pericarditis"" supported by the sentence: ""This is the first case to support the beneficial effect of prednisolone in pericarditis with pSS, and illustrates its safety during pregnancy.""?",False, +13029310,Prednisolone affects chronic obstructive pulmonary disease,310,"When combined with environmental control, prednisolone and dexamethasone treatments had similar effects on heaves score, blood gases and endoscopic scores.","Is the triple ""Prednisolone affects chronic obstructive pulmonary disease"" supported by the sentence: ""When combined with environmental control, prednisolone and dexamethasone treatments had similar effects on heaves score, blood gases and endoscopic scores.""?",False, +12949384,Prednisolone affects hypereosinophilic syndrome,311,"Of the 20 patients, 14 initially received prednisolone treatment, which resulted in rapid improvement and normalization of eosinophilia within 8 weeks; however, 2 patients with splenomegaly showed poor control of eosinophilia in response to corticosteroid treatment.","Is the triple ""Prednisolone affects hypereosinophilic syndrome"" supported by the sentence: ""Of the 20 patients, 14 initially received prednisolone treatment, which resulted in rapid improvement and normalization of eosinophilia within 8 weeks; however, 2 patients with splenomegaly showed poor control of eosinophilia in response to corticosteroid treatment.""?",False, +12057849,Prednisolone affects Crohn disease,312,Complement activation capacity in plasma before and during high-dose prednisolone treatment and tapering in exacerbations of Crohn's disease and ulcerative colitis.,"Is the triple ""Prednisolone affects Crohn disease"" supported by the sentence: ""Complement activation capacity in plasma before and during high-dose prednisolone treatment and tapering in exacerbations of Crohn's disease and ulcerative colitis.""?",False, +11166436,Prednisolone affects Headache,313,Prednisolone-responsive headache in patients with solitary cysticercus granuloma and seizures.,"Is the triple ""Prednisolone affects Headache"" supported by the sentence: ""Prednisolone-responsive headache in patients with solitary cysticercus granuloma and seizures.""?",False, +11074135,Prednisolone affects lymphoma,314,"The patient was treated with chemotherapy by cyclophosphamide, hydroxydoxorubicin, vincristine and prednisolone (CHOP), however, it was ineffective, and the patient died of hemorrhage from the lymphoma involvement of the intestine 5 months after the onset of disease.","Is the triple ""Prednisolone affects lymphoma"" supported by the sentence: ""The patient was treated with chemotherapy by cyclophosphamide, hydroxydoxorubicin, vincristine and prednisolone (CHOP), however, it was ineffective, and the patient died of hemorrhage from the lymphoma involvement of the intestine 5 months after the onset of disease.""?",False, +10651502,Prednisolone affects kidney disorder,315,Effect of prednisolone in the experimentally induced nephropathy in male albino rats.,"Is the triple ""Prednisolone affects kidney disorder"" supported by the sentence: ""Effect of prednisolone in the experimentally induced nephropathy in male albino rats.""?",False, +10649036,Prednisolone affects chorioretinitis,316,[On the effect of oral use of prednisolone on central chorioretinitis].,"Is the triple ""Prednisolone affects chorioretinitis"" supported by the sentence: ""[On the effect of oral use of prednisolone on central chorioretinitis].""?",False, +10555139,Prednisolone affects peptic ulcer disease,317,Peptic ulceration associated with prednisolone therapy.,"Is the triple ""Prednisolone affects peptic ulcer disease"" supported by the sentence: ""Peptic ulceration associated with prednisolone therapy.""?",False, +10183156,Prednisolone affects ulcerative colitis,318,"Glucocorticoids (e.g. prednisolone) are cornerstones in the treatment of acute exacerbations of ulcerative colitis (UC), and influence of the leucocyte/endothelial interaction appears to be part of their mode of action.","Is the triple ""Prednisolone affects ulcerative colitis"" supported by the sentence: ""Glucocorticoids (e.g. prednisolone) are cornerstones in the treatment of acute exacerbations of ulcerative colitis (UC), and influence of the leucocyte/endothelial interaction appears to be part of their mode of action.""?",False, +9735520,Prednisolone affects Inflammation,319,"Effects of honey, prednisolone, and disulfiram on inflammation, nitric oxide, and free radical formation.","Is the triple ""Prednisolone affects Inflammation"" supported by the sentence: ""Effects of honey, prednisolone, and disulfiram on inflammation, nitric oxide, and free radical formation.""?",False, +9361682,Prednisolone affects osteoarthritis,320,OBJECTIVE: To assess the treatment effect of sodium hyaluronate (HA) on experimental temporomandibular joint (TMJ) osteoarthritis of rabbits in comparison with prednisolone (PS).,"Is the triple ""Prednisolone affects osteoarthritis"" supported by the sentence: ""OBJECTIVE: To assess the treatment effect of sodium hyaluronate (HA) on experimental temporomandibular joint (TMJ) osteoarthritis of rabbits in comparison with prednisolone (PS).""?",False, +8533593,Prednisolone affects neoplasm,321,"ETO+PSL combination treatment, however, failed to show significant enhancement of anti-tumor effects.","Is the triple ""Prednisolone affects neoplasm"" supported by the sentence: ""ETO+PSL combination treatment, however, failed to show significant enhancement of anti-tumor effects.""?",False, +7800426,Prednisolone affects acute lymphoblastic leukemia,322,"My- and My+ ALL did not significantly differ in sensitivity to prednisolone, dexamethasone, L-asparaginase and cytarabine.","Is the triple ""Prednisolone affects acute lymphoblastic leukemia"" supported by the sentence: ""My- and My+ ALL did not significantly differ in sensitivity to prednisolone, dexamethasone, L-asparaginase and cytarabine.""?",False, +7395227,Prednisolone affects systemic lupus erythematosus,323,"The dose of prednisolone was increased considering he was exacerbated of SLE, however, the convulsion as CNS lupus occurred to him.","Is the triple ""Prednisolone affects systemic lupus erythematosus"" supported by the sentence: ""The dose of prednisolone was increased considering he was exacerbated of SLE, however, the convulsion as CNS lupus occurred to him.""?",False, +21722189,Prednisolone affects Prednisone,324,"In a pilot study using one rabbit, prednisone and prednisolone clearance values increased with increase in either prednisone or prednisolone infusion rates.","Is the triple ""Prednisolone affects Prednisone"" supported by the sentence: ""In a pilot study using one rabbit, prednisone and prednisolone clearance values increased with increase in either prednisone or prednisolone infusion rates.""?",False, +9655099,Prednisolone has input Prednisone,325,"Budesonide is equal to less effective than prednisolone or prednisone therapy in the treatment of active Crohn's disease, but is associated with fewer glucocorticoids adverse reactions.","Is the triple ""Prednisolone has input Prednisone"" supported by the sentence: ""Budesonide is equal to less effective than prednisolone or prednisone therapy in the treatment of active Crohn's disease, but is associated with fewer glucocorticoids adverse reactions.""?",False, +27206106,Prednisolone disrupts uveitis,326,Diclofenac and prednisolone inhibit endotoxin-induced uveitis in rabbits.,"Is the triple ""Prednisolone disrupts uveitis"" supported by the sentence: ""Diclofenac and prednisolone inhibit endotoxin-induced uveitis in rabbits.""?",False, +26515767,Prednisolone disrupts neoplasm,327,"Although prednisolone and GH reverse hypoglycemia by different mechanisms, with only prednisolone suppressing tumor IGF-II secretion, both increase the formation of ternary IGF-IGFBP-3 complexes.","Is the triple ""Prednisolone disrupts neoplasm"" supported by the sentence: ""Although prednisolone and GH reverse hypoglycemia by different mechanisms, with only prednisolone suppressing tumor IGF-II secretion, both increase the formation of ternary IGF-IGFBP-3 complexes.""?",False, +26379811,Prednisolone disrupts contact dermatitis,328,"The aqueous extract of Saiboku-to also showed an inhibition of the contact dermatitis, and it significantly potentiated the inhibition of contact dermatitis by prednisolone.","Is the triple ""Prednisolone disrupts contact dermatitis"" supported by the sentence: ""The aqueous extract of Saiboku-to also showed an inhibition of the contact dermatitis, and it significantly potentiated the inhibition of contact dermatitis by prednisolone.""?",False, +25763558,Prednisolone disrupts pneumonia,329,Only hydrocortisone and prednisolone suppressed LPS pneumonia.,"Is the triple ""Prednisolone disrupts pneumonia"" supported by the sentence: ""Only hydrocortisone and prednisolone suppressed LPS pneumonia.""?",False, +25233555,Prednisolone disrupts allergic disease,330,"Prednisolone significantly inhibited the measurable sensitivity of IDT, while oclacitinib did not.","Is the triple ""Prednisolone disrupts allergic disease"" supported by the sentence: ""Prednisolone significantly inhibited the measurable sensitivity of IDT, while oclacitinib did not.""?",False, +14331279,Prednisolone disrupts hypereosinophilic syndrome,331,"A comparison with the bronchodilator potency of the above drugs indicated that in guinea pigs salbutamol appears relatively selective as a bronchodilator, prednisolone is selective as an inhibitor of eosinophilia whilst theophylline displays a balance of both activities.","Is the triple ""Prednisolone disrupts hypereosinophilic syndrome"" supported by the sentence: ""A comparison with the bronchodilator potency of the above drugs indicated that in guinea pigs salbutamol appears relatively selective as a bronchodilator, prednisolone is selective as an inhibitor of eosinophilia whilst theophylline displays a balance of both activities.""?",False, +10594561,Prednisolone disrupts asthma,332,Reduction of maintenance doses of prednisolone in bronchial asthma by the concurrent use of hydroxyzine.,"Is the triple ""Prednisolone disrupts asthma"" supported by the sentence: ""Reduction of maintenance doses of prednisolone in bronchial asthma by the concurrent use of hydroxyzine.""?",False, +8854473,Prednisolone disrupts Inflammation,333,"In contrast, cyclosporin A (CyA), FK-506 and prednisolone significantly inhibited antigen-induced airway inflammation and BHR in sensitized BN rats.","Is the triple ""Prednisolone disrupts Inflammation"" supported by the sentence: ""In contrast, cyclosporin A (CyA), FK-506 and prednisolone significantly inhibited antigen-induced airway inflammation and BHR in sensitized BN rats.""?",False, +27646185,Prednisolone prevents allergic disease,334,[Use of corticosteroids betamethasone and prednisolone in the prevention of allergic reactions in patients undergoing heart surgery with artificial blood circulation].,"Is the triple ""Prednisolone prevents allergic disease"" supported by the sentence: ""[Use of corticosteroids betamethasone and prednisolone in the prevention of allergic reactions in patients undergoing heart surgery with artificial blood circulation].""?",False, +26227245,Prednisolone prevents synovitis,335,The intra-articular injection of prednisolone was shown to considerably reduce incidence of synovitis.,"Is the triple ""Prednisolone prevents synovitis"" supported by the sentence: ""The intra-articular injection of prednisolone was shown to considerably reduce incidence of synovitis.""?",False, +19453072,Prednisolone prevents hypereosinophilic syndrome,336,"Prednisolone (100 mg/die initially, decreasing doses thereafter) led to significant reduction of infiltrates and eosinophilia.","Is the triple ""Prednisolone prevents hypereosinophilic syndrome"" supported by the sentence: ""Prednisolone (100 mg/die initially, decreasing doses thereafter) led to significant reduction of infiltrates and eosinophilia.""?",False, +16706850,Prednisolone prevents neoplasm,337,The tumour was significantly reduced by prednisolone.,"Is the triple ""Prednisolone prevents neoplasm"" supported by the sentence: ""The tumour was significantly reduced by prednisolone.""?",False, +15809068,Prednisolone prevents colitis,338,"Prednisolone prevented the development of colitis, but had no effect on already-developed colitis.","Is the triple ""Prednisolone prevents colitis"" supported by the sentence: ""Prednisolone prevented the development of colitis, but had no effect on already-developed colitis.""?",False, +11858005,Prednisolone prevents asthma,339,Alveolar NO concentration was increased in patients with refractory asthma (7.1 ppb) compared with mild-to-moderate asthma (3.4 ppb) and normal controls (3.4 ppb) and reduced by treatment with prednisolone.,"Is the triple ""Prednisolone prevents asthma"" supported by the sentence: ""Alveolar NO concentration was increased in patients with refractory asthma (7.1 ppb) compared with mild-to-moderate asthma (3.4 ppb) and normal controls (3.4 ppb) and reduced by treatment with prednisolone.""?",False, +10983909,Prednisolone prevents leprosy,340,"Prednisolone treatment of sensory impairment of the ulnar and posterior tibial nerves detectable with the monofilament test, but not with the ballpen test, did not improve the long-term outcome in terms of recovery of touch sensibility, not did it reduce the risk of leprosy reactions or nerve function impairment beyond the initial 4-month treatment phase.","Is the triple ""Prednisolone prevents leprosy"" supported by the sentence: ""Prednisolone treatment of sensory impairment of the ulnar and posterior tibial nerves detectable with the monofilament test, but not with the ballpen test, did not improve the long-term outcome in terms of recovery of touch sensibility, not did it reduce the risk of leprosy reactions or nerve function impairment beyond the initial 4-month treatment phase.""?",False, +10240036,Prednisolone prevents Inflammation,341,CONCLUSIONS: Predocol is an oral preparation of a poorly absorbed salt of prednisolone that is effective in reducing inflammation over short treatment periods in patients with active ulcerative colitis.,"Is the triple ""Prednisolone prevents Inflammation"" supported by the sentence: ""CONCLUSIONS: Predocol is an oral preparation of a poorly absorbed salt of prednisolone that is effective in reducing inflammation over short treatment periods in patients with active ulcerative colitis.""?",False, +18452194,Prednisolone exacerbates ulcerative colitis,342,"Six weeks prior to his symptoms, prednisolone (PSL) and SASP had been started because of UC aggravation.","Is the triple ""Prednisolone exacerbates ulcerative colitis"" supported by the sentence: ""Six weeks prior to his symptoms, prednisolone (PSL) and SASP had been started because of UC aggravation.""?",False, +25753407,Prednisolone predisposes neoplasm,343,"When comparing organ specific, age-adjusted expected versus observed incidences after natural death of animals an increased tumor risk was found in organ systems of all treatment modalities but prednisolone.","Is the triple ""Prednisolone predisposes neoplasm"" supported by the sentence: ""When comparing organ specific, age-adjusted expected versus observed incidences after natural death of animals an increased tumor risk was found in organ systems of all treatment modalities but prednisolone.""?",False, +16546227,Prednisolone predisposes pneumonia,344,"R-CHOP chemotherapy composed of rituximab, cyclophosphamide, adriamycin, vincristine, and prednisolone which might increase the risk of Pneumocystis pneumonia in patients with non-Hodgkin lymphoma.","Is the triple ""Prednisolone predisposes pneumonia"" supported by the sentence: ""R-CHOP chemotherapy composed of rituximab, cyclophosphamide, adriamycin, vincristine, and prednisolone which might increase the risk of Pneumocystis pneumonia in patients with non-Hodgkin lymphoma.""?",False, +27027571,Hydrocortisone related to HIV infectious disease,345,"Cortisol deficiency is common in late stage HIV disease, but symptoms of fatigue and postural hypotension, as well as biochemical findings, are poor predictors of cortisol deficiency.","Is the triple ""Hydrocortisone related to HIV infectious disease"" supported by the sentence: ""Cortisol deficiency is common in late stage HIV disease, but symptoms of fatigue and postural hypotension, as well as biochemical findings, are poor predictors of cortisol deficiency.""?",False, +25927636,Hydrocortisone related to cardiac arrest,346,[Plasma cortisol and 17-ketosteroids in urine in relation to cardiac arrest].,"Is the triple ""Hydrocortisone related to cardiac arrest"" supported by the sentence: ""[Plasma cortisol and 17-ketosteroids in urine in relation to cardiac arrest].""?",False, +25797574,Hydrocortisone related to lymphoma,347,"Independence of theta and TL surface antigens and killing by thymidine, cortisol, phytohemagglutinin, and cyclic AMP in a murine lymphoma.","Is the triple ""Hydrocortisone related to lymphoma"" supported by the sentence: ""Independence of theta and TL surface antigens and killing by thymidine, cortisol, phytohemagglutinin, and cyclic AMP in a murine lymphoma.""?",False, +25131277,Hydrocortisone related to Crohn disease,348,"Furthermore, this treatment process demonstrated the superior anti-inflammatory effect of prednisolone over that of hydrocortisone and supported the assumption of inflammation related to CD.","Is the triple ""Hydrocortisone related to Crohn disease"" supported by the sentence: ""Furthermore, this treatment process demonstrated the superior anti-inflammatory effect of prednisolone over that of hydrocortisone and supported the assumption of inflammation related to CD.""?",False, +19793698,Hydrocortisone related to alcohol abuse,349,"Ordinary least squared (OLS) regression was used to evaluate whether race moderated the associations between alcohol abuse and four biomarkers-urinary cortisol and serum dehydroepiandrosterone sulfate (DHEA-S), epinephrine and norepinephrine-and two composite summary scores, each consisting of two components that characterize the hypothalamic pituitary adrenal (HPA)-axis and sympathetic nervous systems (SNS), respectively.","Is the triple ""Hydrocortisone related to alcohol abuse"" supported by the sentence: ""Ordinary least squared (OLS) regression was used to evaluate whether race moderated the associations between alcohol abuse and four biomarkers-urinary cortisol and serum dehydroepiandrosterone sulfate (DHEA-S), epinephrine and norepinephrine-and two composite summary scores, each consisting of two components that characterize the hypothalamic pituitary adrenal (HPA)-axis and sympathetic nervous systems (SNS), respectively.""?",False, +19531872,Hydrocortisone related to atrial fibrillation,350,"CONCLUSION: In patients with septic shock, low-dose hydrocortisone was associated with a lower risk of developing AF during the acute phase.","Is the triple ""Hydrocortisone related to atrial fibrillation"" supported by the sentence: ""CONCLUSION: In patients with septic shock, low-dose hydrocortisone was associated with a lower risk of developing AF during the acute phase.""?",False, +18705900,Hydrocortisone related to phobic disorder,351,"The incidence of psychological symptoms as somatization, obsessive-compulsive symptoms, depression, anxiety, phobia, and nonspecific symptoms is statistically increased in pregnant women with elevated morning cortisol, but in women with elevated afternoon cortisol also occurring aggressiveness and paranoia.","Is the triple ""Hydrocortisone related to phobic disorder"" supported by the sentence: ""The incidence of psychological symptoms as somatization, obsessive-compulsive symptoms, depression, anxiety, phobia, and nonspecific symptoms is statistically increased in pregnant women with elevated morning cortisol, but in women with elevated afternoon cortisol also occurring aggressiveness and paranoia.""?",False, +15155784,Hydrocortisone related to psoriasis,352,How stress gets under the skin: cortisol and stress reactivity in psoriasis.,"Is the triple ""Hydrocortisone related to psoriasis"" supported by the sentence: ""How stress gets under the skin: cortisol and stress reactivity in psoriasis.""?",False, +14891361,"Hydrocortisone related to dermatitis, atopic",353,Absorption of hydrocortisone from the skin reservoir in atopic dermatitis.,"Is the triple ""Hydrocortisone related to dermatitis, atopic"" supported by the sentence: ""Absorption of hydrocortisone from the skin reservoir in atopic dermatitis.""?",False, +14483328,Hydrocortisone related to bronchopulmonary dysplasia,354,OBJECTIVE: To assess dexamethasone (DEX) and hydrocortisone (HC) use in premature infants over time and the association of steroid use with the incidence of bronchopulmonary dysplasia (BPD) at 36 weeks' postmenstrual age.,"Is the triple ""Hydrocortisone related to bronchopulmonary dysplasia"" supported by the sentence: ""OBJECTIVE: To assess dexamethasone (DEX) and hydrocortisone (HC) use in premature infants over time and the association of steroid use with the incidence of bronchopulmonary dysplasia (BPD) at 36 weeks' postmenstrual age.""?",False, +14450267,Hydrocortisone related to adrenal cortex neoplasm,355,Increased ratio of mRNA expression of the genes CYP17 and CYP11B1 indicates autonomous cortisol production in adrenocortical tumors.,"Is the triple ""Hydrocortisone related to adrenal cortex neoplasm"" supported by the sentence: ""Increased ratio of mRNA expression of the genes CYP17 and CYP11B1 indicates autonomous cortisol production in adrenocortical tumors.""?",False, +14387016,Hydrocortisone related to cirrhosis of liver,356,"It is concluded that bile acids are potent endogenous inhibitors of 11 beta-HSD and, therefore, could participate in abnormalities of cortisol metabolism observed in liver cirrhosis and extrahepatic biliary obstruction and, possibly, after ingestion of bile acids.","Is the triple ""Hydrocortisone related to cirrhosis of liver"" supported by the sentence: ""It is concluded that bile acids are potent endogenous inhibitors of 11 beta-HSD and, therefore, could participate in abnormalities of cortisol metabolism observed in liver cirrhosis and extrahepatic biliary obstruction and, possibly, after ingestion of bile acids.""?",False, +14360687,Hydrocortisone related to dermatitis,357,"The plasma cortisol concentration was significantly higher in both DD groups before treatment than in the control group, and it decreased significantly after hoof trimming in the trimmed group.","Is the triple ""Hydrocortisone related to dermatitis"" supported by the sentence: ""The plasma cortisol concentration was significantly higher in both DD groups before treatment than in the control group, and it decreased significantly after hoof trimming in the trimmed group.""?",False, +13844584,Hydrocortisone related to acute myeloid leukemia,358,Hydrocortisone in culture protects the blast cells in acute myeloblastic leukemia from the lethal effects of cytosine arabinoside.,"Is the triple ""Hydrocortisone related to acute myeloid leukemia"" supported by the sentence: ""Hydrocortisone in culture protects the blast cells in acute myeloblastic leukemia from the lethal effects of cytosine arabinoside.""?",False, +13213365,Hydrocortisone related to chronic primary adrenal insufficiency,359,Continuous subcutaneous hydrocortisone infusion in Addison's disease.,"Is the triple ""Hydrocortisone related to chronic primary adrenal insufficiency"" supported by the sentence: ""Continuous subcutaneous hydrocortisone infusion in Addison's disease.""?",False, +12756660,Hydrocortisone related to borderline personality disorder,360,The current findings underline the relevance of cortisol and DHEA assessments and the need for further scrutiny of their interplay to foster our understanding of the biological basis of stress regulation in BPD.,"Is the triple ""Hydrocortisone related to borderline personality disorder"" supported by the sentence: ""The current findings underline the relevance of cortisol and DHEA assessments and the need for further scrutiny of their interplay to foster our understanding of the biological basis of stress regulation in BPD.""?",False, +12576998,Hydrocortisone related to Hypoxemia,361,"This hypoxia-specific increase in surface beta-adrenoreceptors was significantly enhanced in the cortisol-treated erythrocytes, showing that cortisol had a significant impact on erythrocyte beta-adrenoreceptor dynamics in addition to the direct influence of hypoxia.","Is the triple ""Hydrocortisone related to Hypoxemia"" supported by the sentence: ""This hypoxia-specific increase in surface beta-adrenoreceptors was significantly enhanced in the cortisol-treated erythrocytes, showing that cortisol had a significant impact on erythrocyte beta-adrenoreceptor dynamics in addition to the direct influence of hypoxia.""?",False, +11888652,Hydrocortisone related to congenital adrenal hyperplasia,362,"Congenital adrenal hyperplasia (CAH) due to deficiency of 21-hydroxylase is a disorder of the adrenal cortex characterised by cortisol deficiency, with or without aldosterone deficiency, and androgen excess.","Is the triple ""Hydrocortisone related to congenital adrenal hyperplasia"" supported by the sentence: ""Congenital adrenal hyperplasia (CAH) due to deficiency of 21-hydroxylase is a disorder of the adrenal cortex characterised by cortisol deficiency, with or without aldosterone deficiency, and androgen excess.""?",False, +11866289,Hydrocortisone related to nicotine dependence,363,"Changes of smoking behavior and serum adrenocorticotropic hormone, cortisol, prolactin, and endogenous opioids levels in nicotine dependence after naltrexone treatment.","Is the triple ""Hydrocortisone related to nicotine dependence"" supported by the sentence: ""Changes of smoking behavior and serum adrenocorticotropic hormone, cortisol, prolactin, and endogenous opioids levels in nicotine dependence after naltrexone treatment.""?",False, +11530989,Hydrocortisone related to pneumonia,364,We hypothesize that hydrocortisone infusion in severe community-acquired pneumonia attenuates systemic inflammation and leads to earlier resolution of pneumonia and a reduction in sepsis-related complications.,"Is the triple ""Hydrocortisone related to pneumonia"" supported by the sentence: ""We hypothesize that hydrocortisone infusion in severe community-acquired pneumonia attenuates systemic inflammation and leads to earlier resolution of pneumonia and a reduction in sepsis-related complications.""?",False, +11442939,Hydrocortisone related to prostate cancer,365,A prospective study was performed to investigate the combination of the aromatase inhibitor aminoglutethimide and hydrocortisone in androgen-independent prostate cancer with changes in prostate-specific antigen (PSA) level as main determinant for response.,"Is the triple ""Hydrocortisone related to prostate cancer"" supported by the sentence: ""A prospective study was performed to investigate the combination of the aromatase inhibitor aminoglutethimide and hydrocortisone in androgen-independent prostate cancer with changes in prostate-specific antigen (PSA) level as main determinant for response.""?",False, +11089023,Hydrocortisone related to pancreatitis,366,"To investigate the time courses of the effects of the exogenous glucocorticoid agonists dexamethasone (DEX) and hydrocortisone (HYD) and a glucocorticoid antagonist (RU-38486), and to characterize the local and systemic responses in experimental AP.","Is the triple ""Hydrocortisone related to pancreatitis"" supported by the sentence: ""To investigate the time courses of the effects of the exogenous glucocorticoid agonists dexamethasone (DEX) and hydrocortisone (HYD) and a glucocorticoid antagonist (RU-38486), and to characterize the local and systemic responses in experimental AP.""?",False, +10649902,Hydrocortisone related to myocardial infarction,367,[The adrenal cortex and hydrocortisone metabolism in experimental myocardial infarct].,"Is the triple ""Hydrocortisone related to myocardial infarction"" supported by the sentence: ""[The adrenal cortex and hydrocortisone metabolism in experimental myocardial infarct].""?",False, +10522181,Hydrocortisone related to osteoarthritis,368,[Intraarticular hydrocortisone (cortril) in arthritis and osteoarthritis].,"Is the triple ""Hydrocortisone related to osteoarthritis"" supported by the sentence: ""[Intraarticular hydrocortisone (cortril) in arthritis and osteoarthritis].""?",False, +10521296,Hydrocortisone related to eye disorder,369,[Use of cortisone and hydrocortisone in eye diseases].,"Is the triple ""Hydrocortisone related to eye disorder"" supported by the sentence: ""[Use of cortisone and hydrocortisone in eye diseases].""?",False, +10518203,Hydrocortisone related to otitis externa,370,[Topical use of hydrocortisone in otitis externa].,"Is the triple ""Hydrocortisone related to otitis externa"" supported by the sentence: ""[Topical use of hydrocortisone in otitis externa].""?",False, +10484611,Hydrocortisone related to ulcerative colitis,371,The use of hydrocortisone in ulcerative colitis: preliminary observations.,"Is the triple ""Hydrocortisone related to ulcerative colitis"" supported by the sentence: ""The use of hydrocortisone in ulcerative colitis: preliminary observations.""?",False, +9718673,Hydrocortisone related to atopic eczema,372,It can therefore be concluded that ointments containing either only E. coli BCS or a combination of BCS and hydrocortisone provide significant relief in perianal eczema as well as in early stages of hemorrhoidal disease.,"Is the triple ""Hydrocortisone related to atopic eczema"" supported by the sentence: ""It can therefore be concluded that ointments containing either only E. coli BCS or a combination of BCS and hydrocortisone provide significant relief in perianal eczema as well as in early stages of hemorrhoidal disease.""?",False, +9492934,Hydrocortisone related to opiate dependence,373,The effect on cortisol supports the above conclusion and is consistent with HPA axis perturbation in opioid dependence as reported in other studies and extends these observations to stable methadone-maintained patients.,"Is the triple ""Hydrocortisone related to opiate dependence"" supported by the sentence: ""The effect on cortisol supports the above conclusion and is consistent with HPA axis perturbation in opioid dependence as reported in other studies and extends these observations to stable methadone-maintained patients.""?",False, +9238280,Hydrocortisone related to Sepsis,374,Several randomized controlled trials have evaluated the efficacy of a replacement therapy with hydrocortisone in severe sepsis.,"Is the triple ""Hydrocortisone related to Sepsis"" supported by the sentence: ""Several randomized controlled trials have evaluated the efficacy of a replacement therapy with hydrocortisone in severe sepsis.""?",False, +9235597,Hydrocortisone related to type 1 diabetes mellitus,375,[Diurnal variations in blood glucose and plasma cortisol in juvenile diabetes mellitus without ketoacidosis].,"Is the triple ""Hydrocortisone related to type 1 diabetes mellitus"" supported by the sentence: ""[Diurnal variations in blood glucose and plasma cortisol in juvenile diabetes mellitus without ketoacidosis].""?",False, +8977987,Hydrocortisone related to injury,376,"OBJECTIVES: Elderly women with proximal femur fracture show abnormal persistence of increased cortisol concentrations, which could contribute to the high morbidity associated with this injury.","Is the triple ""Hydrocortisone related to injury"" supported by the sentence: ""OBJECTIVES: Elderly women with proximal femur fracture show abnormal persistence of increased cortisol concentrations, which could contribute to the high morbidity associated with this injury.""?",False, +8778414,Hydrocortisone related to Inflammation,377,"From the compendium presented above, the following statements become evident: 1) Inappropriately low secretion of cortisol in relation to inflammation is a typical feature of the inflammatory disease in patients with RA.","Is the triple ""Hydrocortisone related to Inflammation"" supported by the sentence: ""From the compendium presented above, the following statements become evident: 1) Inappropriately low secretion of cortisol in relation to inflammation is a typical feature of the inflammatory disease in patients with RA.""?",False, +8763179,Hydrocortisone related to toxic shock syndrome,378,Hydrocortisone infusion in septic shock differentially regulated the cytokine responses.,"Is the triple ""Hydrocortisone related to toxic shock syndrome"" supported by the sentence: ""Hydrocortisone infusion in septic shock differentially regulated the cytokine responses.""?",False, +8625521,Hydrocortisone related to dissociative amnesia,379,"BACKGROUND: There is substantial evidence of dysregulation of cortisol secretion, hippocampal abnormalities, and memory deficits in schizophrenia and other psychotic disorders.","Is the triple ""Hydrocortisone related to dissociative amnesia"" supported by the sentence: ""BACKGROUND: There is substantial evidence of dysregulation of cortisol secretion, hippocampal abnormalities, and memory deficits in schizophrenia and other psychotic disorders.""?",False, +8615164,Hydrocortisone related to asthma,380,(2) One of the mechanisms of therapeutic effect of cortisol in asthma might be its inhibitory effect on CA uptake.,"Is the triple ""Hydrocortisone related to asthma"" supported by the sentence: ""(2) One of the mechanisms of therapeutic effect of cortisol in asthma might be its inhibitory effect on CA uptake.""?",False, +8570630,Hydrocortisone related to fibromyalgia,381,"OBJECTIVE: To compare cortisol levels, diurnal cycles of cortisol, and reactivity of cortisol to psychological stress in fibromyalgia (FM) and rheumatoid arthritis (RA) patients in their natural environment, and to examine the effect on results of accounting for differences among the groups in psychological stress and other lifestyle and psychosocial variables.","Is the triple ""Hydrocortisone related to fibromyalgia"" supported by the sentence: ""OBJECTIVE: To compare cortisol levels, diurnal cycles of cortisol, and reactivity of cortisol to psychological stress in fibromyalgia (FM) and rheumatoid arthritis (RA) patients in their natural environment, and to examine the effect on results of accounting for differences among the groups in psychological stress and other lifestyle and psychosocial variables.""?",False, +8017438,Hydrocortisone related to Insulin resistance,382,"OBJECTIVES: Recent data suggest that higher plasma cortisol may be associated with hypertension and insulin resistance in otherwise healthy men, as it is in Cushing's syndrome.","Is the triple ""Hydrocortisone related to Insulin resistance"" supported by the sentence: ""OBJECTIVES: Recent data suggest that higher plasma cortisol may be associated with hypertension and insulin resistance in otherwise healthy men, as it is in Cushing's syndrome.""?",False, +7919367,Hydrocortisone related to adrenocortical insufficiency,383,"These findings demonstrate 2 types of adrenal insufficiency with different clinical pictures: Type 1 is characterized by cortisol deficiency with hypoglycaemia, low corticoid levels and a low cortisol secretion rate; Type 2 shows aldosterone deficiency with prominent salt loss.","Is the triple ""Hydrocortisone related to adrenocortical insufficiency"" supported by the sentence: ""These findings demonstrate 2 types of adrenal insufficiency with different clinical pictures: Type 1 is characterized by cortisol deficiency with hypoglycaemia, low corticoid levels and a low cortisol secretion rate; Type 2 shows aldosterone deficiency with prominent salt loss.""?",False, +7573954,Hydrocortisone related to neoplasm,384,"November, a period of reproductive quiescence in the southern hemisphere, with new antler growth and rapid weight gain, is associated with higher mean plasma cortisol concentrations and a greater responsiveness to exogenous ACTH.","Is the triple ""Hydrocortisone related to neoplasm"" supported by the sentence: ""November, a period of reproductive quiescence in the southern hemisphere, with new antler growth and rapid weight gain, is associated with higher mean plasma cortisol concentrations and a greater responsiveness to exogenous ACTH.""?",False, +7182905,Hydrocortisone related to obesity disorder,385,Cortisol metabolism in human obesity: impaired cortisone-->cortisol conversion in subjects with central adiposity.,"Is the triple ""Hydrocortisone related to obesity disorder"" supported by the sentence: ""Cortisol metabolism in human obesity: impaired cortisone-->cortisol conversion in subjects with central adiposity.""?",False, +24445107,Hydrocortisone related to Inflammation,386,The hypothalamic-pituitary-adrenal (HPA) axis is one of the key physiological systems that counterbalances this systemic inflammation through changes in adrenocorticotrophic hormone (ACTH) and cortisol.,"Is the triple ""Hydrocortisone related to Inflammation"" supported by the sentence: ""The hypothalamic-pituitary-adrenal (HPA) axis is one of the key physiological systems that counterbalances this systemic inflammation through changes in adrenocorticotrophic hormone (ACTH) and cortisol.""?",False, +24030854,Hydrocortisone related to Hypoxemia,387,"The 5 dpf hypoxic exposure also elicited transient increases in whole body cortisol and in crf, uts1, and hsd20b2 expression, key regulators of the endocrine stress response.","Is the triple ""Hydrocortisone related to Hypoxemia"" supported by the sentence: ""The 5 dpf hypoxic exposure also elicited transient increases in whole body cortisol and in crf, uts1, and hsd20b2 expression, key regulators of the endocrine stress response.""?",False, +12533519,Hydrocortisone related to Insulin resistance,388,"At multiple regression analyses, HOMA-IR on admission in the IR group significantly correlated with thyroid-stimulating hormone, glucagon, and cortisol.","Is the triple ""Hydrocortisone related to Insulin resistance"" supported by the sentence: ""At multiple regression analyses, HOMA-IR on admission in the IR group significantly correlated with thyroid-stimulating hormone, glucagon, and cortisol.""?",False, +27747116,Hydrocortisone causes toxic shock syndrome,389,"The suppression of the anti-inflammatory effects of cortisol as a result of states of excessive stress leads to hypercatabolic diseases such as AIDS, sepsis and toxic shock syndrome and protein calorie malnutrition (NAIDS).","Is the triple ""Hydrocortisone causes toxic shock syndrome"" supported by the sentence: ""The suppression of the anti-inflammatory effects of cortisol as a result of states of excessive stress leads to hypercatabolic diseases such as AIDS, sepsis and toxic shock syndrome and protein calorie malnutrition (NAIDS).""?",False, +27747115,Hydrocortisone causes Sepsis,390,"The suppression of the anti-inflammatory effects of cortisol as a result of states of excessive stress leads to hypercatabolic diseases such as AIDS, sepsis and toxic shock syndrome and protein calorie malnutrition (NAIDS).","Is the triple ""Hydrocortisone causes Sepsis"" supported by the sentence: ""The suppression of the anti-inflammatory effects of cortisol as a result of states of excessive stress leads to hypercatabolic diseases such as AIDS, sepsis and toxic shock syndrome and protein calorie malnutrition (NAIDS).""?",False, +27073884,Hydrocortisone causes atopic eczema,391,"We report the case of a 41-year-old nonatopic women with a previous history of eczematous reaction due to hydrocortisone who suffered worsening of her perennial rhinitis in association with perinasal dermatitis from the use of budesonide in nasal spray form, and stomatitis and pharyngitis due to budesonide in a bronchial inhaler.","Is the triple ""Hydrocortisone causes atopic eczema"" supported by the sentence: ""We report the case of a 41-year-old nonatopic women with a previous history of eczematous reaction due to hydrocortisone who suffered worsening of her perennial rhinitis in association with perinasal dermatitis from the use of budesonide in nasal spray form, and stomatitis and pharyngitis due to budesonide in a bronchial inhaler.""?",False, +25383174,Hydrocortisone causes fibromyalgia,392,"In this perspective paper, we focus on the neuro-endocrine interactions that occur between progesterone, allopregnanolone, and cortisol during pregnancy, and propose that they align with our previously proposed model of FM pathogenesis based on GABAergic ""weakening"" in a thalamocortical neural loop system.","Is the triple ""Hydrocortisone causes fibromyalgia"" supported by the sentence: ""In this perspective paper, we focus on the neuro-endocrine interactions that occur between progesterone, allopregnanolone, and cortisol during pregnancy, and propose that they align with our previously proposed model of FM pathogenesis based on GABAergic ""weakening"" in a thalamocortical neural loop system.""?",False, +25205462,Hydrocortisone causes hypotensive disorder,393,The present study reported a case of hydrocortisone-induced blood pressure reduction in a patient with anterior pituitary hypofunction due to allergic reaction.,"Is the triple ""Hydrocortisone causes hypotensive disorder"" supported by the sentence: ""The present study reported a case of hydrocortisone-induced blood pressure reduction in a patient with anterior pituitary hypofunction due to allergic reaction.""?",False, +20591759,Hydrocortisone causes Hypoxemia,394,Fetal adrenocorticotropic hormone and cortisol increased to peak values within 2.8 hours of induced hypoxia but by 7.2 hours had begun to fall to values that were not significantly different from those at 1.4 hours.,"Is the triple ""Hydrocortisone causes Hypoxemia"" supported by the sentence: ""Fetal adrenocorticotropic hormone and cortisol increased to peak values within 2.8 hours of induced hypoxia but by 7.2 hours had begun to fall to values that were not significantly different from those at 1.4 hours.""?",False, +18446972,Hydrocortisone causes congenital adrenal hyperplasia,395,Congenital adrenal hyperplasia (CAH) is a chronic condition and individuals are exposed to elevated androgen levels in utero as a result of the endogenous cortisol deficiency.,"Is the triple ""Hydrocortisone causes congenital adrenal hyperplasia"" supported by the sentence: ""Congenital adrenal hyperplasia (CAH) is a chronic condition and individuals are exposed to elevated androgen levels in utero as a result of the endogenous cortisol deficiency.""?",False, +18240145,Hydrocortisone causes injury,396,The results of our study confirm that thymol has strong ameliorative effect against hydrocortisone-induced oxidative stress injury in hepatic tissues.,"Is the triple ""Hydrocortisone causes injury"" supported by the sentence: ""The results of our study confirm that thymol has strong ameliorative effect against hydrocortisone-induced oxidative stress injury in hepatic tissues.""?",False, +17359303,Hydrocortisone causes influenza,397,The effects of 8-bromo-cyclic AMP and cyclic AMP agonists (cholera toxin plus hydrocortisone and prostaglandin E2 plus 3-isobutyl-1-methylxanthine) on the cytotoxic activity of T cells generated during murine influenza virus infection have been examined.,"Is the triple ""Hydrocortisone causes influenza"" supported by the sentence: ""The effects of 8-bromo-cyclic AMP and cyclic AMP agonists (cholera toxin plus hydrocortisone and prostaglandin E2 plus 3-isobutyl-1-methylxanthine) on the cytotoxic activity of T cells generated during murine influenza virus infection have been examined.""?",False, +13585273,"Hydrocortisone causes dermatitis, atopic",398,Open oral provocation with 100 or 250 mg hydrocortisone in patients with hydrocortisone contact hypersensitivity elicited cutaneous reactions at sites of previous allergic dermatitis caused by hydrocortisone in two patients and at sites of earlier allergic patch test reactions caused by hydrocortisone in the other two patients.,"Is the triple ""Hydrocortisone causes dermatitis, atopic"" supported by the sentence: ""Open oral provocation with 100 or 250 mg hydrocortisone in patients with hydrocortisone contact hypersensitivity elicited cutaneous reactions at sites of previous allergic dermatitis caused by hydrocortisone in two patients and at sites of earlier allergic patch test reactions caused by hydrocortisone in the other two patients.""?",False, +12645476,Hydrocortisone causes obesity disorder,399,"Although initial studies in transgenic mice and humans are encouraging, more data are required to conclusively prove the hypothesis that the adipose-tissue-specific overexpression of HSD1 and the resultant increase in tissue-specific cortisol concentrations result in human obesity, insulin resistance, high blood pressure, and metabolic syndrome.","Is the triple ""Hydrocortisone causes obesity disorder"" supported by the sentence: ""Although initial studies in transgenic mice and humans are encouraging, more data are required to conclusively prove the hypothesis that the adipose-tissue-specific overexpression of HSD1 and the resultant increase in tissue-specific cortisol concentrations result in human obesity, insulin resistance, high blood pressure, and metabolic syndrome.""?",False, +10068843,Hydrocortisone causes Inflammation,400,"CONCLUSION: Although hydrocortisone has anti-inflammatory properties, it seems to provoke inflammation in the round window membrane after topical instillation.","Is the triple ""Hydrocortisone causes Inflammation"" supported by the sentence: ""CONCLUSION: Although hydrocortisone has anti-inflammatory properties, it seems to provoke inflammation in the round window membrane after topical instillation.""?",False, +9850315,Hydrocortisone causes dissociative amnesia,401,"Type 2 glucocorticoid receptors (GRs), which are occupied by cortisol in humans in times of stress, are thought to be responsible for the glucocorticoid-induced memory impairment.","Is the triple ""Hydrocortisone causes dissociative amnesia"" supported by the sentence: ""Type 2 glucocorticoid receptors (GRs), which are occupied by cortisol in humans in times of stress, are thought to be responsible for the glucocorticoid-induced memory impairment.""?",False, +9318796,Hydrocortisone causes adrenocortical insufficiency,402,"Firstly, the GH-mediated increase in cortisol metabolism (mediated via reduced E to F conversion) may precipitate adrenal insufficiency in hypopituitary patients with partial adrenocorticotropic hormone deficiency commencing GH therapy.","Is the triple ""Hydrocortisone causes adrenocortical insufficiency"" supported by the sentence: ""Firstly, the GH-mediated increase in cortisol metabolism (mediated via reduced E to F conversion) may precipitate adrenal insufficiency in hypopituitary patients with partial adrenocorticotropic hormone deficiency commencing GH therapy.""?",False, +9145908,Hydrocortisone causes otitis externa,403,"From this study it is inferred that the group III steroid betamethasone dipropionate alone heals experimentally induced external otitis more rapidly than hydrocortisone with oxytetracycline, with or without polymyxin B.","Is the triple ""Hydrocortisone causes otitis externa"" supported by the sentence: ""From this study it is inferred that the group III steroid betamethasone dipropionate alone heals experimentally induced external otitis more rapidly than hydrocortisone with oxytetracycline, with or without polymyxin B.""?",False, +8699464,Hydrocortisone causes adrenal cortex neoplasm,404,"In conclusion, the reciprocal expression of CYP17 and the transcriptional repressors COUP-TF and DAX-1 indicates that these orphan receptors have a pathophysiologic role in the excessive hormone production in cortisol- and deoxycorticosterone-producing adrenocortical tumors.","Is the triple ""Hydrocortisone causes adrenal cortex neoplasm"" supported by the sentence: ""In conclusion, the reciprocal expression of CYP17 and the transcriptional repressors COUP-TF and DAX-1 indicates that these orphan receptors have a pathophysiologic role in the excessive hormone production in cortisol- and deoxycorticosterone-producing adrenocortical tumors.""?",False, +8657746,Hydrocortisone causes neoplasm,405,"The administration of hydrocortisone before tumor inoculation resulted in increased tumor take, reduced mean survival time of mice, and concentration of tumor metastasis in a specific organ (i.e., lung metastasis for Ehrlich hypotetraploid clone 1 tumor, and liver metastasis for Ehrlich hypotetraploid stock and Ehrlich hyperdiploid stock tumors).","Is the triple ""Hydrocortisone causes neoplasm"" supported by the sentence: ""The administration of hydrocortisone before tumor inoculation resulted in increased tumor take, reduced mean survival time of mice, and concentration of tumor metastasis in a specific organ (i.e., lung metastasis for Ehrlich hypotetraploid clone 1 tumor, and liver metastasis for Ehrlich hypotetraploid stock and Ehrlich hyperdiploid stock tumors).""?",False, +7929803,Hydrocortisone causes Insulin resistance,406,"Cortisol counteracts the insulin activation of glycogen synthase in muscle, the insulin inhibition of hepatic glucose production and the insulin inhibition of lipolysis in adipose tissue, leading to the well-established systemic insulin resistance caused by excess cortisol.","Is the triple ""Hydrocortisone causes Insulin resistance"" supported by the sentence: ""Cortisol counteracts the insulin activation of glycogen synthase in muscle, the insulin inhibition of hepatic glucose production and the insulin inhibition of lipolysis in adipose tissue, leading to the well-established systemic insulin resistance caused by excess cortisol.""?",False, +7432490,Hydrocortisone causes pancreatitis,407,"The amount of N-acetyl D-glucosamine in the zymogen granule membrane was not altered by caerulein acute pancreatitis induced under continuous hydrocortisone treatment, but it was decreased by the administration of L-364,718 over 7 days after pancreatitis induction.","Is the triple ""Hydrocortisone causes pancreatitis"" supported by the sentence: ""The amount of N-acetyl D-glucosamine in the zymogen granule membrane was not altered by caerulein acute pancreatitis induced under continuous hydrocortisone treatment, but it was decreased by the administration of L-364,718 over 7 days after pancreatitis induction.""?",False, +26997315,Hydrocortisone affects congenital adrenal hyperplasia,408,False elevation of plasma cortisol in congenital adrenal hyperplasia.,"Is the triple ""Hydrocortisone affects congenital adrenal hyperplasia"" supported by the sentence: ""False elevation of plasma cortisol in congenital adrenal hyperplasia.""?",False, +26940919,Hydrocortisone affects cardiac arrest,409,Further studies evaluating the mechanism of action and long term effects of hydrocortisone in cardiac arrest need to be conducted.,"Is the triple ""Hydrocortisone affects cardiac arrest"" supported by the sentence: ""Further studies evaluating the mechanism of action and long term effects of hydrocortisone in cardiac arrest need to be conducted.""?",False, +26840479,Hydrocortisone affects myocardial infarction,410,"In acute MI, there were elevated plasma levels of cortisol depending on the MI severity with a small repeated peak of its increase on day 14 and its subsequent decrease, except deaths.","Is the triple ""Hydrocortisone affects myocardial infarction"" supported by the sentence: ""In acute MI, there were elevated plasma levels of cortisol depending on the MI severity with a small repeated peak of its increase on day 14 and its subsequent decrease, except deaths.""?",False, +24701128,Hydrocortisone affects Sepsis,411,"Aldosterone levels, like cortisol, have been shown to be increased in sepsis and hemorrhagic shock.","Is the triple ""Hydrocortisone affects Sepsis"" supported by the sentence: ""Aldosterone levels, like cortisol, have been shown to be increased in sepsis and hemorrhagic shock.""?",False, +21274202,Hydrocortisone affects osteoarthritis,412,"In this review, we summarize the effects of circadian melatonin, TSH, and cortisol on OA, focusing on how different levels of these hormones affect OA pathogenesis and recovery with respect to the circadian clock.","Is the triple ""Hydrocortisone affects osteoarthritis"" supported by the sentence: ""In this review, we summarize the effects of circadian melatonin, TSH, and cortisol on OA, focusing on how different levels of these hormones affect OA pathogenesis and recovery with respect to the circadian clock.""?",False, +20701310,Hydrocortisone affects psoriasis,413,"There may be a subset of patients unable to elicit an appropriate immunosuppressive response to stress through upregulation of cortisol, with resultant exacerbation of their psoriasis.","Is the triple ""Hydrocortisone affects psoriasis"" supported by the sentence: ""There may be a subset of patients unable to elicit an appropriate immunosuppressive response to stress through upregulation of cortisol, with resultant exacerbation of their psoriasis.""?",False, +20336537,Hydrocortisone affects dermatitis,414,"In addition to local effect, topical hydrocortisone therapy of childhood dermatitis is accompanied by a systemic effect that may be pronounced in the acute phase of disease.","Is the triple ""Hydrocortisone affects dermatitis"" supported by the sentence: ""In addition to local effect, topical hydrocortisone therapy of childhood dermatitis is accompanied by a systemic effect that may be pronounced in the acute phase of disease.""?",False, +20137862,Hydrocortisone affects fibromyalgia,415,"They answered the Fibromyalgia Impact Questionnaire (FIQ), Perceived Stress Questionnaire (PSQ) and McGill Pain Questionnaire (MPQ-Br), and collected saliva to evaluate CC before and after the end of each month.","Is the triple ""Hydrocortisone affects fibromyalgia"" supported by the sentence: ""They answered the Fibromyalgia Impact Questionnaire (FIQ), Perceived Stress Questionnaire (PSQ) and McGill Pain Questionnaire (MPQ-Br), and collected saliva to evaluate CC before and after the end of each month.""?",False, +19555227,Hydrocortisone affects pneumonia,416,"BACKGROUND: The hypothalamic-pituitary-adrenal stress axis plays a crucial role in community-acquired pneumonia (CAP), with high cortisol being associated with disease severity and corticosteroid treatment resulting in earlier time to recovery.","Is the triple ""Hydrocortisone affects pneumonia"" supported by the sentence: ""BACKGROUND: The hypothalamic-pituitary-adrenal stress axis plays a crucial role in community-acquired pneumonia (CAP), with high cortisol being associated with disease severity and corticosteroid treatment resulting in earlier time to recovery.""?",False, +19531871,Hydrocortisone affects atrial fibrillation,417,"The incidence of AF was compared among patients who received hydrocortisone, and the effect of low-dose hydrocortisone on AF was estimated using the inverse probability treatment weighting method based on propensity scores.","Is the triple ""Hydrocortisone affects atrial fibrillation"" supported by the sentence: ""The incidence of AF was compared among patients who received hydrocortisone, and the effect of low-dose hydrocortisone on AF was estimated using the inverse probability treatment weighting method based on propensity scores.""?",False, +18495054,Hydrocortisone affects lymphoma,418,"INTRODUCTION: Intrathecal administration of methotrexate, cytarabine, and hydrocortisone is commonly used to treat and prevent central nervous system involvement in leukemias and lymphomas.","Is the triple ""Hydrocortisone affects lymphoma"" supported by the sentence: ""INTRODUCTION: Intrathecal administration of methotrexate, cytarabine, and hydrocortisone is commonly used to treat and prevent central nervous system involvement in leukemias and lymphomas.""?",False, +18495053,Hydrocortisone affects leukemia,419,"INTRODUCTION: Intrathecal administration of methotrexate, cytarabine, and hydrocortisone is commonly used to treat and prevent central nervous system involvement in leukemias and lymphomas.","Is the triple ""Hydrocortisone affects leukemia"" supported by the sentence: ""INTRODUCTION: Intrathecal administration of methotrexate, cytarabine, and hydrocortisone is commonly used to treat and prevent central nervous system involvement in leukemias and lymphomas.""?",False, +18310128,Hydrocortisone affects toxic shock syndrome,420,"CONCLUSIONS: Early PN did not affect plasma concentrations of ACTH and (free) cortisol, but increased the incidence of septic shock, which statistically explained why more patients on early PN received corticosteroids.","Is the triple ""Hydrocortisone affects toxic shock syndrome"" supported by the sentence: ""CONCLUSIONS: Early PN did not affect plasma concentrations of ACTH and (free) cortisol, but increased the incidence of septic shock, which statistically explained why more patients on early PN received corticosteroids.""?",False, +17910566,Hydrocortisone affects atopic eczema,421,"Sixteen reacted to tixocortol pivalate and also to other corticosteroids, particularly to hydrocortisone, which could explain exacerbations of eczema in these cases.","Is the triple ""Hydrocortisone affects atopic eczema"" supported by the sentence: ""Sixteen reacted to tixocortol pivalate and also to other corticosteroids, particularly to hydrocortisone, which could explain exacerbations of eczema in these cases.""?",False, +15925719,Hydrocortisone affects Inflammation,422,"Finally, transient pre-treatment of healthy humans with cortisol induces a bi-phasic response during a later, delayed systemic inflammatory response: an intermediate cortisol concentration augments inflammation while a high cortisol concentration is neither pro- nor anti-inflammatory.","Is the triple ""Hydrocortisone affects Inflammation"" supported by the sentence: ""Finally, transient pre-treatment of healthy humans with cortisol induces a bi-phasic response during a later, delayed systemic inflammatory response: an intermediate cortisol concentration augments inflammation while a high cortisol concentration is neither pro- nor anti-inflammatory.""?",False, +14970164,Hydrocortisone affects Insulin resistance,423,"Adrenaline induces the early posthypoglycaemic insulin resistance, whereas cortisol and growth hormone are important for the insulin resistance that is observed later following hypoglycaemia.","Is the triple ""Hydrocortisone affects Insulin resistance"" supported by the sentence: ""Adrenaline induces the early posthypoglycaemic insulin resistance, whereas cortisol and growth hormone are important for the insulin resistance that is observed later following hypoglycaemia.""?",False, +14804311,Hydrocortisone affects injury,424,"RESULTS: Within 24 hours following TBI, the concentrations of total cortisol, ACTH and gastrin increased proportionally to the severity of injury, especially significant in the experimental group (P less than 0.05).","Is the triple ""Hydrocortisone affects injury"" supported by the sentence: ""RESULTS: Within 24 hours following TBI, the concentrations of total cortisol, ACTH and gastrin increased proportionally to the severity of injury, especially significant in the experimental group (P less than 0.05).""?",False, +14533429,Hydrocortisone affects hypotensive disorder,425,NEW OR UNIQUE INFORMATION PROVIDED: This case is the first published report of hydrocortisone-responsive hypotension and transient CIRCI associated with naturally occurring septic shock in a dog.,"Is the triple ""Hydrocortisone affects hypotensive disorder"" supported by the sentence: ""NEW OR UNIQUE INFORMATION PROVIDED: This case is the first published report of hydrocortisone-responsive hypotension and transient CIRCI associated with naturally occurring septic shock in a dog.""?",False, +13999195,Hydrocortisone affects congenital adrenal hyperplasia,426,Several types of the congenital adrenal hyperplasias are associated with decreased cortisol production and excessive adrenal sex steroid secretion.,"Is the triple ""Hydrocortisone affects congenital adrenal hyperplasia"" supported by the sentence: ""Several types of the congenital adrenal hyperplasias are associated with decreased cortisol production and excessive adrenal sex steroid secretion.""?",False, +13347553,Hydrocortisone affects asthma,427,[Use of cryo-apheresis in the treatment of patients with cortisol-dependent bronchial asthma].,"Is the triple ""Hydrocortisone affects asthma"" supported by the sentence: ""[Use of cryo-apheresis in the treatment of patients with cortisol-dependent bronchial asthma].""?",False, +13180935,Hydrocortisone affects hypotensive disorder,428,Hypotension after recruitment was reduced by HC (0 vs. 30%).,"Is the triple ""Hydrocortisone affects hypotensive disorder"" supported by the sentence: ""Hypotension after recruitment was reduced by HC (0 vs. 30%).""?",False, +11695335,Hydrocortisone affects Hypoxemia,429,Fetal plasma cortisol concentrations were increased ( P < 0.05) during all levels of hypoxia.,"Is the triple ""Hydrocortisone affects Hypoxemia"" supported by the sentence: ""Fetal plasma cortisol concentrations were increased ( P < 0.05) during all levels of hypoxia.""?",False, +11304252,Hydrocortisone affects obesity disorder,430,"INTRA-CELL CORTISOL: Attention is also focused on the potential implication of cortisol in the genesis of metabolic syndrome, because cortisol is a potent antagonist of the effect of insulin and its presence in excess enhances visceral obesity and insulin resistance.","Is the triple ""Hydrocortisone affects obesity disorder"" supported by the sentence: ""INTRA-CELL CORTISOL: Attention is also focused on the potential implication of cortisol in the genesis of metabolic syndrome, because cortisol is a potent antagonist of the effect of insulin and its presence in excess enhances visceral obesity and insulin resistance.""?",False, +10523644,Hydrocortisone affects injury,431,The effect of hydrocortisone on standardized skin-surface trauma.,"Is the triple ""Hydrocortisone affects injury"" supported by the sentence: ""The effect of hydrocortisone on standardized skin-surface trauma.""?",False, +10431364,Hydrocortisone affects Inflammation,432,The action of hydrocortisone in synovial inflammation.,"Is the triple ""Hydrocortisone affects Inflammation"" supported by the sentence: ""The action of hydrocortisone in synovial inflammation.""?",False, +10074536,Hydrocortisone affects HIV infectious disease,433,"The effects of stressful life events, coping, and cortisol on HIV infection.","Is the triple ""Hydrocortisone affects HIV infectious disease"" supported by the sentence: ""The effects of stressful life events, coping, and cortisol on HIV infection.""?",False, +9872405,Hydrocortisone affects toxic shock syndrome,434,"Immunologic and hemodynamic effects of ""low-dose"" hydrocortisone in septic shock: a double-blind, randomized, placebo-controlled, crossover study.","Is the triple ""Hydrocortisone affects toxic shock syndrome"" supported by the sentence: ""Immunologic and hemodynamic effects of ""low-dose"" hydrocortisone in septic shock: a double-blind, randomized, placebo-controlled, crossover study.""?",False, +9610203,Hydrocortisone affects neoplasm,435,"To prolong the anti-tumor effect some mice were also given cyclophosphamide, hydrocortisone, or a second injection of virus.","Is the triple ""Hydrocortisone affects neoplasm"" supported by the sentence: ""To prolong the anti-tumor effect some mice were also given cyclophosphamide, hydrocortisone, or a second injection of virus.""?",False, +9120606,Hydrocortisone affects asthma,436,"In conclusion, HRT in postmenopausal asthmatic women has a favorable influence on the course of asthma, reduces daily use of glucocorticosteroids and frequency of asthma exacerbations and normalizes serum concentrations of estradiol, cortisol and DHEAS, which were decreased before HRT.","Is the triple ""Hydrocortisone affects asthma"" supported by the sentence: ""In conclusion, HRT in postmenopausal asthmatic women has a favorable influence on the course of asthma, reduces daily use of glucocorticosteroids and frequency of asthma exacerbations and normalizes serum concentrations of estradiol, cortisol and DHEAS, which were decreased before HRT.""?",False, +8017440,Hydrocortisone affects obesity disorder,437,"However, after adjusting for the effect of obesity by multiple regression, higher plasma cortisol was independently associated with higher diastolic blood pressure in men (r = 0.21, P = 0.04) but not in women, and higher fasting serum triglyceride levels in women (r = 0.28, P < 0. 001) but not in men.","Is the triple ""Hydrocortisone affects obesity disorder"" supported by the sentence: ""However, after adjusting for the effect of obesity by multiple regression, higher plasma cortisol was independently associated with higher diastolic blood pressure in men (r = 0.21, P = 0.04) but not in women, and higher fasting serum triglyceride levels in women (r = 0.28, P < 0. 001) but not in men.""?",False, +7974249,Hydrocortisone affects Insulin resistance,438,"ii) Reduction of cortisone to cortisol in the liver may increase insulin resistance in type 2 diabetes mellitus, and inhibition of the enzyme may lead to a decrease in gluconeogenesis.","Is the triple ""Hydrocortisone affects Insulin resistance"" supported by the sentence: ""ii) Reduction of cortisone to cortisol in the liver may increase insulin resistance in type 2 diabetes mellitus, and inhibition of the enzyme may lead to a decrease in gluconeogenesis.""?",False, +7366981,Hydrocortisone affects Hypoxemia,439,"Pretreatment of rats with hydrocortisone or protamin-Zn-insulin within 4 days altered in subsequent acute hypoxia (3 hrs, ""height"" 10 000 m) the isoenzyme spectrum of LDH in lungs, liver tissue and kidney cortex.","Is the triple ""Hydrocortisone affects Hypoxemia"" supported by the sentence: ""Pretreatment of rats with hydrocortisone or protamin-Zn-insulin within 4 days altered in subsequent acute hypoxia (3 hrs, ""height"" 10 000 m) the isoenzyme spectrum of LDH in lungs, liver tissue and kidney cortex.""?",False, +7266667,Hydrocortisone affects dissociative amnesia,440,Previously we related persistent cortisol increases to memory impairments in elderly humans studied over five years.,"Is the triple ""Hydrocortisone affects dissociative amnesia"" supported by the sentence: ""Previously we related persistent cortisol increases to memory impairments in elderly humans studied over five years.""?",False, +27426083,Hydrocortisone produces HIV infectious disease,441,It was suggested that the progressive shift from type 1 to type 2 cytokine production characteristic of HIV infection could be at least partially provoked by the increase in the production of cortisol and the reduction of DHEA.,"Is the triple ""Hydrocortisone produces HIV infectious disease"" supported by the sentence: ""It was suggested that the progressive shift from type 1 to type 2 cytokine production characteristic of HIV infection could be at least partially provoked by the increase in the production of cortisol and the reduction of DHEA.""?",False, +24427531,Hydrocortisone produces cirrhosis of liver,442,CONCLUSIONS: This study suggests that 24 h urinary free cortisol could be considered as a potential index of adrenal cortisol production in patients with liver cirrhosis and it potentially detects patients with a high mortality risk.,"Is the triple ""Hydrocortisone produces cirrhosis of liver"" supported by the sentence: ""CONCLUSIONS: This study suggests that 24 h urinary free cortisol could be considered as a potential index of adrenal cortisol production in patients with liver cirrhosis and it potentially detects patients with a high mortality risk.""?",False, +23738730,Hydrocortisone produces congenital adrenal hyperplasia,443,Congenital adrenal hyperplasia (CAH) is an autosomal recessive disorder that leads to the partial or complete deficiency of cortisol and aldosterone production from the adrenal glands.,"Is the triple ""Hydrocortisone produces congenital adrenal hyperplasia"" supported by the sentence: ""Congenital adrenal hyperplasia (CAH) is an autosomal recessive disorder that leads to the partial or complete deficiency of cortisol and aldosterone production from the adrenal glands.""?",False, +20514012,"Hydrocortisone produces dermatitis, atopic",444,[Reaction of autogenous cortisol production in patients with extensive psoriasis vulgaris or atopic dermatitis following external administration of a 0.25% prednicarbate salve (W/O emulsion)].,"Is the triple ""Hydrocortisone produces dermatitis, atopic"" supported by the sentence: ""[Reaction of autogenous cortisol production in patients with extensive psoriasis vulgaris or atopic dermatitis following external administration of a 0.25% prednicarbate salve (W/O emulsion)].""?",False, +18924640,Hydrocortisone produces Inflammation,445,"OBJECTIVE: Corticosteroid-binding globulin (CBG), the cortisol transport protein, is cleaved from high-affinity (haCBG) to low-affinity (laCBG) CBG at sites of inflammation releasing bioavailable, anti-inflammatory cortisol.","Is the triple ""Hydrocortisone produces Inflammation"" supported by the sentence: ""OBJECTIVE: Corticosteroid-binding globulin (CBG), the cortisol transport protein, is cleaved from high-affinity (haCBG) to low-affinity (laCBG) CBG at sites of inflammation releasing bioavailable, anti-inflammatory cortisol.""?",False, +16473285,Hydrocortisone produces type 1 diabetes mellitus,446,The propensity to develop type 1 diabetes or type 2 diabetes/metabolic syndrome depends on the propensity to release of cortisol which correlates with race.,"Is the triple ""Hydrocortisone produces type 1 diabetes mellitus"" supported by the sentence: ""The propensity to develop type 1 diabetes or type 2 diabetes/metabolic syndrome depends on the propensity to release of cortisol which correlates with race.""?",False, +15760263,Hydrocortisone produces toxic shock syndrome,447,"CIRCI is characterized by an inadequate production of cortisol in relation to an increased demand during periods of severe stress, particularly in critical illnesses such as sepsis or septic shock.","Is the triple ""Hydrocortisone produces toxic shock syndrome"" supported by the sentence: ""CIRCI is characterized by an inadequate production of cortisol in relation to an increased demand during periods of severe stress, particularly in critical illnesses such as sepsis or septic shock.""?",False, +15330155,Hydrocortisone produces chronic primary adrenal insufficiency,448,Synacthen test diagnosed Addison's disease with a clear deficiency of cortisol production.,"Is the triple ""Hydrocortisone produces chronic primary adrenal insufficiency"" supported by the sentence: ""Synacthen test diagnosed Addison's disease with a clear deficiency of cortisol production.""?",False, +14100936,Hydrocortisone produces Insulin resistance,449,"Enhanced cortisol production rates, free cortisol, and 11beta-HSD-1 expression correlate with visceral fat and insulin resistance in men: effect of weight loss.","Is the triple ""Hydrocortisone produces Insulin resistance"" supported by the sentence: ""Enhanced cortisol production rates, free cortisol, and 11beta-HSD-1 expression correlate with visceral fat and insulin resistance in men: effect of weight loss.""?",False, +13891079,Hydrocortisone produces obesity disorder,450,"Obesity is also related to dysregulation of cortisol production by the pre-receptor enzyme, 11beta-hydroxysteroid dehydrogenase, and we speculate that this may have a role in the pathogenesis of obesity and raised ICP seen in IIH.","Is the triple ""Hydrocortisone produces obesity disorder"" supported by the sentence: ""Obesity is also related to dysregulation of cortisol production by the pre-receptor enzyme, 11beta-hydroxysteroid dehydrogenase, and we speculate that this may have a role in the pathogenesis of obesity and raised ICP seen in IIH.""?",False, +13796050,Hydrocortisone produces adrenal cortex neoplasm,451,"This is an extremely rare case of bilateral adrenal tumors, in which the left adrenocortical tumor produced and secreted cortisol or both cortisol and aldosterone and the right one produced and secreted both aldosterone and cortisol, as confirmed by clinical findings and pathological studies using immunohistochemical analysis.","Is the triple ""Hydrocortisone produces adrenal cortex neoplasm"" supported by the sentence: ""This is an extremely rare case of bilateral adrenal tumors, in which the left adrenocortical tumor produced and secreted cortisol or both cortisol and aldosterone and the right one produced and secreted both aldosterone and cortisol, as confirmed by clinical findings and pathological studies using immunohistochemical analysis.""?",False, +13783969,Hydrocortisone produces adrenocortical insufficiency,452,"We conclude that the clinical picture of late-onset adrenal insufficiency in preterm infants is not a result of an absolute deficiency of cortisol production, but may be a result of a limited ability to synthesize sufficient cortisol for the degree of clinical stress.","Is the triple ""Hydrocortisone produces adrenocortical insufficiency"" supported by the sentence: ""We conclude that the clinical picture of late-onset adrenal insufficiency in preterm infants is not a result of an absolute deficiency of cortisol production, but may be a result of a limited ability to synthesize sufficient cortisol for the degree of clinical stress.""?",False, +13669597,Hydrocortisone produces asthma,453,"Ironically, despite our understanding of the various stressors that promote chronic adult-onset asthma, most of which are known to elevate cortisol production via the hypothalamic-pituitary-adrenal (HPA) axis, inhaled and systemic corticosteroids are the mainstay for the treatment of chronic asthma.","Is the triple ""Hydrocortisone produces asthma"" supported by the sentence: ""Ironically, despite our understanding of the various stressors that promote chronic adult-onset asthma, most of which are known to elevate cortisol production via the hypothalamic-pituitary-adrenal (HPA) axis, inhaled and systemic corticosteroids are the mainstay for the treatment of chronic asthma.""?",False, +12147996,Hydrocortisone produces Sepsis,454,Glucocorticoid insufficiency is common during sepsis and may result from insufficient production of cortisol or peripheral tissues resistance.,"Is the triple ""Hydrocortisone produces Sepsis"" supported by the sentence: ""Glucocorticoid insufficiency is common during sepsis and may result from insufficient production of cortisol or peripheral tissues resistance.""?",False, +11989948,Hydrocortisone produces Hypoxemia,455,"This likely represents an adaptive response to LTH, to prevent excessive cortisol production that would restrict fetal growth and potentially induce preterm delivery.","Is the triple ""Hydrocortisone produces Hypoxemia"" supported by the sentence: ""This likely represents an adaptive response to LTH, to prevent excessive cortisol production that would restrict fetal growth and potentially induce preterm delivery.""?",False, +11730055,Hydrocortisone produces pneumonia,456,"The reduction in local cortisol production which diminishes the endogenous anti-inflammatory effects, also allows for the progression of both vascular and pulmonary inflammation.","Is the triple ""Hydrocortisone produces pneumonia"" supported by the sentence: ""The reduction in local cortisol production which diminishes the endogenous anti-inflammatory effects, also allows for the progression of both vascular and pulmonary inflammation.""?",False, +8328567,Hydrocortisone produces prostate cancer,457,"CONCLUSIONS: Patients with newly diagnosed, untreated PC yielded significantly higher cortisol and lower estradiol serum concentrations than controls.","Is the triple ""Hydrocortisone produces prostate cancer"" supported by the sentence: ""CONCLUSIONS: Patients with newly diagnosed, untreated PC yielded significantly higher cortisol and lower estradiol serum concentrations than controls.""?",False, +8077250,Hydrocortisone produces neoplasm,458,"The tumour secreted excessive cortisol and dehydroepiandrosterone-sulphate (DHEA-S), and had invaded the right hepatic lobe and vena cava.","Is the triple ""Hydrocortisone produces neoplasm"" supported by the sentence: ""The tumour secreted excessive cortisol and dehydroepiandrosterone-sulphate (DHEA-S), and had invaded the right hepatic lobe and vena cava.""?",False, +27711985,Hydrocortisone disrupts adrenocortical insufficiency,459,Replacement doses of hydrocortisone were administered throughout treatment to counteract potential adrenal insufficiency secondary to the ketoconazole.,"Is the triple ""Hydrocortisone disrupts adrenocortical insufficiency"" supported by the sentence: ""Replacement doses of hydrocortisone were administered throughout treatment to counteract potential adrenal insufficiency secondary to the ketoconazole.""?",False, +26428860,Hydrocortisone disrupts leukemia,460,Amplication by hydrocortisone of the induction of cytotoxic response in vitro to syngeneic murine leukemias.,"Is the triple ""Hydrocortisone disrupts leukemia"" supported by the sentence: ""Amplication by hydrocortisone of the induction of cytotoxic response in vitro to syngeneic murine leukemias.""?",False, +26389045,Hydrocortisone disrupts neoplasm,461,The results demonstrated that the intrarectal dose of indomethacin and hydrocortisone inhibited the development of tumors from microscopic carcinoma lesions in the large bowel and growing further.,"Is the triple ""Hydrocortisone disrupts neoplasm"" supported by the sentence: ""The results demonstrated that the intrarectal dose of indomethacin and hydrocortisone inhibited the development of tumors from microscopic carcinoma lesions in the large bowel and growing further.""?",False, +26128287,Hydrocortisone disrupts melanoma,462,"Growth of ovarian, lung, breast, and kidney carcinomas was increased by 136%, 126%, 78% and 69%, respectively, whereas melanomas, sarcomas, and colon tumors were inhibited by hydrocortisone.","Is the triple ""Hydrocortisone disrupts melanoma"" supported by the sentence: ""Growth of ovarian, lung, breast, and kidney carcinomas was increased by 136%, 126%, 78% and 69%, respectively, whereas melanomas, sarcomas, and colon tumors were inhibited by hydrocortisone.""?",False, +21020907,Hydrocortisone disrupts pneumonia,463,Insufficient cortisol limits the ability of the sick newborn to handle stress and inhibit pulmonary inflammation.,"Is the triple ""Hydrocortisone disrupts pneumonia"" supported by the sentence: ""Insufficient cortisol limits the ability of the sick newborn to handle stress and inhibit pulmonary inflammation.""?",False, +15895489,Hydrocortisone disrupts obesity disorder,464,"BACKGROUND: Hepatic 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) activity, which converts cortisone (inactive) to cortisol, is downregulated in obesity.","Is the triple ""Hydrocortisone disrupts obesity disorder"" supported by the sentence: ""BACKGROUND: Hepatic 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) activity, which converts cortisone (inactive) to cortisol, is downregulated in obesity.""?",False, +15750557,Hydrocortisone disrupts injury,465,"High-dose hydrocortisone treatment given in the first few hours after a traumatic experience was associated with significant favorable changes in the trajectory of exposure to trauma, as expressed by the reduced risk of the development of PTSD post-trauma.","Is the triple ""Hydrocortisone disrupts injury"" supported by the sentence: ""High-dose hydrocortisone treatment given in the first few hours after a traumatic experience was associated with significant favorable changes in the trajectory of exposure to trauma, as expressed by the reduced risk of the development of PTSD post-trauma.""?",False, +8865955,Hydrocortisone disrupts Inflammation,466,"Under normal conditions, stress induces increased cortisol secretion that counteracts inflammatory reactions.","Is the triple ""Hydrocortisone disrupts Inflammation"" supported by the sentence: ""Under normal conditions, stress induces increased cortisol secretion that counteracts inflammatory reactions.""?",False, +26205555,Hydrocortisone prevents neoplasm,467,Hydrocortisone (HC) reduced the macrophage content of four murine tumors to less than half of control values.,"Is the triple ""Hydrocortisone prevents neoplasm"" supported by the sentence: ""Hydrocortisone (HC) reduced the macrophage content of four murine tumors to less than half of control values.""?",False, +19342068,Hydrocortisone prevents obesity disorder,468,"Further, because infant formula contains only trace amounts of glucocorticoids, these findings suggest that cortisol in milk is a novel biological pathway through which breastfeeding may protect against later obesity.","Is the triple ""Hydrocortisone prevents obesity disorder"" supported by the sentence: ""Further, because infant formula contains only trace amounts of glucocorticoids, these findings suggest that cortisol in milk is a novel biological pathway through which breastfeeding may protect against later obesity.""?",False, +19245686,Hydrocortisone prevents toxic shock syndrome,469,"Conclusions and Relevance: Among adults with severe sepsis not in septic shock, use of hydrocortisone compared with placebo did not reduce the risk of septic shock within 14 days.","Is the triple ""Hydrocortisone prevents toxic shock syndrome"" supported by the sentence: ""Conclusions and Relevance: Among adults with severe sepsis not in septic shock, use of hydrocortisone compared with placebo did not reduce the risk of septic shock within 14 days.""?",False, +18758297,Hydrocortisone prevents injury,470,These findings suggest that HC may protect against hyperoxic injury in the developing pulmonary vasculature.,"Is the triple ""Hydrocortisone prevents injury"" supported by the sentence: ""These findings suggest that HC may protect against hyperoxic injury in the developing pulmonary vasculature.""?",False, +17956690,Hydrocortisone prevents Sepsis,471,OBJECTIVE: Cortisol clearance is reduced in sepsis and may contribute to the development of impaired adrenocortical function that is thought to contribute to the pathophysiology of critical illness-related corticosteroid insufficiency.,"Is the triple ""Hydrocortisone prevents Sepsis"" supported by the sentence: ""OBJECTIVE: Cortisol clearance is reduced in sepsis and may contribute to the development of impaired adrenocortical function that is thought to contribute to the pathophysiology of critical illness-related corticosteroid insufficiency.""?",False, +16963888,Hydrocortisone prevents adrenocortical insufficiency,472,Hydrocortisone therapy was started to prevent adrenal insufficiency before laboratory findings for ACTH (adrenocorticotropic hormone) and cortisol levels.,"Is the triple ""Hydrocortisone prevents adrenocortical insufficiency"" supported by the sentence: ""Hydrocortisone therapy was started to prevent adrenal insufficiency before laboratory findings for ACTH (adrenocorticotropic hormone) and cortisol levels.""?",False, +15550113,Hydrocortisone prevents Inflammation,473,CONCLUSION: We conclude that intravenous stress doses of hydrocortisone lead to a reduction of systemic inflammation and to a potential improvement in the early outcome of patients undergoing off-pump CABG.,"Is the triple ""Hydrocortisone prevents Inflammation"" supported by the sentence: ""CONCLUSION: We conclude that intravenous stress doses of hydrocortisone lead to a reduction of systemic inflammation and to a potential improvement in the early outcome of patients undergoing off-pump CABG.""?",False, +15540854,Hydrocortisone prevents pneumonia,474,"CONCLUSION: In intubated trauma patients, the use of an intravenous stress-dose of hydrocortisone, compared with placebo, resulted in a decreased risk of hospital-acquired pneumonia.","Is the triple ""Hydrocortisone prevents pneumonia"" supported by the sentence: ""CONCLUSION: In intubated trauma patients, the use of an intravenous stress-dose of hydrocortisone, compared with placebo, resulted in a decreased risk of hospital-acquired pneumonia.""?",False, +14020540,Hydrocortisone prevents bronchopulmonary dysplasia,475,"Early hydrocortisone (HC) treatment may decrease the incidence of bronchopulmonary dysplasia; however, the long-term effects are still under evaluation.","Is the triple ""Hydrocortisone prevents bronchopulmonary dysplasia"" supported by the sentence: ""Early hydrocortisone (HC) treatment may decrease the incidence of bronchopulmonary dysplasia; however, the long-term effects are still under evaluation.""?",False, +13075196,Hydrocortisone prevents atrial fibrillation,476,CONCLUSION: Intravenous hydrocortisone reduced the incidence of AF after cardiac surgery.,"Is the triple ""Hydrocortisone prevents atrial fibrillation"" supported by the sentence: ""CONCLUSION: Intravenous hydrocortisone reduced the incidence of AF after cardiac surgery.""?",False, +12187318,Hydrocortisone prevents Insulin resistance,477,"Assuming a single dose of hydrocortisone improves sensitivity of peripheral tissues to insulin, it may be an interesting candidate for use in reducing insulin resistance in peripheral tissues of horses with several disease states.","Is the triple ""Hydrocortisone prevents Insulin resistance"" supported by the sentence: ""Assuming a single dose of hydrocortisone improves sensitivity of peripheral tissues to insulin, it may be an interesting candidate for use in reducing insulin resistance in peripheral tissues of horses with several disease states.""?",False, +14643692,Hydrocortisone exacerbates Sepsis,478,Plasma cortisol and glucagon concentrations were not increased markedly except in a case complicated other systemic bacterial infection.,"Is the triple ""Hydrocortisone exacerbates Sepsis"" supported by the sentence: ""Plasma cortisol and glucagon concentrations were not increased markedly except in a case complicated other systemic bacterial infection.""?",False, +8122784,Hydrocortisone exacerbates obesity disorder,479,"In view of the stimulatory effects of insulin and cortisol on adipogenesis, long-term stimulation of 11betaHSD reductase activity by insulin could aggravate visceral obesity.","Is the triple ""Hydrocortisone exacerbates obesity disorder"" supported by the sentence: ""In view of the stimulatory effects of insulin and cortisol on adipogenesis, long-term stimulation of 11betaHSD reductase activity by insulin could aggravate visceral obesity.""?",False, +25411585,Hydrocortisone predisposes atrial fibrillation,480,"For this purpose, this review article contends that plasma cortisol is linked to a greater risk of AF.","Is the triple ""Hydrocortisone predisposes atrial fibrillation"" supported by the sentence: ""For this purpose, this review article contends that plasma cortisol is linked to a greater risk of AF.""?",False, +19755964,Hydrocortisone predisposes Sepsis,481,"After multivariate analysis, duration of HC stress dose administration was associated with increased risk of mortality (OR 1.11, 95% CI 1.02-1.2, p = 0.021), and total duration of HC treatment was associated with increased risk of sepsis (OR 1.04, 95% CI 1.005-1.075, p = 0.026).","Is the triple ""Hydrocortisone predisposes Sepsis"" supported by the sentence: ""After multivariate analysis, duration of HC stress dose administration was associated with increased risk of mortality (OR 1.11, 95% CI 1.02-1.2, p = 0.021), and total duration of HC treatment was associated with increased risk of sepsis (OR 1.04, 95% CI 1.005-1.075, p = 0.026).""?",False, +13712588,Hydrocortisone predisposes injury,482,"Plasma leptin and ghrelin levels in endotoxin-treated dogs were correlated with serum nitric oxide (r = .955 and r = .890; p < .001), procalcitonin (r = .825 and r = .716; p < .001), cortisol (r = .823 and r = .786; p < .001), and hepatorenal injury markers (r = .580 to .745 and r = .393 to .574; p < .05 to .01).","Is the triple ""Hydrocortisone predisposes injury"" supported by the sentence: ""Plasma leptin and ghrelin levels in endotoxin-treated dogs were correlated with serum nitric oxide (r = .955 and r = .890; p < .001), procalcitonin (r = .825 and r = .716; p < .001), cortisol (r = .823 and r = .786; p < .001), and hepatorenal injury markers (r = .580 to .745 and r = .393 to .574; p < .05 to .01).""?",False, +12555774,Hydrocortisone predisposes toxic shock syndrome,483,Contribution of cortisol deficiency to septic shock.,"Is the triple ""Hydrocortisone predisposes toxic shock syndrome"" supported by the sentence: ""Contribution of cortisol deficiency to septic shock.""?",False, +11782928,Hydrocortisone predisposes Inflammation,484,The objective of this study was to demonstrate the effect of stress doses of hydrocortisone during the initial phase of human septic shock on the serum values of the neurospecific protein S-100B in comparison to the inflammation markers interleukin (IL)-8 in serum and polymorphonuclear (PMN) elastase in plasma.,"Is the triple ""Hydrocortisone predisposes Inflammation"" supported by the sentence: ""The objective of this study was to demonstrate the effect of stress doses of hydrocortisone during the initial phase of human septic shock on the serum values of the neurospecific protein S-100B in comparison to the inflammation markers interleukin (IL)-8 in serum and polymorphonuclear (PMN) elastase in plasma.""?",False, +10520517,Hydrocortisone predisposes obesity disorder,485,"The synergism between insulin and cortisol in stimulating energy deposition, associated with a decreased effect of corticotropin-releasing factor in stimulating energy expenditure, is likely to contribute to the development of obesity.","Is the triple ""Hydrocortisone predisposes obesity disorder"" supported by the sentence: ""The synergism between insulin and cortisol in stimulating energy deposition, associated with a decreased effect of corticotropin-releasing factor in stimulating energy expenditure, is likely to contribute to the development of obesity.""?",False, +8615556,Hydrocortisone predisposes dissociative amnesia,486,Higher basal cortisol predicts verbal memory loss in postmenopausal women: Rancho Bernardo Study.,"Is the triple ""Hydrocortisone predisposes dissociative amnesia"" supported by the sentence: ""Higher basal cortisol predicts verbal memory loss in postmenopausal women: Rancho Bernardo Study.""?",False, +8552834,Hydrocortisone predisposes asthma,487,"A growing body of evidence now suggests that endogenous cortisol, which is produced in significant quantities by the body in a diurnal rhythm, is an important regulator of allergic disease expression and allergic inflammatory responses: lung function varies along with plasma cortisol levels; the number of circulating inflammatory cells varies with plasma cortisol levels; and low levels of endogenous cortisol may be associated with risk for asthma.","Is the triple ""Hydrocortisone predisposes asthma"" supported by the sentence: ""A growing body of evidence now suggests that endogenous cortisol, which is produced in significant quantities by the body in a diurnal rhythm, is an important regulator of allergic disease expression and allergic inflammatory responses: lung function varies along with plasma cortisol levels; the number of circulating inflammatory cells varies with plasma cortisol levels; and low levels of endogenous cortisol may be associated with risk for asthma.""?",False, +8002300,Hydrocortisone predisposes Insulin resistance,488,"In conclusion, the data presented here suggest that cortisol can contribute to insulin resistance in ponies with hyperlipoproteinaemia.","Is the triple ""Hydrocortisone predisposes Insulin resistance"" supported by the sentence: ""In conclusion, the data presented here suggest that cortisol can contribute to insulin resistance in ponies with hyperlipoproteinaemia.""?",False, +7960726,Hydrocortisone predisposes pneumonia,489,"OBJECTIVE: To investigate the relationship of cortisol concentrations during the first week of life to patent ductus arteriosus (PDA), markers of lung inflammation, and respiratory outcome in very low birth weight infants.","Is the triple ""Hydrocortisone predisposes pneumonia"" supported by the sentence: ""OBJECTIVE: To investigate the relationship of cortisol concentrations during the first week of life to patent ductus arteriosus (PDA), markers of lung inflammation, and respiratory outcome in very low birth weight infants.""?",False, +27228384,Methylprednisolone related to Crohn disease,490,Oral pH-modified release budesonide versus 6-methylprednisolone in active Crohn's disease.,"Is the triple ""Methylprednisolone related to Crohn disease"" supported by the sentence: ""Oral pH-modified release budesonide versus 6-methylprednisolone in active Crohn's disease.""?",False, +26974005,Methylprednisolone related to hematopoietic and lymphoid system neoplasm,491,Pharmacokinetics of high dose methylprednisolone and use in hematological malignancies.,"Is the triple ""Methylprednisolone related to hematopoietic and lymphoid system neoplasm"" supported by the sentence: ""Pharmacokinetics of high dose methylprednisolone and use in hematological malignancies.""?",False, +26513818,Methylprednisolone related to B-cell chronic lymphocytic leukemia,492,"Methylprednisolone in advanced chronic lymphocytic leukaemia: rationale for, and effectiveness of treatment suggested by DiSC assay.","Is the triple ""Methylprednisolone related to B-cell chronic lymphocytic leukemia"" supported by the sentence: ""Methylprednisolone in advanced chronic lymphocytic leukaemia: rationale for, and effectiveness of treatment suggested by DiSC assay.""?",False, +26050805,Methylprednisolone related to ankylosing spondylitis,493,The effects of intravenous pulse methylprednisolone on immunological and inflammatory processes in ankylosing spondylitis.,"Is the triple ""Methylprednisolone related to ankylosing spondylitis"" supported by the sentence: ""The effects of intravenous pulse methylprednisolone on immunological and inflammatory processes in ankylosing spondylitis.""?",False, +25845844,Methylprednisolone related to breast neoplasm,494,The effect of methylprednisolone (MP) on the cell kinetic response to cyclophosphamide (CP) and Adriamycin (ADR) in C3H/HeJ spontaneous mammary tumors and hematopoietic tissue was investigated.,"Is the triple ""Methylprednisolone related to breast neoplasm"" supported by the sentence: ""The effect of methylprednisolone (MP) on the cell kinetic response to cyclophosphamide (CP) and Adriamycin (ADR) in C3H/HeJ spontaneous mammary tumors and hematopoietic tissue was investigated.""?",False, +25642837,Methylprednisolone related to dermatomyositis,495,High-dose intravenous methyl-prednisolone in chronic polymyositis/dermatomyositis.,"Is the triple ""Methylprednisolone related to dermatomyositis"" supported by the sentence: ""High-dose intravenous methyl-prednisolone in chronic polymyositis/dermatomyositis.""?",False, +25328503,Methylprednisolone related to Meniere disease,496,Comparing Intratympanic Gentamicin with Methylprednisolone in Meniere's Disease with Non-Serviceable Hearing.,"Is the triple ""Methylprednisolone related to Meniere disease"" supported by the sentence: ""Comparing Intratympanic Gentamicin with Methylprednisolone in Meniere's Disease with Non-Serviceable Hearing.""?",False, +24759961,Methylprednisolone related to non-Hodgkin lymphoma,497,"High-dose methylprednisolone, vincristine, MTX, and ara-C (SOMA) as initial bulk reducing therapy in non-Hodgkin's lymphoma of unfavorable histology: preliminary results of an ongoing phase II study.","Is the triple ""Methylprednisolone related to non-Hodgkin lymphoma"" supported by the sentence: ""High-dose methylprednisolone, vincristine, MTX, and ara-C (SOMA) as initial bulk reducing therapy in non-Hodgkin's lymphoma of unfavorable histology: preliminary results of an ongoing phase II study.""?",False, +24691450,Methylprednisolone related to plantar fasciitis,498,A Prospective Study Comparing the Efficacy of Local Injection of Platelet-Rich Plasma (PRP) vs Methylprednisolone in Plantar Fasciitis.,"Is the triple ""Methylprednisolone related to plantar fasciitis"" supported by the sentence: ""A Prospective Study Comparing the Efficacy of Local Injection of Platelet-Rich Plasma (PRP) vs Methylprednisolone in Plantar Fasciitis.""?",False, +24586108,Methylprednisolone related to alcoholic hepatitis,499,A controlled trial of 6-methylprednisolone in acute alcoholic hepatitis.,"Is the triple ""Methylprednisolone related to alcoholic hepatitis"" supported by the sentence: ""A controlled trial of 6-methylprednisolone in acute alcoholic hepatitis.""?",False, +24559507,Methylprednisolone related to respiratory system disorder,500,[Short-term therapy with methylprednisolone in exacerbated obstructive respiratory tract diseases].,"Is the triple ""Methylprednisolone related to respiratory system disorder"" supported by the sentence: ""[Short-term therapy with methylprednisolone in exacerbated obstructive respiratory tract diseases].""?",False, +23573980,Methylprednisolone related to pneumonia,1,Methylprednisolone and 60 Days in Hospital Survival in Coronavirus Disease 2019 Pneumonia.,"Is the triple ""Methylprednisolone related to pneumonia"" supported by the sentence: ""Methylprednisolone and 60 Days in Hospital Survival in Coronavirus Disease 2019 Pneumonia.""?",False, +23514846,Methylprednisolone related to carpal tunnel syndrome,2,Intra-Carpal Injection of Ozone versus Methylprednisolone in Carpal Tunnel Syndrome of Systemic Sclerosis Patients: A Randomized Single-Blind Clinical Trial.,"Is the triple ""Methylprednisolone related to carpal tunnel syndrome"" supported by the sentence: ""Intra-Carpal Injection of Ozone versus Methylprednisolone in Carpal Tunnel Syndrome of Systemic Sclerosis Patients: A Randomized Single-Blind Clinical Trial.""?",False, +23364897,Methylprednisolone related to West syndrome,3,Methylprednisolone Pulses in West Syndrome: A New Weapon in the Armory-Is it Needed?,"Is the triple ""Methylprednisolone related to West syndrome"" supported by the sentence: ""Methylprednisolone Pulses in West Syndrome: A New Weapon in the Armory-Is it Needed?""?",False, +22495910,Methylprednisolone related to myocarditis,4,Patient underwent treatment with milrinone and methylprednisolone that showed reduction in myocardial inflammation and significantly improved myocardial contractility.,"Is the triple ""Methylprednisolone related to myocarditis"" supported by the sentence: ""Patient underwent treatment with milrinone and methylprednisolone that showed reduction in myocardial inflammation and significantly improved myocardial contractility.""?",False, +22175056,Methylprednisolone related to myopathy,5,"Neurologically, the therapeutic dosages of anticoagulants are linked to the high incidence of thrombotic complexities, while methylprednisolone is associated with myopathy.","Is the triple ""Methylprednisolone related to myopathy"" supported by the sentence: ""Neurologically, the therapeutic dosages of anticoagulants are linked to the high incidence of thrombotic complexities, while methylprednisolone is associated with myopathy.""?",False, +20879022,Methylprednisolone related to Pain,6,"Conclusion: Based on the current data, the efficacy and safety of local injection of triamcinolone and methylprednisolone at doses of 20 and 40 mg were associated with a significant improvement in pain, functional status, and strength.","Is the triple ""Methylprednisolone related to Pain"" supported by the sentence: ""Conclusion: Based on the current data, the efficacy and safety of local injection of triamcinolone and methylprednisolone at doses of 20 and 40 mg were associated with a significant improvement in pain, functional status, and strength.""?",False, +20342058,Methylprednisolone related to chronic progressive multiple sclerosis,7,OBJECTIVE: To validate the responsiveness of cerebrospinal fluid (CSF) inflammatory biomarkers to treatment with natalizumab and methylprednisolone in progressive MS and to examine the relationship between CSF inflammatory and tissue damage biomarkers.,"Is the triple ""Methylprednisolone related to chronic progressive multiple sclerosis"" supported by the sentence: ""OBJECTIVE: To validate the responsiveness of cerebrospinal fluid (CSF) inflammatory biomarkers to treatment with natalizumab and methylprednisolone in progressive MS and to examine the relationship between CSF inflammatory and tissue damage biomarkers.""?",False, +20290784,Methylprednisolone related to membranous glomerulonephritis,8,The region was identified as a significant predictor of use of intravenous methylprednisolone in MCD and MN patients.,"Is the triple ""Methylprednisolone related to membranous glomerulonephritis"" supported by the sentence: ""The region was identified as a significant predictor of use of intravenous methylprednisolone in MCD and MN patients.""?",False, +20286711,Methylprednisolone related to neuromyelitis optica,9,"Clinical commentary on ""Two cases of anaphylactic shock by methylprednisolone in neuromyelitis optica"".","Is the triple ""Methylprednisolone related to neuromyelitis optica"" supported by the sentence: ""Clinical commentary on ""Two cases of anaphylactic shock by methylprednisolone in neuromyelitis optica"".""?",False, +19340184,Methylprednisolone related to chronic obstructive pulmonary disease,10,CONCLUSION: Results show that inhalation of budesonide (2 mg 3 times/day) and systemic methylprednisolone (40 mg/day) had similar clinical outcome in AECOPD.,"Is the triple ""Methylprednisolone related to chronic obstructive pulmonary disease"" supported by the sentence: ""CONCLUSION: Results show that inhalation of budesonide (2 mg 3 times/day) and systemic methylprednisolone (40 mg/day) had similar clinical outcome in AECOPD.""?",False, +18938435,Methylprednisolone related to graft versus host disease,11,A Clinical Trial Comparing the Safety and Efficacy of Topical Tacrolimus versus Methylprednisolone in Ocular Graft-versus-Host Disease.,"Is the triple ""Methylprednisolone related to graft versus host disease"" supported by the sentence: ""A Clinical Trial Comparing the Safety and Efficacy of Topical Tacrolimus versus Methylprednisolone in Ocular Graft-versus-Host Disease.""?",False, +17333962,Methylprednisolone related to Inflammation,12,The purpose of this study was to evaluate the efficacy of supraperiosteal injection of methylprednisolone compared with an oral tablet form and intravenous (i.v.) injection in the prevention of postoperative pain and oedema associated with inflammation.,"Is the triple ""Methylprednisolone related to Inflammation"" supported by the sentence: ""The purpose of this study was to evaluate the efficacy of supraperiosteal injection of methylprednisolone compared with an oral tablet form and intravenous (i.v.) injection in the prevention of postoperative pain and oedema associated with inflammation.""?",False, +17288506,Methylprednisolone related to autoimmune thrombocytopenic purpura,13,Gamma globulin and methylprednisolone in idiopathic thrombocytopenic purpura.,"Is the triple ""Methylprednisolone related to autoimmune thrombocytopenic purpura"" supported by the sentence: ""Gamma globulin and methylprednisolone in idiopathic thrombocytopenic purpura.""?",False, +15936572,Methylprednisolone related to endocrine exophthalmos,14,Methylprednisolone and hepatotoxicity in Graves' ophthalmopathy.,"Is the triple ""Methylprednisolone related to endocrine exophthalmos"" supported by the sentence: ""Methylprednisolone and hepatotoxicity in Graves' ophthalmopathy.""?",False, +15072844,Methylprednisolone related to Edema,15,"In orthognathic surgery, methylprednisolone > or =85 mg administered intravenously seemed sufficient to produce a significant decrease in edema, and several trials pointed toward a neuroregeneration effect, but no statistical analysis could be performed.","Is the triple ""Methylprednisolone related to Edema"" supported by the sentence: ""In orthognathic surgery, methylprednisolone > or =85 mg administered intravenously seemed sufficient to produce a significant decrease in edema, and several trials pointed toward a neuroregeneration effect, but no statistical analysis could be performed.""?",False, +14876749,Methylprednisolone related to osteoarthritis,16,Response of symptoms and synovitis to intra-muscular methylprednisolone in osteoarthritis of the hand: an ultrasonographic study.,"Is the triple ""Methylprednisolone related to osteoarthritis"" supported by the sentence: ""Response of symptoms and synovitis to intra-muscular methylprednisolone in osteoarthritis of the hand: an ultrasonographic study.""?",False, +14399082,Methylprednisolone related to aplastic anemia,17,Long-term results of high-dose methylprednisolone in aplastic anemia.,"Is the triple ""Methylprednisolone related to aplastic anemia"" supported by the sentence: ""Long-term results of high-dose methylprednisolone in aplastic anemia.""?",False, +14398237,Methylprednisolone related to IgA glomerulonephritis,18,"Efficacy of methylprednisolone, cyclophosphamide in pediatric IgA nephropathy assessed by renal biopsy.","Is the triple ""Methylprednisolone related to IgA glomerulonephritis"" supported by the sentence: ""Efficacy of methylprednisolone, cyclophosphamide in pediatric IgA nephropathy assessed by renal biopsy.""?",False, +14278238,"Methylprednisolone related to dermatitis, atopic",19,"The impaired effect on lymphocyte blastogenesis of glucocorticoids administered in vivo, in contrast to a normal in vitro reaction to dexamethasone, together with recent findings of an altered glucocorticoid receptor pharmacology in AD, points to a decreased biological in vivo efficiency of methylprednisolone in atopic dermatitis.","Is the triple ""Methylprednisolone related to dermatitis, atopic"" supported by the sentence: ""The impaired effect on lymphocyte blastogenesis of glucocorticoids administered in vivo, in contrast to a normal in vitro reaction to dexamethasone, together with recent findings of an altered glucocorticoid receptor pharmacology in AD, points to a decreased biological in vivo efficiency of methylprednisolone in atopic dermatitis.""?",False, +14166179,Methylprednisolone related to cardiac arrest,20,"CONCLUSION: In this single-center trial, combined vasopressin-epinephrine and methylprednisolone during resuscitation and stress-dose hydrocortisone in postresuscitation shock improved survival in refractory in-hospital cardiac arrest.","Is the triple ""Methylprednisolone related to cardiac arrest"" supported by the sentence: ""CONCLUSION: In this single-center trial, combined vasopressin-epinephrine and methylprednisolone during resuscitation and stress-dose hydrocortisone in postresuscitation shock improved survival in refractory in-hospital cardiac arrest.""?",False, +12755316,Methylprednisolone related to plasma cell myeloma,21,Weekly bortezomib/methylprednisolone is effective and well tolerated in relapsed multiple myeloma.,"Is the triple ""Methylprednisolone related to plasma cell myeloma"" supported by the sentence: ""Weekly bortezomib/methylprednisolone is effective and well tolerated in relapsed multiple myeloma.""?",False, +12183687,Methylprednisolone related to acute lymphoblastic leukemia,22,Amsacrine combined with etoposide and high-dose methylprednisolone as salvage therapy in acute lymphoblastic leukemia in children.,"Is the triple ""Methylprednisolone related to acute lymphoblastic leukemia"" supported by the sentence: ""Amsacrine combined with etoposide and high-dose methylprednisolone as salvage therapy in acute lymphoblastic leukemia in children.""?",False, +11720471,Methylprednisolone related to systemic lupus erythematosus,23,Controlled clinical trial of IV cyclophosphamide versus IV methylprednisolone in severe neurological manifestations in systemic lupus erythematosus.,"Is the triple ""Methylprednisolone related to systemic lupus erythematosus"" supported by the sentence: ""Controlled clinical trial of IV cyclophosphamide versus IV methylprednisolone in severe neurological manifestations in systemic lupus erythematosus.""?",False, +10812685,Methylprednisolone related to immunoglobulin a vasculitis,24,Delayed hypersensitivity to 6-methyl-prednisolone in Henoch Schoenlein syndrome.,"Is the triple ""Methylprednisolone related to immunoglobulin a vasculitis"" supported by the sentence: ""Delayed hypersensitivity to 6-methyl-prednisolone in Henoch Schoenlein syndrome.""?",False, +10763477,Methylprednisolone related to ulcerative colitis,25,Rectal absorption of radioactive 6-alpha-methyl prednisolone in ulcerative colitis.,"Is the triple ""Methylprednisolone related to ulcerative colitis"" supported by the sentence: ""Rectal absorption of radioactive 6-alpha-methyl prednisolone in ulcerative colitis.""?",False, +10558884,Methylprednisolone related to lupus nephritis,26,Controlled trial of pulse methylprednisolone versus two regimens of pulse cyclophosphamide in severe lupus nephritis.,"Is the triple ""Methylprednisolone related to lupus nephritis"" supported by the sentence: ""Controlled trial of pulse methylprednisolone versus two regimens of pulse cyclophosphamide in severe lupus nephritis.""?",False, +10130342,Methylprednisolone related to adult acute respiratory distress syndrome,27,"The National Heart, Lung, and Blood Institute's ARDS Network currently is testing the use of methylprednisolone in late ARDS.","Is the triple ""Methylprednisolone related to adult acute respiratory distress syndrome"" supported by the sentence: ""The National Heart, Lung, and Blood Institute's ARDS Network currently is testing the use of methylprednisolone in late ARDS.""?",False, +9229208,Methylprednisolone related to vestibular neuronitis,28,"(3) Preliminary results of an interim analysis from an ongoing randomized, prospective study showed that methylprednisolone (plus an antiviral agent?) may be useful for improving peripheral vestibular function in vestibular neuritis.","Is the triple ""Methylprednisolone related to vestibular neuronitis"" supported by the sentence: ""(3) Preliminary results of an interim analysis from an ongoing randomized, prospective study showed that methylprednisolone (plus an antiviral agent?) may be useful for improving peripheral vestibular function in vestibular neuritis.""?",False, +9003326,Methylprednisolone related to systemic sclerosis,29,This is the first report of cyclophosphamide and methylprednisolone leading to complete and sustained resolution of GAVE in association with systemic sclerosis.,"Is the triple ""Methylprednisolone related to systemic sclerosis"" supported by the sentence: ""This is the first report of cyclophosphamide and methylprednisolone leading to complete and sustained resolution of GAVE in association with systemic sclerosis.""?",False, +8447481,Methylprednisolone related to rheumatoid arthritis,30,We compared lymphocyte-suppressive potencies of prednisolone and methylprednisolone in rheumatoid arthritis (RA).,"Is the triple ""Methylprednisolone related to rheumatoid arthritis"" supported by the sentence: ""We compared lymphocyte-suppressive potencies of prednisolone and methylprednisolone in rheumatoid arthritis (RA).""?",False, +8282330,Methylprednisolone related to spinal cord injury,31,"Despite the lucrative ""off label"" markets for methylprednisolone in SCI, no Food and Drug Association indication has been obtained.","Is the triple ""Methylprednisolone related to spinal cord injury"" supported by the sentence: ""Despite the lucrative ""off label"" markets for methylprednisolone in SCI, no Food and Drug Association indication has been obtained.""?",False, +7944646,Methylprednisolone related to myasthenia gravis,32,Extraocular muscle responses to high dose intravenous methylprednisolone in myasthenia gravis.,"Is the triple ""Methylprednisolone related to myasthenia gravis"" supported by the sentence: ""Extraocular muscle responses to high dose intravenous methylprednisolone in myasthenia gravis.""?",False, +7668599,Methylprednisolone related to multiple sclerosis,33,The increased CSF levels of TNF-sRp55 in response to MP circumstantially suggest that this receptor could partially account for the beneficial effects of MP in acute MS.,"Is the triple ""Methylprednisolone related to multiple sclerosis"" supported by the sentence: ""The increased CSF levels of TNF-sRp55 in response to MP circumstantially suggest that this receptor could partially account for the beneficial effects of MP in acute MS.""?",False, +7443745,Methylprednisolone related to asthma,34,"Such an effect has been demonstrated between clarithromycin and methylprednisolone, two drugs that may be administered concomitantly in asthma.","Is the triple ""Methylprednisolone related to asthma"" supported by the sentence: ""Such an effect has been demonstrated between clarithromycin and methylprednisolone, two drugs that may be administered concomitantly in asthma.""?",False, +24973247,Methylprednisolone causes lupus nephritis,35,"In this study, low-dose methylprednisolone (0.8 mg/kg/day, MP) was used to induce a steroid-resistant lupus nephritis (SR-LN) mouse model in weeks one to four, and a therapeutic steroid dosage (MP 12 mg/kg/day) or a combined PNS (PNS 100 mg/kg/day) treatment was administered from week five to eight.","Is the triple ""Methylprednisolone causes lupus nephritis"" supported by the sentence: ""In this study, low-dose methylprednisolone (0.8 mg/kg/day, MP) was used to induce a steroid-resistant lupus nephritis (SR-LN) mouse model in weeks one to four, and a therapeutic steroid dosage (MP 12 mg/kg/day) or a combined PNS (PNS 100 mg/kg/day) treatment was administered from week five to eight.""?",False, +24161886,Methylprednisolone causes Edema,36,MP was administrated in three alternative ways: intraperitoneally during the induction of cytotoxic edema or immediately after finishing cytotoxic edema induction in a dose of 100 mg/kg b.w.; into the internal carotid artery within 2 h after finishing cytotoxic edema induction in a dose of 50 mg/kg b.w.; into internal carotid artery 10 min after edema induction by BBBd in a dose of 50 mg/kg b.w.,"Is the triple ""Methylprednisolone causes Edema"" supported by the sentence: ""MP was administrated in three alternative ways: intraperitoneally during the induction of cytotoxic edema or immediately after finishing cytotoxic edema induction in a dose of 100 mg/kg b.w.; into the internal carotid artery within 2 h after finishing cytotoxic edema induction in a dose of 50 mg/kg b.w.; into internal carotid artery 10 min after edema induction by BBBd in a dose of 50 mg/kg b.w.""?",False, +18534953,Methylprednisolone causes Inflammation,37,"On the other hand, daily administration of methylprednisolone and tenoxicam for 4 weeks caused increased inflammation and fibrosis and wasn't affective on protection of nerve physiomorphology.","Is the triple ""Methylprednisolone causes Inflammation"" supported by the sentence: ""On the other hand, daily administration of methylprednisolone and tenoxicam for 4 weeks caused increased inflammation and fibrosis and wasn't affective on protection of nerve physiomorphology.""?",False, +18260665,Methylprednisolone causes neoplasm,38,Methylprednisolone was temporarily stopped while a broad work up for inflammatory and neoplastic causes was pursued.,"Is the triple ""Methylprednisolone causes neoplasm"" supported by the sentence: ""Methylprednisolone was temporarily stopped while a broad work up for inflammatory and neoplastic causes was pursued.""?",False, +17307095,Methylprednisolone causes pneumonia,39,"Pneumocystis pneumonia induced by this dose of tacrolimus has been reported in many cases; however, we encountered a rare case of Pneumocystis pneumonia induced by low-dose tacrolimus and methylprednisolone.","Is the triple ""Methylprednisolone causes pneumonia"" supported by the sentence: ""Pneumocystis pneumonia induced by this dose of tacrolimus has been reported in many cases; however, we encountered a rare case of Pneumocystis pneumonia induced by low-dose tacrolimus and methylprednisolone.""?",False, +15906641,Methylprednisolone causes Pain,40,The increased interval in the administration of MP resulted in slightly greater pain and an increased prevalence of NeP.,"Is the triple ""Methylprednisolone causes Pain"" supported by the sentence: ""The increased interval in the administration of MP resulted in slightly greater pain and an increased prevalence of NeP.""?",False, +13166073,Methylprednisolone causes thrombocytopenia,41,"We describe that high-dose methylprednisolone (20 mg/kg) can induce multifocal osteonecrosis (ON) in conjunction with thrombocytopenia, hypofibrinogenemia, and hyperlipemia.","Is the triple ""Methylprednisolone causes thrombocytopenia"" supported by the sentence: ""We describe that high-dose methylprednisolone (20 mg/kg) can induce multifocal osteonecrosis (ON) in conjunction with thrombocytopenia, hypofibrinogenemia, and hyperlipemia.""?",False, +12672767,Methylprednisolone causes drug-induced liver injury,42,"OBJECTIVE: To report the third published case, as of April 8, 2006, of methylprednisolone-induced toxic hepatitis.","Is the triple ""Methylprednisolone causes drug-induced liver injury"" supported by the sentence: ""OBJECTIVE: To report the third published case, as of April 8, 2006, of methylprednisolone-induced toxic hepatitis.""?",False, +8525599,Methylprednisolone causes myopathy,43,"To our knowledge, this is the first discussion considering the possibility that the methylprednisolone recommended by NASCIS may cause acute corticosteroid myopathy.","Is the triple ""Methylprednisolone causes myopathy"" supported by the sentence: ""To our knowledge, this is the first discussion considering the possibility that the methylprednisolone recommended by NASCIS may cause acute corticosteroid myopathy.""?",False, +27357949,Methylprednisolone affects neoplasm,44,"However, high-dose steroids like dexamethasone or methylprednisolone had proven their clearcut anti-tumoral action.","Is the triple ""Methylprednisolone affects neoplasm"" supported by the sentence: ""However, high-dose steroids like dexamethasone or methylprednisolone had proven their clearcut anti-tumoral action.""?",False, +24420470,Methylprednisolone affects Inflammation,45,"Methylprednisolone increases some astrogliosis and inflammation biomarkers' levels; however, it did not affect the apoptotic biomarkers.","Is the triple ""Methylprednisolone affects Inflammation"" supported by the sentence: ""Methylprednisolone increases some astrogliosis and inflammation biomarkers' levels; however, it did not affect the apoptotic biomarkers.""?",False, +23472756,Methylprednisolone affects Inflammation,46,Effect of Methylprednisolone on Inflammation and Coagulation in Patients with Severe COVID-19: A Retrospective Cohort Study.,"Is the triple ""Methylprednisolone affects Inflammation"" supported by the sentence: ""Effect of Methylprednisolone on Inflammation and Coagulation in Patients with Severe COVID-19: A Retrospective Cohort Study.""?",False, +20530617,Methylprednisolone affects systemic sclerosis,47,"METHODS/DESIGN: This study is a 12-week, randomised, double-blind, placebo-controlled trial analysing the effects of high-dose intravenous methylprednisolone in very early SSc.","Is the triple ""Methylprednisolone affects systemic sclerosis"" supported by the sentence: ""METHODS/DESIGN: This study is a 12-week, randomised, double-blind, placebo-controlled trial analysing the effects of high-dose intravenous methylprednisolone in very early SSc.""?",False, +20254789,Methylprednisolone affects adult acute respiratory distress syndrome,48,"Methods: The potential interferences Se@SiO2 nanocomposites may have to the therapeutic effect of methylprednisolone (MPS) were evaluated by classical therapeutic effect index of acute respiratory distress syndrome (ARDS), such as wet-to-dry weight ratio, inflammatory factors IL-1beta and TNF-alpha.","Is the triple ""Methylprednisolone affects adult acute respiratory distress syndrome"" supported by the sentence: ""Methods: The potential interferences Se@SiO2 nanocomposites may have to the therapeutic effect of methylprednisolone (MPS) were evaluated by classical therapeutic effect index of acute respiratory distress syndrome (ARDS), such as wet-to-dry weight ratio, inflammatory factors IL-1beta and TNF-alpha.""?",False, +17649050,Methylprednisolone affects optic nerve disorder,49,Our case likely represents worsening of DON due to soft tissue swelling secondary to OR despite cover with IVMP in a patient previously responsive to IVMP alone.,"Is the triple ""Methylprednisolone affects optic nerve disorder"" supported by the sentence: ""Our case likely represents worsening of DON due to soft tissue swelling secondary to OR despite cover with IVMP in a patient previously responsive to IVMP alone.""?",False, +16634377,Methylprednisolone affects myasthenia gravis,50,[Treatment of invasive thymoma with myasthenia gravis: a case report responsive to azathioprine and methylprednisolone].,"Is the triple ""Methylprednisolone affects myasthenia gravis"" supported by the sentence: ""[Treatment of invasive thymoma with myasthenia gravis: a case report responsive to azathioprine and methylprednisolone].""?",False, +16277488,Methylprednisolone affects neuromyelitis optica,51,High-dose intravenous methylprednisolone is the first-line therapy for acute exacerbations of NMO.,"Is the triple ""Methylprednisolone affects neuromyelitis optica"" supported by the sentence: ""High-dose intravenous methylprednisolone is the first-line therapy for acute exacerbations of NMO.""?",False, +15906642,Methylprednisolone affects Pain,52,"CONCLUSION: Although the delayed administration of high-dose MP did not significantly increase the severity of pain or prevalence of NeP, it should still be avoided due to the increased risk of serious side effects.","Is the triple ""Methylprednisolone affects Pain"" supported by the sentence: ""CONCLUSION: Although the delayed administration of high-dose MP did not significantly increase the severity of pain or prevalence of NeP, it should still be avoided due to the increased risk of serious side effects.""?",False, +15610554,Methylprednisolone affects rheumatoid arthritis,53,Methylprednisolone has been used in other Th1 mediated diseases such as rheumatoid arthritis in an attempt to switch off the immune response and so we investigated the efficacy of three days of high dose (1 g) intravenous methylprednisolone at the start of prednisolone therapy in leprosy Type 1 reactions and nerve function impairment.,"Is the triple ""Methylprednisolone affects rheumatoid arthritis"" supported by the sentence: ""Methylprednisolone has been used in other Th1 mediated diseases such as rheumatoid arthritis in an attempt to switch off the immune response and so we investigated the efficacy of three days of high dose (1 g) intravenous methylprednisolone at the start of prednisolone therapy in leprosy Type 1 reactions and nerve function impairment.""?",False, +15186368,Methylprednisolone affects graft versus host disease,54,Myelitis in these patients was not related to graft versus host disease or immune reconstitution and was responsive to intravenous methylprednisolone and cyclophosphamide.,"Is the triple ""Methylprednisolone affects graft versus host disease"" supported by the sentence: ""Myelitis in these patients was not related to graft versus host disease or immune reconstitution and was responsive to intravenous methylprednisolone and cyclophosphamide.""?",False, +14891106,Methylprednisolone affects kidney disorder,55,"We investigated the effects of YM264, WEB2086, methylprednisolone and ticlopidine on puromycin-induced nephropathy in the rat.","Is the triple ""Methylprednisolone affects kidney disorder"" supported by the sentence: ""We investigated the effects of YM264, WEB2086, methylprednisolone and ticlopidine on puromycin-induced nephropathy in the rat.""?",False, +11819955,Methylprednisolone affects spinal cord injury,56,"The study strongly suggests that methylprednisolone has significant beneficial effects in human spinal cord injury, that these effects occur only when the drug is given within 8 hr, and that it helps even in patients with severe spinal cord injuries.","Is the triple ""Methylprednisolone affects spinal cord injury"" supported by the sentence: ""The study strongly suggests that methylprednisolone has significant beneficial effects in human spinal cord injury, that these effects occur only when the drug is given within 8 hr, and that it helps even in patients with severe spinal cord injuries.""?",False, +10845505,Methylprednisolone affects Pain,57,"Comparison of the effects of 2 doses of methylprednisolone on pain, swelling, and trismus after third molar surgery.","Is the triple ""Methylprednisolone affects Pain"" supported by the sentence: ""Comparison of the effects of 2 doses of methylprednisolone on pain, swelling, and trismus after third molar surgery.""?",False, +10048898,Methylprednisolone affects ulcerative colitis,58,Steatohepatitis during methylprednisolone therapy for ulcerative colitis exacerbation.,"Is the triple ""Methylprednisolone affects ulcerative colitis"" supported by the sentence: ""Steatohepatitis during methylprednisolone therapy for ulcerative colitis exacerbation.""?",False, +9646753,Methylprednisolone affects multiple sclerosis,59,These results suggest that increasing the uric acid concentration may represent one of the possible mechanisms of action of methylprednisolone in multiple sclerosis.,"Is the triple ""Methylprednisolone affects multiple sclerosis"" supported by the sentence: ""These results suggest that increasing the uric acid concentration may represent one of the possible mechanisms of action of methylprednisolone in multiple sclerosis.""?",False, +9346353,Methylprednisolone affects chronic obstructive pulmonary disease,60,"OBJECTIVE: Compare the therapeutic efficacy of an oral/metered-dose inhaler (oral/MDI) regimen to an intravenous/nebulizer (I.V./neb) regimen of methylprednisolone, cefuroxime, and inhaled albuterol and ipratropium bromide in patients hospitalized for exacerbations of chronic obstructive pulmonary disease (COPD).","Is the triple ""Methylprednisolone affects chronic obstructive pulmonary disease"" supported by the sentence: ""OBJECTIVE: Compare the therapeutic efficacy of an oral/metered-dose inhaler (oral/MDI) regimen to an intravenous/nebulizer (I.V./neb) regimen of methylprednisolone, cefuroxime, and inhaled albuterol and ipratropium bromide in patients hospitalized for exacerbations of chronic obstructive pulmonary disease (COPD).""?",False, +9107378,Methylprednisolone affects Edema,61,"Similar to the CRPS clinical response to glucocorticoids, we now demonstrate that chronic hindpaw edema in the sciatic transection CRPS model is reversed by a continuous infusion of MP (3 mg/kg/day over 21 days), and this anti-edematous effect persists for at least 1 week after discontinuing MP.","Is the triple ""Methylprednisolone affects Edema"" supported by the sentence: ""Similar to the CRPS clinical response to glucocorticoids, we now demonstrate that chronic hindpaw edema in the sciatic transection CRPS model is reversed by a continuous infusion of MP (3 mg/kg/day over 21 days), and this anti-edematous effect persists for at least 1 week after discontinuing MP.""?",False, +8596544,Methylprednisolone affects asthma,62,STUDY OBJECTIVES: To assess whether IV methylprednisolone exerts a specific early effect on dyspnea in patients with an exacerbation of asthma.,"Is the triple ""Methylprednisolone affects asthma"" supported by the sentence: ""STUDY OBJECTIVES: To assess whether IV methylprednisolone exerts a specific early effect on dyspnea in patients with an exacerbation of asthma.""?",False, +8330909,Methylprednisolone affects systemic lupus erythematosus,63,REVIEWER'S CONCLUSIONS: Cyclophosphamide regimen treatment is a form of care in neuropsychiatric involvement in systemic lupus erythematosus with no evidence to prove better effectiveness and safety when compared with methylprednisolone.,"Is the triple ""Methylprednisolone affects systemic lupus erythematosus"" supported by the sentence: ""REVIEWER'S CONCLUSIONS: Cyclophosphamide regimen treatment is a form of care in neuropsychiatric involvement in systemic lupus erythematosus with no evidence to prove better effectiveness and safety when compared with methylprednisolone.""?",False, +19744632,Methylprednisolone disrupts Edema,64,"RESULTS: Both methylprednisolone and dexamethasone significantly reduced swelling and trismus (P < .05, Kruskal-Wallis test), whereas the methylprednisolone group had significantly less pain (P < .05, Kruskal-Wallis test) and consumed a lower amount of analgesics (P < .05, chi2 test) during the early postoperative days.","Is the triple ""Methylprednisolone disrupts Edema"" supported by the sentence: ""RESULTS: Both methylprednisolone and dexamethasone significantly reduced swelling and trismus (P < .05, Kruskal-Wallis test), whereas the methylprednisolone group had significantly less pain (P < .05, Kruskal-Wallis test) and consumed a lower amount of analgesics (P < .05, chi2 test) during the early postoperative days.""?",False, +18407557,Methylprednisolone disrupts thrombocytopenia,65,Methylprednisolone only inhibited granulocytopenia and thrombocytopenia when zymosan-activated serum or fibrinogen-depleted plasma were infused.,"Is the triple ""Methylprednisolone disrupts thrombocytopenia"" supported by the sentence: ""Methylprednisolone only inhibited granulocytopenia and thrombocytopenia when zymosan-activated serum or fibrinogen-depleted plasma were infused.""?",False, +11106658,Methylprednisolone disrupts Pain,66,"In addition, we detected that sufentanil provided prolonged pain relief up to 24 h when compared with control, whereas when we combined sufentanil plus methylprednisolone, we found that it further reduced pain and use of analgesics when compared with sufentanil.","Is the triple ""Methylprednisolone disrupts Pain"" supported by the sentence: ""In addition, we detected that sufentanil provided prolonged pain relief up to 24 h when compared with control, whereas when we combined sufentanil plus methylprednisolone, we found that it further reduced pain and use of analgesics when compared with sufentanil.""?",False, +8640603,Methylprednisolone disrupts Inflammation,67,These findings demonstrate that MP may suppress post-traumatic inflammatory reaction by inhibiting both the AP-1 and NF-kappaB transcription cascades via a GR mechanism.,"Is the triple ""Methylprednisolone disrupts Inflammation"" supported by the sentence: ""These findings demonstrate that MP may suppress post-traumatic inflammatory reaction by inhibiting both the AP-1 and NF-kappaB transcription cascades via a GR mechanism.""?",False, +23934495,Methylprednisolone prevents Cognitive impairment,68,"This study assessed the effectiveness of a ganciclovir, methylprednisolone, and immunoglobulin combination (TAGMIC) therapy in decreasing cognitive impairment and mortality among patients with Japanese encephalitis.","Is the triple ""Methylprednisolone prevents Cognitive impairment"" supported by the sentence: ""This study assessed the effectiveness of a ganciclovir, methylprednisolone, and immunoglobulin combination (TAGMIC) therapy in decreasing cognitive impairment and mortality among patients with Japanese encephalitis.""?",False, +20014108,Methylprednisolone prevents rheumatoid arthritis,69,"From indirect comparisons, most interventions showed decreased risk of developing RA compared to placebo at 12 months, reaching statistical significance for methotrexate (OR 0.16 [95% CI 0.08, 0.33]) and intramuscular methylprednisolone (OR 0.72 [95% CI 0.53, 0.99]).","Is the triple ""Methylprednisolone prevents rheumatoid arthritis"" supported by the sentence: ""From indirect comparisons, most interventions showed decreased risk of developing RA compared to placebo at 12 months, reaching statistical significance for methotrexate (OR 0.16 [95% CI 0.08, 0.33]) and intramuscular methylprednisolone (OR 0.72 [95% CI 0.53, 0.99]).""?",False, +18266414,Methylprednisolone prevents Abdominal pain,70,Treatment with a pulse of methylprednisolone reduced both abdominal pain and lesion size.,"Is the triple ""Methylprednisolone prevents Abdominal pain"" supported by the sentence: ""Treatment with a pulse of methylprednisolone reduced both abdominal pain and lesion size.""?",False, +14967074,Methylprednisolone prevents asthma,71,Methylprednisolone prevents propranolol-induced airway hyperreactivity in the Basenji-greyhound dog.,"Is the triple ""Methylprednisolone prevents asthma"" supported by the sentence: ""Methylprednisolone prevents propranolol-induced airway hyperreactivity in the Basenji-greyhound dog.""?",False, +9744990,Methylprednisolone prevents ovarian hyperstimulation syndrome,72,Administration of methylprednisolone to prevent severe ovarian hyperstimulation syndrome in patients undergoing in vitro fertilization.,"Is the triple ""Methylprednisolone prevents ovarian hyperstimulation syndrome"" supported by the sentence: ""Administration of methylprednisolone to prevent severe ovarian hyperstimulation syndrome in patients undergoing in vitro fertilization.""?",False, +8345063,Methylprednisolone prevents Pain,73,"Combined methylprednisolone, bupivacaine and morphine reduced pain, joint swelling, time of immobilization, duration of sick leave and return to sports after the arthroscopic procedure.","Is the triple ""Methylprednisolone prevents Pain"" supported by the sentence: ""Combined methylprednisolone, bupivacaine and morphine reduced pain, joint swelling, time of immobilization, duration of sick leave and return to sports after the arthroscopic procedure.""?",False, +8291272,Methylprednisolone prevents graft versus host disease,74,Forty-eight patients who underwent bone marrow transplantation (BMT) from serologically HLA-matched unrelated donors received tacrolimus (FK506) alone or with methotrexate (MTX) and/or methylprednisolone (mPSL) to prevent graft-versus-host disease (GVHD).,"Is the triple ""Methylprednisolone prevents graft versus host disease"" supported by the sentence: ""Forty-eight patients who underwent bone marrow transplantation (BMT) from serologically HLA-matched unrelated donors received tacrolimus (FK506) alone or with methotrexate (MTX) and/or methylprednisolone (mPSL) to prevent graft-versus-host disease (GVHD).""?",False, +7980138,Methylprednisolone prevents spinal cord injury,75,"Thus, calpeptin and methylprednisolone are found to be neuroprotective in SCI.","Is the triple ""Methylprednisolone prevents spinal cord injury"" supported by the sentence: ""Thus, calpeptin and methylprednisolone are found to be neuroprotective in SCI.""?",False, +7414405,Methylprednisolone prevents Edema,76,"Methylprednisolone prevents the development of autotomy and neuropathic edema in rats, but has no effect on nociceptive thresholds.","Is the triple ""Methylprednisolone prevents Edema"" supported by the sentence: ""Methylprednisolone prevents the development of autotomy and neuropathic edema in rats, but has no effect on nociceptive thresholds.""?",False, +18106042,Methylprednisolone predisposes pneumonia,77,Chronically impaired renal function and the use of methylprednisolone may be the risk factors for SP.,"Is the triple ""Methylprednisolone predisposes pneumonia"" supported by the sentence: ""Chronically impaired renal function and the use of methylprednisolone may be the risk factors for SP.""?",False, +9645180,Methylprednisolone predisposes Inflammation,78,"Because a common therapy for acute spinal cord injury is the use of an antiinflammatory synthetic glucocorticoid (methylprednisolone), we sought to determine mechanisms contributing to inflammation shortly after acute injury.","Is the triple ""Methylprednisolone predisposes Inflammation"" supported by the sentence: ""Because a common therapy for acute spinal cord injury is the use of an antiinflammatory synthetic glucocorticoid (methylprednisolone), we sought to determine mechanisms contributing to inflammation shortly after acute injury.""?",False, +12905337,Cefotaxime related to Sepsis,79,"Combined treatments of rG-CSF with cefotaxime, cefazolin, fosfomycin, gentamicin or amphotericin B were evaluated in systemic infections with Pseudomonas aeruginosa, Escherichia coli, Serratia marcescens, Staphylococcus aureus and Candida albicans in leucopenic mice induced by pretreatment with cyclophosphamide.","Is the triple ""Cefotaxime related to Sepsis"" supported by the sentence: ""Combined treatments of rG-CSF with cefotaxime, cefazolin, fosfomycin, gentamicin or amphotericin B were evaluated in systemic infections with Pseudomonas aeruginosa, Escherichia coli, Serratia marcescens, Staphylococcus aureus and Candida albicans in leucopenic mice induced by pretreatment with cyclophosphamide.""?",False, +24475300,Cefotaxime affects bacterial infectious disease,80,"One such marker, CTX-M-15, expressed by Enterobacteriaceae produces beta-lactamases, which hydrolyze the cephalosporin group of antibiotics, such as cefotaxime, used in the treatment of both Gram-positive and negative bacterial infections.","Is the triple ""Cefotaxime affects bacterial infectious disease"" supported by the sentence: ""One such marker, CTX-M-15, expressed by Enterobacteriaceae produces beta-lactamases, which hydrolyze the cephalosporin group of antibiotics, such as cefotaxime, used in the treatment of both Gram-positive and negative bacterial infections.""?",False, +23922029,Cefotaxime affects Sepsis,81,"CONS, Staphylococcus aureus, Enterococci, Escherichia coli, Klebsiella and Enterobacter represented 91.9% of LOS episodes and were susceptible to vancomycin and cefotaxime (96.1%), vancomycin and gentamicin (97.0%) and cloxacillin and gentamicin (38.1%).","Is the triple ""Cefotaxime affects Sepsis"" supported by the sentence: ""CONS, Staphylococcus aureus, Enterococci, Escherichia coli, Klebsiella and Enterobacter represented 91.9% of LOS episodes and were susceptible to vancomycin and cefotaxime (96.1%), vancomycin and gentamicin (97.0%) and cloxacillin and gentamicin (38.1%).""?",False, +18672205,Cefotaxime affects peritonitis,82,"The protective effect of cefotaxime, aztreonam and gentamicin in peritonitis induced by E. coli alone or combined with B. fragilis was evaluated by analysing mortality at 24 and 48 h after bacterial inoculation and treating the animals with two doses of each antibiotic.","Is the triple ""Cefotaxime affects peritonitis"" supported by the sentence: ""The protective effect of cefotaxime, aztreonam and gentamicin in peritonitis induced by E. coli alone or combined with B. fragilis was evaluated by analysing mortality at 24 and 48 h after bacterial inoculation and treating the animals with two doses of each antibiotic.""?",False, +15853591,Cefotaxime prevents Sepsis,83,"HR 810 had more potent protective effect than ceftazidime (CAZ), cefoperazone (CPZ), and cefotaxime (CTX) on systemic infections induced by Escherichia coli Ec-31, Staphylococcus aureus SMITH, and Serratia marcescens Sm-6 in mice.","Is the triple ""Cefotaxime prevents Sepsis"" supported by the sentence: ""HR 810 had more potent protective effect than ceftazidime (CAZ), cefoperazone (CPZ), and cefotaxime (CTX) on systemic infections induced by Escherichia coli Ec-31, Staphylococcus aureus SMITH, and Serratia marcescens Sm-6 in mice.""?",False, +19081412,Ceftriaxone prevents bacterial infectious disease,84,"1,480 patients, undergoing elective orthopedic and traumatic surgery, received intragluteal injections of ceftriaxone (Rocephin) to prevent bacterial infections.","Is the triple ""Ceftriaxone prevents bacterial infectious disease"" supported by the sentence: ""1,480 patients, undergoing elective orthopedic and traumatic surgery, received intragluteal injections of ceftriaxone (Rocephin) to prevent bacterial infections.""?",False, +25827448,Gefarnate related to gastric ulcer,85,Proceedings: A double blind trial of carbenoxolone and geranyl farnesylacetate in gastric ulcer.,"Is the triple ""Gefarnate related to gastric ulcer"" supported by the sentence: ""Proceedings: A double blind trial of carbenoxolone and geranyl farnesylacetate in gastric ulcer.""?",False, +24296137,Gefarnate related to duodenal ulcer,86,A controlled double-blind study was performed in 17 institutes using gefarnate as a control drug in order to investigate the therapeutic effect and safety of pirenzepine dihydrochloride (LS 519) in duodenal ulcer.,"Is the triple ""Gefarnate related to duodenal ulcer"" supported by the sentence: ""A controlled double-blind study was performed in 17 institutes using gefarnate as a control drug in order to investigate the therapeutic effect and safety of pirenzepine dihydrochloride (LS 519) in duodenal ulcer.""?",False, +25993651,Gefarnate disrupts gastric ulcer,87,Gefarnate at 300 mg/kg (p.o.) significantly inhibited phenylbutazone-induced gastric ulcers in rats but had no effect on other ulcer models.,"Is the triple ""Gefarnate disrupts gastric ulcer"" supported by the sentence: ""Gefarnate at 300 mg/kg (p.o.) significantly inhibited phenylbutazone-induced gastric ulcers in rats but had no effect on other ulcer models.""?",False, +17758516,Neobiotic related to Inflammation,88,We tested streptomycin (ST) and neomycin (NEO) as analgesic agents applied in situ in rat paw inflammation caused by formalin or carrageenan administration.,"Is the triple ""Neobiotic related to Inflammation"" supported by the sentence: ""We tested streptomycin (ST) and neomycin (NEO) as analgesic agents applied in situ in rat paw inflammation caused by formalin or carrageenan administration.""?",False, +10690423,Neobiotic related to burn,89,[ON THE ACTION OF A NEOMYCIN AND THIOPENICOL PREPARATION IN EXPERIMENTAL BURNS].,"Is the triple ""Neobiotic related to burn"" supported by the sentence: ""[ON THE ACTION OF A NEOMYCIN AND THIOPENICOL PREPARATION IN EXPERIMENTAL BURNS].""?",False, +20263460,Neobiotic affects neoplasm,90,"Therefore, we investigated the effect of long-term exposure of an antibiotic cocktail composed of Vancomycin, Neomycin, and Streptomycin, on tumor development and progression in the ApcMin/+ mouse, an established genetic model for familial adenomatous polyposis.","Is the triple ""Neobiotic affects neoplasm"" supported by the sentence: ""Therefore, we investigated the effect of long-term exposure of an antibiotic cocktail composed of Vancomycin, Neomycin, and Streptomycin, on tumor development and progression in the ApcMin/+ mouse, an established genetic model for familial adenomatous polyposis.""?",False, +19744068,Neobiotic affects Inflammation,91,Ultrahigh doses of gentamicin and clinically relevant doses of neomycin affect inflammation and angiogenesis in in vivo and in vitro models.,"Is the triple ""Neobiotic affects Inflammation"" supported by the sentence: ""Ultrahigh doses of gentamicin and clinically relevant doses of neomycin affect inflammation and angiogenesis in in vivo and in vitro models.""?",False, +24669492,Neobiotic disrupts bacterial infectious disease,92,"Biodegradable polyaspartamide (PASPAM) was grafted with several functional groups to implement diverse roles-octadecylamine (C 18 ) for nano-aggregate formation, dopamine (DOPA) for adhesive function, neomycin (NEO) for inhibition of bacterial infection.","Is the triple ""Neobiotic disrupts bacterial infectious disease"" supported by the sentence: ""Biodegradable polyaspartamide (PASPAM) was grafted with several functional groups to implement diverse roles-octadecylamine (C 18 ) for nano-aggregate formation, dopamine (DOPA) for adhesive function, neomycin (NEO) for inhibition of bacterial infection.""?",False, +17119153,Neobiotic disrupts neoplasm,93,Kaposi's sarcoma-associated herpesvirus-positive primary effusion lymphoma tumor formation in NOD/SCID mice is inhibited by neomycin and neamine blocking angiogenin's nuclear translocation.,"Is the triple ""Neobiotic disrupts neoplasm"" supported by the sentence: ""Kaposi's sarcoma-associated herpesvirus-positive primary effusion lymphoma tumor formation in NOD/SCID mice is inhibited by neomycin and neamine blocking angiogenin's nuclear translocation.""?",False, +26428369,Neobiotic prevents bacterial infectious disease,94,Neomycin and the combination of neomycin and bacitracin in the prevention of bacterial infection in surgery of the colon and/or rectum.,"Is the triple ""Neobiotic prevents bacterial infectious disease"" supported by the sentence: ""Neomycin and the combination of neomycin and bacitracin in the prevention of bacterial infection in surgery of the colon and/or rectum.""?",False, +25579460,BLINATUMOMAB related to Precursor B-Cell Lymphoblastic Leukemia-Lymphoma,95,Results of salvage therapy with mini-hyper-CVD and inotuzumab ozogamicin with or without blinatumomab in pre-B acute lymphoblastic leukemia.,"Is the triple ""BLINATUMOMAB related to Precursor B-Cell Lymphoblastic Leukemia-Lymphoma"" supported by the sentence: ""Results of salvage therapy with mini-hyper-CVD and inotuzumab ozogamicin with or without blinatumomab in pre-B acute lymphoblastic leukemia.""?",False, +22474123,BLINATUMOMAB related to hematopoietic and lymphoid system neoplasm,96,"The impressive clinical success of the continuously intravenously infused T cell-redirecting bispecific antibody (T-bsAb) blinatumomab (anti-CD19 x anti-CD3), and of engineered T cells expressing anti-CD19 chimeric antigen receptors (CAR-T cells) in hematological malignancies, has led to renewed interest in a novel cancer immunotherapy strategy that combines features of antibody- and cell-based therapies.","Is the triple ""BLINATUMOMAB related to hematopoietic and lymphoid system neoplasm"" supported by the sentence: ""The impressive clinical success of the continuously intravenously infused T cell-redirecting bispecific antibody (T-bsAb) blinatumomab (anti-CD19 x anti-CD3), and of engineered T cells expressing anti-CD19 chimeric antigen receptors (CAR-T cells) in hematological malignancies, has led to renewed interest in a novel cancer immunotherapy strategy that combines features of antibody- and cell-based therapies.""?",False, +21947892,BLINATUMOMAB related to acute lymphoblastic leukemia,97,Blinatumomab and inotuzumab ozogamycin represent promising alternatives to conventional chemotherapy in acute lymphoblastic leukaemia (ALL).,"Is the triple ""BLINATUMOMAB related to acute lymphoblastic leukemia"" supported by the sentence: ""Blinatumomab and inotuzumab ozogamycin represent promising alternatives to conventional chemotherapy in acute lymphoblastic leukaemia (ALL).""?",False, +27155094,Ciprofloxacin related to endophthalmitis,98,Efficacy of ciprofloxacin and dexamethasone in experimental pseudomonas endophthalmitis.,"Is the triple ""Ciprofloxacin related to endophthalmitis"" supported by the sentence: ""Efficacy of ciprofloxacin and dexamethasone in experimental pseudomonas endophthalmitis.""?",False, +16836665,Ciprofloxacin related to Crohn disease,99,CONCLUSIONS: Combination therapy of adalimumab and ciprofloxacin is more effective than adalimumab monotherapy to achieve fistula closure in CD.,"Is the triple ""Ciprofloxacin related to Crohn disease"" supported by the sentence: ""CONCLUSIONS: Combination therapy of adalimumab and ciprofloxacin is more effective than adalimumab monotherapy to achieve fistula closure in CD.""?",False, +19572117,Ciprofloxacin related to DNA Gyrase,100,"Tested substances displayed inhibitory effect towards E. coli DNA gyrase, though less than ciprofloxacin.","Is the triple ""Ciprofloxacin related to DNA Gyrase"" supported by the sentence: ""Tested substances displayed inhibitory effect towards E. coli DNA gyrase, though less than ciprofloxacin.""?",False, diff --git a/false_sentence_data.csv b/false_sentence_data.csv index bfed7f1..09b59bc 100644 --- a/false_sentence_data.csv +++ b/false_sentence_data.csv @@ -1,500 +1,501 @@ -2,,,,,Evaluation of granulated fenbendazole (22.2%) against induced and naturally occurring helminth infections in cats.,,,, -3,,,,,Fenbendazole resistance in O. ostertagi was confirmed with a total treatment failure in reducing worm burden: efficacy of 0%.,,,, -4,,,,,Symptoms of perianal itching and visualization of visible motile worms persisted for 6 months despite being treated with multiple courses of albendazole causing a lot of frustration and distress to the caregivers.,,,, -5,,,,,"Ovicidal effects of albendazole in human ascariasis, ancylostomiasis and trichuriasis.",,,, -6,,,,,"A combination of drugs Ivermectin, Diethylcarbamazine citrate and Albendazole is recommended by WHO to accelerate the Global Programme to Eliminate Lymphatic Filariasis (GPELF).",,,, -7,,,,,Effect of albendazole in experimental toxocariasis of mice.,,,, -8,,,,,"Given the low helminth prevalence in our children, the effect of albendazole on malaria is likely to be direct.",,,, -9,,,,,"Mass co-administration of ivermectin and albendazole by the LFEP had a significant effect on STH, which was further amplified by treatment with praziquantel and albendazole 4 months later.",,,, -10,,,,,The effect of single dose ivermectin alone or in combination with albendazole on Wuchereria bancrofti infection in primary school children in Tanzania.,,,, -11,,,,,"Additionally, compared with albendazole, it resulted in a significant reduction in adult worm and total larval counts; moreover, it caused a decrease in the number of larvae deposited in muscles, with a highly significant decrease in the inflammatory cell infiltrate around the larvae and a considerable decrease in the expression of the angiogenic marker vascular endothelial growth factor in muscles.",,,, -12,,,,,"Quarterly albendazole during childhood was associated with reduced incidence of clinical malaria (HR 0.85 (95% CI 0.73-0.98), p = 0.03).",,,, -13,,,,,CONCLUSIONS: Mebendazole and albendazole showed reduced efficacy against Ascaris lumbricoides and hookworm infections at the recommended doses.,,,, -14,,,,,Evaluation of effectiveness of diethylcarbamazine/albendazole combination in reduction of Wuchereria bancrofti infection using multiple infection parameters.,,,, -15,,,,,"Our evaluation suggests that although additional studies are needed to determine optimal treatment regimens for intestinal parasites, especially among young children and pregnant women, a five-day course of pre-departure albendazole was effective in reducing helminthic infection in treated refugees.",,,, -16,,,,,"The purpose of this study was the development and validation of an LC-MS-MS method for simultaneous analysis of ibuprofen (IBP), 2-hydroxyibuprofen (2-OH-IBP) enantiomers, and carboxyibuprofen (COOH-IBP) stereoisomers in fungi culture medium, to investigate the ability of some endophytic fungi to biotransform the chiral drug IBP into its metabolites.",,,, -17,,,,,"AIMS: To carry out a randomized clinical trial to compare the effect of palmitoylethanolamide (PEA) versus ibuprofen, a nonsteroidal anti-inflammatory drug (NSAID), for pain relief in temporomandibular joint (TMJ) osteoarthritis or arthralgia.",,,, -18,,,,,"We investigated the analgesic efficacy of single doses of ibuprofen, tramadol and pregabalin in menthol-evoked cold pain in a randomized, placebo-controlled four-way cross-over study in 20 healthy volunteers.",,,, -19,,,,,Double blind study on emorfazone and ibuprofen in dental pain and inflammation.,,,, -20,,,,,Glucosamine sulfate compared to ibuprofen in osteoarthritis of the knee.,,,, -21,,,,,INTRODUCTION: The anti-inflammatory and anticoagulant effects of ibuprofen and heparin may enhance skin perfusion in cutaneous scald burns.,,,, -22,,,,,"CONCLUSIONS: Ibuprofen-induced patent ductus arteriosus closure improved pulmonary mechanics, decreased total lung water, increased epithelial sodium channel expression, and decreased the detrimental effects of preterm birth on alveolarization.",,,, -23,,,,,Protein profile in neuroblastoma cells incubated with S- and R-enantiomers of ibuprofen by iTRAQ-coupled 2-D LC-MS/MS analysis: possible action of induced proteins on Alzheimer's disease.,,,, -24,,,,,Protective effect of glucosamine against ibuprofen-induced peptic ulcer in rats.,,,, -25,,,,,Ibuprofen-induced fever in Sjogren's syndrome.,,,, -26,,,,,There have been no prior definite cases reported of ibuprofen-induced pancreatitis.,,,, -27,,,,,"RESULTS: None of the studies established any of the COX-2 inhibitors as clearly better than ibuprofen, the current gold standard for the treatment of surgically induced dental pain.",,,, -28,,,,,Noncardiogenic pulmonary edema due to ibuprofen.,,,, -29,,,,,"In a double-blind cross-over study on 22 healthy subjects the analgesic efficacies of the antipyretic analgesic drugs ibuprofen, dipyrone and paracetamol were tested against placebo using a model of experimentally induced pain.",,,, -30,,,,,Unaltered ibuprofen-induced faecal blood loss upon coadministration of moclobemide.,,,, -31,,,,,The C5a antagonist (1 or 3 mg/kg/day) and/or ibuprofen (30 mg/kg/day) were administered orally on a daily basis either before or after arthritis induction.,,,, -32,,,,,RESULTS: Ketoprofen 50 mg t.d.s. suppressed prostaglandin synthesis to a significantly greater extent than ibuprofen and caused significantly more gastroduodenal injury.,,,, -33,,,,,The duration of action of sustained-release ibuprofen ('Brufen Retard') was investigated in a 14-day double-blind study involving 14 osteoarthritis and 10 rheumatoid arthritis patients.,,,, -34,,,,,This study attempts to investigate the effect of ibuprofen on reducing eye pain and migraine headaches caused by trochleitis.,,,, -35,,,,,"Ibuprofen suppresses the production of various pro-inflammatory cytokines that are implicated in the ""cytokine storm"" and subsequent ARDS in COVID-19 disease.",,,, -36,,,,,"After adjusting for covariates, the risk of BPD was associated independently with ibuprofen exposure (odds ratios (OR) 2.296, 95% confidence interval (CI): 1.166-4.522, p = 0.016).",,,, -37,,,,,The opposite effect of ibuprofen on ethanol-induced cognitive impairment as measured by two lateralized functions is consistent with the reports in tissue and animal models that central nervous system effects of ethanol may be mediated at least in part by prostaglandins.,,,, -38,,,,,"On post-partum day five, she began complaining of headaches, initially responsive to ibuprofen but eventually worsened with no relief.",,,, -39,,,,,"Because ibuprofen protects from septic lung injury, we studied the effect of ibuprofen in oxidant lung injury from phosgene.",,,, -40,,,,,The efficacy and tolerance of ibuprofen retard at a dose of 2 x 800 mg daily was investigated in an open multicenter study over a period of 3 weeks on 7931 out-patients with activated degenerative joint disease and/or extraarticular rheumatic symptoms.,,,, -41,,,,,"Overall, we found no relation between regular aspirin use and cognitive decline, but long-term use of ibuprofen may be related to decreased rates of cognitive decline in older persons.",,,, -42,,,,,"Subdiaphragmatic vagotomy or 7-nitroindazole reduced, icatibant, DALBK, IL-1ra, aminoguanidine and dipyrone abolished, while ibuprofen and celecoxib failed to affect Tsv-induced fever.",,,, -43,,,,,Reduced incidence of gastroduodenal ulcers associated with lumiracoxib compared with ibuprofen in patients with rheumatoid arthritis.,,,, -44,,,,,It was also investigated whether the use of ibuprofen or paracetamol would influence the amount of surgical bleeding.,,,, -45,,,,,"In a randomised, placebo-controlled, double-blind trial of prophylaxis with ibuprofen, the rate of patent ductus arteriosus associated with ibuprofen was 19% compared with 42% with placebo.",,,, -46,,,,,"The purpose of this study was to examine the effects of ibuprofen on delayed onset muscle soreness (DOMS), indirect markers of muscle damage and muscular performance.",,,, -47,,,,,CONCLUSIONS: Pretreatment with ibuprofen before elective total hip surgery increases the perioperative blood loss significantly.,,,, -48,,,,,"The data suggest that nimesulide and ibuprofen, in addition to their anti-inflammatory and analgesic benefits, may also have a protective effect in osteoarthritis through the inhibition of apoptosis in chondrocytes.",,,, -49,,,,,Pretreatment with ibuprofen blocked the fever induced by RANTES.,,,, -50,,,,,This study evaluated whether administration of the pharmacologically active S(+)-isomer of ibuprofen suppresses acute pain and plasma beta-endorphin levels in the oral surgery model of acute pain.,,,, -51,,,,,"On the other hand, in subgroup B, no improvement in flexibility or reduction in muscle soreness was found in patients who took ibuprofen.",,,, -52,,,,,"This is termed, Celery Seed Extract (CSE) and has been found to be at least as effective as aspirin, ibuprofen, and naproxen in suppressing arthritis in a model of polyarthritis.",,,, -53,,,,,INTRODUCTION: Hospitalized patients are often unable to ingest or tolerate oral antipyretics and recently an aqueous formulation of intravenous (IV) ibuprofen was approved by the US-FDA for the reduction of fever in adults.,,,, -54,,,,,"OBJECTIVES: This study compared the analgesic effectiveness of acetaminophen-codeine with that of ibuprofen for children with acute traumatic extremity pain, with the hypothesis that the two medications would demonstrate equivalent reduction in pain scores in an emergency department (ED) setting.",,,, -55,,,,,"Thus, the anti-inflammatory drug ibuprofen, which has been associated with reduced AD risk in human epidemiological studies, can significantly delay some forms of AD pathology, including amyloid deposition, when administered early in the disease course of a transgenic mouse model of AD.",,,, -56,,,,,"The hypoxia, hypertension and increased prostanoids were prevented using ibuprofen.",,,, -57,,,,,"The Effect of Ibuprofen Dosing Interval on Post-Tonsillectomy Outcomes in Children: A Quality Improvement Study.OBJECTIVE: In this Quality Improvement (QI project) it was hypothesized that an increase in dosing intervals for postoperative analgesia when alternating Ibuprofen and Acetaminophen would reduce post-tonsillectomy hemorrhage (PTH) rates for those undergoing tonsillectomies with or without adenoidectomy, while maintaining the standard of postoperative analgesia and reducing visits to the Emergency Room (ER) for reasons other than PTH.",,,, -58,,,,,Studies show that ibuprofen demonstrates superior efficacy in fever reduction compared to acetaminophen.,,,, -59,,,,,IV Ibuprofen for Prevention of Post-Ercp Pancreatitis in Children: A Randomized Placebo-Controlled Feasibility Study.,,,, -60,,,,,Altitude Sickness Prevention with Ibuprofen Relative to Acetazolamide.,,,, -61,,,,,"In conclusion, prednisone, ibuprofen and betamethasone may prevent OA by suppressing the expression of IL-6 and IL-8, subsequently inactivating NF-kappaB and STAT3 pathways, and ultimately, leading to decreased levels of collagen I, MMP-1, and MMP-13.",,,, -62,,,,,"This study aims to determine the therapeutic effects of ibuprofen, diphenhydramine and aluminum magnesium simethicone (AlMgS) syrup on reducing oral aphthous ulcer pain.",,,, -63,,,,,"CONCLUSIONS: Considering the results of the study, reflexology was superior to Ibuprofen on reducing dysmenorrhea and its treatment effect continued even after discontinuing the intervention in the third cycle.",,,, -64,,,,,CONCLUSION: We conclude that pain therapy with an almost peripherally acting drug such as ibuprofen can reduce osteoporosis-associated chronic pain better than a centrally acting pain medication such as tramadol.,,,, -65,,,,,The objective of this study was to determine whether pretreatment with ibuprofen would prevent the onset or decrease the severity of headache that occurs after ECT.,,,, -66,,,,,The results of this study reveal that intake of ibuprofen can decrease muscle soreness induced after eccentric exercise but cannot assist in restoring muscle function.,,,, -67,,,,,The objective of our study was to determine the role of ibuprofen in protecting neutropenic rats from cardiopulmonary injury due to endotoxemia.,,,, -68,,,,,"To determine if prophylactic etodolac would significantly reduce postendodontic pain, when compared with ibuprofen or placebo, 36 patients consented to single blind oral administration of either 400 mg of etodolac, 600 mg of ibuprofen, or a placebo, before conventional one-appointment root canal therapy.",,,, -69,,,,,UNLABELLED: The aim of our study was to evaluate whether the prophylactic use of ibuprofen would reduce the incidence of significant patent ductus arteriosus (PDA) and to confirm the effectiveness of ibuprofen as rescue treatment in closing PDA.,,,, -70,,,,,"Nonsteroidal anti-inflammatory drugs (NSAIDs) such as aspirin, indomethacin and ibuprofen are the most widely used drugs for pain, arthritis, cardiovascular diseases and, more recently, the prevention of colon cancer and Alzheimer disease.",,,, -71,,,,,Aggravation of seizure-associated microvascular injuries by ibuprofen may involve multiple pathways.,,,, -72,,,,,"Use of paracetamol, ibuprofen or aspirin in pregnancy and risk of cerebral palsy in the child.",,,, -73,,,,,"More than two cycles of ibuprofen was significantly associated with an increased risk for bronchopulmonary dysplasia (odds ratio [OR], 2.81; p = 0.03) and acute renal failure (OR, 3.81; p = 0.09).",,,, -74,,,,,OBJECTIVE: Non-steroidal anti-inflammatory drugs such as ibuprofen have a protective role on risk of Alzheimer's disease (AD).,,,, -75,,,,,"There seems to be a marked gradient of risk for acute kidney injury across agents, specifically for indomethacin, ibuprofen, and rofecoxib.",,,, -76,,,,,"Significant heterogeneity was present for the NSAIDs; e.g., ibuprofen was associated with an increased overall fracture risk (OR = 2.09, 95% CI 2.00-2.18 for <20 DDD), while celecoxib was not (OR = 0.76, 95% CI 0.51-1.13 for <20 DDD, 2P < 0.01 for comparison).",,,, -77,,,,,One should be more critical about ivabradine and low-dose digoxin in diastolic heart failure.,,,, -78,,,,,"Preclinical studies of ivabradine in animal models with induced AF demonstrated a reduction in HR, with no significant worsening of QT interval or mean arterial pressure.",,,, -79,,,,,"In this review, we summarize the current knowledge of the HCN4 channel and ivabradine, including the function of HCN4 in cardiac pacemaking, the mechanism of action of If inhibition by ivabradine, and the pharmacological and clinical effects of ivabradine in cardiac diseases as HF, coronary artery disease, and atrial fibrillation.",,,, -80,,,,,Small studies have recently investigated the role of ivabradine in MS in sinus rhythm.,,,, -81,,,,,The role of Ivabradine in Diastolic Heart Failure with preserved Ejection Fraction.,,,, +SENTENCE_ID,PMID,TYPE,NUMBER,SENT_START_INDEX,SENTENCE,SECTION_HEADER,NORMALIZED_SECTION_HEADER,Column,Column +1,,,,,Evaluation of granulated fenbendazole (22.2%) against induced and naturally occurring helminth infections in cats.,,,, +2,,,,,Fenbendazole resistance in O. ostertagi was confirmed with a total treatment failure in reducing worm burden: efficacy of 0%.,,,, +3,,,,,Symptoms of perianal itching and visualization of visible motile worms persisted for 6 months despite being treated with multiple courses of albendazole causing a lot of frustration and distress to the caregivers.,,,, +4,,,,,"Ovicidal effects of albendazole in human ascariasis, ancylostomiasis and trichuriasis.",,,, +5,,,,,"A combination of drugs Ivermectin, Diethylcarbamazine citrate and Albendazole is recommended by WHO to accelerate the Global Programme to Eliminate Lymphatic Filariasis (GPELF).",,,, +6,,,,,Effect of albendazole in experimental toxocariasis of mice.,,,, +7,,,,,"Given the low helminth prevalence in our children, the effect of albendazole on malaria is likely to be direct.",,,, +8,,,,,"Mass co-administration of ivermectin and albendazole by the LFEP had a significant effect on STH, which was further amplified by treatment with praziquantel and albendazole 4 months later.",,,, +9,,,,,The effect of single dose ivermectin alone or in combination with albendazole on Wuchereria bancrofti infection in primary school children in Tanzania.,,,, +10,,,,,"Additionally, compared with albendazole, it resulted in a significant reduction in adult worm and total larval counts; moreover, it caused a decrease in the number of larvae deposited in muscles, with a highly significant decrease in the inflammatory cell infiltrate around the larvae and a considerable decrease in the expression of the angiogenic marker vascular endothelial growth factor in muscles.",,,, +11,,,,,"Quarterly albendazole during childhood was associated with reduced incidence of clinical malaria (HR 0.85 (95% CI 0.73-0.98), p = 0.03).",,,, +12,,,,,CONCLUSIONS: Mebendazole and albendazole showed reduced efficacy against Ascaris lumbricoides and hookworm infections at the recommended doses.,,,, +13,,,,,Evaluation of effectiveness of diethylcarbamazine/albendazole combination in reduction of Wuchereria bancrofti infection using multiple infection parameters.,,,, +14,,,,,"Our evaluation suggests that although additional studies are needed to determine optimal treatment regimens for intestinal parasites, especially among young children and pregnant women, a five-day course of pre-departure albendazole was effective in reducing helminthic infection in treated refugees.",,,, +15,,,,,"The purpose of this study was the development and validation of an LC-MS-MS method for simultaneous analysis of ibuprofen (IBP), 2-hydroxyibuprofen (2-OH-IBP) enantiomers, and carboxyibuprofen (COOH-IBP) stereoisomers in fungi culture medium, to investigate the ability of some endophytic fungi to biotransform the chiral drug IBP into its metabolites.",,,, +16,,,,,"AIMS: To carry out a randomized clinical trial to compare the effect of palmitoylethanolamide (PEA) versus ibuprofen, a nonsteroidal anti-inflammatory drug (NSAID), for pain relief in temporomandibular joint (TMJ) osteoarthritis or arthralgia.",,,, +17,,,,,"We investigated the analgesic efficacy of single doses of ibuprofen, tramadol and pregabalin in menthol-evoked cold pain in a randomized, placebo-controlled four-way cross-over study in 20 healthy volunteers.",,,, +18,,,,,Double blind study on emorfazone and ibuprofen in dental pain and inflammation.,,,, +19,,,,,Glucosamine sulfate compared to ibuprofen in osteoarthritis of the knee.,,,, +20,,,,,INTRODUCTION: The anti-inflammatory and anticoagulant effects of ibuprofen and heparin may enhance skin perfusion in cutaneous scald burns.,,,, +21,,,,,"CONCLUSIONS: Ibuprofen-induced patent ductus arteriosus closure improved pulmonary mechanics, decreased total lung water, increased epithelial sodium channel expression, and decreased the detrimental effects of preterm birth on alveolarization.",,,, +22,,,,,Protein profile in neuroblastoma cells incubated with S- and R-enantiomers of ibuprofen by iTRAQ-coupled 2-D LC-MS/MS analysis: possible action of induced proteins on Alzheimer's disease.,,,, +23,,,,,Protective effect of glucosamine against ibuprofen-induced peptic ulcer in rats.,,,, +24,,,,,Ibuprofen-induced fever in Sjogren's syndrome.,,,, +25,,,,,There have been no prior definite cases reported of ibuprofen-induced pancreatitis.,,,, +26,,,,,"RESULTS: None of the studies established any of the COX-2 inhibitors as clearly better than ibuprofen, the current gold standard for the treatment of surgically induced dental pain.",,,, +27,,,,,Noncardiogenic pulmonary edema due to ibuprofen.,,,, +28,,,,,"In a double-blind cross-over study on 22 healthy subjects the analgesic efficacies of the antipyretic analgesic drugs ibuprofen, dipyrone and paracetamol were tested against placebo using a model of experimentally induced pain.",,,, +29,,,,,Unaltered ibuprofen-induced faecal blood loss upon coadministration of moclobemide.,,,, +30,,,,,The C5a antagonist (1 or 3 mg/kg/day) and/or ibuprofen (30 mg/kg/day) were administered orally on a daily basis either before or after arthritis induction.,,,, +31,,,,,RESULTS: Ketoprofen 50 mg t.d.s. suppressed prostaglandin synthesis to a significantly greater extent than ibuprofen and caused significantly more gastroduodenal injury.,,,, +32,,,,,The duration of action of sustained-release ibuprofen ('Brufen Retard') was investigated in a 14-day double-blind study involving 14 osteoarthritis and 10 rheumatoid arthritis patients.,,,, +33,,,,,This study attempts to investigate the effect of ibuprofen on reducing eye pain and migraine headaches caused by trochleitis.,,,, +34,,,,,"Ibuprofen suppresses the production of various pro-inflammatory cytokines that are implicated in the ""cytokine storm"" and subsequent ARDS in COVID-19 disease.",,,, +35,,,,,"After adjusting for covariates, the risk of BPD was associated independently with ibuprofen exposure (odds ratios (OR) 2.296, 95% confidence interval (CI): 1.166-4.522, p = 0.016).",,,, +36,,,,,The opposite effect of ibuprofen on ethanol-induced cognitive impairment as measured by two lateralized functions is consistent with the reports in tissue and animal models that central nervous system effects of ethanol may be mediated at least in part by prostaglandins.,,,, +37,,,,,"On post-partum day five, she began complaining of headaches, initially responsive to ibuprofen but eventually worsened with no relief.",,,, +38,,,,,"Because ibuprofen protects from septic lung injury, we studied the effect of ibuprofen in oxidant lung injury from phosgene.",,,, +39,,,,,The efficacy and tolerance of ibuprofen retard at a dose of 2 x 800 mg daily was investigated in an open multicenter study over a period of 3 weeks on 7931 out-patients with activated degenerative joint disease and/or extraarticular rheumatic symptoms.,,,, +40,,,,,"Overall, we found no relation between regular aspirin use and cognitive decline, but long-term use of ibuprofen may be related to decreased rates of cognitive decline in older persons.",,,, +41,,,,,"Subdiaphragmatic vagotomy or 7-nitroindazole reduced, icatibant, DALBK, IL-1ra, aminoguanidine and dipyrone abolished, while ibuprofen and celecoxib failed to affect Tsv-induced fever.",,,, +42,,,,,Reduced incidence of gastroduodenal ulcers associated with lumiracoxib compared with ibuprofen in patients with rheumatoid arthritis.,,,, +43,,,,,It was also investigated whether the use of ibuprofen or paracetamol would influence the amount of surgical bleeding.,,,, +44,,,,,"In a randomised, placebo-controlled, double-blind trial of prophylaxis with ibuprofen, the rate of patent ductus arteriosus associated with ibuprofen was 19% compared with 42% with placebo.",,,, +45,,,,,"The purpose of this study was to examine the effects of ibuprofen on delayed onset muscle soreness (DOMS), indirect markers of muscle damage and muscular performance.",,,, +46,,,,,CONCLUSIONS: Pretreatment with ibuprofen before elective total hip surgery increases the perioperative blood loss significantly.,,,, +47,,,,,"The data suggest that nimesulide and ibuprofen, in addition to their anti-inflammatory and analgesic benefits, may also have a protective effect in osteoarthritis through the inhibition of apoptosis in chondrocytes.",,,, +48,,,,,Pretreatment with ibuprofen blocked the fever induced by RANTES.,,,, +49,,,,,This study evaluated whether administration of the pharmacologically active S(+)-isomer of ibuprofen suppresses acute pain and plasma beta-endorphin levels in the oral surgery model of acute pain.,,,, +50,,,,,"On the other hand, in subgroup B, no improvement in flexibility or reduction in muscle soreness was found in patients who took ibuprofen.",,,, +51,,,,,"This is termed, Celery Seed Extract (CSE) and has been found to be at least as effective as aspirin, ibuprofen, and naproxen in suppressing arthritis in a model of polyarthritis.",,,, +52,,,,,INTRODUCTION: Hospitalized patients are often unable to ingest or tolerate oral antipyretics and recently an aqueous formulation of intravenous (IV) ibuprofen was approved by the US-FDA for the reduction of fever in adults.,,,, +53,,,,,"OBJECTIVES: This study compared the analgesic effectiveness of acetaminophen-codeine with that of ibuprofen for children with acute traumatic extremity pain, with the hypothesis that the two medications would demonstrate equivalent reduction in pain scores in an emergency department (ED) setting.",,,, +54,,,,,"Thus, the anti-inflammatory drug ibuprofen, which has been associated with reduced AD risk in human epidemiological studies, can significantly delay some forms of AD pathology, including amyloid deposition, when administered early in the disease course of a transgenic mouse model of AD.",,,, +55,,,,,"The hypoxia, hypertension and increased prostanoids were prevented using ibuprofen.",,,, +56,,,,,"The Effect of Ibuprofen Dosing Interval on Post-Tonsillectomy Outcomes in Children: A Quality Improvement Study.OBJECTIVE: In this Quality Improvement (QI project) it was hypothesized that an increase in dosing intervals for postoperative analgesia when alternating Ibuprofen and Acetaminophen would reduce post-tonsillectomy hemorrhage (PTH) rates for those undergoing tonsillectomies with or without adenoidectomy, while maintaining the standard of postoperative analgesia and reducing visits to the Emergency Room (ER) for reasons other than PTH.",,,, +57,,,,,Studies show that ibuprofen demonstrates superior efficacy in fever reduction compared to acetaminophen.,,,, +58,,,,,IV Ibuprofen for Prevention of Post-Ercp Pancreatitis in Children: A Randomized Placebo-Controlled Feasibility Study.,,,, +59,,,,,Altitude Sickness Prevention with Ibuprofen Relative to Acetazolamide.,,,, +60,,,,,"In conclusion, prednisone, ibuprofen and betamethasone may prevent OA by suppressing the expression of IL-6 and IL-8, subsequently inactivating NF-kappaB and STAT3 pathways, and ultimately, leading to decreased levels of collagen I, MMP-1, and MMP-13.",,,, +61,,,,,"This study aims to determine the therapeutic effects of ibuprofen, diphenhydramine and aluminum magnesium simethicone (AlMgS) syrup on reducing oral aphthous ulcer pain.",,,, +62,,,,,"CONCLUSIONS: Considering the results of the study, reflexology was superior to Ibuprofen on reducing dysmenorrhea and its treatment effect continued even after discontinuing the intervention in the third cycle.",,,, +63,,,,,CONCLUSION: We conclude that pain therapy with an almost peripherally acting drug such as ibuprofen can reduce osteoporosis-associated chronic pain better than a centrally acting pain medication such as tramadol.,,,, +64,,,,,The objective of this study was to determine whether pretreatment with ibuprofen would prevent the onset or decrease the severity of headache that occurs after ECT.,,,, +65,,,,,The results of this study reveal that intake of ibuprofen can decrease muscle soreness induced after eccentric exercise but cannot assist in restoring muscle function.,,,, +66,,,,,The objective of our study was to determine the role of ibuprofen in protecting neutropenic rats from cardiopulmonary injury due to endotoxemia.,,,, +67,,,,,"To determine if prophylactic etodolac would significantly reduce postendodontic pain, when compared with ibuprofen or placebo, 36 patients consented to single blind oral administration of either 400 mg of etodolac, 600 mg of ibuprofen, or a placebo, before conventional one-appointment root canal therapy.",,,, +68,,,,,UNLABELLED: The aim of our study was to evaluate whether the prophylactic use of ibuprofen would reduce the incidence of significant patent ductus arteriosus (PDA) and to confirm the effectiveness of ibuprofen as rescue treatment in closing PDA.,,,, +69,,,,,"Nonsteroidal anti-inflammatory drugs (NSAIDs) such as aspirin, indomethacin and ibuprofen are the most widely used drugs for pain, arthritis, cardiovascular diseases and, more recently, the prevention of colon cancer and Alzheimer disease.",,,, +70,,,,,Aggravation of seizure-associated microvascular injuries by ibuprofen may involve multiple pathways.,,,, +71,,,,,"Use of paracetamol, ibuprofen or aspirin in pregnancy and risk of cerebral palsy in the child.",,,, +72,,,,,"More than two cycles of ibuprofen was significantly associated with an increased risk for bronchopulmonary dysplasia (odds ratio [OR], 2.81; p = 0.03) and acute renal failure (OR, 3.81; p = 0.09).",,,, +73,,,,,OBJECTIVE: Non-steroidal anti-inflammatory drugs such as ibuprofen have a protective role on risk of Alzheimer's disease (AD).,,,, +74,,,,,"There seems to be a marked gradient of risk for acute kidney injury across agents, specifically for indomethacin, ibuprofen, and rofecoxib.",,,, +75,,,,,"Significant heterogeneity was present for the NSAIDs; e.g., ibuprofen was associated with an increased overall fracture risk (OR = 2.09, 95% CI 2.00-2.18 for <20 DDD), while celecoxib was not (OR = 0.76, 95% CI 0.51-1.13 for <20 DDD, 2P < 0.01 for comparison).",,,, +76,,,,,One should be more critical about ivabradine and low-dose digoxin in diastolic heart failure.,,,, +77,,,,,"Preclinical studies of ivabradine in animal models with induced AF demonstrated a reduction in HR, with no significant worsening of QT interval or mean arterial pressure.",,,, +78,,,,,"In this review, we summarize the current knowledge of the HCN4 channel and ivabradine, including the function of HCN4 in cardiac pacemaking, the mechanism of action of If inhibition by ivabradine, and the pharmacological and clinical effects of ivabradine in cardiac diseases as HF, coronary artery disease, and atrial fibrillation.",,,, +79,,,,,Small studies have recently investigated the role of ivabradine in MS in sinus rhythm.,,,, +80,,,,,The role of Ivabradine in Diastolic Heart Failure with preserved Ejection Fraction.,,,, +81,,,,,"Other large trials are also underway to assess the effects of ivabradine on heart failure, acute coronary syndromes, CAD, and other cardiovascular disorders.",,,, 82,,,,,"Other large trials are also underway to assess the effects of ivabradine on heart failure, acute coronary syndromes, CAD, and other cardiovascular disorders.",,,, -83,,,,,"Other large trials are also underway to assess the effects of ivabradine on heart failure, acute coronary syndromes, CAD, and other cardiovascular disorders.",,,, -84,,,,,Effective suppression of atrial fibrillation by ivabradine: Novel target for an established drug?,,,, -85,,,,,[SIGNIFY study is a disappointment. Ivabradine cannot stop of the progression of coronary heart disease].,,,, -86,,,,,RESULTS: Heart rate reduction and prevention of postoperative AF or tachyarrhythmia with combined therapy was more effective than with metoprolol or ivabradine alone during the immediate postoperative management of cardiac surgery patients.,,,, -87,,,,,"During exercise, ivabradine dose dependently and significantly reduced the exercise-induced tachycardia (-17, -21, and -32% at 0.25, 0.5, and 1 mg/kg, respectively, versus saline) without altering myocardial contractility nor mean ejection wall stress.",,,, -88,,,,,Recent trials reported that risk of atrial fibrillation (AF) is increased in patients using ivabradine compared with controls.,,,, -89,,,,,Randomized comparative study of cefixime versus cephalexin in acute bacterial exacerbations of chronic bronchitis.,,,, -90,,,,,Alterations of the pilQ gene in Neisseria gonorrhoeae are unlikely contributors to decreased susceptibility to ceftriaxone and cefixime in clinical gonococcal strains.,,,, -91,,,,,"Because of the emergence of these bacteria, other antimicrobial agents, both old and new, have been advocated for treatment and prevention of otitis media; amoxicillin-clavulanate, cefuroxime axetil, and cefixime are the newer agents.",,,, -92,,,,,Experimental comparison of protective characteristics of enalapril and trimetazidine in diabetic nephropathy.,,,, -93,,,,,This study aimed to investigate the role of TMZ in diabetic nephropathy (DN) and its potential mechanisms.,,,, -94,,,,,Objective: This study investigates the effect of TMZ in sunitinib-induced cardiotoxicity in vivo and in vitro and molecular mechanisms.,,,, -95,,,,,The role of trimetazidine in cardiovascular disease: beyond an anti-anginal agent.,,,, -96,,,,,"Trimetazidine, 2.5 mg/kg/day i.p. for 3 days before doxorubicin administration plus 2.5 mg/kg/day p.o. for 10 weeks, was unable to prevent the development of doxorubicin-induced long-term cardiotoxicity.",,,, -97,,,,,Ranolazine was more effective than lidocaine in terminating persistent AF and in preventing the induction of AF.,,,, -98,,,,,Role of Ranolazine in cardiovascular disease and diabetes: Exploring beyond angina.,,,, -99,,,,,"Furthermore, the activated Akt/mTOR signaling pathway induced by AF was further activated by ranolazine.",,,, -100,,,,,Recent evidence of beneficial effects of ranolazine (RAN) in type II diabetes motivates interest in the role of the late sodium current (INaL) in glucose-stimulated insulin secretion.,,,, -101,,,,,Effect of ranolazine in preventing postoperative atrial fibrillation in patients undergoing coronary revascularization surgery.,,,, -102,,,,,The anti-ischemic mechanism of action of ranolazine in stable ischemic heart disease.,,,, -103,,,,,Atrial-selective/predominant sodium channel blockers such as ranolazine effectively suppress AF in experimental models of AF involving canine isolated right atrial preparations at concentrations that produce little to no effect on ventricular electrophysiologic parameters.,,,, -104,,,,,Ranolazine has been shown to decrease angina pectoris frequency and nitroglycerin consumption.,,,, -105,,,,,BACKGROUND: Ranolazine has been shown to reduce myocardial ischemia and symptom severity among selected patients with chronic angina.,,,, -106,,,,,"Dominant frequency (DF) of AF was reduced by ranolazine in left atrium from 11.7 (10.7-20.5) Hz to 7.6 (2.9-8.8) Hz (P = 0.02, n = 6).",,,, -107,,,,,"After adjusting for potential sources of bias through propensity-score matched-pair analysis and conditional logistic regression, ranolazine was an independent predictor of preventing POAF (p < 0.0001).",,,, -108,,,,,Prednisolone furthers T-cell immunodeficiency and also reduces the intensity of autoimmune reactions in multiple sclerosis.,,,, -109,,,,,[Pharmacokinetics of prednisolone in adrenal insufficiency ].,,,, -110,,,,,It is concluded that VAP is effective therapy in AIL.,,,, -111,,,,,A thermographic assessment of three intra-articular prednisolone analogues given in rheumatoid synovitis.,,,, -112,,,,,The effect of small doses of prednisolone on the incidence of subcutaneous sarcomas induced by 3-methylcholanthrene in virgin female Swiss mice.,,,, -113,,,,,[Effects of chromocarb diethylamine and prednisolone in experimental uveitis induced by clove oil in rabbits].,,,, -114,,,,,[Effect of prednisolone and heparin on circulating T- and B-lymphocytes in glomerulonephritis and systemic lupus erythematosus].,,,, -115,,,,,[Effects of prednisolone on thyroidal-123I uptake in subacute thyroiditis].,,,, -116,,,,,"Blood Eosinophil Depletion with Mepolizumab, Benralizumab and Prednisolone in Eosinophilic Asthma.",,,, -117,,,,,[Prednisolone and aspirin combination therapy in habitual abortion with autoantibodies].,,,, -118,,,,,"To illustrate this, we used an example of cost-effectiveness analysis for docetaxel in combination with prednisolone in metastatic hormone-refractory prostate cancer.",,,, -119,,,,,Prednisolone is associated with a worse bone mineral density in primary adrenal insufficiency.,,,, -120,,,,,CONCLUSIONS: Prednisolone was more effective in inducing response than itraconazole in acute-stage ABPA.,,,, -121,,,,,"Purpose: The aim of this study was to compare asparaginase-related toxicities in two asparaginase preparations, namely native Escherichia coli L-asparaginase (L-ASP) and pegylated asparaginase (PEG-ASP) in combination with ifosfamide, methotrexate, etoposide, and prednisolone (IMEP) in natural killer (NK)/T-cell lymphoma (NTCL).",,,, -122,,,,,Prednisolone combined with adjunctive immunosuppression is not superior to prednisolone alone in terms of efficacy and safety in giant cell arteritis: meta-analysis.,,,, -123,,,,,CONCLUSION: GVP is well-tolerated regimen with high response rate and needs to be tested in late relapsed HL.,,,, -124,,,,,Early treatment with addition of low dose prednisolone to methotrexate improves therapeutic outcome in severe psoriatic arthritis.,,,, -125,,,,,"CONCLUSION: Flu/Cy/ATG conditioning regimen, bone marrow as stem cell source and CSA, prednisolone and short methotrexate regimen were associated with better survival in AA.",,,, -126,,,,,Effect of addition of short course of prednisolone to gluten-free diet on mucosal epithelial cell regeneration and apoptosis in celiac disease: a pilot randomized controlled trial.,,,, -127,,,,,Coadministration of cyclosporin a with prednisolone in acute interstitial pneumonia complicating polymyositis/dermatomyositis.,,,, -128,,,,,"Efficacy of immunoglobulin plus prednisolone for prevention of coronary artery abnormalities in severe Kawasaki disease (RAISE study): a randomised, open-label, blinded-endpoints trial.",,,, -129,,,,,"Response of vincristine, melphalan, cyclophosphamide and prednisolone in refractory multiple myeloma.",,,, -130,,,,,Pyruvate kinase M2 and prednisolone resistance in acute lymphoblastic leukemia.,,,, -131,,,,,"Stimulation with prednisolone and TNFalpha reduced GDF-5 expression in OA and RA fibroblasts, whereas MTX and IL-1beta revealed minor or no relevant change.",,,, +83,,,,,Effective suppression of atrial fibrillation by ivabradine: Novel target for an established drug?,,,, +84,,,,,[SIGNIFY study is a disappointment. Ivabradine cannot stop of the progression of coronary heart disease].,,,, +85,,,,,RESULTS: Heart rate reduction and prevention of postoperative AF or tachyarrhythmia with combined therapy was more effective than with metoprolol or ivabradine alone during the immediate postoperative management of cardiac surgery patients.,,,, +86,,,,,"During exercise, ivabradine dose dependently and significantly reduced the exercise-induced tachycardia (-17, -21, and -32% at 0.25, 0.5, and 1 mg/kg, respectively, versus saline) without altering myocardial contractility nor mean ejection wall stress.",,,, +87,,,,,Recent trials reported that risk of atrial fibrillation (AF) is increased in patients using ivabradine compared with controls.,,,, +88,,,,,Randomized comparative study of cefixime versus cephalexin in acute bacterial exacerbations of chronic bronchitis.,,,, +89,,,,,Alterations of the pilQ gene in Neisseria gonorrhoeae are unlikely contributors to decreased susceptibility to ceftriaxone and cefixime in clinical gonococcal strains.,,,, +90,,,,,"Because of the emergence of these bacteria, other antimicrobial agents, both old and new, have been advocated for treatment and prevention of otitis media; amoxicillin-clavulanate, cefuroxime axetil, and cefixime are the newer agents.",,,, +91,,,,,Experimental comparison of protective characteristics of enalapril and trimetazidine in diabetic nephropathy.,,,, +92,,,,,This study aimed to investigate the role of TMZ in diabetic nephropathy (DN) and its potential mechanisms.,,,, +93,,,,,Objective: This study investigates the effect of TMZ in sunitinib-induced cardiotoxicity in vivo and in vitro and molecular mechanisms.,,,, +94,,,,,The role of trimetazidine in cardiovascular disease: beyond an anti-anginal agent.,,,, +95,,,,,"Trimetazidine, 2.5 mg/kg/day i.p. for 3 days before doxorubicin administration plus 2.5 mg/kg/day p.o. for 10 weeks, was unable to prevent the development of doxorubicin-induced long-term cardiotoxicity.",,,, +96,,,,,Ranolazine was more effective than lidocaine in terminating persistent AF and in preventing the induction of AF.,,,, +97,,,,,Role of Ranolazine in cardiovascular disease and diabetes: Exploring beyond angina.,,,, +98,,,,,"Furthermore, the activated Akt/mTOR signaling pathway induced by AF was further activated by ranolazine.",,,, +99,,,,,Recent evidence of beneficial effects of ranolazine (RAN) in type II diabetes motivates interest in the role of the late sodium current (INaL) in glucose-stimulated insulin secretion.,,,, +100,,,,,Effect of ranolazine in preventing postoperative atrial fibrillation in patients undergoing coronary revascularization surgery.,,,, +101,,,,,The anti-ischemic mechanism of action of ranolazine in stable ischemic heart disease.,,,, +102,,,,,Atrial-selective/predominant sodium channel blockers such as ranolazine effectively suppress AF in experimental models of AF involving canine isolated right atrial preparations at concentrations that produce little to no effect on ventricular electrophysiologic parameters.,,,, +103,,,,,Ranolazine has been shown to decrease angina pectoris frequency and nitroglycerin consumption.,,,, +104,,,,,BACKGROUND: Ranolazine has been shown to reduce myocardial ischemia and symptom severity among selected patients with chronic angina.,,,, +105,,,,,"Dominant frequency (DF) of AF was reduced by ranolazine in left atrium from 11.7 (10.7-20.5) Hz to 7.6 (2.9-8.8) Hz (P = 0.02, n = 6).",,,, +106,,,,,"After adjusting for potential sources of bias through propensity-score matched-pair analysis and conditional logistic regression, ranolazine was an independent predictor of preventing POAF (p < 0.0001).",,,, +107,,,,,Prednisolone furthers T-cell immunodeficiency and also reduces the intensity of autoimmune reactions in multiple sclerosis.,,,, +108,,,,,[Pharmacokinetics of prednisolone in adrenal insufficiency ].,,,, +109,,,,,It is concluded that VAP is effective therapy in AIL.,,,, +110,,,,,A thermographic assessment of three intra-articular prednisolone analogues given in rheumatoid synovitis.,,,, +111,,,,,The effect of small doses of prednisolone on the incidence of subcutaneous sarcomas induced by 3-methylcholanthrene in virgin female Swiss mice.,,,, +112,,,,,[Effects of chromocarb diethylamine and prednisolone in experimental uveitis induced by clove oil in rabbits].,,,, +113,,,,,[Effect of prednisolone and heparin on circulating T- and B-lymphocytes in glomerulonephritis and systemic lupus erythematosus].,,,, +114,,,,,[Effects of prednisolone on thyroidal-123I uptake in subacute thyroiditis].,,,, +115,,,,,"Blood Eosinophil Depletion with Mepolizumab, Benralizumab and Prednisolone in Eosinophilic Asthma.",,,, +116,,,,,[Prednisolone and aspirin combination therapy in habitual abortion with autoantibodies].,,,, +117,,,,,"To illustrate this, we used an example of cost-effectiveness analysis for docetaxel in combination with prednisolone in metastatic hormone-refractory prostate cancer.",,,, +118,,,,,Prednisolone is associated with a worse bone mineral density in primary adrenal insufficiency.,,,, +119,,,,,CONCLUSIONS: Prednisolone was more effective in inducing response than itraconazole in acute-stage ABPA.,,,, +120,,,,,"Purpose: The aim of this study was to compare asparaginase-related toxicities in two asparaginase preparations, namely native Escherichia coli L-asparaginase (L-ASP) and pegylated asparaginase (PEG-ASP) in combination with ifosfamide, methotrexate, etoposide, and prednisolone (IMEP) in natural killer (NK)/T-cell lymphoma (NTCL).",,,, +121,,,,,Prednisolone combined with adjunctive immunosuppression is not superior to prednisolone alone in terms of efficacy and safety in giant cell arteritis: meta-analysis.,,,, +122,,,,,CONCLUSION: GVP is well-tolerated regimen with high response rate and needs to be tested in late relapsed HL.,,,, +123,,,,,Early treatment with addition of low dose prednisolone to methotrexate improves therapeutic outcome in severe psoriatic arthritis.,,,, +124,,,,,"CONCLUSION: Flu/Cy/ATG conditioning regimen, bone marrow as stem cell source and CSA, prednisolone and short methotrexate regimen were associated with better survival in AA.",,,, +125,,,,,Effect of addition of short course of prednisolone to gluten-free diet on mucosal epithelial cell regeneration and apoptosis in celiac disease: a pilot randomized controlled trial.,,,, +126,,,,,Coadministration of cyclosporin a with prednisolone in acute interstitial pneumonia complicating polymyositis/dermatomyositis.,,,, +127,,,,,"Efficacy of immunoglobulin plus prednisolone for prevention of coronary artery abnormalities in severe Kawasaki disease (RAISE study): a randomised, open-label, blinded-endpoints trial.",,,, +128,,,,,"Response of vincristine, melphalan, cyclophosphamide and prednisolone in refractory multiple myeloma.",,,, +129,,,,,Pyruvate kinase M2 and prednisolone resistance in acute lymphoblastic leukemia.,,,, +130,,,,,"Stimulation with prednisolone and TNFalpha reduced GDF-5 expression in OA and RA fibroblasts, whereas MTX and IL-1beta revealed minor or no relevant change.",,,, +131,,,,,"A combination of rituximab plus chemotherapy, rituximab+cyclophosphamide+doxorubicin+vincristine+prednisolone (R-CHOP), has the highest efficacy ever described with any chemotherapy in DLBCL and FL.",,,, 132,,,,,"A combination of rituximab plus chemotherapy, rituximab+cyclophosphamide+doxorubicin+vincristine+prednisolone (R-CHOP), has the highest efficacy ever described with any chemotherapy in DLBCL and FL.",,,, -133,,,,,"A combination of rituximab plus chemotherapy, rituximab+cyclophosphamide+doxorubicin+vincristine+prednisolone (R-CHOP), has the highest efficacy ever described with any chemotherapy in DLBCL and FL.",,,, -134,,,,,Weekly docetaxel and prednisolone versus prednisolone alone in androgen-independent prostate cancer: a randomized phase II study.,,,, -135,,,,,Prednisolone and azathioprine in membranous nephropathy: a 10-year follow-up study.,,,, -136,,,,,"Taken together, the present study points to a strong inhibitory effect of liposomal PLP on tumor angiogenesis by reduction of the intratumoral production of the majority of pro-angiogenic factors studied and direct inhibition of endothelial cell proliferation, which is the result of high prolonged levels of prednisolone in the tumor by liposomal delivery.",,,, -137,,,,,Prednisolone versus dexamethasone in croup: a randomised equivalence trial.,,,, -138,,,,,Use of ACTH and prednisolone in infantile spasms: experience from a developing country.,,,, -139,,,,,Bone mineral density in relation to efficacy and side effects of budesonide and prednisolone in Crohn's disease.,,,, -140,,,,,OBJECTIVE: To examine the safety and efficacy of methotrexate (MTX) plus low-dose prednisolone for induction of remission in non life- or organ-threatening courses and for remission maintenance in Churg-Strauss syndrome (CSS).,,,, -141,,,,,OBJECTIVE: To determine whether addition of low dose prednisolone to multidrug treatment can prevent reaction and nerve function impairment in leprosy.,,,, -142,,,,,A double-blind randomized controlled trial of infliximab associated with prednisolone in acute alcoholic hepatitis.,,,, -143,,,,,EULAR randomised controlled trial of pulse cyclophosphamide and methylprednisolone versus continuous cyclophosphamide and prednisolone followed by azathioprine and prednisolone in lupus nephritis.,,,, -144,,,,,OBJECTIVE: To investigate the safety and efficacy of leflunomide plus low-dose prednisolone for the maintenance of remission in Wegener's granulomatosis (WG).,,,, -145,,,,,"Treatment with combined therapy of adriamycin, vincristine and prednisolone produced a remission in the leukaemia with complete resolution of the breast mass.",,,, -146,,,,,RESULTS: The average initial dose of prednisolone in polymyalgia rheumatica was 35 mg; 51 of 62 patients were given a starting dose exceeding 15 mg.,,,, -147,,,,,[Trans-utero-tubal administration of prednisolone in sterility caused by obstruction of the tubes].,,,, -148,,,,,[On experiences with a combination preparation from prednisolone and an antihistaminic in dermatology especially in endogenous eczema].,,,, -149,,,,,[USE OF PREDNISOLONE IN SOME GRAVE FORMS OF PATHOLOGY OF THE PREMATURE INFANT].,,,, -150,,,,,[EFFECT OF PREDNISOLONE ON THE CARDIAC ACTIVITY IN LIVER AND KIDNEY DISEASES AND IN RHEUMATISM].,,,, -151,,,,,"In this limited pilot study, we compared the effect on clinical outcome of treating Pseudomonas keratitis in guinea pigs with prednisolone (a corticosteroid), flurbiprofen (a cyclo-oxygenase inhibitor), nordihydroguaiaretic acid (a lipoxygenase inhibitor), and a leukotriene antagonist, SKF104353 [R-(R*, S*)]-beta-[(2-carboxyethyl) thio-alpha-hydroxy-2-(8-phenyloctyl) benzenepropanoic acid, zinc salt].",,,, -152,,,,,URINARY EXCRETION OF PREDNISOLONE AFTER INTRARECTAL THERAPY IN ULCERATIVE COLITIS.,,,, -153,,,,,"Male rats treated with either budesonide, prednisolone, or triamcinolone acetonide in drinking water for up to 104 weeks developed slightly increased incidences of basophilic foci, and significantly increased incidences of combined hepatocellular adenomas/carcinomas as compared to controls.",,,, -154,,,,,[On the use of prednisolone in hemolytic anemia of the newborn caused by fetomaternal Rh-factor incompatibility].,,,, -155,,,,,Long-term use of prednisone and prednisolone in juvenile rheumatoid arthritis; a report of fifteen cases.,,,, -156,,,,,[Effect of prednisolone and human albumin on protein excretion in nephrotic syndrome].,,,, -157,,,,,[Therapeutic results of metacortandralone or prednisolone in allergy].,,,, -158,,,,,Primary resistance to vincristine (Vcr) and prednisolone in untreated AML was observed as well as 'acquired' resistance to several other antileukemic drugs.,,,, -159,,,,,"REPORT of the Committee on New Drugs of the Research Council of the American Academy of Allergy, 1955-56; studies on prednisone and prednisolone in ragweed pollinosis.",,,, -160,,,,,Effects of prednisone and prednisolone in ocular inflammation.,,,, -161,,,,,"Prednisolone scored better than prednisone in the categories of texture, taste, and aftertaste (p < 0.05); there was no statistical difference in smell.",,,, -162,,,,,Plasma prednisolone levels after administration of prednisolone-21-phosphate as a retention enema in colitis.,,,, -163,,,,,Mizoribine as an effective combined maintenance therapy with prednisolone in child-onset systemic lupus erythematosus.,,,, -164,,,,,Controlled prospective trial of prednisolone and cytotoxics in progressive IgA nephropathy.,,,, -165,,,,,"We propose that FE(NO) is associated with eosinophilic inflammation in children with difficult asthma, following prednisolone, and may help in identifying patients in whom persistent symptoms are associated with airway eosinophilia.",,,, -166,,,,,"Liposomal daunorubicin (DaunoXome) in combination with cyclophosphamide, vincristine and prednisolone (COP-X) as salvage therapy in poor-prognosis non-Hodgkins lymphoma.",,,, -167,,,,,Prednisolone in Duchenne muscular dystrophy.,,,, -168,,,,,Intravenous prednisolone in chronic bronchial asthma.,,,, -169,,,,,Reversibility with prednisolone is rarely seen in COPD.,,,, -170,,,,,"In spite of the fact that prednisolone-based treatment of pemphigus patients has proved to be effective in controlling the disease, some undesirable effects associated with this form of treatment have prompted investigation into other therapeutic approaches.",,,, -171,,,,,One reason for the good clinical effects of prednisolone in RA could be a down-regulation of adhesion and phagocytosis receptors on monocytes.,,,, -172,,,,,OBJECTIVE: To appraise the adjunctive role of prednisolone (PN) in pulmonary tuberculosis (PTB) with toxic reactions.,,,, -173,,,,,"A significant reduction of survival was found with the presence of permanent visual loss vs absence (p = 0.04), in patients who required more than 10 mg/d of glucocorticoid (p < 0.001) at 6 months treatment and in patients treated with prednisone (vs prednisolone) (p < 0.01).",,,, -174,,,,,"Fourteen patients developed hyperglycemia during induction therapy of acute lymphoblastic leukemia with L-asparaginase, prednisolone, vincristine and daunorubicin.",,,, -175,,,,,A 66-year-old man was treated for IgD (lambda) multiple myeloma with 2mg/day melphalan and 20mg/day prednisolone.,,,, -176,,,,,"Moreover, after recent findings regarding the presence of endogenous prednisolone in the urine of more popular breeds, particular attention was given to analysis of the presence of prednisolone and prednisone, as well.",,,, -177,,,,,"Of 10 mg of prednisone given orally to 5 normal subjects, 69+/-5% was absorbed and converted to peripheral plasma prednisolone within 8 h.",,,, -178,,,,,"As in humans, prednisolone was partly converted to prednisone in the rabbit.",,,, -179,,,,,"Given the close resemblance of the ring A structure of prednisolone and prednisone on the one hand, and of androstadienedione on the other, the transformation of cortisol and cortisone into prednisolone and prednisone in cattle faeces was evaluated.",,,, -180,,,,,The data indicate that prednisone is extensively metabolized to prednisolone before it clears the splanchnic circulation and the formation prednisone by oxidation of the 11-hydorxyl group of prednisolone appears to occur mainly in peripheral tissues.,,,, -181,,,,,CONCLUSION: Dexamethasone or prednisolone were the easiest to induce steroid glaucoma when the patients had long-term use of steroid eyedrops.,,,, -182,,,,,"Among 121 CK-analogs studied, CK-17, CK-101A and CK103A have been identified as promising anti-inflammatory agents as potent as prednisolone in inhibiting lens proteins-induced inflammation and twice as potent as prednisolone in inhibiting endotoxin-and IL-1-induced uveitis.",,,, -183,,,,,Light and electron microscopy of prednisolone-induced nephropathy in rabbits.,,,, -184,,,,,The behavior results showed that exposure to prednisolone resulted in decreased autonomic activity and low sensitivity to light.,,,, -185,,,,,We therefore advocate for increased clinical alertness towards prednisolone-induced adrenal insufficiency in RTx patients and thus their potential need of rescue GC supplementation during stress.,,,, -186,,,,,Zeaxanthin (50 mg/kg/day) or prednisolone (5 mg/kg/day) was orally administered for 14 days before induction of ulcerative colitis.,,,, -187,,,,,"OBJECTIVE: We want to show that an intralesional injection of prednisolone into the proximal nail fold may produce dorsal pain, dyspnoea and headaches within the 2 min following the injection and to explain the pathophysiology of his condition.",,,, -188,,,,,[A case of nephrotic syndrome with abnormally high level of protein C induced by prednisolone].,,,, -189,,,,,It is concluded that six or more cycles of COPP chemotherapy for advanced Hodgkin's disease in men leads to permanent sterility.,,,, -190,,,,,The erythroderma improved generally as a result of systemic prednisolone treatment.,,,, -191,,,,,CONTACT DERMATITIS DUE TO TOPICAL HYDROCORTISONE AND PREDNISOLONE.,,,, -192,,,,,[Pulmonary tuberculosis due to prednisolone].,,,, -193,,,,,"Rats were treated with a leukotriene synthesis inhibitor (PF-5901), a leukotriene B4 receptor antagonist (SC-41930), an IL-1 receptor antagonist or a corticosteroid (prednisolone) prior to induction of colitis.",,,, -194,,,,,"PURPOSE: To investigate the relationship between vitamin E deficiency and prednisolone-induced cataract formation, long-term examination of lens changes was performed in rats under the condition of vitamin E deficiency or supplementation and administration of prednisolone.",,,, -195,,,,,"In inactive SLE induced by prednisolone therapy, the invariant Valpha24JalphaQ TCR could be detected in DN Valpha24+ T cells from all the patients and dominated in most of the patients.",,,, -196,,,,,"Interleukin-1 (IL-1) blockers, CK 127 and CK 129, were found to inhibit IL-1-induced posterior uveitis very effectively at 3-10 mg/kg i.p. and were more potent than prednisolone which required at least 20 mg/kg i.p. to achieve the same level of anti-uveitis action.",,,, -197,,,,,[A case of hormone-refractory prostate cancer responsive to low-dose prednisolone therapy].,,,, -198,,,,,6 cases of FSGS had poor response to any therapy; 7 cases were responsive to either triple therapy or cyclosporine A plus prednisolone.,,,, -199,,,,,"From 1983, exacerbation of PIE was recorded three times, on which occasions prednisolone and antibiotics were quite effective.",,,, -200,,,,,"A comparative study of the effects of ACTH, hydrocortisone and prednisolone in the hypersensitive reactions produced with the protein components of Hymenolepis nana in albino mice.",,,, -201,,,,,"Immunosuppressant therapy, such as prednisolone or azathioprine, is considered for exacerbations of highly active glomerulonephritis.",,,, -202,,,,,"We describe a 57-year-old Caucasian male with anti-MDA5 positive dermatomyositis, that had a 4-month history of progressive dyspnoea requiring oxygen-therapy, scarcely responsive to prednisolone.",,,, -203,,,,,"After 14 months of treatment one of the patients developed severe, acute exacerbation of the ABPA and was treated with high-dose prednisolone and local steroid.",,,, -204,,,,,"The effect of pretreatment with topical prostaglandin E2, prednisolone and sulphasalazine in experimental colitis has been examined in the rat colon.",,,, -205,,,,,"Here, we report a case of prednisolone-dependent gastric sarcoidosis that improved after additional azathioprine, and also review the literature concerning the treatment, especially for prednisolone-dependent cases.",,,, -206,,,,,"METHODS: In 126 adults (33 healthy control subjects, 31 patients with mild asthma, 32 patients with severe asthma, and 30 patients with prednisolone-dependent asthma) parameters of inflammation (peripheral blood eosinophils and neutrophils) and markers of hemostasis (endogenous thrombin potential [ETP], thrombin-antithrombin complex, plasmin-alpha2-antiplasmin complex, plasminogen activator inhibitor type 1 [PAI-1], D-dimer, and von Willebrand factor [vWF]) were measured in plasma.",,,, -207,,,,,Previous studies from our laboratory revealed that coadministration of EP significantly increased the plasma concentration of prednisolone while decreased the level of cotreated prednisone in rats.,,,, -208,,,,,Metabolic effects of high-dose prednisolone treatment in early rheumatoid arthritis: balance between diabetogenic effects and inflammation reduction.,,,, -209,,,,,"Effects of prednisolone, salbutamol and theophylline on bronchial hyperreactivity and leucocyte chemokinesis in guinea pigs.",,,, -210,,,,,"This is the first case to support the beneficial effect of prednisolone in pericarditis with pSS, and illustrates its safety during pregnancy.",,,, -211,,,,,"When combined with environmental control, prednisolone and dexamethasone treatments had similar effects on heaves score, blood gases and endoscopic scores.",,,, -212,,,,,"Of the 20 patients, 14 initially received prednisolone treatment, which resulted in rapid improvement and normalization of eosinophilia within 8 weeks; however, 2 patients with splenomegaly showed poor control of eosinophilia in response to corticosteroid treatment.",,,, -213,,,,,Complement activation capacity in plasma before and during high-dose prednisolone treatment and tapering in exacerbations of Crohn's disease and ulcerative colitis.,,,, -214,,,,,Prednisolone-responsive headache in patients with solitary cysticercus granuloma and seizures.,,,, -215,,,,,"The patient was treated with chemotherapy by cyclophosphamide, hydroxydoxorubicin, vincristine and prednisolone (CHOP), however, it was ineffective, and the patient died of hemorrhage from the lymphoma involvement of the intestine 5 months after the onset of disease.",,,, -216,,,,,Effect of prednisolone in the experimentally induced nephropathy in male albino rats.,,,, -217,,,,,[On the effect of oral use of prednisolone on central chorioretinitis].,,,, -218,,,,,Peptic ulceration associated with prednisolone therapy.,,,, -219,,,,,"Glucocorticoids (e.g. prednisolone) are cornerstones in the treatment of acute exacerbations of ulcerative colitis (UC), and influence of the leucocyte/endothelial interaction appears to be part of their mode of action.",,,, -220,,,,,"Effects of honey, prednisolone, and disulfiram on inflammation, nitric oxide, and free radical formation.",,,, -221,,,,,OBJECTIVE: To assess the treatment effect of sodium hyaluronate (HA) on experimental temporomandibular joint (TMJ) osteoarthritis of rabbits in comparison with prednisolone (PS).,,,, -222,,,,,"ETO+PSL combination treatment, however, failed to show significant enhancement of anti-tumor effects.",,,, -223,,,,,"My- and My+ ALL did not significantly differ in sensitivity to prednisolone, dexamethasone, L-asparaginase and cytarabine.",,,, -224,,,,,"The dose of prednisolone was increased considering he was exacerbated of SLE, however, the convulsion as CNS lupus occurred to him.",,,, -225,,,,,"In a pilot study using one rabbit, prednisone and prednisolone clearance values increased with increase in either prednisone or prednisolone infusion rates.",,,, -226,,,,,"Budesonide is equal to less effective than prednisolone or prednisone therapy in the treatment of active Crohn's disease, but is associated with fewer glucocorticoids adverse reactions.",,,, -227,,,,,Diclofenac and prednisolone inhibit endotoxin-induced uveitis in rabbits.,,,, -228,,,,,"Although prednisolone and GH reverse hypoglycemia by different mechanisms, with only prednisolone suppressing tumor IGF-II secretion, both increase the formation of ternary IGF-IGFBP-3 complexes.",,,, -229,,,,,"The aqueous extract of Saiboku-to also showed an inhibition of the contact dermatitis, and it significantly potentiated the inhibition of contact dermatitis by prednisolone.",,,, -230,,,,,Only hydrocortisone and prednisolone suppressed LPS pneumonia.,,,, -231,,,,,"Prednisolone significantly inhibited the measurable sensitivity of IDT, while oclacitinib did not.",,,, -232,,,,,"A comparison with the bronchodilator potency of the above drugs indicated that in guinea pigs salbutamol appears relatively selective as a bronchodilator, prednisolone is selective as an inhibitor of eosinophilia whilst theophylline displays a balance of both activities.",,,, -233,,,,,Reduction of maintenance doses of prednisolone in bronchial asthma by the concurrent use of hydroxyzine.,,,, -234,,,,,"In contrast, cyclosporin A (CyA), FK-506 and prednisolone significantly inhibited antigen-induced airway inflammation and BHR in sensitized BN rats.",,,, -235,,,,,[Use of corticosteroids betamethasone and prednisolone in the prevention of allergic reactions in patients undergoing heart surgery with artificial blood circulation].,,,, -236,,,,,The intra-articular injection of prednisolone was shown to considerably reduce incidence of synovitis.,,,, -237,,,,,"Prednisolone (100 mg/die initially, decreasing doses thereafter) led to significant reduction of infiltrates and eosinophilia.",,,, -238,,,,,The tumour was significantly reduced by prednisolone.,,,, -239,,,,,"Prednisolone prevented the development of colitis, but had no effect on already-developed colitis.",,,, -240,,,,,Alveolar NO concentration was increased in patients with refractory asthma (7.1 ppb) compared with mild-to-moderate asthma (3.4 ppb) and normal controls (3.4 ppb) and reduced by treatment with prednisolone.,,,, -241,,,,,"Prednisolone treatment of sensory impairment of the ulnar and posterior tibial nerves detectable with the monofilament test, but not with the ballpen test, did not improve the long-term outcome in terms of recovery of touch sensibility, not did it reduce the risk of leprosy reactions or nerve function impairment beyond the initial 4-month treatment phase.",,,, -242,,,,,CONCLUSIONS: Predocol is an oral preparation of a poorly absorbed salt of prednisolone that is effective in reducing inflammation over short treatment periods in patients with active ulcerative colitis.,,,, -243,,,,,"Six weeks prior to his symptoms, prednisolone (PSL) and SASP had been started because of UC aggravation.",,,, -244,,,,,"When comparing organ specific, age-adjusted expected versus observed incidences after natural death of animals an increased tumor risk was found in organ systems of all treatment modalities but prednisolone.",,,, -245,,,,,"R-CHOP chemotherapy composed of rituximab, cyclophosphamide, adriamycin, vincristine, and prednisolone which might increase the risk of Pneumocystis pneumonia in patients with non-Hodgkin lymphoma.",,,, -246,,,,,"Cortisol deficiency is common in late stage HIV disease, but symptoms of fatigue and postural hypotension, as well as biochemical findings, are poor predictors of cortisol deficiency.",,,, -247,,,,,[Plasma cortisol and 17-ketosteroids in urine in relation to cardiac arrest].,,,, -248,,,,,"Independence of theta and TL surface antigens and killing by thymidine, cortisol, phytohemagglutinin, and cyclic AMP in a murine lymphoma.",,,, -249,,,,,"Furthermore, this treatment process demonstrated the superior anti-inflammatory effect of prednisolone over that of hydrocortisone and supported the assumption of inflammation related to CD.",,,, -250,,,,,"Ordinary least squared (OLS) regression was used to evaluate whether race moderated the associations between alcohol abuse and four biomarkers-urinary cortisol and serum dehydroepiandrosterone sulfate (DHEA-S), epinephrine and norepinephrine-and two composite summary scores, each consisting of two components that characterize the hypothalamic pituitary adrenal (HPA)-axis and sympathetic nervous systems (SNS), respectively.",,,, -251,,,,,"CONCLUSION: In patients with septic shock, low-dose hydrocortisone was associated with a lower risk of developing AF during the acute phase.",,,, -252,,,,,"The incidence of psychological symptoms as somatization, obsessive-compulsive symptoms, depression, anxiety, phobia, and nonspecific symptoms is statistically increased in pregnant women with elevated morning cortisol, but in women with elevated afternoon cortisol also occurring aggressiveness and paranoia.",,,, -253,,,,,How stress gets under the skin: cortisol and stress reactivity in psoriasis.,,,, -254,,,,,Absorption of hydrocortisone from the skin reservoir in atopic dermatitis.,,,, -255,,,,,OBJECTIVE: To assess dexamethasone (DEX) and hydrocortisone (HC) use in premature infants over time and the association of steroid use with the incidence of bronchopulmonary dysplasia (BPD) at 36 weeks' postmenstrual age.,,,, -256,,,,,Increased ratio of mRNA expression of the genes CYP17 and CYP11B1 indicates autonomous cortisol production in adrenocortical tumors.,,,, -257,,,,,"It is concluded that bile acids are potent endogenous inhibitors of 11 beta-HSD and, therefore, could participate in abnormalities of cortisol metabolism observed in liver cirrhosis and extrahepatic biliary obstruction and, possibly, after ingestion of bile acids.",,,, -258,,,,,"The plasma cortisol concentration was significantly higher in both DD groups before treatment than in the control group, and it decreased significantly after hoof trimming in the trimmed group.",,,, -259,,,,,Hydrocortisone in culture protects the blast cells in acute myeloblastic leukemia from the lethal effects of cytosine arabinoside.,,,, -260,,,,,Continuous subcutaneous hydrocortisone infusion in Addison's disease.,,,, -261,,,,,The current findings underline the relevance of cortisol and DHEA assessments and the need for further scrutiny of their interplay to foster our understanding of the biological basis of stress regulation in BPD.,,,, -262,,,,,"This hypoxia-specific increase in surface beta-adrenoreceptors was significantly enhanced in the cortisol-treated erythrocytes, showing that cortisol had a significant impact on erythrocyte beta-adrenoreceptor dynamics in addition to the direct influence of hypoxia.",,,, -263,,,,,"Congenital adrenal hyperplasia (CAH) due to deficiency of 21-hydroxylase is a disorder of the adrenal cortex characterised by cortisol deficiency, with or without aldosterone deficiency, and androgen excess.",,,, -264,,,,,"Changes of smoking behavior and serum adrenocorticotropic hormone, cortisol, prolactin, and endogenous opioids levels in nicotine dependence after naltrexone treatment.",,,, -265,,,,,We hypothesize that hydrocortisone infusion in severe community-acquired pneumonia attenuates systemic inflammation and leads to earlier resolution of pneumonia and a reduction in sepsis-related complications.,,,, -266,,,,,A prospective study was performed to investigate the combination of the aromatase inhibitor aminoglutethimide and hydrocortisone in androgen-independent prostate cancer with changes in prostate-specific antigen (PSA) level as main determinant for response.,,,, -267,,,,,"To investigate the time courses of the effects of the exogenous glucocorticoid agonists dexamethasone (DEX) and hydrocortisone (HYD) and a glucocorticoid antagonist (RU-38486), and to characterize the local and systemic responses in experimental AP.",,,, -268,,,,,[The adrenal cortex and hydrocortisone metabolism in experimental myocardial infarct].,,,, -269,,,,,[Intraarticular hydrocortisone (cortril) in arthritis and osteoarthritis].,,,, -270,,,,,[Use of cortisone and hydrocortisone in eye diseases].,,,, -271,,,,,[Topical use of hydrocortisone in otitis externa].,,,, -272,,,,,The use of hydrocortisone in ulcerative colitis: preliminary observations.,,,, -273,,,,,It can therefore be concluded that ointments containing either only E. coli BCS or a combination of BCS and hydrocortisone provide significant relief in perianal eczema as well as in early stages of hemorrhoidal disease.,,,, -274,,,,,The effect on cortisol supports the above conclusion and is consistent with HPA axis perturbation in opioid dependence as reported in other studies and extends these observations to stable methadone-maintained patients.,,,, -275,,,,,Several randomized controlled trials have evaluated the efficacy of a replacement therapy with hydrocortisone in severe sepsis.,,,, -276,,,,,[Diurnal variations in blood glucose and plasma cortisol in juvenile diabetes mellitus without ketoacidosis].,,,, -277,,,,,"OBJECTIVES: Elderly women with proximal femur fracture show abnormal persistence of increased cortisol concentrations, which could contribute to the high morbidity associated with this injury.",,,, -278,,,,,"From the compendium presented above, the following statements become evident: 1) Inappropriately low secretion of cortisol in relation to inflammation is a typical feature of the inflammatory disease in patients with RA.",,,, -279,,,,,Hydrocortisone infusion in septic shock differentially regulated the cytokine responses.,,,, -280,,,,,"BACKGROUND: There is substantial evidence of dysregulation of cortisol secretion, hippocampal abnormalities, and memory deficits in schizophrenia and other psychotic disorders.",,,, -281,,,,,(2) One of the mechanisms of therapeutic effect of cortisol in asthma might be its inhibitory effect on CA uptake.,,,, -282,,,,,"OBJECTIVE: To compare cortisol levels, diurnal cycles of cortisol, and reactivity of cortisol to psychological stress in fibromyalgia (FM) and rheumatoid arthritis (RA) patients in their natural environment, and to examine the effect on results of accounting for differences among the groups in psychological stress and other lifestyle and psychosocial variables.",,,, -283,,,,,"OBJECTIVES: Recent data suggest that higher plasma cortisol may be associated with hypertension and insulin resistance in otherwise healthy men, as it is in Cushing's syndrome.",,,, -284,,,,,"These findings demonstrate 2 types of adrenal insufficiency with different clinical pictures: Type 1 is characterized by cortisol deficiency with hypoglycaemia, low corticoid levels and a low cortisol secretion rate; Type 2 shows aldosterone deficiency with prominent salt loss.",,,, -285,,,,,"November, a period of reproductive quiescence in the southern hemisphere, with new antler growth and rapid weight gain, is associated with higher mean plasma cortisol concentrations and a greater responsiveness to exogenous ACTH.",,,, -286,,,,,Cortisol metabolism in human obesity: impaired cortisone-->cortisol conversion in subjects with central adiposity.,,,, -287,,,,,The hypothalamic-pituitary-adrenal (HPA) axis is one of the key physiological systems that counterbalances this systemic inflammation through changes in adrenocorticotrophic hormone (ACTH) and cortisol.,,,, -288,,,,,"The 5 dpf hypoxic exposure also elicited transient increases in whole body cortisol and in crf, uts1, and hsd20b2 expression, key regulators of the endocrine stress response.",,,, -289,,,,,"At multiple regression analyses, HOMA-IR on admission in the IR group significantly correlated with thyroid-stimulating hormone, glucagon, and cortisol.",,,, +133,,,,,Weekly docetaxel and prednisolone versus prednisolone alone in androgen-independent prostate cancer: a randomized phase II study.,,,, +134,,,,,Prednisolone and azathioprine in membranous nephropathy: a 10-year follow-up study.,,,, +135,,,,,"Taken together, the present study points to a strong inhibitory effect of liposomal PLP on tumor angiogenesis by reduction of the intratumoral production of the majority of pro-angiogenic factors studied and direct inhibition of endothelial cell proliferation, which is the result of high prolonged levels of prednisolone in the tumor by liposomal delivery.",,,, +136,,,,,Prednisolone versus dexamethasone in croup: a randomised equivalence trial.,,,, +137,,,,,Use of ACTH and prednisolone in infantile spasms: experience from a developing country.,,,, +138,,,,,Bone mineral density in relation to efficacy and side effects of budesonide and prednisolone in Crohn's disease.,,,, +139,,,,,OBJECTIVE: To examine the safety and efficacy of methotrexate (MTX) plus low-dose prednisolone for induction of remission in non life- or organ-threatening courses and for remission maintenance in Churg-Strauss syndrome (CSS).,,,, +140,,,,,OBJECTIVE: To determine whether addition of low dose prednisolone to multidrug treatment can prevent reaction and nerve function impairment in leprosy.,,,, +141,,,,,A double-blind randomized controlled trial of infliximab associated with prednisolone in acute alcoholic hepatitis.,,,, +142,,,,,EULAR randomised controlled trial of pulse cyclophosphamide and methylprednisolone versus continuous cyclophosphamide and prednisolone followed by azathioprine and prednisolone in lupus nephritis.,,,, +143,,,,,OBJECTIVE: To investigate the safety and efficacy of leflunomide plus low-dose prednisolone for the maintenance of remission in Wegener's granulomatosis (WG).,,,, +144,,,,,"Treatment with combined therapy of adriamycin, vincristine and prednisolone produced a remission in the leukaemia with complete resolution of the breast mass.",,,, +145,,,,,RESULTS: The average initial dose of prednisolone in polymyalgia rheumatica was 35 mg; 51 of 62 patients were given a starting dose exceeding 15 mg.,,,, +146,,,,,[Trans-utero-tubal administration of prednisolone in sterility caused by obstruction of the tubes].,,,, +147,,,,,[On experiences with a combination preparation from prednisolone and an antihistaminic in dermatology especially in endogenous eczema].,,,, +148,,,,,[USE OF PREDNISOLONE IN SOME GRAVE FORMS OF PATHOLOGY OF THE PREMATURE INFANT].,,,, +149,,,,,[EFFECT OF PREDNISOLONE ON THE CARDIAC ACTIVITY IN LIVER AND KIDNEY DISEASES AND IN RHEUMATISM].,,,, +150,,,,,"In this limited pilot study, we compared the effect on clinical outcome of treating Pseudomonas keratitis in guinea pigs with prednisolone (a corticosteroid), flurbiprofen (a cyclo-oxygenase inhibitor), nordihydroguaiaretic acid (a lipoxygenase inhibitor), and a leukotriene antagonist, SKF104353 [R-(R*, S*)]-beta-[(2-carboxyethyl) thio-alpha-hydroxy-2-(8-phenyloctyl) benzenepropanoic acid, zinc salt].",,,, +151,,,,,URINARY EXCRETION OF PREDNISOLONE AFTER INTRARECTAL THERAPY IN ULCERATIVE COLITIS.,,,, +152,,,,,"Male rats treated with either budesonide, prednisolone, or triamcinolone acetonide in drinking water for up to 104 weeks developed slightly increased incidences of basophilic foci, and significantly increased incidences of combined hepatocellular adenomas/carcinomas as compared to controls.",,,, +153,,,,,[On the use of prednisolone in hemolytic anemia of the newborn caused by fetomaternal Rh-factor incompatibility].,,,, +154,,,,,Long-term use of prednisone and prednisolone in juvenile rheumatoid arthritis; a report of fifteen cases.,,,, +155,,,,,[Effect of prednisolone and human albumin on protein excretion in nephrotic syndrome].,,,, +156,,,,,[Therapeutic results of metacortandralone or prednisolone in allergy].,,,, +157,,,,,Primary resistance to vincristine (Vcr) and prednisolone in untreated AML was observed as well as 'acquired' resistance to several other antileukemic drugs.,,,, +158,,,,,"REPORT of the Committee on New Drugs of the Research Council of the American Academy of Allergy, 1955-56; studies on prednisone and prednisolone in ragweed pollinosis.",,,, +159,,,,,Effects of prednisone and prednisolone in ocular inflammation.,,,, +160,,,,,"Prednisolone scored better than prednisone in the categories of texture, taste, and aftertaste (p < 0.05); there was no statistical difference in smell.",,,, +161,,,,,Plasma prednisolone levels after administration of prednisolone-21-phosphate as a retention enema in colitis.,,,, +162,,,,,Mizoribine as an effective combined maintenance therapy with prednisolone in child-onset systemic lupus erythematosus.,,,, +163,,,,,Controlled prospective trial of prednisolone and cytotoxics in progressive IgA nephropathy.,,,, +164,,,,,"We propose that FE(NO) is associated with eosinophilic inflammation in children with difficult asthma, following prednisolone, and may help in identifying patients in whom persistent symptoms are associated with airway eosinophilia.",,,, +165,,,,,"Liposomal daunorubicin (DaunoXome) in combination with cyclophosphamide, vincristine and prednisolone (COP-X) as salvage therapy in poor-prognosis non-Hodgkins lymphoma.",,,, +166,,,,,Prednisolone in Duchenne muscular dystrophy.,,,, +167,,,,,Intravenous prednisolone in chronic bronchial asthma.,,,, +168,,,,,Reversibility with prednisolone is rarely seen in COPD.,,,, +169,,,,,"In spite of the fact that prednisolone-based treatment of pemphigus patients has proved to be effective in controlling the disease, some undesirable effects associated with this form of treatment have prompted investigation into other therapeutic approaches.",,,, +170,,,,,One reason for the good clinical effects of prednisolone in RA could be a down-regulation of adhesion and phagocytosis receptors on monocytes.,,,, +171,,,,,OBJECTIVE: To appraise the adjunctive role of prednisolone (PN) in pulmonary tuberculosis (PTB) with toxic reactions.,,,, +172,,,,,"A significant reduction of survival was found with the presence of permanent visual loss vs absence (p = 0.04), in patients who required more than 10 mg/d of glucocorticoid (p < 0.001) at 6 months treatment and in patients treated with prednisone (vs prednisolone) (p < 0.01).",,,, +173,,,,,"Fourteen patients developed hyperglycemia during induction therapy of acute lymphoblastic leukemia with L-asparaginase, prednisolone, vincristine and daunorubicin.",,,, +174,,,,,A 66-year-old man was treated for IgD (lambda) multiple myeloma with 2mg/day melphalan and 20mg/day prednisolone.,,,, +175,,,,,"Moreover, after recent findings regarding the presence of endogenous prednisolone in the urine of more popular breeds, particular attention was given to analysis of the presence of prednisolone and prednisone, as well.",,,, +176,,,,,"Of 10 mg of prednisone given orally to 5 normal subjects, 69+/-5% was absorbed and converted to peripheral plasma prednisolone within 8 h.",,,, +177,,,,,"As in humans, prednisolone was partly converted to prednisone in the rabbit.",,,, +178,,,,,"Given the close resemblance of the ring A structure of prednisolone and prednisone on the one hand, and of androstadienedione on the other, the transformation of cortisol and cortisone into prednisolone and prednisone in cattle faeces was evaluated.",,,, +179,,,,,The data indicate that prednisone is extensively metabolized to prednisolone before it clears the splanchnic circulation and the formation prednisone by oxidation of the 11-hydorxyl group of prednisolone appears to occur mainly in peripheral tissues.,,,, +180,,,,,CONCLUSION: Dexamethasone or prednisolone were the easiest to induce steroid glaucoma when the patients had long-term use of steroid eyedrops.,,,, +181,,,,,"Among 121 CK-analogs studied, CK-17, CK-101A and CK103A have been identified as promising anti-inflammatory agents as potent as prednisolone in inhibiting lens proteins-induced inflammation and twice as potent as prednisolone in inhibiting endotoxin-and IL-1-induced uveitis.",,,, +182,,,,,Light and electron microscopy of prednisolone-induced nephropathy in rabbits.,,,, +183,,,,,The behavior results showed that exposure to prednisolone resulted in decreased autonomic activity and low sensitivity to light.,,,, +184,,,,,We therefore advocate for increased clinical alertness towards prednisolone-induced adrenal insufficiency in RTx patients and thus their potential need of rescue GC supplementation during stress.,,,, +185,,,,,Zeaxanthin (50 mg/kg/day) or prednisolone (5 mg/kg/day) was orally administered for 14 days before induction of ulcerative colitis.,,,, +186,,,,,"OBJECTIVE: We want to show that an intralesional injection of prednisolone into the proximal nail fold may produce dorsal pain, dyspnoea and headaches within the 2 min following the injection and to explain the pathophysiology of his condition.",,,, +187,,,,,[A case of nephrotic syndrome with abnormally high level of protein C induced by prednisolone].,,,, +188,,,,,It is concluded that six or more cycles of COPP chemotherapy for advanced Hodgkin's disease in men leads to permanent sterility.,,,, +189,,,,,The erythroderma improved generally as a result of systemic prednisolone treatment.,,,, +190,,,,,CONTACT DERMATITIS DUE TO TOPICAL HYDROCORTISONE AND PREDNISOLONE.,,,, +191,,,,,[Pulmonary tuberculosis due to prednisolone].,,,, +192,,,,,"Rats were treated with a leukotriene synthesis inhibitor (PF-5901), a leukotriene B4 receptor antagonist (SC-41930), an IL-1 receptor antagonist or a corticosteroid (prednisolone) prior to induction of colitis.",,,, +193,,,,,"PURPOSE: To investigate the relationship between vitamin E deficiency and prednisolone-induced cataract formation, long-term examination of lens changes was performed in rats under the condition of vitamin E deficiency or supplementation and administration of prednisolone.",,,, +194,,,,,"In inactive SLE induced by prednisolone therapy, the invariant Valpha24JalphaQ TCR could be detected in DN Valpha24+ T cells from all the patients and dominated in most of the patients.",,,, +195,,,,,"Interleukin-1 (IL-1) blockers, CK 127 and CK 129, were found to inhibit IL-1-induced posterior uveitis very effectively at 3-10 mg/kg i.p. and were more potent than prednisolone which required at least 20 mg/kg i.p. to achieve the same level of anti-uveitis action.",,,, +196,,,,,[A case of hormone-refractory prostate cancer responsive to low-dose prednisolone therapy].,,,, +197,,,,,6 cases of FSGS had poor response to any therapy; 7 cases were responsive to either triple therapy or cyclosporine A plus prednisolone.,,,, +198,,,,,"From 1983, exacerbation of PIE was recorded three times, on which occasions prednisolone and antibiotics were quite effective.",,,, +199,,,,,"A comparative study of the effects of ACTH, hydrocortisone and prednisolone in the hypersensitive reactions produced with the protein components of Hymenolepis nana in albino mice.",,,, +200,,,,,"Immunosuppressant therapy, such as prednisolone or azathioprine, is considered for exacerbations of highly active glomerulonephritis.",,,, +201,,,,,"We describe a 57-year-old Caucasian male with anti-MDA5 positive dermatomyositis, that had a 4-month history of progressive dyspnoea requiring oxygen-therapy, scarcely responsive to prednisolone.",,,, +202,,,,,"After 14 months of treatment one of the patients developed severe, acute exacerbation of the ABPA and was treated with high-dose prednisolone and local steroid.",,,, +203,,,,,"The effect of pretreatment with topical prostaglandin E2, prednisolone and sulphasalazine in experimental colitis has been examined in the rat colon.",,,, +204,,,,,"Here, we report a case of prednisolone-dependent gastric sarcoidosis that improved after additional azathioprine, and also review the literature concerning the treatment, especially for prednisolone-dependent cases.",,,, +205,,,,,"METHODS: In 126 adults (33 healthy control subjects, 31 patients with mild asthma, 32 patients with severe asthma, and 30 patients with prednisolone-dependent asthma) parameters of inflammation (peripheral blood eosinophils and neutrophils) and markers of hemostasis (endogenous thrombin potential [ETP], thrombin-antithrombin complex, plasmin-alpha2-antiplasmin complex, plasminogen activator inhibitor type 1 [PAI-1], D-dimer, and von Willebrand factor [vWF]) were measured in plasma.",,,, +206,,,,,Previous studies from our laboratory revealed that coadministration of EP significantly increased the plasma concentration of prednisolone while decreased the level of cotreated prednisone in rats.,,,, +207,,,,,Metabolic effects of high-dose prednisolone treatment in early rheumatoid arthritis: balance between diabetogenic effects and inflammation reduction.,,,, +208,,,,,"Effects of prednisolone, salbutamol and theophylline on bronchial hyperreactivity and leucocyte chemokinesis in guinea pigs.",,,, +209,,,,,"This is the first case to support the beneficial effect of prednisolone in pericarditis with pSS, and illustrates its safety during pregnancy.",,,, +210,,,,,"When combined with environmental control, prednisolone and dexamethasone treatments had similar effects on heaves score, blood gases and endoscopic scores.",,,, +211,,,,,"Of the 20 patients, 14 initially received prednisolone treatment, which resulted in rapid improvement and normalization of eosinophilia within 8 weeks; however, 2 patients with splenomegaly showed poor control of eosinophilia in response to corticosteroid treatment.",,,, +212,,,,,Complement activation capacity in plasma before and during high-dose prednisolone treatment and tapering in exacerbations of Crohn's disease and ulcerative colitis.,,,, +213,,,,,Prednisolone-responsive headache in patients with solitary cysticercus granuloma and seizures.,,,, +214,,,,,"The patient was treated with chemotherapy by cyclophosphamide, hydroxydoxorubicin, vincristine and prednisolone (CHOP), however, it was ineffective, and the patient died of hemorrhage from the lymphoma involvement of the intestine 5 months after the onset of disease.",,,, +215,,,,,Effect of prednisolone in the experimentally induced nephropathy in male albino rats.,,,, +216,,,,,[On the effect of oral use of prednisolone on central chorioretinitis].,,,, +217,,,,,Peptic ulceration associated with prednisolone therapy.,,,, +218,,,,,"Glucocorticoids (e.g. prednisolone) are cornerstones in the treatment of acute exacerbations of ulcerative colitis (UC), and influence of the leucocyte/endothelial interaction appears to be part of their mode of action.",,,, +219,,,,,"Effects of honey, prednisolone, and disulfiram on inflammation, nitric oxide, and free radical formation.",,,, +220,,,,,OBJECTIVE: To assess the treatment effect of sodium hyaluronate (HA) on experimental temporomandibular joint (TMJ) osteoarthritis of rabbits in comparison with prednisolone (PS).,,,, +221,,,,,"ETO+PSL combination treatment, however, failed to show significant enhancement of anti-tumor effects.",,,, +222,,,,,"My- and My+ ALL did not significantly differ in sensitivity to prednisolone, dexamethasone, L-asparaginase and cytarabine.",,,, +223,,,,,"The dose of prednisolone was increased considering he was exacerbated of SLE, however, the convulsion as CNS lupus occurred to him.",,,, +224,,,,,"In a pilot study using one rabbit, prednisone and prednisolone clearance values increased with increase in either prednisone or prednisolone infusion rates.",,,, +225,,,,,"Budesonide is equal to less effective than prednisolone or prednisone therapy in the treatment of active Crohn's disease, but is associated with fewer glucocorticoids adverse reactions.",,,, +226,,,,,Diclofenac and prednisolone inhibit endotoxin-induced uveitis in rabbits.,,,, +227,,,,,"Although prednisolone and GH reverse hypoglycemia by different mechanisms, with only prednisolone suppressing tumor IGF-II secretion, both increase the formation of ternary IGF-IGFBP-3 complexes.",,,, +228,,,,,"The aqueous extract of Saiboku-to also showed an inhibition of the contact dermatitis, and it significantly potentiated the inhibition of contact dermatitis by prednisolone.",,,, +229,,,,,Only hydrocortisone and prednisolone suppressed LPS pneumonia.,,,, +230,,,,,"Prednisolone significantly inhibited the measurable sensitivity of IDT, while oclacitinib did not.",,,, +231,,,,,"A comparison with the bronchodilator potency of the above drugs indicated that in guinea pigs salbutamol appears relatively selective as a bronchodilator, prednisolone is selective as an inhibitor of eosinophilia whilst theophylline displays a balance of both activities.",,,, +232,,,,,Reduction of maintenance doses of prednisolone in bronchial asthma by the concurrent use of hydroxyzine.,,,, +233,,,,,"In contrast, cyclosporin A (CyA), FK-506 and prednisolone significantly inhibited antigen-induced airway inflammation and BHR in sensitized BN rats.",,,, +234,,,,,[Use of corticosteroids betamethasone and prednisolone in the prevention of allergic reactions in patients undergoing heart surgery with artificial blood circulation].,,,, +235,,,,,The intra-articular injection of prednisolone was shown to considerably reduce incidence of synovitis.,,,, +236,,,,,"Prednisolone (100 mg/die initially, decreasing doses thereafter) led to significant reduction of infiltrates and eosinophilia.",,,, +237,,,,,The tumour was significantly reduced by prednisolone.,,,, +238,,,,,"Prednisolone prevented the development of colitis, but had no effect on already-developed colitis.",,,, +239,,,,,Alveolar NO concentration was increased in patients with refractory asthma (7.1 ppb) compared with mild-to-moderate asthma (3.4 ppb) and normal controls (3.4 ppb) and reduced by treatment with prednisolone.,,,, +240,,,,,"Prednisolone treatment of sensory impairment of the ulnar and posterior tibial nerves detectable with the monofilament test, but not with the ballpen test, did not improve the long-term outcome in terms of recovery of touch sensibility, not did it reduce the risk of leprosy reactions or nerve function impairment beyond the initial 4-month treatment phase.",,,, +241,,,,,CONCLUSIONS: Predocol is an oral preparation of a poorly absorbed salt of prednisolone that is effective in reducing inflammation over short treatment periods in patients with active ulcerative colitis.,,,, +242,,,,,"Six weeks prior to his symptoms, prednisolone (PSL) and SASP had been started because of UC aggravation.",,,, +243,,,,,"When comparing organ specific, age-adjusted expected versus observed incidences after natural death of animals an increased tumor risk was found in organ systems of all treatment modalities but prednisolone.",,,, +244,,,,,"R-CHOP chemotherapy composed of rituximab, cyclophosphamide, adriamycin, vincristine, and prednisolone which might increase the risk of Pneumocystis pneumonia in patients with non-Hodgkin lymphoma.",,,, +245,,,,,"Cortisol deficiency is common in late stage HIV disease, but symptoms of fatigue and postural hypotension, as well as biochemical findings, are poor predictors of cortisol deficiency.",,,, +246,,,,,[Plasma cortisol and 17-ketosteroids in urine in relation to cardiac arrest].,,,, +247,,,,,"Independence of theta and TL surface antigens and killing by thymidine, cortisol, phytohemagglutinin, and cyclic AMP in a murine lymphoma.",,,, +248,,,,,"Furthermore, this treatment process demonstrated the superior anti-inflammatory effect of prednisolone over that of hydrocortisone and supported the assumption of inflammation related to CD.",,,, +249,,,,,"Ordinary least squared (OLS) regression was used to evaluate whether race moderated the associations between alcohol abuse and four biomarkers-urinary cortisol and serum dehydroepiandrosterone sulfate (DHEA-S), epinephrine and norepinephrine-and two composite summary scores, each consisting of two components that characterize the hypothalamic pituitary adrenal (HPA)-axis and sympathetic nervous systems (SNS), respectively.",,,, +250,,,,,"CONCLUSION: In patients with septic shock, low-dose hydrocortisone was associated with a lower risk of developing AF during the acute phase.",,,, +251,,,,,"The incidence of psychological symptoms as somatization, obsessive-compulsive symptoms, depression, anxiety, phobia, and nonspecific symptoms is statistically increased in pregnant women with elevated morning cortisol, but in women with elevated afternoon cortisol also occurring aggressiveness and paranoia.",,,, +252,,,,,How stress gets under the skin: cortisol and stress reactivity in psoriasis.,,,, +253,,,,,Absorption of hydrocortisone from the skin reservoir in atopic dermatitis.,,,, +254,,,,,OBJECTIVE: To assess dexamethasone (DEX) and hydrocortisone (HC) use in premature infants over time and the association of steroid use with the incidence of bronchopulmonary dysplasia (BPD) at 36 weeks' postmenstrual age.,,,, +255,,,,,Increased ratio of mRNA expression of the genes CYP17 and CYP11B1 indicates autonomous cortisol production in adrenocortical tumors.,,,, +256,,,,,"It is concluded that bile acids are potent endogenous inhibitors of 11 beta-HSD and, therefore, could participate in abnormalities of cortisol metabolism observed in liver cirrhosis and extrahepatic biliary obstruction and, possibly, after ingestion of bile acids.",,,, +257,,,,,"The plasma cortisol concentration was significantly higher in both DD groups before treatment than in the control group, and it decreased significantly after hoof trimming in the trimmed group.",,,, +258,,,,,Hydrocortisone in culture protects the blast cells in acute myeloblastic leukemia from the lethal effects of cytosine arabinoside.,,,, +259,,,,,Continuous subcutaneous hydrocortisone infusion in Addison's disease.,,,, +260,,,,,The current findings underline the relevance of cortisol and DHEA assessments and the need for further scrutiny of their interplay to foster our understanding of the biological basis of stress regulation in BPD.,,,, +261,,,,,"This hypoxia-specific increase in surface beta-adrenoreceptors was significantly enhanced in the cortisol-treated erythrocytes, showing that cortisol had a significant impact on erythrocyte beta-adrenoreceptor dynamics in addition to the direct influence of hypoxia.",,,, +262,,,,,"Congenital adrenal hyperplasia (CAH) due to deficiency of 21-hydroxylase is a disorder of the adrenal cortex characterised by cortisol deficiency, with or without aldosterone deficiency, and androgen excess.",,,, +263,,,,,"Changes of smoking behavior and serum adrenocorticotropic hormone, cortisol, prolactin, and endogenous opioids levels in nicotine dependence after naltrexone treatment.",,,, +264,,,,,We hypothesize that hydrocortisone infusion in severe community-acquired pneumonia attenuates systemic inflammation and leads to earlier resolution of pneumonia and a reduction in sepsis-related complications.,,,, +265,,,,,A prospective study was performed to investigate the combination of the aromatase inhibitor aminoglutethimide and hydrocortisone in androgen-independent prostate cancer with changes in prostate-specific antigen (PSA) level as main determinant for response.,,,, +266,,,,,"To investigate the time courses of the effects of the exogenous glucocorticoid agonists dexamethasone (DEX) and hydrocortisone (HYD) and a glucocorticoid antagonist (RU-38486), and to characterize the local and systemic responses in experimental AP.",,,, +267,,,,,[The adrenal cortex and hydrocortisone metabolism in experimental myocardial infarct].,,,, +268,,,,,[Intraarticular hydrocortisone (cortril) in arthritis and osteoarthritis].,,,, +269,,,,,[Use of cortisone and hydrocortisone in eye diseases].,,,, +270,,,,,[Topical use of hydrocortisone in otitis externa].,,,, +271,,,,,The use of hydrocortisone in ulcerative colitis: preliminary observations.,,,, +272,,,,,It can therefore be concluded that ointments containing either only E. coli BCS or a combination of BCS and hydrocortisone provide significant relief in perianal eczema as well as in early stages of hemorrhoidal disease.,,,, +273,,,,,The effect on cortisol supports the above conclusion and is consistent with HPA axis perturbation in opioid dependence as reported in other studies and extends these observations to stable methadone-maintained patients.,,,, +274,,,,,Several randomized controlled trials have evaluated the efficacy of a replacement therapy with hydrocortisone in severe sepsis.,,,, +275,,,,,[Diurnal variations in blood glucose and plasma cortisol in juvenile diabetes mellitus without ketoacidosis].,,,, +276,,,,,"OBJECTIVES: Elderly women with proximal femur fracture show abnormal persistence of increased cortisol concentrations, which could contribute to the high morbidity associated with this injury.",,,, +277,,,,,"From the compendium presented above, the following statements become evident: 1) Inappropriately low secretion of cortisol in relation to inflammation is a typical feature of the inflammatory disease in patients with RA.",,,, +278,,,,,Hydrocortisone infusion in septic shock differentially regulated the cytokine responses.,,,, +279,,,,,"BACKGROUND: There is substantial evidence of dysregulation of cortisol secretion, hippocampal abnormalities, and memory deficits in schizophrenia and other psychotic disorders.",,,, +280,,,,,(2) One of the mechanisms of therapeutic effect of cortisol in asthma might be its inhibitory effect on CA uptake.,,,, +281,,,,,"OBJECTIVE: To compare cortisol levels, diurnal cycles of cortisol, and reactivity of cortisol to psychological stress in fibromyalgia (FM) and rheumatoid arthritis (RA) patients in their natural environment, and to examine the effect on results of accounting for differences among the groups in psychological stress and other lifestyle and psychosocial variables.",,,, +282,,,,,"OBJECTIVES: Recent data suggest that higher plasma cortisol may be associated with hypertension and insulin resistance in otherwise healthy men, as it is in Cushing's syndrome.",,,, +283,,,,,"These findings demonstrate 2 types of adrenal insufficiency with different clinical pictures: Type 1 is characterized by cortisol deficiency with hypoglycaemia, low corticoid levels and a low cortisol secretion rate; Type 2 shows aldosterone deficiency with prominent salt loss.",,,, +284,,,,,"November, a period of reproductive quiescence in the southern hemisphere, with new antler growth and rapid weight gain, is associated with higher mean plasma cortisol concentrations and a greater responsiveness to exogenous ACTH.",,,, +285,,,,,Cortisol metabolism in human obesity: impaired cortisone-->cortisol conversion in subjects with central adiposity.,,,, +286,,,,,The hypothalamic-pituitary-adrenal (HPA) axis is one of the key physiological systems that counterbalances this systemic inflammation through changes in adrenocorticotrophic hormone (ACTH) and cortisol.,,,, +287,,,,,"The 5 dpf hypoxic exposure also elicited transient increases in whole body cortisol and in crf, uts1, and hsd20b2 expression, key regulators of the endocrine stress response.",,,, +288,,,,,"At multiple regression analyses, HOMA-IR on admission in the IR group significantly correlated with thyroid-stimulating hormone, glucagon, and cortisol.",,,, +289,,,,,"The suppression of the anti-inflammatory effects of cortisol as a result of states of excessive stress leads to hypercatabolic diseases such as AIDS, sepsis and toxic shock syndrome and protein calorie malnutrition (NAIDS).",,,, 290,,,,,"The suppression of the anti-inflammatory effects of cortisol as a result of states of excessive stress leads to hypercatabolic diseases such as AIDS, sepsis and toxic shock syndrome and protein calorie malnutrition (NAIDS).",,,, -291,,,,,"The suppression of the anti-inflammatory effects of cortisol as a result of states of excessive stress leads to hypercatabolic diseases such as AIDS, sepsis and toxic shock syndrome and protein calorie malnutrition (NAIDS).",,,, -292,,,,,"We report the case of a 41-year-old nonatopic women with a previous history of eczematous reaction due to hydrocortisone who suffered worsening of her perennial rhinitis in association with perinasal dermatitis from the use of budesonide in nasal spray form, and stomatitis and pharyngitis due to budesonide in a bronchial inhaler.",,,, -293,,,,,"In this perspective paper, we focus on the neuro-endocrine interactions that occur between progesterone, allopregnanolone, and cortisol during pregnancy, and propose that they align with our previously proposed model of FM pathogenesis based on GABAergic ""weakening"" in a thalamocortical neural loop system.",,,, -294,,,,,The present study reported a case of hydrocortisone-induced blood pressure reduction in a patient with anterior pituitary hypofunction due to allergic reaction.,,,, -295,,,,,Fetal adrenocorticotropic hormone and cortisol increased to peak values within 2.8 hours of induced hypoxia but by 7.2 hours had begun to fall to values that were not significantly different from those at 1.4 hours.,,,, -296,,,,,Congenital adrenal hyperplasia (CAH) is a chronic condition and individuals are exposed to elevated androgen levels in utero as a result of the endogenous cortisol deficiency.,,,, -297,,,,,The results of our study confirm that thymol has strong ameliorative effect against hydrocortisone-induced oxidative stress injury in hepatic tissues.,,,, -298,,,,,The effects of 8-bromo-cyclic AMP and cyclic AMP agonists (cholera toxin plus hydrocortisone and prostaglandin E2 plus 3-isobutyl-1-methylxanthine) on the cytotoxic activity of T cells generated during murine influenza virus infection have been examined.,,,, -299,,,,,Open oral provocation with 100 or 250 mg hydrocortisone in patients with hydrocortisone contact hypersensitivity elicited cutaneous reactions at sites of previous allergic dermatitis caused by hydrocortisone in two patients and at sites of earlier allergic patch test reactions caused by hydrocortisone in the other two patients.,,,, -300,,,,,"Although initial studies in transgenic mice and humans are encouraging, more data are required to conclusively prove the hypothesis that the adipose-tissue-specific overexpression of HSD1 and the resultant increase in tissue-specific cortisol concentrations result in human obesity, insulin resistance, high blood pressure, and metabolic syndrome.",,,, -301,,,,,"CONCLUSION: Although hydrocortisone has anti-inflammatory properties, it seems to provoke inflammation in the round window membrane after topical instillation.",,,, -302,,,,,"Type 2 glucocorticoid receptors (GRs), which are occupied by cortisol in humans in times of stress, are thought to be responsible for the glucocorticoid-induced memory impairment.",,,, -303,,,,,"Firstly, the GH-mediated increase in cortisol metabolism (mediated via reduced E to F conversion) may precipitate adrenal insufficiency in hypopituitary patients with partial adrenocorticotropic hormone deficiency commencing GH therapy.",,,, -304,,,,,"From this study it is inferred that the group III steroid betamethasone dipropionate alone heals experimentally induced external otitis more rapidly than hydrocortisone with oxytetracycline, with or without polymyxin B.",,,, -305,,,,,"In conclusion, the reciprocal expression of CYP17 and the transcriptional repressors COUP-TF and DAX-1 indicates that these orphan receptors have a pathophysiologic role in the excessive hormone production in cortisol- and deoxycorticosterone-producing adrenocortical tumors.",,,, -306,,,,,"The administration of hydrocortisone before tumor inoculation resulted in increased tumor take, reduced mean survival time of mice, and concentration of tumor metastasis in a specific organ (i.e., lung metastasis for Ehrlich hypotetraploid clone 1 tumor, and liver metastasis for Ehrlich hypotetraploid stock and Ehrlich hyperdiploid stock tumors).",,,, -307,,,,,"Cortisol counteracts the insulin activation of glycogen synthase in muscle, the insulin inhibition of hepatic glucose production and the insulin inhibition of lipolysis in adipose tissue, leading to the well-established systemic insulin resistance caused by excess cortisol.",,,, -308,,,,,"The amount of N-acetyl D-glucosamine in the zymogen granule membrane was not altered by caerulein acute pancreatitis induced under continuous hydrocortisone treatment, but it was decreased by the administration of L-364,718 over 7 days after pancreatitis induction.",,,, -309,,,,,False elevation of plasma cortisol in congenital adrenal hyperplasia.,,,, -310,,,,,Further studies evaluating the mechanism of action and long term effects of hydrocortisone in cardiac arrest need to be conducted.,,,, -311,,,,,"In acute MI, there were elevated plasma levels of cortisol depending on the MI severity with a small repeated peak of its increase on day 14 and its subsequent decrease, except deaths.",,,, -312,,,,,"Aldosterone levels, like cortisol, have been shown to be increased in sepsis and hemorrhagic shock.",,,, -313,,,,,"In this review, we summarize the effects of circadian melatonin, TSH, and cortisol on OA, focusing on how different levels of these hormones affect OA pathogenesis and recovery with respect to the circadian clock.",,,, -314,,,,,"There may be a subset of patients unable to elicit an appropriate immunosuppressive response to stress through upregulation of cortisol, with resultant exacerbation of their psoriasis.",,,, -315,,,,,"In addition to local effect, topical hydrocortisone therapy of childhood dermatitis is accompanied by a systemic effect that may be pronounced in the acute phase of disease.",,,, -316,,,,,"They answered the Fibromyalgia Impact Questionnaire (FIQ), Perceived Stress Questionnaire (PSQ) and McGill Pain Questionnaire (MPQ-Br), and collected saliva to evaluate CC before and after the end of each month.",,,, -317,,,,,"BACKGROUND: The hypothalamic-pituitary-adrenal stress axis plays a crucial role in community-acquired pneumonia (CAP), with high cortisol being associated with disease severity and corticosteroid treatment resulting in earlier time to recovery.",,,, -318,,,,,"The incidence of AF was compared among patients who received hydrocortisone, and the effect of low-dose hydrocortisone on AF was estimated using the inverse probability treatment weighting method based on propensity scores.",,,, +291,,,,,"We report the case of a 41-year-old nonatopic women with a previous history of eczematous reaction due to hydrocortisone who suffered worsening of her perennial rhinitis in association with perinasal dermatitis from the use of budesonide in nasal spray form, and stomatitis and pharyngitis due to budesonide in a bronchial inhaler.",,,, +292,,,,,"In this perspective paper, we focus on the neuro-endocrine interactions that occur between progesterone, allopregnanolone, and cortisol during pregnancy, and propose that they align with our previously proposed model of FM pathogenesis based on GABAergic ""weakening"" in a thalamocortical neural loop system.",,,, +293,,,,,The present study reported a case of hydrocortisone-induced blood pressure reduction in a patient with anterior pituitary hypofunction due to allergic reaction.,,,, +294,,,,,Fetal adrenocorticotropic hormone and cortisol increased to peak values within 2.8 hours of induced hypoxia but by 7.2 hours had begun to fall to values that were not significantly different from those at 1.4 hours.,,,, +295,,,,,Congenital adrenal hyperplasia (CAH) is a chronic condition and individuals are exposed to elevated androgen levels in utero as a result of the endogenous cortisol deficiency.,,,, +296,,,,,The results of our study confirm that thymol has strong ameliorative effect against hydrocortisone-induced oxidative stress injury in hepatic tissues.,,,, +297,,,,,The effects of 8-bromo-cyclic AMP and cyclic AMP agonists (cholera toxin plus hydrocortisone and prostaglandin E2 plus 3-isobutyl-1-methylxanthine) on the cytotoxic activity of T cells generated during murine influenza virus infection have been examined.,,,, +298,,,,,Open oral provocation with 100 or 250 mg hydrocortisone in patients with hydrocortisone contact hypersensitivity elicited cutaneous reactions at sites of previous allergic dermatitis caused by hydrocortisone in two patients and at sites of earlier allergic patch test reactions caused by hydrocortisone in the other two patients.,,,, +299,,,,,"Although initial studies in transgenic mice and humans are encouraging, more data are required to conclusively prove the hypothesis that the adipose-tissue-specific overexpression of HSD1 and the resultant increase in tissue-specific cortisol concentrations result in human obesity, insulin resistance, high blood pressure, and metabolic syndrome.",,,, +300,,,,,"CONCLUSION: Although hydrocortisone has anti-inflammatory properties, it seems to provoke inflammation in the round window membrane after topical instillation.",,,, +301,,,,,"Type 2 glucocorticoid receptors (GRs), which are occupied by cortisol in humans in times of stress, are thought to be responsible for the glucocorticoid-induced memory impairment.",,,, +302,,,,,"Firstly, the GH-mediated increase in cortisol metabolism (mediated via reduced E to F conversion) may precipitate adrenal insufficiency in hypopituitary patients with partial adrenocorticotropic hormone deficiency commencing GH therapy.",,,, +303,,,,,"From this study it is inferred that the group III steroid betamethasone dipropionate alone heals experimentally induced external otitis more rapidly than hydrocortisone with oxytetracycline, with or without polymyxin B.",,,, +304,,,,,"In conclusion, the reciprocal expression of CYP17 and the transcriptional repressors COUP-TF and DAX-1 indicates that these orphan receptors have a pathophysiologic role in the excessive hormone production in cortisol- and deoxycorticosterone-producing adrenocortical tumors.",,,, +305,,,,,"The administration of hydrocortisone before tumor inoculation resulted in increased tumor take, reduced mean survival time of mice, and concentration of tumor metastasis in a specific organ (i.e., lung metastasis for Ehrlich hypotetraploid clone 1 tumor, and liver metastasis for Ehrlich hypotetraploid stock and Ehrlich hyperdiploid stock tumors).",,,, +306,,,,,"Cortisol counteracts the insulin activation of glycogen synthase in muscle, the insulin inhibition of hepatic glucose production and the insulin inhibition of lipolysis in adipose tissue, leading to the well-established systemic insulin resistance caused by excess cortisol.",,,, +307,,,,,"The amount of N-acetyl D-glucosamine in the zymogen granule membrane was not altered by caerulein acute pancreatitis induced under continuous hydrocortisone treatment, but it was decreased by the administration of L-364,718 over 7 days after pancreatitis induction.",,,, +308,,,,,False elevation of plasma cortisol in congenital adrenal hyperplasia.,,,, +309,,,,,Further studies evaluating the mechanism of action and long term effects of hydrocortisone in cardiac arrest need to be conducted.,,,, +310,,,,,"In acute MI, there were elevated plasma levels of cortisol depending on the MI severity with a small repeated peak of its increase on day 14 and its subsequent decrease, except deaths.",,,, +311,,,,,"Aldosterone levels, like cortisol, have been shown to be increased in sepsis and hemorrhagic shock.",,,, +312,,,,,"In this review, we summarize the effects of circadian melatonin, TSH, and cortisol on OA, focusing on how different levels of these hormones affect OA pathogenesis and recovery with respect to the circadian clock.",,,, +313,,,,,"There may be a subset of patients unable to elicit an appropriate immunosuppressive response to stress through upregulation of cortisol, with resultant exacerbation of their psoriasis.",,,, +314,,,,,"In addition to local effect, topical hydrocortisone therapy of childhood dermatitis is accompanied by a systemic effect that may be pronounced in the acute phase of disease.",,,, +315,,,,,"They answered the Fibromyalgia Impact Questionnaire (FIQ), Perceived Stress Questionnaire (PSQ) and McGill Pain Questionnaire (MPQ-Br), and collected saliva to evaluate CC before and after the end of each month.",,,, +316,,,,,"BACKGROUND: The hypothalamic-pituitary-adrenal stress axis plays a crucial role in community-acquired pneumonia (CAP), with high cortisol being associated with disease severity and corticosteroid treatment resulting in earlier time to recovery.",,,, +317,,,,,"The incidence of AF was compared among patients who received hydrocortisone, and the effect of low-dose hydrocortisone on AF was estimated using the inverse probability treatment weighting method based on propensity scores.",,,, +318,,,,,"INTRODUCTION: Intrathecal administration of methotrexate, cytarabine, and hydrocortisone is commonly used to treat and prevent central nervous system involvement in leukemias and lymphomas.",,,, 319,,,,,"INTRODUCTION: Intrathecal administration of methotrexate, cytarabine, and hydrocortisone is commonly used to treat and prevent central nervous system involvement in leukemias and lymphomas.",,,, -320,,,,,"INTRODUCTION: Intrathecal administration of methotrexate, cytarabine, and hydrocortisone is commonly used to treat and prevent central nervous system involvement in leukemias and lymphomas.",,,, -321,,,,,"CONCLUSIONS: Early PN did not affect plasma concentrations of ACTH and (free) cortisol, but increased the incidence of septic shock, which statistically explained why more patients on early PN received corticosteroids.",,,, -322,,,,,"Sixteen reacted to tixocortol pivalate and also to other corticosteroids, particularly to hydrocortisone, which could explain exacerbations of eczema in these cases.",,,, -323,,,,,"Finally, transient pre-treatment of healthy humans with cortisol induces a bi-phasic response during a later, delayed systemic inflammatory response: an intermediate cortisol concentration augments inflammation while a high cortisol concentration is neither pro- nor anti-inflammatory.",,,, -324,,,,,"Adrenaline induces the early posthypoglycaemic insulin resistance, whereas cortisol and growth hormone are important for the insulin resistance that is observed later following hypoglycaemia.",,,, -325,,,,,"RESULTS: Within 24 hours following TBI, the concentrations of total cortisol, ACTH and gastrin increased proportionally to the severity of injury, especially significant in the experimental group (P less than 0.05).",,,, -326,,,,,NEW OR UNIQUE INFORMATION PROVIDED: This case is the first published report of hydrocortisone-responsive hypotension and transient CIRCI associated with naturally occurring septic shock in a dog.,,,, -327,,,,,Several types of the congenital adrenal hyperplasias are associated with decreased cortisol production and excessive adrenal sex steroid secretion.,,,, -328,,,,,[Use of cryo-apheresis in the treatment of patients with cortisol-dependent bronchial asthma].,,,, -329,,,,,Hypotension after recruitment was reduced by HC (0 vs. 30%).,,,, -330,,,,,Fetal plasma cortisol concentrations were increased ( P < 0.05) during all levels of hypoxia.,,,, -331,,,,,"INTRA-CELL CORTISOL: Attention is also focused on the potential implication of cortisol in the genesis of metabolic syndrome, because cortisol is a potent antagonist of the effect of insulin and its presence in excess enhances visceral obesity and insulin resistance.",,,, -332,,,,,The effect of hydrocortisone on standardized skin-surface trauma.,,,, -333,,,,,The action of hydrocortisone in synovial inflammation.,,,, -334,,,,,"The effects of stressful life events, coping, and cortisol on HIV infection.",,,, -335,,,,,"Immunologic and hemodynamic effects of ""low-dose"" hydrocortisone in septic shock: a double-blind, randomized, placebo-controlled, crossover study.",,,, -336,,,,,"To prolong the anti-tumor effect some mice were also given cyclophosphamide, hydrocortisone, or a second injection of virus.",,,, -337,,,,,"In conclusion, HRT in postmenopausal asthmatic women has a favorable influence on the course of asthma, reduces daily use of glucocorticosteroids and frequency of asthma exacerbations and normalizes serum concentrations of estradiol, cortisol and DHEAS, which were decreased before HRT.",,,, -338,,,,,"However, after adjusting for the effect of obesity by multiple regression, higher plasma cortisol was independently associated with higher diastolic blood pressure in men (r = 0.21, P = 0.04) but not in women, and higher fasting serum triglyceride levels in women (r = 0.28, P < 0. 001) but not in men.",,,, -339,,,,,"ii) Reduction of cortisone to cortisol in the liver may increase insulin resistance in type 2 diabetes mellitus, and inhibition of the enzyme may lead to a decrease in gluconeogenesis.",,,, -340,,,,,"Pretreatment of rats with hydrocortisone or protamin-Zn-insulin within 4 days altered in subsequent acute hypoxia (3 hrs, ""height"" 10 000 m) the isoenzyme spectrum of LDH in lungs, liver tissue and kidney cortex.",,,, -341,,,,,Previously we related persistent cortisol increases to memory impairments in elderly humans studied over five years.,,,, -342,,,,,It was suggested that the progressive shift from type 1 to type 2 cytokine production characteristic of HIV infection could be at least partially provoked by the increase in the production of cortisol and the reduction of DHEA.,,,, -343,,,,,CONCLUSIONS: This study suggests that 24 h urinary free cortisol could be considered as a potential index of adrenal cortisol production in patients with liver cirrhosis and it potentially detects patients with a high mortality risk.,,,, -344,,,,,Congenital adrenal hyperplasia (CAH) is an autosomal recessive disorder that leads to the partial or complete deficiency of cortisol and aldosterone production from the adrenal glands.,,,, -345,,,,,[Reaction of autogenous cortisol production in patients with extensive psoriasis vulgaris or atopic dermatitis following external administration of a 0.25% prednicarbate salve (W/O emulsion)].,,,, -346,,,,,"OBJECTIVE: Corticosteroid-binding globulin (CBG), the cortisol transport protein, is cleaved from high-affinity (haCBG) to low-affinity (laCBG) CBG at sites of inflammation releasing bioavailable, anti-inflammatory cortisol.",,,, -347,,,,,The propensity to develop type 1 diabetes or type 2 diabetes/metabolic syndrome depends on the propensity to release of cortisol which correlates with race.,,,, -348,,,,,"CIRCI is characterized by an inadequate production of cortisol in relation to an increased demand during periods of severe stress, particularly in critical illnesses such as sepsis or septic shock.",,,, -349,,,,,Synacthen test diagnosed Addison's disease with a clear deficiency of cortisol production.,,,, -350,,,,,"Enhanced cortisol production rates, free cortisol, and 11beta-HSD-1 expression correlate with visceral fat and insulin resistance in men: effect of weight loss.",,,, -351,,,,,"Obesity is also related to dysregulation of cortisol production by the pre-receptor enzyme, 11beta-hydroxysteroid dehydrogenase, and we speculate that this may have a role in the pathogenesis of obesity and raised ICP seen in IIH.",,,, -352,,,,,"This is an extremely rare case of bilateral adrenal tumors, in which the left adrenocortical tumor produced and secreted cortisol or both cortisol and aldosterone and the right one produced and secreted both aldosterone and cortisol, as confirmed by clinical findings and pathological studies using immunohistochemical analysis.",,,, -353,,,,,"We conclude that the clinical picture of late-onset adrenal insufficiency in preterm infants is not a result of an absolute deficiency of cortisol production, but may be a result of a limited ability to synthesize sufficient cortisol for the degree of clinical stress.",,,, -354,,,,,"Ironically, despite our understanding of the various stressors that promote chronic adult-onset asthma, most of which are known to elevate cortisol production via the hypothalamic-pituitary-adrenal (HPA) axis, inhaled and systemic corticosteroids are the mainstay for the treatment of chronic asthma.",,,, -355,,,,,Glucocorticoid insufficiency is common during sepsis and may result from insufficient production of cortisol or peripheral tissues resistance.,,,, -356,,,,,"This likely represents an adaptive response to LTH, to prevent excessive cortisol production that would restrict fetal growth and potentially induce preterm delivery.",,,, -357,,,,,"The reduction in local cortisol production which diminishes the endogenous anti-inflammatory effects, also allows for the progression of both vascular and pulmonary inflammation.",,,, -358,,,,,"CONCLUSIONS: Patients with newly diagnosed, untreated PC yielded significantly higher cortisol and lower estradiol serum concentrations than controls.",,,, -359,,,,,"The tumour secreted excessive cortisol and dehydroepiandrosterone-sulphate (DHEA-S), and had invaded the right hepatic lobe and vena cava.",,,, -360,,,,,Replacement doses of hydrocortisone were administered throughout treatment to counteract potential adrenal insufficiency secondary to the ketoconazole.,,,, -361,,,,,Amplication by hydrocortisone of the induction of cytotoxic response in vitro to syngeneic murine leukemias.,,,, -362,,,,,The results demonstrated that the intrarectal dose of indomethacin and hydrocortisone inhibited the development of tumors from microscopic carcinoma lesions in the large bowel and growing further.,,,, -363,,,,,"Growth of ovarian, lung, breast, and kidney carcinomas was increased by 136%, 126%, 78% and 69%, respectively, whereas melanomas, sarcomas, and colon tumors were inhibited by hydrocortisone.",,,, -364,,,,,Insufficient cortisol limits the ability of the sick newborn to handle stress and inhibit pulmonary inflammation.,,,, -365,,,,,"BACKGROUND: Hepatic 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) activity, which converts cortisone (inactive) to cortisol, is downregulated in obesity.",,,, -366,,,,,"High-dose hydrocortisone treatment given in the first few hours after a traumatic experience was associated with significant favorable changes in the trajectory of exposure to trauma, as expressed by the reduced risk of the development of PTSD post-trauma.",,,, -367,,,,,"Under normal conditions, stress induces increased cortisol secretion that counteracts inflammatory reactions.",,,, -368,,,,,Hydrocortisone (HC) reduced the macrophage content of four murine tumors to less than half of control values.,,,, -369,,,,,"Further, because infant formula contains only trace amounts of glucocorticoids, these findings suggest that cortisol in milk is a novel biological pathway through which breastfeeding may protect against later obesity.",,,, -370,,,,,"Conclusions and Relevance: Among adults with severe sepsis not in septic shock, use of hydrocortisone compared with placebo did not reduce the risk of septic shock within 14 days.",,,, -371,,,,,These findings suggest that HC may protect against hyperoxic injury in the developing pulmonary vasculature.,,,, -372,,,,,OBJECTIVE: Cortisol clearance is reduced in sepsis and may contribute to the development of impaired adrenocortical function that is thought to contribute to the pathophysiology of critical illness-related corticosteroid insufficiency.,,,, -373,,,,,Hydrocortisone therapy was started to prevent adrenal insufficiency before laboratory findings for ACTH (adrenocorticotropic hormone) and cortisol levels.,,,, -374,,,,,CONCLUSION: We conclude that intravenous stress doses of hydrocortisone lead to a reduction of systemic inflammation and to a potential improvement in the early outcome of patients undergoing off-pump CABG.,,,, -375,,,,,"CONCLUSION: In intubated trauma patients, the use of an intravenous stress-dose of hydrocortisone, compared with placebo, resulted in a decreased risk of hospital-acquired pneumonia.",,,, -376,,,,,"Early hydrocortisone (HC) treatment may decrease the incidence of bronchopulmonary dysplasia; however, the long-term effects are still under evaluation.",,,, -377,,,,,CONCLUSION: Intravenous hydrocortisone reduced the incidence of AF after cardiac surgery.,,,, -378,,,,,"Assuming a single dose of hydrocortisone improves sensitivity of peripheral tissues to insulin, it may be an interesting candidate for use in reducing insulin resistance in peripheral tissues of horses with several disease states.",,,, -379,,,,,Plasma cortisol and glucagon concentrations were not increased markedly except in a case complicated other systemic bacterial infection.,,,, -380,,,,,"In view of the stimulatory effects of insulin and cortisol on adipogenesis, long-term stimulation of 11betaHSD reductase activity by insulin could aggravate visceral obesity.",,,, -381,,,,,"For this purpose, this review article contends that plasma cortisol is linked to a greater risk of AF.",,,, -382,,,,,"After multivariate analysis, duration of HC stress dose administration was associated with increased risk of mortality (OR 1.11, 95% CI 1.02-1.2, p = 0.021), and total duration of HC treatment was associated with increased risk of sepsis (OR 1.04, 95% CI 1.005-1.075, p = 0.026).",,,, -383,,,,,"Plasma leptin and ghrelin levels in endotoxin-treated dogs were correlated with serum nitric oxide (r = .955 and r = .890; p < .001), procalcitonin (r = .825 and r = .716; p < .001), cortisol (r = .823 and r = .786; p < .001), and hepatorenal injury markers (r = .580 to .745 and r = .393 to .574; p < .05 to .01).",,,, -384,,,,,Contribution of cortisol deficiency to septic shock.,,,, -385,,,,,The objective of this study was to demonstrate the effect of stress doses of hydrocortisone during the initial phase of human septic shock on the serum values of the neurospecific protein S-100B in comparison to the inflammation markers interleukin (IL)-8 in serum and polymorphonuclear (PMN) elastase in plasma.,,,, -386,,,,,"The synergism between insulin and cortisol in stimulating energy deposition, associated with a decreased effect of corticotropin-releasing factor in stimulating energy expenditure, is likely to contribute to the development of obesity.",,,, -387,,,,,Higher basal cortisol predicts verbal memory loss in postmenopausal women: Rancho Bernardo Study.,,,, -388,,,,,"A growing body of evidence now suggests that endogenous cortisol, which is produced in significant quantities by the body in a diurnal rhythm, is an important regulator of allergic disease expression and allergic inflammatory responses: lung function varies along with plasma cortisol levels; the number of circulating inflammatory cells varies with plasma cortisol levels; and low levels of endogenous cortisol may be associated with risk for asthma.",,,, -389,,,,,"In conclusion, the data presented here suggest that cortisol can contribute to insulin resistance in ponies with hyperlipoproteinaemia.",,,, -390,,,,,"OBJECTIVE: To investigate the relationship of cortisol concentrations during the first week of life to patent ductus arteriosus (PDA), markers of lung inflammation, and respiratory outcome in very low birth weight infants.",,,, -391,,,,,Oral pH-modified release budesonide versus 6-methylprednisolone in active Crohn's disease.,,,, -392,,,,,Pharmacokinetics of high dose methylprednisolone and use in hematological malignancies.,,,, -393,,,,,"Methylprednisolone in advanced chronic lymphocytic leukaemia: rationale for, and effectiveness of treatment suggested by DiSC assay.",,,, -394,,,,,The effects of intravenous pulse methylprednisolone on immunological and inflammatory processes in ankylosing spondylitis.,,,, -395,,,,,The effect of methylprednisolone (MP) on the cell kinetic response to cyclophosphamide (CP) and Adriamycin (ADR) in C3H/HeJ spontaneous mammary tumors and hematopoietic tissue was investigated.,,,, -396,,,,,High-dose intravenous methyl-prednisolone in chronic polymyositis/dermatomyositis.,,,, -397,,,,,Comparing Intratympanic Gentamicin with Methylprednisolone in Meniere's Disease with Non-Serviceable Hearing.,,,, -398,,,,,"High-dose methylprednisolone, vincristine, MTX, and ara-C (SOMA) as initial bulk reducing therapy in non-Hodgkin's lymphoma of unfavorable histology: preliminary results of an ongoing phase II study.",,,, -399,,,,,A Prospective Study Comparing the Efficacy of Local Injection of Platelet-Rich Plasma (PRP) vs Methylprednisolone in Plantar Fasciitis.,,,, -400,,,,,A controlled trial of 6-methylprednisolone in acute alcoholic hepatitis.,,,, -401,,,,,[Short-term therapy with methylprednisolone in exacerbated obstructive respiratory tract diseases].,,,, -402,,,,,Methylprednisolone and 60 Days in Hospital Survival in Coronavirus Disease 2019 Pneumonia.,,,, -403,,,,,Intra-Carpal Injection of Ozone versus Methylprednisolone in Carpal Tunnel Syndrome of Systemic Sclerosis Patients: A Randomized Single-Blind Clinical Trial.,,,, -404,,,,,Methylprednisolone Pulses in West Syndrome: A New Weapon in the Armory-Is it Needed?,,,, -405,,,,,Patient underwent treatment with milrinone and methylprednisolone that showed reduction in myocardial inflammation and significantly improved myocardial contractility.,,,, -406,,,,,"Neurologically, the therapeutic dosages of anticoagulants are linked to the high incidence of thrombotic complexities, while methylprednisolone is associated with myopathy.",,,, -407,,,,,"Conclusion: Based on the current data, the efficacy and safety of local injection of triamcinolone and methylprednisolone at doses of 20 and 40 mg were associated with a significant improvement in pain, functional status, and strength.",,,, -408,,,,,OBJECTIVE: To validate the responsiveness of cerebrospinal fluid (CSF) inflammatory biomarkers to treatment with natalizumab and methylprednisolone in progressive MS and to examine the relationship between CSF inflammatory and tissue damage biomarkers.,,,, -409,,,,,The region was identified as a significant predictor of use of intravenous methylprednisolone in MCD and MN patients.,,,, -410,,,,,"Clinical commentary on ""Two cases of anaphylactic shock by methylprednisolone in neuromyelitis optica"".",,,, -411,,,,,CONCLUSION: Results show that inhalation of budesonide (2 mg 3 times/day) and systemic methylprednisolone (40 mg/day) had similar clinical outcome in AECOPD.,,,, -412,,,,,A Clinical Trial Comparing the Safety and Efficacy of Topical Tacrolimus versus Methylprednisolone in Ocular Graft-versus-Host Disease.,,,, -413,,,,,The purpose of this study was to evaluate the efficacy of supraperiosteal injection of methylprednisolone compared with an oral tablet form and intravenous (i.v.) injection in the prevention of postoperative pain and oedema associated with inflammation.,,,, -414,,,,,Gamma globulin and methylprednisolone in idiopathic thrombocytopenic purpura.,,,, -415,,,,,Methylprednisolone and hepatotoxicity in Graves' ophthalmopathy.,,,, -416,,,,,"In orthognathic surgery, methylprednisolone > or =85 mg administered intravenously seemed sufficient to produce a significant decrease in edema, and several trials pointed toward a neuroregeneration effect, but no statistical analysis could be performed.",,,, -417,,,,,Response of symptoms and synovitis to intra-muscular methylprednisolone in osteoarthritis of the hand: an ultrasonographic study.,,,, -418,,,,,Long-term results of high-dose methylprednisolone in aplastic anemia.,,,, -419,,,,,"Efficacy of methylprednisolone, cyclophosphamide in pediatric IgA nephropathy assessed by renal biopsy.",,,, -420,,,,,"The impaired effect on lymphocyte blastogenesis of glucocorticoids administered in vivo, in contrast to a normal in vitro reaction to dexamethasone, together with recent findings of an altered glucocorticoid receptor pharmacology in AD, points to a decreased biological in vivo efficiency of methylprednisolone in atopic dermatitis.",,,, -421,,,,,"CONCLUSION: In this single-center trial, combined vasopressin-epinephrine and methylprednisolone during resuscitation and stress-dose hydrocortisone in postresuscitation shock improved survival in refractory in-hospital cardiac arrest.",,,, -422,,,,,Weekly bortezomib/methylprednisolone is effective and well tolerated in relapsed multiple myeloma.,,,, -423,,,,,Amsacrine combined with etoposide and high-dose methylprednisolone as salvage therapy in acute lymphoblastic leukemia in children.,,,, -424,,,,,Controlled clinical trial of IV cyclophosphamide versus IV methylprednisolone in severe neurological manifestations in systemic lupus erythematosus.,,,, -425,,,,,Delayed hypersensitivity to 6-methyl-prednisolone in Henoch Schoenlein syndrome.,,,, -426,,,,,Rectal absorption of radioactive 6-alpha-methyl prednisolone in ulcerative colitis.,,,, -427,,,,,Controlled trial of pulse methylprednisolone versus two regimens of pulse cyclophosphamide in severe lupus nephritis.,,,, -428,,,,,"The National Heart, Lung, and Blood Institute's ARDS Network currently is testing the use of methylprednisolone in late ARDS.",,,, -429,,,,,"(3) Preliminary results of an interim analysis from an ongoing randomized, prospective study showed that methylprednisolone (plus an antiviral agent?) may be useful for improving peripheral vestibular function in vestibular neuritis.",,,, -430,,,,,This is the first report of cyclophosphamide and methylprednisolone leading to complete and sustained resolution of GAVE in association with systemic sclerosis.,,,, -431,,,,,We compared lymphocyte-suppressive potencies of prednisolone and methylprednisolone in rheumatoid arthritis (RA).,,,, -432,,,,,"Despite the lucrative ""off label"" markets for methylprednisolone in SCI, no Food and Drug Association indication has been obtained.",,,, -433,,,,,Extraocular muscle responses to high dose intravenous methylprednisolone in myasthenia gravis.,,,, -434,,,,,The increased CSF levels of TNF-sRp55 in response to MP circumstantially suggest that this receptor could partially account for the beneficial effects of MP in acute MS.,,,, -435,,,,,"Such an effect has been demonstrated between clarithromycin and methylprednisolone, two drugs that may be administered concomitantly in asthma.",,,, -436,,,,,"In this study, low-dose methylprednisolone (0.8 mg/kg/day, MP) was used to induce a steroid-resistant lupus nephritis (SR-LN) mouse model in weeks one to four, and a therapeutic steroid dosage (MP 12 mg/kg/day) or a combined PNS (PNS 100 mg/kg/day) treatment was administered from week five to eight.",,,, -437,,,,,MP was administrated in three alternative ways: intraperitoneally during the induction of cytotoxic edema or immediately after finishing cytotoxic edema induction in a dose of 100 mg/kg b.w.; into the internal carotid artery within 2 h after finishing cytotoxic edema induction in a dose of 50 mg/kg b.w.; into internal carotid artery 10 min after edema induction by BBBd in a dose of 50 mg/kg b.w.,,,, -438,,,,,"On the other hand, daily administration of methylprednisolone and tenoxicam for 4 weeks caused increased inflammation and fibrosis and wasn't affective on protection of nerve physiomorphology.",,,, -439,,,,,Methylprednisolone was temporarily stopped while a broad work up for inflammatory and neoplastic causes was pursued.,,,, -440,,,,,"Pneumocystis pneumonia induced by this dose of tacrolimus has been reported in many cases; however, we encountered a rare case of Pneumocystis pneumonia induced by low-dose tacrolimus and methylprednisolone.",,,, -441,,,,,The increased interval in the administration of MP resulted in slightly greater pain and an increased prevalence of NeP.,,,, -442,,,,,"We describe that high-dose methylprednisolone (20 mg/kg) can induce multifocal osteonecrosis (ON) in conjunction with thrombocytopenia, hypofibrinogenemia, and hyperlipemia.",,,, -443,,,,,"OBJECTIVE: To report the third published case, as of April 8, 2006, of methylprednisolone-induced toxic hepatitis.",,,, -444,,,,,"To our knowledge, this is the first discussion considering the possibility that the methylprednisolone recommended by NASCIS may cause acute corticosteroid myopathy.",,,, -445,,,,,"However, high-dose steroids like dexamethasone or methylprednisolone had proven their clearcut anti-tumoral action.",,,, -446,,,,,"Methylprednisolone increases some astrogliosis and inflammation biomarkers' levels; however, it did not affect the apoptotic biomarkers.",,,, -447,,,,,Effect of Methylprednisolone on Inflammation and Coagulation in Patients with Severe COVID-19: A Retrospective Cohort Study.,,,, -448,,,,,"METHODS/DESIGN: This study is a 12-week, randomised, double-blind, placebo-controlled trial analysing the effects of high-dose intravenous methylprednisolone in very early SSc.",,,, -449,,,,,"Methods: The potential interferences Se@SiO2 nanocomposites may have to the therapeutic effect of methylprednisolone (MPS) were evaluated by classical therapeutic effect index of acute respiratory distress syndrome (ARDS), such as wet-to-dry weight ratio, inflammatory factors IL-1beta and TNF-alpha.",,,, -450,,,,,Our case likely represents worsening of DON due to soft tissue swelling secondary to OR despite cover with IVMP in a patient previously responsive to IVMP alone.,,,, -451,,,,,[Treatment of invasive thymoma with myasthenia gravis: a case report responsive to azathioprine and methylprednisolone].,,,, -452,,,,,High-dose intravenous methylprednisolone is the first-line therapy for acute exacerbations of NMO.,,,, -453,,,,,"CONCLUSION: Although the delayed administration of high-dose MP did not significantly increase the severity of pain or prevalence of NeP, it should still be avoided due to the increased risk of serious side effects.",,,, -454,,,,,Methylprednisolone has been used in other Th1 mediated diseases such as rheumatoid arthritis in an attempt to switch off the immune response and so we investigated the efficacy of three days of high dose (1 g) intravenous methylprednisolone at the start of prednisolone therapy in leprosy Type 1 reactions and nerve function impairment.,,,, -455,,,,,Myelitis in these patients was not related to graft versus host disease or immune reconstitution and was responsive to intravenous methylprednisolone and cyclophosphamide.,,,, -456,,,,,"We investigated the effects of YM264, WEB2086, methylprednisolone and ticlopidine on puromycin-induced nephropathy in the rat.",,,, -457,,,,,"The study strongly suggests that methylprednisolone has significant beneficial effects in human spinal cord injury, that these effects occur only when the drug is given within 8 hr, and that it helps even in patients with severe spinal cord injuries.",,,, -458,,,,,"Comparison of the effects of 2 doses of methylprednisolone on pain, swelling, and trismus after third molar surgery.",,,, -459,,,,,Steatohepatitis during methylprednisolone therapy for ulcerative colitis exacerbation.,,,, -460,,,,,These results suggest that increasing the uric acid concentration may represent one of the possible mechanisms of action of methylprednisolone in multiple sclerosis.,,,, -461,,,,,"OBJECTIVE: Compare the therapeutic efficacy of an oral/metered-dose inhaler (oral/MDI) regimen to an intravenous/nebulizer (I.V./neb) regimen of methylprednisolone, cefuroxime, and inhaled albuterol and ipratropium bromide in patients hospitalized for exacerbations of chronic obstructive pulmonary disease (COPD).",,,, -462,,,,,"Similar to the CRPS clinical response to glucocorticoids, we now demonstrate that chronic hindpaw edema in the sciatic transection CRPS model is reversed by a continuous infusion of MP (3 mg/kg/day over 21 days), and this anti-edematous effect persists for at least 1 week after discontinuing MP.",,,, -463,,,,,STUDY OBJECTIVES: To assess whether IV methylprednisolone exerts a specific early effect on dyspnea in patients with an exacerbation of asthma.,,,, -464,,,,,REVIEWER'S CONCLUSIONS: Cyclophosphamide regimen treatment is a form of care in neuropsychiatric involvement in systemic lupus erythematosus with no evidence to prove better effectiveness and safety when compared with methylprednisolone.,,,, -465,,,,,"RESULTS: Both methylprednisolone and dexamethasone significantly reduced swelling and trismus (P < .05, Kruskal-Wallis test), whereas the methylprednisolone group had significantly less pain (P < .05, Kruskal-Wallis test) and consumed a lower amount of analgesics (P < .05, chi2 test) during the early postoperative days.",,,, -466,,,,,Methylprednisolone only inhibited granulocytopenia and thrombocytopenia when zymosan-activated serum or fibrinogen-depleted plasma were infused.,,,, -467,,,,,"In addition, we detected that sufentanil provided prolonged pain relief up to 24 h when compared with control, whereas when we combined sufentanil plus methylprednisolone, we found that it further reduced pain and use of analgesics when compared with sufentanil.",,,, -468,,,,,These findings demonstrate that MP may suppress post-traumatic inflammatory reaction by inhibiting both the AP-1 and NF-kappaB transcription cascades via a GR mechanism.,,,, -469,,,,,"This study assessed the effectiveness of a ganciclovir, methylprednisolone, and immunoglobulin combination (TAGMIC) therapy in decreasing cognitive impairment and mortality among patients with Japanese encephalitis.",,,, -470,,,,,"From indirect comparisons, most interventions showed decreased risk of developing RA compared to placebo at 12 months, reaching statistical significance for methotrexate (OR 0.16 [95% CI 0.08, 0.33]) and intramuscular methylprednisolone (OR 0.72 [95% CI 0.53, 0.99]).",,,, -471,,,,,Treatment with a pulse of methylprednisolone reduced both abdominal pain and lesion size.,,,, -472,,,,,Methylprednisolone prevents propranolol-induced airway hyperreactivity in the Basenji-greyhound dog.,,,, -473,,,,,Administration of methylprednisolone to prevent severe ovarian hyperstimulation syndrome in patients undergoing in vitro fertilization.,,,, -474,,,,,"Combined methylprednisolone, bupivacaine and morphine reduced pain, joint swelling, time of immobilization, duration of sick leave and return to sports after the arthroscopic procedure.",,,, -475,,,,,Forty-eight patients who underwent bone marrow transplantation (BMT) from serologically HLA-matched unrelated donors received tacrolimus (FK506) alone or with methotrexate (MTX) and/or methylprednisolone (mPSL) to prevent graft-versus-host disease (GVHD).,,,, -476,,,,,"Thus, calpeptin and methylprednisolone are found to be neuroprotective in SCI.",,,, -477,,,,,"Methylprednisolone prevents the development of autotomy and neuropathic edema in rats, but has no effect on nociceptive thresholds.",,,, -478,,,,,Chronically impaired renal function and the use of methylprednisolone may be the risk factors for SP.,,,, -479,,,,,"Because a common therapy for acute spinal cord injury is the use of an antiinflammatory synthetic glucocorticoid (methylprednisolone), we sought to determine mechanisms contributing to inflammation shortly after acute injury.",,,, -480,,,,,"Combined treatments of rG-CSF with cefotaxime, cefazolin, fosfomycin, gentamicin or amphotericin B were evaluated in systemic infections with Pseudomonas aeruginosa, Escherichia coli, Serratia marcescens, Staphylococcus aureus and Candida albicans in leucopenic mice induced by pretreatment with cyclophosphamide.",,,, -481,,,,,"One such marker, CTX-M-15, expressed by Enterobacteriaceae produces beta-lactamases, which hydrolyze the cephalosporin group of antibiotics, such as cefotaxime, used in the treatment of both Gram-positive and negative bacterial infections.",,,, -482,,,,,"CONS, Staphylococcus aureus, Enterococci, Escherichia coli, Klebsiella and Enterobacter represented 91.9% of LOS episodes and were susceptible to vancomycin and cefotaxime (96.1%), vancomycin and gentamicin (97.0%) and cloxacillin and gentamicin (38.1%).",,,, -483,,,,,"The protective effect of cefotaxime, aztreonam and gentamicin in peritonitis induced by E. coli alone or combined with B. fragilis was evaluated by analysing mortality at 24 and 48 h after bacterial inoculation and treating the animals with two doses of each antibiotic.",,,, -484,,,,,"HR 810 had more potent protective effect than ceftazidime (CAZ), cefoperazone (CPZ), and cefotaxime (CTX) on systemic infections induced by Escherichia coli Ec-31, Staphylococcus aureus SMITH, and Serratia marcescens Sm-6 in mice.",,,, -485,,,,,"1,480 patients, undergoing elective orthopedic and traumatic surgery, received intragluteal injections of ceftriaxone (Rocephin) to prevent bacterial infections.",,,, -486,,,,,Proceedings: A double blind trial of carbenoxolone and geranyl farnesylacetate in gastric ulcer.,,,, -487,,,,,A controlled double-blind study was performed in 17 institutes using gefarnate as a control drug in order to investigate the therapeutic effect and safety of pirenzepine dihydrochloride (LS 519) in duodenal ulcer.,,,, -488,,,,,Gefarnate at 300 mg/kg (p.o.) significantly inhibited phenylbutazone-induced gastric ulcers in rats but had no effect on other ulcer models.,,,, -489,,,,,We tested streptomycin (ST) and neomycin (NEO) as analgesic agents applied in situ in rat paw inflammation caused by formalin or carrageenan administration.,,,, -490,,,,,[ON THE ACTION OF A NEOMYCIN AND THIOPENICOL PREPARATION IN EXPERIMENTAL BURNS].,,,, -491,,,,,"Therefore, we investigated the effect of long-term exposure of an antibiotic cocktail composed of Vancomycin, Neomycin, and Streptomycin, on tumor development and progression in the ApcMin/+ mouse, an established genetic model for familial adenomatous polyposis.",,,, -492,,,,,Ultrahigh doses of gentamicin and clinically relevant doses of neomycin affect inflammation and angiogenesis in in vivo and in vitro models.,,,, -493,,,,,"Biodegradable polyaspartamide (PASPAM) was grafted with several functional groups to implement diverse roles-octadecylamine (C 18 ) for nano-aggregate formation, dopamine (DOPA) for adhesive function, neomycin (NEO) for inhibition of bacterial infection.",,,, -494,,,,,Kaposi's sarcoma-associated herpesvirus-positive primary effusion lymphoma tumor formation in NOD/SCID mice is inhibited by neomycin and neamine blocking angiogenin's nuclear translocation.,,,, -495,,,,,Neomycin and the combination of neomycin and bacitracin in the prevention of bacterial infection in surgery of the colon and/or rectum.,,,, -496,,,,,Results of salvage therapy with mini-hyper-CVD and inotuzumab ozogamicin with or without blinatumomab in pre-B acute lymphoblastic leukemia.,,,, -497,,,,,"The impressive clinical success of the continuously intravenously infused T cell-redirecting bispecific antibody (T-bsAb) blinatumomab (anti-CD19 x anti-CD3), and of engineered T cells expressing anti-CD19 chimeric antigen receptors (CAR-T cells) in hematological malignancies, has led to renewed interest in a novel cancer immunotherapy strategy that combines features of antibody- and cell-based therapies.",,,, -498,,,,,Blinatumomab and inotuzumab ozogamycin represent promising alternatives to conventional chemotherapy in acute lymphoblastic leukaemia (ALL).,,,, -499,,,,,Efficacy of ciprofloxacin and dexamethasone in experimental pseudomonas endophthalmitis.,,,, -500,,,,,CONCLUSIONS: Combination therapy of adalimumab and ciprofloxacin is more effective than adalimumab monotherapy to achieve fistula closure in CD.,,,, -501,,,,,"Tested substances displayed inhibitory effect towards E. coli DNA gyrase, though less than ciprofloxacin.",,,, +320,,,,,"CONCLUSIONS: Early PN did not affect plasma concentrations of ACTH and (free) cortisol, but increased the incidence of septic shock, which statistically explained why more patients on early PN received corticosteroids.",,,, +321,,,,,"Sixteen reacted to tixocortol pivalate and also to other corticosteroids, particularly to hydrocortisone, which could explain exacerbations of eczema in these cases.",,,, +322,,,,,"Finally, transient pre-treatment of healthy humans with cortisol induces a bi-phasic response during a later, delayed systemic inflammatory response: an intermediate cortisol concentration augments inflammation while a high cortisol concentration is neither pro- nor anti-inflammatory.",,,, +323,,,,,"Adrenaline induces the early posthypoglycaemic insulin resistance, whereas cortisol and growth hormone are important for the insulin resistance that is observed later following hypoglycaemia.",,,, +324,,,,,"RESULTS: Within 24 hours following TBI, the concentrations of total cortisol, ACTH and gastrin increased proportionally to the severity of injury, especially significant in the experimental group (P less than 0.05).",,,, +325,,,,,NEW OR UNIQUE INFORMATION PROVIDED: This case is the first published report of hydrocortisone-responsive hypotension and transient CIRCI associated with naturally occurring septic shock in a dog.,,,, +326,,,,,Several types of the congenital adrenal hyperplasias are associated with decreased cortisol production and excessive adrenal sex steroid secretion.,,,, +327,,,,,[Use of cryo-apheresis in the treatment of patients with cortisol-dependent bronchial asthma].,,,, +328,,,,,Hypotension after recruitment was reduced by HC (0 vs. 30%).,,,, +329,,,,,Fetal plasma cortisol concentrations were increased ( P < 0.05) during all levels of hypoxia.,,,, +330,,,,,"INTRA-CELL CORTISOL: Attention is also focused on the potential implication of cortisol in the genesis of metabolic syndrome, because cortisol is a potent antagonist of the effect of insulin and its presence in excess enhances visceral obesity and insulin resistance.",,,, +331,,,,,The effect of hydrocortisone on standardized skin-surface trauma.,,,, +332,,,,,The action of hydrocortisone in synovial inflammation.,,,, +333,,,,,"The effects of stressful life events, coping, and cortisol on HIV infection.",,,, +334,,,,,"Immunologic and hemodynamic effects of ""low-dose"" hydrocortisone in septic shock: a double-blind, randomized, placebo-controlled, crossover study.",,,, +335,,,,,"To prolong the anti-tumor effect some mice were also given cyclophosphamide, hydrocortisone, or a second injection of virus.",,,, +336,,,,,"In conclusion, HRT in postmenopausal asthmatic women has a favorable influence on the course of asthma, reduces daily use of glucocorticosteroids and frequency of asthma exacerbations and normalizes serum concentrations of estradiol, cortisol and DHEAS, which were decreased before HRT.",,,, +337,,,,,"However, after adjusting for the effect of obesity by multiple regression, higher plasma cortisol was independently associated with higher diastolic blood pressure in men (r = 0.21, P = 0.04) but not in women, and higher fasting serum triglyceride levels in women (r = 0.28, P < 0. 001) but not in men.",,,, +338,,,,,"ii) Reduction of cortisone to cortisol in the liver may increase insulin resistance in type 2 diabetes mellitus, and inhibition of the enzyme may lead to a decrease in gluconeogenesis.",,,, +339,,,,,"Pretreatment of rats with hydrocortisone or protamin-Zn-insulin within 4 days altered in subsequent acute hypoxia (3 hrs, ""height"" 10 000 m) the isoenzyme spectrum of LDH in lungs, liver tissue and kidney cortex.",,,, +340,,,,,Previously we related persistent cortisol increases to memory impairments in elderly humans studied over five years.,,,, +341,,,,,It was suggested that the progressive shift from type 1 to type 2 cytokine production characteristic of HIV infection could be at least partially provoked by the increase in the production of cortisol and the reduction of DHEA.,,,, +342,,,,,CONCLUSIONS: This study suggests that 24 h urinary free cortisol could be considered as a potential index of adrenal cortisol production in patients with liver cirrhosis and it potentially detects patients with a high mortality risk.,,,, +343,,,,,Congenital adrenal hyperplasia (CAH) is an autosomal recessive disorder that leads to the partial or complete deficiency of cortisol and aldosterone production from the adrenal glands.,,,, +344,,,,,[Reaction of autogenous cortisol production in patients with extensive psoriasis vulgaris or atopic dermatitis following external administration of a 0.25% prednicarbate salve (W/O emulsion)].,,,, +345,,,,,"OBJECTIVE: Corticosteroid-binding globulin (CBG), the cortisol transport protein, is cleaved from high-affinity (haCBG) to low-affinity (laCBG) CBG at sites of inflammation releasing bioavailable, anti-inflammatory cortisol.",,,, +346,,,,,The propensity to develop type 1 diabetes or type 2 diabetes/metabolic syndrome depends on the propensity to release of cortisol which correlates with race.,,,, +347,,,,,"CIRCI is characterized by an inadequate production of cortisol in relation to an increased demand during periods of severe stress, particularly in critical illnesses such as sepsis or septic shock.",,,, +348,,,,,Synacthen test diagnosed Addison's disease with a clear deficiency of cortisol production.,,,, +349,,,,,"Enhanced cortisol production rates, free cortisol, and 11beta-HSD-1 expression correlate with visceral fat and insulin resistance in men: effect of weight loss.",,,, +350,,,,,"Obesity is also related to dysregulation of cortisol production by the pre-receptor enzyme, 11beta-hydroxysteroid dehydrogenase, and we speculate that this may have a role in the pathogenesis of obesity and raised ICP seen in IIH.",,,, +351,,,,,"This is an extremely rare case of bilateral adrenal tumors, in which the left adrenocortical tumor produced and secreted cortisol or both cortisol and aldosterone and the right one produced and secreted both aldosterone and cortisol, as confirmed by clinical findings and pathological studies using immunohistochemical analysis.",,,, +352,,,,,"We conclude that the clinical picture of late-onset adrenal insufficiency in preterm infants is not a result of an absolute deficiency of cortisol production, but may be a result of a limited ability to synthesize sufficient cortisol for the degree of clinical stress.",,,, +353,,,,,"Ironically, despite our understanding of the various stressors that promote chronic adult-onset asthma, most of which are known to elevate cortisol production via the hypothalamic-pituitary-adrenal (HPA) axis, inhaled and systemic corticosteroids are the mainstay for the treatment of chronic asthma.",,,, +354,,,,,Glucocorticoid insufficiency is common during sepsis and may result from insufficient production of cortisol or peripheral tissues resistance.,,,, +355,,,,,"This likely represents an adaptive response to LTH, to prevent excessive cortisol production that would restrict fetal growth and potentially induce preterm delivery.",,,, +356,,,,,"The reduction in local cortisol production which diminishes the endogenous anti-inflammatory effects, also allows for the progression of both vascular and pulmonary inflammation.",,,, +357,,,,,"CONCLUSIONS: Patients with newly diagnosed, untreated PC yielded significantly higher cortisol and lower estradiol serum concentrations than controls.",,,, +358,,,,,"The tumour secreted excessive cortisol and dehydroepiandrosterone-sulphate (DHEA-S), and had invaded the right hepatic lobe and vena cava.",,,, +359,,,,,Replacement doses of hydrocortisone were administered throughout treatment to counteract potential adrenal insufficiency secondary to the ketoconazole.,,,, +360,,,,,Amplication by hydrocortisone of the induction of cytotoxic response in vitro to syngeneic murine leukemias.,,,, +361,,,,,The results demonstrated that the intrarectal dose of indomethacin and hydrocortisone inhibited the development of tumors from microscopic carcinoma lesions in the large bowel and growing further.,,,, +362,,,,,"Growth of ovarian, lung, breast, and kidney carcinomas was increased by 136%, 126%, 78% and 69%, respectively, whereas melanomas, sarcomas, and colon tumors were inhibited by hydrocortisone.",,,, +363,,,,,Insufficient cortisol limits the ability of the sick newborn to handle stress and inhibit pulmonary inflammation.,,,, +364,,,,,"BACKGROUND: Hepatic 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) activity, which converts cortisone (inactive) to cortisol, is downregulated in obesity.",,,, +365,,,,,"High-dose hydrocortisone treatment given in the first few hours after a traumatic experience was associated with significant favorable changes in the trajectory of exposure to trauma, as expressed by the reduced risk of the development of PTSD post-trauma.",,,, +366,,,,,"Under normal conditions, stress induces increased cortisol secretion that counteracts inflammatory reactions.",,,, +367,,,,,Hydrocortisone (HC) reduced the macrophage content of four murine tumors to less than half of control values.,,,, +368,,,,,"Further, because infant formula contains only trace amounts of glucocorticoids, these findings suggest that cortisol in milk is a novel biological pathway through which breastfeeding may protect against later obesity.",,,, +369,,,,,"Conclusions and Relevance: Among adults with severe sepsis not in septic shock, use of hydrocortisone compared with placebo did not reduce the risk of septic shock within 14 days.",,,, +370,,,,,These findings suggest that HC may protect against hyperoxic injury in the developing pulmonary vasculature.,,,, +371,,,,,OBJECTIVE: Cortisol clearance is reduced in sepsis and may contribute to the development of impaired adrenocortical function that is thought to contribute to the pathophysiology of critical illness-related corticosteroid insufficiency.,,,, +372,,,,,Hydrocortisone therapy was started to prevent adrenal insufficiency before laboratory findings for ACTH (adrenocorticotropic hormone) and cortisol levels.,,,, +373,,,,,CONCLUSION: We conclude that intravenous stress doses of hydrocortisone lead to a reduction of systemic inflammation and to a potential improvement in the early outcome of patients undergoing off-pump CABG.,,,, +374,,,,,"CONCLUSION: In intubated trauma patients, the use of an intravenous stress-dose of hydrocortisone, compared with placebo, resulted in a decreased risk of hospital-acquired pneumonia.",,,, +375,,,,,"Early hydrocortisone (HC) treatment may decrease the incidence of bronchopulmonary dysplasia; however, the long-term effects are still under evaluation.",,,, +376,,,,,CONCLUSION: Intravenous hydrocortisone reduced the incidence of AF after cardiac surgery.,,,, +377,,,,,"Assuming a single dose of hydrocortisone improves sensitivity of peripheral tissues to insulin, it may be an interesting candidate for use in reducing insulin resistance in peripheral tissues of horses with several disease states.",,,, +378,,,,,Plasma cortisol and glucagon concentrations were not increased markedly except in a case complicated other systemic bacterial infection.,,,, +379,,,,,"In view of the stimulatory effects of insulin and cortisol on adipogenesis, long-term stimulation of 11betaHSD reductase activity by insulin could aggravate visceral obesity.",,,, +380,,,,,"For this purpose, this review article contends that plasma cortisol is linked to a greater risk of AF.",,,, +381,,,,,"After multivariate analysis, duration of HC stress dose administration was associated with increased risk of mortality (OR 1.11, 95% CI 1.02-1.2, p = 0.021), and total duration of HC treatment was associated with increased risk of sepsis (OR 1.04, 95% CI 1.005-1.075, p = 0.026).",,,, +382,,,,,"Plasma leptin and ghrelin levels in endotoxin-treated dogs were correlated with serum nitric oxide (r = .955 and r = .890; p < .001), procalcitonin (r = .825 and r = .716; p < .001), cortisol (r = .823 and r = .786; p < .001), and hepatorenal injury markers (r = .580 to .745 and r = .393 to .574; p < .05 to .01).",,,, +383,,,,,Contribution of cortisol deficiency to septic shock.,,,, +384,,,,,The objective of this study was to demonstrate the effect of stress doses of hydrocortisone during the initial phase of human septic shock on the serum values of the neurospecific protein S-100B in comparison to the inflammation markers interleukin (IL)-8 in serum and polymorphonuclear (PMN) elastase in plasma.,,,, +385,,,,,"The synergism between insulin and cortisol in stimulating energy deposition, associated with a decreased effect of corticotropin-releasing factor in stimulating energy expenditure, is likely to contribute to the development of obesity.",,,, +386,,,,,Higher basal cortisol predicts verbal memory loss in postmenopausal women: Rancho Bernardo Study.,,,, +387,,,,,"A growing body of evidence now suggests that endogenous cortisol, which is produced in significant quantities by the body in a diurnal rhythm, is an important regulator of allergic disease expression and allergic inflammatory responses: lung function varies along with plasma cortisol levels; the number of circulating inflammatory cells varies with plasma cortisol levels; and low levels of endogenous cortisol may be associated with risk for asthma.",,,, +388,,,,,"In conclusion, the data presented here suggest that cortisol can contribute to insulin resistance in ponies with hyperlipoproteinaemia.",,,, +389,,,,,"OBJECTIVE: To investigate the relationship of cortisol concentrations during the first week of life to patent ductus arteriosus (PDA), markers of lung inflammation, and respiratory outcome in very low birth weight infants.",,,, +390,,,,,Oral pH-modified release budesonide versus 6-methylprednisolone in active Crohn's disease.,,,, +391,,,,,Pharmacokinetics of high dose methylprednisolone and use in hematological malignancies.,,,, +392,,,,,"Methylprednisolone in advanced chronic lymphocytic leukaemia: rationale for, and effectiveness of treatment suggested by DiSC assay.",,,, +393,,,,,The effects of intravenous pulse methylprednisolone on immunological and inflammatory processes in ankylosing spondylitis.,,,, +394,,,,,The effect of methylprednisolone (MP) on the cell kinetic response to cyclophosphamide (CP) and Adriamycin (ADR) in C3H/HeJ spontaneous mammary tumors and hematopoietic tissue was investigated.,,,, +395,,,,,High-dose intravenous methyl-prednisolone in chronic polymyositis/dermatomyositis.,,,, +396,,,,,Comparing Intratympanic Gentamicin with Methylprednisolone in Meniere's Disease with Non-Serviceable Hearing.,,,, +397,,,,,"High-dose methylprednisolone, vincristine, MTX, and ara-C (SOMA) as initial bulk reducing therapy in non-Hodgkin's lymphoma of unfavorable histology: preliminary results of an ongoing phase II study.",,,, +398,,,,,A Prospective Study Comparing the Efficacy of Local Injection of Platelet-Rich Plasma (PRP) vs Methylprednisolone in Plantar Fasciitis.,,,, +399,,,,,A controlled trial of 6-methylprednisolone in acute alcoholic hepatitis.,,,, +400,,,,,[Short-term therapy with methylprednisolone in exacerbated obstructive respiratory tract diseases].,,,, +401,,,,,Methylprednisolone and 60 Days in Hospital Survival in Coronavirus Disease 2019 Pneumonia.,,,, +402,,,,,Intra-Carpal Injection of Ozone versus Methylprednisolone in Carpal Tunnel Syndrome of Systemic Sclerosis Patients: A Randomized Single-Blind Clinical Trial.,,,, +403,,,,,Methylprednisolone Pulses in West Syndrome: A New Weapon in the Armory-Is it Needed?,,,, +404,,,,,Patient underwent treatment with milrinone and methylprednisolone that showed reduction in myocardial inflammation and significantly improved myocardial contractility.,,,, +405,,,,,"Neurologically, the therapeutic dosages of anticoagulants are linked to the high incidence of thrombotic complexities, while methylprednisolone is associated with myopathy.",,,, +406,,,,,"Conclusion: Based on the current data, the efficacy and safety of local injection of triamcinolone and methylprednisolone at doses of 20 and 40 mg were associated with a significant improvement in pain, functional status, and strength.",,,, +407,,,,,OBJECTIVE: To validate the responsiveness of cerebrospinal fluid (CSF) inflammatory biomarkers to treatment with natalizumab and methylprednisolone in progressive MS and to examine the relationship between CSF inflammatory and tissue damage biomarkers.,,,, +408,,,,,The region was identified as a significant predictor of use of intravenous methylprednisolone in MCD and MN patients.,,,, +409,,,,,"Clinical commentary on ""Two cases of anaphylactic shock by methylprednisolone in neuromyelitis optica"".",,,, +410,,,,,CONCLUSION: Results show that inhalation of budesonide (2 mg 3 times/day) and systemic methylprednisolone (40 mg/day) had similar clinical outcome in AECOPD.,,,, +411,,,,,A Clinical Trial Comparing the Safety and Efficacy of Topical Tacrolimus versus Methylprednisolone in Ocular Graft-versus-Host Disease.,,,, +412,,,,,The purpose of this study was to evaluate the efficacy of supraperiosteal injection of methylprednisolone compared with an oral tablet form and intravenous (i.v.) injection in the prevention of postoperative pain and oedema associated with inflammation.,,,, +413,,,,,Gamma globulin and methylprednisolone in idiopathic thrombocytopenic purpura.,,,, +414,,,,,Methylprednisolone and hepatotoxicity in Graves' ophthalmopathy.,,,, +415,,,,,"In orthognathic surgery, methylprednisolone > or =85 mg administered intravenously seemed sufficient to produce a significant decrease in edema, and several trials pointed toward a neuroregeneration effect, but no statistical analysis could be performed.",,,, +416,,,,,Response of symptoms and synovitis to intra-muscular methylprednisolone in osteoarthritis of the hand: an ultrasonographic study.,,,, +417,,,,,Long-term results of high-dose methylprednisolone in aplastic anemia.,,,, +418,,,,,"Efficacy of methylprednisolone, cyclophosphamide in pediatric IgA nephropathy assessed by renal biopsy.",,,, +419,,,,,"The impaired effect on lymphocyte blastogenesis of glucocorticoids administered in vivo, in contrast to a normal in vitro reaction to dexamethasone, together with recent findings of an altered glucocorticoid receptor pharmacology in AD, points to a decreased biological in vivo efficiency of methylprednisolone in atopic dermatitis.",,,, +420,,,,,"CONCLUSION: In this single-center trial, combined vasopressin-epinephrine and methylprednisolone during resuscitation and stress-dose hydrocortisone in postresuscitation shock improved survival in refractory in-hospital cardiac arrest.",,,, +421,,,,,Weekly bortezomib/methylprednisolone is effective and well tolerated in relapsed multiple myeloma.,,,, +422,,,,,Amsacrine combined with etoposide and high-dose methylprednisolone as salvage therapy in acute lymphoblastic leukemia in children.,,,, +423,,,,,Controlled clinical trial of IV cyclophosphamide versus IV methylprednisolone in severe neurological manifestations in systemic lupus erythematosus.,,,, +424,,,,,Delayed hypersensitivity to 6-methyl-prednisolone in Henoch Schoenlein syndrome.,,,, +425,,,,,Rectal absorption of radioactive 6-alpha-methyl prednisolone in ulcerative colitis.,,,, +426,,,,,Controlled trial of pulse methylprednisolone versus two regimens of pulse cyclophosphamide in severe lupus nephritis.,,,, +427,,,,,"The National Heart, Lung, and Blood Institute's ARDS Network currently is testing the use of methylprednisolone in late ARDS.",,,, +428,,,,,"(3) Preliminary results of an interim analysis from an ongoing randomized, prospective study showed that methylprednisolone (plus an antiviral agent?) may be useful for improving peripheral vestibular function in vestibular neuritis.",,,, +429,,,,,This is the first report of cyclophosphamide and methylprednisolone leading to complete and sustained resolution of GAVE in association with systemic sclerosis.,,,, +430,,,,,We compared lymphocyte-suppressive potencies of prednisolone and methylprednisolone in rheumatoid arthritis (RA).,,,, +431,,,,,"Despite the lucrative ""off label"" markets for methylprednisolone in SCI, no Food and Drug Association indication has been obtained.",,,, +432,,,,,Extraocular muscle responses to high dose intravenous methylprednisolone in myasthenia gravis.,,,, +433,,,,,The increased CSF levels of TNF-sRp55 in response to MP circumstantially suggest that this receptor could partially account for the beneficial effects of MP in acute MS.,,,, +434,,,,,"Such an effect has been demonstrated between clarithromycin and methylprednisolone, two drugs that may be administered concomitantly in asthma.",,,, +435,,,,,"In this study, low-dose methylprednisolone (0.8 mg/kg/day, MP) was used to induce a steroid-resistant lupus nephritis (SR-LN) mouse model in weeks one to four, and a therapeutic steroid dosage (MP 12 mg/kg/day) or a combined PNS (PNS 100 mg/kg/day) treatment was administered from week five to eight.",,,, +436,,,,,MP was administrated in three alternative ways: intraperitoneally during the induction of cytotoxic edema or immediately after finishing cytotoxic edema induction in a dose of 100 mg/kg b.w.; into the internal carotid artery within 2 h after finishing cytotoxic edema induction in a dose of 50 mg/kg b.w.; into internal carotid artery 10 min after edema induction by BBBd in a dose of 50 mg/kg b.w.,,,, +437,,,,,"On the other hand, daily administration of methylprednisolone and tenoxicam for 4 weeks caused increased inflammation and fibrosis and wasn't affective on protection of nerve physiomorphology.",,,, +438,,,,,Methylprednisolone was temporarily stopped while a broad work up for inflammatory and neoplastic causes was pursued.,,,, +439,,,,,"Pneumocystis pneumonia induced by this dose of tacrolimus has been reported in many cases; however, we encountered a rare case of Pneumocystis pneumonia induced by low-dose tacrolimus and methylprednisolone.",,,, +440,,,,,The increased interval in the administration of MP resulted in slightly greater pain and an increased prevalence of NeP.,,,, +441,,,,,"We describe that high-dose methylprednisolone (20 mg/kg) can induce multifocal osteonecrosis (ON) in conjunction with thrombocytopenia, hypofibrinogenemia, and hyperlipemia.",,,, +442,,,,,"OBJECTIVE: To report the third published case, as of April 8, 2006, of methylprednisolone-induced toxic hepatitis.",,,, +443,,,,,"To our knowledge, this is the first discussion considering the possibility that the methylprednisolone recommended by NASCIS may cause acute corticosteroid myopathy.",,,, +444,,,,,"However, high-dose steroids like dexamethasone or methylprednisolone had proven their clearcut anti-tumoral action.",,,, +445,,,,,"Methylprednisolone increases some astrogliosis and inflammation biomarkers' levels; however, it did not affect the apoptotic biomarkers.",,,, +446,,,,,Effect of Methylprednisolone on Inflammation and Coagulation in Patients with Severe COVID-19: A Retrospective Cohort Study.,,,, +447,,,,,"METHODS/DESIGN: This study is a 12-week, randomised, double-blind, placebo-controlled trial analysing the effects of high-dose intravenous methylprednisolone in very early SSc.",,,, +448,,,,,"Methods: The potential interferences Se@SiO2 nanocomposites may have to the therapeutic effect of methylprednisolone (MPS) were evaluated by classical therapeutic effect index of acute respiratory distress syndrome (ARDS), such as wet-to-dry weight ratio, inflammatory factors IL-1beta and TNF-alpha.",,,, +449,,,,,Our case likely represents worsening of DON due to soft tissue swelling secondary to OR despite cover with IVMP in a patient previously responsive to IVMP alone.,,,, +450,,,,,[Treatment of invasive thymoma with myasthenia gravis: a case report responsive to azathioprine and methylprednisolone].,,,, +451,,,,,High-dose intravenous methylprednisolone is the first-line therapy for acute exacerbations of NMO.,,,, +452,,,,,"CONCLUSION: Although the delayed administration of high-dose MP did not significantly increase the severity of pain or prevalence of NeP, it should still be avoided due to the increased risk of serious side effects.",,,, +453,,,,,Methylprednisolone has been used in other Th1 mediated diseases such as rheumatoid arthritis in an attempt to switch off the immune response and so we investigated the efficacy of three days of high dose (1 g) intravenous methylprednisolone at the start of prednisolone therapy in leprosy Type 1 reactions and nerve function impairment.,,,, +454,,,,,Myelitis in these patients was not related to graft versus host disease or immune reconstitution and was responsive to intravenous methylprednisolone and cyclophosphamide.,,,, +455,,,,,"We investigated the effects of YM264, WEB2086, methylprednisolone and ticlopidine on puromycin-induced nephropathy in the rat.",,,, +456,,,,,"The study strongly suggests that methylprednisolone has significant beneficial effects in human spinal cord injury, that these effects occur only when the drug is given within 8 hr, and that it helps even in patients with severe spinal cord injuries.",,,, +457,,,,,"Comparison of the effects of 2 doses of methylprednisolone on pain, swelling, and trismus after third molar surgery.",,,, +458,,,,,Steatohepatitis during methylprednisolone therapy for ulcerative colitis exacerbation.,,,, +459,,,,,These results suggest that increasing the uric acid concentration may represent one of the possible mechanisms of action of methylprednisolone in multiple sclerosis.,,,, +460,,,,,"OBJECTIVE: Compare the therapeutic efficacy of an oral/metered-dose inhaler (oral/MDI) regimen to an intravenous/nebulizer (I.V./neb) regimen of methylprednisolone, cefuroxime, and inhaled albuterol and ipratropium bromide in patients hospitalized for exacerbations of chronic obstructive pulmonary disease (COPD).",,,, +461,,,,,"Similar to the CRPS clinical response to glucocorticoids, we now demonstrate that chronic hindpaw edema in the sciatic transection CRPS model is reversed by a continuous infusion of MP (3 mg/kg/day over 21 days), and this anti-edematous effect persists for at least 1 week after discontinuing MP.",,,, +462,,,,,STUDY OBJECTIVES: To assess whether IV methylprednisolone exerts a specific early effect on dyspnea in patients with an exacerbation of asthma.,,,, +463,,,,,REVIEWER'S CONCLUSIONS: Cyclophosphamide regimen treatment is a form of care in neuropsychiatric involvement in systemic lupus erythematosus with no evidence to prove better effectiveness and safety when compared with methylprednisolone.,,,, +464,,,,,"RESULTS: Both methylprednisolone and dexamethasone significantly reduced swelling and trismus (P < .05, Kruskal-Wallis test), whereas the methylprednisolone group had significantly less pain (P < .05, Kruskal-Wallis test) and consumed a lower amount of analgesics (P < .05, chi2 test) during the early postoperative days.",,,, +465,,,,,Methylprednisolone only inhibited granulocytopenia and thrombocytopenia when zymosan-activated serum or fibrinogen-depleted plasma were infused.,,,, +466,,,,,"In addition, we detected that sufentanil provided prolonged pain relief up to 24 h when compared with control, whereas when we combined sufentanil plus methylprednisolone, we found that it further reduced pain and use of analgesics when compared with sufentanil.",,,, +467,,,,,These findings demonstrate that MP may suppress post-traumatic inflammatory reaction by inhibiting both the AP-1 and NF-kappaB transcription cascades via a GR mechanism.,,,, +468,,,,,"This study assessed the effectiveness of a ganciclovir, methylprednisolone, and immunoglobulin combination (TAGMIC) therapy in decreasing cognitive impairment and mortality among patients with Japanese encephalitis.",,,, +469,,,,,"From indirect comparisons, most interventions showed decreased risk of developing RA compared to placebo at 12 months, reaching statistical significance for methotrexate (OR 0.16 [95% CI 0.08, 0.33]) and intramuscular methylprednisolone (OR 0.72 [95% CI 0.53, 0.99]).",,,, +470,,,,,Treatment with a pulse of methylprednisolone reduced both abdominal pain and lesion size.,,,, +471,,,,,Methylprednisolone prevents propranolol-induced airway hyperreactivity in the Basenji-greyhound dog.,,,, +472,,,,,Administration of methylprednisolone to prevent severe ovarian hyperstimulation syndrome in patients undergoing in vitro fertilization.,,,, +473,,,,,"Combined methylprednisolone, bupivacaine and morphine reduced pain, joint swelling, time of immobilization, duration of sick leave and return to sports after the arthroscopic procedure.",,,, +474,,,,,Forty-eight patients who underwent bone marrow transplantation (BMT) from serologically HLA-matched unrelated donors received tacrolimus (FK506) alone or with methotrexate (MTX) and/or methylprednisolone (mPSL) to prevent graft-versus-host disease (GVHD).,,,, +475,,,,,"Thus, calpeptin and methylprednisolone are found to be neuroprotective in SCI.",,,, +476,,,,,"Methylprednisolone prevents the development of autotomy and neuropathic edema in rats, but has no effect on nociceptive thresholds.",,,, +477,,,,,Chronically impaired renal function and the use of methylprednisolone may be the risk factors for SP.,,,, +478,,,,,"Because a common therapy for acute spinal cord injury is the use of an antiinflammatory synthetic glucocorticoid (methylprednisolone), we sought to determine mechanisms contributing to inflammation shortly after acute injury.",,,, +479,,,,,"Combined treatments of rG-CSF with cefotaxime, cefazolin, fosfomycin, gentamicin or amphotericin B were evaluated in systemic infections with Pseudomonas aeruginosa, Escherichia coli, Serratia marcescens, Staphylococcus aureus and Candida albicans in leucopenic mice induced by pretreatment with cyclophosphamide.",,,, +480,,,,,"One such marker, CTX-M-15, expressed by Enterobacteriaceae produces beta-lactamases, which hydrolyze the cephalosporin group of antibiotics, such as cefotaxime, used in the treatment of both Gram-positive and negative bacterial infections.",,,, +481,,,,,"CONS, Staphylococcus aureus, Enterococci, Escherichia coli, Klebsiella and Enterobacter represented 91.9% of LOS episodes and were susceptible to vancomycin and cefotaxime (96.1%), vancomycin and gentamicin (97.0%) and cloxacillin and gentamicin (38.1%).",,,, +482,,,,,"The protective effect of cefotaxime, aztreonam and gentamicin in peritonitis induced by E. coli alone or combined with B. fragilis was evaluated by analysing mortality at 24 and 48 h after bacterial inoculation and treating the animals with two doses of each antibiotic.",,,, +483,,,,,"HR 810 had more potent protective effect than ceftazidime (CAZ), cefoperazone (CPZ), and cefotaxime (CTX) on systemic infections induced by Escherichia coli Ec-31, Staphylococcus aureus SMITH, and Serratia marcescens Sm-6 in mice.",,,, +484,,,,,"1,480 patients, undergoing elective orthopedic and traumatic surgery, received intragluteal injections of ceftriaxone (Rocephin) to prevent bacterial infections.",,,, +485,,,,,Proceedings: A double blind trial of carbenoxolone and geranyl farnesylacetate in gastric ulcer.,,,, +486,,,,,A controlled double-blind study was performed in 17 institutes using gefarnate as a control drug in order to investigate the therapeutic effect and safety of pirenzepine dihydrochloride (LS 519) in duodenal ulcer.,,,, +487,,,,,Gefarnate at 300 mg/kg (p.o.) significantly inhibited phenylbutazone-induced gastric ulcers in rats but had no effect on other ulcer models.,,,, +488,,,,,We tested streptomycin (ST) and neomycin (NEO) as analgesic agents applied in situ in rat paw inflammation caused by formalin or carrageenan administration.,,,, +489,,,,,[ON THE ACTION OF A NEOMYCIN AND THIOPENICOL PREPARATION IN EXPERIMENTAL BURNS].,,,, +490,,,,,"Therefore, we investigated the effect of long-term exposure of an antibiotic cocktail composed of Vancomycin, Neomycin, and Streptomycin, on tumor development and progression in the ApcMin/+ mouse, an established genetic model for familial adenomatous polyposis.",,,, +491,,,,,Ultrahigh doses of gentamicin and clinically relevant doses of neomycin affect inflammation and angiogenesis in in vivo and in vitro models.,,,, +492,,,,,"Biodegradable polyaspartamide (PASPAM) was grafted with several functional groups to implement diverse roles-octadecylamine (C 18 ) for nano-aggregate formation, dopamine (DOPA) for adhesive function, neomycin (NEO) for inhibition of bacterial infection.",,,, +493,,,,,Kaposi's sarcoma-associated herpesvirus-positive primary effusion lymphoma tumor formation in NOD/SCID mice is inhibited by neomycin and neamine blocking angiogenin's nuclear translocation.,,,, +494,,,,,Neomycin and the combination of neomycin and bacitracin in the prevention of bacterial infection in surgery of the colon and/or rectum.,,,, +495,,,,,Results of salvage therapy with mini-hyper-CVD and inotuzumab ozogamicin with or without blinatumomab in pre-B acute lymphoblastic leukemia.,,,, +496,,,,,"The impressive clinical success of the continuously intravenously infused T cell-redirecting bispecific antibody (T-bsAb) blinatumomab (anti-CD19 x anti-CD3), and of engineered T cells expressing anti-CD19 chimeric antigen receptors (CAR-T cells) in hematological malignancies, has led to renewed interest in a novel cancer immunotherapy strategy that combines features of antibody- and cell-based therapies.",,,, +497,,,,,Blinatumomab and inotuzumab ozogamycin represent promising alternatives to conventional chemotherapy in acute lymphoblastic leukaemia (ALL).,,,, +498,,,,,Efficacy of ciprofloxacin and dexamethasone in experimental pseudomonas endophthalmitis.,,,, +499,,,,,CONCLUSIONS: Combination therapy of adalimumab and ciprofloxacin is more effective than adalimumab monotherapy to achieve fistula closure in CD.,,,, +500,,,,,"Tested substances displayed inhibitory effect towards E. coli DNA gyrase, though less than ciprofloxacin.",,,, diff --git a/false_triple_data.csv b/false_triple_data.csv index 05b3782..7a90af8 100644 --- a/false_triple_data.csv +++ b/false_triple_data.csv @@ -1,500 +1,501 @@ -19572117,2,,related to,,Ciprofloxacin,,,,DNA Gyrase,,,,, -26452786,3,,causes,,Fenbendazole,,,,helminthiasis,,,,, -22762728,4,,prevents,,Fenbendazole,,,,helminthiasis,,,,, -21848143,5,,causes,,Albendazole,,,,helminthiasis,,,,, -25735916,6,,affects,,Albendazole,,,,trichuriasis,,,,, -24685635,7,,affects,,Albendazole,,,,filarial elephantiasis,,,,, -18452252,8,,affects,,Albendazole,,,,toxocariasis,,,,, -16658505,9,,affects,,Albendazole,,,,malaria,,,,, -13946207,10,,affects,,Albendazole,,,,helminthiasis,,,,, -11239060,11,,affects,,Albendazole,,,,filariasis,,,,, -24729219,12,,disrupts,,Albendazole,,,,helminthiasis,,,,, -16658503,13,,disrupts,,Albendazole,,,,malaria,,,,, -13637338,14,,disrupts,,Albendazole,,,,Hookworm Infections,,,,, -15248433,15,,prevents,,Albendazole,,,,filariasis,,,,, -13732336,16,,prevents,,Albendazole,,,,helminthiasis,,,,, -15316470,17,,subclass of,,Ibuprofen,,,,2-Hydroxyibuprofen,,,,, -16265626,18,,related to,,Ibuprofen,,,,Arthralgia,,,,, -14582794,19,,related to,,Ibuprofen,,,,Pain,,,,, -11440746,20,,related to,,Ibuprofen,,,,Toothache,,,,, -9106384,21,,related to,,Ibuprofen,,,,osteoarthritis,,,,, -8106985,22,,related to,,Ibuprofen,,,,burn,,,,, -13726345,23,,causes,,Ibuprofen,,,,patent ductus arteriosus,,,,, -13653982,24,,causes,,Ibuprofen,,,,Alzheimer disease,,,,, -13133316,25,,causes,,Ibuprofen,,,,peptic ulcer disease,,,,, -12641386,26,,causes,,Ibuprofen,,,,Fever,,,,, -12482174,27,,causes,,Ibuprofen,,,,pancreatitis,,,,, -12438812,28,,causes,,Ibuprofen,,,,Toothache,,,,, -12079834,29,,causes,,Ibuprofen,,,,adult acute respiratory distress syndrome,,,,, -11157616,30,,causes,,Ibuprofen,,,,Pain,,,,, -10429873,31,,causes,,Ibuprofen,,,,Hemorrhage,,,,, -9800201,32,,causes,,Ibuprofen,,,,arthritic joint disease,,,,, -8163776,33,,causes,,Ibuprofen,,,,injury,,,,, -26701175,34,,affects,,Ibuprofen,,,,rheumatoid arthritis,,,,, -24384432,35,,affects,,Ibuprofen,,,,migraine disorder,,,,, -23500890,36,,affects,,Ibuprofen,,,,adult acute respiratory distress syndrome,,,,, -21214366,37,,affects,,Ibuprofen,,,,bronchopulmonary dysplasia,,,,, -20886939,38,,affects,,Ibuprofen,,,,Cognitive impairment,,,,, -18977843,39,,affects,,Ibuprofen,,,,Headache,,,,, -15746938,40,,affects,,Ibuprofen,,,,injury,,,,, -13826486,41,,affects,,Ibuprofen,,,,osteoarthritis,,,,, -13584223,42,,affects,,Ibuprofen,,,,Cognitive impairment,,,,, -12659717,43,,affects,,Ibuprofen,,,,Fever,,,,, -11207850,44,,affects,,Ibuprofen,,,,peptic ulcer disease,,,,, -11159990,45,,affects,,Ibuprofen,,,,Hemorrhage,,,,, -10170540,46,,affects,,Ibuprofen,,,,patent ductus arteriosus,,,,, -10026104,47,,affects,,Ibuprofen,,,,Myalgia,,,,, -9889792,48,,affects,,Ibuprofen,,,,Hemorrhage,,,,, -8819538,49,,affects,,Ibuprofen,,,,osteoarthritis,,,,, -8421263,50,,affects,,Ibuprofen,,,,Fever,,,,, -27630106,51,,disrupts,,Ibuprofen,,,,Acute Pain,,,,, -23399675,52,,disrupts,,Ibuprofen,,,,Myalgia,,,,, -18599970,53,,disrupts,,Ibuprofen,,,,arthritic joint disease,,,,, -15072611,54,,disrupts,,Ibuprofen,,,,Fever,,,,, -14486259,55,,disrupts,,Ibuprofen,,,,Pain,,,,, -8331095,56,,disrupts,,Ibuprofen,,,,Alzheimer disease,,,,, -25657729,57,,prevents,,Ibuprofen,,,,hypertensive disorder,,,,, -22159382,58,,prevents,,Ibuprofen,,,,Hemorrhage,,,,, -22123299,59,,prevents,,Ibuprofen,,,,Fever,,,,, -21354514,60,,prevents,,Ibuprofen,,,,pancreatitis,,,,, -20691057,61,,prevents,,Ibuprofen,,,,altitude sickness,,,,, -19399624,62,,prevents,,Ibuprofen,,,,osteoarthritis,,,,, -17687542,63,,prevents,,Ibuprofen,,,,canker sore,,,,, -15961024,64,,prevents,,Ibuprofen,,,,Dysmenorrhea,,,,, -13710734,65,,prevents,,Ibuprofen,,,,Chronic pain,,,,, -10201705,66,,prevents,,Ibuprofen,,,,Headache,,,,, -10026105,67,,prevents,,Ibuprofen,,,,Myalgia,,,,, -9104502,68,,prevents,,Ibuprofen,,,,injury,,,,, -9022792,69,,prevents,,Ibuprofen,,,,Pain,,,,, -8584177,70,,prevents,,Ibuprofen,,,,patent ductus arteriosus,,,,, -7843138,71,,prevents,,Ibuprofen,,,,Alzheimer disease,,,,, -15342704,72,,exacerbates,,Ibuprofen,,,,injury,,,,, -20007370,73,,predisposes,,Ibuprofen,,,,cerebral palsy,,,,, -14332005,74,,predisposes,,Ibuprofen,,,,bronchopulmonary dysplasia,,,,, -14294004,75,,predisposes,,Ibuprofen,,,,Alzheimer disease,,,,, -14085648,76,,predisposes,,Ibuprofen,,,,injury,,,,, -12673407,77,,predisposes,,Ibuprofen,,,,bone fracture,,,,, -17604344,78,,related to,,Ivabradine,,,,diastolic heart failure,,,,, -19228519,79,,causes,,Ivabradine,,,,atrial fibrillation,,,,, -20784958,80,,affects,,Ivabradine,,,,atrial fibrillation,,,,, -20520107,81,,affects,,Ivabradine,,,,mitral valve stenosis,,,,, -20004006,82,,affects,,Ivabradine,,,,diastolic heart failure,,,,, -15323309,83,,affects,,Ivabradine,,,,cardiovascular disorder,,,,, -15323306,84,,affects,,Ivabradine,,,,coronary artery disorder,,,,, -19514713,85,,disrupts,,Ivabradine,,,,atrial fibrillation,,,,, -17909104,86,,disrupts,,Ivabradine,,,,coronary artery disorder,,,,, -17822394,87,,prevents,,Ivabradine,,,,atrial fibrillation,,,,, -10817471,88,,prevents,,Ivabradine,,,,Tachycardia,,,,, -19153602,89,,predisposes,,Ivabradine,,,,atrial fibrillation,,,,, -15385004,90,,affects,,Cefixime,,,,chronic bronchitis,,,,, -15252860,91,,affects,,Cefixime,,,,gonorrhea,,,,, -18811968,92,,prevents,,Cefixime,,,,otitis media,,,,, -17748395,93,,related to,,Trimetazidine,,,,diabetic kidney disease,,,,, -22426756,94,,affects,,Trimetazidine,,,,diabetic kidney disease,,,,, -21297588,95,,affects,,Trimetazidine,,,,Cardiotoxicity,,,,, -19164679,96,,affects,,Trimetazidine,,,,cardiovascular disorder,,,,, -18547788,97,,prevents,,Trimetazidine,,,,Cardiotoxicity,,,,, -13317799,98,,causes,,Ranolazine,,,,atrial fibrillation,,,,, -19314329,99,,affects,,Ranolazine,,,,cardiovascular disorder,,,,, -19002641,100,,affects,,Ranolazine,,,,atrial fibrillation,,,,, -17881291,101,,affects,,Ranolazine,,,,type 2 diabetes mellitus,,,,, -16599546,102,,affects,,Ranolazine,,,,atrial fibrillation,,,,, -15199166,103,,affects,,Ranolazine,,,,myocardial ischemia,,,,, -13887428,104,,disrupts,,Ranolazine,,,,atrial fibrillation,,,,, -17475563,105,,prevents,,Ranolazine,,,,Angina pectoris,,,,, -14751648,106,,prevents,,Ranolazine,,,,myocardial ischemia,,,,, -14280230,107,,prevents,,Ranolazine,,,,atrial fibrillation,,,,, -17988674,108,,predisposes,,Ranolazine,,,,atrial fibrillation,,,,, -26862829,109,,related to,,Prednisolone,,,,multiple sclerosis,,,,, -26365803,110,,related to,,Prednisolone,,,,adrenocortical insufficiency,,,,, -26295217,111,,related to,,Prednisolone,,,,angioimmunoblastic T-cell lymphoma,,,,, -26194122,112,,related to,,Prednisolone,,,,synovitis,,,,, -25959730,113,,related to,,Prednisolone,,,,sarcoma,,,,, -25621708,114,,related to,,Prednisolone,,,,uveitis,,,,, -24523226,115,,related to,,Prednisolone,,,,glomerulonephritis,,,,, -23496152,116,,related to,,Prednisolone,,,,subacute thyroiditis,,,,, -22194722,117,,related to,,Prednisolone,,,,pulmonary eosinophilia,,,,, -21911849,118,,related to,,Prednisolone,,,,habitual spontaneous abortion,,,,, -20512112,119,,related to,,Prednisolone,,,,castration-resistant prostate carcinoma,,,,, -20312000,120,,related to,,Prednisolone,,,,chronic primary adrenal insufficiency,,,,, -20106181,121,,related to,,Prednisolone,,,,allergic bronchopulmonary aspergillosis,,,,, -19750187,122,,related to,,Prednisolone,,,,lymphoma,,,,, -17143213,123,,related to,,Prednisolone,,,,temporal arteritis,,,,, -16983852,124,,related to,,Prednisolone,,,,Hodgkins lymphoma,,,,, -16960031,125,,related to,,Prednisolone,,,,psoriatic arthritis,,,,, -16502712,126,,related to,,Prednisolone,,,,aplastic anemia,,,,, -16371065,127,,related to,,Prednisolone,,,,celiac disease,,,,, -16192798,128,,related to,,Prednisolone,,,,dermatomyositis,,,,, -16169223,129,,related to,,Prednisolone,,,,mucocutaneous lymph node syndrome,,,,, -16114172,130,,related to,,Prednisolone,,,,plasma cell myeloma,,,,, -14564343,131,,related to,,Prednisolone,,,,acute lymphoblastic leukemia,,,,, -13988965,132,,related to,,Prednisolone,,,,osteoarthritis,,,,, -13151963,133,,related to,,Prednisolone,,,,diffuse large B-cell lymphoma,,,,, -13151962,134,,related to,,Prednisolone,,,,follicular lymphoma,,,,, -12983495,135,,related to,,Prednisolone,,,,prostate cancer,,,,, -12510603,136,,related to,,Prednisolone,,,,membranous glomerulonephritis,,,,, -12496746,137,,related to,,Prednisolone,,,,neoplasm,,,,, -12428137,138,,related to,,Prednisolone,,,,croup,,,,, -12061894,139,,related to,,Prednisolone,,,,West syndrome,,,,, -11663099,140,,related to,,Prednisolone,,,,Crohn disease,,,,, -11638013,141,,related to,,Prednisolone,,,,eosinophilic granulomatosis with polyangiitis,,,,, -11213963,142,,related to,,Prednisolone,,,,leprosy,,,,, -11179224,143,,related to,,Prednisolone,,,,alcoholic hepatitis,,,,, -11142916,144,,related to,,Prednisolone,,,,lupus nephritis,,,,, -11037266,145,,related to,,Prednisolone,,,,granulomatosis with polyangiitis,,,,, -11013570,146,,related to,,Prednisolone,,,,leukemia,,,,, -10949449,147,,related to,,Prednisolone,,,,polymyalgia rheumatica,,,,, -10748640,148,,related to,,Prednisolone,,,,infertility disorder,,,,, -10744705,149,,related to,,Prednisolone,,,,"dermatitis, atopic",,,,, -10736101,150,,related to,,Prednisolone,,,,Graves disease,,,,, -10735679,151,,related to,,Prednisolone,,,,kidney disorder,,,,, -10715297,152,,related to,,Prednisolone,,,,keratitis,,,,, -10703266,153,,related to,,Prednisolone,,,,ulcerative colitis,,,,, -10687782,154,,related to,,Prednisolone,,,,hepatocellular carcinoma,,,,, -10623724,155,,related to,,Prednisolone,,,,hemolytic anemia,,,,, -10576837,156,,related to,,Prednisolone,,,,juvenile idiopathic arthritis,,,,, -10565620,157,,related to,,Prednisolone,,,,nephrotic syndrome,,,,, -10531966,158,,related to,,Prednisolone,,,,allergic disease,,,,, -10527508,159,,related to,,Prednisolone,,,,acute myeloid leukemia,,,,, -10503828,160,,related to,,Prednisolone,,,,seasonal allergic rhinitis,,,,, -10496403,161,,related to,,Prednisolone,,,,Inflammation,,,,, -10118116,162,,related to,,Prednisolone,,,,Prednisone,,,,, -9924521,163,,related to,,Prednisolone,,,,colitis,,,,, -9437304,164,,related to,,Prednisolone,,,,systemic lupus erythematosus,,,,, -9282196,165,,related to,,Prednisolone,,,,IgA glomerulonephritis,,,,, -9222009,166,,related to,,Prednisolone,,,,hypereosinophilic syndrome,,,,, -9216084,167,,related to,,Prednisolone,,,,non-Hodgkin lymphoma,,,,, -9208405,168,,related to,,Prednisolone,,,,Duchenne muscular dystrophy,,,,, -8405261,169,,related to,,Prednisolone,,,,asthma,,,,, -7844202,170,,related to,,Prednisolone,,,,chronic obstructive pulmonary disease,,,,, -7323744,171,,related to,,Prednisolone,,,,pemphigus,,,,, -7262473,172,,related to,,Prednisolone,,,,rheumatoid arthritis,,,,, -7206314,173,,related to,,Prednisolone,,,,pulmonary tuberculosis,,,,, -8856354,174,,related to,,Prednisolone,,,,Prednisone,,,,, -26879702,175,,has part,,Prednisolone,,,,acute lymphoblastic leukemia,,,,, -26670577,176,,has part,,Prednisolone,,,,plasma cell myeloma,,,,, -18935086,177,,coexists with,,Prednisolone,,,,Prednisone,,,,, -9296680,178,,derives from,,Prednisolone,,,,Prednisone,,,,, -26415442,179,,derives from,,Prednisolone,,,,Prednisone,,,,, -14808035,180,,physically interacts with,,Prednisolone,,,,Prednisone,,,,, -9296682,181,,physically interacts with,,Prednisolone,,,,Prednisone,,,,, -27055840,182,,causes,,Prednisolone,,,,glaucoma,,,,, -26677891,183,,causes,,Prednisolone,,,,uveitis,,,,, -25953223,184,,causes,,Prednisolone,,,,kidney disorder,,,,, -21556285,185,,causes,,Prednisolone,,,,allergic disease,,,,, -21293782,186,,causes,,Prednisolone,,,,adrenocortical insufficiency,,,,, -20789636,187,,causes,,Prednisolone,,,,ulcerative colitis,,,,, -17230021,188,,causes,,Prednisolone,,,,Headache,,,,, -16304261,189,,causes,,Prednisolone,,,,nephrotic syndrome,,,,, -15365269,190,,causes,,Prednisolone,,,,infertility disorder,,,,, -14373522,191,,causes,,Prednisolone,,,,exfoliative dermatitis,,,,, -10735861,192,,causes,,Prednisolone,,,,contact dermatitis,,,,, -10545904,193,,causes,,Prednisolone,,,,pulmonary tuberculosis,,,,, -10519611,194,,causes,,Prednisolone,,,,colitis,,,,, -9464043,195,,causes,,Prednisolone,,,,cataract,,,,, -8757881,196,,causes,,Prednisolone,,,,systemic lupus erythematosus,,,,, -27658451,197,,affects,,Prednisolone,,,,uveitis,,,,, -27410586,198,,affects,,Prednisolone,,,,castration-resistant prostate carcinoma,,,,, -27323391,199,,affects,,Prednisolone,,,,focal segmental glomerulosclerosis,,,,, -27042309,200,,affects,,Prednisolone,,,,pulmonary eosinophilia,,,,, -25790510,201,,affects,,Prednisolone,,,,allergic disease,,,,, -25165576,202,,affects,,Prednisolone,,,,glomerulonephritis,,,,, -24270725,203,,affects,,Prednisolone,,,,dermatomyositis,,,,, -22922261,204,,affects,,Prednisolone,,,,allergic bronchopulmonary aspergillosis,,,,, -19824794,205,,affects,,Prednisolone,,,,colitis,,,,, -19409335,206,,affects,,Prednisolone,,,,sarcoidosis,,,,, -18736907,207,,affects,,Prednisolone,,,,asthma,,,,, -17668631,208,,affects,,Prednisolone,,,,Prednisone,,,,, -15888410,209,,affects,,Prednisolone,,,,rheumatoid arthritis,,,,, -13564625,210,,affects,,Prednisolone,,,,asthma,,,,, -13234063,211,,affects,,Prednisolone,,,,pericarditis,,,,, -13029310,212,,affects,,Prednisolone,,,,chronic obstructive pulmonary disease,,,,, -12949384,213,,affects,,Prednisolone,,,,hypereosinophilic syndrome,,,,, -12057849,214,,affects,,Prednisolone,,,,Crohn disease,,,,, -11166436,215,,affects,,Prednisolone,,,,Headache,,,,, -11074135,216,,affects,,Prednisolone,,,,lymphoma,,,,, -10651502,217,,affects,,Prednisolone,,,,kidney disorder,,,,, -10649036,218,,affects,,Prednisolone,,,,chorioretinitis,,,,, -10555139,219,,affects,,Prednisolone,,,,peptic ulcer disease,,,,, -10183156,220,,affects,,Prednisolone,,,,ulcerative colitis,,,,, -9735520,221,,affects,,Prednisolone,,,,Inflammation,,,,, -9361682,222,,affects,,Prednisolone,,,,osteoarthritis,,,,, -8533593,223,,affects,,Prednisolone,,,,neoplasm,,,,, -7800426,224,,affects,,Prednisolone,,,,acute lymphoblastic leukemia,,,,, -7395227,225,,affects,,Prednisolone,,,,systemic lupus erythematosus,,,,, -21722189,226,,affects,,Prednisolone,,,,Prednisone,,,,, -9655099,227,,has input,,Prednisolone,,,,Prednisone,,,,, -27206106,228,,disrupts,,Prednisolone,,,,uveitis,,,,, -26515767,229,,disrupts,,Prednisolone,,,,neoplasm,,,,, -26379811,230,,disrupts,,Prednisolone,,,,contact dermatitis,,,,, -25763558,231,,disrupts,,Prednisolone,,,,pneumonia,,,,, -25233555,232,,disrupts,,Prednisolone,,,,allergic disease,,,,, -14331279,233,,disrupts,,Prednisolone,,,,hypereosinophilic syndrome,,,,, -10594561,234,,disrupts,,Prednisolone,,,,asthma,,,,, -8854473,235,,disrupts,,Prednisolone,,,,Inflammation,,,,, -27646185,236,,prevents,,Prednisolone,,,,allergic disease,,,,, -26227245,237,,prevents,,Prednisolone,,,,synovitis,,,,, -19453072,238,,prevents,,Prednisolone,,,,hypereosinophilic syndrome,,,,, -16706850,239,,prevents,,Prednisolone,,,,neoplasm,,,,, -15809068,240,,prevents,,Prednisolone,,,,colitis,,,,, -11858005,241,,prevents,,Prednisolone,,,,asthma,,,,, -10983909,242,,prevents,,Prednisolone,,,,leprosy,,,,, -10240036,243,,prevents,,Prednisolone,,,,Inflammation,,,,, -18452194,244,,exacerbates,,Prednisolone,,,,ulcerative colitis,,,,, -25753407,245,,predisposes,,Prednisolone,,,,neoplasm,,,,, -16546227,246,,predisposes,,Prednisolone,,,,pneumonia,,,,, -27027571,247,,related to,,Hydrocortisone,,,,HIV infectious disease,,,,, -25927636,248,,related to,,Hydrocortisone,,,,cardiac arrest,,,,, -25797574,249,,related to,,Hydrocortisone,,,,lymphoma,,,,, -25131277,250,,related to,,Hydrocortisone,,,,Crohn disease,,,,, -19793698,251,,related to,,Hydrocortisone,,,,alcohol abuse,,,,, -19531872,252,,related to,,Hydrocortisone,,,,atrial fibrillation,,,,, -18705900,253,,related to,,Hydrocortisone,,,,phobic disorder,,,,, -15155784,254,,related to,,Hydrocortisone,,,,psoriasis,,,,, -14891361,255,,related to,,Hydrocortisone,,,,"dermatitis, atopic",,,,, -14483328,256,,related to,,Hydrocortisone,,,,bronchopulmonary dysplasia,,,,, -14450267,257,,related to,,Hydrocortisone,,,,adrenal cortex neoplasm,,,,, -14387016,258,,related to,,Hydrocortisone,,,,cirrhosis of liver,,,,, -14360687,259,,related to,,Hydrocortisone,,,,dermatitis,,,,, -13844584,260,,related to,,Hydrocortisone,,,,acute myeloid leukemia,,,,, -13213365,261,,related to,,Hydrocortisone,,,,chronic primary adrenal insufficiency,,,,, -12756660,262,,related to,,Hydrocortisone,,,,borderline personality disorder,,,,, -12576998,263,,related to,,Hydrocortisone,,,,Hypoxemia,,,,, -11888652,264,,related to,,Hydrocortisone,,,,congenital adrenal hyperplasia,,,,, -11866289,265,,related to,,Hydrocortisone,,,,nicotine dependence,,,,, -11530989,266,,related to,,Hydrocortisone,,,,pneumonia,,,,, -11442939,267,,related to,,Hydrocortisone,,,,prostate cancer,,,,, -11089023,268,,related to,,Hydrocortisone,,,,pancreatitis,,,,, -10649902,269,,related to,,Hydrocortisone,,,,myocardial infarction,,,,, -10522181,270,,related to,,Hydrocortisone,,,,osteoarthritis,,,,, -10521296,271,,related to,,Hydrocortisone,,,,eye disorder,,,,, -10518203,272,,related to,,Hydrocortisone,,,,otitis externa,,,,, -10484611,273,,related to,,Hydrocortisone,,,,ulcerative colitis,,,,, -9718673,274,,related to,,Hydrocortisone,,,,atopic eczema,,,,, -9492934,275,,related to,,Hydrocortisone,,,,opiate dependence,,,,, -9238280,276,,related to,,Hydrocortisone,,,,Sepsis,,,,, -9235597,277,,related to,,Hydrocortisone,,,,type 1 diabetes mellitus,,,,, -8977987,278,,related to,,Hydrocortisone,,,,injury,,,,, -8778414,279,,related to,,Hydrocortisone,,,,Inflammation,,,,, -8763179,280,,related to,,Hydrocortisone,,,,toxic shock syndrome,,,,, -8625521,281,,related to,,Hydrocortisone,,,,dissociative amnesia,,,,, -8615164,282,,related to,,Hydrocortisone,,,,asthma,,,,, -8570630,283,,related to,,Hydrocortisone,,,,fibromyalgia,,,,, -8017438,284,,related to,,Hydrocortisone,,,,Insulin resistance,,,,, -7919367,285,,related to,,Hydrocortisone,,,,adrenocortical insufficiency,,,,, -7573954,286,,related to,,Hydrocortisone,,,,neoplasm,,,,, -7182905,287,,related to,,Hydrocortisone,,,,obesity disorder,,,,, -24445107,288,,related to,,Hydrocortisone,,,,Inflammation,,,,, -24030854,289,,related to,,Hydrocortisone,,,,Hypoxemia,,,,, -12533519,290,,related to,,Hydrocortisone,,,,Insulin resistance,,,,, -27747116,291,,causes,,Hydrocortisone,,,,toxic shock syndrome,,,,, -27747115,292,,causes,,Hydrocortisone,,,,Sepsis,,,,, -27073884,293,,causes,,Hydrocortisone,,,,atopic eczema,,,,, -25383174,294,,causes,,Hydrocortisone,,,,fibromyalgia,,,,, -25205462,295,,causes,,Hydrocortisone,,,,hypotensive disorder,,,,, -20591759,296,,causes,,Hydrocortisone,,,,Hypoxemia,,,,, -18446972,297,,causes,,Hydrocortisone,,,,congenital adrenal hyperplasia,,,,, -18240145,298,,causes,,Hydrocortisone,,,,injury,,,,, -17359303,299,,causes,,Hydrocortisone,,,,influenza,,,,, -13585273,300,,causes,,Hydrocortisone,,,,"dermatitis, atopic",,,,, -12645476,301,,causes,,Hydrocortisone,,,,obesity disorder,,,,, -10068843,302,,causes,,Hydrocortisone,,,,Inflammation,,,,, -9850315,303,,causes,,Hydrocortisone,,,,dissociative amnesia,,,,, -9318796,304,,causes,,Hydrocortisone,,,,adrenocortical insufficiency,,,,, -9145908,305,,causes,,Hydrocortisone,,,,otitis externa,,,,, -8699464,306,,causes,,Hydrocortisone,,,,adrenal cortex neoplasm,,,,, -8657746,307,,causes,,Hydrocortisone,,,,neoplasm,,,,, -7929803,308,,causes,,Hydrocortisone,,,,Insulin resistance,,,,, -7432490,309,,causes,,Hydrocortisone,,,,pancreatitis,,,,, -26997315,310,,affects,,Hydrocortisone,,,,congenital adrenal hyperplasia,,,,, -26940919,311,,affects,,Hydrocortisone,,,,cardiac arrest,,,,, -26840479,312,,affects,,Hydrocortisone,,,,myocardial infarction,,,,, -24701128,313,,affects,,Hydrocortisone,,,,Sepsis,,,,, -21274202,314,,affects,,Hydrocortisone,,,,osteoarthritis,,,,, -20701310,315,,affects,,Hydrocortisone,,,,psoriasis,,,,, -20336537,316,,affects,,Hydrocortisone,,,,dermatitis,,,,, -20137862,317,,affects,,Hydrocortisone,,,,fibromyalgia,,,,, -19555227,318,,affects,,Hydrocortisone,,,,pneumonia,,,,, -19531871,319,,affects,,Hydrocortisone,,,,atrial fibrillation,,,,, -18495054,320,,affects,,Hydrocortisone,,,,lymphoma,,,,, -18495053,321,,affects,,Hydrocortisone,,,,leukemia,,,,, -18310128,322,,affects,,Hydrocortisone,,,,toxic shock syndrome,,,,, -17910566,323,,affects,,Hydrocortisone,,,,atopic eczema,,,,, -15925719,324,,affects,,Hydrocortisone,,,,Inflammation,,,,, -14970164,325,,affects,,Hydrocortisone,,,,Insulin resistance,,,,, -14804311,326,,affects,,Hydrocortisone,,,,injury,,,,, -14533429,327,,affects,,Hydrocortisone,,,,hypotensive disorder,,,,, -13999195,328,,affects,,Hydrocortisone,,,,congenital adrenal hyperplasia,,,,, -13347553,329,,affects,,Hydrocortisone,,,,asthma,,,,, -13180935,330,,affects,,Hydrocortisone,,,,hypotensive disorder,,,,, -11695335,331,,affects,,Hydrocortisone,,,,Hypoxemia,,,,, -11304252,332,,affects,,Hydrocortisone,,,,obesity disorder,,,,, -10523644,333,,affects,,Hydrocortisone,,,,injury,,,,, -10431364,334,,affects,,Hydrocortisone,,,,Inflammation,,,,, -10074536,335,,affects,,Hydrocortisone,,,,HIV infectious disease,,,,, -9872405,336,,affects,,Hydrocortisone,,,,toxic shock syndrome,,,,, -9610203,337,,affects,,Hydrocortisone,,,,neoplasm,,,,, -9120606,338,,affects,,Hydrocortisone,,,,asthma,,,,, -8017440,339,,affects,,Hydrocortisone,,,,obesity disorder,,,,, -7974249,340,,affects,,Hydrocortisone,,,,Insulin resistance,,,,, -7366981,341,,affects,,Hydrocortisone,,,,Hypoxemia,,,,, -7266667,342,,affects,,Hydrocortisone,,,,dissociative amnesia,,,,, -27426083,343,,produces,,Hydrocortisone,,,,HIV infectious disease,,,,, -24427531,344,,produces,,Hydrocortisone,,,,cirrhosis of liver,,,,, -23738730,345,,produces,,Hydrocortisone,,,,congenital adrenal hyperplasia,,,,, -20514012,346,,produces,,Hydrocortisone,,,,"dermatitis, atopic",,,,, -18924640,347,,produces,,Hydrocortisone,,,,Inflammation,,,,, -16473285,348,,produces,,Hydrocortisone,,,,type 1 diabetes mellitus,,,,, -15760263,349,,produces,,Hydrocortisone,,,,toxic shock syndrome,,,,, -15330155,350,,produces,,Hydrocortisone,,,,chronic primary adrenal insufficiency,,,,, -14100936,351,,produces,,Hydrocortisone,,,,Insulin resistance,,,,, -13891079,352,,produces,,Hydrocortisone,,,,obesity disorder,,,,, -13796050,353,,produces,,Hydrocortisone,,,,adrenal cortex neoplasm,,,,, -13783969,354,,produces,,Hydrocortisone,,,,adrenocortical insufficiency,,,,, -13669597,355,,produces,,Hydrocortisone,,,,asthma,,,,, -12147996,356,,produces,,Hydrocortisone,,,,Sepsis,,,,, -11989948,357,,produces,,Hydrocortisone,,,,Hypoxemia,,,,, -11730055,358,,produces,,Hydrocortisone,,,,pneumonia,,,,, -8328567,359,,produces,,Hydrocortisone,,,,prostate cancer,,,,, -8077250,360,,produces,,Hydrocortisone,,,,neoplasm,,,,, -27711985,361,,disrupts,,Hydrocortisone,,,,adrenocortical insufficiency,,,,, -26428860,362,,disrupts,,Hydrocortisone,,,,leukemia,,,,, -26389045,363,,disrupts,,Hydrocortisone,,,,neoplasm,,,,, -26128287,364,,disrupts,,Hydrocortisone,,,,melanoma,,,,, -21020907,365,,disrupts,,Hydrocortisone,,,,pneumonia,,,,, -15895489,366,,disrupts,,Hydrocortisone,,,,obesity disorder,,,,, -15750557,367,,disrupts,,Hydrocortisone,,,,injury,,,,, -8865955,368,,disrupts,,Hydrocortisone,,,,Inflammation,,,,, -26205555,369,,prevents,,Hydrocortisone,,,,neoplasm,,,,, -19342068,370,,prevents,,Hydrocortisone,,,,obesity disorder,,,,, -19245686,371,,prevents,,Hydrocortisone,,,,toxic shock syndrome,,,,, -18758297,372,,prevents,,Hydrocortisone,,,,injury,,,,, -17956690,373,,prevents,,Hydrocortisone,,,,Sepsis,,,,, -16963888,374,,prevents,,Hydrocortisone,,,,adrenocortical insufficiency,,,,, -15550113,375,,prevents,,Hydrocortisone,,,,Inflammation,,,,, -15540854,376,,prevents,,Hydrocortisone,,,,pneumonia,,,,, -14020540,377,,prevents,,Hydrocortisone,,,,bronchopulmonary dysplasia,,,,, -13075196,378,,prevents,,Hydrocortisone,,,,atrial fibrillation,,,,, -12187318,379,,prevents,,Hydrocortisone,,,,Insulin resistance,,,,, -14643692,380,,exacerbates,,Hydrocortisone,,,,Sepsis,,,,, -8122784,381,,exacerbates,,Hydrocortisone,,,,obesity disorder,,,,, -25411585,382,,predisposes,,Hydrocortisone,,,,atrial fibrillation,,,,, -19755964,383,,predisposes,,Hydrocortisone,,,,Sepsis,,,,, -13712588,384,,predisposes,,Hydrocortisone,,,,injury,,,,, -12555774,385,,predisposes,,Hydrocortisone,,,,toxic shock syndrome,,,,, -11782928,386,,predisposes,,Hydrocortisone,,,,Inflammation,,,,, -10520517,387,,predisposes,,Hydrocortisone,,,,obesity disorder,,,,, -8615556,388,,predisposes,,Hydrocortisone,,,,dissociative amnesia,,,,, -8552834,389,,predisposes,,Hydrocortisone,,,,asthma,,,,, -8002300,390,,predisposes,,Hydrocortisone,,,,Insulin resistance,,,,, -7960726,391,,predisposes,,Hydrocortisone,,,,pneumonia,,,,, -27228384,392,,related to,,Methylprednisolone,,,,Crohn disease,,,,, -26974005,393,,related to,,Methylprednisolone,,,,hematopoietic and lymphoid system neoplasm,,,,, -26513818,394,,related to,,Methylprednisolone,,,,B-cell chronic lymphocytic leukemia,,,,, -26050805,395,,related to,,Methylprednisolone,,,,ankylosing spondylitis,,,,, -25845844,396,,related to,,Methylprednisolone,,,,breast neoplasm,,,,, -25642837,397,,related to,,Methylprednisolone,,,,dermatomyositis,,,,, -25328503,398,,related to,,Methylprednisolone,,,,Meniere disease,,,,, -24759961,399,,related to,,Methylprednisolone,,,,non-Hodgkin lymphoma,,,,, -24691450,400,,related to,,Methylprednisolone,,,,plantar fasciitis,,,,, -24586108,401,,related to,,Methylprednisolone,,,,alcoholic hepatitis,,,,, -24559507,402,,related to,,Methylprednisolone,,,,respiratory system disorder,,,,, -23573980,403,,related to,,Methylprednisolone,,,,pneumonia,,,,, -23514846,404,,related to,,Methylprednisolone,,,,carpal tunnel syndrome,,,,, -23364897,405,,related to,,Methylprednisolone,,,,West syndrome,,,,, -22495910,406,,related to,,Methylprednisolone,,,,myocarditis,,,,, -22175056,407,,related to,,Methylprednisolone,,,,myopathy,,,,, -20879022,408,,related to,,Methylprednisolone,,,,Pain,,,,, -20342058,409,,related to,,Methylprednisolone,,,,chronic progressive multiple sclerosis,,,,, -20290784,410,,related to,,Methylprednisolone,,,,membranous glomerulonephritis,,,,, -20286711,411,,related to,,Methylprednisolone,,,,neuromyelitis optica,,,,, -19340184,412,,related to,,Methylprednisolone,,,,chronic obstructive pulmonary disease,,,,, -18938435,413,,related to,,Methylprednisolone,,,,graft versus host disease,,,,, -17333962,414,,related to,,Methylprednisolone,,,,Inflammation,,,,, -17288506,415,,related to,,Methylprednisolone,,,,autoimmune thrombocytopenic purpura,,,,, -15936572,416,,related to,,Methylprednisolone,,,,endocrine exophthalmos,,,,, -15072844,417,,related to,,Methylprednisolone,,,,Edema,,,,, -14876749,418,,related to,,Methylprednisolone,,,,osteoarthritis,,,,, -14399082,419,,related to,,Methylprednisolone,,,,aplastic anemia,,,,, -14398237,420,,related to,,Methylprednisolone,,,,IgA glomerulonephritis,,,,, -14278238,421,,related to,,Methylprednisolone,,,,"dermatitis, atopic",,,,, -14166179,422,,related to,,Methylprednisolone,,,,cardiac arrest,,,,, -12755316,423,,related to,,Methylprednisolone,,,,plasma cell myeloma,,,,, -12183687,424,,related to,,Methylprednisolone,,,,acute lymphoblastic leukemia,,,,, -11720471,425,,related to,,Methylprednisolone,,,,systemic lupus erythematosus,,,,, -10812685,426,,related to,,Methylprednisolone,,,,immunoglobulin a vasculitis,,,,, -10763477,427,,related to,,Methylprednisolone,,,,ulcerative colitis,,,,, -10558884,428,,related to,,Methylprednisolone,,,,lupus nephritis,,,,, -10130342,429,,related to,,Methylprednisolone,,,,adult acute respiratory distress syndrome,,,,, -9229208,430,,related to,,Methylprednisolone,,,,vestibular neuronitis,,,,, -9003326,431,,related to,,Methylprednisolone,,,,systemic sclerosis,,,,, -8447481,432,,related to,,Methylprednisolone,,,,rheumatoid arthritis,,,,, -8282330,433,,related to,,Methylprednisolone,,,,spinal cord injury,,,,, -7944646,434,,related to,,Methylprednisolone,,,,myasthenia gravis,,,,, -7668599,435,,related to,,Methylprednisolone,,,,multiple sclerosis,,,,, -7443745,436,,related to,,Methylprednisolone,,,,asthma,,,,, -24973247,437,,causes,,Methylprednisolone,,,,lupus nephritis,,,,, -24161886,438,,causes,,Methylprednisolone,,,,Edema,,,,, -18534953,439,,causes,,Methylprednisolone,,,,Inflammation,,,,, -18260665,440,,causes,,Methylprednisolone,,,,neoplasm,,,,, -17307095,441,,causes,,Methylprednisolone,,,,pneumonia,,,,, -15906641,442,,causes,,Methylprednisolone,,,,Pain,,,,, -13166073,443,,causes,,Methylprednisolone,,,,thrombocytopenia,,,,, -12672767,444,,causes,,Methylprednisolone,,,,drug-induced liver injury,,,,, -8525599,445,,causes,,Methylprednisolone,,,,myopathy,,,,, -27357949,446,,affects,,Methylprednisolone,,,,neoplasm,,,,, -24420470,447,,affects,,Methylprednisolone,,,,Inflammation,,,,, -23472756,448,,affects,,Methylprednisolone,,,,Inflammation,,,,, -20530617,449,,affects,,Methylprednisolone,,,,systemic sclerosis,,,,, -20254789,450,,affects,,Methylprednisolone,,,,adult acute respiratory distress syndrome,,,,, -17649050,451,,affects,,Methylprednisolone,,,,optic nerve disorder,,,,, -16634377,452,,affects,,Methylprednisolone,,,,myasthenia gravis,,,,, -16277488,453,,affects,,Methylprednisolone,,,,neuromyelitis optica,,,,, -15906642,454,,affects,,Methylprednisolone,,,,Pain,,,,, -15610554,455,,affects,,Methylprednisolone,,,,rheumatoid arthritis,,,,, -15186368,456,,affects,,Methylprednisolone,,,,graft versus host disease,,,,, -14891106,457,,affects,,Methylprednisolone,,,,kidney disorder,,,,, -11819955,458,,affects,,Methylprednisolone,,,,spinal cord injury,,,,, -10845505,459,,affects,,Methylprednisolone,,,,Pain,,,,, -10048898,460,,affects,,Methylprednisolone,,,,ulcerative colitis,,,,, -9646753,461,,affects,,Methylprednisolone,,,,multiple sclerosis,,,,, -9346353,462,,affects,,Methylprednisolone,,,,chronic obstructive pulmonary disease,,,,, -9107378,463,,affects,,Methylprednisolone,,,,Edema,,,,, -8596544,464,,affects,,Methylprednisolone,,,,asthma,,,,, -8330909,465,,affects,,Methylprednisolone,,,,systemic lupus erythematosus,,,,, -19744632,466,,disrupts,,Methylprednisolone,,,,Edema,,,,, -18407557,467,,disrupts,,Methylprednisolone,,,,thrombocytopenia,,,,, -11106658,468,,disrupts,,Methylprednisolone,,,,Pain,,,,, -8640603,469,,disrupts,,Methylprednisolone,,,,Inflammation,,,,, -23934495,470,,prevents,,Methylprednisolone,,,,Cognitive impairment,,,,, -20014108,471,,prevents,,Methylprednisolone,,,,rheumatoid arthritis,,,,, -18266414,472,,prevents,,Methylprednisolone,,,,Abdominal pain,,,,, -14967074,473,,prevents,,Methylprednisolone,,,,asthma,,,,, -9744990,474,,prevents,,Methylprednisolone,,,,ovarian hyperstimulation syndrome,,,,, -8345063,475,,prevents,,Methylprednisolone,,,,Pain,,,,, -8291272,476,,prevents,,Methylprednisolone,,,,graft versus host disease,,,,, -7980138,477,,prevents,,Methylprednisolone,,,,spinal cord injury,,,,, -7414405,478,,prevents,,Methylprednisolone,,,,Edema,,,,, -18106042,479,,predisposes,,Methylprednisolone,,,,pneumonia,,,,, -9645180,480,,predisposes,,Methylprednisolone,,,,Inflammation,,,,, -12905337,481,,related to,,Cefotaxime,,,,Sepsis,,,,, -24475300,482,,affects,,Cefotaxime,,,,bacterial infectious disease,,,,, -23922029,483,,affects,,Cefotaxime,,,,Sepsis,,,,, -18672205,484,,affects,,Cefotaxime,,,,peritonitis,,,,, -15853591,485,,prevents,,Cefotaxime,,,,Sepsis,,,,, -19081412,486,,prevents,,Ceftriaxone,,,,bacterial infectious disease,,,,, -25827448,487,,related to,,Gefarnate,,,,gastric ulcer,,,,, -24296137,488,,related to,,Gefarnate,,,,duodenal ulcer,,,,, -25993651,489,,disrupts,,Gefarnate,,,,gastric ulcer,,,,, -17758516,490,,related to,,Neobiotic,,,,Inflammation,,,,, -10690423,491,,related to,,Neobiotic,,,,burn,,,,, -20263460,492,,affects,,Neobiotic,,,,neoplasm,,,,, -19744068,493,,affects,,Neobiotic,,,,Inflammation,,,,, -24669492,494,,disrupts,,Neobiotic,,,,bacterial infectious disease,,,,, -17119153,495,,disrupts,,Neobiotic,,,,neoplasm,,,,, -26428369,496,,prevents,,Neobiotic,,,,bacterial infectious disease,,,,, -25579460,497,,related to,,BLINATUMOMAB,,,,Precursor B-Cell Lymphoblastic Leukemia-Lymphoma,,,,, -22474123,498,,related to,,BLINATUMOMAB,,,,hematopoietic and lymphoid system neoplasm,,,,, -21947892,499,,related to,,BLINATUMOMAB,,,,acute lymphoblastic leukemia,,,,, -27155094,500,,related to,,Ciprofloxacin,,,,endophthalmitis,,,,, -16836665,501,,related to,,Ciprofloxacin,,,,Crohn disease,,,,, +PREDICATION_ID,SENTENCE_ID,PMID,PREDICATE,SUBJECT_CUI,SUBJECT_NAME,SUBJECT_SEMTYPE,SUBJECT_NOVELTY,OBJECT_CUI,OBJECT_NAME,OBJECT_SEMTYPE,OBJECT_NOVELTY,Column,Column,Column +26452786,101,,causes,,Fenbendazole,,,,helminthiasis,,,,, +22762728,102,,prevents,,Fenbendazole,,,,helminthiasis,,,,, +21848143,103,,causes,,Albendazole,,,,helminthiasis,,,,, +25735916,104,,affects,,Albendazole,,,,trichuriasis,,,,, +24685635,105,,affects,,Albendazole,,,,filarial elephantiasis,,,,, +18452252,106,,affects,,Albendazole,,,,toxocariasis,,,,, +16658505,107,,affects,,Albendazole,,,,malaria,,,,, +13946207,108,,affects,,Albendazole,,,,helminthiasis,,,,, +11239060,109,,affects,,Albendazole,,,,filariasis,,,,, +24729219,110,,disrupts,,Albendazole,,,,helminthiasis,,,,, +16658503,111,,disrupts,,Albendazole,,,,malaria,,,,, +13637338,112,,disrupts,,Albendazole,,,,Hookworm Infections,,,,, +15248433,113,,prevents,,Albendazole,,,,filariasis,,,,, +13732336,114,,prevents,,Albendazole,,,,helminthiasis,,,,, +15316470,115,,subclass of,,Ibuprofen,,,,2-Hydroxyibuprofen,,,,, +16265626,116,,related to,,Ibuprofen,,,,Arthralgia,,,,, +14582794,117,,related to,,Ibuprofen,,,,Pain,,,,, +11440746,118,,related to,,Ibuprofen,,,,Toothache,,,,, +9106384,119,,related to,,Ibuprofen,,,,osteoarthritis,,,,, +8106985,120,,related to,,Ibuprofen,,,,burn,,,,, +13726345,121,,causes,,Ibuprofen,,,,patent ductus arteriosus,,,,, +13653982,122,,causes,,Ibuprofen,,,,Alzheimer disease,,,,, +13133316,123,,causes,,Ibuprofen,,,,peptic ulcer disease,,,,, +12641386,124,,causes,,Ibuprofen,,,,Fever,,,,, +12482174,125,,causes,,Ibuprofen,,,,pancreatitis,,,,, +12438812,126,,causes,,Ibuprofen,,,,Toothache,,,,, +12079834,127,,causes,,Ibuprofen,,,,adult acute respiratory distress syndrome,,,,, +11157616,128,,causes,,Ibuprofen,,,,Pain,,,,, +10429873,129,,causes,,Ibuprofen,,,,Hemorrhage,,,,, +9800201,130,,causes,,Ibuprofen,,,,arthritic joint disease,,,,, +8163776,131,,causes,,Ibuprofen,,,,injury,,,,, +26701175,132,,affects,,Ibuprofen,,,,rheumatoid arthritis,,,,, +24384432,133,,affects,,Ibuprofen,,,,migraine disorder,,,,, +23500890,134,,affects,,Ibuprofen,,,,adult acute respiratory distress syndrome,,,,, +21214366,135,,affects,,Ibuprofen,,,,bronchopulmonary dysplasia,,,,, +20886939,136,,affects,,Ibuprofen,,,,Cognitive impairment,,,,, +18977843,137,,affects,,Ibuprofen,,,,Headache,,,,, +15746938,138,,affects,,Ibuprofen,,,,injury,,,,, +13826486,139,,affects,,Ibuprofen,,,,osteoarthritis,,,,, +13584223,140,,affects,,Ibuprofen,,,,Cognitive impairment,,,,, +12659717,141,,affects,,Ibuprofen,,,,Fever,,,,, +11207850,142,,affects,,Ibuprofen,,,,peptic ulcer disease,,,,, +11159990,143,,affects,,Ibuprofen,,,,Hemorrhage,,,,, +10170540,144,,affects,,Ibuprofen,,,,patent ductus arteriosus,,,,, +10026104,145,,affects,,Ibuprofen,,,,Myalgia,,,,, +9889792,146,,affects,,Ibuprofen,,,,Hemorrhage,,,,, +8819538,147,,affects,,Ibuprofen,,,,osteoarthritis,,,,, +8421263,148,,affects,,Ibuprofen,,,,Fever,,,,, +27630106,149,,disrupts,,Ibuprofen,,,,Acute Pain,,,,, +23399675,150,,disrupts,,Ibuprofen,,,,Myalgia,,,,, +18599970,151,,disrupts,,Ibuprofen,,,,arthritic joint disease,,,,, +15072611,152,,disrupts,,Ibuprofen,,,,Fever,,,,, +14486259,153,,disrupts,,Ibuprofen,,,,Pain,,,,, +8331095,154,,disrupts,,Ibuprofen,,,,Alzheimer disease,,,,, +25657729,155,,prevents,,Ibuprofen,,,,hypertensive disorder,,,,, +22159382,156,,prevents,,Ibuprofen,,,,Hemorrhage,,,,, +22123299,157,,prevents,,Ibuprofen,,,,Fever,,,,, +21354514,158,,prevents,,Ibuprofen,,,,pancreatitis,,,,, +20691057,159,,prevents,,Ibuprofen,,,,altitude sickness,,,,, +19399624,160,,prevents,,Ibuprofen,,,,osteoarthritis,,,,, +17687542,161,,prevents,,Ibuprofen,,,,canker sore,,,,, +15961024,162,,prevents,,Ibuprofen,,,,Dysmenorrhea,,,,, +13710734,163,,prevents,,Ibuprofen,,,,Chronic pain,,,,, +10201705,164,,prevents,,Ibuprofen,,,,Headache,,,,, +10026105,165,,prevents,,Ibuprofen,,,,Myalgia,,,,, +9104502,166,,prevents,,Ibuprofen,,,,injury,,,,, +9022792,167,,prevents,,Ibuprofen,,,,Pain,,,,, +8584177,168,,prevents,,Ibuprofen,,,,patent ductus arteriosus,,,,, +7843138,169,,prevents,,Ibuprofen,,,,Alzheimer disease,,,,, +15342704,170,,exacerbates,,Ibuprofen,,,,injury,,,,, +20007370,171,,predisposes,,Ibuprofen,,,,cerebral palsy,,,,, +14332005,172,,predisposes,,Ibuprofen,,,,bronchopulmonary dysplasia,,,,, +14294004,173,,predisposes,,Ibuprofen,,,,Alzheimer disease,,,,, +14085648,174,,predisposes,,Ibuprofen,,,,injury,,,,, +12673407,175,,predisposes,,Ibuprofen,,,,bone fracture,,,,, +17604344,176,,related to,,Ivabradine,,,,diastolic heart failure,,,,, +19228519,177,,causes,,Ivabradine,,,,atrial fibrillation,,,,, +20784958,178,,affects,,Ivabradine,,,,atrial fibrillation,,,,, +20520107,179,,affects,,Ivabradine,,,,mitral valve stenosis,,,,, +20004006,180,,affects,,Ivabradine,,,,diastolic heart failure,,,,, +15323309,181,,affects,,Ivabradine,,,,cardiovascular disorder,,,,, +15323306,182,,affects,,Ivabradine,,,,coronary artery disorder,,,,, +19514713,183,,disrupts,,Ivabradine,,,,atrial fibrillation,,,,, +17909104,184,,disrupts,,Ivabradine,,,,coronary artery disorder,,,,, +17822394,185,,prevents,,Ivabradine,,,,atrial fibrillation,,,,, +10817471,186,,prevents,,Ivabradine,,,,Tachycardia,,,,, +19153602,187,,predisposes,,Ivabradine,,,,atrial fibrillation,,,,, +15385004,188,,affects,,Cefixime,,,,chronic bronchitis,,,,, +15252860,189,,affects,,Cefixime,,,,gonorrhea,,,,, +18811968,190,,prevents,,Cefixime,,,,otitis media,,,,, +17748395,191,,related to,,Trimetazidine,,,,diabetic kidney disease,,,,, +22426756,192,,affects,,Trimetazidine,,,,diabetic kidney disease,,,,, +21297588,193,,affects,,Trimetazidine,,,,Cardiotoxicity,,,,, +19164679,194,,affects,,Trimetazidine,,,,cardiovascular disorder,,,,, +18547788,195,,prevents,,Trimetazidine,,,,Cardiotoxicity,,,,, +13317799,196,,causes,,Ranolazine,,,,atrial fibrillation,,,,, +19314329,197,,affects,,Ranolazine,,,,cardiovascular disorder,,,,, +19002641,198,,affects,,Ranolazine,,,,atrial fibrillation,,,,, +17881291,199,,affects,,Ranolazine,,,,type 2 diabetes mellitus,,,,, +16599546,200,,affects,,Ranolazine,,,,atrial fibrillation,,,,, +15199166,201,,affects,,Ranolazine,,,,myocardial ischemia,,,,, +13887428,202,,disrupts,,Ranolazine,,,,atrial fibrillation,,,,, +17475563,203,,prevents,,Ranolazine,,,,Angina pectoris,,,,, +14751648,204,,prevents,,Ranolazine,,,,myocardial ischemia,,,,, +14280230,205,,prevents,,Ranolazine,,,,atrial fibrillation,,,,, +17988674,206,,predisposes,,Ranolazine,,,,atrial fibrillation,,,,, +26862829,207,,related to,,Prednisolone,,,,multiple sclerosis,,,,, +26365803,208,,related to,,Prednisolone,,,,adrenocortical insufficiency,,,,, +26295217,209,,related to,,Prednisolone,,,,angioimmunoblastic T-cell lymphoma,,,,, +26194122,210,,related to,,Prednisolone,,,,synovitis,,,,, +25959730,211,,related to,,Prednisolone,,,,sarcoma,,,,, +25621708,212,,related to,,Prednisolone,,,,uveitis,,,,, +24523226,213,,related to,,Prednisolone,,,,glomerulonephritis,,,,, +23496152,214,,related to,,Prednisolone,,,,subacute thyroiditis,,,,, +22194722,215,,related to,,Prednisolone,,,,pulmonary eosinophilia,,,,, +21911849,216,,related to,,Prednisolone,,,,habitual spontaneous abortion,,,,, +20512112,217,,related to,,Prednisolone,,,,castration-resistant prostate carcinoma,,,,, +20312000,218,,related to,,Prednisolone,,,,chronic primary adrenal insufficiency,,,,, +20106181,219,,related to,,Prednisolone,,,,allergic bronchopulmonary aspergillosis,,,,, +19750187,220,,related to,,Prednisolone,,,,lymphoma,,,,, +17143213,221,,related to,,Prednisolone,,,,temporal arteritis,,,,, +16983852,222,,related to,,Prednisolone,,,,Hodgkins lymphoma,,,,, +16960031,223,,related to,,Prednisolone,,,,psoriatic arthritis,,,,, +16502712,224,,related to,,Prednisolone,,,,aplastic anemia,,,,, +16371065,225,,related to,,Prednisolone,,,,celiac disease,,,,, +16192798,226,,related to,,Prednisolone,,,,dermatomyositis,,,,, +16169223,227,,related to,,Prednisolone,,,,mucocutaneous lymph node syndrome,,,,, +16114172,228,,related to,,Prednisolone,,,,plasma cell myeloma,,,,, +14564343,229,,related to,,Prednisolone,,,,acute lymphoblastic leukemia,,,,, +13988965,230,,related to,,Prednisolone,,,,osteoarthritis,,,,, +13151963,231,,related to,,Prednisolone,,,,diffuse large B-cell lymphoma,,,,, +13151962,232,,related to,,Prednisolone,,,,follicular lymphoma,,,,, +12983495,233,,related to,,Prednisolone,,,,prostate cancer,,,,, +12510603,234,,related to,,Prednisolone,,,,membranous glomerulonephritis,,,,, +12496746,235,,related to,,Prednisolone,,,,neoplasm,,,,, +12428137,236,,related to,,Prednisolone,,,,croup,,,,, +12061894,237,,related to,,Prednisolone,,,,West syndrome,,,,, +11663099,238,,related to,,Prednisolone,,,,Crohn disease,,,,, +11638013,239,,related to,,Prednisolone,,,,eosinophilic granulomatosis with polyangiitis,,,,, +11213963,240,,related to,,Prednisolone,,,,leprosy,,,,, +11179224,241,,related to,,Prednisolone,,,,alcoholic hepatitis,,,,, +11142916,242,,related to,,Prednisolone,,,,lupus nephritis,,,,, +11037266,243,,related to,,Prednisolone,,,,granulomatosis with polyangiitis,,,,, +11013570,244,,related to,,Prednisolone,,,,leukemia,,,,, +10949449,245,,related to,,Prednisolone,,,,polymyalgia rheumatica,,,,, +10748640,246,,related to,,Prednisolone,,,,infertility disorder,,,,, +10744705,247,,related to,,Prednisolone,,,,"dermatitis, atopic",,,,, +10736101,248,,related to,,Prednisolone,,,,Graves disease,,,,, +10735679,249,,related to,,Prednisolone,,,,kidney disorder,,,,, +10715297,250,,related to,,Prednisolone,,,,keratitis,,,,, +10703266,251,,related to,,Prednisolone,,,,ulcerative colitis,,,,, +10687782,252,,related to,,Prednisolone,,,,hepatocellular carcinoma,,,,, +10623724,253,,related to,,Prednisolone,,,,hemolytic anemia,,,,, +10576837,254,,related to,,Prednisolone,,,,juvenile idiopathic arthritis,,,,, +10565620,255,,related to,,Prednisolone,,,,nephrotic syndrome,,,,, +10531966,256,,related to,,Prednisolone,,,,allergic disease,,,,, +10527508,257,,related to,,Prednisolone,,,,acute myeloid leukemia,,,,, +10503828,258,,related to,,Prednisolone,,,,seasonal allergic rhinitis,,,,, +10496403,259,,related to,,Prednisolone,,,,Inflammation,,,,, +10118116,260,,related to,,Prednisolone,,,,Prednisone,,,,, +9924521,261,,related to,,Prednisolone,,,,colitis,,,,, +9437304,262,,related to,,Prednisolone,,,,systemic lupus erythematosus,,,,, +9282196,263,,related to,,Prednisolone,,,,IgA glomerulonephritis,,,,, +9222009,264,,related to,,Prednisolone,,,,hypereosinophilic syndrome,,,,, +9216084,265,,related to,,Prednisolone,,,,non-Hodgkin lymphoma,,,,, +9208405,266,,related to,,Prednisolone,,,,Duchenne muscular dystrophy,,,,, +8405261,267,,related to,,Prednisolone,,,,asthma,,,,, +7844202,268,,related to,,Prednisolone,,,,chronic obstructive pulmonary disease,,,,, +7323744,269,,related to,,Prednisolone,,,,pemphigus,,,,, +7262473,270,,related to,,Prednisolone,,,,rheumatoid arthritis,,,,, +7206314,271,,related to,,Prednisolone,,,,pulmonary tuberculosis,,,,, +8856354,272,,related to,,Prednisolone,,,,Prednisone,,,,, +26879702,273,,has part,,Prednisolone,,,,acute lymphoblastic leukemia,,,,, +26670577,274,,has part,,Prednisolone,,,,plasma cell myeloma,,,,, +18935086,275,,coexists with,,Prednisolone,,,,Prednisone,,,,, +9296680,276,,derives from,,Prednisolone,,,,Prednisone,,,,, +26415442,277,,derives from,,Prednisolone,,,,Prednisone,,,,, +14808035,278,,physically interacts with,,Prednisolone,,,,Prednisone,,,,, +9296682,279,,physically interacts with,,Prednisolone,,,,Prednisone,,,,, +27055840,280,,causes,,Prednisolone,,,,glaucoma,,,,, +26677891,281,,causes,,Prednisolone,,,,uveitis,,,,, +25953223,282,,causes,,Prednisolone,,,,kidney disorder,,,,, +21556285,283,,causes,,Prednisolone,,,,allergic disease,,,,, +21293782,284,,causes,,Prednisolone,,,,adrenocortical insufficiency,,,,, +20789636,285,,causes,,Prednisolone,,,,ulcerative colitis,,,,, +17230021,286,,causes,,Prednisolone,,,,Headache,,,,, +16304261,287,,causes,,Prednisolone,,,,nephrotic syndrome,,,,, +15365269,288,,causes,,Prednisolone,,,,infertility disorder,,,,, +14373522,289,,causes,,Prednisolone,,,,exfoliative dermatitis,,,,, +10735861,290,,causes,,Prednisolone,,,,contact dermatitis,,,,, +10545904,291,,causes,,Prednisolone,,,,pulmonary tuberculosis,,,,, +10519611,292,,causes,,Prednisolone,,,,colitis,,,,, +9464043,293,,causes,,Prednisolone,,,,cataract,,,,, +8757881,294,,causes,,Prednisolone,,,,systemic lupus erythematosus,,,,, +27658451,295,,affects,,Prednisolone,,,,uveitis,,,,, +27410586,296,,affects,,Prednisolone,,,,castration-resistant prostate carcinoma,,,,, +27323391,297,,affects,,Prednisolone,,,,focal segmental glomerulosclerosis,,,,, +27042309,298,,affects,,Prednisolone,,,,pulmonary eosinophilia,,,,, +25790510,299,,affects,,Prednisolone,,,,allergic disease,,,,, +25165576,300,,affects,,Prednisolone,,,,glomerulonephritis,,,,, +24270725,301,,affects,,Prednisolone,,,,dermatomyositis,,,,, +22922261,302,,affects,,Prednisolone,,,,allergic bronchopulmonary aspergillosis,,,,, +19824794,303,,affects,,Prednisolone,,,,colitis,,,,, +19409335,304,,affects,,Prednisolone,,,,sarcoidosis,,,,, +18736907,305,,affects,,Prednisolone,,,,asthma,,,,, +17668631,306,,affects,,Prednisolone,,,,Prednisone,,,,, +15888410,307,,affects,,Prednisolone,,,,rheumatoid arthritis,,,,, +13564625,308,,affects,,Prednisolone,,,,asthma,,,,, +13234063,309,,affects,,Prednisolone,,,,pericarditis,,,,, +13029310,310,,affects,,Prednisolone,,,,chronic obstructive pulmonary disease,,,,, +12949384,311,,affects,,Prednisolone,,,,hypereosinophilic syndrome,,,,, +12057849,312,,affects,,Prednisolone,,,,Crohn disease,,,,, +11166436,313,,affects,,Prednisolone,,,,Headache,,,,, +11074135,314,,affects,,Prednisolone,,,,lymphoma,,,,, +10651502,315,,affects,,Prednisolone,,,,kidney disorder,,,,, +10649036,316,,affects,,Prednisolone,,,,chorioretinitis,,,,, +10555139,317,,affects,,Prednisolone,,,,peptic ulcer disease,,,,, +10183156,318,,affects,,Prednisolone,,,,ulcerative colitis,,,,, +9735520,319,,affects,,Prednisolone,,,,Inflammation,,,,, +9361682,320,,affects,,Prednisolone,,,,osteoarthritis,,,,, +8533593,321,,affects,,Prednisolone,,,,neoplasm,,,,, +7800426,322,,affects,,Prednisolone,,,,acute lymphoblastic leukemia,,,,, +7395227,323,,affects,,Prednisolone,,,,systemic lupus erythematosus,,,,, +21722189,324,,affects,,Prednisolone,,,,Prednisone,,,,, +9655099,325,,has input,,Prednisolone,,,,Prednisone,,,,, +27206106,326,,disrupts,,Prednisolone,,,,uveitis,,,,, +26515767,327,,disrupts,,Prednisolone,,,,neoplasm,,,,, +26379811,328,,disrupts,,Prednisolone,,,,contact dermatitis,,,,, +25763558,329,,disrupts,,Prednisolone,,,,pneumonia,,,,, +25233555,330,,disrupts,,Prednisolone,,,,allergic disease,,,,, +14331279,331,,disrupts,,Prednisolone,,,,hypereosinophilic syndrome,,,,, +10594561,332,,disrupts,,Prednisolone,,,,asthma,,,,, +8854473,333,,disrupts,,Prednisolone,,,,Inflammation,,,,, +27646185,334,,prevents,,Prednisolone,,,,allergic disease,,,,, +26227245,335,,prevents,,Prednisolone,,,,synovitis,,,,, +19453072,336,,prevents,,Prednisolone,,,,hypereosinophilic syndrome,,,,, +16706850,337,,prevents,,Prednisolone,,,,neoplasm,,,,, +15809068,338,,prevents,,Prednisolone,,,,colitis,,,,, +11858005,339,,prevents,,Prednisolone,,,,asthma,,,,, +10983909,340,,prevents,,Prednisolone,,,,leprosy,,,,, +10240036,341,,prevents,,Prednisolone,,,,Inflammation,,,,, +18452194,342,,exacerbates,,Prednisolone,,,,ulcerative colitis,,,,, +25753407,343,,predisposes,,Prednisolone,,,,neoplasm,,,,, +16546227,344,,predisposes,,Prednisolone,,,,pneumonia,,,,, +27027571,345,,related to,,Hydrocortisone,,,,HIV infectious disease,,,,, +25927636,346,,related to,,Hydrocortisone,,,,cardiac arrest,,,,, +25797574,347,,related to,,Hydrocortisone,,,,lymphoma,,,,, +25131277,348,,related to,,Hydrocortisone,,,,Crohn disease,,,,, +19793698,349,,related to,,Hydrocortisone,,,,alcohol abuse,,,,, +19531872,350,,related to,,Hydrocortisone,,,,atrial fibrillation,,,,, +18705900,351,,related to,,Hydrocortisone,,,,phobic disorder,,,,, +15155784,352,,related to,,Hydrocortisone,,,,psoriasis,,,,, +14891361,353,,related to,,Hydrocortisone,,,,"dermatitis, atopic",,,,, +14483328,354,,related to,,Hydrocortisone,,,,bronchopulmonary dysplasia,,,,, +14450267,355,,related to,,Hydrocortisone,,,,adrenal cortex neoplasm,,,,, +14387016,356,,related to,,Hydrocortisone,,,,cirrhosis of liver,,,,, +14360687,357,,related to,,Hydrocortisone,,,,dermatitis,,,,, +13844584,358,,related to,,Hydrocortisone,,,,acute myeloid leukemia,,,,, +13213365,359,,related to,,Hydrocortisone,,,,chronic primary adrenal insufficiency,,,,, +12756660,360,,related to,,Hydrocortisone,,,,borderline personality disorder,,,,, +12576998,361,,related to,,Hydrocortisone,,,,Hypoxemia,,,,, +11888652,362,,related to,,Hydrocortisone,,,,congenital adrenal hyperplasia,,,,, +11866289,363,,related to,,Hydrocortisone,,,,nicotine dependence,,,,, +11530989,364,,related to,,Hydrocortisone,,,,pneumonia,,,,, +11442939,365,,related to,,Hydrocortisone,,,,prostate cancer,,,,, +11089023,366,,related to,,Hydrocortisone,,,,pancreatitis,,,,, +10649902,367,,related to,,Hydrocortisone,,,,myocardial infarction,,,,, +10522181,368,,related to,,Hydrocortisone,,,,osteoarthritis,,,,, +10521296,369,,related to,,Hydrocortisone,,,,eye disorder,,,,, +10518203,370,,related to,,Hydrocortisone,,,,otitis externa,,,,, +10484611,371,,related to,,Hydrocortisone,,,,ulcerative colitis,,,,, +9718673,372,,related to,,Hydrocortisone,,,,atopic eczema,,,,, +9492934,373,,related to,,Hydrocortisone,,,,opiate dependence,,,,, +9238280,374,,related to,,Hydrocortisone,,,,Sepsis,,,,, +9235597,375,,related to,,Hydrocortisone,,,,type 1 diabetes mellitus,,,,, +8977987,376,,related to,,Hydrocortisone,,,,injury,,,,, +8778414,377,,related to,,Hydrocortisone,,,,Inflammation,,,,, +8763179,378,,related to,,Hydrocortisone,,,,toxic shock syndrome,,,,, +8625521,379,,related to,,Hydrocortisone,,,,dissociative amnesia,,,,, +8615164,380,,related to,,Hydrocortisone,,,,asthma,,,,, +8570630,381,,related to,,Hydrocortisone,,,,fibromyalgia,,,,, +8017438,382,,related to,,Hydrocortisone,,,,Insulin resistance,,,,, +7919367,383,,related to,,Hydrocortisone,,,,adrenocortical insufficiency,,,,, +7573954,384,,related to,,Hydrocortisone,,,,neoplasm,,,,, +7182905,385,,related to,,Hydrocortisone,,,,obesity disorder,,,,, +24445107,386,,related to,,Hydrocortisone,,,,Inflammation,,,,, +24030854,387,,related to,,Hydrocortisone,,,,Hypoxemia,,,,, +12533519,388,,related to,,Hydrocortisone,,,,Insulin resistance,,,,, +27747116,389,,causes,,Hydrocortisone,,,,toxic shock syndrome,,,,, +27747115,390,,causes,,Hydrocortisone,,,,Sepsis,,,,, +27073884,391,,causes,,Hydrocortisone,,,,atopic eczema,,,,, +25383174,392,,causes,,Hydrocortisone,,,,fibromyalgia,,,,, +25205462,393,,causes,,Hydrocortisone,,,,hypotensive disorder,,,,, +20591759,394,,causes,,Hydrocortisone,,,,Hypoxemia,,,,, +18446972,395,,causes,,Hydrocortisone,,,,congenital adrenal hyperplasia,,,,, +18240145,396,,causes,,Hydrocortisone,,,,injury,,,,, +17359303,397,,causes,,Hydrocortisone,,,,influenza,,,,, +13585273,398,,causes,,Hydrocortisone,,,,"dermatitis, atopic",,,,, +12645476,399,,causes,,Hydrocortisone,,,,obesity disorder,,,,, +10068843,400,,causes,,Hydrocortisone,,,,Inflammation,,,,, +9850315,401,,causes,,Hydrocortisone,,,,dissociative amnesia,,,,, +9318796,402,,causes,,Hydrocortisone,,,,adrenocortical insufficiency,,,,, +9145908,403,,causes,,Hydrocortisone,,,,otitis externa,,,,, +8699464,404,,causes,,Hydrocortisone,,,,adrenal cortex neoplasm,,,,, +8657746,405,,causes,,Hydrocortisone,,,,neoplasm,,,,, +7929803,406,,causes,,Hydrocortisone,,,,Insulin resistance,,,,, +7432490,407,,causes,,Hydrocortisone,,,,pancreatitis,,,,, +26997315,408,,affects,,Hydrocortisone,,,,congenital adrenal hyperplasia,,,,, +26940919,409,,affects,,Hydrocortisone,,,,cardiac arrest,,,,, +26840479,410,,affects,,Hydrocortisone,,,,myocardial infarction,,,,, +24701128,411,,affects,,Hydrocortisone,,,,Sepsis,,,,, +21274202,412,,affects,,Hydrocortisone,,,,osteoarthritis,,,,, +20701310,413,,affects,,Hydrocortisone,,,,psoriasis,,,,, +20336537,414,,affects,,Hydrocortisone,,,,dermatitis,,,,, +20137862,415,,affects,,Hydrocortisone,,,,fibromyalgia,,,,, +19555227,416,,affects,,Hydrocortisone,,,,pneumonia,,,,, +19531871,417,,affects,,Hydrocortisone,,,,atrial fibrillation,,,,, +18495054,418,,affects,,Hydrocortisone,,,,lymphoma,,,,, +18495053,419,,affects,,Hydrocortisone,,,,leukemia,,,,, +18310128,420,,affects,,Hydrocortisone,,,,toxic shock syndrome,,,,, +17910566,421,,affects,,Hydrocortisone,,,,atopic eczema,,,,, +15925719,422,,affects,,Hydrocortisone,,,,Inflammation,,,,, +14970164,423,,affects,,Hydrocortisone,,,,Insulin resistance,,,,, +14804311,424,,affects,,Hydrocortisone,,,,injury,,,,, +14533429,425,,affects,,Hydrocortisone,,,,hypotensive disorder,,,,, +13999195,426,,affects,,Hydrocortisone,,,,congenital adrenal hyperplasia,,,,, +13347553,427,,affects,,Hydrocortisone,,,,asthma,,,,, +13180935,428,,affects,,Hydrocortisone,,,,hypotensive disorder,,,,, +11695335,429,,affects,,Hydrocortisone,,,,Hypoxemia,,,,, +11304252,430,,affects,,Hydrocortisone,,,,obesity disorder,,,,, +10523644,431,,affects,,Hydrocortisone,,,,injury,,,,, +10431364,432,,affects,,Hydrocortisone,,,,Inflammation,,,,, +10074536,433,,affects,,Hydrocortisone,,,,HIV infectious disease,,,,, +9872405,434,,affects,,Hydrocortisone,,,,toxic shock syndrome,,,,, +9610203,435,,affects,,Hydrocortisone,,,,neoplasm,,,,, +9120606,436,,affects,,Hydrocortisone,,,,asthma,,,,, +8017440,437,,affects,,Hydrocortisone,,,,obesity disorder,,,,, +7974249,438,,affects,,Hydrocortisone,,,,Insulin resistance,,,,, +7366981,439,,affects,,Hydrocortisone,,,,Hypoxemia,,,,, +7266667,440,,affects,,Hydrocortisone,,,,dissociative amnesia,,,,, +27426083,441,,produces,,Hydrocortisone,,,,HIV infectious disease,,,,, +24427531,442,,produces,,Hydrocortisone,,,,cirrhosis of liver,,,,, +23738730,443,,produces,,Hydrocortisone,,,,congenital adrenal hyperplasia,,,,, +20514012,444,,produces,,Hydrocortisone,,,,"dermatitis, atopic",,,,, +18924640,445,,produces,,Hydrocortisone,,,,Inflammation,,,,, +16473285,446,,produces,,Hydrocortisone,,,,type 1 diabetes mellitus,,,,, +15760263,447,,produces,,Hydrocortisone,,,,toxic shock syndrome,,,,, +15330155,448,,produces,,Hydrocortisone,,,,chronic primary adrenal insufficiency,,,,, +14100936,449,,produces,,Hydrocortisone,,,,Insulin resistance,,,,, +13891079,450,,produces,,Hydrocortisone,,,,obesity disorder,,,,, +13796050,451,,produces,,Hydrocortisone,,,,adrenal cortex neoplasm,,,,, +13783969,452,,produces,,Hydrocortisone,,,,adrenocortical insufficiency,,,,, +13669597,453,,produces,,Hydrocortisone,,,,asthma,,,,, +12147996,454,,produces,,Hydrocortisone,,,,Sepsis,,,,, +11989948,455,,produces,,Hydrocortisone,,,,Hypoxemia,,,,, +11730055,456,,produces,,Hydrocortisone,,,,pneumonia,,,,, +8328567,457,,produces,,Hydrocortisone,,,,prostate cancer,,,,, +8077250,458,,produces,,Hydrocortisone,,,,neoplasm,,,,, +27711985,459,,disrupts,,Hydrocortisone,,,,adrenocortical insufficiency,,,,, +26428860,460,,disrupts,,Hydrocortisone,,,,leukemia,,,,, +26389045,461,,disrupts,,Hydrocortisone,,,,neoplasm,,,,, +26128287,462,,disrupts,,Hydrocortisone,,,,melanoma,,,,, +21020907,463,,disrupts,,Hydrocortisone,,,,pneumonia,,,,, +15895489,464,,disrupts,,Hydrocortisone,,,,obesity disorder,,,,, +15750557,465,,disrupts,,Hydrocortisone,,,,injury,,,,, +8865955,466,,disrupts,,Hydrocortisone,,,,Inflammation,,,,, +26205555,467,,prevents,,Hydrocortisone,,,,neoplasm,,,,, +19342068,468,,prevents,,Hydrocortisone,,,,obesity disorder,,,,, +19245686,469,,prevents,,Hydrocortisone,,,,toxic shock syndrome,,,,, +18758297,470,,prevents,,Hydrocortisone,,,,injury,,,,, +17956690,471,,prevents,,Hydrocortisone,,,,Sepsis,,,,, +16963888,472,,prevents,,Hydrocortisone,,,,adrenocortical insufficiency,,,,, +15550113,473,,prevents,,Hydrocortisone,,,,Inflammation,,,,, +15540854,474,,prevents,,Hydrocortisone,,,,pneumonia,,,,, +14020540,475,,prevents,,Hydrocortisone,,,,bronchopulmonary dysplasia,,,,, +13075196,476,,prevents,,Hydrocortisone,,,,atrial fibrillation,,,,, +12187318,477,,prevents,,Hydrocortisone,,,,Insulin resistance,,,,, +14643692,478,,exacerbates,,Hydrocortisone,,,,Sepsis,,,,, +8122784,479,,exacerbates,,Hydrocortisone,,,,obesity disorder,,,,, +25411585,480,,predisposes,,Hydrocortisone,,,,atrial fibrillation,,,,, +19755964,481,,predisposes,,Hydrocortisone,,,,Sepsis,,,,, +13712588,482,,predisposes,,Hydrocortisone,,,,injury,,,,, +12555774,483,,predisposes,,Hydrocortisone,,,,toxic shock syndrome,,,,, +11782928,484,,predisposes,,Hydrocortisone,,,,Inflammation,,,,, +10520517,485,,predisposes,,Hydrocortisone,,,,obesity disorder,,,,, +8615556,486,,predisposes,,Hydrocortisone,,,,dissociative amnesia,,,,, +8552834,487,,predisposes,,Hydrocortisone,,,,asthma,,,,, +8002300,488,,predisposes,,Hydrocortisone,,,,Insulin resistance,,,,, +7960726,489,,predisposes,,Hydrocortisone,,,,pneumonia,,,,, +27228384,490,,related to,,Methylprednisolone,,,,Crohn disease,,,,, +26974005,491,,related to,,Methylprednisolone,,,,hematopoietic and lymphoid system neoplasm,,,,, +26513818,492,,related to,,Methylprednisolone,,,,B-cell chronic lymphocytic leukemia,,,,, +26050805,493,,related to,,Methylprednisolone,,,,ankylosing spondylitis,,,,, +25845844,494,,related to,,Methylprednisolone,,,,breast neoplasm,,,,, +25642837,495,,related to,,Methylprednisolone,,,,dermatomyositis,,,,, +25328503,496,,related to,,Methylprednisolone,,,,Meniere disease,,,,, +24759961,497,,related to,,Methylprednisolone,,,,non-Hodgkin lymphoma,,,,, +24691450,498,,related to,,Methylprednisolone,,,,plantar fasciitis,,,,, +24586108,499,,related to,,Methylprednisolone,,,,alcoholic hepatitis,,,,, +24559507,500,,related to,,Methylprednisolone,,,,respiratory system disorder,,,,, +23573980,1,,related to,,Methylprednisolone,,,,pneumonia,,,,, +23514846,2,,related to,,Methylprednisolone,,,,carpal tunnel syndrome,,,,, +23364897,3,,related to,,Methylprednisolone,,,,West syndrome,,,,, +22495910,4,,related to,,Methylprednisolone,,,,myocarditis,,,,, +22175056,5,,related to,,Methylprednisolone,,,,myopathy,,,,, +20879022,6,,related to,,Methylprednisolone,,,,Pain,,,,, +20342058,7,,related to,,Methylprednisolone,,,,chronic progressive multiple sclerosis,,,,, +20290784,8,,related to,,Methylprednisolone,,,,membranous glomerulonephritis,,,,, +20286711,9,,related to,,Methylprednisolone,,,,neuromyelitis optica,,,,, +19340184,10,,related to,,Methylprednisolone,,,,chronic obstructive pulmonary disease,,,,, +18938435,11,,related to,,Methylprednisolone,,,,graft versus host disease,,,,, +17333962,12,,related to,,Methylprednisolone,,,,Inflammation,,,,, +17288506,13,,related to,,Methylprednisolone,,,,autoimmune thrombocytopenic purpura,,,,, +15936572,14,,related to,,Methylprednisolone,,,,endocrine exophthalmos,,,,, +15072844,15,,related to,,Methylprednisolone,,,,Edema,,,,, +14876749,16,,related to,,Methylprednisolone,,,,osteoarthritis,,,,, +14399082,17,,related to,,Methylprednisolone,,,,aplastic anemia,,,,, +14398237,18,,related to,,Methylprednisolone,,,,IgA glomerulonephritis,,,,, +14278238,19,,related to,,Methylprednisolone,,,,"dermatitis, atopic",,,,, +14166179,20,,related to,,Methylprednisolone,,,,cardiac arrest,,,,, +12755316,21,,related to,,Methylprednisolone,,,,plasma cell myeloma,,,,, +12183687,22,,related to,,Methylprednisolone,,,,acute lymphoblastic leukemia,,,,, +11720471,23,,related to,,Methylprednisolone,,,,systemic lupus erythematosus,,,,, +10812685,24,,related to,,Methylprednisolone,,,,immunoglobulin a vasculitis,,,,, +10763477,25,,related to,,Methylprednisolone,,,,ulcerative colitis,,,,, +10558884,26,,related to,,Methylprednisolone,,,,lupus nephritis,,,,, +10130342,27,,related to,,Methylprednisolone,,,,adult acute respiratory distress syndrome,,,,, +9229208,28,,related to,,Methylprednisolone,,,,vestibular neuronitis,,,,, +9003326,29,,related to,,Methylprednisolone,,,,systemic sclerosis,,,,, +8447481,30,,related to,,Methylprednisolone,,,,rheumatoid arthritis,,,,, +8282330,31,,related to,,Methylprednisolone,,,,spinal cord injury,,,,, +7944646,32,,related to,,Methylprednisolone,,,,myasthenia gravis,,,,, +7668599,33,,related to,,Methylprednisolone,,,,multiple sclerosis,,,,, +7443745,34,,related to,,Methylprednisolone,,,,asthma,,,,, +24973247,35,,causes,,Methylprednisolone,,,,lupus nephritis,,,,, +24161886,36,,causes,,Methylprednisolone,,,,Edema,,,,, +18534953,37,,causes,,Methylprednisolone,,,,Inflammation,,,,, +18260665,38,,causes,,Methylprednisolone,,,,neoplasm,,,,, +17307095,39,,causes,,Methylprednisolone,,,,pneumonia,,,,, +15906641,40,,causes,,Methylprednisolone,,,,Pain,,,,, +13166073,41,,causes,,Methylprednisolone,,,,thrombocytopenia,,,,, +12672767,42,,causes,,Methylprednisolone,,,,drug-induced liver injury,,,,, +8525599,43,,causes,,Methylprednisolone,,,,myopathy,,,,, +27357949,44,,affects,,Methylprednisolone,,,,neoplasm,,,,, +24420470,45,,affects,,Methylprednisolone,,,,Inflammation,,,,, +23472756,46,,affects,,Methylprednisolone,,,,Inflammation,,,,, +20530617,47,,affects,,Methylprednisolone,,,,systemic sclerosis,,,,, +20254789,48,,affects,,Methylprednisolone,,,,adult acute respiratory distress syndrome,,,,, +17649050,49,,affects,,Methylprednisolone,,,,optic nerve disorder,,,,, +16634377,50,,affects,,Methylprednisolone,,,,myasthenia gravis,,,,, +16277488,51,,affects,,Methylprednisolone,,,,neuromyelitis optica,,,,, +15906642,52,,affects,,Methylprednisolone,,,,Pain,,,,, +15610554,53,,affects,,Methylprednisolone,,,,rheumatoid arthritis,,,,, +15186368,54,,affects,,Methylprednisolone,,,,graft versus host disease,,,,, +14891106,55,,affects,,Methylprednisolone,,,,kidney disorder,,,,, +11819955,56,,affects,,Methylprednisolone,,,,spinal cord injury,,,,, +10845505,57,,affects,,Methylprednisolone,,,,Pain,,,,, +10048898,58,,affects,,Methylprednisolone,,,,ulcerative colitis,,,,, +9646753,59,,affects,,Methylprednisolone,,,,multiple sclerosis,,,,, +9346353,60,,affects,,Methylprednisolone,,,,chronic obstructive pulmonary disease,,,,, +9107378,61,,affects,,Methylprednisolone,,,,Edema,,,,, +8596544,62,,affects,,Methylprednisolone,,,,asthma,,,,, +8330909,63,,affects,,Methylprednisolone,,,,systemic lupus erythematosus,,,,, +19744632,64,,disrupts,,Methylprednisolone,,,,Edema,,,,, +18407557,65,,disrupts,,Methylprednisolone,,,,thrombocytopenia,,,,, +11106658,66,,disrupts,,Methylprednisolone,,,,Pain,,,,, +8640603,67,,disrupts,,Methylprednisolone,,,,Inflammation,,,,, +23934495,68,,prevents,,Methylprednisolone,,,,Cognitive impairment,,,,, +20014108,69,,prevents,,Methylprednisolone,,,,rheumatoid arthritis,,,,, +18266414,70,,prevents,,Methylprednisolone,,,,Abdominal pain,,,,, +14967074,71,,prevents,,Methylprednisolone,,,,asthma,,,,, +9744990,72,,prevents,,Methylprednisolone,,,,ovarian hyperstimulation syndrome,,,,, +8345063,73,,prevents,,Methylprednisolone,,,,Pain,,,,, +8291272,74,,prevents,,Methylprednisolone,,,,graft versus host disease,,,,, +7980138,75,,prevents,,Methylprednisolone,,,,spinal cord injury,,,,, +7414405,76,,prevents,,Methylprednisolone,,,,Edema,,,,, +18106042,77,,predisposes,,Methylprednisolone,,,,pneumonia,,,,, +9645180,78,,predisposes,,Methylprednisolone,,,,Inflammation,,,,, +12905337,79,,related to,,Cefotaxime,,,,Sepsis,,,,, +24475300,80,,affects,,Cefotaxime,,,,bacterial infectious disease,,,,, +23922029,81,,affects,,Cefotaxime,,,,Sepsis,,,,, +18672205,82,,affects,,Cefotaxime,,,,peritonitis,,,,, +15853591,83,,prevents,,Cefotaxime,,,,Sepsis,,,,, +19081412,84,,prevents,,Ceftriaxone,,,,bacterial infectious disease,,,,, +25827448,85,,related to,,Gefarnate,,,,gastric ulcer,,,,, +24296137,86,,related to,,Gefarnate,,,,duodenal ulcer,,,,, +25993651,87,,disrupts,,Gefarnate,,,,gastric ulcer,,,,, +17758516,88,,related to,,Neobiotic,,,,Inflammation,,,,, +10690423,89,,related to,,Neobiotic,,,,burn,,,,, +20263460,90,,affects,,Neobiotic,,,,neoplasm,,,,, +19744068,91,,affects,,Neobiotic,,,,Inflammation,,,,, +24669492,92,,disrupts,,Neobiotic,,,,bacterial infectious disease,,,,, +17119153,93,,disrupts,,Neobiotic,,,,neoplasm,,,,, +26428369,94,,prevents,,Neobiotic,,,,bacterial infectious disease,,,,, +25579460,95,,related to,,BLINATUMOMAB,,,,Precursor B-Cell Lymphoblastic Leukemia-Lymphoma,,,,, +22474123,96,,related to,,BLINATUMOMAB,,,,hematopoietic and lymphoid system neoplasm,,,,, +21947892,97,,related to,,BLINATUMOMAB,,,,acute lymphoblastic leukemia,,,,, +27155094,98,,related to,,Ciprofloxacin,,,,endophthalmitis,,,,, +16836665,99,,related to,,Ciprofloxacin,,,,Crohn disease,,,,, +19572117,100,,related to,,Ciprofloxacin,,,,DNA Gyrase,,,,, diff --git a/src/get_result.py b/src/get_result.py index 4907b83..46b29dc 100644 --- a/src/get_result.py +++ b/src/get_result.py @@ -25,7 +25,7 @@ def get_result(model_info, prompt, model_type): model = model_info full_prompt = prompt prompt = full_prompt - prompt_template=f'''SYSTEM: You are scientist. Read carefully and answer only yes or no. + prompt_template=f'''SYSTEM: You are computational biologist. Read carefully and please start your answer with 'Yes' or 'No' followed by a justification of why you chose that answer. USER: {prompt} diff --git a/util/chembl/convert.py b/util/chembl/convert.py index f9b2674..e3c0be4 100644 --- a/util/chembl/convert.py +++ b/util/chembl/convert.py @@ -20,7 +20,8 @@ def create_csvs(json_path: str, name: str): "OBJECT_CUI", "OBJECT_NAME", "OBJECT_SEMTYPE", "OBJECT_NOVELTY", "Column", "Column", "Column"] triple_records = [] - sentence_id = 1000 + sentence_id = 0 + n=100 for item in data: segments = item['p3']['segments'][0] @@ -37,14 +38,15 @@ def create_csvs(json_path: str, name: str): print(sentence) sentence_id = sentence_id+1 predicate_id = predicate_data['id'] + labeled_records.append({ "Predicate ID": predicate_id, "Triple": f"{subject_name} {predicate} {object_name}", - "Sentence ID": sentence_id, + "Sentence ID": sentence_id+n, "Sentence": sentence, "Question": f"Is the triple \"{subject_name} {predicate} {object_name}\" supported by the sentence: \"{sentence}\"?", - "Label": True, + "Label": False, "Reference": None }) sentence_records.append({ @@ -62,7 +64,7 @@ def create_csvs(json_path: str, name: str): triple_records.append({ "PREDICATION_ID": predicate_id, - "SENTENCE_ID": sentence_id, + "SENTENCE_ID": sentence_id+n, "PMID": None, "PREDICATE": predicate, "SUBJECT_CUI": None, @@ -77,6 +79,8 @@ def create_csvs(json_path: str, name: str): "Column": None, "Column": None }) + if sentence_id==400: + n=-400 labeled_records_df=pd.DataFrame(labeled_records, columns=labeled_columns) sentence_df = pd.DataFrame(sentence_records, columns=sentence_columns) triple_df = pd.DataFrame(triple_records, columns=triple_columns) @@ -84,6 +88,6 @@ def create_csvs(json_path: str, name: str): labeled_records_df.to_csv(f"{name}_labeled_records.csv", index=False) sentence_df.to_csv(f"{name}_sentence_data.csv", index=False) triple_df.to_csv(f"{name}_triple_data.csv", index=False) + - -create_csvs('json/neo4j.json', 'true') +create_csvs('json/neo4j_false.json', 'false')