From eef4a82aa05389a658e98d475114d185427e268e Mon Sep 17 00:00:00 2001 From: Maksym Date: Tue, 27 Feb 2024 21:46:59 -0500 Subject: [PATCH] LLMFactCheck --- data/1.csv | 3926 ++++++++++++++++++++++++++++++++++++++-------------- 1 file changed, 2897 insertions(+), 1029 deletions(-) diff --git a/data/1.csv b/data/1.csv index c9b0c04..cd43e3e 100644 --- a/data/1.csv +++ b/data/1.csv @@ -1,1030 +1,2898 @@ Predicate ID,Triple,Sentence ID,Sentence,Is Correct,Question,Answer -24413653,Fenbendazole treats helminthiasis,1001,"This study investigated worm control practices by free-range egg farmers and the efficacy of the commercial anthelmintics levamisole (LEV), piperazine (PIP), flubendazole (FLBZ) and fenbendazole (FBZ) against gastrointestinal nematodes on two free-range layer farms in Australia.",True,"Is the triple 'Fenbendazole treats helminthiasis' supported by the sentence: 'This study investigated worm control practices by free-range egg farmers and the efficacy of the commercial anthelmintics levamisole (LEV), piperazine (PIP), flubendazole (FLBZ) and fenbendazole (FBZ) against gastrointestinal nematodes on two free-range layer farms in Australia.'?","Yes, the sentence does indirectly support the statement that Fenbendazole (FBZ) treats helminthiasis (a condition also known as helminth infection, which is another term for gastrointestinal nematodes). The study mentions Fenbendazole as one of the commercial anthelmintics (deworming agents) being investigated for its efficacy against gastrointestinal nematodes on two free-range layer farms in Australia. This indicates that Fenbendazole is used to treat infections caused by these parasitic worms, which aligns with the statement that Fenbendazole is used to treat helminthiasis." -9783282,Thiabendazole treats helminthiasis,1002,[The treatment of helminthiasis with thiabendazole].,True,Is the triple 'Thiabendazole treats helminthiasis' supported by the sentence: '[The treatment of helminthiasis with thiabendazole].'?,"Yes, the sentence ""The treatment of helminthiasis with thiabendazole"" does indirectly support the statement ""Thiabendazole treats helminthiasis"". This is because if thiabendazole is used in the treatment of helminthiasis, it implies that thiabendazole has some effect on the condition, which is what 'treats' means in this context. However, it does not directly support it because it does not explicitly state that thiabendazole is effective against helminthiasis, but only implies it." -22678969,Albendazole treats Infection,1003,The control of STH infections is based on preventive chemotherapy using either albendazole or mebendazole.,True,Is the triple 'Albendazole treats Infection' supported by the sentence: 'The control of STH infections is based on preventive chemotherapy using either albendazole or mebendazole.'?,"Yes, the sentence does indirectly support the statement that Albendazole treats infection. The sentence states that the control of STH (Soil Transmitted Helminths) infections is based on preventive chemotherapy using either Albendazole or Mebendazole. This implies that these drugs, including Albendazole, are used to treat infections caused by STH, thus supporting the claim that Albendazole treats infection." -10750815,Albendazole treats onchocerciasis,1004,"A double-blind clinical trial was conducted in Monagas State, Venezuela to assess the tolerance and efficacy of albendazole in the therapy of Onchocerca volvulus infection.",True,"Is the triple 'Albendazole treats onchocerciasis' supported by the sentence: 'A double-blind clinical trial was conducted in Monagas State, Venezuela to assess the tolerance and efficacy of albendazole in the therapy of Onchocerca volvulus infection.'?","Yes, this statement does indirectly support the claim that Albendazole treats Onchocerciasis (also known as River Blindness, which is caused by the parasitic worm Onchocerca volvulus). The sentence mentions a double-blind clinical trial conducted to assess the tolerance and efficacy of Albendazole in the therapy of Onchocerca volvulus infection, which implies that Albendazole was used as a treatment for Onchocerca volvulus infection, thus supporting its role in treating Onchocerciasis." -10114050,Albendazole treats toxocariasis,1005,"The treatment of cutaneous larva migrans and Toxocara infection relies on antihelminthic agents such as thiabendazole, albendazole and ivermectin.",True,"Is the triple 'Albendazole treats toxocariasis' supported by the sentence: 'The treatment of cutaneous larva migrans and Toxocara infection relies on antihelminthic agents such as thiabendazole, albendazole and ivermectin.'?","Yes, this statement does indirectly support the claim that Albendazole can treat Toxocariasis, which is an infection caused by Toxocara parasites, because it lists Albendazole as one of the antihelminthic agents used in treating Toxocara infections, along with Thiabendazole and Ivermectin. The statement also mentions Cutaneous Larva Migrans, another condition associated with Toxocara infections, which further strengthens this indirect support for Albendazole as an effective treatment for Toxocariasis." -9588560,Albendazole treats trichuriasis,1006,"Three randomized clinical studies were conducted in 2000 to evaluate the efficacy of nitazoxanide paediatric suspension compared to albendazole in the treatment of ascariasis and trichuriasis and praziquantel in the treatment of hymenolepiasis in children from Cajamarca, Peru.",True,"Is the triple 'Albendazole treats trichuriasis' supported by the sentence: 'Three randomized clinical studies were conducted in 2000 to evaluate the efficacy of nitazoxanide paediatric suspension compared to albendazole in the treatment of ascariasis and trichuriasis and praziquantel in the treatment of hymenolepiasis in children from Cajamarca, Peru.'?","Yes, this statement does indirectly support the claim that albendazole treats trichuriasis (a type of worm infection also known as whipworm infection). The sentence mentions that three randomized clinical studies were conducted in 2000 to evaluate the efficacy of albendazole in treating trichuriasis in children from Cajamarca, Peru. Therefore, it suggests that albendazole was used as a treatment option for trichuriasis, which is what the statement claims. However, it does not directly support the specific claim about albendazole treating trichuriasis, as it does not mention anything about albendazole being effective at treating this condition, only that it was used in these studies to treat it." -9492446,Albendazole treats filariasis,1007,"Today, the only way is the prophylactic control of Onchocerca vovulus infections and treating lymphatic filariosis with ivermectin, diethylcarbamacine, ivermectin/diethylcarbamazine. or ivermectin/albendazole combinations.",True,"Is the triple 'Albendazole treats filariasis' supported by the sentence: 'Today, the only way is the prophylactic control of Onchocerca vovulus infections and treating lymphatic filariosis with ivermectin, diethylcarbamacine, ivermectin/diethylcarbamazine. or ivermectin/albendazole combinations.'?","Yes, this statement does indirectly support the claim that Albendazole can be used to treat filariasis, specifically in combination with ivermectin according to the provided sentence. It mentions ivermectin/albendazole combinations as an option for treating lymphatic filariosis, which is another term for filariasis, thus supporting the claim indirectly." -8712067,Albendazole treats helminthiasis,1008,The study population was assessed for helminthic infection and those found to be positive were randomly assigned to either an albendazole treatment group or a control group who received a placebo.,True,Is the triple 'Albendazole treats helminthiasis' supported by the sentence: 'The study population was assessed for helminthic infection and those found to be positive were randomly assigned to either an albendazole treatment group or a control group who received a placebo.'?,"Yes, this statement does indirectly support the claim that Albendazole treats helminthiasis. The study population was assessed for helminthic infection, which is a type of parasitic infection caused by worms, also known as helminths. Those found to be positive were then randomly assigned to either an albendazole treatment group or a control group who received a placebo. The fact that albendazole was given to those infected with helminths suggests that it is used as a treatment for such infections, thus supporting the claim." -7789677,Albendazole treats strongyloidiasis,1009,"To determine the host factors involved in response to treatment, 46 patients with strongyloidiasis were treated with albendazole, followed-up for 1 year, and separated into two groups: cured and non-cured.",True,"Is the triple 'Albendazole treats strongyloidiasis' supported by the sentence: 'To determine the host factors involved in response to treatment, 46 patients with strongyloidiasis were treated with albendazole, followed-up for 1 year, and separated into two groups: cured and non-cured.'?","Yes, it is indirectly supported because it mentions patients with strongyloidiasis being treated with albendazole, which suggests albendazole can be used to treat strongyloidiasis. The rest of the sentence discusses follow-up procedures, but it doesn't detract from this basic inference." -7640018,Albendazole treats filarial elephantiasis,1010,The role of albendazole in programmes to eliminate lymphatic filariasis.,True,Is the triple 'Albendazole treats filarial elephantiasis' supported by the sentence: 'The role of albendazole in programmes to eliminate lymphatic filariasis.'?,"Yes, the statement ""The role of albendazole in programmes to eliminate lymphatic filariasis"" does indirectly support the claim that albendazole treats filarial elephantiasis, which is a manifestation of lymphatic filariasis. This is because albendazole is often used in programs aimed at eliminating lymphatic filariasis, suggesting it has some therapeutic effect on the disease. However, it's important to note that this doesn't directly prove that albendazole can treat filarial elephantiasis, as it may be used for preventative measures or to target other stages of the disease." -7620262,Albendazole treats Hookworm Infections,1011,On the basis of our results the single 400 mg dose of albendazole is the treatment of choice for hookworm infections in this region of Mali.,True,Is the triple 'Albendazole treats Hookworm Infections' supported by the sentence: 'On the basis of our results the single 400 mg dose of albendazole is the treatment of choice for hookworm infections in this region of Mali.'?,"Yes, this is indirectly supported because if albendazole is recommended as the treatment for hookworm infections, it implies that albendazole is effective against hookworm infections, which aligns with the statement that albendazole treats hookworm infections." -7226097,Albendazole treats cysticercosis,1012,The efficacy of albendazole (15 mg/kg/d for 1 week) was compared with praziquantel (100 mg/kg in three divided doses at 2-hour intervals) for therapy of parenchymal brain cysticercosis.,True,Is the triple 'Albendazole treats cysticercosis' supported by the sentence: 'The efficacy of albendazole (15 mg/kg/d for 1 week) was compared with praziquantel (100 mg/kg in three divided doses at 2-hour intervals) for therapy of parenchymal brain cysticercosis.'?,"Yes, the sentence does indirectly support the statement that Albendazole treats cysticercosis. The sentence is comparing the efficacy of Albendazole and Praziquantel in treating parenchymal brain cysticercosis, which implies that Albendazole is indeed used in treating this condition. However, it does not directly state that Albendazole treats cysticercosis, hence the term 'indirectly'." -25678577,Latamoxef treats bacterial infectious disease,1013,"Clinical efficacy and safety of a new oxacephem, moxalactam, in serious bacterial infections.",True,"Is the triple 'Latamoxef treats bacterial infectious disease' supported by the sentence: 'Clinical efficacy and safety of a new oxacephem, moxalactam, in serious bacterial infections.'?","Yes, the sentence does indirectly support the statement that Latamoxef, which is an oxacephem like moxalactam, treats bacterial infections. The sentence mentions the clinical efficacy and safety of moxalactam in treating serious bacterial infections, suggesting that other drugs in the same class, like Latamoxef, would have similar effects. However, it's important to note that this is an indirect inference and direct evidence should be sought for specific claims about drugs and their uses." -26824955,Ibuprofen treats spondylosis,1014,A comparison of the short-term effects of ibuprofen and diclofenac in spondylosis.,True,Is the triple 'Ibuprofen treats spondylosis' supported by the sentence: 'A comparison of the short-term effects of ibuprofen and diclofenac in spondylosis.'?,"Yes, this sentence does indirectly support the statement that Ibuprofen treats spondylosis. The sentence mentions a comparison of short-term effects of Ibuprofen and another drug in the context of spondylosis, which implies that Ibuprofen is used to treat this condition, even if only in comparison to another drug for research purposes." -25670779,Ibuprofen treats sunburn,1015,"The data suggest that ibuprofen is more effective than placebo for the relief of symptoms associated with UV-B-induced inflammation after high dose UV-B phototherapy for psoriasis, but the drug has limited usefulness in the treatment of sunburn reaction from these same doses.",True,"Is the triple 'Ibuprofen treats sunburn' supported by the sentence: 'The data suggest that ibuprofen is more effective than placebo for the relief of symptoms associated with UV-B-induced inflammation after high dose UV-B phototherapy for psoriasis, but the drug has limited usefulness in the treatment of sunburn reaction from these same doses.'?","Yes, this statement does indirectly support the claim that ibuprofen can treat sunburn, as it shows evidence for ibuprofen being effective in relieving symptoms associated with UV-B-induced inflammation, which is what occurs during sunburns. However, it also states that ibuprofen has limited usefulness in treating sunburn reactions from high dose UV-B phototherapy, suggesting its effectiveness may be limited when used specifically for treating severe phototherapy-induced inflammation, as opposed to regular sunburns from natural sunlight exposure." -25518118,Ibuprofen treats Fractured ankle,1016,"Huoxue Huayu Recipe combined with ibuprofen can reduce inflammatory factors levels in patients with ankle fracture, improve isokinetic muscle strength and ankle function, and accelerate the recovery of patients.",False,"Is the triple 'Ibuprofen treats Fractured ankle' supported by the sentence: 'Huoxue Huayu Recipe combined with ibuprofen can reduce inflammatory factors levels in patients with ankle fracture, improve isokinetic muscle strength and ankle function, and accelerate the recovery of patients.'?","No, this statement does not indirectly support the claim that Ibuprofen treats fractured ankles. The sentence provided discusses the benefits of combining Huoxue Huayu Recipe with Ibuprofen in reducing inflammatory factors, improving muscle strength, and accelerating recovery in patients with ankle fractures, but it does not directly mention, nor imply, that Ibuprofen alone can treat fractured ankles." -25321029,Ibuprofen treats bronchopulmonary dysplasia,1017,"Treatment of newborn rat pups with ibuprofen reduced pulmonary vessel density in the developing lung, but also attenuated experimental BPD by reducing lung inflammation, alveolar enlargement, alveolar septum thickness and small arteriolar wall thickening.",True,"Is the triple 'Ibuprofen treats bronchopulmonary dysplasia' supported by the sentence: 'Treatment of newborn rat pups with ibuprofen reduced pulmonary vessel density in the developing lung, but also attenuated experimental BPD by reducing lung inflammation, alveolar enlargement, alveolar septum thickness and small arteriolar wall thickening.'?","Yes, this sentence does indirectly support the statement that ibuprofen can treat bronchopulmonary dysplasia (BPD). The sentence mentions that ibuprofen reduces lung inflammation, alveolar enlargement, alveolar septum thickness, and small arteriolar wall thickening in newborn rat pups, which are all factors associated with BPD. Therefore, it can be inferred that ibuprofen could potentially have therapeutic effects on BPD, although this is based on an animal study and would need to be confirmed in human trials before making definitive conclusions about its efficacy in treating BPD." -22125431,Ibuprofen treats preeclampsia,1018,Introduction: The comparison of ibuprofen with acetaminophen for blood pressure (BP) in preeclampsia remains controversial.,False,Is the triple 'Ibuprofen treats preeclampsia' supported by the sentence: 'Introduction: The comparison of ibuprofen with acetaminophen for blood pressure (BP) in preeclampsia remains controversial.'?,"No, this sentence does not indirectly support the statement that ibuprofen treats preeclampsia. The sentence only mentions a controversy about whether ibuprofen is more effective than acetaminophen in reducing blood pressure in patients with preeclampsia. It does not imply that ibuprofen is a treatment for preeclampsia." -21268743,Ibuprofen treats glioma,1019,"Taken together, our findings reveal that ibuprofen could induce ferroptosis of glioblastoma cells via downregulation of Nrf2 signaling pathway and is a potential drug for glioma treatment.",True,"Is the triple 'Ibuprofen treats glioma' supported by the sentence: 'Taken together, our findings reveal that ibuprofen could induce ferroptosis of glioblastoma cells via downregulation of Nrf2 signaling pathway and is a potential drug for glioma treatment.'?","Yes, this statement does indirectly support the idea that ibuprofen could treat gliomas, which is a type of brain tumor known as glioblastomas in this context. The sentence mentions that ibuprofen can induce ferroptosis in glioblastoma cells, which is a form of programmed cell death. It also suggests that this occurs via downregulation of the Nrf2 signaling pathway, which is often involved in cancer progression. Therefore, this statement suggests that ibuprofen could potentially be used as a treatment for gliomas, as it can target and kill these cancer cells through ferroptosis induction." -20821983,Ibuprofen treats common cold,1020,Ibuprofen (IBU) and phenylephrine hydrochloride (PE) were commonly used for common cold due to their different effects in relieving fever and the main symptoms such as nasal congestion and high sinus pressure.,False,Is the triple 'Ibuprofen treats common cold' supported by the sentence: 'Ibuprofen (IBU) and phenylephrine hydrochloride (PE) were commonly used for common cold due to their different effects in relieving fever and the main symptoms such as nasal congestion and high sinus pressure.'?,"No, this statement does not indirectly support the claim that Ibuprofen treats common cold. The sentence only mentions that Ibuprofen (IBU) and phenylephrine hydrochloride (PE) were commonly used for treating symptoms associated with the common cold, not that they treat the common cold itself." -20285347,Ibuprofen treats periodontitis,1021,"Therefore, the objective of this study was to investigate the local delivery of the NSAIDs model drug ibuprofen to treat periodontitis using different types of gel formulations (hydrogel, oleogel, and bigel).",True,"Is the triple 'Ibuprofen treats periodontitis' supported by the sentence: 'Therefore, the objective of this study was to investigate the local delivery of the NSAIDs model drug ibuprofen to treat periodontitis using different types of gel formulations (hydrogel, oleogel, and bigel).'?","Yes, this is indirectly supported. The sentence states that there is an investigation into using ibuprofen in various gel formulations to treat periodontitis, which implies that ibuprofen has potential therapeutic effects on periodontitis, thus indirectly supporting the statement 'ibuprofen treats periodontitis'. However, it should be noted this is based on an ongoing study, so further research is needed to fully validate this claim." -19270581,Ibuprofen treats bone fracture,1022,Does the Use of Ibuprofen in Children with Extremity Fractures Increase their Risk for Bone Healing Complications?,False,Is the triple 'Ibuprofen treats bone fracture' supported by the sentence: 'Does the Use of Ibuprofen in Children with Extremity Fractures Increase their Risk for Bone Healing Complications?'?,"No, this statement does not indirectly support the claim that ibuprofen treats bone fractures. In fact, it suggests the opposite - that ibuprofen use in children with extremity fractures may increase their risk for bone healing complications. This could imply that ibuprofen might not be beneficial for treating bone fractures, but rather could potentially hinder the healing process." -17621968,Ibuprofen treats Cognitive impairment,1023,"Finally, anti-inflammatory drug ibuprofen ameliorated the peripheral surgical wounding-induced cognitive impairment in 18 month-old mice.",True,"Is the triple 'Ibuprofen treats Cognitive impairment' supported by the sentence: 'Finally, anti-inflammatory drug ibuprofen ameliorated the peripheral surgical wounding-induced cognitive impairment in 18 month-old mice.'?","Yes, this statement could indirectly support the claim that ibuprofen can treat cognitive impairment. The sentence states that ibuprofen, an anti-inflammatory drug, ameliorated cognitive impairment in mice induced by peripheral surgical wounding. This suggests that ibuprofen may have a positive effect on cognitive function in certain conditions, thus providing some indirect support for its potential use in treating cognitive impairment. However, it is important to note that this is based on a study in mice, not humans, and further research is needed to confirm these findings in humans before any definitive conclusions can be drawn." -17292168,Ibuprofen treats Chronic pain,1024,"In the last several years, several topical NSAIDs including either diclofenac ibuprofen or salicylates for chronic pain have been approved in the United States while similar drugs have been available in Europe for years.",True,"Is the triple 'Ibuprofen treats Chronic pain' supported by the sentence: 'In the last several years, several topical NSAIDs including either diclofenac ibuprofen or salicylates for chronic pain have been approved in the United States while similar drugs have been available in Europe for years.'?","Yes, this statement does indirectly support the claim that ibuprofen can be used to treat chronic pain. The sentence mentions that topical NSAIDs, including ibuprofen, have been approved in the United States for treating chronic pain, which implies their efficacy in managing such conditions. However, it is essential to note that this evidence is indirect, as it does not directly show ibuprofen being used to treat chronic pain but rather states its approval for such use, assuming its proven efficacy in clinical trials to receive approval for marketing in this context." -15258520,Ibuprofen treats cardiovascular disorder,1025,Patent ductus arteriosus (PDA) is the most common cardiovascular abnormality of the preterm infant usually treated with ibuprofen (IBU).,True,Is the triple 'Ibuprofen treats cardiovascular disorder' supported by the sentence: 'Patent ductus arteriosus (PDA) is the most common cardiovascular abnormality of the preterm infant usually treated with ibuprofen (IBU).'?,"Yes, this statement could indirectly support the claim that Ibuprofen treats cardiovascular disorders, as it mentions Ibuprofen being used to treat Patent ductus arteriosus (PDA), which is a congenital heart defect (cardiovascular abnormality). However, it does not directly support the claim, as it does not state that Ibuprofen improves the overall condition of the cardiovascular system, but rather it is used to treat a specific condition in preterm infants." -13826476,"Ibuprofen treats osteoarthritis, spine",1026,"In an open three-center pilot study, 17 patients suffering from chronic persistent pain syndrome, due to osteoarthritis of the hip and knee or spondylarthrosis, were treated orally with 1800-2400 mg Ibuprofen per day for 3 weeks.",True,"Is the triple 'Ibuprofen treats osteoarthritis, spine' supported by the sentence: 'In an open three-center pilot study, 17 patients suffering from chronic persistent pain syndrome, due to osteoarthritis of the hip and knee or spondylarthrosis, were treated orally with 1800-2400 mg Ibuprofen per day for 3 weeks.'?","Yes, this sentence does indirectly support the statement. The sentence mentions that 17 patients suffering from chronic persistent pain syndrome, due to osteoarthritis of the hip and knee or spondylarthrosis, were treated with Ibuprofen for 3 weeks, which implies that Ibuprofen is used to treat these conditions, including osteoarthritis and spinal issues. However, it doesn't directly mention that Ibuprofen treats osteoarthritis, spine, but it does provide evidence for its use in treating symptoms associated with these conditions." -13722152,Ibuprofen treats Neck pain,1027,"The patient presented with a 6-month history of neck pain with radiation into the shoulder and arm on the left side, which was relieved by ibuprofen.",True,"Is the triple 'Ibuprofen treats Neck pain' supported by the sentence: 'The patient presented with a 6-month history of neck pain with radiation into the shoulder and arm on the left side, which was relieved by ibuprofen.'?","Yes, this statement does indirectly support the claim that Ibuprofen can treat neck pain, as it mentions that it relieved the patient's neck pain, shoulder pain, and arm pain on the left side, which were symptoms they had been experiencing for 6 months. However, it should be noted that this is based on one patient's experience, so it doesn't necessarily mean that Ibuprofen will work for everyone with neck pain, as individual responses to medication can vary widely." -11790277,Ibuprofen treats hypertensive disorder,1028,"Treatment with nonselective anti-inflammatory drugs ibuprofen, indomethacin, or salicylic acid did not show any effect on angiotensin II-induced superoxide production, hypertension, or cardiac hypertrophy.",False,"Is the triple 'Ibuprofen treats hypertensive disorder' supported by the sentence: 'Treatment with nonselective anti-inflammatory drugs ibuprofen, indomethacin, or salicylic acid did not show any effect on angiotensin II-induced superoxide production, hypertension, or cardiac hypertrophy.'?","No, this statement does not support the claim that ibuprofen treats hypertensive disorders. In fact, it suggests the opposite - that ibuprofen does not have an effect on angiotensin II-induced superoxide production, hypertension, or cardiac hypertrophy, which are all associated with hypertensive disorders." -11536369,Ibuprofen treats seasonal allergic rhinitis,1029,Addition of ibuprofen to pseudoephedrine and chlorpheniramine in the treatment of seasonal allergic rhinitis.,True,Is the triple 'Ibuprofen treats seasonal allergic rhinitis' supported by the sentence: 'Addition of ibuprofen to pseudoephedrine and chlorpheniramine in the treatment of seasonal allergic rhinitis.'?,"Yes, this statement does indirectly support the claim that ibuprofen can be used to treat seasonal allergic rhinitis. The sentence suggests that ibuprofen was added to pseudoephedrine and chlorpheniramine in the treatment regimen for this condition, implying its effectiveness in treating this condition when used in combination with other medications. However, it does not provide direct evidence for ibuprofen as a standalone treatment for this condition, which means further research would be needed to confirm its efficacy as such." -11381904,Ibuprofen treats Premature birth,1030,This should be considered to assess pharmacokinetic-pharmacodynamic relationships of ibuprofen in premature neonates and subsequently to understand and refine the use of ibuprofen in managing PDA either as a prophylactic or curative treatment.,False,Is the triple 'Ibuprofen treats Premature birth' supported by the sentence: 'This should be considered to assess pharmacokinetic-pharmacodynamic relationships of ibuprofen in premature neonates and subsequently to understand and refine the use of ibuprofen in managing PDA either as a prophylactic or curative treatment.'?,"No, this sentence does not indirectly support the statement that ibuprofen treats premature birth. The sentence discusses pharmacokinetic-pharmacodynamic relationships of ibuprofen in premature neonates, which is related to understanding and refining its use in managing PDA (Patent Ductus Arteriosus), but it does not explicitly state or imply that ibuprofen can prevent premature birth itself." -11239637,Ibuprofen treats Back pain,1031,"A 57-year-old woman believed that ibuprofen, prescribed for back pain, improved her idiopathic chronic cough that had been resistant to inhaled and oral corticosteroids.",True,"Is the triple 'Ibuprofen treats Back pain' supported by the sentence: 'A 57-year-old woman believed that ibuprofen, prescribed for back pain, improved her idiopathic chronic cough that had been resistant to inhaled and oral corticosteroids.'?","Yes, this statement does provide indirect support for the claim that Ibuprofen treats back pain in relation to the woman's chronic cough, as it suggests that Ibuprofen, which was prescribed for her back pain, had some positive effect on her condition. However, it does not directly support the claim, as it involves an indirect link through another medical condition (her chronic cough). This is because it does not confirm whether Ibuprofen specifically improved her back pain, but rather implies it had an effect on her overall well-being, which in turn may have influenced her back pain indirectly." -10195210,Ibuprofen treats influenza,1032,"A multicenter, randomized, double-blind, double-dummy, placebo- and active-controlled, parallel-group comparison of diclofenac-K and ibuprofen for the treatment of adults with influenza-like symptoms.",False,"Is the triple 'Ibuprofen treats influenza' supported by the sentence: 'A multicenter, randomized, double-blind, double-dummy, placebo- and active-controlled, parallel-group comparison of diclofenac-K and ibuprofen for the treatment of adults with influenza-like symptoms.'?","No, this statement is not indirectly supported by the given sentence. The provided sentence is comparing two different medications, diclofenac-K and ibuprofen, in relation to treating adults with influenza-like symptoms, but it does not imply that ibuprofen specifically is effective in treating influenza itself. The statement only indicates that ibuprofen may be used to alleviate symptoms associated with influenza-like illnesses, not to actually treat the underlying infection caused by the influenza virus." -9950431,Ibuprofen treats rheumatic disorder,1033,"Eight preparations contained synthetic drugs (e.g. benzodiazepines and tricyclic antidepressants in sedative preparations, cyproheptadine in a remedy to gain bodyweight, ibuprofen and dipyrone in herbal capsules used to treat rheumatism).",True,"Is the triple 'Ibuprofen treats rheumatic disorder' supported by the sentence: 'Eight preparations contained synthetic drugs (e.g. benzodiazepines and tricyclic antidepressants in sedative preparations, cyproheptadine in a remedy to gain bodyweight, ibuprofen and dipyrone in herbal capsules used to treat rheumatism).'?","Yes, this statement does indirectly support the claim that Ibuprofen can be used to treat rheumatic disorders. The user's sentence mentions that ibuprofen is found in herbal capsules used to treat rheumatism, which aligns with the claim that ibuprofen can be used for treating rheumatic disorders. However, it should be noted that this is an indirect inference, as the original claim does not directly state that ibuprofen is used for treating rheumatism, but rather lists it as an ingredient in a treatment for rheumatism." -9913360,Ibuprofen treats Myalgia,1034,Preliminary comparison of bromelain and Ibuprofen for delayed onset muscle soreness management.,True,Is the triple 'Ibuprofen treats Myalgia' supported by the sentence: 'Preliminary comparison of bromelain and Ibuprofen for delayed onset muscle soreness management.'?,"Yes, this statement is indirectly supported by the given sentence. The sentence mentions bromelain, which is an enzyme found in pineapple, in relation to delayed onset muscle soreness management, while also mentioning Ibuprofen, which is a well-known pain reliever used for various conditions including myalgia (muscle pain). The indirect connection lies in the fact they both have potential in managing pain related to muscle soreness, although in different ways - Ibuprofen as a pain reliever, and bromelain as an anti-inflammatory agent." -9550056,Ibuprofen treats Acute Pain,1035,"BACKGROUND: Rofecoxib is a selective cyclooxygenase-2 inhibitor indicated for the treatment of acute pain, with similar analgesic efficacy to ibuprofen and naproxen sodium.",True,"Is the triple 'Ibuprofen treats Acute Pain' supported by the sentence: 'BACKGROUND: Rofecoxib is a selective cyclooxygenase-2 inhibitor indicated for the treatment of acute pain, with similar analgesic efficacy to ibuprofen and naproxen sodium.'?","Yes, this sentence does indirectly support the claim that ibuprofen can treat acute pain, as it mentions rofecoxib has similar analgesic efficacy to ibuprofen for this purpose. The term 'analgesic efficacy' refers to the ability to treat pain, so this suggests ibuprofen is effective for treating acute pain, as stated in the original sentence." -9536612,Ibuprofen treats Low back pain,1036,CONCLUSION: Continuous low-level heat wrap therapy was superior to both acetaminophen and ibuprofen for treating low back pain.,False,Is the triple 'Ibuprofen treats Low back pain' supported by the sentence: 'CONCLUSION: Continuous low-level heat wrap therapy was superior to both acetaminophen and ibuprofen for treating low back pain.'?,"No, this statement does not indirectly support the claim that ibuprofen treats low back pain. In fact, it suggests the opposite - that continuous low-level heat wrap therapy was superior to ibuprofen for treating low back pain." -9444914,Ibuprofen treats Arthralgia,1037,"To determine the effectiveness of oral glucosamine with ibuprofen for the relief of joint pain in osteoarthritis a mini-review (Griffiths, 2002) of double-blind randomized controlled trials comparing the two was undertaken.",False,"Is the triple 'Ibuprofen treats Arthralgia' supported by the sentence: 'To determine the effectiveness of oral glucosamine with ibuprofen for the relief of joint pain in osteoarthritis a mini-review (Griffiths, 2002) of double-blind randomized controlled trials comparing the two was undertaken.'?","No, this sentence does not indirectly support the statement that Ibuprofen treats arthralgia (joint pain). The sentence is discussing a review of studies comparing oral glucosamine to Ibuprofen for osteoarthritis joint pain relief, not whether Ibuprofen specifically is effective in treating arthralgia, which is already established in medical literature." -9436288,Ibuprofen treats Alzheimer disease,1038,"In conclusion, NCX-2216 is more efficacious than ibuprofen or celecoxib in clearing Abeta deposits from the brains of Tg mice, implying potential benefit in the treatment of Alzheimer's dementia.",False,"Is the triple 'Ibuprofen treats Alzheimer disease' supported by the sentence: 'In conclusion, NCX-2216 is more efficacious than ibuprofen or celecoxib in clearing Abeta deposits from the brains of Tg mice, implying potential benefit in the treatment of Alzheimer's dementia.'?","No, this statement does not indirectly support the idea that ibuprofen treats Alzheimer's disease. The sentence in question discusses the efficacy of NCX-2216 in clearing Abeta deposits from the brains of Tg mice, which is compared to ibuprofen and celecoxib. However, it does not mention or imply that ibuprofen has any direct effect on treating Alzheimer's disease. Instead, it only compares the efficacy of these substances in clearing Abeta deposits, which is one aspect of Alzheimer's research, but it does not confirm that ibuprofen is an effective treatment for Alzheimer's disease." -9104501,Ibuprofen treats injury,1039,"Ibuprofen attenuates early lung injury in endotoxemic, neutropenic rats.",True,"Is the triple 'Ibuprofen treats injury' supported by the sentence: 'Ibuprofen attenuates early lung injury in endotoxemic, neutropenic rats.'?","Yes, this statement is indirectly supported by the given sentence, as it suggests that ibuprofen has an effect on reducing lung injury in rats, which can be interpreted as treating an injury. However, it is important to note that this is an extrapolation, as human injuries may differ significantly from lung injuries in rats, and ibuprofen may not have the same effect in all types of injuries in humans." -8748381,Ibuprofen treats Dysmenorrhea,1040,CONCLUSION: Continuous low-level topical heat therapy was as effective as ibuprofen for the treatment of dysmenorrhea.,True,Is the triple 'Ibuprofen treats Dysmenorrhea' supported by the sentence: 'CONCLUSION: Continuous low-level topical heat therapy was as effective as ibuprofen for the treatment of dysmenorrhea.'?,"Yes, this statement can be interpreted as indirectly supporting the claim that Ibuprofen treats dysmenorrhea (period pain). The conclusion states that continuous low-level topical heat therapy is as effective as ibuprofen in treating dysmenorrhea. This implies that ibuprofen does indeed have an effect on dysmenorrhea, thus providing support for the claim, albeit indirectly. However, it's important to note that this conclusion is based on a comparison between heat therapy and ibuprofen, not between ibuprofen and no treatment at all. Therefore, it doesn't directly prove that ibuprofen is effective in treating dysmenorrhea, only that it's at least as effective as heat therapy." -8698382,Ibuprofen treats Tension-type headache,1041,Is the combination of ibuprofen and caffeine effective for the treatment of a tension-type headache?,True,Is the triple 'Ibuprofen treats Tension-type headache' supported by the sentence: 'Is the combination of ibuprofen and caffeine effective for the treatment of a tension-type headache?'?,"Yes, this statement is indirectly supported by the provided sentence. The sentence suggests that ibuprofen, when combined with caffeine, is effective for treating tension-type headaches. This implies that ibuprofen alone could also have some efficacy in treating tension-type headaches, even though it might not be as effective as the combination. Therefore, it provides indirect support for the statement that ibuprofen can treat tension-type headaches, as in the triple ""Ibuprofen treats Tension-type headache""." -8452594,Ibuprofen treats migraine disorder,1042,"Evaluation of a novel solubilized formulation of ibuprofen in the treatment of migraine headache: a randomized, double-blind, placebo-controlled, dose-ranging study.",True,"Is the triple 'Ibuprofen treats migraine disorder' supported by the sentence: 'Evaluation of a novel solubilized formulation of ibuprofen in the treatment of migraine headache: a randomized, double-blind, placebo-controlled, dose-ranging study.'?","Yes, this sentence does indirectly support the statement that ibuprofen treats migraine disorder. The sentence is from a clinical study where ibuprofen is used in treating migraines in a randomized, double-blind, placebo-controlled, dose-ranging study, which implies that ibuprofen has been tested for its efficacy in treating migraines, thus providing evidence for its use in treating migraines, as mentioned in the initial statement." -8420965,Ibuprofen treats Hemorrhage,1043,"A randomized trial measuring fecal blood loss after treatment with rofecoxib, ibuprofen, or placebo in healthy subjects.",False,"Is the triple 'Ibuprofen treats Hemorrhage' supported by the sentence: 'A randomized trial measuring fecal blood loss after treatment with rofecoxib, ibuprofen, or placebo in healthy subjects.'?","No, this statement is not indirectly supported by the sentence provided. The sentence describes a randomized trial measuring fecal blood loss after treatment with rofecoxib, ibuprofen, or placebo in healthy subjects, but it does not mention hemorrhage or suggest that ibuprofen treats hemorrhage." -8397426,Ibuprofen treats rheumatoid arthritis,1044,Ibuprofen or aspirin in rheumatoid arthritis therapy.,True,Is the triple 'Ibuprofen treats rheumatoid arthritis' supported by the sentence: 'Ibuprofen or aspirin in rheumatoid arthritis therapy.'?,"Yes, this statement can be seen as indirectly supporting the claim that ibuprofen can be used to treat rheumatoid arthritis. The sentence ""Ibuprofen or aspirin in rheumatoid arthritis therapy"" suggests that both ibuprofen and aspirin can be used in the treatment of rheumatoid arthritis, which aligns with the first statement that ibuprofen can be used to treat this condition. However, it should be noted that this is an indirect inference, as the sentence does not explicitly state that ibuprofen is used for treating rheumatoid arthritis, but rather includes it as one among other possible treatments in this context." -7887942,Ibuprofen treats osteoarthritis,1045,"DESIGN: Ginger extract was compared to placebo and Ibuprofen in patients with osteoarthritis of the hip or knee in a controlled, double blind, double dummy, cross-over study with a wash-out period of one week followed by three treatment periods in a randomized sequence, each of three weeks duration.",True,"Is the triple 'Ibuprofen treats osteoarthritis' supported by the sentence: 'DESIGN: Ginger extract was compared to placebo and Ibuprofen in patients with osteoarthritis of the hip or knee in a controlled, double blind, double dummy, cross-over study with a wash-out period of one week followed by three treatment periods in a randomized sequence, each of three weeks duration.'?","Yes, this sentence indirectly supports the statement that Ibuprofen treats osteoarthritis. The sentence mentions a controlled, double-blind, double-dummy, cross-over study where Ibuprofen was used in patients with osteoarthritis of the hip or knee. The fact that Ibuprofen was used in a medical study for treating patients with osteoarthritis suggests that it has therapeutic effects on this condition, thus supporting the claim." -7852264,Ibuprofen treats Headache,1046,"Besides oxygen, acetazolamide, dexamethasone and especially inhibitors of prostaglandin synthesis such as ibuprofen and naproxen are approved for the treatment of HAH.",True,"Is the triple 'Ibuprofen treats Headache' supported by the sentence: 'Besides oxygen, acetazolamide, dexamethasone and especially inhibitors of prostaglandin synthesis such as ibuprofen and naproxen are approved for the treatment of HAH.'?","Yes, this statement indirectly supports the claim that Ibuprofen can treat headaches (HAH). The sentence mentions Ibuprofen as one of the approved inhibitors of prostaglandin synthesis for treating headaches, which aligns with the statement that Ibuprofen can be used to treat headaches (HAH)." -7851777,Ibuprofen treats patent ductus arteriosus,1047,OBJECTIVE: To evaluate the effect of intravenous ibuprofen and indomethacin for treatment of patent ductus arteriosus (PDA) on mesenteric and renal blood flow velocity in preterm infants.,True,Is the triple 'Ibuprofen treats patent ductus arteriosus' supported by the sentence: 'OBJECTIVE: To evaluate the effect of intravenous ibuprofen and indomethacin for treatment of patent ductus arteriosus (PDA) on mesenteric and renal blood flow velocity in preterm infants.'?,"Yes, this statement does provide indirect support for the claim that ibuprofen can treat patent ductus arteriosus (PDA). The objective of the study mentioned is to evaluate the effect of intravenous ibuprofen (and indomethacin) on blood flow velocity in preterm infants with PDA. This implies that ibuprofen is being used as a treatment for PDA, thus providing support for the claim. However, it's important to note that the study is primarily focused on the effects of ibuprofen on blood flow velocity, not on its overall effectiveness as a PDA treatment." -7732956,Ibuprofen treats Pain,1048,"The WOMAC detected significant differences between ibuprofen and placebo for pain and physical functioning, whereas the SF-36 detected differences for the bodily pain subscale.",True,"Is the triple 'Ibuprofen treats Pain' supported by the sentence: 'The WOMAC detected significant differences between ibuprofen and placebo for pain and physical functioning, whereas the SF-36 detected differences for the bodily pain subscale.'?","Yes, this statement does provide indirect support for the claim that ibuprofen treats pain. The sentence mentions significant differences in pain levels between those who took ibuprofen (compared to those who took placebo), as detected by two different measurement tools (WOMAC and SF-36). This implies that ibuprofen had an impact on pain, which aligns with the statement that ibuprofen is used to treat pain." -7686895,Ibuprofen treats arthritic joint disease,1049,"I take ibuprofen regularly for my arthritis, but I've heard that it may lead to kidney damage.",True,"Is the triple 'Ibuprofen treats arthritic joint disease' supported by the sentence: 'I take ibuprofen regularly for my arthritis, but I've heard that it may lead to kidney damage.'?","Yes, this statement is indirectly supported by the sentence given. The statement says that ibuprofen is used for treating arthritis, which is correct, but it also suggests that regular use could lead to kidney damage, which is an indirect reference to its potential side effects on non-joint organs like the kidneys, which may be impacted due to long-term usage." -7258310,Ibuprofen treats Fever,1050,Paracetamol or ibuprofen in febrile children.,True,Is the triple 'Ibuprofen treats Fever' supported by the sentence: 'Paracetamol or ibuprofen in febrile children.'?,"Yes, this statement does indirectly support the claim that ibuprofen can treat fever, as it lists ibuprofen as an option for treating febrile children, which implies its use in reducing fever symptoms. However, it should be noted that this statement is not an explicit endorsement, but rather an indirect one based on its suggested use in treating fevers in children." -7210912,Ibuprofen treats Toothache,1051,"A double-blind, parallel-group study compared the analgesic efficacy of rofecoxib to placebo and ibuprofen in 102 patients with dental pain.",True,"Is the triple 'Ibuprofen treats Toothache' supported by the sentence: 'A double-blind, parallel-group study compared the analgesic efficacy of rofecoxib to placebo and ibuprofen in 102 patients with dental pain.'?","Yes, this statement does indirectly support the claim that ibuprofen can treat toothaches. The study mentioned compares rofecoxib to ibuprofen in treating dental pain, which implies that ibuprofen was found to be effective in treating dental pain, also known as toothaches, in this study. However, it is essential to note that this support is indirect because it does not directly mention ibuprofen treating toothaches but rather demonstrates its effectiveness in treating dental pain, which is closely related to toothaches." -25984950,Cefmenoxime treats bacterial infectious disease,1052,Cefmenoxime versus cefoxitin in the treatment of serious bacterial infections.,True,Is the triple 'Cefmenoxime treats bacterial infectious disease' supported by the sentence: 'Cefmenoxime versus cefoxitin in the treatment of serious bacterial infections.'?,"Yes, this statement is indirectly supported by the given sentence. The sentence suggests a comparison between Cefmenoxime and another antibiotic, Cefoxitin, in treating serious bacterial infections. This implies that Cefmenoxime is indeed used to treat bacterial infections, which aligns with the statement 'Cefmenoxime treats bacterial infectious disease'. However, it doesn't directly state that Cefmenoxime is used to treat all types of bacterial infections, so it's an indirect support." -21500374,Ivabradine treats hypotensive disorder,1053,"These are: the association of dobutamine infusion with amiodarone or ivabradine in patients with symptomatic hypotension, and high-dose furosemide associated to hypertonic saline solution, levosimendan, hydralazine/isosorbide dinitrate, sodium nitroprusside or ivabradine in hemodynamically stable patients.",True,"Is the triple 'Ivabradine treats hypotensive disorder' supported by the sentence: 'These are: the association of dobutamine infusion with amiodarone or ivabradine in patients with symptomatic hypotension, and high-dose furosemide associated to hypertonic saline solution, levosimendan, hydralazine/isosorbide dinitrate, sodium nitroprusside or ivabradine in hemodynamically stable patients.'?","Yes, this statement does indirectly support the claim that Ivabradine can treat hypotensive disorders. The sentence mentions Ivabradine in association with amiodarone for patients experiencing symptomatic hypotension, implying its use as a treatment for low blood pressure (hypotension). However, it is important to note that Ivabradine is not being used alone in this context, but rather in combination with other drugs, which suggests it may be part of a broader treatment strategy for managing hypotension, rather than being a standalone treatment for the condition itself." -18841652,Ivabradine treats toxic shock syndrome,1054,If Channel Inhibition With Ivabradine Does Not Improve Cardiac and Vascular Function in Experimental Septic Shock.,False,Is the triple 'Ivabradine treats toxic shock syndrome' supported by the sentence: 'If Channel Inhibition With Ivabradine Does Not Improve Cardiac and Vascular Function in Experimental Septic Shock.'?,"No, this statement does not indirectly support the idea that Ivabradine treats toxic shock syndrome. The sentence provided discusses how channel inhibition with Ivabradine does not improve cardiac and vascular function in experimental septic shock, which is different from toxic shock syndrome. These two conditions, although sharing some symptoms, have different underlying causes, so even if Ivabradine were found to improve cardiac function in one, it would not necessarily mean it would be effective for the other." -18126606,Ivabradine treats mitral valve stenosis,1055,Ivabradine thus can be used effectively and safely in patients with MS in normal sinus rhythm who are intolerant or contraindicated for beta-blocker therapy.,False,Is the triple 'Ivabradine treats mitral valve stenosis' supported by the sentence: 'Ivabradine thus can be used effectively and safely in patients with MS in normal sinus rhythm who are intolerant or contraindicated for beta-blocker therapy.'?,"No, this statement does not indirectly support the claim that Ivabradine treats mitral valve stenosis (MS). The sentence only states that Ivabradine can be used effectively and safely in patients with MS who cannot tolerate or use beta-blocker therapy. It does not imply that Ivabradine can treat or cure MS, only that it can be used as an alternative therapy for symptom management in certain patient populations." -17604342,Ivabradine treats atrial fibrillation,1056,Ivabradine is ineffective in atrial fibrillation.,False,Is the triple 'Ivabradine treats atrial fibrillation' supported by the sentence: 'Ivabradine is ineffective in atrial fibrillation.'?,"No, this is not indirectly supported because the statement explicitly says ivabradine is ineffective in atrial fibrillation, which contradicts the claim it treats the condition." -17604340,Ivabradine treats diastolic heart failure,1057,The aim of the study was to compare the therapeutic effects of ivabradine in diastolic heart failure with preserved left ventricular systolic function.,True,Is the triple 'Ivabradine treats diastolic heart failure' supported by the sentence: 'The aim of the study was to compare the therapeutic effects of ivabradine in diastolic heart failure with preserved left ventricular systolic function.'?,"Yes, this statement does indirectly support the claim that Ivabradine treats diastolic heart failure. The study aims to compare the therapeutic effects of Ivabradine in diastolic heart failure with preserved left ventricular systolic function. This implies that Ivabradine is being used as a treatment for diastolic heart failure, thus providing support for the claim, albeit indirectly, as it does not explicitly state that Ivabradine treats diastolic heart failure, but rather implies it through the context of the study." -15681673,Ivabradine treats multiple organ dysfunction syndrome,1058,CONCLUSIONS: The MODI (f)Y trial is the first application of ivabradine as a pure heart rate reducing agent in MODS patients.,True,Is the triple 'Ivabradine treats multiple organ dysfunction syndrome' supported by the sentence: 'CONCLUSIONS: The MODI (f)Y trial is the first application of ivabradine as a pure heart rate reducing agent in MODS patients.'?,"Yes, the statement does indirectly support the idea that Ivabradine can be used to treat Multiple Organ Dysfunction Syndrome (MODS). The sentence clearly mentions the use of Ivabradine in MODS patients, specifically as a heart rate reducing agent. This implies that Ivabradine has some beneficial effect in managing MODS, thus providing indirect support for its use in treating this condition." -15641743,Ivabradine treats systolic heart failure,1059,Ivabradine added to guidelines-based therapy in systolic heart failure patients.,True,Is the triple 'Ivabradine treats systolic heart failure' supported by the sentence: 'Ivabradine added to guidelines-based therapy in systolic heart failure patients.'?,"Yes, this sentence does indirectly support the statement that Ivabradine treats systolic heart failure. The sentence implies that Ivabradine is being added to guidelines-based therapy for systolic heart failure patients, suggesting that it has some therapeutic effect on this condition. However, it doesn't directly prove that Ivabradine is effective in treating systolic heart failure as it could be used for other purposes such as preventing or managing symptoms. A direct support would be a sentence stating Ivabradine directly improves systolic heart failure." -13559450,Ivabradine treats Tachycardia,1060,"Clinical studies proved the efficacy of ivabradine in patients with stable angina, while clinical data are awaited to verify its probable value in the treatment of atrial tachyarrhythmias and tachycardia due to ventricular dysfunction.",False,"Is the triple 'Ivabradine treats Tachycardia' supported by the sentence: 'Clinical studies proved the efficacy of ivabradine in patients with stable angina, while clinical data are awaited to verify its probable value in the treatment of atrial tachyarrhythmias and tachycardia due to ventricular dysfunction.'?","No, it is not directly supported, but it is indirectly supported based on the mentioning of clinical data being awaited to verify probable value in treatment for atrial tachyarrhythmias, which includes tachycardia due to ventricular dysfunction, and Ivabradine being mentioned as effective for angina, which is often associated with tachycardia, but not explicitly stated to treat it in this sentence alone." -12424888,Ivabradine treats coronary artery disorder,1061,"The effective drug, ivabradine, has demonstrated anti-anginal, anti-ischemic efficacy and now is being tested for its effect on survival in patients with coronary artery disease and impaired left ventricular function, as well as for heart failure.",True,"Is the triple 'Ivabradine treats coronary artery disorder' supported by the sentence: 'The effective drug, ivabradine, has demonstrated anti-anginal, anti-ischemic efficacy and now is being tested for its effect on survival in patients with coronary artery disease and impaired left ventricular function, as well as for heart failure.'?","Yes, this statement does indirectly support the claim that Ivabradine treats coronary artery disease. The sentence mentions Ivabradine being tested for its effect on survival in patients with Coronary Artery Disease (CAD) and impaired left ventricular function, which suggests it is being used as a treatment for CAD. The terms ""anti-anginal"" and ""anti-ischemic"" also indicate it is used to treat symptoms related to CAD, such as chest pain (angina) and reduced blood flow to tissues (ischemia). However, it's important to note that this statement does not directly mention Ivabradine treating CAD, but rather implies it through its described uses and effects." -12164130,Ivabradine treats Stable angina,1062,New agent ivabradine (Procoralan) for treatment of chronic stable angina.,True,Is the triple 'Ivabradine treats Stable angina' supported by the sentence: 'New agent ivabradine (Procoralan) for treatment of chronic stable angina.'?,"Yes, this statement does indirectly support the claim that Ivabradine can be used to treat stable angina. The sentence explicitly mentions Ivabradine as a new agent for treating chronic stable angina, which implies its efficacy in treating this condition. However, it does not directly demonstrate how Ivabradine works to treat stable angina, but rather states its use as an agent for treatment in this context, thus providing an indirect support for the original claim." -11342280,Ivabradine treats cardiovascular disorder,1063,Heart rate lowering by specific and selective I(f) current inhibition with ivabradine: a new therapeutic perspective in cardiovascular disease.,True,Is the triple 'Ivabradine treats cardiovascular disorder' supported by the sentence: 'Heart rate lowering by specific and selective I(f) current inhibition with ivabradine: a new therapeutic perspective in cardiovascular disease.'?,"Yes, the sentence does indirectly support the statement that Ivabradine treats cardiovascular disorders. The sentence explicitly states that Ivabradine inhibits the I(f) current, which leads to heart rate lowering. This is presented as a new therapeutic perspective in cardiovascular disease, implying that Ivabradine is used to treat such disorders." -26843374,Cefixime treats tonsillitis,1064,These results show that cefixime once daily is at least as effective as penicillin V t.i.d. in pharyngitis and tonsillitis in children.,True,Is the triple 'Cefixime treats tonsillitis' supported by the sentence: 'These results show that cefixime once daily is at least as effective as penicillin V t.i.d. in pharyngitis and tonsillitis in children.'?,"Yes, this statement does indirectly support the claim that Cefixime can be used to treat tonsillitis, as pharyngitis and tonsillitis are closely related conditions, both affecting the throat area, and Cefixime is shown to be effective in treating these conditions in children, as mentioned in the sentence. However, it is important to note that direct evidence specifically linking Cefixime to treating tonsillitis may not be present in this statement alone, but it can be inferred based on related conditions it is proven to treat." -23970374,Cefixime treats Infection,1065,The aim of this study is to evaluate cefixime for the treatment of osteoarticular infections in pediatric SCD patients by retrospective design.,True,Is the triple 'Cefixime treats Infection' supported by the sentence: 'The aim of this study is to evaluate cefixime for the treatment of osteoarticular infections in pediatric SCD patients by retrospective design.'?,"Yes, the triple ""Cefixime treats Infection"" is indirectly supported by the sentence. The sentence mentions a study evaluating Cefixime for the treatment of osteoarticular infections in pediatric SCD patients, which implies that Cefixime is being used as a treatment for infection, thus supporting the statement that Cefixime treats infection, albeit indirectly." -22544340,Cefixime treats pharyngitis,1066,Purpose: To report a case of Acute bilateral angle closure and Myopia following oral Cefixime therapy for pharyngitis.,False,Is the triple 'Cefixime treats pharyngitis' supported by the sentence: 'Purpose: To report a case of Acute bilateral angle closure and Myopia following oral Cefixime therapy for pharyngitis.'?,"No, this sentence does not indirectly support the statement that Cefixime treats pharyngitis. The sentence is actually reporting an adverse reaction to Cefixime therapy, not its therapeutic effect." -22138225,Cefixime treats syphilis,1067,DISCUSSION: Demonstration of efficacy of cefixime in the treatment of active syphilis in this Phase 2 trial among non-pregnant women will inform a proposed randomized controlled trial to evaluate cefixime as an alternative treatment for pregnant women with active syphilis to evaluate prevention of congenital syphilis.,True,Is the triple 'Cefixime treats syphilis' supported by the sentence: 'DISCUSSION: Demonstration of efficacy of cefixime in the treatment of active syphilis in this Phase 2 trial among non-pregnant women will inform a proposed randomized controlled trial to evaluate cefixime as an alternative treatment for pregnant women with active syphilis to evaluate prevention of congenital syphilis.'?,"Yes, the statement does provide indirect support for the idea that Cefixime can treat Syphilis. The discussion mentions a trial demonstrating the efficacy of Cefixime in treating active Syphilis in non-pregnant women, which suggests that Cefixime has some positive effect on Syphilis. However, it does not directly state that Cefixime can cure Syphilis, but rather it informs a proposed trial to evaluate Cefixime as an alternative treatment for pregnant women with active Syphilis to prevent congenital Syphilis. Therefore, while there is some support, it is indirect and limited in scope." -20619094,Cefixime treats bronchitis,1068,"Two weeks following her return to France, the patient presented with an episode of bronchitis and received 5 days of treatment with cefixime (a third-generation cephalosporin).",True,"Is the triple 'Cefixime treats bronchitis' supported by the sentence: 'Two weeks following her return to France, the patient presented with an episode of bronchitis and received 5 days of treatment with cefixime (a third-generation cephalosporin).'?","Yes, this sentence does indirectly support the claim that Cefixime can treat bronchitis, as it mentions a patient being treated for an episode of bronchitis using Cefixime as the medication. However, it doesn't directly address whether Cefixime is an effective treatment for bronchitis, as it only describes one instance where it was used for treatment, not whether it was successful in treating the condition." -12941415,Cefixime treats otitis media,1069,Efficacy and tolerability of cefixime in otitis media.,True,Is the triple 'Cefixime treats otitis media' supported by the sentence: 'Efficacy and tolerability of cefixime in otitis media.'?,"Yes, this statement does indirectly support the claim that Cefixime treats Otitis Media. The sentence ""Efficacy and tolerability of cefixime in Otitis Media"" suggests that Cefixime has been tested for its effectiveness in treating Otitis Media, which implies that it is used as a treatment for this condition. However, it does not directly state that Cefixime treats Otitis Media, hence the indirect support." -8827692,Cefixime treats gonorrhea,1070,A randomized trial of ciprofloxacin versus cefixime for treatment of gonorrhea after rapid emergence of gonococcal ciprofloxacin resistance in The Philippines.,True,Is the triple 'Cefixime treats gonorrhea' supported by the sentence: 'A randomized trial of ciprofloxacin versus cefixime for treatment of gonorrhea after rapid emergence of gonococcal ciprofloxacin resistance in The Philippines.'?,"Yes, this statement does indirectly support the claim that Cefixime treats Gonorrhea, as it mentions Cefixime being used in a trial for treatment of Gonorrhea, implying its efficacy against it to some extent, however it does not directly support Cefixime treating Gonorrhea after resistance to Ciprofloxacin has emerged, as it only mentions its use in general for Gonorrhea treatment, not specifically post-resistance treatment." -7594422,Cefixime treats bacterial infectious disease,1071,A randomized controlled clinical study of cefetamet pivoxil (CAT) compared with cefixime (CFX) was conducted to evaluate its safety and efficacy in treating bacterial infections.,True,Is the triple 'Cefixime treats bacterial infectious disease' supported by the sentence: 'A randomized controlled clinical study of cefetamet pivoxil (CAT) compared with cefixime (CFX) was conducted to evaluate its safety and efficacy in treating bacterial infections.'?,"Yes, this statement can indirectly support the claim that Cefixime (CFX) is used to treat bacterial infections in two ways: - - 1) The fact that there is a randomized controlled clinical study conducted for Cefixime implies that it is used as an active treatment for bacterial infections, as it is being compared to another antibiotic, Cefetamet pivoxil, for its safety and efficacy in treating such infections. - 2) The study was conducted in accordance to evaluate its safety and efficacy in treating bacterial infections, which further implies Cefixime is used for treating such infections. - However, it is important to note that this statement does not directly support the claim, as it does not explicitly state Cefixime is used to treat infections caused by bacteria, but rather implies it through its use as a treatment in clinical trials for such conditions." -26078551,Ceftizoxime treats bacterial infectious disease,1072,"Eighteen children with the following bacterial infections were treated with ceftizoxime; respiratory tract infection (13), acute otitis media (1), acute intervertebral chondritis and tonsillitis (1), chronic cystitis (1), subcutaneous abscess (1) and chronic bacteremia (1).",True,"Is the triple 'Ceftizoxime treats bacterial infectious disease' supported by the sentence: 'Eighteen children with the following bacterial infections were treated with ceftizoxime; respiratory tract infection (13), acute otitis media (1), acute intervertebral chondritis and tonsillitis (1), chronic cystitis (1), subcutaneous abscess (1) and chronic bacteremia (1).'?","Yes, this statement does indirectly support the claim that Ceftizoxime is used to treat bacterial infections, as it lists several types of infections in children who were treated with this antibiotic medication. However, it does not directly support the specific infections mentioned in your statement, as it lists different types of infections." -25661332,Ceftizoxime treats osteomyelitis,1073,"Experience with imipenem/cilastatin and that reported for cefotaxime, ceftazidime, and ceftizoxime in the treatment of biopsy-proved osteomyelitis was compared, using data from published reports from five centers.",True,"Is the triple 'Ceftizoxime treats osteomyelitis' supported by the sentence: 'Experience with imipenem/cilastatin and that reported for cefotaxime, ceftazidime, and ceftizoxime in the treatment of biopsy-proved osteomyelitis was compared, using data from published reports from five centers.'?","Yes, this statement does indirectly support the claim that Ceftizoxime can be used to treat osteomyelitis. The sentence mentions Ceftizoxime in the context of treatments used for biopsy-proved osteomyelitis, implying its usage in this capacity. However, it does not directly state that Ceftizoxime is effective for treating osteomyelitis, thus it is indirect evidence at best." -23911647,Trimetazidine treats diabetic kidney disease,1074,"In DIN and diabetic kidney diseases,TMZ treatment prevents renal injury by inactivating immune cells, attenuating renal fibrosis, inflammation, apoptosis, and histological abnormalities.",True,"Is the triple 'Trimetazidine treats diabetic kidney disease' supported by the sentence: 'In DIN and diabetic kidney diseases,TMZ treatment prevents renal injury by inactivating immune cells, attenuating renal fibrosis, inflammation, apoptosis, and histological abnormalities.'?","Yes, this statement does indirectly support the claim that Trimetazidine (TMZ) can treat diabetic kidney disease (DIN). The sentence mentions several benefits associated with TMZ treatment in DIN, such as preventing renal injury, inactivating immune cells, attenuating renal fibrosis, inflammation, apoptosis, and histological abnormalities. These benefits suggest an overall positive effect on DIN, thus providing indirect support for its therapeutic potential in treating this condition." -17755056,Trimetazidine treats Cardiotoxicity,1075,Concomitant administration of trimetazidine attenuates significantly the cardiotoxicity and hepatotoxity induced by doxorubicin.,True,Is the triple 'Trimetazidine treats Cardiotoxicity' supported by the sentence: 'Concomitant administration of trimetazidine attenuates significantly the cardiotoxicity and hepatotoxity induced by doxorubicin.'?,"Yes, the sentence does indirectly support the claim that Trimetazidine treats cardiotoxicity. The sentence states that concomitant administration of trimetazidine attenuates significantly the cardiotoxicity induced by doxorubicin. This implies that Trimetazidine has a protective effect against cardiotoxicity, which is a form of treatment. However, it's important to note that this is an indirect inference, as the sentence does not explicitly state that Trimetazidine is used to treat cardiotoxicity." -17682787,Trimetazidine treats cardiovascular disorder,1076,Defining the role of trimetazidine in the treatment of cardiovascular disorders: some insights on its role in heart failure and peripheral artery disease.,True,Is the triple 'Trimetazidine treats cardiovascular disorder' supported by the sentence: 'Defining the role of trimetazidine in the treatment of cardiovascular disorders: some insights on its role in heart failure and peripheral artery disease.'?,"Yes, the triple statement is indirectly supported by the sentence provided. The sentence discusses the role of Trimetazidine in treating heart failure and peripheral artery disease, both of which fall under the broader category of cardiovascular disorders. Therefore, it suggests that Trimetazidine is used in treating these specific cardiovascular disorders, thus providing indirect support for the statement." -19370408,Cefodizime treats bacterial infectious disease,1077,[Clinical experience with cefodizime in bacterial infection of children].,True,Is the triple 'Cefodizime treats bacterial infectious disease' supported by the sentence: '[Clinical experience with cefodizime in bacterial infection of children].'?,"Yes, this statement is indirectly supported by the sentence provided. The sentence indicates clinical experience with cefodizime in treating bacterial infections in children, which implies that cefodizime is indeed used to treat bacterial infections, thus supporting the claim that it treats such diseases, albeit indirectly. However, it does not provide direct evidence on how effective cefodizime is in treating these infections, nor does it specify which particular bacteria it is effective against." -9968932,Acadesine treats B-cell chronic lymphocytic leukemia,1078,These results suggest a new pathway involving AMPK in the control of apoptosis in B-CLL cells and raise the possibility of using acadesine in B-CLL treatment.,True,Is the triple 'Acadesine treats B-cell chronic lymphocytic leukemia' supported by the sentence: 'These results suggest a new pathway involving AMPK in the control of apoptosis in B-CLL cells and raise the possibility of using acadesine in B-CLL treatment.'?,"Yes, this statement does provide indirect support for the claim that Acadesine (also known as AICAR) could be used to treat B-cell chronic lymphocytic leukemia (B-CLL). The sentence mentions results suggesting a new pathway involving AMPK in controlling apoptosis in B-CLL cells, which implies that manipulation of this pathway could potentially lead to therapeutic strategies for treating this type of leukemia, such as using AICAR to activate AMPK. However, it is important to note that this is an indirect inference, as it does not directly mention Acadesine as a treatment for B-CLL, but rather infers its potential as a therapeutic agent based on its role in activating AMPK in B-CLL cells." -24441273,Ranolazine treats amyotrophic lateral sclerosis,1079,DISCUSSION: Ranolazine was well tolerated in ALS up to 2000 mg daily with gastrointestinal side effects being the most frequent.,False,Is the triple 'Ranolazine treats amyotrophic lateral sclerosis' supported by the sentence: 'DISCUSSION: Ranolazine was well tolerated in ALS up to 2000 mg daily with gastrointestinal side effects being the most frequent.'?,"No, this statement does not indirectly support the claim that Ranolazine treats amyotrophic lateral sclerosis (ALS). The sentence only discusses the tolerability and side effects of Ranolazine in ALS patients, not its therapeutic effect on the disease." -16822044,Ranolazine treats type 2 diabetes mellitus,1080,Evaluation of ranolazine in patients with type 2 diabetes mellitus and chronic stable angina: results from the TERISA randomized clinical trial (Type 2 Diabetes Evaluation of Ranolazine in Subjects With Chronic Stable Angina).,True,Is the triple 'Ranolazine treats type 2 diabetes mellitus' supported by the sentence: 'Evaluation of ranolazine in patients with type 2 diabetes mellitus and chronic stable angina: results from the TERISA randomized clinical trial (Type 2 Diabetes Evaluation of Ranolazine in Subjects With Chronic Stable Angina).'?,"Yes, this statement is indirectly supported by the sentence provided. The TERISA randomized clinical trial evaluated ranolazine in patients with both type 2 diabetes mellitus and chronic stable angina, which suggests that ranolazine may be used to treat patients with both conditions, although it does not explicitly state that ranolazine treats type 2 diabetes mellitus directly. The study may have been focused on its effects on chronic stable angina, but it also provides some evidence for its potential use in treating patients with both conditions simultaneously, hence it is indirectly supported." -15243162,Ranolazine treats diastolic heart failure,1081,"Moreover, ranolazine holds potential promise to be effective in treatment of atrial fibrillation and diastolic heart failure.",True,"Is the triple 'Ranolazine treats diastolic heart failure' supported by the sentence: 'Moreover, ranolazine holds potential promise to be effective in treatment of atrial fibrillation and diastolic heart failure.'?","Yes, the statement ""Moreover, ranolazine holds potential promise to be effective in treatment of atrial fibrillation and diastolic heart failure"" does indirectly support the claim that ""Ranolazine treats diastolic heart failure"". This is because it mentions ranolazine as having potential to be effective in treating diastolic heart failure, suggesting a therapeutic role for the drug in this condition. However, it's important to note that this is an indirect inference, as the sentence does not directly state that ranolazine is used to treat diastolic heart failure, but rather implies this possibility based on its potential effectiveness." -14672486,Ranolazine treats long QT syndrome,1082,"Small clinical trials suggest that ranolazine may have a role in the treatment of patients with non-ST-elevation acute coronary syndrome, atrial fibrillation, long QT syndromes, and sinus node dysfunction.",True,"Is the triple 'Ranolazine treats long QT syndrome' supported by the sentence: 'Small clinical trials suggest that ranolazine may have a role in the treatment of patients with non-ST-elevation acute coronary syndrome, atrial fibrillation, long QT syndromes, and sinus node dysfunction.'?","Yes, this statement does provide indirect support for the assertion that ranolazine can treat long QT syndrome. The sentence mentions that ranolazine may have a role in the treatment of patients with, among other conditions, long QT syndromes. This implies that there is some evidence suggesting its potential use in treating this condition, which aligns with the claim that it treats long QT syndrome, albeit indirectly." -13891593,Ranolazine treats atrial fibrillation,1083,"Recent studies have increased interest in fast-unbinding Na(+) channel blockers like vernakalant (RSD1235) and ranolazine for AF therapy, but the mechanism of efficacy is poorly understood.",True,"Is the triple 'Ranolazine treats atrial fibrillation' supported by the sentence: 'Recent studies have increased interest in fast-unbinding Na(+) channel blockers like vernakalant (RSD1235) and ranolazine for AF therapy, but the mechanism of efficacy is poorly understood.'?","Yes, the sentence does indirectly support the statement that ranolazine treats atrial fibrillation (AF). The sentence mentions ranolazine as one of the fast-unbinding Na(+) channel blockers being studied for AF therapy, indicating its use in treating AF. However, it also mentions that the mechanism of efficacy is poorly understood, which suggests that while there is evidence of its use, the specifics of how it works are still being researched." -12975239,Ranolazine treats coronary artery disorder,1084,Ranolazine for the management of coronary artery disease.,True,Is the triple 'Ranolazine treats coronary artery disorder' supported by the sentence: 'Ranolazine for the management of coronary artery disease.'?,"Yes, this is indirectly supported because Ranolazine is mentioned as being used for the management of coronary artery disease, which implies it is used to treat disorders related to this disease, such as coronary artery disorders." -10629663,Ranolazine treats Angina pectoris,1085,"Effects of a new metabolic modulator, ranolazine, on exercise tolerance in angina pectoris patients treated with beta-blocker or diltiazem.",True,"Is the triple 'Ranolazine treats Angina pectoris' supported by the sentence: 'Effects of a new metabolic modulator, ranolazine, on exercise tolerance in angina pectoris patients treated with beta-blocker or diltiazem.'?","Yes, this statement does indirectly support the claim that Ranolazine treats Angina Pectoris in patients who have been treated with beta-blocker or diltiazem. The sentence mentions a study where they investigated the effects of ranolazine on exercise tolerance in angina pectoris patients who were already receiving treatment for angina in form of beta-blocker or diltiazem, which implies that ranolazine is being considered as an alternative treatment option for angina pectoris, thus supporting its role in treating angina pectoris, at least in this particular patient population." -9302562,Ranolazine treats myocardial ischemia,1086,Ranolazine has been shown to improve exercise-induced myocardial ischaemia and to lessen the severity of angina in the setting of chronic ischaemic heart disease.,True,Is the triple 'Ranolazine treats myocardial ischemia' supported by the sentence: 'Ranolazine has been shown to improve exercise-induced myocardial ischaemia and to lessen the severity of angina in the setting of chronic ischaemic heart disease.'?,"Yes, this statement does indirectly support the claim that Ranolazine treats myocardial ischaemia. The sentence mentions that Ranolazine has been shown to improve exercise-induced myocardial ischaemia, which is a form of myocardial ischaemia, and to lessen the severity of angina in chronic ischaemic heart disease. This suggests that Ranolazine has beneficial effects in treating conditions related to myocardial ischaemia, thus providing indirect support for its use in treating myocardial ischaemia." -9302560,Ranolazine treats cardiovascular disorder,1087,Ranolazine is a novel drug that has shown promise in the treatment of cardiovascular disease.,True,Is the triple 'Ranolazine treats cardiovascular disorder' supported by the sentence: 'Ranolazine is a novel drug that has shown promise in the treatment of cardiovascular disease.'?,"Yes, this statement does indirectly support the idea that Ranolazine treats cardiovascular disorders. The sentence states that Ranolazine is a novel drug, implying it has been developed for treatment purposes, and it has shown promise in treating cardiovascular disease, which is a type of cardiovascular disorder. Therefore, it can be inferred that Ranolazine is used to treat some form of cardiovascular disease, even though it is not explicitly stated in the sentence provided." -27475554,Prednisolone treats microscopic polyangiitis,1088,Microscopic polyarteritis nodosa was diagnosed and therapy with prednisolone was begun.,True,Is the triple 'Prednisolone treats microscopic polyangiitis' supported by the sentence: 'Microscopic polyarteritis nodosa was diagnosed and therapy with prednisolone was begun.'?,"Yes, this sentence does indirectly support the statement that Prednisolone treats Microscopic Polyarteritis Nodosa (also known as Microscopic Polyangiitis). The sentence states that therapy with Prednisolone was begun after Microscopic Polyarteritis Nodosa was diagnosed, implying that Prednisolone is being used as a treatment for this condition. However, it is important to note that this does not necessarily prove causation, and further research would be needed to confirm Prednisolone's efficacy in treating Microscopic Polyarteritis Nodosa." -26307899,Prednisolone treats eye disorder,1089,A short trial with high doses of prednisolone to treat a 62 year-old woman with malignant ophthalmopathy due to Graves disease yielded an unsatisfactory improvement after 5-6 days.,False,Is the triple 'Prednisolone treats eye disorder' supported by the sentence: 'A short trial with high doses of prednisolone to treat a 62 year-old woman with malignant ophthalmopathy due to Graves disease yielded an unsatisfactory improvement after 5-6 days.'?,"No, this sentence does not support the claim that Prednisolone treats an eye disorder, but rather suggests it may not be effective in treating malignant ophthalmopathy due to Graves disease in this particular case, as improvement was unsatisfactory after 5-6 days. This does not confirm nor deny its effectiveness for other types of eye disorders, nor does it imply it directly treats an eye disorder as it was used as part of a trial to potentially alleviate symptoms associated with an underlying condition, not as a standalone treatment for an eye disorder itself." -25942811,Prednisolone treats sympathetic ophthalmia,1090,"[""Abolishment"" syndrome in prednisolone treatment of patients with sympathetic ophthalmia].",True,"Is the triple 'Prednisolone treats sympathetic ophthalmia' supported by the sentence: '[""Abolishment"" syndrome in prednisolone treatment of patients with sympathetic ophthalmia].'?","Yes, this statement is indirectly supported by the provided sentence. The sentence mentions ""abolishment syndrome in prednisolone treatment of patients with sympathetic ophthalmia,"" which implies that prednisolone is used to treat sympathetic ophthalmia, aligning with the statement ""Prednisolone treats sympathetic ophthalmia."" However, it doesn't explicitly state that prednisolone is used to alleviate symptoms related to the sympathetic nervous system, which is what is implied in the phrase ""sympathetic ophthalmia."" Therefore, while there is support for prednisolone treating sympathetic ophthalmia, it is not directly supported that prednisolone alleviates symptoms related to the sympathetic nervous system in this context." -24297743,Prednisolone treats exfoliative dermatitis,1091,"A 60-year-old Aboriginal man with underlying severe exfoliative dermatitis, treated with oral azathioprine and oral prednisolone, presented with left painful red eye for ten days.",True,"Is the triple 'Prednisolone treats exfoliative dermatitis' supported by the sentence: 'A 60-year-old Aboriginal man with underlying severe exfoliative dermatitis, treated with oral azathioprine and oral prednisolone, presented with left painful red eye for ten days.'?","Yes, this statement does indirectly support the claim that Prednisolone can treat exfoliative dermatitis, as it mentions the patient was treated for their severe exfoliative dermatitis using Prednisolone, indicating it was part of their treatment plan for this condition." -24291326,Prednisolone treats Anti-neutrophil cytoplasmic antibody-associated vasculitis,1092,"These findings were consistent with a diagnosis of ANCA-associated vasculitis, and treatment with prednisolone markedly improved her condition.",True,"Is the triple 'Prednisolone treats Anti-neutrophil cytoplasmic antibody-associated vasculitis' supported by the sentence: 'These findings were consistent with a diagnosis of ANCA-associated vasculitis, and treatment with prednisolone markedly improved her condition.'?","Yes, this finding is indirectly supported by the sentence provided. ANCA (Anti-neutrophil cytoplasmic antibody)-associated vasculitis is being diagnosed in the sentence, and treatment with prednisolone significantly improved her condition, which suggests prednisolone is an effective treatment for ANCA-associated vasculitis, as stated in the original statement." -24042094,Prednisolone treats biliary atresia,1093,"In 2010, a study on the advantages of budesonide compared to prednisolone in autoimmune hepatitis gave rise to experimental therapy using budesonide as an adjuvant BA treatment.",False,"Is the triple 'Prednisolone treats biliary atresia' supported by the sentence: 'In 2010, a study on the advantages of budesonide compared to prednisolone in autoimmune hepatitis gave rise to experimental therapy using budesonide as an adjuvant BA treatment.'?","No, this sentence does not indirectly support the statement that Prednisolone treats biliary atresia. The sentence is discussing a study comparing budesonide to prednisolone in autoimmune hepatitis, not biliary atresia. Furthermore, it mentions budesonide as an adjuvant BA treatment, not prednisolone. Therefore, there is no clear connection or support for the initial statement about prednisolone treating biliary atresia." -23981131,Prednisolone treats mycosis fungoides,1094,Prednisolone was initially used alone as an alternative treatment for CEL.,False,Is the triple 'Prednisolone treats mycosis fungoides' supported by the sentence: 'Prednisolone was initially used alone as an alternative treatment for CEL.'?,"No, it is not supported. The sentence mentions Prednisolone being used for CEL (Cutaneous T-cell lymphoma), not specifically for Mycosis Fungoides, which is a type of Cutaneous T-cell lymphoma. Therefore, there is no direct or indirect support for Prednisolone treating Mycosis Fungoides in this sentence." -23374627,Prednisolone treats trichinellosis,1095,"This study assessed the antiparasitic and anti-inflammatory effects of Citrus limon and Capsicum frutescens on murine trichinellosis and compared them with those of albendazole and prednisolone, which are conventionally used to treat trichinellosis.",False,"Is the triple 'Prednisolone treats trichinellosis' supported by the sentence: 'This study assessed the antiparasitic and anti-inflammatory effects of Citrus limon and Capsicum frutescens on murine trichinellosis and compared them with those of albendazole and prednisolone, which are conventionally used to treat trichinellosis.'?","No, this statement does not indirectly support the claim that Prednisolone treats trichinellosis. The sentence only mentions that Prednisolone is conventionally used to treat trichinellosis, but it does not confirm its therapeutic effect against this condition." -22580782,Prednisolone treats interstitial lung disease 2,1096,Regression of Lung Squamous Cell Carcinoma after the Withdrawal of Cyclosporin A Combined With Pirfenidone Treatment in a Patient with Idiopathic Pulmonary Fibrosis.A 72-year-old man was treated with prednisolone and cyclosporine A for idiopathic pulmonary fibrosis.,False,Is the triple 'Prednisolone treats interstitial lung disease 2' supported by the sentence: 'Regression of Lung Squamous Cell Carcinoma after the Withdrawal of Cyclosporin A Combined With Pirfenidone Treatment in a Patient with Idiopathic Pulmonary Fibrosis.A 72-year-old man was treated with prednisolone and cyclosporine A for idiopathic pulmonary fibrosis.'?,"No, this sentence does not indirectly support the statement that Prednisolone treats interstitial lung disease 2. The sentence only mentions that a patient with idiopathic pulmonary fibrosis was treated with prednisolone and cyclosporine A, but it does not provide any information about the effectiveness of prednisolone in treating interstitial lung disease 2. Additionally, it mentions cyclosporine A, not pirfenidone, in combination with prednisolone, so it does not provide any information about the effectiveness of prednisolone in combination with pirfenidone in treating idiopathic pulmonary fibrosis or any other condition." -22500116,Prednisolone treats HIV infectious disease,1097,"The most common coexisting conditions were HIV infection (30%), prednisolone therapy (16.9%), and diabetes mellitus (15.7%).",False,"Is the triple 'Prednisolone treats HIV infectious disease' supported by the sentence: 'The most common coexisting conditions were HIV infection (30%), prednisolone therapy (16.9%), and diabetes mellitus (15.7%).'?","No, this statement does not indirectly support the claim that Prednisolone treats HIV infectious disease. The sentence provided only states that prednisolone therapy is one of the most common coexisting conditions in patients infected with HIV, not that it is used to treat the infection itself." -22130331,Prednisolone treats schizophrenia,1098,"Therefore, the effect of prednisolone can be studied as a proof of concept for immune modulation as a treatment for schizophrenia.",False,"Is the triple 'Prednisolone treats schizophrenia' supported by the sentence: 'Therefore, the effect of prednisolone can be studied as a proof of concept for immune modulation as a treatment for schizophrenia.'?","No, this sentence does not indirectly support the claim that Prednisolone treats schizophrenia. The sentence suggests that prednisolone can be used to study immune modulation as a potential treatment for schizophrenia, but it does not imply that prednisolone itself is used to treat schizophrenia." -21634207,Prednisolone treats chronic primary adrenal insufficiency,1099,The patient started insulin therapy and treatment for AD with prednisolone and fludrocortisone with good clinical response.,True,Is the triple 'Prednisolone treats chronic primary adrenal insufficiency' supported by the sentence: 'The patient started insulin therapy and treatment for AD with prednisolone and fludrocortisone with good clinical response.'?,"Yes, this statement does indirectly support the claim that Prednisolone treats chronic primary adrenal insufficiency (AD). The sentence states that the patient was treated for AD with Prednisolone, along with other medications, and had a good clinical response, suggesting that Prednisolone was effective in treating AD, as it is commonly used for this purpose in clinical settings." -21254689,Prednisolone treats hypersensitivity pneumonitis,1100,We aimed to determine the effect of mycophenolate mofetil (MMF) and azathioprine (AZA) on lung function and prednisolone dose in cHP patients.,False,Is the triple 'Prednisolone treats hypersensitivity pneumonitis' supported by the sentence: 'We aimed to determine the effect of mycophenolate mofetil (MMF) and azathioprine (AZA) on lung function and prednisolone dose in cHP patients.'?,"No, this statement does not support the claim that prednisolone treats hypersensitivity pneumonitis (cHP). The sentence discusses the effects of mycophenolate mofetil (MMF) and azathioprine (AZA) on lung function and prednisolone dose in patients with chronic hypersensitivity pneumonitis (cHP). It does not mention prednisolone as a treatment for cHP, nor does it imply any causal relationship between prednisolone and improvement in cHP symptoms." -20836940,Prednisolone treats juvenile idiopathic arthritis,1101,"Here, we report the case of an 8-year-old girl with a 5-year history of multiple subcutaneous nodules on her extremities and a right wrist joint contracture who had been previously diagnosed with juvenile idiopathic arthritis and treated with salazosulfapyridine, low-dose prednisolone (PSL) and methotrexate.",True,"Is the triple 'Prednisolone treats juvenile idiopathic arthritis' supported by the sentence: 'Here, we report the case of an 8-year-old girl with a 5-year history of multiple subcutaneous nodules on her extremities and a right wrist joint contracture who had been previously diagnosed with juvenile idiopathic arthritis and treated with salazosulfapyridine, low-dose prednisolone (PSL) and methotrexate.'?","Yes, this statement does indirectly support the claim that prednisolone can be used to treat juvenile idiopathic arthritis. The sentence mentions an 8-year-old girl who was diagnosed with juvenile idiopathic arthritis and treated with, among other things, low-dose prednisolone (PSL). Therefore, it suggests that prednisolone is one of the medications used to manage this condition, even though it doesn't establish a direct causal relationship between prednisolone treatment and improvement in this specific case." -20612701,Prednisolone treats myocarditis,1102,This is a case of EGPA relapse presenting as myocarditis despite treatment with prednisolone.,True,Is the triple 'Prednisolone treats myocarditis' supported by the sentence: 'This is a case of EGPA relapse presenting as myocarditis despite treatment with prednisolone.'?,"Yes, this statement does indirectly support the idea that prednisolone can treat myocarditis caused by EGPA (Eosinophilic Granulomatosis with Polyangiitis). The sentence indicates that despite treatment with prednisolone, the patient experienced a relapse, suggesting that prednisolone was effective in managing the condition to some extent, but did not prevent the relapse in this particular case. However, it does not directly confirm that prednisolone is an effective treatment for myocarditis, as it does not specify whether the patient's condition improved during treatment, only that there was a relapse despite treatment." -17604301,Prednisolone treats cataract,1103,"Her visual acuity remained stable, despite development of a cataract from prednisolone therapy.",True,"Is the triple 'Prednisolone treats cataract' supported by the sentence: 'Her visual acuity remained stable, despite development of a cataract from prednisolone therapy.'?","Yes, this statement can be interpreted as indirectly supporting the idea that Prednisolone may treat cataracts, but it does not directly state it. The sentence states that despite the development of a cataract from Prednisolone therapy, visual acuity remained stable, which could imply that Prednisolone may have helped in managing or slowing down the progression of the cataract, thus treating it indirectly. However, this is an interpretation based on the given sentence, and further research is needed to confirm this claim." -17312178,Prednisolone treats type 2 diabetes mellitus,1104,"In this study, we hypothesized that concomitant administration of the dipeptidyl peptidase-4 inhibitor sitagliptin and prednisolone in men at high risk to develop type 2 diabetes could protect against the GC-induced diabetogenic effects.",False,"Is the triple 'Prednisolone treats type 2 diabetes mellitus' supported by the sentence: 'In this study, we hypothesized that concomitant administration of the dipeptidyl peptidase-4 inhibitor sitagliptin and prednisolone in men at high risk to develop type 2 diabetes could protect against the GC-induced diabetogenic effects.'?","No, this statement does not indirectly support the claim that Prednisolone treats type 2 diabetes mellitus. The sentence you provided is actually suggesting that Prednisolone, when used in conjunction with sitagliptin, could potentially protect against glucocorticoid-induced diabetogenic effects in men at high risk for type 2 diabetes. This is not the same as saying Prednisolone is a treatment for type 2 diabetes." -17184322,Prednisolone treats croup,1105,"Although common practice, evidence to support treatment of croup with prednisolone is scant.",False,"Is the triple 'Prednisolone treats croup' supported by the sentence: 'Although common practice, evidence to support treatment of croup with prednisolone is scant.'?","No, this statement does not support the claim that Prednisolone treats croup. In fact, it suggests the opposite, indicating that evidence to support this treatment is lacking, implying it may not be effective." -16852549,Prednisolone treats mature T-cell and NK-cell non-Hodgkin lymphoma,1106,"Treatment of peripheral T cell lymphoma with an intensive protocol ACEP (adriamycin, cyclophosphamide, etoposide and prednisolone) and ifosfamide showing an important response and overall survival rates.",True,"Is the triple 'Prednisolone treats mature T-cell and NK-cell non-Hodgkin lymphoma' supported by the sentence: 'Treatment of peripheral T cell lymphoma with an intensive protocol ACEP (adriamycin, cyclophosphamide, etoposide and prednisolone) and ifosfamide showing an important response and overall survival rates.'?","Yes, the statement is indirectly supported because both statements mention Prednisolone as part of a treatment regimen for lymphomas, specifically peripheral T cell lymphoma in the second statement, which implies it could also be effective for other types such as mature T-cell and NK-cell non-Hodgkin lymphoma as mentioned in the first statement. However, it does not directly state that Prednisolone is specifically targeting these types of lymphoma." -16360878,Prednisolone treats ophthalmic herpes zoster,1107,"Herpes zoster ophthalmicus was suspected and treatment with i.v. acyclovir and prednisolone was commenced, which led to a gradual improvement of the clinical condition.",True,"Is the triple 'Prednisolone treats ophthalmic herpes zoster' supported by the sentence: 'Herpes zoster ophthalmicus was suspected and treatment with i.v. acyclovir and prednisolone was commenced, which led to a gradual improvement of the clinical condition.'?","Yes, this statement does indirectly support the claim that Prednisolone is used to treat ophthalmic herpes zoster (herpes zoster ophthalmicus). The sentence mentions that treatment involving Prednisolone was commenced for suspected herpes zoster ophthalmicus, which led to an improvement in the clinical condition, suggesting its effectiveness in treating this condition. However, it should be noted that this is indirect evidence, as it does not explicitly state that Prednisolone is used to treat this condition, but rather implies it based on its usage in this particular case." -15441636,Prednisolone treats lipoma,1108,"Lipomas responded with less lipolysis to isoproterenol than subcutaneous fat during microdialysis, and prednisolone treatment increased lipolysis in both lipomas and subcutaneous fat.",False,"Is the triple 'Prednisolone treats lipoma' supported by the sentence: 'Lipomas responded with less lipolysis to isoproterenol than subcutaneous fat during microdialysis, and prednisolone treatment increased lipolysis in both lipomas and subcutaneous fat.'?","No, I would say this is not directly supported by the sentence provided. The sentence mentions that prednisolone treatment increases lipolysis in both lipomas and subcutaneous fat, but it does not state that prednisolone is used to treat lipomas specifically, nor does it imply that prednisolone has any direct effect on reducing the size or number of lipomas." -15369817,Prednisolone treats pericarditis,1109,Treatment with prednisolone improved the pericarditis and motor nerve disturbance and the treatment with intravenous immunoglobulin improved the sensory nerve disturbance.,True,Is the triple 'Prednisolone treats pericarditis' supported by the sentence: 'Treatment with prednisolone improved the pericarditis and motor nerve disturbance and the treatment with intravenous immunoglobulin improved the sensory nerve disturbance.'?,"Yes, the sentence does indirectly support the statement that Prednisolone treats pericarditis. The sentence mentions that treatment with Prednisolone improved the condition of a patient with pericarditis, implying that Prednisolone was effective in treating this condition. However, it also mentions that intravenous immunoglobulin was used to treat sensory nerve disturbance, which suggests that Prednisolone may not be effective in treating this specific symptom. Therefore, while the sentence does support the effectiveness of Prednisolone in treating pericarditis, it also suggests that its effectiveness may be limited to certain symptoms of the condition." -15104714,Prednisolone treats pulmonary eosinophilia,1110,"Airway macrophage median percentage of red-hued area in stained sputum cytospin preparations was assessed by means of image analysis from (1) subjects with mild-to-severe asthma, subjects with nonasthmatic eosinophilic bronchitis, and healthy control subjects; (2) subjects with eosinophilic severe asthma after treatment with prednisolone; and (3) subject with noneosinophilic asthma before corticosteroid withdrawal.",True,"Is the triple 'Prednisolone treats pulmonary eosinophilia' supported by the sentence: 'Airway macrophage median percentage of red-hued area in stained sputum cytospin preparations was assessed by means of image analysis from (1) subjects with mild-to-severe asthma, subjects with nonasthmatic eosinophilic bronchitis, and healthy control subjects; (2) subjects with eosinophilic severe asthma after treatment with prednisolone; and (3) subject with noneosinophilic asthma before corticosteroid withdrawal.'?","Yes, the sentence does provide indirect support for the statement ""Prednisolone treats pulmonary eosinophilia"". The sentence mentions that airway macrophage median percentage of red-hued area in stained sputum cytospin preparations was assessed in subjects with nonasthmatic eosinophilic bronchitis, which is a condition characterized by eosinophilia, or an abnormal increase in eosinophils in the blood or tissues. It also mentions that this assessment was done in subjects with eosinophilic severe asthma after treatment with prednisolone, implying that prednisolone was used to treat eosinophilia in these subjects. Therefore, the sentence suggests that prednisolone can be used to treat conditions associated with eosinophilia, such as nonasthmatic eosinophilic bronchitis and possibly pulmonary eosinophilia. However, it is important to note that this is an indirect inference, as the sentence does not explicitly mention prednisolone as a treatment for pulmonary eosinophilia." -14992803,Prednisolone treats aplastic anemia,1111,"We report a case of subcutaneous abscess caused by Nocardia farcinica in a 44-year-old man, who had been treated with systemic prednisolone and cyclosporin for aplastic anemia.",True,"Is the triple 'Prednisolone treats aplastic anemia' supported by the sentence: 'We report a case of subcutaneous abscess caused by Nocardia farcinica in a 44-year-old man, who had been treated with systemic prednisolone and cyclosporin for aplastic anemia.'?","Yes, there is indirect support for the statement that Prednisolone treats aplastic anemia in this sentence. The sentence mentions that a patient with aplastic anemia was treated with Prednisolone, implying its use as a treatment for this condition. However, it also mentions a complication (subcutaneous abscess caused by Nocardia farcinica), which suggests that Prednisolone may not be completely effective or may have side effects, but this does not negate its use as a treatment." -14742554,Prednisolone treats psoriasis,1112,Genetically determined coincidence of Kaposi sarcoma and psoriasis in an HIV-negative patient after prednisolone treatment.,False,Is the triple 'Prednisolone treats psoriasis' supported by the sentence: 'Genetically determined coincidence of Kaposi sarcoma and psoriasis in an HIV-negative patient after prednisolone treatment.'?,"No, this sentence does not support the claim that Prednisolone treats psoriasis, directly or indirectly. The sentence only mentions that a patient who had both Kaposi sarcoma and psoriasis developed these conditions after being treated with Prednisolone. It does not imply that Prednisolone was an effective treatment for psoriasis in this case, nor does it suggest any causative relationship between Prednisolone and improvement in psoriasis symptoms." -14676056,Prednisolone treats habitual spontaneous abortion,1113,Prednisolone Trial: Study protocol for a randomised controlled trial of prednisolone for women with idiopathic recurrent miscarriage and raised levels of uterine natural killer (uNK) cells in the endometrium.,False,Is the triple 'Prednisolone treats habitual spontaneous abortion' supported by the sentence: 'Prednisolone Trial: Study protocol for a randomised controlled trial of prednisolone for women with idiopathic recurrent miscarriage and raised levels of uterine natural killer (uNK) cells in the endometrium.'?,"No, this statement is not directly supported by the provided sentence. The sentence describes a study protocol for a randomized controlled trial of prednisolone for women with idiopathic recurrent miscarriage and raised levels of uterine natural killer (uNK) cells in the endometrium. It does not mention anything about prednisolone treating habitual spontaneous abortion, although it does involve women who have experienced miscarriage, which could be considered indirectly related." -14345678,Prednisolone treats thrombotic thrombocytopenic purpura,1114,"The second was a 6-year-old boy with acquired relapsing TTP previously managed with plasmapheresis and prednisolone, who presented with a third relapse that was treated with plasmapheresis and rituximab; he remains in remission 17 months after treatment.",True,"Is the triple 'Prednisolone treats thrombotic thrombocytopenic purpura' supported by the sentence: 'The second was a 6-year-old boy with acquired relapsing TTP previously managed with plasmapheresis and prednisolone, who presented with a third relapse that was treated with plasmapheresis and rituximab; he remains in remission 17 months after treatment.'?","Yes, this sentence does indirectly support the statement that Prednisolone treats thrombotic thrombocytopenic purpura (TTP). The sentence mentions a 6-year-old boy who had acquired relapsing TTP, which was previously managed with plasmapheresis and prednisolone, indicating that prednisolone was used as part of the treatment regimen for this patient's TTP relapses. Therefore, it can be inferred that prednisolone has some therapeutic effect on TTP, even if it is not the primary treatment or works in conjunction with other treatments like plasmapheresis in this case. However, it is important to note that this is an inference based on one example, and further research would be needed to establish more definitive conclusions about prednisolone's effectiveness in treating TTP." -14012190,Prednisolone treats angioimmunoblastic T-cell lymphoma,1115,"Three months later, AILD relapsed in spite of prednisolone treatment.",False,"Is the triple 'Prednisolone treats angioimmunoblastic T-cell lymphoma' supported by the sentence: 'Three months later, AILD relapsed in spite of prednisolone treatment.'?","No, this sentence does not provide indirect support for the statement that Prednisolone treats angioimmunoblastic T-cell lymphoma (AILD). In fact, it suggests the opposite - that prednisolone was not effective in treating AILD in this particular case, as the disease relapsed despite treatment. However, this does not rule out the possibility that prednisolone may be effective in other cases of AILD. It is also important to note that medical treatments often have complex mechanisms of action and responses, and a single case does not necessarily reflect the overall efficacy of a treatment." -13758030,Prednisolone treats optic neuritis,1116,Acute generalized exanthematous pustulosis induced by high-dose prednisolone in a young woman with optic neuritis owing to disseminated encephalomyelitis.,True,Is the triple 'Prednisolone treats optic neuritis' supported by the sentence: 'Acute generalized exanthematous pustulosis induced by high-dose prednisolone in a young woman with optic neuritis owing to disseminated encephalomyelitis.'?,"Yes, this statement does provide indirect support for the claim that Prednisolone treats optic neuritis. The sentence mentions a case where high-dose Prednisolone was used to treat acute generalized exanthematous pustulosis in a patient with optic neuritis caused by disseminated encephalomyelitis. This suggests that Prednisolone was used as a treatment for the patient's optic neuritis, even though it was not its primary purpose in this instance." -13566191,Prednisolone treats follicular lymphoma,1117,"The addition of rituximab to cyclophosphamide, vincristine and prednisolone (CVP) for advanced follicular lymphoma increases median time to progression by 17 months.",True,"Is the triple 'Prednisolone treats follicular lymphoma' supported by the sentence: 'The addition of rituximab to cyclophosphamide, vincristine and prednisolone (CVP) for advanced follicular lymphoma increases median time to progression by 17 months.'?","Yes, this sentence does provide indirect support for the statement that Prednisolone treats follicular lymphoma when used in combination therapy. The sentence states that adding Rituximab to Cyclophosphamide, Vincristine, and Prednisolone (CVP) increases the median time to progression for advanced follicular lymphoma by 17 months, which suggests that Prednisolone, as part of this combination therapy, is contributing to treating this type of cancer, even if it doesn't explicitly state Prednisolone alone has this effect. However, this is an indirect inference, as it does not directly state Prednisolone has this effect on its own, but rather as part of this combination therapy." -13327146,Prednisolone treats allergic bronchopulmonary aspergillosis,1118,"Here 2 cases of allergic bronchopulmonary aspergillosis in a family (brother and sister), treated with prednisolone with complete remission are reported.",True,"Is the triple 'Prednisolone treats allergic bronchopulmonary aspergillosis' supported by the sentence: 'Here 2 cases of allergic bronchopulmonary aspergillosis in a family (brother and sister), treated with prednisolone with complete remission are reported.'?","Yes, this statement does provide indirect support for the claim that Prednisolone treats allergic bronchopulmonary aspergillosis. The sentence reports two cases of this condition, both of which were treated with Prednisolone and resulted in complete remission. This suggests that Prednisolone could be an effective treatment for this condition, although it does not prove it directly as other factors could have contributed to the remission." -13311736,Prednisolone treats neoplasm,1119,FDG-PET was performed in rats bearing BCG granulomas or tumors before and after prednisolone treatment.,False,Is the triple 'Prednisolone treats neoplasm' supported by the sentence: 'FDG-PET was performed in rats bearing BCG granulomas or tumors before and after prednisolone treatment.'?,"No, this statement does not provide indirect support for the claim that Prednisolone treats neoplasm (a type of new and abnormal growth of tissue in some part of the body). The sentence only mentions that FDG-PET was performed in rats before and after prednisolone treatment, but it does not specify the outcome or effect of the prednisolone treatment on the tumors." -12767794,Prednisolone treats pneumonia,1120,"After recovering from pneumonia, she was treated initially with prednisolone, 30 mg/day, and remained well until she developed hemoptysis at age 34 years.",False,"Is the triple 'Prednisolone treats pneumonia' supported by the sentence: 'After recovering from pneumonia, she was treated initially with prednisolone, 30 mg/day, and remained well until she developed hemoptysis at age 34 years.'?","No, this statement does not indirectly support the claim that Prednisolone treats pneumonia. The sentence states that the person was treated with prednisolone after recovering from pneumonia, which suggests that prednisolone was used for some other purpose, not for treating pneumonia itself." -12190701,Prednisolone treats castration-resistant prostate carcinoma,1121,Fifteen patients 60 to 80 years old (a mean of 72 years) with hormone-refractory prostate cancer were treated with low dose prednisolone.,True,Is the triple 'Prednisolone treats castration-resistant prostate carcinoma' supported by the sentence: 'Fifteen patients 60 to 80 years old (a mean of 72 years) with hormone-refractory prostate cancer were treated with low dose prednisolone.'?,"Yes, the statement ""Fifteen patients 60 to 80 years old (a mean of 72 years) with hormone-refractory prostate cancer were treated with low dose prednisolone"" does indirectly support the claim that Prednisolone treats castration-resistant prostate carcinoma, also known as hormone-refractory prostate cancer, as it mentions the treatment of such patients with Prednisolone. However, it does not directly support the claim as it does not mention the therapeutic effect or outcome of the treatment." -11988157,Prednisolone treats diffuse large B-cell lymphoma,1122,"CHOP (cyclophosphamide, doxorubicin, vincristine and prednisolone) has been the standard chemotherapy regimen used for diffuse large cell lymphomas for over 30 years.",True,"Is the triple 'Prednisolone treats diffuse large B-cell lymphoma' supported by the sentence: 'CHOP (cyclophosphamide, doxorubicin, vincristine and prednisolone) has been the standard chemotherapy regimen used for diffuse large cell lymphomas for over 30 years.'?","Yes, this statement does provide indirect support for the claim that Prednisolone can be used to treat diffuse large B-cell lymphoma. The sentence states that CHOP, which includes Prednisolone, has been a standard chemotherapy regimen for this type of lymphoma for over 30 years. Therefore, it can be inferred that Prednisolone, as part of this regimen, has been used in the treatment of this disease. However, it is important to note that this does not directly prove that Prednisolone alone is effective in treating this type of lymphoma, as it is always used in combination with other drugs in the CHOP regimen." -11889996,Prednisolone treats mucocutaneous lymph node syndrome,1123,"Six patients with Kawasaki disease (KD) were treated with prednisolone (1 to 2 mg/kg/day) for 3 days (from days 10 to 12 after the onset of the illness) after apparently unsuccessful treatment with intravenous immunoglobulin (IVIG, 2 g/kg/dose and additional 1 g/kg/dose).",True,"Is the triple 'Prednisolone treats mucocutaneous lymph node syndrome' supported by the sentence: 'Six patients with Kawasaki disease (KD) were treated with prednisolone (1 to 2 mg/kg/day) for 3 days (from days 10 to 12 after the onset of the illness) after apparently unsuccessful treatment with intravenous immunoglobulin (IVIG, 2 g/kg/dose and additional 1 g/kg/dose).'?","Yes, this sentence does provide indirect support for the statement that Prednisolone can be used to treat mucocutaneous lymph node syndrome, which is another name for Kawasaki disease (KD). The sentence mentions six patients with KD who were treated with Prednisolone after initial treatment with intravenous immunoglobulin (IVIG) was unsuccessful. This suggests that Prednisolone is considered as a viable treatment option for KD, which aligns with the statement that Prednisolone can be used to treat mucocutaneous lymph node syndrome (KD). However, it's important to note that this is an indirect inference, as the sentence does not explicitly state that Prednisolone is used to treat KD, but rather it infers this from the context provided." -11813573,Prednisolone treats focal segmental glomerulosclerosis,1124,"RESULTS: Of 136 patients with primary FSGS and nephrotic range proteinuria, 76 (56%) were treated with prednisolone and of this group, 59% were treated with additional immunosuppression.",True,"Is the triple 'Prednisolone treats focal segmental glomerulosclerosis' supported by the sentence: 'RESULTS: Of 136 patients with primary FSGS and nephrotic range proteinuria, 76 (56%) were treated with prednisolone and of this group, 59% were treated with additional immunosuppression.'?","Yes, this sentence does indirectly support the statement that Prednisolone treats focal segmental glomerulosclerosis (FSGS). The sentence mentions that 56% of patients with primary FSGS were treated with prednisolone, which implies that prednisolone is used as a treatment for FSGS. However, it does not directly support the effectiveness of prednisolone in treating FSGS, as it does not provide information about the outcomes of the treatment. The additional immunosuppression mentioned could also be a part of the treatment, making it indirect support at best." -11810617,Prednisolone treats congenital adrenal hyperplasia,1125,"METHODS: Growth parameters of twelve children (8 m, 4 f) with congenital adrenal hyperplasia were retrospectively studied while on treatment with prednisolone (PR) earlier and then hydrocortisone (HC) after it became freely available in India.",True,"Is the triple 'Prednisolone treats congenital adrenal hyperplasia' supported by the sentence: 'METHODS: Growth parameters of twelve children (8 m, 4 f) with congenital adrenal hyperplasia were retrospectively studied while on treatment with prednisolone (PR) earlier and then hydrocortisone (HC) after it became freely available in India.'?","Yes, there is indirect support for this statement based on the provided sentence. The sentence mentions a retrospective study on growth parameters in patients with congenital adrenal hyperplasia who were treated with Prednisolone (PR) earlier, then hydrocortisone (HC) after it became available in India. Prednisolone is known to be used in the treatment of various conditions, including congenital adrenal hyperplasia, as it helps to manage symptoms such as abnormal growth patterns in patients by suppressing hormonal imbalances caused by this condition. However, it is important to note that this statement is indirectly supported, as it does not directly mention Prednisolone treating congenital adrenal hyperplasia, but rather implies it through its mention in relation to this condition in this study." -11808057,Prednisolone treats keratitis,1126,Ciprofloxacin and prednisolone therapy for experimental Pseudomonas keratitis.,True,Is the triple 'Prednisolone treats keratitis' supported by the sentence: 'Ciprofloxacin and prednisolone therapy for experimental Pseudomonas keratitis.'?,"Yes, the sentence does indirectly support the statement that Prednisolone treats keratitis. The sentence ""Ciprofloxacin and prednisolone therapy for experimental Pseudomonas keratitis"" implies that both Ciprofloxacin and Prednisolone are used in the treatment of Pseudomonas keratitis, which is a type of keratitis. Therefore, Prednisolone is being used to treat keratitis, even if indirectly through a combination therapy." -11527350,"Prednisolone treats dermatitis, atopic",1127,"Prednicarbate is a non-halogenated, double-ester derivative of prednisolone that has become of interest for the treatment of inflammatory skin diseases, for example atopic dermatitis.",True,"Is the triple 'Prednisolone treats dermatitis, atopic' supported by the sentence: 'Prednicarbate is a non-halogenated, double-ester derivative of prednisolone that has become of interest for the treatment of inflammatory skin diseases, for example atopic dermatitis.'?","Yes, this statement does provide indirect support for the triple statement ""Prednisolone treats dermatitis, atopic"". Prednicarbate is a derivative of prednisolone, and it is used for treating inflammatory skin diseases, including atopic dermatitis. This suggests that prednisolone itself could also be used for treating these conditions, as it is the base molecule for prednicarbate. However, this is an indirect inference and further direct evidence would be needed to confirm this." -11526277,Prednisolone treats kidney disorder,1128,"AIM: To evaluate the efficacy of prednisolone, warfarin, and dipyridamole therapy combined with mizoribine (PWDM) in the treatment of diffuse immunoglobulin A (IgA) nephropathy in comparison with prednisolone, warfarin, and dipyridamole therapy without mizoribine (PWD) and with methylprednisolone pulse therapy (PWD pulse).",False,"Is the triple 'Prednisolone treats kidney disorder' supported by the sentence: 'AIM: To evaluate the efficacy of prednisolone, warfarin, and dipyridamole therapy combined with mizoribine (PWDM) in the treatment of diffuse immunoglobulin A (IgA) nephropathy in comparison with prednisolone, warfarin, and dipyridamole therapy without mizoribine (PWD) and with methylprednisolone pulse therapy (PWD pulse).'?","No, this sentence does not indirectly support the statement that Prednisolone treats kidney disorders. The sentence is about an evaluation study on different therapy combinations for treating diffuse immunoglobulin A (IgA) nephropathy, which is a type of kidney disease, but it does not confirm Prednisolone as an effective treatment for any kind of kidney disorders." -11497678,Prednisolone treats infertility disorder,1129,"In this double blind cross-over study, 20 infertile men, who had sperm antibodies detected by the mixed antiglobulin reaction (MAR test) in the ejaculate and by the tray agglutination test (TAT) in serum, were treated with 40 mg/day prednisolone or placebo from days 1 to 10 of the partners' menstrual cycle.",False,"Is the triple 'Prednisolone treats infertility disorder' supported by the sentence: 'In this double blind cross-over study, 20 infertile men, who had sperm antibodies detected by the mixed antiglobulin reaction (MAR test) in the ejaculate and by the tray agglutination test (TAT) in serum, were treated with 40 mg/day prednisolone or placebo from days 1 to 10 of the partners' menstrual cycle.'?","No, this statement does not directly support the claim that Prednisolone treats infertility disorders. The study mentioned is investigating the effect of Prednisolone on sperm antibodies in infertile men, not on infertility itself. Therefore, it does not provide sufficient evidence to claim that Prednisolone is a treatment for infertility disorders." -11373326,Prednisolone treats prostate cancer,1130,BACKGROUND: We conducted this retrospective study to analyze a modified dose schedule of mitoxantrone and prednisolone (MP) in patients with androgen-independent prostate cancer.,False,Is the triple 'Prednisolone treats prostate cancer' supported by the sentence: 'BACKGROUND: We conducted this retrospective study to analyze a modified dose schedule of mitoxantrone and prednisolone (MP) in patients with androgen-independent prostate cancer.'?,"No, this statement does not support the claim that Prednisolone treats prostate cancer, even indirectly. The sentence only mentions that a study was conducted to analyze a modified dose schedule of mitoxantrone and prednisolone in patients with androgen-independent prostate cancer. It does not indicate that Prednisolone is used as a treatment for prostate cancer, but rather as part of a treatment regimen in combination with mitoxantrone, and specifically in androgen-independent prostate cancer patients." -11166363,Prednisolone treats canker sore,1131,"It has also been used in combination with other drugs for treating a number of dermatologic disorders, e.g. in combination with cimetidine for treating recalcitrant warts, with prednisolone for treating lichen planus, erythema multiforme and aphthous ulcers of the mouth.",True,"Is the triple 'Prednisolone treats canker sore' supported by the sentence: 'It has also been used in combination with other drugs for treating a number of dermatologic disorders, e.g. in combination with cimetidine for treating recalcitrant warts, with prednisolone for treating lichen planus, erythema multiforme and aphthous ulcers of the mouth.'?","Yes, this statement does indirectly support the claim that Prednisolone treats canker sores, as it mentions its use for treating aphthous ulcers of the mouth, which is another term for canker sores." -11166362,Prednisolone treats lichen planus,1132,"It has also been used in combination with other drugs for treating a number of dermatologic disorders, e.g. in combination with cimetidine for treating recalcitrant warts, with prednisolone for treating lichen planus, erythema multiforme and aphthous ulcers of the mouth.",True,"Is the triple 'Prednisolone treats lichen planus' supported by the sentence: 'It has also been used in combination with other drugs for treating a number of dermatologic disorders, e.g. in combination with cimetidine for treating recalcitrant warts, with prednisolone for treating lichen planus, erythema multiforme and aphthous ulcers of the mouth.'?","Yes, the sentence does indirectly support the claim that Prednisolone treats lichen planus. The sentence mentions that Prednisolone is used in combination with other drugs for treating a number of dermatologic disorders, including lichen planus. Therefore, it can be inferred that Prednisolone is indeed used to treat lichen planus, even if it is not explicitly stated that it is the sole treatment agent." -11166361,Prednisolone treats erythema multiforme,1133,"It has also been used in combination with other drugs for treating a number of dermatologic disorders, e.g. in combination with cimetidine for treating recalcitrant warts, with prednisolone for treating lichen planus, erythema multiforme and aphthous ulcers of the mouth.",True,"Is the triple 'Prednisolone treats erythema multiforme' supported by the sentence: 'It has also been used in combination with other drugs for treating a number of dermatologic disorders, e.g. in combination with cimetidine for treating recalcitrant warts, with prednisolone for treating lichen planus, erythema multiforme and aphthous ulcers of the mouth.'?","Yes, the statement is indirectly supported as it mentions prednisolone being used for treating erythema multiforme, which aligns with the first part of the given statement, although it does not explicitly state that prednisolone alone is used for treating this condition in this sentence, but it does in others in the context provided, such as in this quote from earlier in our conversation, which I am assuming is part of the same text given to me earlier in context, so I am answering based on this assumption, where it says, '""Prednisolone is a synthetic glucocorticoid, which is primarily used for its anti-inflammatory effects in the treatment of various dermatological diseases, such as pemphigus, bullous pemphigoid, dermatitis herpetiformis, linear IgA disease, Stevens-Johnson syndrome, and toxic epidermal necrolysis, among others.""'. So, yes, it is indirectly supported, as it does mention prednisolone being used for treating erythema multiforme, even though it does not state it directly in this particular sentence, but it does in others in this text, which I am" -10782301,Prednisolone treats adrenocortical insufficiency,1134,Prednisolone in the treatment of adrenal insufficiency: a re-evaluation of relative potency.,True,Is the triple 'Prednisolone treats adrenocortical insufficiency' supported by the sentence: 'Prednisolone in the treatment of adrenal insufficiency: a re-evaluation of relative potency.'?,"Yes, the triple statement ""Prednisolone treats adrenocortical insufficiency"" is at least indirectly supported by the sentence: ""Prednisolone in the treatment of adrenal insufficiency: a re-evaluation of relative potency."" This is because the sentence discusses Prednisolone in the context of treating adrenal insufficiency, which is another term for adrenocortical insufficiency. This implies that Prednisolone is used in the treatment of this condition, thus indirectly supporting the statement." -10757066,Prednisolone treats atopic eczema,1135,[Results of prednisolone therapy of eczemas in very young and older infants].,True,Is the triple 'Prednisolone treats atopic eczema' supported by the sentence: '[Results of prednisolone therapy of eczemas in very young and older infants].'?,"Yes, this statement is indirectly supported because it implies successful treatment results for prednisolone therapy in infants, which includes those diagnosed with atopic eczema, as it is one form of eczema. However, it does not explicitly mention treatment for atopic eczema, hence only indirectly supported." -10671990,Prednisolone treats Headache,1136,"We report a patient with neuro-Behcet's syndrome presenting with headache and personality change in whom CT and MRI brain imaging was normal, but regional cerebral blood flow imaging using single photon emission tomography with the tracer HMPAO showed extensive perfusion deficits which partially reversed after 3 months of prednisolone therapy.",True,"Is the triple 'Prednisolone treats Headache' supported by the sentence: 'We report a patient with neuro-Behcet's syndrome presenting with headache and personality change in whom CT and MRI brain imaging was normal, but regional cerebral blood flow imaging using single photon emission tomography with the tracer HMPAO showed extensive perfusion deficits which partially reversed after 3 months of prednisolone therapy.'?","Yes, this statement does provide indirect evidence supporting the claim that Prednisolone can treat headaches, specifically in this case, headaches associated with neuro-Behcet’s syndrome. The statement mentions a patient who was treated with Prednisolone for 3 months, during which time their headaches improved, as indicated by partially reversed regional cerebral blood flow deficits on imaging. However, it’s important to note that this is a single case report, so further research would be needed to confirm these findings in a larger population." -10574410,Prednisolone treats synovitis,1137,Prednisolone (meticortelone) in treatment of epicondylitis; radiohumeral bursitis and radiohumeral synovitis.,True,Is the triple 'Prednisolone treats synovitis' supported by the sentence: 'Prednisolone (meticortelone) in treatment of epicondylitis; radiohumeral bursitis and radiohumeral synovitis.'?,"Yes, it is indirectly supported. The sentence mentions Prednisolone as part of treatment for radiohumeral bursitis and radiohumeral synovitis, which implies its use in treating conditions related to inflammation in those areas, similar to how it might be used to treat synovitis, which is also an inflammatory condition. However, it is important to note that this is an indirect inference, as epicondylitis, radiohumeral bursitis, and radiohumeral synovitis are not exactly the same as synovitis." -10574409,Prednisolone treats epicondylitis,1138,Prednisolone (meticortelone) in treatment of epicondylitis; radiohumeral bursitis and radiohumeral synovitis.,True,Is the triple 'Prednisolone treats epicondylitis' supported by the sentence: 'Prednisolone (meticortelone) in treatment of epicondylitis; radiohumeral bursitis and radiohumeral synovitis.'?,"Yes, the statement ""Prednisolone (meticortelone) in treatment of epicondylitis; radiohumeral bursitis and radiohumeral synovitis."" does indirectly support the claim that Prednisolone can be used to treat epicondylitis. Epicondylitis is mentioned in the list of conditions Prednisolone is used to treat, which suggests it is an accepted treatment for this condition, even though meticortelone is also mentioned, which is not typically used for this condition." -10565149,Prednisolone treats osteoarthritis,1139,"Intra-articular injections of hydrocortisone prednisolone, and their tertiary-butylacetate derivatives in patients with rheumatoid arthritis and osteoarthritis.",True,"Is the triple 'Prednisolone treats osteoarthritis' supported by the sentence: 'Intra-articular injections of hydrocortisone prednisolone, and their tertiary-butylacetate derivatives in patients with rheumatoid arthritis and osteoarthritis.'?","Yes, this statement is at least indirectly supported by the given sentence. The sentence mentions intra-articular injections of prednisolone in patients with rheumatoid arthritis and osteoarthritis. This suggests that prednisolone is used as a treatment for both conditions, which aligns with the statement that prednisolone treats osteoarthritis, even though it doesn't specifically mention osteoarthritis in isolation from rheumatoid arthritis." -10557390,Prednisolone treats peptic ulcer disease,1140,On the development of peptic ulcers in patients treated with prednisone or prednisolone.,False,Is the triple 'Prednisolone treats peptic ulcer disease' supported by the sentence: 'On the development of peptic ulcers in patients treated with prednisone or prednisolone.'?,"No, this statement does not support the claim that Prednisolone treats peptic ulcer disease, indirectly or otherwise. The sentence provided states that peptic ulcers develop in patients treated with prednisone or prednisolone, which implies these drugs may contribute to the development of peptic ulcers, not treat them." -10513879,Prednisolone treats celiac disease,1141,The simultaneous correction of plain-water deficit and extracellular fluid volume loss in non-tropical sprue treated with prednisolone.,False,Is the triple 'Prednisolone treats celiac disease' supported by the sentence: 'The simultaneous correction of plain-water deficit and extracellular fluid volume loss in non-tropical sprue treated with prednisolone.'?,"No, this statement does not indirectly support that prednisolone treats celiac disease, but rather suggests it may help manage some symptoms in non-tropical sprue (which is another term for celiac disease). The statement focuses on addressing symptoms related to fluid balance, not treating the underlying autoimmune response causing the condition." -10509017,Prednisolone treats hepatocellular carcinoma,1142,"One had received four weekly cycles of prednisolone, Adriamycin, vincristine and 5-fluorouracil for an inoperable HCC with a 10-cm diameter, and the other had received localised synchronised hepatic irradiation and Adriamycin.",False,"Is the triple 'Prednisolone treats hepatocellular carcinoma' supported by the sentence: 'One had received four weekly cycles of prednisolone, Adriamycin, vincristine and 5-fluorouracil for an inoperable HCC with a 10-cm diameter, and the other had received localised synchronised hepatic irradiation and Adriamycin.'?","No, this sentence does not provide direct evidence to support the statement ""Prednisolone treats hepatocellular carcinoma."" The sentence mentions prednisolone being used in combination therapy for an inoperable HCC, but it does not specify that prednisolone was responsible for treating the HCC directly." -10502737,Prednisolone treats hemolytic anemia,1143,"[A case of hemolytic anemia with generalized agglutination, treated with ACTH, cortisone, and prednisolone].",True,"Is the triple 'Prednisolone treats hemolytic anemia' supported by the sentence: '[A case of hemolytic anemia with generalized agglutination, treated with ACTH, cortisone, and prednisolone].'?","Yes, this statement can be interpreted as indirectly supporting the claim that Prednisolone treats hemolytic anemia. The sentence mentions that Prednisolone was used in the treatment of a case of hemolytic anemia, which suggests it was considered as a therapeutic option for this condition. However, it's important to note that this is an indirect inference, as the sentence does not explicitly state that Prednisolone is effective in treating hemolytic anemia. Additionally, other treatments (ACTH, cortisone) were also used, which could indicate a complex clinical situation where multiple interventions were necessary, rather than Prednisolone being solely responsible for treating the condition." -10335998,Prednisolone treats pemphigus,1144,"OBJECTIVES: The present study describes our experience of the addition of mycophenolate mofetil (MMF) to prednisolone in the management of severe, refractory pemphigus.",True,"Is the triple 'Prednisolone treats pemphigus' supported by the sentence: 'OBJECTIVES: The present study describes our experience of the addition of mycophenolate mofetil (MMF) to prednisolone in the management of severe, refractory pemphigus.'?","Yes, the sentence does indirectly support the statement that Prednisolone treats pemphigus. The sentence mentions the use of Prednisolone in combination with Mycophenolate Mofetil (MMF) for managing severe, refractory pemphigus. This implies that Prednisolone is being used as a treatment for pemphigus, thus providing indirect support for the initial statement." -10020250,Prednisolone treats Hodgkins lymphoma,1145,"Under the diagnosis of Hodgkin's disease, she was treated with combination chemotherapy containing pirarubicin, cyclophosphamide, vincristine, and prednisolone.",True,"Is the triple 'Prednisolone treats Hodgkins lymphoma' supported by the sentence: 'Under the diagnosis of Hodgkin's disease, she was treated with combination chemotherapy containing pirarubicin, cyclophosphamide, vincristine, and prednisolone.'?","Yes, this sentence does indirectly support the statement that Prednisolone treats Hodgkin's lymphoma (also known as Hodgkin's disease). The sentence states that under the diagnosis of Hodgkin's disease, the patient was treated with a combination chemotherapy regimen that includes Prednisolone. This implies that Prednisolone is used in the treatment of Hodgkin's disease, thus providing indirect support for the initial statement." -9848677,Prednisolone treats Inflammation,1146,"Patients who remain high transporters with inflammatory reaction might require pharmacologic intervention, including prednisolone therapy.",True,"Is the triple 'Prednisolone treats Inflammation' supported by the sentence: 'Patients who remain high transporters with inflammatory reaction might require pharmacologic intervention, including prednisolone therapy.'?","Yes, the statement ""Patients who remain high transporters with inflammatory reaction might require pharmacologic intervention, including prednisolone therapy."" does indirectly support the claim that Prednisolone treats inflammation. This is because it suggests that prednisolone is used as a treatment for patients who have an inflammatory reaction, implying that prednisolone has an anti-inflammatory effect, which is a form of treatment for inflammation." -9729887,Prednisolone treats glomerulonephritis,1147,"[Comparative characteristics of the spectrum of free amino acids of blood serum and urine in children with glomerulonephritis treated with prednisolone, leukeran and anabolic steroids].",True,"Is the triple 'Prednisolone treats glomerulonephritis' supported by the sentence: '[Comparative characteristics of the spectrum of free amino acids of blood serum and urine in children with glomerulonephritis treated with prednisolone, leukeran and anabolic steroids].'?","Yes, this statement is indirectly supported by the title you provided. The title mentions children with glomerulonephritis being treated with Prednisolone, which suggests that Prednisolone is used in the treatment of this condition. However, it does not explicitly state that Prednisolone treats glomerulonephritis, hence it is indirectly supported." -9717382,Prednisolone treats hemangioma,1148,"Management of hemangioma included observation, prednisolone, flashlamp-pumped pulsed-dye laser, topical therapy and excision in 68 per cent, 8.6 per cent, 10.7 per cent, 9.6 per cent, and 2.5 per cent, respectively.",True,"Is the triple 'Prednisolone treats hemangioma' supported by the sentence: 'Management of hemangioma included observation, prednisolone, flashlamp-pumped pulsed-dye laser, topical therapy and excision in 68 per cent, 8.6 per cent, 10.7 per cent, 9.6 per cent, and 2.5 per cent, respectively.'?","Yes, this statement does provide indirect support for the claim that Prednisolone treats hemangioma. The sentence mentions Prednisolone as one of the management options for hemangiomas, which suggests its use in treating this condition. However, it does not explicitly state that Prednisolone is used for treating hemangiomas, hence it is indirect evidence." -9668241,Prednisolone treats pure red-cell aplasia,1149,The PRCA and AIHA were successfully treated with prednisolone.,True,Is the triple 'Prednisolone treats pure red-cell aplasia' supported by the sentence: 'The PRCA and AIHA were successfully treated with prednisolone.'?,"Yes, this sentence does indirectly support the statement that Prednisolone treats pure red-cell aplasia (PRCA). The sentence mentions that both PRCA and AIHA (Autoimmune Hemolytic Anemia) were successfully treated with prednisolone, which suggests prednisolone has therapeutic effects on PRCA, thus supporting the initial statement." -9538921,Prednisolone treats Graves disease,1150,"She was diagnosed as having Graves' disease and was treated with propylthiouracil, and prednisolone was given for neck pain.",True,"Is the triple 'Prednisolone treats Graves disease' supported by the sentence: 'She was diagnosed as having Graves' disease and was treated with propylthiouracil, and prednisolone was given for neck pain.'?","Yes, the statement ""She was diagnosed as having Graves' disease and was treated with propylthiouracil, and prednisolone was given for neck pain."" does indirectly support the claim ""Prednisolone treats Graves disease"". This is because prednisolone was administered to the patient who was diagnosed with Graves' disease, although it was given for neck pain, not for treating the disease itself. This suggests that prednisolone could potentially have some effect on Graves' disease, even if it was not its primary purpose in this context. However, it is important to note that this does not directly demonstrate that prednisolone is an effective treatment for Graves' disease, as it could have been given for another reason entirely, such as managing symptoms associated with the disease but not directly caused by it, or for an entirely separate condition." -9135976,Prednisolone treats sarcoidosis,1151,"Clinical characteristics, pulmonary function abnormalities and outcome of prednisolone treatment in 106 patients with sarcoidosis.",True,"Is the triple 'Prednisolone treats sarcoidosis' supported by the sentence: 'Clinical characteristics, pulmonary function abnormalities and outcome of prednisolone treatment in 106 patients with sarcoidosis.'?","Yes, this statement is indirectly supported by this sentence as it states prednisolone is being used to treat patients with sarcoidosis, implying it has some therapeutic effect on this condition, even though it does not explicitly state it improves patient outcomes for all patients." -9109448,Prednisolone treats psoriatic arthritis,1152,Methotrexate and prednisolone treatment of a child with psoriatic arthritis.,False,Is the triple 'Prednisolone treats psoriatic arthritis' supported by the sentence: 'Methotrexate and prednisolone treatment of a child with psoriatic arthritis.'?,"No, this statement does not indirectly support that prednisolone treats psoriatic arthritis. The sentence only mentions that methotrexate and prednisolone were used in treating a child with psoriatic arthritis, but it does not specify the role or effect of prednisolone in the treatment." -9077262,Prednisolone treats lymphoma,1153,"This paper presents the results of a prospective study to investigate the prognostic value of clinical staging, histological grading, immunophenotype, mitotic count and average numbers of argyrophilic nucleolar organiser region counts in dogs with multicentric lymphosarcoma treated with a standard chemotherapy protocol comprising vincristine, cyclophosphamide and prednisolone.",True,"Is the triple 'Prednisolone treats lymphoma' supported by the sentence: 'This paper presents the results of a prospective study to investigate the prognostic value of clinical staging, histological grading, immunophenotype, mitotic count and average numbers of argyrophilic nucleolar organiser region counts in dogs with multicentric lymphosarcoma treated with a standard chemotherapy protocol comprising vincristine, cyclophosphamide and prednisolone.'?","Yes, the sentence does indirectly support the statement that Prednisolone treats lymphoma. The sentence mentions that Prednisolone is part of a standard chemotherapy protocol for treating multicentric lymphosarcoma in dogs, which implies its use in treating lymphoma. However, it does not directly state that Prednisolone treats lymphoma, hence the term indirectly." -9061500,Prednisolone treats dermatomyositis,1154,"The administration of prednisolone (60 mg/day) was initiated, which resulted in improvement of DM.",True,"Is the triple 'Prednisolone treats dermatomyositis' supported by the sentence: 'The administration of prednisolone (60 mg/day) was initiated, which resulted in improvement of DM.'?","Yes, this statement does provide indirect support for the assertion that Prednisolone can be used to treat Dermatomyositis (DM). The sentence mentions that administering Prednisolone resulted in an improvement in DM symptoms, indicating its potential therapeutic effect on this condition. However, it should be noted that this is based on one case, so further research would be needed to confirm these findings on a larger scale." -9046445,Prednisolone treats systemic sclerosis,1155,"METHODS: Resting radionuclide ventriculography with 99mTc was performed before and 20 days after the administration of prednisolone, 20 mg daily, in 32 patients with SSc without clinically evident myocardial dysfunction at rest; 13 and 19 patients with systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA), respectively, were studied in parallel as controls.",True,"Is the triple 'Prednisolone treats systemic sclerosis' supported by the sentence: 'METHODS: Resting radionuclide ventriculography with 99mTc was performed before and 20 days after the administration of prednisolone, 20 mg daily, in 32 patients with SSc without clinically evident myocardial dysfunction at rest; 13 and 19 patients with systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA), respectively, were studied in parallel as controls.'?","Yes, this statement does indirectly support that Prednisolone treats systemic sclerosis (SSc). The sentence states that Prednisolone was administered to patients with SSc, which suggests it was used as a treatment for these patients. Additionally, resting radionuclide ventriculography was performed before and after the administration of Prednisolone to assess its effect on cardiac function in SSc patients, implying that there is an interest in its potential therapeutic benefits for this condition. However, it is important to note that this does not directly prove Prednisolone's efficacy in treating SSc, as further studies would be needed to establish its therapeutic value." -9013774,Prednisolone treats ocular pemphigoid,1156,METHODS: Three patients with CP were treated with mycophenolate mofetil and prednisolone.,True,Is the triple 'Prednisolone treats ocular pemphigoid' supported by the sentence: 'METHODS: Three patients with CP were treated with mycophenolate mofetil and prednisolone.'?,"Yes, it is indirectly supported because it mentions prednisolone being used in treatment, but it doesn't specifically state it is used for ocular pemphigoid in this sentence. The sentence only states it was used in conjunction with mycophenolate mofetil to treat three patients with chronic plaque (CP). However, prednisolone is indeed used to treat various conditions, including ocular pemphigoid, so it is not contradictory to the initial statement, but it is not explicitly stated either." -8939337,Prednisolone treats membranous glomerulonephritis,1157,He was diagnosed as having membranous nephropathy by renal biopsy and was treated with prednisolone.,True,Is the triple 'Prednisolone treats membranous glomerulonephritis' supported by the sentence: 'He was diagnosed as having membranous nephropathy by renal biopsy and was treated with prednisolone.'?,"Yes, this statement indirectly supports the claim that Prednisolone treats membranous glomerulonephritis, as it mentions the use of prednisolone in treating a patient diagnosed with membranous nephropathy, which is a type of membranous glomerulonephritis. However, it does not directly prove that prednisolone is effective in treating this condition, as it only shows its use in one case without any mention of its therapeutic effects in this particular patient." -8906209,Prednisolone treats allergic disease,1158,"Clinically, both prednisolone and prednisolone sodium succinate are widely used as immunosuppressive agents for the treatment of various allergic disorders.",True,"Is the triple 'Prednisolone treats allergic disease' supported by the sentence: 'Clinically, both prednisolone and prednisolone sodium succinate are widely used as immunosuppressive agents for the treatment of various allergic disorders.'?","Yes, this statement does indirectly support the triple ""Prednisolone treats allergic disease"". The sentence provided mentions both prednisolone and prednisolone sodium succinate, which is a salt form of prednisolone, as widely used immunosuppressive agents for treating various allergic disorders. This implies that prednisolone is used to manage allergic diseases, thus supporting the triple statement." -8865745,Prednisolone treats subacute thyroiditis,1159,CONCLUSIONS: The recurrence rate of SAT with treated PSL is about 20%.,True,Is the triple 'Prednisolone treats subacute thyroiditis' supported by the sentence: 'CONCLUSIONS: The recurrence rate of SAT with treated PSL is about 20%.'?,"Yes, this statement can be interpreted as indirectly supporting the claim that Prednisolone (PSL) treats Subacute Thyroiditis (SAT). The conclusion suggests that about 20% of SAT patients treated with PSL experience recurrence, implying that PSL has some therapeutic effect in managing SAT. However, it doesn't directly state that Prednisolone treats SAT, but rather implies it through the context of the recurrence rate." -8819323,Prednisolone treats meningeal tuberculosis,1160,"In this case, prednisolone was indispensable for treating tuberculous meningitis in combination with appropriate antituberculosis drugs, though the role of corticosteroids has remained controversial over the years.",True,"Is the triple 'Prednisolone treats meningeal tuberculosis' supported by the sentence: 'In this case, prednisolone was indispensable for treating tuberculous meningitis in combination with appropriate antituberculosis drugs, though the role of corticosteroids has remained controversial over the years.'?","Yes, this statement does indirectly support the claim that Prednisolone treats meningeal tuberculosis. The sentence states that prednisolone was indispensable for treating tuberculous meningitis, which is a type of meningeal tuberculosis, in combination with appropriate antituberculosis drugs. However, it also mentions that the role of corticosteroids, which includes prednisolone, has been controversial, indicating that while it is used, its effectiveness is still debated in medical communities." -8755027,Prednisolone treats hypereosinophilic syndrome,1161,"Prednisolone (PSL) was administered, which improved the anemia, eosinophilia and the cavities.",True,"Is the triple 'Prednisolone treats hypereosinophilic syndrome' supported by the sentence: 'Prednisolone (PSL) was administered, which improved the anemia, eosinophilia and the cavities.'?","Yes, this statement can be seen as indirectly supporting the claim that Prednisolone treats Hypereosinophilic syndrome (HES). HES is characterized by an elevated level of eosinophils in the blood, which can lead to organ damage, anemia, and other symptoms. Prednisolone, a corticosteroid, is often used to treat HES because it can suppress eosinophil production. The sentence mentions that Prednisolone improved the anemia, eosinophilia (which means high level of eosinophils), and cavities, which aligns with its expected effects in treating HES. However, it's important to note that this is an indirect inference, as the sentence does not explicitly state that the patient had HES." -8752241,Prednisolone treats West syndrome,1162,"BACKGROUND: The use of adrenocorticotrophic hormone (ACTH) and prednisolone in the management of infantile spasms has been well established, but is associated with significant morbidity and cannot be used as long-term medication.",True,"Is the triple 'Prednisolone treats West syndrome' supported by the sentence: 'BACKGROUND: The use of adrenocorticotrophic hormone (ACTH) and prednisolone in the management of infantile spasms has been well established, but is associated with significant morbidity and cannot be used as long-term medication.'?","Yes, this statement can be seen as providing indirect support for the claim that Prednisolone can treat West Syndrome (infantile spasms). The sentence mentions the use of Prednisolone in managing infantile spasms, which is one of the symptoms associated with West Syndrome, although it also points out potential issues with its long-term use." -8647269,Prednisolone treats pulmonary tuberculosis,1163,"However, he died because of lung tuberculosis and acute tuberculous pericarditis during treatment with prednisolone.",False,"Is the triple 'Prednisolone treats pulmonary tuberculosis' supported by the sentence: 'However, he died because of lung tuberculosis and acute tuberculous pericarditis during treatment with prednisolone.'?","No, this statement does not support the claim that Prednisolone treats pulmonary tuberculosis. In fact, it suggests the opposite - that despite treatment with prednisolone, the patient died from lung tuberculosis and acute tuberculous pericarditis. Prednisolone is a corticosteroid, which can be used to treat inflammation associated with certain diseases, but it is not typically used as a primary treatment for active tuberculosis." -8583398,Prednisolone treats leprosy,1164,"In untreated reactional leprosy patients, the levels of urinary NO metabolites (1645 +/- 454 microM, n = 9, ENL = 4, RR = 5) decreased significantly 2 weeks after high dose prednisolone treatment (1075 +/- 414 microM, P < 0.05), and remained stable 4 (895 +/- 385 microM, P < 0.02) and 6 weeks following treatment initiation (1048 +/- 452 microM, P < 0.02).",False,"Is the triple 'Prednisolone treats leprosy' supported by the sentence: 'In untreated reactional leprosy patients, the levels of urinary NO metabolites (1645 +/- 454 microM, n = 9, ENL = 4, RR = 5) decreased significantly 2 weeks after high dose prednisolone treatment (1075 +/- 414 microM, P < 0.05), and remained stable 4 (895 +/- 385 microM, P < 0.02) and 6 weeks following treatment initiation (1048 +/- 452 microM, P < 0.02).'?","No, this sentence does not indirectly support the statement that Prednisolone treats leprosy. The sentence only mentions that Prednisolone can decrease urinary NO metabolites levels in reactional leprosy patients, but it does not confirm that Prednisolone is used to treat leprosy itself." -8573433,Prednisolone treats alcoholic hepatitis,1165,"Prednisolone improves survival in patients with alcoholic hepatitis who have either spontaneous hepatic encephalopathy or a high ""discriminant function.",True,"Is the triple 'Prednisolone treats alcoholic hepatitis' supported by the sentence: 'Prednisolone improves survival in patients with alcoholic hepatitis who have either spontaneous hepatic encephalopathy or a high ""discriminant function.'?","Yes, this statement is indirectly supported by the provided sentence, as it suggests that Prednisolone can improve survival in patients with alcoholic hepatitis, particularly those who have complications such as spontaneous hepatic encephalopathy or a high discriminant function, which is associated with severe disease progression. Therefore, it implies that Prednisolone could potentially treat alcoholic hepatitis indirectly, as it may help to manage its complications, which could lead to improved outcomes for patients suffering from this condition." -8540122,Prednisolone treats autoimmune hemolytic anemia,1166,She had received prednisolone (PSL) therapy for autoimmune hemolytic anemia (AIHA).,True,Is the triple 'Prednisolone treats autoimmune hemolytic anemia' supported by the sentence: 'She had received prednisolone (PSL) therapy for autoimmune hemolytic anemia (AIHA).'?,"Yes, this statement does provide indirect support for the claim that Prednisolone (PSL) can treat Autoimmune Hemolytic Anemia (AIHA). The sentence states that PSL therapy was given to treat AIHA, which implies that PSL is used as a treatment for AIHA, as indicated in the original claim. However, it should be noted that this is an indirect inference, as it does not directly show Prednisolone treating AIHA, but rather implies it through the context provided in the sentence." -8499057,Prednisolone treats lupus nephritis,1167,"CONCLUSIONS: For the treatment of diffuse proliferative lupus nephritis, the combination of mycophenolate mofetil and prednisolone is as effective as a regimen of cyclophosphamide and prednisolone followed by azathioprine and prednisolone but is less toxic.",True,"Is the triple 'Prednisolone treats lupus nephritis' supported by the sentence: 'CONCLUSIONS: For the treatment of diffuse proliferative lupus nephritis, the combination of mycophenolate mofetil and prednisolone is as effective as a regimen of cyclophosphamide and prednisolone followed by azathioprine and prednisolone but is less toxic.'?","Yes, this sentence does indirectly support the statement that Prednisolone treats lupus nephritis. The sentence states that a combination therapy including Prednisolone is effective in treating diffuse proliferative lupus nephritis, which is a type of kidney inflammation associated with systemic lupus erythematosus (SLE), also known as lupus. Therefore, it suggests that Prednisolone has a role in treating lupus nephritis, even though it does not directly mention Prednisolone as a standalone treatment." -8455402,Prednisolone treats chronic obstructive pulmonary disease,1168,Additive effects of prednisolone and beclomethasone dipropionate in patients with stable chronic obstructive pulmonary disease.,False,Is the triple 'Prednisolone treats chronic obstructive pulmonary disease' supported by the sentence: 'Additive effects of prednisolone and beclomethasone dipropionate in patients with stable chronic obstructive pulmonary disease.'?,"No, this statement does not indirectly support the claim that Prednisolone treats chronic obstructive pulmonary disease (COPD). The sentence provided states that there is an additive effect when Prednisolone is used in combination with beclomethasone dipropionate in patients with stable COPD, but it does not imply that Prednisolone alone is an effective treatment for COPD." -8268574,Prednisolone treats thrombocytopenia,1169,Three out of 8 patients with thrombocytopenia were treated with prednisolone according to the protocol for idiopathic thrombocytopenic purpura.,True,Is the triple 'Prednisolone treats thrombocytopenia' supported by the sentence: 'Three out of 8 patients with thrombocytopenia were treated with prednisolone according to the protocol for idiopathic thrombocytopenic purpura.'?,"Yes, this statement does indirectly support the claim that Prednisolone treats thrombocytopenia in the context of idiopathic thrombocytopenic purpura (ITP). The sentence states that three out of eight patients with thrombocytopenia were treated with Prednisolone, which suggests that Prednisolone was used as a treatment for their low platelet count (thrombocytopenia). However, it does not directly state that Prednisolone treats thrombocytopenia, but rather implies it in the context of ITP treatment according to a specific protocol." -7990669,Prednisolone treats non-Hodgkin lymphoma,1170,"A regimen which incorporates cyclophosphamide, doxorubicin, vincristine and prednisolone (CHOP) is the standard treatment for patients with non-Hodgkin's lymphoma (NHL), but it has not been effective in patients with aggressive NHL who are at high risk.",False,"Is the triple 'Prednisolone treats non-Hodgkin lymphoma' supported by the sentence: 'A regimen which incorporates cyclophosphamide, doxorubicin, vincristine and prednisolone (CHOP) is the standard treatment for patients with non-Hodgkin's lymphoma (NHL), but it has not been effective in patients with aggressive NHL who are at high risk.'?","No, this statement does not indirectly support the claim that Prednisolone treats non-Hodgkin lymphoma. The sentence you provided mentions Prednisolone as part of a treatment regimen (CHOP) for non-Hodgkin lymphoma, but it also states that this regimen has not been effective in patients with aggressive NHL who are at high risk. Therefore, it does not provide evidence that Prednisolone alone is effective in treating non-Hodgkin lymphoma." -7986379,Prednisolone treats Crohn disease,1171,"In a stepwise regression that included age, sex, disease duration and cumulative prednisolone dose as independent variables, the femur T score was significantly inversely related to disease duration (r2 = 0.125, F = 6.06) in CD patients.",False,"Is the triple 'Prednisolone treats Crohn disease' supported by the sentence: 'In a stepwise regression that included age, sex, disease duration and cumulative prednisolone dose as independent variables, the femur T score was significantly inversely related to disease duration (r2 = 0.125, F = 6.06) in CD patients.'?","No, this statement does not indirectly support the claim that Prednisolone treats Crohn disease. The sentence provided discusses the relationship between various factors, including cumulative prednisolone dose, and bone density in patients with Crohn disease (CD). It does not provide any information about the efficacy of Prednisolone in treating CD itself." -7985554,Prednisolone treats acute lymphoblastic leukemia,1172,"A regime of treatment of acute non-lymphoblastic leukemia in adult, employing DMCP protocol, especially two step method consisting of daunorubicin, cytosine arabinoside, 6-mercaptopurine and prednisolone is described.",True,"Is the triple 'Prednisolone treats acute lymphoblastic leukemia' supported by the sentence: 'A regime of treatment of acute non-lymphoblastic leukemia in adult, employing DMCP protocol, especially two step method consisting of daunorubicin, cytosine arabinoside, 6-mercaptopurine and prednisolone is described.'?","Yes, this statement can be seen as indirectly supporting the claim that Prednisolone is used to treat acute lymphoblastic leukemia, even though it specifically mentions acute non-lymphoblastic leukemia in adults. The key here is the mention of Prednisolone as part of a treatment regimen for leukemia, regardless of whether it is specifically for acute lymphoblastic leukemia (ALL) or not. However, it is important to note that direct evidence linking Prednisolone specifically to ALL would be stronger support for this claim." -7941298,Prednisolone treats granulomatosis with polyangiitis,1173,"Two patients with Wegener's granulomatosis have been treated with chlorambucil and prednisolone continuosly for 3 and 5 years, respectively.",True,"Is the triple 'Prednisolone treats granulomatosis with polyangiitis' supported by the sentence: 'Two patients with Wegener's granulomatosis have been treated with chlorambucil and prednisolone continuosly for 3 and 5 years, respectively.'?","Yes, this sentence does provide indirect support for the statement ""Prednisolone treats granulomatosis with polyangiitis"" (also known as Wegener's granulomatosis). The sentence mentions two patients with Wegener’s granulomatosis who were treated continuously for several years with chlorambucil and prednisolone, suggesting that prednisolone was used as part of their treatment regimen for this condition. However, it does not directly state that prednisolone specifically is responsible for treating the condition, hence it is indirect support." -7927983,Prednisolone treats nephrotic syndrome,1174,"The second patient, a 73-year-old man receiving prednisolone therapy for nephrotic syndrome, developed right leg cellulitis that evolved to NF.",True,"Is the triple 'Prednisolone treats nephrotic syndrome' supported by the sentence: 'The second patient, a 73-year-old man receiving prednisolone therapy for nephrotic syndrome, developed right leg cellulitis that evolved to NF.'?","Yes, this statement does provide indirect support for the claim that prednisolone can be used to treat nephrotic syndrome. The patient in question was already receiving prednisolone therapy for nephrotic syndrome, which suggests that prednisolone is being used as part of the treatment regimen for this condition. The development of cellulitis in this patient does not negate this fact, but rather adds an additional complication to their health status. However, it is important to note that this does not directly prove that prednisolone is effective in treating nephrotic syndrome, as it could be one part of a larger treatment plan, or it could be ineffective for this particular patient but still part of standard treatment protocols." -7900660,Prednisolone treats temporal arteritis,1175,"At the time of diagnosis, patients with GCA had an increased median serum level of YKL-40 (256 microg/liter; P<0.01) compared with healthy age-matched controls (median 118 microg/liter), and the serum level of YKL-40 decreased to normal levels during prednisolone treatment (-38% after 1 month; P<0.001).",True,"Is the triple 'Prednisolone treats temporal arteritis' supported by the sentence: 'At the time of diagnosis, patients with GCA had an increased median serum level of YKL-40 (256 microg/liter; P<0.01) compared with healthy age-matched controls (median 118 microg/liter), and the serum level of YKL-40 decreased to normal levels during prednisolone treatment (-38% after 1 month; P<0.001).'?","Yes, the statement is indirectly supported by this sentence. This is because it mentions that serum levels of YKL-40 decreased during prednisolone treatment in patients with GCA (giant cell arteritis), which is an inflammatory condition also known as temporal arteritis. This suggests that prednisolone could be an effective treatment for reducing inflammation in this condition, as indicated by the decrease in YKL-40 levels, which is associated with inflammation. However, it does not explicitly state that prednisolone is used to treat temporal arteritis, but it does provide evidence for its potential use in treating inflammatory conditions like it, thus being indirectly supported." -7900659,Prednisolone treats polymyalgia rheumatica,1176,Most patients with PMR had normal serum YKL-40 levels (median 158 microg/liter) and had no changes in the serum YKL-40 levels during prednisolone treatment.,False,Is the triple 'Prednisolone treats polymyalgia rheumatica' supported by the sentence: 'Most patients with PMR had normal serum YKL-40 levels (median 158 microg/liter) and had no changes in the serum YKL-40 levels during prednisolone treatment.'?,"No, this sentence does not support the statement that Prednisolone treats polymyalgia rheumatica (PMR). In fact, it suggests the opposite. The sentence indicates that most patients with PMR had normal serum YKL-40 levels both before and after prednisolone treatment, implying that the prednisolone may not be directly influencing the condition. However, it is important to note that this is based on one specific marker, YKL-40, and other factors could still be at play." -7866839,Prednisolone treats acute myeloid leukemia,1177,"Treatment of acute myeloid leukemia of childhood with cytosine arabinoside, daunorubicin, prednisolone, and mercaptopurine or thioguanine.",True,"Is the triple 'Prednisolone treats acute myeloid leukemia' supported by the sentence: 'Treatment of acute myeloid leukemia of childhood with cytosine arabinoside, daunorubicin, prednisolone, and mercaptopurine or thioguanine.'?","Yes, the statement is indirectly supported because prednisolone is mentioned as one of the treatments for acute myeloid leukemia in childhood, as per the given sentence." -7819165,Prednisolone treats systemic lupus erythematosus,1178,Subacute severe steatohepatitis during prednisolone therapy for systemic lupus erythematosis.,True,Is the triple 'Prednisolone treats systemic lupus erythematosus' supported by the sentence: 'Subacute severe steatohepatitis during prednisolone therapy for systemic lupus erythematosis.'?,"Yes, it is indirectly supported by the sentence provided. The sentence states that subacute severe steatohepatitis occurred during prednisolone therapy for systemic lupus erythematosus (SLE). Prednisolone is a type of corticosteroid, which is often used to treat SLE due to its anti-inflammatory effects. However, long-term use of corticosteroids like prednisolone can lead to side effects such as steatohepatitis, which is inflammation of the liver due to fat accumulation. Therefore, while prednisolone is used to treat SLE, its use can also lead to complications like steatohepatitis, as suggested in this sentence." -7800931,Prednisolone treats autoimmune thrombocytopenic purpura,1179,"However, after administration of immunoglobulin (IVIG) (0.4 g/kg/day x 5 days), low-dose PSL (20 mg/day) alleviated the LEMS and ITP, and the diseases have remained in remission for 8 months without additional IVIG.",True,"Is the triple 'Prednisolone treats autoimmune thrombocytopenic purpura' supported by the sentence: 'However, after administration of immunoglobulin (IVIG) (0.4 g/kg/day x 5 days), low-dose PSL (20 mg/day) alleviated the LEMS and ITP, and the diseases have remained in remission for 8 months without additional IVIG.'?","Yes, this sentence does indirectly support the statement that Prednisolone (PSL) treats autoimmune thrombocytopenic purpura (ITP). The sentence mentions that after administration of immunoglobulin (IVIG), low-dose PSL (which is Prednisolone) was used to alleviate ITP, and the disease has remained in remission for 8 months without additional IVIG. This suggests that Prednisolone was effective in treating ITP, at least in this specific case. However, it's important to note that this is based on one case study, so further research would be needed to confirm this finding." -7704078,Prednisolone treats colitis,1180,"On the other hand, prednisolone and short chain fatty acids seemed to improve only the physiologic changes of colitis.",True,"Is the triple 'Prednisolone treats colitis' supported by the sentence: 'On the other hand, prednisolone and short chain fatty acids seemed to improve only the physiologic changes of colitis.'?","Yes, the sentence does provide indirect support for the statement ""Prednisolone treats colitis"". The sentence mentions that prednisolone seemed to improve only the physiologic changes of colitis, which implies that prednisolone has some positive effect on colitis, thus providing support for the statement that prednisolone treats colitis, albeit indirectly. Short chain fatty acids also seemed to improve only the physiologic changes of colitis, but since they were mentioned alongside prednisolone, it is assumed they were being compared, further emphasizing prednisolone's effect on colitis." -7676165,Prednisolone treats hypercalcemia disease,1181,"Treatment with extracorporeal shock wave lithotripsy, transurethral lithotomy, saline infusion, and prednisolone (30 mg/day) alleviated the urolithiasis, renal insufficiency, and hypercalcemia.",True,"Is the triple 'Prednisolone treats hypercalcemia disease' supported by the sentence: 'Treatment with extracorporeal shock wave lithotripsy, transurethral lithotomy, saline infusion, and prednisolone (30 mg/day) alleviated the urolithiasis, renal insufficiency, and hypercalcemia.'?","Yes, the statement is indirectly supported because prednisolone is used in treating hypercalcemia which is one component in the mentioned sentence, along with other treatments, to alleviate urolithiasis, renal insufficiency, and hypercalcemia. However, it does not explicitly state prednisolone is used to treat hypercalcemia in this particular case, but it is still associated with its treatment in this context." -7603475,Prednisolone treats Duchenne muscular dystrophy,1182,A special program for long-term application of low-dose prednisolone treatment in Duchenne-Becker muscular dystrophy with complex control of the patients' state was developed.,True,Is the triple 'Prednisolone treats Duchenne muscular dystrophy' supported by the sentence: 'A special program for long-term application of low-dose prednisolone treatment in Duchenne-Becker muscular dystrophy with complex control of the patients' state was developed.'?,"Yes, this statement does provide indirect support for the idea that Prednisolone can be used to treat Duchenne muscular dystrophy (DMD). The sentence mentions a special program for long-term application of low-dose prednisolone treatment specifically in Duchenne-Becker muscular dystrophy, which suggests that prednisolone has therapeutic value for this condition. However, it does not directly state that Prednisolone treats DMD, hence the indirect support." -7600829,Prednisolone treats multiple sclerosis,1183,"Long-term open-trial of mizoribine with prednisolone in 24 patients with multiple sclerosis: safety, clinical and magnetic resonance imaging outcome.",False,"Is the triple 'Prednisolone treats multiple sclerosis' supported by the sentence: 'Long-term open-trial of mizoribine with prednisolone in 24 patients with multiple sclerosis: safety, clinical and magnetic resonance imaging outcome.'?","No, this sentence does not indirectly support the statement that Prednisolone treats multiple sclerosis. The sentence is about a study involving mizoribine and prednisolone in patients with multiple sclerosis, but it does not specify the effects of prednisolone alone. Therefore, it does not provide evidence that prednisolone is a treatment for multiple sclerosis." -7586864,Prednisolone treats ulcerative colitis,1184,A 25-year-old man had been treated with high-dose prednisolone for UC.,True,Is the triple 'Prednisolone treats ulcerative colitis' supported by the sentence: 'A 25-year-old man had been treated with high-dose prednisolone for UC.'?,"Yes, the sentence does provide indirect support for the statement that Prednisolone treats ulcerative colitis (UC). The mention of a 25-year-old man being treated with high-dose Prednisolone for UC suggests that Prednisolone is used as a treatment for UC. However, it does not directly imply that Prednisolone is effective in treating UC, but it does provide evidence for its use in treatment." -7485161,Prednisolone treats uveitis,1185,DISCUSSION: Allopurinol is more effective than prednisolone in treating EAU.,False,Is the triple 'Prednisolone treats uveitis' supported by the sentence: 'DISCUSSION: Allopurinol is more effective than prednisolone in treating EAU.'?,"No, this statement does not support the triple statement ""Prednisolone treats uveitis"". In fact, it suggests Allopurinol is more effective than Prednisolone in treating EAU (Experimental Autoimmune Uveoretinitis), which implies Prednisolone may not be as effective in treating EAU as Allopurinol, not necessarily that Prednisolone is not effective in treating uveitis in general." -7430895,Prednisolone treats asthma,1186,"Interleukin-5 mRNA was detected in all asthmatics before prednisolone therapy; however, after prednisolone therapy, IL-5 mRNA was only detected in non-GCS-responsive BHR asthmatics.",True,"Is the triple 'Prednisolone treats asthma' supported by the sentence: 'Interleukin-5 mRNA was detected in all asthmatics before prednisolone therapy; however, after prednisolone therapy, IL-5 mRNA was only detected in non-GCS-responsive BHR asthmatics.'?","Yes, this statement does indirectly support the claim that Prednisolone treats asthma, specifically in certain subtypes of asthmatic patients. In this sentence, it is mentioned that Interleukin-5 (IL-5) mRNA was detected in all asthmatic patients before prednisolone therapy, implying an association between IL-5 levels and asthma symptoms. After prednisolone therapy, IL-5 mRNA was only detected in non-GCS-responsive BHR (Bronchial Hyperresponsiveness) asthmatic patients, which could suggest that prednisolone is effective in reducing IL-5 levels in certain subtypes of asthmatic patients, potentially alleviating their symptoms. However, this does not directly prove that prednisolone is effective in treating asthma in general, as it may not work for all subtypes, including GCS-responsive BHR asthmatic patients, as mentioned in the statement." -7417999,Prednisolone treats IgA glomerulonephritis,1187,"Combined therapy with prednisolone, azathioprine, heparin-warfarin, and dipyridamole for paediatric patients with severe IgA nephropathy--is it relevant for adult patients?",False,"Is the triple 'Prednisolone treats IgA glomerulonephritis' supported by the sentence: 'Combined therapy with prednisolone, azathioprine, heparin-warfarin, and dipyridamole for paediatric patients with severe IgA nephropathy--is it relevant for adult patients?'?","No, this statement does not provide direct or indirect support for the claim that Prednisolone treats IgA glomerulonephritis. The sentence discusses combined therapy for severe IgA nephropathy in paediatric patients, but it does not specify which component of the therapy is responsible for treating IgA nephropathy, nor does it mention IgA glomerulonephritis specifically." -7158230,Prednisolone treats rheumatoid arthritis,1188,Remission of the nephrotic syndrome in a patient with renal amyloidosis due to rheumatoid arthritis treated with prednisolone and methotrexate.,True,Is the triple 'Prednisolone treats rheumatoid arthritis' supported by the sentence: 'Remission of the nephrotic syndrome in a patient with renal amyloidosis due to rheumatoid arthritis treated with prednisolone and methotrexate.'?,"Yes, there is indirect support for the statement based on the provided sentence. The sentence mentions a patient with renal amyloidosis due to rheumatoid arthritis who was treated with prednisolone (among other treatments). The fact that remission was achieved suggests that prednisolone had a positive impact on the symptoms of rheumatoid arthritis in this patient, even though it was used in combination with methotrexate. This does not directly state that prednisolone alone treats rheumatoid arthritis, but it does provide some evidence for its effectiveness in managing symptoms of the disease, which is a form of support." -23769275,Hydrocortisone treats leukemia,1189,"Study protocol: DexaDays-2, hydrocortisone for treatment of dexamethasone-induced neurobehavioral side effects in pediatric leukemia patients: a double-blind placebo controlled randomized intervention study with cross-over design.",False,"Is the triple 'Hydrocortisone treats leukemia' supported by the sentence: 'Study protocol: DexaDays-2, hydrocortisone for treatment of dexamethasone-induced neurobehavioral side effects in pediatric leukemia patients: a double-blind placebo controlled randomized intervention study with cross-over design.'?","No, this statement does not indirectly support that hydrocortisone treats leukemia. The study mentioned is investigating the use of hydrocortisone to manage dexamethasone-induced neurobehavioral side effects in pediatric leukemia patients, not to treat leukemia itself." -22345112,Hydrocortisone treats oral submucous fibrosis,1190,"Aims and Objective: To evaluate the efficacy of injection placentrex and injection hydrocortisone in oral submucous fibrosis patients in increasing mouth opening, burning sensation, and improve the mucosal lining.",True,"Is the triple 'Hydrocortisone treats oral submucous fibrosis' supported by the sentence: 'Aims and Objective: To evaluate the efficacy of injection placentrex and injection hydrocortisone in oral submucous fibrosis patients in increasing mouth opening, burning sensation, and improve the mucosal lining.'?","Yes, this is indirectly supported. The sentence mentions an aim to evaluate the efficacy (effectiveness) of injection hydrocortisone in treating symptoms associated with oral submucous fibrosis, which includes increased mouth opening, reduced burning sensation, and improved mucosal lining, as stated in the sentence provided." -22282269,Hydrocortisone treats Infection,1191,"The results presented herein imply that the three families of cyanine dyes, in particular compounds 5a-f, show high potential as selective scaffolds to treat C. albicans infections.",False,"Is the triple 'Hydrocortisone treats Infection' supported by the sentence: 'The results presented herein imply that the three families of cyanine dyes, in particular compounds 5a-f, show high potential as selective scaffolds to treat C. albicans infections.'?","No, this statement does not indirectly support the claim that hydrocortisone treats infections. The sentence provided discusses the potential of certain cyanine dyes as selective scaffolds to treat C. albicans infections, but it does not mention hydrocortisone or infections caused by anything other than C. albicans. Hydrocortisone is a corticosteroid hormone used primarily for its anti-inflammatory effects, not for treating infections, especially those caused by C. albicans. Therefore, there is no implicit support for the initial claim in this statement." -21368080,Hydrocortisone treats lymphoma,1192,The serum cortisol concentration in the LYMPH patients was 285 +/- 74 nmol/l.,False,Is the triple 'Hydrocortisone treats lymphoma' supported by the sentence: 'The serum cortisol concentration in the LYMPH patients was 285 +/- 74 nmol/l.'?,"No, this statement does not provide direct support for the claim that hydrocortisone treats lymphoma. The serum cortisol concentration in lymph patients being 285 +/- 74 nmol/l only provides information about cortisol levels in lymph patients, not about the effectiveness of hydrocortisone in treating lymphoma. Hydrocortisone is a synthetic form of cortisol, a hormone that the body produces naturally in response to stress, so this statement doesn't imply any correlation between hydrocortisone and treatment of lymphoma." -19834754,Hydrocortisone treats cardiac arrest,1193,"Compared to controls, glycocalyx was mildly injured by CA, severely disrupted by hyaluronidase (HAase) with CA, and mitigated by hydrocortisone (HC) with CA.",False,"Is the triple 'Hydrocortisone treats cardiac arrest' supported by the sentence: 'Compared to controls, glycocalyx was mildly injured by CA, severely disrupted by hyaluronidase (HAase) with CA, and mitigated by hydrocortisone (HC) with CA.'?","No, this statement does not provide direct support for the claim that hydrocortisone treats cardiac arrest (CA). The sentence only mentions that hydrocortisone (HC) mitigated glycocalyx injury when used in combination with CA, not that it directly treats CA itself." -17499762,Hydrocortisone treats dermatitis,1194,"In the acute phase of dermatitis, topical hydrocortisone treatment has both a local and a systemic effect, due to percutaneous absorption.",True,"Is the triple 'Hydrocortisone treats dermatitis' supported by the sentence: 'In the acute phase of dermatitis, topical hydrocortisone treatment has both a local and a systemic effect, due to percutaneous absorption.'?","Yes, this statement is indirectly supported by the sentence provided. The sentence mentions topical hydrocortisone treatment as having both local and systemic effects in the acute phase of dermatitis, which implies that hydrocortisone can help manage symptoms of dermatitis, thus treating it indirectly." -16946872,Hydrocortisone treats adrenal cortex neoplasm,1195,"The mean (+/- SD) plasma cortisol concentration for the initial 8-hour testing period was highest in 18 dogs with adrenocortical tumor (5.3 +/- 1.6 micrograms/dl), lowest in 15 control dogs (1.3 +/- 0.5 micrograms/dl), and intermediate in 31 dogs with pituitary-dependent hyperadrenocorticism (PDH; 3.4 +/- 1.2 micrograms/dl).",True,"Is the triple 'Hydrocortisone treats adrenal cortex neoplasm' supported by the sentence: 'The mean (+/- SD) plasma cortisol concentration for the initial 8-hour testing period was highest in 18 dogs with adrenocortical tumor (5.3 +/- 1.6 micrograms/dl), lowest in 15 control dogs (1.3 +/- 0.5 micrograms/dl), and intermediate in 31 dogs with pituitary-dependent hyperadrenocorticism (PDH; 3.4 +/- 1.2 micrograms/dl).'?","Yes, this statement does provide indirect support for the idea that hydrocortisone, which is a type of steroid hormone produced in the adrenal cortex, could potentially be used to treat adrenal cortex neoplasm (a type of tumor). The sentence provides data showing that dogs with an adrenocortical tumor have significantly higher plasma cortisol concentrations compared to control dogs, indicating an overproduction of cortisol in these dogs due to the tumor in their adrenal gland. - - Hydrocortisone, as well as other glucocorticoids, can be used to suppress endogenous corticosteroid production in dogs, helping to manage hyperadrenocorticism, which is often associated with pituitary-dependent hyperadrenocorticism (PDH) but can also be caused by tumors in the adrenal gland itself (adrenocortical tumor). Therefore, hydrocortisone might be used as a treatment for lowering excessive steroid hormones in cases where an adrenal gland tumor is present, although this would depend on various factors such as tumor type, size, location," -15753359,Hydrocortisone treats dissociative amnesia,1196,Our results suggest that PL may increase the availability of cortisol in chronically stressed men and may attenuate stress-induced memory impairments.,False,Is the triple 'Hydrocortisone treats dissociative amnesia' supported by the sentence: 'Our results suggest that PL may increase the availability of cortisol in chronically stressed men and may attenuate stress-induced memory impairments.'?,"No, this statement is not indirectly supported by this sentence. The sentence suggests that prefrontal cortex stimulation (PL) may increase cortisol availability in chronically stressed men, which may attenuate stress-induced memory impairments. Hydrocortisone is a synthetic form of cortisol, but there is no mention of it being used in this study, nor is there any direct or indirect reference to it treating dissociative amnesia in this sentence." -15602187,Hydrocortisone treats Hypoxemia,1197,All inhibitors prevented the rise in cortisol secretion usually observed in hypoxic dogs.,False,Is the triple 'Hydrocortisone treats Hypoxemia' supported by the sentence: 'All inhibitors prevented the rise in cortisol secretion usually observed in hypoxic dogs.'?,"No, this statement does not provide direct support for the claim that hydrocortisone, specifically, treats hypoxemia (a condition characterized by low oxygen levels in the blood). The sentence only mentions that all inhibitors, not specifically hydrocortisone, prevented the rise in cortisol secretion in hypoxic dogs. Cortisol is a hormone released in response to stress, including low oxygen levels, but this does not directly link hydrocortisone to the treatment of hypoxemia." -15325707,Hydrocortisone treats psoriasis,1198,"The expression of StAR and MLN64 was aberrant in two skin disorders, psoriasis and atopic dermatitis, that are commonly treated with cortisol, suggesting dysregulation of epidermal steroid synthesis in these patients.",True,"Is the triple 'Hydrocortisone treats psoriasis' supported by the sentence: 'The expression of StAR and MLN64 was aberrant in two skin disorders, psoriasis and atopic dermatitis, that are commonly treated with cortisol, suggesting dysregulation of epidermal steroid synthesis in these patients.'?","Yes, this statement could indirectly support the idea that hydrocortisone, which is a type of cortisol, could be used to treat psoriasis. The sentence mentions that cortisol is commonly used to treat psoriasis, and hydrocortisone is a form of cortisol. However, it's important to note that this is an indirect inference, as the original sentence does not specifically mention hydrocortisone. The dysregulation of epidermal steroid synthesis suggested in the sentence could potentially be corrected by various forms of cortisol, including hydrocortisone, but this is not explicitly stated in the sentence." -15213238,Hydrocortisone treats herpes labialis,1199,"ME-609 (Xerese, Xerclear) is a combination of 5% acyclovir and 1% hydrocortisone developed for the topical treatment of HSL.",True,"Is the triple 'Hydrocortisone treats herpes labialis' supported by the sentence: 'ME-609 (Xerese, Xerclear) is a combination of 5% acyclovir and 1% hydrocortisone developed for the topical treatment of HSL.'?","Yes, this statement is indirectly supported, as it mentions hydrocortisone being used in combination with acyclovir to treat Herpes Labialis Simplex (HSL). However, it does not explicitly state that hydrocortisone alone can treat HSL, but it does suggest its potential role in managing symptoms when used in combination therapy." -14532907,Hydrocortisone treats cirrhosis of liver,1200,The urinary ratio of 6 beta-hydroxycortisol/cortisol (6 beta-OHC/C) as a biomarker of CYP3A4 metabolizing activity has been studied in Egyptian patients with chronic liver cirrhosis associated with previous hepatic Schistosomiasis infection to determine any possible alteration in enzyme activity.,False,Is the triple 'Hydrocortisone treats cirrhosis of liver' supported by the sentence: 'The urinary ratio of 6 beta-hydroxycortisol/cortisol (6 beta-OHC/C) as a biomarker of CYP3A4 metabolizing activity has been studied in Egyptian patients with chronic liver cirrhosis associated with previous hepatic Schistosomiasis infection to determine any possible alteration in enzyme activity.'?,"No, this statement does not directly support the claim that hydrocortisone treats liver cirrhosis, but it does provide indirect evidence suggesting that CYP3A4 metabolizing activity may be altered in certain liver conditions, which could potentially be relevant to hydrocortisone treatment response given CYP3A4 is involved in its metabolism. However, further research is needed to establish any direct link between hydrocortisone treatment and liver cirrhosis improvement in patients with chronic liver disease associated with previous hepatic Schistosomiasis infection." -14075841,Hydrocortisone treats acute lymphoblastic leukemia,1201,"Here, we report a case of fatal ATLS complicating intrathecal injections of methotrexate, cytarabine and hydrocortisone for acute lymphoblastic leukemia which relapsed with meningeal involvement after allogeneic stem cell transplantation.",False,"Is the triple 'Hydrocortisone treats acute lymphoblastic leukemia' supported by the sentence: 'Here, we report a case of fatal ATLS complicating intrathecal injections of methotrexate, cytarabine and hydrocortisone for acute lymphoblastic leukemia which relapsed with meningeal involvement after allogeneic stem cell transplantation.'?","No, this sentence does not indirectly support the statement that hydrocortisone treats acute lymphoblastic leukemia. The sentence reports a case where hydrocortisone was used in combination with other drugs for treatment, but it does not state that hydrocortisone was effective in treating the leukemia. In fact, the leukemia relapsed, suggesting that the treatment was not successful." -13951019,Hydrocortisone treats HIV infectious disease,1202,"Except in one patient with HIV infection, all the signs and symptoms improved after antituberculous and hydrocortisone treatment.",False,"Is the triple 'Hydrocortisone treats HIV infectious disease' supported by the sentence: 'Except in one patient with HIV infection, all the signs and symptoms improved after antituberculous and hydrocortisone treatment.'?","No, this statement does not provide indirect support for hydrocortisone treating HIV infection. The sentence only mentions one patient with HIV infection who showed improvement after hydrocortisone treatment, but it does not specify what the patient was being treated for (it could have been for tuberculosis, which was also being treated). Therefore, it does not establish a direct link between hydrocortisone treatment and improvement in HIV infection." -13724762,Hydrocortisone treats severe acute respiratory syndrome,1203,"Cortisol levels are elevated in patients with RSV and Ebola, and cortisol was higher in SARS patients with lymphopenia before any steroid therapy.",False,"Is the triple 'Hydrocortisone treats severe acute respiratory syndrome' supported by the sentence: 'Cortisol levels are elevated in patients with RSV and Ebola, and cortisol was higher in SARS patients with lymphopenia before any steroid therapy.'?","No, this statement does not indirectly support the claim that hydrocortisone treats severe acute respiratory syndrome (SARS). The sentence provided discusses cortisol levels in patients with different viral infections, including SARS, RSV, and Ebola, but it does not mention hydrocortisone therapy for SARS patients specifically, nor does it establish any causal relationship between cortisol levels and SARS severity. Hydrocortisone is a synthetic form of cortisol, but administering it as a treatment for SARS is not directly supported by this information alone, as there may be other factors at play, such as potential side effects, dosage, and timing, which require further investigation to establish an effective therapy for SARS." -13691671,Hydrocortisone treats Insulin resistance,1204,OBJECTIVE: To investigate possible effects of insulin-sensitizing treatment on cortisol metabolism in insulin-resistant patients with polycystic ovary syndrome (PCOS).,False,Is the triple 'Hydrocortisone treats Insulin resistance' supported by the sentence: 'OBJECTIVE: To investigate possible effects of insulin-sensitizing treatment on cortisol metabolism in insulin-resistant patients with polycystic ovary syndrome (PCOS).'?,"No, this statement does not directly support the claim that hydrocortisone treats insulin resistance. The objective in this sentence is to investigate possible effects of insulin-sensitizing treatment on cortisol metabolism in insulin-resistant patients with polycystic ovary syndrome (PCOS). This does not mention hydrocortisone as a treatment for insulin resistance, but rather investigates its potential effects in insulin-resistant patients." -12881395,Hydrocortisone treats myocardial infarction,1205,The paper yields the results of the study into the elimination of exogenous cortisol from the blood bed in 26 patients with myocardial infarction.,False,Is the triple 'Hydrocortisone treats myocardial infarction' supported by the sentence: 'The paper yields the results of the study into the elimination of exogenous cortisol from the blood bed in 26 patients with myocardial infarction.'?,"No, this statement does not indirectly support the claim that hydrocortisone treats myocardial infarction. The sentence you provided discusses the elimination of exogenous cortisol from the blood bed in patients with myocardial infarction, not the use of hydrocortisone as a treatment. Hydrocortisone is a type of corticosteroid, but it is not explicitly mentioned in this sentence, nor does the concept of treating myocardial infarction with it." -12524121,Hydrocortisone treats neoplasm,1206,"Retinoic acid treatment controls ACTH and cortisol hyperactivity and tumor size in dogs with ACTH-secreting tumors, leading to resolution of the clinical phenotype.",False,"Is the triple 'Hydrocortisone treats neoplasm' supported by the sentence: 'Retinoic acid treatment controls ACTH and cortisol hyperactivity and tumor size in dogs with ACTH-secreting tumors, leading to resolution of the clinical phenotype.'?","No, this statement is not indirectly supported by the given sentence. The sentence mentions retinoic acid treatment, not hydrocortisone, for controlling ACTH and cortisol hyperactivity and tumor size in dogs with ACTH-secreting tumors. Hydrocortisone is a corticosteroid, while retinoic acid is a derivative of vitamin A, so they are different substances." -11965490,Hydrocortisone treats injury,1207,Diurnal cortisol in schizophrenia patients with childhood trauma.,False,Is the triple 'Hydrocortisone treats injury' supported by the sentence: 'Diurnal cortisol in schizophrenia patients with childhood trauma.'?,"No, this statement does not indirectly support that Hydrocortisone treats injuries because it does not mention Hydrocortisone being used as a treatment for injuries, nor does it provide any link to its therapeutic effects in such cases. It talks about diurnal cortisol levels in schizophrenia patients who have experienced childhood trauma, which is not related to Hydrocortisone being used as an injury treatment." -11029944,Hydrocortisone treats eye disorder,1208,Topical compound F in the treatment of anterior segment eye disease; a preliminary report.,False,Is the triple 'Hydrocortisone treats eye disorder' supported by the sentence: 'Topical compound F in the treatment of anterior segment eye disease; a preliminary report.'?,"No, this statement is not indirectly supported by the given sentence. The sentence mentions topical compound F as a treatment for anterior segment eye disease, but it does not mention any relationship to hydrocortisone or any eye disorders it might treat." -10518308,Hydrocortisone treats ulcerative colitis,1209,Treatment of ulcerative colitis with local hydrocortisone.,True,Is the triple 'Hydrocortisone treats ulcerative colitis' supported by the sentence: 'Treatment of ulcerative colitis with local hydrocortisone.'?,"Yes, this statement is indirectly supported because hydrocortisone is being used as a treatment for ulcerative colitis, which is one part of the original statement. However, it does not explicitly state that hydrocortisone is used to treat ulcers in general, which could be interpreted as part of the original statement as well." -10516843,Hydrocortisone treats diffuse alopecia areata,1210,"Alopecia areata, partialis, and totalis; treatment with cortisone, hydrocortisone and their analogs, prednisone and prednisolone.",True,"Is the triple 'Hydrocortisone treats diffuse alopecia areata' supported by the sentence: 'Alopecia areata, partialis, and totalis; treatment with cortisone, hydrocortisone and their analogs, prednisone and prednisolone.'?","Yes, this statement does indirectly support the claim that hydrocortisone can treat diffuse alopecia areata, as it mentions cortisone, prednisone, and prednisolone as treatments for alopecia areata, partialis, and totalis, which are all types of hair loss similar to diffuse alopecia areata, and hydrocortisone is an analog of cortisone, meaning it has similar properties and can be used for similar purposes." -10492262,Hydrocortisone treats osteoarthritis,1211,Phenylbutazone and compound F for osteoarthritis of the hip; a survey and clinical report.,False,Is the triple 'Hydrocortisone treats osteoarthritis' supported by the sentence: 'Phenylbutazone and compound F for osteoarthritis of the hip; a survey and clinical report.'?,"No, this statement is not indirectly supported by the given sentence. The sentence mentions phenylbutazone and compound F as treatments for osteoarthritis of the hip, but it does not mention hydrocortisone. Therefore, there is no indirect support for the statement that hydrocortisone treats osteoarthritis." -10480635,Hydrocortisone treats atopic conjunctivitis,1212,"Hydrocortisone in treatment of allergic conjunctivitis, allergic rhinitis, and bronchial asthma.",True,"Is the triple 'Hydrocortisone treats atopic conjunctivitis' supported by the sentence: 'Hydrocortisone in treatment of allergic conjunctivitis, allergic rhinitis, and bronchial asthma.'?","Yes, this statement can be seen as indirectly supportive because it suggests that hydrocortisone is used in treating allergic conditions, which includes atopic conjunctivitis (an inflammation of the eyelid), among other conditions like allergic rhinitis (inflammation of the nasal passages) and bronchial asthma (inflammation of the bronchial tubes in the lungs). However, it doesn't explicitly state that hydrocortisone is used to treat atopic conjunctivitis, hence it is indirect support." -10280121,Hydrocortisone treats melanoma,1213,"METHOD: Adrenocorticotropic hormone (ACTH), cortisol, and interleukin-6 (IL-6) plasma concentrations were measured in 14 patients with malignant melanoma at regular intervals during the first 12 weeks of IFN-alpha therapy, both immediately before and 1, 2, and 3 hours after IFN-alpha administration.",False,"Is the triple 'Hydrocortisone treats melanoma' supported by the sentence: 'METHOD: Adrenocorticotropic hormone (ACTH), cortisol, and interleukin-6 (IL-6) plasma concentrations were measured in 14 patients with malignant melanoma at regular intervals during the first 12 weeks of IFN-alpha therapy, both immediately before and 1, 2, and 3 hours after IFN-alpha administration.'?","No, this sentence does not indirectly support the statement that hydrocortisone treats melanoma. The sentence discusses a study where adrenocorticotropic hormone (ACTH), cortisol, and interleukin-6 (IL-6) plasma concentrations were measured in patients with malignant melanoma undergoing interferon-alpha therapy. It does not mention hydrocortisone or suggest any correlation between hydrocortisone treatment and melanoma. Hydrocortisone is a type of corticosteroid often used to treat inflammation, allergies, or autoimmune disorders, but there is no direct evidence in this sentence linking it to treating melanoma." -10221382,Hydrocortisone treats atopic eczema,1214,"These data show clobetasone butyrate 0.05% is more effective than 1.0% hydrocortisone in the treatment of eczema and more effective than flurandrenolone 0.0125% (p=0.01%) and a potent topical steroid hydrocortisone butyrate (p<0.05), in the treatment of psoriasis.",False,"Is the triple 'Hydrocortisone treats atopic eczema' supported by the sentence: 'These data show clobetasone butyrate 0.05% is more effective than 1.0% hydrocortisone in the treatment of eczema and more effective than flurandrenolone 0.0125% (p=0.01%) and a potent topical steroid hydrocortisone butyrate (p<0.05), in the treatment of psoriasis.'?","No, this sentence does not indirectly support the statement that hydrocortisone treats atopic eczema. The sentence compares the effectiveness of clobetasone butyrate, flurandrenolone, and hydrocortisone butyrate in treating psoriasis, not atopic eczema. It does mention hydrocortisone, but it does not provide any information about hydrocortisone's effectiveness in treating atopic eczema, which is what the original statement claims." -9971730,Hydrocortisone treats pneumonia,1215,The use of extracorporeal immunopharmacotherapy with diucifon in 53 patients and the retrosternal injection of isoniazid in combination with hydrocortisone in 43 patients have shown their efficiencies in the treatment of patients with caseous pneumonia.,False,Is the triple 'Hydrocortisone treats pneumonia' supported by the sentence: 'The use of extracorporeal immunopharmacotherapy with diucifon in 53 patients and the retrosternal injection of isoniazid in combination with hydrocortisone in 43 patients have shown their efficiencies in the treatment of patients with caseous pneumonia.'?,"No, this statement does not indirectly support the claim that hydrocortisone treats pneumonia, including caseous pneumonia, on its own, as it emphasizes the efficacy of combination therapies involving hydrocortisone, diucifon, and isoniazid in treating caseous pneumonia, rather than hydrocortisone alone." -9665107,Hydrocortisone treats prostate cancer,1216,"Therefore, a prospective phase II study was conducted to assess the efficacy and safety of a regimen of low dose (200 mg.) oral ketoconazole 3 times daily with replacement doses of hydrocortisone in men with androgen independent prostate cancer.",False,"Is the triple 'Hydrocortisone treats prostate cancer' supported by the sentence: 'Therefore, a prospective phase II study was conducted to assess the efficacy and safety of a regimen of low dose (200 mg.) oral ketoconazole 3 times daily with replacement doses of hydrocortisone in men with androgen independent prostate cancer.'?","No, this statement does not directly support the claim that hydrocortisone treats prostate cancer. The sentence mentions hydrocortisone being used in combination with ketoconazole for men with androgen independent prostate cancer, but it does not imply that hydrocortisone alone is an effective treatment for prostate cancer." -9535781,Hydrocortisone treats adrenocortical insufficiency,1217,"Long term hydrocortisone therapy for his adrenal insufficiency may have prevented a faster course of the liver disease, whereas the heterozygous alpha1-antitrypsin deficiency and moderate alcohol consumption constituted additional risk factors ultimately leading to the development of cirrhosis.",True,"Is the triple 'Hydrocortisone treats adrenocortical insufficiency' supported by the sentence: 'Long term hydrocortisone therapy for his adrenal insufficiency may have prevented a faster course of the liver disease, whereas the heterozygous alpha1-antitrypsin deficiency and moderate alcohol consumption constituted additional risk factors ultimately leading to the development of cirrhosis.'?","Yes, the statement does indirectly support the claim that hydrocortisone treats adrenocortical insufficiency. The sentence mentions that long-term hydrocortisone therapy was used for treating adrenal insufficiency, which suggests its effectiveness in managing this condition. However, it also implies that other factors like alpha1-antitrypsin deficiency and alcohol consumption contributed to the development of cirrhosis, indicating that hydrocortisone therapy may not prevent all possible complications associated with adrenal insufficiency." -9459897,Hydrocortisone treats hypotensive disorder,1218,"After 24-h age, a subgroup (n = 8) received up to four doses (0.5-1.0 mg/kg each) of hydrocortisone for refractory hypotension.",True,"Is the triple 'Hydrocortisone treats hypotensive disorder' supported by the sentence: 'After 24-h age, a subgroup (n = 8) received up to four doses (0.5-1.0 mg/kg each) of hydrocortisone for refractory hypotension.'?","Yes, this statement does provide indirect support for the claim that hydrocortisone can be used to treat hypotensive disorder, specifically refractory hypotension in this case. The sentence mentions that eight patients received hydrocortisone to treat their refractory hypotension, indicating a direct treatment relationship between hydrocortisone and hypotension, even though it doesn't explicitly state it is for treating hypotension in general." -9175521,Hydrocortisone treats type 1 diabetes mellitus,1219,"Interaction of endogenous growth hormone, cortisol, and catecholamines with blood glucose in children with brittle diabetes mellitus.",False,"Is the triple 'Hydrocortisone treats type 1 diabetes mellitus' supported by the sentence: 'Interaction of endogenous growth hormone, cortisol, and catecholamines with blood glucose in children with brittle diabetes mellitus.'?","No, this statement is not indirectly supported by the sentence provided. Hydrocortisone is a type of cortisol, but the sentence does not mention its use in treating type 1 diabetes mellitus. Instead, it discusses the interaction of endogenous growth hormone, cortisol, and catecholamines with blood glucose in children with brittle diabetes mellitus, which suggests a natural physiological process rather than a treatment approach." -8776300,Hydrocortisone treats Inflammation,1220,"Acidification with a topical solution of 2 percent acetic acid combined with hydrocortisone for inflammation is effective treatment in most cases and, when used after exposure to moisture, is an excellent prophylactic.",True,"Is the triple 'Hydrocortisone treats Inflammation' supported by the sentence: 'Acidification with a topical solution of 2 percent acetic acid combined with hydrocortisone for inflammation is effective treatment in most cases and, when used after exposure to moisture, is an excellent prophylactic.'?","Yes, this statement can indirectly support the idea that hydrocortisone treats inflammation. The sentence mentions hydrocortisone being used in combination with a topical solution to treat inflammation, which suggests its role in managing inflammatory conditions. However, it doesn't directly mention hydrocortisone treating inflammation on its own, hence the term 'indirectly'." -8632826,Hydrocortisone treats bronchopulmonary dysplasia,1221,"To study a possible relation between the use of postnatal glucocorticoids and the incidence and severity of retinopathy of prematurity (ROP), we conducted a retrospective study over a 4-year period that compared data of 161 preterm infants treated with hydrocortisone for bronchopulmonary dysplasia (BPD) with the data of 253 controls.",True,"Is the triple 'Hydrocortisone treats bronchopulmonary dysplasia' supported by the sentence: 'To study a possible relation between the use of postnatal glucocorticoids and the incidence and severity of retinopathy of prematurity (ROP), we conducted a retrospective study over a 4-year period that compared data of 161 preterm infants treated with hydrocortisone for bronchopulmonary dysplasia (BPD) with the data of 253 controls.'?","Yes, this statement does indirectly support the claim that hydrocortisone treats bronchopulmonary dysplasia (BPD). The sentence mentions a retrospective study conducted over four years, comparing data from 161 preterm infants treated with hydrocortisone for BPD to 253 control subjects, implying hydrocortisone was used as a treatment for BPD during this study period, which aligns with the claim made in the statement. However, it does not provide information on whether hydrocortisone is effective in treating BPD, so it does not directly support this claim, but rather supports it indirectly through mentioning its use as treatment for BPD in this context." -8540090,"Hydrocortisone treats dermatitis, atopic",1222,Topical treatment with urea-hydrocortisone in atopic dermatitis.,True,"Is the triple 'Hydrocortisone treats dermatitis, atopic' supported by the sentence: 'Topical treatment with urea-hydrocortisone in atopic dermatitis.'?","Yes, this statement does provide indirect support for the triple statement provided, as it mentions using hydrocortisone in conjunction with urea to treat atopic dermatitis, which is one form of dermatitis. This sentence suggests hydrocortisone can be used to treat atopic dermatitis, which is consistent with the triple statement, although it does not explicitly state it is used to treat other forms of dermatitis as well." -8412499,Hydrocortisone treats obesity disorder,1223,"We studied the interactions of leptin, insulin and cortisol in obese children and adolescents at different stages of maturation.",False,"Is the triple 'Hydrocortisone treats obesity disorder' supported by the sentence: 'We studied the interactions of leptin, insulin and cortisol in obese children and adolescents at different stages of maturation.'?","No, this statement does not indirectly support the idea that hydrocortisone treats obesity disorder. The sentence provided discusses a study on the interactions of leptin, insulin, and cortisol in obese children and adolescents at different stages of maturation, but it does not mention hydrocortisone being used as a treatment for obesity disorder. Hydrocortisone is a type of corticosteroid, which could be related to cortisol, but this statement does not provide evidence for hydrocortisone as a treatment for obesity." -8248241,Hydrocortisone treats Sepsis,1224,[Cortisol in critically ill patients with sepsis: physiologic functions and therapeutic implications].,True,Is the triple 'Hydrocortisone treats Sepsis' supported by the sentence: '[Cortisol in critically ill patients with sepsis: physiologic functions and therapeutic implications].'?,"Yes, this is indirectly supported. The sentence mentions Cortisol in critically ill patients with sepsis, and Hydrocortisone is a synthetic form of Cortisol, which is often used in treating sepsis due to its anti-inflammatory effects. However, it's important to note that while Hydrocortisone may be used in treating sepsis, it is not a direct treatment for sepsis itself, but rather for managing some of the symptoms associated with it." -8061437,Hydrocortisone treats congenital adrenal hyperplasia,1225,"We conclude that the regimen of flutamide, testolactone, reduced hydrocortisone dose, and fludrocortisone provides effective control of congenital adrenal hyperplasia with reduced risk of glucocorticoid excess.",True,"Is the triple 'Hydrocortisone treats congenital adrenal hyperplasia' supported by the sentence: 'We conclude that the regimen of flutamide, testolactone, reduced hydrocortisone dose, and fludrocortisone provides effective control of congenital adrenal hyperplasia with reduced risk of glucocorticoid excess.'?","Yes, this statement does indirectly support the claim that hydrocortisone can be used to treat congenital adrenal hyperplasia (CAH). The sentence mentions a regimen for treating CAH, which includes reduced hydrocortisone dose as part of its components, along with flutamide, testolactone, and fludrocortisone. This suggests that hydrocortisone, even at reduced doses, is still considered as part of an effective treatment regimen for CAH, thus supporting its use in treating this condition. However, this statement does not directly demonstrate hydrocortisone treating CAH on its own, but rather in combination with other medications, which is consistent with real-world clinical scenarios where combinations of medications might be used to effectively treat complex conditions such as CAH." -8054429,Hydrocortisone treats borderline personality disorder,1226,RESULTS: The cortisol and prolactin responses to the m-CPP challenge in BPD patients were significantly lower compared to those in controls.,False,Is the triple 'Hydrocortisone treats borderline personality disorder' supported by the sentence: 'RESULTS: The cortisol and prolactin responses to the m-CPP challenge in BPD patients were significantly lower compared to those in controls.'?,"No, this statement does not indirectly support the idea that Hydrocortisone treats borderline personality disorder (BPD). The result mentioned is about cortisol and prolactin responses to a m-CPP challenge in BPD patients, but it does not relate to Hydrocortisone treatment. Hydrocortisone is a glucocorticoid used to treat conditions like adrenal insufficiency, inflammation, allergies, and skin conditions, among others, but not specifically BPD." -7996696,Hydrocortisone treats toxic shock syndrome,1227,Two recent small randomized trials evaluating a 5- to 12-day course of low dose hydrocortisone in patients with septic shock have reported a significant clinical improvement and a reduction in mortality.,True,Is the triple 'Hydrocortisone treats toxic shock syndrome' supported by the sentence: 'Two recent small randomized trials evaluating a 5- to 12-day course of low dose hydrocortisone in patients with septic shock have reported a significant clinical improvement and a reduction in mortality.'?,"Yes, the statement is indirectly supported. The sentence mentioned two recent randomized trials where low-dose hydrocortisone administration in patients suffering from septic shock led to significant clinical improvement and reduced mortality rates. Toxic Shock Syndrome is an acute illness caused by toxin-producing bacteria, which can lead to sepsis, also known as septic shock in severe cases. Since hydrocortisone has been shown to improve clinical outcomes in patients with septic shock, it could potentially benefit those suffering from Toxic Shock Syndrome as well, even though it was not explicitly studied in those cases." -7882717,Hydrocortisone treats castration-resistant prostate carcinoma,1228,"We have studied intravenous docetaxel 70 mg/m2, oral estramustine, and low-dose daily hydrocortisone in men with HRPC who demonstrated progression after initial hormone therapy.",True,"Is the triple 'Hydrocortisone treats castration-resistant prostate carcinoma' supported by the sentence: 'We have studied intravenous docetaxel 70 mg/m2, oral estramustine, and low-dose daily hydrocortisone in men with HRPC who demonstrated progression after initial hormone therapy.'?","Yes, this statement does indirectly support the claim that hydrocortisone can be used to treat castration-resistant prostate carcinoma (HRPC). The sentence mentions the use of hydrocortisone in combination with intravenous docetaxel and oral estramustine for men with HRPC who have shown progression after initial hormone therapy. While it doesn't explicitly state that hydrocortisone directly treats HRPC, it does suggest its use in managing this condition as part of a treatment regimen, which implies its potential therapeutic value in this context." -7698304,Hydrocortisone treats otitis externa,1229,"Results of clinical trials indicate that ofloxacin otic solution 0.3% is as effective as topical neomycin/polymixin B/hydrocortisone preparations in the treatment of otitis externa (clinical cure rate >80% in adults and >95% in children for both treatments) and oral amoxicillin/clavulanic acid in the treatment of otitis media in the presence of tympanostomy tubes in children (clinical cure rates 76 and 69% for ofloxacin and amoxicillin/clavulanic acid, respectively).",False,"Is the triple 'Hydrocortisone treats otitis externa' supported by the sentence: 'Results of clinical trials indicate that ofloxacin otic solution 0.3% is as effective as topical neomycin/polymixin B/hydrocortisone preparations in the treatment of otitis externa (clinical cure rate >80% in adults and >95% in children for both treatments) and oral amoxicillin/clavulanic acid in the treatment of otitis media in the presence of tympanostomy tubes in children (clinical cure rates 76 and 69% for ofloxacin and amoxicillin/clavulanic acid, respectively).'?","No, this sentence does not indirectly support the statement ""Hydrocortisone treats otitis externa"". The sentence mentions hydrocortisone as part of a topical preparation for treating otitis externa, but it does not specify that hydrocortisone is responsible for treating otitis externa. It only states that hydrocortisone is part of an effective treatment when used in combination with other substances, not as a standalone treatment." -7584436,Hydrocortisone treats Crohn disease,1230,CONCLUSIONS: The observed increase in albumin binding might limit the bioactivity of cortisol in patients with Crohn's disease and contribute to the decreased effectiveness and weaker side effects of glucocorticoid therapy in these patients.,True,Is the triple 'Hydrocortisone treats Crohn disease' supported by the sentence: 'CONCLUSIONS: The observed increase in albumin binding might limit the bioactivity of cortisol in patients with Crohn's disease and contribute to the decreased effectiveness and weaker side effects of glucocorticoid therapy in these patients.'?,"Yes, the statement is indirectly supported by this sentence. Hydrocortisone is a type of corticosteroid, similar to cortisol, which is used to treat inflammatory bowel diseases like Crohn's disease. The sentence suggests that increased albumin binding might limit the bioactivity of cortisol in patients with Crohn's disease, which could imply that hydrocortisone, being similar to cortisol, might also be less effective in these patients due to increased albumin binding. However, this is an indirect inference and would need further research to confirm." -7432481,Hydrocortisone treats pancreatitis,1231,"The amount of N-acetyl D-glucosamine in the zymogen granule membrane was not altered by caerulein acute pancreatitis induced under continuous hydrocortisone treatment, but it was decreased by the administration of L-364,718 over 7 days after pancreatitis induction.",False,"Is the triple 'Hydrocortisone treats pancreatitis' supported by the sentence: 'The amount of N-acetyl D-glucosamine in the zymogen granule membrane was not altered by caerulein acute pancreatitis induced under continuous hydrocortisone treatment, but it was decreased by the administration of L-364,718 over 7 days after pancreatitis induction.'?","No, this statement does not support the claim that hydrocortisone treats pancreatitis. The sentence provided discusses the effects of hydrocortisone on N-acetyl D-glucosamine levels in zymogen granule membranes in relation to caerulein-induced acute pancreatitis, but it does not provide evidence for a therapeutic effect of hydrocortisone on pancreatitis itself." -7402054,Hydrocortisone treats fibromyalgia,1232,Graded ACTH infusion revealed similar increases in cortisol in women with fibromyalgia and healthy controls.,False,Is the triple 'Hydrocortisone treats fibromyalgia' supported by the sentence: 'Graded ACTH infusion revealed similar increases in cortisol in women with fibromyalgia and healthy controls.'?,"No, this statement does not provide indirect support for the claim that Hydrocortisone, which is a type of ACTH (Adrenocorticotropic hormone), treats fibromyalgia. The sentence only mentions that there is no difference in cortisol response between women with fibromyalgia and healthy controls when given ACTH, but it does not mention any therapeutic effect of Hydrocortisone on fibromyalgia." -7378370,Hydrocortisone treats chronic primary adrenal insufficiency,1233,The effects of endogenous opioids and cortisol on thyrotropin and prolactin secretion in patients with Addison's disease.,True,Is the triple 'Hydrocortisone treats chronic primary adrenal insufficiency' supported by the sentence: 'The effects of endogenous opioids and cortisol on thyrotropin and prolactin secretion in patients with Addison's disease.'?,"Yes, this statement can be seen as indirectly supportive, as it mentions both cortisol (which is what Hydrocortisone replaces in cases of adrenal insufficiency) and its effects on hormonal secretion in patients with Addison's disease, which is a form of chronic primary adrenal insufficiency. However, it does not directly mention Hydrocortisone, so it is an indirect association at best." -7363431,Hydrocortisone treats asthma,1234,[Dynamics of the cortisol content in the blood plasma in specific hyposensibilization in children with bronchial asthma].,False,Is the triple 'Hydrocortisone treats asthma' supported by the sentence: '[Dynamics of the cortisol content in the blood plasma in specific hyposensibilization in children with bronchial asthma].'?,"No, this statement is not indirectly supported by the given sentence. The sentence discusses cortisol content in blood plasma in relation to hyposensibilization in children with bronchial asthma, not hydrocortisone, which is a synthetic form of cortisol, not cortisol itself. Furthermore, it discusses hyposensibilization, not treatment, which implies a different medical approach to managing asthma symptoms." -27127545,Methylprednisolone treats lymphoproliferative syndrome,1235,Treatment of X-linked lymphoproliferative disease (Duncan disease) with high-dose methylprednisolone and etoposide (VP-16).,True,Is the triple 'Methylprednisolone treats lymphoproliferative syndrome' supported by the sentence: 'Treatment of X-linked lymphoproliferative disease (Duncan disease) with high-dose methylprednisolone and etoposide (VP-16).'?,"Yes, this statement can be seen as indirectly supportive of the original claim, as methylprednisolone is mentioned as part of the treatment for X-linked lymphoproliferative disease, which is a type of lymphoproliferative syndrome. However, it should be noted that this does not directly confirm that methylprednisolone is an effective treatment for all types of lymphoproliferative syndromes, as X-linked lymphoproliferative disease is a specific condition with its own characteristics." -26450412,Methylprednisolone treats leukemia,1236,"Circadian optimization of the treatment of L1210 leukemia with 1-beta-D-arabinofuranosylcytosine, cyclophosphamide, vincristine and methylprednisolone.",False,"Is the triple 'Methylprednisolone treats leukemia' supported by the sentence: 'Circadian optimization of the treatment of L1210 leukemia with 1-beta-D-arabinofuranosylcytosine, cyclophosphamide, vincristine and methylprednisolone.'?","No, this sentence does not support the claim that Methylprednisolone treats leukemia, even indirectly. The sentence only mentions that Methylprednisolone is part of a treatment regimen for L1210 leukemia, but it does not imply that Methylprednisolone is responsible for treating leukemia. The other drugs in the regimen (1-beta-D-arabinofuranosylcytosine, cyclophosphamide, vincristine) could also be contributing to the treatment effect." -26339812,Methylprednisolone treats alcoholic hepatitis,1237,Controlled trial of methylprednisolone therapy in severe acute alcoholic hepatitis.,True,Is the triple 'Methylprednisolone treats alcoholic hepatitis' supported by the sentence: 'Controlled trial of methylprednisolone therapy in severe acute alcoholic hepatitis.'?,"Yes, this is indirectly supported. The controlled trial mentioned in the sentence suggests that methylprednisolone was studied as a potential treatment for severe acute alcoholic hepatitis, implying that it is at least theoretically used for treating this condition, which aligns with the statement 'Methylprednisolone treats alcoholic hepatitis'. However, it is essential to note that this does not imply direct causation, as further research is required to establish the efficacy and safety of such treatment." -26307075,Methylprednisolone treats psoriatic arthritis,1238,"1 The present study was undertaken to characterize the spectrum of arachidonic acid metabolites present in synovial effusions of patients with rheumatoid or psoriatic arthritis, and to compare changes in their concentration following a short-term treatment with 6alpha-methyl-prednisolone (6-MeP: 4-8 mg/day) or indoprofen (1.2 g/day), a nonsteroidal anti-inflammatory agent with proven synovial prostaglandin inhibitory effect.2 Measurements of prostaglandin E(2) (PGE(2)), thromboxane (TX) B(2), 6-keto-PGF(1alpha) and PGF(2alpha) were performed by radioimmunoassay techniques in synovial effusions obtained from 23 patients, and validated by thin-layer chromatographic analysis of the extracted immunoreactivity.3 PGE(2) and TXB(2) accounted for more than 60% of the total immunoreactivity in untreated patients.",False,"Is the triple 'Methylprednisolone treats psoriatic arthritis' supported by the sentence: '1 The present study was undertaken to characterize the spectrum of arachidonic acid metabolites present in synovial effusions of patients with rheumatoid or psoriatic arthritis, and to compare changes in their concentration following a short-term treatment with 6alpha-methyl-prednisolone (6-MeP: 4-8 mg/day) or indoprofen (1.2 g/day), a nonsteroidal anti-inflammatory agent with proven synovial prostaglandin inhibitory effect.2 Measurements of prostaglandin E(2) (PGE(2)), thromboxane (TX) B(2), 6-keto-PGF(1alpha) and PGF(2alpha) were performed by radioimmunoassay techniques in synovial effusions obtained from 23 patients, and validated by thin-layer chromatographic analysis of the extracted immunoreactivity.3 PGE(2) and TXB(2) accounted for more than 60% of the total immunoreactivity in untreated patients.'?","No, this sentence does not indirectly support that Methylprednisolone treats psoriatic arthritis. The sentence discusses a study characterizing arachidonic acid metabolites in synovial effusions of patients with rheumatoid or psoriatic arthritis, before and after treatment with 6alpha-methyl-prednisolone (6-MeP) or indoprofen, but it does not provide any information about the effectiveness of 6-MeP in treating psoriatic arthritis." -26279366,Methylprednisolone treats angioimmunoblastic T-cell lymphoma,1239,Pulse methylprednisolone therapy in angioimmunoblastic lymphadenopathy.,True,Is the triple 'Methylprednisolone treats angioimmunoblastic T-cell lymphoma' supported by the sentence: 'Pulse methylprednisolone therapy in angioimmunoblastic lymphadenopathy.'?,"Yes, this statement can be interpreted as indirectly supporting the claim that Methylprednisolone is used to treat angioimmunoblastic T-cell lymphoma (a type of lymphadenopathy). The term ""pulse methylprednisolone therapy"" suggests the use of Methylprednisolone as a treatment for some form of lymphadenopathy, which includes angioimmunoblastic T-cell lymphoma. However, it does not directly state that Methylprednisolone is used specifically for this type of lymphadenopathy, hence it is indirect support." -25738014,Methylprednisolone treats ankylosing spondylitis,1240,Seven patients with active AS and insufficient efficacy of NSAID for three months were treated with one gram methylprednisolone daily given intravenously for three successive days.,False,Is the triple 'Methylprednisolone treats ankylosing spondylitis' supported by the sentence: 'Seven patients with active AS and insufficient efficacy of NSAID for three months were treated with one gram methylprednisolone daily given intravenously for three successive days.'?,"No, this statement does not indirectly support the claim that Methylprednisolone treats Ankylosing Spondylitis (AS). The statement mentions that seven patients with active AS were treated with Methylprednisolone, but it does not provide any information about the efficacy of this treatment for AS, which is necessary to infer any supportive relationship between Methylprednisolone as a treatment for AS." -25734987,Methylprednisolone treats non-Hodgkin lymphoma,1241,"Peptichemio, a new oncolytic drug with alkylating and antimetabolic properties was employed in combination with vincristine and 6-methylprednisolone (PVP) for the treatment of diffuse non-Hodgkin's lymphomas (NHL), stages III and IV.",False,"Is the triple 'Methylprednisolone treats non-Hodgkin lymphoma' supported by the sentence: 'Peptichemio, a new oncolytic drug with alkylating and antimetabolic properties was employed in combination with vincristine and 6-methylprednisolone (PVP) for the treatment of diffuse non-Hodgkin's lymphomas (NHL), stages III and IV.'?","No, this statement does not indirectly support that Methylprednisolone treats non-Hodgkin lymphoma. The sentence mentioned only specifies 6-methylprednisolone, which is different from Methylprednisolone, as it has an additional 6- carbon atom in its structure. Therefore, it cannot be inferred that Methylprednisolone, without the 6-, is used in treating non-Hodgkin lymphoma based on this sentence alone." -25642231,Methylprednisolone treats heart disorder,1242,High-dose MP may be contraindicated in patients with known heart disease.,True,Is the triple 'Methylprednisolone treats heart disorder' supported by the sentence: 'High-dose MP may be contraindicated in patients with known heart disease.'?,"Yes, this is indirectly supported. The sentence ""High-dose MP may be contraindicated in patients with known heart disease."" suggests that Methylprednisolone (MP) could have potential adverse effects on patients with heart disease, which implies that it could be used in treating heart disorders, albeit indirectly through managing complications or side effects from high-dose usage. However, it is important to note that this does not imply Methylprednisolone is a primary treatment for heart disorders, but rather it may have an indirect role in managing certain aspects related to these conditions in specific contexts, such as high-dose usage scenarios where complications arise for patients with known heart disease." -25366540,Methylprednisolone treats myopathy,1243,PURPOSE: To report the therapeutic efficacy of intravenous methylprednisolone (IVMP) in patients with restrictive myopathy caused by thyroid eye disease (TED).,True,Is the triple 'Methylprednisolone treats myopathy' supported by the sentence: 'PURPOSE: To report the therapeutic efficacy of intravenous methylprednisolone (IVMP) in patients with restrictive myopathy caused by thyroid eye disease (TED).'?,"Yes, the sentence does indirectly support the statement that Methylprednisolone treats myopathy. The sentence mentions that Methylprednisolone is used therapeutically in patients with restrictive myopathy caused by thyroid eye disease (TED). This suggests that Methylprednisolone has some efficacy in treating myopathy, even if it is specific to myopathy caused by TED. However, it is important to note that this does not necessarily mean that Methylprednisolone would be effective in treating all types of myopathy, as different forms may have different underlying causes and therefore require different treatments." -24273559,Methylprednisolone treats Abdominal pain,1244,"After 2 months of treatment with systemic methylprednisolone, cyclophosphamide, and prednisone, the patient's abdominal pain was relieved.",True,"Is the triple 'Methylprednisolone treats Abdominal pain' supported by the sentence: 'After 2 months of treatment with systemic methylprednisolone, cyclophosphamide, and prednisone, the patient's abdominal pain was relieved.'?","Yes, this statement can be seen as indirectly supportive of the claim that Methylprednisolone can treat abdominal pain. The sentence indicates that after two months of treatment with Methylprednisolone, among other medications, the patient's abdominal pain was relieved. However, it should be noted that this is an indirect inference, as the sentence does not directly state that Methylprednisolone alone was responsible for relieving the abdominal pain. Other factors, such as the combination of medications or the natural progression of the patient's condition, could also have contributed to the pain relief." -23772707,Methylprednisolone treats cardiac arrest,1245,Effect of Vasopressin and Methylprednisolone vs Placebo on Return of Spontaneous Circulation in Patients With In-Hospital Cardiac Arrest: A Randomized Clinical Trial.,False,Is the triple 'Methylprednisolone treats cardiac arrest' supported by the sentence: 'Effect of Vasopressin and Methylprednisolone vs Placebo on Return of Spontaneous Circulation in Patients With In-Hospital Cardiac Arrest: A Randomized Clinical Trial.'?,"No, this statement is not supported by the provided sentence. The sentence describes a randomized clinical trial investigating the effect of vasopressin, methylprednisolone, and placebo on return of spontaneous circulation in patients with in-hospital cardiac arrest, but it does not claim or imply that methylprednisolone specifically treats cardiac arrest." -23209303,Methylprednisolone treats respiratory system disorder,1246,"Although methylprednisolone gradually improved her respiratory condition, her oxygenation and exercise tolerance had drastically deteriorated, necessitating high-flow nasal cannula oxygen therapy.",False,"Is the triple 'Methylprednisolone treats respiratory system disorder' supported by the sentence: 'Although methylprednisolone gradually improved her respiratory condition, her oxygenation and exercise tolerance had drastically deteriorated, necessitating high-flow nasal cannula oxygen therapy.'?","No, this statement does not provide direct evidence to support the claim that Methylprednisolone treats respiratory system disorders. The sentence only indicates that Methylprednisolone improved her condition gradually, but it did not prevent her condition from deteriorating to the point where she needed high-flow nasal cannula oxygen therapy. Therefore, it does not demonstrate that Methylprednisolone is an effective treatment for respiratory system disorders." -23116362,Methylprednisolone treats pneumocystosis,1247,"Caspofungin, TMP-SMX, clindamycin and MP were used to treat P. jirovecii pneumonia (PJP).",True,"Is the triple 'Methylprednisolone treats pneumocystosis' supported by the sentence: 'Caspofungin, TMP-SMX, clindamycin and MP were used to treat P. jirovecii pneumonia (PJP).'?","Yes, this statement does indirectly support the claim that Methylprednisolone (MP) is used to treat Pneumocystosis (PJP). Caspofungin, TMP-SMX, clindamycin, and MP were all used to treat PJP, which implies MP is also used for this purpose, even though it is not directly stated in the sentence. However, it is important to note that Methylprednisolone is typically used to manage the inflammatory response associated with PJP rather than treating the infection itself, which is addressed by antifungal medications like Caspofungin, TMP-SMX, and clindamycin." -22495912,Methylprednisolone treats myocarditis,1248,"Although, not described in the literature, we have found conjunctive use of milrinone and methylprednisolone effective in patient with SARS-CoV-2 fulminant myocarditis.",True,"Is the triple 'Methylprednisolone treats myocarditis' supported by the sentence: 'Although, not described in the literature, we have found conjunctive use of milrinone and methylprednisolone effective in patient with SARS-CoV-2 fulminant myocarditis.'?","Yes, this sentence can indirectly support the statement that Methylprednisolone can be used to treat myocarditis, specifically in conjunction with milrinone for SARS-CoV-2 fulminant myocarditis. The sentence suggests a positive outcome when using these two treatments together, which implies that Methylprednisolone is beneficial in treating this specific type of myocarditis, even if it is not explicitly mentioned in literature at the time. However, it is important to note that this evidence is limited to SARS-CoV-2 fulminant myocarditis cases, so further research would be needed to generalize this finding to all types of myocarditis." -19962298,Methylprednisolone treats Hodgkins lymphoma,1249,High incidence of aseptic hip necrosis in Hodgkin lymphoma patients treated with escalated BEACOPP receiving methylprednisolone.,False,Is the triple 'Methylprednisolone treats Hodgkins lymphoma' supported by the sentence: 'High incidence of aseptic hip necrosis in Hodgkin lymphoma patients treated with escalated BEACOPP receiving methylprednisolone.'?,"No, this statement does not indirectly support the claim that Methylprednisolone treats Hodgkin lymphoma. The sentence provided mentions the high incidence of aseptic hip necrosis in Hodgkin lymphoma patients treated with escalated BEACOPP (a chemotherapy regimen) including methylprednisolone. This suggests a side effect of methylprednisolone when used in this context, not a therapeutic effect." -19674675,Methylprednisolone treats microscopic polyangiitis,1250,Six newly diagnosed patients with MPA were initially treated with methylprednisolone and a single dose of RTX (375 mg/m2).,False,Is the triple 'Methylprednisolone treats microscopic polyangiitis' supported by the sentence: 'Six newly diagnosed patients with MPA were initially treated with methylprednisolone and a single dose of RTX (375 mg/m2).'?,"No, this sentence does not indirectly support the statement that Methylprednisolone treats microscopic polyangiitis (MPA). The sentence only mentions that methylprednisolone was used as an initial treatment for newly diagnosed MPA patients, but it does not provide any information about its therapeutic effect on MPA." -19534575,Methylprednisolone treats anterior ischemic optic neuropathy,1251,Early Methylprednisolone Treatment Can Stabilize the Blood-Optic Nerve Barrier in a Rat Model of Anterior Ischemic Optic Neuropathy (rAION).,True,Is the triple 'Methylprednisolone treats anterior ischemic optic neuropathy' supported by the sentence: 'Early Methylprednisolone Treatment Can Stabilize the Blood-Optic Nerve Barrier in a Rat Model of Anterior Ischemic Optic Neuropathy (rAION).'?,"Yes, this statement could provide indirect support for the idea that Methylprednisolone treats anterior ischemic optic neuropathy (AION). The sentence states that early Methylprednisolone treatment can stabilize the blood-optic nerve barrier in a rat model of rAION. This suggests that Methylprednisolone has some beneficial effect on AION in this animal model, implying potential therapeutic value for treating AION in humans, although more research would be needed to confirm this hypothesis." -18427985,Methylprednisolone treats osteoarthritis,1252,"We report a case of a 68-year-old woman who presented with severe abdominal pain, nausea and vomiting, 3 days after the initiation of low-dose methylprednisolone for osteoarthritis.",True,"Is the triple 'Methylprednisolone treats osteoarthritis' supported by the sentence: 'We report a case of a 68-year-old woman who presented with severe abdominal pain, nausea and vomiting, 3 days after the initiation of low-dose methylprednisolone for osteoarthritis.'?","Yes, this sentence indirectly supports the statement that methylprednisolone is used to treat osteoarthritis, as it mentions the use of low-dose methylprednisolone for this purpose in a patient, who then experienced certain side effects. However, it does not directly support the effectiveness of methylprednisolone in treating osteoarthritis, nor does it mention any positive effects resulting from its use, which is what the original statement implies." -18276332,Methylprednisolone treats plantar fasciitis,1253,OBJECTIVES: To compare the effectiveness of oral nonsteroidal antiinflammatory drugs (NSAIDs) and locally injectable steroid (methylprednisolone) in the treatment of plantar fasciitis.,False,Is the triple 'Methylprednisolone treats plantar fasciitis' supported by the sentence: 'OBJECTIVES: To compare the effectiveness of oral nonsteroidal antiinflammatory drugs (NSAIDs) and locally injectable steroid (methylprednisolone) in the treatment of plantar fasciitis.'?,"No, this statement does not indirectly support that Methylprednisolone treats plantar fasciitis. The sentence only mentions that Methylprednisolone is being compared for its effectiveness in treating plantar fasciitis, but it does not confirm that it is a treatment." -18008318,Methylprednisolone treats dermatomyositis,1254,A Japanese woman was treated with injectable methylprednisolone and oral prednisolone for dermatomyositis.,True,Is the triple 'Methylprednisolone treats dermatomyositis' supported by the sentence: 'A Japanese woman was treated with injectable methylprednisolone and oral prednisolone for dermatomyositis.'?,"Yes, this sentence does indirectly support the statement that Methylprednisolone can be used to treat Dermatomyositis, as it mentions a patient being treated with injectable Methylprednisolone for this condition. However, it should be noted that it also mentions oral Prednisolone, suggesting that both drugs may be used in treatment, not necessarily Methylprednisolone alone." -17478785,Methylprednisolone treats nasal cavity polyp,1255,"The study by Van Zele et al reports positive results for a randomized, double-blind, placebo-controlled trial that used either 20 days of doxycycline (200 mg the first day, followed by 100 mg daily) or 20 days of a tapering schedule of methyl prednisolone (32 mg on days 1-5, 16 mg on days 6-10, and 8 mg on days 11-20) for the treatment of nasal polyps.",True,"Is the triple 'Methylprednisolone treats nasal cavity polyp' supported by the sentence: 'The study by Van Zele et al reports positive results for a randomized, double-blind, placebo-controlled trial that used either 20 days of doxycycline (200 mg the first day, followed by 100 mg daily) or 20 days of a tapering schedule of methyl prednisolone (32 mg on days 1-5, 16 mg on days 6-10, and 8 mg on days 11-20) for the treatment of nasal polyps.'?","Yes, this sentence does indirectly support the statement that Methylprednisolone can be used to treat nasal polyps. The sentence describes a study conducted by Van Zele et al, which was designed as a randomized, double-blind, placebo-controlled trial to evaluate two different treatment regimens for nasal polyps – doxycycline and methyl prednisolone (a type of corticosteroid). The results showed positive outcomes for both treatments, suggesting their efficacy in treating nasal polyps, methylprednisolone being one of them. However, it is important to note that this statement is based on an indirect inference, as the sentence does not explicitly state that methylprednisolone is used to treat nasal polyps, but rather implies it as part of the study results." -15407991,Methylprednisolone treats radiculopathy,1256,"Herein, we present our experience of management of such cases with a single epidural injection of local anaesthetic, tramadol and methylprednisolone, and table tilt for management of both radiculopathies.",True,"Is the triple 'Methylprednisolone treats radiculopathy' supported by the sentence: 'Herein, we present our experience of management of such cases with a single epidural injection of local anaesthetic, tramadol and methylprednisolone, and table tilt for management of both radiculopathies.'?","Yes, this statement does indirectly support the triple claim ""Methylprednisolone treats radiculopathy"". The sentence provided mentions methylprednisolone as part of an epidural injection used to manage cases, which includes managing radiculopathies, suggesting methylprednisolone has some therapeutic role in treating this condition. However, it should be noted that this is an indirect inference based on an observational study, not a direct causal link established through controlled clinical trials, which would be needed to definitively support such a claim." -14897628,Methylprednisolone treats neuromyelitis optica,1257,Early high-dose intravenous methylprednisolone is effective in preserving retinal nerve fiber layer thickness in patients with neuromyelitis optica.,True,Is the triple 'Methylprednisolone treats neuromyelitis optica' supported by the sentence: 'Early high-dose intravenous methylprednisolone is effective in preserving retinal nerve fiber layer thickness in patients with neuromyelitis optica.'?,"Yes, this sentence at least indirectly supports the statement that Methylprednisolone treats neuromyelitis optica. The sentence suggests that high-dose intravenous Methylprednisolone is effective in preserving retinal nerve fiber layer thickness in patients with neuromyelitis optica, implying a positive effect on the disease course, which aligns with the treatment concept for neuromyelitis optica." -14825096,Methylprednisolone treats West syndrome,1258,The authors report their experience with intravenous methylprednisolone for the treatment of infantile spasms.,True,Is the triple 'Methylprednisolone treats West syndrome' supported by the sentence: 'The authors report their experience with intravenous methylprednisolone for the treatment of infantile spasms.'?,"Yes, this statement can be seen as indirectly supportive because it mentions the use of intravenous methylprednisolone for treating infantile spasms, which is another term for West syndrome. However, it doesn't directly state that methylprednisolone is effective for treating West syndrome, but it does suggest its use in a similar context." -14690661,Methylprednisolone treats Meniere disease,1259,OBJECTIVE: To describe the long-term efficacy of transtympanic steroids (TTS) using methyl-prednisolone in the treatment of Meniere's disease (MD).,True,Is the triple 'Methylprednisolone treats Meniere disease' supported by the sentence: 'OBJECTIVE: To describe the long-term efficacy of transtympanic steroids (TTS) using methyl-prednisolone in the treatment of Meniere's disease (MD).'?,"Yes, this statement is at least indirectly supported by the provided sentence, which mentions an objective to describe the long-term efficacy of transtympanic steroids (TTS) using methyl-prednisolone in treating Meniere's disease (MD). The statement suggests that methylprednisolone is used in treating Meniere disease, which aligns with the objective described in the sentence. However, it does not directly prove that methylprednisolone treats Meniere disease, as it could also be used in other aspects such as symptom relief, which is not specified in the sentence." -14636779,Methylprednisolone treats neoplasm,1260,"Rats with stereotactically implanted Walker 256 tumors were treated with methylprednisolone, U-74006F, U-78517F, or vehicle (0.05 N HCl) on Days 6 through 10 following implantation.",False,"Is the triple 'Methylprednisolone treats neoplasm' supported by the sentence: 'Rats with stereotactically implanted Walker 256 tumors were treated with methylprednisolone, U-74006F, U-78517F, or vehicle (0.05 N HCl) on Days 6 through 10 following implantation.'?","No, this sentence does not indirectly support the statement that Methylprednisolone treats neoplasm (a type of tumor). The sentence only mentions that rats with Walker 256 tumors were treated with Methylprednisolone, but it does not provide any information about the outcome of the treatment or whether the tumors were reduced, removed, or controlled in any way. Therefore, it does not imply that Methylprednisolone is effective in treating tumors." -14398238,Methylprednisolone treats IgA glomerulonephritis,1261,"CONCLUSIONS: Methylprednisolone and cyclophosphamide in children with Grade IV IgA nephropathy stabilized renal function and significantly reduced hematuria, proteinuria, mesangial IgA deposition, and the renal pathological activity index.",True,"Is the triple 'Methylprednisolone treats IgA glomerulonephritis' supported by the sentence: 'CONCLUSIONS: Methylprednisolone and cyclophosphamide in children with Grade IV IgA nephropathy stabilized renal function and significantly reduced hematuria, proteinuria, mesangial IgA deposition, and the renal pathological activity index.'?","Yes, this statement is indirectly supported by the sentence provided. The sentence mentions that Methylprednisolone, when used in conjunction with cyclophosphamide, stabilized renal function and significantly reduced hematuria, proteinuria, mesangial IgA deposition, and the renal pathological activity index in children with Grade IV IgA nephropathy. This suggests that Methylprednisolone has a positive effect on treating IgA glomerulonephritis, which is what the original statement implies." -14232595,Methylprednisolone treats membranous glomerulonephritis,1262,"MN was treated with methylprednisolone as first-line therapy, then she was changed to rituximab for a relapse.",True,"Is the triple 'Methylprednisolone treats membranous glomerulonephritis' supported by the sentence: 'MN was treated with methylprednisolone as first-line therapy, then she was changed to rituximab for a relapse.'?","Yes, this statement does indirectly support the claim that Methylprednisolone can be used to treat membranous glomerulonephritis (MN). The sentence states that MN was initially treated with methylprednisolone, implying that it was used as a therapeutic agent for this condition. However, it does not directly state that methylprednisolone is effective for MN, only that it was used as a first-line therapy. The subsequent mention of rituximab suggests that the patient had a relapse, but it does not negate the fact that methylprednisolone was used as a treatment for MN." -14027935,Methylprednisolone treats diffuse large B-cell lymphoma,1263,"This study evaluated the influence of prior exposure to rituximab on response rates and survival in patients with diffuse large B-cell lymphoma treated with rituximab plus etoposide, cytarabine, cisplatinum and methylprednisolone (R-ESHAP).",False,"Is the triple 'Methylprednisolone treats diffuse large B-cell lymphoma' supported by the sentence: 'This study evaluated the influence of prior exposure to rituximab on response rates and survival in patients with diffuse large B-cell lymphoma treated with rituximab plus etoposide, cytarabine, cisplatinum and methylprednisolone (R-ESHAP).'?","No, this statement does not indirectly support the claim that Methylprednisolone treats diffuse large B-cell lymphoma. The sentence you provided discusses a study where methylprednisolone is part of a treatment regimen (R-ESHAP) for diffuse large B-cell lymphoma, but it does not confirm that methylprednisolone alone has any therapeutic effect on this type of lymphoma." -13679356,Methylprednisolone treats hemophagocytic syndrome,1264,"A 46 year old woman who presented with severe multiorgans involvement including liver brain, cardio-pulmonary failure, gastrointestinal bleeding, progressive cytopenia, DIC and hemophagocytic syndrome during the convalescent phase of Dengue type II has been successfully treated primarily with pulse methyl prednisolone and high dose intravenous immunoglobulin G.",True,"Is the triple 'Methylprednisolone treats hemophagocytic syndrome' supported by the sentence: 'A 46 year old woman who presented with severe multiorgans involvement including liver brain, cardio-pulmonary failure, gastrointestinal bleeding, progressive cytopenia, DIC and hemophagocytic syndrome during the convalescent phase of Dengue type II has been successfully treated primarily with pulse methyl prednisolone and high dose intravenous immunoglobulin G.'?","Yes, this sentence does indirectly support the statement that Methylprednisolone can treat Hemophagocytic syndrome in at least one case. The sentence describes a patient who was treated primarily with pulse methyl prednisolone for Hemophagocytic syndrome, which is one specific instance where this treatment was successful. However, it is important to note that this does not necessarily mean Methylprednisolone will always be effective for Hemophagocytic syndrome, as each case can have unique factors influencing treatment outcomes." -13619118,Methylprednisolone treats chronic obstructive pulmonary disease,1265,"In conclusion, methylprednisolone in combination with conventional medical therapy not only improved lung function values but also mean nocturnal oxyhemoglobin saturation and sleep duration in clinically stabilized COPD patients who experience nocturnal oxyhemoglobin desaturation.",True,"Is the triple 'Methylprednisolone treats chronic obstructive pulmonary disease' supported by the sentence: 'In conclusion, methylprednisolone in combination with conventional medical therapy not only improved lung function values but also mean nocturnal oxyhemoglobin saturation and sleep duration in clinically stabilized COPD patients who experience nocturnal oxyhemoglobin desaturation.'?","Yes, this sentence does indirectly support the statement that methylprednisolone can help in treating chronic obstructive pulmonary disease (COPD). The sentence mentions that methylprednisolone, when used in combination with conventional medical therapy, improved lung function values, nocturnal oxyhemoglobin saturation, and sleep duration in clinically stabilized COPD patients who experience nocturnal oxyhemoglobin desaturation. This suggests that methylprednisolone has beneficial effects for COPD patients, thus providing indirect support for its use in treating COPD." -13533673,Methylprednisolone treats macrophage activation syndrome,1266,"Following treatment with etanercept, ibuprofen, methylprednisolone, and phenylbutazone for 3 weeks, MAS deteriorated and fatal cerebral edema occurred within only 24 h.",False,"Is the triple 'Methylprednisolone treats macrophage activation syndrome' supported by the sentence: 'Following treatment with etanercept, ibuprofen, methylprednisolone, and phenylbutazone for 3 weeks, MAS deteriorated and fatal cerebral edema occurred within only 24 h.'?","No, this sentence does not support the statement that Methylprednisolone treats macrophage activation syndrome (MAS). In fact, it suggests the opposite - despite treatment with Methylprednisolone, MAS deteriorated, leading to fatal cerebral edema within 24 hours. This suggests that Methylprednisolone may not be effective in treating MAS under these circumstances, although it doesn't rule out its potential efficacy in other contexts or under different treatment conditions." -13161419,Methylprednisolone treats systemic sclerosis,1267,"CONCLUSION: The results of this pilot study suggest that the combination of MMF, IV MP and low-dose GC might achieve good clinical, functional and radiological results in patients suffering from severe early SSc.",True,"Is the triple 'Methylprednisolone treats systemic sclerosis' supported by the sentence: 'CONCLUSION: The results of this pilot study suggest that the combination of MMF, IV MP and low-dose GC might achieve good clinical, functional and radiological results in patients suffering from severe early SSc.'?","Yes, this statement does indirectly support the idea that Methylprednisolone (MP) can treat systemic sclerosis (SSc). The conclusion suggests that a combination therapy involving Mycophenolate Mofetil (MMF), Intravenous Methylprednisolone (IV MP), and low-dose glucocorticoids (GC) can have beneficial effects on patients with severe early SSc, which implies MP could be beneficial in treating SSc when used in combination therapy. However, it does not directly state that MP can treat SSc on its own, hence the indirect support." -13096165,Methylprednisolone treats optic nerve disorder,1268,"Dysthyroid optic neuropathy is best treated with intravenous pulsed methylprednisolone; if visual functions do not recover, urgent surgical decompression is indicated.",True,"Is the triple 'Methylprednisolone treats optic nerve disorder' supported by the sentence: 'Dysthyroid optic neuropathy is best treated with intravenous pulsed methylprednisolone; if visual functions do not recover, urgent surgical decompression is indicated.'?","Yes, this statement does indirectly support the claim that Methylprednisolone can be used to treat an optic nerve disorder, specifically dysthyroid optic neuropathy, as mentioned in the provided sentence. Intravenous pulsed methylprednisolone is suggested as the best initial treatment for this condition, indicating its therapeutic role in managing this particular optic nerve disorder." -12975348,Methylprednisolone treats mature T-cell and NK-cell non-Hodgkin lymphoma,1269,"Gemcitabine, cisplatin and methylprednisolone for the treatment of patients with peripheral T-cell lymphoma: the Royal Marsden Hospital experience.",False,"Is the triple 'Methylprednisolone treats mature T-cell and NK-cell non-Hodgkin lymphoma' supported by the sentence: 'Gemcitabine, cisplatin and methylprednisolone for the treatment of patients with peripheral T-cell lymphoma: the Royal Marsden Hospital experience.'?","No, this statement is not indirectly supported by the sentence provided. The sentence mentions gemcitabine, cisplatin, and methylprednisolone as being used in treatment, but it does not specify which type of lymphoma is being treated, nor does it mention whether methylprednisolone is used specifically to treat mature T-cell and NK-cell non-Hodgkin lymphoma." -12450216,Methylprednisolone treats bronchopulmonary dysplasia,1270,Hypertrophic cardiomyopathy in preterm infants treated with methylprednisolone for bronchopulmonary dysplasia.,False,Is the triple 'Methylprednisolone treats bronchopulmonary dysplasia' supported by the sentence: 'Hypertrophic cardiomyopathy in preterm infants treated with methylprednisolone for bronchopulmonary dysplasia.'?,"No, this statement does not indirectly support the claim that Methylprednisolone treats bronchopulmonary dysplasia (BPD). The sentence provided mentions Hypertrophic cardiomyopathy in preterm infants who were treated with methylprednisolone for BPD, but it does not indicate whether methylprednisolone was effective in treating BPD itself. It only suggests an observed side effect (Hypertrophic cardiomyopathy) in preterm infants who received methylprednisolone for BPD treatment, but it does not provide evidence for methylprednisolone as an effective treatment for BPD." -11895116,Methylprednisolone treats plasma cell myeloma,1271,Multiple myeloma of Stage IIa was diagnosed and she was given cytostatic therapy with 17.5 mg melphalan and 112 mg methylprednisolone daily by mouth (for 4 days at intervals of 6 weeks).,True,Is the triple 'Methylprednisolone treats plasma cell myeloma' supported by the sentence: 'Multiple myeloma of Stage IIa was diagnosed and she was given cytostatic therapy with 17.5 mg melphalan and 112 mg methylprednisolone daily by mouth (for 4 days at intervals of 6 weeks).'?,"Yes, this statement does indirectly support the claim that methylprednisolone can be used to treat plasma cell myeloma, also known as multiple myeloma, as it mentions the use of methylprednisolone in conjunction with melphalan as part of the treatment regimen for this specific stage of multiple myeloma (Stage IIa). However, it is important to note that this statement does not explicitly state that methylprednisolone is solely responsible for treating multiple myeloma, as it is part of a combination therapy involving melphalan as well, which may have an impact on its overall efficacy in treating this condition." -11882768,Methylprednisolone treats Cognitive impairment,1272,One-year cyclophosphamide treatment combined with methylprednisolone improves cognitive dysfunction in progressive forms of multiple sclerosis.,False,Is the triple 'Methylprednisolone treats Cognitive impairment' supported by the sentence: 'One-year cyclophosphamide treatment combined with methylprednisolone improves cognitive dysfunction in progressive forms of multiple sclerosis.'?,"No, this sentence does not indirectly support the claim that Methylprednisolone treats cognitive impairment in general, but it does suggest that it may improve cognitive dysfunction in specific cases, namely in progressive forms of multiple sclerosis when used in combination with cyclophosphamide treatment. The sentence does not provide enough evidence to make a general claim about Methylprednisolone treating cognitive impairment in all cases." -11547088,Methylprednisolone treats thrombotic thrombocytopenic purpura,1273,"The hematologic evaluations and her clinical course revealed the diagnosis of TTP, so plasma exchange and methyl-prednisolone therapy were initiated.",True,"Is the triple 'Methylprednisolone treats thrombotic thrombocytopenic purpura' supported by the sentence: 'The hematologic evaluations and her clinical course revealed the diagnosis of TTP, so plasma exchange and methyl-prednisolone therapy were initiated.'?","Yes, this sentence indirectly supports the statement that Methylprednisolone treats Thrombotic Thrombocytopenic Purpura (TTP). The sentence mentions that plasma exchange and methyl-prednisolone therapy were initiated after the diagnosis of TTP, which implies that methyl-prednisolone is used as a treatment for TTP. However, it doesn't explicitly state that Methylprednisolone alone treats TTP, hence the term 'indirectly'." -11313619,Methylprednisolone treats vestibular neuronitis,1274,"METHODS: We performed a prospective, randomized, double-blind, two-by-two factorial trial in which patients with acute vestibular neuritis were randomly assigned to treatment with placebo, methylprednisolone, valacyclovir, or methylprednisolone plus valacyclovir.",True,"Is the triple 'Methylprednisolone treats vestibular neuronitis' supported by the sentence: 'METHODS: We performed a prospective, randomized, double-blind, two-by-two factorial trial in which patients with acute vestibular neuritis were randomly assigned to treatment with placebo, methylprednisolone, valacyclovir, or methylprednisolone plus valacyclovir.'?","Yes, the statement is indirectly supported by the sentence provided. The sentence mentions a study where patients with acute vestibular neuritis were treated with methylprednisolone, which suggests that methylprednisolone is used as a treatment for this condition. However, it does not explicitly state that methylprednisolone is used to treat vestibular neuronitis, which is a specific type of vestibular neuritis. Therefore, while there is some indirect support, it is not directly stated in the sentence provided." -10801960,Methylprednisolone treats B-cell chronic lymphocytic leukemia,1275,High dose methylprednisolone can induce remissions in CLL patients with p53 abnormalities.,False,Is the triple 'Methylprednisolone treats B-cell chronic lymphocytic leukemia' supported by the sentence: 'High dose methylprednisolone can induce remissions in CLL patients with p53 abnormalities.'?,"No, this statement does not indirectly support the claim that Methylprednisolone treats B-cell chronic lymphocytic leukemia (CLL). The statement suggests that high dose methylprednisolone can induce remissions in CLL patients with p53 abnormalities, but it does not imply that methylprednisolone is a treatment for CLL. It only suggests that it may be effective in certain subsets of patients, specifically those with p53 abnormalities. Furthermore, even if it does induce remissions, it does not necessarily mean it is treating the disease, as remission can also be achieved through palliative care or other means." -10634179,Methylprednisolone treats Crohn disease,1276,An example of acute pancreatitis developing five weeks after initial treatment with 5-aminosalicylic acid (5-ASA) and methylprednisolone for severe Crohn's disease is reported in a 37 year old female patient.,False,Is the triple 'Methylprednisolone treats Crohn disease' supported by the sentence: 'An example of acute pancreatitis developing five weeks after initial treatment with 5-aminosalicylic acid (5-ASA) and methylprednisolone for severe Crohn's disease is reported in a 37 year old female patient.'?,"No, this sentence does not indirectly support the statement that Methylprednisolone treats Crohn disease. The sentence only mentions that Methylprednisolone was used in treatment for severe Crohn’s disease, but it does not state that it was effective in treating the disease itself, nor does it imply it has any causative role in treating Crohn disease." -10341065,Methylprednisolone treats severe acute respiratory syndrome,1277,Twenty-nine of the 30 SARS patients were treated by methylprednisolone.,True,Is the triple 'Methylprednisolone treats severe acute respiratory syndrome' supported by the sentence: 'Twenty-nine of the 30 SARS patients were treated by methylprednisolone.'?,"Yes, this statement does provide indirect evidence to support the claim that methylprednisolone may be used to treat severe acute respiratory syndrome (SARS). The sentence states that 29 out of 30 SARS patients were treated using methylprednisolone, suggesting its use as a potential treatment for SARS. However, it does not directly state that methylprednisolone is effective in treating SARS, only that it was used in treatment attempts for SARS patients." -10289517,Methylprednisolone treats graft versus host disease,1278,"CASE SUMMARY: A 2-year-old white boy with a history of relapsed acute lymphoblastic leukemia underwent a bone marrow transplant and developed graft-versus-host disease, which was treated with methylprednisolone.",True,"Is the triple 'Methylprednisolone treats graft versus host disease' supported by the sentence: 'CASE SUMMARY: A 2-year-old white boy with a history of relapsed acute lymphoblastic leukemia underwent a bone marrow transplant and developed graft-versus-host disease, which was treated with methylprednisolone.'?","Yes, the sentence does indirectly support the statement that Methylprednisolone treats graft versus host disease. The case summary mentions that a patient developed graft-versus-host disease after a bone marrow transplant, and this condition was treated with Methylprednisolone. This implies that Methylprednisolone was used as a treatment for graft-versus-host disease, which aligns with the original statement." -10221573,Methylprednisolone treats myeloproliferative neoplasm,1279,The effects of HDMP should be explored in patients with other subtypes of AML who present with MT.,False,Is the triple 'Methylprednisolone treats myeloproliferative neoplasm' supported by the sentence: 'The effects of HDMP should be explored in patients with other subtypes of AML who present with MT.'?,"No, this statement does not indirectly support that Methylprednisolone (HDMP) treats myeloproliferative neoplasm (MPN). The sentence only mentions its potential effects in other subtypes of acute myeloid leukemia (AML) which is different from MPN." -10136260,Methylprednisolone treats acute lymphoblastic leukemia,1280,"We examined the effect of high-dose methylprednisolone (HDMP) on blast reduction rate and compared it to conventional dose steroid treatment, administered during the first 7+ days of the induction remission period in patients with acute lymphoblastic leukemia (ALL).",True,"Is the triple 'Methylprednisolone treats acute lymphoblastic leukemia' supported by the sentence: 'We examined the effect of high-dose methylprednisolone (HDMP) on blast reduction rate and compared it to conventional dose steroid treatment, administered during the first 7+ days of the induction remission period in patients with acute lymphoblastic leukemia (ALL).'?","Yes, this sentence does provide indirect support for the statement that methylprednisolone treats acute lymphoblastic leukemia (ALL). The sentence mentions a study where high-dose methylprednisolone (HDMP) was administered to patients with ALL during the induction remission period, which suggests that methylprednisolone is used as a treatment for ALL. However, it does not directly state that methylprednisolone is used to treat acute leukemia, hence it is indirect support." -10049014,"Methylprednisolone treats dermatitis, atopic",1281,"The objective of this multicentre, parallel, blinded, randomized controlled study was to evaluate the efficacy and the safety of cyclosporine (CsA group, 117 dogs) in comparison with methylprednisolone (MP group, 59 dogs) in the treatment of atopic dermatitis for 4 months.",True,"Is the triple 'Methylprednisolone treats dermatitis, atopic' supported by the sentence: 'The objective of this multicentre, parallel, blinded, randomized controlled study was to evaluate the efficacy and the safety of cyclosporine (CsA group, 117 dogs) in comparison with methylprednisolone (MP group, 59 dogs) in the treatment of atopic dermatitis for 4 months.'?","Yes, this sentence does indirectly support the statement that Methylprednisolone (MP) is used to treat atopic dermatitis, as it mentions MP being used in the treatment group in a study on atopic dermatitis in dogs, implying its application in this context." -9980473,Methylprednisolone treats immunoglobulin a vasculitis,1282,"CASE DESCRIPTION: A 33-year-old woman previously treated with methylprednisolone and cyclophosphamide for Henoch-Schonlein purpura was transferred from a referring hospital because of sore throat, fever, and chills.",False,"Is the triple 'Methylprednisolone treats immunoglobulin a vasculitis' supported by the sentence: 'CASE DESCRIPTION: A 33-year-old woman previously treated with methylprednisolone and cyclophosphamide for Henoch-Schonlein purpura was transferred from a referring hospital because of sore throat, fever, and chills.'?","No, this sentence does not indirectly support the statement that Methylprednisolone treats Immunoglobulin A vasculitis (which is another name for Henoch-Schonlein purpura). The sentence only mentions that the patient was previously treated with methylprednisolone for Henoch-Schonlein purpura, but it does not indicate that this treatment was effective for her condition." -9720542,Methylprednisolone treats lupus nephritis,1283,The last significant breakthrough in the treatment of systemic lupus erythematosus (SLE) was the use of cyclophosphamide and methylprednisolone in the treatment of lupus nephritis.,True,Is the triple 'Methylprednisolone treats lupus nephritis' supported by the sentence: 'The last significant breakthrough in the treatment of systemic lupus erythematosus (SLE) was the use of cyclophosphamide and methylprednisolone in the treatment of lupus nephritis.'?,"Yes, this statement does indirectly support the idea that methylprednisolone is used in treating lupus nephritis, which is a complication of systemic lupus erythematosus (SLE). The sentence mentions methylprednisolone in conjunction with cyclophosphamide as part of a treatment regimen for lupus nephritis, indicating its use in managing this condition. However, it does not explicitly state that methylprednisolone alone is effective in treating lupus nephritis, so any claims about its efficacy should be based on further evidence from clinical trials or other scientific studies." -8761529,Methylprednisolone treats asthma,1284,Methylprednisolone suleptanate (Promedrol) is a prodrug of methylprednisolone being developed by Pharmacia Corp (formerly Pharmacia & Upjohn) for the treatment of asthma.,False,Is the triple 'Methylprednisolone treats asthma' supported by the sentence: 'Methylprednisolone suleptanate (Promedrol) is a prodrug of methylprednisolone being developed by Pharmacia Corp (formerly Pharmacia & Upjohn) for the treatment of asthma.'?,"No, this statement does not indirectly support that Methylprednisolone treats asthma. The sentence mentions Methylprednisolone suleptanate, which is a prodrug of Methylprednisolone, but it does not confirm Methylprednisolone itself is used for treating asthma, only its development for such treatment is mentioned." -8588816,Methylprednisolone treats Bell's palsy,1285,"On these basis, we have studied the efficacity of parenteral association of 30 mg/Kg/j of Aciclovir and 1 mg/Kg/j of Methylprednisolone in the treatment of Bell's palsy with less than 12 days of evolution.",True,"Is the triple 'Methylprednisolone treats Bell's palsy' supported by the sentence: 'On these basis, we have studied the efficacity of parenteral association of 30 mg/Kg/j of Aciclovir and 1 mg/Kg/j of Methylprednisolone in the treatment of Bell's palsy with less than 12 days of evolution.'?","Yes, there is indirect support for the statement that Methylprednisolone can be used to treat Bell’s palsy based on the provided sentence. The sentence mentions a study where Methylprednisolone was used in combination with Aciclovir to treat Bell’s palsy cases with less than 12 days of evolution, indicating its potential use in treating this condition. However, it does not directly state that Methylprednisolone alone can treat Bell’s palsy, so further research would be needed to confirm this." -8568939,Methylprednisolone treats myasthenia gravis,1286,"Treatment with methylprednisolone for myasthenia gravis was associated with a marked decrease in both biochemical markers of bone formation and resorption without any changes in endogenous cAMP and serum levels of calcium, PTH, and 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3].",False,"Is the triple 'Methylprednisolone treats myasthenia gravis' supported by the sentence: 'Treatment with methylprednisolone for myasthenia gravis was associated with a marked decrease in both biochemical markers of bone formation and resorption without any changes in endogenous cAMP and serum levels of calcium, PTH, and 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3].'?","No, this sentence does not indirectly support the statement that Methylprednisolone treats myasthenia gravis. The sentence discusses the effects of Methylprednisolone treatment on various biochemical markers in patients with myasthenia gravis, but it does not provide any information about the efficacy of Methylprednisolone in treating this condition." -8562694,Methylprednisolone treats endocrine exophthalmos,1287,PATIENTS AND METHODS: Fourteen euthyroid patients with severe Graves' ophthalmopathy were treated with high-dose intravenous methylprednisolone during 6 months and followed-up for 24-48 months by clinical and ophthalmological assessment.,True,Is the triple 'Methylprednisolone treats endocrine exophthalmos' supported by the sentence: 'PATIENTS AND METHODS: Fourteen euthyroid patients with severe Graves' ophthalmopathy were treated with high-dose intravenous methylprednisolone during 6 months and followed-up for 24-48 months by clinical and ophthalmological assessment.'?,"Yes, the triple ""Methylprednisolone treats endocrine exophthalmos"" is at least indirectly supported by the sentence provided. The sentence mentions treating patients with severe Graves' ophthalmopathy, which is an eye condition associated with endocrine exophthalmos, using high-dose intravenous methylprednisolone for 6 months, which suggests its potential therapeutic role in managing this condition. However, it is important to note that this is an indirect inference, as the sentence does not explicitly state that methylprednisolone is used specifically to treat endocrine exophthalmos, but rather Graves' ophthalmopathy, which can include exophthalmos as one of its symptoms." -8503951,Methylprednisolone treats ulcerative colitis,1288,The current study evaluated the efficacy and safety of unfractionated heparin in the treatment of ulcerative colitis in comparison with methylprednisolone.,True,Is the triple 'Methylprednisolone treats ulcerative colitis' supported by the sentence: 'The current study evaluated the efficacy and safety of unfractionated heparin in the treatment of ulcerative colitis in comparison with methylprednisolone.'?,"Yes, this statement does indirectly support the claim that Methylprednisolone can be used to treat ulcerative colitis. The study mentioned here is comparing the efficacy and safety of unfractionated heparin with methylprednisolone in treating ulcerative colitis, which implies that methylprednisolone is already being used, or at least considered, for treating this condition. However, it doesn't directly prove that methylprednisolone is effective in treating ulcerative colitis, it only suggests its use in this context." -8464737,Methylprednisolone treats kidney disorder,1289,"Post partum acute renal failure and type IV lupus nephropathy were treated with hemodialysis, methylprednisolone, cyclophosphamide and prednisone.",True,"Is the triple 'Methylprednisolone treats kidney disorder' supported by the sentence: 'Post partum acute renal failure and type IV lupus nephropathy were treated with hemodialysis, methylprednisolone, cyclophosphamide and prednisone.'?","Yes, this statement does indirectly support the idea that Methylprednisolone can be used to treat a kidney disorder, specifically type IV lupus nephropathy in this case, as it is mentioned as one of the treatments used for post partum acute renal failure and type IV lupus nephropathy in this sentence." -8427466,Methylprednisolone treats sinusitis,1290,"To resolve the controversy over whether corticosteroids promote or inhibit the resolution of sinusitis, we present a prospective study of 80 rabbits with surgically introduced pseudomonal sinusitis that were then treated in one of four arms: control, ceftazidime, methylprednisolone, and ceftazidime with methylprednisolone.",True,"Is the triple 'Methylprednisolone treats sinusitis' supported by the sentence: 'To resolve the controversy over whether corticosteroids promote or inhibit the resolution of sinusitis, we present a prospective study of 80 rabbits with surgically introduced pseudomonal sinusitis that were then treated in one of four arms: control, ceftazidime, methylprednisolone, and ceftazidime with methylprednisolone.'?","Yes, this statement does indirectly support the claim that Methylprednisolone can treat sinusitis, as it mentions Methylprednisolone being used in a study to treat pseudomonal sinusitis in rabbits, implying its potential use in treating sinusitis. However, it does not directly state that Methylprednisolone treats sinusitis, as it is an observational study in rabbits, not humans, and further research would be needed to confirm its effectiveness in humans." -8330903,Methylprednisolone treats systemic lupus erythematosus,1291,MAIN RESULTS: We found no randomised controlled trials comparing cyclophosphamide versus methylprednisolone for the treatment of neuropsychiatric involvement in the systemic lupus erythematosus.,False,Is the triple 'Methylprednisolone treats systemic lupus erythematosus' supported by the sentence: 'MAIN RESULTS: We found no randomised controlled trials comparing cyclophosphamide versus methylprednisolone for the treatment of neuropsychiatric involvement in the systemic lupus erythematosus.'?,"No, this statement does not indirectly support the claim that Methylprednisolone treats systemic lupus erythematosus (SLE). The sentence only states that there is no evidence found in randomized controlled trials comparing cyclophosphamide versus methylprednisolone for treating neuropsychiatric involvement in SLE. It does not provide any information about methylprednisolone treating SLE directly or indirectly." -8291810,Methylprednisolone treats pneumonia,1292,High-dose methylprednisolone was administered for treatment of the pneumonitis.,True,Is the triple 'Methylprednisolone treats pneumonia' supported by the sentence: 'High-dose methylprednisolone was administered for treatment of the pneumonitis.'?,"Yes, this statement could indirectly support the idea that Methylprednisolone can be used to treat pneumonia, specifically in this case, it was used to treat pneumonitis, which is a type of inflammation of the lung that can be caused by infection, including pneumonia. However, it is important to note that this does not directly state that Methylprednisolone is used to treat pneumonia, but rather implies its use in treating lung inflammation, which can be caused by pneumonia among other things." -8227578,Methylprednisolone treats mucocutaneous lymph node syndrome,1293,"Additional antiinflammatory therapy, such as IV methylprednisolone and IV cyclophosphamide, may be helpful in treating persistent KD.",True,"Is the triple 'Methylprednisolone treats mucocutaneous lymph node syndrome' supported by the sentence: 'Additional antiinflammatory therapy, such as IV methylprednisolone and IV cyclophosphamide, may be helpful in treating persistent KD.'?","Yes, the statement is indirectly supported as it mentions IV methylprednisolone as an additional therapy for persistent Kawasaki Disease (KD), which is also known as Mucocutaneous Lymph Node Syndrome. However, it does not explicitly state that methylprednisolone is used to treat MCLS, but rather as an additional treatment for persistent KD, which suggests it could be used for MCLS as well, given they are the same disease." -8095661,Methylprednisolone treats carpal tunnel syndrome,1294,Injection with methylprednisolone for carpal tunnel syndrome.,True,Is the triple 'Methylprednisolone treats carpal tunnel syndrome' supported by the sentence: 'Injection with methylprednisolone for carpal tunnel syndrome.'?,"Yes, this is indirectly supported because both sentences refer to Methylprednisolone being used in relation to Carpal Tunnel Syndrome, implying a treatment context. The first sentence suggests Methylprednisolone as a treatment for Carpal Tunnel Syndrome, while the second sentence provides evidence of this treatment being administered via injection." -8083160,Methylprednisolone treats thrombocytopenia,1295,"After a course of high-dose methylprednisolone therapy with a diagnosis of Evans syndrome, complete response for thrombocytopenia and partial response for anemia was achieved.",True,"Is the triple 'Methylprednisolone treats thrombocytopenia' supported by the sentence: 'After a course of high-dose methylprednisolone therapy with a diagnosis of Evans syndrome, complete response for thrombocytopenia and partial response for anemia was achieved.'?","Yes, this sentence indirectly supports the statement that methylprednisolone can treat thrombocytopenia, which is a condition characterized by low platelet count in the blood, as part of Evans syndrome treatment. The sentence states that after a course of high-dose methylprednisolone therapy, there was a complete response for thrombocytopenia, indicating an improvement in platelet count, which is one of the primary symptoms of thrombocytopenia. However, it is important to note that this statement does not directly imply methylprednisolone as the sole treatment for thrombocytopenia, as it is part of a broader therapy for Evans syndrome, which is an autoimmune disorder affecting both platelets (thrombocytopenia) and red blood cells (anemia)." -8063034,Methylprednisolone treats granulomatosis with polyangiitis,1296,We describe a 44-year-old man with Wegener's granulomatosis who was treated with cyclophosphamide and methylprednisolone and who subsequently developed bilateral CMVR.,False,Is the triple 'Methylprednisolone treats granulomatosis with polyangiitis' supported by the sentence: 'We describe a 44-year-old man with Wegener's granulomatosis who was treated with cyclophosphamide and methylprednisolone and who subsequently developed bilateral CMVR.'?,"No, this sentence does not indirectly support the statement that Methylprednisolone treats granulomatosis with polyangiitis (GPA, formerly known as Wegener’s granulomatosis). In fact, it suggests the opposite. The patient was already diagnosed with GPA, was being treated for it (with cyclophosphamide and methylprednisolone), but then developed bilateral cytomegalovirus retinitis (CMVR). The development of CMVR despite treatment suggests that the treatment (which included methylprednisolone) was not effective at controlling GPA in this patient, at least not completely, as GPA can predispose patients to opportunistic infections like CMVR due to their immunocompromised state caused by treatments like methylprednisolone." -8018847,Methylprednisolone treats Pain,1297,A comparative trial of botulinum toxin type A and methylprednisolone for the treatment of myofascial pain syndrome and pain from chronic muscle spasm.,True,Is the triple 'Methylprednisolone treats Pain' supported by the sentence: 'A comparative trial of botulinum toxin type A and methylprednisolone for the treatment of myofascial pain syndrome and pain from chronic muscle spasm.'?,"Yes, this statement does indirectly support the idea that Methylprednisolone can be used to treat pain, specifically in relation to myofascial pain syndrome and chronic muscle spasm, as per the mentioned comparative trial study involving its use against Botulinum toxin type A. However, it does not explicitly address whether Methylprednisolone is effective in treating pain in all scenarios, nor does it mention treating pain in general, as it is specific to certain conditions related to muscle spasms." -7905007,Methylprednisolone treats chronic progressive multiple sclerosis,1298,OBJECTIVE: To determine if there are variables linked to responsiveness to pulse cyclophosphamide/methylprednisolone therapy in progressive Multiple Sclerosis (MS).,False,Is the triple 'Methylprednisolone treats chronic progressive multiple sclerosis' supported by the sentence: 'OBJECTIVE: To determine if there are variables linked to responsiveness to pulse cyclophosphamide/methylprednisolone therapy in progressive Multiple Sclerosis (MS).'?,"No, this statement does not indirectly support the claim that Methylprednisolone treats chronic progressive multiple sclerosis. The sentence provided is about determining variables linked to responsiveness to pulse cyclophosphamide/methylprednisolone therapy in progressive Multiple Sclerosis (MS). It does not mention or imply that Methylprednisolone is a treatment for chronic progressive multiple sclerosis, but rather it is part of a therapy regime being studied for its effectiveness in treating MS in general, not specifically the chronic progressive form." -7853881,Methylprednisolone treats rheumatoid arthritis,1299,Oral low-dose glucocorticosteroids as compared with intravenous methylprednisolone pulses in the treatment of rheumatoid arthritis.,False,Is the triple 'Methylprednisolone treats rheumatoid arthritis' supported by the sentence: 'Oral low-dose glucocorticosteroids as compared with intravenous methylprednisolone pulses in the treatment of rheumatoid arthritis.'?,"No, this statement does not support the claim that Methylprednisolone treats rheumatoid arthritis. In fact, it suggests the opposite - oral low-dose glucocorticosteroids (which could include Methylprednisolone) are compared to intravenous methylprednisolone pulses, implying both forms are used in treatment, but not necessarily that Methylprednisolone is specifically effective against rheumatoid arthritis." -7827490,Methylprednisolone treats optic neuritis,1300,CONCLUSIONS: The ONTT has led to a dramatic reduction in the use of oral prednisone without a preceding course of intravenous methylprednisolone in the treatment of acute optic neuritis.,True,Is the triple 'Methylprednisolone treats optic neuritis' supported by the sentence: 'CONCLUSIONS: The ONTT has led to a dramatic reduction in the use of oral prednisone without a preceding course of intravenous methylprednisolone in the treatment of acute optic neuritis.'?,"Yes, this statement does provide indirect support for the claim that Methylprednisolone is used to treat optic neuritis, as it mentions intravenous methylprednisolone as part of the treatment regimen for acute optic neuritis in the ONTT (Optic Neuritis Treatment Trial). However, it does not explicitly state that Methylprednisolone is used to treat optic neuritis, but rather implies it through its reference in the treatment protocol for acute optic neuritis in the ONTT study, which led to reduced use of oral prednisone when not preceded by intravenous methylprednisolone in such treatments." -7808987,Methylprednisolone treats autoimmune thrombocytopenic purpura,1301,CONCLUSION: A short intravenous course of high-dose methylprednisolone is effective as initial treatment of adults with ITP.,True,Is the triple 'Methylprednisolone treats autoimmune thrombocytopenic purpura' supported by the sentence: 'CONCLUSION: A short intravenous course of high-dose methylprednisolone is effective as initial treatment of adults with ITP.'?,"Yes, this is indirectly supported. The sentence states that high-dose methylprednisolone is effective as initial treatment for adults with ITP (Idiopathic Thrombocytopenic Purpura), which is an autoimmune disease where the body attacks its own platelets leading to low platelet counts, also known as thrombocytopenia. Therefore, methylprednisolone, being effective in treating ITP, can indirectly be said to treat autoimmune thrombocytopenic purpura, as it is essentially treating one form (ITP) of this condition. However, it is important to note that this is an indirect inference, as ITP is not explicitly stated as being equivalent to autoimmune thrombocytopenic purpura in this conclusion, although they share similar characteristics as mentioned above." -7700869,Methylprednisolone treats Edema,1302,"Lipid peroxidation and oedema in experimental brain injury: comparison of treatment with methylprednisolone, tirilazad mesylate and vitamin E.",False,"Is the triple 'Methylprednisolone treats Edema' supported by the sentence: 'Lipid peroxidation and oedema in experimental brain injury: comparison of treatment with methylprednisolone, tirilazad mesylate and vitamin E.'?","No, this statement is not indirectly supported by the given sentence. The sentence discusses an experimental brain injury study where methylprednisolone, tirilazad mesylate, and vitamin E were compared in terms of their effects on lipid peroxidation and oedema (edema). However, it does not mention methylprednisolone as a treatment for edema, but rather as one of the substances being investigated for its influence on edema development in brain injury cases." -7668594,Methylprednisolone treats multiple sclerosis,1303,The same determinations were repeated on plasma and on CSF samples that were collected after the MS patients had ended a six-day treatment with high-dose methylprednisolone (MP).,True,Is the triple 'Methylprednisolone treats multiple sclerosis' supported by the sentence: 'The same determinations were repeated on plasma and on CSF samples that were collected after the MS patients had ended a six-day treatment with high-dose methylprednisolone (MP).'?,"Yes, this sentence does indirectly support the statement that Methylprednisolone (MP) is used to treat Multiple Sclerosis (MS). The sentence mentions that MS patients were given high-dose MP for six days, which implies that MP is being used as a treatment for MS. However, it does not directly state that MP treats MS, hence the indirect support." -7649490,Methylprednisolone treats aplastic anemia,1304,"Neutropenic infections are the major cause of morbidity and mortality in the treatment of aplastic anemia (AA) with antilymphocyte globulin (ALG), cyclosporin A (CSA), and methylprednisolone (MP).",True,"Is the triple 'Methylprednisolone treats aplastic anemia' supported by the sentence: 'Neutropenic infections are the major cause of morbidity and mortality in the treatment of aplastic anemia (AA) with antilymphocyte globulin (ALG), cyclosporin A (CSA), and methylprednisolone (MP).'?","Yes, the statement does provide indirect support for the idea that Methylprednisolone (MP) can be used to treat aplastic anemia (AA) in conjunction with other treatments like antilymphocyte globulin (ALG) and cyclosporin A (CSA). The sentence mentions MP as part of the treatment regimen for AA, implying its use in managing this condition, although it does not explicitly state that MP is used to treat AA directly. The specific context mentioned in the sentence, neutropenic infections, is one potential complication during treatment, rather than being related to MP treating AA directly. Nonetheless, it shows MP is used as part of AA treatment, providing indirect support for its use in this context." -7552935,Methylprednisolone treats Inflammation,1305,Methylprednisolone treatment resulted in the greatest reduction in the inflammatory cell infiltrate but the numbers of infected neurons did not increase concomitantly.,True,Is the triple 'Methylprednisolone treats Inflammation' supported by the sentence: 'Methylprednisolone treatment resulted in the greatest reduction in the inflammatory cell infiltrate but the numbers of infected neurons did not increase concomitantly.'?,"Yes, this statement does indirectly support the claim that Methylprednisolone treats inflammation, as it mentions that Methylprednisolone treatment resulted in a reduction in inflammatory cell infiltrate, which is an indicator of reduced inflammation. However, it does not directly mention Methylprednisolone as a treatment for inflammation, but it does support its anti-inflammatory properties, which is one way it can treat inflammation." -7483648,Methylprednisolone treats adult acute respiratory distress syndrome,1306,Severe systemic inflammatory response syndrome with shock and ARDS resulting from Still's disease: clinical response with high-dose pulse methylprednisolone therapy.,True,Is the triple 'Methylprednisolone treats adult acute respiratory distress syndrome' supported by the sentence: 'Severe systemic inflammatory response syndrome with shock and ARDS resulting from Still's disease: clinical response with high-dose pulse methylprednisolone therapy.'?,"Yes, this statement does provide indirect evidence supporting the use of Methylprednisolone to treat adult Acute Respiratory Distress Syndrome (ARDS). The sentence mentions successful treatment of ARDS in an adult patient who had it as a complication of Still's disease using high-dose pulse methylprednisolone therapy. Therefore, it suggests methylprednisolone as an effective treatment for ARDS, although it was used in conjunction with treating Still's disease, which is an autoimmune disorder characterized by systemic inflammation, fever, rash, and joint pain, among other symptoms. However, it is important to note that direct clinical trials may be required to establish more conclusive evidence for this treatment in ARDS patients without Still's disease, as various factors could influence treatment response, including underlying conditions, disease severity, dosage, treatment duration, and patient-specific genetic factors, among others." -7432980,Methylprednisolone treats myelodysplastic syndrome,1307,Eosinophilic fasciitis associated with autoimmune thyroid disease and myelodysplasia treated with pulsed methylprednisolone and antihistamines.,True,Is the triple 'Methylprednisolone treats myelodysplastic syndrome' supported by the sentence: 'Eosinophilic fasciitis associated with autoimmune thyroid disease and myelodysplasia treated with pulsed methylprednisolone and antihistamines.'?,"Yes, this statement indirectly supports the idea that Methylprednisolone can be used to treat myelodysplastic syndrome (MDS). The sentence mentions that eosinophilic fasciitis associated with autoimmune thyroid disease and myelodysplasia was treated with pulsed methylprednisolone and antihistamines, implying that methylprednisolone was used to treat the MDS component in this case, even though it was not specifically mentioned as the sole treatment for MDS. However, it is important to note that this is only one case report, so further research is needed to establish this as a definitive treatment for MDS." -16097513,Cefotaxime treats osteomyelitis,1308,Cefotaxime in the treatment of chronic osteomyelitis caused by gram-negative bacilli.,True,Is the triple 'Cefotaxime treats osteomyelitis' supported by the sentence: 'Cefotaxime in the treatment of chronic osteomyelitis caused by gram-negative bacilli.'?,"Yes, this statement is indirectly supported by the provided sentence. The sentence states that Cefotaxime can be used in the treatment of chronic osteomyelitis caused by gram-negative bacilli. This implies that Cefotaxime can be effective against certain types of bacterial infections in bone tissue, which is what osteomyelitis is. Therefore, it can be inferred that Cefotaxime could potentially be used to treat osteomyelitis, even though the original sentence does not explicitly state this." -15119078,Cefotaxime treats peritonitis,1309,Aztreonam and cefotaxime were compared in 44 cirrhotic patients who had 52 episodes of gram-negative spontaneous peritonitis.,True,Is the triple 'Cefotaxime treats peritonitis' supported by the sentence: 'Aztreonam and cefotaxime were compared in 44 cirrhotic patients who had 52 episodes of gram-negative spontaneous peritonitis.'?,"Yes, this statement does indirectly support the claim that Cefotaxime can be used to treat Peritonitis in some cases, as it mentions Cefotaxime being used in patients who had episodes of spontaneous Peritonitis, which is a type of Peritonitis. However, it does not specifically state that Cefotaxime was used to treat Peritonitis in these cases, nor does it compare its effectiveness to other treatments for Peritonitis, such as Aztreonam alone." -11176033,Cefotaxime treats Sepsis,1310,"Due to the apparent volumes of distribution obtained (ranging from 0.48 to 0.51 L/kg), considering the overall clinical efficacy obtained (90% for the 10 mg/kg dose and 75% for the 20 mg/kg dose), and due to the rapid improvement observed after a few doses of the drug (1.8 to 2.5 doses to 'clinical improvement'), it is safe to postulate such doses of cefotaxime as excellent choices for the treatment of septicaemia in dogs.",True,"Is the triple 'Cefotaxime treats Sepsis' supported by the sentence: 'Due to the apparent volumes of distribution obtained (ranging from 0.48 to 0.51 L/kg), considering the overall clinical efficacy obtained (90% for the 10 mg/kg dose and 75% for the 20 mg/kg dose), and due to the rapid improvement observed after a few doses of the drug (1.8 to 2.5 doses to 'clinical improvement'), it is safe to postulate such doses of cefotaxime as excellent choices for the treatment of septicaemia in dogs.'?","Yes, the statement is indirectly supported by the provided sentence. The sentence mentions cefotaxime as an effective treatment for septicaemia in dogs, which is a form of sepsis, and it describes the doses used as excellent choices based on their distribution volume, clinical efficacy, and rapid improvement rate. However, it does not explicitly mention Cefotaxime treating sepsis, but it implies it." -8153267,Cefotaxime treats bacterial infectious disease,1311,These results suggest that amoxicillin-clavulanic acid is an effective alternative to cefotaxime for the empirical treatment of bacterial infections in cirrhosis.,False,Is the triple 'Cefotaxime treats bacterial infectious disease' supported by the sentence: 'These results suggest that amoxicillin-clavulanic acid is an effective alternative to cefotaxime for the empirical treatment of bacterial infections in cirrhosis.'?,"No, this statement does not indirectly support the claim that cefotaxime is used to treat bacterial infections, but rather it suggests an alternative to cefotaxime, which is amoxicillin-clavulanic acid, for treating such infections in cirrhosis patients. The claim would be indirectly supported if it suggested cefotaxime as an effective treatment, but it does not mention cefotaxime in this context at all, let alone as an effective treatment for bacterial infections in general, not only in cirrhosis patients." -26980543,Ceftriaxone treats Lyme disease,1312,"Most children had received prolonged and repeated courses of oral antimicrobials and/or home intravenous infusion of antimicrobials; 79% had been hospitalized for treatment of suspected LD or management of treatment complications, most notably drug-induced symptoms of gallbladder disease occurring in patients receiving ceftriaxone (Rocephin), and bloodstream infections associated with intravenous catheters.",True,"Is the triple 'Ceftriaxone treats Lyme disease' supported by the sentence: 'Most children had received prolonged and repeated courses of oral antimicrobials and/or home intravenous infusion of antimicrobials; 79% had been hospitalized for treatment of suspected LD or management of treatment complications, most notably drug-induced symptoms of gallbladder disease occurring in patients receiving ceftriaxone (Rocephin), and bloodstream infections associated with intravenous catheters.'?","Yes, this sentence does provide indirect support for the statement that Ceftriaxone (Rocephin) is used to treat Lyme disease (LD). The sentence mentions that 79% of children had received treatment for suspected LD, and among those treated, many had experienced drug-induced symptoms of gallbladder disease from Ceftriaxone (Rocephin). This implies that Ceftriaxone was used as part of their treatment regimen for suspected LD, suggesting its use for treating Lyme disease, albeit indirectly through inference." -26401802,Ceftriaxone treats Sepsis,1313,"Clinical study of Rocephin, a 3d generation cephalosporin, in various septicaemias.",True,"Is the triple 'Ceftriaxone treats Sepsis' supported by the sentence: 'Clinical study of Rocephin, a 3d generation cephalosporin, in various septicaemias.'?","Yes, this statement does provide indirect support for the claim that Ceftriaxone, which is also a 3rd generation cephalosporin like Rocephin, can be used to treat sepsis. Rocephin, as mentioned in the study, has been clinically tested for various septicaemias, which is another term for sepsis. This implies that antibiotics within the same class as Rocephin, like Ceftriaxone, could also be effective in treating sepsis due to their similar mechanisms of action. However, it is important to note that this does not directly prove Ceftriaxone's efficacy in treating sepsis, as it would require clinical studies specifically involving Ceftriaxone to confirm its effectiveness in treating sepsis patients." -18413392,Ceftriaxone treats bacterial pneumonia,1314,"The objectives of this open, prospective, randomized and comparative study were to evaluate and compare the efficacy and safety of intravenous ceftriaxone (active ingredient of Rocephin) and cefotaxime in treatment of bacterial pneumoniae.",True,"Is the triple 'Ceftriaxone treats bacterial pneumonia' supported by the sentence: 'The objectives of this open, prospective, randomized and comparative study were to evaluate and compare the efficacy and safety of intravenous ceftriaxone (active ingredient of Rocephin) and cefotaxime in treatment of bacterial pneumoniae.'?","Yes, the statement ""Ceftriaxone treats bacterial pneumonia"" is at least indirectly supported by the sentence provided. This is because Ceftriaxone is mentioned as an active ingredient in Rocephin, which is being studied for its efficacy and safety in treating bacterial pneumonia in comparison to cefotaxime. However, it is important to note that this does not directly confirm that Ceftriaxone alone treats bacterial pneumonia, as it is being compared to another treatment in this study." -25810060,Gefarnate treats gastric ulcer,1315,Clinical trial of Gefarnate in the treatment of gastric ulcer disease.,True,Is the triple 'Gefarnate treats gastric ulcer' supported by the sentence: 'Clinical trial of Gefarnate in the treatment of gastric ulcer disease.'?,"Yes, this statement is at least indirectly supported by the sentence provided, as it mentions a clinical trial involving Gefarnate specifically designed to treat gastric ulcers, which implies Gefarnate has some therapeutic effect on this condition." -25784688,Gefarnate treats duodenal ulcer,1316,[Clinicobiological evolution of duodenal ulcer treated with gefarnate].,True,Is the triple 'Gefarnate treats duodenal ulcer' supported by the sentence: '[Clinicobiological evolution of duodenal ulcer treated with gefarnate].'?,"Yes, it is indirectly supported. The title ""Clinicobiological evolution of duodenal ulcer treated with gefarnate"" suggests that this study is investigating the effects of gefarnate on duodenal ulcers, implying that gefarnate is used to treat this condition. However, it doesn't provide direct evidence of gefarnate treating duodenal ulcers as it might be studying other aspects like side effects, efficacy rates, etc., hence it is indirectly supported." -19702373,Gefarnate treats peptic ulcer disease,1317,"One hundred and thirty-nine patients with endoscopically confirmed peptic ulcers (gastric and duodenal) entered a double blind comparative evaluation of alprazolam (1.2 mg/day), gefarnate (300 mg/day) and their combination in treatment of peptic ulcer.",True,"Is the triple 'Gefarnate treats peptic ulcer disease' supported by the sentence: 'One hundred and thirty-nine patients with endoscopically confirmed peptic ulcers (gastric and duodenal) entered a double blind comparative evaluation of alprazolam (1.2 mg/day), gefarnate (300 mg/day) and their combination in treatment of peptic ulcer.'?","Yes, this statement does indirectly support the claim that gefarnate treats peptic ulcer disease. The sentence mentions a double-blind comparative evaluation where patients with endoscopically confirmed peptic ulcers (gastric and duodenal) were given gefarnate (300 mg/day) as part of the study, which suggests that gefarnate was being investigated for its potential in treating peptic ulcers. However, it is important to note that this does not confirm gefarnate as an effective treatment, as further analysis and results from this study would be required to make such a conclusion." -22023951,Regadenoson treats coronary artery disorder,1318,CONCLUSIONS: Regadenoson may be a safe vasodilator for CTP and MR MPI in CAD patients.,True,Is the triple 'Regadenoson treats coronary artery disorder' supported by the sentence: 'CONCLUSIONS: Regadenoson may be a safe vasodilator for CTP and MR MPI in CAD patients.'?,"Yes, this statement can be interpreted as indirect support for the claim. The conclusion mentions Regadenoson as a safe vasodilator for Cardiac Magnetic Resonance (MR) Myocardial Perfusion Imaging (MPI) in Coronary Artery Disease (CAD) patients, which implies it could be used to treat CAD, although it doesn't explicitly state it directly treats the disorder but rather helps in diagnosing it." -13297277,Meldonium treats Ischemic stroke,1319,A study is presented of the clinico-hemodynamic efficacy of mildronate in 38 patients with ischemic stroke.,True,Is the triple 'Meldonium treats Ischemic stroke' supported by the sentence: 'A study is presented of the clinico-hemodynamic efficacy of mildronate in 38 patients with ischemic stroke.'?,"Yes, this statement could indirectly support the claim that Meldonium (also known as mildronate) may have some efficacy in treating ischemic stroke. The sentence indicates that a study was conducted on 38 patients with ischemic stroke, and the drug used in this study was mildronate (which is chemically similar to Meldonium). However, it's important to note that this does not directly prove that Meldonium is an effective treatment for ischemic stroke, as we don't know the specific outcomes of this study, its methodology, or whether it has been peer-reviewed or replicated. Therefore, while there is some suggestive evidence, further research would be needed to definitively support this claim." -25624167,Neobiotic treats pneumonia,1320,Use of neomycin for treatment of Rhodococcus equi pneumonia in foals.,True,Is the triple 'Neobiotic treats pneumonia' supported by the sentence: 'Use of neomycin for treatment of Rhodococcus equi pneumonia in foals.'?,"Yes, this statement does provide indirect support for the claim that neobiotic (a term often used interchangeably with antibiotics, which neomycin is) can treat pneumonia. The sentence explicitly states that neomycin is used for treating Rhodococcus equi pneumonia in foals, which directly supports the idea that neomycin can be used to treat pneumonia, albeit in a specific context (foals with Rhodococcus equi pneumonia). However, it does not directly support the claim that neobiotics generally treat all types of pneumonia, hence the term 'indirectly'." -11022701,Neobiotic treats bacterial infectious disease with sepsis,1321,Osteomyelitis of the cervical vertebras as a complication of urinary tract disease; Proteus bacteremia treated with neomycin.,True,Is the triple 'Neobiotic treats bacterial infectious disease with sepsis' supported by the sentence: 'Osteomyelitis of the cervical vertebras as a complication of urinary tract disease; Proteus bacteremia treated with neomycin.'?,"Yes, there is indirect support for this statement based on the provided sentence. The sentence mentions the use of neomycin to treat Proteus bacteremia, which is a type of blood infection caused by bacteria from the Proteus genus, which falls under Proteobacteria - one class within Bacteria domain (as in Neobiotic treats bacterial infectious diseases). Additionally, osteomyelitis is an infection in bones, which can be considered as severe complication, similar to sepsis, which is systemic inflammatory response to an infection. However, it is important to note that osteomyelitis is not directly mentioned as being treated in this sentence, but it is mentioned as a complication caused by urinary tract infection, which was treated by neomycin, hence, there is an indirect connection to the statement in question." -24398401,BLINATUMOMAB treats B-cell chronic lymphocytic leukemia,1322,Lineage Conversion in Pediatric B-Cell Precursor Acute Leukemia under Blinatumomab Therapy.,False,Is the triple 'BLINATUMOMAB treats B-cell chronic lymphocytic leukemia' supported by the sentence: 'Lineage Conversion in Pediatric B-Cell Precursor Acute Leukemia under Blinatumomab Therapy.'?,"No, this statement is not indirectly supported by the sentence provided. The sentence “Lineage Conversion in Pediatric B-Cell Precursor Acute Leukemia under Blinatumomab Therapy” refers to acute leukemia, not chronic lymphocytic leukemia. Therefore, there is no direct or indirect support for the statement that Blinatumomab treats B-cell chronic lymphocytic leukemia based on this sentence." -23073290,BLINATUMOMAB treats Precursor B-Cell Lymphoblastic Leukemia-Lymphoma,1323,"We report on the Australian experience of blinatumomab for treatment of 24 children with relapsed/refractory precursor B-cell acute lymphoblastic leukaemia (B-ALL) and high-risk genetics, resulting in a minimal residual disease (MRD) response rate of 58%, 2-year progression-free survival (PFS) of 39% and 2-year overall survival of 63%.",True,"Is the triple 'BLINATUMOMAB treats Precursor B-Cell Lymphoblastic Leukemia-Lymphoma' supported by the sentence: 'We report on the Australian experience of blinatumomab for treatment of 24 children with relapsed/refractory precursor B-cell acute lymphoblastic leukaemia (B-ALL) and high-risk genetics, resulting in a minimal residual disease (MRD) response rate of 58%, 2-year progression-free survival (PFS) of 39% and 2-year overall survival of 63%.'?","Yes, the triple statement is indirectly supported by the sentence provided. The sentence mentions a study where blinatumomab was used to treat 24 children with relapsed/refractory precursor B-cell acute lymphoblastic leukemia (B-ALL) and high-risk genetics, resulting in a significant response rate (58% minimal residual disease response rate, 39% 2-year progression-free survival, and 63% 2-year overall survival). This suggests that blinatumomab is an effective treatment for precursor B-Cell Lymphoblastic Leukemia-Lymphoma, which aligns with the triple statement provided, although it does not explicitly mention BLINATUMOMAB treating Lymphoma, it does mention ALL, which is closely related to Lymphoma, thus making it indirectly supported." -21932754,BLINATUMOMAB treats acute lymphoblastic leukemia,1324,"Blinatumomab for Acute Lymphoblastic Leukemia: The First Bispecific T-Cell Engager Antibody to Be Approved by the EMA for Minimal Residual Disease.On November 15, 2018, the Committee for Medicinal Products for Human Use (CHMP) recommended the extension of indication for blinatumomab to include the treatment of adults with minimal residual disease (MRD) positive B-cell precursor acute lymphoblastic leukemia (ALL).",True,"Is the triple 'BLINATUMOMAB treats acute lymphoblastic leukemia' supported by the sentence: 'Blinatumomab for Acute Lymphoblastic Leukemia: The First Bispecific T-Cell Engager Antibody to Be Approved by the EMA for Minimal Residual Disease.On November 15, 2018, the Committee for Medicinal Products for Human Use (CHMP) recommended the extension of indication for blinatumomab to include the treatment of adults with minimal residual disease (MRD) positive B-cell precursor acute lymphoblastic leukemia (ALL).'?","Yes, the sentence does indirectly support the statement that Blinatumomab treats Acute Lymphoblastic Leukemia (ALL). The sentence explicitly states that Blinatumomab has been approved by the EMA for treating adults with minimal residual disease (MRD) positive B-cell precursor ALL, which means Blinatumomab is used to treat ALL patients who have MRD, indicating an ongoing treatment for ALL patients after initial treatment. Therefore, it can be inferred that Blinatumomab plays a role in treating ALL, even if indirectly through managing MRD positive cases." -21720587,BLINATUMOMAB treats lymphoma,1325,"Cytokine storm was reported in four patients (19%).In conclusion, treatment with blinatumomab is effective and tolerable in adult patients with relapsed/refractory B-ALL outside of a clinical trial stetting.",False,"Is the triple 'BLINATUMOMAB treats lymphoma' supported by the sentence: 'Cytokine storm was reported in four patients (19%).In conclusion, treatment with blinatumomab is effective and tolerable in adult patients with relapsed/refractory B-ALL outside of a clinical trial stetting.'?","No, the triple statement is not indirectly supported by this sentence. The sentence mentions that blinatumomab is effective and tolerable in adult patients with relapsed/refractory B-ALL outside of a clinical trial setting, but it does not mention any connection to lymphoma. Therefore, there is no implicit support for the statement that blinatumomab treats lymphoma." -9387116,Ciprofloxacin physically interacts with DNA Gyrase,1326,"UNLABELLED: Ciprofloxacin, a quinolone antibiotic drug, binds to DNA topoisomerase IV and DNA gyrase of various bacteria.",True,"Is the triple 'Ciprofloxacin physically interacts with DNA Gyrase' supported by the sentence: 'UNLABELLED: Ciprofloxacin, a quinolone antibiotic drug, binds to DNA topoisomerase IV and DNA gyrase of various bacteria.'?","Yes, the statement does support the interaction between Ciprofloxacin and DNA Gyrase, albeit indirectly. The sentence states that Ciprofloxacin binds to DNA topoisomerase IV and DNA gyrase in various bacteria, which implies a physical interaction between Ciprofloxacin and DNA Gyrase." -8212496,Ciprofloxacin physically interacts with DNA Gyrase,1327,Topoisomerase IV and DNA gyrase were purified from a ciprofloxacin-sensitive Streptococcus pneumoniae strain and from two clinical isolates of S. pneumoniae with high-level resistance to ciprofloxacin by means of a gene cloning method in Escherichia coli.,True,Is the triple 'Ciprofloxacin physically interacts with DNA Gyrase' supported by the sentence: 'Topoisomerase IV and DNA gyrase were purified from a ciprofloxacin-sensitive Streptococcus pneumoniae strain and from two clinical isolates of S. pneumoniae with high-level resistance to ciprofloxacin by means of a gene cloning method in Escherichia coli.'?,"Yes, the sentence does provide indirect support for the interaction between Ciprofloxacin, DNA Gyrase, and Topoisomerase IV. Ciprofloxacin is known to inhibit bacterial DNA gyrase, which is a type of topoisomerase, thereby inhibiting DNA replication. The fact that both Topoisomerase IV and DNA gyrase were purified from both ciprofloxacin-sensitive and ciprofloxacin-resistant strains of Streptococcus pneumoniae suggests that these proteins interact with Ciprofloxacin, either directly or indirectly, leading to its antibiotic effect. However, it does not directly state that Ciprofloxacin physically interacts with DNA Gyrase, it only implies it through its known mechanism of action." -7781719,Ciprofloxacin affects DNA Gyrase,1328,"The concentrations of ciprofloxacin, sparfloxacin, levofloxacin, or ofloxacin required to inhibit wild-type topoisomerase IV were 8 to 16 times lower than those required to inhibit wild-type DNA gyrase.",True,"Is the triple 'Ciprofloxacin affects DNA Gyrase' supported by the sentence: 'The concentrations of ciprofloxacin, sparfloxacin, levofloxacin, or ofloxacin required to inhibit wild-type topoisomerase IV were 8 to 16 times lower than those required to inhibit wild-type DNA gyrase.'?","Yes, the statement does provide indirect evidence for the idea that Ciprofloxacin affects DNA gyrase. This is because Ciprofloxacin is a type of fluoroquinolone, which is known to target both topoisomerase IV and DNA gyrase. The sentence in question states that lower concentrations of Ciprofloxacin and other fluoroquinolones can inhibit topoisomerase IV compared to DNA gyrase, suggesting that these drugs have a stronger effect on topoisomerase IV. However, this does not mean they do not affect DNA gyrase at all, hence the indirect support for the initial statement." -18400322,Ciprofloxacin affects DNA Gyrase,1329,Plasmid-encoded protein QnrB1 protects DNA gyrase from ciprofloxacin inhibition.,True,Is the triple 'Ciprofloxacin affects DNA Gyrase' supported by the sentence: 'Plasmid-encoded protein QnrB1 protects DNA gyrase from ciprofloxacin inhibition.'?,"Yes, this statement does provide indirect support for the idea that Ciprofloxacin affects DNA gyrase, as it suggests that Ciprofloxacin inhibits DNA gyrase, and QnrB1 provides protection against this inhibition. This implies that Ciprofloxacin does indeed interact with DNA gyrase in some way, thus supporting the initial statement, albeit indirectly." -24010235,Ciprofloxacin treats chronic bronchitis,1330,"Thirty four patients with acute purulent exacerbations of chronic bronchitis were treated with 500 mg ciprofloxacin twice daily, orally, for ten days.",True,"Is the triple 'Ciprofloxacin treats chronic bronchitis' supported by the sentence: 'Thirty four patients with acute purulent exacerbations of chronic bronchitis were treated with 500 mg ciprofloxacin twice daily, orally, for ten days.'?","Yes, this sentence indirectly supports the statement that Ciprofloxacin treats chronic bronchitis. The sentence mentions the use of Ciprofloxacin in treating patients with acute purulent exacerbations of chronic bronchitis, which implies that Ciprofloxacin is used as a treatment for this condition. However, it does not directly state that Ciprofloxacin is used to treat chronic bronchitis itself, hence the term 'indirectly'." -22484062,Ciprofloxacin treats amyotrophic lateral sclerosis,1331,"OBJECTIVE: To evaluate the efficacy of a fixed-dose combination of two approved drugs, Ciprofloxacin and Celecoxib, as a potential therapeutic treatment for amyotrophic lateral sclerosis (ALS).",False,"Is the triple 'Ciprofloxacin treats amyotrophic lateral sclerosis' supported by the sentence: 'OBJECTIVE: To evaluate the efficacy of a fixed-dose combination of two approved drugs, Ciprofloxacin and Celecoxib, as a potential therapeutic treatment for amyotrophic lateral sclerosis (ALS).'?","No, this statement does not indirectly support the claim that Ciprofloxacin treats amyotrophic lateral sclerosis (ALS). The sentence only mentions an ongoing objective to evaluate the efficacy of a fixed-dose combination of Ciprofloxacin and Celecoxib as a potential therapeutic treatment for ALS, but it does not confirm whether this treatment is effective for ALS, let alone Ciprofloxacin alone treating ALS." -21488232,Ciprofloxacin treats Infection,1332,Noncytotoxic Pyrrolobenzodiazepine-Ciprofloxacin Conjugate with Activity against Mycobacterium tuberculosis .The development of new antitubercular agents for the treatment of infections caused by multidrug-resistant (MDR) Mycobacterium tuberculosis is an urgent priority.,False,Is the triple 'Ciprofloxacin treats Infection' supported by the sentence: 'Noncytotoxic Pyrrolobenzodiazepine-Ciprofloxacin Conjugate with Activity against Mycobacterium tuberculosis .The development of new antitubercular agents for the treatment of infections caused by multidrug-resistant (MDR) Mycobacterium tuberculosis is an urgent priority.'?,"No, this sentence does not indirectly support the claim that Ciprofloxacin treats infection. The sentence discusses the development of new antitubercular agents for treating infections caused by multidrug-resistant Mycobacterium tuberculosis, but it does not mention Ciprofloxacin being used to treat any kind of infection directly or indirectly." -20040173,Ciprofloxacin treats lymphoma,1333,Antibacterial prophylaxis with ciprofloxacin for patients with multiple myeloma and lymphoma undergoing autologous haematopoietic cell transplantation: a quasi-experimental single-centre before-after study.,False,Is the triple 'Ciprofloxacin treats lymphoma' supported by the sentence: 'Antibacterial prophylaxis with ciprofloxacin for patients with multiple myeloma and lymphoma undergoing autologous haematopoietic cell transplantation: a quasi-experimental single-centre before-after study.'?,"No, this statement does not indirectly support the claim that Ciprofloxacin treats lymphoma. The study mentioned is about antibacterial prophylaxis using Ciprofloxacin for patients with multiple myeloma and lymphoma undergoing autologous haematopoietic cell transplantation. It does not provide evidence that Ciprofloxacin is used as a treatment for lymphoma." -19067853,Ciprofloxacin treats B-cell chronic lymphocytic leukemia,1334,A case of septic arthritis caused by a Mycoplasma salivarium strain resistant towards Ciprofloxacin and Clarithromycin in a patient with chronic lymphatic leukemia.,False,Is the triple 'Ciprofloxacin treats B-cell chronic lymphocytic leukemia' supported by the sentence: 'A case of septic arthritis caused by a Mycoplasma salivarium strain resistant towards Ciprofloxacin and Clarithromycin in a patient with chronic lymphatic leukemia.'?,"No, this sentence does not indirectly support the statement that Ciprofloxacin treats B-cell chronic lymphocytic leukemia. The sentence discusses a case of septic arthritis in a patient with chronic lymphatic leukemia, caused by a strain of Mycoplasma salivarium resistant to Ciprofloxacin and Clarithromycin. This indicates that Ciprofloxacin was not effective against this particular strain of bacteria in this patient, not that it is a treatment for B-cell chronic lymphocytic leukemia." -14572951,Ciprofloxacin treats hearing loss disorder,1335,Treatment with ciprofloxacin and ceftazidime improved the hearing loss significantly.,False,Is the triple 'Ciprofloxacin treats hearing loss disorder' supported by the sentence: 'Treatment with ciprofloxacin and ceftazidime improved the hearing loss significantly.'?,"No, this sentence does not indirectly support the claim that Ciprofloxacin treats hearing loss disorder. The sentence states that treatment with both Ciprofloxacin and Ceftazidime improved significant hearing loss, but it does not specify which drug was responsible for the improvement in hearing loss. Therefore, it is not possible to attribute this effect specifically to Ciprofloxacin alone based on this sentence." -14398199,Ciprofloxacin treats sinusitis,1336,"CASE SUMMARY: A 24-year-old woman was admitted to the hospital because of convulsions, severe myopathy, and acute renal failure after taking ciprofloxacin for sinusitis, and urinary tract infections.",True,"Is the triple 'Ciprofloxacin treats sinusitis' supported by the sentence: 'CASE SUMMARY: A 24-year-old woman was admitted to the hospital because of convulsions, severe myopathy, and acute renal failure after taking ciprofloxacin for sinusitis, and urinary tract infections.'?","Yes, the sentence does indirectly support the statement that Ciprofloxacin treats sinusitis. The case summary mentions a patient who was taking Ciprofloxacin for sinusitis, which implies that the drug was being used to treat the condition. However, it also mentions severe side effects, which suggests that Ciprofloxacin may not be the best choice for all patients with sinusitis due to potential adverse reactions." -14311974,Ciprofloxacin treats liver abscess (disease),1337,Chromobacterium violaceum endocarditis and hepatic abscesses treated successfully with meropenem and ciprofloxacin.,True,Is the triple 'Ciprofloxacin treats liver abscess (disease)' supported by the sentence: 'Chromobacterium violaceum endocarditis and hepatic abscesses treated successfully with meropenem and ciprofloxacin.'?,"Yes, the sentence does indirectly support the idea that Ciprofloxacin can treat liver abscesses. This is because it mentions a case where Ciprofloxacin was used in conjunction with Meropenem to successfully treat hepatic (liver) abscesses caused by Chromobacterium violaceum endocarditis. However, it's important to note that the effectiveness of Ciprofloxacin in treating liver abscesses may depend on the specific causative organism, as well as other factors such as the severity of the infection and the patient's overall health status." -14284683,Ciprofloxacin treats gastroenteritis,1338,"A patient is reported who had previously maintained a stable prothrombin time on Coumadin for 5 years, and who exhibited a marked prolongation of prothrombin time when placed on ciprofloxacin for gastroenteritis.",True,"Is the triple 'Ciprofloxacin treats gastroenteritis' supported by the sentence: 'A patient is reported who had previously maintained a stable prothrombin time on Coumadin for 5 years, and who exhibited a marked prolongation of prothrombin time when placed on ciprofloxacin for gastroenteritis.'?","Yes, this sentence does indirectly support the statement that Ciprofloxacin treats gastroenteritis. The sentence mentions a patient who was treated with Ciprofloxacin for gastroenteritis and it resulted in a marked prolongation of prothrombin time, which suggests that Ciprofloxacin had an effect on the patient's condition (gastroenteritis). However, it does not directly state that Ciprofloxacin is used to treat gastroenteritis, but it implies it as an antibiotic used to treat infections in the gut, which can be associated with gastroenteritis." -14141218,Ciprofloxacin treats castration-resistant prostate carcinoma,1339,"Doxorubicin and docetaxel, two standard antineoplastic agents in hormone-refractory prostate cancer (HRPC) therapy and ciprofloxacin were evaluated singly and in several simultaneous and sequential drug combination schemes, against PC-3 and LNCaP cell lines.",False,"Is the triple 'Ciprofloxacin treats castration-resistant prostate carcinoma' supported by the sentence: 'Doxorubicin and docetaxel, two standard antineoplastic agents in hormone-refractory prostate cancer (HRPC) therapy and ciprofloxacin were evaluated singly and in several simultaneous and sequential drug combination schemes, against PC-3 and LNCaP cell lines.'?","No, this sentence does not indirectly support the statement that Ciprofloxacin treats castration-resistant prostate carcinoma. The sentence only mentions that Ciprofloxacin was evaluated along with other drugs against PC-3 and LNCaP cell lines, which are prostate cancer cell lines, but it does not specify the type of prostate cancer, nor does it mention any therapeutic effect. Castration-resistant prostate carcinoma is a specific type of prostate cancer, and the sentence does not provide any information about this specific type." -14005051,Ciprofloxacin treats acute myeloid leukemia,1340,"Results of combination therapy with amifostine, pentoxifylline, ciprofloxacin and dexamethasone in patients with myelodysplastic syndrome and acute myeloid leukemia.",False,"Is the triple 'Ciprofloxacin treats acute myeloid leukemia' supported by the sentence: 'Results of combination therapy with amifostine, pentoxifylline, ciprofloxacin and dexamethasone in patients with myelodysplastic syndrome and acute myeloid leukemia.'?","No, this statement does not indirectly support the claim that Ciprofloxacin treats acute myeloid leukemia. The sentence you provided mentions Ciprofloxacin being used in combination therapy for patients with myelodysplastic syndrome and acute myeloid leukemia, but it does not specify that Ciprofloxacin itself has any therapeutic effect on acute myeloid leukemia. It could be that Ciprofloxacin is used to manage some secondary symptom or side effect, not the leukemia itself. Therefore, we cannot infer from this sentence that Ciprofloxacin is a treatment for acute myeloid leukemia." -13846017,Ciprofloxacin treats lung disorder,1341,High dose parenteral ciprofloxacin in pleuro-pulmonary disease: a comparative pharmacolinetics of 400 and 200 mg intravenous.,False,Is the triple 'Ciprofloxacin treats lung disorder' supported by the sentence: 'High dose parenteral ciprofloxacin in pleuro-pulmonary disease: a comparative pharmacolinetics of 400 and 200 mg intravenous.'?,"No, this sentence does not indirectly support the statement that Ciprofloxacin treats lung disorders. The sentence only discusses the pharmacokinetics of Ciprofloxacin in pleuro-pulmonary disease, which refers to diseases involving the pleura (the membrane surrounding the lungs) and the lungs themselves. It does not provide any information about Ciprofloxacin's effectiveness in treating these diseases." -13663890,Ciprofloxacin treats otitis media,1342,[Pneumococcal meningitis during ciprofloxacin therapy for otitis media].,True,Is the triple 'Ciprofloxacin treats otitis media' supported by the sentence: '[Pneumococcal meningitis during ciprofloxacin therapy for otitis media].'?,"Yes, this statement could indirectly support the idea that Ciprofloxacin can treat otitis media, as it mentions ciprofloxacin therapy being used for otitis media, even though it also mentions pneumococcal meningitis occurring during this therapy. However, it is important to note that Ciprofloxacin is not typically used as a first-line treatment for otitis media due to potential side effects, including pneumococcal meningitis, especially in children. It is more commonly used for more serious infections, such as pneumococcal meningitis, due to its broad-spectrum antibacterial activity." -11840711,Ciprofloxacin treats cataract,1343,"CONCLUSIONS: Ofloxacin has higher corneal penetration and ability to exceed MIC90 of common ocular contaminants than ciprofloxacin, and would be a more appropriate prophylactic choice for canine cataract patients.",False,"Is the triple 'Ciprofloxacin treats cataract' supported by the sentence: 'CONCLUSIONS: Ofloxacin has higher corneal penetration and ability to exceed MIC90 of common ocular contaminants than ciprofloxacin, and would be a more appropriate prophylactic choice for canine cataract patients.'?","No, this sentence does not indirectly support the claim that Ciprofloxacin treats cataract in any way. The sentence is discussing the comparative effectiveness of Ofloxacin and Ciprofloxacin in preventing ocular infections in canine patients undergoing cataract surgery, not treating cataracts themselves." -11684450,Ciprofloxacin treats cystitis,1344,Amoxicillin-clavulanate vs ciprofloxacin for the treatment of uncomplicated cystitis in women: a randomized trial.,True,Is the triple 'Ciprofloxacin treats cystitis' supported by the sentence: 'Amoxicillin-clavulanate vs ciprofloxacin for the treatment of uncomplicated cystitis in women: a randomized trial.'?,"Yes, this statement is indirectly supported by the sentence provided. The sentence mentions a randomized trial comparing Amoxicillin-clavulanate to Ciprofloxacin for treating uncomplicated cystitis in women, which implies Ciprofloxacin is used to treat cystitis, which aligns with the statement Ciprofloxacin treats cystitis. However, it does not directly state Ciprofloxacin is used to treat cystitis, hence it is indirect support." -11679354,Ciprofloxacin treats Pseudomonas infection,1345,We used a simple Wood's light examination and culture to establish the diagnosis of Pseudomonas toe web infection and achieved rapid resolution with oral ciprofloxacin treatment and local application of Castellani's paint.,True,Is the triple 'Ciprofloxacin treats Pseudomonas infection' supported by the sentence: 'We used a simple Wood's light examination and culture to establish the diagnosis of Pseudomonas toe web infection and achieved rapid resolution with oral ciprofloxacin treatment and local application of Castellani's paint.'?,"Yes, this statement does indirectly support the claim that Ciprofloxacin treats Pseudomonas infection. The statement mentions using Ciprofloxacin to treat a diagnosed case of Pseudomonas toe web infection, which was confirmed through Wood's light examination and culture. The fact that they achieved rapid resolution suggests that Ciprofloxacin was effective against the Pseudomonas infection, providing indirect evidence for the claim." -11628762,Ciprofloxacin treats endophthalmitis,1346,Ciprofloxacin in endophthalmitis: an alternative to ceftazidime and amikacin!,True,Is the triple 'Ciprofloxacin treats endophthalmitis' supported by the sentence: 'Ciprofloxacin in endophthalmitis: an alternative to ceftazidime and amikacin!'?,"Yes, this statement can be seen as indirectly supporting the idea that Ciprofloxacin can treat endophthalmitis. The title ""Ciprofloxacin in endophthalmitis: an alternative to ceftazidime and amikacin!"" suggests that Ciprofloxacin is indeed used in treating endophthalmitis, although it may not be the first choice compared to ceftazidime and amikacin. However, it is important to note that this is an indirect inference, as the original sentence does not directly state that Ciprofloxacin is used to treat endophthalmitis, but rather mentions it as an alternative treatment option in a specific context." -11564697,Ciprofloxacin treats chronic obstructive pulmonary disease,1347,Reported here is the case of a patient with underlying chronic obstructive pulmonary disease (COPD) in whom ciprofloxacin treatment of a lower respiratory tract infection failed subsequent to ciprofloxacin treatment of an exacerbation of COPD several weeks earlier.,False,Is the triple 'Ciprofloxacin treats chronic obstructive pulmonary disease' supported by the sentence: 'Reported here is the case of a patient with underlying chronic obstructive pulmonary disease (COPD) in whom ciprofloxacin treatment of a lower respiratory tract infection failed subsequent to ciprofloxacin treatment of an exacerbation of COPD several weeks earlier.'?,"No, this sentence does not support the claim that Ciprofloxacin treats chronic obstructive pulmonary disease (COPD). In fact, it suggests the opposite. The sentence describes a patient with COPD who was treated with Ciprofloxacin for a lower respiratory tract infection, but the treatment failed. This implies that Ciprofloxacin may not be effective in treating COPD or its complications." -11304087,Ciprofloxacin treats eye infectious disorder,1348,This PK-MB model may be very useful in optimizing treatments of various eye infections with ciprofloxacin.,True,Is the triple 'Ciprofloxacin treats eye infectious disorder' supported by the sentence: 'This PK-MB model may be very useful in optimizing treatments of various eye infections with ciprofloxacin.'?,"Yes, this is indirectly supported because both statements suggest a relationship between Ciprofloxacin (an antibiotic) and treating various eye infections, but they do not explicitly state that Ciprofloxacin is used to treat eye infections caused by infectious disorders specifically. The second statement suggests that optimizing treatments for various eye infections using a PK-MB model can be done using Ciprofloxacin, which implies its use in treating some form of eye infections, but it doesn't directly mention infectious disorders." -11059709,Ciprofloxacin treats abscess,1349,"The patient was asymptomatic for a month, but the abscess reactivated and was treated with Vancomycin and Ciprofloxacin administered intravenously.",False,"Is the triple 'Ciprofloxacin treats abscess' supported by the sentence: 'The patient was asymptomatic for a month, but the abscess reactivated and was treated with Vancomycin and Ciprofloxacin administered intravenously.'?","No, this sentence does not indirectly support that Ciprofloxacin treats an abscess. The sentence only states that Ciprofloxacin was used in treatment when the abscess reactivated, but it does not imply that Ciprofloxacin was responsible for treating the abscess. Vancomycin was also administered intravenously, so it is unclear which antibiotic was responsible for treating the reactivated abscess." -10087799,Ciprofloxacin treats bacterial infectious disease,1350,"Fluoroquinolones such as ciprofloxacin, levofloxacin, moxifloxacin and gatifloxacin are widely used for the treatment of bacterial infections.",True,"Is the triple 'Ciprofloxacin treats bacterial infectious disease' supported by the sentence: 'Fluoroquinolones such as ciprofloxacin, levofloxacin, moxifloxacin and gatifloxacin are widely used for the treatment of bacterial infections.'?","Yes, this is indirectly supported. The sentence mentions Ciprofloxacin as part of the Fluoroquinolones group, which is widely used for treating bacterial infections. This implies that Ciprofloxacin, being a Fluoroquinolone, is also used for treating bacterial infections, thus treating bacterial infectious diseases." -10013051,Ciprofloxacin treats plague,1351,There are no previous reports of plague being successfully treated with ciprofloxacin.,False,Is the triple 'Ciprofloxacin treats plague' supported by the sentence: 'There are no previous reports of plague being successfully treated with ciprofloxacin.'?,"No, this statement does not support the claim that ciprofloxacin treats plague. In fact, it suggests the opposite, as there are no previous reports of successful treatment of plague with ciprofloxacin. This could imply that ciprofloxacin is not an effective treatment for plague." -10002223,Ciprofloxacin treats anthrax infection,1352,Treatment and post-exposure prophylaxis for anthrax are ciprofloxacin or doxycycline.,True,Is the triple 'Ciprofloxacin treats anthrax infection' supported by the sentence: 'Treatment and post-exposure prophylaxis for anthrax are ciprofloxacin or doxycycline.'?,"Yes, this statement does indirectly support the claim that Ciprofloxacin can be used to treat Anthrax infection. The sentence mentions Ciprofloxacin as an option for both treatment and post-exposure prophylaxis for Anthrax, which suggests its efficacy in dealing with Anthrax infections. However, it is important to note that it also mentions Doxycycline as an alternative, which means Ciprofloxacin is not the only treatment option for Anthrax infection." -9704134,Ciprofloxacin treats bronchiectasis,1353,"He had severe airway obstruction and focal bronchiectasis, and responded to treatment with ciprofloxacin and clarithromycin.",True,"Is the triple 'Ciprofloxacin treats bronchiectasis' supported by the sentence: 'He had severe airway obstruction and focal bronchiectasis, and responded to treatment with ciprofloxacin and clarithromycin.'?","Yes, this statement does indirectly support the idea that Ciprofloxacin can treat Bronchiectasis. The patient had severe airway obstruction and focal Bronchiectasis, which indicates a bacterial infection in the airways, possibly due to Bronchiectasis. The patient responded to treatment with Ciprofloxacin, an antibiotic commonly used to treat infections caused by bacteria, including those associated with Bronchiectasis. Therefore, it can be inferred that Ciprofloxacin was effective in treating the patient's Bronchiectasis-related infection, even though Clarithromycin was also used in combination." -9552171,Ciprofloxacin treats otitis externa,1354,"The objective of this study was to evaluate and compare the efficacy of topical otic powder, tobramycin drops and ciprofloxacin drops in patients suffering from AEO.",True,"Is the triple 'Ciprofloxacin treats otitis externa' supported by the sentence: 'The objective of this study was to evaluate and compare the efficacy of topical otic powder, tobramycin drops and ciprofloxacin drops in patients suffering from AEO.'?","Yes, this statement does indirectly support the idea that Ciprofloxacin treats otitis externa (AEO). The study mentioned aims to evaluate and compare the efficacy of Ciprofloxacin drops among other treatments for AEO, implying its use as a treatment option for this condition. However, it does not directly state that Ciprofloxacin is used to treat AEO, but rather it is being studied for its efficacy in treating AEO." -9504629,Ciprofloxacin treats Sepsis,1355,Ciprofloxacin pharmacokinetic profiles in paediatric sepsis: how much ciprofloxacin is enough?,False,Is the triple 'Ciprofloxacin treats Sepsis' supported by the sentence: 'Ciprofloxacin pharmacokinetic profiles in paediatric sepsis: how much ciprofloxacin is enough?'?,"No, this statement is not indirectly supported by the provided sentence. The sentence discusses pharmacokinetic profiles of Ciprofloxacin in paediatric sepsis, but it does not mention or imply that Ciprofloxacin is used to treat sepsis." -9281470,Ciprofloxacin treats prostatitis,1356,The emergence and evolution of quinolone-resistant Escherichia coli in faeces of patients with prostatitis treated with high-dose oral ciprofloxacin for 1 month were studied.,True,Is the triple 'Ciprofloxacin treats prostatitis' supported by the sentence: 'The emergence and evolution of quinolone-resistant Escherichia coli in faeces of patients with prostatitis treated with high-dose oral ciprofloxacin for 1 month were studied.'?,"Yes, this sentence does provide indirect support for the statement ""Ciprofloxacin treats prostatitis"". The sentence discusses a study where patients with prostatitis were treated with high-dose oral Ciprofloxacin for a month, which suggests that Ciprofloxacin is used as a treatment for prostatitis. However, it doesn't directly state that Ciprofloxacin treats prostatitis, hence the term 'indirectly'. The study is more focused on the emergence and evolution of quinolone-resistant Escherichia coli in these patients, which is a potential side effect of such treatment." -8956827,Ciprofloxacin treats Abdominal Infection,1357,"Ciprofloxacin is effective in the treatment of serious, non-self-limiting intra-abdominal infections, peritonitis in CAPD, pelvic inflammatory disease, endometritis and gall-bladder infections.",True,"Is the triple 'Ciprofloxacin treats Abdominal Infection' supported by the sentence: 'Ciprofloxacin is effective in the treatment of serious, non-self-limiting intra-abdominal infections, peritonitis in CAPD, pelvic inflammatory disease, endometritis and gall-bladder infections.'?","Yes, this statement does indirectly support that Ciprofloxacin can treat abdominal infections, as it specifically mentions its effectiveness in treating serious, non-self-limiting intra-abdominal infections, which would include abdominal infections. The other conditions mentioned, such as peritonitis in CAPD, pelvic inflammatory disease, endometritis, and gall-bladder infections, also involve areas within the abdomen, further supporting this claim." -8754779,Ciprofloxacin treats rhinoscleroma,1358,We report on a young patient with nasal rhinoscleroma who achieved resolution after treatment with oral ciprofloxacin.,True,Is the triple 'Ciprofloxacin treats rhinoscleroma' supported by the sentence: 'We report on a young patient with nasal rhinoscleroma who achieved resolution after treatment with oral ciprofloxacin.'?,"Yes, this statement does indirectly support the claim that Ciprofloxacin can treat rhinoscleroma. The sentence mentions a case where a patient with nasal rhinoscleroma was treated with oral Ciprofloxacin and achieved resolution, which suggests that Ciprofloxacin may be an effective treatment for this condition. However, it's important to note that this is based on a single case study, so further research would be needed to confirm this finding." -8350437,Ciprofloxacin treats pyelonephritis,1359,Is a 7-day course of ciprofloxacin effective in the treatment of uncomplicated pyelonephritis in women?,True,Is the triple 'Ciprofloxacin treats pyelonephritis' supported by the sentence: 'Is a 7-day course of ciprofloxacin effective in the treatment of uncomplicated pyelonephritis in women?'?,"Yes, this statement does provide indirect support for the claim that Ciprofloxacin treats pyelonephritis in women. The sentence states that a 7-day course of Ciprofloxacin is effective in treating uncomplicated pyelonephritis in women, which implies that Ciprofloxacin is indeed used to treat this condition. However, it should be noted that this is an indirect inference, as the sentence does not explicitly state that Ciprofloxacin is used to treat pyelonephritis, but rather implies it through its description of an effective treatment regimen." -8337570,Ciprofloxacin treats bacterial infectious disease with sepsis,1360,"Despite prolonged bacteremia, the response to long-term therapy with ciprofloxacin and rifampin was excellent.",True,"Is the triple 'Ciprofloxacin treats bacterial infectious disease with sepsis' supported by the sentence: 'Despite prolonged bacteremia, the response to long-term therapy with ciprofloxacin and rifampin was excellent.'?","Yes, this statement does indirectly support the claim that Ciprofloxacin can treat bacterial infectious diseases, including those associated with sepsis, given its use in combination with rifampin led to an excellent response in a patient despite prolonged bacteremia (bacteria in the bloodstream). Bacteremia is often associated with sepsis, which is a serious condition caused by infection throughout the body. The efficacy of Ciprofloxacin in this situation implies its ability to combat bacterial infections, even in severe cases like sepsis, although it is essential to note that it was used in conjunction with another antibiotic, rifampin, which may have contributed to the successful outcome." -8194797,Ciprofloxacin treats neutropenia,1361,The proportion of patients who developed neutropenia and fever was 87% in the group treated with ciprofloxacin and 78% in the group treated with ciprofloxacin and rifampin (P =.25).,False,Is the triple 'Ciprofloxacin treats neutropenia' supported by the sentence: 'The proportion of patients who developed neutropenia and fever was 87% in the group treated with ciprofloxacin and 78% in the group treated with ciprofloxacin and rifampin (P =.25).'?,"No, this sentence does not indirectly support that Ciprofloxacin treats neutropenia. In fact, it suggests that there is no significant difference in the incidence of neutropenia between patients treated with ciprofloxacin alone and those treated with both ciprofloxacin and rifampin (P =.25). This indicates that adding rifampin to ciprofloxacin does not reduce the incidence of neutropenia, which is not consistent with the idea that Ciprofloxacin treats neutropenia." -8190776,Ciprofloxacin treats peritonitis,1362,"Peritonitis due to S. aureus ESI was significantly less frequent among patients treated with ciprofloxacin (1 vs 9 cases, p = 0.001).",True,"Is the triple 'Ciprofloxacin treats peritonitis' supported by the sentence: 'Peritonitis due to S. aureus ESI was significantly less frequent among patients treated with ciprofloxacin (1 vs 9 cases, p = 0.001).'?","Yes, the statement does provide indirect support for the claim that Ciprofloxacin can treat Peritonitis due to S. Aureus ESI (Extended Spectrum Intravenous Antibiotics). The sentence indicates that patients treated with Ciprofloxacin had significantly fewer cases of Peritonitis due to S. Aureus ESI, suggesting its efficacy in treating this condition. However, it's important to note that this is an indirect inference, as the sentence doesn't explicitly state that Ciprofloxacin treats Peritonitis due to S. Aureus ESI, but rather implies it based on the observed outcomes." -8088120,Ciprofloxacin treats Fever,1363,"In the current study, the authors examined the use of ciprofloxacin as outpatient management in selected patients with fever during an episode of neutropenia.",False,"Is the triple 'Ciprofloxacin treats Fever' supported by the sentence: 'In the current study, the authors examined the use of ciprofloxacin as outpatient management in selected patients with fever during an episode of neutropenia.'?","No, this statement does not indirectly support the claim that Ciprofloxacin treats fever. The sentence only mentions that Ciprofloxacin was used in managing fever during neutropenia, but it does not imply that Ciprofloxacin is used to treat fever itself." -7880629,Ciprofloxacin treats osteomyelitis,1364,"The efficacy and safety of three oral fluoroquinolones (lomefloxacin, levofloxacin, and ciprofloxacin) for the treatment of chronic osteomyelitis were analyzed.",True,"Is the triple 'Ciprofloxacin treats osteomyelitis' supported by the sentence: 'The efficacy and safety of three oral fluoroquinolones (lomefloxacin, levofloxacin, and ciprofloxacin) for the treatment of chronic osteomyelitis were analyzed.'?","Yes, the sentence does indirectly support the statement that Ciprofloxacin treats osteomyelitis. The sentence mentions Ciprofloxacin as one of the oral fluoroquinolones analyzed for the treatment of chronic osteomyelitis, which suggests that it is used in treating this condition. However, it does not explicitly state that Ciprofloxacin is used alone in treating osteomyelitis, so it is an indirect support." -7798648,Ciprofloxacin treats cystic fibrosis,1365,"As juveniles are especially sensitive, use of these drugs in paediatrics should be restricted to carefully selected indications (such as the use of ciprofloxacin in cystic fibrosis).",False,"Is the triple 'Ciprofloxacin treats cystic fibrosis' supported by the sentence: 'As juveniles are especially sensitive, use of these drugs in paediatrics should be restricted to carefully selected indications (such as the use of ciprofloxacin in cystic fibrosis).'?","No, this statement does not directly support the idea that Ciprofloxacin treats cystic fibrosis, but it does indirectly support Ciprofloxacin as an appropriate medication for treating patients with cystic fibrosis under specific conditions, such as when other medications have proven ineffective. This is because it suggests that Ciprofloxacin can be used in pediatric cases of cystic fibrosis, which implies its potential therapeutic value for this condition, but it does not confirm it as a treatment for this disease." -7544699,Ciprofloxacin treats diarrheal disease,1366,The aim of this study was to investigate clinical importance of ciprofloxacin efficacy in treatment of massive diarrhoea in patients after extensional bowel resection with removing of ileo-coecal valve (EBR + ICVR).,False,Is the triple 'Ciprofloxacin treats diarrheal disease' supported by the sentence: 'The aim of this study was to investigate clinical importance of ciprofloxacin efficacy in treatment of massive diarrhoea in patients after extensional bowel resection with removing of ileo-coecal valve (EBR + ICVR).'?,"No, this sentence does not indirectly support the claim that Ciprofloxacin treats diarrheal disease. The sentence is discussing a study about the clinical importance of Ciprofloxacin efficacy in treating massive diarrhea in specific patients, but it does not confirm that Ciprofloxacin is an effective treatment for diarrheal disease in general." -7423320,Ciprofloxacin treats typhoid fever,1367,"To compare clinical and bacteriological efficacies of azithromycin and ciprofloxacin for typhoid fever, 123 adults with fever and signs of uncomplicated typhoid fever were entered into a randomized trial.",True,"Is the triple 'Ciprofloxacin treats typhoid fever' supported by the sentence: 'To compare clinical and bacteriological efficacies of azithromycin and ciprofloxacin for typhoid fever, 123 adults with fever and signs of uncomplicated typhoid fever were entered into a randomized trial.'?","Yes, this is indirectly supported by the sentence provided. The sentence mentions a randomized trial comparing clinical and bacteriological efficacies of azithromycin and ciprofloxacin for uncomplicated typhoid fever, which indicates that ciprofloxacin is used to treat typhoid fever in this context. However, it does not directly state that ciprofloxacin is effective in treating typhoid fever, which is what the original statement implies." -7337248,Ciprofloxacin treats pneumonia,1368,Initial treatment of severe pneumonia with ciprofloxacin resulted in significantly less subsequent gram-negative infection and was associated with substantially lower curative costs.,True,Is the triple 'Ciprofloxacin treats pneumonia' supported by the sentence: 'Initial treatment of severe pneumonia with ciprofloxacin resulted in significantly less subsequent gram-negative infection and was associated with substantially lower curative costs.'?,"Yes, this sentence does indirectly support the statement that Ciprofloxacin treats pneumonia. The sentence mentions that initial treatment of severe pneumonia with Ciprofloxacin resulted in significantly less subsequent gram-negative infection. This implies that Ciprofloxacin is effective in treating pneumonia, as it reduces the occurrence of further infections, which is a complication often associated with pneumonia. The association with lower curative costs also suggests that Ciprofloxacin could be a cost-effective treatment option for pneumonia. However, it is important to note that this is an indirect inference, as the sentence does not directly state that Ciprofloxacin is used to treat pneumonia, but rather implies it through its effects on subsequent infections." -7228759,Ciprofloxacin treats infectious disease,1369,"Ciprofloxacin (CIP), a fluoroquinolone antibacterial drug, is widely used in the treatment of serious infections in humans.",True,"Is the triple 'Ciprofloxacin treats infectious disease' supported by the sentence: 'Ciprofloxacin (CIP), a fluoroquinolone antibacterial drug, is widely used in the treatment of serious infections in humans.'?","Yes, indirectly supported because Ciprofloxacin is an antibacterial drug used to treat serious infections, which implies it helps in managing and treating infectious diseases caused by bacteria." -7163480,Ciprofloxacin treats Crohn disease,1370,Use of antibiotics in the treatment of active Crohn's disease: experience with metronidazole and ciprofloxacin.,True,Is the triple 'Ciprofloxacin treats Crohn disease' supported by the sentence: 'Use of antibiotics in the treatment of active Crohn's disease: experience with metronidazole and ciprofloxacin.'?,"Yes, this statement does indirectly support the idea that Ciprofloxacin can be used to treat Crohn disease. The sentence mentions the use of Ciprofloxacin in treating active Crohn's disease, which directly implies its application in managing this medical condition. However, it is important to note that this statement does not provide direct evidence on how effective Ciprofloxacin is in treating Crohn disease, nor does it discuss any potential side effects or risks associated with its use in this context." -10607698,Chloramphenicol treats bacterial infectious disease,1371,[Experiences with a chloramphenicol preparation for intramuscular injection in bacterial infections of the CNS].,True,Is the triple 'Chloramphenicol treats bacterial infectious disease' supported by the sentence: '[Experiences with a chloramphenicol preparation for intramuscular injection in bacterial infections of the CNS].'?,"Yes, this statement can be seen as indirectly supporting the claim that Chloramphenicol can treat bacterial infections, given that it mentions its use in treating bacterial infections in the Central Nervous System (CNS). However, it does not explicitly state that Chloramphenicol is effective against these infections, nor does it mention any specific results from its use in treatment, so it does not provide direct evidence for its effectiveness against such infections." -9528501,Chloramphenicol treats osteomyelitis,1372,A 2-month-old infant with Enterobacter osteomyelitis complicating total parenteral nutrition was successfully treated with rifampicin and chloramphenicol.,True,Is the triple 'Chloramphenicol treats osteomyelitis' supported by the sentence: 'A 2-month-old infant with Enterobacter osteomyelitis complicating total parenteral nutrition was successfully treated with rifampicin and chloramphenicol.'?,"Yes, this statement indirectly supports the triple statement ""Chloramphenicol treats osteomyelitis."" The sentence mentions an infant being successfully treated for Enterobacter osteomyelitis using chloramphenicol, which suggests its efficacy in treating this condition. However, it does not directly address whether Chloramphenicol is effective in treating osteomyelitis caused specifically by Staphylococcus aureus, which is often associated with this antibiotic in clinical contexts." -7351604,Chloramphenicol treats eye infectious disorder,1373,"The writers consult a wide range of American, European and British research from 1950 to the present to reassure readers that ophthalmic chloramphenicol is a demonstrably effective, safe, cost-effective treatment for most superficial eye infections.",True,"Is the triple 'Chloramphenicol treats eye infectious disorder' supported by the sentence: 'The writers consult a wide range of American, European and British research from 1950 to the present to reassure readers that ophthalmic chloramphenicol is a demonstrably effective, safe, cost-effective treatment for most superficial eye infections.'?","Yes, this statement does indirectly support the claim that Chloramphenicol can be used to treat an eye infection, as it mentions ophthalmic chloramphenicol as an effective, safe, and cost-effective treatment for most superficial eye infections, which is backed up by research from 1950 to present from American, European, and British sources. However, it does not directly state that Chloramphenicol can treat all types of eye infections, nor does it specifically mention infectious disorders, so it is not a direct support, but rather an indirect one based on its general effectiveness against superficial eye infections as mentioned in research from various sources over several decades." -24500158,Rebamipide treats gastroesophageal reflux disease,1374,Frequently reported adverse events of rebamipide compared to other drugs for peptic ulcer and gastroesophageal reflux disease.,False,Is the triple 'Rebamipide treats gastroesophageal reflux disease' supported by the sentence: 'Frequently reported adverse events of rebamipide compared to other drugs for peptic ulcer and gastroesophageal reflux disease.'?,"No, this sentence does not provide direct or indirect support for the statement that Rebamipide treats gastroesophageal reflux disease (GERD). The sentence only mentions that rebamipide has frequently reported adverse events compared to other drugs for peptic ulcer and GERD. It does not confirm the therapeutic effect of rebamipide on GERD, nor does it provide any correlation between rebamipide and the treatment of GERD." -19949890,Rebamipide treats osteoarthritis,1375,We also discuss the potential role of rebamipide to serve as a new strategy for the treatment of TMJ-OA.,True,Is the triple 'Rebamipide treats osteoarthritis' supported by the sentence: 'We also discuss the potential role of rebamipide to serve as a new strategy for the treatment of TMJ-OA.'?,"Yes, this statement can be interpreted as indirectly supporting the claim that Rebamipide treats osteoarthritis (OA), specifically temporomandibular joint osteoarthritis (TMJ-OA). The sentence suggests that Rebamipide could potentially be used as a new strategy for treating TMJ-OA, implying its therapeutic effect on OA. However, it is important to note that this is an indirect inference, as the sentence does not directly state that Rebamipide treats OA, but rather implies it in the context of TMJ-OA treatment strategies." -19364844,Rebamipide treats dry eye syndrome,1376,CONCLUSIONS: REB and DQS may be effective for the management of dry eye syndrome after PK in terms of ocular surface findings.,True,Is the triple 'Rebamipide treats dry eye syndrome' supported by the sentence: 'CONCLUSIONS: REB and DQS may be effective for the management of dry eye syndrome after PK in terms of ocular surface findings.'?,"Yes, this statement can be interpreted as indirectly supporting the claim that Rebamipide (REB) can treat dry eye syndrome (DES). The conclusion mentions that REB may be effective for managing DES after photorefractive keratectomy (PK) in terms of ocular surface findings. This suggests that REB could have a therapeutic effect on DES, which aligns with the claim, although it does not explicitly state that Rebamipide treats DES, but rather it may be effective for management, which could include treatment." -13211904,Rebamipide treats ulcerative colitis,1377,"OBJECTIVE AND DESIGN: Since rebamipide is effective for the treatment of ulcerative colitis (UC), we examined the involvement of hepatocyte growth factor (HGF) in the action of rebamipide.",True,"Is the triple 'Rebamipide treats ulcerative colitis' supported by the sentence: 'OBJECTIVE AND DESIGN: Since rebamipide is effective for the treatment of ulcerative colitis (UC), we examined the involvement of hepatocyte growth factor (HGF) in the action of rebamipide.'?","Yes, this sentence does indirectly support the statement that rebamipide treats ulcerative colitis (UC). The sentence mentions that rebamipide is effective for the treatment of UC, which aligns with the first part of the statement. However, it doesn't directly mention that rebamipide treats ulcerative colitis, but rather it states that it is effective, which is a form of treatment. The second part of the sentence discusses an examination of hepatocyte growth factor (HGF) involvement in rebamipide's action, but this is not directly related to the statement in question." -12062800,Rebamipide treats peptic ulcer disease,1378,"Rebamipide, a gastro-protective drug, was developed in Japan for the treatment of peptic ulcer disease.",True,"Is the triple 'Rebamipide treats peptic ulcer disease' supported by the sentence: 'Rebamipide, a gastro-protective drug, was developed in Japan for the treatment of peptic ulcer disease.'?","Yes, this is indirectly supported. The statement ""Rebamipide, a gastro-protective drug, was developed in Japan for the treatment of peptic ulcer disease."" implies that Rebamipide is used to treat peptic ulcer disease, which is a type of gastrointestinal condition. Therefore, it can be inferred that Rebamipide, being a gastro-protective drug, would help in treating peptic ulcers, thus providing at least indirect support to the statement ""Rebamipide treats peptic ulcer disease""." -10368387,Rebamipide treats gastric ulcer,1379,Rebamipide is a mucoprotective drug used for the treatment of gastric ulcers.,True,Is the triple 'Rebamipide treats gastric ulcer' supported by the sentence: 'Rebamipide is a mucoprotective drug used for the treatment of gastric ulcers.'?,"Yes, this statement is indirectly supported by the provided sentence. The sentence states that Rebamipide is a mucoprotective drug, which means it protects the mucous membrane in the stomach, thereby potentially treating gastric ulcers. Therefore, it can be inferred that Rebamipide is used for treating gastric ulcers, even though the sentence does not explicitly state this fact." -8102739,Rebamipide treats gastritis,1380,"In conclusion, rebamipide may attenuate H. pylori-induced gastric inflammation by inhibiting lipid peroxidation and oxidant-mediated activation of NF-kappaB and thereby decreasing IL-8 production.",True,"Is the triple 'Rebamipide treats gastritis' supported by the sentence: 'In conclusion, rebamipide may attenuate H. pylori-induced gastric inflammation by inhibiting lipid peroxidation and oxidant-mediated activation of NF-kappaB and thereby decreasing IL-8 production.'?","Yes, this sentence does indirectly support the statement ""Rebamipide treats gastritis."" The sentence mentions rebamipide may attenuate H. pylori-induced gastric inflammation, which is a primary cause of gastritis. By inhibiting lipid peroxidation and oxidant-mediated activation of NF-kappaB, rebamipide decreases IL-8 production, which is associated with reduced inflammation in the stomach lining, thus potentially treating gastritis." -27610972,DINUTUXIMAB treats bone osteosarcoma,1381,Phase I trial of a human-mouse chimeric anti-disialoganglioside monoclonal antibody ch14.18 in patients with refractory neuroblastoma and osteosarcoma.,False,Is the triple 'DINUTUXIMAB treats bone osteosarcoma' supported by the sentence: 'Phase I trial of a human-mouse chimeric anti-disialoganglioside monoclonal antibody ch14.18 in patients with refractory neuroblastoma and osteosarcoma.'?,"No, this sentence does not indirectly support the statement that DINUTUXIMAB treats bone osteosarcoma. The sentence mentions a phase I trial of a human-mouse chimeric anti-disialoganglioside monoclonal antibody (ch14.18) in patients with refractory neuroblastoma and osteosarcoma. However, it does not specify that DINUTUXIMAB was used in this trial, nor does it state that it is effective in treating bone osteosarcoma. DINUTUXIMAB is an anti-GD2 monoclonal antibody, not anti-disialoganglioside, although disialoganglioside is sometimes referred to as GD2 in scientific literature. Therefore, without additional information, we cannot infer any relationship between DINUTUXIMAB and the treatment of bone osteosarcoma from this sentence." -21740095,DINUTUXIMAB treats neoplasm,1382,Tumors treated with local dinutuximab had decreased MYCN expression on histology compared to control or IgG-treated tumors.,True,Is the triple 'DINUTUXIMAB treats neoplasm' supported by the sentence: 'Tumors treated with local dinutuximab had decreased MYCN expression on histology compared to control or IgG-treated tumors.'?,"Yes, this statement does indirectly support the idea that Dinutuximab treats neoplasms (a type of tumor). The sentence states that tumors treated with Dinutuximab had decreased MYCN expression on histology compared to control or IgG-treated tumors. This suggests that Dinutuximab has an effect on tumors, potentially reducing their growth or progression, which is in line with the concept of treating neoplasms. However, it's important to note that this is an indirect inference, as the sentence doesn't explicitly state that Dinutuximab is used for treating neoplasms, but rather implies it through its effects on tumor histology." -9445080,DINUTUXIMAB treats neuroblastoma,1383,Ocular symptoms in children treated with human-mouse chimeric anti-GD2 mAb ch14.18 for neuroblastoma.,False,Is the triple 'DINUTUXIMAB treats neuroblastoma' supported by the sentence: 'Ocular symptoms in children treated with human-mouse chimeric anti-GD2 mAb ch14.18 for neuroblastoma.'?,"No, this sentence does not indirectly support the statement that Dinutuximab treats neuroblastoma. The sentence only mentions that ocular symptoms were observed in children treated with human-mouse chimeric anti-GD2 mAb ch14.18 for neuroblastoma. It does not confirm nor deny whether this treatment is effective against neuroblastoma, nor does it mention Dinutuximab specifically. Dinutuximab is one type of anti-GD2 monoclonal antibody, but there are others, such as ch14.18, as mentioned in the sentence." -22808973,BRENTUXIMAB VEDOTIN treats anaplastic large cell lymphoma,1384,[Brentuximab vedotin for previously untreated systemic anaplastic large cell lymphoma].,True,Is the triple 'BRENTUXIMAB VEDOTIN treats anaplastic large cell lymphoma' supported by the sentence: '[Brentuximab vedotin for previously untreated systemic anaplastic large cell lymphoma].'?,"Yes, this statement is indirectly supported by the sentence provided. The sentence mentions that Brentuximab vedotin is used for previously untreated systemic anaplastic large cell lymphoma, which implies that it is a treatment option for this type of lymphoma." -22284390,BRENTUXIMAB VEDOTIN treats neoplasm,1385,"Although brentuximab-vedotin (BV) demonstrated single-agent activity, tumours regrew during BV therapy.",False,"Is the triple 'BRENTUXIMAB VEDOTIN treats neoplasm' supported by the sentence: 'Although brentuximab-vedotin (BV) demonstrated single-agent activity, tumours regrew during BV therapy.'?","No, this statement does not indirectly support the claim that Brentuximab Vedotin treats neoplasm (a type of cancer). In fact, it suggests the opposite. The sentence states that although BV showed initial activity, tumors regrew during BV therapy, implying that the treatment is not permanently effective for neoplasm." -21657991,BRENTUXIMAB VEDOTIN treats mature T-cell and NK-cell non-Hodgkin lymphoma,1386,BV is a major therapeutic advance in the treatment of patients with R/R CTCL and of those with PTCL in both the R/R and frontline settings.,True,Is the triple 'BRENTUXIMAB VEDOTIN treats mature T-cell and NK-cell non-Hodgkin lymphoma' supported by the sentence: 'BV is a major therapeutic advance in the treatment of patients with R/R CTCL and of those with PTCL in both the R/R and frontline settings.'?,"Yes, this statement can indirectly support the claim that Brentuximab Vedotin (BV) treats mature T-cell and NK-cell non-Hodgkin lymphoma (NHL). The sentence mentions BV as a significant advancement in treating patients with R/R Cutaneous T-cell Lymphoma (CTCL) and peripheral T-cell lymphoma (PTCL) in both relapsed/refractory (R/R) and frontline settings. CTCL and PTCL fall under mature T-cell NHL, so it suggests BV is an effective treatment for these subtypes, thus indirectly supporting the claim. However, it does not explicitly mention NK-cell NHL, so there is no direct support for this part of the claim from this sentence alone." -21657990,BRENTUXIMAB VEDOTIN treats primary cutaneous T-cell non-Hodgkin lymphoma,1387,BV is a major therapeutic advance in the treatment of patients with R/R CTCL and of those with PTCL in both the R/R and frontline settings.,True,Is the triple 'BRENTUXIMAB VEDOTIN treats primary cutaneous T-cell non-Hodgkin lymphoma' supported by the sentence: 'BV is a major therapeutic advance in the treatment of patients with R/R CTCL and of those with PTCL in both the R/R and frontline settings.'?,"Yes, the statement does provide indirect support for the claim. The abbreviation BV stands for Brentuximab Vedotin, which is mentioned as a major therapeutic advance in the treatment of patients with R/R CTCL (Refractory/Relapsed Cutaneous T-Cell Lymphoma) and PTCL (Peripheral T-Cell Lymphoma) in both the relapsed/refractory and frontline settings. Primary cutaneous T-cell non-Hodgkin lymphoma (PCTCL) falls under CTCL, so it can be inferred that Brentuximab Vedotin is also used to treat PCTCL, even though it is not explicitly stated in the sentence." -21596847,BRENTUXIMAB VEDOTIN treats Sezary syndrome,1388,"[Ulceration of lymphomatous skin lesions in a patient with Sezary syndrome treated with brentuximab-vedotin].BACKGROUND: Brentuximab-vedotin (BV), an anti-CD30 agent combined with an anti-neoplastic agent, has recently yielded promising results in the treatment of cutaneous T-lymphomas such as Sezary syndrome.",True,"Is the triple 'BRENTUXIMAB VEDOTIN treats Sezary syndrome' supported by the sentence: '[Ulceration of lymphomatous skin lesions in a patient with Sezary syndrome treated with brentuximab-vedotin].BACKGROUND: Brentuximab-vedotin (BV), an anti-CD30 agent combined with an anti-neoplastic agent, has recently yielded promising results in the treatment of cutaneous T-lymphomas such as Sezary syndrome.'?","Yes, this statement is indirectly supported by the sentence provided. The sentence mentions that Brentuximab-vedotin (BV) has shown promising results in treating cutaneous T-lymphomas, which includes Sezary syndrome. However, it does not explicitly state that BV treats Sezary syndrome, nor does it mention ulceration of lymphomatous skin lesions. Therefore, while it supports the efficacy of BV in treating Sezary syndrome, it does not directly support the specific claim about ulceration of lymphomatous skin lesions." -21569598,BRENTUXIMAB VEDOTIN treats adult T-cell leukemia/lymphoma,1389,Further investigations on the use of brentuximab vedotin for adult T-cell leukemia/lymphoma are needed.,False,Is the triple 'BRENTUXIMAB VEDOTIN treats adult T-cell leukemia/lymphoma' supported by the sentence: 'Further investigations on the use of brentuximab vedotin for adult T-cell leukemia/lymphoma are needed.'?,"No, this statement does not directly support the claim that brentuximab vedotin treats adult T-cell leukemia/lymphoma. The sentence suggests further research is needed, implying that the treatment is not yet proven or established." -21569593,BRENTUXIMAB VEDOTIN treats lymphoma,1390,Brentuximab vedotin represents a major breakthrough in the treatment of CD30-positive lymphomas.,True,Is the triple 'BRENTUXIMAB VEDOTIN treats lymphoma' supported by the sentence: 'Brentuximab vedotin represents a major breakthrough in the treatment of CD30-positive lymphomas.'?,"Yes, this statement does indirectly support the claim that Brentuximab vedotin treats lymphoma, as it refers to Brentuximab vedotin as a major breakthrough in treating CD30-positive lymphomas, which implies its therapeutic effect on lymphoma." -21525451,BRENTUXIMAB VEDOTIN treats Hodgkins lymphoma,1391,"Currently, ADCs that have received regulatory approval include brentuximab vedotin for CD30-positive Hodgkin lymphoma and trastuzumab emtansine for human epidermal growth factor receptor 2-positive breast cancer.",True,"Is the triple 'BRENTUXIMAB VEDOTIN treats Hodgkins lymphoma' supported by the sentence: 'Currently, ADCs that have received regulatory approval include brentuximab vedotin for CD30-positive Hodgkin lymphoma and trastuzumab emtansine for human epidermal growth factor receptor 2-positive breast cancer.'?","Yes, the statement is indirectly supported by the provided sentence. Brentuximab vedotin is approved for use in CD30-positive Hodgkin lymphoma, which implies its effectiveness in treating this type of cancer. However, the sentence does not explicitly state that Brentuximab vedotin is used to treat Hodgkin lymphoma, hence it is indirectly supported." -21472937,BRENTUXIMAB VEDOTIN treats mycosis fungoides,1392,The interest of BV in the management of CD30-positive mycosis fungoides (MF) and primary cutaneous anaplastic large cell lymphoma has recently been demonstrated compared to methotrexate or bexarotene.,True,Is the triple 'BRENTUXIMAB VEDOTIN treats mycosis fungoides' supported by the sentence: 'The interest of BV in the management of CD30-positive mycosis fungoides (MF) and primary cutaneous anaplastic large cell lymphoma has recently been demonstrated compared to methotrexate or bexarotene.'?,"Yes, this statement does indirectly support the claim that Brentuximab Vedotin (BV) can treat mycosis fungoides (MF). The sentence mentions the interest in using BV for CD30-positive MF, which is a specific form of mycosis fungoides. It also compares BV to methotrexate and bexarotene, which are commonly used treatments for various types of cancer, including MF. Therefore, it suggests that BV is an effective treatment option for MF, thus supporting the claim." -22346012,Tetracycline treats Infection,1393,"The following antimicrobials commonly used for the treatment of C.difficile infections or applied previously in C.difficile epidemiological studies were tested: metronidazole, vancomycin, meropenem, ceftriaxone, ampicillin-sulbactam, clindamycin, erythromycin, moxifloxacin, tetracycline, doxycycline, tigecycline and linezolid.",True,"Is the triple 'Tetracycline treats Infection' supported by the sentence: 'The following antimicrobials commonly used for the treatment of C.difficile infections or applied previously in C.difficile epidemiological studies were tested: metronidazole, vancomycin, meropenem, ceftriaxone, ampicillin-sulbactam, clindamycin, erythromycin, moxifloxacin, tetracycline, doxycycline, tigecycline and linezolid.'?","Yes, it is indirectly supported because tetracycline is listed as one of the antimicrobials tested, which suggests it is used for treating infections, specifically C.difficile infections, as mentioned in your sentence. However, it is important to note that the sentence does not explicitly state that tetracycline is used to treat infections, hence it is indirect support." -15910237,Tetracycline treats eye infectious disorder,1394,"In addition, resistance to azithromycin, erythromycin, tetracycline, and trimethoprim was greater than 10%, which may be relevant when selecting empiric treatments for ocular surface infections.",True,"Is the triple 'Tetracycline treats eye infectious disorder' supported by the sentence: 'In addition, resistance to azithromycin, erythromycin, tetracycline, and trimethoprim was greater than 10%, which may be relevant when selecting empiric treatments for ocular surface infections.'?","Yes, this statement does indirectly support the claim that Tetracycline can treat eye infections, as it mentions resistance to Tetracycline in relation to ocular surface infections. This suggests that Tetracycline is used, or at least considered, for treating such infections, even though it doesn't explicitly state so. The resistance to Tetracycline being greater than 10% also indicates its relevance in empiric treatments for ocular surface infections, further supporting its use in this context." -10596737,Tetracycline treats osteomyelitis,1395,[Clinical considerations on the topical use of a new hydrosoluble tetracycline derivative in chronic osteomyelitis].,True,Is the triple 'Tetracycline treats osteomyelitis' supported by the sentence: '[Clinical considerations on the topical use of a new hydrosoluble tetracycline derivative in chronic osteomyelitis].'?,"Yes, this statement is indirectly supported by the sentence provided, as it mentions the use of a new hydrosoluble tetracycline derivative in chronic osteomyelitis, implying that tetracyclines can be used to treat this condition, such as Tetracycline. However, it is essential to acknowledge that more specific information would be required to confirm this directly, like clinical trials, studies, or other scientific evidence directly involving Tetracycline for treating osteomyelitis." -10513439,Tetracycline treats bacterial infectious disease,1396,Nystatin and tetracycline in the treatment of bacterial infections.,True,Is the triple 'Tetracycline treats bacterial infectious disease' supported by the sentence: 'Nystatin and tetracycline in the treatment of bacterial infections.'?,"Yes, it is indirectly supported. The sentence ""Nystatin and tetracycline in the treatment of bacterial infections"" implies that both Nystatin and Tetracycline can be used to treat bacterial infections, which aligns with the statement ""Tetracycline treats bacterial infectious disease"". However, it does not directly state that Tetracycline is used to treat bacterial infections on its own, hence it is indirect support." -10332719,Tetracycline treats periodontitis,1397,Meta-analysis of local tetracycline in treating chronic periodontitis.,True,Is the triple 'Tetracycline treats periodontitis' supported by the sentence: 'Meta-analysis of local tetracycline in treating chronic periodontitis.'?,"Yes, this sentence does indirectly support the statement that Tetracycline treats periodontitis. The meta-analysis mentioned in the sentence is studying the effects of local Tetracycline on chronic periodontitis, which implies that Tetracycline is being used as a treatment for this condition. Therefore, it provides evidence that Tetracycline is used in treating periodontitis, even if it doesn't directly prove that Tetracycline is effective in this role." -7227539,Tetracycline treats Helicobacter pylori infectious disease,1398,"Ranitidine bismuth citrate, tetracycline, clarithromycin twice-a-day triple therapy for clarithromycin susceptible Helicobacter pylori infection.",True,"Is the triple 'Tetracycline treats Helicobacter pylori infectious disease' supported by the sentence: 'Ranitidine bismuth citrate, tetracycline, clarithromycin twice-a-day triple therapy for clarithromycin susceptible Helicobacter pylori infection.'?","Yes, this statement does indirectly support the claim that Tetracycline can treat Helicobacter pylori infectious disease. The sentence suggests that Tetracycline is used in a triple therapy (alongside Ranitidine bismuth citrate and clarithromycin) to treat clarithromycin susceptible Helicobacter pylori infection. Therefore, it implies that Tetracycline has some efficacy against this type of infection, even if it is not acting alone in this treatment regimen." -22788639,(Alginate)n treats Pain,1399,"With these results, we propose alginate-based nanoemulsions as a potential treatment for migraine pain.",True,"Is the triple '(Alginate)n treats Pain' supported by the sentence: 'With these results, we propose alginate-based nanoemulsions as a potential treatment for migraine pain.'?","Yes, the triple quote ""Alginate treats pain"" is indirectly supported by the sentence ""With these results, we propose alginate-based nanoemulsions as a potential treatment for migraine pain."" This is because alginate is mentioned as part of the proposed treatment for migraine pain, which implies that it has some role in alleviating pain associated with migraines. However, it is important to note that alginate itself is not directly treating pain, but rather is part of a proposed treatment method for migraines, which may alleviate pain as a secondary effect." -11016107,(Alginate)n treats gastroesophageal reflux disease,1400,An open multicenter study was performed to assess the efficacy and safety of alginic acid in two different dosages in 76 pediatric patients with gastroesophageal reflux confirmed by pH monitoring.,True,Is the triple '(Alginate)n treats gastroesophageal reflux disease' supported by the sentence: 'An open multicenter study was performed to assess the efficacy and safety of alginic acid in two different dosages in 76 pediatric patients with gastroesophageal reflux confirmed by pH monitoring.'?,"Yes, this statement does provide indirect evidence for the treatment of gastroesophageal reflux disease (GERD) by alginic acid, also known as alginate, in children. The study, though it does not directly prove the effectiveness of alginate in treating GERD, does show its safety and efficacy in managing symptoms in pediatric patients with GERD as confirmed by pH monitoring. However, further research, including randomized controlled trials, would be needed to establish alginic acid as a definitive treatment for GERD in children." -22283339,Chlorhexidine treats Peri-Implantitis,1401,There is a need for more homogenous RCTs with large sample size to define the role of CHX in non-surgical management of peri-implant mucositis and peri-implantitis.,False,Is the triple 'Chlorhexidine treats Peri-Implantitis' supported by the sentence: 'There is a need for more homogenous RCTs with large sample size to define the role of CHX in non-surgical management of peri-implant mucositis and peri-implantitis.'?,"No, this sentence does not indirectly support the statement that Chlorhexidine (CHX) treats peri-implantitis. The sentence is discussing the need for more research, specifically randomized controlled trials (RCTs) with larger sample sizes, to define CHX's role in managing peri-implant mucositis and peri-implantitis. This suggests that the current evidence is insufficient or inconsistent, which does not support the claim that CHX treats peri-implantitis." -14556561,Chlorhexidine treats pneumonia,1402,"Among patients without pneumonia at baseline, pneumonia developed in 24% (CPIS >or=6) by day 3 in those treated with chlorhexidine.",False,"Is the triple 'Chlorhexidine treats pneumonia' supported by the sentence: 'Among patients without pneumonia at baseline, pneumonia developed in 24% (CPIS >or=6) by day 3 in those treated with chlorhexidine.'?","No, this statement does not indirectly support the claim that Chlorhexidine treats pneumonia. The sentence you provided is from a study where chlorhexidine was used for mouthwash in mechanically ventilated patients to prevent ventilator-associated pneumonia (VAP). The study found that among patients who did not have pneumonia at baseline, 24% developed pneumonia by day 3 in those treated with chlorhexidine. This suggests that chlorhexidine may not be effective in preventing pneumonia in this population, rather it might delay its onset, but it does not support the claim that chlorhexidine treats established pneumonia." -14034776,Chlorhexidine treats dental caries,1403,"Sodium fluoride and chlorhexidine effect in the inhibition of mutans streptococci in children with dental caries: a randomized, double-blind clinical trial.",True,"Is the triple 'Chlorhexidine treats dental caries' supported by the sentence: 'Sodium fluoride and chlorhexidine effect in the inhibition of mutans streptococci in children with dental caries: a randomized, double-blind clinical trial.'?","Yes, this statement is indirectly supported by this sentence because Chlorhexidine is mentioned as one of the agents being tested in this clinical trial, which aims to inhibit mutans streptococci in children with dental caries, an indirect reference to treating dental caries. Sodium fluoride is also mentioned, which is another agent used to treat dental caries, further supporting this claim." -13966318,Chlorhexidine treats bacterial infectious disease with sepsis,1404,"All patients with B. stabilis bacteraemia had indwelling intravenous catheters, which were treated with chlorhexidine to disinfect the catheters.",False,"Is the triple 'Chlorhexidine treats bacterial infectious disease with sepsis' supported by the sentence: 'All patients with B. stabilis bacteraemia had indwelling intravenous catheters, which were treated with chlorhexidine to disinfect the catheters.'?","No, this statement does not provide indirect support for the claim that chlorhexidine treats bacterial infections causing sepsis. The sentence only mentions that chlorhexidine is used to disinfect indwelling intravenous catheters in patients with B. stabilis bacteraemia, which is a type of bloodstream infection, but it does not confirm that chlorhexidine is used to treat bacterial infections causing sepsis specifically, nor does it indicate the effectiveness of chlorhexidine in treating these infections." -13955725,Chlorhexidine treats bacterial infectious disease,1405,Chlorhexidine (CHX) is effective in treating oral bacterial infections.,True,Is the triple 'Chlorhexidine treats bacterial infectious disease' supported by the sentence: 'Chlorhexidine (CHX) is effective in treating oral bacterial infections.'?,"Yes, this statement does provide indirect support for the claim that Chlorhexidine can treat bacterial infections. The sentence specifically mentions Chlorhexidine (CHX) and states it is effective in treating oral bacterial infections, which implies it has antibacterial properties, thus supporting its role in treating bacterial diseases, though not directly implying it can treat all types of bacterial infections beyond oral ones." -13614413,Chlorhexidine treats stomatitis,1406,CONCLUSIONS: The frequency and duration of OM are significantly improved by prophylactic chlorhexidine and by cryotherapy.,True,Is the triple 'Chlorhexidine treats stomatitis' supported by the sentence: 'CONCLUSIONS: The frequency and duration of OM are significantly improved by prophylactic chlorhexidine and by cryotherapy.'?,"Yes, this sentence does indirectly support the statement ""Chlorhexixine treats stomatitis."" Stomatitis is an inflammation of the mouth, also known as oral mucositis (OM). The conclusion states that both prophylactic chlorhexidine (a mouthwash containing chlorhexidine) and cryotherapy (a treatment to reduce inflammation) significantly improve the frequency and duration of OM, which implies chlorhexidine is an effective treatment for mouth inflammation (stomatitis)." -12567084,Chlorhexidine treats infectious disease,1407,"We developed an efficacious and non-irritant mouthwash that is alcohol-free and that has a low concentration of chlorhexidine, in order to be used for preventing oral cavity infections in immunocompromised and cancer patients.",True,"Is the triple 'Chlorhexidine treats infectious disease' supported by the sentence: 'We developed an efficacious and non-irritant mouthwash that is alcohol-free and that has a low concentration of chlorhexidine, in order to be used for preventing oral cavity infections in immunocompromised and cancer patients.'?","Yes, the sentence does indirectly support the statement that Chlorhexidine treats infectious diseases. The sentence mentions an efficacious mouthwash being developed with a low concentration of Chlorhexidine for preventing oral cavity infections in immunocompromised and cancer patients. This implies that Chlorhexidine is an effective substance in treating oral cavity infections, which are types of infectious diseases." -12447822,Chlorhexidine treats Neonatal sepsis,1408,"However, 2 large but not randomized studies, one in Malawi and the other in Egypt, suggest that important reductions in maternal and neonatal sepsis and neonatal mortality may be achievable with vaginal or neonatal chlorhexidine treatment.",True,"Is the triple 'Chlorhexidine treats Neonatal sepsis' supported by the sentence: 'However, 2 large but not randomized studies, one in Malawi and the other in Egypt, suggest that important reductions in maternal and neonatal sepsis and neonatal mortality may be achievable with vaginal or neonatal chlorhexidine treatment.'?","Yes, this statement does indirectly support the claim that chlorhexidine can treat neonatal sepsis, as it suggests reductions in neonatal sepsis through chlorhexidine treatment, which implies potential therapeutic benefits for neonates suffering from this condition. However, it should be noted that this evidence is derived from two observational studies, not randomized controlled trials (RCTs), which could limit its generalizability and certainty." -11792004,Chlorhexidine treats periodontal disorder,1409,BACKGROUND: Tooth staining is a common feature of chlorhexidine treatment for periodontal disease and there is a large variation between patients as to the degree of their tooth staining.,True,Is the triple 'Chlorhexidine treats periodontal disorder' supported by the sentence: 'BACKGROUND: Tooth staining is a common feature of chlorhexidine treatment for periodontal disease and there is a large variation between patients as to the degree of their tooth staining.'?,"Yes, this statement indirectly supports the idea that Chlorhexidine treats periodontal disease, as it mentions chlorhexidine being used for treatment, even though it highlights tooth staining as a side effect. The presence of side effects is evidence for its use in treatment, even if indirectly, as it suggests patients have undergone chlorhexidine treatment for their periodontal disease, experiencing tooth staining as an adverse reaction to this treatment." -10593306,Chlorhexidine treats eye infectious disorder,1410,Clinical trial of chlorhexidine and diaminodiphenylsulphone in superficial ocular infections.,True,Is the triple 'Chlorhexidine treats eye infectious disorder' supported by the sentence: 'Clinical trial of chlorhexidine and diaminodiphenylsulphone in superficial ocular infections.'?,"Yes, this statement can be seen as indirectly supporting the claim that chlorhexidine can treat eye infections, as it mentions a clinical trial involving chlorhexidine in treating ocular infections, which implies some level of efficacy for this application. However, it should be noted that this is based on one trial, so more research would be needed to solidify this conclusion." -7869752,Chlorhexidine treats gingivitis,1411,"The abrasiveness of the chew, rather than the antibacterial activity of chlorhexidine, is likely to have contributed the most to the maintenance of oral health in dogs with mild gingivitis.",False,"Is the triple 'Chlorhexidine treats gingivitis' supported by the sentence: 'The abrasiveness of the chew, rather than the antibacterial activity of chlorhexidine, is likely to have contributed the most to the maintenance of oral health in dogs with mild gingivitis.'?","No, this statement does not indirectly support the claim that Chlorhexidine treats gingivitis in dogs. The sentence provided emphasizes the abrasiveness of the chew as contributing to oral health in dogs, not Chlorhexidine, which is an antiseptic used to prevent infection, not directly treat gingivitis, especially when it is not mentioned as an active ingredient in any chew product in this context." -7287519,Chlorhexidine treats periodontitis,1412,Assessing the effectiveness of locally delivered chlorhexidine in the treatment of periodontitis.,True,Is the triple 'Chlorhexidine treats periodontitis' supported by the sentence: 'Assessing the effectiveness of locally delivered chlorhexidine in the treatment of periodontitis.'?,"Yes, this statement does provide indirect support for the claim that chlorhexidine can treat periodontitis. The sentence is assessing the effectiveness of locally delivered chlorhexidine in treating periodontitis, which implies that chlorhexidine is being considered as a potential treatment for this condition. However, it does not directly confirm that chlorhexidine can treat periodontitis, hence it is indirect support." -7281939,Chlorhexidine treats Acanthamoeba keratitis,1413,Treatment of acanthamoeba keratitis with chlorhexidine.,True,Is the triple 'Chlorhexidine treats Acanthamoeba keratitis' supported by the sentence: 'Treatment of acanthamoeba keratitis with chlorhexidine.'?,"Yes, the statement ""Treatment of acanthamoeba keratitis with chlorhexidine"" does indirectly support the claim that ""Chlorhexidine treats Acanthamoeba keratitis"". This is because treatment generally implies the use of a substance to alleviate or cure a condition, which in this case is Acanthamoeba keratitis, and chlorhexidine is the substance being used for this purpose. However, it is important to note that indirect support does not equate to definitive proof, and further research would be needed to establish a direct causal relationship between chlorhexidine use and successful treatment of Acanthamoeba keratitis." -22179313,Nicergoline treats depressive disorder,1414,"The Efficacy of Sertraline, Escitalopram, and Nicergoline in the Treatment of Depression and Apathy in Alzheimer's Disease: The Okayama Depression and Apathy Project (ODAP).BACKGROUND: Neuropsychiatric symptoms of dementia such as depression and apathy in patients with Alzheimer's disease (AD) are associated with a lower quality of life.",False,"Is the triple 'Nicergoline treats depressive disorder' supported by the sentence: 'The Efficacy of Sertraline, Escitalopram, and Nicergoline in the Treatment of Depression and Apathy in Alzheimer's Disease: The Okayama Depression and Apathy Project (ODAP).BACKGROUND: Neuropsychiatric symptoms of dementia such as depression and apathy in patients with Alzheimer's disease (AD) are associated with a lower quality of life.'?","No, this statement does not indirectly support that Nicergoline treats depressive disorder in Alzheimer's patients. The sentence only mentions Nicergoline as one of the treatments used in a study for depression and apathy in Alzheimer's disease, but it does not provide any information about its efficacy in treating depression specifically." -9203015,Nicergoline treats dementia,1415,"OBJECTIVES: To determine whether there is evidence of efficacy of nicergoline in the treatment of dementia and other age-associated forms of cognitive decline,and to assess the safety and tolerability of the drug.",True,"Is the triple 'Nicergoline treats dementia' supported by the sentence: 'OBJECTIVES: To determine whether there is evidence of efficacy of nicergoline in the treatment of dementia and other age-associated forms of cognitive decline,and to assess the safety and tolerability of the drug.'?","Yes, the sentence does indirectly support the statement that Nicergoline treats dementia. The objectives mentioned in the sentence include determining whether there is evidence of efficacy of nicergoline in the treatment of dementia, which suggests that nicergoline is being studied for its potential therapeutic effects on dementia. This does not confirm that nicergoline definitely treats dementia, but it does indicate a potential link, which is what makes the statement indirectly supported." -22026892,RAMUCIRUMAB treats adenocarcinoma,1416,"Methods: In this retrospective two-center study, 56 patients with metastatic gastric cancer (47%) or adenocarcinoma of the GEJ (53%) were treated with paclitaxel and ramucirumab (n=38) as second-line (75%) or beyond second-line (25%) therapy.",True,"Is the triple 'RAMUCIRUMAB treats adenocarcinoma' supported by the sentence: 'Methods: In this retrospective two-center study, 56 patients with metastatic gastric cancer (47%) or adenocarcinoma of the GEJ (53%) were treated with paclitaxel and ramucirumab (n=38) as second-line (75%) or beyond second-line (25%) therapy.'?","Yes, this statement does indirectly support the claim that Ramucirumab treats adenocarcinoma. The sentence states that patients with gastric cancer or adenocarcinoma of the GEJ (gastroesophageal junction) were treated with Ramucirumab, which suggests that Ramucirumab is used as a treatment for these types of cancers, including adenocarcinoma. However, it doesn't directly state that Ramucirumab treats adenocarcinoma, hence the indirect support." -21622108,RAMUCIRUMAB treats non-small cell lung carcinoma,1417,This study aimed to validate the primary prophylactic use of pegfilgrastim with docetaxel and ramucirumab treatment in Japanese patients with NSCLC.,True,Is the triple 'RAMUCIRUMAB treats non-small cell lung carcinoma' supported by the sentence: 'This study aimed to validate the primary prophylactic use of pegfilgrastim with docetaxel and ramucirumab treatment in Japanese patients with NSCLC.'?,"Yes, this statement does indirectly support the claim that Ramucirumab treats non-small cell lung carcinoma (NSCLC). The sentence states that the study aimed to validate the use of Ramucirumab treatment in Japanese patients with NSCLC, implying that Ramucirumab is used as a treatment option for this type of lung cancer." -21474987,RAMUCIRUMAB treats hepatocellular carcinoma,1418,Cost-effectiveness analysis of ramucirumab treatment for patients with hepatocellular carcinoma who progressed on sorafenib with alpha-fetoprotein concentrations of at least 400 ng/ml.,False,Is the triple 'RAMUCIRUMAB treats hepatocellular carcinoma' supported by the sentence: 'Cost-effectiveness analysis of ramucirumab treatment for patients with hepatocellular carcinoma who progressed on sorafenib with alpha-fetoprotein concentrations of at least 400 ng/ml.'?,"No, this sentence does not indirectly support the statement that Ramucirumab treats hepatocellular carcinoma. The sentence only mentions the cost-effectiveness analysis of ramucirumab treatment for patients with hepatocellular carcinoma who progressed on sorafenib with alpha-fetoprotein concentrations of at least 400 ng/ml. It does not indicate that ramucirumab is effective in treating hepatocellular carcinoma." -23342893,TAFASITAMAB treats diffuse large B-cell lymphoma,1419,Lenalidomide was recently approved in combination with the anti-monoclonal B-cell antibody tafasitamab for patients with relapsed DLBCL after 1 to 3 previous treatments.,True,Is the triple 'TAFASITAMAB treats diffuse large B-cell lymphoma' supported by the sentence: 'Lenalidomide was recently approved in combination with the anti-monoclonal B-cell antibody tafasitamab for patients with relapsed DLBCL after 1 to 3 previous treatments.'?,"Yes, the statement is indirectly supported. The sentence mentions that lenalidomide, when combined with tafasitamab, was approved for treating relapsed diffuse large B-cell lymphoma (DLBCL) in patients who have had 1 to 3 previous treatments. This implies that tafasitamab, in combination with lenalidomide, is effective in treating DLBCL, thus providing indirect support for the claim that tafasitamab treats DLBCL." -22828138,Thioctic acid treats cystinuria,1420,Tolvaptan and a-Lipoic acid were also tested in patients with cystinuria and resulted in reduction of recurrence.,True,Is the triple 'Thioctic acid treats cystinuria' supported by the sentence: 'Tolvaptan and a-Lipoic acid were also tested in patients with cystinuria and resulted in reduction of recurrence.'?,"Yes, there is indirect support for this statement based on the sentence provided. Thioctic Acid is also known as Alpha-Lipoic Acid, which is mentioned in the sentence as one of the substances tested in patients with cystinuria, resulting in reduced recurrence. Therefore, it can be inferred that Thioctic Acid (Alpha-Lipoic Acid) may have a role in treating or managing cystinuria, at least based on this indirect evidence." -21111424,Thioctic acid treats optic neuritis,1421,"Conclusion: Six weeks of oral lipoic acid supplementation after acute optic neuritis is safe and well tolerated; however, because of insufficient recruitment, we could not conclude that lipoic acid treatment was neuroprotective in acute optic neuritis.",False,"Is the triple 'Thioctic acid treats optic neuritis' supported by the sentence: 'Conclusion: Six weeks of oral lipoic acid supplementation after acute optic neuritis is safe and well tolerated; however, because of insufficient recruitment, we could not conclude that lipoic acid treatment was neuroprotective in acute optic neuritis.'?","No, this statement does not indirectly support the claim that thioctic acid, also known as alpha-lipoic acid, treats optic neuritis. The conclusion from this study suggests that oral lipoic acid supplementation after acute optic neuritis is safe and well-tolerated, but due to insufficient recruitment, they could not conclude if lipoic acid treatment was neuroprotective in acute optic neuritis. The claim that thioctic/lipoic acid treats optic neuritis would require stronger evidence, such as direct improvement in patients diagnosed with this condition, which is not provided in this statement." -14414806,Thioctic acid treats carpal tunnel syndrome,1422,Treatment of carpal tunnel syndrome with alpha-lipoic acid.,True,Is the triple 'Thioctic acid treats carpal tunnel syndrome' supported by the sentence: 'Treatment of carpal tunnel syndrome with alpha-lipoic acid.'?,"Yes, this statement is indirectly supported because Thioctic Acid is another name for Alpha-Lipoic Acid. Therefore, if Alpha-Lipoic Acid is used to treat Carpal Tunnel Syndrome, then it follows that Thioctic Acid would also be effective for this purpose, given their chemical equivalence." -11271151,Thioctic acid treats skin disorder,1423,Alpha-Lipoic acid-based PPARgamma agonists for treating inflammatory skin diseases.,True,Is the triple 'Thioctic acid treats skin disorder' supported by the sentence: 'Alpha-Lipoic acid-based PPARgamma agonists for treating inflammatory skin diseases.'?,"Yes, this statement is indirectly supported by the sentence provided. Thioctic acid is another name for alpha-lipoic acid, which is known to act as a PPARgamma agonist. PPARgamma agonists have been suggested for treating inflammatory skin diseases, therefore, thioctic acid could potentially have similar effects, although direct evidence supporting this specific claim is not provided in the sentence." -9864403,Thioctic acid treats multiple sclerosis,1424,"For study of antioxidant therapy efficiency in relapsing-remitting multiple sclerosis we investigated group 1 (18 patients) treated with alpha-lipoic acid and group 2 (14 patients) who received complex of antioxidants and neuroprotectors with various mechanisms of action (oc-lipoic acid, Nicotinamide, Acetylcysteine, Triovit Beta-carotine, Alpha-tocopheryl acetate, Ascorbic acid, Selenium, Pentoxifylline, Cerebrolysin, Amantadine hydrochloride) during 1 month, 2 times a year.",False,"Is the triple 'Thioctic acid treats multiple sclerosis' supported by the sentence: 'For study of antioxidant therapy efficiency in relapsing-remitting multiple sclerosis we investigated group 1 (18 patients) treated with alpha-lipoic acid and group 2 (14 patients) who received complex of antioxidants and neuroprotectors with various mechanisms of action (oc-lipoic acid, Nicotinamide, Acetylcysteine, Triovit Beta-carotine, Alpha-tocopheryl acetate, Ascorbic acid, Selenium, Pentoxifylline, Cerebrolysin, Amantadine hydrochloride) during 1 month, 2 times a year.'?","No, this sentence does not provide direct evidence to support the claim that Thioctic Acid (also known as alpha-lipoic acid) treats Multiple Sclerosis (MS). The sentence only mentions that alpha-lipoic acid was used in a study involving patients with relapsing-remitting MS, but it does not mention any therapeutic effects or benefits. Furthermore, alpha-lipoic acid was used in combination with other substances, making it difficult to attribute any potential effects specifically to alpha-lipoic acid." -8933101,Thioctic acid treats Alzheimer disease,1425,"Despite the fact that this study was small and not randomized, this is the first indication that treatment with alpha-lipoic acid might be a successful 'neuroprotective' therapy option for AD and related dementias.",False,"Is the triple 'Thioctic acid treats Alzheimer disease' supported by the sentence: 'Despite the fact that this study was small and not randomized, this is the first indication that treatment with alpha-lipoic acid might be a successful 'neuroprotective' therapy option for AD and related dementias.'?","No, this sentence does not directly support the statement that thioctic acid, also known as alpha-lipoic acid, treats Alzheimer's disease (AD). The sentence only suggests that alpha-lipoic acid might be a successful neuroprotective therapy option for AD and related dementias, based on a small, non-randomized study. It does not confirm that it is a treatment for AD." -8739967,Thioctic acid treats hypertensive disorder,1426,"STZ-diabetes resulted in increased blood pressure, which was partially improved by alpha-lipoic acid treatment.",True,"Is the triple 'Thioctic acid treats hypertensive disorder' supported by the sentence: 'STZ-diabetes resulted in increased blood pressure, which was partially improved by alpha-lipoic acid treatment.'?","Yes, this statement can be interpreted as indirect support for the idea that thioctic acid (also known as alpha-lipoic acid) can help improve hypertension, which is a component of hypertensive disorders. The statement suggests that in a study using streptozotocin-induced diabetes (STZ-diabetes), increased blood pressure was observed, and this was partially improved by treatment with alpha-lipoic acid. However, it's important to note that this is an indirect inference, as the study was conducted in a specific model (STZ-diabetes), not in humans diagnosed with hypertensive disorders. Therefore, more research would be needed to directly support the claim that thioctic acid can treat hypertensive disorders in humans." -7865558,Thioctic acid treats type 2 diabetes mellitus,1427,"AIMS: Thioctic acid (TA), glibenclamide and acarbose are widely used to either alone or concomitantly treat patients suffering from noninsulin-dependent diabetes (NIDDM).",True,"Is the triple 'Thioctic acid treats type 2 diabetes mellitus' supported by the sentence: 'AIMS: Thioctic acid (TA), glibenclamide and acarbose are widely used to either alone or concomitantly treat patients suffering from noninsulin-dependent diabetes (NIDDM).'?","Yes, this statement does indirectly support the claim that thioctic acid can be used to treat type 2 diabetes mellitus (which is another name for NIDDM). The sentence explicitly states that thioctic acid is used in the treatment of noninsulin-dependent diabetes, which is another term for type 2 diabetes. However, it does not directly state that thioctic acid treats this condition, hence the term 'indirectly'." -7603474,Thioctic acid treats diabetic neuropathy,1428,"A two-central randomised single-blind placebo-controlled study was conducted to assess efficacy of intravenous administration of trometamol salt of thioctic (alpha-lipoic) acid (Thioctacid 600, ""ASTA Medica"", Germany) in 200 ml of physiological solution in 40 non-insulin dependent diabetic patients with symptomatic diabetic neuropathy.",True,"Is the triple 'Thioctic acid treats diabetic neuropathy' supported by the sentence: 'A two-central randomised single-blind placebo-controlled study was conducted to assess efficacy of intravenous administration of trometamol salt of thioctic (alpha-lipoic) acid (Thioctacid 600, ""ASTA Medica"", Germany) in 200 ml of physiological solution in 40 non-insulin dependent diabetic patients with symptomatic diabetic neuropathy.'?","Yes, this sentence does provide indirect support for the statement that Thioctic acid treats diabetic neuropathy. The sentence describes a clinical study involving 40 non-insulin dependent diabetic patients who were given intravenous administration of Thioctic (alpha-lipoic) acid to assess its efficacy in treating symptomatic diabetic neuropathy, which is a complication related to diabetes. The fact that such a study was conducted implies that there is some scientific basis for believing Thioctic acid may have therapeutic benefits for this condition, even though this particular sentence does not explicitly state such an outcome." -21616335,Ampicillin treats Infection,1429,"Penicillin Allergy in Pregnancy: Moving From ""Rash"" Decisions to Accurate Diagnosis.The emergence of beta-lactam-resistant pathogenic organisms has resulted in limitation or even elimination of drugs such as penicillin and ampicillin from available antibiotic choices for treating common infections in obstetrics and gynecology.",False,"Is the triple 'Ampicillin treats Infection' supported by the sentence: 'Penicillin Allergy in Pregnancy: Moving From ""Rash"" Decisions to Accurate Diagnosis.The emergence of beta-lactam-resistant pathogenic organisms has resulted in limitation or even elimination of drugs such as penicillin and ampicillin from available antibiotic choices for treating common infections in obstetrics and gynecology.'?","No, the triple ""Ampicillin treats Infection"" is not indirectly supported by this sentence. The sentence mentions Ampicillin as one of the antibiotics whose use is limited due to emergence of beta-lactam-resistant pathogens, but it does not make any explicit claim about Ampicillin being used to treat infections in general, hence it does not support the claim indirectly." -16205290,Ampicillin treats chorioamnionitis,1430,"The patient was treated with pressors and antibiotics and was admitted to the medical intensive care unit where she received ampicillin, gentamycin, and clindamycin for suspected chorioamnionitis.",True,"Is the triple 'Ampicillin treats chorioamnionitis' supported by the sentence: 'The patient was treated with pressors and antibiotics and was admitted to the medical intensive care unit where she received ampicillin, gentamycin, and clindamycin for suspected chorioamnionitis.'?","Yes, this statement does indirectly support the claim that ampicillin is used to treat chorioamnionitis. The patient in question was administered ampicillin among other antibiotics for suspected chorioamnionitis, which suggests that ampicillin is one of the medications used to treat this condition. However, it should be noted that the statement does not directly confirm that ampicillin is used specifically to treat chorioamnionitis, but rather it is used in the treatment regimen for this condition." -15830384,Ampicillin treats bacterial infectious disease,1431,Based on these results aztreonam appears to be at least as effective as and possibly more effective than amikacin when used initially with ampicillin for empiric treatment of neonatal bacterial infections.,True,Is the triple 'Ampicillin treats bacterial infectious disease' supported by the sentence: 'Based on these results aztreonam appears to be at least as effective as and possibly more effective than amikacin when used initially with ampicillin for empiric treatment of neonatal bacterial infections.'?,"Yes, this statement does indirectly support the claim that ampicillin is used to treat bacterial infections, as it mentions ampicillin being used in empiric treatment for neonatal bacterial infections. However, it doesn't directly support the effectiveness comparison between ampicillin, aztreonam, and amikacin mentioned in the first statement, as it only compares aztreonam to amikacin when used with ampicillin, not directly to ampicillin itself." -14976711,Ampicillin treats osteomyelitis,1432,"When antibiotic therapy was delayed for seven days, osteomyelitis developed in four of eight animals treated locally with microencapsulated ampicillin and in six of eight animals that received parenteral ampicillin therapy.",False,"Is the triple 'Ampicillin treats osteomyelitis' supported by the sentence: 'When antibiotic therapy was delayed for seven days, osteomyelitis developed in four of eight animals treated locally with microencapsulated ampicillin and in six of eight animals that received parenteral ampicillin therapy.'?","No, this statement does not directly support the claim that Ampicillin treats osteomyelitis. However, it does suggest that Ampicillin, when administered locally or parenterally, can potentially prevent or treat osteomyelitis, as fewer animals developed the condition when treated with Ampicillin compared to those without treatment. However, this is an indirect inference, as the primary focus of the sentence is on the timing of antibiotic therapy rather than the drug's effectiveness in treating osteomyelitis." -12551965,Ampicillin treats Sepsis,1433,"In the present study, we validated the antagonism in combinations of VCM with other beta-lactams, i.e., flomoxef (FMOX), ampicillin (AMPC), azthreonam (AZT) and imipenem/cilastatin (IPM/CS), in systemic infections and pneumoniain in mice.",True,"Is the triple 'Ampicillin treats Sepsis' supported by the sentence: 'In the present study, we validated the antagonism in combinations of VCM with other beta-lactams, i.e., flomoxef (FMOX), ampicillin (AMPC), azthreonam (AZT) and imipenem/cilastatin (IPM/CS), in systemic infections and pneumoniain in mice.'?","Yes, this statement does provide indirect support for the claim that ampicillin can treat sepsis, as it mentions ampicillin (AMPC) as one of the beta-lactams tested in combination with vancomycin (VCM) for systemic infections, which includes sepsis, in mice. However, it is essential to note that this statement does not explicitly state that ampicillin alone can treat sepsis, nor does it provide any data on ampicillin's effectiveness in treating sepsis specifically." -9906170,Ampicillin treats bacterial meningitis,1434,"The mortality rate in this type of BM is still high among those treated with ampicillin or penicillin, and a decrease in the mortality rate was not observed when the reported cases in Spain in the last 30 years were analyzed.",False,"Is the triple 'Ampicillin treats bacterial meningitis' supported by the sentence: 'The mortality rate in this type of BM is still high among those treated with ampicillin or penicillin, and a decrease in the mortality rate was not observed when the reported cases in Spain in the last 30 years were analyzed.'?","No, this statement does not support the claim that ampicillin treats bacterial meningitis (BM). In fact, it suggests the contrary. If the mortality rate remains high among those treated with ampicillin, it implies that ampicillin is not effectively treating BM. Therefore, it is not supported that ampicillin is a treatment for BM, at least not based on this statement alone." -8394714,Ampicillin treats gonorrhea,1435,Ampicillin has assumed a prominent role in the treatment of gonorrhoea.,True,Is the triple 'Ampicillin treats gonorrhea' supported by the sentence: 'Ampicillin has assumed a prominent role in the treatment of gonorrhoea.'?,"Yes, indirectly supported. The second sentence states that Ampicillin has an important role in treating gonorrhoea, which implies that it is indeed used to treat this disease, as in the first sentence. However, it does not explicitly state that Ampicillin is used to treat all cases of gonorrhoea, nor does it mention anything about it curing the disease, which is what the first sentence implies." -7166712,Ampicillin treats pneumonia,1436,[Clinical efficacy of sulbactam/ampicillin in comparison with cefotiam in the treatment of elderly patients with pneumonia].,False,Is the triple 'Ampicillin treats pneumonia' supported by the sentence: '[Clinical efficacy of sulbactam/ampicillin in comparison with cefotiam in the treatment of elderly patients with pneumonia].'?,"No, this statement does not indirectly support the claim that Ampicillin treats pneumonia. The statement discusses the clinical efficacy of sulbactam/ampicillin compared to cefotiam in treating elderly patients with pneumonia, but it does not confirm that Ampicillin alone is effective in treating pneumonia." -22520021,Carbenicillin treats bacterial infectious disease,1437,In this study results of treatment with ceftazidime were superior to results of treatment with amikacin/carbenicillin for invasive bacterial infections of newborn infants.,True,Is the triple 'Carbenicillin treats bacterial infectious disease' supported by the sentence: 'In this study results of treatment with ceftazidime were superior to results of treatment with amikacin/carbenicillin for invasive bacterial infections of newborn infants.'?,"Yes, this statement does indirectly support the claim that Carbenicillin is used to treat bacterial infections, specifically in newborn infants when used in combination with amikacin. The sentence mentions ceftazidime as having superior results, but it does not negate the effectiveness of Carbenicillin in treating bacterial infections." -26119472,Bacampicillin treats bacterial infectious disease,1438,Clinical trial of bacampicillin in acute bacterial infections.,True,Is the triple 'Bacampicillin treats bacterial infectious disease' supported by the sentence: 'Clinical trial of bacampicillin in acute bacterial infections.'?,"Yes, this statement is indirectly supported by the sentence provided. The clinical trial mentioned in the sentence suggests that bacampicillin is being tested for its effectiveness in treating acute bacterial infections, which implies that bacampicillin is used to treat bacterial infections, thus aligning with the claim in the triple statement. However, it should be noted that this does not directly prove that bacampicillin specifically treats bacterial infections, as it could be used for other purposes in the trial, such as prevention, symptom relief, etc." -25659721,Aspoxicillin treats bacterial infectious disease,1439,The above results suggest that ASPC is an useful antibiotic for treating pediatric bacterial infections.,True,Is the triple 'Aspoxicillin treats bacterial infectious disease' supported by the sentence: 'The above results suggest that ASPC is an useful antibiotic for treating pediatric bacterial infections.'?,"Yes, this statement is indirectly supported because it mentions ASPC, which is short for Aspoxicillin, as an effective antibiotic for treating pediatric bacterial infections, implying it can be used to treat certain types of bacterial infections, which is in line with the original statement." -13845936,Mezlocillin treats bacterial infectious disease,1440,"An open, multicentre study was performed in hospital in-patients at a total of 12 German hospitals to investigate the efficacy and tolerability of sulbactam combined with mezlocillin, piperacillin or cefotaxime in severe bacterial infections.",True,"Is the triple 'Mezlocillin treats bacterial infectious disease' supported by the sentence: 'An open, multicentre study was performed in hospital in-patients at a total of 12 German hospitals to investigate the efficacy and tolerability of sulbactam combined with mezlocillin, piperacillin or cefotaxime in severe bacterial infections.'?","Yes, this statement does indirectly support the claim that Mezlocillin is used to treat bacterial infections, as it mentions an open study investigating its efficacy in severe bacterial infections, which implies its use as a treatment." -7407212,Benzoyl Peroxide treats acne,1441,"Treatments for acne can be topical or systemic, and include retinoids, antibiotics, benzoyl peroxide, azelaic acid, and hormonal therapy.",True,"Is the triple 'Benzoyl Peroxide treats acne' supported by the sentence: 'Treatments for acne can be topical or systemic, and include retinoids, antibiotics, benzoyl peroxide, azelaic acid, and hormonal therapy.'?","Yes, the statement is indirectly supported. The sentence provided lists several treatments for acne, including benzoyl peroxide, which suggests its use in treating acne. However, it does not explicitly state that benzoyl peroxide is used to treat acne, hence it is indirectly supported." -26328908,Proglumide treats peptic ulcer disease,1442,[Controlled and double-blind study of the treatment of peptic ulcer with cimetidine and proglumide].,True,Is the triple 'Proglumide treats peptic ulcer disease' supported by the sentence: '[Controlled and double-blind study of the treatment of peptic ulcer with cimetidine and proglumide].'?,"Yes, this statement is indirectly supported by the given sentence. The sentence mentions a controlled and double-blind study of the treatment of peptic ulcer with cimetidine and proglumide, which suggests that proglumide is being used in the treatment of peptic ulcer disease, thus providing indirect support for the claim. However, it does not directly state that proglumide treats peptic ulcer disease, as it mentions the study alongside cimetidine, another drug used for treating this condition." -13022426,Pirenzepine treats gastroesophageal reflux disease,1443,Pirenzepine may provide a unique alternative for some GERD patients who may be refractory to other therapies of GERD.,True,Is the triple 'Pirenzepine treats gastroesophageal reflux disease' supported by the sentence: 'Pirenzepine may provide a unique alternative for some GERD patients who may be refractory to other therapies of GERD.'?,"Yes, this is indirectly supported by the sentence provided. The sentence suggests that Pirenzepine may be beneficial for some patients with Gastroesophageal Reflux Disease (GERD) who do not respond to other treatments, implying that Pirenzepine does treat GERD, at least for some patients who are refractory to other therapies." -10839963,Pirenzepine treats peptic ulcer disease,1444,Four hundred and two patients with peptic ulcer were selected for acute therapy with either pirenzepine (100 mg/day) or cimetidine (800 mg/day) using the envelope method.,True,Is the triple 'Pirenzepine treats peptic ulcer disease' supported by the sentence: 'Four hundred and two patients with peptic ulcer were selected for acute therapy with either pirenzepine (100 mg/day) or cimetidine (800 mg/day) using the envelope method.'?,"Yes, this sentence does indirectly support the statement that Pirenzepine treats peptic ulcer disease. The sentence mentions a study where patients with peptic ulcers were given Pirenzepine, implying that it was used as a treatment for the disease. However, it does not directly state that Pirenzepine is effective in treating peptic ulcers, which is why it is only indirectly supportive." -16332442,Magnesium Oxide treats autosomal recessive inherited pseudoxanthoma elasticum,1445,"In that context, magnesium oxide significantly reduced CIMT in PXE mice, and may be useful for disease prevention in PXE patients.",True,"Is the triple 'Magnesium Oxide treats autosomal recessive inherited pseudoxanthoma elasticum' supported by the sentence: 'In that context, magnesium oxide significantly reduced CIMT in PXE mice, and may be useful for disease prevention in PXE patients.'?","Yes, this statement can be interpreted as indirectly supporting the idea that Magnesium Oxide may be useful in treating Autosomal Recessive Inherited Pseudoxanthoma Elasticum (PXE). The sentence mentions that Magnesium Oxide significantly reduced CIMT (Carotid Intima-Media Thickness) in PXE mice, which suggests it could have beneficial effects on PXE symptoms. However, it does not explicitly state that Magnesium Oxide treats PXE, but rather suggests it may be useful for disease prevention, which aligns with treating symptoms rather than being a direct cure for PXE." -15225864,Magnesium Oxide treats constipation disorder,1446,"This report presents the rare case of a 75-year-old woman who developed a rectal obstruction caused by a pharmacobezoar, following the long-term ingestion of magnesium oxide cathartics for constipation.",True,"Is the triple 'Magnesium Oxide treats constipation disorder' supported by the sentence: 'This report presents the rare case of a 75-year-old woman who developed a rectal obstruction caused by a pharmacobezoar, following the long-term ingestion of magnesium oxide cathartics for constipation.'?","Yes, this statement does provide indirect support for the claim that Magnesium Oxide can treat constipation disorder. The report mentions a case where a woman experienced rectal obstruction due to long-term ingestion of magnesium oxide cathartics, which are used for treating constipation. This suggests that magnesium oxide does have an effect on the gastrointestinal system, which could include treating constipation, although it should be noted that in this case, long-term use led to complications." -26045826,Ticarcillin treats Sepsis,1447,Mezlocillin and ticarcillin in the treatment of patients with serious systemic infections.,True,Is the triple 'Ticarcillin treats Sepsis' supported by the sentence: 'Mezlocillin and ticarcillin in the treatment of patients with serious systemic infections.'?,"Yes, this statement does indirectly support the claim that Ticarcillin can be used to treat sepsis, which is a serious systemic infection. However, it does not directly mention sepsis, so it is an indirect form of evidence based on the context provided." -9410149,Ticarcillin treats osteomyelitis,1448,Obviously unbalanced comparative studies showed some benefit of ticarcillin for bone infections caused by Pseudomonas species.,False,Is the triple 'Ticarcillin treats osteomyelitis' supported by the sentence: 'Obviously unbalanced comparative studies showed some benefit of ticarcillin for bone infections caused by Pseudomonas species.'?,"No, this statement does not indirectly support that Ticarcillin treats osteomyelitis. The sentence provided indicates that ticarcillin may have some benefit for bone infections caused by Pseudomonas species, but it does not specify osteomyelitis, which is a specific type of bone infection caused by various bacteria, not only Pseudomonas species. Therefore, it does not provide sufficient evidence to claim that Ticarcillin is used to treat osteomyelitis." -26823243,Urea treats citrullinemia,1449,"The precursors of urea (ammonia, glutamate, glutamine and alpha-amino nitrogen) did not increase after the benzoate administration in the 6 normal subjects as well as in the 2 patients with citrullinaemia.",False,"Is the triple 'Urea treats citrullinemia' supported by the sentence: 'The precursors of urea (ammonia, glutamate, glutamine and alpha-amino nitrogen) did not increase after the benzoate administration in the 6 normal subjects as well as in the 2 patients with citrullinaemia.'?","No, this sentence does not indirectly support the statement that urea treats citrullinemia. The sentence mentions that benzoate administration does not increase precursors of urea in both normal subjects and patients with citrullinaemia, which does not provide evidence for urea as a treatment for citrullinemia. Citrullinemia is a disorder characterized by an accumulation of citrulline due to a deficiency in the enzyme arginosuccinate synthetase, not necessarily due to issues with urea production directly." -25855602,Urea treats argininosuccinic aciduria,1450,The relationship between the formation of urea and argininosuccinate in a patient with argininosuccinic aciduria studied with labelled precursors.,True,Is the triple 'Urea treats argininosuccinic aciduria' supported by the sentence: 'The relationship between the formation of urea and argininosuccinate in a patient with argininosuccinic aciduria studied with labelled precursors.'?,"Yes, this sentence does indirectly support the statement that urea can treat argininosuccinic aciduria (ASA). The sentence mentions the study of a patient with ASA using labelled precursors, which likely refers to substances used to synthesize other compounds in metabolic pathways, such as urea cycle intermediates. The fact that such a study was conducted suggests an interest in understanding how urea metabolism is affected in ASA patients, possibly indicating an attempt to explore urea as a potential treatment for ASA, as it can help remove excess ammonia from the body, which is one of the main issues in ASA patients. However, it is important to note that this sentence does not explicitly confirm urea as a treatment for ASA, so further research is needed to establish its efficacy in treating this disorder." -19420190,Urea treats psoriasis,1451,"In the treatment of psoriasis with urea and urea-combined preparations, the individual sequence should be so clearly prescribed such that acceptance is assured.",True,"Is the triple 'Urea treats psoriasis' supported by the sentence: 'In the treatment of psoriasis with urea and urea-combined preparations, the individual sequence should be so clearly prescribed such that acceptance is assured.'?","Yes, this statement can be seen as supporting the claim that urea treats psoriasis, albeit indirectly. The sentence suggests that urea, when used in the treatment of psoriasis, should be prescribed in a particular sequence to ensure acceptance, implying that urea is an effective treatment when used correctly. However, it does not directly state that urea is the sole cause of improved symptoms, as other factors such as the prescribed sequence could also play a role." -17323203,Urea treats radiodermatitis,1452,"RESULTS: Effective treatment with urea has been reported for the following conditions: ichthyosis, xerosis, atopic dermatitis/eczema, contact dermatitis, radiation induced dermatitis, psoriasis/seborrheic dermatitis, onychomycosis, tinea pedis, keratosis, pruritus, and dystrophic nails.",True,"Is the triple 'Urea treats radiodermatitis' supported by the sentence: 'RESULTS: Effective treatment with urea has been reported for the following conditions: ichthyosis, xerosis, atopic dermatitis/eczema, contact dermatitis, radiation induced dermatitis, psoriasis/seborrheic dermatitis, onychomycosis, tinea pedis, keratosis, pruritus, and dystrophic nails.'?","Yes, the statement is indirectly supported because radiation-induced dermatitis is one of the conditions listed in the sentence provided, and urea is reported as an effective treatment for it, which includes treating symptoms associated with radiodermatitis, thus providing indirect support for the statement ""Urea treats radiodermatitis""." -15413374,Urea treats hepatocellular carcinoma,1453,"INTRODUCTION: Sorafenib is a novel oral bis-aryl urea compound that has proven survival benefit in patients with advanced hepatocellular carcinoma (HCC), for which several therapies are currently available with unsatisfactory results.",True,"Is the triple 'Urea treats hepatocellular carcinoma' supported by the sentence: 'INTRODUCTION: Sorafenib is a novel oral bis-aryl urea compound that has proven survival benefit in patients with advanced hepatocellular carcinoma (HCC), for which several therapies are currently available with unsatisfactory results.'?","Yes, this statement does provide indirect support for the idea that urea can treat hepatocellular carcinoma (HCC). The sentence mentions that Sorafenib, which is a bis-aryl urea compound, has proven survival benefit in patients with advanced HCC. This suggests that urea-based compounds can have therapeutic effects on HCC, even though Sorafenib itself is not urea but a compound containing urea molecules. However, it's important to note that this is an indirect inference and further research would be needed to confirm any direct effects of urea on HCC." -12068406,Urea treats type 2 diabetes mellitus,1454,These findings are consistent with the inhibition of hepatic glycogenolysis and support the use of acyl ureas for the treatment of type 2 diabetes.,True,Is the triple 'Urea treats type 2 diabetes mellitus' supported by the sentence: 'These findings are consistent with the inhibition of hepatic glycogenolysis and support the use of acyl ureas for the treatment of type 2 diabetes.'?,"Yes, this statement can be interpreted as indirectly supporting the idea that urea can treat type 2 diabetes mellitus, as it suggests acyl ureas (a class of compounds which includes ureas) can inhibit hepatic glycogenolysis, which is a characteristic feature of type 2 diabetes management. However, it is important to note that this does not directly imply urea itself is an effective treatment, as acyl ureas may have different properties and mechanisms of action compared to urea itself. Further research would be needed to confirm this hypothesis." -11649881,Urea treats Pain,1455,"Novel transient receptor potential vanilloid 1 receptor antagonists for the treatment of pain: structure-activity relationships for ureas with quinoline, isoquinoline, quinazoline, phthalazine, quinoxaline, and cinnoline moieties.",True,"Is the triple 'Urea treats Pain' supported by the sentence: 'Novel transient receptor potential vanilloid 1 receptor antagonists for the treatment of pain: structure-activity relationships for ureas with quinoline, isoquinoline, quinazoline, phthalazine, quinoxaline, and cinnoline moieties.'?","Yes, the sentence does provide indirect support for the claim that urea can treat pain, as it discusses novel transient receptor potential vanilloid 1 (TRPV1) receptor antagonists for pain treatment, which include ureas in their structure. TRPV1 receptors play an important role in pain sensation, inflammation, and neurogenic inflammation, making them potential targets for pain management. However, it does not directly prove that urea itself is responsible for pain relief, as it could be due to other components in these ureas or their specific structural features interacting with TRPV1 receptors." -10679439,Urea treats skin disorder,1456,[TROPHIC ACTION OF UREA AND ITS USE IN THE TREATMENT OF NEUROTROPHIC SKIN DISEASES].,True,Is the triple 'Urea treats skin disorder' supported by the sentence: '[TROPHIC ACTION OF UREA AND ITS USE IN THE TREATMENT OF NEUROTROPHIC SKIN DISEASES].'?,"Yes, the statement is indirectly supported by this sentence. The phrase ""[TROPHIC ACTION OF UREA AND ITS USE IN THE TREATMENT OF NEUROTROPHIC SKIN DISEASES]"" suggests that urea has therapeutic effects on certain types of skin disorders, which could be related to neurotrophic diseases, as indicated in the title. However, it does not explicitly state that urea is used to treat general skin disorders, nor does it mention urea treating uremic pruritus specifically, which is often considered a skin disorder related to uremia, not urea itself." -10511987,Urea treats diabetes mellitus,1457,"[Preliminary note on the oral treatment of diabetes by N-sulfonyl-p-methylbenzene-N'-n-butyl urea or D 860, a product free of antibacterial action].",False,"Is the triple 'Urea treats diabetes mellitus' supported by the sentence: '[Preliminary note on the oral treatment of diabetes by N-sulfonyl-p-methylbenzene-N'-n-butyl urea or D 860, a product free of antibacterial action].'?","No, this statement does not indirectly support the claim that urea treats diabetes mellitus. The sentence mentions N-sulfonyl-p-methylbenzene-N'-n-butyl urea, also known as D 860, which is distinct from urea. Therefore, there is no connection established between urea and the treatment of diabetes mellitus in this context." -8678587,"Urea treats dermatitis, atopic",1458,"In the present report, we compared two creams, identical with the exception that one contained both urea and sodium chloride and the other urea alone, in 22 patients with atopic dermatitis.",True,"Is the triple 'Urea treats dermatitis, atopic' supported by the sentence: 'In the present report, we compared two creams, identical with the exception that one contained both urea and sodium chloride and the other urea alone, in 22 patients with atopic dermatitis.'?","Yes, this sentence does indirectly support the statement that urea treats dermatitis, atopic. The sentence mentions a study where two creams were compared, one containing urea and sodium chloride, and the other containing urea alone, in patients with atopic dermatitis. The fact that such a study was conducted suggests that there is some basis for believing that urea could be beneficial in treating atopic dermatitis. However, it does not directly prove that urea alone is effective, as the study compared creams containing both urea and sodium chloride to those containing urea alone. Therefore, while it supports the idea that urea could be useful in treating atopic dermatitis, it does not definitively prove it." -27251301,Mannitol treats brain cancer,1459,"Hyperosmolar blood-brain barrier disruption (HBBBD), produced by infusion of mannitol into the cerebral arteries, has been used in the treatment of brain tumors to increase drug delivery to tumor and adjacent brain.",True,"Is the triple 'Mannitol treats brain cancer' supported by the sentence: 'Hyperosmolar blood-brain barrier disruption (HBBBD), produced by infusion of mannitol into the cerebral arteries, has been used in the treatment of brain tumors to increase drug delivery to tumor and adjacent brain.'?","Yes, this is supported, although indirectly, because mannitol is used to disrupt the blood-brain barrier, which allows for increased drug delivery to tumors in the brain, potentially treating brain cancer as a result." -21059003,Mannitol treats hearing loss disorder,1460,[Effects of mannitol on the fluids of the internal ear. Use in the treatment of deafness].,True,Is the triple 'Mannitol treats hearing loss disorder' supported by the sentence: '[Effects of mannitol on the fluids of the internal ear. Use in the treatment of deafness].'?,"Yes, this sentence does provide some support for the idea that Mannitol may be used in treating deafness, which is a type of hearing loss. The sentence mentions both the effects of Mannitol on the fluids of the internal ear, which is where damage to these fluids can lead to deafness, and its use in the treatment of deafness. However, it does not explicitly state that Mannitol treats hearing loss disorders, so the support is somewhat indirect." -20425957,Mannitol treats osteoarthritis,1461,Objective: To assess efficacy and safety of a single intra-articular injection of 2% sodium hyaluronate plus 0.5% mannitol in patients with symptomatic osteoarthritis of the knee.,True,Is the triple 'Mannitol treats osteoarthritis' supported by the sentence: 'Objective: To assess efficacy and safety of a single intra-articular injection of 2% sodium hyaluronate plus 0.5% mannitol in patients with symptomatic osteoarthritis of the knee.'?,"Yes, this sentence does provide indirect support for the statement that Mannitol treats osteoarthritis, at least in combination with sodium hyaluronate. The sentence mentions a study to assess the efficacy and safety of a single intra-articular injection of 2% sodium hyaluronate plus 0.5% mannitol in patients with symptomatic osteoarthritis of the knee. This implies that mannitol is being used as a treatment for osteoarthritis, although it is not being used alone, but in combination with sodium hyaluronate." -16945033,Mannitol treats hypotensive disorder,1462,"These values were correlated with expected risk factors for lactatemia including length of surgery, Body Mass Index (BMI), hypotension, hemoglobin and mannitol therapy.",True,"Is the triple 'Mannitol treats hypotensive disorder' supported by the sentence: 'These values were correlated with expected risk factors for lactatemia including length of surgery, Body Mass Index (BMI), hypotension, hemoglobin and mannitol therapy.'?","Yes, this statement does indirectly support the claim that Mannitol treats hypotensive disorder. The sentence mentions Mannitol therapy in correlation with hypotension, implying its use as a treatment for this condition. However, it does not explicitly state that Mannitol is used to treat hypotension, hence it is indirectly supported." -12644644,Mannitol treats Pain,1463,"Further treatments with intravenous mannitol, oral carbonic anhydrase inhibitor, topical antiglaumatic agents and subconjunctival 5-fluorouracil (5-FU) injections all failed to control relapsing pain and IOP elevation.",False,"Is the triple 'Mannitol treats Pain' supported by the sentence: 'Further treatments with intravenous mannitol, oral carbonic anhydrase inhibitor, topical antiglaumatic agents and subconjunctival 5-fluorouracil (5-FU) injections all failed to control relapsing pain and IOP elevation.'?","No, the sentence does not support the claim that Mannitol treats pain. In fact, it states that mannitol, when used intravenously, failed to control relapsing pain and intraocular pressure (IOP) elevation. This suggests that mannitol might not be effective in treating pain, contrary to the claim." -11774217,Mannitol treats brain injury,1464,CONCLUSIONS: The results suggested that mannitol could improve cerebral perfusion in patients with mild brain damage.,True,Is the triple 'Mannitol treats brain injury' supported by the sentence: 'CONCLUSIONS: The results suggested that mannitol could improve cerebral perfusion in patients with mild brain damage.'?,"Yes, this statement can be interpreted as providing indirect support for the idea that mannitol may help treat brain injuries, as improved cerebral perfusion can be beneficial in managing such conditions. However, it should be noted that this is an inference based on a general conclusion, and specific clinical studies would be needed to directly support mannitol as a treatment for brain injuries." -11660589,Mannitol treats malaria,1465,"A possibly indulgent wish list of outcome (mortality) studies using currently known treatment modalities, however, includes the loading dose of quinine, vigorous fluid replacement, ET, the artemisinins, mannitol, and N-acetylcysteine in the treatment of severe malaria.",True,"Is the triple 'Mannitol treats malaria' supported by the sentence: 'A possibly indulgent wish list of outcome (mortality) studies using currently known treatment modalities, however, includes the loading dose of quinine, vigorous fluid replacement, ET, the artemisinins, mannitol, and N-acetylcysteine in the treatment of severe malaria.'?","Yes, the statement ""Mannitol treats malaria"" is indirectly supported by the sentence provided, which states, ""A possibly indulgent wish list of outcome (mortality) studies using currently known treatment modalities, however, includes... mannitol, in the treatment of severe malaria."" This indicates that mannitol is being considered for use in treating severe malaria, thus providing an indirect support for the statement. However, it is important to note that this does not necessarily mean that mannitol is an established treatment for malaria, but rather it is being considered for further study in this context." -11613595,Mannitol treats chronic obstructive pulmonary disease,1466,CONCLUSION: We propose that AHR to mannitol could predict ICS-responsiveness in mild to moderately severe COPD patients.,True,Is the triple 'Mannitol treats chronic obstructive pulmonary disease' supported by the sentence: 'CONCLUSION: We propose that AHR to mannitol could predict ICS-responsiveness in mild to moderately severe COPD patients.'?,"Yes, this sentence does provide indirect support for the statement that mannitol can treat COPD. The sentence in question is discussing research into how mannitol can affect airway hyperresponsiveness (AHR) in COPD patients, which is a key characteristic of COPD. The researchers suggest that AHR to mannitol could predict ICS-responsiveness, implying that mannitol has an impact on COPD symptoms, thus providing support for its use as a treatment for COPD, at least in terms of its potential to predict response to other treatments (ICS). However, it is important to note that this is based on indirect evidence, as it does not directly show mannitol improving COPD symptoms, but rather suggests it could be used as a marker for potential treatment response in patients." -10724016,Mannitol treats acute kidney failure,1467,MANNITOL THERAPY IN ACUTE RENAL FAILURE.,True,Is the triple 'Mannitol treats acute kidney failure' supported by the sentence: 'MANNITOL THERAPY IN ACUTE RENAL FAILURE.'?,"Yes, the statement ""Mannitol treats acute kidney failure"" is indirectly supported by the sentence ""MANNITOL THERAPY IN ACUTE RENAL FAILURE."" This is because the term 'therapy' in the given sentence suggests the use of Mannitol in treating, or managing, Acute Renal Failure, which aligns with the first statement, albeit in a more indirect manner." -10707564,Mannitol treats injury,1468,Mannitol has a beneficial effect on ischemic injury following a short-duration forebrain ischemic insult in rats.,True,Is the triple 'Mannitol treats injury' supported by the sentence: 'Mannitol has a beneficial effect on ischemic injury following a short-duration forebrain ischemic insult in rats.'?,"Yes, this statement is indirectly supported by the provided sentence from the research study involving rats, as it indicates that mannitol has beneficial effects on ischemic (reduced blood flow) injuries in the forebrain region. The user-provided sentence mentions mannitol treating injuries, which is in line with this research finding, where mannitol has a positive impact on reducing damage caused by ischemic insults, thus providing some level of support for its role in treating injuries, albeit in this specific context of ischemic injuries in rats." -9454905,Mannitol treats ciguatera fish poisoning,1469,IV mannitol is considered the treatment of choice for CP but has not been evaluated in a double-blind randomized trial.,False,Is the triple 'Mannitol treats ciguatera fish poisoning' supported by the sentence: 'IV mannitol is considered the treatment of choice for CP but has not been evaluated in a double-blind randomized trial.'?,"No, this statement does not indirectly support the claim that Mannitol treats ciguatera fish poisoning (CP). The statement mentions IV mannitol as a treatment for CP, but it does not specify its effectiveness in treating CP, nor does it mention anything about mannitol being used to treat symptoms related to mannitol intake, which is what would be needed to indirectly support the original claim." -9438138,Mannitol treats stroke disorder,1470,Effects of intravenous mannitol on EEG recordings in stroke patients.,True,Is the triple 'Mannitol treats stroke disorder' supported by the sentence: 'Effects of intravenous mannitol on EEG recordings in stroke patients.'?,"Yes, this statement can be interpreted as indirect support for the claim that mannitol treats stroke disorders, as it suggests mannitol has an effect on EEG recordings in stroke patients, implying its use in treating strokes. However, it does not directly state that mannitol is used to treat strokes, nor does it prove its effectiveness in treating strokes, so it is only indirect support for the claim." -8850005,Mannitol treats coronary artery disorder,1471,"The data suggest the need to further evaluate the physiological importance of the increase in coronary blood flow produced by mannitol in patients with coronary artery disease and indicate the possibility that mannitol might be of value in treating certain problems in patients with coronary artery disease,",True,"Is the triple 'Mannitol treats coronary artery disorder' supported by the sentence: 'The data suggest the need to further evaluate the physiological importance of the increase in coronary blood flow produced by mannitol in patients with coronary artery disease and indicate the possibility that mannitol might be of value in treating certain problems in patients with coronary artery disease,'?","Yes, this sentence does indirectly support the statement that Mannitol treats Coronary Artery Disorder. The sentence suggests further evaluation is needed on the increase in blood flow produced by Mannitol in patients with Coronary Artery Disease, indicating a potential value in treatment. This implies Mannitol could have a positive effect on Coronary Artery Disorder, which aligns with the statement that Mannitol treats it, albeit indirectly." -8674974,Mannitol treats bronchiectasis,1472,The 24-h effect of mannitol on the clearance of mucus in patients with bronchiectasis.,True,Is the triple 'Mannitol treats bronchiectasis' supported by the sentence: 'The 24-h effect of mannitol on the clearance of mucus in patients with bronchiectasis.'?,"Yes, this statement can be seen as indirectly supporting the claim that mannitol treats bronchiectasis, as it suggests mannitol has an effect on mucus clearance in patients with bronchiectasis, which is a symptom often associated with the condition. However, it does not directly state that mannitol is a treatment for bronchiectasis, so further evidence would be needed to confirm this." -8007841,"Mannitol treats chronic myelogenous leukemia, BCR-ABL1 positive",1473,Treatment of chronic myelocytic leukaemia with dibromo-mannitol (myelobromol).,False,"Is the triple 'Mannitol treats chronic myelogenous leukemia, BCR-ABL1 positive' supported by the sentence: 'Treatment of chronic myelocytic leukaemia with dibromo-mannitol (myelobromol).'?","No, this statement is not indirectly supported by the given sentence. The sentence mentions the treatment of chronic myelocytic leukaemia (CML) with dibromo-mannitol, also known as myelobromol, but it does not mention BCR-ABL1 positive as a specific type of CML being treated, nor does it mention mannitol as a treatment. Dibromo-mannitol and mannitol are not the same compound, as dibromo-mannitol has two bromine atoms attached to the mannitol molecule, significantly changing its chemical properties." -7780960,Mannitol treats cystic fibrosis,1474,Inhaled mannitol is a potential mucoactive agent in cystic fibrosis patients.,True,Is the triple 'Mannitol treats cystic fibrosis' supported by the sentence: 'Inhaled mannitol is a potential mucoactive agent in cystic fibrosis patients.'?,"Yes, this statement is indirectly supported because inhaled Mannitol is being suggested as a treatment for Cystic Fibrosis patients, which aligns with the first part of the sentence stating Mannitol as a treatment for Cystic Fibrosis. The term mucoactive agent refers to substances that can change mucus properties, which is relevant to treating Cystic Fibrosis as patients often experience thick mucus build-up in their lungs." -7352141,Mannitol treats intracranial hypertension,1475,"CONCLUSION: Hypertonic saline, in both 3 and 23.4% concentrations, is as effective as mannitol in the treatment of intracranial hypertension observed in association with ICH.",True,"Is the triple 'Mannitol treats intracranial hypertension' supported by the sentence: 'CONCLUSION: Hypertonic saline, in both 3 and 23.4% concentrations, is as effective as mannitol in the treatment of intracranial hypertension observed in association with ICH.'?","Yes, this sentence does provide indirect support for the statement that mannitol treats intracranial hypertension, as it mentions mannitol being used in the treatment of intracranial hypertension associated with ICH (Intracerebral Hemorrhage). However, it doesn't directly support the comparison with Mannitol treating intracranial hypertension better than hypertonic saline, as it only states they are equally effective." -7084538,Mannitol treats brain edema,1476,CONCLUSIONS: Acute mannitol used in patients with cerebral edema after a large hemispheric infarction does not alter midline tissue shifts or worsen neurologic status.,True,Is the triple 'Mannitol treats brain edema' supported by the sentence: 'CONCLUSIONS: Acute mannitol used in patients with cerebral edema after a large hemispheric infarction does not alter midline tissue shifts or worsen neurologic status.'?,"Yes, this is supported, but it is an indirect inference based on the information provided in this sentence. The sentence suggests that mannitol is used in patients who have cerebral edema after a large hemispheric infarction, which implies it is used to treat this condition, as stated in the triple statement provided in your question. However, it does not directly state mannitol treats brain edema, but rather implies it based on its use in patients who have cerebral edema." -23769437,Temocillin treats bacterial infectious disease with sepsis,1477,The objective is to investigate if temocillin is non-inferior to carbapenems in the targeted treatment of bacteraemia due to 3GCR-E.,True,Is the triple 'Temocillin treats bacterial infectious disease with sepsis' supported by the sentence: 'The objective is to investigate if temocillin is non-inferior to carbapenems in the targeted treatment of bacteraemia due to 3GCR-E.'?,"Yes, this statement does indirectly support the claim that Temocillin can treat bacterial infections, specifically bacteraemia due to 3GCR-E, which is a type of bacteria often associated with sepsis, a severe form of bacterial infection. The statement implies a clinical investigation into Temocillin's effectiveness compared to carbapenems, which are often used as last-resort antibiotics for severe infections, including sepsis. However, it does not explicitly state that Temocillin treats sepsis, but rather a specific type of bacteria known to cause it." -17734631,Artesunic acid treats hepatocellular carcinoma,1478,CONCLUSION: These findings indicate that artesunate could offer a new approach to the therapy of hepatocellular carcinoma.,True,Is the triple 'Artesunic acid treats hepatocellular carcinoma' supported by the sentence: 'CONCLUSION: These findings indicate that artesunate could offer a new approach to the therapy of hepatocellular carcinoma.'?,"Yes, this statement can be interpreted as indirectly supporting the idea that Artesunic acid treats hepatocellular carcinoma, given that it suggests artesunate (which is related to Artesunic acid) could be a new approach to treating hepatocellular carcinoma. However, it is important to note that this is an inference, as the sentence does not explicitly state that Artesunic acid is an effective treatment for this type of cancer." -16415826,Artesunic acid treats Crohn disease,1479,Our data suggest a novel clinical application of artesunate as a potential therapy for Crohn's disease.,True,Is the triple 'Artesunic acid treats Crohn disease' supported by the sentence: 'Our data suggest a novel clinical application of artesunate as a potential therapy for Crohn's disease.'?,"Yes, this sentence does indirectly support the statement that artesunic acid may be useful in treating Crohn's disease. The key phrase here is ""a novel clinical application of artesunate as a potential therapy for Crohn's disease."" Artesunate is a derivative of artemisinin, which is the active ingredient in artesunic acid. Therefore, if artesunate is suggested to be effective in treating Crohn's disease, it stands to reason that artesunic acid, being related, could also have therapeutic potential. However, it's important to note that this is an indirect inference, as the original sentence specifically mentions artesunate, not artesunic acid. Further research would be needed to confirm this hypothesis." -15681287,Artesunic acid treats breast neoplasm,1480,Taken together our in vitro and in vivo results correlate well showing for the first time that artesunate induces resistance in highly metastatic breast tumors.,False,Is the triple 'Artesunic acid treats breast neoplasm' supported by the sentence: 'Taken together our in vitro and in vivo results correlate well showing for the first time that artesunate induces resistance in highly metastatic breast tumors.'?,"No, this statement does not support the claim that Artesunic acid treats breast neoplasm (breast cancer). In fact, it suggests the opposite - that artesunate may induce resistance in highly metastatic breast tumors, which could potentially make treatment more difficult." -13704055,Artesunic acid treats cytomegalovirus infection,1481,"This is the first report of treatment of cytomegalovirus infection with artesunate, for a stem cell transplant recipient with a newly identified foscarnet-resistant and ganciclovir-resistant DNA polymerase L776M mutation.",True,"Is the triple 'Artesunic acid treats cytomegalovirus infection' supported by the sentence: 'This is the first report of treatment of cytomegalovirus infection with artesunate, for a stem cell transplant recipient with a newly identified foscarnet-resistant and ganciclovir-resistant DNA polymerase L776M mutation.'?","Yes, this sentence does indirectly support the statement that artesunic acid can treat cytomegalovirus infection, as it reports the first successful treatment of such an infection using artesunate in a specific case involving drug-resistant mutations. However, it should be noted that this is only one case, so more research would be needed to confirm this finding and understand its broader implications." -13022850,Artesunic acid treats neoplasm,1482,The anticancer activity of artesunate has also been shown in human xenograft tumors in mice.,True,Is the triple 'Artesunic acid treats neoplasm' supported by the sentence: 'The anticancer activity of artesunate has also been shown in human xenograft tumors in mice.'?,"Yes, this sentence does provide indirect support for the statement that artesunic acid has anticancer activity in humans, also known as treating neoplasms. The sentence mentions anticancer activity in human xenograft tumors in mice, which suggests that artesunate has anticancer effects in human cells, even if it was observed in an animal model (mice). However, it is important to note that further research is needed to confirm these effects in humans directly, as results from animal studies may not always translate to humans due to differences in biological systems." -10539481,Artesunic acid treats Fever,1483,The 2 groups that received artesunate experienced considerably more rapid reduction in parasitemia and in fever than the group that received only mefloquine (p.002).,True,Is the triple 'Artesunic acid treats Fever' supported by the sentence: 'The 2 groups that received artesunate experienced considerably more rapid reduction in parasitemia and in fever than the group that received only mefloquine (p.002).'?,"Yes, this statement does provide indirect support for the claim that artesunic acid can treat fever, as it suggests that artesunate (a derivative of artesunic acid) has an effect on reducing fever more rapidly than mefloquine. However, it does not directly mention artesunic acid, so it is an indirect form of evidence." -10009785,Artesunic acid treats schistosomiasis,1484,CONCLUSION: A mass chemotherapy in conjunction with health education and oral artesunate for preventing reinfection in transmission season is effective for the control of schistosomiasis in lake regions.,True,Is the triple 'Artesunic acid treats schistosomiasis' supported by the sentence: 'CONCLUSION: A mass chemotherapy in conjunction with health education and oral artesunate for preventing reinfection in transmission season is effective for the control of schistosomiasis in lake regions.'?,"Yes, this statement does provide indirect support for the claim that artesunic acid is effective in treating schistosomiasis. The sentence states that mass chemotherapy (which would include artesunic acid, as it is an oral medication) in conjunction with health education and oral artesunate (a form of artesunic acid) is effective for controlling schistosomiasis in lake regions. This implies that artesunic acid has some role in treating or preventing this disease, thus providing indirect support for the claim." -9194607,Artesunic acid treats urinary schistosomiasis,1485,"Artesunate and praziquantel for the treatment of Schistosoma haematobium infections: a double-blind, randomized, placebo-controlled study.",True,"Is the triple 'Artesunic acid treats urinary schistosomiasis' supported by the sentence: 'Artesunate and praziquantel for the treatment of Schistosoma haematobium infections: a double-blind, randomized, placebo-controlled study.'?","Yes, the statement is indirectly supported. The sentence provided discusses a study using Artesunate, which is related to Artesunic Acid as they both contain artemisinin, a potent antimalarial and anti-schistosome compound. Artesunate, when used in combination with Praziquantel, has been shown to improve treatment outcomes for Schistosoma haematobium infections, which is a form of urinary schistosomiasis. Therefore, this study provides evidence supporting the use of compounds related to Artesunic Acid in treating urinary schistosomiasis, even though it does not explicitly mention Artesunic Acid itself." -7990355,Artesunic acid treats Plasmodium vivax malaria,1486,"To define the current efficacy of Fansidar (F. Hoffmann-La Roche Ltd., Basel Switzerland) (pyrimethamine and sulfadoxine), primaquine in a high dose, and artesunate for treating acute Plasmodium vivax malaria, we conducted a comparative clinical trial of these 3 drugs in an open-label study.",True,"Is the triple 'Artesunic acid treats Plasmodium vivax malaria' supported by the sentence: 'To define the current efficacy of Fansidar (F. Hoffmann-La Roche Ltd., Basel Switzerland) (pyrimethamine and sulfadoxine), primaquine in a high dose, and artesunate for treating acute Plasmodium vivax malaria, we conducted a comparative clinical trial of these 3 drugs in an open-label study.'?","Yes, this sentence does indirectly support the statement ""Artesunic acid treats Plasmodium vivax malaria"". The sentence mentions a comparative clinical trial for treating acute P. vivax malaria using artesunate, primaquine in high dose, and Fansidar (pyrimethamine and sulfadoxine). The fact that artesunate is being tested in a clinical trial for treating P. vivax malaria implies that it is being considered as a potential treatment for this strain, thus providing indirect support for its efficacy in treating P. vivax malaria. However, it is important to note that further investigation, such as reviewing the results and outcomes of this clinical trial, would be necessary to provide more direct evidence for its effectiveness as a treatment for P. vivax malaria." -7595063,Artesunic acid treats malaria,1487,Artemether and artesunate have also been administered by the rectal route with highly promising results for treatment of severe malaria.,True,Is the triple 'Artesunic acid treats malaria' supported by the sentence: 'Artemether and artesunate have also been administered by the rectal route with highly promising results for treatment of severe malaria.'?,"Yes, the statement is indirectly supported. Artesunic acid, Artemether, and Artesunate all belong to the same class of antimalarial drugs known as artemisinins, derived from the sweet wormwood plant (Artemisia annua). While Artesunic acid is not directly mentioned in the provided sentence, it falls under the umbrella of artemisinin-based combination therapies (ACTs) used for treating malaria, similar to Artemether and Artesunate. The promising results obtained from Artemether and Artesunate rectal administration suggest potential benefits for other artemisinin derivatives, such as Artesunic acid, in treating severe malaria, albeit further research is required to confirm this specifically for Artesunic acid." -7113713,Artesunic acid treats Plasmodium falciparum malaria,1488,Declining concentrations of dihydroartemisinin in plasma during 5-day oral treatment with artesunate for Falciparum malaria.,True,Is the triple 'Artesunic acid treats Plasmodium falciparum malaria' supported by the sentence: 'Declining concentrations of dihydroartemisinin in plasma during 5-day oral treatment with artesunate for Falciparum malaria.'?,"Yes, this sentence does indirectly support the statement about Artesunic acid treating Plasmodium falciparum malaria. The sentence mentions declining concentrations of dihydroartemisinin in plasma during 5-day oral treatment with artesunate for Falciparum malaria. Artesunate is a derivative of artemisinin, which is the active ingredient in Artesunic acid, used in treating malaria caused by Plasmodium falciparum. The fact that artesunate is effective in reducing dihydroartemisinin concentrations indicates its efficacy in treating Falciparum malaria, thus supporting Artesunic acid as an effective treatment for this type of malaria as well." -7264251,Artemether treats malaria,1489,These data demonstrate the equality of artemether and quinine for severe malaria and indicate a trend toward greater effectiveness of artemether in regions where there is recognized quinine resistance.,True,Is the triple 'Artemether treats malaria' supported by the sentence: 'These data demonstrate the equality of artemether and quinine for severe malaria and indicate a trend toward greater effectiveness of artemether in regions where there is recognized quinine resistance.'?,"Yes, this statement does provide some support for the idea that Artemether is used to treat malaria, though it is not direct support as it does not explicitly state that Artemether is used to treat malaria, but rather implies it through its comparison to Quinine, another known treatment for malaria. The statement suggests Artemether is equally effective as Quinine for severe malaria, and potentially more effective in regions where there is recognized Quinine resistance, indicating its use in treating severe cases of malaria, which is in line with the statement that Artemether is used to treat malaria." -7168046,Artemether treats Plasmodium falciparum malaria,1490,"The spectrum of falciparum malaria treatment has recently broadened to include new drugs such as artemisinin, artemether or atovaquone/proguanil, the latter being as yet unauthorized in France.",True,"Is the triple 'Artemether treats Plasmodium falciparum malaria' supported by the sentence: 'The spectrum of falciparum malaria treatment has recently broadened to include new drugs such as artemisinin, artemether or atovaquone/proguanil, the latter being as yet unauthorized in France.'?","Yes, the statement is indirectly supported. The sentence mentions Artemether as one of the new drugs in the treatment spectrum for Plasmodium falciparum malaria, which implies it is used to treat this type of malaria." -25827221,Isoproterenol treats obstructive lung disease,1491,Investigation into isoprenaline resistance in patients with obstructive lung disease.,True,Is the triple 'Isoproterenol treats obstructive lung disease' supported by the sentence: 'Investigation into isoprenaline resistance in patients with obstructive lung disease.'?,"Yes, this sentence does indirectly support the statement that Isoproterenol, also known as Isoprenaline, treats obstructive lung disease. The investigation into isoprenaline resistance in patients with obstructive lung disease suggests that Isoprenaline is used in the treatment of this condition, and resistance to it could pose a problem for patients, implying its therapeutic role. However, it does not directly state that Isoprenaline treats obstructive lung disease, hence the qualifier 'indirectly'." -15441635,Isoproterenol treats lipoma,1492,AIM: The aim of this study was to evaluate the efficacy of isoproterenol and prednisolone in the treatment of subcutaneous lipomas.,False,Is the triple 'Isoproterenol treats lipoma' supported by the sentence: 'AIM: The aim of this study was to evaluate the efficacy of isoproterenol and prednisolone in the treatment of subcutaneous lipomas.'?,"No, the sentence does not indirectly support the statement ""Isoproterenol treats lipoma"". The sentence states that the aim of the study is to evaluate the efficacy of isoproterenol and prednisolone in the treatment of subcutaneous lipomas, but it does not confirm that isoproterenol alone is effective in treating lipomas." -13881275,Isoproterenol treats orthostatic hypotension,1493,"Microdialysate concentrations of the main neuronal metabolite of norepinephrine (NE) and dihydroxyphenylglycol (DHPG) were measured in skeletal muscle, and plasma concentrations of NE and DHPG were measured in response to i.v. tyramine, yohimbine, and isoproterenol, in patients with PD+NOH, patients with pure autonomic failure (PAF), which is characterized by generalized catecholaminergic denervation, and control subjects.",True,"Is the triple 'Isoproterenol treats orthostatic hypotension' supported by the sentence: 'Microdialysate concentrations of the main neuronal metabolite of norepinephrine (NE) and dihydroxyphenylglycol (DHPG) were measured in skeletal muscle, and plasma concentrations of NE and DHPG were measured in response to i.v. tyramine, yohimbine, and isoproterenol, in patients with PD+NOH, patients with pure autonomic failure (PAF), which is characterized by generalized catecholaminergic denervation, and control subjects.'?","Yes, this sentence does indirectly support the statement that Isoproterenol treats orthostatic hypotension (PD+NOH). The sentence mentions Isoproterenol in relation to neuronal metabolite measurements in patients with PD+NOH, which suggests its use in treating this condition. However, it does not explicitly state that Isoproterenol is used to treat orthostatic hypotension, hence the indirect support." -11481186,Isoproterenol treats atrial fibrillation,1494,"RESULTS: LAP series analysis shows a reduction of both LP and R index during isoproterenol infusion in SR and AF (RSR = 0.75 +/- 0.07 RSRISO = 0.69 +/- 0.10, p < 0.0001; RAF = 0.31 +/- 0.08 RAFISO = 0.26 +/- 0.09, p < 0.0001; LPSR = 99.99 +/- 0.001 LPSRISO = 99.97 +/- 0.03, p < 0.0001; LPAF = 69.46 +/- 21.55 LPAFISO = 55 +/- 24.75; p < 0.0001).",True,"Is the triple 'Isoproterenol treats atrial fibrillation' supported by the sentence: 'RESULTS: LAP series analysis shows a reduction of both LP and R index during isoproterenol infusion in SR and AF (RSR = 0.75 +/- 0.07 RSRISO = 0.69 +/- 0.10, p < 0.0001; RAF = 0.31 +/- 0.08 RAFISO = 0.26 +/- 0.09, p < 0.0001; LPSR = 99.99 +/- 0.001 LPSRISO = 99.97 +/- 0.03, p < 0.0001; LPAF = 69.46 +/- 21.55 LPAFISO = 55 +/- 24.75; p < 0.0001).'?","Yes, the sentence does provide indirect evidence for the statement ""Isoproterenol treats atrial fibrillation (AF)"". The results show that during isoproterenol infusion, there is a reduction in both LP and R index in both sinus rhythm (SR) and AF. Furthermore, there is a significant decrease in LPAF (atrial fibrillation wavefront length) after isoproterenol infusion, which suggests an effect on AF dynamics. However, it is important to note that this does not directly demonstrate that isoproterenol is used as a treatment for AF, but rather suggests it may have an impact on AF dynamics." -9565866,Isoproterenol treats obesity disorder,1495,Decreased responsiveness to isoproterenol in obesity may be due to defects downstream of adenylyl cyclase activation of cyclic AMP.,False,Is the triple 'Isoproterenol treats obesity disorder' supported by the sentence: 'Decreased responsiveness to isoproterenol in obesity may be due to defects downstream of adenylyl cyclase activation of cyclic AMP.'?,"No, this sentence does not indirectly support the statement that Isoproterenol treats obesity disorder. The sentence discusses decreased responsiveness to Isoproterenol in obesity, which suggests a potential negative effect, not a treatment effect." -8710440,Isoproterenol treats postural orthostatic tachycardia syndrome,1496,the responses of heart rate and the plasma cyclic AMP (cAMP) level to isoproterenol infusion in the supine position were evaluated in 10 POTS patients and 10 age-matched controls.,True,Is the triple 'Isoproterenol treats postural orthostatic tachycardia syndrome' supported by the sentence: 'the responses of heart rate and the plasma cyclic AMP (cAMP) level to isoproterenol infusion in the supine position were evaluated in 10 POTS patients and 10 age-matched controls.'?,"Yes, this sentence does provide indirect support for the statement ""Isoproterenol treats postural orthostatic tachycardia syndrome (POTS)"". The sentence mentions a study where isoproterenol infusion was used in supine POTS patients to evaluate heart rate responses and plasma cyclic AMP (cAMP) level. The fact that isoproterenol was used in this context suggests that it has some therapeutic relevance to POTS, even though it does not explicitly state so. However, it is important to note that further research is required to confirm this link, as this study only investigates its effects on heart rate and plasma cAMP level in supine position, not its overall efficacy as a treatment for POTS." -10687311,Metaproterenol treats obstructive lung disease,1497,ORCIPRENALINE IN TREATMENT OF AIRWAYS OBSTRUCTION IN CHRONIC BRONCHITIS.,True,Is the triple 'Metaproterenol treats obstructive lung disease' supported by the sentence: 'ORCIPRENALINE IN TREATMENT OF AIRWAYS OBSTRUCTION IN CHRONIC BRONCHITIS.'?,"Yes, this is indirectly supported because Metaproterenol and Orciprenaline (which is also known as Metaproterenol) are both beta-2 adrenergic agonists used in the treatment of asthma, COPD, and other conditions involving bronchospasm, such as chronic bronchitis. Therefore, it is reasonable to infer that if Orciprenaline is used to treat airways obstruction in chronic bronchitis, then Metaproterenol would have similar effects due to their shared mechanism of action in relaxing bronchial smooth muscles, thus alleviating airways obstruction in chronic bronchitis patients." -21781034,Bacitracin A treats Infection,1498,"Based on these observations, the combination of CBD and BAC is suggested to be a putative novel treatment in clinical settings for treatment of infections with antibiotic resistant Gram-positive bacteria.",True,"Is the triple 'Bacitracin A treats Infection' supported by the sentence: 'Based on these observations, the combination of CBD and BAC is suggested to be a putative novel treatment in clinical settings for treatment of infections with antibiotic resistant Gram-positive bacteria.'?","Yes, this statement does provide indirect support for the claim that Bacitracin A can treat infections, specifically antibiotic resistant Gram-positive bacteria, as it suggests BAC (presumably Bacitracin A) as part of a potential treatment for such infections when used in combination with CBD. However, it does not directly confirm that Bacitracin A alone can treat infections, only that it may be part of an effective treatment strategy when used in combination with CBD." -17678351,Bacitracin A treats bacterial infectious disease,1499,"Thus, the bacitracin and gramicidin S-based self-assembled nanopeptide ribbon may be a successful ointment formulation for bacterial infection control.",True,"Is the triple 'Bacitracin A treats bacterial infectious disease' supported by the sentence: 'Thus, the bacitracin and gramicidin S-based self-assembled nanopeptide ribbon may be a successful ointment formulation for bacterial infection control.'?","Yes, this statement can be seen as indirectly supporting the claim that bacitracin A treats bacterial infections. The sentence discusses a self-assembled nanopeptide ribbon made from bacitracin and gramicidin S, which is suggested to be effective in controlling bacterial infections. This implies that bacitracin, an ingredient in this formulation, has antibacterial properties, thus supporting its use in treating bacterial infections. However, it is important to note that this is an indirect inference, as the sentence does not directly mention bacitracin A's effectiveness in treating bacterial infections." -11891842,Bacitracin A treats burn,1500,"Consensus was found regarding most local (topical) wound care, (SSD for clean non-facial burns, Sulfamylon (mafenide-acetate) for contaminated non-facial burns, Threolone (chloramphenicol 3% and prednisolone 0.5%) or Bacitracin for facial burns, Paraffin gauzes with or without Sulfamylon for donor and graft sites).",True,"Is the triple 'Bacitracin A treats burn' supported by the sentence: 'Consensus was found regarding most local (topical) wound care, (SSD for clean non-facial burns, Sulfamylon (mafenide-acetate) for contaminated non-facial burns, Threolone (chloramphenicol 3% and prednisolone 0.5%) or Bacitracin for facial burns, Paraffin gauzes with or without Sulfamylon for donor and graft sites).'?","Yes, this statement indirectly supports that Bacitracin A is used to treat facial burns, as mentioned in the sentence provided. The consensus statement lists Bacitracin as one of the options for local wound care specifically for facial burns, which implies its use in treating such cases, although the exact mechanism through which Bacitracin A contributes to treating burns is not explicitly stated in this sentence." -26452786,Fenbendazole causes helminthiasis,101,The anti-ischemic mechanism of action of ranolazine in stable ischemic heart disease.,False,Is the triple 'Fenbendazole causes helminthiasis' supported by the sentence: 'The anti-ischemic mechanism of action of ranolazine in stable ischemic heart disease.'?,"No, this statement is not supported by the sentence provided. Fenbendazole is an anthelmintic drug used to treat parasitic worm infections, also known as helminthiasis, while ranolazine is used to treat chronic angina, a type of ischemic heart disease. There is no direct or indirect connection between these two drugs or their respective mechanisms of action in the sentence provided." -22762728,Fenbendazole prevents helminthiasis,102,Atrial-selective/predominant sodium channel blockers such as ranolazine effectively suppress AF in experimental models of AF involving canine isolated right atrial preparations at concentrations that produce little to no effect on ventricular electrophysiologic parameters.,False,Is the triple 'Fenbendazole prevents helminthiasis' supported by the sentence: 'Atrial-selective/predominant sodium channel blockers such as ranolazine effectively suppress AF in experimental models of AF involving canine isolated right atrial preparations at concentrations that produce little to no effect on ventricular electrophysiologic parameters.'?,"No, this statement does not provide indirect support for the claim that Fenbendazole prevents helminthiasis. The sentence discusses the effects of atrial-selective sodium channel blockers on atrial fibrillation (AF) in canine models, but it does not mention Fenbendazole, helminthiasis, or any related parasitic infections. Helminthiasis is a condition caused by parasitic worms, and Fenbendazole is an anthelmintic drug used to treat such infections. Therefore, this sentence does not offer any relevant context or evidence to support the claim about Fenbendazole preventing helminthiasis." -21848143,Albendazole causes helminthiasis,103,Ranolazine has been shown to decrease angina pectoris frequency and nitroglycerin consumption.,False,Is the triple 'Albendazole causes helminthiasis' supported by the sentence: 'Ranolazine has been shown to decrease angina pectoris frequency and nitroglycerin consumption.'?,"No, this statement is not supported by the given sentence. The sentence only mentions two drugs, Ranolazine, which decreases angina pectoris frequency and nitroglycerin consumption, but it does not mention anything about Albendazole, helminthiasis, or their indirect relationship." -25735916,Albendazole affects trichuriasis,104,BACKGROUND: Ranolazine has been shown to reduce myocardial ischemia and symptom severity among selected patients with chronic angina.,False,Is the triple 'Albendazole affects trichuriasis' supported by the sentence: 'BACKGROUND: Ranolazine has been shown to reduce myocardial ischemia and symptom severity among selected patients with chronic angina.'?,"No, this sentence does not provide any support for the statement about Albendazole affecting trichuriasis, as it discusses Ranolazine's effect on myocardial ischemia and symptom severity in patients with chronic angina, not about Albendazole or trichuriasis." -24685635,Albendazole affects filarial elephantiasis,105,"Dominant frequency (DF) of AF was reduced by ranolazine in left atrium from 11.7 (10.7-20.5) Hz to 7.6 (2.9-8.8) Hz (P = 0.02, n = 6).",False,"Is the triple 'Albendazole affects filarial elephantiasis' supported by the sentence: 'Dominant frequency (DF) of AF was reduced by ranolazine in left atrium from 11.7 (10.7-20.5) Hz to 7.6 (2.9-8.8) Hz (P = 0.02, n = 6).'?","No, this sentence does not provide any support for the statement that Albendazole affects filarial elephantiasis, directly or indirectly. The sentence mentions ranolazine, its effect on atrial fibrillation (AF) frequency, but it does not mention Albendazole, filariasis, or elephantiasis at all. Therefore, it does not provide any indirect evidence either." -18452252,Albendazole affects toxocariasis,106,"After adjusting for potential sources of bias through propensity-score matched-pair analysis and conditional logistic regression, ranolazine was an independent predictor of preventing POAF (p < 0.0001).",False,"Is the triple 'Albendazole affects toxocariasis' supported by the sentence: 'After adjusting for potential sources of bias through propensity-score matched-pair analysis and conditional logistic regression, ranolazine was an independent predictor of preventing POAF (p < 0.0001).'?","No, this statement does not provide any support for the triple ""Albendazole affects toxocariasis"". The sentence discusses the relationship between ranolazine and preventing post-operative atrial fibrillation (POAF), not albendazole and toxocariasis." -16658505,Albendazole affects malaria,107,Prednisolone furthers T-cell immunodeficiency and also reduces the intensity of autoimmune reactions in multiple sclerosis.,False,Is the triple 'Albendazole affects malaria' supported by the sentence: 'Prednisolone furthers T-cell immunodeficiency and also reduces the intensity of autoimmune reactions in multiple sclerosis.'?,"No, this statement does not provide indirect support for the idea that Albendazole affects malaria. The sentence discusses Prednisolone, its effect on T-cell immunodeficiency, and its role in reducing autoimmune reactions in multiple sclerosis. There is no mention or implication of Albendazole, its effects, or its relation to malaria in this statement." -13946207,Albendazole affects helminthiasis,108,[Pharmacokinetics of prednisolone in adrenal insufficiency ].,False,Is the triple 'Albendazole affects helminthiasis' supported by the sentence: '[Pharmacokinetics of prednisolone in adrenal insufficiency ].'?,"No, this sentence does not provide any support for the claim that Albendazole affects helminthiasis, directly or indirectly. The sentence discusses pharmacokinetics, which refers to the process of how a drug is absorbed, distributed, metabolized, and excreted in an organism, but it does not mention anything about Albendazole or its effects on helminthiasis." -11239060,Albendazole affects filariasis,109,It is concluded that VAP is effective therapy in AIL.,False,Is the triple 'Albendazole affects filariasis' supported by the sentence: 'It is concluded that VAP is effective therapy in AIL.'?,"No, it is not directly supported. The sentence ""It is concluded that VAP is effective therapy in AIL."" is referring to Visceral Leishmaniasis (AIL) treated with meglumine antimoniate (VAP), not Filariasis treated with Albendazole. However, it is possible that Albendazole could affect Filariasis indirectly through some other mechanism, but this sentence does not provide evidence for that." -24729219,Albendazole disrupts helminthiasis,110,A thermographic assessment of three intra-articular prednisolone analogues given in rheumatoid synovitis.,False,Is the triple 'Albendazole disrupts helminthiasis' supported by the sentence: 'A thermographic assessment of three intra-articular prednisolone analogues given in rheumatoid synovitis.'?,"No, this sentence does not provide any indirect support for the statement ""Albendazole disrupts helminthiasis."" The sentence discusses rheumatoid synovitis, which is an inflammatory condition affecting synovial tissue in joints, and mentions three intra-articular prednisolone analogues, which are likely drugs used to treat this condition based on the context provided in the sentence. However, there is no mention or implication of any relationship between these drugs, rheumatoid synovitis, and Albendazole, which is an antiparasitic medication used to treat certain types of worm infestations, including helminthiasis." -16658503,Albendazole disrupts malaria,111,The effect of small doses of prednisolone on the incidence of subcutaneous sarcomas induced by 3-methylcholanthrene in virgin female Swiss mice.,False,Is the triple 'Albendazole disrupts malaria' supported by the sentence: 'The effect of small doses of prednisolone on the incidence of subcutaneous sarcomas induced by 3-methylcholanthrene in virgin female Swiss mice.'?,"No, this statement does not provide any support, directly or indirectly, for the claim that Albendazole disrupts malaria. The sentence you provided discusses the effect of prednisolone on subcutaneous sarcomas in mice, which is unrelated to Albendazole and malaria." -13637338,Albendazole disrupts Hookworm Infections,112,[Effects of chromocarb diethylamine and prednisolone in experimental uveitis induced by clove oil in rabbits].,False,Is the triple 'Albendazole disrupts Hookworm Infections' supported by the sentence: '[Effects of chromocarb diethylamine and prednisolone in experimental uveitis induced by clove oil in rabbits].'?,"No, this sentence does not provide any support, direct or indirect, for the statement ""Albendazole disrupts Hookworm Infections"". The sentence you provided discusses the effects of chromocarb diethylamine and prednisolone in experimental uveitis induced by clove oil in rabbits, which is unrelated to albendazole or hookworm infections." -15248433,Albendazole prevents filariasis,113,[Effect of prednisolone and heparin on circulating T- and B-lymphocytes in glomerulonephritis and systemic lupus erythematosus].,False,Is the triple 'Albendazole prevents filariasis' supported by the sentence: '[Effect of prednisolone and heparin on circulating T- and B-lymphocytes in glomerulonephritis and systemic lupus erythematosus].'?,"No, this statement is not indirectly supported by the given sentence. The sentence discusses the effect of prednisolone and heparin on circulating T- and B-lymphocytes in glomerulonephritis and systemic lupus erythematosus, which is unrelated to albendazole, filariasis, or their interaction." -13732336,Albendazole prevents helminthiasis,114,[Effects of prednisolone on thyroidal-123I uptake in subacute thyroiditis].,False,Is the triple 'Albendazole prevents helminthiasis' supported by the sentence: '[Effects of prednisolone on thyroidal-123I uptake in subacute thyroiditis].'?,"No, this statement is not supported by the provided sentence. The sentence discusses the effects of prednisolone on thyroidal-123I uptake in subacute thyroiditis, which is unrelated to albendazole, helminthiasis, or any related concepts." -15316470,Ibuprofen subclass of 2-Hydroxyibuprofen,115,"Blood Eosinophil Depletion with Mepolizumab, Benralizumab and Prednisolone in Eosinophilic Asthma.",False,"Is the triple 'Ibuprofen subclass of 2-Hydroxyibuprofen' supported by the sentence: 'Blood Eosinophil Depletion with Mepolizumab, Benralizumab and Prednisolone in Eosinophilic Asthma.'?","No, this statement does not provide any direct or indirect support for the claim that Ibuprofen is a subclass of 2-Hydroxyibuprofen, nor does it suggest any relationship between these compounds and Mepolizumab, Benralizumab, Prednisolone, or Eosinophilic Asthma. The statement discusses blood eosinophil depletion in eosinophilic asthma using certain medications, but it does not provide any relevant information about the classification or relationship between Ibuprofen and 2-Hydroxyibuprofen." -16265626,Ibuprofen related to Arthralgia,116,[Prednisolone and aspirin combination therapy in habitual abortion with autoantibodies].,False,Is the triple 'Ibuprofen related to Arthralgia' supported by the sentence: '[Prednisolone and aspirin combination therapy in habitual abortion with autoantibodies].'?,"No, there is no direct or indirect mention of Ibuprofen, arthralgia, or their relationship in this sentence about Prednisolone, aspirin, habitual abortion, autoantibodies, and potential side effects like arthralgia from Prednisolone use, but not Ibuprofen in particular." -14582794,Ibuprofen related to Pain,117,"To illustrate this, we used an example of cost-effectiveness analysis for docetaxel in combination with prednisolone in metastatic hormone-refractory prostate cancer.",False,"Is the triple 'Ibuprofen related to Pain' supported by the sentence: 'To illustrate this, we used an example of cost-effectiveness analysis for docetaxel in combination with prednisolone in metastatic hormone-refractory prostate cancer.'?","No, this statement does not provide any direct or indirect support for the triple query ""Ibuprofen is related to Pain"". The statement discusses a cost-effectiveness analysis for docetaxel in combination with prednisolone in metastatic hormone-refractory prostate cancer. Ibuprofen, which is a non-steroidal anti-inflammatory drug (NSAID) used primarily for its analgesic (pain-relieving), antipyretic (fever-reducing), and anti-inflammatory effects, is not mentioned in this context, nor is it connected in any way." -11440746,Ibuprofen related to Toothache,118,Prednisolone is associated with a worse bone mineral density in primary adrenal insufficiency.,False,Is the triple 'Ibuprofen related to Toothache' supported by the sentence: 'Prednisolone is associated with a worse bone mineral density in primary adrenal insufficiency.'?,"No, this sentence does not provide any support for the relationship between Ibuprofen and toothache, directly or indirectly, because it discusses Prednisolone and bone mineral density in primary adrenal insufficiency, not Ibuprofen or toothache." -9106384,Ibuprofen related to osteoarthritis,119,CONCLUSIONS: Prednisolone was more effective in inducing response than itraconazole in acute-stage ABPA.,False,Is the triple 'Ibuprofen related to osteoarthritis' supported by the sentence: 'CONCLUSIONS: Prednisolone was more effective in inducing response than itraconazole in acute-stage ABPA.'?,"No, this sentence does not provide any support for the statement that ibuprofen is related to osteoarthritis, directly or indirectly. The sentence discusses the effectiveness of prednisolone versus itraconazole in acute-stage allergic bronchopulmonary aspergillosis (ABPA), which is an allergic reaction to the fungus Aspergillus in people with cystic fibrosis or asthma. Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) commonly used for pain relief, fever reduction, and inflammation, while osteoarthritis is a degenerative joint disease. There is no connection between these two in this sentence." -8106985,Ibuprofen related to burn,120,"Purpose: The aim of this study was to compare asparaginase-related toxicities in two asparaginase preparations, namely native Escherichia coli L-asparaginase (L-ASP) and pegylated asparaginase (PEG-ASP) in combination with ifosfamide, methotrexate, etoposide, and prednisolone (IMEP) in natural killer (NK)/T-cell lymphoma (NTCL).",False,"Is the triple 'Ibuprofen related to burn' supported by the sentence: 'Purpose: The aim of this study was to compare asparaginase-related toxicities in two asparaginase preparations, namely native Escherichia coli L-asparaginase (L-ASP) and pegylated asparaginase (PEG-ASP) in combination with ifosfamide, methotrexate, etoposide, and prednisolone (IMEP) in natural killer (NK)/T-cell lymphoma (NTCL).'?","No, the sentence does not provide any indirect support for the claim that Ibuprofen is related to burn in any way. This sentence discusses a study comparing asparaginase-related toxicities in two asparaginase preparations when used in combination with ifosfamide, methotrexate, etoposide, and prednisolone for treating natural killer (NK)/T-cell lymphoma (NTCL). The sentence does not mention Ibuprofen, nor does it mention any relationship between Ibuprofen and burns." -13726345,Ibuprofen causes patent ductus arteriosus,121,Prednisolone combined with adjunctive immunosuppression is not superior to prednisolone alone in terms of efficacy and safety in giant cell arteritis: meta-analysis.,False,Is the triple 'Ibuprofen causes patent ductus arteriosus' supported by the sentence: 'Prednisolone combined with adjunctive immunosuppression is not superior to prednisolone alone in terms of efficacy and safety in giant cell arteritis: meta-analysis.'?,"No, this statement does not provide any indirect support for the claim that Ibuprofen causes patent ductus arteriosus. The sentence discusses the efficacy and safety of prednisolone, either alone or combined with immunosuppression, in treating giant cell arteritis. It does not mention Ibuprofen or any related conditions such as patent ductus arteriosus." -13653982,Ibuprofen causes Alzheimer disease,122,CONCLUSION: GVP is well-tolerated regimen with high response rate and needs to be tested in late relapsed HL.,False,Is the triple 'Ibuprofen causes Alzheimer disease' supported by the sentence: 'CONCLUSION: GVP is well-tolerated regimen with high response rate and needs to be tested in late relapsed HL.'?,"No, this sentence does not provide any indirect support for the claim that Ibuprofen causes Alzheimer's disease. The sentence discusses the safety and response rate of a treatment regimen (GVP) in late relapsed Hodgkin Lymphoma (HL), but it does not mention Ibuprofen or Alzheimer's disease." -13133316,Ibuprofen causes peptic ulcer disease,123,Early treatment with addition of low dose prednisolone to methotrexate improves therapeutic outcome in severe psoriatic arthritis.,False,Is the triple 'Ibuprofen causes peptic ulcer disease' supported by the sentence: 'Early treatment with addition of low dose prednisolone to methotrexate improves therapeutic outcome in severe psoriatic arthritis.'?,"No, this statement does not provide any indirect support for the claim that Ibuprofen causes peptic ulcer disease. The sentence discusses the therapeutic outcomes of treating severe psoriatic arthritis with methotrexate and low-dose prednisolone, but it does not mention Ibuprofen or any related side effects like peptic ulcers." -12641386,Ibuprofen causes Fever,124,"CONCLUSION: Flu/Cy/ATG conditioning regimen, bone marrow as stem cell source and CSA, prednisolone and short methotrexate regimen were associated with better survival in AA.",False,"Is the triple 'Ibuprofen causes Fever' supported by the sentence: 'CONCLUSION: Flu/Cy/ATG conditioning regimen, bone marrow as stem cell source and CSA, prednisolone and short methotrexate regimen were associated with better survival in AA.'?","No, this statement does not support the claim that Ibuprofen causes fever. In fact, it seems to be discussing a study or conclusion related to stem cell transplantation in patients with AA (Aplastic Anemia). The terms mentioned, such as Flu/Cy/ATG conditioning regimen, bone marrow as stem cell source, CSA, prednisolone, and short methotrexate regimen, are common terms in medical literature related to transplantation procedures and immunosuppressive therapies. There is no mention or implication of Ibuprofen in this statement, nor does it suggest any connection to fever." -12482174,Ibuprofen causes pancreatitis,125,Effect of addition of short course of prednisolone to gluten-free diet on mucosal epithelial cell regeneration and apoptosis in celiac disease: a pilot randomized controlled trial.,False,Is the triple 'Ibuprofen causes pancreatitis' supported by the sentence: 'Effect of addition of short course of prednisolone to gluten-free diet on mucosal epithelial cell regeneration and apoptosis in celiac disease: a pilot randomized controlled trial.'?,"No, this statement does not provide any indirect support for the claim that Ibuprofen causes pancreatitis. The sentence is about a pilot randomized controlled trial studying the effect of adding a short course of prednisolone to a gluten-free diet on mucosal epithelial cell regeneration and apoptosis in celiac disease, which is unrelated to Ibuprofen or its potential side effects on the pancreas." -12438812,Ibuprofen causes Toothache,126,Coadministration of cyclosporin a with prednisolone in acute interstitial pneumonia complicating polymyositis/dermatomyositis.,False,Is the triple 'Ibuprofen causes Toothache' supported by the sentence: 'Coadministration of cyclosporin a with prednisolone in acute interstitial pneumonia complicating polymyositis/dermatomyositis.'?,"No, this statement does not provide any indirect support for the claim that Ibuprofen causes toothache. The sentence discusses coadministration of cyclosporin a with prednisolone in acute interstitial pneumonia complicating polymyositis/dermatomyositis, which is unrelated to Ibuprofen or toothache." -12079834,Ibuprofen causes adult acute respiratory distress syndrome,127,"Efficacy of immunoglobulin plus prednisolone for prevention of coronary artery abnormalities in severe Kawasaki disease (RAISE study): a randomised, open-label, blinded-endpoints trial.",False,"Is the triple 'Ibuprofen causes adult acute respiratory distress syndrome' supported by the sentence: 'Efficacy of immunoglobulin plus prednisolone for prevention of coronary artery abnormalities in severe Kawasaki disease (RAISE study): a randomised, open-label, blinded-endpoints trial.'?","No, this statement is not indirectly supported by this sentence. The sentence is about a study on Kawasaki disease, which is an illness primarily affecting children, causing inflammation in blood vessels throughout the body, particularly those in the heart. Ibuprofen is not mentioned in this sentence, nor is there any connection made to acute respiratory distress syndrome in adults." -11157616,Ibuprofen causes Pain,128,"Response of vincristine, melphalan, cyclophosphamide and prednisolone in refractory multiple myeloma.",False,"Is the triple 'Ibuprofen causes Pain' supported by the sentence: 'Response of vincristine, melphalan, cyclophosphamide and prednisolone in refractory multiple myeloma.'?","No, this statement does not provide any support for the claim that Ibuprofen causes pain. The sentence discusses the response of certain drugs, including prednisolone, in refractory multiple myeloma, but it does not mention Ibuprofen or pain. Therefore, it does not provide any indirect support for the claim." -10429873,Ibuprofen causes Hemorrhage,129,Pyruvate kinase M2 and prednisolone resistance in acute lymphoblastic leukemia.,False,Is the triple 'Ibuprofen causes Hemorrhage' supported by the sentence: 'Pyruvate kinase M2 and prednisolone resistance in acute lymphoblastic leukemia.'?,"No, this statement does not provide indirect support for the claim that Ibuprofen causes hemorrhage. The sentence ""Pyruvate kinase M2 and prednisolone resistance in acute lymphoblastic leukemia."" does not mention Ibuprofen or hemorrhage, so there is no clear connection between the two statements." -9800201,Ibuprofen causes arthritic joint disease,130,"Stimulation with prednisolone and TNFalpha reduced GDF-5 expression in OA and RA fibroblasts, whereas MTX and IL-1beta revealed minor or no relevant change.",False,"Is the triple 'Ibuprofen causes arthritic joint disease' supported by the sentence: 'Stimulation with prednisolone and TNFalpha reduced GDF-5 expression in OA and RA fibroblasts, whereas MTX and IL-1beta revealed minor or no relevant change.'?","No, this sentence does not support the claim that Ibuprofen causes arthritic joint disease. The sentence discusses the effects of various substances on GDF-5 expression in OA (osteoarthritis) and RA (rheumatoid arthritis) fibroblasts, but it does not mention Ibuprofen at all. Therefore, it does not provide any evidence for or against the effects of Ibuprofen on arthritis." -8163776,Ibuprofen causes injury,131,"A combination of rituximab plus chemotherapy, rituximab+cyclophosphamide+doxorubicin+vincristine+prednisolone (R-CHOP), has the highest efficacy ever described with any chemotherapy in DLBCL and FL.",False,"Is the triple 'Ibuprofen causes injury' supported by the sentence: 'A combination of rituximab plus chemotherapy, rituximab+cyclophosphamide+doxorubicin+vincristine+prednisolone (R-CHOP), has the highest efficacy ever described with any chemotherapy in DLBCL and FL.'?","No, this sentence does not provide any direct or indirect evidence to support the statement that ibuprofen causes injury in any context. The sentence discusses the efficacy of a specific chemotherapy regimen (R-CHOP) in treating certain types of lymphoma (DLBCL and FL), but it does not mention ibuprofen or any related side effects." -26701175,Ibuprofen affects rheumatoid arthritis,132,"A combination of rituximab plus chemotherapy, rituximab+cyclophosphamide+doxorubicin+vincristine+prednisolone (R-CHOP), has the highest efficacy ever described with any chemotherapy in DLBCL and FL.",False,"Is the triple 'Ibuprofen affects rheumatoid arthritis' supported by the sentence: 'A combination of rituximab plus chemotherapy, rituximab+cyclophosphamide+doxorubicin+vincristine+prednisolone (R-CHOP), has the highest efficacy ever described with any chemotherapy in DLBCL and FL.'?","No, this sentence does not provide any indirect support for the claim that Ibuprofen affects rheumatoid arthritis. The sentence discusses the efficacy of a specific chemotherapy regimen (R-CHOP) in treating certain types of lymphoma (DLBCL and FL). It does not mention Ibuprofen, rheumatoid arthritis, or any related concepts. Therefore, it does not provide any relevant information to support or refute the claim." -24384432,Ibuprofen affects migraine disorder,133,Weekly docetaxel and prednisolone versus prednisolone alone in androgen-independent prostate cancer: a randomized phase II study.,False,Is the triple 'Ibuprofen affects migraine disorder' supported by the sentence: 'Weekly docetaxel and prednisolone versus prednisolone alone in androgen-independent prostate cancer: a randomized phase II study.'?,"No, this statement does not provide any indirect support for the claim that Ibuprofen affects migraine disorder. The sentence discusses a randomized phase II study on weekly docetaxel and prednisolone versus prednisolone alone in treating androgen-independent prostate cancer, which is unrelated to Ibuprofen or its effects on migraines." -23500890,Ibuprofen affects adult acute respiratory distress syndrome,134,Prednisolone and azathioprine in membranous nephropathy: a 10-year follow-up study.,False,Is the triple 'Ibuprofen affects adult acute respiratory distress syndrome' supported by the sentence: 'Prednisolone and azathioprine in membranous nephropathy: a 10-year follow-up study.'?,"No, this sentence does not provide any direct or indirect support for the statement that Ibuprofen affects adult acute respiratory distress syndrome. The sentence discusses the use of prednisolone and azathioprine in membranous nephropathy, which is a kidney disease, and does not mention Ibuprofen or any related conditions." -21214366,Ibuprofen affects bronchopulmonary dysplasia,135,"Taken together, the present study points to a strong inhibitory effect of liposomal PLP on tumor angiogenesis by reduction of the intratumoral production of the majority of pro-angiogenic factors studied and direct inhibition of endothelial cell proliferation, which is the result of high prolonged levels of prednisolone in the tumor by liposomal delivery.",False,"Is the triple 'Ibuprofen affects bronchopulmonary dysplasia' supported by the sentence: 'Taken together, the present study points to a strong inhibitory effect of liposomal PLP on tumor angiogenesis by reduction of the intratumoral production of the majority of pro-angiogenic factors studied and direct inhibition of endothelial cell proliferation, which is the result of high prolonged levels of prednisolone in the tumor by liposomal delivery.'?","No, this sentence does not provide any direct or indirect support for the statement that Ibuprofen affects bronchopulmonary dysplasia. The sentence discusses the inhibitory effect of liposomal PLP on tumor angiogenesis, which is not related to Ibuprofen or bronchopulmonary dysplasia." -20886939,Ibuprofen affects Cognitive impairment,136,Prednisolone versus dexamethasone in croup: a randomised equivalence trial.,False,Is the triple 'Ibuprofen affects Cognitive impairment' supported by the sentence: 'Prednisolone versus dexamethasone in croup: a randomised equivalence trial.'?,"No, this statement does not provide any indirect support for the claim that Ibuprofen affects cognitive impairment. The study mentioned is about comparing the effects of Prednisolone and Dexamethasone in treating croup, not about Ibuprofen or cognitive impairment." -18977843,Ibuprofen affects Headache,137,Use of ACTH and prednisolone in infantile spasms: experience from a developing country.,False,Is the triple 'Ibuprofen affects Headache' supported by the sentence: 'Use of ACTH and prednisolone in infantile spasms: experience from a developing country.'?,"No, this statement is not supported by the provided sentence. The sentence discusses the use of ACTH (Adrenocorticotropic hormone) and prednisolone in treating infantile spasms, which is not related to the usage, effects, or impact of Ibuprofen on headaches." -15746938,Ibuprofen affects injury,138,Bone mineral density in relation to efficacy and side effects of budesonide and prednisolone in Crohn's disease.,False,Is the triple 'Ibuprofen affects injury' supported by the sentence: 'Bone mineral density in relation to efficacy and side effects of budesonide and prednisolone in Crohn's disease.'?,"No, this statement does not provide direct or indirect support for the idea that ibuprofen affects injury. The sentence discusses bone mineral density in relation to budesonide and prednisolone, which are medications used to treat Crohn's disease, but it does not mention ibuprofen or any related effects on injury." -13826486,Ibuprofen affects osteoarthritis,139,OBJECTIVE: To examine the safety and efficacy of methotrexate (MTX) plus low-dose prednisolone for induction of remission in non life- or organ-threatening courses and for remission maintenance in Churg-Strauss syndrome (CSS).,False,Is the triple 'Ibuprofen affects osteoarthritis' supported by the sentence: 'OBJECTIVE: To examine the safety and efficacy of methotrexate (MTX) plus low-dose prednisolone for induction of remission in non life- or organ-threatening courses and for remission maintenance in Churg-Strauss syndrome (CSS).'?,"No, this sentence does not provide any evidence to indirectly support the statement that Ibuprofen affects osteoarthritis. The sentence discusses an objective to examine the safety and efficacy of methotrexate (MTX) plus low-dose prednisolone for induction of remission in non life- or organ-threatening courses and for remission maintenance in Churg-Strauss syndrome (CSS). It does not mention Ibuprofen or its effects on osteoarthritis." -13584223,Ibuprofen affects Cognitive impairment,140,OBJECTIVE: To determine whether addition of low dose prednisolone to multidrug treatment can prevent reaction and nerve function impairment in leprosy.,False,Is the triple 'Ibuprofen affects Cognitive impairment' supported by the sentence: 'OBJECTIVE: To determine whether addition of low dose prednisolone to multidrug treatment can prevent reaction and nerve function impairment in leprosy.'?,"No, this sentence does not provide any support for the relationship between Ibuprofen, cognitive impairment, and leprosy treatment. The sentence is about a study on leprosy treatment, specifically adding low-dose prednisolone to multidrug treatment, to prevent reaction and nerve function impairment in leprosy patients. There is no mention or implication of Ibuprofen, cognitive function, or cognitive impairment in this sentence." -12659717,Ibuprofen affects Fever,141,A double-blind randomized controlled trial of infliximab associated with prednisolone in acute alcoholic hepatitis.,False,Is the triple 'Ibuprofen affects Fever' supported by the sentence: 'A double-blind randomized controlled trial of infliximab associated with prednisolone in acute alcoholic hepatitis.'?,"No, this statement does not provide direct or indirect support for the claim that Ibuprofen affects fever. The sentence discusses a trial involving infliximab and prednisolone in acute alcoholic hepatitis, making no mention of Ibuprofen, fever, or their relationship." -11207850,Ibuprofen affects peptic ulcer disease,142,EULAR randomised controlled trial of pulse cyclophosphamide and methylprednisolone versus continuous cyclophosphamide and prednisolone followed by azathioprine and prednisolone in lupus nephritis.,False,Is the triple 'Ibuprofen affects peptic ulcer disease' supported by the sentence: 'EULAR randomised controlled trial of pulse cyclophosphamide and methylprednisolone versus continuous cyclophosphamide and prednisolone followed by azathioprine and prednisolone in lupus nephritis.'?,"No, this statement does not provide any direct or indirect support for the idea that ibuprofen affects peptic ulcer disease. The EULAR randomised controlled trial mentioned in the statement is about the treatment of lupus nephritis, not about ibuprofen or peptic ulcers. Therefore, it does not contribute to our understanding of the relationship between ibuprofen and peptic ulcer disease." -11159990,Ibuprofen affects Hemorrhage,143,OBJECTIVE: To investigate the safety and efficacy of leflunomide plus low-dose prednisolone for the maintenance of remission in Wegener's granulomatosis (WG).,False,Is the triple 'Ibuprofen affects Hemorrhage' supported by the sentence: 'OBJECTIVE: To investigate the safety and efficacy of leflunomide plus low-dose prednisolone for the maintenance of remission in Wegener's granulomatosis (WG).'?,"No, this statement does not provide any evidence to support an indirect relationship between Ibuprofen, hemorrhage, leflunomide, low-dose prednisolone, and Wegener’s granulomatosis (WG). The objective statement discusses an investigation into the safety and efficacy of leflunomide plus low-dose prednisolone for maintaining remission in Wegener’s granulomatosis, but it does not mention Ibuprofen or hemorrhage in any capacity." -10170540,Ibuprofen affects patent ductus arteriosus,144,"Treatment with combined therapy of adriamycin, vincristine and prednisolone produced a remission in the leukaemia with complete resolution of the breast mass.",False,"Is the triple 'Ibuprofen affects patent ductus arteriosus' supported by the sentence: 'Treatment with combined therapy of adriamycin, vincristine and prednisolone produced a remission in the leukaemia with complete resolution of the breast mass.'?","No, this sentence does not support the statement that Ibuprofen affects patent ductus arteriosus, directly or indirectly. The sentence discusses the treatment of leukaemia using adriamycin, vincristine, and prednisolone, but it does not mention Ibuprofen or any related conditions such as patent ductus arteriosus." -10026104,Ibuprofen affects Myalgia,145,RESULTS: The average initial dose of prednisolone in polymyalgia rheumatica was 35 mg; 51 of 62 patients were given a starting dose exceeding 15 mg.,False,Is the triple 'Ibuprofen affects Myalgia' supported by the sentence: 'RESULTS: The average initial dose of prednisolone in polymyalgia rheumatica was 35 mg; 51 of 62 patients were given a starting dose exceeding 15 mg.'?,"No, this sentence does not provide any support for the statement that Ibuprofen affects myalgia, either directly or indirectly. The sentence is about the initial dose of prednisolone in polymyalgia rheumatica patients, not about Ibuprofen or myalgia." -9889792,Ibuprofen affects Hemorrhage,146,[Trans-utero-tubal administration of prednisolone in sterility caused by obstruction of the tubes].,False,Is the triple 'Ibuprofen affects Hemorrhage' supported by the sentence: '[Trans-utero-tubal administration of prednisolone in sterility caused by obstruction of the tubes].'?,"No, this sentence does not provide any support for the statement that Ibuprofen affects hemorrhage, directly or indirectly. The sentence is about trans-utero-tubal administration of prednisolone in sterility caused by obstruction of the tubes, which is not related to Ibuprofen or hemorrhage." -8819538,Ibuprofen affects osteoarthritis,147,[On experiences with a combination preparation from prednisolone and an antihistaminic in dermatology especially in endogenous eczema].,False,Is the triple 'Ibuprofen affects osteoarthritis' supported by the sentence: '[On experiences with a combination preparation from prednisolone and an antihistaminic in dermatology especially in endogenous eczema].'?,"No, this sentence does not provide any support for the statement that Ibuprofen affects osteoarthritis, directly or indirectly. The sentence is about a combination preparation from prednisolone and an antihistaminic in dermatology, especially in endogenous eczema, which is not related to Ibuprofen or osteoarthritis." -8421263,Ibuprofen affects Fever,148,[USE OF PREDNISOLONE IN SOME GRAVE FORMS OF PATHOLOGY OF THE PREMATURE INFANT].,False,Is the triple 'Ibuprofen affects Fever' supported by the sentence: '[USE OF PREDNISOLONE IN SOME GRAVE FORMS OF PATHOLOGY OF THE PREMATURE INFANT].'?,"No, this sentence does not provide any indirect support for the statement that Ibuprofen affects fever. The sentence is about the use of Prednisolone in some grave forms of pathology in premature infants, which does not relate to Ibuprofen or fever." -27630106,Ibuprofen disrupts Acute Pain,149,[EFFECT OF PREDNISOLONE ON THE CARDIAC ACTIVITY IN LIVER AND KIDNEY DISEASES AND IN RHEUMATISM].,False,Is the triple 'Ibuprofen disrupts Acute Pain' supported by the sentence: '[EFFECT OF PREDNISOLONE ON THE CARDIAC ACTIVITY IN LIVER AND KIDNEY DISEASES AND IN RHEUMATISM].'?,"No, this sentence does not provide any indirect support for the statement ""Ibuprofen disrupts Acute Pain"". The sentence discusses the effect of Prednisolone on cardiac activity in liver and kidney diseases and in rheumatism, which is unrelated to Ibuprofen's effect on acute pain." -23399675,Ibuprofen disrupts Myalgia,150,"In this limited pilot study, we compared the effect on clinical outcome of treating Pseudomonas keratitis in guinea pigs with prednisolone (a corticosteroid), flurbiprofen (a cyclo-oxygenase inhibitor), nordihydroguaiaretic acid (a lipoxygenase inhibitor), and a leukotriene antagonist, SKF104353 [R-(R*, S*)]-beta-[(2-carboxyethyl) thio-alpha-hydroxy-2-(8-phenyloctyl) benzenepropanoic acid, zinc salt].",False,"Is the triple 'Ibuprofen disrupts Myalgia' supported by the sentence: 'In this limited pilot study, we compared the effect on clinical outcome of treating Pseudomonas keratitis in guinea pigs with prednisolone (a corticosteroid), flurbiprofen (a cyclo-oxygenase inhibitor), nordihydroguaiaretic acid (a lipoxygenase inhibitor), and a leukotriene antagonist, SKF104353 [R-(R*, S*)]-beta-[(2-carboxyethyl) thio-alpha-hydroxy-2-(8-phenyloctyl) benzenepropanoic acid, zinc salt].'?","No, this sentence does not indirectly support the statement ""Ibuprofen disrupts Myalgia."" The sentence is about a study on Pseudomonas keratitis in guinea pigs, where different treatments including flurbiprofen, a cyclo-oxygenase inhibitor like ibuprofen, were compared. However, it does not mention myalgia (muscle pain) or any disruption caused by ibuprofen, nor does it provide any correlation between ibuprofen use and muscle pain relief in this context." -18599970,Ibuprofen disrupts arthritic joint disease,151,URINARY EXCRETION OF PREDNISOLONE AFTER INTRARECTAL THERAPY IN ULCERATIVE COLITIS.,False,Is the triple 'Ibuprofen disrupts arthritic joint disease' supported by the sentence: 'URINARY EXCRETION OF PREDNISOLONE AFTER INTRARECTAL THERAPY IN ULCERATIVE COLITIS.'?,"No, this sentence does not provide any indirect support for the statement that Ibuprofen disrupts arthritic joint disease. The sentence you provided discusses urinary excretion of Prednisolone after intrarectal therapy in ulcerative colitis, which is unrelated to Ibuprofen or its effects on arthritis." -15072611,Ibuprofen disrupts Fever,152,"Male rats treated with either budesonide, prednisolone, or triamcinolone acetonide in drinking water for up to 104 weeks developed slightly increased incidences of basophilic foci, and significantly increased incidences of combined hepatocellular adenomas/carcinomas as compared to controls.",False,"Is the triple 'Ibuprofen disrupts Fever' supported by the sentence: 'Male rats treated with either budesonide, prednisolone, or triamcinolone acetonide in drinking water for up to 104 weeks developed slightly increased incidences of basophilic foci, and significantly increased incidences of combined hepatocellular adenomas/carcinomas as compared to controls.'?","No, this statement does not indirectly support the claim that Ibuprofen disrupts fever. The sentence provided discusses the effects of budesonide, prednisolone, and triamcinolone acetonide, which are all types of corticosteroids, on male rats. It does not mention Ibuprofen, which is a non-steroidal anti-inflammatory drug (NSAID) used for its analgesic, anti-pyretic, and anti-inflammatory effects. The sentence discusses increased incidences of basophilic foci and hepatocellular adenomas/carcinomas in rats, not fever disruption." -14486259,Ibuprofen disrupts Pain,153,[On the use of prednisolone in hemolytic anemia of the newborn caused by fetomaternal Rh-factor incompatibility].,False,Is the triple 'Ibuprofen disrupts Pain' supported by the sentence: '[On the use of prednisolone in hemolytic anemia of the newborn caused by fetomaternal Rh-factor incompatibility].'?,"No, this sentence does not provide any direct or indirect support for the statement ""Ibuprofen disrupts Pain."" The sentence is about the use of prednisolone in hemolytic anemia, which is not related to ibuprofen or pain disruption." -8331095,Ibuprofen disrupts Alzheimer disease,154,Long-term use of prednisone and prednisolone in juvenile rheumatoid arthritis; a report of fifteen cases.,False,Is the triple 'Ibuprofen disrupts Alzheimer disease' supported by the sentence: 'Long-term use of prednisone and prednisolone in juvenile rheumatoid arthritis; a report of fifteen cases.'?,"No, this sentence does not provide any direct or indirect support for the statement that Ibuprofen disrupts Alzheimer's disease. The sentence discusses the long-term use of prednisone and prednisolone in juvenile rheumatoid arthritis, but it does not mention Ibuprofen or Alzheimer's disease." -25657729,Ibuprofen prevents hypertensive disorder,155,[Effect of prednisolone and human albumin on protein excretion in nephrotic syndrome].,False,Is the triple 'Ibuprofen prevents hypertensive disorder' supported by the sentence: '[Effect of prednisolone and human albumin on protein excretion in nephrotic syndrome].'?,"No, this sentence does not provide any indirect support for the statement that Ibuprofen prevents hypertensive disorders in nephrotic syndrome patients. The sentence discusses the effect of prednisolone and human albumin on protein excretion in nephrotic syndrome, but it does not mention Ibuprofen or any related protective effects against hypertensive disorders." -22159382,Ibuprofen prevents Hemorrhage,156,[Therapeutic results of metacortandralone or prednisolone in allergy].,False,Is the triple 'Ibuprofen prevents Hemorrhage' supported by the sentence: '[Therapeutic results of metacortandralone or prednisolone in allergy].'?,"No, this sentence does not indirectly support the statement that Ibuprofen prevents hemorrhage. The sentence mentioned is about therapeutic results of metacortandralone or prednisolone in allergy, which is not related to Ibuprofen or hemorrhage prevention. Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) commonly used for relieving pain, reducing inflammation, and bringing down fever, not for preventing hemorrhage, and it is different from metacortandralone or prednisolone, which are steroid-based drugs used primarily for their anti-inflammatory effects in various conditions, including allergy." -22123299,Ibuprofen prevents Fever,157,Primary resistance to vincristine (Vcr) and prednisolone in untreated AML was observed as well as 'acquired' resistance to several other antileukemic drugs.,False,Is the triple 'Ibuprofen prevents Fever' supported by the sentence: 'Primary resistance to vincristine (Vcr) and prednisolone in untreated AML was observed as well as 'acquired' resistance to several other antileukemic drugs.'?,"No, this statement does not indirectly support the idea that Ibuprofen prevents fever in relation to vincristine (Vcr) and prednisolone resistance in acute myeloid leukemia (AML). The sentence discusses drug resistance in AML, specifically to vincristine, prednisolone, and several other antileukemic drugs, but it does not mention Ibuprofen or fever." -21354514,Ibuprofen prevents pancreatitis,158,"REPORT of the Committee on New Drugs of the Research Council of the American Academy of Allergy, 1955-56; studies on prednisone and prednisolone in ragweed pollinosis.",False,"Is the triple 'Ibuprofen prevents pancreatitis' supported by the sentence: 'REPORT of the Committee on New Drugs of the Research Council of the American Academy of Allergy, 1955-56; studies on prednisone and prednisolone in ragweed pollinosis.'?","No, this statement does not provide any indirect support for the claim that Ibuprofen prevents pancreatitis. The statement is about studies on prednisone and prednisolone in ragweed pollinosis, which is not related to Ibuprofen or pancreatitis." -20691057,Ibuprofen prevents altitude sickness,159,Effects of prednisone and prednisolone in ocular inflammation.,False,Is the triple 'Ibuprofen prevents altitude sickness' supported by the sentence: 'Effects of prednisone and prednisolone in ocular inflammation.'?,"No, this sentence does not provide any direct or indirect evidence to support the claim that Ibuprofen prevents altitude sickness. The sentence discusses the effects of prednisone and prednisolone in ocular inflammation, which is unrelated to Ibuprofen and altitude sickness." -19399624,Ibuprofen prevents osteoarthritis,160,"Prednisolone scored better than prednisone in the categories of texture, taste, and aftertaste (p < 0.05); there was no statistical difference in smell.",False,"Is the triple 'Ibuprofen prevents osteoarthritis' supported by the sentence: 'Prednisolone scored better than prednisone in the categories of texture, taste, and aftertaste (p < 0.05); there was no statistical difference in smell.'?","No, this sentence does not provide any support for the claim that Ibuprofen prevents osteoarthritis. The sentence is comparing two types of steroids, prednisolone and prednisone, in terms of their sensory attributes, which is not related to the preventive effects of Ibuprofen on osteoarthritis." -17687542,Ibuprofen prevents canker sore,161,Plasma prednisolone levels after administration of prednisolone-21-phosphate as a retention enema in colitis.,False,Is the triple 'Ibuprofen prevents canker sore' supported by the sentence: 'Plasma prednisolone levels after administration of prednisolone-21-phosphate as a retention enema in colitis.'?,"No, this statement does not indirectly support the claim that Ibuprofen prevents canker sores. The sentence discusses plasma prednisolone levels after administration of prednisolone-21-phosphate as a retention enema in colitis, which has no direct or indirect relation to Ibuprofen preventing canker sores." -15961024,Ibuprofen prevents Dysmenorrhea,162,Mizoribine as an effective combined maintenance therapy with prednisolone in child-onset systemic lupus erythematosus.,False,Is the triple 'Ibuprofen prevents Dysmenorrhea' supported by the sentence: 'Mizoribine as an effective combined maintenance therapy with prednisolone in child-onset systemic lupus erythematosus.'?,"No, this statement does not indirectly support the claim that Ibuprofen prevents Dysmenorrhea. The sentence discusses Mizoribine and Prednisolone as an effective combined maintenance therapy for child-onset systemic lupus erythematosus, which is unrelated to Ibuprofen's potential effects on dysmenorrhea (painful menstruation)." -13710734,Ibuprofen prevents Chronic pain,163,Controlled prospective trial of prednisolone and cytotoxics in progressive IgA nephropathy.,False,Is the triple 'Ibuprofen prevents Chronic pain' supported by the sentence: 'Controlled prospective trial of prednisolone and cytotoxics in progressive IgA nephropathy.'?,"No, this statement is not indirectly supported by the sentence provided. The sentence discusses a controlled prospective trial of prednisolone and cytotoxics in progressive IgA nephropathy, which is a type of kidney disease. Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) used for relieving pain, reducing inflammation, and bringing down fever, it is not directly related to the treatment or prevention of chronic pain in the context provided." -10201705,Ibuprofen prevents Headache,164,"We propose that FE(NO) is associated with eosinophilic inflammation in children with difficult asthma, following prednisolone, and may help in identifying patients in whom persistent symptoms are associated with airway eosinophilia.",False,"Is the triple 'Ibuprofen prevents Headache' supported by the sentence: 'We propose that FE(NO) is associated with eosinophilic inflammation in children with difficult asthma, following prednisolone, and may help in identifying patients in whom persistent symptoms are associated with airway eosinophilia.'?","No, this sentence does not indirectly support the statement that Ibuprofen prevents headaches in children, as it discusses the association between FE(NO) levels, eosinophilic inflammation, and asthma symptoms in children following prednisolone treatment, but does not mention Ibuprofen or headaches." -10026105,Ibuprofen prevents Myalgia,165,"Liposomal daunorubicin (DaunoXome) in combination with cyclophosphamide, vincristine and prednisolone (COP-X) as salvage therapy in poor-prognosis non-Hodgkins lymphoma.",False,"Is the triple 'Ibuprofen prevents Myalgia' supported by the sentence: 'Liposomal daunorubicin (DaunoXome) in combination with cyclophosphamide, vincristine and prednisolone (COP-X) as salvage therapy in poor-prognosis non-Hodgkins lymphoma.'?","No, this sentence does not provide any direct or indirect support for the statement ""Ibuprofen prevents Myalgia"". The two statements discuss different subjects, with one focusing on a specific cancer treatment regimen (Liposomal daunorubicin in combination with cyclophosphamide, vincristine, and prednisolone for non-Hodgkins lymphoma) while the other mentions Ibuprofen, an anti-inflammatory drug, and myalgia, muscle pain." -9104502,Ibuprofen prevents injury,166,Prednisolone in Duchenne muscular dystrophy.,False,Is the triple 'Ibuprofen prevents injury' supported by the sentence: 'Prednisolone in Duchenne muscular dystrophy.'?,"No, this sentence does not provide any direct or indirect support for the statement that Ibuprofen prevents injury. The sentence ""Prednisolone in Duchenne muscular dystrophy."" is about the use of Prednisolone, a corticosteroid, in treating Duchenne muscular dystrophy, a genetic disorder characterized by progressive muscle degeneration and weakness. It does not mention Ibuprofen or its preventative effects on injury." -9022792,Ibuprofen prevents Pain,167,Intravenous prednisolone in chronic bronchial asthma.,False,Is the triple 'Ibuprofen prevents Pain' supported by the sentence: 'Intravenous prednisolone in chronic bronchial asthma.'?,"No, this statement is not supported by the given sentence. The sentence mentions intravenous prednisolone, which is a corticosteroid used for treating chronic bronchial asthma, not ibuprofen, which is a non-steroidal anti-inflammatory drug used for pain relief, fever reduction, and inflammation reduction in conditions such as arthritis, menstrual cramps, headaches, toothaches, and common colds. The two statements discuss different medications used for different medical conditions, so there is no direct or indirect support for ibuprofen preventing pain in the given sentence about prednisolone use in chronic bronchial asthma." -8584177,Ibuprofen prevents patent ductus arteriosus,168,Reversibility with prednisolone is rarely seen in COPD.,False,Is the triple 'Ibuprofen prevents patent ductus arteriosus' supported by the sentence: 'Reversibility with prednisolone is rarely seen in COPD.'?,"No, this statement does not indirectly support the claim that Ibuprofen prevents patent ductus arteriosus in relation to COPD (Chronic Obstructive Pulmonary Disease). - - The sentence ""Reversibility with prednisolone is rarely seen in COPD"" is discussing the effects of prednisolone on COPD, not Ibuprofen or patent ductus arteriosus. Patent ductus arteriosus is a congenital heart defect, unrelated to COPD, which can be treated with Ibuprofen in some cases, but this sentence does not provide any information about that." -7843138,Ibuprofen prevents Alzheimer disease,169,"In spite of the fact that prednisolone-based treatment of pemphigus patients has proved to be effective in controlling the disease, some undesirable effects associated with this form of treatment have prompted investigation into other therapeutic approaches.",False,"Is the triple 'Ibuprofen prevents Alzheimer disease' supported by the sentence: 'In spite of the fact that prednisolone-based treatment of pemphigus patients has proved to be effective in controlling the disease, some undesirable effects associated with this form of treatment have prompted investigation into other therapeutic approaches.'?","No, this statement does not provide indirect support for the claim that Ibuprofen prevents Alzheimer's disease. The sentence discusses the use of prednisolone in treating pemphigus patients, its effectiveness, and the investigation into other therapeutic approaches due to undesirable effects. Ibuprofen is not mentioned, nor is there any connection made to Alzheimer's disease prevention." -15342704,Ibuprofen exacerbates injury,170,One reason for the good clinical effects of prednisolone in RA could be a down-regulation of adhesion and phagocytosis receptors on monocytes.,False,Is the triple 'Ibuprofen exacerbates injury' supported by the sentence: 'One reason for the good clinical effects of prednisolone in RA could be a down-regulation of adhesion and phagocytosis receptors on monocytes.'?,"No, this sentence does not indirectly support the statement that Ibuprofen exacerbates injury. The sentence discusses the clinical effects of prednisolone in Rheumatoid Arthritis (RA), which is not directly related to Ibuprofen or its potential to exacerbate injury. Prednisolone is an anti-inflammatory medication, and its mechanism of action involves down-regulation of adhesion and phagocytosis receptors on monocytes, which may contribute to its therapeutic effects in RA, but it does not provide any information about Ibuprofen or its impact on injury." -20007370,Ibuprofen predisposes cerebral palsy,171,OBJECTIVE: To appraise the adjunctive role of prednisolone (PN) in pulmonary tuberculosis (PTB) with toxic reactions.,False,Is the triple 'Ibuprofen predisposes cerebral palsy' supported by the sentence: 'OBJECTIVE: To appraise the adjunctive role of prednisolone (PN) in pulmonary tuberculosis (PTB) with toxic reactions.'?,"No, this statement does not provide any support for the idea that ibuprofen predisposes cerebral palsy, directly or indirectly. The objective statement discusses the role of prednisolone in pulmonary tuberculosis, not ibuprofen, nor cerebral palsy." -14332005,Ibuprofen predisposes bronchopulmonary dysplasia,172,"A significant reduction of survival was found with the presence of permanent visual loss vs absence (p = 0.04), in patients who required more than 10 mg/d of glucocorticoid (p < 0.001) at 6 months treatment and in patients treated with prednisone (vs prednisolone) (p < 0.01).",False,"Is the triple 'Ibuprofen predisposes bronchopulmonary dysplasia' supported by the sentence: 'A significant reduction of survival was found with the presence of permanent visual loss vs absence (p = 0.04), in patients who required more than 10 mg/d of glucocorticoid (p < 0.001) at 6 months treatment and in patients treated with prednisone (vs prednisolone) (p < 0.01).'?","No, this sentence does not provide any direct support for the statement ""Ibuprofen predisposes bronchopulmonary dysplasia"". This sentence is discussing the effects of glucocorticoid treatment, specifically in relation to survival rates, visual loss, and type of steroid used (prednisone vs prednisolone). Ibuprofen is not mentioned in this sentence, therefore it does not provide any indirect support either." -14294004,Ibuprofen predisposes Alzheimer disease,173,"Fourteen patients developed hyperglycemia during induction therapy of acute lymphoblastic leukemia with L-asparaginase, prednisolone, vincristine and daunorubicin.",False,"Is the triple 'Ibuprofen predisposes Alzheimer disease' supported by the sentence: 'Fourteen patients developed hyperglycemia during induction therapy of acute lymphoblastic leukemia with L-asparaginase, prednisolone, vincristine and daunorubicin.'?","No, this sentence does not provide any evidence to support the claim that Ibuprofen predisposes Alzheimer disease, directly or indirectly. The sentence discusses patients developing hyperglycemia during induction therapy for acute lymphoblastic leukemia, which does not relate to Ibuprofen or Alzheimer disease." -14085648,Ibuprofen predisposes injury,174,A 66-year-old man was treated for IgD (lambda) multiple myeloma with 2mg/day melphalan and 20mg/day prednisolone.,False,Is the triple 'Ibuprofen predisposes injury' supported by the sentence: 'A 66-year-old man was treated for IgD (lambda) multiple myeloma with 2mg/day melphalan and 20mg/day prednisolone.'?,"No, this sentence does not provide any support for the statement that Ibuprofen predisposes injury. The sentence discusses a patient being treated for multiple myeloma with melphalan and prednisolone, but it does not mention Ibuprofen or any related injuries." -12673407,Ibuprofen predisposes bone fracture,175,"Moreover, after recent findings regarding the presence of endogenous prednisolone in the urine of more popular breeds, particular attention was given to analysis of the presence of prednisolone and prednisone, as well.",False,"Is the triple 'Ibuprofen predisposes bone fracture' supported by the sentence: 'Moreover, after recent findings regarding the presence of endogenous prednisolone in the urine of more popular breeds, particular attention was given to analysis of the presence of prednisolone and prednisone, as well.'?","No, this sentence does not provide indirect support for the statement that Ibuprofen predisposes bone fractures. The sentence is discussing the presence of endogenous prednisolone in the urine of certain dog breeds, which is not related to Ibuprofen use or bone fractures." -17604344,Ivabradine related to diastolic heart failure,176,"Of 10 mg of prednisone given orally to 5 normal subjects, 69+/-5% was absorbed and converted to peripheral plasma prednisolone within 8 h.",False,"Is the triple 'Ivabradine related to diastolic heart failure' supported by the sentence: 'Of 10 mg of prednisone given orally to 5 normal subjects, 69+/-5% was absorbed and converted to peripheral plasma prednisolone within 8 h.'?","No, this sentence does not provide support for the statement that Ivabradine is indirectly related to diastolic heart failure. The sentence discusses the absorption and conversion of prednisone, not Ivabradine, in normal subjects. Therefore, it does not provide any relevant information about Ivabradine, its effects, or its potential relation to diastolic heart failure." -19228519,Ivabradine causes atrial fibrillation,177,"As in humans, prednisolone was partly converted to prednisone in the rabbit.",False,"Is the triple 'Ivabradine causes atrial fibrillation' supported by the sentence: 'As in humans, prednisolone was partly converted to prednisone in the rabbit.'?","No, this sentence does not provide any support for the claim that Ivabradine causes atrial fibrillation. The sentence is about prednisolone being converted to prednisone in rabbits, which has no direct or indirect relation to Ivabradine causing atrial fibrillation in humans." -20784958,Ivabradine affects atrial fibrillation,178,"Given the close resemblance of the ring A structure of prednisolone and prednisone on the one hand, and of androstadienedione on the other, the transformation of cortisol and cortisone into prednisolone and prednisone in cattle faeces was evaluated.",False,"Is the triple 'Ivabradine affects atrial fibrillation' supported by the sentence: 'Given the close resemblance of the ring A structure of prednisolone and prednisone on the one hand, and of androstadienedione on the other, the transformation of cortisol and cortisone into prednisolone and prednisone in cattle faeces was evaluated.'?","No, this sentence does not provide any indirect support for the statement ""Ivabradine affects atrial fibrillation"". The sentence discusses the transformation of cortisol and cortisone into prednisolone and prednisone in cattle faeces, which is not related to Ivabradine or atrial fibrillation." -20520107,Ivabradine affects mitral valve stenosis,179,The data indicate that prednisone is extensively metabolized to prednisolone before it clears the splanchnic circulation and the formation prednisone by oxidation of the 11-hydorxyl group of prednisolone appears to occur mainly in peripheral tissues.,False,Is the triple 'Ivabradine affects mitral valve stenosis' supported by the sentence: 'The data indicate that prednisone is extensively metabolized to prednisolone before it clears the splanchnic circulation and the formation prednisone by oxidation of the 11-hydorxyl group of prednisolone appears to occur mainly in peripheral tissues.'?,"No, this sentence does not provide any support for the claim that Ivabradine affects mitral valve stenosis, directly or indirectly. The sentence is about the metabolism of prednisone to prednisolone, primarily in peripheral tissues, not about Ivabradine or its effects on heart conditions like mitral valve stenosis." -20004006,Ivabradine affects diastolic heart failure,180,CONCLUSION: Dexamethasone or prednisolone were the easiest to induce steroid glaucoma when the patients had long-term use of steroid eyedrops.,False,Is the triple 'Ivabradine affects diastolic heart failure' supported by the sentence: 'CONCLUSION: Dexamethasone or prednisolone were the easiest to induce steroid glaucoma when the patients had long-term use of steroid eyedrops.'?,"No, this sentence does not provide any support for the statement that Ivabradine affects diastolic heart failure, directly or indirectly. The sentence discusses the effects of dexamethasone or prednisolone on steroid glaucoma, which is unrelated to Ivabradine and diastolic heart failure." -15323309,Ivabradine affects cardiovascular disorder,181,"Among 121 CK-analogs studied, CK-17, CK-101A and CK103A have been identified as promising anti-inflammatory agents as potent as prednisolone in inhibiting lens proteins-induced inflammation and twice as potent as prednisolone in inhibiting endotoxin-and IL-1-induced uveitis.",False,"Is the triple 'Ivabradine affects cardiovascular disorder' supported by the sentence: 'Among 121 CK-analogs studied, CK-17, CK-101A and CK103A have been identified as promising anti-inflammatory agents as potent as prednisolone in inhibiting lens proteins-induced inflammation and twice as potent as prednisolone in inhibiting endotoxin-and IL-1-induced uveitis.'?","No, this sentence does not provide any support for the idea that Ivabradine affects cardiovascular disorders, directly or indirectly. The sentence discusses the anti-inflammatory properties of certain CK-analogs, but it does not mention Ivabradine or any cardiovascular disorders." -15323306,Ivabradine affects coronary artery disorder,182,Light and electron microscopy of prednisolone-induced nephropathy in rabbits.,False,Is the triple 'Ivabradine affects coronary artery disorder' supported by the sentence: 'Light and electron microscopy of prednisolone-induced nephropathy in rabbits.'?,"No, this sentence does not provide any support for the claim that Ivabradine affects coronary artery disorder, directly or indirectly. The sentence discusses prednisolone-induced nephropathy in rabbits, which is not related to Ivabradine or coronary artery disorders." -19514713,Ivabradine disrupts atrial fibrillation,183,The behavior results showed that exposure to prednisolone resulted in decreased autonomic activity and low sensitivity to light.,False,Is the triple 'Ivabradine disrupts atrial fibrillation' supported by the sentence: 'The behavior results showed that exposure to prednisolone resulted in decreased autonomic activity and low sensitivity to light.'?,"No, this sentence does not indirectly support the statement that Ivabradine disrupts atrial fibrillation based on the information given about prednisolone, another drug, affecting autonomic activity and light sensitivity. The two statements involve different substances, conditions, and physiological effects, making it difficult to establish any indirect correlation between them without additional data linking Ivabradine, autonomic activity, light sensitivity, and atrial fibrillation." -17909104,Ivabradine disrupts coronary artery disorder,184,We therefore advocate for increased clinical alertness towards prednisolone-induced adrenal insufficiency in RTx patients and thus their potential need of rescue GC supplementation during stress.,False,Is the triple 'Ivabradine disrupts coronary artery disorder' supported by the sentence: 'We therefore advocate for increased clinical alertness towards prednisolone-induced adrenal insufficiency in RTx patients and thus their potential need of rescue GC supplementation during stress.'?,"No, this sentence does not provide any indirect support for the statement that Ivabradine disrupts coronary artery disorder. The sentence is discussing prednisolone-induced adrenal insufficiency in RTx patients and their potential need for rescue GC supplementation during stress, which is unrelated to Ivabradine and its effects on coronary artery disorder." -17822394,Ivabradine prevents atrial fibrillation,185,Zeaxanthin (50 mg/kg/day) or prednisolone (5 mg/kg/day) was orally administered for 14 days before induction of ulcerative colitis.,False,Is the triple 'Ivabradine prevents atrial fibrillation' supported by the sentence: 'Zeaxanthin (50 mg/kg/day) or prednisolone (5 mg/kg/day) was orally administered for 14 days before induction of ulcerative colitis.'?,"No, this sentence does not provide any support, direct or indirect, for the statement ""Ivabradine prevents atrial fibrillation."" The sentence discusses the oral administration of Zeaxanthin or prednisolone in relation to ulcerative colitis induction, which is unrelated to Ivabradine or atrial fibrillation." -10817471,Ivabradine prevents Tachycardia,186,"OBJECTIVE: We want to show that an intralesional injection of prednisolone into the proximal nail fold may produce dorsal pain, dyspnoea and headaches within the 2 min following the injection and to explain the pathophysiology of his condition.",False,"Is the triple 'Ivabradine prevents Tachycardia' supported by the sentence: 'OBJECTIVE: We want to show that an intralesional injection of prednisolone into the proximal nail fold may produce dorsal pain, dyspnoea and headaches within the 2 min following the injection and to explain the pathophysiology of his condition.'?","No, this statement does not support the claim that Ivabradine prevents tachycardia (a rapid heart rate) indirectly. The sentence mentions an objective about studying the effects of an intralesional injection of prednisolone into the proximal nail fold, which can cause symptoms like dorsal pain, dyspnoea (shortness of breath), and headaches within 2 minutes following the injection, but it does not mention Ivabradine, tachycardia, nor any connection between these topics." -19153602,Ivabradine predisposes atrial fibrillation,187,[A case of nephrotic syndrome with abnormally high level of protein C induced by prednisolone].,False,Is the triple 'Ivabradine predisposes atrial fibrillation' supported by the sentence: '[A case of nephrotic syndrome with abnormally high level of protein C induced by prednisolone].'?,"No, this sentence does not provide any support for the claim that Ivabradine predisposes to atrial fibrillation, directly or indirectly. The sentence discusses a case of nephrotic syndrome induced by prednisolone, which is unrelated to Ivabradine or atrial fibrillation." -15385004,Cefixime affects chronic bronchitis,188,It is concluded that six or more cycles of COPP chemotherapy for advanced Hodgkin's disease in men leads to permanent sterility.,False,Is the triple 'Cefixime affects chronic bronchitis' supported by the sentence: 'It is concluded that six or more cycles of COPP chemotherapy for advanced Hodgkin's disease in men leads to permanent sterility.'?,"No, this statement does not provide any indirect support for the idea that Cefixime affects chronic bronchitis. The sentence discusses the effects of COPP chemotherapy on fertility in men with Hodgkin's disease, which is not related to Cefixime or chronic bronchitis." -15252860,Cefixime affects gonorrhea,189,The erythroderma improved generally as a result of systemic prednisolone treatment.,False,Is the triple 'Cefixime affects gonorrhea' supported by the sentence: 'The erythroderma improved generally as a result of systemic prednisolone treatment.'?,"No, this statement does not provide any indirect support for the claim that Cefixime affects Gonorrhea. The sentence mentions the improvement of erythroderma due to systemic prednisolone treatment, but it does not mention Cefixime, Gonorrhea, or any connection between them." -18811968,Cefixime prevents otitis media,190,CONTACT DERMATITIS DUE TO TOPICAL HYDROCORTISONE AND PREDNISOLONE.,False,Is the triple 'Cefixime prevents otitis media' supported by the sentence: 'CONTACT DERMATITIS DUE TO TOPICAL HYDROCORTISONE AND PREDNISOLONE.'?,"No, this statement does not provide indirect support for the claim that Cefixime prevents otitis media based on the information given about contact dermatitis due to topical Hydrocortisone and Prednisolone. Contact dermatitis is a skin condition caused by an allergic reaction to substances like Hydrocortisone and Prednisolone, which are topical steroids used to reduce inflammation, whereas Cefixime is an antibiotic used to treat bacterial infections, including otitis media (an ear infection). The two statements discuss different medical conditions, treatments, and mechanisms, thus there is no implied correlation between them." -17748395,Trimetazidine related to diabetic kidney disease,191,[Pulmonary tuberculosis due to prednisolone].,False,Is the triple 'Trimetazidine related to diabetic kidney disease' supported by the sentence: '[Pulmonary tuberculosis due to prednisolone].'?,"No, this sentence does not provide any support for a relationship between Trimetazidine and diabetic kidney disease, directly or indirectly. The sentence mentions pulmonary tuberculosis as a side effect of prednisolone, but it does not mention Trimetazidine or any connection to diabetic kidney disease." -22426756,Trimetazidine affects diabetic kidney disease,192,"Rats were treated with a leukotriene synthesis inhibitor (PF-5901), a leukotriene B4 receptor antagonist (SC-41930), an IL-1 receptor antagonist or a corticosteroid (prednisolone) prior to induction of colitis.",False,"Is the triple 'Trimetazidine affects diabetic kidney disease' supported by the sentence: 'Rats were treated with a leukotriene synthesis inhibitor (PF-5901), a leukotriene B4 receptor antagonist (SC-41930), an IL-1 receptor antagonist or a corticosteroid (prednisolone) prior to induction of colitis.'?","No, this sentence does not provide direct support for the statement that Trimetazidine affects diabetic kidney disease. The sentence mentions various treatments given to rats before induction of colitis, but it does not mention Trimetazidine or any related compounds, nor does it mention diabetes or kidney disease." -21297588,Trimetazidine affects Cardiotoxicity,193,"PURPOSE: To investigate the relationship between vitamin E deficiency and prednisolone-induced cataract formation, long-term examination of lens changes was performed in rats under the condition of vitamin E deficiency or supplementation and administration of prednisolone.",False,"Is the triple 'Trimetazidine affects Cardiotoxicity' supported by the sentence: 'PURPOSE: To investigate the relationship between vitamin E deficiency and prednisolone-induced cataract formation, long-term examination of lens changes was performed in rats under the condition of vitamin E deficiency or supplementation and administration of prednisolone.'?","No, this sentence does not provide any support for the statement that Trimetazidine affects cardiotoxicity, directly or indirectly. The sentence is about an investigation into the relationship between vitamin E deficiency and prednisolone-induced cataract formation in rats, not about Trimetazidine or cardiotoxicity." -19164679,Trimetazidine affects cardiovascular disorder,194,"In inactive SLE induced by prednisolone therapy, the invariant Valpha24JalphaQ TCR could be detected in DN Valpha24+ T cells from all the patients and dominated in most of the patients.",False,"Is the triple 'Trimetazidine affects cardiovascular disorder' supported by the sentence: 'In inactive SLE induced by prednisolone therapy, the invariant Valpha24JalphaQ TCR could be detected in DN Valpha24+ T cells from all the patients and dominated in most of the patients.'?","No, this sentence does not provide support for the statement ""Trimetazidine affects cardiovascular disorder"". The sentence is discussing the presence of a specific T-cell receptor (TCR) in patients with inactive Systemic Lupus Erythematosus (SLE) who are undergoing prednisolone therapy. There is no connection made to Trimetazidine or any cardiovascular disorders in this sentence." -18547788,Trimetazidine prevents Cardiotoxicity,195,"Interleukin-1 (IL-1) blockers, CK 127 and CK 129, were found to inhibit IL-1-induced posterior uveitis very effectively at 3-10 mg/kg i.p. and were more potent than prednisolone which required at least 20 mg/kg i.p. to achieve the same level of anti-uveitis action.",False,"Is the triple 'Trimetazidine prevents Cardiotoxicity' supported by the sentence: 'Interleukin-1 (IL-1) blockers, CK 127 and CK 129, were found to inhibit IL-1-induced posterior uveitis very effectively at 3-10 mg/kg i.p. and were more potent than prednisolone which required at least 20 mg/kg i.p. to achieve the same level of anti-uveitis action.'?","No, this sentence does not provide any direct evidence to support the statement “Trimetazidine prevents cardiotoxicity.” The sentence discusses the effectiveness of interleukin-1 (IL-1) blockers in inhibiting IL-1-induced posterior uveitis in rats, which is an inflammatory condition in the eye, not cardiotoxicity. Trimetazidine is a drug primarily used to treat heart conditions, not to prevent cardiotoxicity, as far as current scientific knowledge goes. Therefore, there is no indirect support for Trimetazidine’s ability to prevent cardiotoxicity in this sentence." -13317799,Ranolazine causes atrial fibrillation,196,[A case of hormone-refractory prostate cancer responsive to low-dose prednisolone therapy].,False,Is the triple 'Ranolazine causes atrial fibrillation' supported by the sentence: '[A case of hormone-refractory prostate cancer responsive to low-dose prednisolone therapy].'?,"No, this sentence does not provide any support for the claim that Ranolazine causes atrial fibrillation. The sentence discusses a case of prostate cancer responding to low-dose prednisolone therapy, which is unrelated to Ranolazine or atrial fibrillation." -19314329,Ranolazine affects cardiovascular disorder,197,6 cases of FSGS had poor response to any therapy; 7 cases were responsive to either triple therapy or cyclosporine A plus prednisolone.,False,Is the triple 'Ranolazine affects cardiovascular disorder' supported by the sentence: '6 cases of FSGS had poor response to any therapy; 7 cases were responsive to either triple therapy or cyclosporine A plus prednisolone.'?,"No, this sentence does not provide support for the statement that Ranolazine affects cardiovascular disorders, directly or indirectly. The sentence discusses cases of Focal Segmental Glomerulosclerosis (FSGS) responding to certain therapies, one of which includes cyclosporine A plus prednisolone, but it does not mention Ranolazine. Therefore, it does not provide any evidence or support for its impact on cardiovascular disorders." -19002641,Ranolazine affects atrial fibrillation,198,"From 1983, exacerbation of PIE was recorded three times, on which occasions prednisolone and antibiotics were quite effective.",False,"Is the triple 'Ranolazine affects atrial fibrillation' supported by the sentence: 'From 1983, exacerbation of PIE was recorded three times, on which occasions prednisolone and antibiotics were quite effective.'?","No, this sentence does not provide any direct or indirect support for the statement that Ranolazine affects atrial fibrillation. The sentence discusses the exacerbation of PIE (Paroxysmal Intermittent Exotropia) and its treatment with prednisolone and antibiotics, but it does not mention Ranolazine or any related cardiovascular effects such as atrial fibrillation." -17881291,Ranolazine affects type 2 diabetes mellitus,199,"A comparative study of the effects of ACTH, hydrocortisone and prednisolone in the hypersensitive reactions produced with the protein components of Hymenolepis nana in albino mice.",False,"Is the triple 'Ranolazine affects type 2 diabetes mellitus' supported by the sentence: 'A comparative study of the effects of ACTH, hydrocortisone and prednisolone in the hypersensitive reactions produced with the protein components of Hymenolepis nana in albino mice.'?","No, this sentence does not provide any support for the statement that Ranolazine affects type 2 diabetes mellitus, directly or indirectly. The sentence discusses a comparative study on the effects of ACTH, hydrocortisone, and prednisolone in hypersensitive reactions produced by protein components of Hymenolepis nana in albino mice, which is unrelated to Ranolazine or its effects on type 2 diabetes mellitus." -16599546,Ranolazine affects atrial fibrillation,200,"Immunosuppressant therapy, such as prednisolone or azathioprine, is considered for exacerbations of highly active glomerulonephritis.",False,"Is the triple 'Ranolazine affects atrial fibrillation' supported by the sentence: 'Immunosuppressant therapy, such as prednisolone or azathioprine, is considered for exacerbations of highly active glomerulonephritis.'?","No, this sentence does not provide any indirect support for the statement that Ranolazine affects atrial fibrillation. The sentence discusses immunosuppressant therapy for glomerulonephritis, which is not related to Ranolazine or atrial fibrillation." -15199166,Ranolazine affects myocardial ischemia,201,"We describe a 57-year-old Caucasian male with anti-MDA5 positive dermatomyositis, that had a 4-month history of progressive dyspnoea requiring oxygen-therapy, scarcely responsive to prednisolone.",False,"Is the triple 'Ranolazine affects myocardial ischemia' supported by the sentence: 'We describe a 57-year-old Caucasian male with anti-MDA5 positive dermatomyositis, that had a 4-month history of progressive dyspnoea requiring oxygen-therapy, scarcely responsive to prednisolone.'?","No, this sentence does not provide any direct or indirect support for the statement ""Ranolazine affects myocardial ischemia."" The sentence describes a patient with dermatomyositis who has been on prednisolone therapy for four months, but it does not mention Ranolazine, myocardial ischemia, or any related concepts. Therefore, it does not contribute to the validation of the initial statement." -13887428,Ranolazine disrupts atrial fibrillation,202,"After 14 months of treatment one of the patients developed severe, acute exacerbation of the ABPA and was treated with high-dose prednisolone and local steroid.",False,"Is the triple 'Ranolazine disrupts atrial fibrillation' supported by the sentence: 'After 14 months of treatment one of the patients developed severe, acute exacerbation of the ABPA and was treated with high-dose prednisolone and local steroid.'?","No, this sentence does not provide indirect support for the statement ""Ranolazine disrupts atrial fibrillation"". The sentence discusses a patient with allergic bronchopulmonary aspergillosis (ABPA) who experienced an exacerbation and was treated with steroids, but it does not mention ranolazine or any effect on atrial fibrillation." -17475563,Ranolazine prevents Angina pectoris,203,"The effect of pretreatment with topical prostaglandin E2, prednisolone and sulphasalazine in experimental colitis has been examined in the rat colon.",False,"Is the triple 'Ranolazine prevents Angina pectoris' supported by the sentence: 'The effect of pretreatment with topical prostaglandin E2, prednisolone and sulphasalazine in experimental colitis has been examined in the rat colon.'?","No, this sentence does not provide any support, direct or indirect, for the statement ""Ranolazine prevents Angina Pectoris"". The sentence discusses the effects of three different substances (prostaglandin E2, prednisolone, and sulphasalazine) in an experimental colitis model in rats, which is unrelated to the therapeutic effects of Ranolazine on angina pectoris in humans." -14751648,Ranolazine prevents myocardial ischemia,204,"Here, we report a case of prednisolone-dependent gastric sarcoidosis that improved after additional azathioprine, and also review the literature concerning the treatment, especially for prednisolone-dependent cases.",False,"Is the triple 'Ranolazine prevents myocardial ischemia' supported by the sentence: 'Here, we report a case of prednisolone-dependent gastric sarcoidosis that improved after additional azathioprine, and also review the literature concerning the treatment, especially for prednisolone-dependent cases.'?","No, this sentence does not provide support for the statement ""Ranolazine prevents myocardial ischemia"". The sentence discusses a case of gastric sarcoidosis that improved after additional azathioprine treatment, and it also reviews literature about treatment, particularly for prednisolone-dependent cases. It does not mention ranolazine, myocardial ischemia, or any connection between them, so it does not provide any indirect support for the statement either." -14280230,Ranolazine prevents atrial fibrillation,205,"METHODS: In 126 adults (33 healthy control subjects, 31 patients with mild asthma, 32 patients with severe asthma, and 30 patients with prednisolone-dependent asthma) parameters of inflammation (peripheral blood eosinophils and neutrophils) and markers of hemostasis (endogenous thrombin potential [ETP], thrombin-antithrombin complex, plasmin-alpha2-antiplasmin complex, plasminogen activator inhibitor type 1 [PAI-1], D-dimer, and von Willebrand factor [vWF]) were measured in plasma.",False,"Is the triple 'Ranolazine prevents atrial fibrillation' supported by the sentence: 'METHODS: In 126 adults (33 healthy control subjects, 31 patients with mild asthma, 32 patients with severe asthma, and 30 patients with prednisolone-dependent asthma) parameters of inflammation (peripheral blood eosinophils and neutrophils) and markers of hemostasis (endogenous thrombin potential [ETP], thrombin-antithrombin complex, plasmin-alpha2-antiplasmin complex, plasminogen activator inhibitor type 1 [PAI-1], D-dimer, and von Willebrand factor [vWF]) were measured in plasma.'?","No, this sentence does not provide any support for the statement that Ranolazine prevents atrial fibrillation, directly or indirectly. This sentence describes the methods used in a study, detailing how inflammation parameters and markers of hemostasis were measured in plasma from different patient groups, including healthy controls, patients with different severities of asthma, and patients on prednisolone-dependent asthma treatment. There is no mention of Ranolazine, its effects, or any potential link to preventing atrial fibrillation in this sentence." -17988674,Ranolazine predisposes atrial fibrillation,206,Previous studies from our laboratory revealed that coadministration of EP significantly increased the plasma concentration of prednisolone while decreased the level of cotreated prednisone in rats.,False,Is the triple 'Ranolazine predisposes atrial fibrillation' supported by the sentence: 'Previous studies from our laboratory revealed that coadministration of EP significantly increased the plasma concentration of prednisolone while decreased the level of cotreated prednisone in rats.'?,"No, this sentence does not support the claim that Ranolazine predisposes atrial fibrillation, either directly or indirectly. The sentence discusses the effects of coadministration of EP on plasma concentration of prednisolone and prednisone in rats, which is unrelated to Ranolazine or atrial fibrillation." -26862829,Prednisolone related to multiple sclerosis,207,Metabolic effects of high-dose prednisolone treatment in early rheumatoid arthritis: balance between diabetogenic effects and inflammation reduction.,False,Is the triple 'Prednisolone related to multiple sclerosis' supported by the sentence: 'Metabolic effects of high-dose prednisolone treatment in early rheumatoid arthritis: balance between diabetogenic effects and inflammation reduction.'?,"No, this sentence does not indirectly support the claim that Prednisolone is related to multiple sclerosis (MS). The sentence discusses the metabolic effects of high-dose Prednisolone treatment in early rheumatoid arthritis, mentioning both diabetogenic effects (which could imply a connection to diabetes) and inflammation reduction. Multiple sclerosis is an autoimmune disease affecting the central nervous system, and while glucocorticoids like Prednisolone have been used in its treatment, this sentence does not provide evidence for such a connection." -26365803,Prednisolone related to adrenocortical insufficiency,208,"Effects of prednisolone, salbutamol and theophylline on bronchial hyperreactivity and leucocyte chemokinesis in guinea pigs.",False,"Is the triple 'Prednisolone related to adrenocortical insufficiency' supported by the sentence: 'Effects of prednisolone, salbutamol and theophylline on bronchial hyperreactivity and leucocyte chemokinesis in guinea pigs.'?","No, this statement does not provide support for the relationship between Prednisolone and adrenocortical insufficiency. Prednisolone is a synthetic glucocorticoid often used in medicine for its anti-inflammatory effects, while adrenocortical insufficiency refers to the inability of the adrenal glands to produce sufficient amounts of steroid hormones, including cortisol. The sentence in question discusses the effects of Prednisolone, Salbutamol, and Theophylline on bronchial hyperreactivity and leucocyte chemokinesis in guinea pigs, which does not pertain to adrenocortical insufficiency." -26295217,Prednisolone related to angioimmunoblastic T-cell lymphoma,209,"This is the first case to support the beneficial effect of prednisolone in pericarditis with pSS, and illustrates its safety during pregnancy.",False,"Is the triple 'Prednisolone related to angioimmunoblastic T-cell lymphoma' supported by the sentence: 'This is the first case to support the beneficial effect of prednisolone in pericarditis with pSS, and illustrates its safety during pregnancy.'?","No, this sentence does not provide support for a relationship between Prednisolone and angioimmunoblastic T-cell lymphoma. The sentence only discusses the beneficial effect and safety of Prednisolone in pericarditis with primary Sjogren's syndrome (pSS) during pregnancy. Angioimmunoblastic T-cell lymphoma is a distinct medical condition and this sentence does not mention nor imply any connection to it." -26194122,Prednisolone related to synovitis,210,"When combined with environmental control, prednisolone and dexamethasone treatments had similar effects on heaves score, blood gases and endoscopic scores.",True,"Is the triple 'Prednisolone related to synovitis' supported by the sentence: 'When combined with environmental control, prednisolone and dexamethasone treatments had similar effects on heaves score, blood gases and endoscopic scores.'?","Yes, this sentence does provide indirect support for the idea that Prednisolone is related to synovitis in horses, as heaves (also known as recurrent airway obstruction) in horses is often associated with inflammation in the airways, which can be linked to synovitis in other species such as humans (though not directly stated, it is implied). The fact that Prednisolone, which is a glucocorticoid used for its anti-inflammatory properties, has similar effects on heaves score, blood gases, and endoscopic scores as Dexamethasone suggests both drugs may have comparable effects on inflammation in horses, including potential involvement in controlling inflammation in synovial tissues if present in these animals. However, further research would be required for more definitive conclusions regarding Prednisolone’s specific relationship to equine synovitis." -25959730,Prednisolone related to sarcoma,211,"Of the 20 patients, 14 initially received prednisolone treatment, which resulted in rapid improvement and normalization of eosinophilia within 8 weeks; however, 2 patients with splenomegaly showed poor control of eosinophilia in response to corticosteroid treatment.",False,"Is the triple 'Prednisolone related to sarcoma' supported by the sentence: 'Of the 20 patients, 14 initially received prednisolone treatment, which resulted in rapid improvement and normalization of eosinophilia within 8 weeks; however, 2 patients with splenomegaly showed poor control of eosinophilia in response to corticosteroid treatment.'?","No, this sentence does not support a direct relationship between prednisolone and sarcoma. The sentence describes the effect of prednisolone on eosinophilia in 14 out of 20 patients, but it does not mention anything about sarcoma. Therefore, we cannot infer any indirect relationship between prednisolone and sarcoma from this sentence alone." -25621708,Prednisolone related to uveitis,212,Complement activation capacity in plasma before and during high-dose prednisolone treatment and tapering in exacerbations of Crohn's disease and ulcerative colitis.,True,Is the triple 'Prednisolone related to uveitis' supported by the sentence: 'Complement activation capacity in plasma before and during high-dose prednisolone treatment and tapering in exacerbations of Crohn's disease and ulcerative colitis.'?,"Yes, there is indirect support for the triple ""Prednisolone is related to uveitis"" based on the sentence provided, although it is not explicitly stated. The sentence discusses prednisolone treatment for Crohn’s disease and ulcerative colitis, which are conditions associated with uveitis, an inflammation of the eye often linked to autoimmune diseases like these two conditions. Therefore, prednisolone treatment could potentially influence uveitis through its impact on these diseases, but it is not directly stated in this sentence." -24523226,Prednisolone related to glomerulonephritis,213,Prednisolone-responsive headache in patients with solitary cysticercus granuloma and seizures.,False,Is the triple 'Prednisolone related to glomerulonephritis' supported by the sentence: 'Prednisolone-responsive headache in patients with solitary cysticercus granuloma and seizures.'?,"No, this sentence does not provide support for the relationship between Prednisolone and glomerulonephritis. Glomerulonephritis is a kidney disease, while the sentence discusses Prednisolone being used for headaches in patients with solitary cysticercus granuloma, which is a type of parasitic infection in the brain, and seizures." -23496152,Prednisolone related to subacute thyroiditis,214,"The patient was treated with chemotherapy by cyclophosphamide, hydroxydoxorubicin, vincristine and prednisolone (CHOP), however, it was ineffective, and the patient died of hemorrhage from the lymphoma involvement of the intestine 5 months after the onset of disease.",True,"Is the triple 'Prednisolone related to subacute thyroiditis' supported by the sentence: 'The patient was treated with chemotherapy by cyclophosphamide, hydroxydoxorubicin, vincristine and prednisolone (CHOP), however, it was ineffective, and the patient died of hemorrhage from the lymphoma involvement of the intestine 5 months after the onset of disease.'?","Yes, there is indirect support for the connection between Prednisolone and subacute thyroiditis in this sentence, although Prednisolone is not directly linked to subacute thyroiditis in this context. Prednisolone is an anti-inflammatory drug often used in treating various conditions, including autoimmune disorders, which could be relevant for thyroiditis. The fact that it was ineffective in treating this patient suggests it was not used for treating thyroiditis in this case, but rather as part of chemotherapy for lymphoma. However, this does not rule out the possibility that Prednisolone could be used in treating subacute thyroiditis in other contexts, hence the indirect support for the connection." -22194722,Prednisolone related to pulmonary eosinophilia,215,Effect of prednisolone in the experimentally induced nephropathy in male albino rats.,False,Is the triple 'Prednisolone related to pulmonary eosinophilia' supported by the sentence: 'Effect of prednisolone in the experimentally induced nephropathy in male albino rats.'?,"No, the sentence does not support a direct or indirect relationship between Prednisolone and pulmonary eosinophilia. The sentence discusses the effect of Prednisolone in experimentally induced nephropathy in male albino rats, which is unrelated to pulmonary eosinophilia." -21911849,Prednisolone related to habitual spontaneous abortion,216,[On the effect of oral use of prednisolone on central chorioretinitis].,False,Is the triple 'Prednisolone related to habitual spontaneous abortion' supported by the sentence: '[On the effect of oral use of prednisolone on central chorioretinitis].'?,"No, this sentence does not provide any support for a relationship between Prednisolone and habitual spontaneous abortion. The sentence discusses the effect of oral Prednisolone on central chorioretinitis, which is an eye condition, not pregnancy-related issues such as spontaneous abortion." -20512112,Prednisolone related to castration-resistant prostate carcinoma,217,Peptic ulceration associated with prednisolone therapy.,False,Is the triple 'Prednisolone related to castration-resistant prostate carcinoma' supported by the sentence: 'Peptic ulceration associated with prednisolone therapy.'?,"No, this sentence does not provide any indirect evidence supporting a relationship between Prednisolone and castration-resistant prostate carcinoma. The sentence only mentions an association between prednisolone therapy and peptic ulceration, which is not relevant to the topic at hand." -20312000,Prednisolone related to chronic primary adrenal insufficiency,218,"Glucocorticoids (e.g. prednisolone) are cornerstones in the treatment of acute exacerbations of ulcerative colitis (UC), and influence of the leucocyte/endothelial interaction appears to be part of their mode of action.",True,"Is the triple 'Prednisolone related to chronic primary adrenal insufficiency' supported by the sentence: 'Glucocorticoids (e.g. prednisolone) are cornerstones in the treatment of acute exacerbations of ulcerative colitis (UC), and influence of the leucocyte/endothelial interaction appears to be part of their mode of action.'?","Yes, there is indirect support for the connection between Prednisolone and chronic primary adrenal insufficiency in this sentence. Prednisolone is a type of glucocorticoid, which is used in the treatment of acute exacerbations of ulcerative colitis (UC). The mode of action for glucocorticoids in this context appears to involve influencing the leucocyte/endothelial interaction. - - Chronic primary adrenal insufficiency, also known as Addison's disease, is characterized by insufficient production of glucocorticoids (like prednisolone) from the adrenal glands. Therefore, while this sentence does not directly mention chronic primary adrenal insufficiency, it does provide context for how glucocorticoids like prednisolone function in the body, which is relevant to understanding their role in diseases like Addison's disease." -20106181,Prednisolone related to allergic bronchopulmonary aspergillosis,219,"Effects of honey, prednisolone, and disulfiram on inflammation, nitric oxide, and free radical formation.",True,"Is the triple 'Prednisolone related to allergic bronchopulmonary aspergillosis' supported by the sentence: 'Effects of honey, prednisolone, and disulfiram on inflammation, nitric oxide, and free radical formation.'?","Yes, there is indirect support for the connection between Prednisolone and allergic bronchopulmonary aspergillosis in this sentence, but only through inference based on contextual knowledge about these terms, not through direct mention in the sentence itself. Prednisolone is an anti-inflammatory drug often used in treating various conditions, including some respiratory disorders, while allergic bronchopulmonary aspergillosis is an inflammatory respiratory disease caused by an immune response against Aspergillus fungi, which can lead to inflammation, nitric oxide, and free radical formation in lungs. The sentence discusses the effects of Prednisolone on inflammation, nitric oxide, and free radical formation, which is indirectly relevant to allergic bronchopulmonary aspergillosis, as these factors play an essential role in this disease progression. However, this sentence does not explicitly confirm Prednisolone's use in treating allergic bronchopulmonary aspergillosis, so it is crucial not to overstate this connection without additional evidence from other sources." -19750187,Prednisolone related to lymphoma,220,OBJECTIVE: To assess the treatment effect of sodium hyaluronate (HA) on experimental temporomandibular joint (TMJ) osteoarthritis of rabbits in comparison with prednisolone (PS).,False,Is the triple 'Prednisolone related to lymphoma' supported by the sentence: 'OBJECTIVE: To assess the treatment effect of sodium hyaluronate (HA) on experimental temporomandibular joint (TMJ) osteoarthritis of rabbits in comparison with prednisolone (PS).'?,"No, this sentence does not provide any direct or indirect support for the statement that Prednisolone is related to lymphoma. The sentence only mentions Prednisolone in relation to its use in treating experimental temporomandibular joint (TMJ) osteoarthritis in rabbits, in comparison with sodium hyaluronate (HA). It does not mention or imply any connection between Prednisolone and lymphoma." -17143213,Prednisolone related to temporal arteritis,221,"ETO+PSL combination treatment, however, failed to show significant enhancement of anti-tumor effects.",False,"Is the triple 'Prednisolone related to temporal arteritis' supported by the sentence: 'ETO+PSL combination treatment, however, failed to show significant enhancement of anti-tumor effects.'?","No, it is not supported. The sentence mentions the failure of an ETO+PSL (Etoposide and Prednisolone) combination treatment in enhancing anti-tumor effects, but it does not provide any information about Prednisolone being indirectly related to temporal arteritis. Temporal arteritis is an inflammation in the lining of your arteries, while Prednisolone is a corticosteroid medication used for various conditions, including inflammation, allergies, and autoimmune disorders, but not specifically mentioned in relation to temporal arteritis in this sentence." -16983852,Prednisolone related to Hodgkins lymphoma,222,"My- and My+ ALL did not significantly differ in sensitivity to prednisolone, dexamethasone, L-asparaginase and cytarabine.",False,"Is the triple 'Prednisolone related to Hodgkins lymphoma' supported by the sentence: 'My- and My+ ALL did not significantly differ in sensitivity to prednisolone, dexamethasone, L-asparaginase and cytarabine.'?","No, this sentence does not provide any support for a relationship between Prednisolone and Hodgkin Lymphoma. The sentence discusses the sensitivity of My- and My+ Acute Lymphoblastic Leukemia (ALL) to several drugs, including Prednisolone, but it does not mention Hodgkin Lymphoma. Therefore, it does not provide any indirect evidence for a connection between Prednisolone and Hodgkin Lymphoma." -16960031,Prednisolone related to psoriatic arthritis,223,"The dose of prednisolone was increased considering he was exacerbated of SLE, however, the convulsion as CNS lupus occurred to him.",False,"Is the triple 'Prednisolone related to psoriatic arthritis' supported by the sentence: 'The dose of prednisolone was increased considering he was exacerbated of SLE, however, the convulsion as CNS lupus occurred to him.'?","No, this sentence does not provide indirect evidence supporting a relationship between Prednisolone and psoriatic arthritis. The sentence mentions Prednisolone being used in relation to Systemic Lupus Erythematosus (SLE) and the occurrence of convulsions as a result of Central Nervous System lupus, but it does not mention anything about psoriatic arthritis." -16502712,Prednisolone related to aplastic anemia,224,"In a pilot study using one rabbit, prednisone and prednisolone clearance values increased with increase in either prednisone or prednisolone infusion rates.",False,"Is the triple 'Prednisolone related to aplastic anemia' supported by the sentence: 'In a pilot study using one rabbit, prednisone and prednisolone clearance values increased with increase in either prednisone or prednisolone infusion rates.'?","No, this sentence does not provide support for a relationship between Prednisolone and aplastic anemia. The sentence discusses prednisone and prednisolone clearance values in rabbits, which is not directly relevant to aplastic anemia in humans. Aplastic anemia is a condition characterized by a failure of the bone marrow to produce blood cells, while Prednisolone is a corticosteroid medication often used to treat various conditions such as inflammation, allergies, and autoimmune disorders. While Prednisolone may have side effects that affect blood cells, this sentence does not provide evidence for such a relationship." -16371065,Prednisolone related to celiac disease,225,"Budesonide is equal to less effective than prednisolone or prednisone therapy in the treatment of active Crohn's disease, but is associated with fewer glucocorticoids adverse reactions.",False,"Is the triple 'Prednisolone related to celiac disease' supported by the sentence: 'Budesonide is equal to less effective than prednisolone or prednisone therapy in the treatment of active Crohn's disease, but is associated with fewer glucocorticoids adverse reactions.'?","No, this sentence does not provide support for a relationship between Prednisolone and celiac disease. The sentence discusses the use of Budesonide, Prednisolone, and Prednisone in treating Crohn's disease, not celiac disease. Furthermore, it only compares their effectiveness and side effects, not their direct relationship." -16192798,Prednisolone related to dermatomyositis,226,Diclofenac and prednisolone inhibit endotoxin-induced uveitis in rabbits.,False,Is the triple 'Prednisolone related to dermatomyositis' supported by the sentence: 'Diclofenac and prednisolone inhibit endotoxin-induced uveitis in rabbits.'?,"No, this sentence does not provide support for the relationship between Prednisolone and Dermatomyositis. The sentence only mentions that Diclofenac and Prednisolone inhibit endotoxin-induced uveitis in rabbits, it does not mention anything about Dermatomyositis." -16169223,Prednisolone related to mucocutaneous lymph node syndrome,227,"Although prednisolone and GH reverse hypoglycemia by different mechanisms, with only prednisolone suppressing tumor IGF-II secretion, both increase the formation of ternary IGF-IGFBP-3 complexes.",False,"Is the triple 'Prednisolone related to mucocutaneous lymph node syndrome' supported by the sentence: 'Although prednisolone and GH reverse hypoglycemia by different mechanisms, with only prednisolone suppressing tumor IGF-II secretion, both increase the formation of ternary IGF-IGFBP-3 complexes.'?","No, this sentence does not provide support for a direct or indirect relationship between Prednisolone and mucocutaneous lymph node syndrome. The sentence discusses the mechanisms of Prednisolone in relation to hypoglycemia, tumor IGF-II secretion, and IGF-IGFBP-3 complex formation, but it does not mention nor imply any connection to mucocutaneous lymph node syndrome." -16114172,Prednisolone related to plasma cell myeloma,228,"The aqueous extract of Saiboku-to also showed an inhibition of the contact dermatitis, and it significantly potentiated the inhibition of contact dermatitis by prednisolone.",False,"Is the triple 'Prednisolone related to plasma cell myeloma' supported by the sentence: 'The aqueous extract of Saiboku-to also showed an inhibition of the contact dermatitis, and it significantly potentiated the inhibition of contact dermatitis by prednisolone.'?","No, this sentence does not provide evidence for a direct relationship between Prednisolone and plasma cell myeloma. The sentence mentions an inhibition of contact dermatitis, which is not directly linked to plasma cell myeloma, a type of cancer. Prednisolone is an anti-inflammatory drug often used in cancer treatments, but this sentence does not provide specific evidence for its use in treating plasma cell myeloma." -14564343,Prednisolone related to acute lymphoblastic leukemia,229,Only hydrocortisone and prednisolone suppressed LPS pneumonia.,False,Is the triple 'Prednisolone related to acute lymphoblastic leukemia' supported by the sentence: 'Only hydrocortisone and prednisolone suppressed LPS pneumonia.'?,"No, this sentence does not provide evidence for a relationship between Prednisolone and acute lymphoblastic leukemia. The sentence only states that Prednisolone, along with Hydrocortisone, has an effect on LPS pneumonia. It does not imply any connection to acute lymphoblastic leukemia." -13988965,Prednisolone related to osteoarthritis,230,"Prednisolone significantly inhibited the measurable sensitivity of IDT, while oclacitinib did not.",False,"Is the triple 'Prednisolone related to osteoarthritis' supported by the sentence: 'Prednisolone significantly inhibited the measurable sensitivity of IDT, while oclacitinib did not.'?","No, this sentence does not provide evidence for a direct or indirect relationship between Prednisolone and osteoarthritis. The sentence only states that Prednisolone inhibited sensitivity in IDT, while Oclacitinib did not. It does not mention osteoarthritis at all." -13151963,Prednisolone related to diffuse large B-cell lymphoma,231,"A comparison with the bronchodilator potency of the above drugs indicated that in guinea pigs salbutamol appears relatively selective as a bronchodilator, prednisolone is selective as an inhibitor of eosinophilia whilst theophylline displays a balance of both activities.",False,"Is the triple 'Prednisolone related to diffuse large B-cell lymphoma' supported by the sentence: 'A comparison with the bronchodilator potency of the above drugs indicated that in guinea pigs salbutamol appears relatively selective as a bronchodilator, prednisolone is selective as an inhibitor of eosinophilia whilst theophylline displays a balance of both activities.'?","No, this sentence does not provide any indirect support for a relationship between Prednisolone and diffuse large B-cell lymphoma. The sentence discusses the effects of Prednisolone as an inhibitor of eosinophilia in guinea pigs, not its relationship with any specific diseases such as diffuse large B-cell lymphoma in humans." -13151962,Prednisolone related to follicular lymphoma,232,Reduction of maintenance doses of prednisolone in bronchial asthma by the concurrent use of hydroxyzine.,False,Is the triple 'Prednisolone related to follicular lymphoma' supported by the sentence: 'Reduction of maintenance doses of prednisolone in bronchial asthma by the concurrent use of hydroxyzine.'?,"No, this sentence does not provide any indirect support for the relationship between Prednisolone and follicular lymphoma. The sentence discusses the reduction of maintenance doses of prednisolone in bronchial asthma when used in conjunction with hydroxyzine, but it does not mention or imply any connection to follicular lymphoma." -12983495,Prednisolone related to prostate cancer,233,"In contrast, cyclosporin A (CyA), FK-506 and prednisolone significantly inhibited antigen-induced airway inflammation and BHR in sensitized BN rats.",False,"Is the triple 'Prednisolone related to prostate cancer' supported by the sentence: 'In contrast, cyclosporin A (CyA), FK-506 and prednisolone significantly inhibited antigen-induced airway inflammation and BHR in sensitized BN rats.'?","No, this sentence does not provide any support for a relationship between Prednisolone and prostate cancer. The sentence only mentions Prednisolone in relation to its inhibition of antigen-induced airway inflammation and bronchial hyperresponsiveness (BHR) in sensitized BN rats, not its relation to prostate cancer." -12510603,Prednisolone related to membranous glomerulonephritis,234,[Use of corticosteroids betamethasone and prednisolone in the prevention of allergic reactions in patients undergoing heart surgery with artificial blood circulation].,False,Is the triple 'Prednisolone related to membranous glomerulonephritis' supported by the sentence: '[Use of corticosteroids betamethasone and prednisolone in the prevention of allergic reactions in patients undergoing heart surgery with artificial blood circulation].'?,"No, I would not say there is direct support for the relationship between Prednisolone and membranous glomerulonephritis in this sentence. The sentence discusses the use of corticosteroids, specifically betamethasone and prednisolone, in preventing allergic reactions in heart surgery patients, but it does not mention or imply any connection to membranous glomerulonephritis, which is a specific type of kidney disease involving inflammation of the glomeruli, often associated with autoimmune disorders or other conditions like diabetes, hepatitis B, etc." -12496746,Prednisolone related to neoplasm,235,The intra-articular injection of prednisolone was shown to considerably reduce incidence of synovitis.,False,Is the triple 'Prednisolone related to neoplasm' supported by the sentence: 'The intra-articular injection of prednisolone was shown to considerably reduce incidence of synovitis.'?,"No, the sentence does not provide any support for a relationship between Prednisolone and neoplasm (abnormal tissue growth, often cancerous). The sentence only mentions that intra-articular injection of Prednisolone reduces the incidence of synovitis, which is inflammation of the synovial membrane, usually in joints." -12428137,Prednisolone related to croup,236,"Prednisolone (100 mg/die initially, decreasing doses thereafter) led to significant reduction of infiltrates and eosinophilia.",True,"Is the triple 'Prednisolone related to croup' supported by the sentence: 'Prednisolone (100 mg/die initially, decreasing doses thereafter) led to significant reduction of infiltrates and eosinophilia.'?","Yes, the sentence does provide indirect support for the idea that Prednisolone is related to croup, which is often characterized by infiltrates and eosinophilia in the respiratory system. Prednisolone is a corticosteroid medication often used in treating inflammatory conditions, including croup, due to its ability to reduce inflammation, as indicated by the reduction in infiltrates and eosinophilia in this sentence. However, it does not directly state that Prednisolone is used for treating croup, hence it is indirect evidence only." -12061894,Prednisolone related to West syndrome,237,The tumour was significantly reduced by prednisolone.,True,Is the triple 'Prednisolone related to West syndrome' supported by the sentence: 'The tumour was significantly reduced by prednisolone.'?,"Yes, the statement ""The tumour was significantly reduced by prednisolone."" can indirectly support the connection between Prednisolone and West Syndrome, as Prednisolone is often used as a treatment for various neurological disorders, including some forms of epilepsy, which is a primary symptom of West Syndrome. However, it does not directly confirm Prednisolone as a treatment for West Syndrome, as it only states that it reduced a tumour, which may not be directly linked to West Syndrome itself but rather a symptom or complication associated with it." -11663099,Prednisolone related to Crohn disease,238,"Prednisolone prevented the development of colitis, but had no effect on already-developed colitis.",True,"Is the triple 'Prednisolone related to Crohn disease' supported by the sentence: 'Prednisolone prevented the development of colitis, but had no effect on already-developed colitis.'?","Yes, this sentence does provide some indirect support for a connection between Prednisolone and Crohn disease, which is characterized in part by colitis (inflammation of the colon). The statement suggests that Prednisolone can prevent the development of colitis, implying it might have some protective effect against the conditions that lead to colitis, such as Crohn disease. However, it also indicates that Prednisolone does not affect already-developed colitis, which could suggest that it may not be as effective once the disease has progressed to this stage. This is only indirect evidence, as it does not directly state that Prednisolone is used for or is effective against Crohn disease, but it does suggest some sort of relationship between the two." -11638013,Prednisolone related to eosinophilic granulomatosis with polyangiitis,239,Alveolar NO concentration was increased in patients with refractory asthma (7.1 ppb) compared with mild-to-moderate asthma (3.4 ppb) and normal controls (3.4 ppb) and reduced by treatment with prednisolone.,True,Is the triple 'Prednisolone related to eosinophilic granulomatosis with polyangiitis' supported by the sentence: 'Alveolar NO concentration was increased in patients with refractory asthma (7.1 ppb) compared with mild-to-moderate asthma (3.4 ppb) and normal controls (3.4 ppb) and reduced by treatment with prednisolone.'?,"Yes, there is indirect support for a relationship between Prednisolone and eosinophilic granulomatosis with polyangiitis (EGPA) in this sentence. EGPA is often associated with severe asthma, which is characterized by increased alveolar nitric oxide (NO) concentrations. Prednisolone is a corticosteroid used in treating severe asthma, including EGPA, and it reduces alveolar NO concentrations, as indicated in the sentence. Therefore, Prednisolone could help manage EGPA symptoms, at least partly, by decreasing alveolar NO levels, although this is not explicitly stated in the sentence provided." -11213963,Prednisolone related to leprosy,240,"Prednisolone treatment of sensory impairment of the ulnar and posterior tibial nerves detectable with the monofilament test, but not with the ballpen test, did not improve the long-term outcome in terms of recovery of touch sensibility, not did it reduce the risk of leprosy reactions or nerve function impairment beyond the initial 4-month treatment phase.",False,"Is the triple 'Prednisolone related to leprosy' supported by the sentence: 'Prednisolone treatment of sensory impairment of the ulnar and posterior tibial nerves detectable with the monofilament test, but not with the ballpen test, did not improve the long-term outcome in terms of recovery of touch sensibility, not did it reduce the risk of leprosy reactions or nerve function impairment beyond the initial 4-month treatment phase.'?","No, this sentence does not provide support for a direct link between Prednisolone and leprosy. In fact, it suggests that Prednisolone treatment does not reduce the risk of leprosy reactions or nerve function impairment beyond the initial 4-month treatment phase in patients with sensory impairment detected through specific tests (the monofilament test but not the ballpen test). Therefore, it does not imply that Prednisolone is directly associated with preventing or treating leprosy itself, but rather it may have some effect on certain symptoms associated with sensory impairment in patients already affected by the disease during a specific time frame." -11179224,Prednisolone related to alcoholic hepatitis,241,CONCLUSIONS: Predocol is an oral preparation of a poorly absorbed salt of prednisolone that is effective in reducing inflammation over short treatment periods in patients with active ulcerative colitis.,False,Is the triple 'Prednisolone related to alcoholic hepatitis' supported by the sentence: 'CONCLUSIONS: Predocol is an oral preparation of a poorly absorbed salt of prednisolone that is effective in reducing inflammation over short treatment periods in patients with active ulcerative colitis.'?,"No, this sentence does not provide any indirect support for a relationship between Prednisolone and alcoholic hepatitis. The sentence discusses the effectiveness of Predicol, an oral preparation of Prednisolone, in reducing inflammation in patients with active ulcerative colitis over short treatment periods. It does not mention or imply any connection to alcoholic hepatitis." -11142916,Prednisolone related to lupus nephritis,242,"Six weeks prior to his symptoms, prednisolone (PSL) and SASP had been started because of UC aggravation.",True,"Is the triple 'Prednisolone related to lupus nephritis' supported by the sentence: 'Six weeks prior to his symptoms, prednisolone (PSL) and SASP had been started because of UC aggravation.'?","Yes, this sentence does provide indirect support for the connection between prednisolone (PSL) and lupus nephritis in this context. This is because prednisolone is often used as an immunosuppressive drug in treating various autoimmune diseases, such as ulcerative colitis (UC) mentioned in this sentence, as well as lupus nephritis, which is a severe complication in systemic lupus erythematosus (SLE) patients characterized by kidney inflammation. However, it does not confirm direct causation, since other factors could have contributed to the symptoms experienced by this individual, such as disease severity, co-morbidities, or treatment side-effects." -11037266,Prednisolone related to granulomatosis with polyangiitis,243,"When comparing organ specific, age-adjusted expected versus observed incidences after natural death of animals an increased tumor risk was found in organ systems of all treatment modalities but prednisolone.",False,"Is the triple 'Prednisolone related to granulomatosis with polyangiitis' supported by the sentence: 'When comparing organ specific, age-adjusted expected versus observed incidences after natural death of animals an increased tumor risk was found in organ systems of all treatment modalities but prednisolone.'?","No, this statement does not indirectly support a relationship between Prednisolone and granulomatosis with polyangiitis. The sentence is discussing an increased tumor risk in organ systems associated with all treatment modalities except Prednisolone, while granulomatosis with polyangiitis is an autoimmune disease, not a type of cancer." -11013570,Prednisolone related to leukemia,244,"R-CHOP chemotherapy composed of rituximab, cyclophosphamide, adriamycin, vincristine, and prednisolone which might increase the risk of Pneumocystis pneumonia in patients with non-Hodgkin lymphoma.",True,"Is the triple 'Prednisolone related to leukemia' supported by the sentence: 'R-CHOP chemotherapy composed of rituximab, cyclophosphamide, adriamycin, vincristine, and prednisolone which might increase the risk of Pneumocystis pneumonia in patients with non-Hodgkin lymphoma.'?","Yes, this sentence does provide indirect evidence suggesting a relationship between Prednisolone and leukemia, specifically non-Hodgkin lymphoma, in this context. Prednisolone is one of the components in R-CHOP chemotherapy, which is used to treat non-Hodgkin lymphoma. However, it does not directly state that Prednisolone causes leukemia, but rather increases the risk for Pneumocystis pneumonia in these patients undergoing chemotherapy treatment, which is a separate medical issue from leukemia itself." -10949449,Prednisolone related to polymyalgia rheumatica,245,"Cortisol deficiency is common in late stage HIV disease, but symptoms of fatigue and postural hypotension, as well as biochemical findings, are poor predictors of cortisol deficiency.",False,"Is the triple 'Prednisolone related to polymyalgia rheumatica' supported by the sentence: 'Cortisol deficiency is common in late stage HIV disease, but symptoms of fatigue and postural hypotension, as well as biochemical findings, are poor predictors of cortisol deficiency.'?","No, this sentence does not provide indirect support for the relationship between Prednisolone and polymyalgia rheumatica. The sentence discusses cortisol deficiency in late-stage HIV disease, but it does not mention Prednisolone or polymyalgia rheumatica. Prednisolone is a synthetic glucocorticoid often used in the treatment of inflammatory conditions such as polymyalgia rheumatica, but this sentence does not provide any information about this relationship." -10748640,Prednisolone related to infertility disorder,246,[Plasma cortisol and 17-ketosteroids in urine in relation to cardiac arrest].,False,Is the triple 'Prednisolone related to infertility disorder' supported by the sentence: '[Plasma cortisol and 17-ketosteroids in urine in relation to cardiac arrest].'?,"No, this sentence does not provide any support for the relationship between Prednisolone and infertility disorders. Prednisolone is a synthetic glucocorticoid used in various medical conditions for its anti-inflammatory and immunosuppressive effects. The sentence in question discusses plasma cortisol and 17-ketosteroids in urine in relation to cardiac arrest, which does not involve any discussion about Prednisolone or its potential relationship with infertility disorders." -10744705,"Prednisolone related to dermatitis, atopic",247,"Independence of theta and TL surface antigens and killing by thymidine, cortisol, phytohemagglutinin, and cyclic AMP in a murine lymphoma.",False,"Is the triple 'Prednisolone related to dermatitis, atopic' supported by the sentence: 'Independence of theta and TL surface antigens and killing by thymidine, cortisol, phytohemagglutinin, and cyclic AMP in a murine lymphoma.'?","No, this statement does not provide any direct or indirect evidence linking Prednisolone to atopic dermatitis. Prednisolone is a synthetic glucocorticoid often used in treating inflammatory diseases like atopic dermatitis; however, this statement discusses the independence of certain antigens and killing factors in murine lymphoma cells, which does not relate to Prednisolone's effect on atopic dermatitis in humans." -10736101,Prednisolone related to Graves disease,248,"Furthermore, this treatment process demonstrated the superior anti-inflammatory effect of prednisolone over that of hydrocortisone and supported the assumption of inflammation related to CD.",False,"Is the triple 'Prednisolone related to Graves disease' supported by the sentence: 'Furthermore, this treatment process demonstrated the superior anti-inflammatory effect of prednisolone over that of hydrocortisone and supported the assumption of inflammation related to CD.'?","No, this sentence does not provide direct or indirect evidence supporting a relationship between Prednisolone and Graves Disease (CD). The sentence only discusses Prednisolone's superior anti-inflammatory effect compared to Hydrocortisone, and its potential role in reducing inflammation in general, which is not specific to CD (Graves Disease)." -10735679,Prednisolone related to kidney disorder,249,"Ordinary least squared (OLS) regression was used to evaluate whether race moderated the associations between alcohol abuse and four biomarkers-urinary cortisol and serum dehydroepiandrosterone sulfate (DHEA-S), epinephrine and norepinephrine-and two composite summary scores, each consisting of two components that characterize the hypothalamic pituitary adrenal (HPA)-axis and sympathetic nervous systems (SNS), respectively.",False,"Is the triple 'Prednisolone related to kidney disorder' supported by the sentence: 'Ordinary least squared (OLS) regression was used to evaluate whether race moderated the associations between alcohol abuse and four biomarkers-urinary cortisol and serum dehydroepiandrosterone sulfate (DHEA-S), epinephrine and norepinephrine-and two composite summary scores, each consisting of two components that characterize the hypothalamic pituitary adrenal (HPA)-axis and sympathetic nervous systems (SNS), respectively.'?","No, this sentence does not provide any direct or indirect evidence supporting a relationship between Prednisolone and kidney disorders. This sentence discusses an OLS regression study evaluating whether race moderates the associations between alcohol abuse and four specific biomarkers, as well as two composite summary scores associated with HPA-axis and SNS systems, respectively. Prednisolone is not mentioned in this context, so there is no connection to be made based on this information alone." -10715297,Prednisolone related to keratitis,250,"CONCLUSION: In patients with septic shock, low-dose hydrocortisone was associated with a lower risk of developing AF during the acute phase.",False,"Is the triple 'Prednisolone related to keratitis' supported by the sentence: 'CONCLUSION: In patients with septic shock, low-dose hydrocortisone was associated with a lower risk of developing AF during the acute phase.'?","No, the sentence does not provide any indirect support for the relationship between Prednisolone and keratitis. The sentence discusses the association between low-dose hydrocortisone and a lower risk of developing atrial fibrillation (AF) in patients with septic shock. It does not mention Prednisolone or keratitis." -10703266,Prednisolone related to ulcerative colitis,251,"The incidence of psychological symptoms as somatization, obsessive-compulsive symptoms, depression, anxiety, phobia, and nonspecific symptoms is statistically increased in pregnant women with elevated morning cortisol, but in women with elevated afternoon cortisol also occurring aggressiveness and paranoia.",False,"Is the triple 'Prednisolone related to ulcerative colitis' supported by the sentence: 'The incidence of psychological symptoms as somatization, obsessive-compulsive symptoms, depression, anxiety, phobia, and nonspecific symptoms is statistically increased in pregnant women with elevated morning cortisol, but in women with elevated afternoon cortisol also occurring aggressiveness and paranoia.'?","No, this sentence does not provide evidence for an indirect relationship between Prednisolone, which is a synthetic glucocorticoid used in treating inflammatory conditions like ulcerative colitis, and elevated cortisol levels in pregnant women. The sentence discusses the psychological symptoms associated with elevated cortisol levels at different times of day in pregnant women, but it does not mention Prednisolone or its relation to these symptoms or ulcerative colitis." -10687782,Prednisolone related to hepatocellular carcinoma,252,How stress gets under the skin: cortisol and stress reactivity in psoriasis.,False,Is the triple 'Prednisolone related to hepatocellular carcinoma' supported by the sentence: 'How stress gets under the skin: cortisol and stress reactivity in psoriasis.'?,"No, this sentence does not provide direct or indirect evidence supporting a link between Prednisolone, which is a glucocorticoid often used as an anti-inflammatory drug, and hepatocellular carcinoma, which is a type of liver cancer. The sentence discusses cortisol, which is a stress hormone, and its role in psoriasis, which is an autoimmune disease characterized by red, itchy scaly patches on the skin. Prednisolone can affect cortisol levels, but there is no mention of liver cancer in this sentence." -10623724,Prednisolone related to hemolytic anemia,253,Absorption of hydrocortisone from the skin reservoir in atopic dermatitis.,False,Is the triple 'Prednisolone related to hemolytic anemia' supported by the sentence: 'Absorption of hydrocortisone from the skin reservoir in atopic dermatitis.'?,"No, this sentence does not provide any support for a relationship between Prednisolone and hemolytic anemia. Prednisolone is a synthetic glucocorticoid often used in inflammation reduction, while hydrocortisone is a naturally occurring glucocorticoid used for similar purposes. Hemolytic anemia is not mentioned in the sentence, nor is it implied in any way. The sentence only discusses absorption of hydrocortisone from the skin reservoir in atopic dermatitis, which does not relate to Prednisolone or hemolytic anemia." -10576837,Prednisolone related to juvenile idiopathic arthritis,254,OBJECTIVE: To assess dexamethasone (DEX) and hydrocortisone (HC) use in premature infants over time and the association of steroid use with the incidence of bronchopulmonary dysplasia (BPD) at 36 weeks' postmenstrual age.,False,Is the triple 'Prednisolone related to juvenile idiopathic arthritis' supported by the sentence: 'OBJECTIVE: To assess dexamethasone (DEX) and hydrocortisone (HC) use in premature infants over time and the association of steroid use with the incidence of bronchopulmonary dysplasia (BPD) at 36 weeks' postmenstrual age.'?,"No, this sentence does not provide support for the relationship between Prednisolone, juvenile idiopathic arthritis, and premature infants. The sentence discusses dexamethasone (DEX) and hydrocortisone (HC) use in premature infants, not Prednisolone, and their association with bronchopulmonary dysplasia (BPD), not juvenile idiopathic arthritis. Prednisolone is a different type of corticosteroid from DEX and HC, and it is used to treat various conditions, including some types of arthritis, but not necessarily juvenile idiopathic arthritis, which is a specific type of arthritis with multiple potential causes, including genetic factors, infections, and environmental triggers. Therefore, more specific information is needed to establish any potential indirect relationship between Prednisolone, juvenile idiopathic arthritis, and premature infants." -10565620,Prednisolone related to nephrotic syndrome,255,Increased ratio of mRNA expression of the genes CYP17 and CYP11B1 indicates autonomous cortisol production in adrenocortical tumors.,False,Is the triple 'Prednisolone related to nephrotic syndrome' supported by the sentence: 'Increased ratio of mRNA expression of the genes CYP17 and CYP11B1 indicates autonomous cortisol production in adrenocortical tumors.'?,"No, this sentence does not provide any direct or indirect support for the statement that Prednisolone is related to nephrotic syndrome. The sentence discusses autonomous cortisol production in adrenocortical tumors, which is not directly linked to Prednisolone or nephrotic syndrome. Prednisolone is a synthetic glucocorticoid often used in treating inflammatory diseases, while nephrotic syndrome is a kidney disorder characterized by proteinuria, hypoalbuminemia, and edema, which may be treated with corticosteroids, including Prednisolone, but this sentence does not make this connection explicit or implicit." -10531966,Prednisolone related to allergic disease,256,"It is concluded that bile acids are potent endogenous inhibitors of 11 beta-HSD and, therefore, could participate in abnormalities of cortisol metabolism observed in liver cirrhosis and extrahepatic biliary obstruction and, possibly, after ingestion of bile acids.",False,"Is the triple 'Prednisolone related to allergic disease' supported by the sentence: 'It is concluded that bile acids are potent endogenous inhibitors of 11 beta-HSD and, therefore, could participate in abnormalities of cortisol metabolism observed in liver cirrhosis and extrahepatic biliary obstruction and, possibly, after ingestion of bile acids.'?","No, this sentence does not indirectly support Prednisolone being related to allergic diseases. The sentence discusses how bile acids affect cortisol metabolism, specifically in liver cirrhosis, extrahepatic biliary obstruction, and possibly after ingestion of bile acids. Prednisolone is a glucocorticoid, which can be used in treating various conditions, including allergies, but there is no connection made between bile acids, cortisol metabolism, and Prednisolone in this sentence." -10527508,Prednisolone related to acute myeloid leukemia,257,"The plasma cortisol concentration was significantly higher in both DD groups before treatment than in the control group, and it decreased significantly after hoof trimming in the trimmed group.",False,"Is the triple 'Prednisolone related to acute myeloid leukemia' supported by the sentence: 'The plasma cortisol concentration was significantly higher in both DD groups before treatment than in the control group, and it decreased significantly after hoof trimming in the trimmed group.'?","No, this statement does not provide support for a direct link between Prednisolone and acute myeloid leukemia. Prednisolone is a synthetic glucocorticoid often used in treating various medical conditions due to its anti-inflammatory properties, while acute myeloid leukemia is a type of cancer affecting bone marrow cells. - The sentence in question refers to plasma cortisol concentration, which is a stress hormone naturally produced in the body, in relation to hoof trimming in different groups (trimmed, non-trimmed, and control). It does not mention Prednisolone or any other medication used in treating leukemia, nor does it imply any correlation between cortisol levels and leukemia risk. - To establish an indirect relationship, one would need additional information linking cortisol levels, hoof trimming, and risk factors associated with acute myeloid leukemia, which is not provided in this sentence." -10503828,Prednisolone related to seasonal allergic rhinitis,258,Hydrocortisone in culture protects the blast cells in acute myeloblastic leukemia from the lethal effects of cytosine arabinoside.,False,Is the triple 'Prednisolone related to seasonal allergic rhinitis' supported by the sentence: 'Hydrocortisone in culture protects the blast cells in acute myeloblastic leukemia from the lethal effects of cytosine arabinoside.'?,"No, this statement does not indirectly support the relationship between Prednisolone and seasonal allergic rhinitis. The sentence mentions Hydrocortisone, which is a different glucocorticoid, in relation to acute myeloblastic leukemia, not Prednisolone nor seasonal allergic rhinitis." -10496403,Prednisolone related to Inflammation,259,Continuous subcutaneous hydrocortisone infusion in Addison's disease.,False,Is the triple 'Prednisolone related to Inflammation' supported by the sentence: 'Continuous subcutaneous hydrocortisone infusion in Addison's disease.'?,"No, this sentence does not provide direct or indirect support for the statement that Prednisolone is related to inflammation through continuous subcutaneous hydrocortisone infusion in Addison's disease. This is because Prednisolone is a synthetic glucocorticoid, while hydrocortisone is also a glucocorticoid, but it is naturally occurring in the body. Both Prednisolone and hydrocortisone have anti-inflammatory effects, but they belong to different classes (synthetic vs natural). Addison's disease is characterized by insufficient production of hormones, including cortisol, which can be supplemented through hydrocortisone infusion, but there is no direct link between this process and Prednisolone in terms of inflammation based on this sentence alone." -10118116,Prednisolone related to Prednisone,260,The current findings underline the relevance of cortisol and DHEA assessments and the need for further scrutiny of their interplay to foster our understanding of the biological basis of stress regulation in BPD.,False,Is the triple 'Prednisolone related to Prednisone' supported by the sentence: 'The current findings underline the relevance of cortisol and DHEA assessments and the need for further scrutiny of their interplay to foster our understanding of the biological basis of stress regulation in BPD.'?,"No, this sentence does not provide any direct or indirect support for the relationship between Prednisolone, Prednisone, cortisol, DHEA, stress regulation, or BPD (Borderline Personality Disorder). The sentence discusses cortisol and DHEA assessments in relation to stress regulation in BPD, but it does not mention, suggest, nor imply any connection between these hormones/drugs in question." -9924521,Prednisolone related to colitis,261,"This hypoxia-specific increase in surface beta-adrenoreceptors was significantly enhanced in the cortisol-treated erythrocytes, showing that cortisol had a significant impact on erythrocyte beta-adrenoreceptor dynamics in addition to the direct influence of hypoxia.",False,"Is the triple 'Prednisolone related to colitis' supported by the sentence: 'This hypoxia-specific increase in surface beta-adrenoreceptors was significantly enhanced in the cortisol-treated erythrocytes, showing that cortisol had a significant impact on erythrocyte beta-adrenoreceptor dynamics in addition to the direct influence of hypoxia.'?","No, this sentence does not provide direct evidence for Prednisolone being related to colitis, as it discusses cortisol, hypoxia, erythrocyte beta-adrenoreceptors, and their dynamics, but does not mention Prednisolone nor colitis directly. Prednisolone is a synthetic glucocorticoid, similar in function to cortisol, but without an explicit reference, no indirect relation can be inferred either." -9437304,Prednisolone related to systemic lupus erythematosus,262,"Congenital adrenal hyperplasia (CAH) due to deficiency of 21-hydroxylase is a disorder of the adrenal cortex characterised by cortisol deficiency, with or without aldosterone deficiency, and androgen excess.",False,"Is the triple 'Prednisolone related to systemic lupus erythematosus' supported by the sentence: 'Congenital adrenal hyperplasia (CAH) due to deficiency of 21-hydroxylase is a disorder of the adrenal cortex characterised by cortisol deficiency, with or without aldosterone deficiency, and androgen excess.'?","No, this sentence does not provide indirect evidence for a relationship between Prednisolone and systemic lupus erythematosus (SLE). The sentence discusses congenital adrenal hyperplasia (CAH), which is caused by a deficiency in 21-hydroxylase, leading to cortisol deficiency, aldosterone deficiency, and androgen excess. Prednisolone is a synthetic glucocorticoid often used in treating SLE, but it is not mentioned in this sentence, nor is there any connection made between CAH, Prednisolone, and SLE in this context." -9282196,Prednisolone related to IgA glomerulonephritis,263,"Changes of smoking behavior and serum adrenocorticotropic hormone, cortisol, prolactin, and endogenous opioids levels in nicotine dependence after naltrexone treatment.",False,"Is the triple 'Prednisolone related to IgA glomerulonephritis' supported by the sentence: 'Changes of smoking behavior and serum adrenocorticotropic hormone, cortisol, prolactin, and endogenous opioids levels in nicotine dependence after naltrexone treatment.'?","No, this sentence does not provide any indirect support for the relationship between Prednisolone and IgA glomerulonephritis. The sentence discusses changes in smoking behavior, serum adrenocorticotropic hormone, cortisol, prolactin, and endogenous opioids levels in nicotine dependence after naltrexone treatment, but it does not mention Prednisolone, which is a synthetic corticosteroid, nor does it mention IgA glomerulonephritis, which is a kidney disease caused by inflammation in the filtering units (glomeruli) in the kidney." -9222009,Prednisolone related to hypereosinophilic syndrome,264,We hypothesize that hydrocortisone infusion in severe community-acquired pneumonia attenuates systemic inflammation and leads to earlier resolution of pneumonia and a reduction in sepsis-related complications.,True,Is the triple 'Prednisolone related to hypereosinophilic syndrome' supported by the sentence: 'We hypothesize that hydrocortisone infusion in severe community-acquired pneumonia attenuates systemic inflammation and leads to earlier resolution of pneumonia and a reduction in sepsis-related complications.'?,"Yes, there is indirect support for a connection between Prednisolone and hypereosinophilic syndrome in this sentence. Prednisolone is a type of corticosteroid, similar to hydrocortisone, which is mentioned in the sentence. Corticosteroids like these are often used in managing hypereosinophilic syndrome due to their anti-inflammatory effects, which could help reduce eosinophil levels in the body. Therefore, it is plausible that Prednisolone could also have similar effects in attenuating systemic inflammation, as suggested in the sentence regarding hydrocortisone infusion in severe community-acquired pneumonia. However, it is essential to consider further evidence from clinical studies and expert opinions for making more definitive conclusions about this connection." -9216084,Prednisolone related to non-Hodgkin lymphoma,265,A prospective study was performed to investigate the combination of the aromatase inhibitor aminoglutethimide and hydrocortisone in androgen-independent prostate cancer with changes in prostate-specific antigen (PSA) level as main determinant for response.,False,Is the triple 'Prednisolone related to non-Hodgkin lymphoma' supported by the sentence: 'A prospective study was performed to investigate the combination of the aromatase inhibitor aminoglutethimide and hydrocortisone in androgen-independent prostate cancer with changes in prostate-specific antigen (PSA) level as main determinant for response.'?,"No, this sentence does not provide support for a relationship between Prednisolone and non-Hodgkin lymphoma. The sentence discusses a study on the combination of the aromatase inhibitor aminoglutethimide and hydrocortisone in treating androgen-independent prostate cancer, not Prednisolone, nor non-Hodgkin lymphoma. Prednisolone is a synthetic glucocorticoid used in various conditions, while hydrocortisone is also a glucocorticoid, but it is naturally produced in the human body as part of the body's response to stress, inflammation, and immune system function. Non-Hodgkin lymphoma is a type of cancer originating from lymphocytes, a type of white blood cell, which plays an essential role in immune function." -9208405,Prednisolone related to Duchenne muscular dystrophy,266,"To investigate the time courses of the effects of the exogenous glucocorticoid agonists dexamethasone (DEX) and hydrocortisone (HYD) and a glucocorticoid antagonist (RU-38486), and to characterize the local and systemic responses in experimental AP.",False,"Is the triple 'Prednisolone related to Duchenne muscular dystrophy' supported by the sentence: 'To investigate the time courses of the effects of the exogenous glucocorticoid agonists dexamethasone (DEX) and hydrocortisone (HYD) and a glucocorticoid antagonist (RU-38486), and to characterize the local and systemic responses in experimental AP.'?","No, this sentence does not provide any direct or indirect evidence supporting a link between Prednisolone and Duchenne Muscular Dystrophy (DMD). The sentence discusses an investigation into the effects of certain substances, including dexamethasone (DEX), hydrocortisone (HYD), and a glucocorticoid antagonist (RU-38486), in an experimental setting, but it does not mention Prednisolone or DMD. Prednisolone is indeed a glucocorticoid, like dexamethasone and hydrocortisone, but without additional context, we cannot infer any relationship between these substances in relation to DMD." -8405261,Prednisolone related to asthma,267,[The adrenal cortex and hydrocortisone metabolism in experimental myocardial infarct].,False,Is the triple 'Prednisolone related to asthma' supported by the sentence: '[The adrenal cortex and hydrocortisone metabolism in experimental myocardial infarct].'?,"No, there is no direct or indirect mentioning of Prednisolone, which is a synthetic glucocorticoid, in this sentence regarding adrenal cortex and hydrocortisone metabolism in experimental myocardial infarct. The adrenal cortex is responsible for producing corticosteroids, such as cortisol (or hydrocortisone), but Prednisolone is not mentioned, nor is there any contextual connection to asthma in this sentence." -7844202,Prednisolone related to chronic obstructive pulmonary disease,268,[Intraarticular hydrocortisone (cortril) in arthritis and osteoarthritis].,False,Is the triple 'Prednisolone related to chronic obstructive pulmonary disease' supported by the sentence: '[Intraarticular hydrocortisone (cortril) in arthritis and osteoarthritis].'?,"No, this sentence does not provide any support for a relationship between Prednisolone and chronic obstructive pulmonary disease (COPD). The sentence mentions intraarticular hydrocortisone (cortril) used in arthritis and osteoarthritis, but it does not mention Prednisolone or COPD. Prednisolone is a synthetic glucocorticoid often used in inflammation reduction, while COPD is a progressive lung disease, so they can be indirectly linked through inflammation, but this sentence does not provide any evidence for such a link." -7323744,Prednisolone related to pemphigus,269,[Use of cortisone and hydrocortisone in eye diseases].,False,Is the triple 'Prednisolone related to pemphigus' supported by the sentence: '[Use of cortisone and hydrocortisone in eye diseases].'?,"No, this sentence does not provide support for the relationship between Prednisolone and pemphigus, nor does it indicate an indirect relationship. Prednisolone is a synthetic glucocorticoid often used in treating various medical conditions, including some skin disorders, but it is not explicitly mentioned in this sentence, which discusses cortisone and hydrocortisone in eye diseases." -7262473,Prednisolone related to rheumatoid arthritis,270,[Topical use of hydrocortisone in otitis externa].,False,Is the triple 'Prednisolone related to rheumatoid arthritis' supported by the sentence: '[Topical use of hydrocortisone in otitis externa].'?,"No, this sentence does not provide support for the triple relationship between Prednisolone, otitis externa, and rheumatoid arthritis, even indirectly. The sentence only mentions topical use of hydrocortisone in otitis externa, which does not involve Prednisolone, nor does it make any connection to rheumatoid arthritis." -7206314,Prednisolone related to pulmonary tuberculosis,271,The use of hydrocortisone in ulcerative colitis: preliminary observations.,False,Is the triple 'Prednisolone related to pulmonary tuberculosis' supported by the sentence: 'The use of hydrocortisone in ulcerative colitis: preliminary observations.'?,"No, this sentence does not provide any direct or indirect support for a relationship between Prednisolone and pulmonary tuberculosis. Prednisolone is a glucocorticoid used in various inflammatory diseases, while hydrocortisone is another type of glucocorticoid. The sentence only mentions the use of hydrocortisone in ulcerative colitis, without making any reference to Prednisolone, tuberculosis, or the lungs." -8856354,Prednisolone related to Prednisone,272,It can therefore be concluded that ointments containing either only E. coli BCS or a combination of BCS and hydrocortisone provide significant relief in perianal eczema as well as in early stages of hemorrhoidal disease.,False,Is the triple 'Prednisolone related to Prednisone' supported by the sentence: 'It can therefore be concluded that ointments containing either only E. coli BCS or a combination of BCS and hydrocortisone provide significant relief in perianal eczema as well as in early stages of hemorrhoidal disease.'?,"No, this sentence does not provide any evidence for a relationship between Prednisolone and Prednisone, directly or indirectly, nor does it mention Escherichia coli BCS (BCS) being combined with either substance. The sentence only discusses ointments containing BCS, alone or in combination with hydrocortisone, providing relief in perianal eczema and early stages of hemorrhoidal disease, which is unrelated to Prednisolone or Prednisone." -26879702,Prednisolone has part acute lymphoblastic leukemia,273,The effect on cortisol supports the above conclusion and is consistent with HPA axis perturbation in opioid dependence as reported in other studies and extends these observations to stable methadone-maintained patients.,False,Is the triple 'Prednisolone has part acute lymphoblastic leukemia' supported by the sentence: 'The effect on cortisol supports the above conclusion and is consistent with HPA axis perturbation in opioid dependence as reported in other studies and extends these observations to stable methadone-maintained patients.'?,"No, this sentence does not provide direct or indirect support for the triple statement ""Prednisolone has part acute lymphoblastic leukemia."" The sentence discusses the effect of cortisol on opioid dependence in methadone-maintained patients, which is unrelated to Prednisolone or acute lymphoblastic leukemia." -26670577,Prednisolone has part plasma cell myeloma,274,Several randomized controlled trials have evaluated the efficacy of a replacement therapy with hydrocortisone in severe sepsis.,False,Is the triple 'Prednisolone has part plasma cell myeloma' supported by the sentence: 'Several randomized controlled trials have evaluated the efficacy of a replacement therapy with hydrocortisone in severe sepsis.'?,"No, this statement does not provide direct or indirect support for the triple statement ""Prednisolone has part plasma cell myeloma."" The statement discusses hydrocortisone, which is another type of corticosteroid, in relation to severe sepsis, not Prednisolone nor its potential relationship to plasma cell myeloma." -18935086,Prednisolone coexists with Prednisone,275,[Diurnal variations in blood glucose and plasma cortisol in juvenile diabetes mellitus without ketoacidosis].,False,Is the triple 'Prednisolone coexists with Prednisone' supported by the sentence: '[Diurnal variations in blood glucose and plasma cortisol in juvenile diabetes mellitus without ketoacidosis].'?,"No, this sentence does not provide any direct or indirect support for the triple statement ""Prednisolone coexists with Prednisone"". The sentence ""Diurnal variations in blood glucose and plasma cortisol in juvenile diabetes mellitus without ketoacidosis."" is about diurnal variations in blood glucose and plasma cortisol in juvenile diabetes mellitus without ketoacidosis, it does not mention anything about Prednisolone or Prednisone. -Prednisolone and Prednisone are both corticosteroids, they have similar effects but they are not the same drug, they don't coexist, one is metabolized into another in the body, but they can't be used together as they have similar effects on the body, it could lead to overdose if used together." -9296680,Prednisolone derives from Prednisone,276,"OBJECTIVES: Elderly women with proximal femur fracture show abnormal persistence of increased cortisol concentrations, which could contribute to the high morbidity associated with this injury.",False,"Is the triple 'Prednisolone derives from Prednisone' supported by the sentence: 'OBJECTIVES: Elderly women with proximal femur fracture show abnormal persistence of increased cortisol concentrations, which could contribute to the high morbidity associated with this injury.'?","No, this statement does not provide direct evidence for the claim ""Prednisolone derives from Prednisone"". The sentence you provided discusses increased cortisol concentrations in elderly women with proximal femur fractures, but it does not mention either Prednisolone or Prednisone. - - Prednisolone is a synthetic glucocorticoid, often used in inflammation management, while Prednisone is an inactive prodrug, converted to Prednisolone in the liver after absorption. However, this transformation is not directly related to cortisol concentrations, as mentioned in the sentence provided. Therefore, there is no indirect evidence supporting the claim in this context either." -26415442,Prednisolone derives from Prednisone,277,"From the compendium presented above, the following statements become evident: 1) Inappropriately low secretion of cortisol in relation to inflammation is a typical feature of the inflammatory disease in patients with RA.",False,"Is the triple 'Prednisolone derives from Prednisone' supported by the sentence: 'From the compendium presented above, the following statements become evident: 1) Inappropriately low secretion of cortisol in relation to inflammation is a typical feature of the inflammatory disease in patients with RA.'?","No, this statement does not provide any direct or indirect evidence to support the claim that Prednisolone derives from Prednisone. The statement discusses cortisol secretion in relation to inflammation in patients with rheumatoid arthritis (RA), but it does not mention either Prednisolone or Prednisone. - - To clarify, Prednisolone is a synthetic glucocorticoid, which is a class of steroid hormones, and it is metabolically related to Prednisone, another synthetic glucocorticoid. Both medications have anti-inflammatory effects, but they have slightly different properties, which can affect their clinical use in certain situations. However, this information is not provided in the statement given in the question." -14808035,Prednisolone physically interacts with Prednisone,278,Hydrocortisone infusion in septic shock differentially regulated the cytokine responses.,False,Is the triple 'Prednisolone physically interacts with Prednisone' supported by the sentence: 'Hydrocortisone infusion in septic shock differentially regulated the cytokine responses.'?,"No, this sentence does not provide support for the triple interaction between Prednisolone, Prednisone, and physical interaction. The sentence mentions Hydrocortisone, which is another type of corticosteroid, and its effect on cytokine responses in septic shock, but it does not mention nor imply any interaction between Prednisolone, Prednisone, or any physical interaction between them." -9296682,Prednisolone physically interacts with Prednisone,279,"BACKGROUND: There is substantial evidence of dysregulation of cortisol secretion, hippocampal abnormalities, and memory deficits in schizophrenia and other psychotic disorders.",False,"Is the triple 'Prednisolone physically interacts with Prednisone' supported by the sentence: 'BACKGROUND: There is substantial evidence of dysregulation of cortisol secretion, hippocampal abnormalities, and memory deficits in schizophrenia and other psychotic disorders.'?","No, this statement does not provide support for the interaction between Prednisolone and Prednisone, because it discusses cortisol secretion, hippocampal abnormalities, memory deficits in schizophrenia, and other psychotic disorders, but it does not mention any interaction between Prednisolone and Prednisone, either directly or indirectly." -27055840,Prednisolone causes glaucoma,280,(2) One of the mechanisms of therapeutic effect of cortisol in asthma might be its inhibitory effect on CA uptake.,False,Is the triple 'Prednisolone causes glaucoma' supported by the sentence: '(2) One of the mechanisms of therapeutic effect of cortisol in asthma might be its inhibitory effect on CA uptake.'?,"No, this sentence does not provide indirect support for the claim that Prednisolone, a synthetic corticosteroid, causes glaucoma. The sentence (2) discusses one possible mechanism of therapeutic effect for cortisol, a naturally occurring hormone, in asthma, which is its potential inhibitory effect on catecholamine (CA) uptake. Prednisolone, as a corticosteroid, shares some mechanisms with cortisol but is not identical to it, nor does this statement imply any adverse effects such as causing glaucoma. Glaucoma is primarily associated with increased intraocular pressure, which is not mentioned in this statement, making it an unlikely indirect connection between Prednisolone use and glaucoma risk." -26677891,Prednisolone causes uveitis,281,"OBJECTIVE: To compare cortisol levels, diurnal cycles of cortisol, and reactivity of cortisol to psychological stress in fibromyalgia (FM) and rheumatoid arthritis (RA) patients in their natural environment, and to examine the effect on results of accounting for differences among the groups in psychological stress and other lifestyle and psychosocial variables.",False,"Is the triple 'Prednisolone causes uveitis' supported by the sentence: 'OBJECTIVE: To compare cortisol levels, diurnal cycles of cortisol, and reactivity of cortisol to psychological stress in fibromyalgia (FM) and rheumatoid arthritis (RA) patients in their natural environment, and to examine the effect on results of accounting for differences among the groups in psychological stress and other lifestyle and psychosocial variables.'?","No, this sentence does not provide direct evidence to support the statement “Prednisolone causes uveitis.” The statement in question suggests a causal relationship between Prednisolone, an oral corticosteroid, and uveitis, an inflammatory condition affecting the eye. However, the provided sentence discusses cortisol levels, diurnal cycles, and reactivity to psychological stress in patients with fibromyalgia (FM) and rheumatoid arthritis (RA) in their natural environment, accounting for differences in psychological stress, lifestyle, and psychosocial variables. The sentence does not mention Prednisolone, uveitis, or any direct association between them, so it cannot provide indirect support for this statement either." -25953223,Prednisolone causes kidney disorder,282,"OBJECTIVES: Recent data suggest that higher plasma cortisol may be associated with hypertension and insulin resistance in otherwise healthy men, as it is in Cushing's syndrome.",False,"Is the triple 'Prednisolone causes kidney disorder' supported by the sentence: 'OBJECTIVES: Recent data suggest that higher plasma cortisol may be associated with hypertension and insulin resistance in otherwise healthy men, as it is in Cushing's syndrome.'?","No, this sentence does not indirectly support the claim that Prednisolone, which is a synthetic form of cortisol, causes kidney disorders. The sentence only mentions an association between higher plasma cortisol levels and hypertension and insulin resistance in otherwise healthy men, similar to what is observed in Cushing's syndrome, which is characterized by excessive cortisol levels. It does not mention any direct or indirect relationship to kidney disorders." -21556285,Prednisolone causes allergic disease,283,"These findings demonstrate 2 types of adrenal insufficiency with different clinical pictures: Type 1 is characterized by cortisol deficiency with hypoglycaemia, low corticoid levels and a low cortisol secretion rate; Type 2 shows aldosterone deficiency with prominent salt loss.",False,"Is the triple 'Prednisolone causes allergic disease' supported by the sentence: 'These findings demonstrate 2 types of adrenal insufficiency with different clinical pictures: Type 1 is characterized by cortisol deficiency with hypoglycaemia, low corticoid levels and a low cortisol secretion rate; Type 2 shows aldosterone deficiency with prominent salt loss.'?","No, this sentence does not provide any direct or indirect support for the statement that Prednisolone causes allergic disease. The sentence describes two types of adrenal insufficiency, but it does not mention Prednisolone, allergies, or any causal relationship between them." -21293782,Prednisolone causes adrenocortical insufficiency,284,"November, a period of reproductive quiescence in the southern hemisphere, with new antler growth and rapid weight gain, is associated with higher mean plasma cortisol concentrations and a greater responsiveness to exogenous ACTH.",False,"Is the triple 'Prednisolone causes adrenocortical insufficiency' supported by the sentence: 'November, a period of reproductive quiescence in the southern hemisphere, with new antler growth and rapid weight gain, is associated with higher mean plasma cortisol concentrations and a greater responsiveness to exogenous ACTH.'?","No, this sentence does not provide direct support for the statement that Prednisolone causes adrenocortical insufficiency. The sentence discusses natural variations in cortisol levels and ACTH responsiveness in deer during a specific period (November) in the southern hemisphere, but it does not mention Prednisolone or adrenocortical insufficiency. Prednisolone is a synthetic glucocorticoid often used to suppress inflammation and the immune response, and its administration can lead to adrenal suppression (or adrenocortical insufficiency) as a side effect due to negative feedback on the hypothalamic-pituitary-adrenal (HPA) axis, but this information is not present in the sentence provided." -20789636,Prednisolone causes ulcerative colitis,285,Cortisol metabolism in human obesity: impaired cortisone-->cortisol conversion in subjects with central adiposity.,False,Is the triple 'Prednisolone causes ulcerative colitis' supported by the sentence: 'Cortisol metabolism in human obesity: impaired cortisone-->cortisol conversion in subjects with central adiposity.'?,"No, this sentence does not provide indirect support for the statement that Prednisolone causes ulcerative colitis. Prednisolone is a synthetic glucocorticoid, which is structurally similar to cortisol, a natural glucocorticoid in the human body. The sentence you provided discusses cortisol metabolism in human obesity, specifically the conversion of cortisone to cortisol, but it does not mention Prednisolone or ulcerative colitis. Therefore, it does not provide any relevant information to support or refute the initial statement." -17230021,Prednisolone causes Headache,286,The hypothalamic-pituitary-adrenal (HPA) axis is one of the key physiological systems that counterbalances this systemic inflammation through changes in adrenocorticotrophic hormone (ACTH) and cortisol.,False,Is the triple 'Prednisolone causes Headache' supported by the sentence: 'The hypothalamic-pituitary-adrenal (HPA) axis is one of the key physiological systems that counterbalances this systemic inflammation through changes in adrenocorticotrophic hormone (ACTH) and cortisol.'?,"No, this sentence does not provide direct evidence to support the claim that Prednisolone causes headaches, nor does it provide indirect evidence linking Prednisolone to headaches. Prednisolone is a synthetic glucocorticoid often used to suppress inflammation, while the sentence discusses the hypothalamic-pituitary-adrenal (HPA) axis, which is involved in stress response and regulating inflammation through ACTH and cortisol. There is no explicit connection between Prednisolone, HPA axis, ACTH, cortisol, and headaches in this sentence." -16304261,Prednisolone causes nephrotic syndrome,287,"The 5 dpf hypoxic exposure also elicited transient increases in whole body cortisol and in crf, uts1, and hsd20b2 expression, key regulators of the endocrine stress response.",False,"Is the triple 'Prednisolone causes nephrotic syndrome' supported by the sentence: 'The 5 dpf hypoxic exposure also elicited transient increases in whole body cortisol and in crf, uts1, and hsd20b2 expression, key regulators of the endocrine stress response.'?","No, this sentence does not provide direct evidence to support the claim that Prednisolone causes nephrotic syndrome. The sentence mentions the effects of hypoxic exposure on cortisol levels and gene expression related to stress response in zebrafish, but it does not mention Prednisolone, nephrotic syndrome, or any direct link between these concepts." -15365269,Prednisolone causes infertility disorder,288,"At multiple regression analyses, HOMA-IR on admission in the IR group significantly correlated with thyroid-stimulating hormone, glucagon, and cortisol.",False,"Is the triple 'Prednisolone causes infertility disorder' supported by the sentence: 'At multiple regression analyses, HOMA-IR on admission in the IR group significantly correlated with thyroid-stimulating hormone, glucagon, and cortisol.'?","No, this sentence does not provide any direct support for the claim that Prednisolone causes infertility disorders. The sentence mentions a correlation between HOMA-IR (Homeostatic Model Assessment for Insulin Resistance) on admission in the IR (Insulin Resistance) group with thyroid-stimulating hormone, glucagon, and cortisol, but it does not mention Prednisolone or any other specific drugs, let alone their effects on fertility." -14373522,Prednisolone causes exfoliative dermatitis,289,"The suppression of the anti-inflammatory effects of cortisol as a result of states of excessive stress leads to hypercatabolic diseases such as AIDS, sepsis and toxic shock syndrome and protein calorie malnutrition (NAIDS).",False,"Is the triple 'Prednisolone causes exfoliative dermatitis' supported by the sentence: 'The suppression of the anti-inflammatory effects of cortisol as a result of states of excessive stress leads to hypercatabolic diseases such as AIDS, sepsis and toxic shock syndrome and protein calorie malnutrition (NAIDS).'?","No, this sentence does not provide indirect support for the statement that Prednisolone causes exfoliative dermatitis. The sentence discusses the suppression of anti-inflammatory effects of cortisol in states of excessive stress, which can lead to certain diseases, but it does not mention Prednisolone, its side effects, or exfoliative dermatitis at all." -10735861,Prednisolone causes contact dermatitis,290,"The suppression of the anti-inflammatory effects of cortisol as a result of states of excessive stress leads to hypercatabolic diseases such as AIDS, sepsis and toxic shock syndrome and protein calorie malnutrition (NAIDS).",False,"Is the triple 'Prednisolone causes contact dermatitis' supported by the sentence: 'The suppression of the anti-inflammatory effects of cortisol as a result of states of excessive stress leads to hypercatabolic diseases such as AIDS, sepsis and toxic shock syndrome and protein calorie malnutrition (NAIDS).'?","No, this sentence does not indirectly support the statement that Prednisolone causes contact dermatitis. The sentence discusses the suppression of anti-inflammatory effects of cortisol in states of excessive stress, leading to certain diseases, but it does not mention Prednisolone, which is a synthetic glucocorticoid used to reduce inflammation, not cause it. Prednisolone does not directly lead to contact dermatitis; in fact, it is often used to treat various skin conditions, but it can have side effects, including skin thinning and easy bruising, which might be confused with signs of contact dermatitis." -10545904,Prednisolone causes pulmonary tuberculosis,291,"We report the case of a 41-year-old nonatopic women with a previous history of eczematous reaction due to hydrocortisone who suffered worsening of her perennial rhinitis in association with perinasal dermatitis from the use of budesonide in nasal spray form, and stomatitis and pharyngitis due to budesonide in a bronchial inhaler.",False,"Is the triple 'Prednisolone causes pulmonary tuberculosis' supported by the sentence: 'We report the case of a 41-year-old nonatopic women with a previous history of eczematous reaction due to hydrocortisone who suffered worsening of her perennial rhinitis in association with perinasal dermatitis from the use of budesonide in nasal spray form, and stomatitis and pharyngitis due to budesonide in a bronchial inhaler.'?","No, this sentence does not support the claim that Prednisolone causes pulmonary tuberculosis. The sentence discusses a case report of a patient who experienced side effects from using budesonide, a different type of corticosteroid, in nasal spray and inhaler forms. There is no mention of Prednisolone or pulmonary tuberculosis in this sentence." -10519611,Prednisolone causes colitis,292,"In this perspective paper, we focus on the neuro-endocrine interactions that occur between progesterone, allopregnanolone, and cortisol during pregnancy, and propose that they align with our previously proposed model of FM pathogenesis based on GABAergic ""weakening"" in a thalamocortical neural loop system.",False,"Is the triple 'Prednisolone causes colitis' supported by the sentence: 'In this perspective paper, we focus on the neuro-endocrine interactions that occur between progesterone, allopregnanolone, and cortisol during pregnancy, and propose that they align with our previously proposed model of FM pathogenesis based on GABAergic ""weakening"" in a thalamocortical neural loop system.'?","No, this statement does not provide any direct or indirect support for the claim that Prednisolone causes colitis. The statement discusses neuro-endocrine interactions between progesterone, allopregnanolone, and cortisol during pregnancy, and their potential alignment with a proposed model of fibromyalgia (FM) pathogenesis based on GABAergic weakening in a thalamocortical neural loop system. Prednisolone is not mentioned in this statement, nor is there any connection made to colitis." -9464043,Prednisolone causes cataract,293,The present study reported a case of hydrocortisone-induced blood pressure reduction in a patient with anterior pituitary hypofunction due to allergic reaction.,False,Is the triple 'Prednisolone causes cataract' supported by the sentence: 'The present study reported a case of hydrocortisone-induced blood pressure reduction in a patient with anterior pituitary hypofunction due to allergic reaction.'?,"No, this statement does not provide any evidence to support the claim that Prednisolone, which is a glucocorticoid medication like hydrocortisone, causes cataracts. The study mentioned only reports a case of blood pressure reduction due to hydrocortisone use in a patient with anterior pituitary hypofunction caused by an allergic reaction. It does not mention anything about cataracts or Prednisolone." -8757881,Prednisolone causes systemic lupus erythematosus,294,Fetal adrenocorticotropic hormone and cortisol increased to peak values within 2.8 hours of induced hypoxia but by 7.2 hours had begun to fall to values that were not significantly different from those at 1.4 hours.,False,Is the triple 'Prednisolone causes systemic lupus erythematosus' supported by the sentence: 'Fetal adrenocorticotropic hormone and cortisol increased to peak values within 2.8 hours of induced hypoxia but by 7.2 hours had begun to fall to values that were not significantly different from those at 1.4 hours.'?,"No, this sentence does not support the claim that Prednisolone causes systemic lupus erythematosus, directly or indirectly. The sentence discusses fetal adrenocorticotropic hormone and cortisol levels in response to hypoxia, but it does not mention Prednisolone or any other drug, let alone any connection to systemic lupus erythematosus." -27658451,Prednisolone affects uveitis,295,Congenital adrenal hyperplasia (CAH) is a chronic condition and individuals are exposed to elevated androgen levels in utero as a result of the endogenous cortisol deficiency.,False,Is the triple 'Prednisolone affects uveitis' supported by the sentence: 'Congenital adrenal hyperplasia (CAH) is a chronic condition and individuals are exposed to elevated androgen levels in utero as a result of the endogenous cortisol deficiency.'?,"No, this sentence does not provide indirect support for the statement ""Prednisolone affects uveitis."" The sentence discusses congenital adrenal hyperplasia (CAH), a chronic condition where individuals have elevated androgen levels in utero due to endogenous cortisol deficiency, but it does not mention prednisolone, uveitis, or any connection between them. Prednisolone is a synthetic glucocorticoid used to treat various conditions, including inflammation, but no such context is provided in this sentence." -27410586,Prednisolone affects castration-resistant prostate carcinoma,296,The results of our study confirm that thymol has strong ameliorative effect against hydrocortisone-induced oxidative stress injury in hepatic tissues.,False,Is the triple 'Prednisolone affects castration-resistant prostate carcinoma' supported by the sentence: 'The results of our study confirm that thymol has strong ameliorative effect against hydrocortisone-induced oxidative stress injury in hepatic tissues.'?,"No, this statement does not support the idea that Prednisolone (a type of corticosteroid, similar to hydrocortisone) affects castration-resistant prostate carcinoma, directly or indirectly. The study referenced only discusses the effects of thymol on hydrocortisone-induced oxidative stress injury in hepatic tissues, providing no link to prostate carcinoma or Prednisolone's potential effects on it." -27323391,Prednisolone affects focal segmental glomerulosclerosis,297,The effects of 8-bromo-cyclic AMP and cyclic AMP agonists (cholera toxin plus hydrocortisone and prostaglandin E2 plus 3-isobutyl-1-methylxanthine) on the cytotoxic activity of T cells generated during murine influenza virus infection have been examined.,False,Is the triple 'Prednisolone affects focal segmental glomerulosclerosis' supported by the sentence: 'The effects of 8-bromo-cyclic AMP and cyclic AMP agonists (cholera toxin plus hydrocortisone and prostaglandin E2 plus 3-isobutyl-1-methylxanthine) on the cytotoxic activity of T cells generated during murine influenza virus infection have been examined.'?,"No, this sentence does not provide support for the statement that Prednisolone affects focal segmental glomerulosclerosis (FSGS). The sentence discusses the effects of certain substances on T cells during murine influenza virus infection, but it does not mention Prednisolone, FSGS, or any related mechanisms. Prednisolone is a type of corticosteroid often used to treat FSGS, but this sentence does not provide any information about its effects on FSGS." -27042309,Prednisolone affects pulmonary eosinophilia,298,Open oral provocation with 100 or 250 mg hydrocortisone in patients with hydrocortisone contact hypersensitivity elicited cutaneous reactions at sites of previous allergic dermatitis caused by hydrocortisone in two patients and at sites of earlier allergic patch test reactions caused by hydrocortisone in the other two patients.,False,Is the triple 'Prednisolone affects pulmonary eosinophilia' supported by the sentence: 'Open oral provocation with 100 or 250 mg hydrocortisone in patients with hydrocortisone contact hypersensitivity elicited cutaneous reactions at sites of previous allergic dermatitis caused by hydrocortisone in two patients and at sites of earlier allergic patch test reactions caused by hydrocortisone in the other two patients.'?,"No, this sentence does not provide indirect support for the statement that Prednisolone affects pulmonary eosinophilia. The sentence discusses the effects of hydrocortisone on patients with hydrocortisone contact hypersensitivity, not prednisolone, nor its effects on pulmonary eosinophilia. Prednisolone is a synthetic glucocorticoid, structurally related to cortisol (hydrocortisone), but it is not directly related to this sentence." -25790510,Prednisolone affects allergic disease,299,"Although initial studies in transgenic mice and humans are encouraging, more data are required to conclusively prove the hypothesis that the adipose-tissue-specific overexpression of HSD1 and the resultant increase in tissue-specific cortisol concentrations result in human obesity, insulin resistance, high blood pressure, and metabolic syndrome.",False,"Is the triple 'Prednisolone affects allergic disease' supported by the sentence: 'Although initial studies in transgenic mice and humans are encouraging, more data are required to conclusively prove the hypothesis that the adipose-tissue-specific overexpression of HSD1 and the resultant increase in tissue-specific cortisol concentrations result in human obesity, insulin resistance, high blood pressure, and metabolic syndrome.'?","No, this sentence does not provide indirect support for the statement that Prednisolone affects allergic disease. The sentence discusses research on transgenic mice and humans, focusing on the effects of adipose-tissue-specific overexpression of HSD1 and increased tissue-specific cortisol concentrations on obesity, insulin resistance, high blood pressure, and metabolic syndrome. There is no mention or implication of Prednisolone or its effects on allergic diseases in this context." -25165576,Prednisolone affects glomerulonephritis,300,"CONCLUSION: Although hydrocortisone has anti-inflammatory properties, it seems to provoke inflammation in the round window membrane after topical instillation.",False,"Is the triple 'Prednisolone affects glomerulonephritis' supported by the sentence: 'CONCLUSION: Although hydrocortisone has anti-inflammatory properties, it seems to provoke inflammation in the round window membrane after topical instillation.'?","No, this sentence does not provide support for the idea that Prednisolone affects glomerulonephritis, directly or indirectly. The sentence discusses hydrocortisone, which is a different type of corticosteroid, and its effects on the round window membrane, not glomerulonephritis. Prednisolone and hydrocortisone have different chemical structures, pharmacokinetics, and therapeutic indications, although they both belong to the class of corticosteroids. Therefore, the effects observed for hydrocortisone cannot be directly translated to Prednisolone in this context." -24270725,Prednisolone affects dermatomyositis,301,"Type 2 glucocorticoid receptors (GRs), which are occupied by cortisol in humans in times of stress, are thought to be responsible for the glucocorticoid-induced memory impairment.",False,"Is the triple 'Prednisolone affects dermatomyositis' supported by the sentence: 'Type 2 glucocorticoid receptors (GRs), which are occupied by cortisol in humans in times of stress, are thought to be responsible for the glucocorticoid-induced memory impairment.'?","No, this sentence does not provide support for the statement that Prednisolone affects dermatomyositis, directly or indirectly. The sentence discusses the role of type 2 glucocorticoid receptors (GRs) in glucocorticoid-induced memory impairment, but it does not mention Prednisolone or dermatomyositis. Prednisolone is a type of glucocorticoid, but the sentence does not make any connection between Prednisolone, GRs, and dermatomyositis." -22922261,Prednisolone affects allergic bronchopulmonary aspergillosis,302,"Firstly, the GH-mediated increase in cortisol metabolism (mediated via reduced E to F conversion) may precipitate adrenal insufficiency in hypopituitary patients with partial adrenocorticotropic hormone deficiency commencing GH therapy.",False,"Is the triple 'Prednisolone affects allergic bronchopulmonary aspergillosis' supported by the sentence: 'Firstly, the GH-mediated increase in cortisol metabolism (mediated via reduced E to F conversion) may precipitate adrenal insufficiency in hypopituitary patients with partial adrenocorticotropic hormone deficiency commencing GH therapy.'?","No, this sentence does not provide direct support for the statement that Prednisolone affects allergic bronchopulmonary aspergillosis. The sentence discusses the effect of Growth Hormone (GH) therapy on cortisol metabolism in hypopituitary patients, which is not directly related to Prednisolone or allergic bronchopulmonary aspergillosis. Prednisolone is a corticosteroid often used to treat various inflammatory and immune-related conditions, including some forms of lung disease, but this sentence does not provide evidence for its specific effect on allergic bronchopulmonary aspergillosis." -19824794,Prednisolone affects colitis,303,"From this study it is inferred that the group III steroid betamethasone dipropionate alone heals experimentally induced external otitis more rapidly than hydrocortisone with oxytetracycline, with or without polymyxin B.",False,"Is the triple 'Prednisolone affects colitis' supported by the sentence: 'From this study it is inferred that the group III steroid betamethasone dipropionate alone heals experimentally induced external otitis more rapidly than hydrocortisone with oxytetracycline, with or without polymyxin B.'?","No, this sentence does not provide support for the statement that Prednisolone affects colitis, because it discusses the effects of betamethasone dipropionate on experimentally induced external otitis, not Prednisolone on colitis. Prednisolone is a type of glucocorticoid steroid, while betamethasone dipropionate is a type of synthetic glucocorticoid steroid, so they belong to the same class of drugs but are not exactly the same. Additionally, external otitis is an inflammation of the outer ear, while colitis is an inflammation of the colon, so they affect different parts of the body. Therefore, this sentence does not provide any direct or indirect evidence for the effects of Prednisolone on colitis." -19409335,Prednisolone affects sarcoidosis,304,"In conclusion, the reciprocal expression of CYP17 and the transcriptional repressors COUP-TF and DAX-1 indicates that these orphan receptors have a pathophysiologic role in the excessive hormone production in cortisol- and deoxycorticosterone-producing adrenocortical tumors.",False,"Is the triple 'Prednisolone affects sarcoidosis' supported by the sentence: 'In conclusion, the reciprocal expression of CYP17 and the transcriptional repressors COUP-TF and DAX-1 indicates that these orphan receptors have a pathophysiologic role in the excessive hormone production in cortisol- and deoxycorticosterone-producing adrenocortical tumors.'?","No, this sentence does not provide direct or indirect support for the statement ""Prednisolone affects sarcoidosis."" The sentence discusses the role of certain orphan receptors in excessive hormone production in adrenocortical tumors, but it does not mention Prednisolone, sarcoidosis, or their relationship. Prednisolone is a synthetic glucocorticoid, often used as an anti-inflammatory drug, while sarcoidosis is a disease characterized by noncaseating granulomas, which can affect multiple organs, including lungs, skin, eyes, and lymph nodes, among others. Although Prednisolone can be used to treat sarcoidosis, this particular sentence does not provide any evidence for such an association, making it indirectly unrelated to the original statement." -18736907,Prednisolone affects asthma,305,"The administration of hydrocortisone before tumor inoculation resulted in increased tumor take, reduced mean survival time of mice, and concentration of tumor metastasis in a specific organ (i.e., lung metastasis for Ehrlich hypotetraploid clone 1 tumor, and liver metastasis for Ehrlich hypotetraploid stock and Ehrlich hyperdiploid stock tumors).",False,"Is the triple 'Prednisolone affects asthma' supported by the sentence: 'The administration of hydrocortisone before tumor inoculation resulted in increased tumor take, reduced mean survival time of mice, and concentration of tumor metastasis in a specific organ (i.e., lung metastasis for Ehrlich hypotetraploid clone 1 tumor, and liver metastasis for Ehrlich hypotetraploid stock and Ehrlich hyperdiploid stock tumors).'?","No, this sentence does not provide support for the claim that Prednisolone affects asthma, even indirectly. The sentence only mentions the administration of hydrocortisone, which is a different glucocorticoid, in a mouse tumor model. Prednisolone is not mentioned in this sentence, nor is there any connection made to asthma. Therefore, this sentence does not provide any relevant information to support the claim." -17668631,Prednisolone affects Prednisone,306,"Cortisol counteracts the insulin activation of glycogen synthase in muscle, the insulin inhibition of hepatic glucose production and the insulin inhibition of lipolysis in adipose tissue, leading to the well-established systemic insulin resistance caused by excess cortisol.",False,"Is the triple 'Prednisolone affects Prednisone' supported by the sentence: 'Cortisol counteracts the insulin activation of glycogen synthase in muscle, the insulin inhibition of hepatic glucose production and the insulin inhibition of lipolysis in adipose tissue, leading to the well-established systemic insulin resistance caused by excess cortisol.'?","No, this sentence does not provide direct support for the statement ""Prednisolone affects Prednisone."" The sentence discusses the effects of cortisol on various metabolic processes, but it does not mention either Prednisolone or Prednisone, nor does it imply any relationship between these drugs." -15888410,Prednisolone affects rheumatoid arthritis,307,"The amount of N-acetyl D-glucosamine in the zymogen granule membrane was not altered by caerulein acute pancreatitis induced under continuous hydrocortisone treatment, but it was decreased by the administration of L-364,718 over 7 days after pancreatitis induction.",False,"Is the triple 'Prednisolone affects rheumatoid arthritis' supported by the sentence: 'The amount of N-acetyl D-glucosamine in the zymogen granule membrane was not altered by caerulein acute pancreatitis induced under continuous hydrocortisone treatment, but it was decreased by the administration of L-364,718 over 7 days after pancreatitis induction.'?","No, this sentence does not provide support for the statement that Prednisolone affects rheumatoid arthritis, either directly or indirectly. The sentence discusses the effects of caerulein acute pancreatitis induced under continuous hydrocortisone treatment and the administration of L-364,718 on N-acetyl D-glucosamine levels in zymogen granule membranes, but it does not mention Prednisolone or its effects on rheumatoid arthritis." -13564625,Prednisolone affects asthma,308,False elevation of plasma cortisol in congenital adrenal hyperplasia.,False,Is the triple 'Prednisolone affects asthma' supported by the sentence: 'False elevation of plasma cortisol in congenital adrenal hyperplasia.'?,"No, this sentence does not support the claim that Prednisolone affects asthma, directly or indirectly. Prednisolone is a synthetic glucocorticoid often used to suppress the immune system, while congenital adrenal hyperplasia is a genetic disorder affecting the adrenal glands. The sentence is discussing an elevation in plasma cortisol levels in congenital adrenal hyperplasia, which is not directly related to Prednisolone use in treating asthma symptoms, even indirectly." -13234063,Prednisolone affects pericarditis,309,Further studies evaluating the mechanism of action and long term effects of hydrocortisone in cardiac arrest need to be conducted.,False,Is the triple 'Prednisolone affects pericarditis' supported by the sentence: 'Further studies evaluating the mechanism of action and long term effects of hydrocortisone in cardiac arrest need to be conducted.'?,"No, this sentence does not provide indirect support for the statement “Prednisolone affects pericarditis.” The sentence discusses hydrocortisone, which is a different medication, in relation to cardiac arrest, not prednisolone in relation to pericarditis. Therefore, there is no connection to be inferred between these two statements." -13029310,Prednisolone affects chronic obstructive pulmonary disease,310,"In acute MI, there were elevated plasma levels of cortisol depending on the MI severity with a small repeated peak of its increase on day 14 and its subsequent decrease, except deaths.",False,"Is the triple 'Prednisolone affects chronic obstructive pulmonary disease' supported by the sentence: 'In acute MI, there were elevated plasma levels of cortisol depending on the MI severity with a small repeated peak of its increase on day 14 and its subsequent decrease, except deaths.'?","No, this sentence does not provide support for the claim that Prednisolone affects Chronic Obstructive Pulmonary Disease (COPD). The sentence is discussing Acute Myocardial Infarction (MI) and plasma levels of cortisol, not COPD or Prednisolone. Prednisolone is a synthetic glucocorticoid often used as an anti-inflammatory drug, but it is not directly mentioned in this sentence, nor is its effect on COPD discussed." -12949384,Prednisolone affects hypereosinophilic syndrome,311,"Aldosterone levels, like cortisol, have been shown to be increased in sepsis and hemorrhagic shock.",False,"Is the triple 'Prednisolone affects hypereosinophilic syndrome' supported by the sentence: 'Aldosterone levels, like cortisol, have been shown to be increased in sepsis and hemorrhagic shock.'?","No, this sentence does not provide indirect support for the statement that Prednisolone affects hypereosinophilic syndrome through Aldosterone levels, like cortisol, being increased in sepsis and hemorrhagic shock. The sentence only mentions increased Aldosterone levels in sepsis and hemorrhagic shock, but it does not mention Prednisolone, hypereosinophilic syndrome, or any connection between them." -12057849,Prednisolone affects Crohn disease,312,"In this review, we summarize the effects of circadian melatonin, TSH, and cortisol on OA, focusing on how different levels of these hormones affect OA pathogenesis and recovery with respect to the circadian clock.",False,"Is the triple 'Prednisolone affects Crohn disease' supported by the sentence: 'In this review, we summarize the effects of circadian melatonin, TSH, and cortisol on OA, focusing on how different levels of these hormones affect OA pathogenesis and recovery with respect to the circadian clock.'?","No, this sentence does not provide indirect support for the statement that Prednisolone affects Crohn disease. The sentence discusses the effects of circadian melatonin, TSH, and cortisol on Osteoarthritis (OA), not Prednisolone or Crohn disease." -11166436,Prednisolone affects Headache,313,"There may be a subset of patients unable to elicit an appropriate immunosuppressive response to stress through upregulation of cortisol, with resultant exacerbation of their psoriasis.",False,"Is the triple 'Prednisolone affects Headache' supported by the sentence: 'There may be a subset of patients unable to elicit an appropriate immunosuppressive response to stress through upregulation of cortisol, with resultant exacerbation of their psoriasis.'?","No, this sentence does not provide support for the idea that Prednisolone, which is an anti-inflammatory drug often used to treat allergies, autoimmune diseases, and skin conditions, directly or indirectly affects headaches. The sentence in question discusses a subset of patients with psoriasis who may not be able to upregulate cortisol appropriately in response to stress, leading to exacerbation of their psoriasis symptoms. While Prednisolone could potentially be used to manage psoriasis, it doesn't necessarily mean it has an impact on headaches." -11074135,Prednisolone affects lymphoma,314,"In addition to local effect, topical hydrocortisone therapy of childhood dermatitis is accompanied by a systemic effect that may be pronounced in the acute phase of disease.",False,"Is the triple 'Prednisolone affects lymphoma' supported by the sentence: 'In addition to local effect, topical hydrocortisone therapy of childhood dermatitis is accompanied by a systemic effect that may be pronounced in the acute phase of disease.'?","No, this sentence does not provide direct support for the idea that Prednisolone affects lymphoma, even indirectly. The sentence discusses the systemic effect of topical hydrocortisone therapy in childhood dermatitis, but it does not mention Prednisolone or lymphoma. Prednisolone is a synthetic glucocorticoid, while hydrocortisone is a natural glucocorticoid, so they have different chemical structures and may have different effects on the body, even though they both belong to the class of glucocorticoids. Therefore, it is not appropriate to make assumptions about the effect of Prednisolone on lymphoma based on this sentence alone." -10651502,Prednisolone affects kidney disorder,315,"They answered the Fibromyalgia Impact Questionnaire (FIQ), Perceived Stress Questionnaire (PSQ) and McGill Pain Questionnaire (MPQ-Br), and collected saliva to evaluate CC before and after the end of each month.",False,"Is the triple 'Prednisolone affects kidney disorder' supported by the sentence: 'They answered the Fibromyalgia Impact Questionnaire (FIQ), Perceived Stress Questionnaire (PSQ) and McGill Pain Questionnaire (MPQ-Br), and collected saliva to evaluate CC before and after the end of each month.'?","No, this sentence does not provide any evidence to support the claim that Prednisolone, a medication used to treat various conditions such as inflammation, allergies, and autoimmune disorders, has an effect on kidney disorders, directly or indirectly. The sentence mentions a study where participants answered questionnaires related to fibromyalgia, stress, and pain, and provided saliva samples for cortisol evaluation before and after each month, but it does not mention Prednisolone, kidneys, or any related disorders." -10649036,Prednisolone affects chorioretinitis,316,"BACKGROUND: The hypothalamic-pituitary-adrenal stress axis plays a crucial role in community-acquired pneumonia (CAP), with high cortisol being associated with disease severity and corticosteroid treatment resulting in earlier time to recovery.",False,"Is the triple 'Prednisolone affects chorioretinitis' supported by the sentence: 'BACKGROUND: The hypothalamic-pituitary-adrenal stress axis plays a crucial role in community-acquired pneumonia (CAP), with high cortisol being associated with disease severity and corticosteroid treatment resulting in earlier time to recovery.'?","No, this sentence does not provide direct support for the statement that Prednisolone affects chorioretinitis, as it discusses the role of corticosteroids in community-acquired pneumonia (CAP), not specifically in chorioretinitis. The hypothalamic-pituitary-adrenal stress axis, cortisol, and corticosteroid treatment are mentioned, but these are broad concepts that apply to many different medical conditions, not specifically to Prednisolone affecting chorioretinitis." -10555139,Prednisolone affects peptic ulcer disease,317,"The incidence of AF was compared among patients who received hydrocortisone, and the effect of low-dose hydrocortisone on AF was estimated using the inverse probability treatment weighting method based on propensity scores.",False,"Is the triple 'Prednisolone affects peptic ulcer disease' supported by the sentence: 'The incidence of AF was compared among patients who received hydrocortisone, and the effect of low-dose hydrocortisone on AF was estimated using the inverse probability treatment weighting method based on propensity scores.'?","No, this sentence does not provide support for the statement ""Prednisolone affects peptic ulcer disease"". Prednisolone is not mentioned in this sentence, nor is any effect on peptic ulcers described. The sentence discusses the incidence of atrial fibrillation (AF) in patients who received hydrocortisone, not prednisolone, and uses statistical methods to estimate the effect of low-dose hydrocortisone on AF." -10183156,Prednisolone affects ulcerative colitis,318,"INTRODUCTION: Intrathecal administration of methotrexate, cytarabine, and hydrocortisone is commonly used to treat and prevent central nervous system involvement in leukemias and lymphomas.",False,"Is the triple 'Prednisolone affects ulcerative colitis' supported by the sentence: 'INTRODUCTION: Intrathecal administration of methotrexate, cytarabine, and hydrocortisone is commonly used to treat and prevent central nervous system involvement in leukemias and lymphomas.'?","No, this sentence does not provide support for the statement that Prednisolone affects ulcerative colitis, directly or indirectly. The sentence mentions intrathecal administration of methotrexate, cytarabine, and hydrocortisone in the context of treating leukemias and lymphomas, but it does not mention Prednisolone nor ulcerative colitis. Prednisolone is a type of corticosteroid often used to treat inflammatory conditions, including some cases of ulcerative colitis, but this information is not provided in the sentence you presented. Therefore, we cannot establish a connection between Prednisolone and ulcerative colitis based on this sentence alone." -9735520,Prednisolone affects Inflammation,319,"INTRODUCTION: Intrathecal administration of methotrexate, cytarabine, and hydrocortisone is commonly used to treat and prevent central nervous system involvement in leukemias and lymphomas.",True,"Is the triple 'Prednisolone affects Inflammation' supported by the sentence: 'INTRODUCTION: Intrathecal administration of methotrexate, cytarabine, and hydrocortisone is commonly used to treat and prevent central nervous system involvement in leukemias and lymphomas.'?","Yes, the sentence does indirectly support the idea that Prednisolone, which is a type of hydrocortisone, can affect inflammation. Hydrocortisone is a steroid hormone used in medical treatment for its anti-inflammatory effects. The sentence mentions its use in treating leukemias and lymphomas, which implies its role in reducing inflammation in these conditions. Prednisolone is also a corticosteroid often used for its anti-inflammatory properties, so it fits into this narrative as well. However, it is important to note that this is an indirect inference, as the original sentence does not explicitly mention Prednisolone or its effects on inflammation." -9361682,Prednisolone affects osteoarthritis,320,"CONCLUSIONS: Early PN did not affect plasma concentrations of ACTH and (free) cortisol, but increased the incidence of septic shock, which statistically explained why more patients on early PN received corticosteroids.",False,"Is the triple 'Prednisolone affects osteoarthritis' supported by the sentence: 'CONCLUSIONS: Early PN did not affect plasma concentrations of ACTH and (free) cortisol, but increased the incidence of septic shock, which statistically explained why more patients on early PN received corticosteroids.'?","No, this sentence does not provide support for the statement that Prednisolone affects osteoarthritis, directly or indirectly. The sentence discusses the effects of early parenteral nutrition (PN) on plasma concentrations of ACTH, cortisol, and the incidence of septic shock, but it does not mention Prednisolone or its effects on osteoarthritis." -8533593,Prednisolone affects neoplasm,321,"Sixteen reacted to tixocortol pivalate and also to other corticosteroids, particularly to hydrocortisone, which could explain exacerbations of eczema in these cases.",False,"Is the triple 'Prednisolone affects neoplasm' supported by the sentence: 'Sixteen reacted to tixocortol pivalate and also to other corticosteroids, particularly to hydrocortisone, which could explain exacerbations of eczema in these cases.'?","No, this sentence does not provide indirect support for the statement that Prednisolone affects neoplasm. The sentence discusses cases where patients reacted to tixocortol pivalate and other corticosteroids, including hydrocortisone, which could explain exacerbations of eczema in these cases. It does not mention Prednisolone nor any relation to neoplasms, which are tumors, abnormal growths, or malignancies." -7800426,Prednisolone affects acute lymphoblastic leukemia,322,"Finally, transient pre-treatment of healthy humans with cortisol induces a bi-phasic response during a later, delayed systemic inflammatory response: an intermediate cortisol concentration augments inflammation while a high cortisol concentration is neither pro- nor anti-inflammatory.",True,"Is the triple 'Prednisolone affects acute lymphoblastic leukemia' supported by the sentence: 'Finally, transient pre-treatment of healthy humans with cortisol induces a bi-phasic response during a later, delayed systemic inflammatory response: an intermediate cortisol concentration augments inflammation while a high cortisol concentration is neither pro- nor anti-inflammatory.'?","Yes, this sentence does provide some indirect evidence for the idea that Prednisolone, which is a synthetic glucocorticoid similar to cortisol, could affect acute lymphoblastic leukemia (ALL). The sentence suggests that cortisol, which is known to have similar effects as Prednisolone, can modulate inflammation in humans. ALL is often associated with an overactive immune response, so it is plausible that modulating this response could have an impact on ALL. However, this is a very indirect link, and more specific research would be needed to directly support this claim." -7395227,Prednisolone affects systemic lupus erythematosus,323,"Adrenaline induces the early posthypoglycaemic insulin resistance, whereas cortisol and growth hormone are important for the insulin resistance that is observed later following hypoglycaemia.",False,"Is the triple 'Prednisolone affects systemic lupus erythematosus' supported by the sentence: 'Adrenaline induces the early posthypoglycaemic insulin resistance, whereas cortisol and growth hormone are important for the insulin resistance that is observed later following hypoglycaemia.'?","No, this sentence does not provide support for the statement that Prednisolone, which is a glucocorticoid like cortisol, affects systemic lupus erythematosus (SLE) at least indirectly. The sentence discusses the roles of adrenaline, cortisol, and growth hormone in insulin resistance following hypoglycaemia, but it does not mention Prednisolone or SLE. Therefore, it does not provide any indirect evidence for the initial statement." -21722189,Prednisolone affects Prednisone,324,"RESULTS: Within 24 hours following TBI, the concentrations of total cortisol, ACTH and gastrin increased proportionally to the severity of injury, especially significant in the experimental group (P less than 0.05).",False,"Is the triple 'Prednisolone affects Prednisone' supported by the sentence: 'RESULTS: Within 24 hours following TBI, the concentrations of total cortisol, ACTH and gastrin increased proportionally to the severity of injury, especially significant in the experimental group (P less than 0.05).'?","No, this sentence does not provide indirect support for the statement ""Prednisolone affects Prednisone."" The sentence mentions results from an experiment involving total cortisol, ACTH, and gastrin concentrations in response to Traumatic Brain Injury (TBI), but there is no mention of Prednisolone or Prednisone in this context." -9655099,Prednisolone has input Prednisone,325,NEW OR UNIQUE INFORMATION PROVIDED: This case is the first published report of hydrocortisone-responsive hypotension and transient CIRCI associated with naturally occurring septic shock in a dog.,False,Is the triple 'Prednisolone has input Prednisone' supported by the sentence: 'NEW OR UNIQUE INFORMATION PROVIDED: This case is the first published report of hydrocortisone-responsive hypotension and transient CIRCI associated with naturally occurring septic shock in a dog.'?,"No, this statement does not indirectly support the triple ""Prednisolone has input Prednisone"". The sentence provided discusses a case report in a dog of hydrocortisone-responsive hypotension and transient Critical Illness-Related Corticosteroid Insufficiency (CIRCI) associated with naturally occurring septic shock, but it does not mention Prednisolone or its relationship to Prednisone." -27206106,Prednisolone disrupts uveitis,326,Several types of the congenital adrenal hyperplasias are associated with decreased cortisol production and excessive adrenal sex steroid secretion.,False,Is the triple 'Prednisolone disrupts uveitis' supported by the sentence: 'Several types of the congenital adrenal hyperplasias are associated with decreased cortisol production and excessive adrenal sex steroid secretion.'?,"No, this statement does not indirectly support the claim that Prednisolone, which is a synthetic glucocorticoid used to suppress inflammation in diseases like uveitis, is disruptive to uveitis. - - The sentence provided discusses congenital adrenal hyperplasias, which are genetic disorders affecting cortisol production and adrenal sex steroid secretion. While Prednisolone is indeed used to manage decreased cortisol production in some contexts, this statement does not provide any information about Prednisolone's impact on uveitis, let alone its potential to disrupt it." -26515767,Prednisolone disrupts neoplasm,327,[Use of cryo-apheresis in the treatment of patients with cortisol-dependent bronchial asthma].,False,Is the triple 'Prednisolone disrupts neoplasm' supported by the sentence: '[Use of cryo-apheresis in the treatment of patients with cortisol-dependent bronchial asthma].'?,"No, this sentence does not provide any direct or indirect support for the statement ""Prednisolone disrupts neoplasm"". The sentence is about the use of cryo-apheresis in treating cortisol-dependent bronchial asthma, not about Prednisolone's effect on neoplasms (abnormal growths). Prednisolone is a synthetic glucocorticoid often used to treat inflammatory diseases such as asthma, but it does not necessarily imply it disrupts neoplasms." -26379811,Prednisolone disrupts contact dermatitis,328,Hypotension after recruitment was reduced by HC (0 vs. 30%).,False,Is the triple 'Prednisolone disrupts contact dermatitis' supported by the sentence: 'Hypotension after recruitment was reduced by HC (0 vs. 30%).'?,"No, this sentence does not provide any support for the statement that Prednisolone disrupts contact dermatitis, directly or indirectly. The sentence is discussing hypotension (low blood pressure) after recruitment, which is not related to Prednisolone or contact dermatitis." -25763558,Prednisolone disrupts pneumonia,329,Fetal plasma cortisol concentrations were increased ( P < 0.05) during all levels of hypoxia.,False,Is the triple 'Prednisolone disrupts pneumonia' supported by the sentence: 'Fetal plasma cortisol concentrations were increased ( P < 0.05) during all levels of hypoxia.'?,"No, this sentence does not provide direct support for the statement that Prednisolone, which is a synthetic glucocorticoid often used to treat inflammation, disrupts pneumonia. The sentence you provided discusses increased fetal plasma cortisol concentrations during hypoxia, but it does not mention Prednisolone or pneumonia. Prednisolone may affect cortisol levels, but this sentence does not provide sufficient evidence to make that connection. Furthermore, even if there was a connection between Prednisolone, cortisol, and hypoxia, it would not necessarily imply a disruption of pneumonia." -25233555,Prednisolone disrupts allergic disease,330,"INTRA-CELL CORTISOL: Attention is also focused on the potential implication of cortisol in the genesis of metabolic syndrome, because cortisol is a potent antagonist of the effect of insulin and its presence in excess enhances visceral obesity and insulin resistance.",True,"Is the triple 'Prednisolone disrupts allergic disease' supported by the sentence: 'INTRA-CELL CORTISOL: Attention is also focused on the potential implication of cortisol in the genesis of metabolic syndrome, because cortisol is a potent antagonist of the effect of insulin and its presence in excess enhances visceral obesity and insulin resistance.'?","Yes, this statement does provide indirect support for the idea that Prednisolone, which is a synthetic glucocorticoid (a type of cortisol) could potentially disrupt allergic disease. This is because cortisol, when present in excess, can enhance visceral obesity and insulin resistance, both of which can contribute to metabolic syndrome. - - Allergic diseases often involve an overactive immune response, and glucocorticoids like Prednisolone are commonly used to suppress this response due to their anti-inflammatory effects. However, long-term use of these drugs can lead to side effects, including metabolic disorders like insulin resistance, obesity, and metabolic syndrome, which could indirectly affect allergic diseases as well. Therefore, while this statement does not directly link cortisol to allergic diseases, it does suggest a potential indirect connection through metabolic syndrome." -14331279,Prednisolone disrupts hypereosinophilic syndrome,331,The effect of hydrocortisone on standardized skin-surface trauma.,False,Is the triple 'Prednisolone disrupts hypereosinophilic syndrome' supported by the sentence: 'The effect of hydrocortisone on standardized skin-surface trauma.'?,"No, it is not directly supported. The sentence mentions hydrocortisone, not prednisolone, which is a different type of corticosteroid medication. Additionally, it discusses the effect on standardized skin-surface trauma, not on hypereosinophilic syndrome specifically." -10594561,Prednisolone disrupts asthma,332,The action of hydrocortisone in synovial inflammation.,False,Is the triple 'Prednisolone disrupts asthma' supported by the sentence: 'The action of hydrocortisone in synovial inflammation.'?,"No, this sentence does not provide indirect support for the statement that Prednisolone, which is similar to hydrocortisone, disrupts asthma. The sentence only mentions the action of hydrocortisone in synovial inflammation, not its effect on asthma. Prednisolone is often used in treating asthma because it is a glucocorticoid like hydrocortisone, but this sentence does not provide evidence for its effectiveness in treating asthma specifically." -8854473,Prednisolone disrupts Inflammation,333,"The effects of stressful life events, coping, and cortisol on HIV infection.",True,"Is the triple 'Prednisolone disrupts Inflammation' supported by the sentence: 'The effects of stressful life events, coping, and cortisol on HIV infection.'?","Yes, this statement is indirectly supported by the sentence provided, as Prednisolone is a synthetic glucocorticoid often used to mimic the effects of cortisol, which is one of the hormones involved in stress response. Glucocorticoids like Prednisolone, as well as stressful life events, can influence cortisol levels, which in turn can affect inflammation, as cortisol is known to have anti-inflammatory effects in the body. However, it is important to note that this connection is inferential, based on known biological functions, rather than being explicitly stated in the sentence itself." -27646185,Prednisolone prevents allergic disease,334,"Immunologic and hemodynamic effects of ""low-dose"" hydrocortisone in septic shock: a double-blind, randomized, placebo-controlled, crossover study.",False,"Is the triple 'Prednisolone prevents allergic disease' supported by the sentence: 'Immunologic and hemodynamic effects of ""low-dose"" hydrocortisone in septic shock: a double-blind, randomized, placebo-controlled, crossover study.'?","No, this sentence does not provide indirect support for the statement ""Prednisolone prevents allergic disease"". The sentence discusses immunologic effects and hemodynamic effects of low-dose hydrocortisone in septic shock, which is not directly related to Prednisolone or its effects on allergies." -26227245,Prednisolone prevents synovitis,335,"To prolong the anti-tumor effect some mice were also given cyclophosphamide, hydrocortisone, or a second injection of virus.",False,"Is the triple 'Prednisolone prevents synovitis' supported by the sentence: 'To prolong the anti-tumor effect some mice were also given cyclophosphamide, hydrocortisone, or a second injection of virus.'?","No, this sentence does not support the triple statement “Prednisolone prevents synovitis.” The sentence mentions cyclophosphamide, hydrocortisone, and virus injections as treatments, but it does not mention Prednisolone, nor does it imply any relationship between these treatments and the prevention of synovitis." -19453072,Prednisolone prevents hypereosinophilic syndrome,336,"In conclusion, HRT in postmenopausal asthmatic women has a favorable influence on the course of asthma, reduces daily use of glucocorticosteroids and frequency of asthma exacerbations and normalizes serum concentrations of estradiol, cortisol and DHEAS, which were decreased before HRT.",False,"Is the triple 'Prednisolone prevents hypereosinophilic syndrome' supported by the sentence: 'In conclusion, HRT in postmenopausal asthmatic women has a favorable influence on the course of asthma, reduces daily use of glucocorticosteroids and frequency of asthma exacerbations and normalizes serum concentrations of estradiol, cortisol and DHEAS, which were decreased before HRT.'?","No, this sentence does not provide indirect support for the statement that Prednisolone prevents hypereosinophilic syndrome in postmenopausal asthmatic women taking HRT (Hormone Replacement Therapy). The sentence discusses the effects of HRT on asthma, serum concentrations of estradiol, cortisol, and DHEAS in postmenopausal asthmatic women, but it does not mention Prednisolone, glucocorticosteroids, or hypereosinophilic syndrome at all." -16706850,Prednisolone prevents neoplasm,337,"However, after adjusting for the effect of obesity by multiple regression, higher plasma cortisol was independently associated with higher diastolic blood pressure in men (r = 0.21, P = 0.04) but not in women, and higher fasting serum triglyceride levels in women (r = 0.28, P < 0. 001) but not in men.",False,"Is the triple 'Prednisolone prevents neoplasm' supported by the sentence: 'However, after adjusting for the effect of obesity by multiple regression, higher plasma cortisol was independently associated with higher diastolic blood pressure in men (r = 0.21, P = 0.04) but not in women, and higher fasting serum triglyceride levels in women (r = 0.28, P < 0. 001) but not in men.'?","No, this sentence does not provide any direct or indirect support for the statement ""Prednisolone prevents neoplasm."" The sentence discusses the association between plasma cortisol levels, diastolic blood pressure, and fasting serum triglyceride levels in men and women, but it does not mention Prednisolone or any other glucocorticoid medication, nor does it discuss any potential effects on neoplasms (tumors). Prednisolone is a synthetic glucocorticoid, but this sentence does not provide any evidence for its potential preventative effects on neoplasms, directly or indirectly." -15809068,Prednisolone prevents colitis,338,"ii) Reduction of cortisone to cortisol in the liver may increase insulin resistance in type 2 diabetes mellitus, and inhibition of the enzyme may lead to a decrease in gluconeogenesis.",False,"Is the triple 'Prednisolone prevents colitis' supported by the sentence: 'ii) Reduction of cortisone to cortisol in the liver may increase insulin resistance in type 2 diabetes mellitus, and inhibition of the enzyme may lead to a decrease in gluconeogenesis.'?","No, this sentence does not provide indirect support for the statement ""Prednisolone prevents colitis"". The sentence discusses the relationship between cortisone, cortisol, insulin resistance, and gluconeogenesis in type 2 diabetes mellitus, but it does not mention Prednisolone, colitis, or their potential relationship." -11858005,Prednisolone prevents asthma,339,"Pretreatment of rats with hydrocortisone or protamin-Zn-insulin within 4 days altered in subsequent acute hypoxia (3 hrs, ""height"" 10 000 m) the isoenzyme spectrum of LDH in lungs, liver tissue and kidney cortex.",False,"Is the triple 'Prednisolone prevents asthma' supported by the sentence: 'Pretreatment of rats with hydrocortisone or protamin-Zn-insulin within 4 days altered in subsequent acute hypoxia (3 hrs, ""height"" 10 000 m) the isoenzyme spectrum of LDH in lungs, liver tissue and kidney cortex.'?","No, this sentence does not indirectly support the statement that Prednisolone prevents asthma. The sentence discusses the effects of two different substances, hydrocortisone and protamin-Zn-insulin, on the isoenzyme spectrum of LDH in lungs, liver tissue, and kidney cortex in rats exposed to acute hypoxia. Prednisolone is not mentioned in this sentence, nor is there any connection made to asthma. Therefore, there is no indirect support for the initial statement." -10983909,Prednisolone prevents leprosy,340,Previously we related persistent cortisol increases to memory impairments in elderly humans studied over five years.,False,Is the triple 'Prednisolone prevents leprosy' supported by the sentence: 'Previously we related persistent cortisol increases to memory impairments in elderly humans studied over five years.'?,"No, this statement does not provide indirect support for the claim that Prednisolone prevents leprosy. Prednisolone is a synthetic glucocorticoid often used to reduce inflammation, while cortisol is a natural glucocorticoid in humans. The sentence you provided discusses a correlation between persistent cortisol increases and memory impairments in elderly humans, but it does not mention Prednisolone, leprosy, or any connection between these subjects." -10240036,Prednisolone prevents Inflammation,341,It was suggested that the progressive shift from type 1 to type 2 cytokine production characteristic of HIV infection could be at least partially provoked by the increase in the production of cortisol and the reduction of DHEA.,True,Is the triple 'Prednisolone prevents Inflammation' supported by the sentence: 'It was suggested that the progressive shift from type 1 to type 2 cytokine production characteristic of HIV infection could be at least partially provoked by the increase in the production of cortisol and the reduction of DHEA.'?,"Yes, this statement could indirectly support the idea that Prednisolone, which is a corticosteroid medication often used to reduce inflammation, could prevent inflammation in the context of HIV infection. The sentence you provided suggests that an increase in cortisol (a hormone like Prednisolone) could contribute to a shift towards type 2 cytokine production, which is associated with HIV infection. Therefore, reducing cortisol levels (or mimicking this effect with Prednisolone) could potentially prevent this shift and thus inflammation associated with HIV infection. However, this is a complex biological process, and further research would be needed to confirm this hypothesis." -18452194,Prednisolone exacerbates ulcerative colitis,342,CONCLUSIONS: This study suggests that 24 h urinary free cortisol could be considered as a potential index of adrenal cortisol production in patients with liver cirrhosis and it potentially detects patients with a high mortality risk.,False,Is the triple 'Prednisolone exacerbates ulcerative colitis' supported by the sentence: 'CONCLUSIONS: This study suggests that 24 h urinary free cortisol could be considered as a potential index of adrenal cortisol production in patients with liver cirrhosis and it potentially detects patients with a high mortality risk.'?,"No, this sentence does not indirectly support the statement ""Prednisolone exacerbates ulcerative colitis"". The sentence is discussing a study about using 24-hour urinary free cortisol as an index for adrenal cortisol production in patients with liver cirrhosis, which may help detect patients at high mortality risk. Prednisolone is a synthetic glucocorticoid used in various inflammatory conditions, but there is no direct connection mentioned between prednisolone, urinary free cortisol, liver cirrhosis, and ulcerative colitis in this statement to support the initial claim." -25753407,Prednisolone predisposes neoplasm,343,Congenital adrenal hyperplasia (CAH) is an autosomal recessive disorder that leads to the partial or complete deficiency of cortisol and aldosterone production from the adrenal glands.,False,Is the triple 'Prednisolone predisposes neoplasm' supported by the sentence: 'Congenital adrenal hyperplasia (CAH) is an autosomal recessive disorder that leads to the partial or complete deficiency of cortisol and aldosterone production from the adrenal glands.'?,"No, this sentence does not indirectly support the statement that Prednisolone predisposes neoplasm through congenital adrenal hyperplasia (CAH). The sentence only describes CAH as an autosomal recessive disorder leading to cortisol and aldosterone deficiency, but it does not mention Prednisolone, neoplasms, or any relationship between them." -16546227,Prednisolone predisposes pneumonia,344,[Reaction of autogenous cortisol production in patients with extensive psoriasis vulgaris or atopic dermatitis following external administration of a 0.25% prednicarbate salve (W/O emulsion)].,False,Is the triple 'Prednisolone predisposes pneumonia' supported by the sentence: '[Reaction of autogenous cortisol production in patients with extensive psoriasis vulgaris or atopic dermatitis following external administration of a 0.25% prednicarbate salve (W/O emulsion)].'?,"No, this sentence does not provide indirect support for the statement ""Prednisolone predisposes pneumonia."" The sentence discusses the reaction of autogenous cortisol production in patients with extensive psoriasis vulgaris or atopic dermatitis following external administration of a 0.25% prednicarbate salve, which is not related to pneumonia or Prednisolone. Prednicarbate is a type of corticosteroid, similar to Prednisolone, but it is not the same compound, and it is used topically, not systemically like Prednisolone. Therefore, there is no connection between the two statements." -27027571,Hydrocortisone related to HIV infectious disease,345,"OBJECTIVE: Corticosteroid-binding globulin (CBG), the cortisol transport protein, is cleaved from high-affinity (haCBG) to low-affinity (laCBG) CBG at sites of inflammation releasing bioavailable, anti-inflammatory cortisol.",True,"Is the triple 'Hydrocortisone related to HIV infectious disease' supported by the sentence: 'OBJECTIVE: Corticosteroid-binding globulin (CBG), the cortisol transport protein, is cleaved from high-affinity (haCBG) to low-affinity (laCBG) CBG at sites of inflammation releasing bioavailable, anti-inflammatory cortisol.'?","Yes, there is an indirect relationship between Hydrocortisone (a type of corticosteroid) and HIV infectious disease as suggested by the sentence. The sentence discusses how corticosteroid-binding globulin (CBG) is cleaved at sites of inflammation, releasing bioavailable, anti-inflammatory cortisol which is a type of corticosteroid, including Hydrocortisone, acting as an immunosuppressant, potentially affecting the immune response in an indirect way during an HIV infection, which is characterized by chronic inflammation. However, it is important to note that this is an indirect relationship, as it involves complex interactions within the immune system, which may not be directly linked to Hydrocortisone itself, but through its role as an immunosuppressant." -25927636,Hydrocortisone related to cardiac arrest,346,The propensity to develop type 1 diabetes or type 2 diabetes/metabolic syndrome depends on the propensity to release of cortisol which correlates with race.,False,Is the triple 'Hydrocortisone related to cardiac arrest' supported by the sentence: 'The propensity to develop type 1 diabetes or type 2 diabetes/metabolic syndrome depends on the propensity to release of cortisol which correlates with race.'?,"No, this sentence does not provide any direct or indirect support for the idea that hydrocortisone is related to cardiac arrest. The sentence discusses the relationship between race, cortisol release, and the propensity to develop type 1 diabetes or type 2 diabetes/metabolic syndrome, but it does not mention hydrocortisone or cardiac arrest. Hydrocortisone is a synthetic form of cortisol, but without further information, there is no clear connection between this sentence and the proposed relationship between hydrocortisone and cardiac arrest." -25797574,Hydrocortisone related to lymphoma,347,"CIRCI is characterized by an inadequate production of cortisol in relation to an increased demand during periods of severe stress, particularly in critical illnesses such as sepsis or septic shock.",True,"Is the triple 'Hydrocortisone related to lymphoma' supported by the sentence: 'CIRCI is characterized by an inadequate production of cortisol in relation to an increased demand during periods of severe stress, particularly in critical illnesses such as sepsis or septic shock.'?","Yes, there is indirect support for the connection between hydrocortisone, which is a form of cortisol, and lymphoma in this sentence. The sentence discusses CIRCI (Critical Illness-Related Corticosteroid Insufficiency), a condition characterized by an inadequate production of cortisol during periods of severe stress, particularly in critical illnesses such as sepsis or septic shock. Hydrocortisone is often used in medical settings as a replacement for cortisol in such conditions, as it has similar anti-inflammatory effects and can help manage symptoms. - - Now, regarding lymphoma, it is a type of cancer that affects the immune system, including white blood cells (lymphocytes) which can be impacted by corticosteroids like hydrocortisone due to their immunosuppressive properties. This immunosuppression can potentially influence the progression, treatment, or symptoms experienced in certain types of lymphoma, providing an indirect link between hydrocortisone and this form of cancer. However, it is essential to note this connection is not direct, as hydrocortisone" -25131277,Hydrocortisone related to Crohn disease,348,Synacthen test diagnosed Addison's disease with a clear deficiency of cortisol production.,False,Is the triple 'Hydrocortisone related to Crohn disease' supported by the sentence: 'Synacthen test diagnosed Addison's disease with a clear deficiency of cortisol production.'?,"No, this sentence does not provide any indirect evidence that hydrocortisone is related to Crohn's disease. The sentence only mentions Addison's disease, which is a different medical condition characterized by deficiency in cortisol production, and Synacthen test, which is used for diagnosing Addison's disease. Hydrocortisone is a medication used for treating Addison's disease, but there is no mention of its relation to Crohn's disease in this sentence." -19793698,Hydrocortisone related to alcohol abuse,349,"Enhanced cortisol production rates, free cortisol, and 11beta-HSD-1 expression correlate with visceral fat and insulin resistance in men: effect of weight loss.",False,"Is the triple 'Hydrocortisone related to alcohol abuse' supported by the sentence: 'Enhanced cortisol production rates, free cortisol, and 11beta-HSD-1 expression correlate with visceral fat and insulin resistance in men: effect of weight loss.'?","No, this sentence does not support a direct link between hydrocortisone and alcohol abuse. The sentence discusses the correlation between enhanced cortisol production rates, free cortisol, 11beta-HSD-1 expression, visceral fat, and insulin resistance in men, particularly in relation to weight loss. Hydrocortisone is a type of corticosteroid hormone produced by the adrenal gland, which plays a role in regulating stress response, metabolism, and immune response, among other functions, so there is an indirect connection through cortisol, but not specifically in relation to alcohol abuse." -19531872,Hydrocortisone related to atrial fibrillation,350,"Obesity is also related to dysregulation of cortisol production by the pre-receptor enzyme, 11beta-hydroxysteroid dehydrogenase, and we speculate that this may have a role in the pathogenesis of obesity and raised ICP seen in IIH.",True,"Is the triple 'Hydrocortisone related to atrial fibrillation' supported by the sentence: 'Obesity is also related to dysregulation of cortisol production by the pre-receptor enzyme, 11beta-hydroxysteroid dehydrogenase, and we speculate that this may have a role in the pathogenesis of obesity and raised ICP seen in IIH.'?","Yes, there is an indirect relationship between Hydrocortisone and atrial fibrillation in the context of the sentence provided. Hydrocortisone is a type of corticosteroid, which is closely related to cortisol, a hormone produced by the adrenal gland. The sentence mentions obesity being associated with dysregulation of cortisol production, which could potentially lead to conditions like obesity and idiopathic intracranial hypertension (IIH). - - While not explicitly mentioned, there is evidence linking obesity and atrial fibrillation [1]. In this regard, Hydrocortisone could be indirectly linked to atrial fibrillation through its association with obesity due to cortisol dysregulation. However, it is important to note that this is speculative, as further research would be required to establish this relationship conclusively. - - [1] - Poirier, P., et al. (2006). Obesity and cardiovascular disease: pathophysiology, evaluation, and effect of weight loss: an update of the 199" -18705900,Hydrocortisone related to phobic disorder,351,"This is an extremely rare case of bilateral adrenal tumors, in which the left adrenocortical tumor produced and secreted cortisol or both cortisol and aldosterone and the right one produced and secreted both aldosterone and cortisol, as confirmed by clinical findings and pathological studies using immunohistochemical analysis.",False,"Is the triple 'Hydrocortisone related to phobic disorder' supported by the sentence: 'This is an extremely rare case of bilateral adrenal tumors, in which the left adrenocortical tumor produced and secreted cortisol or both cortisol and aldosterone and the right one produced and secreted both aldosterone and cortisol, as confirmed by clinical findings and pathological studies using immunohistochemical analysis.'?","No, this sentence does not provide any indirect support for a relationship between Hydrocortisone and phobic disorder. The sentence discusses an extremely rare case of bilateral adrenal tumors, detailing their production and secretion of cortisol and aldosterone, which is then confirmed through clinical findings and pathological studies using immunohistochemical analysis. However, it does not mention anything about Hydrocortisone being linked to any kind of disorder, let alone a phobic disorder." -15155784,Hydrocortisone related to psoriasis,352,"We conclude that the clinical picture of late-onset adrenal insufficiency in preterm infants is not a result of an absolute deficiency of cortisol production, but may be a result of a limited ability to synthesize sufficient cortisol for the degree of clinical stress.",False,"Is the triple 'Hydrocortisone related to psoriasis' supported by the sentence: 'We conclude that the clinical picture of late-onset adrenal insufficiency in preterm infants is not a result of an absolute deficiency of cortisol production, but may be a result of a limited ability to synthesize sufficient cortisol for the degree of clinical stress.'?","No, this sentence does not provide support for the relationship between hydrocortisone and psoriasis. The sentence discusses late-onset adrenal insufficiency in preterm infants, which is related to cortisol production, not hydrocortisone, which is a synthetic form of cortisol often used in treatments for various conditions, including some forms of psoriasis. However, this sentence does not mention nor imply any connection between hydrocortisone and psoriasis, thus it does not support the triple relationship indirectly." -14891361,"Hydrocortisone related to dermatitis, atopic",353,"Ironically, despite our understanding of the various stressors that promote chronic adult-onset asthma, most of which are known to elevate cortisol production via the hypothalamic-pituitary-adrenal (HPA) axis, inhaled and systemic corticosteroids are the mainstay for the treatment of chronic asthma.",True,"Is the triple 'Hydrocortisone related to dermatitis, atopic' supported by the sentence: 'Ironically, despite our understanding of the various stressors that promote chronic adult-onset asthma, most of which are known to elevate cortisol production via the hypothalamic-pituitary-adrenal (HPA) axis, inhaled and systemic corticosteroids are the mainstay for the treatment of chronic asthma.'?","Yes, this sentence does indirectly support the idea that hydrocortisone, which is a type of corticosteroid, is related to atopic dermatitis, as both conditions involve cortisol production via the HPA axis. While the sentence primarily discusses corticosteroids in relation to asthma, it mentions stressors which promote chronic adult-onset asthma, which can lead to elevated cortisol production, thus implicating hydrocortisone in both conditions. Therefore, it can be inferred that hydrocortisone may have an impact on atopic dermatitis, given its role in cortisol production, which is relevant for both asthma and atopic dermatitis management." -14483328,Hydrocortisone related to bronchopulmonary dysplasia,354,Glucocorticoid insufficiency is common during sepsis and may result from insufficient production of cortisol or peripheral tissues resistance.,True,Is the triple 'Hydrocortisone related to bronchopulmonary dysplasia' supported by the sentence: 'Glucocorticoid insufficiency is common during sepsis and may result from insufficient production of cortisol or peripheral tissues resistance.'?,"Yes, the sentence does indirectly support a relationship between hydrocortisone (a glucocorticoid) and bronchopulmonary dysplasia (BPD). This is because BPD is often associated with sepsis, which can lead to glucocorticoid insufficiency due to insufficient cortisol production or peripheral tissues resistance. Hydrocortisone, as a glucocorticoid, could potentially be used to treat this insufficiency, thereby indirectly impacting BPD. However, this is a complex relationship and further research would be needed to fully understand it." -14450267,Hydrocortisone related to adrenal cortex neoplasm,355,"This likely represents an adaptive response to LTH, to prevent excessive cortisol production that would restrict fetal growth and potentially induce preterm delivery.",True,"Is the triple 'Hydrocortisone related to adrenal cortex neoplasm' supported by the sentence: 'This likely represents an adaptive response to LTH, to prevent excessive cortisol production that would restrict fetal growth and potentially induce preterm delivery.'?","Yes, there is indirect support for this statement in the given sentence. Hydrocortisone is a type of corticosteroid, which is produced in the adrenal cortex. The sentence suggests that a decrease in corticosteroid production (represented here as LTH, which stands for low-dose hydrocortisone therapy) is an adaptive response to prevent excessive cortisol production, which could restrict fetal growth and potentially induce preterm delivery. Therefore, there is an indirect relationship between hydrocortisone (a product of the adrenal cortex) and adrenal cortex neoplasm, as changes in corticosteroid production can have significant effects on fetal development, as mentioned in the sentence." -14387016,Hydrocortisone related to cirrhosis of liver,356,"The reduction in local cortisol production which diminishes the endogenous anti-inflammatory effects, also allows for the progression of both vascular and pulmonary inflammation.",False,"Is the triple 'Hydrocortisone related to cirrhosis of liver' supported by the sentence: 'The reduction in local cortisol production which diminishes the endogenous anti-inflammatory effects, also allows for the progression of both vascular and pulmonary inflammation.'?","No, this sentence does not provide any direct or indirect support for a relationship between hydrocortisone and liver cirrhosis. The sentence discusses the role of cortisol (which hydrocortisone can mimic) in inflammation, particularly vascular and pulmonary inflammation, but it does not mention or imply any connection to liver cirrhosis." -14360687,Hydrocortisone related to dermatitis,357,"CONCLUSIONS: Patients with newly diagnosed, untreated PC yielded significantly higher cortisol and lower estradiol serum concentrations than controls.",False,"Is the triple 'Hydrocortisone related to dermatitis' supported by the sentence: 'CONCLUSIONS: Patients with newly diagnosed, untreated PC yielded significantly higher cortisol and lower estradiol serum concentrations than controls.'?","No, this sentence does not provide support for a relationship between hydrocortisone and dermatitis. The sentence discusses cortisol serum concentrations in patients with prostate cancer (PC) compared to controls, not hydrocortisone or dermatitis. Hydrocortisone is a synthetic form of cortisol, but no mention is made of its relation to dermatitis in this sentence." -13844584,Hydrocortisone related to acute myeloid leukemia,358,"The tumour secreted excessive cortisol and dehydroepiandrosterone-sulphate (DHEA-S), and had invaded the right hepatic lobe and vena cava.",True,"Is the triple 'Hydrocortisone related to acute myeloid leukemia' supported by the sentence: 'The tumour secreted excessive cortisol and dehydroepiandrosterone-sulphate (DHEA-S), and had invaded the right hepatic lobe and vena cava.'?","Yes, there is indirect support for this statement. Hydrocortisone is also known as cortisol, which is mentioned in the sentence as being secreted excessively by the tumor. Acute myeloid leukemia (AML) is known to cause excessive cortisol production, among other hormones, due to involvement of the adrenal glands, where cortisol is primarily produced in the body. However, this statement does not directly link hydrocortisone (or cortisol) specifically to AML, as there can be other conditions leading to increased cortisol levels as well, such as Cushing’s syndrome, adrenal tumors, etc." -13213365,Hydrocortisone related to chronic primary adrenal insufficiency,359,Replacement doses of hydrocortisone were administered throughout treatment to counteract potential adrenal insufficiency secondary to the ketoconazole.,True,Is the triple 'Hydrocortisone related to chronic primary adrenal insufficiency' supported by the sentence: 'Replacement doses of hydrocortisone were administered throughout treatment to counteract potential adrenal insufficiency secondary to the ketoconazole.'?,"Yes, there is indirect evidence supporting the association between hydrocortisone and chronic primary adrenal insufficiency in this sentence. Ketoconazole is known to inhibit steroidogenesis, which can lead to secondary adrenal insufficiency. The mention of administering hydrocortisone throughout treatment suggests an awareness of potential adrenal insufficiency, which could be either secondary (as mentioned) or primary, given its role as a replacement therapy for adrenal insufficiency regardless of cause. However, it does not directly state an association between hydrocortisone and primary adrenal insufficiency in this context." -12756660,Hydrocortisone related to borderline personality disorder,360,Amplication by hydrocortisone of the induction of cytotoxic response in vitro to syngeneic murine leukemias.,False,Is the triple 'Hydrocortisone related to borderline personality disorder' supported by the sentence: 'Amplication by hydrocortisone of the induction of cytotoxic response in vitro to syngeneic murine leukemias.'?,"No, this sentence does not provide any support for a relationship between hydrocortisone and borderline personality disorder. The sentence discusses the effects of hydrocortisone on inducing cytotoxic responses in vitro to syngeneic murine leukemias, which is not relevant to mental health disorders like borderline personality disorder." -12576998,Hydrocortisone related to Hypoxemia,361,The results demonstrated that the intrarectal dose of indomethacin and hydrocortisone inhibited the development of tumors from microscopic carcinoma lesions in the large bowel and growing further.,False,Is the triple 'Hydrocortisone related to Hypoxemia' supported by the sentence: 'The results demonstrated that the intrarectal dose of indomethacin and hydrocortisone inhibited the development of tumors from microscopic carcinoma lesions in the large bowel and growing further.'?,"No, the sentence does not provide support for a relationship between hydrocortisone and hypoxemia, let alone hypoxemia being an indirect consequence of hydrocortisone use. The sentence only discusses the inhibitory effect of indomethacin and hydrocortisone on tumor development in the large bowel, which does not imply any connection to hypoxemia, which is defined as lower-than-normal levels of oxygen in the blood." -11888652,Hydrocortisone related to congenital adrenal hyperplasia,362,"Growth of ovarian, lung, breast, and kidney carcinomas was increased by 136%, 126%, 78% and 69%, respectively, whereas melanomas, sarcomas, and colon tumors were inhibited by hydrocortisone.",False,"Is the triple 'Hydrocortisone related to congenital adrenal hyperplasia' supported by the sentence: 'Growth of ovarian, lung, breast, and kidney carcinomas was increased by 136%, 126%, 78% and 69%, respectively, whereas melanomas, sarcomas, and colon tumors were inhibited by hydrocortisone.'?","No, this sentence does not provide support for a relationship between hydrocortisone and congenital adrenal hyperplasia (CAH). The sentence only mentions the effects of hydrocortisone on various types of carcinomas and tumors, but it does not mention anything about CAH, which is a genetic disorder affecting the adrenal glands. Therefore, we cannot infer any relationship based on this sentence alone." -11866289,Hydrocortisone related to nicotine dependence,363,Insufficient cortisol limits the ability of the sick newborn to handle stress and inhibit pulmonary inflammation.,False,Is the triple 'Hydrocortisone related to nicotine dependence' supported by the sentence: 'Insufficient cortisol limits the ability of the sick newborn to handle stress and inhibit pulmonary inflammation.'?,"No, this sentence does not provide indirect evidence for a relationship between hydrocortisone and nicotine dependence. The sentence discusses cortisol, which is a hormone produced in response to stress, rather than hydrocortisone, which is a synthetic form of cortisol used in medical treatment. Moreover, it discusses cortisol levels in newborns, not in individuals experiencing nicotine dependence. Hydrocortisone might be used in treating certain conditions associated with nicotine dependence, such as depression, but this sentence does not provide evidence for such a link." -11530989,Hydrocortisone related to pneumonia,364,"BACKGROUND: Hepatic 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) activity, which converts cortisone (inactive) to cortisol, is downregulated in obesity.",False,"Is the triple 'Hydrocortisone related to pneumonia' supported by the sentence: 'BACKGROUND: Hepatic 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) activity, which converts cortisone (inactive) to cortisol, is downregulated in obesity.'?","No, this sentence does not provide indirect evidence for a relationship between hydrocortisone and pneumonia. The sentence discusses 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) activity, which is involved in converting cortisone (inactive) to cortisol, but it does not mention hydrocortisone specifically, nor does it mention pneumonia. Hydrocortisone is a synthetic version of cortisol, but without explicit mention, we cannot infer any relationship based on this sentence alone." -11442939,Hydrocortisone related to prostate cancer,365,"High-dose hydrocortisone treatment given in the first few hours after a traumatic experience was associated with significant favorable changes in the trajectory of exposure to trauma, as expressed by the reduced risk of the development of PTSD post-trauma.",False,"Is the triple 'Hydrocortisone related to prostate cancer' supported by the sentence: 'High-dose hydrocortisone treatment given in the first few hours after a traumatic experience was associated with significant favorable changes in the trajectory of exposure to trauma, as expressed by the reduced risk of the development of PTSD post-trauma.'?","No, this sentence does not provide evidence for an indirect relationship between hydrocortisone and prostate cancer. The sentence discusses the association between high-dose hydrocortisone treatment and the reduced risk of post-traumatic stress disorder (PTSD) after a traumatic experience, not prostate cancer." -11089023,Hydrocortisone related to pancreatitis,366,"Under normal conditions, stress induces increased cortisol secretion that counteracts inflammatory reactions.",True,"Is the triple 'Hydrocortisone related to pancreatitis' supported by the sentence: 'Under normal conditions, stress induces increased cortisol secretion that counteracts inflammatory reactions.'?","Yes, the statement is indirectly supported by this sentence. Hydrocortisone is a synthetic form of cortisol, which is often referred to as the body's natural stress hormone. Cortisol, including synthetic forms like hydrocortisone, helps to counteract inflammatory reactions in the body. Pancreatitis is an inflammatory condition of the pancreas, so it is plausible that increased cortisol secretion could theoretically help to counteract this inflammation, thereby having an indirect relationship. However, it is important to note that this is a simplified explanation, and in reality, the relationship between stress, cortisol, and inflammatory conditions like pancreatitis is complex and can depend on many factors, including dosage, duration, and individual health conditions." -10649902,Hydrocortisone related to myocardial infarction,367,Hydrocortisone (HC) reduced the macrophage content of four murine tumors to less than half of control values.,False,Is the triple 'Hydrocortisone related to myocardial infarction' supported by the sentence: 'Hydrocortisone (HC) reduced the macrophage content of four murine tumors to less than half of control values.'?,"No, this sentence does not provide any direct or indirect support for the relationship between Hydrocortisone (HC) and myocardial infarction. The sentence only mentions the effect of HC on reducing macrophage content in four murine tumors, which is unrelated to myocardial infarction." -10522181,Hydrocortisone related to osteoarthritis,368,"Further, because infant formula contains only trace amounts of glucocorticoids, these findings suggest that cortisol in milk is a novel biological pathway through which breastfeeding may protect against later obesity.",False,"Is the triple 'Hydrocortisone related to osteoarthritis' supported by the sentence: 'Further, because infant formula contains only trace amounts of glucocorticoids, these findings suggest that cortisol in milk is a novel biological pathway through which breastfeeding may protect against later obesity.'?","No, this sentence does not provide support for the idea that hydrocortisone is related to osteoarthritis, either directly or indirectly. The sentence discusses the potential relationship between cortisol in milk (a type of glucocorticoid) and obesity, but it does not mention hydrocortisone specifically, nor does it mention osteoarthritis at all." -10521296,Hydrocortisone related to eye disorder,369,"Conclusions and Relevance: Among adults with severe sepsis not in septic shock, use of hydrocortisone compared with placebo did not reduce the risk of septic shock within 14 days.",False,"Is the triple 'Hydrocortisone related to eye disorder' supported by the sentence: 'Conclusions and Relevance: Among adults with severe sepsis not in septic shock, use of hydrocortisone compared with placebo did not reduce the risk of septic shock within 14 days.'?","No, this sentence does not provide any indirect support for a relationship between hydrocortisone use and an increased risk for an eye disorder. The sentence discusses the use of hydrocortisone in adults with severe sepsis, not an eye disorder, and it focuses on the risk of septic shock within 14 days, not any potential ocular side effects." -10518203,Hydrocortisone related to otitis externa,370,These findings suggest that HC may protect against hyperoxic injury in the developing pulmonary vasculature.,False,Is the triple 'Hydrocortisone related to otitis externa' supported by the sentence: 'These findings suggest that HC may protect against hyperoxic injury in the developing pulmonary vasculature.'?,"No, this sentence does not provide any indirect support for the idea that Hydrocortisone (HC) is related to otitis externa, an outer ear infection. The sentence discusses the potential protective effects of HC against hyperoxic injury in the developing pulmonary vasculature, which is unrelated to otitis externa." -10484611,Hydrocortisone related to ulcerative colitis,371,OBJECTIVE: Cortisol clearance is reduced in sepsis and may contribute to the development of impaired adrenocortical function that is thought to contribute to the pathophysiology of critical illness-related corticosteroid insufficiency.,True,Is the triple 'Hydrocortisone related to ulcerative colitis' supported by the sentence: 'OBJECTIVE: Cortisol clearance is reduced in sepsis and may contribute to the development of impaired adrenocortical function that is thought to contribute to the pathophysiology of critical illness-related corticosteroid insufficiency.'?,"Yes, this sentence can indirectly support the connection between Hydrocortisone (a synthetic form of Cortisol) and ulcerative colitis, as it suggests that impaired adrenocortical function, which can be influenced by Cortisol levels, may contribute to critical illness-related corticosteroid insufficiency, which is often treated with Hydrocortisone in conditions like ulcerative colitis." -9718673,Hydrocortisone related to atopic eczema,372,Hydrocortisone therapy was started to prevent adrenal insufficiency before laboratory findings for ACTH (adrenocorticotropic hormone) and cortisol levels.,True,Is the triple 'Hydrocortisone related to atopic eczema' supported by the sentence: 'Hydrocortisone therapy was started to prevent adrenal insufficiency before laboratory findings for ACTH (adrenocorticotropic hormone) and cortisol levels.'?,"Yes, this sentence does indirectly support the idea that hydrocortisone is related to atopic eczema. The sentence mentions hydrocortisone therapy, which is often used as a treatment for various inflammatory skin conditions, including atopic dermatitis (eczema). The therapy is being used here to prevent adrenal insufficiency, which could be a complication due to long-term use of corticosteroids like hydrocortisone. So, while the sentence doesn't directly mention atopic eczema, it does imply a connection between hydrocortisone and skin conditions." -9492934,Hydrocortisone related to opiate dependence,373,CONCLUSION: We conclude that intravenous stress doses of hydrocortisone lead to a reduction of systemic inflammation and to a potential improvement in the early outcome of patients undergoing off-pump CABG.,False,Is the triple 'Hydrocortisone related to opiate dependence' supported by the sentence: 'CONCLUSION: We conclude that intravenous stress doses of hydrocortisone lead to a reduction of systemic inflammation and to a potential improvement in the early outcome of patients undergoing off-pump CABG.'?,"No, this sentence does not provide any support for a relationship between hydrocortisone and opiate dependence. The sentence discusses the effects of intravenous stress doses of hydrocortisone on systemic inflammation and early outcomes in patients undergoing off-pump coronary artery bypass graft (CABG) surgery, but it does not mention anything about opiate dependence." -9238280,Hydrocortisone related to Sepsis,374,"CONCLUSION: In intubated trauma patients, the use of an intravenous stress-dose of hydrocortisone, compared with placebo, resulted in a decreased risk of hospital-acquired pneumonia.",True,"Is the triple 'Hydrocortisone related to Sepsis' supported by the sentence: 'CONCLUSION: In intubated trauma patients, the use of an intravenous stress-dose of hydrocortisone, compared with placebo, resulted in a decreased risk of hospital-acquired pneumonia.'?","Yes, there is indirect support for this statement. Hydrocortisone is an intravenous stress-dose steroid, which can help regulate the immune response in critically ill patients, such as those with sepsis. The sentence in question mentions its use in intubated trauma patients, which can include those with sepsis, leading to decreased hospital-acquired pneumonia risk, an infection commonly seen in sepsis patients due to weakened immune systems. Therefore, hydrocortisone could have an indirect effect on sepsis via immune system regulation, leading to reduced infection risk, as suggested in this sentence." -9235597,Hydrocortisone related to type 1 diabetes mellitus,375,"Early hydrocortisone (HC) treatment may decrease the incidence of bronchopulmonary dysplasia; however, the long-term effects are still under evaluation.",False,"Is the triple 'Hydrocortisone related to type 1 diabetes mellitus' supported by the sentence: 'Early hydrocortisone (HC) treatment may decrease the incidence of bronchopulmonary dysplasia; however, the long-term effects are still under evaluation.'?","No, this sentence does not provide any direct or indirect support for a relationship between hydrocortisone and type 1 diabetes mellitus. The sentence discusses the use of hydrocortisone in relation to bronchopulmonary dysplasia, not diabetes." -8977987,Hydrocortisone related to injury,376,CONCLUSION: Intravenous hydrocortisone reduced the incidence of AF after cardiac surgery.,True,Is the triple 'Hydrocortisone related to injury' supported by the sentence: 'CONCLUSION: Intravenous hydrocortisone reduced the incidence of AF after cardiac surgery.'?,"Yes, there is indirect support for this statement. The sentence suggests that hydrocortisone, when administered intravenously, can reduce the incidence of atrial fibrillation (AF) after cardiac surgery. This implies that hydrocortisone might have some protective effect or influence on the post-surgical recovery process, which could include reducing inflammation or stress responses associated with injury. However, it's important to note that this is an indirect inference, as the sentence does not explicitly state that hydrocortisone is directly linked to injury reduction." -8778414,Hydrocortisone related to Inflammation,377,"Assuming a single dose of hydrocortisone improves sensitivity of peripheral tissues to insulin, it may be an interesting candidate for use in reducing insulin resistance in peripheral tissues of horses with several disease states.",True,"Is the triple 'Hydrocortisone related to Inflammation' supported by the sentence: 'Assuming a single dose of hydrocortisone improves sensitivity of peripheral tissues to insulin, it may be an interesting candidate for use in reducing insulin resistance in peripheral tissues of horses with several disease states.'?","Yes, this sentence does indirectly support the idea that hydrocortisone is related to inflammation. Hydrocortisone is a type of corticosteroid, which is often used to reduce inflammation in the body. The sentence mentions that hydrocortisone can improve sensitivity of peripheral tissues to insulin, which is a factor in several disease states, including inflammatory ones. Therefore, by improving insulin sensitivity, hydrocortisone could potentially help reduce inflammation in these diseases. However, this is an indirect relationship and further research would be needed to confirm this hypothesis." -8763179,Hydrocortisone related to toxic shock syndrome,378,Plasma cortisol and glucagon concentrations were not increased markedly except in a case complicated other systemic bacterial infection.,False,Is the triple 'Hydrocortisone related to toxic shock syndrome' supported by the sentence: 'Plasma cortisol and glucagon concentrations were not increased markedly except in a case complicated other systemic bacterial infection.'?,"No, this sentence does not provide support for a relationship between hydrocortisone and toxic shock syndrome. The sentence only mentions that plasma cortisol concentrations were not increased markedly in most cases, except in one case complicated by other systemic bacterial infection. Hydrocortisone is a synthetic form of cortisol, a hormone produced naturally in the body, so it is not directly addressed in this statement. Furthermore, there is no mention of toxic shock syndrome in this sentence, which is a systemic inflammatory response typically caused by certain bacterial infections, not corticosteroids like hydrocortisone." -8625521,Hydrocortisone related to dissociative amnesia,379,"In view of the stimulatory effects of insulin and cortisol on adipogenesis, long-term stimulation of 11betaHSD reductase activity by insulin could aggravate visceral obesity.",False,"Is the triple 'Hydrocortisone related to dissociative amnesia' supported by the sentence: 'In view of the stimulatory effects of insulin and cortisol on adipogenesis, long-term stimulation of 11betaHSD reductase activity by insulin could aggravate visceral obesity.'?","No, this sentence does not provide indirect support for the idea that hydrocortisone is related to dissociative amnesia. The sentence discusses the relationship between insulin, cortisol, and visceral obesity, but it does not mention hydrocortisone or any conditions related to amnesia, such as dissociative amnesia. Hydrocortisone is a type of corticosteroid hormone, but it is not directly mentioned in this sentence, so there is no implicit connection between hydrocortisone and dissociative amnesia in this context." -8615164,Hydrocortisone related to asthma,380,"For this purpose, this review article contends that plasma cortisol is linked to a greater risk of AF.",False,"Is the triple 'Hydrocortisone related to asthma' supported by the sentence: 'For this purpose, this review article contends that plasma cortisol is linked to a greater risk of AF.'?","No, this sentence does not provide any support for the claim that Hydrocortisone is linked to asthma, directly or indirectly. The sentence discusses a link between plasma cortisol and atrial fibrillation (AF), not asthma. Hydrocortisone is a synthetic form of cortisol, but this sentence does not make any connection between cortisol, Hydrocortisone, and asthma." -8570630,Hydrocortisone related to fibromyalgia,381,"After multivariate analysis, duration of HC stress dose administration was associated with increased risk of mortality (OR 1.11, 95% CI 1.02-1.2, p = 0.021), and total duration of HC treatment was associated with increased risk of sepsis (OR 1.04, 95% CI 1.005-1.075, p = 0.026).",False,"Is the triple 'Hydrocortisone related to fibromyalgia' supported by the sentence: 'After multivariate analysis, duration of HC stress dose administration was associated with increased risk of mortality (OR 1.11, 95% CI 1.02-1.2, p = 0.021), and total duration of HC treatment was associated with increased risk of sepsis (OR 1.04, 95% CI 1.005-1.075, p = 0.026).'?","No, this sentence does not provide any direct or indirect evidence for a relationship between Hydrocortisone (HC) and fibromyalgia. This sentence discusses the risks associated with the duration of HC stress dose administration and total duration of HC treatment, but it does not mention fibromyalgia." -8017438,Hydrocortisone related to Insulin resistance,382,"Plasma leptin and ghrelin levels in endotoxin-treated dogs were correlated with serum nitric oxide (r = .955 and r = .890; p < .001), procalcitonin (r = .825 and r = .716; p < .001), cortisol (r = .823 and r = .786; p < .001), and hepatorenal injury markers (r = .580 to .745 and r = .393 to .574; p < .05 to .01).",False,"Is the triple 'Hydrocortisone related to Insulin resistance' supported by the sentence: 'Plasma leptin and ghrelin levels in endotoxin-treated dogs were correlated with serum nitric oxide (r = .955 and r = .890; p < .001), procalcitonin (r = .825 and r = .716; p < .001), cortisol (r = .823 and r = .786; p < .001), and hepatorenal injury markers (r = .580 to .745 and r = .393 to .574; p < .05 to .01).'?","No, this sentence does not directly support the idea that Hydrocortisone is related to Insulin resistance. This sentence discusses correlations between various markers in endotoxin-treated dogs, including cortisol, but it does not mention Hydrocortisone or Insulin resistance. Hydrocortisone is a synthetic form of cortisol, but this sentence does not provide enough information to make a direct correlation between Hydrocortisone and Insulin resistance." -7919367,Hydrocortisone related to adrenocortical insufficiency,383,Contribution of cortisol deficiency to septic shock.,True,Is the triple 'Hydrocortisone related to adrenocortical insufficiency' supported by the sentence: 'Contribution of cortisol deficiency to septic shock.'?,"Yes, there is an indirect relationship between Hydrocortisone and adrenocortical insufficiency in relation to septic shock, as suggested in the sentence. Hydrocortisone is a synthetic form of cortisol, which is a hormone produced by the adrenal glands as part of the body’s response to stress, including septic shock. In cases of adrenocortical insufficiency (also known as Addison’s disease), the body does not produce enough cortisol, making it challenging for individuals to respond effectively to stressful situations, including septic shock. Therefore, administering hydrocortisone in such cases could help manage symptoms associated with septic shock, providing indirect evidence for their relationship." -7573954,Hydrocortisone related to neoplasm,384,The objective of this study was to demonstrate the effect of stress doses of hydrocortisone during the initial phase of human septic shock on the serum values of the neurospecific protein S-100B in comparison to the inflammation markers interleukin (IL)-8 in serum and polymorphonuclear (PMN) elastase in plasma.,False,Is the triple 'Hydrocortisone related to neoplasm' supported by the sentence: 'The objective of this study was to demonstrate the effect of stress doses of hydrocortisone during the initial phase of human septic shock on the serum values of the neurospecific protein S-100B in comparison to the inflammation markers interleukin (IL)-8 in serum and polymorphonuclear (PMN) elastase in plasma.'?,"No, this sentence does not provide support for a direct relationship between hydrocortisone and neoplasm. The study is focused on the effects of hydrocortisone during septic shock and its relationship with certain serum values, not on its relation to neoplasms." -7182905,Hydrocortisone related to obesity disorder,385,"The synergism between insulin and cortisol in stimulating energy deposition, associated with a decreased effect of corticotropin-releasing factor in stimulating energy expenditure, is likely to contribute to the development of obesity.",True,"Is the triple 'Hydrocortisone related to obesity disorder' supported by the sentence: 'The synergism between insulin and cortisol in stimulating energy deposition, associated with a decreased effect of corticotropin-releasing factor in stimulating energy expenditure, is likely to contribute to the development of obesity.'?","Yes, there is indirect support for this statement in the given sentence. Hydrocortisone is a type of corticosteroid, which is involved in regulating metabolism, among other things, through its role as a hormonal precursor in cortisol production (a type of glucocorticoid). Glucocorticoids, such as cortisol, have been associated with weight gain, insulin resistance, and other metabolic disturbances when present in excess, such as in Cushing syndrome. The sentence provided discusses how cortisol, in combination with insulin, can contribute to energy deposition, which may lead to weight gain (or in this case, obesity) when there is an imbalance between energy intake (stimulated by insulin) and energy expenditure (inhibited by corticotropin-releasing factor). Therefore, hydrocortisone could be indirectly linked through its role in cortisol regulation, which in turn is connected to insulin-mediated energy deposition in the context of obesity development as described in the sentence." -24445107,Hydrocortisone related to Inflammation,386,Higher basal cortisol predicts verbal memory loss in postmenopausal women: Rancho Bernardo Study.,True,Is the triple 'Hydrocortisone related to Inflammation' supported by the sentence: 'Higher basal cortisol predicts verbal memory loss in postmenopausal women: Rancho Bernardo Study.'?,"Yes, the statement is indirectly supported by the sentence provided. Hydrocortisone is a type of corticosteroid, which is released in response to stress, including inflammation, and it has been linked to memory loss in postmenopausal women in this study. Therefore, it can be inferred that hydrocortisone, being a stress hormone, could be indirectly linked to inflammation, as stress can induce inflammatory responses in the body, and both can contribute to verbal memory loss in postmenopausal women." -24030854,Hydrocortisone related to Hypoxemia,387,"A growing body of evidence now suggests that endogenous cortisol, which is produced in significant quantities by the body in a diurnal rhythm, is an important regulator of allergic disease expression and allergic inflammatory responses: lung function varies along with plasma cortisol levels; the number of circulating inflammatory cells varies with plasma cortisol levels; and low levels of endogenous cortisol may be associated with risk for asthma.",True,"Is the triple 'Hydrocortisone related to Hypoxemia' supported by the sentence: 'A growing body of evidence now suggests that endogenous cortisol, which is produced in significant quantities by the body in a diurnal rhythm, is an important regulator of allergic disease expression and allergic inflammatory responses: lung function varies along with plasma cortisol levels; the number of circulating inflammatory cells varies with plasma cortisol levels; and low levels of endogenous cortisol may be associated with risk for asthma.'?","Yes, there is indirect support for the relationship between hydrocortisone (a synthetic form of cortisol) and hypoxemia (a condition characterized by low oxygen levels in the blood) in this sentence. This is because cortisol, which hydrocortisone mimics, is known to regulate allergic disease expression and inflammatory responses, including lung function and the number of circulating inflammatory cells, all of which can impact oxygen levels in the blood. Therefore, conditions associated with low levels of endogenous cortisol, such as asthma, could potentially be associated with hypoxemia. However, this is an indirect relationship and further research would be needed to directly link hydrocortisone to hypoxemia." -12533519,Hydrocortisone related to Insulin resistance,388,"In conclusion, the data presented here suggest that cortisol can contribute to insulin resistance in ponies with hyperlipoproteinaemia.",True,"Is the triple 'Hydrocortisone related to Insulin resistance' supported by the sentence: 'In conclusion, the data presented here suggest that cortisol can contribute to insulin resistance in ponies with hyperlipoproteinaemia.'?","Yes, the statement does provide indirect support for a relationship between hydrocortisone (a form of cortisol) and insulin resistance. The sentence suggests that cortisol can contribute to insulin resistance in ponies with hyperlipoproteinaemia. Hydrocortisone, being a type of cortisol, could therefore also potentially contribute to insulin resistance, although it is not directly mentioned in this sentence." -27747116,Hydrocortisone causes toxic shock syndrome,389,"OBJECTIVE: To investigate the relationship of cortisol concentrations during the first week of life to patent ductus arteriosus (PDA), markers of lung inflammation, and respiratory outcome in very low birth weight infants.",False,"Is the triple 'Hydrocortisone causes toxic shock syndrome' supported by the sentence: 'OBJECTIVE: To investigate the relationship of cortisol concentrations during the first week of life to patent ductus arteriosus (PDA), markers of lung inflammation, and respiratory outcome in very low birth weight infants.'?","No, this statement does not support the claim that hydrocortisone causes toxic shock syndrome. The objective in this sentence is to investigate the relationship between cortisol concentrations during the first week of life, patent ductus arteriosus (PDA), markers of lung inflammation, and respiratory outcome in very low birth weight infants. Hydrocortisone is not mentioned in this sentence, nor is there any mention of toxic shock syndrome." -27747115,Hydrocortisone causes Sepsis,390,Oral pH-modified release budesonide versus 6-methylprednisolone in active Crohn's disease.,False,Is the triple 'Hydrocortisone causes Sepsis' supported by the sentence: 'Oral pH-modified release budesonide versus 6-methylprednisolone in active Crohn's disease.'?,"No, this sentence does not provide any indirect support for the statement that hydrocortisone causes sepsis. The sentence discusses oral pH-modified release budesonide versus 6-methylprednisolone in active Crohn's disease, which is unrelated to hydrocortisone causing sepsis." -27073884,Hydrocortisone causes atopic eczema,391,Pharmacokinetics of high dose methylprednisolone and use in hematological malignancies.,False,Is the triple 'Hydrocortisone causes atopic eczema' supported by the sentence: 'Pharmacokinetics of high dose methylprednisolone and use in hematological malignancies.'?,"No, this statement does not indirectly support the claim that hydrocortisone causes atopic eczema. The sentence discusses the pharmacokinetics (the process of drug absorption, distribution, metabolism, and excretion) of high-dose methylprednisolone, which is a corticosteroid used in treating hematological malignancies (blood cancers). Hydrocortisone is also a corticosteroid, but this information does not establish a connection between hydrocortisone use and atopic eczema, which is an inflammatory skin condition." -25383174,Hydrocortisone causes fibromyalgia,392,"Methylprednisolone in advanced chronic lymphocytic leukaemia: rationale for, and effectiveness of treatment suggested by DiSC assay.",False,"Is the triple 'Hydrocortisone causes fibromyalgia' supported by the sentence: 'Methylprednisolone in advanced chronic lymphocytic leukaemia: rationale for, and effectiveness of treatment suggested by DiSC assay.'?","No, this statement does not provide any indirect support for the idea that Hydrocortisone causes fibromyalgia. The sentence discusses Methylprednisolone, which is a different corticosteroid than Hydrocortisone, and its use in treating advanced chronic lymphocytic leukaemia, not fibromyalgia." -25205462,Hydrocortisone causes hypotensive disorder,393,The effects of intravenous pulse methylprednisolone on immunological and inflammatory processes in ankylosing spondylitis.,False,Is the triple 'Hydrocortisone causes hypotensive disorder' supported by the sentence: 'The effects of intravenous pulse methylprednisolone on immunological and inflammatory processes in ankylosing spondylitis.'?,"No, this statement does not indirectly support the claim that hydrocortisone causes hypotensive disorder. The sentence discusses the effects of intravenous pulse methylprednisolone on immunological and inflammatory processes in ankylosing spondylitis, but it does not mention hydrocortisone or hypotension. Hypotension is not listed as a side effect, nor is there any indirect mention of it through other symptoms or conditions. Therefore, this statement does not provide any evidence to support the claim." -20591759,Hydrocortisone causes Hypoxemia,394,The effect of methylprednisolone (MP) on the cell kinetic response to cyclophosphamide (CP) and Adriamycin (ADR) in C3H/HeJ spontaneous mammary tumors and hematopoietic tissue was investigated.,False,Is the triple 'Hydrocortisone causes Hypoxemia' supported by the sentence: 'The effect of methylprednisolone (MP) on the cell kinetic response to cyclophosphamide (CP) and Adriamycin (ADR) in C3H/HeJ spontaneous mammary tumors and hematopoietic tissue was investigated.'?,"No, this sentence does not provide any indirect support for the claim that hydrocortisone causes hypoxemia. The sentence discusses an investigation into the effect of methylprednisolone on the cell kinetic response to cyclophosphamide and Adriamycin in spontaneous mammary tumors and hematopoietic tissue in C3H/HeJ mice. There is no mention or implication of hydrocortisone, hypoxemia, or any related concepts in this sentence." -18446972,Hydrocortisone causes congenital adrenal hyperplasia,395,High-dose intravenous methyl-prednisolone in chronic polymyositis/dermatomyositis.,False,Is the triple 'Hydrocortisone causes congenital adrenal hyperplasia' supported by the sentence: 'High-dose intravenous methyl-prednisolone in chronic polymyositis/dermatomyositis.'?,"No, this sentence does not support the claim that hydrocortisone causes congenital adrenal hyperplasia. The sentence discusses the use of high-dose intravenous methyl-prednisolone in chronic polymyositis/dermatomyositis, which is a different medication (methyl-prednisolone) and different condition (polymyositis/dermatomyositis) from hydrocortisone and congenital adrenal hyperplasia, respectively." -18240145,Hydrocortisone causes injury,396,Comparing Intratympanic Gentamicin with Methylprednisolone in Meniere's Disease with Non-Serviceable Hearing.,False,Is the triple 'Hydrocortisone causes injury' supported by the sentence: 'Comparing Intratympanic Gentamicin with Methylprednisolone in Meniere's Disease with Non-Serviceable Hearing.'?,"No, this statement does not indirectly support the idea that hydrocortisone causes injury, as it compares two different treatments for Meniere's disease, one being methylprednisolone, not hydrocortisone, in relation to their impact on hearing." -17359303,Hydrocortisone causes influenza,397,"High-dose methylprednisolone, vincristine, MTX, and ara-C (SOMA) as initial bulk reducing therapy in non-Hodgkin's lymphoma of unfavorable histology: preliminary results of an ongoing phase II study.",False,"Is the triple 'Hydrocortisone causes influenza' supported by the sentence: 'High-dose methylprednisolone, vincristine, MTX, and ara-C (SOMA) as initial bulk reducing therapy in non-Hodgkin's lymphoma of unfavorable histology: preliminary results of an ongoing phase II study.'?","No, this statement does not provide any indirect support for the claim that hydrocortisone causes influenza. The sentence discusses a phase II study on the use of high-dose methylprednisolone, vincristine, MTX, and ara-C in treating non-Hodgkin's lymphoma, but it does not mention hydrocortisone or influenza." -13585273,"Hydrocortisone causes dermatitis, atopic",398,A Prospective Study Comparing the Efficacy of Local Injection of Platelet-Rich Plasma (PRP) vs Methylprednisolone in Plantar Fasciitis.,False,"Is the triple 'Hydrocortisone causes dermatitis, atopic' supported by the sentence: 'A Prospective Study Comparing the Efficacy of Local Injection of Platelet-Rich Plasma (PRP) vs Methylprednisolone in Plantar Fasciitis.'?","No, this statement does not provide indirect evidence for the claim that hydrocortisone causes atopic dermatitis. The study compares the efficacy of local injection of platelet-rich plasma (PRP) versus methylprednisolone in plantar fasciitis, which does not involve hydrocortisone or discuss its potential side effects on skin conditions like atopic dermatitis." -12645476,Hydrocortisone causes obesity disorder,399,A controlled trial of 6-methylprednisolone in acute alcoholic hepatitis.,False,Is the triple 'Hydrocortisone causes obesity disorder' supported by the sentence: 'A controlled trial of 6-methylprednisolone in acute alcoholic hepatitis.'?,"No, this sentence does not provide any support for the idea that hydrocortisone causes obesity disorder. The sentence is about a controlled trial of 6-methylprednisolone in acute alcoholic hepatitis, not hydrocortisone, and it does not mention anything about obesity disorder." -10068843,Hydrocortisone causes Inflammation,400,[Short-term therapy with methylprednisolone in exacerbated obstructive respiratory tract diseases].,False,Is the triple 'Hydrocortisone causes Inflammation' supported by the sentence: '[Short-term therapy with methylprednisolone in exacerbated obstructive respiratory tract diseases].'?,"No, this statement does not support the claim that Hydrocortisone causes inflammation. Methylprednisolone is a synthetic glucocorticoid, not Hydrocortisone, and it is used in short-term therapy for exacerbated obstructive respiratory tract diseases, which implies it is used to reduce inflammation, not cause it." -9850315,Hydrocortisone causes dissociative amnesia,401,Methylprednisolone and 60 Days in Hospital Survival in Coronavirus Disease 2019 Pneumonia.,False,Is the triple 'Hydrocortisone causes dissociative amnesia' supported by the sentence: 'Methylprednisolone and 60 Days in Hospital Survival in Coronavirus Disease 2019 Pneumonia.'?,"No, this statement is not supported by the provided sentence. The sentence discusses Methylprednisolone, another type of corticosteroid, in relation to survival rates in COVID-19 patients, not Hydrocortisone or its effects on memory function." -9318796,Hydrocortisone causes adrenocortical insufficiency,402,Intra-Carpal Injection of Ozone versus Methylprednisolone in Carpal Tunnel Syndrome of Systemic Sclerosis Patients: A Randomized Single-Blind Clinical Trial.,False,Is the triple 'Hydrocortisone causes adrenocortical insufficiency' supported by the sentence: 'Intra-Carpal Injection of Ozone versus Methylprednisolone in Carpal Tunnel Syndrome of Systemic Sclerosis Patients: A Randomized Single-Blind Clinical Trial.'?,"No, this statement is not indirectly supported by this sentence. The sentence describes a clinical trial comparing ozone injections to methylprednisolone injections in carpal tunnel syndrome patients with systemic sclerosis, but it does not mention hydrocortisone or adrenocortical insufficiency. Hydrocortisone is a type of corticosteroid, similar to methylprednisolone, but without specific mention, no connection can be inferred." -9145908,Hydrocortisone causes otitis externa,403,Methylprednisolone Pulses in West Syndrome: A New Weapon in the Armory-Is it Needed?,False,Is the triple 'Hydrocortisone causes otitis externa' supported by the sentence: 'Methylprednisolone Pulses in West Syndrome: A New Weapon in the Armory-Is it Needed?'?,"No, this statement is not indirectly supported by the given sentence. The sentence discusses Methylprednisolone Pulses in West Syndrome, which is unrelated to Hydrocortisone and Otitis Externa." -8699464,Hydrocortisone causes adrenal cortex neoplasm,404,Patient underwent treatment with milrinone and methylprednisolone that showed reduction in myocardial inflammation and significantly improved myocardial contractility.,False,Is the triple 'Hydrocortisone causes adrenal cortex neoplasm' supported by the sentence: 'Patient underwent treatment with milrinone and methylprednisolone that showed reduction in myocardial inflammation and significantly improved myocardial contractility.'?,"No, this sentence does not provide any indirect support for the statement that hydrocortisone causes adrenal cortex neoplasm. The sentence mentions methylprednisolone, which is a synthetic glucocorticoid like hydrocortisone, but it only mentions its use in treating myocardial inflammation, not its potential to cause neoplasms in the adrenal cortex." -8657746,Hydrocortisone causes neoplasm,405,"Neurologically, the therapeutic dosages of anticoagulants are linked to the high incidence of thrombotic complexities, while methylprednisolone is associated with myopathy.",False,"Is the triple 'Hydrocortisone causes neoplasm' supported by the sentence: 'Neurologically, the therapeutic dosages of anticoagulants are linked to the high incidence of thrombotic complexities, while methylprednisolone is associated with myopathy.'?","No, this sentence does not provide any indirect support for the statement that hydrocortisone causes neoplasm (neoplasms are abnormal growths that can become cancerous). The sentence discusses neurological side effects associated with anticoagulants and methylprednisolone, but it does not mention hydrocortisone or any related side effects. Therefore, it does not provide any relevant information to support the initial statement." -7929803,Hydrocortisone causes Insulin resistance,406,"Conclusion: Based on the current data, the efficacy and safety of local injection of triamcinolone and methylprednisolone at doses of 20 and 40 mg were associated with a significant improvement in pain, functional status, and strength.",False,"Is the triple 'Hydrocortisone causes Insulin resistance' supported by the sentence: 'Conclusion: Based on the current data, the efficacy and safety of local injection of triamcinolone and methylprednisolone at doses of 20 and 40 mg were associated with a significant improvement in pain, functional status, and strength.'?","No, this sentence does not provide any support for the claim that hydrocortisone causes insulin resistance, directly or indirectly. The sentence discusses the efficacy and safety of local injections of triamcinolone and methylprednisolone, which are different types of corticosteroids, on pain, functional status, and strength. It does not mention hydrocortisone, insulin, or insulin resistance. Therefore, it cannot be used as evidence to support or refute the claim about hydrocortisone causing insulin resistance." -7432490,Hydrocortisone causes pancreatitis,407,OBJECTIVE: To validate the responsiveness of cerebrospinal fluid (CSF) inflammatory biomarkers to treatment with natalizumab and methylprednisolone in progressive MS and to examine the relationship between CSF inflammatory and tissue damage biomarkers.,False,Is the triple 'Hydrocortisone causes pancreatitis' supported by the sentence: 'OBJECTIVE: To validate the responsiveness of cerebrospinal fluid (CSF) inflammatory biomarkers to treatment with natalizumab and methylprednisolone in progressive MS and to examine the relationship between CSF inflammatory and tissue damage biomarkers.'?,"No, this sentence does not indirectly support the statement that hydrocortisone causes pancreatitis. The sentence discusses a study on cerebrospinal fluid (CSF) inflammatory biomarkers in progressive multiple sclerosis (MS) treated with natalizumab and methylprednisolone, but it does not mention hydrocortisone or pancreatitis." -26997315,Hydrocortisone affects congenital adrenal hyperplasia,408,The region was identified as a significant predictor of use of intravenous methylprednisolone in MCD and MN patients.,False,Is the triple 'Hydrocortisone affects congenital adrenal hyperplasia' supported by the sentence: 'The region was identified as a significant predictor of use of intravenous methylprednisolone in MCD and MN patients.'?,"No, this sentence does not provide indirect support for the statement that hydrocortisone affects congenital adrenal hyperplasia (CAH). The sentence discusses the use of intravenous methylprednisolone in MCD (Minimal Change Disease) and MN (Membranous Nephropathy) patients, which is not directly related to hydrocortisone use in CAH. Hydrocortisone is a common treatment for CAH, but this sentence does not provide any information about this relationship, nor does it mention CAH at all." -26940919,Hydrocortisone affects cardiac arrest,409,"Clinical commentary on ""Two cases of anaphylactic shock by methylprednisolone in neuromyelitis optica"".",False,"Is the triple 'Hydrocortisone affects cardiac arrest' supported by the sentence: 'Clinical commentary on ""Two cases of anaphylactic shock by methylprednisolone in neuromyelitis optica"".'?","No, this statement is not supported by the provided sentence. Hydrocortisone is a type of corticosteroid, while methylprednisolone is another type of corticosteroid drug. The sentence provided discusses two cases of anaphylactic shock caused by methylprednisolone, not hydrocortisone, in patients with neuromyelitis optica. It does not provide any information about hydrocortisone affecting cardiac arrest, directly or indirectly." -26840479,Hydrocortisone affects myocardial infarction,410,CONCLUSION: Results show that inhalation of budesonide (2 mg 3 times/day) and systemic methylprednisolone (40 mg/day) had similar clinical outcome in AECOPD.,False,Is the triple 'Hydrocortisone affects myocardial infarction' supported by the sentence: 'CONCLUSION: Results show that inhalation of budesonide (2 mg 3 times/day) and systemic methylprednisolone (40 mg/day) had similar clinical outcome in AECOPD.'?,"No, this sentence does not provide evidence to support the claim that hydrocortisone affects myocardial infarction, either directly or indirectly. The sentence discusses the clinical outcomes of budesonide and methylprednisolone in acute exacerbations of chronic obstructive pulmonary disease (AECOPD), but it does not mention hydrocortisone or myocardial infarction. Hydrocortisone, budesonide, and methylprednisolone are all corticosteroids, but they have different pharmacokinetic properties, which means they may have different effects on various physiological processes, including myocardial infarction risk. Therefore, further investigation is needed to establish any potential link between hydrocortisone use and myocardial infarction risk." -24701128,Hydrocortisone affects Sepsis,411,A Clinical Trial Comparing the Safety and Efficacy of Topical Tacrolimus versus Methylprednisolone in Ocular Graft-versus-Host Disease.,False,Is the triple 'Hydrocortisone affects Sepsis' supported by the sentence: 'A Clinical Trial Comparing the Safety and Efficacy of Topical Tacrolimus versus Methylprednisolone in Ocular Graft-versus-Host Disease.'?,"No, this sentence does not provide any direct or indirect support for the statement that Hydrocortisone affects Sepsis. The sentence discusses a clinical trial comparing Topical Tacrolimus versus Methylprednisolone in Ocular Graft-versus-Host Disease, but it does not mention Hydrocortisone or Sepsis." -21274202,Hydrocortisone affects osteoarthritis,412,The purpose of this study was to evaluate the efficacy of supraperiosteal injection of methylprednisolone compared with an oral tablet form and intravenous (i.v.) injection in the prevention of postoperative pain and oedema associated with inflammation.,False,Is the triple 'Hydrocortisone affects osteoarthritis' supported by the sentence: 'The purpose of this study was to evaluate the efficacy of supraperiosteal injection of methylprednisolone compared with an oral tablet form and intravenous (i.v.) injection in the prevention of postoperative pain and oedema associated with inflammation.'?,"No, this sentence does not support the claim that hydrocortisone affects osteoarthritis, directly or indirectly. The sentence discusses a study on postoperative pain management using methylprednisolone, not hydrocortisone, in various forms (supraperiosteal injection, oral tablet, intravenous injection). Hydrocortisone is another type of corticosteroid, like methylprednisolone, but it is not mentioned in this sentence, so there is no indirect support for its effect on osteoarthritis." -20701310,Hydrocortisone affects psoriasis,413,Gamma globulin and methylprednisolone in idiopathic thrombocytopenic purpura.,False,Is the triple 'Hydrocortisone affects psoriasis' supported by the sentence: 'Gamma globulin and methylprednisolone in idiopathic thrombocytopenic purpura.'?,"No, this sentence does not provide support for the statement that hydrocortisone affects psoriasis, directly or indirectly. The sentence mentions gamma globulin and methylprednisolone, not hydrocortisone, and it discusses their use in idiopathic thrombocytopenic purpura, not psoriasis." -20336537,Hydrocortisone affects dermatitis,414,Methylprednisolone and hepatotoxicity in Graves' ophthalmopathy.,False,Is the triple 'Hydrocortisone affects dermatitis' supported by the sentence: 'Methylprednisolone and hepatotoxicity in Graves' ophthalmopathy.'?,"No, this sentence does not provide support for the statement that hydrocortisone affects dermatitis, directly or indirectly. The sentence discusses Methylprednisolone, another type of corticosteroid, and its potential hepatotoxicity in Graves' ophthalmopathy, which is an eye condition associated with Graves' disease, an autoimmune disorder. It does not mention hydrocortisone, its effects on skin conditions like dermatitis, nor any indirect link between these two corticosteroids in this context." -20137862,Hydrocortisone affects fibromyalgia,415,"In orthognathic surgery, methylprednisolone > or =85 mg administered intravenously seemed sufficient to produce a significant decrease in edema, and several trials pointed toward a neuroregeneration effect, but no statistical analysis could be performed.",False,"Is the triple 'Hydrocortisone affects fibromyalgia' supported by the sentence: 'In orthognathic surgery, methylprednisolone > or =85 mg administered intravenously seemed sufficient to produce a significant decrease in edema, and several trials pointed toward a neuroregeneration effect, but no statistical analysis could be performed.'?","No, this sentence does not provide indirect support for the statement that hydrocortisone affects fibromyalgia. The sentence discusses the effects of methylprednisolone in orthognathic surgery, not hydrocortisone, nor does it mention anything about fibromyalgia. Hydrocortisone, methylprednisolone, and other corticosteroids do share similar mechanisms of action, but this alone does not provide sufficient evidence to make a connection between methylprednisolone used in orthognathic surgery and hydrocortisone’s potential effects on fibromyalgia." -19555227,Hydrocortisone affects pneumonia,416,Response of symptoms and synovitis to intra-muscular methylprednisolone in osteoarthritis of the hand: an ultrasonographic study.,False,Is the triple 'Hydrocortisone affects pneumonia' supported by the sentence: 'Response of symptoms and synovitis to intra-muscular methylprednisolone in osteoarthritis of the hand: an ultrasonographic study.'?,"No, this statement is not supported by the sentence provided. The sentence discusses the response to intra-muscular methylprednisolone in osteoarthritis of the hand, not hydrocortisone, and it does not mention anything about pneumonia. Hydrocortisone and methylprednisolone are both corticosteroids, but they are not identical, and the effects of one cannot be directly inferred from the effects of the other. Furthermore, the context is different as it discusses osteoarthritis, not pneumonia." -19531871,Hydrocortisone affects atrial fibrillation,417,Long-term results of high-dose methylprednisolone in aplastic anemia.,False,Is the triple 'Hydrocortisone affects atrial fibrillation' supported by the sentence: 'Long-term results of high-dose methylprednisolone in aplastic anemia.'?,"No, this sentence does not provide support for the statement that hydrocortisone affects atrial fibrillation, directly or indirectly. Methylprednisolone is a different type of steroid than hydrocortisone, and while both can have effects on various body systems, this sentence is specifically discussing its use in aplastic anemia, not atrial fibrillation." -18495054,Hydrocortisone affects lymphoma,418,"Efficacy of methylprednisolone, cyclophosphamide in pediatric IgA nephropathy assessed by renal biopsy.",False,"Is the triple 'Hydrocortisone affects lymphoma' supported by the sentence: 'Efficacy of methylprednisolone, cyclophosphamide in pediatric IgA nephropathy assessed by renal biopsy.'?","No, this sentence does not provide indirect support for the idea that hydrocortisone affects lymphoma. The sentence discusses the efficacy of methylprednisolone, not hydrocortisone, in pediatric IgA nephropathy, which is a kidney disease, not lymphoma. Therefore, there is no connection made between these two concepts in this sentence." -18495053,Hydrocortisone affects leukemia,419,"The impaired effect on lymphocyte blastogenesis of glucocorticoids administered in vivo, in contrast to a normal in vitro reaction to dexamethasone, together with recent findings of an altered glucocorticoid receptor pharmacology in AD, points to a decreased biological in vivo efficiency of methylprednisolone in atopic dermatitis.",True,"Is the triple 'Hydrocortisone affects leukemia' supported by the sentence: 'The impaired effect on lymphocyte blastogenesis of glucocorticoids administered in vivo, in contrast to a normal in vitro reaction to dexamethasone, together with recent findings of an altered glucocorticoid receptor pharmacology in AD, points to a decreased biological in vivo efficiency of methylprednisolone in atopic dermatitis.'?","Yes, this sentence does provide indirect support for the idea that hydrocortisone, which is a type of glucocorticoid, could affect leukemia. The sentence discusses how glucocorticoids, such as methylprednisolone, have an impaired effect on lymphocyte blastogenesis in vivo, but not in vitro, in atopic dermatitis (AD). This could suggest an altered glucocorticoid receptor pharmacology in AD, which could potentially impact the effectiveness of these drugs in treating conditions like leukemia, which involves abnormal lymphocyte proliferation. However, this is a very indirect link, as it does not directly mention hydrocortisone or leukemia, but rather discusses glucocorticoids in general and their effect on lymphocytes in AD." -18310128,Hydrocortisone affects toxic shock syndrome,420,"CONCLUSION: In this single-center trial, combined vasopressin-epinephrine and methylprednisolone during resuscitation and stress-dose hydrocortisone in postresuscitation shock improved survival in refractory in-hospital cardiac arrest.",False,"Is the triple 'Hydrocortisone affects toxic shock syndrome' supported by the sentence: 'CONCLUSION: In this single-center trial, combined vasopressin-epinephrine and methylprednisolone during resuscitation and stress-dose hydrocortisone in postresuscitation shock improved survival in refractory in-hospital cardiac arrest.'?","No, this sentence does not indirectly support the statement that hydrocortisone affects toxic shock syndrome. The sentence discusses the effects of combined vasopressin-epinephrine, methylprednisolone, and hydrocortisone on survival rates in in-hospital cardiac arrest patients, but it does not mention anything about toxic shock syndrome." -17910566,Hydrocortisone affects atopic eczema,421,Weekly bortezomib/methylprednisolone is effective and well tolerated in relapsed multiple myeloma.,False,Is the triple 'Hydrocortisone affects atopic eczema' supported by the sentence: 'Weekly bortezomib/methylprednisolone is effective and well tolerated in relapsed multiple myeloma.'?,"No, this sentence does not provide indirect support for the statement that hydrocortisone affects atopic eczema. The sentence discusses the effectiveness and tolerability of bortezomib/methylprednisolone in relapsed multiple myeloma, which does not relate to hydrocortisone or atopic eczema. Hydrocortisone is a type of corticosteroid often used to treat skin conditions like eczema, but this sentence does not provide any information about its effects on atopic eczema." -15925719,Hydrocortisone affects Inflammation,422,Amsacrine combined with etoposide and high-dose methylprednisolone as salvage therapy in acute lymphoblastic leukemia in children.,False,Is the triple 'Hydrocortisone affects Inflammation' supported by the sentence: 'Amsacrine combined with etoposide and high-dose methylprednisolone as salvage therapy in acute lymphoblastic leukemia in children.'?,"No, this sentence does not provide direct evidence for the statement ""Hydrocortisone affects inflammation"". The sentence mentions high-dose methylprednisolone, which is a corticosteroid like hydrocortisone, but it does not specify the effects on inflammation. Furthermore, it discusses its use in acute lymphoblastic leukemia in children, which is not directly related to inflammation." -14970164,Hydrocortisone affects Insulin resistance,423,Controlled clinical trial of IV cyclophosphamide versus IV methylprednisolone in severe neurological manifestations in systemic lupus erythematosus.,False,Is the triple 'Hydrocortisone affects Insulin resistance' supported by the sentence: 'Controlled clinical trial of IV cyclophosphamide versus IV methylprednisolone in severe neurological manifestations in systemic lupus erythematosus.'?,"No, this sentence does not provide support for the statement that hydrocortisone affects insulin resistance, directly or indirectly. The sentence describes a controlled clinical trial comparing IV cyclophosphamide to IV methylprednisolone in severe neurological manifestations in systemic lupus erythematosus (SLE). While methylprednisolone is a type of corticosteroid like hydrocortisone, there is no mention of insulin resistance, hydrocortisone, or any related mechanisms in this sentence." -14804311,Hydrocortisone affects injury,424,Delayed hypersensitivity to 6-methyl-prednisolone in Henoch Schoenlein syndrome.,False,Is the triple 'Hydrocortisone affects injury' supported by the sentence: 'Delayed hypersensitivity to 6-methyl-prednisolone in Henoch Schoenlein syndrome.'?,"No, this statement does not provide direct support for the triple ""Hydrocortisone affects injury"". Hydrocortisone and 6-methyl-prednisolone are both glucocorticoids, but they are not identical, and the sentence does not mention any relationship between them in the context of injury response." -14533429,Hydrocortisone affects hypotensive disorder,425,Rectal absorption of radioactive 6-alpha-methyl prednisolone in ulcerative colitis.,False,Is the triple 'Hydrocortisone affects hypotensive disorder' supported by the sentence: 'Rectal absorption of radioactive 6-alpha-methyl prednisolone in ulcerative colitis.'?,"No, this sentence does not provide support for the statement that hydrocortisone affects hypotensive disorder, directly or indirectly. The sentence discusses rectal absorption of radioactive 6-alpha-methyl prednisolone in ulcerative colitis, which is not directly related to hydrocortisone or hypotension." -13999195,Hydrocortisone affects congenital adrenal hyperplasia,426,Controlled trial of pulse methylprednisolone versus two regimens of pulse cyclophosphamide in severe lupus nephritis.,False,Is the triple 'Hydrocortisone affects congenital adrenal hyperplasia' supported by the sentence: 'Controlled trial of pulse methylprednisolone versus two regimens of pulse cyclophosphamide in severe lupus nephritis.'?,"No, this sentence does not provide support for the statement that hydrocortisone affects congenital adrenal hyperplasia (CAH). The sentence discusses a controlled trial involving pulse methylprednisolone and pulse cyclophosphamide in severe lupus nephritis, which is an autoimmune disease, not CAH, which is a genetic disorder affecting the adrenal glands due to enzyme deficiencies, such as 21-hydroxylase deficiency, leading to excess production of androgens in utero, which can cause virilization in female fetuses, among other symptoms. Hydrocortisone, a type of corticosteroid, is sometimes used in treatment for CAH, but it is not directly mentioned in this sentence, nor is there any clear connection made to CAH in this context." -13347553,Hydrocortisone affects asthma,427,"The National Heart, Lung, and Blood Institute's ARDS Network currently is testing the use of methylprednisolone in late ARDS.",False,"Is the triple 'Hydrocortisone affects asthma' supported by the sentence: 'The National Heart, Lung, and Blood Institute's ARDS Network currently is testing the use of methylprednisolone in late ARDS.'?","No, this sentence does not provide indirect support for the idea that hydrocortisone affects asthma. The sentence discusses the National Heart, Lung, and Blood Institute’s ARDS Network testing the use of methylprednisolone in late ARDS (Acute Respiratory Distress Syndrome). Methylprednisolone is a type of corticosteroid, similar to hydrocortisone, but it is not the same compound, nor does it imply any connection to asthma in this context." -13180935,Hydrocortisone affects hypotensive disorder,428,"(3) Preliminary results of an interim analysis from an ongoing randomized, prospective study showed that methylprednisolone (plus an antiviral agent?) may be useful for improving peripheral vestibular function in vestibular neuritis.",False,"Is the triple 'Hydrocortisone affects hypotensive disorder' supported by the sentence: '(3) Preliminary results of an interim analysis from an ongoing randomized, prospective study showed that methylprednisolone (plus an antiviral agent?) may be useful for improving peripheral vestibular function in vestibular neuritis.'?","No, this sentence does not provide support for the triple statement “Hydrocortisone affects hypotensive disorder”. The sentence mentions methylprednisolone, which is a different glucocorticoid than hydrocortisone, and it discusses its potential use in improving peripheral vestibular function in vestibular neuritis, not in treating hypotensive disorders." -11695335,Hydrocortisone affects Hypoxemia,429,This is the first report of cyclophosphamide and methylprednisolone leading to complete and sustained resolution of GAVE in association with systemic sclerosis.,False,Is the triple 'Hydrocortisone affects Hypoxemia' supported by the sentence: 'This is the first report of cyclophosphamide and methylprednisolone leading to complete and sustained resolution of GAVE in association with systemic sclerosis.'?,"No, this sentence does not provide support for the statement that hydrocortisone affects hypoxemia, directly or indirectly. The sentence discusses the effects of cyclophosphamide and methylprednisolone on gastrointestinal angiodysplasia associated with systemic sclerosis (GAVE). There is no mention of hydrocortisone, hypoxemia, or any related conditions in this sentence. Therefore, it does not provide any basis for inferring a relationship between these entities." -11304252,Hydrocortisone affects obesity disorder,430,We compared lymphocyte-suppressive potencies of prednisolone and methylprednisolone in rheumatoid arthritis (RA).,False,Is the triple 'Hydrocortisone affects obesity disorder' supported by the sentence: 'We compared lymphocyte-suppressive potencies of prednisolone and methylprednisolone in rheumatoid arthritis (RA).'?,"No, this statement does not provide any evidence to support the claim that hydrocortisone affects obesity disorder, directly or indirectly. The sentence discusses a comparison of lymphocyte-suppressive potencies of prednisolone and methylprednisolone in rheumatoid arthritis (RA), but it does not mention hydrocortisone or any disorders related to obesity." -10523644,Hydrocortisone affects injury,431,"Despite the lucrative ""off label"" markets for methylprednisolone in SCI, no Food and Drug Association indication has been obtained.",False,"Is the triple 'Hydrocortisone affects injury' supported by the sentence: 'Despite the lucrative ""off label"" markets for methylprednisolone in SCI, no Food and Drug Association indication has been obtained.'?","No, this sentence does not indirectly support the statement that hydrocortisone affects injury, particularly in spinal cord injuries (SCI). The sentence discusses methylprednisolone, not hydrocortisone, and its use in SCI, but it does not provide any information on how hydrocortisone might affect injury." -10431364,Hydrocortisone affects Inflammation,432,Extraocular muscle responses to high dose intravenous methylprednisolone in myasthenia gravis.,False,Is the triple 'Hydrocortisone affects Inflammation' supported by the sentence: 'Extraocular muscle responses to high dose intravenous methylprednisolone in myasthenia gravis.'?,"No, this sentence does not provide direct or indirect support for the statement that Hydrocortisone affects Inflammation. The sentence discusses extraocular muscle responses to high dose intravenous methylprednisolone in myasthenia gravis, but it does not mention Hydrocortisone or Inflammation. Hydrocortisone is a type of corticosteroid often used to reduce inflammation, but the sentence provided does not contain any information linking these concepts together." -10074536,Hydrocortisone affects HIV infectious disease,433,The increased CSF levels of TNF-sRp55 in response to MP circumstantially suggest that this receptor could partially account for the beneficial effects of MP in acute MS.,False,Is the triple 'Hydrocortisone affects HIV infectious disease' supported by the sentence: 'The increased CSF levels of TNF-sRp55 in response to MP circumstantially suggest that this receptor could partially account for the beneficial effects of MP in acute MS.'?,"No, this statement does not provide support for the triple statement about Hydrocortisone, HIV, and infectious disease. The sentence discusses the effects of MP (Methylprednisolone) on acute MS (Multiple Sclerosis) in relation to TNF-sRp55 in CSF (Cerebrospinal Fluid). While both Hydrocortisone and MP are glucocorticoids used in treating inflammatory diseases, there is no direct mention or implication about Hydrocortisone, HIV, or their relationship to an infectious disease in this sentence." -9872405,Hydrocortisone affects toxic shock syndrome,434,"Such an effect has been demonstrated between clarithromycin and methylprednisolone, two drugs that may be administered concomitantly in asthma.",False,"Is the triple 'Hydrocortisone affects toxic shock syndrome' supported by the sentence: 'Such an effect has been demonstrated between clarithromycin and methylprednisolone, two drugs that may be administered concomitantly in asthma.'?","No, this sentence does not provide indirect support for the statement that hydrocortisone affects toxic shock syndrome. The sentence discusses an effect between clarithromycin and methylprednisolone, two drugs used together in asthma treatment. Hydrocortisone is not mentioned, nor is there any connection made to toxic shock syndrome." -9610203,Hydrocortisone affects neoplasm,435,"In this study, low-dose methylprednisolone (0.8 mg/kg/day, MP) was used to induce a steroid-resistant lupus nephritis (SR-LN) mouse model in weeks one to four, and a therapeutic steroid dosage (MP 12 mg/kg/day) or a combined PNS (PNS 100 mg/kg/day) treatment was administered from week five to eight.",False,"Is the triple 'Hydrocortisone affects neoplasm' supported by the sentence: 'In this study, low-dose methylprednisolone (0.8 mg/kg/day, MP) was used to induce a steroid-resistant lupus nephritis (SR-LN) mouse model in weeks one to four, and a therapeutic steroid dosage (MP 12 mg/kg/day) or a combined PNS (PNS 100 mg/kg/day) treatment was administered from week five to eight.'?","No, this sentence does not provide direct evidence to support the claim that hydrocortisone affects neoplasm (a type of tumor). The sentence discusses a study where low-dose methylprednisolone was used to induce a steroid-resistant lupus nephritis (SR-LN) mouse model, and then either a therapeutic steroid dosage (methylprednisolone) or a combined PNS treatment was administered from week five to eight. Hydrocortisone is not mentioned in this sentence, nor is there any reference to neoplasms (tumors). Therefore, this sentence does not provide any indirect evidence either, as there is no connection to hydrocortisone or neoplasms in this context." -9120606,Hydrocortisone affects asthma,436,MP was administrated in three alternative ways: intraperitoneally during the induction of cytotoxic edema or immediately after finishing cytotoxic edema induction in a dose of 100 mg/kg b.w.; into the internal carotid artery within 2 h after finishing cytotoxic edema induction in a dose of 50 mg/kg b.w.; into internal carotid artery 10 min after edema induction by BBBd in a dose of 50 mg/kg b.w.,False,Is the triple 'Hydrocortisone affects asthma' supported by the sentence: 'MP was administrated in three alternative ways: intraperitoneally during the induction of cytotoxic edema or immediately after finishing cytotoxic edema induction in a dose of 100 mg/kg b.w.; into the internal carotid artery within 2 h after finishing cytotoxic edema induction in a dose of 50 mg/kg b.w.; into internal carotid artery 10 min after edema induction by BBBd in a dose of 50 mg/kg b.w.'?,"No, this sentence does not indirectly support the statement that hydrocortisone (MP) affects asthma. The sentence discusses the administration of MP in various ways in an experimental setting related to cytotoxic edema, but it does not mention or imply any effect on asthma." -8017440,Hydrocortisone affects obesity disorder,437,"On the other hand, daily administration of methylprednisolone and tenoxicam for 4 weeks caused increased inflammation and fibrosis and wasn't affective on protection of nerve physiomorphology.",False,"Is the triple 'Hydrocortisone affects obesity disorder' supported by the sentence: 'On the other hand, daily administration of methylprednisolone and tenoxicam for 4 weeks caused increased inflammation and fibrosis and wasn't affective on protection of nerve physiomorphology.'?","No, this sentence does not support the idea that hydrocortisone affects obesity disorder, directly or indirectly. The sentence discusses the effects of methylprednisolone and tenoxicam on inflammation and nerve physiomorphology, but it does not mention hydrocortisone or any related conditions such as obesity. Hydrocortisone is a type of corticosteroid hormone, while methylprednisolone is a synthetic glucocorticoid, so they have different chemical structures and mechanisms of action, although they may have some overlapping effects on inflammation, immune response, and metabolism. Therefore, it is not appropriate to infer any relationship between hydrocortisone and obesity based on this sentence alone." -7974249,Hydrocortisone affects Insulin resistance,438,Methylprednisolone was temporarily stopped while a broad work up for inflammatory and neoplastic causes was pursued.,False,Is the triple 'Hydrocortisone affects Insulin resistance' supported by the sentence: 'Methylprednisolone was temporarily stopped while a broad work up for inflammatory and neoplastic causes was pursued.'?,"No, this sentence does not provide direct support for the claim that hydrocortisone affects insulin resistance, nor does it indirectly support the claim through mentioning methylprednisolone, another corticosteroid drug. The sentence discusses a case where methylprednisolone was temporarily stopped for diagnostic purposes, but it does not provide any information about its effects on insulin resistance, nor does it compare it to hydrocortisone in this regard." -7366981,Hydrocortisone affects Hypoxemia,439,"Pneumocystis pneumonia induced by this dose of tacrolimus has been reported in many cases; however, we encountered a rare case of Pneumocystis pneumonia induced by low-dose tacrolimus and methylprednisolone.",False,"Is the triple 'Hydrocortisone affects Hypoxemia' supported by the sentence: 'Pneumocystis pneumonia induced by this dose of tacrolimus has been reported in many cases; however, we encountered a rare case of Pneumocystis pneumonia induced by low-dose tacrolimus and methylprednisolone.'?","No, this sentence does not provide support for the statement ""Hydrocortisone affects Hypoxemia"". The sentence discusses an instance of Pneumocystis pneumonia induced by low-dose tacrolimus and methylprednisolone, but it does not mention hydrocortisone or hypoxemia. Therefore, it does not provide indirect support for the initial statement." -7266667,Hydrocortisone affects dissociative amnesia,440,The increased interval in the administration of MP resulted in slightly greater pain and an increased prevalence of NeP.,False,Is the triple 'Hydrocortisone affects dissociative amnesia' supported by the sentence: 'The increased interval in the administration of MP resulted in slightly greater pain and an increased prevalence of NeP.'?,"No, this sentence does not provide any indirect support for the statement that hydrocortisone affects dissociative amnesia. The sentence discusses the effects of MP administration intervals on pain and neuropathic pain prevalence, but it does not mention hydrocortisone or dissociative amnesia." -27426083,Hydrocortisone produces HIV infectious disease,441,"We describe that high-dose methylprednisolone (20 mg/kg) can induce multifocal osteonecrosis (ON) in conjunction with thrombocytopenia, hypofibrinogenemia, and hyperlipemia.",False,"Is the triple 'Hydrocortisone produces HIV infectious disease' supported by the sentence: 'We describe that high-dose methylprednisolone (20 mg/kg) can induce multifocal osteonecrosis (ON) in conjunction with thrombocytopenia, hypofibrinogenemia, and hyperlipemia.'?","No, this sentence does not provide any support for the statement that hydrocortisone produces HIV infectious diseases, either directly or indirectly. The sentence discusses the side effects of high-dose methylprednisolone, which is a type of corticosteroid like hydrocortisone, but it does not mention or imply any connection to HIV infectious diseases." -24427531,Hydrocortisone produces cirrhosis of liver,442,"OBJECTIVE: To report the third published case, as of April 8, 2006, of methylprednisolone-induced toxic hepatitis.",False,"Is the triple 'Hydrocortisone produces cirrhosis of liver' supported by the sentence: 'OBJECTIVE: To report the third published case, as of April 8, 2006, of methylprednisolone-induced toxic hepatitis.'?","No, this statement does not provide indirect support for the claim that hydrocortisone produces cirrhosis of the liver. The sentence mentions methylprednisolone, which is a different glucocorticoid steroid hormone than hydrocortisone. While both hydrocortisone and methylprednisolone can have effects on the liver, this statement specifically discusses methylprednisolone-induced toxic hepatitis, not hydrocortisone-induced liver damage. Cirrhosis is a specific type of liver damage characterized by fibrosis, nodule formation, and loss of liver function, which is not explicitly mentioned in this statement. Therefore, this statement does not provide any evidence, direct or indirect, to support the claim about hydrocortisone-induced liver cirrhosis." -23738730,Hydrocortisone produces congenital adrenal hyperplasia,443,"To our knowledge, this is the first discussion considering the possibility that the methylprednisolone recommended by NASCIS may cause acute corticosteroid myopathy.",False,"Is the triple 'Hydrocortisone produces congenital adrenal hyperplasia' supported by the sentence: 'To our knowledge, this is the first discussion considering the possibility that the methylprednisolone recommended by NASCIS may cause acute corticosteroid myopathy.'?","No, this statement does not provide any indirect support for the claim that hydrocortisone produces congenital adrenal hyperplasia. The sentence discusses the potential side effects of methylprednisolone, recommended by NASCIS, causing acute corticosteroid myopathy, not hydrocortisone causing congenital adrenal hyperplasia." -20514012,"Hydrocortisone produces dermatitis, atopic",444,"However, high-dose steroids like dexamethasone or methylprednisolone had proven their clearcut anti-tumoral action.",False,"Is the triple 'Hydrocortisone produces dermatitis, atopic' supported by the sentence: 'However, high-dose steroids like dexamethasone or methylprednisolone had proven their clearcut anti-tumoral action.'?","No, this sentence does not provide indirect support for the statement that hydrocortisone produces dermatitis, atopic. The sentence discusses the anti-tumoral action of high-dose steroids like dexamethasone or methylprednisolone, whereas the initial statement is about hydrocortisone causing dermatitis, atopic. These two statements discuss different aspects (side effects vs therapeutic action) of different steroids (hydrocortisone vs dexamethasone/methylprednisolone)." -18924640,Hydrocortisone produces Inflammation,445,"Methylprednisolone increases some astrogliosis and inflammation biomarkers' levels; however, it did not affect the apoptotic biomarkers.",False,"Is the triple 'Hydrocortisone produces Inflammation' supported by the sentence: 'Methylprednisolone increases some astrogliosis and inflammation biomarkers' levels; however, it did not affect the apoptotic biomarkers.'?","No, this statement does not support the triple ""Hydrocortisone produces Inflammation"". The sentence discusses Methylprednisolone, not Hydrocortisone, and it mentions that Methylprednisolone increases some inflammation markers, but it does not mention Hydrocortisone at all, let alone state it causes inflammation directly or indirectly." -16473285,Hydrocortisone produces type 1 diabetes mellitus,446,Effect of Methylprednisolone on Inflammation and Coagulation in Patients with Severe COVID-19: A Retrospective Cohort Study.,False,Is the triple 'Hydrocortisone produces type 1 diabetes mellitus' supported by the sentence: 'Effect of Methylprednisolone on Inflammation and Coagulation in Patients with Severe COVID-19: A Retrospective Cohort Study.'?,"No, this statement is not supported by the provided sentence. The sentence discusses the effect of Methylprednisolone on inflammation and coagulation in patients with severe COVID-19, but it does not mention Hydrocortisone or its relationship to type 1 diabetes mellitus. Hydrocortisone and Methylprednisolone are both types of corticosteroids, but they are not identical, and one cannot be directly inferred from the other in this context." -15760263,Hydrocortisone produces toxic shock syndrome,447,"METHODS/DESIGN: This study is a 12-week, randomised, double-blind, placebo-controlled trial analysing the effects of high-dose intravenous methylprednisolone in very early SSc.",False,"Is the triple 'Hydrocortisone produces toxic shock syndrome' supported by the sentence: 'METHODS/DESIGN: This study is a 12-week, randomised, double-blind, placebo-controlled trial analysing the effects of high-dose intravenous methylprednisolone in very early SSc.'?","No, this statement does not indirectly support the claim that hydrocortisone produces toxic shock syndrome. The sentence describes a study on systemic sclerosis (SSc) using high-dose intravenous methylprednisolone, not hydrocortisone. Additionally, it does not mention anything about toxic shock syndrome, which is a rare but life-threatening condition often associated with certain types of bacterial infections, not corticosteroids like hydrocortisone or methylprednisolone." -15330155,Hydrocortisone produces chronic primary adrenal insufficiency,448,"Methods: The potential interferences Se@SiO2 nanocomposites may have to the therapeutic effect of methylprednisolone (MPS) were evaluated by classical therapeutic effect index of acute respiratory distress syndrome (ARDS), such as wet-to-dry weight ratio, inflammatory factors IL-1beta and TNF-alpha.",False,"Is the triple 'Hydrocortisone produces chronic primary adrenal insufficiency' supported by the sentence: 'Methods: The potential interferences Se@SiO2 nanocomposites may have to the therapeutic effect of methylprednisolone (MPS) were evaluated by classical therapeutic effect index of acute respiratory distress syndrome (ARDS), such as wet-to-dry weight ratio, inflammatory factors IL-1beta and TNF-alpha.'?","No, this statement does not indirectly support the claim that hydrocortisone produces chronic primary adrenal insufficiency. The methods described in this sentence involve evaluating the potential interferences of Se@SiO2 nanocomposites on the therapeutic effect of methylprednisolone (MPS) in acute respiratory distress syndrome (ARDS). Hydrocortisone is not mentioned in this sentence, nor is there any connection made to adrenal insufficiency." -14100936,Hydrocortisone produces Insulin resistance,449,Our case likely represents worsening of DON due to soft tissue swelling secondary to OR despite cover with IVMP in a patient previously responsive to IVMP alone.,True,Is the triple 'Hydrocortisone produces Insulin resistance' supported by the sentence: 'Our case likely represents worsening of DON due to soft tissue swelling secondary to OR despite cover with IVMP in a patient previously responsive to IVMP alone.'?,"Yes, this sentence could indirectly support the statement ""Hydrocortisone produces Insulin Resistance"". The sentence mentions a patient who was previously responsive to IVMP (intravenous methylprednisolone, a type of hydrocortisone) alone, but became less responsive due to soft tissue swelling secondary to OR (osteoradionecrosis) despite continued cover with IVMP. This suggests that long-term use of hydrocortisone (IVMP) may lead to insulin resistance, as prolonged steroid use is known to cause metabolic changes including insulin resistance. However, it's important to note that this is an indirect inference, and direct experimental evidence would be needed to confirm this relationship." -13891079,Hydrocortisone produces obesity disorder,450,[Treatment of invasive thymoma with myasthenia gravis: a case report responsive to azathioprine and methylprednisolone].,False,Is the triple 'Hydrocortisone produces obesity disorder' supported by the sentence: '[Treatment of invasive thymoma with myasthenia gravis: a case report responsive to azathioprine and methylprednisolone].'?,"No, this statement is not indirectly supported by the given sentence. The sentence discusses treatment of invasive thymoma with myasthenia gravis using azathioprine and methylprednisolone, but it does not mention hydrocortisone nor any link to obesity disorder." -13796050,Hydrocortisone produces adrenal cortex neoplasm,451,High-dose intravenous methylprednisolone is the first-line therapy for acute exacerbations of NMO.,False,Is the triple 'Hydrocortisone produces adrenal cortex neoplasm' supported by the sentence: 'High-dose intravenous methylprednisolone is the first-line therapy for acute exacerbations of NMO.'?,"No, this statement does not provide indirect support for the claim that hydrocortisone produces adrenal cortex neoplasm (a type of tumor). The sentence you provided suggests that high-dose intravenous methylprednisolone is used as a first-line therapy for acute exacerbations of Neuromyelitis Optica (NMO), a neurological disorder. Hydrocortisone is a type of steroid hormone used in various medical treatments, but there is no direct or indirect connection stated or implied between hydrocortisone and the development of adrenal cortex neoplasms in this sentence." -13783969,Hydrocortisone produces adrenocortical insufficiency,452,"CONCLUSION: Although the delayed administration of high-dose MP did not significantly increase the severity of pain or prevalence of NeP, it should still be avoided due to the increased risk of serious side effects.",False,"Is the triple 'Hydrocortisone produces adrenocortical insufficiency' supported by the sentence: 'CONCLUSION: Although the delayed administration of high-dose MP did not significantly increase the severity of pain or prevalence of NeP, it should still be avoided due to the increased risk of serious side effects.'?","No, this sentence does not provide indirect support for the statement that hydrocortisone produces adrenocortical insufficiency. The sentence discusses the administration of high-dose methylprednisolone (MP) and its potential side effects, but it does not mention hydrocortisone or adrenocortical insufficiency. Adrenocortical insufficiency is a condition where the adrenal glands do not produce enough corticosteroid hormones, such as cortisol (a type of hydrocortisone) due to various reasons like damage to the glands, autoimmune disorders, infections, etc., which is not discussed in this sentence." -13669597,Hydrocortisone produces asthma,453,Methylprednisolone has been used in other Th1 mediated diseases such as rheumatoid arthritis in an attempt to switch off the immune response and so we investigated the efficacy of three days of high dose (1 g) intravenous methylprednisolone at the start of prednisolone therapy in leprosy Type 1 reactions and nerve function impairment.,False,Is the triple 'Hydrocortisone produces asthma' supported by the sentence: 'Methylprednisolone has been used in other Th1 mediated diseases such as rheumatoid arthritis in an attempt to switch off the immune response and so we investigated the efficacy of three days of high dose (1 g) intravenous methylprednisolone at the start of prednisolone therapy in leprosy Type 1 reactions and nerve function impairment.'?,"No, this sentence does not indirectly support the claim that hydrocortisone produces asthma. The sentence discusses the use of methylprednisolone in rheumatoid arthritis and leprosy Type 1 reactions, not hydrocortisone in asthma. While hydrocortisone, methylprednisolone, and prednisolone are all corticosteroids, they have different properties and uses, and this sentence does not provide any information about hydrocortisone causing asthma." -12147996,Hydrocortisone produces Sepsis,454,Myelitis in these patients was not related to graft versus host disease or immune reconstitution and was responsive to intravenous methylprednisolone and cyclophosphamide.,False,Is the triple 'Hydrocortisone produces Sepsis' supported by the sentence: 'Myelitis in these patients was not related to graft versus host disease or immune reconstitution and was responsive to intravenous methylprednisolone and cyclophosphamide.'?,"No, this sentence does not support the claim that hydrocortisone produces sepsis. In fact, it suggests the opposite. The sentence mentions that intravenous methylprednisolone, which is a type of corticosteroid like hydrocortisone, was used to treat myelitis, indicating that these drugs can be used to manage certain conditions, not cause them. However, it's important to note that prolonged use of corticosteroids can suppress the immune system, making individuals more susceptible to infections, which could potentially lead to sepsis in some cases. But this sentence does not provide direct evidence for this causal relationship." -11989948,Hydrocortisone produces Hypoxemia,455,"We investigated the effects of YM264, WEB2086, methylprednisolone and ticlopidine on puromycin-induced nephropathy in the rat.",False,"Is the triple 'Hydrocortisone produces Hypoxemia' supported by the sentence: 'We investigated the effects of YM264, WEB2086, methylprednisolone and ticlopidine on puromycin-induced nephropathy in the rat.'?","No, this sentence does not provide support for the claim that hydrocortisone produces hypoxemia, directly or indirectly. The sentence discusses an investigation into the effects of several compounds on puromycin-induced nephropathy in rats, but it does not mention hydrocortisone, hypoxemia, or any relationship between them." -11730055,Hydrocortisone produces pneumonia,456,"The study strongly suggests that methylprednisolone has significant beneficial effects in human spinal cord injury, that these effects occur only when the drug is given within 8 hr, and that it helps even in patients with severe spinal cord injuries.",False,"Is the triple 'Hydrocortisone produces pneumonia' supported by the sentence: 'The study strongly suggests that methylprednisolone has significant beneficial effects in human spinal cord injury, that these effects occur only when the drug is given within 8 hr, and that it helps even in patients with severe spinal cord injuries.'?","No, this statement does not indirectly support the claim that hydrocortisone produces pneumonia. The study mentioned in the sentence discusses methylprednisolone, which is a different glucocorticoid drug than hydrocortisone. The study suggests beneficial effects for methylprednisolone in spinal cord injuries when given within 8 hours, which does not relate to hydrocortisone causing pneumonia." -8328567,Hydrocortisone produces prostate cancer,457,"Comparison of the effects of 2 doses of methylprednisolone on pain, swelling, and trismus after third molar surgery.",False,"Is the triple 'Hydrocortisone produces prostate cancer' supported by the sentence: 'Comparison of the effects of 2 doses of methylprednisolone on pain, swelling, and trismus after third molar surgery.'?","No, this statement does not provide any support for the claim that hydrocortisone produces prostate cancer. The sentence discusses the effects of methylprednisolone, not hydrocortisone, on pain, swelling, and trismus after third molar surgery. Therefore, it does not provide any indirect support for the claim about hydrocortisone and prostate cancer." -8077250,Hydrocortisone produces neoplasm,458,Steatohepatitis during methylprednisolone therapy for ulcerative colitis exacerbation.,False,Is the triple 'Hydrocortisone produces neoplasm' supported by the sentence: 'Steatohepatitis during methylprednisolone therapy for ulcerative colitis exacerbation.'?,"No, this sentence does not indirectly support the statement that hydrocortisone produces neoplasm. Methylprednisolone is not hydrocortisone, although they are both corticosteroids, they have different properties and uses. The sentence only mentions steatohepatitis during methylprednisolone therapy, not neoplasm (new and abnormal growth of tissue, such as a tumor)." -27711985,Hydrocortisone disrupts adrenocortical insufficiency,459,These results suggest that increasing the uric acid concentration may represent one of the possible mechanisms of action of methylprednisolone in multiple sclerosis.,False,Is the triple 'Hydrocortisone disrupts adrenocortical insufficiency' supported by the sentence: 'These results suggest that increasing the uric acid concentration may represent one of the possible mechanisms of action of methylprednisolone in multiple sclerosis.'?,"No, this sentence does not support the statement that hydrocortisone disrupts adrenocortical insufficiency. The sentence discusses methylprednisolone, not hydrocortisone, and its potential mechanism in multiple sclerosis through uric acid concentration, not adrenocortical insufficiency." -26428860,Hydrocortisone disrupts leukemia,460,"OBJECTIVE: Compare the therapeutic efficacy of an oral/metered-dose inhaler (oral/MDI) regimen to an intravenous/nebulizer (I.V./neb) regimen of methylprednisolone, cefuroxime, and inhaled albuterol and ipratropium bromide in patients hospitalized for exacerbations of chronic obstructive pulmonary disease (COPD).",False,"Is the triple 'Hydrocortisone disrupts leukemia' supported by the sentence: 'OBJECTIVE: Compare the therapeutic efficacy of an oral/metered-dose inhaler (oral/MDI) regimen to an intravenous/nebulizer (I.V./neb) regimen of methylprednisolone, cefuroxime, and inhaled albuterol and ipratropium bromide in patients hospitalized for exacerbations of chronic obstructive pulmonary disease (COPD).'?","No, this sentence does not provide any direct evidence to support the statement ""Hydrocortisone disrupts leukemia."" The sentence discusses a study comparing different treatment regimens for chronic obstructive pulmonary disease (COPD), including methylprednisolone, an alternative to hydrocortisone, but it does not mention hydrocortisone or leukemia." -26389045,Hydrocortisone disrupts neoplasm,461,"Similar to the CRPS clinical response to glucocorticoids, we now demonstrate that chronic hindpaw edema in the sciatic transection CRPS model is reversed by a continuous infusion of MP (3 mg/kg/day over 21 days), and this anti-edematous effect persists for at least 1 week after discontinuing MP.",False,"Is the triple 'Hydrocortisone disrupts neoplasm' supported by the sentence: 'Similar to the CRPS clinical response to glucocorticoids, we now demonstrate that chronic hindpaw edema in the sciatic transection CRPS model is reversed by a continuous infusion of MP (3 mg/kg/day over 21 days), and this anti-edematous effect persists for at least 1 week after discontinuing MP.'?","No, this sentence does not provide direct evidence to support the statement that hydrocortisone, a type of glucocorticoid, disrupts neoplasms (abnormal growths that may be benign or cancerous). The sentence discusses the effect of methylprednisolone (MP) on chronic hindpaw edema in a specific rat model for complex regional pain syndrome (CRPS). While both hydrocortisone and MP are glucocorticoids, they are not identical, and this study does not address their effects on neoplasms." -26128287,Hydrocortisone disrupts melanoma,462,STUDY OBJECTIVES: To assess whether IV methylprednisolone exerts a specific early effect on dyspnea in patients with an exacerbation of asthma.,False,Is the triple 'Hydrocortisone disrupts melanoma' supported by the sentence: 'STUDY OBJECTIVES: To assess whether IV methylprednisolone exerts a specific early effect on dyspnea in patients with an exacerbation of asthma.'?,"No, this statement does not provide any indirect support for the claim that hydrocortisone disrupts melanoma. The study objective is assessing the effect of IV methylprednisolone on dyspnea in patients with an exacerbation of asthma, which is unrelated to hydrocortisone and its potential impact on melanoma." -21020907,Hydrocortisone disrupts pneumonia,463,REVIEWER'S CONCLUSIONS: Cyclophosphamide regimen treatment is a form of care in neuropsychiatric involvement in systemic lupus erythematosus with no evidence to prove better effectiveness and safety when compared with methylprednisolone.,False,Is the triple 'Hydrocortisone disrupts pneumonia' supported by the sentence: 'REVIEWER'S CONCLUSIONS: Cyclophosphamide regimen treatment is a form of care in neuropsychiatric involvement in systemic lupus erythematosus with no evidence to prove better effectiveness and safety when compared with methylprednisolone.'?,"No, this sentence does not provide any indirect support for the statement that hydrocortisone disrupts pneumonia. The sentence discusses the effectiveness and safety of different treatments for neuropsychiatric involvement in systemic lupus erythematosus, namely cyclophosphamide regimen treatment, methylprednisolone, but it does not mention hydrocortisone or pneumonia." -15895489,Hydrocortisone disrupts obesity disorder,464,"RESULTS: Both methylprednisolone and dexamethasone significantly reduced swelling and trismus (P < .05, Kruskal-Wallis test), whereas the methylprednisolone group had significantly less pain (P < .05, Kruskal-Wallis test) and consumed a lower amount of analgesics (P < .05, chi2 test) during the early postoperative days.",False,"Is the triple 'Hydrocortisone disrupts obesity disorder' supported by the sentence: 'RESULTS: Both methylprednisolone and dexamethasone significantly reduced swelling and trismus (P < .05, Kruskal-Wallis test), whereas the methylprednisolone group had significantly less pain (P < .05, Kruskal-Wallis test) and consumed a lower amount of analgesics (P < .05, chi2 test) during the early postoperative days.'?","No, this sentence does not provide any indirect evidence to support the statement that ""hydrocortisone disrupts obesity disorder"". The sentence discusses the results of a study where methylprednisolone and dexamethasone were used in a postoperative setting to reduce swelling, trismus, pain, and analgesic consumption, but it does not mention hydrocortisone, let alone its potential role in obesity disorder." -15750557,Hydrocortisone disrupts injury,465,Methylprednisolone only inhibited granulocytopenia and thrombocytopenia when zymosan-activated serum or fibrinogen-depleted plasma were infused.,False,Is the triple 'Hydrocortisone disrupts injury' supported by the sentence: 'Methylprednisolone only inhibited granulocytopenia and thrombocytopenia when zymosan-activated serum or fibrinogen-depleted plasma were infused.'?,"No, this sentence does not indirectly support the statement that hydrocortisone disrupts injury. The sentence is discussing the effects of methylprednisolone on granulocytopenia and thrombocytopenia, not hydrocortisone. Furthermore, it is discussing these effects in specific conditions (zymosan-activated serum or fibrinogen-depleted plasma infusion), not in the context of injury disruption." -8865955,Hydrocortisone disrupts Inflammation,466,"In addition, we detected that sufentanil provided prolonged pain relief up to 24 h when compared with control, whereas when we combined sufentanil plus methylprednisolone, we found that it further reduced pain and use of analgesics when compared with sufentanil.",False,"Is the triple 'Hydrocortisone disrupts Inflammation' supported by the sentence: 'In addition, we detected that sufentanil provided prolonged pain relief up to 24 h when compared with control, whereas when we combined sufentanil plus methylprednisolone, we found that it further reduced pain and use of analgesics when compared with sufentanil.'?","No, this sentence does not indirectly support the statement ""Hydrocortisone disrupts Inflammation"". The sentence discusses the effects of sufentanil and methylprednisolone on pain relief, but it does not mention hydrocortisone or inflammation." -26205555,Hydrocortisone prevents neoplasm,467,These findings demonstrate that MP may suppress post-traumatic inflammatory reaction by inhibiting both the AP-1 and NF-kappaB transcription cascades via a GR mechanism.,False,Is the triple 'Hydrocortisone prevents neoplasm' supported by the sentence: 'These findings demonstrate that MP may suppress post-traumatic inflammatory reaction by inhibiting both the AP-1 and NF-kappaB transcription cascades via a GR mechanism.'?,"No, this sentence does not provide direct or indirect support for the statement ""Hydrocortisone prevents neoplasm"". The sentence discusses findings related to Myriocin (MP) suppressing inflammatory reactions through inhibition of certain transcription cascades via a glucocorticoid receptor (GR) mechanism, but it does not mention hydrocortisone, which is a type of corticosteroid hormone, nor does it mention any effects on preventing neoplasms (tumors)." -19342068,Hydrocortisone prevents obesity disorder,468,"This study assessed the effectiveness of a ganciclovir, methylprednisolone, and immunoglobulin combination (TAGMIC) therapy in decreasing cognitive impairment and mortality among patients with Japanese encephalitis.",False,"Is the triple 'Hydrocortisone prevents obesity disorder' supported by the sentence: 'This study assessed the effectiveness of a ganciclovir, methylprednisolone, and immunoglobulin combination (TAGMIC) therapy in decreasing cognitive impairment and mortality among patients with Japanese encephalitis.'?","No, this statement does not provide any direct or indirect support for the claim that hydrocortisone prevents obesity disorder. The study mentioned assesses the effectiveness of a specific therapy (TAGMIC) on cognitive impairment and mortality in patients with Japanese encephalitis, not on obesity disorders, nor does it mention hydrocortisone as part of the treatment." -19245686,Hydrocortisone prevents toxic shock syndrome,469,"From indirect comparisons, most interventions showed decreased risk of developing RA compared to placebo at 12 months, reaching statistical significance for methotrexate (OR 0.16 [95% CI 0.08, 0.33]) and intramuscular methylprednisolone (OR 0.72 [95% CI 0.53, 0.99]).",False,"Is the triple 'Hydrocortisone prevents toxic shock syndrome' supported by the sentence: 'From indirect comparisons, most interventions showed decreased risk of developing RA compared to placebo at 12 months, reaching statistical significance for methotrexate (OR 0.16 [95% CI 0.08, 0.33]) and intramuscular methylprednisolone (OR 0.72 [95% CI 0.53, 0.99]).'?","No, this sentence does not provide any indirect support for the statement that hydrocortisone prevents toxic shock syndrome. The sentence is discussing interventions for decreasing the risk of developing rheumatoid arthritis (RA) at 12 months, one of which is intramuscular methylprednisolone, not hydrocortisone. Additionally, it does not mention anything about toxic shock syndrome." -18758297,Hydrocortisone prevents injury,470,Treatment with a pulse of methylprednisolone reduced both abdominal pain and lesion size.,True,Is the triple 'Hydrocortisone prevents injury' supported by the sentence: 'Treatment with a pulse of methylprednisolone reduced both abdominal pain and lesion size.'?,"Yes, this statement can be interpreted as indirectly supporting the idea that hydrocortisone prevents injury. Methylprednisolone is a type of corticosteroid, similar to hydrocortisone, and it has been shown to reduce both abdominal pain and lesion size, which could be interpreted as preventing further injury. However, it is important to note that this is an indirect inference, as methylprednisolone is not exactly the same as hydrocortisone, and the specific conditions under which it was used may not directly apply to hydrocortisone." -17956690,Hydrocortisone prevents Sepsis,471,Methylprednisolone prevents propranolol-induced airway hyperreactivity in the Basenji-greyhound dog.,False,Is the triple 'Hydrocortisone prevents Sepsis' supported by the sentence: 'Methylprednisolone prevents propranolol-induced airway hyperreactivity in the Basenji-greyhound dog.'?,"No, this sentence does not indirectly support the statement that Hydrocortisone prevents sepsis based on the information given about Methylprednisolone preventing propranolol-induced airway hyperreactivity in Basenji-greyhound dogs. - The two statements refer to different substances (Hydrocortisone vs Methylprednisolone) and different conditions (sepsis vs propranolol-induced airway hyperreactivity). - Therefore, it would be inappropriate to make such an inference without additional data connecting these substances and conditions." -16963888,Hydrocortisone prevents adrenocortical insufficiency,472,Administration of methylprednisolone to prevent severe ovarian hyperstimulation syndrome in patients undergoing in vitro fertilization.,True,Is the triple 'Hydrocortisone prevents adrenocortical insufficiency' supported by the sentence: 'Administration of methylprednisolone to prevent severe ovarian hyperstimulation syndrome in patients undergoing in vitro fertilization.'?,"Yes, this statement can be seen as indirectly supportive because both hydrocortisone and methylprednisolone are types of corticosteroids, which are commonly used to suppress the immune system and reduce inflammation. In this case, methylprednisolone is used to prevent severe ovarian hyperstimulation syndrome, suggesting that corticosteroids like hydrocortisone could potentially have similar preventative effects in relation to adrenocortical insufficiency, given their shared mechanism of action in modulating immune response and inflammation. However, this is an indirect inference, as it does not directly mention hydrocortisone nor adrenocortical insufficiency, but it does suggest potential similarities between different corticosteroids in terms of their clinical applications in preventing certain conditions related to hormonal imbalances in the body." -15550113,Hydrocortisone prevents Inflammation,473,"Combined methylprednisolone, bupivacaine and morphine reduced pain, joint swelling, time of immobilization, duration of sick leave and return to sports after the arthroscopic procedure.",True,"Is the triple 'Hydrocortisone prevents Inflammation' supported by the sentence: 'Combined methylprednisolone, bupivacaine and morphine reduced pain, joint swelling, time of immobilization, duration of sick leave and return to sports after the arthroscopic procedure.'?","Yes, this statement can be seen as indirectly supportive of the claim that hydrocortisone prevents inflammation. This is because methylprednisolone, which is mentioned in the sentence, is a type of corticosteroid similar to hydrocortisone. Corticosteroids like these have anti-inflammatory effects, which is why they are often used in medical procedures to reduce pain, swelling, and other symptoms associated with inflammation. Therefore, it stands to reason that hydrocortisone, being another corticosteroid, could have similar anti-inflammatory effects, thus supporting the claim. However, this is an indirect inference, as hydrocortisone is not specifically mentioned in the sentence, nor is the exact mechanism behind its potential anti-inflammatory effects explained in this context." -15540854,Hydrocortisone prevents pneumonia,474,Forty-eight patients who underwent bone marrow transplantation (BMT) from serologically HLA-matched unrelated donors received tacrolimus (FK506) alone or with methotrexate (MTX) and/or methylprednisolone (mPSL) to prevent graft-versus-host disease (GVHD).,False,Is the triple 'Hydrocortisone prevents pneumonia' supported by the sentence: 'Forty-eight patients who underwent bone marrow transplantation (BMT) from serologically HLA-matched unrelated donors received tacrolimus (FK506) alone or with methotrexate (MTX) and/or methylprednisolone (mPSL) to prevent graft-versus-host disease (GVHD).'?,"No, this statement does not indirectly support the claim that hydrocortisone prevents pneumonia. The sentence discusses the use of immunosuppressive drugs (tacrolimus, methotrexate, and methylprednisolone) in bone marrow transplantation patients to prevent graft-versus-host disease (GVHD). Hydrocortisone is not mentioned in this sentence, nor is there any connection made to preventing pneumonia." -14020540,Hydrocortisone prevents bronchopulmonary dysplasia,475,"Thus, calpeptin and methylprednisolone are found to be neuroprotective in SCI.",False,"Is the triple 'Hydrocortisone prevents bronchopulmonary dysplasia' supported by the sentence: 'Thus, calpeptin and methylprednisolone are found to be neuroprotective in SCI.'?","No, this sentence does not indirectly support the statement that hydrocortisone prevents bronchopulmonary dysplasia. The sentence discusses the neuroprotective effects of calpeptin and methylprednisolone in spinal cord injuries (SCI), not their effects on bronchopulmonary dysplasia. Hydrocortisone is not even mentioned in this sentence, so it cannot provide indirect support for the original statement." -13075196,Hydrocortisone prevents atrial fibrillation,476,"Methylprednisolone prevents the development of autotomy and neuropathic edema in rats, but has no effect on nociceptive thresholds.",False,"Is the triple 'Hydrocortisone prevents atrial fibrillation' supported by the sentence: 'Methylprednisolone prevents the development of autotomy and neuropathic edema in rats, but has no effect on nociceptive thresholds.'?","No, this statement does not indirectly support the idea that hydrocortisone prevents atrial fibrillation. The sentence mentions methylprednisolone, not hydrocortisone, and it discusses its effects on rats, not humans, nor on atrial fibrillation. Hydrocortisone and methylprednisolone are both glucocorticoids, but they have different properties, uses, and effects on various biological systems, so their effects cannot be generalized." -12187318,Hydrocortisone prevents Insulin resistance,477,Chronically impaired renal function and the use of methylprednisolone may be the risk factors for SP.,False,Is the triple 'Hydrocortisone prevents Insulin resistance' supported by the sentence: 'Chronically impaired renal function and the use of methylprednisolone may be the risk factors for SP.'?,"No, this statement does not indirectly support the claim that hydrocortisone prevents insulin resistance. The sentence mentions methylprednisolone, not hydrocortisone, as a potential risk factor for some condition (SP). Additionally, there is no mention of insulin resistance in this sentence, so it does not provide any evidence for a relationship between hydrocortisone and insulin resistance." -14643692,Hydrocortisone exacerbates Sepsis,478,"Because a common therapy for acute spinal cord injury is the use of an antiinflammatory synthetic glucocorticoid (methylprednisolone), we sought to determine mechanisms contributing to inflammation shortly after acute injury.",True,"Is the triple 'Hydrocortisone exacerbates Sepsis' supported by the sentence: 'Because a common therapy for acute spinal cord injury is the use of an antiinflammatory synthetic glucocorticoid (methylprednisolone), we sought to determine mechanisms contributing to inflammation shortly after acute injury.'?","Yes, indirectly supported. The rationale behind this is that methylprednisolone is an anti-inflammatory synthetic glucocorticoid, similar to hydrocortisone, which is used to treat acute spinal cord injury, hinting at an inflammation-related mechanism in acute injury cases, thus implying hydrocortisone might exacerbate sepsis, an inflammatory condition, due to its immunosuppressive properties. However, it is important to note that this is an indirect inference based on the provided sentence, as it does not explicitly mention hydrocortisone, sepsis, or their relationship." -8122784,Hydrocortisone exacerbates obesity disorder,479,"Combined treatments of rG-CSF with cefotaxime, cefazolin, fosfomycin, gentamicin or amphotericin B were evaluated in systemic infections with Pseudomonas aeruginosa, Escherichia coli, Serratia marcescens, Staphylococcus aureus and Candida albicans in leucopenic mice induced by pretreatment with cyclophosphamide.",False,"Is the triple 'Hydrocortisone exacerbates obesity disorder' supported by the sentence: 'Combined treatments of rG-CSF with cefotaxime, cefazolin, fosfomycin, gentamicin or amphotericin B were evaluated in systemic infections with Pseudomonas aeruginosa, Escherichia coli, Serratia marcescens, Staphylococcus aureus and Candida albicans in leucopenic mice induced by pretreatment with cyclophosphamide.'?","No, this sentence does not provide any direct or indirect support for the statement ""Hydrocortisone exacerbates obesity disorder"". The sentence discusses the effects of combined treatments of rG-CSF with various antibiotics and antifungal agents on systemic infections in leucopenic mice induced by pretreatment with cyclophosphamide, but it does not mention hydrocortisone, obesity, or any related disorders." -25411585,Hydrocortisone predisposes atrial fibrillation,480,"One such marker, CTX-M-15, expressed by Enterobacteriaceae produces beta-lactamases, which hydrolyze the cephalosporin group of antibiotics, such as cefotaxime, used in the treatment of both Gram-positive and negative bacterial infections.",False,"Is the triple 'Hydrocortisone predisposes atrial fibrillation' supported by the sentence: 'One such marker, CTX-M-15, expressed by Enterobacteriaceae produces beta-lactamases, which hydrolyze the cephalosporin group of antibiotics, such as cefotaxime, used in the treatment of both Gram-positive and negative bacterial infections.'?","No, this sentence does not provide any indirect support for the statement that hydrocortisone predisposes to atrial fibrillation. The sentence discusses the role of CTX-M-15, an enzyme produced by certain bacteria, in hydrolyzing cephalosporin antibiotics, but it does not mention hydrocortisone or atrial fibrillation." -19755964,Hydrocortisone predisposes Sepsis,481,"CONS, Staphylococcus aureus, Enterococci, Escherichia coli, Klebsiella and Enterobacter represented 91.9% of LOS episodes and were susceptible to vancomycin and cefotaxime (96.1%), vancomycin and gentamicin (97.0%) and cloxacillin and gentamicin (38.1%).",False,"Is the triple 'Hydrocortisone predisposes Sepsis' supported by the sentence: 'CONS, Staphylococcus aureus, Enterococci, Escherichia coli, Klebsiella and Enterobacter represented 91.9% of LOS episodes and were susceptible to vancomycin and cefotaxime (96.1%), vancomycin and gentamicin (97.0%) and cloxacillin and gentamicin (38.1%).'?","No, this sentence does not provide any direct or indirect support for the statement ""Hydrocortisone predisposes Sepsis"". This sentence discusses antibiotic susceptibility patterns in certain bacterial species related to Lower Respiratory Tract Infections (LOS), but it does not mention hydrocortisone, sepsis, or any relationship between them." -13712588,Hydrocortisone predisposes injury,482,"The protective effect of cefotaxime, aztreonam and gentamicin in peritonitis induced by E. coli alone or combined with B. fragilis was evaluated by analysing mortality at 24 and 48 h after bacterial inoculation and treating the animals with two doses of each antibiotic.",False,"Is the triple 'Hydrocortisone predisposes injury' supported by the sentence: 'The protective effect of cefotaxime, aztreonam and gentamicin in peritonitis induced by E. coli alone or combined with B. fragilis was evaluated by analysing mortality at 24 and 48 h after bacterial inoculation and treating the animals with two doses of each antibiotic.'?","No, this sentence does not provide any direct or indirect support for the statement “Hydrocortisone predisposes injury.” The sentence is discussing the protective effects of certain antibiotics in peritonitis induced by E. coli, either alone or in combination with B. fragilis, as determined by mortality rates at specific time points after bacterial inoculation and antibiotic treatment. The concept presented here is not related to hydrocortisone, its use, effects, or potential to predispose to injury." -12555774,Hydrocortisone predisposes toxic shock syndrome,483,"HR 810 had more potent protective effect than ceftazidime (CAZ), cefoperazone (CPZ), and cefotaxime (CTX) on systemic infections induced by Escherichia coli Ec-31, Staphylococcus aureus SMITH, and Serratia marcescens Sm-6 in mice.",False,"Is the triple 'Hydrocortisone predisposes toxic shock syndrome' supported by the sentence: 'HR 810 had more potent protective effect than ceftazidime (CAZ), cefoperazone (CPZ), and cefotaxime (CTX) on systemic infections induced by Escherichia coli Ec-31, Staphylococcus aureus SMITH, and Serratia marcescens Sm-6 in mice.'?","No, this sentence does not indirectly support the idea that hydrocortisone predisposes to toxic shock syndrome. The sentence discusses the potency of certain antibiotics against infections in mice, while the initial statement is about hydrocortisone and toxic shock syndrome, which is not mentioned in this sentence." -11782928,Hydrocortisone predisposes Inflammation,484,"1,480 patients, undergoing elective orthopedic and traumatic surgery, received intragluteal injections of ceftriaxone (Rocephin) to prevent bacterial infections.",False,"Is the triple 'Hydrocortisone predisposes Inflammation' supported by the sentence: '1,480 patients, undergoing elective orthopedic and traumatic surgery, received intragluteal injections of ceftriaxone (Rocephin) to prevent bacterial infections.'?","No, this sentence does not provide support for the statement ""Hydrocortisone predisposes Inflammation"". The sentence mentions ceftriaxone (Rocephin) injections for preventing bacterial infections in surgical patients, but it does not mention hydrocortisone, inflammation, or any connection between them." -10520517,Hydrocortisone predisposes obesity disorder,485,Proceedings: A double blind trial of carbenoxolone and geranyl farnesylacetate in gastric ulcer.,False,Is the triple 'Hydrocortisone predisposes obesity disorder' supported by the sentence: 'Proceedings: A double blind trial of carbenoxolone and geranyl farnesylacetate in gastric ulcer.'?,"No, this sentence does not provide any support for the idea that hydrocortisone predisposes to obesity disorder, directly or indirectly. The sentence discusses a double blind trial of carbenoxolone and geranyl farnesylacetate in gastric ulcer, which is unrelated to hydrocortisone or obesity disorder." -8615556,Hydrocortisone predisposes dissociative amnesia,486,A controlled double-blind study was performed in 17 institutes using gefarnate as a control drug in order to investigate the therapeutic effect and safety of pirenzepine dihydrochloride (LS 519) in duodenal ulcer.,False,Is the triple 'Hydrocortisone predisposes dissociative amnesia' supported by the sentence: 'A controlled double-blind study was performed in 17 institutes using gefarnate as a control drug in order to investigate the therapeutic effect and safety of pirenzepine dihydrochloride (LS 519) in duodenal ulcer.'?,"No, this statement does not provide any indirect support for the claim that hydrocortisone predisposes dissociative amnesia. The study mentioned in this statement is investigating the therapeutic effect and safety of pirenzepine dihydrochloride (LS 519) in duodenal ulcer, not about hydrocortisone or its effects on dissociative amnesia." -8552834,Hydrocortisone predisposes asthma,487,Gefarnate at 300 mg/kg (p.o.) significantly inhibited phenylbutazone-induced gastric ulcers in rats but had no effect on other ulcer models.,False,Is the triple 'Hydrocortisone predisposes asthma' supported by the sentence: 'Gefarnate at 300 mg/kg (p.o.) significantly inhibited phenylbutazone-induced gastric ulcers in rats but had no effect on other ulcer models.'?,"No, this statement does not provide any support for the claim that hydrocortisone predisposes to asthma, directly or indirectly. The sentence discusses the effects of Gefarnate on gastric ulcers in rats, which is not related to hydrocortisone or asthma." -8002300,Hydrocortisone predisposes Insulin resistance,488,We tested streptomycin (ST) and neomycin (NEO) as analgesic agents applied in situ in rat paw inflammation caused by formalin or carrageenan administration.,False,Is the triple 'Hydrocortisone predisposes Insulin resistance' supported by the sentence: 'We tested streptomycin (ST) and neomycin (NEO) as analgesic agents applied in situ in rat paw inflammation caused by formalin or carrageenan administration.'?,"No, this sentence does not provide support for the claim that hydrocortisone predisposes insulin resistance. The sentence discusses the use of streptomycin and neomycin as analgesic agents in rat paw inflammation, while the claim is about hydrocortisone and insulin resistance. There is no indirect link between these two statements." -7960726,Hydrocortisone predisposes pneumonia,489,[ON THE ACTION OF A NEOMYCIN AND THIOPENICOL PREPARATION IN EXPERIMENTAL BURNS].,False,Is the triple 'Hydrocortisone predisposes pneumonia' supported by the sentence: '[ON THE ACTION OF A NEOMYCIN AND THIOPENICOL PREPARATION IN EXPERIMENTAL BURNS].'?,"No, this statement is not supported by the provided sentence. The sentence discusses an experiment on burns using neomycin and thiopenicol, it does not mention hydrocortisone, pneumonia, or any relationship between them." -27228384,Methylprednisolone related to Crohn disease,490,"Therefore, we investigated the effect of long-term exposure of an antibiotic cocktail composed of Vancomycin, Neomycin, and Streptomycin, on tumor development and progression in the ApcMin/+ mouse, an established genetic model for familial adenomatous polyposis.",False,"Is the triple 'Methylprednisolone related to Crohn disease' supported by the sentence: 'Therefore, we investigated the effect of long-term exposure of an antibiotic cocktail composed of Vancomycin, Neomycin, and Streptomycin, on tumor development and progression in the ApcMin/+ mouse, an established genetic model for familial adenomatous polyposis.'?","No, this sentence does not provide any direct or indirect support for a relationship between Methylprednisolone and Crohn disease. The sentence discusses an investigation into the effect of an antibiotic cocktail on tumor development and progression in a specific mouse model for familial adenomatous polyposis, but it does not mention Methylprednisolone or Crohn disease." -26974005,Methylprednisolone related to hematopoietic and lymphoid system neoplasm,491,Ultrahigh doses of gentamicin and clinically relevant doses of neomycin affect inflammation and angiogenesis in in vivo and in vitro models.,False,Is the triple 'Methylprednisolone related to hematopoietic and lymphoid system neoplasm' supported by the sentence: 'Ultrahigh doses of gentamicin and clinically relevant doses of neomycin affect inflammation and angiogenesis in in vivo and in vitro models.'?,"No, there is no direct or indirect support provided in this sentence for methylprednisolone being related to hematopoietic and lymphoid system neoplasm. The sentence discusses the effects of gentamicin and neomycin on inflammation and angiogenesis, but it does not mention methylprednisolone or any relevant neoplasms in this context." -26513818,Methylprednisolone related to B-cell chronic lymphocytic leukemia,492,"Biodegradable polyaspartamide (PASPAM) was grafted with several functional groups to implement diverse roles-octadecylamine (C 18 ) for nano-aggregate formation, dopamine (DOPA) for adhesive function, neomycin (NEO) for inhibition of bacterial infection.",False,"Is the triple 'Methylprednisolone related to B-cell chronic lymphocytic leukemia' supported by the sentence: 'Biodegradable polyaspartamide (PASPAM) was grafted with several functional groups to implement diverse roles-octadecylamine (C 18 ) for nano-aggregate formation, dopamine (DOPA) for adhesive function, neomycin (NEO) for inhibition of bacterial infection.'?","No, this sentence does not provide any support for a relationship between Methylprednisolone and B-cell chronic lymphocytic leukemia. The sentence discusses the grafting of functional groups onto polyaspartamide (PASPAM) for various roles, but it does not mention Methylprednisolone or B-cell chronic lymphocytic leukemia." -26050805,Methylprednisolone related to ankylosing spondylitis,493,Kaposi's sarcoma-associated herpesvirus-positive primary effusion lymphoma tumor formation in NOD/SCID mice is inhibited by neomycin and neamine blocking angiogenin's nuclear translocation.,False,Is the triple 'Methylprednisolone related to ankylosing spondylitis' supported by the sentence: 'Kaposi's sarcoma-associated herpesvirus-positive primary effusion lymphoma tumor formation in NOD/SCID mice is inhibited by neomycin and neamine blocking angiogenin's nuclear translocation.'?,"No, this statement does not provide any indirect evidence for a relationship between Methylprednisolone and ankylosing spondylitis. The sentence discusses the inhibition of Kaposi's sarcoma-associated herpesvirus-positive primary effusion lymphoma tumor formation in NOD/SCID mice by neomycin and neamine, which blocks angiogenin's nuclear translocation, but it does not mention Methylprednisolone or ankylosing spondylitis." -25845844,Methylprednisolone related to breast neoplasm,494,Neomycin and the combination of neomycin and bacitracin in the prevention of bacterial infection in surgery of the colon and/or rectum.,False,Is the triple 'Methylprednisolone related to breast neoplasm' supported by the sentence: 'Neomycin and the combination of neomycin and bacitracin in the prevention of bacterial infection in surgery of the colon and/or rectum.'?,"No, this statement does not provide any support for a relationship between Methylprednisolone and breast neoplasm. The sentence mentions Neomycin and Bacitracin, which are antibiotics used in surgery of the colon and/or rectum for preventing bacterial infections. Methylprednisolone is a corticosteroid often used for its anti-inflammatory effects, and it does not have any direct or indirect connection to breast neoplasm based on this sentence." -25642837,Methylprednisolone related to dermatomyositis,495,Results of salvage therapy with mini-hyper-CVD and inotuzumab ozogamicin with or without blinatumomab in pre-B acute lymphoblastic leukemia.,False,Is the triple 'Methylprednisolone related to dermatomyositis' supported by the sentence: 'Results of salvage therapy with mini-hyper-CVD and inotuzumab ozogamicin with or without blinatumomab in pre-B acute lymphoblastic leukemia.'?,"No, the sentence does not provide any information supporting a relationship between Methylprednisolone and dermatomyositis. The sentence discusses salvage therapy for pre-B acute lymphoblastic leukemia using mini-hyper-CVD, inotuzumab ozogamicin, and potentially blinatumomab, but it does not mention Methylprednisolone or dermatomyositis." -25328503,Methylprednisolone related to Meniere disease,496,"The impressive clinical success of the continuously intravenously infused T cell-redirecting bispecific antibody (T-bsAb) blinatumomab (anti-CD19 x anti-CD3), and of engineered T cells expressing anti-CD19 chimeric antigen receptors (CAR-T cells) in hematological malignancies, has led to renewed interest in a novel cancer immunotherapy strategy that combines features of antibody- and cell-based therapies.",False,"Is the triple 'Methylprednisolone related to Meniere disease' supported by the sentence: 'The impressive clinical success of the continuously intravenously infused T cell-redirecting bispecific antibody (T-bsAb) blinatumomab (anti-CD19 x anti-CD3), and of engineered T cells expressing anti-CD19 chimeric antigen receptors (CAR-T cells) in hematological malignancies, has led to renewed interest in a novel cancer immunotherapy strategy that combines features of antibody- and cell-based therapies.'?","No, this sentence does not provide any information connecting Methylprednisolone, which is a corticosteroid medication, with Meniere disease, which is an inner ear disorder. The sentence discusses advances in cancer immunotherapy using T cell-redirecting bispecific antibodies (T-bsAb) and chimeric antigen receptor (CAR) T cells in hematological malignancies, but it does not mention Methylprednisolone or its relation to Meniere disease." -24759961,Methylprednisolone related to non-Hodgkin lymphoma,497,Blinatumomab and inotuzumab ozogamycin represent promising alternatives to conventional chemotherapy in acute lymphoblastic leukaemia (ALL).,False,Is the triple 'Methylprednisolone related to non-Hodgkin lymphoma' supported by the sentence: 'Blinatumomab and inotuzumab ozogamycin represent promising alternatives to conventional chemotherapy in acute lymphoblastic leukaemia (ALL).'?,"No, this sentence does not provide any support for a relationship between Methylprednisolone and non-Hodgkin lymphoma. The sentence discusses Blinatumomab and Inotuzumab Ozogamycin as alternatives to conventional chemotherapy in acute lymphoblastic leukaemia (ALL), but it does not mention Methylprednisolone or non-Hodgkin lymphoma." -24691450,Methylprednisolone related to plantar fasciitis,498,Efficacy of ciprofloxacin and dexamethasone in experimental pseudomonas endophthalmitis.,False,Is the triple 'Methylprednisolone related to plantar fasciitis' supported by the sentence: 'Efficacy of ciprofloxacin and dexamethasone in experimental pseudomonas endophthalmitis.'?,"No, this sentence does not provide any support for a relationship between Methylprednisolone and plantar fasciitis. The sentence discusses the efficacy of ciprofloxacin and dexamethasone in experimental pseudomonas endophthalmitis, which is an eye condition. Methylprednisolone is a type of steroid medication, and while it is true that steroids can be used in the treatment of inflammation associated with conditions like plantar fasciitis, this sentence does not mention or imply any connection between Methylprednisolone and plantar fasciitis." -24586108,Methylprednisolone related to alcoholic hepatitis,499,CONCLUSIONS: Combination therapy of adalimumab and ciprofloxacin is more effective than adalimumab monotherapy to achieve fistula closure in CD.,False,Is the triple 'Methylprednisolone related to alcoholic hepatitis' supported by the sentence: 'CONCLUSIONS: Combination therapy of adalimumab and ciprofloxacin is more effective than adalimumab monotherapy to achieve fistula closure in CD.'?,"No, this statement does not provide any support for a relationship between Methylprednisolone and alcoholic hepatitis. The conclusion is about the effectiveness of combination therapy (adalimumab and ciprofloxacin) versus monotherapy (adalimumab alone) in achieving fistula closure in Crohn's disease (CD). There is no mention of Methylprednisolone, alcohol, or hepatitis in this sentence." -24559507,Methylprednisolone related to respiratory system disorder,500,"Tested substances displayed inhibitory effect towards E. coli DNA gyrase, though less than ciprofloxacin.",False,"Is the triple 'Methylprednisolone related to respiratory system disorder' supported by the sentence: 'Tested substances displayed inhibitory effect towards E. coli DNA gyrase, though less than ciprofloxacin.'?","No, this sentence does not provide any indirect support for the relationship between Methylprednisolone and respiratory system disorder. The sentence is discussing the inhibitory effect of tested substances on E. coli DNA gyrase, which is unrelated to Methylprednisolone or any respiratory system disorder." -23573980,Methylprednisolone related to pneumonia,1,Evaluation of granulated fenbendazole (22.2%) against induced and naturally occurring helminth infections in cats.,False,Is the triple 'Methylprednisolone related to pneumonia' supported by the sentence: 'Evaluation of granulated fenbendazole (22.2%) against induced and naturally occurring helminth infections in cats.'?,"No, this sentence does not provide any support for a relationship between Methylprednisolone and pneumonia. The sentence discusses granulated fenbendazole, an anti-parasitic drug, being evaluated against helminth infections in cats, which is not directly relevant to Methylprednisolone, which is a corticosteroid, nor pneumonia, an inflammatory condition of the lung." -23514846,Methylprednisolone related to carpal tunnel syndrome,2,Fenbendazole resistance in O. ostertagi was confirmed with a total treatment failure in reducing worm burden: efficacy of 0%.,False,Is the triple 'Methylprednisolone related to carpal tunnel syndrome' supported by the sentence: 'Fenbendazole resistance in O. ostertagi was confirmed with a total treatment failure in reducing worm burden: efficacy of 0%.'?,"No, this sentence does not provide any support for a relationship between Methylprednisolone and carpal tunnel syndrome. The sentence discusses Fenbendazole resistance in O. ostertagi, which is an animal parasite, not a human condition like carpal tunnel syndrome, nor does it mention Methylprednisolone, which is a corticosteroid used for various conditions including inflammation, allergies, and autoimmune diseases, but not directly associated with carpal tunnel syndrome treatment." -23364897,Methylprednisolone related to West syndrome,3,Symptoms of perianal itching and visualization of visible motile worms persisted for 6 months despite being treated with multiple courses of albendazole causing a lot of frustration and distress to the caregivers.,False,Is the triple 'Methylprednisolone related to West syndrome' supported by the sentence: 'Symptoms of perianal itching and visualization of visible motile worms persisted for 6 months despite being treated with multiple courses of albendazole causing a lot of frustration and distress to the caregivers.'?,"No, this sentence does not provide any indirect support for the statement ""Methylprednisolone is related to West syndrome."" The sentence discusses symptoms of perianal itching and visualization of visible motile worms, which were treated with multiple courses of albendazole, causing frustration and distress to caregivers. There is no mention of Methylprednisolone, West syndrome, or any connection between them in this sentence." -22495910,Methylprednisolone related to myocarditis,4,"Ovicidal effects of albendazole in human ascariasis, ancylostomiasis and trichuriasis.",False,"Is the triple 'Methylprednisolone related to myocarditis' supported by the sentence: 'Ovicidal effects of albendazole in human ascariasis, ancylostomiasis and trichuriasis.'?","No, this statement does not provide any support for a relationship between Methylprednisolone and myocarditis. The sentence discusses the ovicidal effects of albendazole on certain types of parasitic infections in humans, namely ascariasis, ancylostomiasis, and trichuriasis. Methylprednisolone is a corticosteroid used primarily for its anti-inflammatory effects, and myocarditis is an inflammation of the heart muscle, but there is no connection between these concepts in this sentence." -22175056,Methylprednisolone related to myopathy,5,"A combination of drugs Ivermectin, Diethylcarbamazine citrate and Albendazole is recommended by WHO to accelerate the Global Programme to Eliminate Lymphatic Filariasis (GPELF).",False,"Is the triple 'Methylprednisolone related to myopathy' supported by the sentence: 'A combination of drugs Ivermectin, Diethylcarbamazine citrate and Albendazole is recommended by WHO to accelerate the Global Programme to Eliminate Lymphatic Filariasis (GPELF).'?","No, this sentence does not provide any indirect support for a relationship between Methylprednisolone and myopathy. The sentence mentions three drugs recommended by WHO for eliminating lymphatic filariasis, but it does not mention Methylprednisolone nor any condition like myopathy." -20879022,Methylprednisolone related to Pain,6,Effect of albendazole in experimental toxocariasis of mice.,False,Is the triple 'Methylprednisolone related to Pain' supported by the sentence: 'Effect of albendazole in experimental toxocariasis of mice.'?,"No, because there is no direct or indirect mention of Methylprednisolone, pain, or any relationship between them in this sentence about albendazole in experimental toxocariasis in mice." -20342058,Methylprednisolone related to chronic progressive multiple sclerosis,7,"Given the low helminth prevalence in our children, the effect of albendazole on malaria is likely to be direct.",False,"Is the triple 'Methylprednisolone related to chronic progressive multiple sclerosis' supported by the sentence: 'Given the low helminth prevalence in our children, the effect of albendazole on malaria is likely to be direct.'?","No, this sentence does not provide indirect support for a relationship between Methylprednisolone and chronic progressive multiple sclerosis, nor does it mention any connection between these entities and albendazole. The sentence discusses the potential direct effect of albendazole on malaria due to low helminth prevalence in children, which is unrelated to Methylprednisolone and multiple sclerosis." -20290784,Methylprednisolone related to membranous glomerulonephritis,8,"Mass co-administration of ivermectin and albendazole by the LFEP had a significant effect on STH, which was further amplified by treatment with praziquantel and albendazole 4 months later.",False,"Is the triple 'Methylprednisolone related to membranous glomerulonephritis' supported by the sentence: 'Mass co-administration of ivermectin and albendazole by the LFEP had a significant effect on STH, which was further amplified by treatment with praziquantel and albendazole 4 months later.'?","No, this sentence does not provide any support for a relationship between Methylprednisolone and membranous glomerulonephritis. The sentence discusses the effects of ivermectin, albendazole, and praziquantel on Strongyloides stercoralis (STH), but it does not mention Methylprednisolone or membranous glomerulonephritis." -20286711,Methylprednisolone related to neuromyelitis optica,9,The effect of single dose ivermectin alone or in combination with albendazole on Wuchereria bancrofti infection in primary school children in Tanzania.,False,Is the triple 'Methylprednisolone related to neuromyelitis optica' supported by the sentence: 'The effect of single dose ivermectin alone or in combination with albendazole on Wuchereria bancrofti infection in primary school children in Tanzania.'?,"No, the sentence does not provide any support for a relationship between Methylprednisolone and neuromyelitis optica. The sentence discusses the effect of ivermectin alone or in combination with albendazole on Wuchereria bancrofti infection in primary school children in Tanzania, which is unrelated to Methylprednisolone and neuromyelitis optica." -19340184,Methylprednisolone related to chronic obstructive pulmonary disease,10,"Additionally, compared with albendazole, it resulted in a significant reduction in adult worm and total larval counts; moreover, it caused a decrease in the number of larvae deposited in muscles, with a highly significant decrease in the inflammatory cell infiltrate around the larvae and a considerable decrease in the expression of the angiogenic marker vascular endothelial growth factor in muscles.",False,"Is the triple 'Methylprednisolone related to chronic obstructive pulmonary disease' supported by the sentence: 'Additionally, compared with albendazole, it resulted in a significant reduction in adult worm and total larval counts; moreover, it caused a decrease in the number of larvae deposited in muscles, with a highly significant decrease in the inflammatory cell infiltrate around the larvae and a considerable decrease in the expression of the angiogenic marker vascular endothelial growth factor in muscles.'?","No, methylprednisolone is not directly linked to chronic obstructive pulmonary disease (COPD) in this sentence. Methylprednisolone is an anti-inflammatory drug often used in conditions associated with inflammation, while COPD is a progressive lung disease characterized by difficulty in breathing due to narrowed airways, not directly involving worms, larvae, or vascular endothelial growth factor expression in muscles, as mentioned in this sentence." -18938435,Methylprednisolone related to graft versus host disease,11,"Quarterly albendazole during childhood was associated with reduced incidence of clinical malaria (HR 0.85 (95% CI 0.73-0.98), p = 0.03).",False,"Is the triple 'Methylprednisolone related to graft versus host disease' supported by the sentence: 'Quarterly albendazole during childhood was associated with reduced incidence of clinical malaria (HR 0.85 (95% CI 0.73-0.98), p = 0.03).'?","No, this sentence does not provide any support for a relationship between Methylprednisolone and graft versus host disease (GvHD). This sentence is discussing the association between quarterly albendazole during childhood and reduced incidence of clinical malaria, not Methylprednisolone or GvHD." -17333962,Methylprednisolone related to Inflammation,12,CONCLUSIONS: Mebendazole and albendazole showed reduced efficacy against Ascaris lumbricoides and hookworm infections at the recommended doses.,False,Is the triple 'Methylprednisolone related to Inflammation' supported by the sentence: 'CONCLUSIONS: Mebendazole and albendazole showed reduced efficacy against Ascaris lumbricoides and hookworm infections at the recommended doses.'?,"No, this sentence does not provide evidence for a relationship between Methylprednisolone and inflammation. The sentence discusses the efficacy of two drugs, Mebendazole and albendazole, against certain parasitic infections, but it does not mention Methylprednisolone or inflammation. Methylprednisolone is a corticosteroid often used to reduce inflammation, but there is no connection made in this sentence." -17288506,Methylprednisolone related to autoimmune thrombocytopenic purpura,13,Evaluation of effectiveness of diethylcarbamazine/albendazole combination in reduction of Wuchereria bancrofti infection using multiple infection parameters.,False,Is the triple 'Methylprednisolone related to autoimmune thrombocytopenic purpura' supported by the sentence: 'Evaluation of effectiveness of diethylcarbamazine/albendazole combination in reduction of Wuchereria bancrofti infection using multiple infection parameters.'?,"No, this statement does not provide any support for a relationship between Methylprednisolone and autoimmune thrombocytopenic purpura. The sentence discusses the evaluation of a drug combination for reducing Wuchereria bancrofti infection, which is unrelated to Methylprednisolone and autoimmune thrombocytopenic purpura." -15936572,Methylprednisolone related to endocrine exophthalmos,14,"Our evaluation suggests that although additional studies are needed to determine optimal treatment regimens for intestinal parasites, especially among young children and pregnant women, a five-day course of pre-departure albendazole was effective in reducing helminthic infection in treated refugees.",False,"Is the triple 'Methylprednisolone related to endocrine exophthalmos' supported by the sentence: 'Our evaluation suggests that although additional studies are needed to determine optimal treatment regimens for intestinal parasites, especially among young children and pregnant women, a five-day course of pre-departure albendazole was effective in reducing helminthic infection in treated refugees.'?","No, this sentence does not provide any indirect support for the statement that Methylprednisolone is related to endocrine exophthalmos. The sentence discusses the effectiveness of pre-departure albendazole in reducing helminthic infection in refugees, which is not relevant to Methylprednisolone or endocrine exophthalmos." -15072844,Methylprednisolone related to Edema,15,"The purpose of this study was the development and validation of an LC-MS-MS method for simultaneous analysis of ibuprofen (IBP), 2-hydroxyibuprofen (2-OH-IBP) enantiomers, and carboxyibuprofen (COOH-IBP) stereoisomers in fungi culture medium, to investigate the ability of some endophytic fungi to biotransform the chiral drug IBP into its metabolites.",False,"Is the triple 'Methylprednisolone related to Edema' supported by the sentence: 'The purpose of this study was the development and validation of an LC-MS-MS method for simultaneous analysis of ibuprofen (IBP), 2-hydroxyibuprofen (2-OH-IBP) enantiomers, and carboxyibuprofen (COOH-IBP) stereoisomers in fungi culture medium, to investigate the ability of some endophytic fungi to biotransform the chiral drug IBP into its metabolites.'?","No, the sentence does not provide any information about Methylprednisolone, let alone any indirect relationship between Methylprednisolone and Edema. The sentence discusses the development and validation of an LC-MS-MS method for analyzing ibuprofen (IBP) and its metabolites in fungi culture medium, suggesting an investigation into how endophytic fungi can transform IBP into its metabolites, but it does not mention Methylprednisolone or any conditions like Edema." -14876749,Methylprednisolone related to osteoarthritis,16,"AIMS: To carry out a randomized clinical trial to compare the effect of palmitoylethanolamide (PEA) versus ibuprofen, a nonsteroidal anti-inflammatory drug (NSAID), for pain relief in temporomandibular joint (TMJ) osteoarthritis or arthralgia.",False,"Is the triple 'Methylprednisolone related to osteoarthritis' supported by the sentence: 'AIMS: To carry out a randomized clinical trial to compare the effect of palmitoylethanolamide (PEA) versus ibuprofen, a nonsteroidal anti-inflammatory drug (NSAID), for pain relief in temporomandibular joint (TMJ) osteoarthritis or arthralgia.'?","No, this sentence does not provide any evidence for a relationship between Methylprednisolone and osteoarthritis. The sentence compares the effect of palmitoylethanolamide (PEA) versus ibuprofen, an NSAID, for pain relief in temporomandibular joint (TMJ) osteoarthritis or arthralgia. Methylprednisolone is not mentioned in this sentence, so there is no indirect support for any relationship between Methylprednisolone and osteoarthritis." -14399082,Methylprednisolone related to aplastic anemia,17,"We investigated the analgesic efficacy of single doses of ibuprofen, tramadol and pregabalin in menthol-evoked cold pain in a randomized, placebo-controlled four-way cross-over study in 20 healthy volunteers.",False,"Is the triple 'Methylprednisolone related to aplastic anemia' supported by the sentence: 'We investigated the analgesic efficacy of single doses of ibuprofen, tramadol and pregabalin in menthol-evoked cold pain in a randomized, placebo-controlled four-way cross-over study in 20 healthy volunteers.'?","No, this sentence does not provide any support for the claim that Methylprednisolone is related to aplastic anemia, directly or indirectly. The sentence discusses a study on the analgesic efficacy of ibuprofen, tramadol, and pregabalin in menthol-evoked cold pain, but it does not mention Methylprednisolone or aplastic anemia at all." -14398237,Methylprednisolone related to IgA glomerulonephritis,18,Double blind study on emorfazone and ibuprofen in dental pain and inflammation.,False,Is the triple 'Methylprednisolone related to IgA glomerulonephritis' supported by the sentence: 'Double blind study on emorfazone and ibuprofen in dental pain and inflammation.'?,"No, this sentence does not provide any support for a relationship between Methylprednisolone and IgA glomerulonephritis. The sentence discusses a double-blind study on emorfazone and ibuprofen in dental pain and inflammation, which is unrelated to Methylprednisolone and IgA glomerulonephritis." -14278238,"Methylprednisolone related to dermatitis, atopic",19,Glucosamine sulfate compared to ibuprofen in osteoarthritis of the knee.,False,"Is the triple 'Methylprednisolone related to dermatitis, atopic' supported by the sentence: 'Glucosamine sulfate compared to ibuprofen in osteoarthritis of the knee.'?","No, there is no direct or indirect relationship between Methylprednisolone, which is a steroid medication, and atopic dermatitis, an allergic skin condition, in the provided sentence. The sentence discusses Glucosamine sulfate compared to ibuprofen in osteoarthritis of the knee, which is not relevant to the triple mentioned in your question." -14166179,Methylprednisolone related to cardiac arrest,20,INTRODUCTION: The anti-inflammatory and anticoagulant effects of ibuprofen and heparin may enhance skin perfusion in cutaneous scald burns.,False,Is the triple 'Methylprednisolone related to cardiac arrest' supported by the sentence: 'INTRODUCTION: The anti-inflammatory and anticoagulant effects of ibuprofen and heparin may enhance skin perfusion in cutaneous scald burns.'?,"No, there is no direct or indirect support in this sentence for a relationship between Methylprednisolone and cardiac arrest. The sentence only mentions the anti-inflammatory effects of ibuprofen and the anticoagulant effects of heparin in relation to cutaneous scald burns, but it does not mention Methylprednisolone, nor does it imply any risk of cardiac arrest associated with these medications." -12755316,Methylprednisolone related to plasma cell myeloma,21,"CONCLUSIONS: Ibuprofen-induced patent ductus arteriosus closure improved pulmonary mechanics, decreased total lung water, increased epithelial sodium channel expression, and decreased the detrimental effects of preterm birth on alveolarization.",False,"Is the triple 'Methylprednisolone related to plasma cell myeloma' supported by the sentence: 'CONCLUSIONS: Ibuprofen-induced patent ductus arteriosus closure improved pulmonary mechanics, decreased total lung water, increased epithelial sodium channel expression, and decreased the detrimental effects of preterm birth on alveolarization.'?","No, this sentence does not provide any information about Methylprednisolone, its relation to Plasma Cell Myeloma, Ibuprofen, patent ductus arteriosus, pulmonary mechanics, total lung water, epithelial sodium channel expression, preterm birth, or alveolarization. Therefore, it does not support any indirect relationship between Methylprednisolone and Plasma Cell Myeloma." -12183687,Methylprednisolone related to acute lymphoblastic leukemia,22,Protein profile in neuroblastoma cells incubated with S- and R-enantiomers of ibuprofen by iTRAQ-coupled 2-D LC-MS/MS analysis: possible action of induced proteins on Alzheimer's disease.,False,Is the triple 'Methylprednisolone related to acute lymphoblastic leukemia' supported by the sentence: 'Protein profile in neuroblastoma cells incubated with S- and R-enantiomers of ibuprofen by iTRAQ-coupled 2-D LC-MS/MS analysis: possible action of induced proteins on Alzheimer's disease.'?,"No, this sentence does not provide any support for a relationship between Methylprednisolone and acute lymphoblastic leukemia, directly or indirectly. The sentence discusses protein profile changes in neuroblastoma cells incubated with S- and R-enantiomers of ibuprofen, and potential implications for Alzheimer's disease, which is unrelated to Methylprednisolone and acute lymphoblastic leukemia." -11720471,Methylprednisolone related to systemic lupus erythematosus,23,Protective effect of glucosamine against ibuprofen-induced peptic ulcer in rats.,False,Is the triple 'Methylprednisolone related to systemic lupus erythematosus' supported by the sentence: 'Protective effect of glucosamine against ibuprofen-induced peptic ulcer in rats.'?,"No, this sentence does not provide any support for a relationship between Methylprednisolone and systemic lupus erythematosus, indirectly or otherwise. The sentence discusses the protective effect of glucosamine against ibuprofen-induced peptic ulcer in rats, which is unrelated to Methylprednisolone or systemic lupus erythematosus." -10812685,Methylprednisolone related to immunoglobulin a vasculitis,24,Ibuprofen-induced fever in Sjogren's syndrome.,False,Is the triple 'Methylprednisolone related to immunoglobulin a vasculitis' supported by the sentence: 'Ibuprofen-induced fever in Sjogren's syndrome.'?,"No, this sentence does not provide any direct or indirect support for a relationship between Methylprednisolone and immunoglobulin a vasculitis based on the mentioned Ibuprofen-induced fever in Sjogren's syndrome. Methylprednisolone is a corticosteroid used primarily for its anti-inflammatory effects, while Immunoglobulin A vasculitis (IgAV), formerly known as Henoch-Schönlein purpura, is a small-vessel vasculitis characterized by IgA1-dominant immune deposits. Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) which can cause fever as an adverse effect, particularly in patients with Sjogren's syndrome, an autoimmune disorder characterized by dryness in various mucous membranes. None of these entities have any direct connection in this sentence, making it irrelevant in establishing any link between Methylprednisolone and IgAV." -10763477,Methylprednisolone related to ulcerative colitis,25,There have been no prior definite cases reported of ibuprofen-induced pancreatitis.,False,Is the triple 'Methylprednisolone related to ulcerative colitis' supported by the sentence: 'There have been no prior definite cases reported of ibuprofen-induced pancreatitis.'?,"No, this sentence does not provide any information about methylprednisolone, nor does it provide any indirect evidence about its relationship to ulcerative colitis. Methylprednisolone is a corticosteroid, while ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID). The sentence is discussing ibuprofen-induced pancreatitis, not methylprednisolone or ulcerative colitis." -10558884,Methylprednisolone related to lupus nephritis,26,"RESULTS: None of the studies established any of the COX-2 inhibitors as clearly better than ibuprofen, the current gold standard for the treatment of surgically induced dental pain.",False,"Is the triple 'Methylprednisolone related to lupus nephritis' supported by the sentence: 'RESULTS: None of the studies established any of the COX-2 inhibitors as clearly better than ibuprofen, the current gold standard for the treatment of surgically induced dental pain.'?","No, this statement does not provide any support for a relationship between Methylprednisolone and lupus nephritis. The sentence discusses the effectiveness of COX-2 inhibitors, including ibuprofen, in treating surgically induced dental pain, but it does not mention Methylprednisolone or lupus nephritis." -10130342,Methylprednisolone related to adult acute respiratory distress syndrome,27,Noncardiogenic pulmonary edema due to ibuprofen.,False,Is the triple 'Methylprednisolone related to adult acute respiratory distress syndrome' supported by the sentence: 'Noncardiogenic pulmonary edema due to ibuprofen.'?,"No, this sentence does not provide support for a relationship between Methylprednisolone and adult acute respiratory distress syndrome (ARDS). The sentence only mentions ibuprofen as a cause for noncardiogenic pulmonary edema, which is different from ARDS. Methylprednisolone is a corticosteroid often used in the treatment of ARDS, but it is not directly mentioned in this sentence." -9229208,Methylprednisolone related to vestibular neuronitis,28,"In a double-blind cross-over study on 22 healthy subjects the analgesic efficacies of the antipyretic analgesic drugs ibuprofen, dipyrone and paracetamol were tested against placebo using a model of experimentally induced pain.",False,"Is the triple 'Methylprednisolone related to vestibular neuronitis' supported by the sentence: 'In a double-blind cross-over study on 22 healthy subjects the analgesic efficacies of the antipyretic analgesic drugs ibuprofen, dipyrone and paracetamol were tested against placebo using a model of experimentally induced pain.'?","No, this sentence does not provide any support for a relationship between Methylprednisolone and vestibular neuronitis. The sentence discusses a study on the analgesic efficacies of ibuprofen, dipyrone, paracetamol, and placebo in healthy subjects, but it does not mention Methylprednisolone or vestibular neuronitis." -9003326,Methylprednisolone related to systemic sclerosis,29,Unaltered ibuprofen-induced faecal blood loss upon coadministration of moclobemide.,False,Is the triple 'Methylprednisolone related to systemic sclerosis' supported by the sentence: 'Unaltered ibuprofen-induced faecal blood loss upon coadministration of moclobemide.'?,"No, this sentence does not provide any information about Methylprednisolone, let alone its relationship to systemic sclerosis. Moclobemide is an MAO inhibitor, while ibuprofen is a non-steroidal anti-inflammatory drug (NSAID). The sentence discusses their combined effect on faecal blood loss, but it does not mention Methylprednisolone, which is a corticosteroid, nor does it provide any indirect inference about its potential relationship with systemic sclerosis." -8447481,Methylprednisolone related to rheumatoid arthritis,30,The C5a antagonist (1 or 3 mg/kg/day) and/or ibuprofen (30 mg/kg/day) were administered orally on a daily basis either before or after arthritis induction.,False,Is the triple 'Methylprednisolone related to rheumatoid arthritis' supported by the sentence: 'The C5a antagonist (1 or 3 mg/kg/day) and/or ibuprofen (30 mg/kg/day) were administered orally on a daily basis either before or after arthritis induction.'?,"No, the sentence does not provide support for a relationship between Methylprednisolone and rheumatoid arthritis. The sentence mentions the use of a C5a antagonist and ibuprofen in the context of arthritis induction, but there is no mention of Methylprednisolone." -8282330,Methylprednisolone related to spinal cord injury,31,RESULTS: Ketoprofen 50 mg t.d.s. suppressed prostaglandin synthesis to a significantly greater extent than ibuprofen and caused significantly more gastroduodenal injury.,False,Is the triple 'Methylprednisolone related to spinal cord injury' supported by the sentence: 'RESULTS: Ketoprofen 50 mg t.d.s. suppressed prostaglandin synthesis to a significantly greater extent than ibuprofen and caused significantly more gastroduodenal injury.'?,"No, this sentence does not provide any indirect support for a relationship between Methylprednisolone and spinal cord injury. The sentence compares the effects of Ketoprofen and Ibuprofen on prostaglandin synthesis and gastroduodenal injury, making no mention of Methylprednisolone or spinal cord injury." -7944646,Methylprednisolone related to myasthenia gravis,32,The duration of action of sustained-release ibuprofen ('Brufen Retard') was investigated in a 14-day double-blind study involving 14 osteoarthritis and 10 rheumatoid arthritis patients.,False,Is the triple 'Methylprednisolone related to myasthenia gravis' supported by the sentence: 'The duration of action of sustained-release ibuprofen ('Brufen Retard') was investigated in a 14-day double-blind study involving 14 osteoarthritis and 10 rheumatoid arthritis patients.'?,"No, this sentence does not provide any support for a relationship between Methylprednisolone and Myasthenia Gravis. The sentence discusses a study on sustained-release ibuprofen (Brufen Retard) in osteoarthritis and rheumatoid arthritis patients, but it does not mention Methylprednisolone or Myasthenia Gravis." -7668599,Methylprednisolone related to multiple sclerosis,33,This study attempts to investigate the effect of ibuprofen on reducing eye pain and migraine headaches caused by trochleitis.,False,Is the triple 'Methylprednisolone related to multiple sclerosis' supported by the sentence: 'This study attempts to investigate the effect of ibuprofen on reducing eye pain and migraine headaches caused by trochleitis.'?,"No, this sentence does not provide any indirect support for a relationship between Methylprednisolone and multiple sclerosis. The sentence discusses a study on ibuprofen's effect on eye pain and migraine headaches caused by trochleitis, which is an inflammation of a part of the eye. Methylprednisolone is a corticosteroid often used in treating various inflammatory and autoimmune conditions, including multiple sclerosis, but there is no mention of it in this sentence." -7443745,Methylprednisolone related to asthma,34,"Ibuprofen suppresses the production of various pro-inflammatory cytokines that are implicated in the ""cytokine storm"" and subsequent ARDS in COVID-19 disease.",False,"Is the triple 'Methylprednisolone related to asthma' supported by the sentence: 'Ibuprofen suppresses the production of various pro-inflammatory cytokines that are implicated in the ""cytokine storm"" and subsequent ARDS in COVID-19 disease.'?","No, this statement does not provide any direct or indirect evidence supporting a relationship between Methylprednisolone and asthma. The sentence provided discusses Ibuprofen, its effect on pro-inflammatory cytokines, and its potential role in COVID-19 disease, but it does not mention Methylprednisolone or asthma." -24973247,Methylprednisolone causes lupus nephritis,35,"After adjusting for covariates, the risk of BPD was associated independently with ibuprofen exposure (odds ratios (OR) 2.296, 95% confidence interval (CI): 1.166-4.522, p = 0.016).",False,"Is the triple 'Methylprednisolone causes lupus nephritis' supported by the sentence: 'After adjusting for covariates, the risk of BPD was associated independently with ibuprofen exposure (odds ratios (OR) 2.296, 95% confidence interval (CI): 1.166-4.522, p = 0.016).'?","No, this sentence does not provide any support for the statement that Methylprednisolone causes lupus nephritis, indirectly or otherwise. The sentence discusses the association between ibuprofen exposure and BPD (Bronchopulmonary Dysplasia), not Methylprednisolone and lupus nephritis." -24161886,Methylprednisolone causes Edema,36,The opposite effect of ibuprofen on ethanol-induced cognitive impairment as measured by two lateralized functions is consistent with the reports in tissue and animal models that central nervous system effects of ethanol may be mediated at least in part by prostaglandins.,False,Is the triple 'Methylprednisolone causes Edema' supported by the sentence: 'The opposite effect of ibuprofen on ethanol-induced cognitive impairment as measured by two lateralized functions is consistent with the reports in tissue and animal models that central nervous system effects of ethanol may be mediated at least in part by prostaglandins.'?,"No, this sentence does not support the claim that Methylprednisolone causes edema. The sentence mentions Ibuprofen, Ethanol, prostaglandins, and cognitive impairment, but it does not mention Methylprednisolone or edema. Therefore, there is no direct or indirect support for the claim based on this sentence alone." -18534953,Methylprednisolone causes Inflammation,37,"On post-partum day five, she began complaining of headaches, initially responsive to ibuprofen but eventually worsened with no relief.",False,"Is the triple 'Methylprednisolone causes Inflammation' supported by the sentence: 'On post-partum day five, she began complaining of headaches, initially responsive to ibuprofen but eventually worsened with no relief.'?","No, this sentence does not support the claim that Methylprednisolone causes inflammation. The sentence describes a patient who developed headaches on post-partum day five, which were initially responsive to ibuprofen but later worsened without relief. This scenario is more indicative of a tension headache or migraine, not inflammation, as there is no mention of symptoms typically associated with inflammation, such as redness, swelling, warmth, or pain worsening with movement. Furthermore, Methylprednisolone is a corticosteroid commonly used to reduce inflammation, not cause it, making it even less likely to support the claim." -18260665,Methylprednisolone causes neoplasm,38,"Because ibuprofen protects from septic lung injury, we studied the effect of ibuprofen in oxidant lung injury from phosgene.",False,"Is the triple 'Methylprednisolone causes neoplasm' supported by the sentence: 'Because ibuprofen protects from septic lung injury, we studied the effect of ibuprofen in oxidant lung injury from phosgene.'?","No, this sentence does not provide indirect support for the statement ""Methylprednisolone causes neoplasm"". The sentence discusses the protective effects of ibuprofen in septic and oxidant lung injury, but it does not mention methylprednisolone or any related adverse effects such as neoplasm (cancer)." -17307095,Methylprednisolone causes pneumonia,39,The efficacy and tolerance of ibuprofen retard at a dose of 2 x 800 mg daily was investigated in an open multicenter study over a period of 3 weeks on 7931 out-patients with activated degenerative joint disease and/or extraarticular rheumatic symptoms.,False,Is the triple 'Methylprednisolone causes pneumonia' supported by the sentence: 'The efficacy and tolerance of ibuprofen retard at a dose of 2 x 800 mg daily was investigated in an open multicenter study over a period of 3 weeks on 7931 out-patients with activated degenerative joint disease and/or extraarticular rheumatic symptoms.'?,"No, this sentence does not provide any support for the statement ""Methylprednisolone causes pneumonia."" It discusses the efficacy and tolerance of ibuprofen in patients with joint disease and rheumatic symptoms, but it does not mention Methylprednisolone or pneumonia at all." -15906641,Methylprednisolone causes Pain,40,"Overall, we found no relation between regular aspirin use and cognitive decline, but long-term use of ibuprofen may be related to decreased rates of cognitive decline in older persons.",False,"Is the triple 'Methylprednisolone causes Pain' supported by the sentence: 'Overall, we found no relation between regular aspirin use and cognitive decline, but long-term use of ibuprofen may be related to decreased rates of cognitive decline in older persons.'?","No, this sentence does not support the statement that Methylprednisolone causes pain. This sentence discusses regular aspirin use, cognitive decline, and long-term use of ibuprofen, but it does not mention Methylprednisolone nor pain." -13166073,Methylprednisolone causes thrombocytopenia,41,"Subdiaphragmatic vagotomy or 7-nitroindazole reduced, icatibant, DALBK, IL-1ra, aminoguanidine and dipyrone abolished, while ibuprofen and celecoxib failed to affect Tsv-induced fever.",False,"Is the triple 'Methylprednisolone causes thrombocytopenia' supported by the sentence: 'Subdiaphragmatic vagotomy or 7-nitroindazole reduced, icatibant, DALBK, IL-1ra, aminoguanidine and dipyrone abolished, while ibuprofen and celecoxib failed to affect Tsv-induced fever.'?","No, this sentence does not provide indirect support for the statement that Methylprednisolone causes thrombocytopenia. The sentence discusses the effects of various substances on Tsv-induced fever, but it does not mention Methylprednisolone or thrombocytopenia." -12672767,Methylprednisolone causes drug-induced liver injury,42,Reduced incidence of gastroduodenal ulcers associated with lumiracoxib compared with ibuprofen in patients with rheumatoid arthritis.,False,Is the triple 'Methylprednisolone causes drug-induced liver injury' supported by the sentence: 'Reduced incidence of gastroduodenal ulcers associated with lumiracoxib compared with ibuprofen in patients with rheumatoid arthritis.'?,"No, this sentence does not provide any indirect support for the statement that Methylprednisolone causes drug-induced liver injury. The sentence discusses the reduced incidence of gastroduodenal ulcers associated with lumiracoxib compared to ibuprofen in patients with rheumatoid arthritis, but it does not mention Methylprednisolone or liver injury." -8525599,Methylprednisolone causes myopathy,43,It was also investigated whether the use of ibuprofen or paracetamol would influence the amount of surgical bleeding.,False,Is the triple 'Methylprednisolone causes myopathy' supported by the sentence: 'It was also investigated whether the use of ibuprofen or paracetamol would influence the amount of surgical bleeding.'?,"No, this statement does not provide any indirect support for the claim that Methylprednisolone causes myopathy. The use of ibuprofen or paracetamol influencing surgical bleeding is not related to Methylprednisolone causing myopathy." -27357949,Methylprednisolone affects neoplasm,44,"In a randomised, placebo-controlled, double-blind trial of prophylaxis with ibuprofen, the rate of patent ductus arteriosus associated with ibuprofen was 19% compared with 42% with placebo.",False,"Is the triple 'Methylprednisolone affects neoplasm' supported by the sentence: 'In a randomised, placebo-controlled, double-blind trial of prophylaxis with ibuprofen, the rate of patent ductus arteriosus associated with ibuprofen was 19% compared with 42% with placebo.'?","No, this sentence does not provide support for the statement that Methylprednisolone affects neoplasm, either directly or indirectly. The sentence describes a trial comparing ibuprofen to placebo in preventing patent ductus arteriosus, which is an abnormal connection between two major blood vessels leading from the heart in babies, not about Methylprednisolone or its effects on neoplasms (abnormal growths such as tumors)." -24420470,Methylprednisolone affects Inflammation,45,"The purpose of this study was to examine the effects of ibuprofen on delayed onset muscle soreness (DOMS), indirect markers of muscle damage and muscular performance.",False,"Is the triple 'Methylprednisolone affects Inflammation' supported by the sentence: 'The purpose of this study was to examine the effects of ibuprofen on delayed onset muscle soreness (DOMS), indirect markers of muscle damage and muscular performance.'?","No, this sentence does not indirectly support the claim that Methylprednisolone affects inflammation. The sentence discusses a study on ibuprofen, not Methylprednisolone, and its effects on delayed onset muscle soreness (DOMS), markers of muscle damage, and muscular performance. Therefore, it does not provide any evidence or implications about Methylprednisolone's impact on inflammation." -23472756,Methylprednisolone affects Inflammation,46,CONCLUSIONS: Pretreatment with ibuprofen before elective total hip surgery increases the perioperative blood loss significantly.,False,Is the triple 'Methylprednisolone affects Inflammation' supported by the sentence: 'CONCLUSIONS: Pretreatment with ibuprofen before elective total hip surgery increases the perioperative blood loss significantly.'?,"No, this sentence does not provide support for the statement that Methylprednisolone affects inflammation, directly or indirectly. The sentence concludes that pretreatment with ibuprofen before elective total hip surgery increases perioperative blood loss significantly, but it does not mention Methylprednisolone or inflammation." -20530617,Methylprednisolone affects systemic sclerosis,47,"The data suggest that nimesulide and ibuprofen, in addition to their anti-inflammatory and analgesic benefits, may also have a protective effect in osteoarthritis through the inhibition of apoptosis in chondrocytes.",False,"Is the triple 'Methylprednisolone affects systemic sclerosis' supported by the sentence: 'The data suggest that nimesulide and ibuprofen, in addition to their anti-inflammatory and analgesic benefits, may also have a protective effect in osteoarthritis through the inhibition of apoptosis in chondrocytes.'?","No, this sentence does not provide support for the idea that Methylprednisolone affects systemic sclerosis, directly or indirectly. The sentence discusses the potential protective effects of nimesulide and ibuprofen on osteoarthritis through inhibition of apoptosis in chondrocytes, but it does not mention Methylprednisolone or systemic sclerosis." -20254789,Methylprednisolone affects adult acute respiratory distress syndrome,48,Pretreatment with ibuprofen blocked the fever induced by RANTES.,False,Is the triple 'Methylprednisolone affects adult acute respiratory distress syndrome' supported by the sentence: 'Pretreatment with ibuprofen blocked the fever induced by RANTES.'?,"No, this sentence does not provide support for the claim that Methylprednisolone affects adult acute respiratory distress syndrome (ARDS). The sentence only mentions that ibuprofen blocked the fever induced by RANTES, which does not involve Methylprednisolone or ARDS." -17649050,Methylprednisolone affects optic nerve disorder,49,This study evaluated whether administration of the pharmacologically active S(+)-isomer of ibuprofen suppresses acute pain and plasma beta-endorphin levels in the oral surgery model of acute pain.,False,Is the triple 'Methylprednisolone affects optic nerve disorder' supported by the sentence: 'This study evaluated whether administration of the pharmacologically active S(+)-isomer of ibuprofen suppresses acute pain and plasma beta-endorphin levels in the oral surgery model of acute pain.'?,"No, this sentence does not provide any support for the idea that Methylprednisolone affects optic nerve disorder, either directly or indirectly. The sentence discusses a study evaluating whether administration of ibuprofen, specifically the S(+)-isomer, suppresses acute pain and plasma beta-endorphin levels in an oral surgery model of acute pain. There is no mention or implication of Methylprednisolone, its effects, or its relation to optic nerve disorders in this sentence." -16634377,Methylprednisolone affects myasthenia gravis,50,"On the other hand, in subgroup B, no improvement in flexibility or reduction in muscle soreness was found in patients who took ibuprofen.",False,"Is the triple 'Methylprednisolone affects myasthenia gravis' supported by the sentence: 'On the other hand, in subgroup B, no improvement in flexibility or reduction in muscle soreness was found in patients who took ibuprofen.'?","No, this sentence does not provide support for the idea that Methylprednisolone affects Myasthenia Gravis indirectly through Ibuprofen, because it refers to patients who took ibuprofen, not Methylprednisolone, and it discusses flexibility and muscle soreness, not Myasthenia Gravis." -16277488,Methylprednisolone affects neuromyelitis optica,51,"This is termed, Celery Seed Extract (CSE) and has been found to be at least as effective as aspirin, ibuprofen, and naproxen in suppressing arthritis in a model of polyarthritis.",False,"Is the triple 'Methylprednisolone affects neuromyelitis optica' supported by the sentence: 'This is termed, Celery Seed Extract (CSE) and has been found to be at least as effective as aspirin, ibuprofen, and naproxen in suppressing arthritis in a model of polyarthritis.'?","No, this sentence does not provide any indirect support for the statement ""Methylprednisolone affects neuromyelitis optica"". The sentence discusses the effectiveness of Celery Seed Extract (CSE) in suppressing arthritis in a polyarthritis model, but it does not mention Methylprednisolone, nor does it mention any condition related to neuromyelitis optica." -15906642,Methylprednisolone affects Pain,52,INTRODUCTION: Hospitalized patients are often unable to ingest or tolerate oral antipyretics and recently an aqueous formulation of intravenous (IV) ibuprofen was approved by the US-FDA for the reduction of fever in adults.,False,Is the triple 'Methylprednisolone affects Pain' supported by the sentence: 'INTRODUCTION: Hospitalized patients are often unable to ingest or tolerate oral antipyretics and recently an aqueous formulation of intravenous (IV) ibuprofen was approved by the US-FDA for the reduction of fever in adults.'?,"No, this sentence does not provide direct evidence to support the claim that Methylprednisolone affects pain, either directly or indirectly. This sentence discusses the use of intravenous ibuprofen for fever reduction in adults, but it does not mention Methylprednisolone, pain, or any indirect relationship between these elements." -15610554,Methylprednisolone affects rheumatoid arthritis,53,"OBJECTIVES: This study compared the analgesic effectiveness of acetaminophen-codeine with that of ibuprofen for children with acute traumatic extremity pain, with the hypothesis that the two medications would demonstrate equivalent reduction in pain scores in an emergency department (ED) setting.",False,"Is the triple 'Methylprednisolone affects rheumatoid arthritis' supported by the sentence: 'OBJECTIVES: This study compared the analgesic effectiveness of acetaminophen-codeine with that of ibuprofen for children with acute traumatic extremity pain, with the hypothesis that the two medications would demonstrate equivalent reduction in pain scores in an emergency department (ED) setting.'?","No, this sentence does not support the claim that Methylprednisolone affects rheumatoid arthritis, directly or indirectly. The sentence discusses a study comparing the analgesic effectiveness of acetaminophen-codeine with ibuprofen for children with acute traumatic extremity pain, but it does not mention Methylprednisolone or rheumatoid arthritis at all." -15186368,Methylprednisolone affects graft versus host disease,54,"Thus, the anti-inflammatory drug ibuprofen, which has been associated with reduced AD risk in human epidemiological studies, can significantly delay some forms of AD pathology, including amyloid deposition, when administered early in the disease course of a transgenic mouse model of AD.",False,"Is the triple 'Methylprednisolone affects graft versus host disease' supported by the sentence: 'Thus, the anti-inflammatory drug ibuprofen, which has been associated with reduced AD risk in human epidemiological studies, can significantly delay some forms of AD pathology, including amyloid deposition, when administered early in the disease course of a transgenic mouse model of AD.'?","No, this sentence does not provide indirect support for the statement that Methylprednisolone affects graft versus host disease. The sentence discusses the effects of ibuprofen on Alzheimer's disease (AD) in mouse models, while the original statement is about Methylprednisolone's potential impact on graft versus host disease. These two statements discuss different diseases and drugs, so they are not related." -14891106,Methylprednisolone affects kidney disorder,55,"The hypoxia, hypertension and increased prostanoids were prevented using ibuprofen.",False,"Is the triple 'Methylprednisolone affects kidney disorder' supported by the sentence: 'The hypoxia, hypertension and increased prostanoids were prevented using ibuprofen.'?","No, this sentence does not provide support for the claim that Methylprednisolone affects kidney disorders indirectly via hypoxia, hypertension, and increased prostanoids being prevented by ibuprofen. The sentence only mentions that ibuprofen prevents hypoxia, hypertension, and increased prostanoids, without any reference to Methylprednisolone or kidney disorders." -11819955,Methylprednisolone affects spinal cord injury,56,"The Effect of Ibuprofen Dosing Interval on Post-Tonsillectomy Outcomes in Children: A Quality Improvement Study.OBJECTIVE: In this Quality Improvement (QI project) it was hypothesized that an increase in dosing intervals for postoperative analgesia when alternating Ibuprofen and Acetaminophen would reduce post-tonsillectomy hemorrhage (PTH) rates for those undergoing tonsillectomies with or without adenoidectomy, while maintaining the standard of postoperative analgesia and reducing visits to the Emergency Room (ER) for reasons other than PTH.",False,"Is the triple 'Methylprednisolone affects spinal cord injury' supported by the sentence: 'The Effect of Ibuprofen Dosing Interval on Post-Tonsillectomy Outcomes in Children: A Quality Improvement Study.OBJECTIVE: In this Quality Improvement (QI project) it was hypothesized that an increase in dosing intervals for postoperative analgesia when alternating Ibuprofen and Acetaminophen would reduce post-tonsillectomy hemorrhage (PTH) rates for those undergoing tonsillectomies with or without adenoidectomy, while maintaining the standard of postoperative analgesia and reducing visits to the Emergency Room (ER) for reasons other than PTH.'?","No, this sentence does not provide any information about Methylprednisolone, so it cannot indirectly support the statement about Methylprednisolone affecting spinal cord injury. The sentence discusses a Quality Improvement project about postoperative analgesia in children undergoing tonsillectomies, specifically testing whether increasing dosing intervals for Ibuprofen can reduce post-tonsillectomy hemorrhage rates while maintaining postoperative analgesia and reducing Emergency Room visits for reasons other than PTH." -10845505,Methylprednisolone affects Pain,57,Studies show that ibuprofen demonstrates superior efficacy in fever reduction compared to acetaminophen.,False,Is the triple 'Methylprednisolone affects Pain' supported by the sentence: 'Studies show that ibuprofen demonstrates superior efficacy in fever reduction compared to acetaminophen.'?,"No, this statement does not provide any indirect support for the idea that Methylprednisolone affects pain. The sentence only compares the fever-reducing efficacy of ibuprofen and acetaminophen, it does not mention Methylprednisolone or pain at all." -10048898,Methylprednisolone affects ulcerative colitis,58,IV Ibuprofen for Prevention of Post-Ercp Pancreatitis in Children: A Randomized Placebo-Controlled Feasibility Study.,False,Is the triple 'Methylprednisolone affects ulcerative colitis' supported by the sentence: 'IV Ibuprofen for Prevention of Post-Ercp Pancreatitis in Children: A Randomized Placebo-Controlled Feasibility Study.'?,"No, this sentence does not provide any support for the statement that Methylprednisolone affects ulcerative colitis, directly or indirectly. Ibuprofen is mentioned in the title, but there is no connection made to Methylprednisolone, ulcerative colitis, or any related pathways in the sentence provided." -9646753,Methylprednisolone affects multiple sclerosis,59,Altitude Sickness Prevention with Ibuprofen Relative to Acetazolamide.,False,Is the triple 'Methylprednisolone affects multiple sclerosis' supported by the sentence: 'Altitude Sickness Prevention with Ibuprofen Relative to Acetazolamide.'?,"No, this sentence does not provide any support for the claim that Methylprednisolone affects multiple sclerosis, directly or indirectly. The sentence discusses altitude sickness prevention using Ibuprofen compared to Acetazolamide, which is not related to Methylprednisolone or multiple sclerosis." -9346353,Methylprednisolone affects chronic obstructive pulmonary disease,60,"In conclusion, prednisone, ibuprofen and betamethasone may prevent OA by suppressing the expression of IL-6 and IL-8, subsequently inactivating NF-kappaB and STAT3 pathways, and ultimately, leading to decreased levels of collagen I, MMP-1, and MMP-13.",False,"Is the triple 'Methylprednisolone affects chronic obstructive pulmonary disease' supported by the sentence: 'In conclusion, prednisone, ibuprofen and betamethasone may prevent OA by suppressing the expression of IL-6 and IL-8, subsequently inactivating NF-kappaB and STAT3 pathways, and ultimately, leading to decreased levels of collagen I, MMP-1, and MMP-13.'?","No, this sentence does not support the claim that Methylprednisolone, specifically, has an effect on chronic obstructive pulmonary disease (COPD). The sentence discusses the effects of prednisone, ibuprofen, and betamethasone on osteoarthritis (OA), not COPD, and it does not mention Methylprednisolone at all. These drugs have different mechanisms of action, even though they all have anti-inflammatory effects, so we cannot infer that what is true for one is true for another without specific evidence." -9107378,Methylprednisolone affects Edema,61,"This study aims to determine the therapeutic effects of ibuprofen, diphenhydramine and aluminum magnesium simethicone (AlMgS) syrup on reducing oral aphthous ulcer pain.",False,"Is the triple 'Methylprednisolone affects Edema' supported by the sentence: 'This study aims to determine the therapeutic effects of ibuprofen, diphenhydramine and aluminum magnesium simethicone (AlMgS) syrup on reducing oral aphthous ulcer pain.'?","No, this statement does not provide any direct or indirect support for the claim that Methylprednisolone affects edema (swelling). The sentence only mentions three different drugs (ibuprofen, diphenhydramine, and aluminum magnesium simethicone syrup) and their potential therapeutic effects on oral aphthous ulcer pain, without making any reference to Methylprednisolone, edema, or their relationships." -8596544,Methylprednisolone affects asthma,62,"CONCLUSIONS: Considering the results of the study, reflexology was superior to Ibuprofen on reducing dysmenorrhea and its treatment effect continued even after discontinuing the intervention in the third cycle.",False,"Is the triple 'Methylprednisolone affects asthma' supported by the sentence: 'CONCLUSIONS: Considering the results of the study, reflexology was superior to Ibuprofen on reducing dysmenorrhea and its treatment effect continued even after discontinuing the intervention in the third cycle.'?","No, this sentence does not provide any support for the claim that Methylprednisolone affects asthma, directly or indirectly. The sentence discusses the effects of reflexology and Ibuprofen on dysmenorrhea, which is unrelated to Methylprednisolone and asthma." -8330909,Methylprednisolone affects systemic lupus erythematosus,63,CONCLUSION: We conclude that pain therapy with an almost peripherally acting drug such as ibuprofen can reduce osteoporosis-associated chronic pain better than a centrally acting pain medication such as tramadol.,False,Is the triple 'Methylprednisolone affects systemic lupus erythematosus' supported by the sentence: 'CONCLUSION: We conclude that pain therapy with an almost peripherally acting drug such as ibuprofen can reduce osteoporosis-associated chronic pain better than a centrally acting pain medication such as tramadol.'?,"No, this sentence does not provide support for the statement ""Methylprednisolone affects systemic lupus erythematosus"". The sentence discusses the effectiveness of two different types of pain medication, ibuprofen and tramadol, in managing osteoporosis-associated chronic pain, but it does not mention Methylprednisolone or systemic lupus erythematosus at all." -19744632,Methylprednisolone disrupts Edema,64,The objective of this study was to determine whether pretreatment with ibuprofen would prevent the onset or decrease the severity of headache that occurs after ECT.,False,Is the triple 'Methylprednisolone disrupts Edema' supported by the sentence: 'The objective of this study was to determine whether pretreatment with ibuprofen would prevent the onset or decrease the severity of headache that occurs after ECT.'?,"No, this sentence does not provide indirect support for the statement “Methylprednisolone disrupts Edema”. The study mentioned in this sentence investigates whether pretreatment with ibuprofen can prevent or decrease the severity of headaches after Electroconvulsive Therapy (ECT). Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) which is different from Methylprednisolone, a corticosteroid, used primarily for its anti-inflammatory and immunosuppressive effects in treating various conditions such as allergies, skin disorders, and autoimmune diseases, not specifically for edema treatment." -18407557,Methylprednisolone disrupts thrombocytopenia,65,The results of this study reveal that intake of ibuprofen can decrease muscle soreness induced after eccentric exercise but cannot assist in restoring muscle function.,False,Is the triple 'Methylprednisolone disrupts thrombocytopenia' supported by the sentence: 'The results of this study reveal that intake of ibuprofen can decrease muscle soreness induced after eccentric exercise but cannot assist in restoring muscle function.'?,"No, this statement does not provide any indirect support for the idea that methylprednisolone disrupts thrombocytopenia. The sentence discusses the effects of ibuprofen on muscle soreness and function, not methylprednisolone or thrombocytopenia." -11106658,Methylprednisolone disrupts Pain,66,The objective of our study was to determine the role of ibuprofen in protecting neutropenic rats from cardiopulmonary injury due to endotoxemia.,False,Is the triple 'Methylprednisolone disrupts Pain' supported by the sentence: 'The objective of our study was to determine the role of ibuprofen in protecting neutropenic rats from cardiopulmonary injury due to endotoxemia.'?,"No, this statement does not provide any indirect support for the triple statement ""Methylprednisolone disrupts Pain"". The objective of this study is to determine the role of ibuprofen in protecting neutropenic rats from cardiopulmonary injury due to endotoxemia, which is unrelated to methylprednisolone or pain disruption." -8640603,Methylprednisolone disrupts Inflammation,67,"To determine if prophylactic etodolac would significantly reduce postendodontic pain, when compared with ibuprofen or placebo, 36 patients consented to single blind oral administration of either 400 mg of etodolac, 600 mg of ibuprofen, or a placebo, before conventional one-appointment root canal therapy.",False,"Is the triple 'Methylprednisolone disrupts Inflammation' supported by the sentence: 'To determine if prophylactic etodolac would significantly reduce postendodontic pain, when compared with ibuprofen or placebo, 36 patients consented to single blind oral administration of either 400 mg of etodolac, 600 mg of ibuprofen, or a placebo, before conventional one-appointment root canal therapy.'?","No, this statement does not provide any direct or indirect support for the triple ""Methylprednisolone disrupts Inflammation"". The sentence discusses a study on the effects of prophylactic etodolac, ibuprofen, and placebo on postendodontic pain, but it does not mention Methylprednisolone or inflammation." -23934495,Methylprednisolone prevents Cognitive impairment,68,UNLABELLED: The aim of our study was to evaluate whether the prophylactic use of ibuprofen would reduce the incidence of significant patent ductus arteriosus (PDA) and to confirm the effectiveness of ibuprofen as rescue treatment in closing PDA.,False,Is the triple 'Methylprednisolone prevents Cognitive impairment' supported by the sentence: 'UNLABELLED: The aim of our study was to evaluate whether the prophylactic use of ibuprofen would reduce the incidence of significant patent ductus arteriosus (PDA) and to confirm the effectiveness of ibuprofen as rescue treatment in closing PDA.'?,"No, this sentence does not support the claim that Methylprednisolone prevents cognitive impairment, even indirectly. The sentence discusses the use of ibuprofen for preventing and treating patent ductus arteriosus (PDA), which is a congenital heart defect in premature infants. It does not mention Methylprednisolone, cognitive impairment, or any related topics." -20014108,Methylprednisolone prevents rheumatoid arthritis,69,"Nonsteroidal anti-inflammatory drugs (NSAIDs) such as aspirin, indomethacin and ibuprofen are the most widely used drugs for pain, arthritis, cardiovascular diseases and, more recently, the prevention of colon cancer and Alzheimer disease.",False,"Is the triple 'Methylprednisolone prevents rheumatoid arthritis' supported by the sentence: 'Nonsteroidal anti-inflammatory drugs (NSAIDs) such as aspirin, indomethacin and ibuprofen are the most widely used drugs for pain, arthritis, cardiovascular diseases and, more recently, the prevention of colon cancer and Alzheimer disease.'?","No, this sentence does not provide any support for the claim that Methylprednisolone prevents rheumatoid arthritis, directly or indirectly. The sentence only mentions NSAIDs, which is a different class of drugs from Methylprednisolone, which is a corticosteroid." -18266414,Methylprednisolone prevents Abdominal pain,70,Aggravation of seizure-associated microvascular injuries by ibuprofen may involve multiple pathways.,False,Is the triple 'Methylprednisolone prevents Abdominal pain' supported by the sentence: 'Aggravation of seizure-associated microvascular injuries by ibuprofen may involve multiple pathways.'?,"No, this statement is not indirectly supported by the given sentence. The sentence discusses ibuprofen aggravating seizure-associated microvascular injuries through multiple pathways, but it does not mention methylprednisolone, abdominal pain, or any link between them." -14967074,Methylprednisolone prevents asthma,71,"Use of paracetamol, ibuprofen or aspirin in pregnancy and risk of cerebral palsy in the child.",False,"Is the triple 'Methylprednisolone prevents asthma' supported by the sentence: 'Use of paracetamol, ibuprofen or aspirin in pregnancy and risk of cerebral palsy in the child.'?","No, this sentence does not provide any indirect support for the statement ""Methylprednisolone prevents asthma."" The sentence discusses the use of pain relievers during pregnancy and their potential effects on the child, while the initial statement is about the use of a specific steroid in preventing asthma. The two statements address different subjects and do not have any implicit connection." -9744990,Methylprednisolone prevents ovarian hyperstimulation syndrome,72,"More than two cycles of ibuprofen was significantly associated with an increased risk for bronchopulmonary dysplasia (odds ratio [OR], 2.81; p = 0.03) and acute renal failure (OR, 3.81; p = 0.09).",False,"Is the triple 'Methylprednisolone prevents ovarian hyperstimulation syndrome' supported by the sentence: 'More than two cycles of ibuprofen was significantly associated with an increased risk for bronchopulmonary dysplasia (odds ratio [OR], 2.81; p = 0.03) and acute renal failure (OR, 3.81; p = 0.09).'?","No, this sentence does not provide any support for the statement that Methylprednisolone prevents ovarian hyperstimulation syndrome, directly or indirectly. The sentence discusses the association between repeated cycles of ibuprofen and increased risk for bronchopulmonary dysplasia and acute renal failure, but it does not mention Methylprednisolone, ovarian hyperstimulation syndrome, or any indirect link between these concepts." -8345063,Methylprednisolone prevents Pain,73,OBJECTIVE: Non-steroidal anti-inflammatory drugs such as ibuprofen have a protective role on risk of Alzheimer's disease (AD).,False,Is the triple 'Methylprednisolone prevents Pain' supported by the sentence: 'OBJECTIVE: Non-steroidal anti-inflammatory drugs such as ibuprofen have a protective role on risk of Alzheimer's disease (AD).'?,"No, the sentence does not support the claim that Methylprednisolone prevents pain indirectly. The statement only mentions non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen, but it does not mention Methylprednisolone, which is a corticosteroid, not an NSAID." -8291272,Methylprednisolone prevents graft versus host disease,74,"There seems to be a marked gradient of risk for acute kidney injury across agents, specifically for indomethacin, ibuprofen, and rofecoxib.",False,"Is the triple 'Methylprednisolone prevents graft versus host disease' supported by the sentence: 'There seems to be a marked gradient of risk for acute kidney injury across agents, specifically for indomethacin, ibuprofen, and rofecoxib.'?","No, this sentence does not support the statement that Methylprednisolone prevents graft versus host disease. The sentence discusses the risk gradient for acute kidney injury among different non-steroidal anti-inflammatory drugs (NSAIDs) such as indomethacin, ibuprofen, and rofecoxib, but it does not mention Methylprednisolone, which is a corticosteroid, not an NSAID. Graft vs host disease prevention would require medication that modulates immune response, like Methylprednisolone, but this sentence does not provide any evidence for its effectiveness in preventing graft vs host disease, directly or indirectly." -7980138,Methylprednisolone prevents spinal cord injury,75,"Significant heterogeneity was present for the NSAIDs; e.g., ibuprofen was associated with an increased overall fracture risk (OR = 2.09, 95% CI 2.00-2.18 for <20 DDD), while celecoxib was not (OR = 0.76, 95% CI 0.51-1.13 for <20 DDD, 2P < 0.01 for comparison).",False,"Is the triple 'Methylprednisolone prevents spinal cord injury' supported by the sentence: 'Significant heterogeneity was present for the NSAIDs; e.g., ibuprofen was associated with an increased overall fracture risk (OR = 2.09, 95% CI 2.00-2.18 for <20 DDD), while celecoxib was not (OR = 0.76, 95% CI 0.51-1.13 for <20 DDD, 2P < 0.01 for comparison).'?","No, this sentence does not provide support for the statement that Methylprednisolone prevents spinal cord injury, directly or indirectly. The sentence discusses the effects of NSAIDs (Nonsteroidal Anti-Inflammatory Drugs), specifically ibuprofen and celecoxib, on overall fracture risk, not spinal cord injury. Methylprednisolone is a corticosteroid, not an NSAID, so it is not even mentioned in this sentence. Therefore, it does not provide any indirect support for the statement about Methylprednisolone preventing spinal cord injury." -7414405,Methylprednisolone prevents Edema,76,One should be more critical about ivabradine and low-dose digoxin in diastolic heart failure.,False,Is the triple 'Methylprednisolone prevents Edema' supported by the sentence: 'One should be more critical about ivabradine and low-dose digoxin in diastolic heart failure.'?,"No, this statement does not provide indirect support for the claim that Methylprednisolone prevents edema. The sentence only mentions two medications, ivabradine and low-dose digoxin, in relation to diastolic heart failure, but it does not mention Methylprednisolone or edema at all. Therefore, there is no connection to be made between these two statements." -18106042,Methylprednisolone predisposes pneumonia,77,"Preclinical studies of ivabradine in animal models with induced AF demonstrated a reduction in HR, with no significant worsening of QT interval or mean arterial pressure.",False,"Is the triple 'Methylprednisolone predisposes pneumonia' supported by the sentence: 'Preclinical studies of ivabradine in animal models with induced AF demonstrated a reduction in HR, with no significant worsening of QT interval or mean arterial pressure.'?","No, this statement does not provide any evidence to support the claim that Methylprednisolone predisposes pneumonia. The sentence is about preclinical studies of ivabradine in animal models with atrial fibrillation (AF), which showed no significant worsening of QT interval or mean arterial pressure despite a reduction in heart rate (HR). This information is not related to Methylprednisolone or its potential to predispose pneumonia." -9645180,Methylprednisolone predisposes Inflammation,78,"In this review, we summarize the current knowledge of the HCN4 channel and ivabradine, including the function of HCN4 in cardiac pacemaking, the mechanism of action of If inhibition by ivabradine, and the pharmacological and clinical effects of ivabradine in cardiac diseases as HF, coronary artery disease, and atrial fibrillation.",False,"Is the triple 'Methylprednisolone predisposes Inflammation' supported by the sentence: 'In this review, we summarize the current knowledge of the HCN4 channel and ivabradine, including the function of HCN4 in cardiac pacemaking, the mechanism of action of If inhibition by ivabradine, and the pharmacological and clinical effects of ivabradine in cardiac diseases as HF, coronary artery disease, and atrial fibrillation.'?","No, this sentence does not support the triple statement ""Methylprednisolone predisposes Inflammation"". The sentence discusses HCN4 channels, ivabradine, and its pharmacological effects on certain cardiac diseases, but it does not mention Methylprednisolone or inflammation." -12905337,Cefotaxime related to Sepsis,79,Small studies have recently investigated the role of ivabradine in MS in sinus rhythm.,False,Is the triple 'Cefotaxime related to Sepsis' supported by the sentence: 'Small studies have recently investigated the role of ivabradine in MS in sinus rhythm.'?,"No, this sentence does not provide any support for the relationship between Cefotaxime and sepsis because it discusses ivabradine, multiple sclerosis (MS), and sinus rhythm, but not Cefotaxime or sepsis." -24475300,Cefotaxime affects bacterial infectious disease,80,The role of Ivabradine in Diastolic Heart Failure with preserved Ejection Fraction.,False,Is the triple 'Cefotaxime affects bacterial infectious disease' supported by the sentence: 'The role of Ivabradine in Diastolic Heart Failure with preserved Ejection Fraction.'?,"No, this sentence does not provide any support for the statement about Cefotaxime affecting bacterial infectious diseases because it discusses Ivabradine, which is used to treat heart failure, not an antibiotic like Cefotaxime or any bacterial infection." -23922029,Cefotaxime affects Sepsis,81,"Other large trials are also underway to assess the effects of ivabradine on heart failure, acute coronary syndromes, CAD, and other cardiovascular disorders.",False,"Is the triple 'Cefotaxime affects Sepsis' supported by the sentence: 'Other large trials are also underway to assess the effects of ivabradine on heart failure, acute coronary syndromes, CAD, and other cardiovascular disorders.'?","No, this statement does not provide support for the claim that Cefotaxime affects sepsis, because it discusses trials on ivabradine, not Cefotaxime, and its effects on heart failure, acute coronary syndromes, coronary artery disease, and other cardiovascular disorders, not sepsis." -18672205,Cefotaxime affects peritonitis,82,"Other large trials are also underway to assess the effects of ivabradine on heart failure, acute coronary syndromes, CAD, and other cardiovascular disorders.",False,"Is the triple 'Cefotaxime affects peritonitis' supported by the sentence: 'Other large trials are also underway to assess the effects of ivabradine on heart failure, acute coronary syndromes, CAD, and other cardiovascular disorders.'?","No, this sentence does not provide any support for the statement that Cefotaxime affects peritonitis, as it discusses clinical trials on ivabradine, not Cefotaxime, for various cardiovascular disorders, but not for peritonitis." -15853591,Cefotaxime prevents Sepsis,83,Effective suppression of atrial fibrillation by ivabradine: Novel target for an established drug?,False,Is the triple 'Cefotaxime prevents Sepsis' supported by the sentence: 'Effective suppression of atrial fibrillation by ivabradine: Novel target for an established drug?'?,"No, this statement is not indirectly supported by the sentence provided. The sentence discusses the effect of ivabradine on suppressing atrial fibrillation, which is unrelated to Cefotaxime preventing sepsis." -19081412,Ceftriaxone prevents bacterial infectious disease,84,[SIGNIFY study is a disappointment. Ivabradine cannot stop of the progression of coronary heart disease].,False,Is the triple 'Ceftriaxone prevents bacterial infectious disease' supported by the sentence: '[SIGNIFY study is a disappointment. Ivabradine cannot stop of the progression of coronary heart disease].'?,"No, this statement is not indirectly supported by the given sentence. The sentence mentions nothing about Ceftriaxone, bacterial infections, or their prevention, so it does not provide any evidence for this claim." -25827448,Gefarnate related to gastric ulcer,85,RESULTS: Heart rate reduction and prevention of postoperative AF or tachyarrhythmia with combined therapy was more effective than with metoprolol or ivabradine alone during the immediate postoperative management of cardiac surgery patients.,False,Is the triple 'Gefarnate related to gastric ulcer' supported by the sentence: 'RESULTS: Heart rate reduction and prevention of postoperative AF or tachyarrhythmia with combined therapy was more effective than with metoprolol or ivabradine alone during the immediate postoperative management of cardiac surgery patients.'?,"No, the sentence does not support any indirect relationship between Gefarnate and gastric ulcers. The sentence discusses the effectiveness of combined therapy in reducing heart rate and preventing atrial fibrillation (AF) or tachyarrhythmia in patients undergoing cardiac surgery, compared to metoprolol or ivabradine alone. It does not mention Gefarnate or any conditions related to gastric ulcers." -24296137,Gefarnate related to duodenal ulcer,86,"During exercise, ivabradine dose dependently and significantly reduced the exercise-induced tachycardia (-17, -21, and -32% at 0.25, 0.5, and 1 mg/kg, respectively, versus saline) without altering myocardial contractility nor mean ejection wall stress.",False,"Is the triple 'Gefarnate related to duodenal ulcer' supported by the sentence: 'During exercise, ivabradine dose dependently and significantly reduced the exercise-induced tachycardia (-17, -21, and -32% at 0.25, 0.5, and 1 mg/kg, respectively, versus saline) without altering myocardial contractility nor mean ejection wall stress.'?","No, this sentence does not provide any support for a relationship between Gefarnate and duodenal ulcers. The sentence discusses the effects of ivabradine on heart rate and cardiac function during exercise, but it does not mention Gefarnate or duodenal ulcers." -25993651,Gefarnate disrupts gastric ulcer,87,Recent trials reported that risk of atrial fibrillation (AF) is increased in patients using ivabradine compared with controls.,False,Is the triple 'Gefarnate disrupts gastric ulcer' supported by the sentence: 'Recent trials reported that risk of atrial fibrillation (AF) is increased in patients using ivabradine compared with controls.'?,"No, this statement does not indirectly support the claim that Gefarnate disrupts gastric ulcers. The sentence mentions a correlation between ivabradine usage and an increased risk of atrial fibrillation, but it does not mention anything about Gefarnate, gastric ulcers, or their relationship." -17758516,Neobiotic related to Inflammation,88,Randomized comparative study of cefixime versus cephalexin in acute bacterial exacerbations of chronic bronchitis.,False,Is the triple 'Neobiotic related to Inflammation' supported by the sentence: 'Randomized comparative study of cefixime versus cephalexin in acute bacterial exacerbations of chronic bronchitis.'?,"No, I would not say there is direct support for the triple relationship between neobiotic, inflammation, and cefixime versus cephalexin in acute bacterial exacerbations of chronic bronchitis based on this sentence alone. The sentence discusses a comparative study between two antibiotics, cefixime and cephalexin, in treating acute bacterial exacerbations of chronic bronchitis, but it does not explicitly mention neobiotics or inflammation. Neobiotics refer to new forms of antibiotics, but this sentence does not provide any information about new antibiotics, their relationship with inflammation, or how they might be compared in treating chronic bronchitis." -10690423,Neobiotic related to burn,89,Alterations of the pilQ gene in Neisseria gonorrhoeae are unlikely contributors to decreased susceptibility to ceftriaxone and cefixime in clinical gonococcal strains.,False,Is the triple 'Neobiotic related to burn' supported by the sentence: 'Alterations of the pilQ gene in Neisseria gonorrhoeae are unlikely contributors to decreased susceptibility to ceftriaxone and cefixime in clinical gonococcal strains.'?,"No, the sentence does not provide any support for a relationship between Neobiotic, burn, and Neisseria gonorrhoeae. The sentence is discussing alterations of the pilQ gene in Neisseria gonorrhoeae and their relationship to decreased susceptibility to certain antibiotics, ceftriaxone and cefixime, in clinical gonococcal strains. There is no mention or implication of Neobiotic or burn in this context." -20263460,Neobiotic affects neoplasm,90,"Because of the emergence of these bacteria, other antimicrobial agents, both old and new, have been advocated for treatment and prevention of otitis media; amoxicillin-clavulanate, cefuroxime axetil, and cefixime are the newer agents.",False,"Is the triple 'Neobiotic affects neoplasm' supported by the sentence: 'Because of the emergence of these bacteria, other antimicrobial agents, both old and new, have been advocated for treatment and prevention of otitis media; amoxicillin-clavulanate, cefuroxime axetil, and cefixime are the newer agents.'?","No, this sentence does not provide direct or indirect support for the statement ""Neobiotic affects neoplasm."" The sentence discusses antibiotics used for treating otitis media, but it does not mention any effect on neoplasms, which are abnormal growths that can become cancerous. Neoplasms and bacteria (including those causing otitis media) are different biological entities, so there is no implicit connection to be drawn from this sentence alone." -19744068,Neobiotic affects Inflammation,91,Experimental comparison of protective characteristics of enalapril and trimetazidine in diabetic nephropathy.,False,Is the triple 'Neobiotic affects Inflammation' supported by the sentence: 'Experimental comparison of protective characteristics of enalapril and trimetazidine in diabetic nephropathy.'?,"No, this sentence does not directly support the statement that neobiotics affect inflammation, as it discusses the protective characteristics of two specific drugs, enalapril and trimetazidine, in diabetic nephropathy, without explicitly mentioning neobiotics or inflammation." -24669492,Neobiotic disrupts bacterial infectious disease,92,This study aimed to investigate the role of TMZ in diabetic nephropathy (DN) and its potential mechanisms.,False,Is the triple 'Neobiotic disrupts bacterial infectious disease' supported by the sentence: 'This study aimed to investigate the role of TMZ in diabetic nephropathy (DN) and its potential mechanisms.'?,"No, this statement does not indirectly support the triple statement ""Neobiotic disrupts bacterial infectious disease"". The sentence provided is about a study investigating the role of TMZ (temozolomide) in diabetic nephropathy (DN) and its potential mechanisms, which is unrelated to neobiotics and their impact on bacterial infections." -17119153,Neobiotic disrupts neoplasm,93,Objective: This study investigates the effect of TMZ in sunitinib-induced cardiotoxicity in vivo and in vitro and molecular mechanisms.,False,Is the triple 'Neobiotic disrupts neoplasm' supported by the sentence: 'Objective: This study investigates the effect of TMZ in sunitinib-induced cardiotoxicity in vivo and in vitro and molecular mechanisms.'?,"No, this statement does not provide any direct or indirect support for the claim “Neobiotic disrupts neoplasm” (assuming Neobiotic is short for TMZ in this context). The sentence only mentions an investigation into the effect of TMZ (Temozolomide) on sunitinib-induced cardiotoxicity, which is not related to disrupting neoplasms (tumors)." -26428369,Neobiotic prevents bacterial infectious disease,94,The role of trimetazidine in cardiovascular disease: beyond an anti-anginal agent.,False,Is the triple 'Neobiotic prevents bacterial infectious disease' supported by the sentence: 'The role of trimetazidine in cardiovascular disease: beyond an anti-anginal agent.'?,"No, this sentence does not provide indirect support for the statement ""Neobiotic prevents bacterial infectious disease."" The sentence discusses the role of trimetazidine in cardiovascular disease, which is not directly related to neobiotics or bacterial infections." -25579460,BLINATUMOMAB related to Precursor B-Cell Lymphoblastic Leukemia-Lymphoma,95,"Trimetazidine, 2.5 mg/kg/day i.p. for 3 days before doxorubicin administration plus 2.5 mg/kg/day p.o. for 10 weeks, was unable to prevent the development of doxorubicin-induced long-term cardiotoxicity.",False,"Is the triple 'BLINATUMOMAB related to Precursor B-Cell Lymphoblastic Leukemia-Lymphoma' supported by the sentence: 'Trimetazidine, 2.5 mg/kg/day i.p. for 3 days before doxorubicin administration plus 2.5 mg/kg/day p.o. for 10 weeks, was unable to prevent the development of doxorubicin-induced long-term cardiotoxicity.'?","No, this sentence does not provide any support for a relationship between BLINATUMOMAB and Precursor B-Cell Lymphoblastic Leukemia-Lymphoma. The sentence is about the use of Trimetazidine to prevent doxorubicin-induced cardiotoxicity, not about BLINATUMOMAB or Precursor B-Cell Lymphoblastic Leukemia-Lymphoma." -22474123,BLINATUMOMAB related to hematopoietic and lymphoid system neoplasm,96,Ranolazine was more effective than lidocaine in terminating persistent AF and in preventing the induction of AF.,False,Is the triple 'BLINATUMOMAB related to hematopoietic and lymphoid system neoplasm' supported by the sentence: 'Ranolazine was more effective than lidocaine in terminating persistent AF and in preventing the induction of AF.'?,"No, this sentence does not provide any information about BLINATUMOMAB or its relationship to hematopoietic and lymphoid system neoplasm. The sentence discusses the effectiveness of two drugs, ranolazine and lidocaine, in managing atrial fibrillation (AF). Therefore, it does not support any indirect relationship between BLINATUMOMAB and hematopoietic and lymphoid system neoplasm." -21947892,BLINATUMOMAB related to acute lymphoblastic leukemia,97,Role of Ranolazine in cardiovascular disease and diabetes: Exploring beyond angina.,False,Is the triple 'BLINATUMOMAB related to acute lymphoblastic leukemia' supported by the sentence: 'Role of Ranolazine in cardiovascular disease and diabetes: Exploring beyond angina.'?,"No, this statement does not provide any evidence for a relationship between BLINATUMOMAB and acute lymphoblastic leukemia. The sentence discusses the role of Ranolazine in cardiovascular disease and diabetes, with no mention of BLINATUMOMAB or its potential relation to acute lymphoblastic leukemia." -27155094,Ciprofloxacin related to endophthalmitis,98,"Furthermore, the activated Akt/mTOR signaling pathway induced by AF was further activated by ranolazine.",False,"Is the triple 'Ciprofloxacin related to endophthalmitis' supported by the sentence: 'Furthermore, the activated Akt/mTOR signaling pathway induced by AF was further activated by ranolazine.'?","No, this sentence does not provide any support for a relationship between Ciprofloxacin and endophthalmitis. The sentence discusses the Akt/mTOR signaling pathway being activated by AF (atrial fibrillation) and ranolazine, but it does not mention Ciprofloxacin or endophthalmitis." -16836665,Ciprofloxacin related to Crohn disease,99,Recent evidence of beneficial effects of ranolazine (RAN) in type II diabetes motivates interest in the role of the late sodium current (INaL) in glucose-stimulated insulin secretion.,False,Is the triple 'Ciprofloxacin related to Crohn disease' supported by the sentence: 'Recent evidence of beneficial effects of ranolazine (RAN) in type II diabetes motivates interest in the role of the late sodium current (INaL) in glucose-stimulated insulin secretion.'?,"No, this sentence does not provide any support for a relationship between Ciprofloxacin, which is an antibiotic, and Crohn disease, which is an inflammatory bowel disease. The sentence discusses the potential role of ranolazine in type II diabetes, which is not directly related to Ciprofloxacin or Crohn disease." -19572117,Ciprofloxacin related to DNA Gyrase,100,Effect of ranolazine in preventing postoperative atrial fibrillation in patients undergoing coronary revascularization surgery.,False,Is the triple 'Ciprofloxacin related to DNA Gyrase' supported by the sentence: 'Effect of ranolazine in preventing postoperative atrial fibrillation in patients undergoing coronary revascularization surgery.'?,"No, this statement does not provide any direct or indirect support for the triple ""Ciprofloxacin is related to DNA Gyrase"". The statement discusses the effect of ranolazine in preventing postoperative atrial fibrillation in patients undergoing coronary revascularization surgery, which is unrelated to Ciprofloxacin and DNA Gyrase. Ciprofloxacin is an antibiotic, while DNA Gyrase is an enzyme involved in bacterial DNA replication, and ranolazine is a medication used for treating chronic angina, making any connection between these concepts highly unlikely." +24413653,Fenbendazole treats helminthiasis,1001,"This study investigated worm control practices by free-range egg farmers and the efficacy of the commercial anthelmintics levamisole (LEV), piperazine (PIP), flubendazole (FLBZ) and fenbendazole (FBZ) against gastrointestinal nematodes on two free-range layer farms in Australia.",True,"Is the triple 'Fenbendazole treats helminthiasis' supported by the sentence: 'This study investigated worm control practices by free-range egg farmers and the efficacy of the commercial anthelmintics levamisole (LEV), piperazine (PIP), flubendazole (FLBZ) and fenbendazole (FBZ) against gastrointestinal nematodes on two free-range layer farms in Australia.'?","Yes, the statement does provide indirect support for the claim that ""Fenbendazole treats helminthiasis"". Helminthiasis is a medical condition characterized by parasitic worm infestation, often in the gastrointestinal tract. The study in question examined the efficacy of various anthelmintics (deworming agents) against gastrointestinal nematodes on free-range layer farms in Australia. Fenbendazole (FBZ) was one such anthelmintic included in the investigation. + + Although the statement does not explicitly confirm that fenbendazole treats helminthiasis in all contexts, it does demonstrate that fenbendazole has been studied for its effectiveness against gastrointestinal nematodes in specific situations (free-range egg farming in Australia). The fact that fenbendazole was selected for investigation in such a study suggests that it is recognized within the scientific community as having potential therapeutic value for treating worm infestations in certain hosts. + + However, it is crucial to emphasize that evidence from one study does not automatically generalize to all contexts; further investigation may be required to establish" +9783282,Thiabendazole treats helminthiasis,1002,[The treatment of helminthiasis with thiabendazole].,True,Is the triple 'Thiabendazole treats helminthiasis' supported by the sentence: '[The treatment of helminthiasis with thiabendazole].'?,"Yes, the phrase ""Thiabendazole treats helminthiasis"" does receive indirect support from the statement: ""[The treatment of helminthiasis with thiabendazole]."" + + + + The statement ""[The treatment of helminthiasis with thiabendazole]"" implies that thiabendazole is being used as a means to treat helminthiasis. Therefore, it can be inferred that thiabendazole has some therapeutic effect on helminthiasis, which is what the phrase ""Thiabendazole treats helminthiasis"" conveys. + + + + However, it is important to note that indirect support does not equate to definitive proof. While the statement suggests that thiabendazole may be an effective treatment for helminthiasis, further investigation would be necessary to confirm its efficacy, safety profile, and optimal usage conditions. This might involve randomized controlled trials, meta-analyses, and other rigorous scientific studies. + + + + In conclusion, while the statement does provide some level of support for the claim that th" +22678969,Albendazole treats Infection,1003,The control of STH infections is based on preventive chemotherapy using either albendazole or mebendazole.,True,Is the triple 'Albendazole treats Infection' supported by the sentence: 'The control of STH infections is based on preventive chemotherapy using either albendazole or mebendazole.'?,"Yes, the phrase ""Albendazole treats Infection"" does receive indirect support from the statement: ""The control of STH infections is based on preventive chemotherapy using either albendazole or mebendazole."" + + The statement suggests that albendazole is one of the primary medications used in preventive chemotherapy for soil-transmitted helminth (STH) infections, which implies that it has therapeutic efficacy against these parasites. Therefore, it can be inferred that albendazole does treat infections caused by STH parasites. However, it is essential to note that this interpretation is based on an indirect inference, as the original statement does not explicitly mention that albendazole treats infections but rather focuses on its use in preventive chemotherapy programs." +10750815,Albendazole treats onchocerciasis,1004,"A double-blind clinical trial was conducted in Monagas State, Venezuela to assess the tolerance and efficacy of albendazole in the therapy of Onchocerca volvulus infection.",True,"Is the triple 'Albendazole treats onchocerciasis' supported by the sentence: 'A double-blind clinical trial was conducted in Monagas State, Venezuela to assess the tolerance and efficacy of albendazole in the therapy of Onchocerca volvulus infection.'?","Yes, the statement does provide indirect support for the claim that Albendazole treats onchocerciasis (also known as river blindness). The clinical trial being conducted in Monagas State, Venezuela aimed to assess both the tolerance (how well it is tolerated by patients) and efficacy (how effectively it works) of albendazole in treating Onchocerca volvulus infection, which is a parasitic infection that can lead to onchocerciasis if left untreated. + + While the statement does not explicitly confirm that albendazole treats onchocerciasis successfully, it does indicate that researchers have investigated its potential as a therapeutic option for Onchocerca volvulus infection. The fact that a clinical trial was undertaken suggests that there is some basis for considering albendazole as a potential treatment for onchocerciasis in medical research circles. + + However, it is important to note that further information would be required in order to fully evaluate the evidence provided by the statement. For example, knowledge about the outcomes of that clinical trial would be valuable in determining whether albendazole indeed is an effective treatment for onch" +10114050,Albendazole treats toxocariasis,1005,"The treatment of cutaneous larva migrans and Toxocara infection relies on antihelminthic agents such as thiabendazole, albendazole and ivermectin.",True,"Is the triple 'Albendazole treats toxocariasis' supported by the sentence: 'The treatment of cutaneous larva migrans and Toxocara infection relies on antihelminthic agents such as thiabendazole, albendazole and ivermectin.'?","Yes, the statement does provide indirect support for the phrase ""Albendazole treats toxocariasis."" The reason is that cutaneous larva migrans and Toxocara infection are two different clinical manifestations caused by parasitic worms (nematodes). Toxocara infection refers specifically to Toxocariasis which is caused by Toxocara canis or Toxocara cati larvae that infect humans. + + The statement mentions that antihelminthic agents such as albendazole can be used in treating these infections. This implies that albendazole has some therapeutic effect on nematode infections in humans including Toxocariasis (toxocara infection). Therefore, it can be inferred that albendazole treats toxocariasis based on this indirect support. However, it is important to note that direct clinical trials may be required for definitive evidence regarding albendazole's efficacy in treating Toxocariasis specifically." +9588560,Albendazole treats trichuriasis,1006,"Three randomized clinical studies were conducted in 2000 to evaluate the efficacy of nitazoxanide paediatric suspension compared to albendazole in the treatment of ascariasis and trichuriasis and praziquantel in the treatment of hymenolepiasis in children from Cajamarca, Peru.",True,"Is the triple 'Albendazole treats trichuriasis' supported by the sentence: 'Three randomized clinical studies were conducted in 2000 to evaluate the efficacy of nitazoxanide paediatric suspension compared to albendazole in the treatment of ascariasis and trichuriasis and praziquantel in the treatment of hymenolepiasis in children from Cajamarca, Peru.'?","Yes, the statement does provide indirect support for the claim that albendazole treats trichuriasis. The randomized clinical studies conducted in 2000 compared nitazoxanide paediatric suspension and albendazole in treating ascariasis and trichuriasis in children from Cajamarca, Peru. The fact that albendazole was included in these studies suggests that it is recognized as a potential treatment for trichuriasis in published research. However, it is essential to review these studies in detail to evaluate albendazole's efficacy in treating trichuriasis specifically, as they involved comparisons against other treatments as well (nitazoxanide paediatric suspension in this case). + + In summary, while these studies do not directly prove that albendazole treats trichuriasis, they do provide evidence that albendazole is considered an appropriate treatment option for trichuriasis in clinical trials, which indirectly supports its efficacy as a treatment for trichuriasis." +9492446,Albendazole treats filariasis,1007,"Today, the only way is the prophylactic control of Onchocerca vovulus infections and treating lymphatic filariosis with ivermectin, diethylcarbamacine, ivermectin/diethylcarbamazine. or ivermectin/albendazole combinations.",True,"Is the triple 'Albendazole treats filariasis' supported by the sentence: 'Today, the only way is the prophylactic control of Onchocerca vovulus infections and treating lymphatic filariosis with ivermectin, diethylcarbamacine, ivermectin/diethylcarbamazine. or ivermectin/albendazole combinations.'?","Yes, the statement does provide indirect support for the claim that Albendazole treats filariasis (lymphatic filariosis). The text clearly states that ivermectin/albendazole combinations are used in treating lymphatic filariosis, which is another name for filariasis caused by Wuchereria bancrofti. This indicates that albendazole is indeed utilized in treating filariasis when used in combination with ivermectin. However, it is essential to note that albendazole alone may not be sufficient for treating filariasis; it is typically used in combination therapy." +8712067,Albendazole treats helminthiasis,1008,The study population was assessed for helminthic infection and those found to be positive were randomly assigned to either an albendazole treatment group or a control group who received a placebo.,True,Is the triple 'Albendazole treats helminthiasis' supported by the sentence: 'The study population was assessed for helminthic infection and those found to be positive were randomly assigned to either an albendazole treatment group or a control group who received a placebo.'?,"Yes, the statement does provide indirect support for the phrase ""Albendazole treats helminthiasis"". This is because it indicates that participants diagnosed with helminthic infection were given Albendazole as part of a treatment group in a clinical study. The positive correlation between treatment with Albendazole and resolution of helminthic infection would provide evidence supporting the claim that Albendazole treats helminthiasis. However, it is important to note that direct support would require analysis of outcomes in the treatment group versus the control group, which is not explicitly stated in the original statement." +7789677,Albendazole treats strongyloidiasis,1009,"To determine the host factors involved in response to treatment, 46 patients with strongyloidiasis were treated with albendazole, followed-up for 1 year, and separated into two groups: cured and non-cured.",True,"Is the triple 'Albendazole treats strongyloidiasis' supported by the sentence: 'To determine the host factors involved in response to treatment, 46 patients with strongyloidiasis were treated with albendazole, followed-up for 1 year, and separated into two groups: cured and non-cured.'?","Yes, the statement does provide indirect support for the claim that Albendazole treats strongyloidiasis. The fact that 46 patients diagnosed with strongyloidiasis were treated with Albendazole indicates that it is being used as a treatment option for this condition. Furthermore, the follow-up period of one year suggests an attempt to evaluate the long-term effectiveness of the treatment, which is consistent with the aim of treating strongyloidiasis. However, it is important to note that while this study design allows for inference about the efficacy of Albendazole in treating strongyloidiasis, it does not definitively prove it because other factors like dosage, patient compliance, and potential confounding variables may influence treatment outcomes. Ideally, a randomized controlled trial would provide stronger evidence for the claim that Albendazole treats strongyloidiasis by comparing it against a placebo or another treatment in a more controlled setting." +7640018,Albendazole treats filarial elephantiasis,1010,The role of albendazole in programmes to eliminate lymphatic filariasis.,True,Is the triple 'Albendazole treats filarial elephantiasis' supported by the sentence: 'The role of albendazole in programmes to eliminate lymphatic filariasis.'?,"Yes, the statement ""The role of albendazole in programmes to eliminate lymphatic filariasis"" does provide indirect support for the phrase ""Albendazole treats filarial elephantiasis"". This is because albendazole is often used as part of mass drug administration (MDA) programs aimed at eliminating lymphatic filariasis (LF), which includes filarial elephantiasis as one of its clinical manifestations. + + However, it is important to note that while albendazole is effective in killing microfilariae (the larval stage) produced by adult worms in infected individuals, it does not directly treat filarial elephantiasis itself. The drug helps reduce transmission by decreasing microfilariae levels in communities where it is administered regularly through MDA programs. In turn, it can help alleviate symptoms in infected individuals by reducing worm burden over time. + + Nonetheless, filarial elephantiasis is typically caused by long-term infection and inflammation due to adult worms living in the lymphatic system. Direct treatment for filarial elephantiasis primarily involves surgical" +7620262,Albendazole treats Hookworm Infections,1011,On the basis of our results the single 400 mg dose of albendazole is the treatment of choice for hookworm infections in this region of Mali.,True,Is the triple 'Albendazole treats Hookworm Infections' supported by the sentence: 'On the basis of our results the single 400 mg dose of albendazole is the treatment of choice for hookworm infections in this region of Mali.'?,"Yes, the phrase ""Albendazole treats Hookworm Infections"" does receive indirect support from the statement: ""On the basis of our results the single 400 mg dose of albendazole is the treatment of choice for hookworm infections in this region of Mali."" + + The statement suggests that albendazole is an effective treatment for hookworm infections in a specific region of Mali. This implies that albendazole has some therapeutic effect on hookworm infections, providing indirect support for the claim that albendazole treats hookworm infections. However, it is important to note that the effectiveness of albendazole may vary depending on the severity of the infection, the individual's health status, and other factors. Therefore, while the statement supports the idea that albendazole can treat hookworm infections, it does not necessarily confirm that albendazole is always effective in all cases and contexts." +7226097,Albendazole treats cysticercosis,1012,The efficacy of albendazole (15 mg/kg/d for 1 week) was compared with praziquantel (100 mg/kg in three divided doses at 2-hour intervals) for therapy of parenchymal brain cysticercosis.,True,Is the triple 'Albendazole treats cysticercosis' supported by the sentence: 'The efficacy of albendazole (15 mg/kg/d for 1 week) was compared with praziquantel (100 mg/kg in three divided doses at 2-hour intervals) for therapy of parenchymal brain cysticercosis.'?,"Yes, the statement does provide indirect support for the claim that Albendazole treats cysticercosis. The study referenced compares the efficacy of Albendazole and Praziquantel in treating parenchymal brain cysticercosis, which is a manifestation of cysticercosis caused by Taenia solium larvae (cysticerci) in the brain parenchyma. By implication, if Albendazole is shown to be effective in treating parenchymal brain cysticercosis in comparison to another drug in this study, it suggests that Albendazole indeed has therapeutic value in treating cysticercosis. + + However, it is important to note that direct support for the claim would require more specific information about the efficacy and safety profile of Albendazole in treating cysticercosis in comparison to no treatment or placebo. Additionally, further details on dosage regimens and potential side effects would be necessary for making definitive conclusions about its therapeutic utility in treating cysticercosis." +25678577,Latamoxef treats bacterial infectious disease,1013,"Clinical efficacy and safety of a new oxacephem, moxalactam, in serious bacterial infections.",False,"Is the triple 'Latamoxef treats bacterial infectious disease' supported by the sentence: 'Clinical efficacy and safety of a new oxacephem, moxalactam, in serious bacterial infections.'?","No, the statement ""Clinical efficacy and safety of a new oxacephem, moxalactam, in serious bacterial infections"" does not provide direct support for the phrase ""Latamoxef treats bacterial infectious disease"". + + Although both Latamoxef and Moxalactam belong to the oxacephem class of antibiotics which are known for their effectiveness against bacterial infections, they are distinct compounds. The clinical trial result mentioned supports Moxalactam but does not provide any evidence for Latamoxef specifically treating bacterial infectious disease. + + However, it should be noted that since they belong to the same class, they share similar mechanisms of action; thus, one could infer that if moxalactam is effective against bacterial infections, then other oxacephems like latamoxef might also be effective. But such an inference would still not constitute direct evidence for Latamoxef's efficacy against bacterial infections." +26824955,Ibuprofen treats spondylosis,1014,A comparison of the short-term effects of ibuprofen and diclofenac in spondylosis.,False,Is the triple 'Ibuprofen treats spondylosis' supported by the sentence: 'A comparison of the short-term effects of ibuprofen and diclofenac in spondylosis.'?,"No, the statement ""A comparison of the short-term effects of ibuprofen and diclofenac in spondylosis"" does not provide direct support for the claim that ""Ibuprofen treats spondylosis."" The statement only mentions a comparison between ibuprofen and diclofenac in terms of their short-term effects on spondylosis; it does not confirm that ibuprofen is an effective treatment for spondylosis. Indirect support may be possible if ibuprofen demonstrates superior short-term effects compared to diclofenac in treating spondylosis; however, further investigation would be required for more definitive evidence." +25670779,Ibuprofen treats sunburn,1015,"The data suggest that ibuprofen is more effective than placebo for the relief of symptoms associated with UV-B-induced inflammation after high dose UV-B phototherapy for psoriasis, but the drug has limited usefulness in the treatment of sunburn reaction from these same doses.",False,"Is the triple 'Ibuprofen treats sunburn' supported by the sentence: 'The data suggest that ibuprofen is more effective than placebo for the relief of symptoms associated with UV-B-induced inflammation after high dose UV-B phototherapy for psoriasis, but the drug has limited usefulness in the treatment of sunburn reaction from these same doses.'?","No, the statement does not provide indirect support for the phrase ""Ibuprofen treats sunburn."" The study referenced in the statement investigates ibuprofen's effectiveness in relieving symptoms associated with UV-B-induced inflammation after high dose UV-B phototherapy for psoriasis. Although ibuprofen has demonstrated efficacy in treating symptoms related to UV-B-induced inflammation in psoriasis patients undergoing phototherapy, it does not necessarily imply that ibuprofen is an effective treatment for sunburn reactions resulting from UV-B exposure in non-psoriasis patients. + + The study specifically mentions that ibuprofen has limited usefulness in treating sunburn reactions from high dose UV-B phototherapy in psoriasis patients. This finding suggests that ibuprofen may not be as effective for treating sunburn as other treatments specifically designed for addressing sunburn symptoms. + + In summary, while ibuprofen has demonstrated some benefits for treating symptoms associated with UV-B-induced inflammation in psoriasis patients undergoing phototherapy, it does not provide indirect support for the claim that ibuprofen treats sun" +25518118,Ibuprofen treats Fractured ankle,1016,"Huoxue Huayu Recipe combined with ibuprofen can reduce inflammatory factors levels in patients with ankle fracture, improve isokinetic muscle strength and ankle function, and accelerate the recovery of patients.",True,"Is the triple 'Ibuprofen treats Fractured ankle' supported by the sentence: 'Huoxue Huayu Recipe combined with ibuprofen can reduce inflammatory factors levels in patients with ankle fracture, improve isokinetic muscle strength and ankle function, and accelerate the recovery of patients.'?","Yes, indirectly it does lend some support. The statement suggests that using ibuprofen in conjunction with a traditional Chinese medicine recipe (Huoxue Huayu Recipe) for patients with ankle fractures leads to reduced inflammatory factors levels, improved isokinetic muscle strength, enhanced ankle function, and faster recovery. While the statement does not explicitly claim that ibuprofen alone treats fractured ankles, it does imply that ibuprofen contributes positively to the healing process when used as part of a treatment regimen for ankle fractures. + + + However, it is crucial to note that correlation does not imply causation; therefore, we cannot definitively conclude that ibuprofen alone treats ankle fractures based solely on this information. Further studies specifically investigating ibuprofen as monotherapy for ankle fractures would be required for stronger support for that claim." +25321029,Ibuprofen treats bronchopulmonary dysplasia,1017,"Treatment of newborn rat pups with ibuprofen reduced pulmonary vessel density in the developing lung, but also attenuated experimental BPD by reducing lung inflammation, alveolar enlargement, alveolar septum thickness and small arteriolar wall thickening.",True,"Is the triple 'Ibuprofen treats bronchopulmonary dysplasia' supported by the sentence: 'Treatment of newborn rat pups with ibuprofen reduced pulmonary vessel density in the developing lung, but also attenuated experimental BPD by reducing lung inflammation, alveolar enlargement, alveolar septum thickness and small arteriolar wall thickening.'?","Yes, indirect support can be inferred from the statement provided. Bronchopulmonary dysplasia (BPD) is characterized by chronic lung inflammation, alveolar enlargement, thickened alveolar septa, and small arteriolar wall thickening in newborns, particularly those born prematurely. The statement mentions that ibuprofen treatment in newborn rat pups led to reduced pulmonary vessel density, lung inflammation, alveolar enlargement, alveolar septum thickness, and small arteriolar wall thickening. By addressing these key features of BPD, ibuprofen may potentially alleviate symptoms associated with bronchopulmonary dysplasia. However, it is important to note that further investigation is required to establish a direct cause-and-effect relationship between ibuprofen use and improved BPD outcomes in humans, as animal studies may not fully capture all aspects of human disease pathophysiology." +22125431,Ibuprofen treats preeclampsia,1018,Introduction: The comparison of ibuprofen with acetaminophen for blood pressure (BP) in preeclampsia remains controversial.,False,Is the triple 'Ibuprofen treats preeclampsia' supported by the sentence: 'Introduction: The comparison of ibuprofen with acetaminophen for blood pressure (BP) in preeclampsia remains controversial.'?,"No, the statement does not provide indirect support for the phrase ""Ibuprofen treats preeclampsia."" The statement introduces a controversy surrounding the comparison of ibuprofen with acetaminophen for blood pressure in preeclampsia patients. However, it does not mention or imply that ibuprofen is an effective treatment for preeclampsia itself. It is essential to differentiate between addressing symptoms (blood pressure) and treating the condition (preeclampsia)." +21268743,Ibuprofen treats glioma,1019,"Taken together, our findings reveal that ibuprofen could induce ferroptosis of glioblastoma cells via downregulation of Nrf2 signaling pathway and is a potential drug for glioma treatment.",True,"Is the triple 'Ibuprofen treats glioma' supported by the sentence: 'Taken together, our findings reveal that ibuprofen could induce ferroptosis of glioblastoma cells via downregulation of Nrf2 signaling pathway and is a potential drug for glioma treatment.'?","Yes, the statement does provide indirect support for the phrase ""Ibuprofen treats glioma."" The statement suggests that ibuprofen can induce ferroptosis in glioblastoma cells (a type of glioma) by downregulating the Nrf2 signaling pathway. This implies that ibuprofen could potentially be used as a treatment for glioma, as it appears to have an effect on these cancerous cells. However, it is important to note that this is based on experimental findings in a specific context, and further research would be needed to confirm these results and evaluate the safety and efficacy of ibuprofen as a treatment for glioma in humans." +20821983,Ibuprofen treats common cold,1020,Ibuprofen (IBU) and phenylephrine hydrochloride (PE) were commonly used for common cold due to their different effects in relieving fever and the main symptoms such as nasal congestion and high sinus pressure.,False,Is the triple 'Ibuprofen treats common cold' supported by the sentence: 'Ibuprofen (IBU) and phenylephrine hydrochloride (PE) were commonly used for common cold due to their different effects in relieving fever and the main symptoms such as nasal congestion and high sinus pressure.'?,"No, the statement does not provide direct or indirect support for the phrase ""Ibuprofen treats common cold."" The statement mentions that Ibuprofen (IBU) is used for common cold symptoms such as fever reduction, but it does not imply that Ibuprofen treats the common cold itself. To claim that Ibuprofen treats the common cold, one would need evidence showing that Ibuprofen affects the underlying cause of the common cold (typically viral infections) rather than merely alleviating specific symptoms." +20285347,Ibuprofen treats periodontitis,1021,"Therefore, the objective of this study was to investigate the local delivery of the NSAIDs model drug ibuprofen to treat periodontitis using different types of gel formulations (hydrogel, oleogel, and bigel).",True,"Is the triple 'Ibuprofen treats periodontitis' supported by the sentence: 'Therefore, the objective of this study was to investigate the local delivery of the NSAIDs model drug ibuprofen to treat periodontitis using different types of gel formulations (hydrogel, oleogel, and bigel).'?","Yes, the statement does provide indirect support for the phrase ""Ibuprofen treats periodontitis"". The objective of the study explicitly mentions investigating the local delivery of ibuprofen as a treatment for periodontitis using various gel formulations (hydrogel, oleogel, and bigel). This implies that ibuprofen is being considered as a potential therapeutic agent for treating periodontitis in this study. However, it is important to note that direct support would require actual experimental results demonstrating ibuprofen's effectiveness in treating periodontitis, rather than simply stating its use as a model drug in an investigation." +19270581,Ibuprofen treats bone fracture,1022,Does the Use of Ibuprofen in Children with Extremity Fractures Increase their Risk for Bone Healing Complications?,False,Is the triple 'Ibuprofen treats bone fracture' supported by the sentence: 'Does the Use of Ibuprofen in Children with Extremity Fractures Increase their Risk for Bone Healing Complications?'?,"No, the statement ""Does the Use of Ibuprofen in Children with Extremity Fractures Increase their Risk for Bone Healing Complications?"" does not provide indirect support for the phrase ""Ibuprofen treats bone fracture."" In fact, it suggests quite the opposite. By asking if ibuprofen use increases the risk for bone healing complications, it implies that ibuprofen may have an effect on bone healing, which could be interpreted negatively in terms of treatment efficacy. However, it does not explicitly state that ibuprofen treats bone fractures, nor does it provide any evidence for such a claim. + + To provide indirect support for ""Ibuprofen treats bone fracture,"" one might point to studies showing that ibuprofen reduces inflammation and pain in fracture patients, thereby potentially improving their comfort and mobility during healing. But even then, ""treats"" is a strong word that implies a causative relationship between ibuprofen use and improved bone healing outcomes, which would require direct empirical evidence that is currently lacking in the provided statement." +17621968,Ibuprofen treats Cognitive impairment,1023,"Finally, anti-inflammatory drug ibuprofen ameliorated the peripheral surgical wounding-induced cognitive impairment in 18 month-old mice.",False,"Is the triple 'Ibuprofen treats Cognitive impairment' supported by the sentence: 'Finally, anti-inflammatory drug ibuprofen ameliorated the peripheral surgical wounding-induced cognitive impairment in 18 month-old mice.'?","No, the statement does not provide direct support for the claim that ibuprofen treats cognitive impairment in humans. The study was conducted on 18-month-old mice, which may not translate directly to humans, particularly given that cognitive impairment in mice may not be equivalent to cognitive impairment in humans. Additionally, an amelioration of surgical wounding-induced cognitive impairment is not equivalent to treating cognitive impairment caused by other factors. Therefore, while this study may suggest potential therapeutic avenues for further investigation, it does not provide definitive evidence that ibuprofen is an effective treatment for cognitive impairment in humans." +17292168,Ibuprofen treats Chronic pain,1024,"In the last several years, several topical NSAIDs including either diclofenac ibuprofen or salicylates for chronic pain have been approved in the United States while similar drugs have been available in Europe for years.",True,"Is the triple 'Ibuprofen treats Chronic pain' supported by the sentence: 'In the last several years, several topical NSAIDs including either diclofenac ibuprofen or salicylates for chronic pain have been approved in the United States while similar drugs have been available in Europe for years.'?","Yes, the statement does provide indirect support for the phrase ""Ibuprofen treats Chronic pain"". The given statement implies that topical NSAIDs such as diclofenac ibuprofen have been approved in the United States for treating chronic pain, suggesting that ibuprofen is an effective treatment for chronic pain. However, it is important to note that while this statement supports the efficacy of ibuprofen for treating chronic pain, it does not necessarily support the specific claim ""Ibuprofen treats Chronic pain"" without qualifications regarding dosage forms (topical vs oral), route of administration, side effects, etc. Therefore, further investigation would be required for more direct support of that particular phrasing." +15258520,Ibuprofen treats cardiovascular disorder,1025,Patent ductus arteriosus (PDA) is the most common cardiovascular abnormality of the preterm infant usually treated with ibuprofen (IBU).,False,Is the triple 'Ibuprofen treats cardiovascular disorder' supported by the sentence: 'Patent ductus arteriosus (PDA) is the most common cardiovascular abnormality of the preterm infant usually treated with ibuprofen (IBU).'?,"No, the statement ""Ibuprofen treats cardiovascular disorder"" does not receive direct support from ""Patent ductus arteriosus (PDA) is the most common cardiovascular abnormality of the preterm infant usually treated with ibuprofen (IBU)."" + + + + The reason for my answer is that while it is true that ibuprofen is used in treating PDA (a cardiovascular abnormality), it does not necessarily mean that ibuprofen treats cardiovascular disorders in general. PDA is a specific condition that occurs in preterm infants due to incomplete closure of certain blood vessels after birth. Ibuprofen is used in managing PDA because it helps promote constriction of these blood vessels; however, its efficacy is limited to PDA cases and does not imply that ibuprofen is effective in treating other cardiovascular disorders. + + + + It is essential not to overgeneralize the therapeutic application of ibuprofen based on its use in treating PDA alone since cardiovascular disorders encompass various conditions affecting heart function and blood vessels requiring distinct treatment approaches. Consequently, it" +13826476,"Ibuprofen treats osteoarthritis, spine",1026,"In an open three-center pilot study, 17 patients suffering from chronic persistent pain syndrome, due to osteoarthritis of the hip and knee or spondylarthrosis, were treated orally with 1800-2400 mg Ibuprofen per day for 3 weeks.",True,"Is the triple 'Ibuprofen treats osteoarthritis, spine' supported by the sentence: 'In an open three-center pilot study, 17 patients suffering from chronic persistent pain syndrome, due to osteoarthritis of the hip and knee or spondylarthrosis, were treated orally with 1800-2400 mg Ibuprofen per day for 3 weeks.'?","Yes, indirectly it does lend support. The statement mentions that patients suffering from chronic persistent pain syndrome due to osteoarthritis of the hip and knee or spondylarthrosis were treated with Ibuprofen for three weeks. The fact that they were treated implies that Ibuprofen was used as a therapeutic agent for these conditions, which includes osteoarthritis of the spine (spondylarthrosis). However, it is important to note that this is an open pilot study involving only 17 patients, which is not a large enough sample size to make definitive conclusions about the efficacy of Ibuprofen for treating osteoarthritis in the spine based on this study alone." +13722152,Ibuprofen treats Neck pain,1027,"The patient presented with a 6-month history of neck pain with radiation into the shoulder and arm on the left side, which was relieved by ibuprofen.",True,"Is the triple 'Ibuprofen treats Neck pain' supported by the sentence: 'The patient presented with a 6-month history of neck pain with radiation into the shoulder and arm on the left side, which was relieved by ibuprofen.'?","Yes, the statement does provide indirect support for the phrase ""Ibuprofen treats Neck pain"". The patient's relief from neck pain upon taking ibuprofen suggests that ibuprofen has therapeutic effects on neck pain. However, it is important to note that this is an observational finding in one patient and does not constitute definitive proof due to lack of control, randomization, and potential for placebo effect. Further studies would be needed to confirm these observations and establish causality." +11790277,Ibuprofen treats hypertensive disorder,1028,"Treatment with nonselective anti-inflammatory drugs ibuprofen, indomethacin, or salicylic acid did not show any effect on angiotensin II-induced superoxide production, hypertension, or cardiac hypertrophy.",False,"Is the triple 'Ibuprofen treats hypertensive disorder' supported by the sentence: 'Treatment with nonselective anti-inflammatory drugs ibuprofen, indomethacin, or salicylic acid did not show any effect on angiotensin II-induced superoxide production, hypertension, or cardiac hypertrophy.'?","No, the statement does not provide indirect support for the claim that ""Ibuprofen treats hypertensive disorder."" In fact, it suggests the opposite: ibuprofen has no significant effect on hypertension (high blood pressure) in this specific study context involving angiotensin II-induced hypertension and cardiac hypertrophy. Therefore, one cannot infer that ibuprofen can treat hypertensive disorders based on these results alone. It is essential to consider that individual studies may have limitations in terms of their scope and applicability; thus, further evidence from other studies may be required for more definitive conclusions regarding ibuprofen's potential therapeutic effects on hypertension." +11536369,Ibuprofen treats seasonal allergic rhinitis,1029,Addition of ibuprofen to pseudoephedrine and chlorpheniramine in the treatment of seasonal allergic rhinitis.,True,Is the triple 'Ibuprofen treats seasonal allergic rhinitis' supported by the sentence: 'Addition of ibuprofen to pseudoephedrine and chlorpheniramine in the treatment of seasonal allergic rhinitis.'?,"Yes, the statement does provide indirect support for the claim that ibuprofen treats seasonal allergic rhinitis (SAR). The addition of ibuprofen to other medications like pseudoephedrine and chlorpheniramine in treating SAR implies that ibuprofen has some therapeutic effect on SAR symptoms, thus lending support to its use as a treatment for SAR. However, it is important to note that the claim is not directly supported by this statement since it does not explicitly state that ibuprofen alone treats SAR; it only implies its efficacy as an additive treatment component." +11381904,Ibuprofen treats Premature birth,1030,This should be considered to assess pharmacokinetic-pharmacodynamic relationships of ibuprofen in premature neonates and subsequently to understand and refine the use of ibuprofen in managing PDA either as a prophylactic or curative treatment.,False,Is the triple 'Ibuprofen treats Premature birth' supported by the sentence: 'This should be considered to assess pharmacokinetic-pharmacodynamic relationships of ibuprofen in premature neonates and subsequently to understand and refine the use of ibuprofen in managing PDA either as a prophylactic or curative treatment.'?,"No, the statement does not provide direct support for the claim that ""Ibuprofen treats Premature birth."" The statement discusses analyzing pharmacokinetic-pharmacodynamic relationships of ibuprofen in premature neonates and refining its use in managing Patent Ductus Arteriosus (PDA). While PDA is common in premature infants, treating PDA is not equivalent to treating premature birth itself. The statement focuses on understanding how ibuprofen works in premature neonates in order to optimize its use for treating PDA, not on treating prematurity itself." +11239637,Ibuprofen treats Back pain,1031,"A 57-year-old woman believed that ibuprofen, prescribed for back pain, improved her idiopathic chronic cough that had been resistant to inhaled and oral corticosteroids.",False,"Is the triple 'Ibuprofen treats Back pain' supported by the sentence: 'A 57-year-old woman believed that ibuprofen, prescribed for back pain, improved her idiopathic chronic cough that had been resistant to inhaled and oral corticosteroids.'?","No, the statement does not provide direct or indirect support for the claim that ibuprofen treats back pain based on the information about a patient with chronic cough. The woman's belief about her improvement is anecdotal evidence that cannot be generalized to support ibuprofen's effectiveness in treating back pain since her medical condition is unrelated. The statement only highlights the potential side effect of ibuprofen on chronic cough in one individual; it does not demonstrate its therapeutic effect on back pain. A rigorous clinical study would be required to make such a claim about ibuprofen treating back pain." +10195210,Ibuprofen treats influenza,1032,"A multicenter, randomized, double-blind, double-dummy, placebo- and active-controlled, parallel-group comparison of diclofenac-K and ibuprofen for the treatment of adults with influenza-like symptoms.",False,"Is the triple 'Ibuprofen treats influenza' supported by the sentence: 'A multicenter, randomized, double-blind, double-dummy, placebo- and active-controlled, parallel-group comparison of diclofenac-K and ibuprofen for the treatment of adults with influenza-like symptoms.'?","No, the statement does not provide direct or indirect support for the phrase ""Ibuprofen treats influenza."" The study mentioned is comparing diclofenac-K and ibuprofen for treating adults with influenza-like symptoms; however, it does not prove that ibuprofen can treat influenza itself. The study design is also investigating whether diclofenac-K is superior to ibuprofen in treating these symptoms, which indicates that ibuprofen may alleviate symptoms but may not necessarily target the influenza virus itself. + + Additionally, influenza-like symptoms can be caused by various factors such as common colds or other respiratory infections, not solely influenza viruses. Therefore, it is crucial not to jump to conclusions about ibuprofen treating influenza based on this statement alone. Further investigation and evidence would be required for such support." +9950431,Ibuprofen treats rheumatic disorder,1033,"Eight preparations contained synthetic drugs (e.g. benzodiazepines and tricyclic antidepressants in sedative preparations, cyproheptadine in a remedy to gain bodyweight, ibuprofen and dipyrone in herbal capsules used to treat rheumatism).",True,"Is the triple 'Ibuprofen treats rheumatic disorder' supported by the sentence: 'Eight preparations contained synthetic drugs (e.g. benzodiazepines and tricyclic antidepressants in sedative preparations, cyproheptadine in a remedy to gain bodyweight, ibuprofen and dipyrone in herbal capsules used to treat rheumatism).'?","Yes, the statement does provide indirect support for the phrase ""Ibuprofen treats rheumatic disorder"". The key information here is that ibuprofen is listed as one of the synthetic drugs found in herbal capsules used to treat rheumatism. This implies that ibuprofen is being used as a therapeutic agent in the treatment of rheumatic disorders, which aligns with the claim that ibuprofen treats rheumatic disorder. However, it is important to note that this is indirect evidence and does not constitute definitive proof on its own. It would be strengthened by additional evidence from clinical trials or other robust studies demonstrating ibuprofen's efficacy in treating rheumatic disorders." +9913360,Ibuprofen treats Myalgia,1034,Preliminary comparison of bromelain and Ibuprofen for delayed onset muscle soreness management.,True,Is the triple 'Ibuprofen treats Myalgia' supported by the sentence: 'Preliminary comparison of bromelain and Ibuprofen for delayed onset muscle soreness management.'?,"Yes, the statement does provide indirect support for the phrase ""Ibuprofen treats Myalgia"". Myalgia refers to muscle pain or inflammation, which is what is being discussed in the statement ""Preliminary comparison of bromelain and Ibuprofen for delayed onset muscle soreness management."" Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) known for its ability to reduce pain and inflammation, which aligns with the treatment of myalgia. However, it is important to note that while this statement suggests Ibuprofen can help manage symptoms associated with myalgia, it does not definitively prove that Ibuprofen treats myalgia. Further research would be needed to make such a claim." +9550056,Ibuprofen treats Acute Pain,1035,"BACKGROUND: Rofecoxib is a selective cyclooxygenase-2 inhibitor indicated for the treatment of acute pain, with similar analgesic efficacy to ibuprofen and naproxen sodium.",True,"Is the triple 'Ibuprofen treats Acute Pain' supported by the sentence: 'BACKGROUND: Rofecoxib is a selective cyclooxygenase-2 inhibitor indicated for the treatment of acute pain, with similar analgesic efficacy to ibuprofen and naproxen sodium.'?","Yes, the statement does provide indirect support for the phrase ""Ibuprofen treats Acute Pain"". The background information indicates that Rofecoxib is used for treating acute pain and has similar analgesic efficacy to ibuprofen and naproxen sodium. Since ibuprofen is mentioned alongside Rofecoxib as having similar pain-relieving properties, it can be inferred that ibuprofen does indeed treat acute pain. However, it is important to note that this is an indirect inference based on comparative efficacy to another proven treatment rather than direct evidence of ibuprofen's effectiveness in treating acute pain." +9536612,Ibuprofen treats Low back pain,1036,CONCLUSION: Continuous low-level heat wrap therapy was superior to both acetaminophen and ibuprofen for treating low back pain.,True,Is the triple 'Ibuprofen treats Low back pain' supported by the sentence: 'CONCLUSION: Continuous low-level heat wrap therapy was superior to both acetaminophen and ibuprofen for treating low back pain.'?,"Yes, the statement does provide indirect support for the phrase ""Ibuprofen treats Low back pain"". The conclusion states that continuous low-level heat wrap therapy was superior to both acetaminophen and ibuprofen for treating low back pain. However, it does imply that ibuprofen has some efficacy in treating low back pain, albeit not as effective as heat wrap therapy or continuous low-level heat wrap therapy in this particular study. Therefore, while it doesn't strongly support the statement, it does provide some level of indirect evidence that ibuprofen can help alleviate low back pain." +9444914,Ibuprofen treats Arthralgia,1037,"To determine the effectiveness of oral glucosamine with ibuprofen for the relief of joint pain in osteoarthritis a mini-review (Griffiths, 2002) of double-blind randomized controlled trials comparing the two was undertaken.",False,"Is the triple 'Ibuprofen treats Arthralgia' supported by the sentence: 'To determine the effectiveness of oral glucosamine with ibuprofen for the relief of joint pain in osteoarthritis a mini-review (Griffiths, 2002) of double-blind randomized controlled trials comparing the two was undertaken.'?","No, the statement does not provide direct or indirect support for the claim that ""Ibuprofen treats Arthralgia"". The mini-review discussed in the statement compares oral glucosamine with ibuprofen for relief in joint pain specifically related to osteoarthritis. Arthralgia is defined as joint pain in general and is not limited to osteoarthritis. Therefore, even though ibuprofen might be effective in alleviating joint pain in osteoarthritis as suggested by the review, it does not necessarily mean that ibuprofen is effective in treating arthralgia in all cases." +9436288,Ibuprofen treats Alzheimer disease,1038,"In conclusion, NCX-2216 is more efficacious than ibuprofen or celecoxib in clearing Abeta deposits from the brains of Tg mice, implying potential benefit in the treatment of Alzheimer's dementia.",False,"Is the triple 'Ibuprofen treats Alzheimer disease' supported by the sentence: 'In conclusion, NCX-2216 is more efficacious than ibuprofen or celecoxib in clearing Abeta deposits from the brains of Tg mice, implying potential benefit in the treatment of Alzheimer's dementia.'?","No, the statement does not provide indirect support for the claim that ibuprofen treats Alzheimer disease. The conclusion drawn in the statement is about NCX-2216 being more efficacious than ibuprofen in clearing Abeta deposits from Tg mice brains. While it suggests that NCX-2216 could be beneficial in treating Alzheimer's dementia due to its effectiveness in removing beta-amyloid deposits (a known hallmark of Alzheimer's disease), it does not imply that ibuprofen has any direct therapeutic effect on Alzheimer disease. + + To further clarify, let us examine the components in question: + + - NCX-2216 is shown to be more effective than ibuprofen in clearing Abeta deposits in Tg mice brains. + - A potential benefit in treating Alzheimer's dementia is implied for NCX-2216 due to its efficacy in removing these deposits (which is associated with Alzheimer's disease progression). + - Ibuprofen does not receive any direct support for treating Alzheimer disease since" +9104501,Ibuprofen treats injury,1039,"Ibuprofen attenuates early lung injury in endotoxemic, neutropenic rats.",False,"Is the triple 'Ibuprofen treats injury' supported by the sentence: 'Ibuprofen attenuates early lung injury in endotoxemic, neutropenic rats.'?","No, the statement ""Ibuprofen attenuates early lung injury in endotoxemic, neutropenic rats"" does not provide direct support for the claim ""Ibuprofen treats injury."" While it is true that ibuprofen has been shown to have an attenuating effect on early lung injury in specific experimental conditions (endotoxemic, neutropenic rats), it does not necessarily mean that ibuprofen can be universally applied as an injury treatment in all contexts. + + + The study referenced in the statement is limited in scope as it focuses on lung injury in rats under specific conditions (endotoxemic, neutropenic). Additionally, attenuation is not equivalent to treatment; attenuation implies that ibuprofen can reduce severity but may not necessarily eliminate injury altogether nor promote healing as one would expect from a treatment. + + + Therefore, based on the provided evidence, we cannot infer that ibuprofen treats injury in general but only that it might have some potential benefits in specific circumstances such as early lung injury under endotoxemic and neutropenic conditions in rats. Further studies would be required to" +8748381,Ibuprofen treats Dysmenorrhea,1040,CONCLUSION: Continuous low-level topical heat therapy was as effective as ibuprofen for the treatment of dysmenorrhea.,True,Is the triple 'Ibuprofen treats Dysmenorrhea' supported by the sentence: 'CONCLUSION: Continuous low-level topical heat therapy was as effective as ibuprofen for the treatment of dysmenorrhea.'?,"Yes, the statement does provide indirect support for the claim that ibuprofen treats dysmenorrhea (menstrual pain). The conclusion of the study indicates that continuous low-level topical heat therapy is as effective as ibuprofen for treating dysmenorrhea. This implies that ibuprofen is indeed an effective treatment for dysmenorrhea, as it is compared favorably against another effective treatment in the study. + + However, it is important to note that while this study supports ibuprofen's effectiveness in treating dysmenorrhea relative to another treatment method, it does not provide direct evidence for ibuprofen being an absolute superior treatment compared to no treatment at all, nor does it compare ibuprofen against other pain relief medications for dysmenorrhea. Therefore, further studies would be required for more definitive conclusions regarding ibuprofen being the best treatment option for dysmenorrhea." +8698382,Ibuprofen treats Tension-type headache,1041,Is the combination of ibuprofen and caffeine effective for the treatment of a tension-type headache?,True,Is the triple 'Ibuprofen treats Tension-type headache' supported by the sentence: 'Is the combination of ibuprofen and caffeine effective for the treatment of a tension-type headache?'?,"Yes, there is indirect support for the phrase ""Ibuprofen treats Tension-type headache"" from the statement: ""Is the combination of ibuprofen and caffeine effective for the treatment of a tension-type headache?"" + + + + The reason for my decision is that ibuprofen is an active ingredient in the combination treatment mentioned in the second statement. Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) that has been proven effective in relieving pain from tension-type headaches by reducing inflammation and pain signaling in the brain (Tfelt-Hansen et al., 2000). + + + + Although the second statement refers to the combination of ibuprofen and caffeine as an effective treatment for tension-type headaches, it still implies that ibuprofen itself is an active component in managing such headaches. Therefore, it lends indirect support to the idea that ibuprofen can treat tension-type headaches. + + + + However, it is essential to acknowledge that combining ibuprofen with caffeine may provide" +8452594,Ibuprofen treats migraine disorder,1042,"Evaluation of a novel solubilized formulation of ibuprofen in the treatment of migraine headache: a randomized, double-blind, placebo-controlled, dose-ranging study.",True,"Is the triple 'Ibuprofen treats migraine disorder' supported by the sentence: 'Evaluation of a novel solubilized formulation of ibuprofen in the treatment of migraine headache: a randomized, double-blind, placebo-controlled, dose-ranging study.'?","Yes, the statement does provide indirect support for the phrase ""Ibuprofen treats migraine disorder"". The study mentioned is a randomized, double-blind, placebo-controlled, dose-ranging study - all of which indicate that it was conducted in a rigorous and unbiased manner. The fact that it specifically investigates the use of ibuprofen in treating migraine headaches suggests that there is some basis for believing that ibuprofen could be an effective treatment for migraines. However, it's important to note that this is indirect support. The study itself does not prove that ibuprofen treats migraine disorder, but it does suggest that further investigation into this potential treatment is warranted." +8420965,Ibuprofen treats Hemorrhage,1043,"A randomized trial measuring fecal blood loss after treatment with rofecoxib, ibuprofen, or placebo in healthy subjects.",False,"Is the triple 'Ibuprofen treats Hemorrhage' supported by the sentence: 'A randomized trial measuring fecal blood loss after treatment with rofecoxib, ibuprofen, or placebo in healthy subjects.'?","No, the statement ""Ibuprofen treats Hemorrhage"" does not receive direct or indirect support from the provided randomized trial statement. The study measures fecal blood loss after treatment with rofecoxib, ibuprofen, or placebo in healthy subjects but it does not provide evidence that ibuprofen treats hemorrhage in patients who experience it. The study is testing for differences in fecal blood loss between these groups in healthy individuals who may not have hemorrhage conditions at all. + + To support the claim that ""Ibuprofen treats Hemorrhage"", there would need to be specific evidence showing that ibuprofen reduces hemorrhage in patients suffering from it compared to either placebo or other treatments in controlled clinical trials designed explicitly for that purpose. A study measuring fecal blood loss in healthy individuals does not provide sufficient evidence for that claim due to differences in contexts, patient populations, and outcomes being evaluated." +8397426,Ibuprofen treats rheumatoid arthritis,1044,Ibuprofen or aspirin in rheumatoid arthritis therapy.,True,Is the triple 'Ibuprofen treats rheumatoid arthritis' supported by the sentence: 'Ibuprofen or aspirin in rheumatoid arthritis therapy.'?,"Yes, indirectly it does lend some support to the claim that ibuprofen treats rheumatoid arthritis. The statement ""Ibuprofen or aspirin in rheumatoid arthritis therapy"" suggests that both ibuprofen and aspirin are used in treating rheumatoid arthritis symptoms. This implies that ibuprofen has therapeutic effects on rheumatoid arthritis as it is recognized as an option for treatment within rheumatoid arthritis therapy. + + + + However, it is important to note that while ibuprofen may alleviate symptoms in rheumatoid arthritis patients, it does not necessarily mean it treats the underlying cause of the disease. Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) that helps reduce pain, inflammation, and fever in patients; thus its use is primarily aimed at managing symptoms rather than addressing the root cause of rheumatoid arthritis. + + + + In conclusion, although not definitive proof nor a direct statement about" +7887942,Ibuprofen treats osteoarthritis,1045,"DESIGN: Ginger extract was compared to placebo and Ibuprofen in patients with osteoarthritis of the hip or knee in a controlled, double blind, double dummy, cross-over study with a wash-out period of one week followed by three treatment periods in a randomized sequence, each of three weeks duration.",True,"Is the triple 'Ibuprofen treats osteoarthritis' supported by the sentence: 'DESIGN: Ginger extract was compared to placebo and Ibuprofen in patients with osteoarthritis of the hip or knee in a controlled, double blind, double dummy, cross-over study with a wash-out period of one week followed by three treatment periods in a randomized sequence, each of three weeks duration.'?","Yes, the statement does provide indirect support for the phrase ""Ibuprofen treats osteoarthritis"". The reason is that the study design described involves comparing ibuprofen to placebo in patients suffering from osteoarthritis of the hip or knee. By comparing an active treatment (ibuprofen) against an inactive treatment (placebo), researchers aim to determine whether ibuprofen has an effect on osteoarthritis symptoms beyond what could be attributed to chance or bias. + + However, it is important to note that while this study design can help establish whether ibuprofen is effective in treating osteoarthritis relative to placebo, it does not necessarily prove that ibuprofen treats osteoarthritis in an absolute sense. To make that claim, one would need additional evidence from other studies that investigate ibuprofen's efficacy in treating osteoarthritis compared to no treatment at all. + + Furthermore, it should be emphasized that even if ibuprofen is found to be effective in treating osteoarthritis symptoms, it does not mean that it is the best treatment option available for all patients. Other" +7852264,Ibuprofen treats Headache,1046,"Besides oxygen, acetazolamide, dexamethasone and especially inhibitors of prostaglandin synthesis such as ibuprofen and naproxen are approved for the treatment of HAH.",True,"Is the triple 'Ibuprofen treats Headache' supported by the sentence: 'Besides oxygen, acetazolamide, dexamethasone and especially inhibitors of prostaglandin synthesis such as ibuprofen and naproxen are approved for the treatment of HAH.'?","Yes, the statement does provide indirect support for the phrase ""Ibuprofen treats Headache"". The text mentions that ibuprofen is an approved treatment for HAH (High Altitude Headache), which is a type of headache. This implies that ibuprofen is indeed used in treating headaches, thus supporting the claim that ibuprofen treats headaches. However, it is important to note that headaches can have various causes and types, so the effectiveness of ibuprofen may vary depending on the specific headache condition." +7851777,Ibuprofen treats patent ductus arteriosus,1047,OBJECTIVE: To evaluate the effect of intravenous ibuprofen and indomethacin for treatment of patent ductus arteriosus (PDA) on mesenteric and renal blood flow velocity in preterm infants.,False,Is the triple 'Ibuprofen treats patent ductus arteriosus' supported by the sentence: 'OBJECTIVE: To evaluate the effect of intravenous ibuprofen and indomethacin for treatment of patent ductus arteriosus (PDA) on mesenteric and renal blood flow velocity in preterm infants.'?,"No, the statement does not provide direct or indirect support for the phrase ""Ibuprofen treats patent ductus arteriosus."" The objective only mentions that they will evaluate the effect of ibuprofen on PDA in preterm infants but it does not confirm that ibuprofen treats PDA. Further investigation into the results and conclusions sections would be necessary for determining if there is any evidence for treatment efficacy." +7732956,Ibuprofen treats Pain,1048,"The WOMAC detected significant differences between ibuprofen and placebo for pain and physical functioning, whereas the SF-36 detected differences for the bodily pain subscale.",True,"Is the triple 'Ibuprofen treats Pain' supported by the sentence: 'The WOMAC detected significant differences between ibuprofen and placebo for pain and physical functioning, whereas the SF-36 detected differences for the bodily pain subscale.'?","Yes, the phrase ""Ibuprofen treats pain"" does receive indirect support from the statement provided. The statement indicates that there were significant differences in pain levels between participants who took ibuprofen versus those who took a placebo in both WOMAC (Western Ontario and McMaster Universities Arthritis Index) and SF-36 (Short Form 36 Health Survey) assessments. Specifically, it mentions that ibuprofen showed efficacy in reducing pain as measured by WOMAC for pain and physical functioning as well as by SF-36 for bodily pain subscale. This implies that ibuprofen consumption can lead to reduced pain levels compared to not taking ibuprofen (placebo), which supports the claim that ibuprofen treats pain. + + However, it is important to note that while these results suggest that ibuprofen can help alleviate pain in certain contexts (such as in arthritis patients, as suggested by WOMAC), they do not necessarily mean that ibuprofen will be effective in treating all types of pain experienced by all individuals. Further studies would be needed to establish more generalizable conclusions about ibuprofen's" +7686895,Ibuprofen treats arthritic joint disease,1049,"I take ibuprofen regularly for my arthritis, but I've heard that it may lead to kidney damage.",False,"Is the triple 'Ibuprofen treats arthritic joint disease' supported by the sentence: 'I take ibuprofen regularly for my arthritis, but I've heard that it may lead to kidney damage.'?","No, the statement ""I take ibuprofen regularly for my arthritis, but I've heard that it may lead to kidney damage"" does not provide indirect support for the phrase ""Ibuprofen treats arthritic joint disease."" + + Although this statement suggests that ibuprofen is used for arthritis management, it does not confirm that ibuprofen treats arthritic joint disease. Furthermore, it introduces potential kidney damage as a side effect of ibuprofen use, which does not contribute positively to its support as a treatment for arthritis. Instead, it highlights potential risks associated with its long-term use. + + To provide indirect support for ""Ibuprofen treats arthritic joint disease,"" one could consider statements that demonstrate improved joint health, reduced pain, or increased mobility associated with ibuprofen use in arthritis patients. However, statements highlighting potential side effects do not contribute positively toward supporting ibuprofen as an effective treatment for arthritic joint disease." +7258310,Ibuprofen treats Fever,1050,Paracetamol or ibuprofen in febrile children.,True,Is the triple 'Ibuprofen treats Fever' supported by the sentence: 'Paracetamol or ibuprofen in febrile children.'?,"Yes, the statement ""Paracetamol or ibuprofen in febrile children"" does provide indirect support for the claim that ibuprofen treats fever. This is because ibuprofen is explicitly mentioned as one of the medications being recommended for febrile children. The term ""febrile"" refers to having a fever. Therefore, by suggesting ibuprofen as an option for managing fever in children, it implies that ibuprofen has some efficacy in treating fever symptoms. However, it is important to note that while this statement supports ibuprofen's use for fever reduction, it does not offer direct evidence on ibuprofen's specific therapeutic effects compared to other treatments or placebo." +7210912,Ibuprofen treats Toothache,1051,"A double-blind, parallel-group study compared the analgesic efficacy of rofecoxib to placebo and ibuprofen in 102 patients with dental pain.",True,"Is the triple 'Ibuprofen treats Toothache' supported by the sentence: 'A double-blind, parallel-group study compared the analgesic efficacy of rofecoxib to placebo and ibuprofen in 102 patients with dental pain.'?","Yes, the statement does provide indirect support for the phrase ""Ibuprofen treats Toothache"". The study in question compares the efficacy of rofecoxib (a non-steroidal anti-inflammatory drug) and ibuprofen in treating dental pain in patients. By implication, if rofecoxib is found to be effective in treating dental pain (which it presumably is since it was compared to ibuprofen), then ibuprofen would also be expected to be effective in treating dental pain (toothache) since it was used as a positive control in the study. However, it is important to note that while this study provides indirect evidence for ibuprofen's effectiveness in treating toothache, it does not constitute direct evidence, as it was not specifically designed to test that claim in isolation." +25984950,Cefmenoxime treats bacterial infectious disease,1052,Cefmenoxime versus cefoxitin in the treatment of serious bacterial infections.,True,Is the triple 'Cefmenoxime treats bacterial infectious disease' supported by the sentence: 'Cefmenoxime versus cefoxitin in the treatment of serious bacterial infections.'?,"Yes, the phrase ""Cefmenoxime treats bacterial infectious disease"" does receive indirect support from the statement: ""Cefmenoxime versus cefoxitin in the treatment of serious bacterial infections."" + + The reason for my affirmative answer is that Cefmenoxime is being compared with another antibiotic (cefoxitin) for treating ""serious bacterial infections."" This implies that Cefmenoxime has some efficacy against bacterial infections; otherwise, it would not be included in such a study. However, it is essential to emphasize that indirect support does not equate to definitive proof. Further investigation would be required to establish Cefmenoxime's precise therapeutic effects on various bacterial infections and its safety profile." +21500374,Ivabradine treats hypotensive disorder,1053,"These are: the association of dobutamine infusion with amiodarone or ivabradine in patients with symptomatic hypotension, and high-dose furosemide associated to hypertonic saline solution, levosimendan, hydralazine/isosorbide dinitrate, sodium nitroprusside or ivabradine in hemodynamically stable patients.",False,"Is the triple 'Ivabradine treats hypotensive disorder' supported by the sentence: 'These are: the association of dobutamine infusion with amiodarone or ivabradine in patients with symptomatic hypotension, and high-dose furosemide associated to hypertonic saline solution, levosimendan, hydralazine/isosorbide dinitrate, sodium nitroprusside or ivabradine in hemodynamically stable patients.'?","No, the phrase ""Ivabradine treats hypotensive disorder"" does not receive direct support from the statement provided. The statement lists combinations of treatments for symptomatic hypotension or hemodynamically stable patients, one of which includes ivabradine; however, it does not explicitly claim that ivabradine treats hypotensive disorder on its own. Indirect support might be inferred if ivabradine were consistently paired with less potent treatments, suggesting it plays an active role in managing hypotension; but in this case, ivabradine is associated with both stronger treatments (e.g., dobutamine infusion) and weaker treatments (e.g., high-dose furosemide), which weakens any potential indirect support for ivabradine as an effective standalone treatment for hypotensive disorder." +18841652,Ivabradine treats toxic shock syndrome,1054,If Channel Inhibition With Ivabradine Does Not Improve Cardiac and Vascular Function in Experimental Septic Shock.,False,Is the triple 'Ivabradine treats toxic shock syndrome' supported by the sentence: 'If Channel Inhibition With Ivabradine Does Not Improve Cardiac and Vascular Function in Experimental Septic Shock.'?,"No, the statement ""If Channel Inhibition With Ivabradine Does Not Improve Cardiac and Vascular Function in Experimental Septic Shock"" does not provide indirect support for the claim that ""Ivabradine treats toxic shock syndrome."" The statement is actually negatively framed, suggesting that channel inhibition with Ivabradine does not have beneficial effects on cardiac and vascular function in experimental septic shock. Septic shock is a severe form of sepsis that can lead to tissue damage, organ failure, and death; it is not equivalent to toxic shock syndrome, which is a distinct condition often associated with tampon use in menstruating women and caused by certain strains of Staphylococcus aureus or Streptococcus pyogenes that produce exotoxins. + + To provide indirect support for the claim that Ivabradine treats toxic shock syndrome, one would need evidence suggesting that Ivabradine has beneficial effects on cardiac and vascular function in toxic shock syndrome specifically, not merely in sepsis or experimental septic shock. Additionally, it would be important for any such study to control for potential confounding factors that could influence Ivabradine's" +18126606,Ivabradine treats mitral valve stenosis,1055,Ivabradine thus can be used effectively and safely in patients with MS in normal sinus rhythm who are intolerant or contraindicated for beta-blocker therapy.,False,Is the triple 'Ivabradine treats mitral valve stenosis' supported by the sentence: 'Ivabradine thus can be used effectively and safely in patients with MS in normal sinus rhythm who are intolerant or contraindicated for beta-blocker therapy.'?,"No, the phrase ""Ivabradine treats mitral valve stenosis"" does not receive indirect support from the statement: ""Ivabradine thus can be used effectively and safely in patients with MS in normal sinus rhythm who are intolerant or contraindicated for beta-blocker therapy."" + + The statement suggests that ivabradine can be used as an alternative treatment for patients with mitral stenosis (MS) who cannot take beta-blockers due to intolerance or contraindications. However, it does not imply that ivabradine can treat mitral valve stenosis itself. Rather, it suggests that ivabradine can help manage symptoms in certain patient populations by reducing heart rate without using beta-blockers. Therefore, there is no indirect support for ivabradine treating mitral valve stenosis based on this statement alone." +17604342,Ivabradine treats atrial fibrillation,1056,Ivabradine is ineffective in atrial fibrillation.,False,Is the triple 'Ivabradine treats atrial fibrillation' supported by the sentence: 'Ivabradine is ineffective in atrial fibrillation.'?,"No, the statement ""Ivabradine is ineffective in atrial fibrillation"" does not provide indirect support for the claim that ""Ivabradine treats atrial fibrillation."" In fact, it suggests quite the opposite. + + The statement implies that ivabradine does not have a positive effect on atrial fibrillation, which is a type of irregular heartbeat. This is in line with the definition of ineffectiveness - that a treatment does not produce a desired result. Therefore, it does not support but rather contradicts the claim that ivabradine treats atrial fibrillation. + + It is important to distinguish between a treatment being ineffective and it being harmful. In this case, ""ineffective"" means that ivabradine does not help in treating atrial fibrillation; it does not necessarily mean that ivabradine worsens the condition or causes harm when used in atrial fibrillation patients. However, based on the information provided, there is no evidence supporting the use of ivabradine as a treatment for atrial fibrillation." +17604340,Ivabradine treats diastolic heart failure,1057,The aim of the study was to compare the therapeutic effects of ivabradine in diastolic heart failure with preserved left ventricular systolic function.,True,Is the triple 'Ivabradine treats diastolic heart failure' supported by the sentence: 'The aim of the study was to compare the therapeutic effects of ivabradine in diastolic heart failure with preserved left ventricular systolic function.'?,"Yes, the statement does provide indirect support for the phrase ""Ivabradine treats diastolic heart failure."" The aim of the study is to compare the therapeutic effects of ivabradine in diastolic heart failure with preserved left ventricular systolic function. This implies that ivabradine is being used as a treatment for diastolic heart failure in the context of this study. However, it is important to note that indirect support does not equate to definitive proof that ivabradine treats diastolic heart failure. The results and conclusions from the study itself would need to be evaluated in order to make such an assertion." +15681673,Ivabradine treats multiple organ dysfunction syndrome,1058,CONCLUSIONS: The MODI (f)Y trial is the first application of ivabradine as a pure heart rate reducing agent in MODS patients.,True,Is the triple 'Ivabradine treats multiple organ dysfunction syndrome' supported by the sentence: 'CONCLUSIONS: The MODI (f)Y trial is the first application of ivabradine as a pure heart rate reducing agent in MODS patients.'?,"Yes, the statement does provide indirect support for the phrase ""Ivabradine treats multiple organ dysfunction syndrome (MODS)"". The CONCLUSIONS section of the abstract mentions that the MODI (f)Y trial is the first application of ivabradine as a pure heart rate reducing agent in MODS patients. This implies that ivabradine has been used in treating patients with MODS by targeting heart rate reduction specifically. However, it is important to note that treating multiple organ dysfunction syndrome is a complex process that involves addressing various underlying conditions and organ failures. Therefore, while ivabradine may contribute positively to the treatment regimen for MODS patients by reducing heart rate, it does not necessarily imply that ivabradine alone can treat MODS entirely. Further studies would be needed to establish its efficacy in treating MODS directly." +15641743,Ivabradine treats systolic heart failure,1059,Ivabradine added to guidelines-based therapy in systolic heart failure patients.,True,Is the triple 'Ivabradine treats systolic heart failure' supported by the sentence: 'Ivabradine added to guidelines-based therapy in systolic heart failure patients.'?,"Yes, the statement ""Ivabradine added to guidelines-based therapy in systolic heart failure patients"" does provide indirect support for the claim that ""Ivabradine treats systolic heart failure."" By stating that ivabradine is added to guidelines-based therapy specifically for patients with systolic heart failure, it implies that ivabradine has some beneficial effect on systolic heart failure management when used in conjunction with standard therapies. However, it is important to note that indirect support does not equate to definitive proof; further studies would be required to establish direct causality between ivabradine use and improvements in systolic heart failure outcomes." +13559450,Ivabradine treats Tachycardia,1060,"Clinical studies proved the efficacy of ivabradine in patients with stable angina, while clinical data are awaited to verify its probable value in the treatment of atrial tachyarrhythmias and tachycardia due to ventricular dysfunction.",False,"Is the triple 'Ivabradine treats Tachycardia' supported by the sentence: 'Clinical studies proved the efficacy of ivabradine in patients with stable angina, while clinical data are awaited to verify its probable value in the treatment of atrial tachyarrhythmias and tachycardia due to ventricular dysfunction.'?","No, the phrase ""Ivabradine treats Tachycardia"" does not receive direct support from the statement provided. The statement mentions that clinical studies have proven the efficacy of ivabradine in patients with stable angina, but it also states that clinical data is still awaited to verify its probable value in the treatment of atrial tachyarrhythmias and tachycardia due to ventricular dysfunction. Therefore, while there is potential support for ivabradine's effectiveness in treating tachycardia, it is not yet proven by clinical studies as stated in the given context." +12424888,Ivabradine treats coronary artery disorder,1061,"The effective drug, ivabradine, has demonstrated anti-anginal, anti-ischemic efficacy and now is being tested for its effect on survival in patients with coronary artery disease and impaired left ventricular function, as well as for heart failure.",True,"Is the triple 'Ivabradine treats coronary artery disorder' supported by the sentence: 'The effective drug, ivabradine, has demonstrated anti-anginal, anti-ischemic efficacy and now is being tested for its effect on survival in patients with coronary artery disease and impaired left ventricular function, as well as for heart failure.'?","Yes, the statement does provide indirect support for the phrase ""Ivabradine treats coronary artery disorder"". The statement highlights ivabradine as an effective drug for treating anti-anginal and anti-ischemic conditions, which are both closely related to coronary artery disorders. Furthermore, it mentions that ivabradine is being tested for its effect on survival in patients with coronary artery disease and impaired left ventricular function, which indicates further investigation into its potential therapeutic benefits for coronary artery disorders. However, it is important to note that while there is support for ivabradine as a potential treatment option for coronary artery disorders, more direct evidence would be needed for a definitive conclusion on its efficacy in treating coronary artery disorders specifically." +12164130,Ivabradine treats Stable angina,1062,New agent ivabradine (Procoralan) for treatment of chronic stable angina.,True,Is the triple 'Ivabradine treats Stable angina' supported by the sentence: 'New agent ivabradine (Procoralan) for treatment of chronic stable angina.'?,"Yes, the phrase ""Ivabradine treats Stable angina"" does receive indirect support from the statement: ""New agent ivabradine (Procoralan) for treatment of chronic stable angina."" + + + + The statement explicitly mentions ivabradine as a new agent for treating chronic stable angina. This implies that ivabradine has been found to be effective in treating chronic stable angina in some capacity. Therefore, it lends indirect support to the claim that ivabradine treats stable angina. However, it should be noted that this evidence is indirect, as it does not provide specific details on the nature or extent of ivabradine's therapeutic effect on stable angina. Additionally, further investigation would be necessary to evaluate any potential side effects, contraindications, or other factors that may influence ivabradine's suitability as a treatment for stable angina." +11342280,Ivabradine treats cardiovascular disorder,1063,Heart rate lowering by specific and selective I(f) current inhibition with ivabradine: a new therapeutic perspective in cardiovascular disease.,True,Is the triple 'Ivabradine treats cardiovascular disorder' supported by the sentence: 'Heart rate lowering by specific and selective I(f) current inhibition with ivabradine: a new therapeutic perspective in cardiovascular disease.'?,"Yes, the statement ""Heart rate lowering by specific and selective I(f) current inhibition with ivabradine: a new therapeutic perspective in cardiovascular disease"" does provide indirect support for the claim that ""Ivabradine treats cardiovascular disorder."" This is because it suggests that ivabradine has an impact on heart rate through specific inhibition of the I(f) current, which can be considered as a new therapeutic perspective in managing cardiovascular diseases. However, it should be noted that indirect support does not equate to definitive proof; further investigation into specific studies and evidence would be required for stronger support." +26843374,Cefixime treats tonsillitis,1064,These results show that cefixime once daily is at least as effective as penicillin V t.i.d. in pharyngitis and tonsillitis in children.,True,Is the triple 'Cefixime treats tonsillitis' supported by the sentence: 'These results show that cefixime once daily is at least as effective as penicillin V t.i.d. in pharyngitis and tonsillitis in children.'?,"Yes, the statement ""These results show that cefixime once daily is at least as effective as penicillin V t.i.d. in pharyngitis and tonsillitis in children"" does provide indirect support for the claim that ""Cefixime treats tonsillitis"". The study demonstrates that cefixime is effective in treating pharyngitis and tonsillitis in children at least as well as penicillin V, which is commonly used for treating tonsillitis. However, it is important to note that indirect support does not equate to definitive proof; it simply suggests that further investigation could potentially strengthen the claim that cefixime treats tonsillitis." +23970374,Cefixime treats Infection,1065,The aim of this study is to evaluate cefixime for the treatment of osteoarticular infections in pediatric SCD patients by retrospective design.,True,Is the triple 'Cefixime treats Infection' supported by the sentence: 'The aim of this study is to evaluate cefixime for the treatment of osteoarticular infections in pediatric SCD patients by retrospective design.'?,"Yes, the statement ""Cefixime treats Infection"" does receive indirect support from the provided statement: ""The aim of this study is to evaluate cefixime for the treatment of osteoarticular infections in pediatric SCD patients by retrospective design."" + + The reason for my affirmative answer is that the study aims to evaluate cefixime as a treatment option for osteoarticular infections in pediatric patients with Sickle Cell Disease (SCD). This implies that cefixime is being considered as a potential therapeutic agent for treating infections in these patients. + + However, it is essential to note that direct support for the claim would require empirical evidence demonstrating cefixime's efficacy in treating infections in pediatric SCD patients specifically. The statement only indicates that cefixime is being studied for such use; it does not confirm that cefixime successfully treats infections in these patients. + + In summary, while there is indirect support for cefixime treating infections from the provided statement due to its focus on studying cefixime as an infection treatment option in pediatric SCD patients" +22544340,Cefixime treats pharyngitis,1066,Purpose: To report a case of Acute bilateral angle closure and Myopia following oral Cefixime therapy for pharyngitis.,False,Is the triple 'Cefixime treats pharyngitis' supported by the sentence: 'Purpose: To report a case of Acute bilateral angle closure and Myopia following oral Cefixime therapy for pharyngitis.'?,"No, the statement does not provide direct or indirect support for the phrase ""Cefixime treats pharyngitis."" In fact, it seems to suggest an adverse reaction associated with Cefixime therapy for pharyngitis. The purpose of the report is to document a case of acute bilateral angle closure and myopia following oral Cefixime therapy for pharyngitis, implying that Cefixime might be a potential trigger for these conditions in some individuals rather than an effective treatment for pharyngitis." +22138225,Cefixime treats syphilis,1067,DISCUSSION: Demonstration of efficacy of cefixime in the treatment of active syphilis in this Phase 2 trial among non-pregnant women will inform a proposed randomized controlled trial to evaluate cefixime as an alternative treatment for pregnant women with active syphilis to evaluate prevention of congenital syphilis.,True,Is the triple 'Cefixime treats syphilis' supported by the sentence: 'DISCUSSION: Demonstration of efficacy of cefixime in the treatment of active syphilis in this Phase 2 trial among non-pregnant women will inform a proposed randomized controlled trial to evaluate cefixime as an alternative treatment for pregnant women with active syphilis to evaluate prevention of congenital syphilis.'?,"Yes, the statement does provide indirect support for the phrase ""Cefixime treats syphilis."" The discussion is about a Phase 2 trial demonstrating the efficacy of cefixime in treating active syphilis in non-pregnant women. This forms part of the rationale for proposing a randomized controlled trial to evaluate cefixime as an alternative treatment for pregnant women with active syphilis, specifically aiming to prevent congenital syphilis. The fact that medical researchers are considering cefixime as a potential treatment for syphilis indicates that they see some merit in its therapeutic application against the disease. However, it is essential to highlight that further rigorous clinical trials are needed before definitively stating that ""Cefixime treats syphilis.""" +20619094,Cefixime treats bronchitis,1068,"Two weeks following her return to France, the patient presented with an episode of bronchitis and received 5 days of treatment with cefixime (a third-generation cephalosporin).",False,"Is the triple 'Cefixime treats bronchitis' supported by the sentence: 'Two weeks following her return to France, the patient presented with an episode of bronchitis and received 5 days of treatment with cefixime (a third-generation cephalosporin).'?","No, the statement ""Two weeks following her return to France, the patient presented with an episode of bronchitis and received 5 days of treatment with cefixime (a third-generation cephalosporin)"" does not provide direct or indirect support for the claim ""Cefixime treats bronchitis."" This is because correlation does not imply causation; even though it is mentioned that cefixime was administered during an episode of bronchitis, it does not necessarily mean that cefixime was responsible for treating it. To establish support for such a claim, there would need to be evidence from clinical trials demonstrating that cefixime is effective in treating bronchitis." +12941415,Cefixime treats otitis media,1069,Efficacy and tolerability of cefixime in otitis media.,True,Is the triple 'Cefixime treats otitis media' supported by the sentence: 'Efficacy and tolerability of cefixime in otitis media.'?,"Yes, the phrase ""Cefixime treats otitis media"" does receive indirect support from the statement: ""Efficacy and tolerability of cefixime in otitis media."" + + The statement suggests that cefixime has been studied in relation to otitis media, which implies that there is some interest in its potential as a treatment for that condition. Furthermore, it mentions ""efficacy,"" which refers to the ability to produce a desired result; in this context, that would mean reducing symptoms or curing otitis media. Therefore, it can be inferred that cefixime has demonstrated some level of efficacy in treating otitis media under whatever conditions were studied. + + However, it is important to note that indirect support does not equate to definitive proof. This statement does not provide direct evidence that every patient will respond positively to cefixime treatment for otitis media, nor does it specify any potential side effects or contraindications. Further investigation would be necessary to establish those details." +8827692,Cefixime treats gonorrhea,1070,A randomized trial of ciprofloxacin versus cefixime for treatment of gonorrhea after rapid emergence of gonococcal ciprofloxacin resistance in The Philippines.,True,Is the triple 'Cefixime treats gonorrhea' supported by the sentence: 'A randomized trial of ciprofloxacin versus cefixime for treatment of gonorrhea after rapid emergence of gonococcal ciprofloxacin resistance in The Philippines.'?,"Yes, the statement does provide indirect support for the claim that ""Cefixime treats gonorrhea"". The randomized trial mentioned in the statement compares two antibiotics, ciprofloxacin and cefixime, specifically for treating gonorrhea after rapid emergence of gonococcal ciprofloxacin resistance in The Philippines. This implies that cefixime is an antibiotic used in treating gonorrhea under certain circumstances (in this case when there is resistance to ciprofloxacin). However, it is important to note that antibiotic resistance can develop over time, so antibiotics may not always be effective in treating gonorrhea in every individual case." +7594422,Cefixime treats bacterial infectious disease,1071,A randomized controlled clinical study of cefetamet pivoxil (CAT) compared with cefixime (CFX) was conducted to evaluate its safety and efficacy in treating bacterial infections.,True,Is the triple 'Cefixime treats bacterial infectious disease' supported by the sentence: 'A randomized controlled clinical study of cefetamet pivoxil (CAT) compared with cefixime (CFX) was conducted to evaluate its safety and efficacy in treating bacterial infections.'?,"Yes, indirectly it does lend support. The statement mentions that a randomized controlled clinical study was conducted comparing cefetamet pivoxil (CAT) with cefixime (CFX) for treating bacterial infections. The fact that such a study was conducted implies that there is some basis for believing that cefixime could be used for treating bacterial infections since it is being compared in a clinical trial setting. However, it is important to note that indirect support does not equate to definitive proof. The statement does not provide any information about the results of the study, so we cannot determine whether cefixime was found to be safe and efficacious in treating bacterial infections in this particular study." +26078551,Ceftizoxime treats bacterial infectious disease,1072,"Eighteen children with the following bacterial infections were treated with ceftizoxime; respiratory tract infection (13), acute otitis media (1), acute intervertebral chondritis and tonsillitis (1), chronic cystitis (1), subcutaneous abscess (1) and chronic bacteremia (1).",True,"Is the triple 'Ceftizoxime treats bacterial infectious disease' supported by the sentence: 'Eighteen children with the following bacterial infections were treated with ceftizoxime; respiratory tract infection (13), acute otitis media (1), acute intervertebral chondritis and tonsillitis (1), chronic cystitis (1), subcutaneous abscess (1) and chronic bacteremia (1).'?","Yes, indirect support can be inferred from the statement provided. The claim states that eighteen children with various bacterial infections were treated using ceftizoxime. The treatment of these infections implies that ceftizoxime was used as an antimicrobial agent to combat bacterial infectious diseases in these cases. However, it should be noted that indirect support does not equate to definitive proof, as multiple factors could have contributed to the resolution of these infections. A more rigorous evaluation would require additional information such as control groups, statistical analysis, and documentation of treatment response." +25661332,Ceftizoxime treats osteomyelitis,1073,"Experience with imipenem/cilastatin and that reported for cefotaxime, ceftazidime, and ceftizoxime in the treatment of biopsy-proved osteomyelitis was compared, using data from published reports from five centers.",True,"Is the triple 'Ceftizoxime treats osteomyelitis' supported by the sentence: 'Experience with imipenem/cilastatin and that reported for cefotaxime, ceftazidime, and ceftizoxime in the treatment of biopsy-proved osteomyelitis was compared, using data from published reports from five centers.'?","Yes, indirectly it does lend some support. The statement mentions that experience with Ceftizoxime in treating osteomyelitis was reported from five centers, which implies that Ceftizoxime has been used in treating osteomyelitis in these studies. However, it doesn't provide direct evidence of Ceftizoxime treating osteomyelitis effectively as it doesn't mention the outcomes of these treatments. It would be more conclusive if there were specific data on the success rates or other measures of effectiveness for Ceftizoxime in treating osteomyelitis." +23911647,Trimetazidine treats diabetic kidney disease,1074,"In DIN and diabetic kidney diseases,TMZ treatment prevents renal injury by inactivating immune cells, attenuating renal fibrosis, inflammation, apoptosis, and histological abnormalities.",True,"Is the triple 'Trimetazidine treats diabetic kidney disease' supported by the sentence: 'In DIN and diabetic kidney diseases,TMZ treatment prevents renal injury by inactivating immune cells, attenuating renal fibrosis, inflammation, apoptosis, and histological abnormalities.'?","Yes, indirectly it does lend some support. The statement mentions that Trimetazidine (TMZ) treatment prevents renal injury in DIN (diabetic nephropathy) and diabetic kidney diseases by inactivating immune cells, attenuating renal fibrosis, inflammation, apoptosis, and histological abnormalities. This implies that TMZ has beneficial effects on diabetic kidney disease, which aligns with the phrase ""Trimetazidine treats diabetic kidney disease."" However, it is important to note that direct causality is not established in this statement; rather, it suggests a potential therapeutic benefit that would need further investigation through clinical trials to confirm efficacy in treating diabetic kidney disease." +17755056,Trimetazidine treats Cardiotoxicity,1075,Concomitant administration of trimetazidine attenuates significantly the cardiotoxicity and hepatotoxity induced by doxorubicin.,True,Is the triple 'Trimetazidine treats Cardiotoxicity' supported by the sentence: 'Concomitant administration of trimetazidine attenuates significantly the cardiotoxicity and hepatotoxity induced by doxorubicin.'?,"Yes, indirectly it does lend support. The statement suggests that when Trimetazidine is administered concomitantly (simultaneously) with doxorubicin, it significantly attenuates (lessens) the cardiotoxicity (damage to the heart) induced by doxorubicin. This implies that Trimetazidine has a protective effect on the heart against the toxicity caused by doxorubicin, thus providing indirect evidence that Trimetazidine may have a therapeutic effect in treating cardiotoxicity. However, it's important to note that this is an indirect inference based on one specific experimental setup, and further evidence would be needed to make definitive conclusions about Trimetazidine's general effectiveness in treating cardiotoxicity." +17682787,Trimetazidine treats cardiovascular disorder,1076,Defining the role of trimetazidine in the treatment of cardiovascular disorders: some insights on its role in heart failure and peripheral artery disease.,True,Is the triple 'Trimetazidine treats cardiovascular disorder' supported by the sentence: 'Defining the role of trimetazidine in the treatment of cardiovascular disorders: some insights on its role in heart failure and peripheral artery disease.'?,"Yes, the statement ""Defining the role of trimetazidine in the treatment of cardiovascular disorders: some insights on its role in heart failure and peripheral artery disease"" does lend indirect support to the claim that ""Trimetazidine treats cardiovascular disorders"". This is because it suggests that there is a defined role for trimetazidine in treating specific cardiovascular disorders such as heart failure and peripheral artery disease. However, it does not provide direct evidence that trimetazidine is effective in treating all types of cardiovascular disorders, nor does it specify the mechanism by which trimetazidine exerts its therapeutic effects. Therefore, while there is some support for the claim, it is not unequivocal evidence that trimetazidine is an effective treatment for all cardiovascular disorders." +19370408,Cefodizime treats bacterial infectious disease,1077,[Clinical experience with cefodizime in bacterial infection of children].,False,Is the triple 'Cefodizime treats bacterial infectious disease' supported by the sentence: '[Clinical experience with cefodizime in bacterial infection of children].'?,"No, the phrase ""Cefodizime treats bacterial infectious disease"" does not receive direct support from the statement: ""[Clinical experience with cefodizime in bacterial infection of children]."" + + + + The statement only indicates that there is clinical experience using cefodizime in bacterial infections among children; it does not provide any information about the outcome of treatment or whether cefodizime was responsible for treating the infections. In order for there to be direct support for the claim that cefodizime treats bacterial infectious disease, there would need to be evidence that cefodizime was administered and resulted in successful treatment of bacterial infections in children. Indirect support might come from studies that show cefodizime is effective in treating bacterial infections in general, but that is not provided in this statement alone." +9968932,Acadesine treats B-cell chronic lymphocytic leukemia,1078,These results suggest a new pathway involving AMPK in the control of apoptosis in B-CLL cells and raise the possibility of using acadesine in B-CLL treatment.,True,Is the triple 'Acadesine treats B-cell chronic lymphocytic leukemia' supported by the sentence: 'These results suggest a new pathway involving AMPK in the control of apoptosis in B-CLL cells and raise the possibility of using acadesine in B-CLL treatment.'?,"Yes, the statement does provide indirect support for the phrase ""Acadesine treats B-cell chronic lymphocytic leukemia"" (B-CLL). The statement suggests that Acadesine (also known as AICAR) activates AMPK in B-CLL cells, which leads to apoptosis (programmed cell death). This finding implies that Acadesine could potentially be used as a treatment for B-CLL by promoting the death of malignant cells. However, it is important to note that this statement only provides indirect evidence as it comes from an in vitro study using cell lines; further investigation is required to confirm its efficacy and safety in clinical settings before making definitive conclusions about its therapeutic potential for B-CLL patients." +24441273,Ranolazine treats amyotrophic lateral sclerosis,1079,DISCUSSION: Ranolazine was well tolerated in ALS up to 2000 mg daily with gastrointestinal side effects being the most frequent.,False,Is the triple 'Ranolazine treats amyotrophic lateral sclerosis' supported by the sentence: 'DISCUSSION: Ranolazine was well tolerated in ALS up to 2000 mg daily with gastrointestinal side effects being the most frequent.'?,"No, the phrase ""Ranolazine treats amyotrophic lateral sclerosis"" does not receive indirect support from the statement provided. The statement discusses the tolerability and side effects of Ranolazine in ALS patients but it does not provide evidence on its therapeutic effect on ALS. Therefore, it does not support the claim that Ranolazine treats ALS." +16822044,Ranolazine treats type 2 diabetes mellitus,1080,Evaluation of ranolazine in patients with type 2 diabetes mellitus and chronic stable angina: results from the TERISA randomized clinical trial (Type 2 Diabetes Evaluation of Ranolazine in Subjects With Chronic Stable Angina).,False,Is the triple 'Ranolazine treats type 2 diabetes mellitus' supported by the sentence: 'Evaluation of ranolazine in patients with type 2 diabetes mellitus and chronic stable angina: results from the TERISA randomized clinical trial (Type 2 Diabetes Evaluation of Ranolazine in Subjects With Chronic Stable Angina).'?,"No, the statement does not provide direct support for the claim that ""Ranolazine treats type 2 diabetes mellitus."" The TERISA randomized clinical trial investigates ranolazine in patients with type 2 diabetes mellitus and chronic stable angina; however, it does not explicitly state that ranolazine treats type 2 diabetes mellitus. The results from such a study may suggest potential benefits for patients suffering from both conditions (type 2 diabetes mellitus and chronic stable angina) when treated with ranolazine; nonetheless, it does not provide conclusive evidence that ranolazine is a treatment for type 2 diabetes mellitus in isolation. + + A more thorough analysis would require examining additional studies specifically targeting ranolazine as a treatment for type 2 diabetes mellitus without comorbidities like chronic stable angina. This would help establish whether ranolazine has standalone therapeutic potential for type 2 diabetes mellitus patients without any confounding factors related to other medical conditions or drug interactions. + + It is essential to approach scientific statements cautiously, ensuring that they align with empirical evidence derived from rigorous experimental" +15243162,Ranolazine treats diastolic heart failure,1081,"Moreover, ranolazine holds potential promise to be effective in treatment of atrial fibrillation and diastolic heart failure.",True,"Is the triple 'Ranolazine treats diastolic heart failure' supported by the sentence: 'Moreover, ranolazine holds potential promise to be effective in treatment of atrial fibrillation and diastolic heart failure.'?","Yes, the statement does provide indirect support for the claim that ""Ranolazine treats diastolic heart failure."" The reason is that it mentions ranolazine as having potential effectiveness in treating diastolic heart failure, which implies that there is some evidence or rationale suggesting its use in treating this condition. However, it's important to note that indirect support does not equate to definitive proof, and further investigation would be necessary to confirm ranolazine's efficacy in treating diastolic heart failure." +14672486,Ranolazine treats long QT syndrome,1082,"Small clinical trials suggest that ranolazine may have a role in the treatment of patients with non-ST-elevation acute coronary syndrome, atrial fibrillation, long QT syndromes, and sinus node dysfunction.",True,"Is the triple 'Ranolazine treats long QT syndrome' supported by the sentence: 'Small clinical trials suggest that ranolazine may have a role in the treatment of patients with non-ST-elevation acute coronary syndrome, atrial fibrillation, long QT syndromes, and sinus node dysfunction.'?","Yes, while indirectly, the statement does lend some support to the claim that ranolazine may be used in treating long QT syndrome. Small clinical trials have suggested that ranolazine could play a part in managing patients with non-ST-elevation acute coronary syndrome, atrial fibrillation, long QT syndromes, and sinus node dysfunction. The mention of long QT syndromes in this context implies that there is some evidence pointing towards its potential therapeutic use for this condition; however, it is crucial to examine more robust studies before making definitive conclusions about its efficacy in treating long QT syndrome specifically. + + Further investigation is necessary because long QT syndrome is a complex genetic disorder that involves various genes responsible for ion channel functioning in cardiac cells. To confidently assert that ranolazine can treat long QT syndrome, researchers should establish its mechanism of action in addressing specific ion channel abnormalities underlying different types of long QT syndrome. This would require thorough preclinical studies followed by large-scale clinical trials that consider various factors such as dosage, duration of treatment, genetic heterogeneity among patients, potential side effects, and interactions with other" +13891593,Ranolazine treats atrial fibrillation,1083,"Recent studies have increased interest in fast-unbinding Na(+) channel blockers like vernakalant (RSD1235) and ranolazine for AF therapy, but the mechanism of efficacy is poorly understood.",False,"Is the triple 'Ranolazine treats atrial fibrillation' supported by the sentence: 'Recent studies have increased interest in fast-unbinding Na(+) channel blockers like vernakalant (RSD1235) and ranolazine for AF therapy, but the mechanism of efficacy is poorly understood.'?","No, the statement does not provide direct or indirect support for the phrase ""Ranolazine treats atrial fibrillation."" The statement mentions that recent studies have increased interest in fast-unbinding Na(+) channel blockers like vernakalant (RSD1235) and ranolazine for atrial fibrillation (AF) therapy. However, it also mentions that the mechanism of efficacy is poorly understood, which implies that there is no clear evidence or understanding of how these drugs treat atrial fibrillation. Therefore, it is not appropriate to conclude that ranolazine treats atrial fibrillation based on this statement alone." +12975239,Ranolazine treats coronary artery disorder,1084,Ranolazine for the management of coronary artery disease.,True,Is the triple 'Ranolazine treats coronary artery disorder' supported by the sentence: 'Ranolazine for the management of coronary artery disease.'?,"Yes, the statement ""Ranolazine for the management of coronary artery disease"" does provide indirect support for the phrase ""Ranolazine treats coronary artery disorder."" This is because treating a disorder is often part of its management. Ranolazine is mentioned as being used in managing coronary artery disease, which implies that it has some therapeutic effect on the disorder itself. However, it is important to note that management can also include other aspects such as prevention, monitoring, or symptom relief, so direct support would require a statement specifically mentioning treatment or curing coronary artery disorder." +10629663,Ranolazine treats Angina pectoris,1085,"Effects of a new metabolic modulator, ranolazine, on exercise tolerance in angina pectoris patients treated with beta-blocker or diltiazem.",True,"Is the triple 'Ranolazine treats Angina pectoris' supported by the sentence: 'Effects of a new metabolic modulator, ranolazine, on exercise tolerance in angina pectoris patients treated with beta-blocker or diltiazem.'?","Yes, the statement does provide indirect support for the claim that ""Ranolazine treats Angina pectoris"". The study mentioned investigates the effects of ranolazine on exercise tolerance in angina pectoris patients who were already being treated with either beta-blockers or diltiazem. The fact that such a study was conducted suggests that there is some basis for believing that ranolazine may have beneficial effects in treating angina pectoris, otherwise there would be no reason to study it in this context. However, it is important to note that indirect support does not equate to definitive proof. The study would need to be evaluated in its entirety, including its design, sample size, statistical analysis, and results, before making any firm conclusions about the efficacy of ranolazine for treating angina pectoris." +9302562,Ranolazine treats myocardial ischemia,1086,Ranolazine has been shown to improve exercise-induced myocardial ischaemia and to lessen the severity of angina in the setting of chronic ischaemic heart disease.,True,Is the triple 'Ranolazine treats myocardial ischemia' supported by the sentence: 'Ranolazine has been shown to improve exercise-induced myocardial ischaemia and to lessen the severity of angina in the setting of chronic ischaemic heart disease.'?,"Yes, the statement ""Ranolazine has been shown to improve exercise-induced myocardial ischaemia and to lessen the severity of angina in the setting of chronic ischaemic heart disease"" does provide indirect support for the claim that ""Ranolazine treats myocardial ischemia"". + + Myocardial ischemia is defined as an insufficient supply of oxygenated blood to the heart muscle, often due to coronary artery disease (CAD). Angina is chest pain caused by reduced blood flow to the heart muscle. Both angina and myocardial ischemia can be symptoms or results of CAD. + + The provided statement suggests that ranolazine can improve exercise-induced myocardial ischaemia and lessen angina severity in patients with chronic ischaemic heart disease (which often involves CAD). This implies that ranolazine could potentially treat myocardial ischemia by improving blood flow to the heart muscle and reducing symptoms associated with ischaemia (such as angina). + + However, it is important to note that while the statement provides indirect support for the claim, it does not prove it" +9302560,Ranolazine treats cardiovascular disorder,1087,Ranolazine is a novel drug that has shown promise in the treatment of cardiovascular disease.,True,Is the triple 'Ranolazine treats cardiovascular disorder' supported by the sentence: 'Ranolazine is a novel drug that has shown promise in the treatment of cardiovascular disease.'?,"Yes, the statement ""Ranolazine is a novel drug that has shown promise in the treatment of cardiovascular disease"" does lend indirect support to the phrase ""Ranolazine treats cardiovascular disorder"". The use of the word ""treatment"" implies that there is evidence suggesting that Ranolazine can be used as a therapeutic option for cardiovascular disease. The term ""has shown promise"" further strengthens this inference by indicating that positive outcomes have been observed in studies involving Ranolazine as a treatment for cardiovascular disease. + + + However, it is important to note that ""promise"" does not necessarily equate to ""proven efficacy"". The evidence supporting Ranolazine as a treatment for cardiovascular disease may still be preliminary or not conclusive. Therefore, while there is some level of support for the claim that Ranolazine treats cardiovascular disorder based on the given statement, it would be more accurate to describe Ranolazine as a potential or promising treatment rather than a definitive one. + + + To further evaluate the claim, additional information about the nature and quality of the studies showing promise would be required. This could include details about the study" +27475554,Prednisolone treats microscopic polyangiitis,1088,Microscopic polyarteritis nodosa was diagnosed and therapy with prednisolone was begun.,True,Is the triple 'Prednisolone treats microscopic polyangiitis' supported by the sentence: 'Microscopic polyarteritis nodosa was diagnosed and therapy with prednisolone was begun.'?,"Yes, the statement ""Microscopic polyarteritis nodosa was diagnosed and therapy with prednisolone was begun"" does provide indirect support for the claim ""Prednisolone treats microscopic polyangiitis"". This is because microscopic polyarteritis nodosa is considered a form of microscopic polyangiitis (MPA), which is an ANCA-associated vasculitis that primarily affects small blood vessels [1]. Prednisolone is often used as part of standard treatment regimens for MPA [2]. + + However, it is important to note that correlation does not imply causation; therefore, while prednisolone is used in treating MPA, it does not necessarily mean that prednisolone is solely responsible for treating MPA. Other factors such as immunosuppressive therapy may also be used concurrently for optimal management [3]. Additionally, potential side effects from prednisolone should be taken into account when considering its use as therapy for MPA patients [4]. + + In summary, while there is indirect support for prednisolone being used as treatment for microscopic polyangiitis based on the provided statement, it is crucial to consider" +26307899,Prednisolone treats eye disorder,1089,A short trial with high doses of prednisolone to treat a 62 year-old woman with malignant ophthalmopathy due to Graves disease yielded an unsatisfactory improvement after 5-6 days.,False,Is the triple 'Prednisolone treats eye disorder' supported by the sentence: 'A short trial with high doses of prednisolone to treat a 62 year-old woman with malignant ophthalmopathy due to Graves disease yielded an unsatisfactory improvement after 5-6 days.'?,"No, the statement does not provide indirect support for the phrase ""Prednisolone treats eye disorder"". In fact, it suggests that prednisolone may be less effective in treating certain eye disorders, such as malignant ophthalmopathy due to Graves disease, at least in high doses over short trial periods. The evidence provided indicates an unsatisfactory improvement after 5-6 days of treatment. + + However, it is important to note that treatment response can vary significantly among patients due to factors like age, sex, disease severity, genetic predisposition, and concomitant medications. Furthermore, prednisolone has been shown to be beneficial in treating various eye disorders in other contexts. Therefore, one negative outcome does not negate prednisolone's overall efficacy in treating eye disorders but rather highlights specific situations where its effectiveness may be limited. + + In conclusion, while prednisolone may be an option for treating eye disorders in some cases, more extensive studies would be required to establish its overall efficacy in different patient populations and clinical scenarios." +25942811,Prednisolone treats sympathetic ophthalmia,1090,"[""Abolishment"" syndrome in prednisolone treatment of patients with sympathetic ophthalmia].",True,"Is the triple 'Prednisolone treats sympathetic ophthalmia' supported by the sentence: '[""Abolishment"" syndrome in prednisolone treatment of patients with sympathetic ophthalmia].'?","Yes, the phrase ""Prednisolone treats sympathetic ophthalmia"" does receive indirect support from the statement: ""Abolishment syndrome in prednisolone treatment of patients with sympathetic ophthalmia."" + + The term ""abolishment"" suggests that something is being eliminated or stopped, which in this context would be the symptoms or progression of sympathetic ophthalmia. The fact that prednisolone is mentioned in conjunction with this abolishment implies that it plays a significant role in treating or managing the condition. Therefore, it can be inferred that prednisolone has some therapeutic effect on sympathetic ophthalmia. However, it is important to note that direct evidence from randomized controlled trials would provide stronger support for this claim." +24297743,Prednisolone treats exfoliative dermatitis,1091,"A 60-year-old Aboriginal man with underlying severe exfoliative dermatitis, treated with oral azathioprine and oral prednisolone, presented with left painful red eye for ten days.",True,"Is the triple 'Prednisolone treats exfoliative dermatitis' supported by the sentence: 'A 60-year-old Aboriginal man with underlying severe exfoliative dermatitis, treated with oral azathioprine and oral prednisolone, presented with left painful red eye for ten days.'?","Yes, the statement does provide indirect support for the claim that prednisolone treats exfoliative dermatitis. The patient in question has exfoliative dermatitis and is being treated with both azathioprine and prednisolone. The fact that they were prescribed prednisolone suggests that it is considered an effective treatment for their condition. However, it is important to note that correlation does not imply causation, so while prednisolone is being used in conjunction with improved health outcomes for this patient, it does not definitively prove that prednisolone is the causative agent for these improvements. Additionally, other factors such as the azathioprine treatment could also be contributing to the patient's improvement." +24291326,Prednisolone treats Anti-neutrophil cytoplasmic antibody-associated vasculitis,1092,"These findings were consistent with a diagnosis of ANCA-associated vasculitis, and treatment with prednisolone markedly improved her condition.",True,"Is the triple 'Prednisolone treats Anti-neutrophil cytoplasmic antibody-associated vasculitis' supported by the sentence: 'These findings were consistent with a diagnosis of ANCA-associated vasculitis, and treatment with prednisolone markedly improved her condition.'?","Yes, the phrase ""Prednisolone treats Anti-neutrophil cytoplasmic antibody-associated vasculitis (ANCA-associated vasculitis)"" does receive indirect support from the statement: ""These findings were consistent with a diagnosis of ANCA-associated vasculitis, and treatment with prednisolone markedly improved her condition."" + + The statement provides evidence that prednisolone was used as a treatment for ANCA-associated vasculitis and that it led to significant improvement in the patient's condition. While not a direct causal link between prednisolone and treatment of ANCA-associated vasculitis, it does suggest that prednisolone may be an effective treatment for this condition based on these observed outcomes. + + However, it is important to note that this evidence is based on an individual case study rather than a controlled clinical trial, so further investigation would be needed before making definitive conclusions about prednisolone as an effective treatment for ANCA-associated vasculitis in general. Nonetheless, it does provide some support for the claim that prednisolone could be used as a treatment for ANCA-associated vasculitis" +24042094,Prednisolone treats biliary atresia,1093,"In 2010, a study on the advantages of budesonide compared to prednisolone in autoimmune hepatitis gave rise to experimental therapy using budesonide as an adjuvant BA treatment.",False,"Is the triple 'Prednisolone treats biliary atresia' supported by the sentence: 'In 2010, a study on the advantages of budesonide compared to prednisolone in autoimmune hepatitis gave rise to experimental therapy using budesonide as an adjuvant BA treatment.'?","No, the statement does not provide indirect support for the claim that ""Prednisolone treats biliary atresia"". The study mentioned is about autoimmune hepatitis, not biliary atresia. It compares budesonide to prednisolone in terms of advantages in treating autoimmune hepatitis. The use of budesonide as an adjuvant in biliary atresia treatment is an experimental therapy, but there is no mention of prednisolone being used for biliary atresia treatment in this context." +23981131,Prednisolone treats mycosis fungoides,1094,Prednisolone was initially used alone as an alternative treatment for CEL.,False,Is the triple 'Prednisolone treats mycosis fungoides' supported by the sentence: 'Prednisolone was initially used alone as an alternative treatment for CEL.'?,"No, the statement ""Prednisolone was initially used alone as an alternative treatment for CEL"" does not provide indirect support for the claim that ""Prednisolone treats mycosis fungoides."" This is because CEL (cutaneous T-cell lymphoma) is not the same as mycosis fungoides (MF), although MF is one type of CEL. The statement only supports that prednisolone might be an alternative treatment for some forms of CEL, not specifically for MF. The two conditions, while related, still require individual evaluation when considering treatment options due to their distinct characteristics." +23374627,Prednisolone treats trichinellosis,1095,"This study assessed the antiparasitic and anti-inflammatory effects of Citrus limon and Capsicum frutescens on murine trichinellosis and compared them with those of albendazole and prednisolone, which are conventionally used to treat trichinellosis.",True,"Is the triple 'Prednisolone treats trichinellosis' supported by the sentence: 'This study assessed the antiparasitic and anti-inflammatory effects of Citrus limon and Capsicum frutescens on murine trichinellosis and compared them with those of albendazole and prednisolone, which are conventionally used to treat trichinellosis.'?","Yes, the statement does provide indirect support for the claim that prednisolone treats trichinellosis. The study mentioned assesses the effects of prednisolone in treating murine trichinellosis, which is a step towards validating its use in treating trichinellosis. However, it is important to note that indirect support does not equate to definitive proof; further studies would be required to confirm prednisolone's efficacy in treating trichinellosis in humans conclusively." +22580782,Prednisolone treats interstitial lung disease 2,1096,Regression of Lung Squamous Cell Carcinoma after the Withdrawal of Cyclosporin A Combined With Pirfenidone Treatment in a Patient with Idiopathic Pulmonary Fibrosis.A 72-year-old man was treated with prednisolone and cyclosporine A for idiopathic pulmonary fibrosis.,False,Is the triple 'Prednisolone treats interstitial lung disease 2' supported by the sentence: 'Regression of Lung Squamous Cell Carcinoma after the Withdrawal of Cyclosporin A Combined With Pirfenidone Treatment in a Patient with Idiopathic Pulmonary Fibrosis.A 72-year-old man was treated with prednisolone and cyclosporine A for idiopathic pulmonary fibrosis.'?,"No, the statement does not provide direct or indirect support for the claim that prednisolone treats interstitial lung disease (ILD) specifically. The provided statement discusses a case where a patient with idiopathic pulmonary fibrosis (ILD) was treated using prednisolone and cyclosporine A; however, it does not establish a causal link between prednisolone use and improvement in ILD symptoms. + + Additionally, idiopathic pulmonary fibrosis is only one type of interstitial lung disease among many others. The specific type of ILD should be considered when interpreting evidence related to its treatment. + + In summary, while prednisolone may have been used in treating ILD in this particular case study, it does not necessarily mean that prednisolone is an effective treatment for interstitial lung disease in general without further investigation into its efficacy in treating specific types of ILD in controlled studies." +22500116,Prednisolone treats HIV infectious disease,1097,"The most common coexisting conditions were HIV infection (30%), prednisolone therapy (16.9%), and diabetes mellitus (15.7%).",False,"Is the triple 'Prednisolone treats HIV infectious disease' supported by the sentence: 'The most common coexisting conditions were HIV infection (30%), prednisolone therapy (16.9%), and diabetes mellitus (15.7%).'?","No, the statement does not provide direct or indirect support for the claim that prednisolone treats HIV infectious disease. The provided statement only indicates that HIV infection (30%) and prednisolone therapy (16.9%) were among the most common coexisting conditions in a specific population but does not establish any causal relationship between prednisolone therapy and improvement in HIV infection status. + + To further explain, let us consider some essential aspects related to interpreting scientific statements: + + 1. Correlation vs causation: The statement only highlights that HIV infection and prednisolone therapy frequently co-occur in this dataset; however, it does not prove that prednisolone therapy causes improvements in HIV infection status. + + 2. Context: The study population might have underlying health conditions requiring prednisolone treatment; thus, it is not surprising that prednisolone therapy is prevalent in this dataset. This does not necessarily mean that prednisolone treats HIV infection but rather that it might be prescribed for other concurrent conditions. + + 3. Scientific plausibility: Prednisolone is primarily an anti-inflammatory medication used for various conditions such as" +22130331,Prednisolone treats schizophrenia,1098,"Therefore, the effect of prednisolone can be studied as a proof of concept for immune modulation as a treatment for schizophrenia.",False,"Is the triple 'Prednisolone treats schizophrenia' supported by the sentence: 'Therefore, the effect of prednisolone can be studied as a proof of concept for immune modulation as a treatment for schizophrenia.'?","No, the phrase ""Prednisolone treats schizophrenia"" does not receive at least indirect support from the statement: ""Therefore, the effect of prednisolone can be studied as a proof of concept for immune modulation as a treatment for schizophrenia."" + + My justification for this decision is based on the following points: + + 1) The statement suggests that prednisolone is being considered as a tool for studying immune modulation in relation to schizophrenia treatment, not as a direct treatment itself. It implies that prednisolone may be helpful in understanding potential immune-related aspects that could contribute to the development of new treatments for schizophrenia; + + 2) The statement does not provide information on prednisolone's effectiveness in treating schizophrenia symptoms directly; + + 3) Prednisolone is an anti-inflammatory medication primarily used for treating various conditions such as allergies, asthma, and autoimmune disorders - not schizophrenia itself; + + 4) Although some studies suggest there might be an association between inflammation and schizophrenia, more rig" +21634207,Prednisolone treats chronic primary adrenal insufficiency,1099,The patient started insulin therapy and treatment for AD with prednisolone and fludrocortisone with good clinical response.,True,Is the triple 'Prednisolone treats chronic primary adrenal insufficiency' supported by the sentence: 'The patient started insulin therapy and treatment for AD with prednisolone and fludrocortisone with good clinical response.'?,"Yes, the statement does provide indirect support for the phrase ""Prednisolone treats chronic primary adrenal insufficiency"". The patient's good clinical response after starting treatment with prednisolone suggests that prednisolone is effective in managing adrenal insufficiency (AD). However, it should be noted that the patient was also taking fludrocortisone and insulin therapy concurrently, making it impossible to attribute the positive response solely to prednisolone based on this information alone. Nonetheless, there is some level of support for prednisolone's efficacy in treating AD from this statement." +21254689,Prednisolone treats hypersensitivity pneumonitis,1100,We aimed to determine the effect of mycophenolate mofetil (MMF) and azathioprine (AZA) on lung function and prednisolone dose in cHP patients.,False,Is the triple 'Prednisolone treats hypersensitivity pneumonitis' supported by the sentence: 'We aimed to determine the effect of mycophenolate mofetil (MMF) and azathioprine (AZA) on lung function and prednisolone dose in cHP patients.'?,"No, the statement does not provide direct or indirect support for the claim that ""Prednisolone treats hypersensitivity pneumonitis."" The study investigates the effects of mycophenolate mofetil (MMF) and azathioprine (AZA) on lung function and prednisolone dose in chronic hypersensitivity pneumonitis (cHP) patients but does not provide evidence on prednisolone's effectiveness in treating hypersensitivity pneumonitis. + + To further elaborate on why there is no indirect support for prednisolone treating hypersensitivity pneumonitis based on the given statement: + + - The study focuses on determining the impact of MMF and AZA on lung function and prednisolone dose in cHP patients; it does not evaluate prednisolone as a standalone treatment for hypersensitivity pneumonitis nor provide any correlation between prednisolone use and improvement in patients' conditions; + + - The statement does not include any information about prednisolone's therapeutic benefits for cHP patients; + + - The study does not compare prednisolone to other treatments for" +20836940,Prednisolone treats juvenile idiopathic arthritis,1101,"Here, we report the case of an 8-year-old girl with a 5-year history of multiple subcutaneous nodules on her extremities and a right wrist joint contracture who had been previously diagnosed with juvenile idiopathic arthritis and treated with salazosulfapyridine, low-dose prednisolone (PSL) and methotrexate.",True,"Is the triple 'Prednisolone treats juvenile idiopathic arthritis' supported by the sentence: 'Here, we report the case of an 8-year-old girl with a 5-year history of multiple subcutaneous nodules on her extremities and a right wrist joint contracture who had been previously diagnosed with juvenile idiopathic arthritis and treated with salazosulfapyridine, low-dose prednisolone (PSL) and methotrexate.'?","Yes, based on the statement provided, there is indirect support for the claim that prednisolone treats juvenile idiopathic arthritis. The patient in question was treated with low-dose prednisolone (PSL) as part of her treatment regimen for juvenile idiopathic arthritis. The fact that she was given prednisolone as part of her treatment suggests that it is used as a therapeutic agent for this condition, even if it is not specifically stated that prednisolone was responsible for any improvement in her condition. However, it is important to note that without additional information about the patient's response to treatment, we cannot definitively say that prednisolone was effective in treating her juvenile idiopathic arthritis." +20612701,Prednisolone treats myocarditis,1102,This is a case of EGPA relapse presenting as myocarditis despite treatment with prednisolone.,True,Is the triple 'Prednisolone treats myocarditis' supported by the sentence: 'This is a case of EGPA relapse presenting as myocarditis despite treatment with prednisolone.'?,"Yes, indirectly it does support that prednisolone may have some effect on myocarditis in the context of Eosinophilic Granulomatosis with Polyangiitis (EGPA). The statement ""This is a case of EGPA relapse presenting as myocarditis despite treatment with prednisolone"" implies that despite being on prednisolone therapy, the patient still experienced a relapse of myocarditis due to EGPA. This does not necessarily mean that prednisolone is ineffective for treating myocarditis in all cases; rather it suggests that in some cases (such as in EGPA relapse), prednisolone may not be sufficient on its own for treating myocarditis. + + To further support my interpretation: + + - A study published in Clinical Rheumatology in 2016 titled ""Prednisolone in Eosinophilic Granulomatosis with Polyangiitis: A Systematic Review"" showed that prednisolone is an important component in treating EGPA but also noted that it is often used in combination therapy due to its limitations in managing some aspects of" +17604301,Prednisolone treats cataract,1103,"Her visual acuity remained stable, despite development of a cataract from prednisolone therapy.",False,"Is the triple 'Prednisolone treats cataract' supported by the sentence: 'Her visual acuity remained stable, despite development of a cataract from prednisolone therapy.'?","No, the statement ""Her visual acuity remained stable, despite development of a cataract from prednisolone therapy"" does not provide direct or indirect support for the claim that ""Prednisolone treats cataract."" In fact, it suggests the opposite: that prednisolone therapy may cause cataracts (as evidenced by its development during treatment), while visual acuity remains stable due to factors other than prednisolone addressing the cataract itself. Prednisolone is a corticosteroid used primarily for its anti-inflammatory effects rather than treating cataracts directly; cataract surgery is typically required for visual improvement in cases where cataracts develop during prednisolone therapy." +17312178,Prednisolone treats type 2 diabetes mellitus,1104,"In this study, we hypothesized that concomitant administration of the dipeptidyl peptidase-4 inhibitor sitagliptin and prednisolone in men at high risk to develop type 2 diabetes could protect against the GC-induced diabetogenic effects.",False,"Is the triple 'Prednisolone treats type 2 diabetes mellitus' supported by the sentence: 'In this study, we hypothesized that concomitant administration of the dipeptidyl peptidase-4 inhibitor sitagliptin and prednisolone in men at high risk to develop type 2 diabetes could protect against the GC-induced diabetogenic effects.'?","No, the statement does not provide direct support for the claim that prednisolone treats type 2 diabetes mellitus. The study in question hypothesizes that prednisolone could protect against glucocorticoid (GC)-induced diabetogenic effects when administered concomitantly with sitagliptin in men at high risk for type 2 diabetes. This suggests that prednisolone might have a preventive or mitigative effect on diabetes development under specific circumstances rather than serving as a treatment for an established type 2 diabetes mellitus condition. + + The study does not demonstrate prednisolone as an independent treatment for type 2 diabetes mellitus but rather explores its potential in countering GC-induced diabetogenic effects in high-risk individuals. Therefore, it is crucial to differentiate between potential preventive properties in specific contexts from general treatment efficacy for type 2 diabetes mellitus when interpreting such evidence." +17184322,Prednisolone treats croup,1105,"Although common practice, evidence to support treatment of croup with prednisolone is scant.",False,"Is the triple 'Prednisolone treats croup' supported by the sentence: 'Although common practice, evidence to support treatment of croup with prednisolone is scant.'?","No, the statement ""Although common practice, evidence to support treatment of croup with prednisolone is scant"" does not provide indirect support for the phrase ""Prednisolone treats croup."" In fact, it suggests quite the opposite: despite widespread use (common practice), there is limited scientific evidence supporting prednisolone as an effective treatment for croup. This implies that while prednisolone might be used in treating croup, its efficacy remains uncertain and further investigation is needed to establish its therapeutic value confidently." +16852549,Prednisolone treats mature T-cell and NK-cell non-Hodgkin lymphoma,1106,"Treatment of peripheral T cell lymphoma with an intensive protocol ACEP (adriamycin, cyclophosphamide, etoposide and prednisolone) and ifosfamide showing an important response and overall survival rates.",True,"Is the triple 'Prednisolone treats mature T-cell and NK-cell non-Hodgkin lymphoma' supported by the sentence: 'Treatment of peripheral T cell lymphoma with an intensive protocol ACEP (adriamycin, cyclophosphamide, etoposide and prednisolone) and ifosfamide showing an important response and overall survival rates.'?","Yes, the statement does provide indirect support for the claim that prednisolone treats mature T-cell and NK-cell non-Hodgkin lymphoma. The statement mentions an intensive protocol ACEP (adriamycin, cyclophosphamide, etoposide and prednisolone) being used to treat peripheral T cell lymphoma (a type of non-Hodgkin lymphoma). The fact that prednisolone is included in this treatment regimen suggests that it has some therapeutic effect on these types of lymphomas. However, it is important to note that prednisolone is likely not acting alone in this treatment regimen, but rather in combination with other drugs (adriamycin, cyclophosphamide, etoposide and ifosfamide). Therefore, while there is support for prednisolone being part of an effective treatment regimen for mature T-cell and NK-cell non-Hodgkin lymphoma, it does not necessarily mean that prednisolone alone is sufficient for treatment." +16360878,Prednisolone treats ophthalmic herpes zoster,1107,"Herpes zoster ophthalmicus was suspected and treatment with i.v. acyclovir and prednisolone was commenced, which led to a gradual improvement of the clinical condition.",True,"Is the triple 'Prednisolone treats ophthalmic herpes zoster' supported by the sentence: 'Herpes zoster ophthalmicus was suspected and treatment with i.v. acyclovir and prednisolone was commenced, which led to a gradual improvement of the clinical condition.'?","Yes, the statement does provide indirect support for the phrase ""Prednisolone treats ophthalmic herpes zoster."" The patient in question was treated with both intravenous acyclovir and prednisolone for suspected herpes zoster ophthalmicus, which is a manifestation of varicella-zoster virus infection in the eye region. Following treatment initiation, there was a noted gradual improvement in their clinical condition. While correlation does not necessarily imply causation, it is plausible that prednisolone contributed positively to the observed clinical improvement given that it is an adjunctive therapy for herpes zoster ophthalmicus due to its anti-inflammatory properties. However, it is important to acknowledge that further evidence is required to establish a definitive causal relationship between prednisolone administration and clinical improvement in ophthalmic herpes zoster patients." +15441636,Prednisolone treats lipoma,1108,"Lipomas responded with less lipolysis to isoproterenol than subcutaneous fat during microdialysis, and prednisolone treatment increased lipolysis in both lipomas and subcutaneous fat.",False,"Is the triple 'Prednisolone treats lipoma' supported by the sentence: 'Lipomas responded with less lipolysis to isoproterenol than subcutaneous fat during microdialysis, and prednisolone treatment increased lipolysis in both lipomas and subcutaneous fat.'?","No, the statement does not provide direct or indirect support for the phrase ""Prednisolone treats lipoma"". The provided statement discusses how prednisolone affects lipolysis in both lipomas and subcutaneous fat during microdialysis, but it does not mention any therapeutic effect on lipomas. + + To further elaborate on the nuances involved in interpreting such evidence: + + - The statement describes an experimental setting using microdialysis, which is an invasive technique used for monitoring changes in concentrations of various substances in the extracellular space in vivo. This is an essential piece of information in understanding how these results were obtained but does not necessarily translate into direct therapeutic benefits in treating lipomas. + + - The study found that prednisolone increased lipolysis in both lipomas and subcutaneous fat; however, an increase in lipolysis does not necessarily equate to treating lipomas effectively. Lipolysis is the process by which fat cells release fatty acids into circulation, which is not always desirable as it can lead to metabolic complications if not properly regulated. + + - To establish whether prednisolone can treat" +15369817,Prednisolone treats pericarditis,1109,Treatment with prednisolone improved the pericarditis and motor nerve disturbance and the treatment with intravenous immunoglobulin improved the sensory nerve disturbance.,True,Is the triple 'Prednisolone treats pericarditis' supported by the sentence: 'Treatment with prednisolone improved the pericarditis and motor nerve disturbance and the treatment with intravenous immunoglobulin improved the sensory nerve disturbance.'?,"Yes, there is indirect support for the claim that ""Prednisolone treats pericarditis"" based on the given statement. The reason being that it mentions treatment with prednisolone improved pericarditis symptoms in a patient, which suggests that prednisolone has some therapeutic effect on pericarditis. + + However, it is important to note that while there is some evidence pointing towards prednisolone being beneficial for pericarditis treatment, it is still an indirect association since other factors could have contributed to the improvement as well. Further investigation would be necessary to establish a direct cause-and-effect relationship between prednisolone use and pericarditis treatment. + + In addition, it should be emphasized that medical treatments should be administered under professional supervision after considering potential side effects and interactions with other conditions or medications. A thorough evaluation of each individual case is essential before making treatment decisions." +15104714,Prednisolone treats pulmonary eosinophilia,1110,"Airway macrophage median percentage of red-hued area in stained sputum cytospin preparations was assessed by means of image analysis from (1) subjects with mild-to-severe asthma, subjects with nonasthmatic eosinophilic bronchitis, and healthy control subjects; (2) subjects with eosinophilic severe asthma after treatment with prednisolone; and (3) subject with noneosinophilic asthma before corticosteroid withdrawal.",False,"Is the triple 'Prednisolone treats pulmonary eosinophilia' supported by the sentence: 'Airway macrophage median percentage of red-hued area in stained sputum cytospin preparations was assessed by means of image analysis from (1) subjects with mild-to-severe asthma, subjects with nonasthmatic eosinophilic bronchitis, and healthy control subjects; (2) subjects with eosinophilic severe asthma after treatment with prednisolone; and (3) subject with noneosinophilic asthma before corticosteroid withdrawal.'?","No, the statement does not provide direct support for the claim that Prednisolone treats pulmonary eosinophilia. The statement describes an image analysis study involving subjects with different conditions such as asthma, nonasthmatic eosinophilic bronchitis, and healthy controls; as well as subjects with eosinophilic severe asthma after treatment with Prednisolone and subjects with noneosinophilic asthma before corticosteroid withdrawal. However, it does not explicitly provide information on how Prednisolone affects eosinophilia in pulmonary tissue before and after treatment in these subjects. + + + + To provide indirect support for the claim that Prednisolone treats pulmonary eosinophilia, there should be some comparison made between eosinophil levels in pulmonary tissue before treatment with Prednisolone and after treatment in these subjects. The statement does not provide any direct evidence for such comparison; thus, it does not offer substantial support for the claim that Prednisolone treats pulmonary eosinophilia based on this information alone." +14992803,Prednisolone treats aplastic anemia,1111,"We report a case of subcutaneous abscess caused by Nocardia farcinica in a 44-year-old man, who had been treated with systemic prednisolone and cyclosporin for aplastic anemia.",True,"Is the triple 'Prednisolone treats aplastic anemia' supported by the sentence: 'We report a case of subcutaneous abscess caused by Nocardia farcinica in a 44-year-old man, who had been treated with systemic prednisolone and cyclosporin for aplastic anemia.'?","Yes, there is indirect support for the claim that prednisolone treats aplastic anemia based on the given statement. The individual in question was being treated for aplastic anemia using prednisolone as part of their therapeutic regimen. The fact that they were receiving treatment for aplastic anemia suggests that prednisolone is used in managing this condition. However, it should be noted that association does not necessarily imply causation; other factors could also be influencing the treatment outcomes for aplastic anemia. Additionally, it is important to consider that prednisolone may be used in combination therapy for treating aplastic anemia in certain cases, as seen here where cyclosporin is also used alongside prednisolone." +14742554,Prednisolone treats psoriasis,1112,Genetically determined coincidence of Kaposi sarcoma and psoriasis in an HIV-negative patient after prednisolone treatment.,True,Is the triple 'Prednisolone treats psoriasis' supported by the sentence: 'Genetically determined coincidence of Kaposi sarcoma and psoriasis in an HIV-negative patient after prednisolone treatment.'?,"Yes, indirectly it does lend some support to the claim that prednisolone might be used in treating psoriasis, although it doesn't establish a direct causal relationship between prednisolone treatment and improvement in psoriasis symptoms in this particular case. + + Here's why: + + The statement mentions that an HIV-negative patient who had both Kaposi sarcoma (KS) and psoriasis experienced these conditions coincidentally after receiving prednisolone treatment. Prednisolone is a synthetic glucocorticoid often used as an anti-inflammatory medication for various conditions including dermatological disorders like psoriasis. + + While KS is not typically associated with psoriasis, both conditions can involve inflammation. Therefore, it is plausible that prednisolone was prescribed primarily for its anti-inflammatory properties rather than specifically for treating psoriasis in this case. + + However, since psoriasis is one of the conditions for which prednisolone is often prescribed, its mention in this context implies that prednisolone could have had an impact on p" +14676056,Prednisolone treats habitual spontaneous abortion,1113,Prednisolone Trial: Study protocol for a randomised controlled trial of prednisolone for women with idiopathic recurrent miscarriage and raised levels of uterine natural killer (uNK) cells in the endometrium.,True,Is the triple 'Prednisolone treats habitual spontaneous abortion' supported by the sentence: 'Prednisolone Trial: Study protocol for a randomised controlled trial of prednisolone for women with idiopathic recurrent miscarriage and raised levels of uterine natural killer (uNK) cells in the endometrium.'?,"Yes, indirectly. The statement describes a randomized controlled trial protocol for prednisolone in women with idiopathic recurrent miscarriage who have raised levels of uterine natural killer (uNK) cells in the endometrium. This implies that there is an interest in exploring prednisolone as a potential treatment for recurrent miscarriage in specific circumstances (raised uNK cells). However, it does not provide direct support for the claim that prednisolone treats habitual spontaneous abortion since the study results have not been presented yet. Therefore, any conclusion drawn from this statement should be considered preliminary and subject to further investigation." +14345678,Prednisolone treats thrombotic thrombocytopenic purpura,1114,"The second was a 6-year-old boy with acquired relapsing TTP previously managed with plasmapheresis and prednisolone, who presented with a third relapse that was treated with plasmapheresis and rituximab; he remains in remission 17 months after treatment.",True,"Is the triple 'Prednisolone treats thrombotic thrombocytopenic purpura' supported by the sentence: 'The second was a 6-year-old boy with acquired relapsing TTP previously managed with plasmapheresis and prednisolone, who presented with a third relapse that was treated with plasmapheresis and rituximab; he remains in remission 17 months after treatment.'?","Yes, the statement does provide indirect support for the phrase ""Prednisolone treats thrombotic thrombocytopenic purpura (TTP)"". The case describes a patient who had previously been managed with prednisolone during relapses of TTP, suggesting that prednisolone was an effective treatment in those instances. However, it is important to note that the patient was also treated with plasmapheresis during all relapses, making it impossible to determine whether prednisolone or plasmapheresis (or both) were responsible for managing TTP in this case. Additionally, in the most recent relapse, rituximab was used alongside plasmapheresis instead of prednisolone, which could imply that rituximab has become the preferred treatment for TTP over prednisolone in certain cases. Therefore, while there is some support for prednisolone as a treatment for TTP based on this statement, it is not unequivocal evidence due to confounding factors such as concurrent treatments and limited scope in one patient case." +14012190,Prednisolone treats angioimmunoblastic T-cell lymphoma,1115,"Three months later, AILD relapsed in spite of prednisolone treatment.",False,"Is the triple 'Prednisolone treats angioimmunoblastic T-cell lymphoma' supported by the sentence: 'Three months later, AILD relapsed in spite of prednisolone treatment.'?","No, the statement ""Three months later, AILD relapsed in spite of prednisolone treatment"" does not provide indirect support for the claim that ""Prednisolone treats angioimmunoblastic T-cell lymphoma"" (AILD). + + In fact, it suggests the opposite: that prednisolone may not be effective in treating AILD. The term ""relapsed"" indicates that the patient's condition worsened despite receiving prednisolone treatment for three months, which implies that prednisolone did not successfully manage AILD in this case. + + However, it is important to note that one case does not establish definitive evidence about a treatment's efficacy due to individual variability in response to treatments and numerous other factors that may affect patient outcomes. Further studies involving larger sample sizes would be required for stronger conclusions about prednisolone's effectiveness in treating AILD." +13758030,Prednisolone treats optic neuritis,1116,Acute generalized exanthematous pustulosis induced by high-dose prednisolone in a young woman with optic neuritis owing to disseminated encephalomyelitis.,True,Is the triple 'Prednisolone treats optic neuritis' supported by the sentence: 'Acute generalized exanthematous pustulosis induced by high-dose prednisolone in a young woman with optic neuritis owing to disseminated encephalomyelitis.'?,"Yes, indirectly it does support that prednisolone treats optic neuritis. The statement mentions that the patient had optic neuritis caused by disseminated encephalomyelitis and was treated with high-dose prednisolone, which induced acute generalized exanthematous pustulosis (AGEP). While AGEP is an adverse effect indicating high-dose prednisolone might not be ideal for everyone, it does not negate its therapeutic effect on optic neuritis in this case. Therefore, one could infer that prednisolone has been used successfully in treating optic neuritis in at least some instances. However, it is essential to acknowledge that this does not establish causality nor does it confirm prednisolone as first-line treatment for optic neuritis without further supporting evidence from clinical trials and large-scale studies that demonstrate its safety and efficacy for treating optic neuritis specifically." +13566191,Prednisolone treats follicular lymphoma,1117,"The addition of rituximab to cyclophosphamide, vincristine and prednisolone (CVP) for advanced follicular lymphoma increases median time to progression by 17 months.",False,"Is the triple 'Prednisolone treats follicular lymphoma' supported by the sentence: 'The addition of rituximab to cyclophosphamide, vincristine and prednisolone (CVP) for advanced follicular lymphoma increases median time to progression by 17 months.'?","No, the statement does not provide direct support for the claim that prednisolone treats follicular lymphoma. The statement only indicates that adding rituximab to cyclophosphamide, vincristine, and prednisolone (CVP) increases median time to progression in advanced follicular lymphoma by 17 months compared to CVP alone. This does not necessarily indicate that prednisolone has any therapeutic effect on follicular lymphoma specifically because it is given in combination therapy (CVP) in the study mentioned. To establish that prednisolone treats follicular lymphoma, there should be evidence showing its efficacy when administered alone in treating follicular lymphoma patients." +13327146,Prednisolone treats allergic bronchopulmonary aspergillosis,1118,"Here 2 cases of allergic bronchopulmonary aspergillosis in a family (brother and sister), treated with prednisolone with complete remission are reported.",True,"Is the triple 'Prednisolone treats allergic bronchopulmonary aspergillosis' supported by the sentence: 'Here 2 cases of allergic bronchopulmonary aspergillosis in a family (brother and sister), treated with prednisolone with complete remission are reported.'?","Yes, the statement does provide indirect support for the claim that prednisolone treats allergic bronchopulmonary aspergillosis (ABPA). The provided statement reports two cases of ABPA in siblings who were treated with prednisolone and achieved complete remission. However, it is important to note that while this suggests an association between prednisolone treatment and remission in these individuals, it does not definitively prove causation nor generalizability beyond these specific cases. + + The evidence provided is observational in nature, meaning that it does not control for potential confounding factors that could also influence remission in ABPA patients. For instance, other treatments, lifestyle factors, or genetic predispositions may have contributed to their recovery alongside prednisolone usage. To establish stronger evidence for prednisolone as an effective treatment for ABPA, further studies such as randomized controlled trials would be necessary. + + Nonetheless, given that prednisolone is an immunosuppressive drug commonly used for treating inflammatory conditions, it is plausible that it could help manage ABPA symptoms by reducing inflammation in response to Aspergillus antigens in suscept" +13311736,Prednisolone treats neoplasm,1119,FDG-PET was performed in rats bearing BCG granulomas or tumors before and after prednisolone treatment.,False,Is the triple 'Prednisolone treats neoplasm' supported by the sentence: 'FDG-PET was performed in rats bearing BCG granulomas or tumors before and after prednisolone treatment.'?,"No, the statement does not provide direct or indirect support for the claim that Prednisolone treats neoplasm (tumors). The study mentioned in the statement involves FDG-PET scans being performed on rats bearing BCG granulomas or tumors before and after prednisolone treatment. However, it does not provide any information about the effects of prednisolone treatment on tumor growth, progression, or regression. Therefore, it does not support the assertion that prednisolone can be used as a treatment for neoplasm. + + In order for this statement to provide indirect support for treating neoplasm, it would be necessary for there to be some evidence that prednisolone treatment led to improvements in tumor size, growth rate, or other factors related to cancer progression in these rats. Without such evidence, it is not appropriate to make conclusions about prednisolone as an effective treatment for neoplasm based solely on this statement. + + It is crucial for researchers and those interpreting their work to be cautious when drawing conclusions from available evidence. Overstating results can lead to misinformation, misleading conclusions, and potentially inappropriate" +12767794,Prednisolone treats pneumonia,1120,"After recovering from pneumonia, she was treated initially with prednisolone, 30 mg/day, and remained well until she developed hemoptysis at age 34 years.",True,"Is the triple 'Prednisolone treats pneumonia' supported by the sentence: 'After recovering from pneumonia, she was treated initially with prednisolone, 30 mg/day, and remained well until she developed hemoptysis at age 34 years.'?","Yes, while not a direct causal relationship between Prednisolone and treating pneumonia, there is indirect support for it in the statement provided. Prednisolone is known as an anti-inflammatory medication commonly used for treating various conditions such as asthma, COPD (Chronic Obstructive Pulmonary Disease), allergies, arthritis, blood disorders, kidney diseases, lupus, multiple sclerosis, certain skin conditions, thyroid disorders, and some eye disorders. It can also help reduce inflammation in pneumonia cases caused by certain autoimmune disorders like rheumatoid arthritis or lupus. + + + In this statement, we see that prednisolone was administered after recovery from pneumonia. However, we cannot rule out that prednisolone might have contributed positively towards her recovery process by controlling inflammation caused by pneumonia. It is essential to consider that prednisolone is not typically used as a primary treatment for pneumonia but may be beneficial in specific cases depending on underlying conditions triggering inflammation in pneumonia patients. + + + Nonetheless," +12190701,Prednisolone treats castration-resistant prostate carcinoma,1121,Fifteen patients 60 to 80 years old (a mean of 72 years) with hormone-refractory prostate cancer were treated with low dose prednisolone.,True,Is the triple 'Prednisolone treats castration-resistant prostate carcinoma' supported by the sentence: 'Fifteen patients 60 to 80 years old (a mean of 72 years) with hormone-refractory prostate cancer were treated with low dose prednisolone.'?,"Yes, indirectly. The statement does provide some support for the claim that prednisolone can be used in treating prostate cancer, specifically hormone-refractory prostate cancer in patients aged 60 to 80. However, it does not explicitly state that prednisolone treats castration-resistant prostate carcinoma. Castration-resistant prostate carcinoma is a specific type of hormone-refractory prostate cancer, so there is an overlap, but the statement does not cover all cases of castration-resistant prostate carcinoma. Therefore, while it provides some support, it does not fully confirm the initial phrase." +11988157,Prednisolone treats diffuse large B-cell lymphoma,1122,"CHOP (cyclophosphamide, doxorubicin, vincristine and prednisolone) has been the standard chemotherapy regimen used for diffuse large cell lymphomas for over 30 years.",True,"Is the triple 'Prednisolone treats diffuse large B-cell lymphoma' supported by the sentence: 'CHOP (cyclophosphamide, doxorubicin, vincristine and prednisolone) has been the standard chemotherapy regimen used for diffuse large cell lymphomas for over 30 years.'?","Yes, indirectly it does lend support. The statement indicates that CHOP (cyclophosphamide, doxorubicin, vincristine and prednisolone) has been used as a standard chemotherapy regimen for diffuse large cell lymphomas for over 30 years. This implies that each component of CHOP, including prednisolone, contributes positively towards treating diffuse large B-cell lymphoma as part of this combined therapy. However, it is important to note that prednisolone may not be effective in treating diffuse large B-cell lymphoma when used alone, as its primary function within the CHOP regimen is likely as an immunosuppressive agent that enhances the overall treatment efficacy when combined with other chemotherapeutic drugs in the regimen." +11889996,Prednisolone treats mucocutaneous lymph node syndrome,1123,"Six patients with Kawasaki disease (KD) were treated with prednisolone (1 to 2 mg/kg/day) for 3 days (from days 10 to 12 after the onset of the illness) after apparently unsuccessful treatment with intravenous immunoglobulin (IVIG, 2 g/kg/dose and additional 1 g/kg/dose).",True,"Is the triple 'Prednisolone treats mucocutaneous lymph node syndrome' supported by the sentence: 'Six patients with Kawasaki disease (KD) were treated with prednisolone (1 to 2 mg/kg/day) for 3 days (from days 10 to 12 after the onset of the illness) after apparently unsuccessful treatment with intravenous immunoglobulin (IVIG, 2 g/kg/dose and additional 1 g/kg/dose).'?","Yes, the statement does provide indirect support for the claim that prednisolone treats mucocutaneous lymph node syndrome (Kawasaki disease is often referred to as such). The statement describes six patients with Kawasaki disease who were treated with prednisolone after initial treatment with intravenous immunoglobulin (IVIG) was unsuccessful. The fact that prednisolone was used as a secondary treatment suggests that it was considered likely to be effective in treating Kawasaki disease, thus providing indirect support for the claim. + + However, it is important to note that this is an observational study with a small sample size, which limits the strength of the evidence. Ideally, a randomized controlled trial would be conducted to more definitively establish whether prednisolone is effective in treating Kawasaki disease. Additionally, while prednisolone may be effective in treating Kawasaki disease, it does not necessarily mean it is specifically treating mucocutaneous lymph node syndrome within Kawasaki disease, as Kawasaki disease is a complex condition that may involve multiple pathological processes." +11813573,Prednisolone treats focal segmental glomerulosclerosis,1124,"RESULTS: Of 136 patients with primary FSGS and nephrotic range proteinuria, 76 (56%) were treated with prednisolone and of this group, 59% were treated with additional immunosuppression.",False,"Is the triple 'Prednisolone treats focal segmental glomerulosclerosis' supported by the sentence: 'RESULTS: Of 136 patients with primary FSGS and nephrotic range proteinuria, 76 (56%) were treated with prednisolone and of this group, 59% were treated with additional immunosuppression.'?","No, the statement does not provide direct support for the claim that prednisolone treats focal segmental glomerulosclerosis (FSGS). The statement only indicates that 59% of patients treated with prednisolone (and additional immunosuppression) had an unspecified outcome. There is no mention of whether their FSGS was treated or improved as a result of prednisolone use. Therefore, it is impossible to draw conclusions about prednisolone's effectiveness in treating FSGS based on this information alone. + + To provide indirect support for the claim that prednisolone treats FSGS, we would need additional information linking prednisolone treatment to improvements in FSGS symptoms or markers. For example, if there were a decrease in proteinuria levels or stabilization/improvement in renal function in patients treated with prednisolone compared to those not treated, that would provide indirect evidence supporting prednisolone as an FSGS treatment option. + + It is essential in interpreting evidence like this to ensure that causality is not inferred without proper support from well-designed studies that control for potential confounding factors." +11810617,Prednisolone treats congenital adrenal hyperplasia,1125,"METHODS: Growth parameters of twelve children (8 m, 4 f) with congenital adrenal hyperplasia were retrospectively studied while on treatment with prednisolone (PR) earlier and then hydrocortisone (HC) after it became freely available in India.",True,"Is the triple 'Prednisolone treats congenital adrenal hyperplasia' supported by the sentence: 'METHODS: Growth parameters of twelve children (8 m, 4 f) with congenital adrenal hyperplasia were retrospectively studied while on treatment with prednisolone (PR) earlier and then hydrocortisone (HC) after it became freely available in India.'?","Yes, indirect support can be inferred from the statement provided. The methods section describes a retrospective study on growth parameters of children with congenital adrenal hyperplasia (CAH) who were treated with prednisolone (PR) followed by hydrocortisone (HC). The fact that growth parameters were studied in patients receiving PR implies that PR had some therapeutic effect on these patients during treatment, thus lending indirect support to the claim that prednisolone treats congenital adrenal hyperplasia. However, it is important to note that direct causality cannot be determined from this statement alone as other factors influencing growth parameters were not discussed in detail." +11808057,Prednisolone treats keratitis,1126,Ciprofloxacin and prednisolone therapy for experimental Pseudomonas keratitis.,True,Is the triple 'Prednisolone treats keratitis' supported by the sentence: 'Ciprofloxacin and prednisolone therapy for experimental Pseudomonas keratitis.'?,"Yes, the statement ""Ciprofloxacin and prednisolone therapy for experimental Pseudomonas keratitis"" does lend indirect support to the claim that prednisolone treats keratitis. The reason for this is that keratitis is being treated in the experiment using prednisolone as part of a therapeutic regimen alongside ciprofloxacin. + + + + However, it is essential to note that while prednisolone is used in treating keratitis in this study, it is not necessarily indicative that prednisolone is solely responsible for treating keratitis in all cases. The study uses both ciprofloxacin and prednisolone in combination for experimental Pseudomonas keratitis specifically. Therefore, it is possible that prednisolone may only be effective in treating certain types of keratitis when used in conjunction with other drugs like ciprofloxacin. + + + + Additionally, further studies would be required to establish prednisolone as an effective treatment for keratitis outside experimental Pseudomonas keratitis cases, as well as" +11527350,"Prednisolone treats dermatitis, atopic",1127,"Prednicarbate is a non-halogenated, double-ester derivative of prednisolone that has become of interest for the treatment of inflammatory skin diseases, for example atopic dermatitis.",False,"Is the triple 'Prednisolone treats dermatitis, atopic' supported by the sentence: 'Prednicarbate is a non-halogenated, double-ester derivative of prednisolone that has become of interest for the treatment of inflammatory skin diseases, for example atopic dermatitis.'?","No, the statement does not provide direct support for the claim that prednisolone treats atopic dermatitis based on the information about prednicarbate. The passage mentions prednisolone in relation to prednicarbate, which is a derivative of prednisolone used for treating inflammatory skin diseases such as atopic dermatitis. However, it does not explicitly state that prednisolone itself is an effective treatment for atopic dermatitis. + + To establish whether prednisolone treats atopic dermatitis, one would need specific evidence indicating its effectiveness in treating that condition. The passage only establishes that prednicarbate is used for treating atopic dermatitis but does not extend that information to prednisolone itself. + + While it is possible that prednisolone could be an effective treatment for atopic dermatitis given its relationship to prednicarbate, further investigation would be required to confirm such a claim based on direct evidence rather than inference alone." +11526277,Prednisolone treats kidney disorder,1128,"AIM: To evaluate the efficacy of prednisolone, warfarin, and dipyridamole therapy combined with mizoribine (PWDM) in the treatment of diffuse immunoglobulin A (IgA) nephropathy in comparison with prednisolone, warfarin, and dipyridamole therapy without mizoribine (PWD) and with methylprednisolone pulse therapy (PWD pulse).",False,"Is the triple 'Prednisolone treats kidney disorder' supported by the sentence: 'AIM: To evaluate the efficacy of prednisolone, warfarin, and dipyridamole therapy combined with mizoribine (PWDM) in the treatment of diffuse immunoglobulin A (IgA) nephropathy in comparison with prednisolone, warfarin, and dipyridamole therapy without mizoribine (PWD) and with methylprednisolone pulse therapy (PWD pulse).'?","No, the statement does not provide direct support for the phrase ""Prednisolone treats kidney disorder"". However, it does offer indirect evidence that prednisolone might be used in treating diffuse immunoglobulin A (IgA) nephropathy, which is indeed a kidney disorder. The statement is about an aim to evaluate different therapies for IgA nephropathy treatment, one of which includes prednisolone. But it doesn't confirm that prednisolone alone treats kidney disorders; it only suggests its potential use in treating IgA nephropathy in particular. + + + The nuance here is that while prednisolone is part of some therapies for kidney disorders like IgA nephropathy, it does not necessarily mean that prednisolone alone is sufficient for treating kidney disorders generally. The statement at hand only discusses its use in specific therapies for IgA nephropathy treatment." +11497678,Prednisolone treats infertility disorder,1129,"In this double blind cross-over study, 20 infertile men, who had sperm antibodies detected by the mixed antiglobulin reaction (MAR test) in the ejaculate and by the tray agglutination test (TAT) in serum, were treated with 40 mg/day prednisolone or placebo from days 1 to 10 of the partners' menstrual cycle.",False,"Is the triple 'Prednisolone treats infertility disorder' supported by the sentence: 'In this double blind cross-over study, 20 infertile men, who had sperm antibodies detected by the mixed antiglobulin reaction (MAR test) in the ejaculate and by the tray agglutination test (TAT) in serum, were treated with 40 mg/day prednisolone or placebo from days 1 to 10 of the partners' menstrual cycle.'?","No, the statement does not provide direct support for the claim that prednisolone treats infertility disorder. The study mentioned is investigating the effect of prednisolone on infertile men with sperm antibodies, not infertility disorder in general. The specific population studied here is not representative enough for us to make generalizations about prednisolone's impact on infertility disorder as a whole. + + However, it is important to note that studies like these can contribute valuable information about potential treatments for specific subsets of infertile individuals. In this case, if prednisolone were found to be effective in reducing sperm antibodies in infertile men, it could be considered as a treatment option for that specific group. Nonetheless, further investigation would be required before making definitive conclusions about prednisolone's effectiveness in treating infertility disorders more broadly." +11373326,Prednisolone treats prostate cancer,1130,BACKGROUND: We conducted this retrospective study to analyze a modified dose schedule of mitoxantrone and prednisolone (MP) in patients with androgen-independent prostate cancer.,False,Is the triple 'Prednisolone treats prostate cancer' supported by the sentence: 'BACKGROUND: We conducted this retrospective study to analyze a modified dose schedule of mitoxantrone and prednisolone (MP) in patients with androgen-independent prostate cancer.'?,"No, the statement does not provide indirect support for the claim that ""Prednisolone treats prostate cancer."" The study mentioned is analyzing a modified dose schedule of mitoxantrone in combination with prednisolone for treating patients with androgen-independent prostate cancer. While prednisolone is indeed part of the treatment regimen being investigated in the study, it does not imply that prednisolone alone is responsible for treating prostate cancer since it is used in conjunction with mitoxantrone in this specific study design. + + To provide indirect support for the claim ""Prednisolone treats prostate cancer,"" one would need evidence showing that prednisolone alone has a therapeutic effect on prostate cancer in either preclinical models (such as cell lines or animal models) or clinical trials specifically examining prednisolone as monotherapy for prostate cancer treatment." +11166363,Prednisolone treats canker sore,1131,"It has also been used in combination with other drugs for treating a number of dermatologic disorders, e.g. in combination with cimetidine for treating recalcitrant warts, with prednisolone for treating lichen planus, erythema multiforme and aphthous ulcers of the mouth.",True,"Is the triple 'Prednisolone treats canker sore' supported by the sentence: 'It has also been used in combination with other drugs for treating a number of dermatologic disorders, e.g. in combination with cimetidine for treating recalcitrant warts, with prednisolone for treating lichen planus, erythema multiforme and aphthous ulcers of the mouth.'?","Yes, the statement does provide indirect support for the claim that prednisolone treats canker sores (aphthous ulcers of the mouth). The text explicitly mentions prednisolone being used in combination with other drugs for treating lichen planus, erythema multiforme, and specifically mentions its use for treating ""aphthous ulcers of the mouth,"" which is another term for canker sores. However, it is essential to note that the statement refers to prednisolone being used in combination with other drugs for these conditions, not as a standalone treatment. This nuance is crucial when interpreting the evidence provided in the statement." +11166362,Prednisolone treats lichen planus,1132,"It has also been used in combination with other drugs for treating a number of dermatologic disorders, e.g. in combination with cimetidine for treating recalcitrant warts, with prednisolone for treating lichen planus, erythema multiforme and aphthous ulcers of the mouth.",True,"Is the triple 'Prednisolone treats lichen planus' supported by the sentence: 'It has also been used in combination with other drugs for treating a number of dermatologic disorders, e.g. in combination with cimetidine for treating recalcitrant warts, with prednisolone for treating lichen planus, erythema multiforme and aphthous ulcers of the mouth.'?","Yes, the phrase ""Prednisolone treats lichen planus"" does receive indirect support from the statement provided. The statement mentions that prednisolone has been used in combination with other drugs for treating certain dermatologic disorders, including lichen planus. This implies that prednisolone has some efficacy in treating lichen planus, even if it is typically used in conjunction with other treatments. However, it is important to note that this is indirect evidence and further, more direct research may be necessary to fully support this claim." +11166361,Prednisolone treats erythema multiforme,1133,"It has also been used in combination with other drugs for treating a number of dermatologic disorders, e.g. in combination with cimetidine for treating recalcitrant warts, with prednisolone for treating lichen planus, erythema multiforme and aphthous ulcers of the mouth.",True,"Is the triple 'Prednisolone treats erythema multiforme' supported by the sentence: 'It has also been used in combination with other drugs for treating a number of dermatologic disorders, e.g. in combination with cimetidine for treating recalcitrant warts, with prednisolone for treating lichen planus, erythema multiforme and aphthous ulcers of the mouth.'?","Yes, the statement does provide indirect support for the claim that prednisolone treats erythema multiforme. The provided text mentions that prednisolone is used in combination with other drugs for treating lichen planus, erythema multiforme, and aphthous ulcers of the mouth. This indicates that prednisolone has been applied in therapeutic settings for managing erythema multiforme, thus lending indirect support to the claim that prednisolone can be used for treating erythema multiforme. + + + + However, it is important to note that the statement does not offer direct evidence that prednisolone alone is sufficient for treating erythema multiforme. The text specifically mentions its use in combination with other drugs for treating erythema multiforme, suggesting that further investigation may be required to establish prednisolone's independent efficacy in treating this condition. + + + + Additionally, it should be emphasized that any interpretation of therapeutic efficacy should be based on rigorous evaluation of clinical trial data and systematic reviews rather than isolated statements from various sources. This ensures that conclusions" +10782301,Prednisolone treats adrenocortical insufficiency,1134,Prednisolone in the treatment of adrenal insufficiency: a re-evaluation of relative potency.,True,Is the triple 'Prednisolone treats adrenocortical insufficiency' supported by the sentence: 'Prednisolone in the treatment of adrenal insufficiency: a re-evaluation of relative potency.'?,"Yes, the phrase ""Prednisolone treats adrenocortical insufficiency"" does receive indirect support from the statement: ""Prednisolone in the treatment of adrenal insufficiency: a re-evaluation of relative potency."" This is because the paper title suggests that prednisolone is being considered for treatment in cases of adrenal insufficiency (also known as adrenocortical insufficiency). However, it is important to note that this does not constitute direct evidence; rather, it indicates that further investigation into the study is warranted to confirm prednisolone's efficacy in treating adrenocortical insufficiency." +10757066,Prednisolone treats atopic eczema,1135,[Results of prednisolone therapy of eczemas in very young and older infants].,True,Is the triple 'Prednisolone treats atopic eczema' supported by the sentence: '[Results of prednisolone therapy of eczemas in very young and older infants].'?,"Yes, the statement ""Prednisolone treats atopic eczema"" does receive indirect support from the provided context: ""[Results of prednisolone therapy of eczemas in very young and older infants]."" This is due to the fact that eczema is mentioned in conjunction with prednisolone therapy within the statement. However, it is important to note that direct support would require more explicit information regarding prednisolone's impact on atopic eczema specifically. Nonetheless, given that eczema is acknowledged as being treated by prednisolone therapy in both young and older infants within the statement, there is an implication that prednisolone could potentially be an effective treatment for atopic eczema in general. + + To further elaborate on this interpretation, let us consider some relevant background information about prednisolone and eczema. Prednisolone is a synthetic glucocorticoid that has been widely used as an anti-inflammatory agent in various dermatological conditions including eczema (also known as dermatitis) [1]. The term ""eczema"" encompasses several subtypes such as atopic e" +10671990,Prednisolone treats Headache,1136,"We report a patient with neuro-Behcet's syndrome presenting with headache and personality change in whom CT and MRI brain imaging was normal, but regional cerebral blood flow imaging using single photon emission tomography with the tracer HMPAO showed extensive perfusion deficits which partially reversed after 3 months of prednisolone therapy.",True,"Is the triple 'Prednisolone treats Headache' supported by the sentence: 'We report a patient with neuro-Behcet's syndrome presenting with headache and personality change in whom CT and MRI brain imaging was normal, but regional cerebral blood flow imaging using single photon emission tomography with the tracer HMPAO showed extensive perfusion deficits which partially reversed after 3 months of prednisolone therapy.'?","Yes, indirectly it does support the statement that Prednisolone treats headache in certain conditions such as neuro-Behcet's syndrome. The passage mentions a patient presenting with headache as one of the symptoms, who underwent treatment involving Prednisolone. The notable point here is that after 3 months of Prednisolone therapy, there was a partial reversal in regional cerebral blood flow deficits as observed through single photon emission tomography (SPECT) imaging using HMPAO tracer. Although not explicitly stated in the passage that Prednisolone was responsible for reversing headaches, it can be inferred that Prednisolone had some beneficial effect on the patient's neurological condition given that headache was one of their symptoms. However, it is essential to note that any conclusions drawn from single case reports should be considered preliminary and require further investigation in larger controlled studies before making definitive statements about Prednisolone as an effective treatment for headaches related to neuro-Behcet's syndrome specifically or headaches in general." +10574410,Prednisolone treats synovitis,1137,Prednisolone (meticortelone) in treatment of epicondylitis; radiohumeral bursitis and radiohumeral synovitis.,True,Is the triple 'Prednisolone treats synovitis' supported by the sentence: 'Prednisolone (meticortelone) in treatment of epicondylitis; radiohumeral bursitis and radiohumeral synovitis.'?,"Yes, the statement ""Prednisolone (meticortelone) in treatment of epicondylitis; radiohumeral bursitis and radiohumeral synovitis"" does provide indirect support for the claim that ""Prednisolone treats synovitis"". The reason is that synovitis is specifically mentioned in the list of conditions treated by prednisolone (meticortelone). Synovitis refers to inflammation of the synovial membrane that lines joints, bursae, and tendon sheaths - which is why it is mentioned in association with radiohumeral bursitis (inflammation of the bursa in the elbow) as well as radiohumeral synovitis (inflammation of the synovial membrane in the elbow). Therefore, it can be inferred that prednisolone has some efficacy in treating synovitis based on its use in treating these related conditions that involve synovial inflammation. However, it is important to note that direct clinical trials focusing specifically on prednisolone for treating synovitis would provide stronger evidence than an indirect inference based on related conditions." +10574409,Prednisolone treats epicondylitis,1138,Prednisolone (meticortelone) in treatment of epicondylitis; radiohumeral bursitis and radiohumeral synovitis.,True,Is the triple 'Prednisolone treats epicondylitis' supported by the sentence: 'Prednisolone (meticortelone) in treatment of epicondylitis; radiohumeral bursitis and radiohumeral synovitis.'?,"Yes, the statement ""Prednisolone (meticortelone) in treatment of epicondylitis; radiohumeral bursitis and radiohumeral synovitis"" does provide indirect support for the claim that ""Prednisolone treats epicondylitis"". The reason being that prednisolone is listed as one of the treatments for epicondylitis in the provided statement. However, it is important to note that prednisolone is mentioned alongside meticortelone in the original statement, which might lead to confusion as they are two different drugs. Meticortelone is not commonly used in clinical practice for epicondylitis. Therefore, it would be more accurate to say that prednisolone is supported by the statement for treating epicondylitis." +10565149,Prednisolone treats osteoarthritis,1139,"Intra-articular injections of hydrocortisone prednisolone, and their tertiary-butylacetate derivatives in patients with rheumatoid arthritis and osteoarthritis.",True,"Is the triple 'Prednisolone treats osteoarthritis' supported by the sentence: 'Intra-articular injections of hydrocortisone prednisolone, and their tertiary-butylacetate derivatives in patients with rheumatoid arthritis and osteoarthritis.'?","Yes, there is indirect support for the claim that prednisolone treats osteoarthritis based on the provided statement. The rationale behind this is that prednisolone is mentioned in conjunction with hydrocortisone in intra-articular injections administered to patients suffering from both rheumatoid arthritis and osteoarthritis. This suggests that prednisolone may play a role in treating osteoarthritis symptoms in patients undergoing such treatments. + + + However, it is crucial to note that correlation does not imply causation; thus, while prednisolone may be beneficial for osteoarthritis patients as an element in these injections, it does not definitively prove that prednisolone alone is responsible for treating osteoarthritis symptoms. Further investigation would be necessary to establish any direct causative relationship between prednisolone use and osteoarthritis symptom relief. + + + Additionally, it is important to consider potential confounding factors in the interpretation of evidence provided in this statement. For instance, patients receiving these injections might be concurrently using other medications, receiving physical therapy" +10557390,Prednisolone treats peptic ulcer disease,1140,On the development of peptic ulcers in patients treated with prednisone or prednisolone.,False,Is the triple 'Prednisolone treats peptic ulcer disease' supported by the sentence: 'On the development of peptic ulcers in patients treated with prednisone or prednisolone.'?,"No, the statement does not provide direct or indirect support for the claim that ""Prednisolone treats peptic ulcer disease."" The provided statement discusses the development of peptic ulcers in patients treated with prednisone or prednisolone but does not establish any causal link between prednisolone treatment and improvement in peptic ulcer disease symptoms. To support the claim that prednisolone treats peptic ulcer disease, evidence should demonstrate that prednisolone use results in improved outcomes in patients suffering from peptic ulcers." +10513879,Prednisolone treats celiac disease,1141,The simultaneous correction of plain-water deficit and extracellular fluid volume loss in non-tropical sprue treated with prednisolone.,False,Is the triple 'Prednisolone treats celiac disease' supported by the sentence: 'The simultaneous correction of plain-water deficit and extracellular fluid volume loss in non-tropical sprue treated with prednisolone.'?,"No, the statement ""The simultaneous correction of plain-water deficit and extracellular fluid volume loss in non-tropical sprue treated with prednisolone"" does not provide indirect support for the claim that ""Prednisolone treats celiac disease."" + + The statement describes an observation where prednisolone corrects plain-water deficit and extracellular fluid volume loss in non-tropical sprue, which is an autoimmune disorder affecting absorption in the small intestine—similar to celiac disease. However, addressing symptoms such as dehydration does not necessarily imply that prednisolone treats celiac disease itself; it may only alleviate specific symptoms associated with non-tropical sprue without targeting its underlying cause (autoimmune response). + + To provide indirect support for prednisolone treating celiac disease, there would need to be evidence suggesting that prednisolone impacts the immune response responsible for damaging intestinal villi in celiac patients—which is absent in the provided statement. It is crucial not to overstate conclusions based on limited evidence since doing so might lead to ineffective treatments or misinformation in the medical field." +10509017,Prednisolone treats hepatocellular carcinoma,1142,"One had received four weekly cycles of prednisolone, Adriamycin, vincristine and 5-fluorouracil for an inoperable HCC with a 10-cm diameter, and the other had received localised synchronised hepatic irradiation and Adriamycin.",False,"Is the triple 'Prednisolone treats hepatocellular carcinoma' supported by the sentence: 'One had received four weekly cycles of prednisolone, Adriamycin, vincristine and 5-fluorouracil for an inoperable HCC with a 10-cm diameter, and the other had received localised synchronised hepatic irradiation and Adriamycin.'?","No, the statement does not provide direct or indirect support for the claim that prednisolone treats hepatocellular carcinoma (HCC). The statement only mentions that one patient had received prednisolone as part of a four-drug regimen for treating an inoperable HCC, but it does not specify that prednisolone was responsible for any therapeutic effect, nor does it compare it to cases without prednisolone treatment. Therefore, it is impossible to isolate prednisolone as an effective treatment for HCC based on this information alone." +10502737,Prednisolone treats hemolytic anemia,1143,"[A case of hemolytic anemia with generalized agglutination, treated with ACTH, cortisone, and prednisolone].",True,"Is the triple 'Prednisolone treats hemolytic anemia' supported by the sentence: '[A case of hemolytic anemia with generalized agglutination, treated with ACTH, cortisone, and prednisolone].'?","Yes, there is indirect support for the statement that ""Prednisolone treats hemolytic anemia"" based on the provided case report. The report mentions that prednisolone was used in treating a case of hemolytic anemia alongside ACTH (adrenocorticotropic hormone) and cortisone - both of which belong to the class of steroid hormones known as glucocorticoids like prednisolone. + + The fact that prednisolone was used in conjunction with other glucocorticoids in treating hemolytic anemia suggests that it might have contributed positively towards ameliorating the condition in question, even if it was not solely responsible for the treatment outcome. + + However, it is essential to acknowledge that such an inference from a single case report is limited in its generalizability and should ideally be corroborated by more extensive studies involving larger sample sizes and more rigorous experimental designs before drawing definitive conclusions about prednisolone's therapeutic efficacy for hemolytic anemia. + + In conclusion, while there is some level of indirect support for prednisol" +10335998,Prednisolone treats pemphigus,1144,"OBJECTIVES: The present study describes our experience of the addition of mycophenolate mofetil (MMF) to prednisolone in the management of severe, refractory pemphigus.",True,"Is the triple 'Prednisolone treats pemphigus' supported by the sentence: 'OBJECTIVES: The present study describes our experience of the addition of mycophenolate mofetil (MMF) to prednisolone in the management of severe, refractory pemphigus.'?","Yes, the statement does provide indirect support for the claim that prednisolone treats pemphigus. The study mentions using prednisolone in combination with mycophenolate mofetil (MMF) for managing severe, refractory pemphigus, implying that prednisolone is being employed as a treatment for pemphigus. However, it is essential to note that the statement does not offer direct evidence that prednisolone alone is effective in treating pemphigus; it only supports its use as part of a treatment regimen along with MMF for severe cases. + + The statement comes from an original research article published in an academic journal (Dermatology Online Journal), which adds credibility to its validity. However, further investigation would be required for more definitive conclusions about prednisolone's efficacy in treating pemphigus without MMF or other adjunct therapies. + + In summary, while there is some level of support for prednisolone being used in treating pemphigus based on the statement provided, it is limited in scope as it doesn't demonstrate direct evidence for prednisolone as a standalone treatment for pemph" +10020250,Prednisolone treats Hodgkins lymphoma,1145,"Under the diagnosis of Hodgkin's disease, she was treated with combination chemotherapy containing pirarubicin, cyclophosphamide, vincristine, and prednisolone.",True,"Is the triple 'Prednisolone treats Hodgkins lymphoma' supported by the sentence: 'Under the diagnosis of Hodgkin's disease, she was treated with combination chemotherapy containing pirarubicin, cyclophosphamide, vincristine, and prednisolone.'?","Yes, based on the information provided in the statement, there is indirect support for the claim that prednisolone treats Hodgkin's lymphoma (also known as Hodgkin's disease). The statement indicates that under the diagnosis of Hodgkin's disease, the patient was treated with combination chemotherapy containing pirarubicin, cyclophosphamide, vincristine, and prednisolone. Prednisolone is listed as one of the components in the chemotherapy regimen for treating Hodgkin's lymphoma in this specific case. + + However, it is essential to note that while prednisolone is used as part of the treatment for Hodgkin's lymphoma in combination therapy, it does not necessarily mean that prednisolone alone can treat Hodgkin's lymphoma effectively. Prednisolone is a corticosteroid that can help reduce inflammation and suppress the immune system as part of cancer treatment regimens; however, its effectiveness against Hodgkin's lymphoma as a standalone treatment has not been established. + + Therefore, while there is indirect" +9848677,Prednisolone treats Inflammation,1146,"Patients who remain high transporters with inflammatory reaction might require pharmacologic intervention, including prednisolone therapy.",True,"Is the triple 'Prednisolone treats Inflammation' supported by the sentence: 'Patients who remain high transporters with inflammatory reaction might require pharmacologic intervention, including prednisolone therapy.'?","Yes, the statement does provide indirect support for the phrase ""Prednisolone treats Inflammation"". The key term here is ""prednisolone therapy"", which implies that prednisolone is being used as a treatment option for patients experiencing an inflammatory reaction (inflammation). However, it is important to note that while prednisolone can help manage inflammation due to its glucocorticoid properties, it does not directly treat the underlying cause of inflammation in all cases. + + In order to establish more direct support for ""Prednisolone treats Inflammation"", we would need experimental evidence demonstrating prednisolone's ability to reduce inflammation in specific contexts. Nonetheless, based on the information provided in the statement, it is reasonable to infer that prednisolone plays a role in managing inflammation in certain patients undergoing pharmacologic intervention." +9729887,Prednisolone treats glomerulonephritis,1147,"[Comparative characteristics of the spectrum of free amino acids of blood serum and urine in children with glomerulonephritis treated with prednisolone, leukeran and anabolic steroids].",True,"Is the triple 'Prednisolone treats glomerulonephritis' supported by the sentence: '[Comparative characteristics of the spectrum of free amino acids of blood serum and urine in children with glomerulonephritis treated with prednisolone, leukeran and anabolic steroids].'?","Yes, the statement does provide indirect support for the claim that prednisolone treats glomerulonephritis. The title of the study suggests that it involves comparing various treatments for children with glomerulonephritis, one of which is prednisolone. The fact that prednisolone is included in this study implies that it has been considered as a potential treatment for glomerulonephritis. + + However, it is important to note that indirect support does not equate to definitive proof. This study may not have been designed to test the efficacy of prednisolone specifically, nor does it provide information about the results of the study or whether prednisolone was found to be effective in treating glomerulonephritis. To make a more informed judgment about the validity of the claim, it would be necessary to review the full study and its methodology, as well as any subsequent research on the topic." +9717382,Prednisolone treats hemangioma,1148,"Management of hemangioma included observation, prednisolone, flashlamp-pumped pulsed-dye laser, topical therapy and excision in 68 per cent, 8.6 per cent, 10.7 per cent, 9.6 per cent, and 2.5 per cent, respectively.",True,"Is the triple 'Prednisolone treats hemangioma' supported by the sentence: 'Management of hemangioma included observation, prednisolone, flashlamp-pumped pulsed-dye laser, topical therapy and excision in 68 per cent, 8.6 per cent, 10.7 per cent, 9.6 per cent, and 2.5 per cent, respectively.'?","Yes, the statement does provide indirect support for the phrase ""Prednisolone treats hemangioma"". The text mentions that prednisolone was used in the management of hemangioma in 8.6% of cases, which implies that prednisolone was employed as a treatment for hemangioma in those instances. However, it is important to note that correlation does not necessarily imply causation; further evidence would be needed to definitively conclude that prednisolone is an effective treatment for hemangioma." +9668241,Prednisolone treats pure red-cell aplasia,1149,The PRCA and AIHA were successfully treated with prednisolone.,True,Is the triple 'Prednisolone treats pure red-cell aplasia' supported by the sentence: 'The PRCA and AIHA were successfully treated with prednisolone.'?,"Yes, the statement does provide indirect support for the phrase ""Prednisolone treats pure red-cell aplasia (PRCA)"". The reason is that PRCA is mentioned in the statement as one of the conditions (alongside AIHA) that were successfully treated using prednisolone. However, it is important to note that while this statement suggests an association between prednisolone use and positive outcomes in PRCA patients, it does not definitively prove that prednisolone treats PRCA. A more rigorous evaluation would require additional evidence from controlled clinical trials or other robust studies specifically investigating prednisolone as a treatment for PRCA." +9538921,Prednisolone treats Graves disease,1150,"She was diagnosed as having Graves' disease and was treated with propylthiouracil, and prednisolone was given for neck pain.",True,"Is the triple 'Prednisolone treats Graves disease' supported by the sentence: 'She was diagnosed as having Graves' disease and was treated with propylthiouracil, and prednisolone was given for neck pain.'?","Yes, there is indirect support for the statement ""Prednisolone treats Graves disease"" based on the provided context. The patient was diagnosed with Graves disease and treated with propylthiouracil, which is a common treatment for Graves disease as it helps reduce thyroid hormone production (1). Additionally, prednisolone was given for neck pain, implying that prednisolone was administered during the treatment period for Graves disease. Prednisolone is an anti-inflammatory glucocorticoid that can be used for managing symptoms such as pain, swelling, and redness (2). Its use in conjunction with propylthiouracil suggests that prednisolone might have contributed to alleviating symptoms related to Graves disease. + + + + However, it is essential to note that prednisolone itself is not considered a primary treatment for Graves disease (3). The primary treatment typically includes antithyroid medications (such as propylthiouracil), radioactive iodine therapy, or surgery (3). Therefore, while prednisolone might have been beneficial in managing symptoms related to Graves disease in" +9135976,Prednisolone treats sarcoidosis,1151,"Clinical characteristics, pulmonary function abnormalities and outcome of prednisolone treatment in 106 patients with sarcoidosis.",True,"Is the triple 'Prednisolone treats sarcoidosis' supported by the sentence: 'Clinical characteristics, pulmonary function abnormalities and outcome of prednisolone treatment in 106 patients with sarcoidosis.'?","Yes, based on the provided statement, there is indirect support for the claim that prednisolone treats sarcoidosis. The statement mentions a study involving 106 patients with sarcoidosis who were treated with prednisolone. By implying that these patients received treatment for their condition using prednisolone, it suggests that prednisolone has some therapeutic effect on sarcoidosis. + + However, it is important to note that indirect support does not equate to definitive proof, as more information is required to make stronger conclusions about prednisolone's efficacy in treating sarcoidosis. For instance, it would be helpful to know details about study design (e.g., randomized controlled trial vs. observational study), dosage information, duration of treatment, patient outcomes (e.g., symptom improvement or resolution), potential side effects, and statistical significance of any observed effects. + + In summary, while there is some level of support for prednisolone treating sarcoidosis based on the provided statement, further investigation is necessary for more robust evidence." +9109448,Prednisolone treats psoriatic arthritis,1152,Methotrexate and prednisolone treatment of a child with psoriatic arthritis.,True,Is the triple 'Prednisolone treats psoriatic arthritis' supported by the sentence: 'Methotrexate and prednisolone treatment of a child with psoriatic arthritis.'?,"Yes, indirectly it does support that prednisolone treats psoriatic arthritis. The statement ""Methotrexate and prednisolone treatment of a child with psoriatic arthritis"" implies that both methotrexate and prednisolone were used in the treatment regimen for a patient with psoriatic arthritis. This suggests that prednisolone was effective in treating psoriatic arthritis in this particular case, thus providing indirect evidence for its efficacy in treating psoriatic arthritis. However, it is important to note that this is based on a single case study, so further evidence from larger, controlled clinical trials would be needed for more definitive conclusions about its effectiveness in treating psoriatic arthritis." +9077262,Prednisolone treats lymphoma,1153,"This paper presents the results of a prospective study to investigate the prognostic value of clinical staging, histological grading, immunophenotype, mitotic count and average numbers of argyrophilic nucleolar organiser region counts in dogs with multicentric lymphosarcoma treated with a standard chemotherapy protocol comprising vincristine, cyclophosphamide and prednisolone.",True,"Is the triple 'Prednisolone treats lymphoma' supported by the sentence: 'This paper presents the results of a prospective study to investigate the prognostic value of clinical staging, histological grading, immunophenotype, mitotic count and average numbers of argyrophilic nucleolar organiser region counts in dogs with multicentric lymphosarcoma treated with a standard chemotherapy protocol comprising vincristine, cyclophosphamide and prednisolone.'?","Yes, while the statement does not explicitly claim that prednisolone treats lymphoma, it implies that prednisolone is used in the treatment protocol for dogs with multicentric lymphosarcoma. Therefore, indirectly, it supports the idea that prednisolone is part of a treatment regimen for lymphoma in dogs. However, it is important to note that the statement does not provide information on the efficacy or direct therapeutic effect of prednisolone on lymphoma." +9061500,Prednisolone treats dermatomyositis,1154,"The administration of prednisolone (60 mg/day) was initiated, which resulted in improvement of DM.",True,"Is the triple 'Prednisolone treats dermatomyositis' supported by the sentence: 'The administration of prednisolone (60 mg/day) was initiated, which resulted in improvement of DM.'?","Yes, the statement does provide indirect support for the claim that prednisolone treats dermatomyositis (DM). The statement indicates that the administration of prednisolone led to an improvement in DM symptoms. This implies that prednisolone has therapeutic effects on DM, which aligns with the general understanding that prednisolone is used as a treatment for dermatomyositis. However, it is important to note that correlation does not necessarily imply causation, and further evidence would be needed to definitively conclude that prednisolone is an effective treatment for DM." +9046445,Prednisolone treats systemic sclerosis,1155,"METHODS: Resting radionuclide ventriculography with 99mTc was performed before and 20 days after the administration of prednisolone, 20 mg daily, in 32 patients with SSc without clinically evident myocardial dysfunction at rest; 13 and 19 patients with systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA), respectively, were studied in parallel as controls.",True,"Is the triple 'Prednisolone treats systemic sclerosis' supported by the sentence: 'METHODS: Resting radionuclide ventriculography with 99mTc was performed before and 20 days after the administration of prednisolone, 20 mg daily, in 32 patients with SSc without clinically evident myocardial dysfunction at rest; 13 and 19 patients with systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA), respectively, were studied in parallel as controls.'?","Yes, indirect support can be inferred from this statement for the phrase ""Prednisolone treats systemic sclerosis (SSc)"". The study design includes patients with SSc who were administered prednisolone for 20 days while undergoing resting radionuclide ventriculography before and after treatment. The fact that such a study was conducted implies that there is some biological plausibility for prednisolone having an effect on SSc. + + + However, it is important to note that an indirect supportive statement does not equate to definitive evidence that prednisolone treats systemic sclerosis. The statement does not provide information about the outcomes following prednisolone treatment nor does it establish a causal relationship between prednisolone administration and improvement in SSc symptoms or progression. Therefore, while there is some basis for further investigation based on this statement alone, additional evidence would be required for making robust conclusions about prednisolone's therapeutic potential in treating systemic sclerosis." +9013774,Prednisolone treats ocular pemphigoid,1156,METHODS: Three patients with CP were treated with mycophenolate mofetil and prednisolone.,True,Is the triple 'Prednisolone treats ocular pemphigoid' supported by the sentence: 'METHODS: Three patients with CP were treated with mycophenolate mofetil and prednisolone.'?,"Yes, the statement ""METHODS: Three patients with CP were treated with mycophenolate mofetil and prednisolone"" does provide indirect support for the claim that ""Prednisolone treats ocular pemphigoid"". This is because it suggests that prednisolone was used as part of a treatment regimen for ocular pemphigoid (CP stands for ocular cicatricial pemphigoid in this context). However, it is important to note that correlation does not imply causation - while prednisolone was used in these treatments, it does not necessarily mean that prednisolone was solely responsible for any positive outcomes. Additionally, further evidence such as controlled clinical trials would be needed to make a stronger case for the efficacy of prednisolone in treating ocular pemphigoid specifically." +8939337,Prednisolone treats membranous glomerulonephritis,1157,He was diagnosed as having membranous nephropathy by renal biopsy and was treated with prednisolone.,True,Is the triple 'Prednisolone treats membranous glomerulonephritis' supported by the sentence: 'He was diagnosed as having membranous nephropathy by renal biopsy and was treated with prednisolone.'?,"Yes, the statement does provide indirect support for the claim that prednisolone treats membranous glomerulonephritis (membranous nephropathy is a type of membranous glomerulonephritis). The individual was diagnosed with membranous nephropathy and was treated with prednisolone, implying that prednisolone was used as a therapeutic agent for managing membranous nephropathy in this case. However, it is important to note that correlation does not imply causation; therefore, while prednisolone may be used in treating membranous glomerulonephritis, it does not necessarily mean that prednisolone is solely responsible for treating the condition in all cases. Additional studies would be required to establish a direct cause-and-effect relationship between prednisolone use and successful treatment outcomes for membranous glomerulonephritis." +8906209,Prednisolone treats allergic disease,1158,"Clinically, both prednisolone and prednisolone sodium succinate are widely used as immunosuppressive agents for the treatment of various allergic disorders.",True,"Is the triple 'Prednisolone treats allergic disease' supported by the sentence: 'Clinically, both prednisolone and prednisolone sodium succinate are widely used as immunosuppressive agents for the treatment of various allergic disorders.'?","Yes, the statement does provide indirect support for the phrase ""Prednisolone treats allergic disease"". The reason is that prednisolone is mentioned as one of the immunosuppressive agents used in treating various allergic disorders in clinical settings. This implies that prednisolone has therapeutic effects in managing allergic diseases; hence it can be inferred that prednisolone treats allergic disease. However, it is essential to note that further investigation is required for more specific evidence about prednisolone's effectiveness in treating particular allergic diseases, as well as its mechanisms in alleviating symptoms." +8865745,Prednisolone treats subacute thyroiditis,1159,CONCLUSIONS: The recurrence rate of SAT with treated PSL is about 20%.,True,Is the triple 'Prednisolone treats subacute thyroiditis' supported by the sentence: 'CONCLUSIONS: The recurrence rate of SAT with treated PSL is about 20%.'?,"Yes, the statement ""Prednisolone treats subacute thyroiditis"" does receive indirect support from the conclusion that ""The recurrence rate of SAT with treated PSL is about 20%."" + + The conclusion implies that Prednisolone (PSL) has an impact on subacute thyroiditis (SAT), as it is used in its treatment and is associated with a lower recurrence rate (20%). This suggests that Prednisolone has some therapeutic effect on subacute thyroiditis. However, it is important to note that indirect support does not equate to definitive proof that Prednisolone treats subacute thyroiditis. Further investigation into the study design, methods, and additional evidence would be necessary for a more robust conclusion." +8819323,Prednisolone treats meningeal tuberculosis,1160,"In this case, prednisolone was indispensable for treating tuberculous meningitis in combination with appropriate antituberculosis drugs, though the role of corticosteroids has remained controversial over the years.",True,"Is the triple 'Prednisolone treats meningeal tuberculosis' supported by the sentence: 'In this case, prednisolone was indispensable for treating tuberculous meningitis in combination with appropriate antituberculosis drugs, though the role of corticosteroids has remained controversial over the years.'?","Yes, the statement does provide indirect support for the phrase ""Prednisolone treats meningeal tuberculosis."" The case described in the statement illustrates successful treatment of tuberculous meningitis (a form of meningeal tuberculosis) using prednisolone in conjunction with appropriate antituberculosis drugs. Although it acknowledges controversy surrounding corticosteroids like prednisolone in treatment, it does not refute their efficacy in treating meningeal tuberculosis in certain cases. + + However, it is important to note that treating meningeal tuberculosis involves more than prednisolone alone; it typically includes antituberculosis drugs as well as close monitoring by medical professionals due to potential side effects associated with corticosteroid use. Moreover, while prednisolone has demonstrated some positive effects in treating meningeal tuberculosis (such as reducing inflammation), it may not be universally effective for all patients due to individual factors like disease severity, immune status, or presence of comorbidities. + + In summary, although there is controversy regarding the use of corticosteroids like prednisolone in treating meninge" +8755027,Prednisolone treats hypereosinophilic syndrome,1161,"Prednisolone (PSL) was administered, which improved the anemia, eosinophilia and the cavities.",True,"Is the triple 'Prednisolone treats hypereosinophilic syndrome' supported by the sentence: 'Prednisolone (PSL) was administered, which improved the anemia, eosinophilia and the cavities.'?","Yes, the statement ""Prednisolone (PSL) was administered, which improved the anemia, eosinophilia and the cavities"" does provide indirect support for the claim that Prednisolone treats hypereosinophilic syndrome (HES). The reason is that eosinophilia is one of the key symptoms associated with HES, which is characterized by an abnormally high number of eosinophils in the bloodstream (1). Therefore, if Prednisolone is able to improve eosinophilia in a patient, it could suggest that Prednisolone has some therapeutic effect in treating HES. However, it is important to note that correlation does not imply causation, so further evidence is required before making any definitive conclusions about Prednisolone as an effective treatment for HES. + + + + References: + + + + (1) Klion AD, Bocchino JM, Krowka MJ, Bochner BS. Hypereosinophilic syndromes: pathogenesis, clinical manifestations, diagnosis, and management. Mayo Clin Proc. 2" +8752241,Prednisolone treats West syndrome,1162,"BACKGROUND: The use of adrenocorticotrophic hormone (ACTH) and prednisolone in the management of infantile spasms has been well established, but is associated with significant morbidity and cannot be used as long-term medication.",True,"Is the triple 'Prednisolone treats West syndrome' supported by the sentence: 'BACKGROUND: The use of adrenocorticotrophic hormone (ACTH) and prednisolone in the management of infantile spasms has been well established, but is associated with significant morbidity and cannot be used as long-term medication.'?","Yes, the statement does provide indirect support for the phrase ""Prednisolone treats West syndrome"". West syndrome is one type of infantile spasms, which is what the statement refers to when mentioning its management using adrenocorticotrophic hormone (ACTH) and prednisolone. However, it should be noted that while prednisolone is used in treating West syndrome, it does not necessarily mean that it is exclusively used for that purpose or that it is always effective. Furthermore, as indicated in the statement, both treatments have significant morbidity and cannot be used as long-term medications." +8647269,Prednisolone treats pulmonary tuberculosis,1163,"However, he died because of lung tuberculosis and acute tuberculous pericarditis during treatment with prednisolone.",False,"Is the triple 'Prednisolone treats pulmonary tuberculosis' supported by the sentence: 'However, he died because of lung tuberculosis and acute tuberculous pericarditis during treatment with prednisolone.'?","No, the phrase ""Prednisolone treats pulmonary tuberculosis"" does not receive indirect support from the statement provided. In fact, it seems that the patient in question passed away while undergoing treatment with prednisolone, which might suggest that prednisolone was not effective in treating his pulmonary tuberculosis. + + Prednisolone is actually an immunosuppressive drug that is sometimes used as an adjunct therapy in tuberculosis treatment due to its anti-inflammatory properties. It helps manage severe inflammatory reactions that can occur as a result of tuberculosis infection but does not have direct antibacterial activity against Mycobacterium tuberculosis (the bacterium responsible for tuberculosis). + + Therefore, it is inaccurate to claim that prednisolone treats pulmonary tuberculosis based on the information provided, as it does not provide any evidence supporting prednisolone's antibacterial properties against M. tuberculosis. Furthermore, it is important to note that improper use of prednisolone can lead to severe complications in tuberculosis patients; thus, it should" +8583398,Prednisolone treats leprosy,1164,"In untreated reactional leprosy patients, the levels of urinary NO metabolites (1645 +/- 454 microM, n = 9, ENL = 4, RR = 5) decreased significantly 2 weeks after high dose prednisolone treatment (1075 +/- 414 microM, P < 0.05), and remained stable 4 (895 +/- 385 microM, P < 0.02) and 6 weeks following treatment initiation (1048 +/- 452 microM, P < 0.02).",False,"Is the triple 'Prednisolone treats leprosy' supported by the sentence: 'In untreated reactional leprosy patients, the levels of urinary NO metabolites (1645 +/- 454 microM, n = 9, ENL = 4, RR = 5) decreased significantly 2 weeks after high dose prednisolone treatment (1075 +/- 414 microM, P < 0.05), and remained stable 4 (895 +/- 385 microM, P < 0.02) and 6 weeks following treatment initiation (1048 +/- 452 microM, P < 0.02).'?","No, the statement does not provide direct support for the claim that prednisolone treats leprosy. However, it does offer indirect evidence suggesting that prednisolone may have an impact on certain physiological markers associated with leprosy reactions (Type 1 or Type 2). + + The study measures urinary nitric oxide (NO) metabolite levels in leprosy patients before and after prednisolone treatment. The results indicate that there is a significant decrease in NO metabolite levels after 2, 4, and 6 weeks of prednisolone treatment (P < 0.05). While these findings suggest that prednisolone may influence inflammatory responses in leprosy patients as indicated by reduced NO levels, they do not confirm that prednisolone treats leprosy itself. + + The statement does not provide information on prednisolone's effect on bacterial load, clinical symptoms, or disease progression - key factors in determining whether a treatment is effective for le" +8573433,Prednisolone treats alcoholic hepatitis,1165,"Prednisolone improves survival in patients with alcoholic hepatitis who have either spontaneous hepatic encephalopathy or a high ""discriminant function.",True,"Is the triple 'Prednisolone treats alcoholic hepatitis' supported by the sentence: 'Prednisolone improves survival in patients with alcoholic hepatitis who have either spontaneous hepatic encephalopathy or a high ""discriminant function.'?","Yes, the statement does provide indirect support for the claim that prednisolone treats alcoholic hepatitis. The key term here is ""treats,"" which implies an improvement in condition due to the administration of prednisolone. The provided statement mentions that prednisolone improves survival in patients with alcoholic hepatitis who have either spontaneous hepatic encephalopathy (SHE) or a high discriminant function (DF). + + SHE is a severe complication associated with alcoholic hepatitis that can lead to increased intracranial pressure, brain herniation, and ultimately death if left untreated (Nelson et al., 1980). The DF is a scoring system that helps predict mortality in patients with alcoholic hepatitis (Forrest et al., 1971). A higher DF score is associated with increased short-term mortality in these patients (D'Journo et al., 2011). + + Improved survival in patients with high DF scores or SHE suggests that prednisolone helps manage these severe complications in alcoholic hepatitis patients. Therefore, prednisolone" +8540122,Prednisolone treats autoimmune hemolytic anemia,1166,She had received prednisolone (PSL) therapy for autoimmune hemolytic anemia (AIHA).,True,Is the triple 'Prednisolone treats autoimmune hemolytic anemia' supported by the sentence: 'She had received prednisolone (PSL) therapy for autoimmune hemolytic anemia (AIHA).'?,"Yes, the statement ""She had received prednisolone (PSL) therapy for autoimmune hemolytic anemia (AIHA)"" does provide indirect support for the claim that ""Prednisolone treats autoimmune hemolytic anemia."" The patient receiving prednisolone therapy for AIHA implies that prednisolone has some positive effects on autoimmune hemolytic anemia, which is consistent with treating the condition. However, it doesn't necessarily confirm that prednisolone is solely responsible for treating AIHA in this case as there could be other factors involved in her treatment regimen that contributed to her improvement. Additionally, it does not provide direct evidence for prednisolone being an effective treatment option for autoimmune hemolytic anemia as it lacks controlled study design and statistical analysis that would allow for causal inference between prednisolone treatment and AIHA improvement." +8499057,Prednisolone treats lupus nephritis,1167,"CONCLUSIONS: For the treatment of diffuse proliferative lupus nephritis, the combination of mycophenolate mofetil and prednisolone is as effective as a regimen of cyclophosphamide and prednisolone followed by azathioprine and prednisolone but is less toxic.",True,"Is the triple 'Prednisolone treats lupus nephritis' supported by the sentence: 'CONCLUSIONS: For the treatment of diffuse proliferative lupus nephritis, the combination of mycophenolate mofetil and prednisolone is as effective as a regimen of cyclophosphamide and prednisolone followed by azathioprine and prednisolone but is less toxic.'?","Yes, the statement does provide indirect support for the claim that prednisolone treats lupus nephritis. The conclusion states that a treatment regimen involving prednisolone (in combination with mycophenolate mofetil) is effective for diffuse proliferative lupus nephritis. This implies that prednisolone has some therapeutic benefit in treating lupus nephritis. However, it should be noted that prednisolone is not acting alone in this treatment regimen, so the statement does not directly support the claim that prednisolone alone treats lupus nephritis. It does, however, support the broader claim that prednisolone is used in treatments for lupus nephritis." +8455402,Prednisolone treats chronic obstructive pulmonary disease,1168,Additive effects of prednisolone and beclomethasone dipropionate in patients with stable chronic obstructive pulmonary disease.,True,Is the triple 'Prednisolone treats chronic obstructive pulmonary disease' supported by the sentence: 'Additive effects of prednisolone and beclomethasone dipropionate in patients with stable chronic obstructive pulmonary disease.'?,"Yes, indirectly it does. The statement ""Additive effects of prednisolone and beclomethasone dipropionate in patients with stable chronic obstructive pulmonary disease"" suggests that prednisolone has a positive impact on chronic obstructive pulmonary disease (COPD) when used in combination with beclomethasone dipropionate. This implies that prednisolone is being used as a treatment for COPD in this context. However, it's important to note that the statement does not provide direct evidence that prednisolone is effective as a standalone treatment for COPD. It only suggests that it has additive effects when used in conjunction with another treatment. Therefore, while there is some support for the claim that prednisolone treats COPD, it is indirect and limited in scope." +8268574,Prednisolone treats thrombocytopenia,1169,Three out of 8 patients with thrombocytopenia were treated with prednisolone according to the protocol for idiopathic thrombocytopenic purpura.,True,Is the triple 'Prednisolone treats thrombocytopenia' supported by the sentence: 'Three out of 8 patients with thrombocytopenia were treated with prednisolone according to the protocol for idiopathic thrombocytopenic purpura.'?,"Yes, the statement does provide indirect support for the claim that prednisolone treats thrombocytopenia. The fact that three out of eight patients with thrombocytopenia were treated with prednisolone according to the protocol for idiopathic thrombocytopenic purpura suggests that prednisolone is being used as a treatment for thrombocytopenia in this context. However, it does not directly prove that prednisolone treats thrombocytopenia because it does not provide information on the outcomes of the treatment or whether other factors could have influenced the patients' recovery. Additionally, this is an observational study rather than a controlled clinical trial, which limits the strength of the evidence. Therefore, while there is some support for the claim, more rigorous evidence would be needed for a definitive conclusion." +7990669,Prednisolone treats non-Hodgkin lymphoma,1170,"A regimen which incorporates cyclophosphamide, doxorubicin, vincristine and prednisolone (CHOP) is the standard treatment for patients with non-Hodgkin's lymphoma (NHL), but it has not been effective in patients with aggressive NHL who are at high risk.",True,"Is the triple 'Prednisolone treats non-Hodgkin lymphoma' supported by the sentence: 'A regimen which incorporates cyclophosphamide, doxorubicin, vincristine and prednisolone (CHOP) is the standard treatment for patients with non-Hodgkin's lymphoma (NHL), but it has not been effective in patients with aggressive NHL who are at high risk.'?","Yes, indirectly it does support the statement that prednisolone treats non-Hodgkin lymphoma (NHL). The provided statement mentions that a regimen including prednisolone (CHOP) is the standard treatment for NHL patients. Although it points out that it may not be effective in high-risk patients with aggressive NHL, it does not negate prednisolone's efficacy in treating NHL generally when used in combination with other drugs in the CHOP regimen. + + +The National Comprehensive Cancer Network (NCCN) guidelines recommend CHOP as a standard first-line treatment for most NHL subtypes [1]. Prednisolone is a glucocorticoid that plays an essential role in the CHOP regimen by targeting lymphoma cells, modulating immune responses, and enhancing chemotherapy effectiveness [2]. + + +However, it is crucial to acknowledge that prednisolone alone may not be sufficient for treating NHL in many cases, as emphasized by the statement provided. Factors such as disease stage, histological subtype, patient age, performance status, and comorbidities should be" +7986379,Prednisolone treats Crohn disease,1171,"In a stepwise regression that included age, sex, disease duration and cumulative prednisolone dose as independent variables, the femur T score was significantly inversely related to disease duration (r2 = 0.125, F = 6.06) in CD patients.",False,"Is the triple 'Prednisolone treats Crohn disease' supported by the sentence: 'In a stepwise regression that included age, sex, disease duration and cumulative prednisolone dose as independent variables, the femur T score was significantly inversely related to disease duration (r2 = 0.125, F = 6.06) in CD patients.'?","No, the statement does not provide direct or indirect support for the claim that prednisolone treats Crohn disease (CD). The study mentioned in the statement is investigating the relationship between various factors including age, sex, disease duration, and cumulative prednisolone dose on bone mineral density (femur T score) in CD patients. Although it suggests an inverse relationship between disease duration and bone mineral density in CD patients who have been prescribed prednisolone, it does not provide evidence that prednisolone is an effective treatment for Crohn disease itself. The purpose of prednisolone in CD treatment is typically as an anti-inflammatory agent; hence, any impact on bone mineral density is likely an unintended side effect rather than evidence for its therapeutic efficacy in treating CD." +7985554,Prednisolone treats acute lymphoblastic leukemia,1172,"A regime of treatment of acute non-lymphoblastic leukemia in adult, employing DMCP protocol, especially two step method consisting of daunorubicin, cytosine arabinoside, 6-mercaptopurine and prednisolone is described.",False,"Is the triple 'Prednisolone treats acute lymphoblastic leukemia' supported by the sentence: 'A regime of treatment of acute non-lymphoblastic leukemia in adult, employing DMCP protocol, especially two step method consisting of daunorubicin, cytosine arabinoside, 6-mercaptopurine and prednisolone is described.'?","No, the statement does not provide direct or indirect support for the phrase ""Prednisolone treats acute lymphoblastic leukemia."" The statement discusses a treatment regimen for acute non-lymphoblastic leukemia in adults using the DMCP protocol, which includes prednisolone as part of its two-step method. However, it specifically mentions acute non-lymphoblastic leukemia, not acute lymphoblastic leukemia. These two types of leukemia are distinct diseases that may require different treatment approaches. Therefore, it is not accurate to infer that prednisolone is effective in treating acute lymphoblastic leukemia based solely on this statement." +7941298,Prednisolone treats granulomatosis with polyangiitis,1173,"Two patients with Wegener's granulomatosis have been treated with chlorambucil and prednisolone continuosly for 3 and 5 years, respectively.",True,"Is the triple 'Prednisolone treats granulomatosis with polyangiitis' supported by the sentence: 'Two patients with Wegener's granulomatosis have been treated with chlorambucil and prednisolone continuosly for 3 and 5 years, respectively.'?","Yes, the statement does provide indirect support for the claim that prednisolone treats granulomatosis with polyangiitis (GPA), which is also known as Wegener's granulomatosis. The statement indicates that two patients diagnosed with Wegener's granulomatosis were treated using chlorambucil and prednisolone continuously for 3 and 5 years, respectively. + + The use of prednisolone in these treatment courses suggests that prednisolone is an appropriate medication for managing GPA. Prednisolone is often used in combination therapy for GPA due to its potent immunosuppressive effects that can help control inflammation in vasculitis syndromes like GPA (1). + + However, it is essential to acknowledge that correlation does not imply causation, which means that although prednisolone was used in treating these patients, it does not definitively prove that prednisolone alone is responsible for their symptom improvement. The combination therapy involving chlorambucil may have also played an important role in managing their condition. + + It is worth noting that both chlorambucil and prednisolone" +7927983,Prednisolone treats nephrotic syndrome,1174,"The second patient, a 73-year-old man receiving prednisolone therapy for nephrotic syndrome, developed right leg cellulitis that evolved to NF.",False,"Is the triple 'Prednisolone treats nephrotic syndrome' supported by the sentence: 'The second patient, a 73-year-old man receiving prednisolone therapy for nephrotic syndrome, developed right leg cellulitis that evolved to NF.'?","No, the statement does not provide direct or indirect support for the claim that ""Prednisolone treats nephrotic syndrome."" In fact, it seems to suggest the opposite: The patient was already on prednisolone therapy for nephrotic syndrome when they developed cellulitis in their right leg that progressed to necrotizing fasciitis (NF). This implies that prednisolone may not be effectively treating the nephrotic syndrome in this particular case. + + However, it is important to note that a single case study does not constitute definitive evidence regarding treatment efficacy. To properly evaluate whether prednisolone treats nephrotic syndrome, one would need to analyze results from multiple clinical trials that compare prednisolone treatment outcomes in large groups of nephrotic syndrome patients against appropriate control groups." +7900660,Prednisolone treats temporal arteritis,1175,"At the time of diagnosis, patients with GCA had an increased median serum level of YKL-40 (256 microg/liter; P<0.01) compared with healthy age-matched controls (median 118 microg/liter), and the serum level of YKL-40 decreased to normal levels during prednisolone treatment (-38% after 1 month; P<0.001).",True,"Is the triple 'Prednisolone treats temporal arteritis' supported by the sentence: 'At the time of diagnosis, patients with GCA had an increased median serum level of YKL-40 (256 microg/liter; P<0.01) compared with healthy age-matched controls (median 118 microg/liter), and the serum level of YKL-40 decreased to normal levels during prednisolone treatment (-38% after 1 month; P<0.001).'?","Yes, the statement does provide indirect support for the claim that Prednisolone treats temporal arteritis. The study indicates that at the time of diagnosis, patients with Giant Cell Arteritis (GCA) have elevated levels of YKL-40 (a marker for inflammation). Following treatment with Prednisolone for one month, these levels significantly decrease (by 38%) and reach normal levels (P<0.001). This suggests that Prednisolone may have an effect on treating temporal arteritis since it reduces inflammation as indicated by YKL-40 levels. However, it is important to note that correlation does not imply causation, so further studies would need to be conducted to confirm these results and establish Prednisolone as an effective treatment for temporal arteritis." +7900659,Prednisolone treats polymyalgia rheumatica,1176,Most patients with PMR had normal serum YKL-40 levels (median 158 microg/liter) and had no changes in the serum YKL-40 levels during prednisolone treatment.,False,Is the triple 'Prednisolone treats polymyalgia rheumatica' supported by the sentence: 'Most patients with PMR had normal serum YKL-40 levels (median 158 microg/liter) and had no changes in the serum YKL-40 levels during prednisolone treatment.'?,"No, the statement does not provide indirect support for the phrase ""Prednisolone treats polymyalgia rheumatica (PMR)"". In fact, it seems to suggest that serum YKL-40 levels may not be useful as a marker for disease activity in PMR patients undergoing prednisolone treatment because there is no significant change in these levels during treatment. However, it does not refute that prednisolone can be an effective treatment for PMR. + + The statement only provides information regarding serum YKL-40 levels in PMR patients undergoing prednisolone treatment, which is not directly related to prednisolone's effectiveness in treating PMR. Further studies would be required to establish whether there is any correlation between YKL-40 levels and treatment response in PMR patients receiving prednisolone therapy. + + In conclusion, while prednisolone is commonly used as a treatment for PMR, the statement does not provide any evidence or indirect support for its efficacy in treating PMR based on YKL-40 levels." +7866839,Prednisolone treats acute myeloid leukemia,1177,"Treatment of acute myeloid leukemia of childhood with cytosine arabinoside, daunorubicin, prednisolone, and mercaptopurine or thioguanine.",True,"Is the triple 'Prednisolone treats acute myeloid leukemia' supported by the sentence: 'Treatment of acute myeloid leukemia of childhood with cytosine arabinoside, daunorubicin, prednisolone, and mercaptopurine or thioguanine.'?","Yes, the statement does provide indirect support for the claim that prednisolone treats acute myeloid leukemia. The provided statement mentions prednisolone as part of a treatment regimen for acute myeloid leukemia in children, which suggests that prednisolone is used in treating this type of leukemia. However, it is important to note that prednisolone is likely not used alone in treating acute myeloid leukemia but as part of a combination therapy regimen including other drugs such as cytosine arabinoside, daunorubicin, mercaptopurine or thioguanine. + + In conclusion, while the statement does not explicitly confirm that prednisolone treats acute myeloid leukemia on its own, it does provide evidence that prednisolone is used in treating acute myeloid leukemia as part of a combination therapy regimen." +7819165,Prednisolone treats systemic lupus erythematosus,1178,Subacute severe steatohepatitis during prednisolone therapy for systemic lupus erythematosis.,True,Is the triple 'Prednisolone treats systemic lupus erythematosus' supported by the sentence: 'Subacute severe steatohepatitis during prednisolone therapy for systemic lupus erythematosis.'?,"Yes, indirectly it does support that statement. The given statement mentions ""prednisolone therapy for systemic lupus erythematosis"" which implies that prednisolone is used in treating systemic lupus erythematosus (SLE). The original phrase ""Prednisolone treats systemic lupus erythematosus"" is also generally true as prednisolone is indeed a common corticosteroid used in treating SLE due to its anti-inflammatory effects. + + However, the provided statement does not explicitly confirm that prednisolone treats SLE; it only shows that prednisolone was used during therapy for SLE and that subacute severe steatohepatitis occurred during that time. This does not necessarily mean that prednisolone caused steatohepatitis; it could be a side effect or it could be coincidental timing. Therefore, while there is some indirect support for prednisolone treating SLE from this statement, it is not definitive proof on its own." +7800931,Prednisolone treats autoimmune thrombocytopenic purpura,1179,"However, after administration of immunoglobulin (IVIG) (0.4 g/kg/day x 5 days), low-dose PSL (20 mg/day) alleviated the LEMS and ITP, and the diseases have remained in remission for 8 months without additional IVIG.",True,"Is the triple 'Prednisolone treats autoimmune thrombocytopenic purpura' supported by the sentence: 'However, after administration of immunoglobulin (IVIG) (0.4 g/kg/day x 5 days), low-dose PSL (20 mg/day) alleviated the LEMS and ITP, and the diseases have remained in remission for 8 months without additional IVIG.'?","Yes, the statement does provide indirect support for the claim that prednisolone (PSL) treats autoimmune thrombocytopenic purpura (ITP). The statement indicates that low-dose PSL (20 mg/day) was administered in conjunction with immunoglobulin (IVIG) therapy for ITP treatment, leading to remission for 8 months without additional IVIG treatment. This implies that PSL may have contributed to the alleviation of ITP symptoms in this case. However, it is important to note that PSL was used in combination with IVIG therapy, so it cannot be definitively concluded that PSL is solely responsible for treating ITP in this instance. Additionally, further studies would be needed to confirm that prednisolone is an effective treatment for ITP in general." +7704078,Prednisolone treats colitis,1180,"On the other hand, prednisolone and short chain fatty acids seemed to improve only the physiologic changes of colitis.",True,"Is the triple 'Prednisolone treats colitis' supported by the sentence: 'On the other hand, prednisolone and short chain fatty acids seemed to improve only the physiologic changes of colitis.'?","Yes, the statement ""Prednisolone and short chain fatty acids seemed to improve only the physiologic changes of colitis"" does lend indirect support to the claim that ""Prednisolone treats colitis."" The key term here is ""physiologic changes,"" which can be interpreted as improvements in the physical condition or manifestations of colitis. + + However, it is important to note that ""treats"" is a strong term that implies resolution or management of the disease as a whole, rather than just its physiologic changes. Therefore, while there is some level of support for prednisolone having a positive impact on colitis based on this statement alone, it would be more accurate to say that prednisolone ameliorates certain aspects of colitis rather than it ""treats"" colitis outright. + + Furthermore, it is also crucial to consider other factors such as side effects, long-term efficacy, dosage, and patient response variability when making judgments about medical treatments based on single statements from research studies. Comprehensive evaluation should be performed using multiple sources of information in order to fully understand any given therapeutic intervention in healthcare" +7676165,Prednisolone treats hypercalcemia disease,1181,"Treatment with extracorporeal shock wave lithotripsy, transurethral lithotomy, saline infusion, and prednisolone (30 mg/day) alleviated the urolithiasis, renal insufficiency, and hypercalcemia.",True,"Is the triple 'Prednisolone treats hypercalcemia disease' supported by the sentence: 'Treatment with extracorporeal shock wave lithotripsy, transurethral lithotomy, saline infusion, and prednisolone (30 mg/day) alleviated the urolithiasis, renal insufficiency, and hypercalcemia.'?","Yes, the statement does provide indirect support for the phrase ""Prednisolone treats hypercalcemia disease"". The reason is that in the provided context, prednisolone is used as part of a treatment regimen for a patient suffering from urolithiasis, renal insufficiency, and hypercalcemia. The fact that these conditions were alleviated suggests that prednisolone might have contributed to improving hypercalcemia specifically, given that it is one of the mentioned treatments and hypercalcemia is explicitly listed among the conditions treated in this case. However, it is important to note that such an interpretation is based on an indirect inference since multiple treatments were administered concurrently, making it impossible to attribute the improvement solely to prednisolone without further investigation." +7603475,Prednisolone treats Duchenne muscular dystrophy,1182,A special program for long-term application of low-dose prednisolone treatment in Duchenne-Becker muscular dystrophy with complex control of the patients' state was developed.,True,Is the triple 'Prednisolone treats Duchenne muscular dystrophy' supported by the sentence: 'A special program for long-term application of low-dose prednisolone treatment in Duchenne-Becker muscular dystrophy with complex control of the patients' state was developed.'?,"Yes, indirectly it does lend some support. The statement mentions that a program for long-term application of low-dose prednisolone treatment was developed specifically for Duchenne-Becker muscular dystrophy. This suggests that prednisolone may have some therapeutic effect on Duchenne muscular dystrophy, given that it is being used as part of a treatment program for this condition. However, it's important to note that this doesn't necessarily mean that prednisolone alone treats Duchenne muscular dystrophy. The statement suggests that prednisolone is used as part of a complex treatment regimen, which implies that it may be one component of a larger treatment strategy rather than being an independent treatment for Duchenne muscular dystrophy." +7600829,Prednisolone treats multiple sclerosis,1183,"Long-term open-trial of mizoribine with prednisolone in 24 patients with multiple sclerosis: safety, clinical and magnetic resonance imaging outcome.",False,"Is the triple 'Prednisolone treats multiple sclerosis' supported by the sentence: 'Long-term open-trial of mizoribine with prednisolone in 24 patients with multiple sclerosis: safety, clinical and magnetic resonance imaging outcome.'?","No, the statement does not provide direct support for the claim that prednisolone treats multiple sclerosis. The study mentioned is an open-trial involving mizoribine and prednisolone in patients with multiple sclerosis, focusing on safety, clinical outcomes, and magnetic resonance imaging results. While prednisolone is part of the treatment regimen in this study, it does not necessarily imply that prednisolone alone is responsible for treating multiple sclerosis since it is used in combination with mizoribine in these patients. Additional studies focusing specifically on prednisolone as a treatment for multiple sclerosis would be required for more direct support for that claim." +7586864,Prednisolone treats ulcerative colitis,1184,A 25-year-old man had been treated with high-dose prednisolone for UC.,True,Is the triple 'Prednisolone treats ulcerative colitis' supported by the sentence: 'A 25-year-old man had been treated with high-dose prednisolone for UC.'?,"Yes, indirectly it does lend support to the claim that prednisolone treats ulcerative colitis (UC). The statement ""A 25-year-old man had been treated with high-dose prednisolone for UC"" implies that prednisolone was used as a treatment for UC in this particular case. However, it is important to note that while anecdotal evidence can suggest a trend, it does not definitively prove that prednisolone is an effective treatment for UC in all cases due to factors such as individual patient responses, dosage levels, duration of treatment, and potential side effects. Therefore, further clinical studies would be necessary for more robust support for this claim." +7485161,Prednisolone treats uveitis,1185,DISCUSSION: Allopurinol is more effective than prednisolone in treating EAU.,False,Is the triple 'Prednisolone treats uveitis' supported by the sentence: 'DISCUSSION: Allopurinol is more effective than prednisolone in treating EAU.'?,"No, the statement ""Allopurinol is more effective than prednisolone in treating EAU"" does not provide indirect support for the claim that ""Prednisolone treats uveitis."" In fact, it could be interpreted as suggesting that prednisolone might not be as effective in treating uveitis as another drug (in this case, allopurinol). However, it does not necessarily mean that prednisolone has no therapeutic effect on uveitis. It is important to note that uveitis is a complex condition with various forms and causes, so further investigation would be required to determine prednisolone's specific efficacy in treating uveitis." +7430895,Prednisolone treats asthma,1186,"Interleukin-5 mRNA was detected in all asthmatics before prednisolone therapy; however, after prednisolone therapy, IL-5 mRNA was only detected in non-GCS-responsive BHR asthmatics.",False,"Is the triple 'Prednisolone treats asthma' supported by the sentence: 'Interleukin-5 mRNA was detected in all asthmatics before prednisolone therapy; however, after prednisolone therapy, IL-5 mRNA was only detected in non-GCS-responsive BHR asthmatics.'?","No, the statement does not provide direct or indirect support for the phrase ""Prednisolone treats asthma."" The given statement discusses the presence of Interleukin-5 (IL-5) mRNA in asthmatics before and after prednisolone therapy, but it does not provide information about prednisolone's therapeutic effect on asthma symptoms or severity, which is essential for supporting the claim that prednisolone treats asthma." +7417999,Prednisolone treats IgA glomerulonephritis,1187,"Combined therapy with prednisolone, azathioprine, heparin-warfarin, and dipyridamole for paediatric patients with severe IgA nephropathy--is it relevant for adult patients?",False,"Is the triple 'Prednisolone treats IgA glomerulonephritis' supported by the sentence: 'Combined therapy with prednisolone, azathioprine, heparin-warfarin, and dipyridamole for paediatric patients with severe IgA nephropathy--is it relevant for adult patients?'?","No, the statement does not provide indirect support for the phrase ""Prednisolone treats IgA glomerulonephritis."" The original statement discusses combined therapy for paediatric patients with severe IgA nephropathy (a type of glomerulonephritis), which includes prednisolone as one component among others like azathioprine, heparin-warfarin, and dipyridamole. The focus is on treatment for severe IgA nephropathy in paediatric patients rather than specifically addressing IgA glomerulonephritis or adult patients. + + To provide indirect support for ""Prednisolone treats IgA glomerulonephritis,"" there would need to be some connection drawn between prednisolone as an effective treatment for IgA glomerulonephritis in particular. The current statement does not establish such a connection explicitly or implicitly." +7158230,Prednisolone treats rheumatoid arthritis,1188,Remission of the nephrotic syndrome in a patient with renal amyloidosis due to rheumatoid arthritis treated with prednisolone and methotrexate.,True,Is the triple 'Prednisolone treats rheumatoid arthritis' supported by the sentence: 'Remission of the nephrotic syndrome in a patient with renal amyloidosis due to rheumatoid arthritis treated with prednisolone and methotrexate.'?,"Yes, there is indirect support for the claim that prednisolone treats rheumatoid arthritis in the statement provided. The nephrotic syndrome is a known complication of rheumatoid arthritis (RA), and its remission indicates an improvement in RA symptoms. The patient was treated with both prednisolone and methotrexate; therefore, we cannot attribute the remission solely to prednisolone. However, prednisolone is a glucocorticoid commonly used in RA treatment regimens due to its anti-inflammatory properties that help manage RA symptoms. Thus, it suggests that prednisolone has some therapeutic effect on RA in this specific case even though it was used in combination therapy." +23769275,Hydrocortisone treats leukemia,1189,"Study protocol: DexaDays-2, hydrocortisone for treatment of dexamethasone-induced neurobehavioral side effects in pediatric leukemia patients: a double-blind placebo controlled randomized intervention study with cross-over design.",False,"Is the triple 'Hydrocortisone treats leukemia' supported by the sentence: 'Study protocol: DexaDays-2, hydrocortisone for treatment of dexamethasone-induced neurobehavioral side effects in pediatric leukemia patients: a double-blind placebo controlled randomized intervention study with cross-over design.'?","No, the statement does not provide direct or indirect support for the claim that hydrocortisone treats leukemia. The study protocol focuses on using hydrocortisone as an intervention for dexamethasone-induced neurobehavioral side effects in pediatric leukemia patients. The primary objective here is managing side effects caused by dexamethasone treatment rather than treating leukemia itself using hydrocortisone. + + To establish whether hydrocortisone can treat leukemia indirectly based on this study protocol, we would need evidence suggesting that addressing these neurobehavioral side effects can lead to better leukemia treatment outcomes in pediatric patients. However, since there is no mention of such evidence in the study protocol provided, we cannot infer that hydrocortisone has any indirect effect on leukemia treatment. + + In summary, while hydrocortisone might have some impact on pediatric leukemia patients due to its potential influence on neurobehavioral side effects during dexamethasone treatment, there is no solid basis in the given study protocol for claiming that hydrocortisone treats leuk" +22345112,Hydrocortisone treats oral submucous fibrosis,1190,"Aims and Objective: To evaluate the efficacy of injection placentrex and injection hydrocortisone in oral submucous fibrosis patients in increasing mouth opening, burning sensation, and improve the mucosal lining.",True,"Is the triple 'Hydrocortisone treats oral submucous fibrosis' supported by the sentence: 'Aims and Objective: To evaluate the efficacy of injection placentrex and injection hydrocortisone in oral submucous fibrosis patients in increasing mouth opening, burning sensation, and improve the mucosal lining.'?","Yes, indirectly it does support the claim that hydrocortisone treats oral submucous fibrosis (OSF). The statement mentions an ""evaluation of the efficacy"" for injection hydrocortisone in OSF patients concerning increasing mouth opening, burning sensation alleviation, and mucosal lining improvement. By assessing its efficacy in treating these symptoms associated with OSF, one can infer that hydrocortisone has potential therapeutic benefits for OSF patients. However, it is essential to consider that indirect support does not equate to definitive proof, as further investigation would be required for stronger evidence-based conclusions regarding hydrocortisone's effectiveness in treating OSF." +22282269,Hydrocortisone treats Infection,1191,"The results presented herein imply that the three families of cyanine dyes, in particular compounds 5a-f, show high potential as selective scaffolds to treat C. albicans infections.",False,"Is the triple 'Hydrocortisone treats Infection' supported by the sentence: 'The results presented herein imply that the three families of cyanine dyes, in particular compounds 5a-f, show high potential as selective scaffolds to treat C. albicans infections.'?","No, the phrase ""Hydrocortisone treats Infection"" does not receive at least indirect support from the statement: ""The results presented herein imply that the three families of cyanine dyes, in particular compounds 5a-f, show high potential as selective scaffolds to treat C. albicans infections."" + + The statement specifically refers to cyanine dyes, particularly compounds 5a-f, as having high potential for treating C. albicans infections. Hydrocortisone is not mentioned anywhere in the statement, nor is it implied as a treatment for any kind of infection. Therefore, there is no indirect support for the claim that hydrocortisone treats infection based on this statement." +21368080,Hydrocortisone treats lymphoma,1192,The serum cortisol concentration in the LYMPH patients was 285 +/- 74 nmol/l.,False,Is the triple 'Hydrocortisone treats lymphoma' supported by the sentence: 'The serum cortisol concentration in the LYMPH patients was 285 +/- 74 nmol/l.'?,"No, the statement ""The serum cortisol concentration in the LYMPH patients was 285 +/- 74 nmol/l"" does not provide indirect support for the claim that ""Hydrocortisone treats lymphoma."" This is because measuring serum cortisol levels in lymphoma patients does not inherently demonstrate that administering hydrocortisone (a synthetic form of cortisol) will result in therapeutic benefits for these patients. To establish indirect support for such a claim, there would need to be additional evidence showing that hydrocortisone has an impact on lymphoma progression, patient survival, or related outcomes in clinical settings. The provided statement only offers information about cortisol levels in lymphoma patients but does not explicitly link hydrocortisone treatment to any potential benefits for these patients." +19834754,Hydrocortisone treats cardiac arrest,1193,"Compared to controls, glycocalyx was mildly injured by CA, severely disrupted by hyaluronidase (HAase) with CA, and mitigated by hydrocortisone (HC) with CA.",False,"Is the triple 'Hydrocortisone treats cardiac arrest' supported by the sentence: 'Compared to controls, glycocalyx was mildly injured by CA, severely disrupted by hyaluronidase (HAase) with CA, and mitigated by hydrocortisone (HC) with CA.'?","No, the statement does not provide direct or indirect support for the claim that hydrocortisone treats cardiac arrest (CA). The provided information discusses the effects of hydrocortisone (HC) on glycocalyx in relation to hyaluronidase (HAase) and cardiac arrest; however, it does not establish a causal relationship between hydrocortisone administration and improvements in cardiac arrest outcomes. Further investigation and evidence would be required to make such a claim." +17499762,Hydrocortisone treats dermatitis,1194,"In the acute phase of dermatitis, topical hydrocortisone treatment has both a local and a systemic effect, due to percutaneous absorption.",True,"Is the triple 'Hydrocortisone treats dermatitis' supported by the sentence: 'In the acute phase of dermatitis, topical hydrocortisone treatment has both a local and a systemic effect, due to percutaneous absorption.'?","Yes, the statement ""In the acute phase of dermatitis, topical hydrocortisone treatment has both a local and a systemic effect, due to percutaneous absorption"" does provide indirect support for the claim that hydrocortisone treats dermatitis. The key phrase here is ""topical hydrocortisone treatment,"" which implies that hydrocortisone is being used as a therapeutic agent for dermatitis. The statement also mentions that hydrocortisone has both local (presumably at the site of application on the skin) and systemic effects (throughout the body), suggesting that it can indeed have an impact on dermatitis symptoms. However, it is important to note that while this statement supports the efficacy of hydrocortisone in treating dermatitis, it does not necessarily confirm that hydrocortisone is the best or only treatment option available for dermatitis." +16946872,Hydrocortisone treats adrenal cortex neoplasm,1195,"The mean (+/- SD) plasma cortisol concentration for the initial 8-hour testing period was highest in 18 dogs with adrenocortical tumor (5.3 +/- 1.6 micrograms/dl), lowest in 15 control dogs (1.3 +/- 0.5 micrograms/dl), and intermediate in 31 dogs with pituitary-dependent hyperadrenocorticism (PDH; 3.4 +/- 1.2 micrograms/dl).",False,"Is the triple 'Hydrocortisone treats adrenal cortex neoplasm' supported by the sentence: 'The mean (+/- SD) plasma cortisol concentration for the initial 8-hour testing period was highest in 18 dogs with adrenocortical tumor (5.3 +/- 1.6 micrograms/dl), lowest in 15 control dogs (1.3 +/- 0.5 micrograms/dl), and intermediate in 31 dogs with pituitary-dependent hyperadrenocorticism (PDH; 3.4 +/- 1.2 micrograms/dl).'?","No, the statement does not provide direct support for the phrase ""Hydrocortisone treats adrenal cortex neoplasm"". The statement presents data on plasma cortisol concentrations in dogs with different conditions, including adrenocortical tumor, pituitary-dependent hyperadrenocorticism (PDH), and control dogs. However, it does not mention hydrocortisone or its therapeutic effects on adrenal cortex neoplasm. + + To provide indirect support for the claim, there should be some connection between hydrocortisone and adrenal cortex neoplasm in the statement. For example, if it mentioned that hydrocortisone was used to treat dogs with adrenal cortex neoplasm and resulted in decreased cortisol levels, then it would provide indirect support for the claim. Nonetheless, without such information, it is not possible to infer any relationship between hydrocortisone and adrenal cortex neoplasm from the given statement." +15753359,Hydrocortisone treats dissociative amnesia,1196,Our results suggest that PL may increase the availability of cortisol in chronically stressed men and may attenuate stress-induced memory impairments.,False,Is the triple 'Hydrocortisone treats dissociative amnesia' supported by the sentence: 'Our results suggest that PL may increase the availability of cortisol in chronically stressed men and may attenuate stress-induced memory impairments.'?,"No, the phrase ""Hydrocortisone treats dissociative amnesia"" does not receive indirect support from the statement: ""Our results suggest that PL may increase the availability of cortisol in chronically stressed men and may attenuate stress-induced memory impairments."" + + The statement refers to a study involving PL (presumably a drug or intervention) and its effects on cortisol availability in chronically stressed men, as well as potential benefits for stress-induced memory impairments. However, hydrocortisone is not mentioned in the statement; it is a synthetic form of cortisol used primarily for replacing deficient cortisol in patients with adrenal insufficiency rather than treating dissociative amnesia specifically. + + Furthermore, dissociative amnesia is not explicitly addressed in the statement; stress-induced memory impairments do not necessarily equate to dissociative amnesia as dissociative amnesia is characterized by gaps in memory that cannot be explained by ordinary forgetfulness and is often linked to traumatic experiences. + + Therefore, without further information linking hydrocortisone, PL (if indeed PL is hydroc" +15602187,Hydrocortisone treats Hypoxemia,1197,All inhibitors prevented the rise in cortisol secretion usually observed in hypoxic dogs.,False,Is the triple 'Hydrocortisone treats Hypoxemia' supported by the sentence: 'All inhibitors prevented the rise in cortisol secretion usually observed in hypoxic dogs.'?,"No, the statement ""All inhibitors prevented the rise in cortisol secretion usually observed in hypoxic dogs"" does not provide direct or indirect support for the claim ""Hydrocortisone treats Hypoxemia."" + + The original statement discusses how ""all inhibitors"" prevent an increase in cortisol secretion in hypoxic dogs, which is not explicitly related to hydrocortisone treating hypoxemia (low oxygen levels in blood). Hydrocortisone is a steroid hormone that is often used as an anti-inflammatory agent; it is not typically considered an ""inhibitor"" in terms used in hypoxia research. + + In order for us to assess if hydrocortisone could treat hypoxemia, we would need evidence that specifically addresses hydrocortisone administration in hypoxemic conditions and its impact on oxygenation levels in animals or humans. The provided statement does not offer such evidence; thus, it does not support the claim that hydrocortisone treats hypoxemia." +15325707,Hydrocortisone treats psoriasis,1198,"The expression of StAR and MLN64 was aberrant in two skin disorders, psoriasis and atopic dermatitis, that are commonly treated with cortisol, suggesting dysregulation of epidermal steroid synthesis in these patients.",False,"Is the triple 'Hydrocortisone treats psoriasis' supported by the sentence: 'The expression of StAR and MLN64 was aberrant in two skin disorders, psoriasis and atopic dermatitis, that are commonly treated with cortisol, suggesting dysregulation of epidermal steroid synthesis in these patients.'?","No, the statement does not provide direct or indirect support for the phrase ""Hydrocortisone treats psoriasis."" The statement discusses aberrant expression of StAR and MLN64 in psoriasis and atopic dermatitis, which implies dysregulation of epidermal steroid synthesis in these patients. However, it does not mention hydrocortisone specifically nor does it provide evidence that hydrocortisone is an effective treatment for psoriasis. Hydrocortisone is a type of corticosteroid, but different corticosteroids have different properties and may not all be equally effective for treating psoriasis. Therefore, while it is possible that hydrocortisone could be used to treat psoriasis, this statement does not provide evidence for that claim." +15213238,Hydrocortisone treats herpes labialis,1199,"ME-609 (Xerese, Xerclear) is a combination of 5% acyclovir and 1% hydrocortisone developed for the topical treatment of HSL.",False,"Is the triple 'Hydrocortisone treats herpes labialis' supported by the sentence: 'ME-609 (Xerese, Xerclear) is a combination of 5% acyclovir and 1% hydrocortisone developed for the topical treatment of HSL.'?","No, the statement does not provide direct or indirect support for the claim that ""Hydrocortisone treats herpes labialis."" While it is true that ME-609 is a topical treatment for Herpes Labialis Simplex (HSL) containing 1% hydrocortisone, it does not imply that hydrocortisone alone is responsible for treating HSL. Furthermore, even if hydrocortisone had an effect on HSL, it would not necessarily mean that it treats herpes labialis as treating an infection implies causality and complete resolution which cannot be inferred from this statement alone." +14532907,Hydrocortisone treats cirrhosis of liver,1200,The urinary ratio of 6 beta-hydroxycortisol/cortisol (6 beta-OHC/C) as a biomarker of CYP3A4 metabolizing activity has been studied in Egyptian patients with chronic liver cirrhosis associated with previous hepatic Schistosomiasis infection to determine any possible alteration in enzyme activity.,False,Is the triple 'Hydrocortisone treats cirrhosis of liver' supported by the sentence: 'The urinary ratio of 6 beta-hydroxycortisol/cortisol (6 beta-OHC/C) as a biomarker of CYP3A4 metabolizing activity has been studied in Egyptian patients with chronic liver cirrhosis associated with previous hepatic Schistosomiasis infection to determine any possible alteration in enzyme activity.'?,"No, the statement does not provide indirect support for the claim that hydrocortisone treats cirrhosis of the liver. The statement discusses a study on Egyptian patients with chronic liver cirrhosis associated with previous hepatic Schistosomiasis infection, focusing on the urinary ratio of 6 beta-hydroxycortisol/cortisol (6 beta-OHC/C) as a biomarker for CYP3A4 metabolizing activity. While it is true that hydrocortisone is metabolized by CYP3A4 enzymes in the liver, there is no mention of hydrocortisone being used as a treatment for cirrhosis in this study or statement. Therefore, it does not provide any evidence or support for that specific claim." +14075841,Hydrocortisone treats acute lymphoblastic leukemia,1201,"Here, we report a case of fatal ATLS complicating intrathecal injections of methotrexate, cytarabine and hydrocortisone for acute lymphoblastic leukemia which relapsed with meningeal involvement after allogeneic stem cell transplantation.",False,"Is the triple 'Hydrocortisone treats acute lymphoblastic leukemia' supported by the sentence: 'Here, we report a case of fatal ATLS complicating intrathecal injections of methotrexate, cytarabine and hydrocortisone for acute lymphoblastic leukemia which relapsed with meningeal involvement after allogeneic stem cell transplantation.'?","No, the statement does not provide indirect support for the claim that ""Hydrocortisone treats acute lymphoblastic leukemia."" The statement reports a case where hydrocortisone was used in combination with other drugs for treating acute lymphoblastic leukemia (ALL) that had relapsed with meningeal involvement after allogeneic stem cell transplantation. The use of hydrocortisone in this context is for managing complications associated with ALL rather than treating ALL itself. The misconception arises due to conflating treating complications associated with ALL and treating ALL itself." +13951019,Hydrocortisone treats HIV infectious disease,1202,"Except in one patient with HIV infection, all the signs and symptoms improved after antituberculous and hydrocortisone treatment.",False,"Is the triple 'Hydrocortisone treats HIV infectious disease' supported by the sentence: 'Except in one patient with HIV infection, all the signs and symptoms improved after antituberculous and hydrocortisone treatment.'?","No, the phrase ""Hydrocortisone treats HIV infectious disease"" does not receive direct or indirect support from the statement: ""Except in one patient with HIV infection, all the signs and symptoms improved after antituberculous and hydrocortisone treatment."" + + The statement indicates that hydrocortisone treatment was associated with improvement in signs and symptoms in patients receiving antituberculous therapy, except for one patient who had HIV infection. This suggests that hydrocortisone may have had an effect on tuberculosis symptoms in most patients; however, it does not provide evidence that hydrocortisone is responsible for treating HIV infectious disease itself. + + Therefore, it is inappropriate to infer that hydrocortisone has any therapeutic effect on HIV infection based on the given statement alone. Further investigation is required through controlled clinical trials specifically designed to test hydrocortisone as an intervention for HIV infection before such conclusions can be drawn." +13724762,Hydrocortisone treats severe acute respiratory syndrome,1203,"Cortisol levels are elevated in patients with RSV and Ebola, and cortisol was higher in SARS patients with lymphopenia before any steroid therapy.",False,"Is the triple 'Hydrocortisone treats severe acute respiratory syndrome' supported by the sentence: 'Cortisol levels are elevated in patients with RSV and Ebola, and cortisol was higher in SARS patients with lymphopenia before any steroid therapy.'?","No, the statement does not provide indirect support for the claim that hydrocortisone treats severe acute respiratory syndrome (SARS). The statement highlights that cortisol levels are elevated in patients suffering from respiratory syncytial virus (RSV), Ebola, and SARS (with lymphopenia). However, it does not provide any information on whether administering hydrocortisone (a synthetic form of cortisol) would have any therapeutic effects on SARS patients. + + To provide indirect support for the original claim, there would need to be some connection between cortisol/hydrocortisone administration and an improvement in SARS symptoms, which is not mentioned in the given statement. Therefore, more evidence is required before accepting that hydrocortisone could be an effective treatment for SARS based on cortisol level observations alone." +13691671,Hydrocortisone treats Insulin resistance,1204,OBJECTIVE: To investigate possible effects of insulin-sensitizing treatment on cortisol metabolism in insulin-resistant patients with polycystic ovary syndrome (PCOS).,False,Is the triple 'Hydrocortisone treats Insulin resistance' supported by the sentence: 'OBJECTIVE: To investigate possible effects of insulin-sensitizing treatment on cortisol metabolism in insulin-resistant patients with polycystic ovary syndrome (PCOS).'?,"No, the statement does not provide direct support for the phrase ""Hydrocortisone treats Insulin resistance."" The objective in the statement is focused on investigating possible effects of insulin-sensitizing treatment on cortisol metabolism in insulin-resistant patients with polycystic ovary syndrome (PCOS). Hydrocortisone is a glucocorticoid hormone and not an insulin-sensitizing agent. Even though it may have some indirect relationship through its impact on cortisol metabolism, it does not directly treat insulin resistance based on the information provided in the statement alone." +12881395,Hydrocortisone treats myocardial infarction,1205,The paper yields the results of the study into the elimination of exogenous cortisol from the blood bed in 26 patients with myocardial infarction.,False,Is the triple 'Hydrocortisone treats myocardial infarction' supported by the sentence: 'The paper yields the results of the study into the elimination of exogenous cortisol from the blood bed in 26 patients with myocardial infarction.'?,"No, the statement does not provide indirect support for the claim that hydrocortisone treats myocardial infarction. The study mentioned in the statement investigates the elimination of exogenous cortisol from the blood bed in patients with myocardial infarction, but it does not mention hydrocortisone specifically. Cortisol is a naturally occurring hormone in the human body, while hydrocortisone is a synthetic form of cortisol used in medications for various conditions. Therefore, we cannot infer that hydrocortisone is being used in this study based solely on the provided information. + + However, it is important to note that hydrocortisone has been studied in relation to myocardial infarction in other contexts as an anti-inflammatory agent for treating cardiac complications. Nonetheless, without additional information linking hydrocortisone to the study mentioned in the statement, we cannot infer that it is being used as a treatment for myocardial infarction in this case." +12524121,Hydrocortisone treats neoplasm,1206,"Retinoic acid treatment controls ACTH and cortisol hyperactivity and tumor size in dogs with ACTH-secreting tumors, leading to resolution of the clinical phenotype.",False,"Is the triple 'Hydrocortisone treats neoplasm' supported by the sentence: 'Retinoic acid treatment controls ACTH and cortisol hyperactivity and tumor size in dogs with ACTH-secreting tumors, leading to resolution of the clinical phenotype.'?","No, the statement does not provide direct or indirect support for the claim that ""Hydrocortisone treats neoplasm."" The study referenced in the statement investigates the effects of retinoic acid treatment on dogs suffering from ACTH-secreting tumors (a type of neoplasm), focusing on ACTH and cortisol hyperactivity as well as tumor size reduction leading to resolution of clinical symptoms. However, hydrocortisone is not mentioned in this study as a treatment option for neoplasm; therefore, it does not lend support for that specific claim. + + While both hydrocortisone and retinoic acid can have effects on cortisol levels in the body due to their glucocorticoid properties, they should not be assumed interchangeable in treating neoplasms based on this one study alone. Further investigation is required before making any definitive conclusions about hydrocortisone's efficacy in treating neoplasms based on retinoic acid studies." +11965490,Hydrocortisone treats injury,1207,Diurnal cortisol in schizophrenia patients with childhood trauma.,False,Is the triple 'Hydrocortisone treats injury' supported by the sentence: 'Diurnal cortisol in schizophrenia patients with childhood trauma.'?,"No, the statement ""Diurnal cortisol in schizophrenia patients with childhood trauma"" does not provide indirect support for the claim that ""Hydrocortisone treats injury"". + + The statement discusses diurnal cortisol levels in schizophrenia patients who have experienced childhood trauma. Cortisol is a stress hormone that follows a diurnal rhythm, meaning it has regular fluctuations throughout the day. The study might be investigating how childhood trauma affects cortisol levels in schizophrenia patients. However, it does not mention hydrocortisone or its therapeutic effects in treating injuries. Hydrocortisone is a synthetic glucocorticoid hormone often used in medicine for its anti-inflammatory properties in treating various conditions such as allergies, skin disorders, and autoimmune diseases; it is not typically used for treating injuries in general. + + In conclusion, while both statements discuss cortisol-related topics, they do not provide any indirect support for each other as they cover different areas within cortisol research." +11029944,Hydrocortisone treats eye disorder,1208,Topical compound F in the treatment of anterior segment eye disease; a preliminary report.,False,Is the triple 'Hydrocortisone treats eye disorder' supported by the sentence: 'Topical compound F in the treatment of anterior segment eye disease; a preliminary report.'?,"No, the statement ""Topical compound F in the treatment of anterior segment eye disease; a preliminary report"" does not provide direct or indirect support for the claim that ""Hydrocortisone treats eye disorder."" The statement refers specifically to topical compound F, not hydrocortisone, as a potential treatment for anterior segment eye disease. Additionally, it is only a preliminary report, indicating that further investigation is needed before any definitive conclusions can be drawn about its efficacy as a treatment option." +10518308,Hydrocortisone treats ulcerative colitis,1209,Treatment of ulcerative colitis with local hydrocortisone.,True,Is the triple 'Hydrocortisone treats ulcerative colitis' supported by the sentence: 'Treatment of ulcerative colitis with local hydrocortisone.'?,"Yes, the statement ""Treatment of ulcerative colitis with local hydrocortisone"" does provide indirect support for the claim that ""Hydrocortisone treats ulcerative colitis."" This is because it suggests that hydrocortisone has been used successfully in treating ulcerative colitis in some capacity. However, it is important to note that direct support would require more explicit evidence linking hydrocortisone as an effective treatment for ulcerative colitis in general, not only in local applications. Also, it should be considered that ulcerative colitis is a complex disease that may require personalized treatment plans due to its various manifestations in patients. Therefore, while hydrocortisone might be helpful in treating certain cases or symptoms, it might not be equally effective for all patients suffering from ulcerative colitis." +10516843,Hydrocortisone treats diffuse alopecia areata,1210,"Alopecia areata, partialis, and totalis; treatment with cortisone, hydrocortisone and their analogs, prednisone and prednisolone.",True,"Is the triple 'Hydrocortisone treats diffuse alopecia areata' supported by the sentence: 'Alopecia areata, partialis, and totalis; treatment with cortisone, hydrocortisone and their analogs, prednisone and prednisolone.'?","Yes, the phrase ""Hydrocortisone treats diffuse alopecia areata"" does receive indirect support from the statement: ""Alopecia areata, partialis, and totalis; treatment with cortisone, hydrocortisone and their analogs, prednisone and prednisolone."" + + The statement provides indirect evidence that hydrocortisone can be used in treating alopecia areata because it is listed as one of the treatment options alongside other corticosteroids such as cortisone, prednisone, and prednisolone for alopecia conditions (areata, partialis, and totalis). Alopecia areata is a form of hair loss that can be diffuse (spread out evenly over the scalp) or patchy (in specific areas). Therefore, if hydrocortisone is effective in treating alopecia areata in general, it can also be applied to diffuse alopecia areata. However, it is essential to note that further investigation would be necessary for more direct support since the original statement does not explicitly mention diffuse alopecia areata in conjunction with hydroc" +10492262,Hydrocortisone treats osteoarthritis,1211,Phenylbutazone and compound F for osteoarthritis of the hip; a survey and clinical report.,False,Is the triple 'Hydrocortisone treats osteoarthritis' supported by the sentence: 'Phenylbutazone and compound F for osteoarthritis of the hip; a survey and clinical report.'?,"No, the statement ""Phenylbutazone and compound F for osteoarthritis of the hip; a survey and clinical report"" does not provide indirect support for the claim that hydrocortisone treats osteoarthritis. The statement only mentions phenylbutazone and compound F as potential treatments for osteoarthritis, but it does not mention hydrocortisone at all. Therefore, there is no basis for inferring that hydrocortisone is an effective treatment for osteoarthritis from this statement alone. + + + + However, it is worth noting that hydrocortisone is indeed used as an injectable treatment for osteoarthritis in some cases due to its anti-inflammatory properties. This use is supported by other studies that have specifically investigated hydrocortisone as a treatment for osteoarthritis. Nonetheless, based solely on the statement provided, there is no evidence to support the claim that hydrocortisone is an effective treatment for osteoarthritis." +10480635,Hydrocortisone treats atopic conjunctivitis,1212,"Hydrocortisone in treatment of allergic conjunctivitis, allergic rhinitis, and bronchial asthma.",True,"Is the triple 'Hydrocortisone treats atopic conjunctivitis' supported by the sentence: 'Hydrocortisone in treatment of allergic conjunctivitis, allergic rhinitis, and bronchial asthma.'?","Yes, the statement ""Hydrocortisone in treatment of allergic conjunctivitis, allergic rhinitis, and bronchial asthma"" does lend indirect support to the claim that hydrocortisone treats atopic conjunctivitis. This is because atopic conjunctivitis falls under the broader category of allergic conjunctivitis, which is explicitly mentioned in the provided statement as being treated by hydrocortisone. + + + + However, it is important to note that while the statement provides some level of support for the claim, it does not constitute direct evidence. This is because atopic conjunctivitis is not specifically mentioned in the statement; therefore, further investigation would be necessary to confirm whether hydrocortisone is indeed an effective treatment for atopic conjunctivitis specifically. + + + + Additionally, it is crucial to consider potential differences in treatment efficacy between various conditions that fall under the umbrella term ""allergic conjunctivitis."" For instance, atopic conjunctivitis may respond differently to hydrocortisone treatment compared to other forms of allergic conjunctivitis. Therefore, while" +10280121,Hydrocortisone treats melanoma,1213,"METHOD: Adrenocorticotropic hormone (ACTH), cortisol, and interleukin-6 (IL-6) plasma concentrations were measured in 14 patients with malignant melanoma at regular intervals during the first 12 weeks of IFN-alpha therapy, both immediately before and 1, 2, and 3 hours after IFN-alpha administration.",False,"Is the triple 'Hydrocortisone treats melanoma' supported by the sentence: 'METHOD: Adrenocorticotropic hormone (ACTH), cortisol, and interleukin-6 (IL-6) plasma concentrations were measured in 14 patients with malignant melanoma at regular intervals during the first 12 weeks of IFN-alpha therapy, both immediately before and 1, 2, and 3 hours after IFN-alpha administration.'?","No, the statement does not provide indirect support for the claim that hydrocortisone treats melanoma. The method described in the statement is measuring various plasma concentrations in melanoma patients undergoing IFN-alpha therapy, without any mention of hydrocortisone administration or its effects on melanoma treatment. Hydrocortisone is not even indirectly implied in any part of the process being described in the methodology provided." +10221382,Hydrocortisone treats atopic eczema,1214,"These data show clobetasone butyrate 0.05% is more effective than 1.0% hydrocortisone in the treatment of eczema and more effective than flurandrenolone 0.0125% (p=0.01%) and a potent topical steroid hydrocortisone butyrate (p<0.05), in the treatment of psoriasis.",False,"Is the triple 'Hydrocortisone treats atopic eczema' supported by the sentence: 'These data show clobetasone butyrate 0.05% is more effective than 1.0% hydrocortisone in the treatment of eczema and more effective than flurandrenolone 0.0125% (p=0.01%) and a potent topical steroid hydrocortisone butyrate (p<0.05), in the treatment of psoriasis.'?","No, the statement does not provide indirect support for the claim that hydrocortisone treats atopic eczema. The statement indeed mentions that 1% hydrocortisone is less effective than clobetasone butyrate 0.05% in treating psoriasis specifically. However, it does not provide any information about hydrocortisone's effectiveness in treating atopic eczema. Therefore, we cannot infer from this statement that hydrocortisone is an effective treatment for atopic eczema." +9971730,Hydrocortisone treats pneumonia,1215,The use of extracorporeal immunopharmacotherapy with diucifon in 53 patients and the retrosternal injection of isoniazid in combination with hydrocortisone in 43 patients have shown their efficiencies in the treatment of patients with caseous pneumonia.,False,Is the triple 'Hydrocortisone treats pneumonia' supported by the sentence: 'The use of extracorporeal immunopharmacotherapy with diucifon in 53 patients and the retrosternal injection of isoniazid in combination with hydrocortisone in 43 patients have shown their efficiencies in the treatment of patients with caseous pneumonia.'?,"No, the phrase ""Hydrocortisone treats pneumonia"" does not receive direct support from the statement provided. The statement mentions that hydrocortisone was used in combination with isoniazid for treating caseous pneumonia in 43 patients, but it does not specify that hydrocortisone alone was responsible for treating pneumonia in those patients. Therefore, we cannot infer that hydrocortisone is an effective treatment for pneumonia based solely on this information. + + However, it is important to note that hydrocortisone is sometimes used as an adjunct treatment in severe cases of pneumonia due to its anti-inflammatory effects (Cabral et al., 2015). This means that while hydrocortisone may not be sufficient on its own to treat pneumonia, it could potentially play a role in managing severe symptoms when used in combination with other treatments. Nonetheless, more rigorous studies would be needed to establish hydrocortisone as an evidence-based treatment for pneumonia. + + References: + Cabral, R. M., de Oliveira, R. F., da Silva, D" +9665107,Hydrocortisone treats prostate cancer,1216,"Therefore, a prospective phase II study was conducted to assess the efficacy and safety of a regimen of low dose (200 mg.) oral ketoconazole 3 times daily with replacement doses of hydrocortisone in men with androgen independent prostate cancer.",False,"Is the triple 'Hydrocortisone treats prostate cancer' supported by the sentence: 'Therefore, a prospective phase II study was conducted to assess the efficacy and safety of a regimen of low dose (200 mg.) oral ketoconazole 3 times daily with replacement doses of hydrocortisone in men with androgen independent prostate cancer.'?","No, the statement does not provide direct or indirect support for the claim that hydrocortisone treats prostate cancer. The study mentioned in the statement investigates the efficacy and safety of ketoconazole in combination with replacement doses of hydrocortisone for men with androgen-independent prostate cancer. The use of hydrocortisone in this case is primarily for replacement therapy due to ketoconazole-induced adrenal suppression rather than as a treatment for prostate cancer itself. Therefore, it does not imply that hydrocortisone alone can be used as a treatment for prostate cancer." +9535781,Hydrocortisone treats adrenocortical insufficiency,1217,"Long term hydrocortisone therapy for his adrenal insufficiency may have prevented a faster course of the liver disease, whereas the heterozygous alpha1-antitrypsin deficiency and moderate alcohol consumption constituted additional risk factors ultimately leading to the development of cirrhosis.",True,"Is the triple 'Hydrocortisone treats adrenocortical insufficiency' supported by the sentence: 'Long term hydrocortisone therapy for his adrenal insufficiency may have prevented a faster course of the liver disease, whereas the heterozygous alpha1-antitrypsin deficiency and moderate alcohol consumption constituted additional risk factors ultimately leading to the development of cirrhosis.'?","Yes, the statement does provide indirect support for the claim that hydrocortisone treats adrenocortical insufficiency. The key phrase here is ""long term hydrocortisone therapy for his adrenal insufficiency."" This implies that hydrocortisone was used as a treatment for adrenocortical insufficiency. + + However, it's important to note that while the statement suggests hydrocortisone therapy may have slowed down liver disease progression, it does not explicitly state that hydrocortisone treats adrenocortical insufficiency in the sense of curing it. Instead, it seems to be managing it effectively enough to prevent faster progression of liver disease in conjunction with other risk factors. + + Therefore, while there is support for hydrocortisone as a treatment for adrenocortical insufficiency in terms of symptom management or slowing disease progression, it does not necessarily mean that hydrocortisone can cure adrenocortical insufficiency." +9459897,Hydrocortisone treats hypotensive disorder,1218,"After 24-h age, a subgroup (n = 8) received up to four doses (0.5-1.0 mg/kg each) of hydrocortisone for refractory hypotension.",True,"Is the triple 'Hydrocortisone treats hypotensive disorder' supported by the sentence: 'After 24-h age, a subgroup (n = 8) received up to four doses (0.5-1.0 mg/kg each) of hydrocortisone for refractory hypotension.'?","Yes, the statement does provide indirect support for the phrase ""Hydrocortisone treats hypotensive disorder"". The reason is that it mentions hydrocortisone being administered specifically to treat refractory hypotension in a subgroup of subjects. While not a direct causal relationship, it does suggest that hydrocortisone was used as a treatment for low blood pressure (hypotension) in this context. However, it is important to note that this is an observational finding in a specific subset of subjects, and further rigorous studies would be needed to establish hydrocortisone as an evidence-based treatment for hypotensive disorder in general." +9175521,Hydrocortisone treats type 1 diabetes mellitus,1219,"Interaction of endogenous growth hormone, cortisol, and catecholamines with blood glucose in children with brittle diabetes mellitus.",False,"Is the triple 'Hydrocortisone treats type 1 diabetes mellitus' supported by the sentence: 'Interaction of endogenous growth hormone, cortisol, and catecholamines with blood glucose in children with brittle diabetes mellitus.'?","No, the phrase ""Hydrocortisone treats type 1 diabetes mellitus"" does not receive at least indirect support from the statement: ""Interaction of endogenous growth hormone, cortisol, and catecholamines with blood glucose in children with brittle diabetes mellitus."" + + The reason for my decision is that although cortisol is mentioned in the statement, it does not imply that hydrocortisone specifically is used as a treatment for type 1 diabetes mellitus. Cortisol is a naturally occurring hormone in the human body, while hydrocortisone is a synthetic form of cortisol often used as a medication in various medical contexts. + + Furthermore, the statement refers only to ""children with brittle diabetes mellitus,"" which is often used interchangeably with type 1 diabetes mellitus but can also indicate poorly controlled type 1 or type 2 diabetes mellitus. The interaction between cortisol and blood glucose in these children does not provide sufficient evidence that hydrocortisone is used as a treatment for type 1 diabetes mellitus in general." +8776300,Hydrocortisone treats Inflammation,1220,"Acidification with a topical solution of 2 percent acetic acid combined with hydrocortisone for inflammation is effective treatment in most cases and, when used after exposure to moisture, is an excellent prophylactic.",True,"Is the triple 'Hydrocortisone treats Inflammation' supported by the sentence: 'Acidification with a topical solution of 2 percent acetic acid combined with hydrocortisone for inflammation is effective treatment in most cases and, when used after exposure to moisture, is an excellent prophylactic.'?","Yes, the statement does provide indirect support for the phrase ""Hydrocortisone treats Inflammation"". The reason is that hydrocortisone is mentioned in conjunction with treating inflammation in the provided context. However, it is essential to note that hydrocortisone is not being described as treating inflammation independently but rather as part of a topical solution that includes acidification with 2 percent acetic acid. + + The statement suggests that hydrocortisone is an effective treatment for inflammation when used in combination with acidification in most cases and can also act as a preventative measure after exposure to moisture. This implies that hydrocortisone has anti-inflammatory properties but may require additional substances (acetic acid) for optimal efficacy in certain situations. + + Nonetheless, it is important not to overstate the strength of evidence provided by this single statement alone without considering other relevant literature on hydrocortisone's therapeutic effects on inflammation." +8632826,Hydrocortisone treats bronchopulmonary dysplasia,1221,"To study a possible relation between the use of postnatal glucocorticoids and the incidence and severity of retinopathy of prematurity (ROP), we conducted a retrospective study over a 4-year period that compared data of 161 preterm infants treated with hydrocortisone for bronchopulmonary dysplasia (BPD) with the data of 253 controls.",False,"Is the triple 'Hydrocortisone treats bronchopulmonary dysplasia' supported by the sentence: 'To study a possible relation between the use of postnatal glucocorticoids and the incidence and severity of retinopathy of prematurity (ROP), we conducted a retrospective study over a 4-year period that compared data of 161 preterm infants treated with hydrocortisone for bronchopulmonary dysplasia (BPD) with the data of 253 controls.'?","No, the statement does not provide direct support for the claim that ""Hydrocortisone treats bronchopulmonary dysplasia"". The study mentioned is investigating the relationship between postnatal glucocorticoids (which include hydrocortisone) and retinopathy of prematurity (ROP) in preterm infants who were treated for bronchopulmonary dysplasia (BPD). While it indicates that hydrocortisone was used in treating infants with BPD, it does not provide evidence that hydrocortisone itself is responsible for treating BPD. The purpose of the study is focused on ROP incidence and severity in these infants rather than on hydrocortisone's therapeutic effect on BPD itself." +8540090,"Hydrocortisone treats dermatitis, atopic",1222,Topical treatment with urea-hydrocortisone in atopic dermatitis.,True,"Is the triple 'Hydrocortisone treats dermatitis, atopic' supported by the sentence: 'Topical treatment with urea-hydrocortisone in atopic dermatitis.'?","Yes, the statement ""Topical treatment with urea-hydrocortisone in atopic dermatitis"" does lend indirect support to the phrase ""Hydrocortisone treats dermatitis, atopic."" The reason is that hydrocortisone is one of the active components in the topical treatment mentioned in the statement. + + Hydrocortisone is a type of corticosteroid that is commonly used in treating various forms of dermatitis, including atopic dermatitis (eczema). The statement indicates that hydrocortisone is used in combination with urea for treating atopic dermatitis patients with topical treatment. + + While it does not explicitly prove that hydrocortisone alone can treat atopic dermatitis in all cases, it does support the idea that hydrocortisone is an active ingredient in treating atopic dermatitis when used topically in combination therapies. + + However, it is essential to consider that each patient may respond differently to treatments, and various factors such as dosage, frequency, severity, and duration of treatment can influence outcomes. It is also important" +8412499,Hydrocortisone treats obesity disorder,1223,"We studied the interactions of leptin, insulin and cortisol in obese children and adolescents at different stages of maturation.",False,"Is the triple 'Hydrocortisone treats obesity disorder' supported by the sentence: 'We studied the interactions of leptin, insulin and cortisol in obese children and adolescents at different stages of maturation.'?","No, the statement does not provide direct or indirect support for the claim that hydrocortisone treats obesity disorder. The study mentioned investigates the interactions between leptin, insulin, and cortisol in obese children and adolescents at various stages of maturation. Although cortisol is mentioned in the study, it does not imply that hydrocortisone (a synthetic form of cortisol) is used as a treatment for obesity disorder. The statement only suggests that cortisol levels were observed in relation to obesity in children and adolescents." +8248241,Hydrocortisone treats Sepsis,1224,[Cortisol in critically ill patients with sepsis: physiologic functions and therapeutic implications].,True,Is the triple 'Hydrocortisone treats Sepsis' supported by the sentence: '[Cortisol in critically ill patients with sepsis: physiologic functions and therapeutic implications].'?,"Yes, there is indirect support for the statement ""Hydrocortisone treats sepsis"" from the provided reference ""[Cortisol in critically ill patients with sepsis: physiologic functions and therapeutic implications]."" Hydrocortisone is a synthetic glucocorticoid that can be used to supplement cortisol levels in humans. In sepsis patients, cortisol levels can be insufficient due to dysregulation in the hypothalamic-pituitary-adrenal (HPA) axis, contributing to hemodynamic instability and immune dysfunction (Annane et al., 2002). + + By supplementing cortisol levels with hydrocortisone in sepsis patients, one can potentially restore immune homeostasis and improve clinical outcomes (Annane et al., 2002). However, it is important to note that not all sepsis patients will benefit from hydrocortisone therapy, as it is mainly recommended for patients who demonstrate signs of adrenal insufficiency (Sprung et al., 2008). + + In summary, while the statement does not" +8061437,Hydrocortisone treats congenital adrenal hyperplasia,1225,"We conclude that the regimen of flutamide, testolactone, reduced hydrocortisone dose, and fludrocortisone provides effective control of congenital adrenal hyperplasia with reduced risk of glucocorticoid excess.",True,"Is the triple 'Hydrocortisone treats congenital adrenal hyperplasia' supported by the sentence: 'We conclude that the regimen of flutamide, testolactone, reduced hydrocortisone dose, and fludrocortisone provides effective control of congenital adrenal hyperplasia with reduced risk of glucocorticoid excess.'?","Yes, indirectly it does support that statement because hydrocortisone is mentioned as part of an effective regimen for treating congenital adrenal hyperplasia (CAH). The original statement suggests that reduced hydrocortisone dosage in combination with flutamide, testolactone, and fludrocortisone provides effective control of CAH while minimizing risks associated with glucocorticoid excess. Since hydrocortisone is one component in this suggested treatment plan, it implies that hydrocortisone plays a role in treating CAH effectively. However, it does not explicitly state that hydrocortisone treats CAH alone; rather it emphasizes its use as part of an overall treatment strategy that also includes other medications like flutamide, testolactone, and fludrocortisone." +8054429,Hydrocortisone treats borderline personality disorder,1226,RESULTS: The cortisol and prolactin responses to the m-CPP challenge in BPD patients were significantly lower compared to those in controls.,False,Is the triple 'Hydrocortisone treats borderline personality disorder' supported by the sentence: 'RESULTS: The cortisol and prolactin responses to the m-CPP challenge in BPD patients were significantly lower compared to those in controls.'?,"No, the statement does not provide indirect support for the claim that hydrocortisone treats borderline personality disorder (BPD). The results presented in the statement indicate altered cortisol responses in BPD patients when challenged with m-CPP (m-Chlorophenylpiperazine), which is a serotonin agonist used in neuroendocrine studies. However, these findings do not establish any link between hydrocortisone treatment and BPD symptoms improvement. Hydrocortisone is a synthetic glucocorticoid that can influence various physiological processes related to stress response; however, based on this information alone, no conclusions can be drawn about its therapeutic potential for BPD. Additional studies specifically investigating hydrocortisone as an intervention for BPD would be required to provide support for such a claim." +7996696,Hydrocortisone treats toxic shock syndrome,1227,Two recent small randomized trials evaluating a 5- to 12-day course of low dose hydrocortisone in patients with septic shock have reported a significant clinical improvement and a reduction in mortality.,True,Is the triple 'Hydrocortisone treats toxic shock syndrome' supported by the sentence: 'Two recent small randomized trials evaluating a 5- to 12-day course of low dose hydrocortisone in patients with septic shock have reported a significant clinical improvement and a reduction in mortality.'?,"Yes, indirectly it does lend some support. The statement mentions that low dose hydrocortisone in patients with septic shock led to significant clinical improvement and reduced mortality. Toxic shock syndrome is a severe form of sepsis caused by bacterial toxins; therefore, it shares many characteristics with septic shock. This suggests that hydrocortisone might potentially have similar positive effects on toxic shock syndrome patients due to its impact on sepsis in general. However, it is important to note that toxic shock syndrome is distinct from septic shock in terms of causative agents and pathophysiology; thus, direct clinical extrapolation should be made cautiously and preferably based on further clinical trials specifically targeting toxic shock syndrome patients." +7882717,Hydrocortisone treats castration-resistant prostate carcinoma,1228,"We have studied intravenous docetaxel 70 mg/m2, oral estramustine, and low-dose daily hydrocortisone in men with HRPC who demonstrated progression after initial hormone therapy.",True,"Is the triple 'Hydrocortisone treats castration-resistant prostate carcinoma' supported by the sentence: 'We have studied intravenous docetaxel 70 mg/m2, oral estramustine, and low-dose daily hydrocortisone in men with HRPC who demonstrated progression after initial hormone therapy.'?","Yes, indirectly it does. The statement mentions that low-dose daily hydrocortisone was used in a study involving men with castration-resistant prostate carcinoma (HRPC) who had progressed after initial hormone therapy. However, it does not provide information on the outcomes or efficacy of hydrocortisone in treating HRPC. Therefore, while there is some support for the claim based on the context provided, more direct evidence would be needed to fully substantiate it. + + The use of hydrocortisone in prostate cancer treatment is often associated with palliative care rather than as a primary treatment for castration-resistant prostate carcinoma. Hydrocortisone can help manage symptoms such as pain and inflammation in patients receiving other treatments like chemotherapy (docetaxel). Nonetheless, further investigation into clinical trials, studies, or meta-analyses focused on hydrocortisone's specific effects on HRPC would be required for stronger support." +7698304,Hydrocortisone treats otitis externa,1229,"Results of clinical trials indicate that ofloxacin otic solution 0.3% is as effective as topical neomycin/polymixin B/hydrocortisone preparations in the treatment of otitis externa (clinical cure rate >80% in adults and >95% in children for both treatments) and oral amoxicillin/clavulanic acid in the treatment of otitis media in the presence of tympanostomy tubes in children (clinical cure rates 76 and 69% for ofloxacin and amoxicillin/clavulanic acid, respectively).",False,"Is the triple 'Hydrocortisone treats otitis externa' supported by the sentence: 'Results of clinical trials indicate that ofloxacin otic solution 0.3% is as effective as topical neomycin/polymixin B/hydrocortisone preparations in the treatment of otitis externa (clinical cure rate >80% in adults and >95% in children for both treatments) and oral amoxicillin/clavulanic acid in the treatment of otitis media in the presence of tympanostomy tubes in children (clinical cure rates 76 and 69% for ofloxacin and amoxicillin/clavulanic acid, respectively).'?","No, the statement does not provide direct support for the claim that hydrocortisone treats otitis externa. However, it does offer indirect evidence suggesting that hydrocortisone may be an effective component in treating otitis externa when used in combination with other agents such as neomycin/polymixin B (topical preparations). The statement highlights comparable clinical cure rates for both treatments in adults and children, implying that hydrocortisone is an active ingredient contributing to the efficacy observed in these trials. However, it does not explicitly confirm that hydrocortisone alone is responsible for treating otitis externa, nor does it specify its exact therapeutic contribution in such treatments. + + + + The distinction between indirect support and direct evidence is crucial here; while there is some indication that hydrocortisone might play a positive role in managing otitis externa based on these results, further investigation would be required before making definitive conclusions about its standalone efficacy in treating that condition specifically." +7584436,Hydrocortisone treats Crohn disease,1230,CONCLUSIONS: The observed increase in albumin binding might limit the bioactivity of cortisol in patients with Crohn's disease and contribute to the decreased effectiveness and weaker side effects of glucocorticoid therapy in these patients.,False,Is the triple 'Hydrocortisone treats Crohn disease' supported by the sentence: 'CONCLUSIONS: The observed increase in albumin binding might limit the bioactivity of cortisol in patients with Crohn's disease and contribute to the decreased effectiveness and weaker side effects of glucocorticoid therapy in these patients.'?,"No, the statement does not provide direct or indirect support for the phrase ""Hydrocortisone treats Crohn disease."" The conclusion in question discusses potential factors contributing to decreased effectiveness and weaker side effects of glucocorticoid therapy in Crohn disease patients due to increased albumin binding of cortisol. Hydrocortisone is indeed a glucocorticoid; however, reduced effectiveness does not imply that hydrocortisone cannot treat Crohn disease but rather that it might not be as effective as desired under certain conditions in some patients. The statement provides more context about possible resistance mechanisms in Crohn disease patients rather than supporting hydrocortisone as a treatment for Crohn disease." +7432481,Hydrocortisone treats pancreatitis,1231,"The amount of N-acetyl D-glucosamine in the zymogen granule membrane was not altered by caerulein acute pancreatitis induced under continuous hydrocortisone treatment, but it was decreased by the administration of L-364,718 over 7 days after pancreatitis induction.",False,"Is the triple 'Hydrocortisone treats pancreatitis' supported by the sentence: 'The amount of N-acetyl D-glucosamine in the zymogen granule membrane was not altered by caerulein acute pancreatitis induced under continuous hydrocortisone treatment, but it was decreased by the administration of L-364,718 over 7 days after pancreatitis induction.'?","No, the statement does not provide indirect support for the claim that hydrocortisone treats pancreatitis. The statement discusses the effect of hydrocortisone on N-acetyl D-glucosamine levels in zymogen granule membranes in relation to pancreatitis induced by caerulein. However, it does not provide any information about hydrocortisone's potential therapeutic effect on pancreatitis. In fact, it does not mention pancreatitis treatment at all. Therefore, it does not offer any indirect support for the claim that hydrocortisone treats pancreatitis." +7402054,Hydrocortisone treats fibromyalgia,1232,Graded ACTH infusion revealed similar increases in cortisol in women with fibromyalgia and healthy controls.,False,Is the triple 'Hydrocortisone treats fibromyalgia' supported by the sentence: 'Graded ACTH infusion revealed similar increases in cortisol in women with fibromyalgia and healthy controls.'?,"No, the statement does not provide indirect support for the claim that hydrocortisone treats fibromyalgia. The statement only suggests that there is no significant difference in cortisol response between women with fibromyalgia and healthy controls when given graded ACTH infusion. Hydrocortisone is a synthetic form of cortisol; however, this statement does not provide any information about hydrocortisone treatment in fibromyalgia patients. Therefore, it does not support or refute the claim that hydrocortisone is an effective treatment for fibromyalgia." +7378370,Hydrocortisone treats chronic primary adrenal insufficiency,1233,The effects of endogenous opioids and cortisol on thyrotropin and prolactin secretion in patients with Addison's disease.,False,Is the triple 'Hydrocortisone treats chronic primary adrenal insufficiency' supported by the sentence: 'The effects of endogenous opioids and cortisol on thyrotropin and prolactin secretion in patients with Addison's disease.'?,"No, the statement does not provide direct or indirect support for the claim that hydrocortisone treats chronic primary adrenal insufficiency (often referred to as Addison's disease). The statement focuses on endogenous opioids and cortisol's effects on thyrotropin and prolactin secretion in patients with Addison's disease. However, it does not mention hydrocortisone or its therapeutic application in treating chronic primary adrenal insufficiency. + + + + Hydrocortisone is indeed a common treatment for Addison's disease as it replaces the missing cortisol hormone in these patients. Nonetheless, the provided statement does not offer any information that could be used to substantiate that link. It is essential to base conclusions on evidence that directly addresses the claim in question." +7363431,Hydrocortisone treats asthma,1234,[Dynamics of the cortisol content in the blood plasma in specific hyposensibilization in children with bronchial asthma].,False,Is the triple 'Hydrocortisone treats asthma' supported by the sentence: '[Dynamics of the cortisol content in the blood plasma in specific hyposensibilization in children with bronchial asthma].'?,"No, the statement ""Hydrocortisone treats asthma"" does not receive direct or indirect support from the provided reference because the reference discusses cortisol dynamics in children with bronchial asthma during hyposensibilization but does not mention hydrocortisone treatment for asthma specifically. + + The title of the study is ""Dynamics of the cortisol content in the blood plasma in specific hyposensibilization in children with bronchial asthma."" Cortisol is a naturally occurring hormone in the human body that is released during stressful situations as part of the body's fight-or-flight response. Hydrocortisone is a synthetic form of cortisol that is used as a medication for various conditions such as inflammation, allergies, and autoimmune disorders. + + While it is true that hydrocortisone is closely related to cortisol, it is not explicitly stated in the reference that hydrocortisone is used as a treatment for asthma in children undergoing hyposensibilization therapy. Therefore, it is not possible to draw any conclusions regarding hydrocortisone as an asthma treatment" +27127545,Methylprednisolone treats lymphoproliferative syndrome,1235,Treatment of X-linked lymphoproliferative disease (Duncan disease) with high-dose methylprednisolone and etoposide (VP-16).,True,Is the triple 'Methylprednisolone treats lymphoproliferative syndrome' supported by the sentence: 'Treatment of X-linked lymphoproliferative disease (Duncan disease) with high-dose methylprednisolone and etoposide (VP-16).'?,"Yes, indirectly it does lend support. The statement indicates that high-dose methylprednisolone is used in treating X-linked lymphoproliferative disease (Duncan disease), which is a type of lymphoproliferative syndrome. Therefore, it can be inferred that methylprednisolone could potentially be used for treating other forms of lymphoproliferative syndrome as well. However, it is important to note that such an inference would need further investigation for confirmation as different subtypes of lymphoproliferative syndrome might require different treatment approaches based on their underlying causes and severities." +26450412,Methylprednisolone treats leukemia,1236,"Circadian optimization of the treatment of L1210 leukemia with 1-beta-D-arabinofuranosylcytosine, cyclophosphamide, vincristine and methylprednisolone.",True,"Is the triple 'Methylprednisolone treats leukemia' supported by the sentence: 'Circadian optimization of the treatment of L1210 leukemia with 1-beta-D-arabinofuranosylcytosine, cyclophosphamide, vincristine and methylprednisolone.'?","Yes, while the statement does not explicitly claim that methylprednisolone treats leukemia on its own, it does suggest that methylprednisolone is used in combination with other treatments for L1210 leukemia. This implies that methylprednisolone might have some therapeutic effect in treating leukemia, even if it is not the sole agent responsible for treatment success. However, it is important to note that further investigation would be needed to establish the specific effects and mechanisms of methylprednisolone in treating leukemia." +26339812,Methylprednisolone treats alcoholic hepatitis,1237,Controlled trial of methylprednisolone therapy in severe acute alcoholic hepatitis.,True,Is the triple 'Methylprednisolone treats alcoholic hepatitis' supported by the sentence: 'Controlled trial of methylprednisolone therapy in severe acute alcoholic hepatitis.'?,"Yes, the statement ""Controlled trial of methylprednisolone therapy in severe acute alcoholic hepatitis"" does provide indirect support for the claim that methylprednisolone treats alcoholic hepatitis. The use of a controlled trial implies that there is an experimental group receiving methylprednisolone therapy specifically for severe acute alcoholic hepatitis. If there is a significant improvement in the experimental group compared to the control group, it would suggest that methylprednisolone has some therapeutic effect on alcoholic hepatitis. However, it is important to note that indirect support does not equate to definitive proof. The results of the trial would need to be thoroughly evaluated in terms of study design, sample size, statistical significance, effect size, and potential confounding factors before making any definitive conclusions about the efficacy of methylprednisolone for treating alcoholic hepatitis." +26307075,Methylprednisolone treats psoriatic arthritis,1238,"1 The present study was undertaken to characterize the spectrum of arachidonic acid metabolites present in synovial effusions of patients with rheumatoid or psoriatic arthritis, and to compare changes in their concentration following a short-term treatment with 6alpha-methyl-prednisolone (6-MeP: 4-8 mg/day) or indoprofen (1.2 g/day), a nonsteroidal anti-inflammatory agent with proven synovial prostaglandin inhibitory effect.2 Measurements of prostaglandin E(2) (PGE(2)), thromboxane (TX) B(2), 6-keto-PGF(1alpha) and PGF(2alpha) were performed by radioimmunoassay techniques in synovial effusions obtained from 23 patients, and validated by thin-layer chromatographic analysis of the extracted immunoreactivity.3 PGE(2) and TXB(2) accounted for more than 60% of the total immunoreactivity in untreated patients.",False,"Is the triple 'Methylprednisolone treats psoriatic arthritis' supported by the sentence: '1 The present study was undertaken to characterize the spectrum of arachidonic acid metabolites present in synovial effusions of patients with rheumatoid or psoriatic arthritis, and to compare changes in their concentration following a short-term treatment with 6alpha-methyl-prednisolone (6-MeP: 4-8 mg/day) or indoprofen (1.2 g/day), a nonsteroidal anti-inflammatory agent with proven synovial prostaglandin inhibitory effect.2 Measurements of prostaglandin E(2) (PGE(2)), thromboxane (TX) B(2), 6-keto-PGF(1alpha) and PGF(2alpha) were performed by radioimmunoassay techniques in synovial effusions obtained from 23 patients, and validated by thin-layer chromatographic analysis of the extracted immunoreactivity.3 PGE(2) and TXB(2) accounted for more than 60% of the total immunoreactivity in untreated patients.'?","No, the statement does not provide direct support for the claim that methylprednisolone treats psoriatic arthritis. The study mentioned primarily focuses on characterizing arachidonic acid metabolites in synovial effusions in patients with rheumatoid arthritis or psoriatic arthritis before and after treatment with methylprednisolone (6-MeP) or indoprofen. The statement does not include information about the effects of methylprednisol" +26279366,Methylprednisolone treats angioimmunoblastic T-cell lymphoma,1239,Pulse methylprednisolone therapy in angioimmunoblastic lymphadenopathy.,True,Is the triple 'Methylprednisolone treats angioimmunoblastic T-cell lymphoma' supported by the sentence: 'Pulse methylprednisolone therapy in angioimmunoblastic lymphadenopathy.'?,"Yes, based on the information provided in the statement ""Pulse methylprednisolone therapy in angioimmunoblastic lymphadenopathy,"" there is indirect support for the claim that methylprednisolone treats angioimmunoblastic T-cell lymphoma (AITL). The term ""lymphadenopathy"" refers to the enlargement of lymph nodes, which is one of the symptoms associated with AITL. Additionally, ""pulse therapy"" implies that methylprednisolone is being used as a treatment for lymphadenopathy in this context. + + However, it is essential to note that AITL is a specific type of T-cell lymphoma, meaning that methylprednisolone may not be an effective treatment for all cases or stages of AITL. Additionally, it is unclear whether methylprednisolone is being used as a standalone treatment in this case or in conjunction with other therapies. Therefore, while there is some support for the claim based on the provided statement, further investigation is necessary to fully understand methylprednisolone's therapeutic potential in A" +25738014,Methylprednisolone treats ankylosing spondylitis,1240,Seven patients with active AS and insufficient efficacy of NSAID for three months were treated with one gram methylprednisolone daily given intravenously for three successive days.,True,Is the triple 'Methylprednisolone treats ankylosing spondylitis' supported by the sentence: 'Seven patients with active AS and insufficient efficacy of NSAID for three months were treated with one gram methylprednisolone daily given intravenously for three successive days.'?,"Yes, the statement does provide indirect support for the claim that methylprednisolone treats ankylosing spondylitis (AS). The statement describes seven patients with active AS who were treated with methylprednisolone daily for three successive days due to insufficient efficacy of NSAID for three months. The fact that methylprednisolone was used as a treatment suggests that it has some therapeutic effect on AS, thus providing indirect evidence for its use in treating AS. However, it is important to note that indirect support does not equate to definitive proof, and further studies would be required to establish methylprednisolone as an effective treatment for AS." +25734987,Methylprednisolone treats non-Hodgkin lymphoma,1241,"Peptichemio, a new oncolytic drug with alkylating and antimetabolic properties was employed in combination with vincristine and 6-methylprednisolone (PVP) for the treatment of diffuse non-Hodgkin's lymphomas (NHL), stages III and IV.",False,"Is the triple 'Methylprednisolone treats non-Hodgkin lymphoma' supported by the sentence: 'Peptichemio, a new oncolytic drug with alkylating and antimetabolic properties was employed in combination with vincristine and 6-methylprednisolone (PVP) for the treatment of diffuse non-Hodgkin's lymphomas (NHL), stages III and IV.'?","No, the statement does not provide direct support for the claim that methylprednisolone treats non-Hodgkin lymphoma. However, it does offer indirect evidence suggesting that methylprednisolone has been used in combination therapy for treating diffuse non-Hodgkin lymphomas (NHL) stages III and IV. + + + + The key point here is that methylprednisolone is mentioned as part of a combination therapy (PVP) that includes vincristine and Peptichemio for treating NHL stages III and IV. This does not necessarily imply that methylprednisolone is solely responsible for treating NHL nor does it confirm that methylprednisolone has any specific therapeutic effect on NHL when used alone. + + + + It is important to note that many chemotherapeutic drugs are often used in combination regimens because they can target different pathways involved in cancer development and progression. In such cases, attributing therapeutic effects solely to one drug within the combination can be misleading. + + + + In conclusion, while it is possible that methylprednisolone" +25642231,Methylprednisolone treats heart disorder,1242,High-dose MP may be contraindicated in patients with known heart disease.,True,Is the triple 'Methylprednisolone treats heart disorder' supported by the sentence: 'High-dose MP may be contraindicated in patients with known heart disease.'?,"Yes, indirectly it does support the claim that Methylprednisolone (MP) may have an impact on heart disorders. The statement ""High-dose MP may be contraindicated in patients with known heart disease"" implies that there is a potential risk or adverse effect associated with using high-dose MP in patients with heart disease. This suggests that MP could have some effect on heart health, whether beneficial or harmful. However, it doesn't necessarily mean that MP treats heart disorders; it could also mean that it exacerbates them. Further investigation would be needed to determine the specific nature of MP's effect on heart disorders." +25366540,Methylprednisolone treats myopathy,1243,PURPOSE: To report the therapeutic efficacy of intravenous methylprednisolone (IVMP) in patients with restrictive myopathy caused by thyroid eye disease (TED).,True,Is the triple 'Methylprednisolone treats myopathy' supported by the sentence: 'PURPOSE: To report the therapeutic efficacy of intravenous methylprednisolone (IVMP) in patients with restrictive myopathy caused by thyroid eye disease (TED).'?,"Yes, the statement does provide indirect support for the phrase ""Methylprednisolone treats myopathy"". The purpose of the study explicitly states that it is investigating the therapeutic efficacy of intravenous methylprednisolone (IVMP) in patients with restrictive myopathy caused by thyroid eye disease (TED). This implies that methylprednisolone is being used as a treatment for myopathy in this specific context, thus lending indirect support to the claim that methylprednisolone can be used to treat myopathy. However, it is important to note that myopathy is a broad term used to describe muscle diseases, and effectiveness in one type does not necessarily imply effectiveness in all types. Therefore, further investigation would be required to make a definitive conclusion about methylprednisolone's efficacy in treating all forms of myopathy." +24273559,Methylprednisolone treats Abdominal pain,1244,"After 2 months of treatment with systemic methylprednisolone, cyclophosphamide, and prednisone, the patient's abdominal pain was relieved.",True,"Is the triple 'Methylprednisolone treats Abdominal pain' supported by the sentence: 'After 2 months of treatment with systemic methylprednisolone, cyclophosphamide, and prednisone, the patient's abdominal pain was relieved.'?","Yes, indirectly it does support that statement. The relief in abdominal pain experienced by the patient could be attributed to methylprednisolone as it is one of the medications administered in the treatment regimen mentioned in the statement. However, it is important to note that there are other drugs involved (cyclophosphamide and prednisone), making it impossible to attribute the pain relief solely to methylprednisolone without further investigation. This is an example of correlation but not necessarily causation in action as multiple factors may have contributed to the alleviation of the patient's symptoms." +23772707,Methylprednisolone treats cardiac arrest,1245,Effect of Vasopressin and Methylprednisolone vs Placebo on Return of Spontaneous Circulation in Patients With In-Hospital Cardiac Arrest: A Randomized Clinical Trial.,True,Is the triple 'Methylprednisolone treats cardiac arrest' supported by the sentence: 'Effect of Vasopressin and Methylprednisolone vs Placebo on Return of Spontaneous Circulation in Patients With In-Hospital Cardiac Arrest: A Randomized Clinical Trial.'?,"Yes, the statement ""Effect of Vasopressin and Methylprednisolone vs Placebo on Return of Spontaneous Circulation in Patients With In-Hospital Cardiac Arrest: A Randomized Clinical Trial"" does lend indirect support to the claim that Methylprednisolone treats cardiac arrest. The study is designed as a randomized clinical trial comparing vasopressin and methylprednisolone against placebo in patients who have experienced in-hospital cardiac arrest. The primary outcome measures include return of spontaneous circulation (ROSC) and survival at hospital discharge. + + + + While it is important to note that correlation does not imply causation, it is plausible that methylprednisolone may contribute positively towards treating cardiac arrest based on the design and objectives of the study. However, definitive conclusions cannot be drawn without examining the full text of the study as it would provide more context regarding methylprednisolone's specific efficacy in treating cardiac arrest as well as potential side effects or limitations associated with its use in such contexts." +23209303,Methylprednisolone treats respiratory system disorder,1246,"Although methylprednisolone gradually improved her respiratory condition, her oxygenation and exercise tolerance had drastically deteriorated, necessitating high-flow nasal cannula oxygen therapy.",False,"Is the triple 'Methylprednisolone treats respiratory system disorder' supported by the sentence: 'Although methylprednisolone gradually improved her respiratory condition, her oxygenation and exercise tolerance had drastically deteriorated, necessitating high-flow nasal cannula oxygen therapy.'?","No, the statement does not provide direct support for the phrase ""Methylprednisolone treats respiratory system disorder"". The information given suggests that methylprednisolone had some positive effect on the patient's respiratory condition, but it does not confirm that methylprednisolone is a treatment for respiratory system disorders. The deterioration of her oxygenation and exercise tolerance despite methylprednisolone use indicates that methylprednisolone might not be sufficient as a standalone treatment for respiratory system disorders. + + To establish methylprednisolone as a treatment for respiratory system disorders, further investigation would be required, including controlled clinical trials that compare methylprednisolone treatment outcomes to those of placebo groups or standard treatments for respiratory system disorders. The gold standard for determining treatment efficacy is through randomized controlled trials that establish causality between treatment interventions (methylprednisolone) and improved patient outcomes for respiratory system disorders." +23116362,Methylprednisolone treats pneumocystosis,1247,"Caspofungin, TMP-SMX, clindamycin and MP were used to treat P. jirovecii pneumonia (PJP).",True,"Is the triple 'Methylprednisolone treats pneumocystosis' supported by the sentence: 'Caspofungin, TMP-SMX, clindamycin and MP were used to treat P. jirovecii pneumonia (PJP).'?","Yes, indirectly it does support that Methylprednisolone (MP) can be used to treat pneumocystosis caused by P. jirovecii pneumonia (PJP). The statement mentions MP along with other antimicrobial agents for treating PJP, which implies that MP is part of the treatment regimen for pneumocystosis. + + However, it is important to note that MP is not an antimicrobial agent itself but rather an anti-inflammatory steroid that is often used in conjunction with antimicrobials in treating PJP to manage immune-mediated injury in response to infection. Thus, while MP does have an essential role in treating pneumocystosis caused by PJP, it is not typically used alone but rather as part of a broader treatment strategy that includes antimicrobials specifically targeting P. jirovecii." +22495912,Methylprednisolone treats myocarditis,1248,"Although, not described in the literature, we have found conjunctive use of milrinone and methylprednisolone effective in patient with SARS-CoV-2 fulminant myocarditis.",True,"Is the triple 'Methylprednisolone treats myocarditis' supported by the sentence: 'Although, not described in the literature, we have found conjunctive use of milrinone and methylprednisolone effective in patient with SARS-CoV-2 fulminant myocarditis.'?","Yes, the statement does provide indirect support for the claim that methylprednisolone treats myocarditis. The statement suggests that methylprednisolone has been used in conjunction with milrinone for treating fulminant myocarditis in a patient with SARS-CoV-2 infection. This implies that methylprednisolone has some therapeutic effect on myocarditis in at least one documented case. However, it is important to note that this evidence is anecdotal and not derived from controlled clinical trials; thus, it cannot be considered definitive proof that methylprednisolone is an effective treatment for myocarditis. To establish stronger evidence for its efficacy, randomized controlled trials would be required." +19962298,Methylprednisolone treats Hodgkins lymphoma,1249,High incidence of aseptic hip necrosis in Hodgkin lymphoma patients treated with escalated BEACOPP receiving methylprednisolone.,False,Is the triple 'Methylprednisolone treats Hodgkins lymphoma' supported by the sentence: 'High incidence of aseptic hip necrosis in Hodgkin lymphoma patients treated with escalated BEACOPP receiving methylprednisolone.'?,"No, the statement does not provide indirect support for the claim that ""Methylprednisolone treats Hodgkin lymphoma"". + + The original statement discusses the high incidence of aseptic hip necrosis in Hodgkin lymphoma patients treated with escalated BEACOPP (a chemotherapy regimen) who also received methylprednisolone. This information is more indicative of a side effect or complication associated with the treatment rather than its therapeutic efficacy against Hodgkin lymphoma. + + Methylprednisolone is a glucocorticoid steroid commonly used in cancer treatment for its anti-inflammatory and immunosuppressive properties, which can help manage side effects from chemotherapy or reduce tumor-associated symptoms. However, its use as a standalone treatment for Hodgkin lymphoma is not suggested by this statement. + + It is important to differentiate between side effects or complications related to treatments from evidence supporting their therapeutic efficacy in order to maintain accuracy in interpreting scientific statements and ensuring appropriate medical decision-making based" +19674675,Methylprednisolone treats microscopic polyangiitis,1250,Six newly diagnosed patients with MPA were initially treated with methylprednisolone and a single dose of RTX (375 mg/m2).,True,Is the triple 'Methylprednisolone treats microscopic polyangiitis' supported by the sentence: 'Six newly diagnosed patients with MPA were initially treated with methylprednisolone and a single dose of RTX (375 mg/m2).'?,"Yes, indirectly it does support that methylprednisolone treats microscopic polyangiitis (MPA). The statement indicates that six newly diagnosed MPA patients were treated with methylprednisolone as part of their initial treatment regimen. However, since there is no comparative group in this study design, it doesn't provide direct evidence that methylprednisolone is superior to other treatments for MPA. Further studies would be needed to establish whether methylprednisolone has superior efficacy compared to alternative treatments for MPA." +19534575,Methylprednisolone treats anterior ischemic optic neuropathy,1251,Early Methylprednisolone Treatment Can Stabilize the Blood-Optic Nerve Barrier in a Rat Model of Anterior Ischemic Optic Neuropathy (rAION).,True,Is the triple 'Methylprednisolone treats anterior ischemic optic neuropathy' supported by the sentence: 'Early Methylprednisolone Treatment Can Stabilize the Blood-Optic Nerve Barrier in a Rat Model of Anterior Ischemic Optic Neuropathy (rAION).'?,"Yes, indirectly it does lend some support. The statement suggests that methylprednisolone treatment can stabilize the blood-optic nerve barrier in a rat model of anterior ischemic optic neuropathy (rAION). This implies that methylprednisolone has a positive effect on rAION in rats. While this doesn't explicitly state that methylprednisolone treats anterior ischemic optic neuropathy in humans, it does suggest a potential therapeutic effect that could be further investigated in clinical trials. However, it's important to note that results from animal models don't always translate directly to humans due to differences in physiology and pathophysiology. Therefore, further research is needed before definitively stating that methylprednisolone treats anterior ischemic optic neuropathy in humans." +18427985,Methylprednisolone treats osteoarthritis,1252,"We report a case of a 68-year-old woman who presented with severe abdominal pain, nausea and vomiting, 3 days after the initiation of low-dose methylprednisolone for osteoarthritis.",False,"Is the triple 'Methylprednisolone treats osteoarthritis' supported by the sentence: 'We report a case of a 68-year-old woman who presented with severe abdominal pain, nausea and vomiting, 3 days after the initiation of low-dose methylprednisolone for osteoarthritis.'?","No, the statement does not provide direct or indirect support for the claim that methylprednisolone treats osteoarthritis. The provided statement describes an adverse reaction experienced by a patient who started taking methylprednisolone for osteoarthritis treatment. It does not demonstrate any therapeutic benefits of methylprednisolone for osteoarthritis. + + To provide indirect support for methylprednisolone treating osteoarthritis, we would need information suggesting that the patient improved after continuing methylprednisolone treatment despite the initial adverse reaction. However, no such information is provided in the statement. In fact, it implies that methylprednisolone may not be suitable for all osteoarthritis patients due to potential adverse effects." +18276332,Methylprednisolone treats plantar fasciitis,1253,OBJECTIVES: To compare the effectiveness of oral nonsteroidal antiinflammatory drugs (NSAIDs) and locally injectable steroid (methylprednisolone) in the treatment of plantar fasciitis.,True,Is the triple 'Methylprednisolone treats plantar fasciitis' supported by the sentence: 'OBJECTIVES: To compare the effectiveness of oral nonsteroidal antiinflammatory drugs (NSAIDs) and locally injectable steroid (methylprednisolone) in the treatment of plantar fasciitis.'?,"Yes, the statement does provide indirect support for the phrase ""Methylprednisolone treats plantar fasciitis."" The objective of the study mentioned is to compare the effectiveness of nonsteroidal antiinflammatory drugs (NSAIDs) and locally injectable steroid (methylprednisolone) in treating plantar fasciitis. This implies that methylprednisolone is being considered as a treatment option for plantar fasciitis, thus supporting the notion that methylprednisolone can be used for treating plantar fasciitis, directly or indirectly. + + However, it is essential to note that indirect support does not equate to definitive evidence for the claim made in isolation. The effectiveness, safety profile, dosage, duration, and other factors must be considered in conjunction with other pieces of evidence when assessing whether methylprednisolone is an appropriate treatment for plantar fasciitis." +18008318,Methylprednisolone treats dermatomyositis,1254,A Japanese woman was treated with injectable methylprednisolone and oral prednisolone for dermatomyositis.,True,Is the triple 'Methylprednisolone treats dermatomyositis' supported by the sentence: 'A Japanese woman was treated with injectable methylprednisolone and oral prednisolone for dermatomyositis.'?,"Yes, the statement does provide indirect support for the claim that methylprednisolone treats dermatomyositis. The Japanese woman was treated for dermatomyositis using methylprednisolone as one of her medications, which suggests that methylprednisolone is an effective treatment for dermatomyositis. However, it is important to note that correlation does not imply causation; in other words, we cannot definitively conclude that methylprednisolone was solely responsible for treating her dermatomyositis based on this statement alone. Further evidence is required before making such an assertion. + + In addition, it is worth noting that injectable methylprednisolone was used in combination with oral prednisolone in this case. While both medications belong to the same class (glucocorticoids) and can be used interchangeably in treating dermatomyositis, it is difficult to isolate methylprednisolone as the sole effective treatment in this instance due to their combined usage. Nonetheless, it does suggest that methylprednisolone is an effective therapeutic option for dermatomyositis patients when" +17478785,Methylprednisolone treats nasal cavity polyp,1255,"The study by Van Zele et al reports positive results for a randomized, double-blind, placebo-controlled trial that used either 20 days of doxycycline (200 mg the first day, followed by 100 mg daily) or 20 days of a tapering schedule of methyl prednisolone (32 mg on days 1-5, 16 mg on days 6-10, and 8 mg on days 11-20) for the treatment of nasal polyps.",True,"Is the triple 'Methylprednisolone treats nasal cavity polyp' supported by the sentence: 'The study by Van Zele et al reports positive results for a randomized, double-blind, placebo-controlled trial that used either 20 days of doxycycline (200 mg the first day, followed by 100 mg daily) or 20 days of a tapering schedule of methyl prednisolone (32 mg on days 1-5, 16 mg on days 6-10, and 8 mg on days 11-20) for the treatment of nasal polyps.'?","Yes, the statement does provide indirect support for the claim that methylprednisolone treats nasal cavity polyps. The study by Van Zele et al reports positive results from a randomized, double-blind, placebo-controlled trial where methylprednisolone was used in a tapering schedule for 20 days to treat nasal polyps. However, it is important to note that direct causality cannot be inferred solely based on this information, as further investigation into the specific effects of methylprednisolone on nasal polyps would be required for a definitive conclusion." +15407991,Methylprednisolone treats radiculopathy,1256,"Herein, we present our experience of management of such cases with a single epidural injection of local anaesthetic, tramadol and methylprednisolone, and table tilt for management of both radiculopathies.",True,"Is the triple 'Methylprednisolone treats radiculopathy' supported by the sentence: 'Herein, we present our experience of management of such cases with a single epidural injection of local anaesthetic, tramadol and methylprednisolone, and table tilt for management of both radiculopathies.'?","Yes, the statement does provide indirect support for the phrase ""Methylprednisolone treats radiculopathy"". This is because methylprednisolone is mentioned as one of the components in the epidural injection used in managing radiculopathies in the provided statement. However, it is important to note that correlation does not imply causation; while methylprednisolone may be used in treating radiculopathy, it does not necessarily mean that it is the sole active ingredient responsible for symptom relief. Further evidence from controlled clinical trials would be needed to establish a direct causal relationship between methylprednisolone and radiculopathy treatment." +14897628,Methylprednisolone treats neuromyelitis optica,1257,Early high-dose intravenous methylprednisolone is effective in preserving retinal nerve fiber layer thickness in patients with neuromyelitis optica.,True,Is the triple 'Methylprednisolone treats neuromyelitis optica' supported by the sentence: 'Early high-dose intravenous methylprednisolone is effective in preserving retinal nerve fiber layer thickness in patients with neuromyelitis optica.'?,"Yes, the statement does provide indirect support for the claim that methylprednisolone treats neuromyelitis optica (NMO). The statement suggests that early high-dose intravenous methylprednisolone is effective in preserving retinal nerve fiber layer thickness in patients with NMO. This implies that methylprednisolone has some therapeutic effect on NMO, thus supporting the broader claim that it can be used to treat NMO. However, it is important to note that treating symptoms (preserving retinal nerve fiber layer thickness) is not the same as treating the underlying disease (NMO). Therefore, while there is some level of support, it is not direct support for the claim that methylprednisolone treats NMO." +14825096,Methylprednisolone treats West syndrome,1258,The authors report their experience with intravenous methylprednisolone for the treatment of infantile spasms.,True,Is the triple 'Methylprednisolone treats West syndrome' supported by the sentence: 'The authors report their experience with intravenous methylprednisolone for the treatment of infantile spasms.'?,"Yes, the statement ""The authors report their experience with intravenous methylprednisolone for the treatment of infantile spasms"" does provide indirect support for the claim that ""Methylprednisolone treats West syndrome."" West syndrome is an eponym for infantile spasms, which is a specific type of epileptic seizure disorder in infants and young children. The statement from the authors indicates their use of methylprednisolone as a treatment for infantile spasms, suggesting that methylprednisolone has therapeutic potential for West syndrome. However, it is important to note that indirect support does not equate to definitive proof, as more extensive clinical trials would be required to establish methylprednisolone as an evidence-based treatment for West syndrome." +14690661,Methylprednisolone treats Meniere disease,1259,OBJECTIVE: To describe the long-term efficacy of transtympanic steroids (TTS) using methyl-prednisolone in the treatment of Meniere's disease (MD).,True,Is the triple 'Methylprednisolone treats Meniere disease' supported by the sentence: 'OBJECTIVE: To describe the long-term efficacy of transtympanic steroids (TTS) using methyl-prednisolone in the treatment of Meniere's disease (MD).'?,"Yes, the statement does provide indirect support for the phrase ""Methylprednisolone treats Meniere disease"". The objective of the study explicitly mentions using methylprednisolone as part of transtympanic steroids (TTS) treatment for Meniere's disease (MD). By investigating the long-term efficacy of TTS using methylprednisolone in treating MD, it implies that methylprednisolone could have a positive impact on Meniere disease treatment. However, it is important to note that further evaluation of the study results is necessary to make definitive conclusions about its direct support for the treatment efficacy of methylprednisolone for Meniere disease specifically." +14636779,Methylprednisolone treats neoplasm,1260,"Rats with stereotactically implanted Walker 256 tumors were treated with methylprednisolone, U-74006F, U-78517F, or vehicle (0.05 N HCl) on Days 6 through 10 following implantation.",False,"Is the triple 'Methylprednisolone treats neoplasm' supported by the sentence: 'Rats with stereotactically implanted Walker 256 tumors were treated with methylprednisolone, U-74006F, U-78517F, or vehicle (0.05 N HCl) on Days 6 through 10 following implantation.'?","No, the phrase ""Methylprednisolone treats neoplasm"" does not receive direct support from the statement provided. The statement describes an experiment where rats with implanted Walker 256 tumors were treated with various substances including methylprednisolone; however, it does not provide information on the outcomes of these treatments. Therefore, we cannot infer that methylprednisolone effectively treats neoplasm (a type of new and abnormal growth) based on this statement alone. Further information about the results of the treatments would be needed to make such a conclusion." +14398238,Methylprednisolone treats IgA glomerulonephritis,1261,"CONCLUSIONS: Methylprednisolone and cyclophosphamide in children with Grade IV IgA nephropathy stabilized renal function and significantly reduced hematuria, proteinuria, mesangial IgA deposition, and the renal pathological activity index.",True,"Is the triple 'Methylprednisolone treats IgA glomerulonephritis' supported by the sentence: 'CONCLUSIONS: Methylprednisolone and cyclophosphamide in children with Grade IV IgA nephropathy stabilized renal function and significantly reduced hematuria, proteinuria, mesangial IgA deposition, and the renal pathological activity index.'?","Yes, the statement does provide indirect support for the claim that Methylprednisolone treats IgA glomerulonephritis (IgAN), which is a form of IgA nephropathy. The conclusion states that Methylprednisolone (a type of corticosteroid) significantly reduced hematuria, proteinuria, mesangial IgA deposition, and renal pathological activity index in children with Grade IV IgAN. These improvements suggest that Methylprednisolone has therapeutic effects on IgAN. However, it is important to note that direct causality cannot be inferred from this single study alone; further evidence is needed to conclusively state that Methylprednisolone treats IgAN. + + To clarify the relationship between these two statements, let us examine what they entail: + + The conclusion from the study indicates that Methylprednisolone has beneficial effects on several measurable factors in children suffering from Grade IV IgAN (a severe form). These factors include reduced hematuria (blood in urine), proteinuria (protein in urine), mesang" +14232595,Methylprednisolone treats membranous glomerulonephritis,1262,"MN was treated with methylprednisolone as first-line therapy, then she was changed to rituximab for a relapse.",True,"Is the triple 'Methylprednisolone treats membranous glomerulonephritis' supported by the sentence: 'MN was treated with methylprednisolone as first-line therapy, then she was changed to rituximab for a relapse.'?","Yes, there is indirect support for the claim that methylprednisolone treats membranous glomerulonephritis (MN) based on the statement provided. The patient was initially treated with methylprednisolone as first-line therapy for MN, which suggests that methylprednisolone is an appropriate treatment option for MN. However, it is essential to recognize that this is indirect evidence because it does not explicitly demonstrate that methylprednisolone caused an improvement in MN symptoms; it only shows its use in treatment. Other factors may have influenced the decision to switch therapies, such as side effects, relapse triggers, or patient preference. Thus, while there is some support for the claim based on this statement alone, further investigation would be necessary for more definitive evidence." +14027935,Methylprednisolone treats diffuse large B-cell lymphoma,1263,"This study evaluated the influence of prior exposure to rituximab on response rates and survival in patients with diffuse large B-cell lymphoma treated with rituximab plus etoposide, cytarabine, cisplatinum and methylprednisolone (R-ESHAP).",False,"Is the triple 'Methylprednisolone treats diffuse large B-cell lymphoma' supported by the sentence: 'This study evaluated the influence of prior exposure to rituximab on response rates and survival in patients with diffuse large B-cell lymphoma treated with rituximab plus etoposide, cytarabine, cisplatinum and methylprednisolone (R-ESHAP).'?","No, the statement does not provide direct support for the claim that ""Methylprednisolone treats diffuse large B-cell lymphoma."" The study in question is investigating the impact of prior rituximab exposure on response rates in patients with diffuse large B-cell lymphoma who were treated with R-ESHAP, which includes methylprednisolone as part of its regimen. However, it does not imply that methylprednisolone is solely responsible for treating diffuse large B-cell lymphoma in isolation from other agents in the R-ESHAP protocol. + + + + To establish whether methylprednisolone could be an effective treatment for diffuse large B-cell lymphoma, one would need additional evidence from studies specifically designed to evaluate its therapeutic potential in treating this type of lymphoma. + + + + In summary, while methylprednisolone is used in treating diffuse large B-cell lymphoma as part of the R-ESHAP protocol in this study, it does not provide sufficient evidence that methylprednisolone alone can treat diffuse large" +13679356,Methylprednisolone treats hemophagocytic syndrome,1264,"A 46 year old woman who presented with severe multiorgans involvement including liver brain, cardio-pulmonary failure, gastrointestinal bleeding, progressive cytopenia, DIC and hemophagocytic syndrome during the convalescent phase of Dengue type II has been successfully treated primarily with pulse methyl prednisolone and high dose intravenous immunoglobulin G.",True,"Is the triple 'Methylprednisolone treats hemophagocytic syndrome' supported by the sentence: 'A 46 year old woman who presented with severe multiorgans involvement including liver brain, cardio-pulmonary failure, gastrointestinal bleeding, progressive cytopenia, DIC and hemophagocytic syndrome during the convalescent phase of Dengue type II has been successfully treated primarily with pulse methyl prednisolone and high dose intravenous immunoglobulin G.'?","Yes, the statement does provide indirect support for the claim that methylprednisolone treats hemophagocytic syndrome. The case report describes a patient suffering from hemophagocytic syndrome during the convalescent phase of Dengue type II who was successfully treated primarily with pulse methylprednisolone and high-dose intravenous immunoglobulin G. The fact that the patient responded positively to methylprednisolone treatment suggests that it may be an effective treatment option for hemophagocytic syndrome, although further studies would be required to establish a definitive causal relationship and determine whether methylprednisolone is superior to other treatment options for hemophagocytic syndrome. + + However, it is important to note that methylprednisolone is not being used in isolation in this case; it is being administered in combination with intravenous immunoglobulin G (IVIG). Therefore, it is possible that IVIG may be contributing to the patient's recovery as well. It is also possible that other factors unrelated to treatment may have influenced the patient's outcome. + + In summary, while there is some evidence" +13619118,Methylprednisolone treats chronic obstructive pulmonary disease,1265,"In conclusion, methylprednisolone in combination with conventional medical therapy not only improved lung function values but also mean nocturnal oxyhemoglobin saturation and sleep duration in clinically stabilized COPD patients who experience nocturnal oxyhemoglobin desaturation.",True,"Is the triple 'Methylprednisolone treats chronic obstructive pulmonary disease' supported by the sentence: 'In conclusion, methylprednisolone in combination with conventional medical therapy not only improved lung function values but also mean nocturnal oxyhemoglobin saturation and sleep duration in clinically stabilized COPD patients who experience nocturnal oxyhemoglobin desaturation.'?","Yes, the statement does provide indirect support for the claim that methylprednisolone treats chronic obstructive pulmonary disease (COPD). The study indicates that methylprednisolone, when used in combination with conventional medical therapy, improved lung function values and nocturnal oxyhemoglobin saturation in clinically stabilized COPD patients who experience nocturnal oxyhemoglobin desaturation. These improvements suggest that methylprednisolone has a positive impact on COPD symptoms and related complications, implying that it may be an effective treatment option for COPD patients. However, it is important to note that methylprednisolone is typically used for short-term management of exacerbations rather than long-term treatment due to potential side effects associated with prolonged steroid use. + + In summary, while the statement does not explicitly prove that methylprednisolone treats COPD on its own, it does provide evidence that methylprednisolone may be beneficial as an adjunct therapy for managing specific COPD symptoms in certain patient populations. Further research is needed to fully establish its therapeutic potential for COPD treatment." +13533673,Methylprednisolone treats macrophage activation syndrome,1266,"Following treatment with etanercept, ibuprofen, methylprednisolone, and phenylbutazone for 3 weeks, MAS deteriorated and fatal cerebral edema occurred within only 24 h.",False,"Is the triple 'Methylprednisolone treats macrophage activation syndrome' supported by the sentence: 'Following treatment with etanercept, ibuprofen, methylprednisolone, and phenylbutazone for 3 weeks, MAS deteriorated and fatal cerebral edema occurred within only 24 h.'?","No, the statement does not provide indirect support for the claim that ""Methylprednisolone treats macrophage activation syndrome (MAS)"". In fact, it seems to suggest the opposite: despite treatment including methylprednisolone among other medications, MAS deteriorated rapidly within 24 hours leading to fatal cerebral edema. This implies that methylprednisolone was either ineffective in treating MAS in this particular case or that additional factors contributed to the poor outcome. Nonetheless, it is important to note that a single case study does not establish definitive evidence for or against therapeutic efficacy; controlled clinical trials would be required for that purpose." +13161419,Methylprednisolone treats systemic sclerosis,1267,"CONCLUSION: The results of this pilot study suggest that the combination of MMF, IV MP and low-dose GC might achieve good clinical, functional and radiological results in patients suffering from severe early SSc.",True,"Is the triple 'Methylprednisolone treats systemic sclerosis' supported by the sentence: 'CONCLUSION: The results of this pilot study suggest that the combination of MMF, IV MP and low-dose GC might achieve good clinical, functional and radiological results in patients suffering from severe early SSc.'?","Yes, indirect support can be inferred from the statement provided. The conclusion states that a combination therapy including intravenous Methylprednisolone (IV MP) has shown promising results in treating severe early Systemic Sclerosis (SSc). However, it is important to note that the statement does not explicitly claim that Methylprednisolone alone treats SSc; rather it supports the efficacy of the combined treatment regimen that includes Methylprednisolone. + + + + The statement comes from a pilot study which typically has smaller sample sizes and less statistical power compared to larger-scale clinical trials; thus its conclusions should be interpreted with caution. Ideally, further research should be conducted to specifically evaluate the effectiveness of Methylprednisolone as a standalone treatment for systemic sclerosis in order to establish stronger support for such a claim." +13096165,Methylprednisolone treats optic nerve disorder,1268,"Dysthyroid optic neuropathy is best treated with intravenous pulsed methylprednisolone; if visual functions do not recover, urgent surgical decompression is indicated.",True,"Is the triple 'Methylprednisolone treats optic nerve disorder' supported by the sentence: 'Dysthyroid optic neuropathy is best treated with intravenous pulsed methylprednisolone; if visual functions do not recover, urgent surgical decompression is indicated.'?","Yes, the statement does provide indirect support for the phrase ""Methylprednisolone treats optic nerve disorder"". The statement suggests that dysthyroid optic neuropathy, which is an optic nerve disorder, is best treated with intravenous pulsed methylprednisolone. This implies that methylprednisolone is an effective treatment for at least one type of optic nerve disorder. However, it's important to note that this does not necessarily mean that methylprednisolone is effective for all types of optic nerve disorders. The effectiveness of methylprednisolone for other types of optic nerve disorders would need to be evaluated separately based on available evidence." +12975348,Methylprednisolone treats mature T-cell and NK-cell non-Hodgkin lymphoma,1269,"Gemcitabine, cisplatin and methylprednisolone for the treatment of patients with peripheral T-cell lymphoma: the Royal Marsden Hospital experience.",False,"Is the triple 'Methylprednisolone treats mature T-cell and NK-cell non-Hodgkin lymphoma' supported by the sentence: 'Gemcitabine, cisplatin and methylprednisolone for the treatment of patients with peripheral T-cell lymphoma: the Royal Marsden Hospital experience.'?","No, the statement does not provide direct support for the claim that ""Methylprednisolone treats mature T-cell and NK-cell non-Hodgkin lymphoma"". The article cited discusses a treatment regimen that includes methylprednisolone, gemcitabine, and cisplatin for peripheral T-cell lymphoma. However, it does not explicitly state that methylprednisolone is responsible for treating mature T-cell and NK-cell non-Hodgkin lymphoma specifically. + + + To further explain, in clinical settings, drugs like methylprednisolone often form part of combination therapies due to their immunosuppressive properties. While such drugs may contribute to positive patient outcomes in certain treatment regimens, attributing their impact solely on specific subtypes of non-Hodgkin lymphoma without further investigation would be an oversimplification of the complex interplay between various treatment components and individual patient characteristics within these heterogeneous diseases. + + + In conclusion, while methylprednisolone may be used in treating mature T-cell and NK-cell non-" +12450216,Methylprednisolone treats bronchopulmonary dysplasia,1270,Hypertrophic cardiomyopathy in preterm infants treated with methylprednisolone for bronchopulmonary dysplasia.,True,Is the triple 'Methylprednisolone treats bronchopulmonary dysplasia' supported by the sentence: 'Hypertrophic cardiomyopathy in preterm infants treated with methylprednisolone for bronchopulmonary dysplasia.'?,"Yes, the statement does provide indirect support for the claim that methylprednisolone treats bronchopulmonary dysplasia (BPD). The reason is that methylprednisolone is being used as a treatment for hypertrophic cardiomyopathy in preterm infants who have BPD. This implies that methylprednisolone is being administered in the context of BPD management, suggesting that it may have some therapeutic effect on BPD itself, even if that is not the primary condition being treated. + + + + However, it is important to note that this does not constitute direct evidence for the effectiveness of methylprednisolone in treating BPD. To establish that, we would need clinical trials or other rigorous studies specifically designed to evaluate the impact of methylprednisolone on BPD outcomes. The current statement indicates an association between methylprednisolone use and BPD management but does not prove causation." +11895116,Methylprednisolone treats plasma cell myeloma,1271,Multiple myeloma of Stage IIa was diagnosed and she was given cytostatic therapy with 17.5 mg melphalan and 112 mg methylprednisolone daily by mouth (for 4 days at intervals of 6 weeks).,True,Is the triple 'Methylprednisolone treats plasma cell myeloma' supported by the sentence: 'Multiple myeloma of Stage IIa was diagnosed and she was given cytostatic therapy with 17.5 mg melphalan and 112 mg methylprednisolone daily by mouth (for 4 days at intervals of 6 weeks).'?,"Yes, the statement does provide indirect support for the phrase ""Methylprednisolone treats plasma cell myeloma."" The patient in question was diagnosed with multiple myeloma (a type of plasma cell myeloma) and was administered methylprednisolone as part of her cytostatic therapy. This suggests that methylprednisolone is used in treating plasma cell myeloma, at least in combination with other drugs like melphalan. However, it is important to note that correlation does not imply causation, so while methylprednisolone is used in treating plasma cell myeloma, it does not necessarily mean it is solely responsible for treating it." +11882768,Methylprednisolone treats Cognitive impairment,1272,One-year cyclophosphamide treatment combined with methylprednisolone improves cognitive dysfunction in progressive forms of multiple sclerosis.,True,Is the triple 'Methylprednisolone treats Cognitive impairment' supported by the sentence: 'One-year cyclophosphamide treatment combined with methylprednisolone improves cognitive dysfunction in progressive forms of multiple sclerosis.'?,"Yes, there is indirect support for the statement that ""Methylprednisolone treats cognitive impairment"" in light of the provided evidence: ""One-year cyclophosphamide treatment combined with methylprednisolone improves cognitive dysfunction in progressive forms of multiple sclerosis."" + + + The rationale behind this conclusion lies in recognizing that methylprednisolone is an essential component in an intervention shown to improve cognitive dysfunction in multiple sclerosis patients. This suggests that methylprednisolone has some therapeutic effect in addressing cognitive impairment in that specific context. + + + However, it is essential to acknowledge that this evidence does not provide direct proof that methylprednisolone is solely responsible for treating cognitive impairment in multiple sclerosis patients. The intervention also includes cyclophosphamide treatment, which may contribute synergistically to cognitive improvement in these patients. + + + Therefore, while there is indirect support for methylprednisolone having some positive impact on cognitive impairment based on this statement, further investigation would be required for more definitive conclusions regarding its isolated efficacy in treating cognitive imp" +11547088,Methylprednisolone treats thrombotic thrombocytopenic purpura,1273,"The hematologic evaluations and her clinical course revealed the diagnosis of TTP, so plasma exchange and methyl-prednisolone therapy were initiated.",True,"Is the triple 'Methylprednisolone treats thrombotic thrombocytopenic purpura' supported by the sentence: 'The hematologic evaluations and her clinical course revealed the diagnosis of TTP, so plasma exchange and methyl-prednisolone therapy were initiated.'?","Yes, the statement does provide indirect support for the claim that methylprednisolone treats thrombotic thrombocytopenic purpura (TTP). The statement indicates that after diagnosing TTP in a patient through hematologic evaluations and clinical course assessment, plasma exchange and methylprednisolone therapy were initiated. This implies that methylprednisolone was used as part of the treatment regimen for TTP, thus offering support for its use in managing TTP even if not explicitly stating that it treats TTP. However, it should be noted that direct causality cannot be inferred from this statement alone; more rigorous clinical studies would be required for definitive evidence regarding its therapeutic effect on TTP." +11313619,Methylprednisolone treats vestibular neuronitis,1274,"METHODS: We performed a prospective, randomized, double-blind, two-by-two factorial trial in which patients with acute vestibular neuritis were randomly assigned to treatment with placebo, methylprednisolone, valacyclovir, or methylprednisolone plus valacyclovir.",True,"Is the triple 'Methylprednisolone treats vestibular neuronitis' supported by the sentence: 'METHODS: We performed a prospective, randomized, double-blind, two-by-two factorial trial in which patients with acute vestibular neuritis were randomly assigned to treatment with placebo, methylprednisolone, valacyclovir, or methylprednisolone plus valacyclovir.'?","Yes, the statement does provide indirect support for the claim that methylprednisolone treats vestibular neuronitis. The methodology described in the statement includes a clinical trial where patients diagnosed with acute vestibular neuritis were randomly assigned to receive treatment with methylprednisolone (either alone or in combination with valacyclovir). The fact that methylprednisolone was selected as a treatment group in a prospective, randomized, double-blind trial suggests that there is some basis for believing that it may have therapeutic benefits for treating vestibular neuronitis. + + However, it is important to note that while this methodology supports methylprednisolone as a potential treatment for vestibular neuronitis, it does not definitively prove that methylprednisolone treats vestibular neuronitis. The trial would need to be evaluated for factors such as sample size, statistical significance, effect size, potential confounding factors, and adherence to best practices in clinical trial design and analysis before drawing any definitive conclusions about its efficacy as a treatment for vestibular neuronitis." +10801960,Methylprednisolone treats B-cell chronic lymphocytic leukemia,1275,High dose methylprednisolone can induce remissions in CLL patients with p53 abnormalities.,False,Is the triple 'Methylprednisolone treats B-cell chronic lymphocytic leukemia' supported by the sentence: 'High dose methylprednisolone can induce remissions in CLL patients with p53 abnormalities.'?,"No, the statement ""High dose methylprednisolone can induce remissions in CLL patients with p53 abnormalities"" does not provide direct support for the claim that ""Methylprednisolone treats B-cell chronic lymphocytic leukemia"" (CLL). The original statement refers specifically to CLL patients with p53 abnormalities, which is not equivalent to making a general claim about treating all B-cell chronic lymphocytic leukemia cases. + + However, it is important to note that indirect support might be inferred if there is evidence suggesting that p53 abnormalities play a significant role in CLL progression, making it reasonable that methylprednisolone could potentially be used as a treatment for CLL in general. Nevertheless, without further information linking p53 abnormalities and CLL progression as well as methylprednisolone's effect on CLL without p53 abnormalities, it is not possible to establish direct support for the original claim based on the provided statement alone. + + In conclusion, while it is plausible that methylprednisolone might be useful" +10634179,Methylprednisolone treats Crohn disease,1276,An example of acute pancreatitis developing five weeks after initial treatment with 5-aminosalicylic acid (5-ASA) and methylprednisolone for severe Crohn's disease is reported in a 37 year old female patient.,False,Is the triple 'Methylprednisolone treats Crohn disease' supported by the sentence: 'An example of acute pancreatitis developing five weeks after initial treatment with 5-aminosalicylic acid (5-ASA) and methylprednisolone for severe Crohn's disease is reported in a 37 year old female patient.'?,"No, the statement does not provide direct or indirect support for the claim that ""Methylprednisolone treats Crohn disease"". The statement reports an adverse event (acute pancreatitis) in a patient being treated for Crohn's disease with methylprednisolone and 5-ASA. It does not provide any information about the therapeutic effect of methylprednisolone on Crohn disease. In fact, it could be argued that it suggests a potential side effect or complication associated with methylprednisolone use in Crohn disease patients. Therefore, it does not support the claim that methylprednisolone is an effective treatment for Crohn disease." +10341065,Methylprednisolone treats severe acute respiratory syndrome,1277,Twenty-nine of the 30 SARS patients were treated by methylprednisolone.,True,Is the triple 'Methylprednisolone treats severe acute respiratory syndrome' supported by the sentence: 'Twenty-nine of the 30 SARS patients were treated by methylprednisolone.'?,"Yes, the statement does provide indirect support for the claim that methylprednisolone treats severe acute respiratory syndrome (SARS). The fact that 29 out of 30 SARS patients were treated with methylprednisolone suggests that there is a potential association between methylprednisolone use and improved outcomes in SARS patients. However, it is important to note that correlation does not imply causation. The statement does not provide direct evidence that methylprednisolone is an effective treatment for SARS; it merely indicates an observed association that warrants further investigation. + + + + To establish causation and draw definitive conclusions about methylprednisolone as an effective treatment for SARS, additional information would be required: + + + + 1. A control group that did not receive methylprednisolone treatment for comparison purposes + 2. Information on other treatments administered concurrently + 3. Quantitative measures of treatment efficacy (e.g., symptom improvement rates, mortality rates) + 4. Statistical analysis assessing the significance of observed associations + 5. Replication studies" +10289517,Methylprednisolone treats graft versus host disease,1278,"CASE SUMMARY: A 2-year-old white boy with a history of relapsed acute lymphoblastic leukemia underwent a bone marrow transplant and developed graft-versus-host disease, which was treated with methylprednisolone.",True,"Is the triple 'Methylprednisolone treats graft versus host disease' supported by the sentence: 'CASE SUMMARY: A 2-year-old white boy with a history of relapsed acute lymphoblastic leukemia underwent a bone marrow transplant and developed graft-versus-host disease, which was treated with methylprednisolone.'?","Yes, the statement does provide indirect support for the claim that methylprednisolone treats graft versus host disease (GvHD). The case summary states that a patient diagnosed with graft versus host disease was treated with methylprednisolone, implying that the drug was used as part of the therapeutic strategy for managing GvHD. + + However, it is important to note that correlation does not imply causation, and while methylprednisolone was used in treating GvHD in this case, it does not necessarily mean that methylprednisolone is solely responsible for treating GvHD in all cases. Further investigation into clinical trials, peer-reviewed studies, and meta-analyses would be required to establish more robust evidence supporting methylprednisolone as an effective treatment for GvHD. + + Additionally, it should be considered that treatment decisions in clinical settings can be influenced by various factors such as comorbidities, potential side effects, patient preferences, and concomitant medications. Therefore, while this case summary supports methylprednisolone as an option for treating GvHD, it is crucial to consider other evidence in order to make well-" +10221573,Methylprednisolone treats myeloproliferative neoplasm,1279,The effects of HDMP should be explored in patients with other subtypes of AML who present with MT.,False,Is the triple 'Methylprednisolone treats myeloproliferative neoplasm' supported by the sentence: 'The effects of HDMP should be explored in patients with other subtypes of AML who present with MT.'?,"No, the phrase ""Methylprednisolone treats myeloproliferative neoplasm"" does not receive indirect support from the statement: ""The effects of HDMP should be explored in patients with other subtypes of AML who present with MT."" + + The statement in question refers to High-Dose Methylprednisolone (HDMP) and its potential effects on certain subtypes of Acute Myeloid Leukemia (AML) that present with Measurable Residual Disease (MRD). This statement does not make any direct or indirect reference to Methylprednisolone being an effective treatment for Myeloproliferative Neoplasms (MPNs). + + Myeloproliferative Neoplasms (MPNs) and Acute Myeloid Leukemia (AML) are two distinct types of hematological malignancies with different pathophysiological features, risk factors, clinical presentations, and treatment approaches. Therefore, evidence supporting treatment options for one condition cannot be indirectly inferred for another condition based solely on shared terminology (myeloid in this case) without explicit mention in the statement itself." +10136260,Methylprednisolone treats acute lymphoblastic leukemia,1280,"We examined the effect of high-dose methylprednisolone (HDMP) on blast reduction rate and compared it to conventional dose steroid treatment, administered during the first 7+ days of the induction remission period in patients with acute lymphoblastic leukemia (ALL).",True,"Is the triple 'Methylprednisolone treats acute lymphoblastic leukemia' supported by the sentence: 'We examined the effect of high-dose methylprednisolone (HDMP) on blast reduction rate and compared it to conventional dose steroid treatment, administered during the first 7+ days of the induction remission period in patients with acute lymphoblastic leukemia (ALL).'?","Yes, indirect support can be inferred from the statement provided. The study examined the effect of high-dose methylprednisolone (HDMP) on blast reduction rate in patients with acute lymphoblastic leukemia (ALL). The fact that they compared it to conventional dose steroid treatment implies that methylprednisolone is being considered as a potential treatment for ALL, which is a form of leukemia. + + However, it is important to note that while this statement suggests methylprednisolone may have some positive effect on ALL treatment, it does not explicitly state that methylprednisolone ""treats"" ALL. The term ""treats"" implies that it is an established therapy for ALL, which cannot be concluded from this statement alone. + + Furthermore, the study only looked at blast reduction rate, which is one aspect of leukemia treatment. Other factors such as overall survival rate, side effects, and long-term impacts would also need to be considered when evaluating whether methylprednisolone is an effective treatment for ALL. Therefore, while there is some indirect support for methylprednisolone being used in ALL treatment" +10049014,"Methylprednisolone treats dermatitis, atopic",1281,"The objective of this multicentre, parallel, blinded, randomized controlled study was to evaluate the efficacy and the safety of cyclosporine (CsA group, 117 dogs) in comparison with methylprednisolone (MP group, 59 dogs) in the treatment of atopic dermatitis for 4 months.",True,"Is the triple 'Methylprednisolone treats dermatitis, atopic' supported by the sentence: 'The objective of this multicentre, parallel, blinded, randomized controlled study was to evaluate the efficacy and the safety of cyclosporine (CsA group, 117 dogs) in comparison with methylprednisolone (MP group, 59 dogs) in the treatment of atopic dermatitis for 4 months.'?","Yes, the statement does provide indirect support for the claim that ""Methylprednisolone treats dermatitis, atopic"". The study mentioned is designed to compare the efficacy and safety of cyclosporine (CsA) and methylprednisolone (MP) in treating atopic dermatitis in dogs over four months. By participating in such a study, it suggests that methylprednisolone has been considered as a potential treatment option for atopic dermatitis by researchers in this field. + + However, it is important to note that indirect support does not equate to definitive proof. The study does not explicitly state that methylprednisolone treats atopic dermatitis; rather it investigates its efficacy in comparison to another treatment option. Further evidence from additional studies would be required for stronger support for the claim that methylprednisolone treats atopic dermatitis in dogs." +9980473,Methylprednisolone treats immunoglobulin a vasculitis,1282,"CASE DESCRIPTION: A 33-year-old woman previously treated with methylprednisolone and cyclophosphamide for Henoch-Schonlein purpura was transferred from a referring hospital because of sore throat, fever, and chills.",False,"Is the triple 'Methylprednisolone treats immunoglobulin a vasculitis' supported by the sentence: 'CASE DESCRIPTION: A 33-year-old woman previously treated with methylprednisolone and cyclophosphamide for Henoch-Schonlein purpura was transferred from a referring hospital because of sore throat, fever, and chills.'?","No, the statement does not provide direct support for the claim that ""Methylprednisolone treats immunoglobulin A vasculitis (IgAV)"". The case description refers to a patient with Henoch-Schonlein purpura (HSP), which is closely related but distinct from IgAV. The patient was treated previously with methylprednisolone and cyclophosphamide, but no information is provided about her response to treatment or whether her condition was indeed IgAV. Therefore, it is impossible to determine whether methylprednisolone is effective in treating IgAV based on this statement alone. However, methylprednisolone is commonly used in treating various vasculitides including IgAV due to its anti-inflammatory properties." +9720542,Methylprednisolone treats lupus nephritis,1283,The last significant breakthrough in the treatment of systemic lupus erythematosus (SLE) was the use of cyclophosphamide and methylprednisolone in the treatment of lupus nephritis.,True,Is the triple 'Methylprednisolone treats lupus nephritis' supported by the sentence: 'The last significant breakthrough in the treatment of systemic lupus erythematosus (SLE) was the use of cyclophosphamide and methylprednisolone in the treatment of lupus nephritis.'?,"Yes, the statement does provide indirect support for the claim that methylprednisolone treats lupus nephritis. The key word here is 'indirect'. The statement suggests that cyclophosphamide and methylprednisolone were used together in treating lupus nephritis, which implies that methylprednisolone has some therapeutic effect on lupus nephritis. However, it does not directly prove that methylprednisolone alone is effective in treating lupus nephritis. It is important to note that clinical trials and further research would be necessary to establish a direct causal relationship between methylprednisolone and improvement in lupus nephritis symptoms." +8761529,Methylprednisolone treats asthma,1284,Methylprednisolone suleptanate (Promedrol) is a prodrug of methylprednisolone being developed by Pharmacia Corp (formerly Pharmacia & Upjohn) for the treatment of asthma.,True,Is the triple 'Methylprednisolone treats asthma' supported by the sentence: 'Methylprednisolone suleptanate (Promedrol) is a prodrug of methylprednisolone being developed by Pharmacia Corp (formerly Pharmacia & Upjohn) for the treatment of asthma.'?,"Yes, there is indirect support for the claim that Methylprednisolone treats asthma based on the provided statement. + + + Methylprednisolone suleptanate (Promedrol) is indeed a prodrug of methylprednisolone being developed by Pharmacia Corp (formerly Pharmacia & Upjohn) for the treatment of asthma. A prodrug is an inactive form of a drug that is metabolically converted into its active form in the body after administration (Stella, 1985). In this case, Methylprednisolone suleptanate (Promedrol) is metabolized into Methylprednisolone after being administered. + + + Methylprednisolone is a type of corticosteroid that is commonly used in treating asthma due to its anti-inflammatory properties (National Asthma Education Prevention Program, 2007). Corticosteroids reduce inflammation in airways by suppressing immune cells that release chemicals causing inflammation (Barnes, 2013)." +8588816,Methylprednisolone treats Bell's palsy,1285,"On these basis, we have studied the efficacity of parenteral association of 30 mg/Kg/j of Aciclovir and 1 mg/Kg/j of Methylprednisolone in the treatment of Bell's palsy with less than 12 days of evolution.",True,"Is the triple 'Methylprednisolone treats Bell's palsy' supported by the sentence: 'On these basis, we have studied the efficacity of parenteral association of 30 mg/Kg/j of Aciclovir and 1 mg/Kg/j of Methylprednisolone in the treatment of Bell's palsy with less than 12 days of evolution.'?","Yes, indirectly it does support that Methylprednisolone can be used in treating Bell's palsy. The statement mentions a study where patients with Bell's palsy of less than 12 days evolution were treated with Aciclovir and Methylprednisolone in combination. This implies that Methylprednisolone is considered as a potential treatment for Bell's palsy in medical literature. + + + However, it is important to note that this statement does not provide direct evidence that Methylprednisolone alone treats Bell's palsy effectively. It only suggests that it has been used in conjunction with Aciclovir in treating Bell's palsy within 12 days of onset. Further research would be needed to establish whether Methylprednisolone is an effective monotherapy for Bell's palsy. + + + Also, it should be noted that while Methylprednisolone is often used in treating Bell's palsy due to its anti-inflammatory effects, its usage should be under medical supervision due to potential side effects such as increased blood sugar" +8568939,Methylprednisolone treats myasthenia gravis,1286,"Treatment with methylprednisolone for myasthenia gravis was associated with a marked decrease in both biochemical markers of bone formation and resorption without any changes in endogenous cAMP and serum levels of calcium, PTH, and 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3].",False,"Is the triple 'Methylprednisolone treats myasthenia gravis' supported by the sentence: 'Treatment with methylprednisolone for myasthenia gravis was associated with a marked decrease in both biochemical markers of bone formation and resorption without any changes in endogenous cAMP and serum levels of calcium, PTH, and 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3].'?","No, the statement does not provide direct or indirect support for the claim that methylprednisolone treats myasthenia gravis. The statement focuses on the impact of methylprednisolone treatment on bone formation and resorption markers as well as calcium metabolism in patients with myasthenia gravis [1]. It does not provide any information about the efficacy of methylprednisolone in treating myasthenia gravis symptoms or improving patients' clinical status. + + Myasthenia gravis is an autoimmune neuromuscular disorder characterized by muscle weakness [2]. Treatment options include cholinesterase inhibitors, corticosteroids (such as methylprednisolone), immunosuppressive drugs, plasma exchange, and intravenous immunoglobulin [3]. Therefore, further evidence is required to establish whether methylprednisolone indeed effectively treats myasthenia gravis. + + References: + 1. Verschueren P, et al. Glucocorticoid-induced bone loss in myasthenia gravis: effect of methylprednisolone pulse therapy on" +8562694,Methylprednisolone treats endocrine exophthalmos,1287,PATIENTS AND METHODS: Fourteen euthyroid patients with severe Graves' ophthalmopathy were treated with high-dose intravenous methylprednisolone during 6 months and followed-up for 24-48 months by clinical and ophthalmological assessment.,True,Is the triple 'Methylprednisolone treats endocrine exophthalmos' supported by the sentence: 'PATIENTS AND METHODS: Fourteen euthyroid patients with severe Graves' ophthalmopathy were treated with high-dose intravenous methylprednisolone during 6 months and followed-up for 24-48 months by clinical and ophthalmological assessment.'?,"Yes, the statement does provide indirect support for the claim that methylprednisolone treats endocrine exophthalmos (a symptom of Graves' ophthalmopathy). The patients in question had severe Graves' ophthalmopathy and were treated with high-dose intravenous methylprednisolone for six months. The follow-up period also suggests that there was an interest in tracking the long-term effects of this treatment. + + However, it is important to note that while this study design suggests that methylprednisolone may have therapeutic benefits for Graves' ophthalmopathy, it does not definitively prove that it treats endocrine exophthalmos specifically. The study does not detail the specific symptoms each patient experienced before and after treatment, nor does it explicitly state that endocrine exophthalmos was alleviated by methylprednisolone treatment. Further studies would be needed to explicitly test this claim." +8503951,Methylprednisolone treats ulcerative colitis,1288,The current study evaluated the efficacy and safety of unfractionated heparin in the treatment of ulcerative colitis in comparison with methylprednisolone.,True,Is the triple 'Methylprednisolone treats ulcerative colitis' supported by the sentence: 'The current study evaluated the efficacy and safety of unfractionated heparin in the treatment of ulcerative colitis in comparison with methylprednisolone.'?,"Yes, based on the statement provided, there is indirect support for the claim that methylprednisolone treats ulcerative colitis. The study in question compared unfractionated heparin and methylprednisolone in treating ulcerative colitis. The fact that methylprednisolone was included in such a study implies that it is considered a potential treatment option for ulcerative colitis. However, it is important to note that indirect support does not equate to definitive proof; further investigation would be necessary to establish the efficacy and safety of methylprednisolone specifically for ulcerative colitis treatment." +8464737,Methylprednisolone treats kidney disorder,1289,"Post partum acute renal failure and type IV lupus nephropathy were treated with hemodialysis, methylprednisolone, cyclophosphamide and prednisone.",True,"Is the triple 'Methylprednisolone treats kidney disorder' supported by the sentence: 'Post partum acute renal failure and type IV lupus nephropathy were treated with hemodialysis, methylprednisolone, cyclophosphamide and prednisone.'?","Yes, the statement does provide indirect support for the phrase ""Methylprednisolone treats kidney disorder"". The statement indicates that methylprednisolone was used in the treatment of post partum acute renal failure and type IV lupus nephropathy. This suggests that methylprednisolone is considered effective in treating certain kidney disorders, even though it was used in conjunction with other treatments in this case. However, it is important to note that this does not constitute direct evidence that methylprednisolone alone treats kidney disorders, as it was used in combination with other treatments in this instance." +8427466,Methylprednisolone treats sinusitis,1290,"To resolve the controversy over whether corticosteroids promote or inhibit the resolution of sinusitis, we present a prospective study of 80 rabbits with surgically introduced pseudomonal sinusitis that were then treated in one of four arms: control, ceftazidime, methylprednisolone, and ceftazidime with methylprednisolone.",False,"Is the triple 'Methylprednisolone treats sinusitis' supported by the sentence: 'To resolve the controversy over whether corticosteroids promote or inhibit the resolution of sinusitis, we present a prospective study of 80 rabbits with surgically introduced pseudomonal sinusitis that were then treated in one of four arms: control, ceftazidime, methylprednisolone, and ceftazidime with methylprednisolone.'?","No, the statement does not provide direct support for the claim that methylprednisolone treats sinusitis. The study described in the statement investigates the effect of corticosteroids (including methylprednisolone) on pseudomonal sinusitis in rabbits, but it does not explicitly assess whether methylprednisolone is an effective treatment for sinusitis. The study is also conducted in rabbits, which may not translate directly to humans. Therefore, further investigation is needed before concluding that methylprednisolone treats sinusitis in humans." +8330903,Methylprednisolone treats systemic lupus erythematosus,1291,MAIN RESULTS: We found no randomised controlled trials comparing cyclophosphamide versus methylprednisolone for the treatment of neuropsychiatric involvement in the systemic lupus erythematosus.,False,Is the triple 'Methylprednisolone treats systemic lupus erythematosus' supported by the sentence: 'MAIN RESULTS: We found no randomised controlled trials comparing cyclophosphamide versus methylprednisolone for the treatment of neuropsychiatric involvement in the systemic lupus erythematosus.'?,"No, the statement does not provide indirect support for the claim that ""Methylprednisolone treats systemic lupus erythematosus."" The provided statement is from a systematic review examining randomized controlled trials comparing cyclophosphamide versus methylprednisolone for treating neuropsychiatric involvement in systemic lupus erythematosus (SLE). The absence of such trials does not imply that methylprednisolone is an effective treatment for SLE in general or that it treats neuropsychiatric involvement specifically. + + To provide indirect support for methylprednisolone as an effective treatment for SLE, there should be evidence showing its positive effects compared to other treatments (such as cyclophosphamide) in treating SLE or its symptoms in general. The statement only indicates that there is no evidence specifically comparing these two treatments in relation to neuropsychiatric involvement in SLE." +8291810,Methylprednisolone treats pneumonia,1292,High-dose methylprednisolone was administered for treatment of the pneumonitis.,True,Is the triple 'Methylprednisolone treats pneumonia' supported by the sentence: 'High-dose methylprednisolone was administered for treatment of the pneumonitis.'?,"Yes, indirectly it does support that statement because methylprednisolone is a type of corticosteroid often used in treating inflammation associated with various conditions including pneumonitis (inflammation of lung tissue often due to infection or injury). However, while this suggests methylprednisolone may be beneficial in treating symptoms caused by pneumonia-related pneumonitis, it does not explicitly confirm that methylprednisolone treats pneumonia itself. The original claim is more general than what is supported by the provided statement." +8227578,Methylprednisolone treats mucocutaneous lymph node syndrome,1293,"Additional antiinflammatory therapy, such as IV methylprednisolone and IV cyclophosphamide, may be helpful in treating persistent KD.",True,"Is the triple 'Methylprednisolone treats mucocutaneous lymph node syndrome' supported by the sentence: 'Additional antiinflammatory therapy, such as IV methylprednisolone and IV cyclophosphamide, may be helpful in treating persistent KD.'?","Yes, the statement does provide indirect support for the phrase ""Methylprednisolone treats mucocutaneous lymph node syndrome"" (Kawasaki Disease or KD). The statement suggests that methylprednisolone can be helpful in treating persistent KD, which is a form of mucocutaneous lymph node syndrome. Although it does not explicitly confirm that methylprednisolone treats KD, it implies that methylprednisolone has therapeutic benefits for KD patients, thus offering indirect support for the claim that methylprednisolone is an effective treatment for mucocutaneous lymph node syndrome. + + However, it is important to note that further investigation is necessary for more definitive conclusions as multiple factors can influence treatment outcomes for complex medical conditions like KD. These factors include patient characteristics (e.g., age, severity of symptoms), comorbidities (e.g., allergies, concurrent infections), dosage regimens, potential side effects, as well as alternative treatment options (e.g., aspirin, intravenous immunoglobulin). Additionally, randomized controlled trials (" +8095661,Methylprednisolone treats carpal tunnel syndrome,1294,Injection with methylprednisolone for carpal tunnel syndrome.,True,Is the triple 'Methylprednisolone treats carpal tunnel syndrome' supported by the sentence: 'Injection with methylprednisolone for carpal tunnel syndrome.'?,"Yes, the statement ""Injection with methylprednisolone for carpal tunnel syndrome"" does provide indirect support for the claim that ""Methylprednisolone treats carpal tunnel syndrome."" The use of methylprednisolone injections for carpal tunnel syndrome implies that methylprednisolone plays an active role in treating the condition by reducing inflammation in the carpal tunnel area. This evidence does not explicitly prove that methylprednisolone treats carpal tunnel syndrome but offers support for its therapeutic potential in managing the condition. However, it is essential to consider additional evidence from clinical trials and systematic reviews that assess the overall effectiveness of methylprednisolone in treating carpal tunnel syndrome for a more robust evaluation of the claim." +8083160,Methylprednisolone treats thrombocytopenia,1295,"After a course of high-dose methylprednisolone therapy with a diagnosis of Evans syndrome, complete response for thrombocytopenia and partial response for anemia was achieved.",True,"Is the triple 'Methylprednisolone treats thrombocytopenia' supported by the sentence: 'After a course of high-dose methylprednisolone therapy with a diagnosis of Evans syndrome, complete response for thrombocytopenia and partial response for anemia was achieved.'?","Yes, the statement does provide indirect support for the phrase ""Methylprednisolone treats thrombocytopenia"". The reason is that thrombocytopenia is mentioned as having achieved complete response after a course of high-dose methylprednisolone therapy in a patient diagnosed with Evans syndrome, which suggests that methylprednisolone had a positive impact on treating thrombocytopenia in this particular case. However, it is important to note that this is an observational finding in one case, so further studies would be needed to establish a definitive causal relationship between methylprednisolone treatment and thrombocytopenia improvement in a broader population." +8063034,Methylprednisolone treats granulomatosis with polyangiitis,1296,We describe a 44-year-old man with Wegener's granulomatosis who was treated with cyclophosphamide and methylprednisolone and who subsequently developed bilateral CMVR.,True,Is the triple 'Methylprednisolone treats granulomatosis with polyangiitis' supported by the sentence: 'We describe a 44-year-old man with Wegener's granulomatosis who was treated with cyclophosphamide and methylprednisolone and who subsequently developed bilateral CMVR.'?,"Yes, indirect support can be inferred from the statement provided for the phrase ""Methylprednisolone treats granulomatosis with polyangiitis"". The patient in question was diagnosed with Wegener's granulomatosis (a type of granulomatosis with polyangiitis) and was treated using methylprednisolone in combination with cyclophosphamide. The fact that they received methylprednisolone as part of their treatment regimen suggests that it was considered an appropriate therapeutic option for granulomatosis with polyangiitis by the treating medical professionals. + + + However, it is important to note that correlation does not imply causation; therefore, we cannot definitively conclude that methylprednisolone was solely responsible for treating granulomatosis with polyangiitis in this case based solely on this statement. Further evidence from clinical trials and studies is required to establish a direct causal relationship between methylprednisolone treatment and successful management of granulomatosis with polyangiitis." +8018847,Methylprednisolone treats Pain,1297,A comparative trial of botulinum toxin type A and methylprednisolone for the treatment of myofascial pain syndrome and pain from chronic muscle spasm.,True,Is the triple 'Methylprednisolone treats Pain' supported by the sentence: 'A comparative trial of botulinum toxin type A and methylprednisolone for the treatment of myofascial pain syndrome and pain from chronic muscle spasm.'?,"Yes, indirectly it does support that Methylprednisolone treats pain. The statement ""A comparative trial of botulinum toxin type A and methylprednisolone for the treatment of myofascial pain syndrome and pain from chronic muscle spasm"" implies that Methylprednisolone is used in a trial for treating pain (myofascial pain syndrome and pain from chronic muscle spasm). Therefore, it indirectly supports the claim that Methylprednisolone treats pain. However, it is important to note that this is an indirect inference based on the context provided in the statement and does not constitute definitive proof that Methylprednisolone is an effective treatment for all types of pain." +7905007,Methylprednisolone treats chronic progressive multiple sclerosis,1298,OBJECTIVE: To determine if there are variables linked to responsiveness to pulse cyclophosphamide/methylprednisolone therapy in progressive Multiple Sclerosis (MS).,False,Is the triple 'Methylprednisolone treats chronic progressive multiple sclerosis' supported by the sentence: 'OBJECTIVE: To determine if there are variables linked to responsiveness to pulse cyclophosphamide/methylprednisolone therapy in progressive Multiple Sclerosis (MS).'?,"No, the statement does not provide direct or indirect support for the claim that methylprednisolone treats chronic progressive multiple sclerosis (CPMS). The objective in the statement is focused on determining variables linked to responsiveness to pulse cyclophosphamide/methylprednisolone therapy in progressive MS, which is different from claiming that methylprednisolone treats CPMS. The statement is about understanding who might respond better to treatment involving methylprednisolone rather than making an assertion about its therapeutic effect on CPMS." +7853881,Methylprednisolone treats rheumatoid arthritis,1299,Oral low-dose glucocorticosteroids as compared with intravenous methylprednisolone pulses in the treatment of rheumatoid arthritis.,False,Is the triple 'Methylprednisolone treats rheumatoid arthritis' supported by the sentence: 'Oral low-dose glucocorticosteroids as compared with intravenous methylprednisolone pulses in the treatment of rheumatoid arthritis.'?,"No, the statement does not provide direct or indirect support for the phrase ""Methylprednisolone treats rheumatoid arthritis."" The study referenced in the statement is comparing oral low-dose glucocorticosteroids (a class of drugs that includes methylprednisolone) with intravenous methylprednisolone pulses in treating rheumatoid arthritis. The statement does not provide information about methylprednisolone specifically treating rheumatoid arthritis; instead, it focuses on comparing different administration methods for glucocorticosteroids in treating rheumatoid arthritis." +7827490,Methylprednisolone treats optic neuritis,1300,CONCLUSIONS: The ONTT has led to a dramatic reduction in the use of oral prednisone without a preceding course of intravenous methylprednisolone in the treatment of acute optic neuritis.,True,Is the triple 'Methylprednisolone treats optic neuritis' supported by the sentence: 'CONCLUSIONS: The ONTT has led to a dramatic reduction in the use of oral prednisone without a preceding course of intravenous methylprednisolone in the treatment of acute optic neuritis.'?,"Yes, the statement does provide indirect support for the claim that methylprednisolone treats optic neuritis. The ONTT (Optic Neuritis Treatment Trial) concluded that there was a significant reduction in oral prednisone use without first administering intravenous methylprednisolone for acute optic neuritis treatment. This suggests that intravenous methylprednisolone is an effective treatment for optic neuritis, as its use led to a reduction in oral prednisone treatment, which might imply that methylprednisolone is more efficacious in treating optic neuritis than oral prednisone alone. However, it is important to note that the statement does not offer direct evidence that methylprednisolone treats optic neuritis; it only implies its efficacy by contrasting it with another treatment method. Further investigation into clinical trials and experimental studies is necessary to establish a definitive conclusion on methylprednisolone as an effective treatment for optic neuritis." +7808987,Methylprednisolone treats autoimmune thrombocytopenic purpura,1301,CONCLUSION: A short intravenous course of high-dose methylprednisolone is effective as initial treatment of adults with ITP.,True,Is the triple 'Methylprednisolone treats autoimmune thrombocytopenic purpura' supported by the sentence: 'CONCLUSION: A short intravenous course of high-dose methylprednisolone is effective as initial treatment of adults with ITP.'?,"Yes, the statement does provide indirect support for the phrase ""Methylprednisolone treats autoimmune thrombocytopenic purpura (ITP)"". The conclusion in the statement suggests that high-dose methylprednisolone is effective as an initial treatment for adults with ITP, which is a form of autoimmune thrombocytopenic purpura. This implies that methylprednisolone has therapeutic benefits for ITP patients, thus supporting the idea that methylprednisolone treats autoimmune thrombocytopenic purpura. However, it is important to note that direct clinical application should be made under professional medical supervision considering individual patient circumstances and potential side effects." +7700869,Methylprednisolone treats Edema,1302,"Lipid peroxidation and oedema in experimental brain injury: comparison of treatment with methylprednisolone, tirilazad mesylate and vitamin E.",True,"Is the triple 'Methylprednisolone treats Edema' supported by the sentence: 'Lipid peroxidation and oedema in experimental brain injury: comparison of treatment with methylprednisolone, tirilazad mesylate and vitamin E.'?","Yes, there is indirect support for the claim that methylprednisolone treats edema based on the statement: ""Lipid peroxidation and oedema in experimental brain injury: comparison of treatment with methylprednisolone, tirilazad mesylate and vitamin E."" + + + The title itself mentions methylprednisolone as one of the treatments being compared in an experimental brain injury model. The term ""oedema"" is also present in the title, which is another way of referring to edema. Since methylprednisolone is being studied in relation to edema within the context of brain injury, it suggests that there is some basis for exploring its potential therapeutic benefits for treating edema. + + + However, it is essential to note that indirect support does not equate to definitive proof that methylprednisolone treats edema. Further investigation is required to establish causality, dosage information, potential side effects, and overall efficacy in treating edema under various conditions. Additionally, it is crucial to consider that correlation does not imply causation; thus, while methylprednisolone may have an impact on ed" +7668594,Methylprednisolone treats multiple sclerosis,1303,The same determinations were repeated on plasma and on CSF samples that were collected after the MS patients had ended a six-day treatment with high-dose methylprednisolone (MP).,False,Is the triple 'Methylprednisolone treats multiple sclerosis' supported by the sentence: 'The same determinations were repeated on plasma and on CSF samples that were collected after the MS patients had ended a six-day treatment with high-dose methylprednisolone (MP).'?,"No, the statement does not provide direct or indirect support for the claim that ""Methylprednisolone treats multiple sclerosis."" The statement only mentions that MS patients had undergone treatment with high-dose methylprednisolone for six days and that plasma and cerebrospinal fluid (CSF) samples were collected after treatment. It does not provide any information about the outcomes or effects of the treatment on multiple sclerosis symptoms or progression. Therefore, it is not possible to infer any relationship between methylprednisolone and multiple sclerosis treatment based on this statement alone." +7649490,Methylprednisolone treats aplastic anemia,1304,"Neutropenic infections are the major cause of morbidity and mortality in the treatment of aplastic anemia (AA) with antilymphocyte globulin (ALG), cyclosporin A (CSA), and methylprednisolone (MP).",True,"Is the triple 'Methylprednisolone treats aplastic anemia' supported by the sentence: 'Neutropenic infections are the major cause of morbidity and mortality in the treatment of aplastic anemia (AA) with antilymphocyte globulin (ALG), cyclosporin A (CSA), and methylprednisolone (MP).'?","Yes, the statement does provide indirect support for the claim that methylprednisolone treats aplastic anemia. The key phrase here is ""and methylprednisolone (MP)"", which implies that methylprednisolone is part of the treatment regimen for aplastic anemia (AA). However, it does not explicitly state that methylprednisolone treats AA; rather it suggests that it is used in conjunction with other treatments (ALG and CSA) to manage complications (neutropenic infections) associated with AA treatment. Therefore, while there is some support for the claim, it is not a direct confirmation that methylprednisolone is an independent treatment for AA. + + It is important to note that medical treatments are often complex and involve multiple components, each addressing different aspects of a disease or its symptoms. Therefore, finding a drug mentioned in the context of treating a condition does not necessarily mean it is an independent treatment for that condition. It could also be part of a larger treatment regimen or used to manage complications arising from treatment." +7552935,Methylprednisolone treats Inflammation,1305,Methylprednisolone treatment resulted in the greatest reduction in the inflammatory cell infiltrate but the numbers of infected neurons did not increase concomitantly.,True,Is the triple 'Methylprednisolone treats Inflammation' supported by the sentence: 'Methylprednisolone treatment resulted in the greatest reduction in the inflammatory cell infiltrate but the numbers of infected neurons did not increase concomitantly.'?,"Yes, the statement does provide indirect support for the phrase ""Methylprednisolone treats Inflammation"". The statement suggests that methylprednisolone treatment led to a reduction in inflammatory cell infiltrate, which is an indicator of reduced inflammation. This implies that methylprednisolone has an anti-inflammatory effect, thus supporting the claim that it treats inflammation. However, it's important to note that this is an indirect inference based on one specific experimental outcome. The overall efficacy of methylprednisolone in treating inflammation would need to be evaluated across multiple studies and contexts." +7483648,Methylprednisolone treats adult acute respiratory distress syndrome,1306,Severe systemic inflammatory response syndrome with shock and ARDS resulting from Still's disease: clinical response with high-dose pulse methylprednisolone therapy.,True,Is the triple 'Methylprednisolone treats adult acute respiratory distress syndrome' supported by the sentence: 'Severe systemic inflammatory response syndrome with shock and ARDS resulting from Still's disease: clinical response with high-dose pulse methylprednisolone therapy.'?,"Yes, the statement does provide indirect support for the claim that methylprednisolone treats adult acute respiratory distress syndrome (ARDS). The statement suggests that high-dose pulse methylprednisolone therapy was effective in treating a patient with adult respiratory distress syndrome (ARDS) as part of a severe systemic inflammatory response syndrome caused by Still's disease. However, it is important to note that this is an indirect support because the primary focus of the statement is on Still's disease rather than ARDS itself. More direct evidence from randomized controlled trials would be needed for stronger support. + + To further elaborate on my response, let me first clarify some definitions. Adult acute respiratory distress syndrome (ARDS) is characterized by widespread inflammation in the lungs that can be caused by various direct (e.g., pneumonia) or indirect (e.g., sepsis) insults leading to non-cardiogenic pulmonary edema, hypoxemia, and reduced lung compliance (Force et al., 2012). Methylprednisolone is a corticosteroid often used in clinical settings for its potent" +7432980,Methylprednisolone treats myelodysplastic syndrome,1307,Eosinophilic fasciitis associated with autoimmune thyroid disease and myelodysplasia treated with pulsed methylprednisolone and antihistamines.,True,Is the triple 'Methylprednisolone treats myelodysplastic syndrome' supported by the sentence: 'Eosinophilic fasciitis associated with autoimmune thyroid disease and myelodysplasia treated with pulsed methylprednisolone and antihistamines.'?,"Yes, indirectly it does lend some support. The statement mentions that methylprednisolone was used in treating eosinophilic fasciitis associated with myelodysplasia (a type of myelodysplastic syndrome). This implies that methylprednisolone could potentially be an effective treatment option for myelodysplastic syndrome, as suggested by the initial phrase. However, it is important to note that eosinophilic fasciitis is not equivalent to myelodysplastic syndrome; they are two distinct conditions that happened to be present in this particular case. Therefore, while there is some indirect support for the use of methylprednisolone in treating myelodysplastic syndrome based on this statement alone, further evidence would be required before making any definitive conclusions about its efficacy in treating myelodysplastic syndrome specifically." +16097513,Cefotaxime treats osteomyelitis,1308,Cefotaxime in the treatment of chronic osteomyelitis caused by gram-negative bacilli.,True,Is the triple 'Cefotaxime treats osteomyelitis' supported by the sentence: 'Cefotaxime in the treatment of chronic osteomyelitis caused by gram-negative bacilli.'?,"Yes, the statement ""Cefotaxime in the treatment of chronic osteomyelitis caused by gram-negative bacilli"" does provide indirect support for the claim that ""Cefotaxime treats osteomyelitis."" Osteomyelitis is an infection of the bone, which can be caused by various types of bacteria including gram-negative bacilli. Cefotaxime is an antibiotic known to be effective against gram-negative bacilli. Therefore, it can be inferred that Cefotaxime can treat osteomyelitis when caused by gram-negative bacilli as indicated in the statement. However, it is important to note that osteomyelitis can also be caused by gram-positive bacteria and fungi, for which Cefotaxime may not be effective." +15119078,Cefotaxime treats peritonitis,1309,Aztreonam and cefotaxime were compared in 44 cirrhotic patients who had 52 episodes of gram-negative spontaneous peritonitis.,False,Is the triple 'Cefotaxime treats peritonitis' supported by the sentence: 'Aztreonam and cefotaxime were compared in 44 cirrhotic patients who had 52 episodes of gram-negative spontaneous peritonitis.'?,"No, the phrase ""Cefotaxime treats peritonitis"" does not receive direct support from the statement: ""Aztreonam and cefotaxime were compared in 44 cirrhotic patients who had 52 episodes of gram-negative spontaneous peritonitis."" + + The statement only indicates that cefotaxime was part of a comparative study involving patients with gram-negative spontaneous peritonitis. It does not explicitly state that cefotaxime treats peritonitis nor provide information on its efficacy compared to other treatments. To make a claim about cefotaxime treating peritonitis, there would need to be evidence demonstrating its causative relationship in treating peritonitis, which is not provided in this statement." +11176033,Cefotaxime treats Sepsis,1310,"Due to the apparent volumes of distribution obtained (ranging from 0.48 to 0.51 L/kg), considering the overall clinical efficacy obtained (90% for the 10 mg/kg dose and 75% for the 20 mg/kg dose), and due to the rapid improvement observed after a few doses of the drug (1.8 to 2.5 doses to 'clinical improvement'), it is safe to postulate such doses of cefotaxime as excellent choices for the treatment of septicaemia in dogs.",True,"Is the triple 'Cefotaxime treats Sepsis' supported by the sentence: 'Due to the apparent volumes of distribution obtained (ranging from 0.48 to 0.51 L/kg), considering the overall clinical efficacy obtained (90% for the 10 mg/kg dose and 75% for the 20 mg/kg dose), and due to the rapid improvement observed after a few doses of the drug (1.8 to 2.5 doses to 'clinical improvement'), it is safe to postulate such doses of cefotaxime as excellent choices for the treatment of septicaemia in dogs.'?","Yes, indirect support can be inferred from the statement for the phrase ""Cefotaxime treats Sepsis"" in dogs. The statement provides evidence that Cefotaxime has been observed to have clinical efficacy in treating septicaemia (a synonym for sepsis) in dogs, with 90% success rate for 10 mg/kg dose and 75% for 20 mg/kg dose. Additionally, rapid improvement was observed after a few doses (1.8-2.5), which suggests the effectiveness of the treatment. However, it is important to note that while there is support for Cefotaxime as an effective treatment for sepsis in dogs, the statement does not explicitly confirm that Cefotaxime treats sepsis; therefore, the support is indirect. + + The statement does not provide information about other potential treatments for sepsis in dogs, so no comparison can be made regarding Cefotaxime being superior or inferior to other treatments. Additionally, further studies would be required to confirm these results and ensure there are no adverse effects associated with" +8153267,Cefotaxime treats bacterial infectious disease,1311,These results suggest that amoxicillin-clavulanic acid is an effective alternative to cefotaxime for the empirical treatment of bacterial infections in cirrhosis.,False,Is the triple 'Cefotaxime treats bacterial infectious disease' supported by the sentence: 'These results suggest that amoxicillin-clavulanic acid is an effective alternative to cefotaxime for the empirical treatment of bacterial infections in cirrhosis.'?,"No, the statement does not provide direct or indirect support for the phrase ""Cefotaxime treats bacterial infectious disease"". The provided statement discusses an alternative treatment option (amoxicillin-clavulanic acid) to cefotaxime in specific circumstances (empirical treatment of bacterial infections in cirrhosis). This does not imply that cefotaxime is ineffective for treating bacterial infections but rather suggests that there might be an alternative option in certain situations." +26980543,Ceftriaxone treats Lyme disease,1312,"Most children had received prolonged and repeated courses of oral antimicrobials and/or home intravenous infusion of antimicrobials; 79% had been hospitalized for treatment of suspected LD or management of treatment complications, most notably drug-induced symptoms of gallbladder disease occurring in patients receiving ceftriaxone (Rocephin), and bloodstream infections associated with intravenous catheters.",False,"Is the triple 'Ceftriaxone treats Lyme disease' supported by the sentence: 'Most children had received prolonged and repeated courses of oral antimicrobials and/or home intravenous infusion of antimicrobials; 79% had been hospitalized for treatment of suspected LD or management of treatment complications, most notably drug-induced symptoms of gallbladder disease occurring in patients receiving ceftriaxone (Rocephin), and bloodstream infections associated with intravenous catheters.'?","No, the statement does not provide indirect support for the claim that Ceftriaxone treats Lyme disease (LD). The passage discusses the treatment complications experienced by children receiving Ceftriaxone (Rocephin) for suspected LD. The fact that many children were treated with Ceftriaxone does not imply that it is an effective treatment for Lyme disease; instead, it highlights the severity of complications arising from its use in these patients. + + To provide indirect support for the claim that Ceftriaxone treats Lyme disease, one would need evidence suggesting that patients improved upon receiving Ceftriaxone specifically for Lyme disease, not as a result of other treatments or interventions. The passage does not contain information about patients' responses to treatment; therefore, it cannot support the claim in question." +26401802,Ceftriaxone treats Sepsis,1313,"Clinical study of Rocephin, a 3d generation cephalosporin, in various septicaemias.",True,"Is the triple 'Ceftriaxone treats Sepsis' supported by the sentence: 'Clinical study of Rocephin, a 3d generation cephalosporin, in various septicaemias.'?","Yes, indirectly it does lend support. Rocephin is another name for Ceftriaxone, which is a third-generation cephalosporin antibiotic. The statement indicates that Rocephin has been studied in various septicaemias (a synonym for sepsis). Therefore, it can be inferred that Ceftriaxone has been investigated for its effectiveness in treating sepsis, even though the phrase ""Ceftriaxone treats Sepsis"" is not explicitly stated in the provided context. However, it is important to note that while this statement suggests Ceftriaxone may be used to treat sepsis, it does not provide direct evidence of its efficacy in such cases. Further investigation into clinical trial results and literature would be necessary for a more definitive conclusion on its therapeutic value in sepsis treatment." +18413392,Ceftriaxone treats bacterial pneumonia,1314,"The objectives of this open, prospective, randomized and comparative study were to evaluate and compare the efficacy and safety of intravenous ceftriaxone (active ingredient of Rocephin) and cefotaxime in treatment of bacterial pneumoniae.",True,"Is the triple 'Ceftriaxone treats bacterial pneumonia' supported by the sentence: 'The objectives of this open, prospective, randomized and comparative study were to evaluate and compare the efficacy and safety of intravenous ceftriaxone (active ingredient of Rocephin) and cefotaxime in treatment of bacterial pneumoniae.'?","Yes, the statement does provide indirect support for the phrase ""Ceftriaxone treats bacterial pneumonia."" The study mentioned in the statement is designed to evaluate and compare the efficacy and safety of intravenous ceftriaxone (an active ingredient in Rocephin) and cefotaxime in treating bacterial pneumoniae. This implies that ceftriaxone is being considered as a potential treatment for bacterial pneumonia, thereby lending indirect support to the claim that ceftriaxone can be used to treat bacterial pneumonia. However, it is important to note that actual evidence of ceftriaxone's efficacy in treating bacterial pneumonia would require further examination of the study results themselves, as the statement only describes the study objectives and does not provide any information on the outcomes or conclusions drawn from the study." +25810060,Gefarnate treats gastric ulcer,1315,Clinical trial of Gefarnate in the treatment of gastric ulcer disease.,True,Is the triple 'Gefarnate treats gastric ulcer' supported by the sentence: 'Clinical trial of Gefarnate in the treatment of gastric ulcer disease.'?,"Yes, the phrase ""Gefarnate treats gastric ulcer"" does receive indirect support from the statement: ""Clinical trial of Gefarnate in the treatment of gastric ulcer disease."" + + The reason for my affirmative response is that conducting a clinical trial implies that there is some degree of belief that the drug being tested (in this case, Gefarnate) has potential therapeutic benefits for the condition under investigation (gastric ulcer disease). A clinical trial typically involves rigorous testing and evaluation procedures that aim to establish whether a treatment is both safe and effective for its intended use. + + Therefore, even though the statement does not explicitly confirm that Gefarnate successfully treats gastric ulcers, it does provide evidence that researchers have investigated its potential in that context. This investigation lends credibility to the claim that Gefarnate may indeed have some positive impact on gastric ulcers, even if further studies are needed for definitive proof. + + Nonetheless, it is crucial to note that no definitive conclusions can be drawn without access to more detailed information about the clinical trial itself (such as its design, sample size, results, etc.). Ultimately, any claim regarding Gefarn" +25784688,Gefarnate treats duodenal ulcer,1316,[Clinicobiological evolution of duodenal ulcer treated with gefarnate].,True,Is the triple 'Gefarnate treats duodenal ulcer' supported by the sentence: '[Clinicobiological evolution of duodenal ulcer treated with gefarnate].'?,"Yes, the phrase ""Gefarnate treats duodenal ulcer"" does receive indirect support from the statement: ""[Clinicobiological evolution of duodenal ulcer treated with gefarnate]."" + + The title suggests that gefarnate is used in treating duodenal ulcers by implying causality between gefarnate administration and changes in duodenal ulcers over time (i.e., clinicobiological evolution). However, it is essential to note that direct causality cannot be definitively concluded without further information about the study design, results, and statistical analysis provided in the study itself. + + Nonetheless, based on the title alone, one can infer that gefarnate is being associated with treating duodenal ulcers in some capacity, providing indirect support for that claim." +19702373,Gefarnate treats peptic ulcer disease,1317,"One hundred and thirty-nine patients with endoscopically confirmed peptic ulcers (gastric and duodenal) entered a double blind comparative evaluation of alprazolam (1.2 mg/day), gefarnate (300 mg/day) and their combination in treatment of peptic ulcer.",True,"Is the triple 'Gefarnate treats peptic ulcer disease' supported by the sentence: 'One hundred and thirty-nine patients with endoscopically confirmed peptic ulcers (gastric and duodenal) entered a double blind comparative evaluation of alprazolam (1.2 mg/day), gefarnate (300 mg/day) and their combination in treatment of peptic ulcer.'?","Yes, the statement does provide indirect support for the claim that gefarnate treats peptic ulcer disease. The reason is that it mentions gefarnate (300 mg/day) being used in a double-blind comparative evaluation for treating peptic ulcers (gastric and duodenal). This implies that there is an interest in studying gefarnate as a potential treatment for peptic ulcers in a clinical setting. + + However, it is important to note that indirect support does not equate to definitive evidence that gefarnate is an effective treatment for peptic ulcer disease. The statement does not include information on the outcomes of the study, such as whether patients in the gefarnate group showed significant improvement compared to those in other groups (alprazolam and combination). Additionally, further factors such as side effects, long-term effects, and comparative efficacy should be taken into account before making any conclusions about gefarnate as an appropriate treatment for peptic ulcer disease." +22023951,Regadenoson treats coronary artery disorder,1318,CONCLUSIONS: Regadenoson may be a safe vasodilator for CTP and MR MPI in CAD patients.,True,Is the triple 'Regadenoson treats coronary artery disorder' supported by the sentence: 'CONCLUSIONS: Regadenoson may be a safe vasodilator for CTP and MR MPI in CAD patients.'?,"Yes, there is indirect support for the phrase ""Regadenoson treats coronary artery disorder"" in the statement ""CONCLUSIONS: Regadenoson may be a safe vasodilator for CTP (Computed Tomography Perfusion) and MR MPI (Myocardial Perfusion Imaging) in CAD (Coronary Artery Disease) patients."" + + Justification: + + Regadenoson is mentioned as a safe vasodilator in the context of CTP and MR MPI for CAD patients. A vasodilator is a substance that widens blood vessels, improving blood flow, which is crucial in treating coronary artery disorders like CAD. Therefore, if Regadenoson safely dilates coronary arteries during imaging procedures like CTP and MR MPI for CAD patients, it indirectly supports the claim that Regadenoson treats coronary artery disorders. + + However, it is essential to emphasize that while there is indirect support for Regadenoson treating coronary artery disorders based on its use as a safe vasodilator in CAD patients during imaging procedures, further investigation is necessary for more" +13297277,Meldonium treats Ischemic stroke,1319,A study is presented of the clinico-hemodynamic efficacy of mildronate in 38 patients with ischemic stroke.,False,Is the triple 'Meldonium treats Ischemic stroke' supported by the sentence: 'A study is presented of the clinico-hemodynamic efficacy of mildronate in 38 patients with ischemic stroke.'?,"No, the statement ""A study is presented of the clinico-hemodynamic efficacy of mildronate in 38 patients with ischemic stroke"" does not provide indirect support for the claim that ""Meldonium treats Ischemic stroke."" Meldonium is often marketed under the tradename mildronate; however, the study does not explicitly state that Meldonium (Meldonium being the active ingredient) is responsible for any observed clinico-hemodynamic efficacy in patients suffering from ischemic stroke. + + To provide indirect support for the claim that ""Meldonium treats Ischemic stroke,"" additional information would be required linking Meldonium specifically (not merely mildronate as a tradename) to any observed benefits in patients suffering from ischemic stroke. This could be achieved through further analysis of the study in question (for example, checking if Meldonium is mentioned as an active ingredient in the treatment), looking at other relevant studies, or consulting expert opinions in the field. + + In summary, while it is possible that Meldonium may have beneficial effects for patients suffering from ischemic stroke based on this" +25624167,Neobiotic treats pneumonia,1320,Use of neomycin for treatment of Rhodococcus equi pneumonia in foals.,True,Is the triple 'Neobiotic treats pneumonia' supported by the sentence: 'Use of neomycin for treatment of Rhodococcus equi pneumonia in foals.'?,"Yes, indirectly it does lend some support. The statement suggests that neomycin is used in treating pneumonia caused by Rhodococcus equi in foals. However, this does not necessarily mean that neobiotic (which is a class of antibiotics including neomycin) as a whole treats pneumonia, but it does imply that neomycin, as part of the neobiotic class, has been used effectively for such treatment. Therefore, while not direct evidence, it does provide some indirect support for the claim that ""Neobiotic treats pneumonia""." +11022701,Neobiotic treats bacterial infectious disease with sepsis,1321,Osteomyelitis of the cervical vertebras as a complication of urinary tract disease; Proteus bacteremia treated with neomycin.,True,Is the triple 'Neobiotic treats bacterial infectious disease with sepsis' supported by the sentence: 'Osteomyelitis of the cervical vertebras as a complication of urinary tract disease; Proteus bacteremia treated with neomycin.'?,"Yes, indirectly it does support that statement because Neobiotic is an antibiotic (neomycin in this case) which is used to treat bacterial infections. Sepsis is a serious complication of bacterial infection that can occur when an overwhelming immune response triggered by an infection injures tissues and organs throughout the body. In the provided context, Proteus bacteremia (bacteria in the blood) was treated with neomycin, which suggests that Neobiotic could be used for treating bacterial infectious diseases associated with sepsis as well. However, it is important to note that direct evidence for Neobiotic treating sepsis is not provided in this statement; hence it is an indirect inference based on the known properties and uses of neomycin as an antibiotic." +24398401,BLINATUMOMAB treats B-cell chronic lymphocytic leukemia,1322,Lineage Conversion in Pediatric B-Cell Precursor Acute Leukemia under Blinatumomab Therapy.,False,Is the triple 'BLINATUMOMAB treats B-cell chronic lymphocytic leukemia' supported by the sentence: 'Lineage Conversion in Pediatric B-Cell Precursor Acute Leukemia under Blinatumomab Therapy.'?,"No, the phrase ""BLINATUMOMAB treats B-cell chronic lymphocytic leukemia"" does not receive indirect support from the statement: ""Lineage Conversion in Pediatric B-Cell Precursor Acute Leukemia under Blinatumomab Therapy."" The statement only suggests that Blinatumomab may induce lineage conversion in pediatric B-cell precursor acute leukemia, which is different from chronic lymphocytic leukemia (B-CLL). + + B-cell chronic lymphocytic leukemia (B-CLL) is a distinct type of leukemia that typically affects older adults, whereas acute lymphoblastic leukemia (ALL) is more common in children. Blinatumomab is an immunotherapy drug designed to target CD19-positive cells in leukemia; however, its effectiveness is mainly studied in treating acute lymphoblastic leukemia (ALL) rather than chronic lymphocytic leukemia (B-CLL). + + Therefore" +23073290,BLINATUMOMAB treats Precursor B-Cell Lymphoblastic Leukemia-Lymphoma,1323,"We report on the Australian experience of blinatumomab for treatment of 24 children with relapsed/refractory precursor B-cell acute lymphoblastic leukaemia (B-ALL) and high-risk genetics, resulting in a minimal residual disease (MRD) response rate of 58%, 2-year progression-free survival (PFS) of 39% and 2-year overall survival of 63%.",True,"Is the triple 'BLINATUMOMAB treats Precursor B-Cell Lymphoblastic Leukemia-Lymphoma' supported by the sentence: 'We report on the Australian experience of blinatumomab for treatment of 24 children with relapsed/refractory precursor B-cell acute lymphoblastic leukaemia (B-ALL) and high-risk genetics, resulting in a minimal residual disease (MRD) response rate of 58%, 2-year progression-free survival (PFS) of 39% and 2-year overall survival of 63%.'?","Yes, the statement does provide indirect support for the claim that blinatumomab treats Precursor B-Cell Lymphoblastic Leukemia-Lymphoma (B-ALL). The report details a study conducted on 24 children with relapsed/refractory B-ALL and high-risk genetics who were treated with blinatumomab. The results showed that 58% of these patients achieved minimal residual disease (MRD) response, and 2-year progression-free survival (PFS) and overall survival were 39% and 63%, respectively. These positive outcomes suggest that blinatumomab has been effective in treating these patients with B-ALL, providing evidence for its utility in managing this type of cancer. However, it is important to note that this evidence is derived from an observational study in a specific population; further investigation through randomized controlled trials is necessary to establish more robust evidence for blinatumomab's efficacy in treating B-ALL." +21932754,BLINATUMOMAB treats acute lymphoblastic leukemia,1324,"Blinatumomab for Acute Lymphoblastic Leukemia: The First Bispecific T-Cell Engager Antibody to Be Approved by the EMA for Minimal Residual Disease.On November 15, 2018, the Committee for Medicinal Products for Human Use (CHMP) recommended the extension of indication for blinatumomab to include the treatment of adults with minimal residual disease (MRD) positive B-cell precursor acute lymphoblastic leukemia (ALL).",True,"Is the triple 'BLINATUMOMAB treats acute lymphoblastic leukemia' supported by the sentence: 'Blinatumomab for Acute Lymphoblastic Leukemia: The First Bispecific T-Cell Engager Antibody to Be Approved by the EMA for Minimal Residual Disease.On November 15, 2018, the Committee for Medicinal Products for Human Use (CHMP) recommended the extension of indication for blinatumomab to include the treatment of adults with minimal residual disease (MRD) positive B-cell precursor acute lymphoblastic leukemia (ALL).'?","Yes, the statement does provide indirect support for the claim that Blinatumomab treats acute lymphoblastic leukemia (ALL). The statement indicates that Blinatumomab has been approved by the European Medicines Agency (EMA) for the treatment of adults with minimal residual disease (MRD) positive B-cell precursor acute lymphoblastic leukemia (ALL). This suggests that Blinatumomab is an effective treatment for ALL, particularly in cases where minimal residual disease is present. However, it is important to note that this is an indirect inference, as the statement does not explicitly state that Blinatumomab treats ALL, but rather that it is approved for use in treating ALL patients with MRD." +21720587,BLINATUMOMAB treats lymphoma,1325,"Cytokine storm was reported in four patients (19%).In conclusion, treatment with blinatumomab is effective and tolerable in adult patients with relapsed/refractory B-ALL outside of a clinical trial stetting.",True,"Is the triple 'BLINATUMOMAB treats lymphoma' supported by the sentence: 'Cytokine storm was reported in four patients (19%).In conclusion, treatment with blinatumomab is effective and tolerable in adult patients with relapsed/refractory B-ALL outside of a clinical trial stetting.'?","Yes, indirectly it does lend support. The statement mentions that treatment with blinatumomab is effective and tolerable in adult patients with relapsed/refractory B-ALL outside of a clinical trial setting, which implies that blinatumomab has therapeutic effects against B-ALL, a type of lymphoma. However, direct support would require a specific mention of blinatumomab treating lymphoma. Nevertheless, given that B-ALL is a type of lymphoma, it can be inferred that blinatumomab treats lymphoma indirectly." +9387116,Ciprofloxacin physically interacts with DNA Gyrase,1326,"UNLABELLED: Ciprofloxacin, a quinolone antibiotic drug, binds to DNA topoisomerase IV and DNA gyrase of various bacteria.",True,"Is the triple 'Ciprofloxacin physically interacts with DNA Gyrase' supported by the sentence: 'UNLABELLED: Ciprofloxacin, a quinolone antibiotic drug, binds to DNA topoisomerase IV and DNA gyrase of various bacteria.'?","Yes, the phrase ""Ciprofloxacin physically interacts with DNA Gyrase"" does receive indirect support from the statement: ""UNLABELLED: Ciprofloxacin, a quinolone antibiotic drug, binds to DNA topoisomerase IV and DNA gyrase of various bacteria."" + + + The statement indicates that Ciprofloxacin binds to DNA gyrase in various bacteria. The term ""binds"" implies some form of physical interaction between Ciprofloxacin and DNA gyrase. Although the statement does not explicitly mention ""physical interaction,"" it can be inferred that such an interaction occurs based on the information provided. + + + However, it is important to note that while binding often leads to some form of interaction, it does not necessarily mean that there is a direct physical interaction in the sense that one molecule is mechanically intertwined with another. In this case, Ciprofloxacin is likely interfering with the function of DNA gyrase enzymes by binding near their active sites, thereby inhibiting their activity without physically attaching in a mechanically" +8212496,Ciprofloxacin physically interacts with DNA Gyrase,1327,Topoisomerase IV and DNA gyrase were purified from a ciprofloxacin-sensitive Streptococcus pneumoniae strain and from two clinical isolates of S. pneumoniae with high-level resistance to ciprofloxacin by means of a gene cloning method in Escherichia coli.,False,Is the triple 'Ciprofloxacin physically interacts with DNA Gyrase' supported by the sentence: 'Topoisomerase IV and DNA gyrase were purified from a ciprofloxacin-sensitive Streptococcus pneumoniae strain and from two clinical isolates of S. pneumoniae with high-level resistance to ciprofloxacin by means of a gene cloning method in Escherichia coli.'?,"No, the statement does not provide direct support for the phrase ""Ciprofloxacin physically interacts with DNA Gyrase."" While it does mention that Ciprofloxacin is an antibiotic that affects S. pneumoniae strains (sensitive and resistant) by interacting with topoisomerase IV and DNA gyrase (enzymes involved in DNA replication), it does not explicitly state that Ciprofloxacin physically interacts with DNA Gyrase in vivo or in vitro. + + However, indirect support might be inferred from established knowledge about Ciprofloxacin as a fluoroquinolone antibiotic that inhibits bacterial DNA gyrase (topoisomerase II) by stabilizing the covalent DNA-enzyme complex (cleavable complex), leading to double-strand DNA breaks and bacterial cell death [1]. + + + + In summary, while there is no direct evidence in the statement provided for Ciprofloxacin physically interacting with DNA Gyrase, such an interaction is consistent with existing knowledge about Ciproflo" +7781719,Ciprofloxacin affects DNA Gyrase,1328,"The concentrations of ciprofloxacin, sparfloxacin, levofloxacin, or ofloxacin required to inhibit wild-type topoisomerase IV were 8 to 16 times lower than those required to inhibit wild-type DNA gyrase.",True,"Is the triple 'Ciprofloxacin affects DNA Gyrase' supported by the sentence: 'The concentrations of ciprofloxacin, sparfloxacin, levofloxacin, or ofloxacin required to inhibit wild-type topoisomerase IV were 8 to 16 times lower than those required to inhibit wild-type DNA gyrase.'?","Yes, the statement does provide indirect support for the phrase ""Ciprofloxacin affects DNA Gyrase"". The statement implies that ciprofloxacin has an effect on topoisomerase IV, which is a type of enzyme that controls DNA supercoiling - a process closely related to DNA gyrase. DNA gyrase is another type of topoisomerase that introduces negative supercoils into DNA during replication and transcription. Both topoisomerase IV and DNA gyrase belong to the family of enzymes called topoisomerases that control and alter the topological states of DNA during various cellular processes. + + The fact that ciprofloxacin inhibits wild-type topoisomerase IV at lower concentrations than those required for DNA gyrase inhibition suggests that ciprofloxacin has some level of interaction with DNA gyrase as well. This is because both enzymes share structural similarities and functional mechanisms despite their differences in substrate specificity and cellular roles. Therefore, it is plausible that ciprofloxacin affects DNA gyrase either directly by binding to" +18400322,Ciprofloxacin affects DNA Gyrase,1329,Plasmid-encoded protein QnrB1 protects DNA gyrase from ciprofloxacin inhibition.,True,Is the triple 'Ciprofloxacin affects DNA Gyrase' supported by the sentence: 'Plasmid-encoded protein QnrB1 protects DNA gyrase from ciprofloxacin inhibition.'?,"Yes, the statement does provide indirect support for the phrase ""Ciprofloxacin affects DNA Gyrase."" The provided information indicates that plasmid-encoded protein QnrB1 protects DNA gyrase from ciprofloxacin inhibition. This implies that ciprofloxacin typically inhibits DNA gyrase, as there would be no need for protection if it did not have that effect. Therefore, it suggests that ciprofloxacin does indeed affect DNA gyrase. + + However, it is important to note that while this statement provides indirect evidence for ciprofloxacin affecting DNA gyrase, it does not necessarily prove causation nor does it provide direct evidence for the mechanism by which ciprofloxacin impacts DNA gyrase. Further investigation would be required to confirm these details." +24010235,Ciprofloxacin treats chronic bronchitis,1330,"Thirty four patients with acute purulent exacerbations of chronic bronchitis were treated with 500 mg ciprofloxacin twice daily, orally, for ten days.",True,"Is the triple 'Ciprofloxacin treats chronic bronchitis' supported by the sentence: 'Thirty four patients with acute purulent exacerbations of chronic bronchitis were treated with 500 mg ciprofloxacin twice daily, orally, for ten days.'?","Yes, indirectly it does lend some support to the statement ""Ciprofloxacin treats chronic bronchitis"". The provided evidence states that 34 patients with acute purulent exacerbations of chronic bronchitis were treated with Ciprofloxacin for ten days. This implies that Ciprofloxacin was used as a treatment for these patients suffering from chronic bronchitis exacerbations, which can be considered supportive evidence that Ciprofloxacin is used in treating chronic bronchitis in some capacity. However, it is essential to note that this is indirect evidence; it does not explicitly demonstrate that Ciprofloxacin can cure chronic bronchitis but rather that it might be an option for treating its complications (acute purulent exacerbations). Additionally, it would be important to consider other factors such as potential side effects, efficacy compared to other treatment options, and whether long-term use is recommended before making definitive conclusions about Ciprofloxacin as a treatment for chronic bronchitis." +22484062,Ciprofloxacin treats amyotrophic lateral sclerosis,1331,"OBJECTIVE: To evaluate the efficacy of a fixed-dose combination of two approved drugs, Ciprofloxacin and Celecoxib, as a potential therapeutic treatment for amyotrophic lateral sclerosis (ALS).",False,"Is the triple 'Ciprofloxacin treats amyotrophic lateral sclerosis' supported by the sentence: 'OBJECTIVE: To evaluate the efficacy of a fixed-dose combination of two approved drugs, Ciprofloxacin and Celecoxib, as a potential therapeutic treatment for amyotrophic lateral sclerosis (ALS).'?","No, the statement does not provide any direct support for the claim that ""Ciprofloxacin treats amyotrophic lateral sclerosis."" The objective in question is investigating the efficacy of a combination therapy that includes Ciprofloxacin for treating ALS, not Ciprofloxacin in isolation. This suggests that the researchers might believe that Ciprofloxacin could have some therapeutic potential in treating ALS as part of a combination treatment but does not confirm its efficacy as a standalone treatment for ALS. The statement also does not provide any indirect evidence for Ciprofloxacin's efficacy in treating ALS since it only mentions an ongoing evaluation without presenting any results or outcomes from studies on Ciprofloxacin as an ALS treatment." +21488232,Ciprofloxacin treats Infection,1332,Noncytotoxic Pyrrolobenzodiazepine-Ciprofloxacin Conjugate with Activity against Mycobacterium tuberculosis .The development of new antitubercular agents for the treatment of infections caused by multidrug-resistant (MDR) Mycobacterium tuberculosis is an urgent priority.,False,Is the triple 'Ciprofloxacin treats Infection' supported by the sentence: 'Noncytotoxic Pyrrolobenzodiazepine-Ciprofloxacin Conjugate with Activity against Mycobacterium tuberculosis .The development of new antitubercular agents for the treatment of infections caused by multidrug-resistant (MDR) Mycobacterium tuberculosis is an urgent priority.'?,"No, the phrase ""Ciprofloxacin treats Infection"" does not receive direct support from the statement provided. The statement discusses the development of a new antitubercular agent, specifically a noncytotoxic Pyrrolobenzodiazepine-Ciprofloxacin Conjugate, for treating infections caused by multidrug-resistant Mycobacterium tuberculosis. However, it does not confirm that Ciprofloxacin alone treats infections. Indirectly, it suggests that Ciprofloxacin may be useful in conjunction with other agents for treating certain types of infections, but it does not provide direct evidence that Ciprofloxacin is an effective standalone treatment for any infection." +20040173,Ciprofloxacin treats lymphoma,1333,Antibacterial prophylaxis with ciprofloxacin for patients with multiple myeloma and lymphoma undergoing autologous haematopoietic cell transplantation: a quasi-experimental single-centre before-after study.,False,Is the triple 'Ciprofloxacin treats lymphoma' supported by the sentence: 'Antibacterial prophylaxis with ciprofloxacin for patients with multiple myeloma and lymphoma undergoing autologous haematopoietic cell transplantation: a quasi-experimental single-centre before-after study.'?,"No, the phrase ""Ciprofloxacin treats lymphoma"" does not receive indirect support from the statement: ""Antibacterial prophylaxis with ciprofloxacin for patients with multiple myeloma and lymphoma undergoing autologous haematopoietic cell transplantation: a quasi-experimental single-centre before-after study."" + + The study mentioned is investigating the effectiveness of administering ciprofloxacin as an antibacterial prophylaxis for patients undergoing autologous haematopoietic cell transplantation who have multiple myeloma or lymphoma. The purpose is to prevent bacterial infections during the transplantation process rather than treating lymphoma itself. + + The misconception may arise from conflating treating bacterial infections (for which ciprofloxacin is effective) that lymphoma patients might experience during transplantation with treating lymphoma itself. Ciprofloxacin is an antibiotic that is not indicated for treating lymphoma; instead, chemotherapy regimens along" +19067853,Ciprofloxacin treats B-cell chronic lymphocytic leukemia,1334,A case of septic arthritis caused by a Mycoplasma salivarium strain resistant towards Ciprofloxacin and Clarithromycin in a patient with chronic lymphatic leukemia.,False,Is the triple 'Ciprofloxacin treats B-cell chronic lymphocytic leukemia' supported by the sentence: 'A case of septic arthritis caused by a Mycoplasma salivarium strain resistant towards Ciprofloxacin and Clarithromycin in a patient with chronic lymphatic leukemia.'?,"No, the statement does not provide indirect support for the claim that Ciprofloxacin treats B-cell chronic lymphocytic leukemia (B-CLL). The statement describes a case where a patient with B-CLL developed septic arthritis caused by a Ciprofloxacin-resistant strain of Mycoplasma salivarium. The fact that Ciprofloxacin was ineffective against this specific bacterial infection in an individual with B-CLL does not imply that Ciprofloxacin has therapeutic effects on B-CLL itself. + + B-CLL is a type of cancer affecting white blood cells (B-lymphocytes), while Ciprofloxacin is an antibiotic used primarily for treating bacterial infections by inhibiting DNA gyrase, thereby interfering with bacterial DNA replication. Antibiotics like Ciprofloxacin have no direct therapeutic effect on cancer cells; thus, there is no reason to infer that Ciprofloxacin would be useful in treating B-CLL based on" +14572951,Ciprofloxacin treats hearing loss disorder,1335,Treatment with ciprofloxacin and ceftazidime improved the hearing loss significantly.,False,Is the triple 'Ciprofloxacin treats hearing loss disorder' supported by the sentence: 'Treatment with ciprofloxacin and ceftazidime improved the hearing loss significantly.'?,"No, the phrase ""Ciprofloxacin treats hearing loss disorder"" does not receive direct support from the statement: ""Treatment with ciprofloxacin and ceftazidime improved the hearing loss significantly."" + + + The statement only indicates that there was an improvement in hearing loss when both ciprofloxacin and ceftazidime were used together. It does not specify whether ciprofloxacin alone was responsible for the improvement in hearing loss or if ceftazidime played a role as well. Therefore, it is inappropriate to make a definitive claim about ciprofloxacin treating hearing loss disorder based solely on this evidence. Further investigation would be required to determine the specific effects of ciprofloxacin on hearing loss disorder." +14398199,Ciprofloxacin treats sinusitis,1336,"CASE SUMMARY: A 24-year-old woman was admitted to the hospital because of convulsions, severe myopathy, and acute renal failure after taking ciprofloxacin for sinusitis, and urinary tract infections.",False,"Is the triple 'Ciprofloxacin treats sinusitis' supported by the sentence: 'CASE SUMMARY: A 24-year-old woman was admitted to the hospital because of convulsions, severe myopathy, and acute renal failure after taking ciprofloxacin for sinusitis, and urinary tract infections.'?","No, the statement does not provide indirect support for the claim that ""Ciprofloxacin treats sinusitis."" In fact, it suggests quite the opposite: that ciprofloxacin may have severe side effects in some patients when used to treat sinusitis. This is an important distinction because while ciprofloxacin can be used to treat certain types of bacterial infections (including some cases of sinusitis), it does not necessarily follow that taking ciprofloxacin for sinusitis will always be safe or effective for every patient. + + The case summary describes adverse reactions experienced by a patient who took ciprofloxacin for both sinusitis and urinary tract infections. While ciprofloxacin might have been appropriate for treating her urinary tract infection (assuming she had a bacterial infection sensitive to ciprofloxacin), its use in treating her sinusitis appears to have resulted in severe side effects. Therefore, one could argue that ciprofloxacin is not an ideal treatment for sinusitis in this particular case. + + It is essential for healthcare providers" +14311974,Ciprofloxacin treats liver abscess (disease),1337,Chromobacterium violaceum endocarditis and hepatic abscesses treated successfully with meropenem and ciprofloxacin.,True,Is the triple 'Ciprofloxacin treats liver abscess (disease)' supported by the sentence: 'Chromobacterium violaceum endocarditis and hepatic abscesses treated successfully with meropenem and ciprofloxacin.'?,"Yes, indirect support can be inferred from the statement ""Chromobacterium violaceum endocarditis and hepatic abscesses treated successfully with meropenem and ciprofloxacin."" + + + + The statement implies that ciprofloxacin was part of a successful treatment regimen for hepatic abscesses caused by Chromobacterium violaceum. However, it does not explicitly state that ciprofloxacin alone treats liver abscesses (disease). The treatment success may be attributed to the combination of meropenem and ciprofloxacin, or other factors such as surgical interventions that were not specified in the statement. Therefore, while there is some level of indirect support for the claim, it is not definitive proof that ciprofloxacin is an effective sole treatment for liver abscesses caused by any organism." +14284683,Ciprofloxacin treats gastroenteritis,1338,"A patient is reported who had previously maintained a stable prothrombin time on Coumadin for 5 years, and who exhibited a marked prolongation of prothrombin time when placed on ciprofloxacin for gastroenteritis.",False,"Is the triple 'Ciprofloxacin treats gastroenteritis' supported by the sentence: 'A patient is reported who had previously maintained a stable prothrombin time on Coumadin for 5 years, and who exhibited a marked prolongation of prothrombin time when placed on ciprofloxacin for gastroenteritis.'?","No, the statement does not provide indirect support for the claim that ""Ciprofloxacin treats gastroenteritis."" The statement describes an incident where a patient on Coumadin developed a prolonged prothrombin time after being administered Ciprofloxacin for gastroenteritis. However, it does not suggest any therapeutic benefit of Ciprofloxacin for treating gastroenteritis. In fact, it implies that Ciprofloxacin may interact negatively with other medications like Coumadin." +14141218,Ciprofloxacin treats castration-resistant prostate carcinoma,1339,"Doxorubicin and docetaxel, two standard antineoplastic agents in hormone-refractory prostate cancer (HRPC) therapy and ciprofloxacin were evaluated singly and in several simultaneous and sequential drug combination schemes, against PC-3 and LNCaP cell lines.",False,"Is the triple 'Ciprofloxacin treats castration-resistant prostate carcinoma' supported by the sentence: 'Doxorubicin and docetaxel, two standard antineoplastic agents in hormone-refractory prostate cancer (HRPC) therapy and ciprofloxacin were evaluated singly and in several simultaneous and sequential drug combination schemes, against PC-3 and LNCaP cell lines.'?","No, the statement does not provide direct support for the claim that ""Ciprofloxacin treats castration-resistant prostate carcinoma"". The study mentioned in the statement is investigating the effects of ciprofloxacin in combination with other agents (doxorubicin and docetaxel) on PC-3 and LNCaP cell lines. However, it does not explicitly state that ciprofloxacin alone is effective in treating castration-resistant prostate carcinoma. Further investigation would be required to establish such a claim." +14005051,Ciprofloxacin treats acute myeloid leukemia,1340,"Results of combination therapy with amifostine, pentoxifylline, ciprofloxacin and dexamethasone in patients with myelodysplastic syndrome and acute myeloid leukemia.",False,"Is the triple 'Ciprofloxacin treats acute myeloid leukemia' supported by the sentence: 'Results of combination therapy with amifostine, pentoxifylline, ciprofloxacin and dexamethasone in patients with myelodysplastic syndrome and acute myeloid leukemia.'?","No, the phrase ""Ciprofloxacin treats acute myeloid leukemia"" does not receive indirect support from the statement: ""Results of combination therapy with amifostine, pentoxifylline, ciprofloxacin and dexamethasone in patients with myelodysplastic syndrome and acute myeloid leukemia."" + + + The statement provides evidence that ciprofloxacin is used in combination therapy for myelodysplastic syndrome and acute myeloid leukemia patients. However, it does not indicate that ciprofloxacin has any therapeutic effect on acute myeloid leukemia when used independently. In fact, ciprofloxacin is an antibiotic primarily used for treating bacterial infections, rather than being an anticancer drug used for treating leukemia. Therefore, no indirect support can be inferred for ciprofloxacin as an independent treatment for acute myeloid leukemia from this statement alone." +13846017,Ciprofloxacin treats lung disorder,1341,High dose parenteral ciprofloxacin in pleuro-pulmonary disease: a comparative pharmacolinetics of 400 and 200 mg intravenous.,False,Is the triple 'Ciprofloxacin treats lung disorder' supported by the sentence: 'High dose parenteral ciprofloxacin in pleuro-pulmonary disease: a comparative pharmacolinetics of 400 and 200 mg intravenous.'?,"No, the statement ""High dose parenteral ciprofloxacin in pleuro-pulmonary disease: a comparative pharmacokinetics of 400 and 200 mg intravenous"" does not provide direct or indirect support for the claim that ""Ciprofloxacin treats lung disorder."" + + The statement in question is a comparative pharmacokinetics study on high-dose parenteral ciprofloxacin in pleuro-pulmonary disease, which primarily focuses on how ciprofloxacin is absorbed, distributed, metabolized, and excreted in the body when administered intravenously at doses of 400 mg and 200 mg in patients with pleuro-pulmonary disease. + + While it is true that ciprofloxacin is an antibiotic often used for treating various bacterial infections in the body (including some respiratory infections), the provided statement does not offer any information on ciprofloxacin's clinical efficacy in treating lung disorders. Therefore, it is in" +13663890,Ciprofloxacin treats otitis media,1342,[Pneumococcal meningitis during ciprofloxacin therapy for otitis media].,False,Is the triple 'Ciprofloxacin treats otitis media' supported by the sentence: '[Pneumococcal meningitis during ciprofloxacin therapy for otitis media].'?,"No, the statement ""Pneumococcal meningitis during ciprofloxacin therapy for otitis media"" does not provide indirect support for the claim that ""Ciprofloxacin treats otitis media."" The statement describes an instance where pneumococcal meningitis occurred during ciprofloxacin therapy for otitis media, but it does not provide any information about the effectiveness of ciprofloxacin in treating otitis media. + + The statement actually suggests potential complications during ciprofloxacin treatment for otitis media since pneumococcal meningitis is a serious bacterial infection that can affect the membranes covering the brain and spinal cord. The fact that pneumococcal meningitis occurred during treatment might imply that ciprofloxacin was not effective in preventing such complications in this particular case; however, it does not disprove its potential therapeutic benefits for otitis media when used under appropriate circumstances in other individuals. + + To establish indirect support for ""Ciprofloxacin treats otitis media,"" one would need contextual evidence suggesting that treatment led" +11840711,Ciprofloxacin treats cataract,1343,"CONCLUSIONS: Ofloxacin has higher corneal penetration and ability to exceed MIC90 of common ocular contaminants than ciprofloxacin, and would be a more appropriate prophylactic choice for canine cataract patients.",False,"Is the triple 'Ciprofloxacin treats cataract' supported by the sentence: 'CONCLUSIONS: Ofloxacin has higher corneal penetration and ability to exceed MIC90 of common ocular contaminants than ciprofloxacin, and would be a more appropriate prophylactic choice for canine cataract patients.'?","No, the statement does not provide indirect support for the claim that ""Ciprofloxacin treats cataract."" The conclusion drawn in the statement is about Ofloxacin being a more appropriate prophylactic choice for canine cataract patients due to its higher corneal penetration and ability to exceed MIC90 of common ocular contaminants compared to Ciprofloxacin. This statement is actually suggesting that Ofloxacin may be more effective in preventing infections related to cataract surgery in dogs, not that Ciprofloxacin has any direct therapeutic effect on cataracts itself." +11684450,Ciprofloxacin treats cystitis,1344,Amoxicillin-clavulanate vs ciprofloxacin for the treatment of uncomplicated cystitis in women: a randomized trial.,True,Is the triple 'Ciprofloxacin treats cystitis' supported by the sentence: 'Amoxicillin-clavulanate vs ciprofloxacin for the treatment of uncomplicated cystitis in women: a randomized trial.'?,"Yes, the statement ""Ciprofloxacin treats cystitis"" does receive indirect support from the title ""Amoxicillin-clavulanate vs ciprofloxacin for the treatment of uncomplicated cystitis in women: a randomized trial."" This is because ciprofloxacin is explicitly mentioned as one of the treatment options being compared for uncomplicated cystitis in women within the context of a randomized trial - an experimental design that is considered the gold standard for clinical trials investigating treatment efficacy. + + However, it is important to note that while ciprofloxacin is being compared in this trial, it does not necessarily mean that it is proven to be effective in treating cystitis in women based solely on this information alone. The results and specific outcomes from such studies must be thoroughly analyzed before making any conclusions about treatment efficacy. Additionally, ciprofloxacin is known to have certain side effects and potential risks (such as contributing to antibiotic resistance), so its use should be carefully considered in light of these factors as well." +11679354,Ciprofloxacin treats Pseudomonas infection,1345,We used a simple Wood's light examination and culture to establish the diagnosis of Pseudomonas toe web infection and achieved rapid resolution with oral ciprofloxacin treatment and local application of Castellani's paint.,True,Is the triple 'Ciprofloxacin treats Pseudomonas infection' supported by the sentence: 'We used a simple Wood's light examination and culture to establish the diagnosis of Pseudomonas toe web infection and achieved rapid resolution with oral ciprofloxacin treatment and local application of Castellani's paint.'?,"Yes, the statement does provide indirect support for the phrase ""Ciprofloxacin treats Pseudomonas infection"". The statement mentions that oral ciprofloxacin treatment was used in conjunction with local application of Castellani's paint to achieve rapid resolution of a Pseudomonas toe web infection. This suggests that ciprofloxacin was effective in treating the infection caused by Pseudomonas, which aligns with the claim that ciprofloxacin can be used to treat Pseudomonas infections. However, it is important to note that this is an observational case report and does not provide the same level of evidence as a controlled clinical trial. Therefore, while it suggests efficacy, it does not definitively prove it." +11628762,Ciprofloxacin treats endophthalmitis,1346,Ciprofloxacin in endophthalmitis: an alternative to ceftazidime and amikacin!,True,Is the triple 'Ciprofloxacin treats endophthalmitis' supported by the sentence: 'Ciprofloxacin in endophthalmitis: an alternative to ceftazidime and amikacin!'?,"Yes, the statement ""Ciprofloxacin in endophthalmitis: an alternative to ceftazidime and amikacin!"" does provide indirect support for the claim that ""Ciprofloxacin treats endophthalmitis."" The title suggests that ciprofloxacin is being considered as an alternative treatment option for endophthalmitis, which implies that it has some efficacy in treating this condition. However, it is important to note that indirect support does not equate to definitive proof, and further investigation would be needed to establish the full extent of ciprofloxacin's therapeutic potential for endophthalmitis." +11564697,Ciprofloxacin treats chronic obstructive pulmonary disease,1347,Reported here is the case of a patient with underlying chronic obstructive pulmonary disease (COPD) in whom ciprofloxacin treatment of a lower respiratory tract infection failed subsequent to ciprofloxacin treatment of an exacerbation of COPD several weeks earlier.,False,Is the triple 'Ciprofloxacin treats chronic obstructive pulmonary disease' supported by the sentence: 'Reported here is the case of a patient with underlying chronic obstructive pulmonary disease (COPD) in whom ciprofloxacin treatment of a lower respiratory tract infection failed subsequent to ciprofloxacin treatment of an exacerbation of COPD several weeks earlier.'?,"No, the statement does not provide indirect support for the claim that ciprofloxacin treats chronic obstructive pulmonary disease (COPD). In fact, it suggests quite the opposite: ciprofloxacin was ineffective in treating a lower respiratory tract infection in a patient with COPD, who had previously been treated with ciprofloxacin for an exacerbation of COPD several weeks earlier. + + Ciprofloxacin is an antibiotic commonly used for treating various bacterial infections but has not been established as a standard treatment for COPD itself. COPD is primarily managed through bronchodilators, corticosteroids, and pulmonary rehabilitation rather than antibiotics like ciprofloxacin. The statement highlights a case where ciprofloxacin did not produce the desired outcome in treating infections in a patient with COPD. + + In summary, not only does the statement not indirectly support ciprofloxacin as a treatment for COPD, but it also raises questions about its efficacy in treating respiratory infections in patients suffering from" +11304087,Ciprofloxacin treats eye infectious disorder,1348,This PK-MB model may be very useful in optimizing treatments of various eye infections with ciprofloxacin.,True,Is the triple 'Ciprofloxacin treats eye infectious disorder' supported by the sentence: 'This PK-MB model may be very useful in optimizing treatments of various eye infections with ciprofloxacin.'?,"Yes, indirect support can be inferred from the statement. The PK-MB model mentioned refers to pharmacokinetic-pharmacodynamic (PK-PD) modeling, which is used in optimizing drug treatments by understanding how a drug is absorbed, distributed, metabolized, and excreted (pharmacokinetics) in relation to its effects on living organisms (pharmacodynamics). In this context, if the PK-MB model is useful in optimizing ciprofloxacin treatments for various eye infections, it implies that ciprofloxacin has some therapeutic effect on eye infections. Therefore, one could infer indirect support for the claim that ""Ciprofloxacin treats eye infectious disorder."" However, it is important to note that further investigation would be required for direct support since this statement does not explicitly mention ciprofloxacin's therapeutic effect on eye infections but rather its optimization through PK-PD modeling." +11059709,Ciprofloxacin treats abscess,1349,"The patient was asymptomatic for a month, but the abscess reactivated and was treated with Vancomycin and Ciprofloxacin administered intravenously.",True,"Is the triple 'Ciprofloxacin treats abscess' supported by the sentence: 'The patient was asymptomatic for a month, but the abscess reactivated and was treated with Vancomycin and Ciprofloxacin administered intravenously.'?","Yes, the statement does provide indirect support for the phrase ""Ciprofloxacin treats abscess"". The patient had an abscess that was initially asymptomatic but later reactivated. The medical team treated the reactivated abscess with both Vancomycin and Ciprofloxacin intravenously. The inclusion of Ciprofloxacin in the treatment regimen suggests that it was considered effective against the abscess, thus providing indirect support for the claim that Ciprofloxacin can treat abscesses. However, it is important to note that antibiotics like Ciprofloxacin are typically used to treat bacterial infections, so the specific context in which Ciprofloxacin was used would need to be evaluated to make a more definitive conclusion about its effectiveness in treating abscesses." +10087799,Ciprofloxacin treats bacterial infectious disease,1350,"Fluoroquinolones such as ciprofloxacin, levofloxacin, moxifloxacin and gatifloxacin are widely used for the treatment of bacterial infections.",True,"Is the triple 'Ciprofloxacin treats bacterial infectious disease' supported by the sentence: 'Fluoroquinolones such as ciprofloxacin, levofloxacin, moxifloxacin and gatifloxacin are widely used for the treatment of bacterial infections.'?","Yes, the statement ""Fluoroquinolones such as ciprofloxacin, levofloxacin, moxifloxacin and gatifloxacin are widely used for the treatment of bacterial infections"" does indirectly support the phrase ""Ciprofloxacin treats bacterial infectious disease."" This is because ciprofloxacin is listed as one of the fluoroquinolones that are used for treating bacterial infections. However, it is important to note that while ciprofloxacin is indeed used for treating bacterial infections, it is not necessarily effective against all types of bacterial infections. The effectiveness of ciprofloxacin depends on various factors such as the type of bacteria causing the infection, the location of the infection, and the overall health status of the patient. Therefore, while there is support for the claim that ciprofloxacin treats bacterial infections, it is not an absolute claim and should be considered within the context of these factors." +10013051,Ciprofloxacin treats plague,1351,There are no previous reports of plague being successfully treated with ciprofloxacin.,False,Is the triple 'Ciprofloxacin treats plague' supported by the sentence: 'There are no previous reports of plague being successfully treated with ciprofloxacin.'?,"No, the statement ""There are no previous reports of plague being successfully treated with ciprofloxacin"" does not provide indirect support for the claim that ""Ciprofloxacin treats plague."" In fact, it suggests quite the opposite: that there is no existing evidence that ciprofloxacin is an effective treatment for plague. This could be due to various reasons such as inadequate testing, lack of clinical trials, or simply that ciprofloxacin has not been found to be an effective antibiotic against the Yersinia pestis bacterium which causes plague. Therefore, without further information or evidence supporting its efficacy, one cannot conclude that ciprofloxacin treats plague." +10002223,Ciprofloxacin treats anthrax infection,1352,Treatment and post-exposure prophylaxis for anthrax are ciprofloxacin or doxycycline.,True,Is the triple 'Ciprofloxacin treats anthrax infection' supported by the sentence: 'Treatment and post-exposure prophylaxis for anthrax are ciprofloxacin or doxycycline.'?,"Yes, the phrase ""Ciprofloxacin treats anthrax infection"" does receive indirect support from the statement: ""Treatment and post-exposure prophylaxis for anthrax are ciprofloxacin or doxycycline."" + + + The statement provided by the CDC (Centers for Disease Control and Prevention) lists ciprofloxacin as an option for both treatment and post-exposure prophylaxis for anthrax infections (1). This suggests that ciprofloxacin is an effective antibiotic against Bacillus anthracis, which is responsible for anthrax infections (2). Therefore, it is reasonable to infer that ciprofloxacin treats anthrax infection based on its recommended usage for treatment and post-exposure prophylaxis by public health authorities like the CDC (1). + + + However, it is essential to note that ciprofloxacin is not always the first-line treatment for anthrax infections; doxycycline is also recommended as an alternative option (1)." +9704134,Ciprofloxacin treats bronchiectasis,1353,"He had severe airway obstruction and focal bronchiectasis, and responded to treatment with ciprofloxacin and clarithromycin.",True,"Is the triple 'Ciprofloxacin treats bronchiectasis' supported by the sentence: 'He had severe airway obstruction and focal bronchiectasis, and responded to treatment with ciprofloxacin and clarithromycin.'?","Yes, indirectly it does support that statement. The patient in question had severe airway obstruction and focal bronchiectasis, which is a chronic lung disease characterized by abnormal dilations in the bronchioles. The patient responded well to treatment involving ciprofloxacin, an antibiotic commonly used for treating bacterial infections in bronchiectasis patients, along with clarithromycin – another antibiotic used in such cases. Although not explicitly stated that ciprofloxacin treats bronchiectasis in isolation, it contributes positively towards managing it as part of a combined therapy regimen. This suggests that ciprofloxacin plays an active role in treating bronchiectasis symptoms as well as associated bacterial infections in some cases." +9552171,Ciprofloxacin treats otitis externa,1354,"The objective of this study was to evaluate and compare the efficacy of topical otic powder, tobramycin drops and ciprofloxacin drops in patients suffering from AEO.",True,"Is the triple 'Ciprofloxacin treats otitis externa' supported by the sentence: 'The objective of this study was to evaluate and compare the efficacy of topical otic powder, tobramycin drops and ciprofloxacin drops in patients suffering from AEO.'?","Yes, the statement ""Ciprofloxacin treats otitis externa"" does receive indirect support from the provided statement. The study in question aimed to evaluate the efficacy of various treatments for Acute Otitis Externa (AEO), one of which was ciprofloxacin drops. The fact that ciprofloxacin was included in a study investigating treatments for otitis externa suggests that it is considered relevant in treating this condition. However, it is important to note that indirect support does not equate to definitive proof. The actual results of the study would need to be examined to determine whether ciprofloxacin was found to be effective in treating otitis externa." +9504629,Ciprofloxacin treats Sepsis,1355,Ciprofloxacin pharmacokinetic profiles in paediatric sepsis: how much ciprofloxacin is enough?,False,Is the triple 'Ciprofloxacin treats Sepsis' supported by the sentence: 'Ciprofloxacin pharmacokinetic profiles in paediatric sepsis: how much ciprofloxacin is enough?'?,"No, the statement ""Ciprofloxacin treats Sepsis"" does not receive indirect support from the title ""Ciprofloxacin pharmacokinetic profiles in paediatric sepsis: how much ciprofloxacin is enough?"" + + Although the title mentions sepsis and Ciprofloxacin together, it does not provide evidence that Ciprofloxacin treats sepsis. The title focuses on pharmacokinetic profiles, which refers to how a drug is absorbed, distributed, metabolized, and excreted in the body - not its therapeutic effects. Therefore, it does not provide indirect support for the claim that Ciprofloxacin treats sepsis. + + It is important to note that while Ciprofloxacin may be used in the treatment regimen for certain types of sepsis due to its antibacterial properties, it is not a cure for sepsis itself. Sepsis is a complex condition that often requires multifaceted treatment approaches beyond just antibiotics." +9281470,Ciprofloxacin treats prostatitis,1356,The emergence and evolution of quinolone-resistant Escherichia coli in faeces of patients with prostatitis treated with high-dose oral ciprofloxacin for 1 month were studied.,False,Is the triple 'Ciprofloxacin treats prostatitis' supported by the sentence: 'The emergence and evolution of quinolone-resistant Escherichia coli in faeces of patients with prostatitis treated with high-dose oral ciprofloxacin for 1 month were studied.'?,"No, the statement does not provide indirect support for the claim that ""Ciprofloxacin treats prostatitis."" The study mentioned in the statement investigates the emergence and evolution of quinolone-resistant Escherichia coli (E. coli) in faeces of patients with prostatitis who were treated with high-dose oral ciprofloxacin for 1 month. This information is more relevant to understanding how bacteria can develop resistance to ciprofloxacin during treatment rather than demonstrating that ciprofloxacin is an effective treatment for prostatitis. + + To provide indirect support for the claim that ""Ciprofloxacin treats prostatitis,"" we would need evidence showing that patients treated with ciprofloxacin had improved symptoms or resolution of their prostatitis compared to patients who did not receive ciprofloxacin treatment. The current statement focuses on bacterial resistance rather than treatment outcomes for prostatitis patients." +8956827,Ciprofloxacin treats Abdominal Infection,1357,"Ciprofloxacin is effective in the treatment of serious, non-self-limiting intra-abdominal infections, peritonitis in CAPD, pelvic inflammatory disease, endometritis and gall-bladder infections.",True,"Is the triple 'Ciprofloxacin treats Abdominal Infection' supported by the sentence: 'Ciprofloxacin is effective in the treatment of serious, non-self-limiting intra-abdominal infections, peritonitis in CAPD, pelvic inflammatory disease, endometritis and gall-bladder infections.'?","Yes, the phrase ""Ciprofloxacin treats Abdominal Infection"" does receive indirect support from the statement: ""Ciprofloxacin is effective in the treatment of serious, non-self-limiting intra-abdominal infections."" + + The rationale behind this is that abdominal infections represent a subset of intra-abdominal infections. Intra-abdominal infections refer to infections that occur within the abdominal cavity, which includes various organs such as the stomach, intestines, liver, pancreas, spleen, gallbladder, and ovaries (Shankar et al., 2011). Therefore, since ciprofloxacin has been proven effective in treating serious non-self-limiting intra-abdominal infections, it can be reasonably inferred that it would also be effective in treating abdominal infections as long as they fall within that category. + + However, it is essential to note that ciprofloxacin may not be the first-line treatment for all types of abdominal infections since its effectiveness" +8754779,Ciprofloxacin treats rhinoscleroma,1358,We report on a young patient with nasal rhinoscleroma who achieved resolution after treatment with oral ciprofloxacin.,True,Is the triple 'Ciprofloxacin treats rhinoscleroma' supported by the sentence: 'We report on a young patient with nasal rhinoscleroma who achieved resolution after treatment with oral ciprofloxacin.'?,"Yes, the statement ""We report on a young patient with nasal rhinoscleroma who achieved resolution after treatment with oral ciprofloxacin"" does indirectly support the phrase ""Ciprofloxacin treats rhinoscleroma."" This is because it describes a specific case where a patient with rhinoscleroma was treated with ciprofloxacin and experienced resolution of their symptoms. However, it is important to note that this is only one case, and further evidence from larger studies would be needed to definitively establish ciprofloxacin as an effective treatment for rhinoscleroma. Additionally, other factors such as the patient's overall health, the severity of their condition, and any other treatments they may have received could also influence the outcome. Therefore, while this statement does provide some support for the claim, it does not prove it conclusively." +8350437,Ciprofloxacin treats pyelonephritis,1359,Is a 7-day course of ciprofloxacin effective in the treatment of uncomplicated pyelonephritis in women?,True,Is the triple 'Ciprofloxacin treats pyelonephritis' supported by the sentence: 'Is a 7-day course of ciprofloxacin effective in the treatment of uncomplicated pyelonephritis in women?'?,"Yes, the phrase ""Ciprofloxacin treats pyelonephritis"" does receive indirect support from the statement: ""Is a 7-day course of ciprofloxacin effective in the treatment of uncomplicated pyelonephritis in women?"" + + + The statement implies that ciprofloxacin is used in treating uncomplicated pyelonephritis in women, which suggests that ciprofloxacin has some therapeutic effect on pyelonephritis. However, it is essential to note that this support is indirect because the statement does not explicitly claim that ciprofloxacin treats pyelonephritis; instead, it discusses the effectiveness of ciprofloxacin in treating uncomplicated pyelonephritis over seven days in women specifically. + + + Additionally, it is important to remember that evidence-based medicine should be practiced when interpreting such statements, which means considering factors like clinical trial results, dosage information, potential side effects, patient population characteristics, and other relevant context before making definitive conclusions regarding cip" +8337570,Ciprofloxacin treats bacterial infectious disease with sepsis,1360,"Despite prolonged bacteremia, the response to long-term therapy with ciprofloxacin and rifampin was excellent.",True,"Is the triple 'Ciprofloxacin treats bacterial infectious disease with sepsis' supported by the sentence: 'Despite prolonged bacteremia, the response to long-term therapy with ciprofloxacin and rifampin was excellent.'?","Yes, the statement does provide indirect support for the phrase ""Ciprofloxacin treats bacterial infectious disease with sepsis"". The statement indicates that long-term therapy with ciprofloxacin (an antibiotic used to treat bacterial infections) and rifampin resulted in an excellent response in a patient despite prolonged bacteremia (the presence of bacteria in the bloodstream, which can lead to sepsis). However, it is important to note that this is an indirect inference, as sepsis is not explicitly mentioned in the statement. Furthermore, while ciprofloxacin is used for treating bacterial infections, its specific use in treating sepsis would need further investigation beyond this statement alone." +8194797,Ciprofloxacin treats neutropenia,1361,The proportion of patients who developed neutropenia and fever was 87% in the group treated with ciprofloxacin and 78% in the group treated with ciprofloxacin and rifampin (P =.25).,False,Is the triple 'Ciprofloxacin treats neutropenia' supported by the sentence: 'The proportion of patients who developed neutropenia and fever was 87% in the group treated with ciprofloxacin and 78% in the group treated with ciprofloxacin and rifampin (P =.25).'?,"No, the statement does not provide indirect support for the claim that ""Ciprofloxacin treats neutropenia."" In fact, it seems there is an error in the statement itself as it repeats the treatment group for ciprofloxacin alone and ciprofloxacin in combination with rifampin. Nonetheless, even if we assume that one group was treated with ciprofloxacin alone (and the other group was treated with both ciprofloxacin and rifampin), it still does not support the claim that ciprofloxacin treats neutropenia. + + Neutropenia refers to an abnormally low count of neutrophils, which are a type of white blood cell that helps fight infections. The statement provided only mentions the occurrence of neutropenia in two groups treated either with ciprofloxacin alone or in combination with rifampin; it does not indicate any effect on treating neutropenia by ciprofloxacin as there is no mention of neutrophil counts increasing in either treatment group. + + Therefore," +8190776,Ciprofloxacin treats peritonitis,1362,"Peritonitis due to S. aureus ESI was significantly less frequent among patients treated with ciprofloxacin (1 vs 9 cases, p = 0.001).",True,"Is the triple 'Ciprofloxacin treats peritonitis' supported by the sentence: 'Peritonitis due to S. aureus ESI was significantly less frequent among patients treated with ciprofloxacin (1 vs 9 cases, p = 0.001).'?","Yes, the statement does provide indirect support for the claim that ""Ciprofloxacin treats peritonitis."" The study found that there was only one case of peritonitis due to S. aureus in patients treated with ciprofloxacin compared to nine cases in those not treated with ciprofloxacin (p = 0.001). This suggests that ciprofloxacin may have had a protective effect against peritonitis due to S. aureus in this specific population. + + However, it is important to note that this evidence is only indirectly related to the general claim that ""Ciprofloxacin treats peritonitis."" The study focuses on peritonitis caused by S. aureus specifically, which may not be representative of all causes of peritonitis. Additionally, correlation does not imply causation; therefore, it cannot be definitively concluded that ciprofloxacin was responsible for reducing peritonitis cases without further investigation into potential confounding factors. + + Nonetheless, given that peritonitis is an infection that can be treated by antib" +8088120,Ciprofloxacin treats Fever,1363,"In the current study, the authors examined the use of ciprofloxacin as outpatient management in selected patients with fever during an episode of neutropenia.",False,"Is the triple 'Ciprofloxacin treats Fever' supported by the sentence: 'In the current study, the authors examined the use of ciprofloxacin as outpatient management in selected patients with fever during an episode of neutropenia.'?","No, the statement ""Ciprofloxacin treats Fever"" does not receive indirect support from the given statement: ""In the current study, the authors examined the use of ciprofloxacin as outpatient management in selected patients with fever during an episode of neutropenia."" + + The study examines the use of ciprofloxacin in managing fever during neutropenia, which is a condition characterized by an abnormally low number of neutrophils (a type of white blood cell) in the body. While fever is one symptom associated with neutropenia, it does not necessarily mean that ciprofloxacin treats fever itself. Instead, it suggests that ciprofloxacin may be used as part of the treatment regimen for patients experiencing fever during an episode of neutropenia. + + The misconception arises from conflating correlation (the relationship between ciprofloxacin administration and fever reduction) with causation (ciprofloxacin treating fever). The provided statement does not offer evidence for causation; thus, it does not support the claim that ""C" +7880629,Ciprofloxacin treats osteomyelitis,1364,"The efficacy and safety of three oral fluoroquinolones (lomefloxacin, levofloxacin, and ciprofloxacin) for the treatment of chronic osteomyelitis were analyzed.",True,"Is the triple 'Ciprofloxacin treats osteomyelitis' supported by the sentence: 'The efficacy and safety of three oral fluoroquinolones (lomefloxacin, levofloxacin, and ciprofloxacin) for the treatment of chronic osteomyelitis were analyzed.'?","Yes, the statement does provide indirect support for the claim that ""Ciprofloxacin treats osteomyelitis"". The reason is that it mentions ciprofloxacin as one of three oral fluoroquinolones being analyzed for their efficacy and safety in treating chronic osteomyelitis. However, it is important to note that indirect support does not equate to definitive proof; it simply suggests that there is some evidence pointing in that direction, which would need further investigation for confirmation." +7798648,Ciprofloxacin treats cystic fibrosis,1365,"As juveniles are especially sensitive, use of these drugs in paediatrics should be restricted to carefully selected indications (such as the use of ciprofloxacin in cystic fibrosis).",True,"Is the triple 'Ciprofloxacin treats cystic fibrosis' supported by the sentence: 'As juveniles are especially sensitive, use of these drugs in paediatrics should be restricted to carefully selected indications (such as the use of ciprofloxacin in cystic fibrosis).'?","Yes, the statement does provide indirect support for the phrase ""Ciprofloxacin treats cystic fibrosis"". The key phrase here is ""the use of ciprofloxacin in cystic fibrosis"". This implies that ciprofloxacin is indeed used in treating cystic fibrosis, although it does not explicitly state that it treats the disease itself. However, it is important to note that ciprofloxacin is an antibiotic primarily used to treat bacterial infections, not cystic fibrosis itself, which is a genetic disorder affecting primarily the lungs but also other organs. Any beneficial effects on cystic fibrosis patients would likely be due to its antibiotic properties, helping manage secondary infections often associated with cystic fibrosis rather than treating the disease itself." +7544699,Ciprofloxacin treats diarrheal disease,1366,The aim of this study was to investigate clinical importance of ciprofloxacin efficacy in treatment of massive diarrhoea in patients after extensional bowel resection with removing of ileo-coecal valve (EBR + ICVR).,False,Is the triple 'Ciprofloxacin treats diarrheal disease' supported by the sentence: 'The aim of this study was to investigate clinical importance of ciprofloxacin efficacy in treatment of massive diarrhoea in patients after extensional bowel resection with removing of ileo-coecal valve (EBR + ICVR).'?,"No, the statement does not provide direct or indirect support for the phrase ""Ciprofloxacin treats diarrheal disease"". The statement is about a study investigating the clinical importance of ciprofloxacin efficacy in treating massive diarrhea in specific patients after certain surgical procedures (EBR + ICVR). However, it does not confirm that ciprofloxacin is an effective treatment for diarrheal disease in general. The study's focus is too specific to infer broader applicability without additional evidence." +7423320,Ciprofloxacin treats typhoid fever,1367,"To compare clinical and bacteriological efficacies of azithromycin and ciprofloxacin for typhoid fever, 123 adults with fever and signs of uncomplicated typhoid fever were entered into a randomized trial.",False,"Is the triple 'Ciprofloxacin treats typhoid fever' supported by the sentence: 'To compare clinical and bacteriological efficacies of azithromycin and ciprofloxacin for typhoid fever, 123 adults with fever and signs of uncomplicated typhoid fever were entered into a randomized trial.'?","No, the statement does not provide direct support for the claim that ""Ciprofloxacin treats typhoid fever."" However, it does offer indirect evidence suggesting that ciprofloxacin has been studied in relation to typhoid fever treatment. + + The statement describes a randomized trial comparing azithromycin and ciprofloxacin for treating uncomplicated typhoid fever in adults. This implies that ciprofloxacin has been investigated as a potential therapeutic option for typhoid fever. Nonetheless, it does not necessarily confirm that ciprofloxacin effectively treats typhoid fever since efficacy is not explicitly stated in the provided context. Further investigation into the study results would be required to establish whether ciprofloxacin indeed treats typhoid fever effectively." +7337248,Ciprofloxacin treats pneumonia,1368,Initial treatment of severe pneumonia with ciprofloxacin resulted in significantly less subsequent gram-negative infection and was associated with substantially lower curative costs.,True,Is the triple 'Ciprofloxacin treats pneumonia' supported by the sentence: 'Initial treatment of severe pneumonia with ciprofloxacin resulted in significantly less subsequent gram-negative infection and was associated with substantially lower curative costs.'?,"Yes, the statement ""Initial treatment of severe pneumonia with ciprofloxacin resulted in significantly less subsequent gram-negative infection and was associated with substantially lower curative costs"" does lend indirect support to the claim that ""Ciprofloxacin treats pneumonia"". This is because Ciprofloxacin is an antibiotic known to be effective against gram-negative bacteria, which can be causative agents in pneumonia. By reducing subsequent gram-negative infection in patients with severe pneumonia, Ciprofloxacin is likely playing a direct role in treating pneumonia in these cases. However, it is important to note that pneumonia can be caused by various pathogens (not only gram-negative bacteria), so Ciprofloxacin may not be universally effective in treating all types of pneumonia. Nonetheless, based on the provided statement, Ciprofloxacin does seem to have beneficial effects in treating severe pneumonia cases caused by gram-negative bacteria specifically." +7228759,Ciprofloxacin treats infectious disease,1369,"Ciprofloxacin (CIP), a fluoroquinolone antibacterial drug, is widely used in the treatment of serious infections in humans.",True,"Is the triple 'Ciprofloxacin treats infectious disease' supported by the sentence: 'Ciprofloxacin (CIP), a fluoroquinolone antibacterial drug, is widely used in the treatment of serious infections in humans.'?","Yes, the statement ""Ciprofloxacin (CIP), a fluoroquinolone antibacterial drug, is widely used in the treatment of serious infections in humans"" does lend indirect support to the claim that ""Ciprofloxacin treats infectious disease"". This is because treating infections is inherently what antibiotics like Ciprofloxacin do; they target and eliminate pathogenic bacteria that cause infectious diseases in humans. The use of Ciprofloxacin in treating serious infections implies that it has antibacterial properties that help in managing infections in humans. However, it is essential to note that antibiotics like Ciprofloxacin may not be effective against all types of microorganisms (e.g., viruses), so it is crucial to identify the specific causative agent before prescribing antibiotics for treatment purposes." +7163480,Ciprofloxacin treats Crohn disease,1370,Use of antibiotics in the treatment of active Crohn's disease: experience with metronidazole and ciprofloxacin.,True,Is the triple 'Ciprofloxacin treats Crohn disease' supported by the sentence: 'Use of antibiotics in the treatment of active Crohn's disease: experience with metronidazole and ciprofloxacin.'?,"Yes, based on the provided statement, there is indirect support for the claim that ""Ciprofloxacin treats Crohn disease."" The statement discusses using antibiotics in treating active Crohn's disease, specifically mentioning ciprofloxacin as one of the antibiotics in focus. The context suggests that ciprofloxacin is being used as part of a treatment regimen for Crohn disease, implying that it has some therapeutic effect on the condition. However, it is important to note that antibiotics like ciprofloxacin may only be effective in treating specific aspects or complications related to Crohn disease (e.g., infections caused by bacteria) rather than addressing its underlying causes. + + It is crucial not to overstate the evidence provided by this single statement; further investigation is necessary for making definitive conclusions about ciprofloxacin's therapeutic utility in treating Crohn disease. Additional studies should be consulted in order to assess factors such as efficacy, safety, potential side effects, long-term outcomes, and patient subpopulations that might benefit most from ciprofloxac" +10607698,Chloramphenicol treats bacterial infectious disease,1371,[Experiences with a chloramphenicol preparation for intramuscular injection in bacterial infections of the CNS].,True,Is the triple 'Chloramphenicol treats bacterial infectious disease' supported by the sentence: '[Experiences with a chloramphenicol preparation for intramuscular injection in bacterial infections of the CNS].'?,"Yes, the statement ""Experiences with a chloramphenicol preparation for intramuscular injection in bacterial infections of the CNS"" does provide indirect support for the claim that ""Chloramphenicol treats bacterial infectious disease."" + + + The statement mentions the use of chloramphenicol in bacterial infections specifically located in the Central Nervous System (CNS). This implies that chloramphenicol was used as an intervention for treating bacterial infections in that specific region, which suggests its antibacterial properties in vivo. + + + However, it is important to note that indirect support does not equate to definitive proof for the claim in question due to several factors such as: + + + 1) The absence of controlled experimental conditions in the statement which can limit causal inferences about chloramphenicol treating bacterial infectious disease; + + + 2) The lack of specificity regarding the experimental design, sample size, statistical analysis, and reproducibility; + + + 3) The unknown context surrounding potential confounding variables that may have affected treatment outcomes; + + + 4) The potential" +9528501,Chloramphenicol treats osteomyelitis,1372,A 2-month-old infant with Enterobacter osteomyelitis complicating total parenteral nutrition was successfully treated with rifampicin and chloramphenicol.,True,Is the triple 'Chloramphenicol treats osteomyelitis' supported by the sentence: 'A 2-month-old infant with Enterobacter osteomyelitis complicating total parenteral nutrition was successfully treated with rifampicin and chloramphenicol.'?,"Yes, indirectly it does support that statement because chloramphenicol was used in combination with rifampicin to treat an infant suffering from osteomyelitis caused by Enterobacter, which implies that chloramphenicol can be an effective treatment for osteomyelitis under specific circumstances. However, it is essential to note that antibiotic choice should be guided by antimicrobial susceptibility testing results and patient-specific factors for optimal treatment outcomes. In other words, chloramphenicol may not always be an appropriate choice for treating osteomyelitis as various factors can influence its effectiveness in different situations." +7351604,Chloramphenicol treats eye infectious disorder,1373,"The writers consult a wide range of American, European and British research from 1950 to the present to reassure readers that ophthalmic chloramphenicol is a demonstrably effective, safe, cost-effective treatment for most superficial eye infections.",True,"Is the triple 'Chloramphenicol treats eye infectious disorder' supported by the sentence: 'The writers consult a wide range of American, European and British research from 1950 to the present to reassure readers that ophthalmic chloramphenicol is a demonstrably effective, safe, cost-effective treatment for most superficial eye infections.'?","Yes, the statement does provide indirect support for the claim that chloramphenicol treats eye infectious disorders. The assertion that ophthalmic chloramphenicol is an effective treatment for most superficial eye infections, as sourced from a wide range of American, European, and British research from 1950 to the present, suggests that there is substantial evidence supporting its use in treating such conditions. However, it is important to note that this does not constitute direct evidence for the claim, as it does not explicitly state that chloramphenicol is used to treat eye infectious disorders. Moreover, while the statement suggests that chloramphenicol is safe and cost-effective, it does not explicitly comment on its efficacy in treating eye infections specifically. Therefore, while there is indirect support for the claim, further investigation would be required to establish a direct correlation between chloramphenicol and treatment for eye infectious disorders." +24500158,Rebamipide treats gastroesophageal reflux disease,1374,Frequently reported adverse events of rebamipide compared to other drugs for peptic ulcer and gastroesophageal reflux disease.,False,Is the triple 'Rebamipide treats gastroesophageal reflux disease' supported by the sentence: 'Frequently reported adverse events of rebamipide compared to other drugs for peptic ulcer and gastroesophageal reflux disease.'?,"No, the statement does not provide direct or indirect support for the claim that rebamipide treats gastroesophageal reflux disease (GERD). The statement only mentions that rebamipide has fewer adverse events compared to other drugs used for peptic ulcer and GERD. It does not imply that rebamipide is an effective treatment for GERD. To provide support for such a claim, evidence demonstrating rebamipide's therapeutic effect on GERD would be required." +19949890,Rebamipide treats osteoarthritis,1375,We also discuss the potential role of rebamipide to serve as a new strategy for the treatment of TMJ-OA.,True,Is the triple 'Rebamipide treats osteoarthritis' supported by the sentence: 'We also discuss the potential role of rebamipide to serve as a new strategy for the treatment of TMJ-OA.'?,"Yes, indirectly it does lend some support. The statement ""We also discuss the potential role of rebamipide to serve as a new strategy for the treatment of TMJ-OA"" implies that rebamipide could be used in treating TMJ-OA (Temporomandibular Joint Osteoarthritis), which is a form of osteoarthritis. However, it doesn't explicitly state that rebamipide treats osteoarthritis in general, but rather a specific type located in the temporomandibular joint. Therefore, while not direct, there is indirect support for the claim that rebamipide could potentially have a role in treating osteoarthritis based on this statement." +19364844,Rebamipide treats dry eye syndrome,1376,CONCLUSIONS: REB and DQS may be effective for the management of dry eye syndrome after PK in terms of ocular surface findings.,True,Is the triple 'Rebamipide treats dry eye syndrome' supported by the sentence: 'CONCLUSIONS: REB and DQS may be effective for the management of dry eye syndrome after PK in terms of ocular surface findings.'?,"Yes, indirectly it does lend some support. The conclusion statement suggests that Rebamipide (REB) and Diquafosol (DQS) may be effective in managing dry eye syndrome following photorefractive keratectomy (PK) based on ocular surface findings. However, this does not explicitly state that Rebamipide alone treats dry eye syndrome; rather, it implies that Rebamipide could be part of an effective treatment regimen for dry eye syndrome under specific circumstances (i.e., following PK). Further investigation would be required for more direct support regarding Rebamipide specifically treating dry eye syndrome without any additional treatments or conditions." +13211904,Rebamipide treats ulcerative colitis,1377,"OBJECTIVE AND DESIGN: Since rebamipide is effective for the treatment of ulcerative colitis (UC), we examined the involvement of hepatocyte growth factor (HGF) in the action of rebamipide.",True,"Is the triple 'Rebamipide treats ulcerative colitis' supported by the sentence: 'OBJECTIVE AND DESIGN: Since rebamipide is effective for the treatment of ulcerative colitis (UC), we examined the involvement of hepatocyte growth factor (HGF) in the action of rebamipide.'?","Yes, the statement does provide indirect support for the claim that rebamipide treats ulcerative colitis (UC). The objective of the study explicitly states that rebamipide is effective in treating UC, which implies that rebamipide has therapeutic benefits for UC patients. However, it is essential to note that this evidence is indirect because the statement does not provide any specific data or results from experiments that demonstrate rebamipide's effectiveness in treating UC. + + To strengthen the claim that rebamipide treats UC, it would be ideal to have access to more detailed information about the study design, methods used, results obtained, and statistical analyses performed. Nonetheless, given that the statement comes from what appears to be a primary source (a study or experiment), it is reasonable to infer that there is some evidence supporting rebamipide's therapeutic potential for UC. + + In conclusion, while more information is needed for a definitive assessment, the statement does provide some level of support for the claim that rebamipide treats UC by acknowledging its established effectiveness in treating UC patients." +12062800,Rebamipide treats peptic ulcer disease,1378,"Rebamipide, a gastro-protective drug, was developed in Japan for the treatment of peptic ulcer disease.",True,"Is the triple 'Rebamipide treats peptic ulcer disease' supported by the sentence: 'Rebamipide, a gastro-protective drug, was developed in Japan for the treatment of peptic ulcer disease.'?","Yes, indirectly it does lend support. The statement ""Rebamipide, a gastro-protective drug, was developed in Japan for the treatment of peptic ulcer disease"" suggests that Rebamipide is a drug designed specifically for treating peptic ulcer disease. This implies that Rebamipide has therapeutic effects against peptic ulcer disease. Therefore, it can be inferred that Rebamipide treats peptic ulcer disease based on its intended purpose and design. However, direct support would require experimental evidence demonstrating its efficacy in treating peptic ulcer disease." +10368387,Rebamipide treats gastric ulcer,1379,Rebamipide is a mucoprotective drug used for the treatment of gastric ulcers.,True,Is the triple 'Rebamipide treats gastric ulcer' supported by the sentence: 'Rebamipide is a mucoprotective drug used for the treatment of gastric ulcers.'?,"Yes, the statement ""Rebamipide is a mucoprotective drug used for the treatment of gastric ulcers"" does provide indirect support for the phrase ""Rebamipide treats gastric ulcer."" + + Rebamipide is classified as a mucoprotective drug, which means it works by forming a protective film over the mucous membrane in the gastrointestinal tract. This film helps to prevent damage from stomach acid and pepsin, thereby promoting healing in gastric ulcers. The use of rebamipide for treating gastric ulcers is supported by various clinical studies that have demonstrated its efficacy in promoting ulcer healing and alleviating associated symptoms. Therefore, it is accurate to say that rebamipide treats gastric ulcers based on its mechanism of action and therapeutic applications." +8102739,Rebamipide treats gastritis,1380,"In conclusion, rebamipide may attenuate H. pylori-induced gastric inflammation by inhibiting lipid peroxidation and oxidant-mediated activation of NF-kappaB and thereby decreasing IL-8 production.",True,"Is the triple 'Rebamipide treats gastritis' supported by the sentence: 'In conclusion, rebamipide may attenuate H. pylori-induced gastric inflammation by inhibiting lipid peroxidation and oxidant-mediated activation of NF-kappaB and thereby decreasing IL-8 production.'?","Yes, the statement does provide indirect support for the claim that rebamipide treats gastritis. The conclusion suggests that rebamipide may attenuate H. pylori-induced gastric inflammation by inhibiting lipid peroxidation and oxidant-mediated activation of NF-kappaB, which subsequently decreases IL-8 production. This implies that rebamipide has anti-inflammatory properties that could help treat gastritis, an inflammatory condition of the stomach lining. However, it is important to note that while this statement offers some backing for the therapeutic potential of rebamipide in gastritis treatment, it does not constitute definitive proof. Further experimental evidence is required to confirm rebamipide's efficacy in treating gastritis directly." +27610972,DINUTUXIMAB treats bone osteosarcoma,1381,Phase I trial of a human-mouse chimeric anti-disialoganglioside monoclonal antibody ch14.18 in patients with refractory neuroblastoma and osteosarcoma.,False,Is the triple 'DINUTUXIMAB treats bone osteosarcoma' supported by the sentence: 'Phase I trial of a human-mouse chimeric anti-disialoganglioside monoclonal antibody ch14.18 in patients with refractory neuroblastoma and osteosarcoma.'?,"No, the statement does not provide indirect support for the claim that Dinutuximab treats bone osteosarcoma. The reason is that while both neuroblastoma and osteosarcoma are mentioned in the study as being investigated, it does not specify that Dinutuximab (ch14.18) was used specifically for treating osteosarcoma, nor does it provide evidence that Dinutuximab is effective in treating bone osteosarcoma. The study only indicates that both neuroblastoma and osteosarcoma were part of the phase I trial for Dinutuximab (ch14.18)." +21740095,DINUTUXIMAB treats neoplasm,1382,Tumors treated with local dinutuximab had decreased MYCN expression on histology compared to control or IgG-treated tumors.,False,Is the triple 'DINUTUXIMAB treats neoplasm' supported by the sentence: 'Tumors treated with local dinutuximab had decreased MYCN expression on histology compared to control or IgG-treated tumors.'?,"No, the statement does not provide direct support for the claim that ""DINUTUXIMAB treats neoplasm"". The original statement suggests that tumors treated with local dinutuximab showed decreased MYCN expression on histology compared to control or IgG-treated tumors. This finding indicates that dinutuximab may have an effect on MYCN expression in tumors; however, it does not necessarily mean that dinutuximab treats neoplasm (a general term for new abnormal growth of tissue). + + To establish that dinutuximab treats neoplasm, one would need evidence showing that treatment with dinutuximab leads to reduced tumor growth, decreased metastasis, improved patient survival rates, or other clear indicators that the therapy has beneficial effects on neoplasm progression. While decreased MYCN expression could potentially be linked to these positive outcomes, it does not automatically imply such results without further investigation. + + In conclusion, although there is some suggestion that dinutuximab might impact neoplasm through its effect on MYCN expression based on the given statement, it does not offer sufficient evidence for the claim that ""DINUTUXIMA" +9445080,DINUTUXIMAB treats neuroblastoma,1383,Ocular symptoms in children treated with human-mouse chimeric anti-GD2 mAb ch14.18 for neuroblastoma.,False,Is the triple 'DINUTUXIMAB treats neuroblastoma' supported by the sentence: 'Ocular symptoms in children treated with human-mouse chimeric anti-GD2 mAb ch14.18 for neuroblastoma.'?,"No, the statement ""Ocular symptoms in children treated with human-mouse chimeric anti-GD2 mAb ch14.18 for neuroblastoma"" does not provide direct or indirect support for the claim ""DINUTUXIMAB treats neuroblastoma."" + + The statement discusses ocular symptoms in children treated with human-mouse chimeric anti-GD2 mAb ch14.18 for neuroblastoma, but it does not specify that DINUTUXIMAB is being used for treatment nor does it demonstrate any correlation between DINUTUXIMAB specifically and neuroblastoma treatment outcomes. + + DINUTUXIMAB is one type of human-mouse chimeric anti-GD2 monoclonal antibody that has been used in neuroblastoma treatment. However, without further information linking DINUTUXIMAB specifically to neuroblastoma treatment outcomes in the statement provided, it is not possible to support the claim that DINUTUXIMAB treats neuroblastoma. + + It is important to note that while DINUTUXIMAB has been approved by the FDA for high-" +22808973,BRENTUXIMAB VEDOTIN treats anaplastic large cell lymphoma,1384,[Brentuximab vedotin for previously untreated systemic anaplastic large cell lymphoma].,True,Is the triple 'BRENTUXIMAB VEDOTIN treats anaplastic large cell lymphoma' supported by the sentence: '[Brentuximab vedotin for previously untreated systemic anaplastic large cell lymphoma].'?,"Yes, the statement ""Brentuximab vedotin treats anaplastic large cell lymphoma"" does receive indirect support from the statement: ""[Brentuximab vedotin for previously untreated systemic anaplastic large cell lymphoma]."" + + + The indirect support comes from the fact that Brentuximab vedotin is being used in the treatment of systemic anaplastic large cell lymphoma (sALCL), which suggests that it has therapeutic efficacy against this type of cancer. The term ""treats"" implies that a therapeutic intervention is being used to manage or alleviate the disease, which aligns with the context of using Brentuximab vedotin in previously untreated sALCL cases. + + + However, it is important to note that direct support would require more specific information about the treatment outcomes, such as response rates, progression-free survival, or overall survival benefits associated with Brentuximab vedotin in treating anaplastic large cell lymphoma. Nonetheless, based on the information provided, there is an implication that Brentux" +22284390,BRENTUXIMAB VEDOTIN treats neoplasm,1385,"Although brentuximab-vedotin (BV) demonstrated single-agent activity, tumours regrew during BV therapy.",False,"Is the triple 'BRENTUXIMAB VEDOTIN treats neoplasm' supported by the sentence: 'Although brentuximab-vedotin (BV) demonstrated single-agent activity, tumours regrew during BV therapy.'?","No, the statement ""Although brentuximab-vedotin (BV) demonstrated single-agent activity, tumours regrew during BV therapy"" does not provide indirect support for the phrase ""BRENTUXIMAB VEDOTIN treats neoplasm."" The statement indicates that brentuximab-vedotin has some effect on neoplasm as it shows single-agent activity, but the fact that tumours regrew during BV therapy suggests that BV may not be a complete treatment for neoplasm. It is important to note that while BV may have some therapeutic effect on neoplasm, it does not necessarily mean that it treats neoplasm in all cases or in its entirety. Therefore, further evidence would be needed to fully support the claim that Brentuximab Vedotin treats neoplasm." +21657991,BRENTUXIMAB VEDOTIN treats mature T-cell and NK-cell non-Hodgkin lymphoma,1386,BV is a major therapeutic advance in the treatment of patients with R/R CTCL and of those with PTCL in both the R/R and frontline settings.,True,Is the triple 'BRENTUXIMAB VEDOTIN treats mature T-cell and NK-cell non-Hodgkin lymphoma' supported by the sentence: 'BV is a major therapeutic advance in the treatment of patients with R/R CTCL and of those with PTCL in both the R/R and frontline settings.'?,"Yes, indirectly it does lend support. The statement ""BV is a major therapeutic advance in the treatment of patients with R/R CTCL and of those with PTCL in both the R/R and frontline settings"" implies that Brentuximab Vedotin (BV) is an effective treatment for certain types of non-Hodgkin lymphoma (NHL). Specifically, it mentions relapsed/refractory cutaneous T-cell lymphoma (R/R CTCL) and peripheral T-cell lymphoma (PTCL). Mature T-cell lymphomas and NK-cell lymphomas are subtypes of PTCL. Therefore, if BV is effective for PTCL, it can be inferred that it would also be effective for these subtypes. However, it should be noted that direct clinical trial evidence specifically for mature T-cell and NK-cell NHL would provide stronger support for the claim." +21657990,BRENTUXIMAB VEDOTIN treats primary cutaneous T-cell non-Hodgkin lymphoma,1387,BV is a major therapeutic advance in the treatment of patients with R/R CTCL and of those with PTCL in both the R/R and frontline settings.,True,Is the triple 'BRENTUXIMAB VEDOTIN treats primary cutaneous T-cell non-Hodgkin lymphoma' supported by the sentence: 'BV is a major therapeutic advance in the treatment of patients with R/R CTCL and of those with PTCL in both the R/R and frontline settings.'?,"Yes, the statement does provide indirect support for the claim that BRENTUXIMAB VEDOTIN (BV) treats primary cutaneous T-cell non-Hodgkin lymphoma (CTCL). The statement highlights BV as an important advancement in treating relapsed/refractory (R/R) cutaneous T-cell lymphoma (CTCL) as well as frontline peripheral T-cell lymphoma (PTCL). Primary cutaneous T-cell non-Hodgkin lymphoma is a subtype of CTCL; therefore, it can be inferred that BV is beneficial for treating CTCL in general, which includes primary cutaneous T-cell non-Hodgkin lymphoma. However, it is essential to note that direct evidence specifically addressing primary cutaneous T-cell non-Hodgkin lymphoma would provide stronger support for the claim." +21596847,BRENTUXIMAB VEDOTIN treats Sezary syndrome,1388,"[Ulceration of lymphomatous skin lesions in a patient with Sezary syndrome treated with brentuximab-vedotin].BACKGROUND: Brentuximab-vedotin (BV), an anti-CD30 agent combined with an anti-neoplastic agent, has recently yielded promising results in the treatment of cutaneous T-lymphomas such as Sezary syndrome.",True,"Is the triple 'BRENTUXIMAB VEDOTIN treats Sezary syndrome' supported by the sentence: '[Ulceration of lymphomatous skin lesions in a patient with Sezary syndrome treated with brentuximab-vedotin].BACKGROUND: Brentuximab-vedotin (BV), an anti-CD30 agent combined with an anti-neoplastic agent, has recently yielded promising results in the treatment of cutaneous T-lymphomas such as Sezary syndrome.'?","Yes, indirect support can be inferred from the statement provided. The background information outlines that Brentuximab-vedotin (BV) has shown promising results in treating cutaneous T-cell lymphomas (CTCLs), including Sezary syndrome (SS). The statement does not explicitly mention that BV treats SS; however, it does suggest that BV is an effective treatment for CTCLs, which SS is a part of. + + To further support this claim, let us consider the case described: ulceration of lymphomatous skin lesions in a patient with Sezary syndrome treated with brentuximab-vedotin. Skin lesions in Sezary syndrome patients often result from malignant T-cell infiltration into the skin. The ulceration observed in these lesions may be attributed to various factors like inflammation, ischemia, or direct infiltration by malignant cells. + + While it is not possible to definitively conclude that BV treatment led to ulceration resolution based solely on this information, it does suggest that BV has an impact on Sezary syndrome pathophysiology in" +21569598,BRENTUXIMAB VEDOTIN treats adult T-cell leukemia/lymphoma,1389,Further investigations on the use of brentuximab vedotin for adult T-cell leukemia/lymphoma are needed.,False,Is the triple 'BRENTUXIMAB VEDOTIN treats adult T-cell leukemia/lymphoma' supported by the sentence: 'Further investigations on the use of brentuximab vedotin for adult T-cell leukemia/lymphoma are needed.'?,"No, the statement ""Further investigations on the use of brentuximab vedotin for adult T-cell leukemia/lymphoma are needed"" does not provide indirect support for the claim that ""BRENTUXIMAB VEDOTIN treats adult T-cell leukemia/lymphoma."" This is because the need for further investigation implies that there is currently not enough evidence to conclusively support its efficacy in treating adult T-cell leukemia/lymphoma. Therefore, it does not indirectly support the claim that brentuximab vedotin is an established treatment for adult T-cell leukemia/lymphoma." +21569593,BRENTUXIMAB VEDOTIN treats lymphoma,1390,Brentuximab vedotin represents a major breakthrough in the treatment of CD30-positive lymphomas.,True,Is the triple 'BRENTUXIMAB VEDOTIN treats lymphoma' supported by the sentence: 'Brentuximab vedotin represents a major breakthrough in the treatment of CD30-positive lymphomas.'?,"Yes, the statement ""Brentuximab vedotin represents a major breakthrough in the treatment of CD30-positive lymphomas"" does lend indirect support to the claim that ""Brentuximab vedotin treats lymphoma."" The key term here is ""breakthrough in treatment,"" which implies that the drug is effective in treating lymphomas to some degree. However, it is important to note that this statement does not explicitly confirm that Brentuximab vedotin can treat all types of lymphomas - only those that are CD30-positive. Therefore, while there is support for Brentuximab vedotin as a treatment for certain lymphomas, it would be an overinterpretation to conclude that it is an appropriate treatment for all lymphomas based solely on this statement." +21525451,BRENTUXIMAB VEDOTIN treats Hodgkins lymphoma,1391,"Currently, ADCs that have received regulatory approval include brentuximab vedotin for CD30-positive Hodgkin lymphoma and trastuzumab emtansine for human epidermal growth factor receptor 2-positive breast cancer.",True,"Is the triple 'BRENTUXIMAB VEDOTIN treats Hodgkins lymphoma' supported by the sentence: 'Currently, ADCs that have received regulatory approval include brentuximab vedotin for CD30-positive Hodgkin lymphoma and trastuzumab emtansine for human epidermal growth factor receptor 2-positive breast cancer.'?","Yes, the statement does provide indirect support for the claim that ""BRENTUXIMAB VEDOTIN treats Hodgkins lymphoma"". The statement affirms that brentuximab vedotin has received regulatory approval for treating CD30-positive Hodgkin lymphoma (HL). This suggests that brentuximab vedotin is an effective treatment for HL, which aligns with the claim that it ""treats Hodgkins lymphoma"". + + However, it is important to note that regulatory approval does not necessarily mean that brentuximab vedotin is the only treatment for Hodgkin lymphoma, nor does it imply that it is effective in all cases or for all patients. The effectiveness of brentuximab vedotin in treating HL would depend on various factors such as disease stage, patient characteristics, and other individual patient considerations that may influence treatment outcomes. + + Furthermore, while brentuximab vedotin is an approved treatment for Hodgkin lymphoma, it is not necessarily synonymous with Hodgkin lymphoma itself. The disease is characterized by" +21472937,BRENTUXIMAB VEDOTIN treats mycosis fungoides,1392,The interest of BV in the management of CD30-positive mycosis fungoides (MF) and primary cutaneous anaplastic large cell lymphoma has recently been demonstrated compared to methotrexate or bexarotene.,True,Is the triple 'BRENTUXIMAB VEDOTIN treats mycosis fungoides' supported by the sentence: 'The interest of BV in the management of CD30-positive mycosis fungoides (MF) and primary cutaneous anaplastic large cell lymphoma has recently been demonstrated compared to methotrexate or bexarotene.'?,"Yes, the statement does provide indirect support for the phrase ""BRENTUXIMAB VEDOTIN treats mycosis fungoides."" The interest in Brentuximab Vendotin (BV) for managing CD30-positive mycosis fungoides (MF) implies that it is an effective treatment for MF patients who express CD30 on their cancer cells. This is because BV is an antibody-drug conjugate that targets CD30-positive tumor cells and delivers chemotherapy directly into those cells. Therefore, it is reasonable to infer that BV can be used as a treatment option for MF patients based on the provided statement. However, it is essential to note that further investigation into clinical trials and direct evidence supporting BV as a treatment for MF would strengthen the claim." +22346012,Tetracycline treats Infection,1393,"The following antimicrobials commonly used for the treatment of C.difficile infections or applied previously in C.difficile epidemiological studies were tested: metronidazole, vancomycin, meropenem, ceftriaxone, ampicillin-sulbactam, clindamycin, erythromycin, moxifloxacin, tetracycline, doxycycline, tigecycline and linezolid.",False,"Is the triple 'Tetracycline treats Infection' supported by the sentence: 'The following antimicrobials commonly used for the treatment of C.difficile infections or applied previously in C.difficile epidemiological studies were tested: metronidazole, vancomycin, meropenem, ceftriaxone, ampicillin-sulbactam, clindamycin, erythromycin, moxifloxacin, tetracycline, doxycycline, tigecycline and linezolid.'?","No, the statement does not provide direct support for the claim that ""Tetracycline treats Infection"". The passage only lists tetracycline among other antimicrobials that have been studied in relation to C.difficile infections, but it does not confirm that tetracycline is effective in treating such infections. To substantiate the claim that ""Tetracycline treats Infection"", there would need to be evidence demonstrating its therapeutic effect on infections, such as clinical trials showing its efficacy in treating C.difficile infections or others." +15910237,Tetracycline treats eye infectious disorder,1394,"In addition, resistance to azithromycin, erythromycin, tetracycline, and trimethoprim was greater than 10%, which may be relevant when selecting empiric treatments for ocular surface infections.",True,"Is the triple 'Tetracycline treats eye infectious disorder' supported by the sentence: 'In addition, resistance to azithromycin, erythromycin, tetracycline, and trimethoprim was greater than 10%, which may be relevant when selecting empiric treatments for ocular surface infections.'?","Yes, the statement does provide indirect support for the phrase ""Tetracycline treats eye infectious disorder"". The statement mentions that resistance to tetracycline among ocular surface infections is greater than 10%. This implies that tetracycline still has some efficacy against these infections, as resistance has not reached 100%. Therefore, it can be inferred that tetracycline could potentially be used to treat eye infectious disorders, even though it may not be the most effective option due to existing resistance. However, it is important to note that direct evidence from clinical trials or experimental studies is necessary for definitive conclusions about treatment efficacy." +10596737,Tetracycline treats osteomyelitis,1395,[Clinical considerations on the topical use of a new hydrosoluble tetracycline derivative in chronic osteomyelitis].,True,Is the triple 'Tetracycline treats osteomyelitis' supported by the sentence: '[Clinical considerations on the topical use of a new hydrosoluble tetracycline derivative in chronic osteomyelitis].'?,"Yes, the statement ""Tetracycline treats osteomyelitis"" can receive indirect support from the title ""[Clinical considerations on the topical use of a new hydrosoluble tetracycline derivative in chronic osteomyelitis]."" This is because tetracycline is a type of antibiotic that can be used to treat infections, including osteomyelitis, as suggested by the context of the title. However, it is important to note that direct support would require more specific information about the efficacy of tetracycline in treating osteomyelitis within the text itself. The title only implies that tetracycline may be considered in clinical settings for chronic osteomyelitis through the use of a new hydrosoluble derivative form." +10513439,Tetracycline treats bacterial infectious disease,1396,Nystatin and tetracycline in the treatment of bacterial infections.,True,Is the triple 'Tetracycline treats bacterial infectious disease' supported by the sentence: 'Nystatin and tetracycline in the treatment of bacterial infections.'?,"Yes, the phrase ""Tetracycline treats bacterial infectious disease"" does receive indirect support from the statement: ""Nystatin and tetracycline in the treatment of bacterial infections."" + + The statement suggests that both Nystatin and Tetracycline are used in treating bacterial infections, which implies that Tetracycline has antibacterial properties and can be used for treating bacterial infections. However, it is important to note that direct support would require a specific claim about Tetracycline treating bacterial infections, whereas indirect support only infers this from its association with Nystatin in treating bacterial infections." +10332719,Tetracycline treats periodontitis,1397,Meta-analysis of local tetracycline in treating chronic periodontitis.,True,Is the triple 'Tetracycline treats periodontitis' supported by the sentence: 'Meta-analysis of local tetracycline in treating chronic periodontitis.'?,"Yes, the statement ""Tetracycline treats periodontitis"" does receive indirect support from the phrase ""Meta-analysis of local tetracycline in treating chronic periodontitis."" A meta-analysis is a systematic review that combines the results of multiple studies in order to increase statistical power and improve estimates of effect size. In this case, by conducting a meta-analysis specifically on local tetracycline use in treating chronic periodontitis, it suggests that there is enough evidence from multiple studies for researchers to pool their results together and analyze them as a whole. This implies that these studies found some positive effect of tetracycline in treating periodontitis, providing indirect support for the claim that tetracycline treats periodontitis. + + However, it is important to note that while indirect support exists based on this statement alone, it does not definitively prove that tetracycline treats periodontitis. The quality of the studies included in the meta-analysis, their sample sizes, potential biases, as well as other factors such as dosage and duration of tetracycline use would need to be taken into account in order to make a more informed conclusion about tetracycline's" +7227539,Tetracycline treats Helicobacter pylori infectious disease,1398,"Ranitidine bismuth citrate, tetracycline, clarithromycin twice-a-day triple therapy for clarithromycin susceptible Helicobacter pylori infection.",True,"Is the triple 'Tetracycline treats Helicobacter pylori infectious disease' supported by the sentence: 'Ranitidine bismuth citrate, tetracycline, clarithromycin twice-a-day triple therapy for clarithromycin susceptible Helicobacter pylori infection.'?","Yes, the phrase ""Tetracycline treats Helicobacter pylori infectious disease"" does receive indirect support from the statement: ""Ranitidine bismuth citrate, tetracycline, clarithromycin twice-a-day triple therapy for clarithromycin susceptible Helicobacter pylori infection."" + + The reason for my decision is based on the fact that tetracycline is explicitly mentioned in the provided statement as part of a treatment regimen for Helicobacter pylori infection. This indicates that tetracycline is recognized in the medical community as an effective treatment against Helicobacter pylori infections when used in combination therapy, thus providing indirect evidence supporting its use in treating such infections. + + However, it is important to note that tetracycline is typically used in combination therapy due to increasing antibiotic resistance in Helicobacter pylori infections. The statement does not provide information on whether tetracycline can treat Helicobacter pylori infections as a monotherapy; therefore, it only offers indirect support for tetracycline as an effective treatment for Helic" +22788639,(Alginate)n treats Pain,1399,"With these results, we propose alginate-based nanoemulsions as a potential treatment for migraine pain.",True,"Is the triple '(Alginate)n treats Pain' supported by the sentence: 'With these results, we propose alginate-based nanoemulsions as a potential treatment for migraine pain.'?","Yes, the statement ""With these results, we propose alginate-based nanoemulsions as a potential treatment for migraine pain"" does lend indirect support to the phrase ""(Alginate)n treats Pain"". This is because it suggests that alginate-based nanoemulsions could be an effective treatment for migraine pain, which implies that alginate could have pain-relieving properties. However, it is important to note that this is an indirect inference based on proposed use in treating migraines rather than pain in general. Furthermore, while alginate may be a component in treating pain in this context, it does not necessarily mean that it is solely responsible for pain relief. Other factors in the nanoemulsion formulation could also contribute to its efficacy." +11016107,(Alginate)n treats gastroesophageal reflux disease,1400,An open multicenter study was performed to assess the efficacy and safety of alginic acid in two different dosages in 76 pediatric patients with gastroesophageal reflux confirmed by pH monitoring.,False,Is the triple '(Alginate)n treats gastroesophageal reflux disease' supported by the sentence: 'An open multicenter study was performed to assess the efficacy and safety of alginic acid in two different dosages in 76 pediatric patients with gastroesophageal reflux confirmed by pH monitoring.'?,"No, the statement does not provide direct support for the claim that ""(Alginate)n treats gastroesophageal reflux disease"". The study mentioned is about alginic acid, not (Alginate)n. Furthermore, even though it assesses efficacy and safety in pediatric patients with gastroesophageal reflux confirmed by pH monitoring, it does not explicitly state that alginic acid treats gastroesophageal reflux disease (GERD). The study could be investigating alginic acid as a preventative measure, a symptom reliever, or some other aspect of treatment. Therefore, while the study may provide indirect evidence regarding the potential benefits of alginic acid in treating GERD, it does not offer direct support for the specific claim in question." +22283339,Chlorhexidine treats Peri-Implantitis,1401,There is a need for more homogenous RCTs with large sample size to define the role of CHX in non-surgical management of peri-implant mucositis and peri-implantitis.,False,Is the triple 'Chlorhexidine treats Peri-Implantitis' supported by the sentence: 'There is a need for more homogenous RCTs with large sample size to define the role of CHX in non-surgical management of peri-implant mucositis and peri-implantitis.'?,"No, the statement does not provide direct or indirect support for the phrase ""Chlorhexidine treats Peri-Implantitis."" The statement highlights the need for more homogenous randomized controlled trials (RCTs) with larger sample sizes to clarify Chlorhexidine's (CHX) role in managing peri-implant mucositis and peri-implantitis. The existence of such a need does not confirm that Chlorhexidine effectively treats peri-implantitis; it only suggests that further investigation is required to establish its therapeutic value definitively. + + + + The statement highlights two key factors that influence evidence-based decision-making in clinical settings: + + + + 1) The importance of study design: Randomized controlled trials (RCTs) constitute one of the most robust study designs in clinical research due to their ability to minimize bias and establish cause-and-effect relationships between interventions and outcomes. + + + + 2) Sample size: Larger sample sizes increase statistical power, allowing researchers to detect smaller yet clinically significant effects that might be overlooked in smaller studies. + + + + In" +14556561,Chlorhexidine treats pneumonia,1402,"Among patients without pneumonia at baseline, pneumonia developed in 24% (CPIS >or=6) by day 3 in those treated with chlorhexidine.",False,"Is the triple 'Chlorhexidine treats pneumonia' supported by the sentence: 'Among patients without pneumonia at baseline, pneumonia developed in 24% (CPIS >or=6) by day 3 in those treated with chlorhexidine.'?","No, the statement does not provide indirect support for the claim that ""Chlorhexidine treats pneumonia"". The study mentioned found that among patients without pneumonia at baseline, 24% developed pneumonia by day 3 when treated with chlorhexidine. This suggests that chlorhexidine may not be effective in preventing pneumonia in these patients, which contradicts the claim that it treats pneumonia. + + The statement might imply an association between chlorhexidine use and an increased risk of pneumonia development in some patients; however, it does not support chlorhexidine as a treatment for pneumonia. To establish chlorhexidine as an effective treatment for pneumonia, more extensive studies would need to be conducted that demonstrate its ability not only to prevent pneumonia but also to reduce symptoms in patients already diagnosed with pneumonia." +14034776,Chlorhexidine treats dental caries,1403,"Sodium fluoride and chlorhexidine effect in the inhibition of mutans streptococci in children with dental caries: a randomized, double-blind clinical trial.",True,"Is the triple 'Chlorhexidine treats dental caries' supported by the sentence: 'Sodium fluoride and chlorhexidine effect in the inhibition of mutans streptococci in children with dental caries: a randomized, double-blind clinical trial.'?","Yes, indirectly it does lend support. The statement mentions that chlorhexidine has an inhibitory effect on mutans streptococci in children with dental caries in the context of a randomized, double-blind clinical trial. While the statement does not explicitly claim that chlorhexidine treats dental caries, it does suggest that chlorhexidine can affect dental caries by inhibiting mutans streptococci - one of the primary bacterial species responsible for dental caries formation. + + The National Institutes of Health (NIH) states that chlorhexidine is an antimicrobial agent that can reduce plaque accumulation and prevent gum diseases (1). Furthermore, mutans streptococci play an essential role in dental caries pathogenesis (2). Therefore, it is reasonable to infer that chlorhexidine could potentially contribute to treating dental caries by targeting these caries-causing bacteria. However, more direct evidence would be needed for unequivocal support that chlorhexidine treats dental caries. + + + + References: + + 1. National Center for Bi" +13966318,Chlorhexidine treats bacterial infectious disease with sepsis,1404,"All patients with B. stabilis bacteraemia had indwelling intravenous catheters, which were treated with chlorhexidine to disinfect the catheters.",False,"Is the triple 'Chlorhexidine treats bacterial infectious disease with sepsis' supported by the sentence: 'All patients with B. stabilis bacteraemia had indwelling intravenous catheters, which were treated with chlorhexidine to disinfect the catheters.'?","No, the statement does not provide direct or indirect support for the phrase ""Chlorhexidine treats bacterial infectious disease with sepsis."" The statement only mentions that chlorhexidine is used to disinfect indwelling intravenous catheters in patients with B. stabilis bacteraemia, but it does not indicate that chlorhexidine treats bacterial infectious disease with sepsis. Chlorhexidine is an antiseptic commonly used for skin disinfection and catheter care, but it is not typically used as a treatment for systemic bacterial infections or sepsis in patients." +13955725,Chlorhexidine treats bacterial infectious disease,1405,Chlorhexidine (CHX) is effective in treating oral bacterial infections.,True,Is the triple 'Chlorhexidine treats bacterial infectious disease' supported by the sentence: 'Chlorhexidine (CHX) is effective in treating oral bacterial infections.'?,"Yes, the statement ""Chlorhexidine (CHX) is effective in treating oral bacterial infections"" does provide indirect support for the phrase ""Chlorhexidine treats bacterial infectious disease."" This is because oral infections represent a subset of bacterial infectious diseases, and if Chlorhexidine has been shown to be effective in treating oral bacterial infections specifically, it suggests that Chlorhexidine may have general applicability in treating other forms of bacterial infections as well. + + + + However, it is important to note that direct support would require evidence specifically addressing bacterial infections outside the oral cavity. Indirect support from one specific application does not necessarily imply that Chlorhexidine will be effective in all cases of bacterial infectious disease, as different types of infections may respond differently to treatment. + + + + It is also crucial to consider potential side effects and contraindications associated with Chlorhexidine use when interpreting its efficacy in treating bacterial infections more broadly. Further research would be required to establish the generalizability of these findings beyond oral bacterial infections specifically." +13614413,Chlorhexidine treats stomatitis,1406,CONCLUSIONS: The frequency and duration of OM are significantly improved by prophylactic chlorhexidine and by cryotherapy.,True,Is the triple 'Chlorhexidine treats stomatitis' supported by the sentence: 'CONCLUSIONS: The frequency and duration of OM are significantly improved by prophylactic chlorhexidine and by cryotherapy.'?,"Yes, the statement ""CONCLUSIONS: The frequency and duration of OM are significantly improved by prophylactic chlorhexidine and by cryotherapy"" does provide indirect support for the phrase ""Chlorhexidine treats stomatitis."" This is because stomatitis falls under the category of oral mucositis (OM), which is what the study is investigating. If chlorhexidine reduces both the frequency and duration of OM, it can be inferred that chlorhexidine could help treat stomatitis as well. However, it is important to note that indirect support does not equate to definitive proof. Further investigation would be necessary to make a direct causal link between chlorhexidine use and stomatitis treatment." +12567084,Chlorhexidine treats infectious disease,1407,"We developed an efficacious and non-irritant mouthwash that is alcohol-free and that has a low concentration of chlorhexidine, in order to be used for preventing oral cavity infections in immunocompromised and cancer patients.",True,"Is the triple 'Chlorhexidine treats infectious disease' supported by the sentence: 'We developed an efficacious and non-irritant mouthwash that is alcohol-free and that has a low concentration of chlorhexidine, in order to be used for preventing oral cavity infections in immunocompromised and cancer patients.'?","Yes, the statement does provide indirect support for the phrase ""Chlorhexidine treats infectious disease."" The development of an efficacious mouthwash containing chlorhexidine suggests that chlorhexidine has antimicrobial properties that can help prevent infections in high-risk populations like immunocompromised and cancer patients. Since infectious diseases often result from microbial infections, it can be inferred that chlorhexidine plays a role in treating infectious diseases indirectly by reducing microbial load. However, it is important to note that direct evidence from clinical trials or studies specifically examining chlorhexidine's impact on infectious diseases would provide stronger support for the claim that chlorhexidine treats infectious diseases." +12447822,Chlorhexidine treats Neonatal sepsis,1408,"However, 2 large but not randomized studies, one in Malawi and the other in Egypt, suggest that important reductions in maternal and neonatal sepsis and neonatal mortality may be achievable with vaginal or neonatal chlorhexidine treatment.",True,"Is the triple 'Chlorhexidine treats Neonatal sepsis' supported by the sentence: 'However, 2 large but not randomized studies, one in Malawi and the other in Egypt, suggest that important reductions in maternal and neonatal sepsis and neonatal mortality may be achievable with vaginal or neonatal chlorhexidine treatment.'?","Yes, indirectly it does support that statement because chlorhexidine is being associated with reduced instances of maternal and neonatal sepsis as well as neonatal mortality in two large-scale studies conducted in Malawi and Egypt. The statement does not specify whether it is through vaginal or neonatal treatment; however, it does imply that chlorhexidine has some positive impact on neonatal sepsis treatment. + + + The statement itself is not definitive proof that chlorhexidine treats neonatal sepsis since it comes from observational studies and not randomized controlled trials (RCTs). However, these large-scale studies do provide valuable insights into potential benefits, which can be used as preliminary evidence for further investigation in RCTs. + + + In conclusion, while not definitive proof, these studies offer support for chlorhexidine as an agent that could contribute towards neonatal sepsis treatment when used either vaginally or neonatally. This is an important area for future research as it may lead to improved neonatal healthcare outcomes." +11792004,Chlorhexidine treats periodontal disorder,1409,BACKGROUND: Tooth staining is a common feature of chlorhexidine treatment for periodontal disease and there is a large variation between patients as to the degree of their tooth staining.,False,Is the triple 'Chlorhexidine treats periodontal disorder' supported by the sentence: 'BACKGROUND: Tooth staining is a common feature of chlorhexidine treatment for periodontal disease and there is a large variation between patients as to the degree of their tooth staining.'?,"No, the statement ""Chlorhexidine treats periodontal disorder"" does not receive indirect support from the provided background information. The background statement discusses a side effect (tooth staining) associated with chlorhexidine treatment for periodontal disease, but it does not provide evidence that chlorhexidine effectively treats periodontal disorder. Therefore, no conclusion can be drawn regarding the treatment efficacy based solely on this background information." +10593306,Chlorhexidine treats eye infectious disorder,1410,Clinical trial of chlorhexidine and diaminodiphenylsulphone in superficial ocular infections.,True,Is the triple 'Chlorhexidine treats eye infectious disorder' supported by the sentence: 'Clinical trial of chlorhexidine and diaminodiphenylsulphone in superficial ocular infections.'?,"Yes, indirectly it does support the statement that chlorhexidine treats eye infectious disorders. The clinical trial mentioned in the statement indicates that chlorhexidine was used in a study related to ocular infections, implying its potential application as a treatment. However, without specific results from the trial, we cannot conclusively say that chlorhexidine is effective in treating eye infections based solely on this information." +7869752,Chlorhexidine treats gingivitis,1411,"The abrasiveness of the chew, rather than the antibacterial activity of chlorhexidine, is likely to have contributed the most to the maintenance of oral health in dogs with mild gingivitis.",False,"Is the triple 'Chlorhexidine treats gingivitis' supported by the sentence: 'The abrasiveness of the chew, rather than the antibacterial activity of chlorhexidine, is likely to have contributed the most to the maintenance of oral health in dogs with mild gingivitis.'?","No, the statement does not provide indirect support for the phrase ""Chlorhexidine treats gingivitis."" The given statement suggests that an abrasive property of a chew is primarily responsible for maintaining oral health in dogs with mild gingivitis, rather than chlorhexidine's antibacterial activity. This implies that chlorhexidine may not be the main factor in treating gingivitis in dogs, which contradicts the claim that chlorhexidine treats gingivitis." +7287519,Chlorhexidine treats periodontitis,1412,Assessing the effectiveness of locally delivered chlorhexidine in the treatment of periodontitis.,True,Is the triple 'Chlorhexidine treats periodontitis' supported by the sentence: 'Assessing the effectiveness of locally delivered chlorhexidine in the treatment of periodontitis.'?,"Yes, the statement ""Assessing the effectiveness of locally delivered chlorhexidine in the treatment of periodontitis"" does provide indirect support for the phrase ""Chlorhexidine treats periodontitis."" This is because it implies that chlorhexidine is being used as an intervention for periodontitis, which suggests that it has some level of efficacy in treating the condition. However, it is important to note that this does not constitute direct evidence; further investigation would be required to establish a definitive causal relationship between chlorhexidine use and improvements in periodontitis symptoms." +7281939,Chlorhexidine treats Acanthamoeba keratitis,1413,Treatment of acanthamoeba keratitis with chlorhexidine.,True,Is the triple 'Chlorhexidine treats Acanthamoeba keratitis' supported by the sentence: 'Treatment of acanthamoeba keratitis with chlorhexidine.'?,"Yes, the statement ""Treatment of acanthamoeba keratitis with chlorhexidine"" does provide indirect support for the phrase ""Chlorhexidine treats Acanthamoeba keratitis."" This is because treatment generally implies that there is an effect observed in resolving or alleviating the condition (in this case Acanthamoeba keratitis), which suggests that chlorhexidine has some therapeutic benefit against this specific infection. However, it is important to note that indirect support does not necessarily equate to definitive proof; further investigation would be required to establish a direct causal relationship between chlorhexidine usage and successful treatment outcomes for Acanthamoeba keratitis." +22179313,Nicergoline treats depressive disorder,1414,"The Efficacy of Sertraline, Escitalopram, and Nicergoline in the Treatment of Depression and Apathy in Alzheimer's Disease: The Okayama Depression and Apathy Project (ODAP).BACKGROUND: Neuropsychiatric symptoms of dementia such as depression and apathy in patients with Alzheimer's disease (AD) are associated with a lower quality of life.",False,"Is the triple 'Nicergoline treats depressive disorder' supported by the sentence: 'The Efficacy of Sertraline, Escitalopram, and Nicergoline in the Treatment of Depression and Apathy in Alzheimer's Disease: The Okayama Depression and Apathy Project (ODAP).BACKGROUND: Neuropsychiatric symptoms of dementia such as depression and apathy in patients with Alzheimer's disease (AD) are associated with a lower quality of life.'?","No, the statement does not provide direct support for the claim that Nicergoline treats depressive disorder. The Okayama Depression and Apathy Project (ODAP) study mentioned in the statement investigates the efficacy of Sertraline, Escitalopram, and Nicergoline in treating depression and apathy in Alzheimer's disease patients. However, it does not explicitly state that Nicergoline is effective in treating depressive disorder in general population without Alzheimer's disease. Further investigation is required to make such conclusions about Nicergoline's effectiveness in treating depressive disorders outside of Alzheimer's disease context." +9203015,Nicergoline treats dementia,1415,"OBJECTIVES: To determine whether there is evidence of efficacy of nicergoline in the treatment of dementia and other age-associated forms of cognitive decline,and to assess the safety and tolerability of the drug.",False,"Is the triple 'Nicergoline treats dementia' supported by the sentence: 'OBJECTIVES: To determine whether there is evidence of efficacy of nicergoline in the treatment of dementia and other age-associated forms of cognitive decline,and to assess the safety and tolerability of the drug.'?","No, the phrase ""Nicergoline treats dementia"" does not receive direct support from the statement provided. The statement describes an objective to determine if there is evidence of efficacy (treatment effect) of nicergoline in treating dementia and other forms of cognitive decline, as well as assessing its safety and tolerability. However, it does not confirm that nicergoline treats dementia; it only mentions that there is an intention to investigate its potential as a treatment option. The actual results and evidence from such a study would need to be evaluated for definitive support." +22026892,RAMUCIRUMAB treats adenocarcinoma,1416,"Methods: In this retrospective two-center study, 56 patients with metastatic gastric cancer (47%) or adenocarcinoma of the GEJ (53%) were treated with paclitaxel and ramucirumab (n=38) as second-line (75%) or beyond second-line (25%) therapy.",False,"Is the triple 'RAMUCIRUMAB treats adenocarcinoma' supported by the sentence: 'Methods: In this retrospective two-center study, 56 patients with metastatic gastric cancer (47%) or adenocarcinoma of the GEJ (53%) were treated with paclitaxel and ramucirumab (n=38) as second-line (75%) or beyond second-line (25%) therapy.'?","No, the statement does not provide direct support for the claim that ""RAMUCIRUMAB treats adenocarcinoma"". The statement describes a retrospective study where patients with metastatic gastric cancer or adenocarcinoma of the gastroesophageal junction (GEJ) were treated with paclitaxel and ramucirumab as second-line or beyond second-line therapy. However, it does not specify whether ramucirumab was effective in treating adenocarcinoma in these patients. Therefore, it only provides indirect evidence at best, as it suggests that ramucirumab was used in treating adenocarcinoma but does not confirm its efficacy in doing so." +21622108,RAMUCIRUMAB treats non-small cell lung carcinoma,1417,This study aimed to validate the primary prophylactic use of pegfilgrastim with docetaxel and ramucirumab treatment in Japanese patients with NSCLC.,True,Is the triple 'RAMUCIRUMAB treats non-small cell lung carcinoma' supported by the sentence: 'This study aimed to validate the primary prophylactic use of pegfilgrastim with docetaxel and ramucirumab treatment in Japanese patients with NSCLC.'?,"Yes, indirect support can be inferred from the statement provided. The study aims to validate the use of ramucirumab in combination with docetaxel for primary prophylactic purposes in Japanese patients with non-small cell lung carcinoma (NSCLC). This suggests that ramucirumab is being investigated for its potential therapeutic benefits in treating NSCLC, even though it does not explicitly state that ramucirumab treats NSCLC on its own. However, it is important to note that further investigation is necessary to establish direct evidence for ramucirumab's efficacy in treating NSCLC independently." +21474987,RAMUCIRUMAB treats hepatocellular carcinoma,1418,Cost-effectiveness analysis of ramucirumab treatment for patients with hepatocellular carcinoma who progressed on sorafenib with alpha-fetoprotein concentrations of at least 400 ng/ml.,True,Is the triple 'RAMUCIRUMAB treats hepatocellular carcinoma' supported by the sentence: 'Cost-effectiveness analysis of ramucirumab treatment for patients with hepatocellular carcinoma who progressed on sorafenib with alpha-fetoprotein concentrations of at least 400 ng/ml.'?,"Yes, indirect support can be inferred from the statement provided. The key term here is ""indirect support,"" which means that while the statement does not explicitly confirm that ramucirumab treats hepatocellular carcinoma (HCC), it does suggest that ramucirumab is being studied as a potential treatment for HCC patients who have progressed on sorafenib therapy. + + Specifically, the statement refers to a cost-effectiveness analysis of ramucirumab treatment for patients with HCC who have progressed on sorafenib therapy and have alpha-fetoprotein concentrations of at least 400 ng/ml. This implies that ramucirumab is being considered as an option for treating these patients, as cost-effectiveness analyses typically evaluate interventions that have some potential for being beneficial in practice. + + However, it is important to note that indirect support does not equate to definitive proof or direct evidence that ramucirumab treats HCC. Additional studies and evidence would be required to establish such a claim conclusively." +23342893,TAFASITAMAB treats diffuse large B-cell lymphoma,1419,Lenalidomide was recently approved in combination with the anti-monoclonal B-cell antibody tafasitamab for patients with relapsed DLBCL after 1 to 3 previous treatments.,True,Is the triple 'TAFASITAMAB treats diffuse large B-cell lymphoma' supported by the sentence: 'Lenalidomide was recently approved in combination with the anti-monoclonal B-cell antibody tafasitamab for patients with relapsed DLBCL after 1 to 3 previous treatments.'?,"Yes, indirectly it does support that tafasitamab treats diffuse large B-cell lymphoma (DLBCL). The statement indicates that lenalidomide was approved in combination with tafasitamab for patients with relapsed DLBCL after 1 to 3 previous treatments. This implies that tafasitamab is an active component in treating DLBCL, even though the primary focus of the statement is on lenalidomide. However, it is essential to note that tafasitamab's efficacy in treating DLBCL is established in conjunction with lenalidomide in this specific context, rather than as a standalone treatment." +22828138,Thioctic acid treats cystinuria,1420,Tolvaptan and a-Lipoic acid were also tested in patients with cystinuria and resulted in reduction of recurrence.,True,Is the triple 'Thioctic acid treats cystinuria' supported by the sentence: 'Tolvaptan and a-Lipoic acid were also tested in patients with cystinuria and resulted in reduction of recurrence.'?,"Yes, there is indirect support for the statement ""Thioctic acid treats cystinuria"" based on the provided evidence. The statement ""Tolvaptan and a-Lipoic acid were also tested in patients with cystinuria and resulted in reduction of recurrence"" suggests that two different compounds were found effective in treating cystinuria (a kidney stone disorder caused by an amino acid metabolism defect). The term ""a-Lipoic acid"" is another name for Thioctic acid. Therefore, since Thioctic acid (a-Lipoic acid) was found effective in reducing cystinuria recurrence in patients, it indirectly supports the claim that Thioctic acid treats cystinuria. However, it is important to note that more extensive clinical trials would be needed for definitive conclusions regarding its therapeutic efficacy in treating cystinuria." +21111424,Thioctic acid treats optic neuritis,1421,"Conclusion: Six weeks of oral lipoic acid supplementation after acute optic neuritis is safe and well tolerated; however, because of insufficient recruitment, we could not conclude that lipoic acid treatment was neuroprotective in acute optic neuritis.",False,"Is the triple 'Thioctic acid treats optic neuritis' supported by the sentence: 'Conclusion: Six weeks of oral lipoic acid supplementation after acute optic neuritis is safe and well tolerated; however, because of insufficient recruitment, we could not conclude that lipoic acid treatment was neuroprotective in acute optic neuritis.'?","No, the phrase ""Thioctic acid treats optic neuritis"" does not receive indirect support from the statement provided. The statement discusses a study on oral lipoic acid supplementation after acute optic neuritis, but it does not provide evidence that lipoic acid (also known as thioctic acid) has any therapeutic effect on optic neuritis. Instead, it only concludes that such supplementation is safe and well-tolerated in patients with acute optic neuritis. The study did not find sufficient evidence to conclude that lipoic acid treatment was neuroprotective in acute optic neuritis due to insufficient recruitment for statistical power. Thus, there is no support for thioctic acid treating optic neuritis based on the given statement." +14414806,Thioctic acid treats carpal tunnel syndrome,1422,Treatment of carpal tunnel syndrome with alpha-lipoic acid.,True,Is the triple 'Thioctic acid treats carpal tunnel syndrome' supported by the sentence: 'Treatment of carpal tunnel syndrome with alpha-lipoic acid.'?,"Yes, there is indirect support for the statement ""Thioctic acid treats carpal tunnel syndrome"" based on the provided information that alpha-lipoic acid can be used in its treatment. Thioctic acid is another name for alpha-lipoic acid; therefore, it can be inferred that thioctic acid may also be effective in treating carpal tunnel syndrome. However, it is important to note that further investigation would be necessary to establish direct causality and understand potential side effects or limitations associated with using thioctic acid specifically for carpal tunnel syndrome treatment." +11271151,Thioctic acid treats skin disorder,1423,Alpha-Lipoic acid-based PPARgamma agonists for treating inflammatory skin diseases.,True,Is the triple 'Thioctic acid treats skin disorder' supported by the sentence: 'Alpha-Lipoic acid-based PPARgamma agonists for treating inflammatory skin diseases.'?,"Yes, there is indirect support for the statement ""Thioctic acid treats skin disorder"" from the provided evidence: ""Alpha-Lipoic acid-based PPARgamma agonists for treating inflammatory skin diseases."" + + + + The key term that provides indirect support is ""Alpha-Lipoic acid."" Alpha-Lipoic acid is also known as Thioctic acid (1). Thioctic acid has antioxidant properties (2), which can help protect skin cells from damage (3). Moreover, it has been shown that Thioctic acid can act as a PPAR-gamma agonist (4), which is a target for treating inflammatory skin diseases (5). Therefore, based on these connections between Alpha-Lipoic acid (Thioctic acid) and its potential benefits for treating inflammatory skin disorders, one could infer indirect support for the initial claim that Thioctic acid treats skin disorders. + + + + 1) https://www.ncbi.nlm.nih.gov/books/NBK557845/ + 2) https://www.ncbi.nl" +9864403,Thioctic acid treats multiple sclerosis,1424,"For study of antioxidant therapy efficiency in relapsing-remitting multiple sclerosis we investigated group 1 (18 patients) treated with alpha-lipoic acid and group 2 (14 patients) who received complex of antioxidants and neuroprotectors with various mechanisms of action (oc-lipoic acid, Nicotinamide, Acetylcysteine, Triovit Beta-carotine, Alpha-tocopheryl acetate, Ascorbic acid, Selenium, Pentoxifylline, Cerebrolysin, Amantadine hydrochloride) during 1 month, 2 times a year.",False,"Is the triple 'Thioctic acid treats multiple sclerosis' supported by the sentence: 'For study of antioxidant therapy efficiency in relapsing-remitting multiple sclerosis we investigated group 1 (18 patients) treated with alpha-lipoic acid and group 2 (14 patients) who received complex of antioxidants and neuroprotectors with various mechanisms of action (oc-lipoic acid, Nicotinamide, Acetylcysteine, Triovit Beta-carotine, Alpha-tocopheryl acetate, Ascorbic acid, Selenium, Pentoxifylline, Cerebrolysin, Amantadine hydrochloride) during 1 month, 2 times a year.'?","No, the statement does not provide indirect support for the claim that thioctic acid (also known as alpha-lipoic acid) treats multiple sclerosis (MS). The statement describes a study where two groups of patients were given different antioxidant treatments for relapsing-remitting MS. Group 1 received alpha-lipoic acid (thioctic acid), while group 2 received a complex of antioxidants and neuroprotectors that included thioctic acid among other substances. + + However, there is no mention in the statement about the efficacy of thioctic acid specifically in treating MS. The study does not compare thioctic acid treatment to a placebo or another treatment, so it is impossible to determine whether thioctic acid has any effect on MS symptoms based on this information alone. + + In order for there to be indirect support for the claim that thioctic acid treats MS, there should be some evidence suggesting that patients in group 1 had" +8933101,Thioctic acid treats Alzheimer disease,1425,"Despite the fact that this study was small and not randomized, this is the first indication that treatment with alpha-lipoic acid might be a successful 'neuroprotective' therapy option for AD and related dementias.",False,"Is the triple 'Thioctic acid treats Alzheimer disease' supported by the sentence: 'Despite the fact that this study was small and not randomized, this is the first indication that treatment with alpha-lipoic acid might be a successful 'neuroprotective' therapy option for AD and related dementias.'?","No, the phrase ""Thioctic acid treats Alzheimer disease"" does not receive direct or indirect support from the statement provided. The statement refers specifically to alpha-lipoic acid (also known as alpha-lipoic acid or ALA) as a potential neuroprotective therapy option for Alzheimer's disease (AD) and related dementias. Thioctic acid is another name for ALA, but the statement does not explicitly connect ALA treatment to a cure for AD; it only suggests that it might be a successful neuroprotective therapy option. Furthermore, the study mentioned is described as small and not randomized, which implies that more research is needed before definitive conclusions can be drawn about ALA's effectiveness in treating AD." +8739967,Thioctic acid treats hypertensive disorder,1426,"STZ-diabetes resulted in increased blood pressure, which was partially improved by alpha-lipoic acid treatment.",False,"Is the triple 'Thioctic acid treats hypertensive disorder' supported by the sentence: 'STZ-diabetes resulted in increased blood pressure, which was partially improved by alpha-lipoic acid treatment.'?","No, the statement does not provide direct or indirect support for the claim that ""Thioctic acid treats hypertensive disorder."" The study referenced in the statement investigates streptozotocin-induced diabetes (STZ-diabetes) in rats and its impact on blood pressure, as well as the effects of alpha-lipoic acid treatment on blood pressure. While thioctic acid is another name for alpha-lipoic acid, there is no mention in the statement that thioctic acid specifically treats hypertensive disorders. The statement only suggests that alpha-lipoic acid may have some beneficial effects on blood pressure in diabetic rats, which does not necessarily translate to treating hypertension in humans. + + Additionally, it is important to consider that studies conducted in animal models do not always yield comparable results in human trials due to differences in physiology, genetics, and environmental factors. Therefore, drawing conclusions based on animal studies should be done cautiously, considering their limitations in predicting human outcomes. + + In summary, while alpha-lipoic acid may have some impact on blood pressure in diabetic rats, it does not provide direct evidence that" +7865558,Thioctic acid treats type 2 diabetes mellitus,1427,"AIMS: Thioctic acid (TA), glibenclamide and acarbose are widely used to either alone or concomitantly treat patients suffering from noninsulin-dependent diabetes (NIDDM).",False,"Is the triple 'Thioctic acid treats type 2 diabetes mellitus' supported by the sentence: 'AIMS: Thioctic acid (TA), glibenclamide and acarbose are widely used to either alone or concomitantly treat patients suffering from noninsulin-dependent diabetes (NIDDM).'?","No, the statement does not provide direct support for the claim that ""Thioctic acid treats type 2 diabetes mellitus"". The AIMS statement only mentions that Thioctic acid (TA), along with glibenclamide and acarbose, is used in treating patients with noninsulin-dependent diabetes (NIDDM), which is another term for type 2 diabetes mellitus. However, it does not specify that TA treats type 2 diabetes mellitus; it only states that it is used in its treatment regimen either alone or in combination with other drugs. To support the claim that Thioctic acid treats type 2 diabetes mellitus, there would need to be evidence demonstrating its specific therapeutic effect on the disease." +7603474,Thioctic acid treats diabetic neuropathy,1428,"A two-central randomised single-blind placebo-controlled study was conducted to assess efficacy of intravenous administration of trometamol salt of thioctic (alpha-lipoic) acid (Thioctacid 600, ""ASTA Medica"", Germany) in 200 ml of physiological solution in 40 non-insulin dependent diabetic patients with symptomatic diabetic neuropathy.",True,"Is the triple 'Thioctic acid treats diabetic neuropathy' supported by the sentence: 'A two-central randomised single-blind placebo-controlled study was conducted to assess efficacy of intravenous administration of trometamol salt of thioctic (alpha-lipoic) acid (Thioctacid 600, ""ASTA Medica"", Germany) in 200 ml of physiological solution in 40 non-insulin dependent diabetic patients with symptomatic diabetic neuropathy.'?","Yes, the statement does provide indirect support for the claim that thioctic acid treats diabetic neuropathy. The study described is a randomised single-blind placebo-controlled trial, which is a robust experimental design that minimizes bias and allows for causal inferences. The fact that it was conducted on non-insulin dependent diabetic patients with symptomatic diabetic neuropathy who were administered thioctic acid (also known as alpha-lipoic acid) specifically indicates that the researchers were studying the potential effects of thioctic acid on diabetic neuropathy. + + However, it is important to note that while this study design provides some level of support for the claim, it does not constitute definitive proof that thioctic acid treats diabetic neuropathy. The results of the study would need to be analyzed in detail to determine whether thioctic acid had a statistically significant positive effect compared to the placebo group. Additionally, even if the study found a significant effect, it would only apply to the specific population studied (non-insulin dependent diabetic patients), dosage used (600 mg), and route of administration (intravenous). Therefore," +21616335,Ampicillin treats Infection,1429,"Penicillin Allergy in Pregnancy: Moving From ""Rash"" Decisions to Accurate Diagnosis.The emergence of beta-lactam-resistant pathogenic organisms has resulted in limitation or even elimination of drugs such as penicillin and ampicillin from available antibiotic choices for treating common infections in obstetrics and gynecology.",False,"Is the triple 'Ampicillin treats Infection' supported by the sentence: 'Penicillin Allergy in Pregnancy: Moving From ""Rash"" Decisions to Accurate Diagnosis.The emergence of beta-lactam-resistant pathogenic organisms has resulted in limitation or even elimination of drugs such as penicillin and ampicillin from available antibiotic choices for treating common infections in obstetrics and gynecology.'?","No, the statement ""Ampicillin treats Infection"" does not receive indirect support from the provided excerpt. In fact, it suggests quite the contrary. The passage mentions that due to the emergence of beta-lactam-resistant pathogenic organisms, drugs like penicillin and ampicillin have become limited or eliminated as antibiotic choices for common infections in obstetrics and gynecology. This implies that these drugs may no longer be as effective in treating infections, rather than supporting their efficacy." +16205290,Ampicillin treats chorioamnionitis,1430,"The patient was treated with pressors and antibiotics and was admitted to the medical intensive care unit where she received ampicillin, gentamycin, and clindamycin for suspected chorioamnionitis.",True,"Is the triple 'Ampicillin treats chorioamnionitis' supported by the sentence: 'The patient was treated with pressors and antibiotics and was admitted to the medical intensive care unit where she received ampicillin, gentamycin, and clindamycin for suspected chorioamnionitis.'?","Yes, the statement does provide indirect support for the phrase ""Ampicillin treats chorioamnionitis."" The patient in question was diagnosed with suspected chorioamnionitis and was treated with ampicillin as part of a broader antibiotic regimen in the intensive care unit (ICU). This suggests that ampicillin is used in treating chorioamnionitis since it was administered as part of the treatment for that specific condition in this case. However, it is important to note that chorioamnionitis can be caused by various microorganisms, so ampicillin might not be effective against all causative agents. Moreover, it was used in combination with gentamycin and clindamycin, which might indicate that ampicillin alone may not be sufficient for treating chorioamnionitis in some cases. Nonetheless, there is an association between ampicillin usage and chorioamnionitis treatment in this scenario." +15830384,Ampicillin treats bacterial infectious disease,1431,Based on these results aztreonam appears to be at least as effective as and possibly more effective than amikacin when used initially with ampicillin for empiric treatment of neonatal bacterial infections.,True,Is the triple 'Ampicillin treats bacterial infectious disease' supported by the sentence: 'Based on these results aztreonam appears to be at least as effective as and possibly more effective than amikacin when used initially with ampicillin for empiric treatment of neonatal bacterial infections.'?,"Yes, the statement does provide indirect support for the phrase ""Ampicillin treats bacterial infectious disease"". The statement suggests that ampicillin is used in combination with other antibiotics (aztreonam in this case) for empiric treatment of neonatal bacterial infections. This implies that ampicillin has antibacterial properties and is therefore used to treat bacterial infections. However, it should be noted that the statement does not directly prove that ampicillin treats bacterial infections as it is presented in the context of combination therapy." +14976711,Ampicillin treats osteomyelitis,1432,"When antibiotic therapy was delayed for seven days, osteomyelitis developed in four of eight animals treated locally with microencapsulated ampicillin and in six of eight animals that received parenteral ampicillin therapy.",True,"Is the triple 'Ampicillin treats osteomyelitis' supported by the sentence: 'When antibiotic therapy was delayed for seven days, osteomyelitis developed in four of eight animals treated locally with microencapsulated ampicillin and in six of eight animals that received parenteral ampicillin therapy.'?","Yes, indirect support can be inferred from the statement provided. The development of osteomyelitis in animals treated locally with microencapsulated ampicillin and in animals that received parenteral ampicillin therapy suggests that ampicillin may not be completely effective in treating osteomyelitis in all cases when administered alone. However, it does not explicitly state that ampicillin treats osteomyelitis effectively when administered promptly or in combination with other treatments. Therefore, while there is some positive correlation between ampicillin use and reduced osteomyelitis incidence, further investigation is required for definitive conclusions about ampicillin as an osteomyelitis treatment." +12551965,Ampicillin treats Sepsis,1433,"In the present study, we validated the antagonism in combinations of VCM with other beta-lactams, i.e., flomoxef (FMOX), ampicillin (AMPC), azthreonam (AZT) and imipenem/cilastatin (IPM/CS), in systemic infections and pneumoniain in mice.",False,"Is the triple 'Ampicillin treats Sepsis' supported by the sentence: 'In the present study, we validated the antagonism in combinations of VCM with other beta-lactams, i.e., flomoxef (FMOX), ampicillin (AMPC), azthreonam (AZT) and imipenem/cilastatin (IPM/CS), in systemic infections and pneumoniain in mice.'?","No, the statement does not provide direct support for the claim that ""Ampicillin treats Sepsis"". The study mentioned in the statement tested various antibiotic combinations in mice models for systemic infections and pneumonia; however, it did not explicitly investigate their efficacy against sepsis. Therefore, while ampicillin may have antimicrobial properties that could potentially be useful in treating sepsis, we cannot infer from this statement alone that it is an effective treatment for sepsis. Further investigation would be required for such a conclusion." +9906170,Ampicillin treats bacterial meningitis,1434,"The mortality rate in this type of BM is still high among those treated with ampicillin or penicillin, and a decrease in the mortality rate was not observed when the reported cases in Spain in the last 30 years were analyzed.",False,"Is the triple 'Ampicillin treats bacterial meningitis' supported by the sentence: 'The mortality rate in this type of BM is still high among those treated with ampicillin or penicillin, and a decrease in the mortality rate was not observed when the reported cases in Spain in the last 30 years were analyzed.'?","No, the statement does not provide indirect support for the phrase ""Ampicillin treats bacterial meningitis"". In fact, it seems to suggest that ampicillin (and penicillin) may not be effective in treating bacterial meningitis (BM), as there is no observed decrease in mortality rate among those treated with these antibiotics over the past 30 years in Spain. This raises concerns about their efficacy against BM. However, it is important to consider additional evidence from clinical trials and other studies before making definitive conclusions about ampicillin's effectiveness in treating bacterial meningitis." +8394714,Ampicillin treats gonorrhea,1435,Ampicillin has assumed a prominent role in the treatment of gonorrhoea.,True,Is the triple 'Ampicillin treats gonorrhea' supported by the sentence: 'Ampicillin has assumed a prominent role in the treatment of gonorrhoea.'?,"Yes, the statement ""Ampicillin has assumed a prominent role in the treatment of gonorrhea"" does provide indirect support for the phrase ""Ampicillin treats gonorrhea."" This is because assuming a prominent role in treatment implies that the drug is effective against the condition, which is gonorrhea in this case. However, it is important to note that ""treats"" is a general term that doesn't specify the degree or extent of effectiveness. Therefore, while there is support for ampicillin having some level of efficacy in treating gonorrhea, the statement doesn't necessarily imply that ampicillin is the most effective treatment available or that it works in all cases." +7166712,Ampicillin treats pneumonia,1436,[Clinical efficacy of sulbactam/ampicillin in comparison with cefotiam in the treatment of elderly patients with pneumonia].,True,Is the triple 'Ampicillin treats pneumonia' supported by the sentence: '[Clinical efficacy of sulbactam/ampicillin in comparison with cefotiam in the treatment of elderly patients with pneumonia].'?,"Yes, indirectly it does lend support. The title suggests that ampicillin is being used in combination with sulbactam for treating pneumonia in elderly patients. The fact that such a study was conducted implies that there is some basis for believing that ampicillin could be an effective treatment for pneumonia. However, it doesn't directly prove that ampicillin alone treats pneumonia because in this study it is used in combination with sulbactam. Therefore, further research would be needed to confirm whether ampicillin alone is effective against pneumonia." +22520021,Carbenicillin treats bacterial infectious disease,1437,In this study results of treatment with ceftazidime were superior to results of treatment with amikacin/carbenicillin for invasive bacterial infections of newborn infants.,True,Is the triple 'Carbenicillin treats bacterial infectious disease' supported by the sentence: 'In this study results of treatment with ceftazidime were superior to results of treatment with amikacin/carbenicillin for invasive bacterial infections of newborn infants.'?,"Yes, indirectly it does support that Carbenicillin can treat bacterial infectious disease in newborn infants when used in combination therapy with amikacin. The statement suggests that ceftazidime was more effective than amikacin/carbenicillin in treating invasive bacterial infections in newborn infants; however, it still implies that carbenicillin has some efficacy against bacterial infections in newborn infants when used in combination therapy. The fact that carbenicillin was used in a clinical trial for treating bacterial infections in newborn infants suggests that it is considered as a potential treatment option for bacterial infectious diseases in that population. + + That being said, it is important to note that carbenicillin is not always considered a first-line treatment for bacterial infections due to its narrower spectrum compared to some other antibiotics like ceftazidime. Moreover, adverse effects such as allergic reactions should be taken into account when prescribing carbenicillin. The combination therapy using carbenicillin may have its own set of benefits and drawbacks that need careful evaluation in specific clinical" +26119472,Bacampicillin treats bacterial infectious disease,1438,Clinical trial of bacampicillin in acute bacterial infections.,True,Is the triple 'Bacampicillin treats bacterial infectious disease' supported by the sentence: 'Clinical trial of bacampicillin in acute bacterial infections.'?,"Yes, the statement ""Clinical trial of bacampicillin in acute bacterial infections"" does provide indirect support for the claim that ""Bacampicillin treats bacterial infectious disease."" This is because conducting a clinical trial on bacampicillin specifically for acute bacterial infections suggests that there is an underlying assumption that bacampicillin has some therapeutic effect on bacterial infections. However, it is important to note that direct evidence from the statement is lacking; it does not explicitly state that bacampicillin treats bacterial infectious disease. To confirm this claim fully, one would need access to more specific information from the clinical trial such as its results and conclusions regarding bacampicillin's efficacy in treating bacterial infections." +25659721,Aspoxicillin treats bacterial infectious disease,1439,The above results suggest that ASPC is an useful antibiotic for treating pediatric bacterial infections.,True,Is the triple 'Aspoxicillin treats bacterial infectious disease' supported by the sentence: 'The above results suggest that ASPC is an useful antibiotic for treating pediatric bacterial infections.'?,"Yes, the statement ""The above results suggest that ASPC is an useful antibiotic for treating pediatric bacterial infections"" does provide indirect support for the phrase ""Aspoxicillin treats bacterial infectious disease."" This is because Aspoxicillin (ASPC) is a type of antibiotic, which is defined as a substance that inhibits the growth of bacteria. Therefore, if ASPC is found to be useful in treating pediatric bacterial infections, it implies that Aspoxicillin has antibacterial properties that allow it to treat bacterial infectious diseases in general, not only in pediatric patients but also in other populations. However, it is important to note that direct evidence from clinical trials or experiments specifically demonstrating Aspoxicillin's effectiveness against bacterial infections would provide stronger support for the claim that Aspoxicillin treats bacterial infectious disease." +13845936,Mezlocillin treats bacterial infectious disease,1440,"An open, multicentre study was performed in hospital in-patients at a total of 12 German hospitals to investigate the efficacy and tolerability of sulbactam combined with mezlocillin, piperacillin or cefotaxime in severe bacterial infections.",True,"Is the triple 'Mezlocillin treats bacterial infectious disease' supported by the sentence: 'An open, multicentre study was performed in hospital in-patients at a total of 12 German hospitals to investigate the efficacy and tolerability of sulbactam combined with mezlocillin, piperacillin or cefotaxime in severe bacterial infections.'?","Yes, indirectly it does support the claim that mezlocillin treats bacterial infectious disease. The statement mentions an open, multicentre study conducted in German hospitals investigating the efficacy and tolerability of sulbactam combined with mezlocillin in treating severe bacterial infections. The fact that mezlocillin is being studied in combination with sulbactam for treating severe bacterial infections suggests that mezlocillin has antibacterial properties that could potentially be useful for treating bacterial infectious diseases. However, it is important to note that more direct evidence would be needed before making a definitive conclusion about mezlocillin's effectiveness in treating bacterial infections, such as clinical trial results demonstrating its efficacy compared to placebo or alternative treatments." +7407212,Benzoyl Peroxide treats acne,1441,"Treatments for acne can be topical or systemic, and include retinoids, antibiotics, benzoyl peroxide, azelaic acid, and hormonal therapy.",True,"Is the triple 'Benzoyl Peroxide treats acne' supported by the sentence: 'Treatments for acne can be topical or systemic, and include retinoids, antibiotics, benzoyl peroxide, azelaic acid, and hormonal therapy.'?","Yes, the phrase ""Benzoyl Peroxide treats acne"" does receive indirect support from the statement: ""Treatments for acne can be topical or systemic, and include retinoids, antibiotics, benzoyl peroxide, azelaic acid, and hormonal therapy."" + + The statement lists Benzoyl Peroxide as one of the treatments for acne, which implies that it has been found to be effective in treating acne. Therefore, it lends credence to the claim that Benzoyl Peroxide treats acne. However, it is important to note that this is indirect support because the original statement does not explicitly state that Benzoyl Peroxide treats acne, but rather includes it in a list of treatments." +26328908,Proglumide treats peptic ulcer disease,1442,[Controlled and double-blind study of the treatment of peptic ulcer with cimetidine and proglumide].,True,Is the triple 'Proglumide treats peptic ulcer disease' supported by the sentence: '[Controlled and double-blind study of the treatment of peptic ulcer with cimetidine and proglumide].'?,"Yes, indirect support can be inferred from the statement. The fact that a controlled and double-blind study was conducted on the treatment of peptic ulcer using both cimetidine and proglumide implies that there is some scientific interest in investigating proglumide as a potential treatment for peptic ulcer disease. However, it does not provide direct evidence that proglumide alone treats peptic ulcer disease since the study involved comparing it against another treatment (cimetidine). To establish more robust support for proglumide as an effective treatment for peptic ulcer disease, further investigation would be required through additional studies specifically focusing on proglumide monotherapy, its efficacy compared to placebo, as well as its safety profile in treating peptic ulcers." +13022426,Pirenzepine treats gastroesophageal reflux disease,1443,Pirenzepine may provide a unique alternative for some GERD patients who may be refractory to other therapies of GERD.,True,Is the triple 'Pirenzepine treats gastroesophageal reflux disease' supported by the sentence: 'Pirenzepine may provide a unique alternative for some GERD patients who may be refractory to other therapies of GERD.'?,"Yes, the statement ""Pirenzepine may provide a unique alternative for some GERD patients who may be refractory to other therapies of GERD"" does lend indirect support to the claim that ""Pirenzepine treats gastroesophageal reflux disease (GERD)"". The key phrase here is ""treats gastroesophageal reflux disease"", which can be interpreted as an effective therapy for managing GERD symptoms. + + The statement suggests that Pirenzepine may be beneficial for certain GERD patients who have not responded well to other treatments. This implies that Pirenzepine has some efficacy in treating GERD symptoms, even if it is not the first-line treatment for all patients. Therefore, it does provide indirect support for the claim that Pirenzepine can treat GERD. However, it is essential to note that this does not constitute direct evidence; further investigation would be necessary to confirm Pirenzepine's effectiveness as a GERD treatment fully." +10839963,Pirenzepine treats peptic ulcer disease,1444,Four hundred and two patients with peptic ulcer were selected for acute therapy with either pirenzepine (100 mg/day) or cimetidine (800 mg/day) using the envelope method.,False,Is the triple 'Pirenzepine treats peptic ulcer disease' supported by the sentence: 'Four hundred and two patients with peptic ulcer were selected for acute therapy with either pirenzepine (100 mg/day) or cimetidine (800 mg/day) using the envelope method.'?,"No, the statement does not provide direct or indirect support for the claim that ""Pirenzepine treats peptic ulcer disease."" The statement only mentions that 402 patients were selected for acute therapy using either pirenzepine or cimetidine, but it does not provide any information about the outcomes of these treatments or whether pirenzepine was found to be effective in treating peptic ulcer disease specifically. Therefore, based on this statement alone, we cannot infer that pirenzepine is an effective treatment for peptic ulcer disease." +16332442,Magnesium Oxide treats autosomal recessive inherited pseudoxanthoma elasticum,1445,"In that context, magnesium oxide significantly reduced CIMT in PXE mice, and may be useful for disease prevention in PXE patients.",False,"Is the triple 'Magnesium Oxide treats autosomal recessive inherited pseudoxanthoma elasticum' supported by the sentence: 'In that context, magnesium oxide significantly reduced CIMT in PXE mice, and may be useful for disease prevention in PXE patients.'?","No, the phrase ""Magnesium Oxide treats autosomal recessive inherited pseudoxanthoma elasticum (PXE)"" does not receive indirect support from the statement: ""In that context, magnesium oxide significantly reduced CIMT in PXE mice, and may be useful for disease prevention in PXE patients."" + + The statement suggests that magnesium oxide may help reduce CIMT (carotid intima-media thickness) in PXE mice, which could potentially be useful for preventing disease progression in PXE patients. However, it does not explicitly mention that magnesium oxide treats autosomal recessive inherited pseudoxanthoma elasticum (PXE) itself; it only implies that it might help manage some symptoms (CIMT reduction) associated with PXE in mice models. + + Moreover, even though there is a correlation between magnesium oxide supplementation and reduced CIMT in PXE mice, it does not necessarily mean that magnesium oxide can treat PXE in humans because: + + 1) The study was conducted on mice (animal models" +15225864,Magnesium Oxide treats constipation disorder,1446,"This report presents the rare case of a 75-year-old woman who developed a rectal obstruction caused by a pharmacobezoar, following the long-term ingestion of magnesium oxide cathartics for constipation.",True,"Is the triple 'Magnesium Oxide treats constipation disorder' supported by the sentence: 'This report presents the rare case of a 75-year-old woman who developed a rectal obstruction caused by a pharmacobezoar, following the long-term ingestion of magnesium oxide cathartics for constipation.'?","Yes, indirectly it does lend some support. The statement provides evidence that magnesium oxide was used over an extended period as a cathartic (a medication that stimulates bowel movements) for treating constipation in a 75-year-old woman. The woman subsequently developed a rectal obstruction due to a pharmacobezoar (a mass formed by undigested medication). While magnesium oxide did not prevent constipation in this case, it still played a direct role in managing constipation symptoms, albeit unsuccessfully in the long term due to the development of complications. + + However, it is important to note that this single case report does not necessarily constitute definitive evidence for the general efficacy of magnesium oxide in treating constipation disorder due to several factors including individual variation in response to medication, potential confounding factors in the case report itself, as well as limitations in sample size. Further studies would be required to establish more robust evidence for its efficacy in treating constipation disorder." +26045826,Ticarcillin treats Sepsis,1447,Mezlocillin and ticarcillin in the treatment of patients with serious systemic infections.,True,Is the triple 'Ticarcillin treats Sepsis' supported by the sentence: 'Mezlocillin and ticarcillin in the treatment of patients with serious systemic infections.'?,"Yes, indirectly it does lend some support. The statement ""Mezlocillin and ticarcillin in the treatment of patients with serious systemic infections"" suggests that both Mezlocillin and Ticarcillin are used in treating severe systemic infections, which can include Sepsis. However, it doesn't specifically mention Sepsis as a condition treated by Ticarcillin. Therefore, while not direct, there is an implication that Ticarcillin could be used in treating Sepsis as part of treating severe systemic infections. But remember, this is an indirect inference based on a broader claim about systemic infections, not a direct claim about Sepsis treatment." +9410149,Ticarcillin treats osteomyelitis,1448,Obviously unbalanced comparative studies showed some benefit of ticarcillin for bone infections caused by Pseudomonas species.,True,Is the triple 'Ticarcillin treats osteomyelitis' supported by the sentence: 'Obviously unbalanced comparative studies showed some benefit of ticarcillin for bone infections caused by Pseudomonas species.'?,"Yes, the statement ""Obviously unbalanced comparative studies showed some benefit of ticarcillin for bone infections caused by Pseudomonas species"" does provide indirect support for the claim that ""Ticarcillin treats osteomyelitis."" The key term here is ""bone infections caused by Pseudomonas species,"" which is a specific type of osteomyelitis. Ticarcillin is an antibiotic that has been shown in unbalanced comparative studies (though these studies have limitations) to provide some benefit in treating these specific types of bone infections. However, it is important to note that this does not necessarily mean that ticarcillin is effective for all types of osteomyelitis, as its efficacy appears to be limited to infections caused by Pseudomonas species. Additionally, further research is needed to confirm these findings in more rigorous, balanced studies before definitive conclusions can be drawn about ticarcillin's effectiveness in treating osteomyelitis caused by Pseudomonas species." +26823243,Urea treats citrullinemia,1449,"The precursors of urea (ammonia, glutamate, glutamine and alpha-amino nitrogen) did not increase after the benzoate administration in the 6 normal subjects as well as in the 2 patients with citrullinaemia.",False,"Is the triple 'Urea treats citrullinemia' supported by the sentence: 'The precursors of urea (ammonia, glutamate, glutamine and alpha-amino nitrogen) did not increase after the benzoate administration in the 6 normal subjects as well as in the 2 patients with citrullinaemia.'?","No, the phrase ""Urea treats citrullinemia"" does not receive indirect support from the statement provided. The statement discusses the levels of certain precursors (ammonia, glutamate, glutamine, and alpha-amino nitrogen) in normal subjects and patients with citrullinemia after benzoate administration. It does not mention urea or its effects on citrullinemia. Indirect support would require connecting the concept of urea treatment for citrullinemia through related concepts or processes mentioned in the statement, but in this case, there is no such connection." +25855602,Urea treats argininosuccinic aciduria,1450,The relationship between the formation of urea and argininosuccinate in a patient with argininosuccinic aciduria studied with labelled precursors.,False,Is the triple 'Urea treats argininosuccinic aciduria' supported by the sentence: 'The relationship between the formation of urea and argininosuccinate in a patient with argininosuccinic aciduria studied with labelled precursors.'?,"No, the phrase ""Urea treats argininosuccinic aciduria"" does not receive direct support from the statement: ""The relationship between the formation of urea and argininosuccinate in a patient with argininosuccinic aciduria studied with labelled precursors."" + + The statement discusses a study involving labelled precursors in a patient with argininosuccinic aciduria, focusing on the formation of urea and argininosuccinate. However, it does not provide any information about urea as a treatment for argininosuccinic aciduria. + + Argininosuccinic aciduria is a genetic disorder characterized by an inability to break down argininosuccinic acid due to a deficiency in argininosuccinate lyase. Treatment typically involves dietary restrictions and supplementation with nitrogen-scavenging drugs that help remove excess nitrogen from the body, such as sodium phenylacetate and sodium benzoate. Urea itself is not typically used as a treatment because it cannot cross cell membranes and therefore cannot enter cells where it is needed to help remove ammonia." +19420190,Urea treats psoriasis,1451,"In the treatment of psoriasis with urea and urea-combined preparations, the individual sequence should be so clearly prescribed such that acceptance is assured.",False,"Is the triple 'Urea treats psoriasis' supported by the sentence: 'In the treatment of psoriasis with urea and urea-combined preparations, the individual sequence should be so clearly prescribed such that acceptance is assured.'?","No, the statement does not provide direct or indirect support for the claim that ""urea treats psoriasis"". The statement only suggests that there is a specific sequence in which urea-based treatments should be administered for psoriasis patients to ensure acceptance (presumably referring to patient compliance). It does not imply that urea itself is an active ingredient in treating psoriasis. Additional evidence would be required to establish a causal relationship between urea and improvements in psoriasis symptoms." +17323203,Urea treats radiodermatitis,1452,"RESULTS: Effective treatment with urea has been reported for the following conditions: ichthyosis, xerosis, atopic dermatitis/eczema, contact dermatitis, radiation induced dermatitis, psoriasis/seborrheic dermatitis, onychomycosis, tinea pedis, keratosis, pruritus, and dystrophic nails.",True,"Is the triple 'Urea treats radiodermatitis' supported by the sentence: 'RESULTS: Effective treatment with urea has been reported for the following conditions: ichthyosis, xerosis, atopic dermatitis/eczema, contact dermatitis, radiation induced dermatitis, psoriasis/seborrheic dermatitis, onychomycosis, tinea pedis, keratosis, pruritus, and dystrophic nails.'?","Yes, the phrase ""Urea treats radiodermatitis"" does receive indirect support from the statement provided. The statement lists ""radiation induced dermatitis"" as one of the conditions that urea has been reported as an effective treatment for. Radiodermatitis is a type of skin damage caused by radiation therapy, often observed in cancer patients. Therefore, it can be inferred that urea may indeed be beneficial in treating radiodermatitis. However, it is important to note that indirect support does not equate to definitive proof. Further research would be needed to confirm these findings and establish optimal treatment protocols." +15413374,Urea treats hepatocellular carcinoma,1453,"INTRODUCTION: Sorafenib is a novel oral bis-aryl urea compound that has proven survival benefit in patients with advanced hepatocellular carcinoma (HCC), for which several therapies are currently available with unsatisfactory results.",False,"Is the triple 'Urea treats hepatocellular carcinoma' supported by the sentence: 'INTRODUCTION: Sorafenib is a novel oral bis-aryl urea compound that has proven survival benefit in patients with advanced hepatocellular carcinoma (HCC), for which several therapies are currently available with unsatisfactory results.'?","No, the statement does not provide indirect support for the claim that ""urea treats hepatocellular carcinoma."" The statement introduces sorafenib as an oral bis-aryl urea compound that has survival benefits in patients with advanced hepatocellular carcinoma (HCC). Bis-aryl urea is different from urea; hence, it does not imply that urea itself has any therapeutic effects on HCC. This misconception may arise from confusing urea (NH2CONH2) with bis-aryl urea (a derivative), but they have different chemical properties that likely contribute to sorafenib's mechanism in treating HCC rather than urea itself being an effective treatment for HCC." +12068406,Urea treats type 2 diabetes mellitus,1454,These findings are consistent with the inhibition of hepatic glycogenolysis and support the use of acyl ureas for the treatment of type 2 diabetes.,False,Is the triple 'Urea treats type 2 diabetes mellitus' supported by the sentence: 'These findings are consistent with the inhibition of hepatic glycogenolysis and support the use of acyl ureas for the treatment of type 2 diabetes.'?,"No, the statement does not provide indirect support for the claim that ""urea treats type 2 diabetes mellitus."" The given statement refers specifically to ""acyl ureas,"" not urea itself. Urea is a simple organic compound containing nitrogen that is excreted by urine; it is different from acyl ureas which contain an acyl group (a functional group consisting of a carbon atom double-bonded to an oxygen atom: C=O). Therefore, one cannot infer that urea has therapeutic potential for type 2 diabetes mellitus based on evidence supporting acyl ureas as potential therapeutic agents for diabetes management." +11649881,Urea treats Pain,1455,"Novel transient receptor potential vanilloid 1 receptor antagonists for the treatment of pain: structure-activity relationships for ureas with quinoline, isoquinoline, quinazoline, phthalazine, quinoxaline, and cinnoline moieties.",True,"Is the triple 'Urea treats Pain' supported by the sentence: 'Novel transient receptor potential vanilloid 1 receptor antagonists for the treatment of pain: structure-activity relationships for ureas with quinoline, isoquinoline, quinazoline, phthalazine, quinoxaline, and cinnoline moieties.'?","Yes, indirectly it does. The statement provides evidence that ureas have been investigated for their potential as transient receptor potential vanilloid 1 (TRPV1) receptor antagonists, which are known to play a role in pain perception. Therefore, if urea compounds can effectively antagonize TRPV1 receptors, they may indeed have an impact on pain treatment. However, it is important to note that this statement does not explicitly demonstrate that urea itself treats pain; rather, it suggests that certain urea-based compounds might have potential as pain treatments. Further investigation and clinical trials would be necessary to confirm such a claim." +10679439,Urea treats skin disorder,1456,[TROPHIC ACTION OF UREA AND ITS USE IN THE TREATMENT OF NEUROTROPHIC SKIN DISEASES].,True,Is the triple 'Urea treats skin disorder' supported by the sentence: '[TROPHIC ACTION OF UREA AND ITS USE IN THE TREATMENT OF NEUROTROPHIC SKIN DISEASES].'?,"Yes, the phrase ""Urea treats skin disorder"" does receive indirect support from the statement: ""[TROPHIC ACTION OF UREA AND ITS USE IN THE TREATMENT OF NEUROTROPHIC SKIN DISEASES]."" This is because neurotrophic skin diseases fall under the category of skin disorders. Urea's trophic action refers to its ability to improve the nutrition of skin cells, which can be beneficial in managing various skin conditions. However, it is crucial to note that such support is indirect; the statement does not explicitly confirm that urea treats all skin disorders but rather implies its potential therapeutic effect on neurotrophic skin diseases specifically." +10511987,Urea treats diabetes mellitus,1457,"[Preliminary note on the oral treatment of diabetes by N-sulfonyl-p-methylbenzene-N'-n-butyl urea or D 860, a product free of antibacterial action].",False,"Is the triple 'Urea treats diabetes mellitus' supported by the sentence: '[Preliminary note on the oral treatment of diabetes by N-sulfonyl-p-methylbenzene-N'-n-butyl urea or D 860, a product free of antibacterial action].'?","No, the statement does not provide indirect support for the claim that urea treats diabetes mellitus. The statement discusses the oral treatment of diabetes using N-sulfonyl-p-methylbenzene-N'-n-butyl urea (D 860), which is a specific chemical compound different from urea. Urea is a waste product that is not known to have any direct effects on diabetes management. Therefore, without further evidence connecting urea to diabetes treatment, it is incorrect to assume that urea can treat diabetes based on this statement about D 860." +8678587,"Urea treats dermatitis, atopic",1458,"In the present report, we compared two creams, identical with the exception that one contained both urea and sodium chloride and the other urea alone, in 22 patients with atopic dermatitis.",True,"Is the triple 'Urea treats dermatitis, atopic' supported by the sentence: 'In the present report, we compared two creams, identical with the exception that one contained both urea and sodium chloride and the other urea alone, in 22 patients with atopic dermatitis.'?","Yes, the statement does provide indirect support for the phrase ""Urea treats dermatitis, atopic"". This is because it mentions a study where two creams were compared, one containing urea alone and the other containing both urea and sodium chloride, in patients with atopic dermatitis. The fact that such a study was conducted suggests that there is some biological plausibility or existing knowledge suggesting urea could have therapeutic effects on atopic dermatitis. However, it is important to note that this study does not necessarily prove that urea alone treats atopic dermatitis, as it does not mention the results of the study or whether there were any significant differences between the two creams. Further investigation would be required to confirm whether urea does indeed have a positive effect on atopic dermatitis." +27251301,Mannitol treats brain cancer,1459,"Hyperosmolar blood-brain barrier disruption (HBBBD), produced by infusion of mannitol into the cerebral arteries, has been used in the treatment of brain tumors to increase drug delivery to tumor and adjacent brain.",True,"Is the triple 'Mannitol treats brain cancer' supported by the sentence: 'Hyperosmolar blood-brain barrier disruption (HBBBD), produced by infusion of mannitol into the cerebral arteries, has been used in the treatment of brain tumors to increase drug delivery to tumor and adjacent brain.'?","Yes, indirectly it does support the statement that mannitol can be used in treating brain cancer. The provided evidence suggests that mannitol has been used in hyperosmolar blood-brain barrier disruption (HBBBD) for increasing drug delivery to brain tumors and adjacent brain tissue. This implies that mannitol may play an essential role in brain cancer treatment by facilitating better penetration of therapeutic agents into tumor sites. However, it does not necessarily mean that mannitol itself is treating brain cancer but rather that it is enhancing treatment effectiveness when used in combination with other drugs." +21059003,Mannitol treats hearing loss disorder,1460,[Effects of mannitol on the fluids of the internal ear. Use in the treatment of deafness].,True,Is the triple 'Mannitol treats hearing loss disorder' supported by the sentence: '[Effects of mannitol on the fluids of the internal ear. Use in the treatment of deafness].'?,"Yes, the statement ""Effects of mannitol on the fluids of the internal ear. Use in the treatment of deafness"" does provide indirect support for the phrase ""Mannitol treats hearing loss disorder."" Mannitol is mentioned as having an effect on the fluids within the inner ear, which is directly related to hearing function. Additionally, its use is described in treating deafness (or hearing loss disorder). + + + + However, it is important to note that indirect support does not equate to definitive proof. Further investigation would be necessary to establish if mannitol effectively treats hearing loss disorders in various contexts, as well as any possible side effects, contraindications, optimal dosages, or therapeutic ranges that should be considered when employing mannitol for treating hearing loss disorders." +20425957,Mannitol treats osteoarthritis,1461,Objective: To assess efficacy and safety of a single intra-articular injection of 2% sodium hyaluronate plus 0.5% mannitol in patients with symptomatic osteoarthritis of the knee.,True,Is the triple 'Mannitol treats osteoarthritis' supported by the sentence: 'Objective: To assess efficacy and safety of a single intra-articular injection of 2% sodium hyaluronate plus 0.5% mannitol in patients with symptomatic osteoarthritis of the knee.'?,"Yes, indirectly it does support the claim that mannitol may have beneficial effects in treating osteoarthritis when used in conjunction with sodium hyaluronate. The statement mentions an objective to assess the efficacy and safety of a single intra-articular injection containing both 2% sodium hyaluronate and 0.5% mannitol in patients with symptomatic osteoarthritis of the knee. + + However, it is important to note that this statement does not explicitly confirm that mannitol alone treats osteoarthritis but rather implies that mannitol might have some therapeutic potential when combined with sodium hyaluronate in treating osteoarthritis symptoms. Further investigation would be necessary through clinical trials and studies specifically designed to evaluate mannitol's impact on osteoarthritis as a standalone treatment in order to confirm its direct efficacy in treating osteoarthritis." +16945033,Mannitol treats hypotensive disorder,1462,"These values were correlated with expected risk factors for lactatemia including length of surgery, Body Mass Index (BMI), hypotension, hemoglobin and mannitol therapy.",False,"Is the triple 'Mannitol treats hypotensive disorder' supported by the sentence: 'These values were correlated with expected risk factors for lactatemia including length of surgery, Body Mass Index (BMI), hypotension, hemoglobin and mannitol therapy.'?","No, the statement does not provide direct support for the claim that Mannitol treats hypotensive disorder. The passage mentions Mannitol therapy in association with hypotension as one of several risk factors for lactatemia (elevated levels of lactate in the blood). However, it does not indicate that Mannitol is used as a treatment for hypotension itself. The statement implies that hypotension is correlated with Mannitol therapy in terms of increased risk for lactatemia; it does not provide evidence that Mannitol is an effective treatment for hypotensive disorder." +12644644,Mannitol treats Pain,1463,"Further treatments with intravenous mannitol, oral carbonic anhydrase inhibitor, topical antiglaumatic agents and subconjunctival 5-fluorouracil (5-FU) injections all failed to control relapsing pain and IOP elevation.",False,"Is the triple 'Mannitol treats Pain' supported by the sentence: 'Further treatments with intravenous mannitol, oral carbonic anhydrase inhibitor, topical antiglaumatic agents and subconjunctival 5-fluorouracil (5-FU) injections all failed to control relapsing pain and IOP elevation.'?","No, the statement does not provide indirect support for the claim that ""Mannitol treats Pain"". In fact, it suggests quite the opposite: treatments including intravenous mannitol were ineffective in controlling pain and intraocular pressure (IOP) elevation. This implies that mannitol may not be an effective treatment for pain in this context. However, it is important to note that this does not definitively rule out mannitol as a potential pain treatment in other circumstances, as its efficacy could depend on various factors such as dosage, administration method, patient characteristics, and specific type/cause of pain. Nonetheless, based on the information provided in the statement, mannitol does not appear to be an effective pain treatment in this particular case." +11774217,Mannitol treats brain injury,1464,CONCLUSIONS: The results suggested that mannitol could improve cerebral perfusion in patients with mild brain damage.,True,Is the triple 'Mannitol treats brain injury' supported by the sentence: 'CONCLUSIONS: The results suggested that mannitol could improve cerebral perfusion in patients with mild brain damage.'?,"Yes, the statement ""CONCLUSIONS: The results suggested that mannitol could improve cerebral perfusion in patients with mild brain damage"" does provide indirect support for the claim that mannitol treats brain injury. The conclusion suggests that mannitol has therapeutic potential in improving cerebral perfusion in individuals who have experienced mild brain damage, which can be considered an aspect of treating brain injury as it addresses one of the consequences of such trauma. + + + + However, it is crucial to note that the evidence provided in this statement is limited in scope as it only addresses mild brain damage and cerebral perfusion improvement without exploring other potential benefits or risks associated with mannitol treatment for brain injuries. Therefore, further investigation is required before making definitive conclusions about mannitol as an effective treatment for various forms and severities of brain injuries." +11660589,Mannitol treats malaria,1465,"A possibly indulgent wish list of outcome (mortality) studies using currently known treatment modalities, however, includes the loading dose of quinine, vigorous fluid replacement, ET, the artemisinins, mannitol, and N-acetylcysteine in the treatment of severe malaria.",True,"Is the triple 'Mannitol treats malaria' supported by the sentence: 'A possibly indulgent wish list of outcome (mortality) studies using currently known treatment modalities, however, includes the loading dose of quinine, vigorous fluid replacement, ET, the artemisinins, mannitol, and N-acetylcysteine in the treatment of severe malaria.'?","Yes, while indirectly, the statement ""A possibly indulgent wish list of outcome (mortality) studies using currently known treatment modalities includes...mannitol...in the treatment of severe malaria"" does lend some support for the claim that mannitol treats malaria. + + The statement suggests that mannitol is one of the treatments being considered in studies on severe malaria treatment modalities. The fact that mannitol is included in these studies implies that there is some rationale behind investigating its potential therapeutic benefits in treating malaria. + + However, it is important to note that being included in such studies does not necessarily equate to mannitol being an established treatment for malaria. Including mannitol in these studies simply means that there is interest in exploring its potential as a therapeutic option for treating severe malaria. Therefore, further investigation is required before making any definitive conclusions about mannitol as an effective treatment for malaria based on this statement alone." +11613595,Mannitol treats chronic obstructive pulmonary disease,1466,CONCLUSION: We propose that AHR to mannitol could predict ICS-responsiveness in mild to moderately severe COPD patients.,False,Is the triple 'Mannitol treats chronic obstructive pulmonary disease' supported by the sentence: 'CONCLUSION: We propose that AHR to mannitol could predict ICS-responsiveness in mild to moderately severe COPD patients.'?,"No, the phrase ""Mannitol treats chronic obstructive pulmonary disease"" does not receive indirect support from the statement: ""CONCLUSION: We propose that AHR to mannitol could predict ICS-responsiveness in mild to moderately severe COPD patients."" + + The statement in question comes from a study investigating the potential for mannitol airway hyperresponsiveness (AHR) as a predictor for inhaled corticosteroid (ICS) responsiveness in chronic obstructive pulmonary disease (COPD) patients. The study does not claim that mannitol treats COPD; rather it suggests that mannitol AHR could be used as an indicator for ICS responsiveness in specific COPD patient populations (mild to moderately severe). + + The distinction here is crucial; while mannitol may potentially help in predicting which patients might respond better to ICS treatment (indirectly supporting better patient outcomes), it does not imply mannitol as a standalone treatment for COPD nor does it claim that mannitol has therapeutic effects on COPD symptoms." +10724016,Mannitol treats acute kidney failure,1467,MANNITOL THERAPY IN ACUTE RENAL FAILURE.,True,Is the triple 'Mannitol treats acute kidney failure' supported by the sentence: 'MANNITOL THERAPY IN ACUTE RENAL FAILURE.'?,"Yes, the statement ""MANNITOL THERAPY IN ACUTE RENAL FAILURE"" does provide indirect support for the phrase ""Mannitol treats acute kidney failure"". The term 'Mannitol Therapy' implies that Mannitol is being used as a treatment for something, in this case, it is specifically related to acute renal failure (also known as acute kidney failure). However, it is important to note that indirect support does not equate to definitive proof; further evidence would be required to confirm Mannitol's efficacy in treating acute kidney failure." +10707564,Mannitol treats injury,1468,Mannitol has a beneficial effect on ischemic injury following a short-duration forebrain ischemic insult in rats.,True,Is the triple 'Mannitol treats injury' supported by the sentence: 'Mannitol has a beneficial effect on ischemic injury following a short-duration forebrain ischemic insult in rats.'?,"Yes, the statement ""Mannitol has a beneficial effect on ischemic injury following a short-duration forebrain ischemic insult in rats"" does provide indirect support for the claim that ""Mannitol treats injury"". This is because ischemic injury is a type of injury that occurs when there is reduced blood flow to an organ or tissue, such as in the case of stroke or other conditions where blood supply is compromised. Mannitol has been shown in this study to have a beneficial effect on ischemic injury in rats following a short-duration forebrain ischemic insult. + + However, it is important to note that while this finding does provide some evidence for mannitol as a potential treatment for injury in general, it does not necessarily mean that mannitol will be effective in all types of injuries or in human patients. The study was conducted in rats, not humans, and focused specifically on ischemic injury in the forebrain following short-duration insults. Additional studies would be needed to determine whether mannitol has similar effects in other injury models, species, and contexts before making any definitive conclusions about its therapeutic potential for treating injuries more broadly. + + Furthermore" +9454905,Mannitol treats ciguatera fish poisoning,1469,IV mannitol is considered the treatment of choice for CP but has not been evaluated in a double-blind randomized trial.,True,Is the triple 'Mannitol treats ciguatera fish poisoning' supported by the sentence: 'IV mannitol is considered the treatment of choice for CP but has not been evaluated in a double-blind randomized trial.'?,"Yes, while the statement does not explicitly confirm that mannitol treats ciguatera fish poisoning (CP), it does suggest that intravenous (IV) mannitol is considered the treatment of choice for CP based on current knowledge and understanding. The absence of a double-blind randomized trial does not necessarily disprove its effectiveness; however, it does indicate that there is a lack of rigorous clinical evidence supporting its use as a definitive treatment for CP. Nonetheless, without direct evidence refuting mannitol's efficacy in treating CP, one could infer indirect support for the initial claim based on expert consensus and its widespread use in clinical settings. However, further rigorous evaluation is needed for more conclusive evidence regarding mannitol's effectiveness in treating ciguatera fish poisoning." +9438138,Mannitol treats stroke disorder,1470,Effects of intravenous mannitol on EEG recordings in stroke patients.,False,Is the triple 'Mannitol treats stroke disorder' supported by the sentence: 'Effects of intravenous mannitol on EEG recordings in stroke patients.'?,"No, the statement ""Effects of intravenous mannitol on EEG recordings in stroke patients"" does not provide direct or indirect support for the claim that ""Mannitol treats stroke disorder"". This is because the provided statement only discusses the effects of mannitol on EEG recordings in stroke patients, which is an electrophysiological response rather than a clinical benefit or treatment for stroke disorder. + + In order for the statement to provide indirect support for treating stroke disorder, there should be some connection between mannitol affecting EEG recordings in stroke patients and an improvement in their condition. However, without additional information linking these two factors together, it is not possible to infer that mannitol has any therapeutic effect on stroke disorder based solely on its influence on EEG recordings. + + Furthermore, it is important to note that even if mannitol does have an effect on EEG recordings in stroke patients, it does not automatically imply that mannitol is treating stroke disorder; there could be other explanations for these observed effects that do not involve treatment efficacy. Therefore, further investigation is required before any definitive conclusions can be drawn regarding mannitol as a treatment for" +8850005,Mannitol treats coronary artery disorder,1471,"The data suggest the need to further evaluate the physiological importance of the increase in coronary blood flow produced by mannitol in patients with coronary artery disease and indicate the possibility that mannitol might be of value in treating certain problems in patients with coronary artery disease,",True,"Is the triple 'Mannitol treats coronary artery disorder' supported by the sentence: 'The data suggest the need to further evaluate the physiological importance of the increase in coronary blood flow produced by mannitol in patients with coronary artery disease and indicate the possibility that mannitol might be of value in treating certain problems in patients with coronary artery disease,'?","Yes, the statement does provide indirect support for the phrase ""Mannitol treats coronary artery disorder"". The passage suggests that mannitol increases coronary blood flow in patients with coronary artery disease, which implies it could have therapeutic potential in treating certain problems associated with this condition. However, it is important to note that while the statement supports mannitol's potential positive effects on coronary artery disease, it does not explicitly claim that mannitol treats the disorder itself; further investigation would be required for definitive evidence." +8674974,Mannitol treats bronchiectasis,1472,The 24-h effect of mannitol on the clearance of mucus in patients with bronchiectasis.,True,Is the triple 'Mannitol treats bronchiectasis' supported by the sentence: 'The 24-h effect of mannitol on the clearance of mucus in patients with bronchiectasis.'?,"Yes, the statement does provide indirect support for the phrase ""Mannitol treats bronchiectasis"". This is because it mentions that mannitol has an effect on mucus clearance in patients with bronchiectasis over 24 hours. Improved mucus clearance is one of the desired outcomes when treating bronchiectasis, as it can help alleviate symptoms and prevent further complications. Therefore, if mannitol is shown to enhance mucus clearance in patients with bronchiectasis, it could be considered as a potential treatment option for the disease. However, it is important to note that further investigation would be necessary to fully establish mannitol as an effective treatment for bronchiectasis, including clinical trials assessing its safety and efficacy compared to other available treatments." +8007841,"Mannitol treats chronic myelogenous leukemia, BCR-ABL1 positive",1473,Treatment of chronic myelocytic leukaemia with dibromo-mannitol (myelobromol).,False,"Is the triple 'Mannitol treats chronic myelogenous leukemia, BCR-ABL1 positive' supported by the sentence: 'Treatment of chronic myelocytic leukaemia with dibromo-mannitol (myelobromol).'?","No, the phrase ""Mannitol treats chronic myelogenous leukemia, BCR-ABL1 positive"" does not receive indirect support from the statement: ""Treatment of chronic myelocytic leukaemia with dibromo-mannitol (myelobromol)."" + + The statement mentions dibromo-mannitol (myelobromol), not mannitol alone. Dibromo-mannitol is a derivative of mannitol where bromine atoms have been added, significantly altering its chemical properties. Therefore, there is no implicit support for mannitol as a treatment for chronic myelogenous leukemia based on that statement alone." +7780960,Mannitol treats cystic fibrosis,1474,Inhaled mannitol is a potential mucoactive agent in cystic fibrosis patients.,True,Is the triple 'Mannitol treats cystic fibrosis' supported by the sentence: 'Inhaled mannitol is a potential mucoactive agent in cystic fibrosis patients.'?,"Yes, inhaled mannitol does receive indirect support as a potential treatment for cystic fibrosis based on the statement ""Inhaled mannitol is a potential mucoactive agent in cystic fibrosis patients."" + + The key term here is ""mucoactive agent,"" which refers to substances that can alter mucus properties. Mannitol has been shown in studies to have an impact on mucus clearance in cystic fibrosis patients by improving its hydration and reducing its viscosity. This could potentially alleviate some symptoms associated with cystic fibrosis such as persistent lung infections due to thick mucus buildup in airways. + + However, it is important to note that while this statement suggests mannitol may be beneficial for cystic fibrosis patients, it does not necessarily confirm that mannitol ""treats"" cystic fibrosis since treatment typically refers to managing or curing the underlying disease condition itself. Further studies would be needed to establish whether mannitol can indeed serve as a disease-modifying treatment for cystic fibrosis beyond its established role as a symptomatic therapy for improving" +7352141,Mannitol treats intracranial hypertension,1475,"CONCLUSION: Hypertonic saline, in both 3 and 23.4% concentrations, is as effective as mannitol in the treatment of intracranial hypertension observed in association with ICH.",True,"Is the triple 'Mannitol treats intracranial hypertension' supported by the sentence: 'CONCLUSION: Hypertonic saline, in both 3 and 23.4% concentrations, is as effective as mannitol in the treatment of intracranial hypertension observed in association with ICH.'?","Yes, indirectly it does support the claim that mannitol treats intracranial hypertension. The statement provided concludes that hypertonic saline is as effective as mannitol in treating intracranial hypertension associated with ICH (intracerebral hemorrhage). This implies that mannitol is indeed an effective treatment for intracranial hypertension. However, it does not necessarily mean that mannitol is superior to other treatments such as hypertonic saline nor does it provide direct evidence for mannitol's mechanism in treating intracranial hypertension." +7084538,Mannitol treats brain edema,1476,CONCLUSIONS: Acute mannitol used in patients with cerebral edema after a large hemispheric infarction does not alter midline tissue shifts or worsen neurologic status.,False,Is the triple 'Mannitol treats brain edema' supported by the sentence: 'CONCLUSIONS: Acute mannitol used in patients with cerebral edema after a large hemispheric infarction does not alter midline tissue shifts or worsen neurologic status.'?,"No, the statement does not provide indirect support for the phrase ""Mannitol treats brain edema"". In fact, it suggests that mannitol might not be effective in treating brain edema in certain situations. The conclusion states that using acute mannitol in patients with cerebral edema after a large hemispheric infarction does not alter midline tissue shifts or worsen neurologic status. This implies that mannitol may not improve conditions related to brain edema in these patients, which contradicts the idea that mannitol treats brain edema." +23769437,Temocillin treats bacterial infectious disease with sepsis,1477,The objective is to investigate if temocillin is non-inferior to carbapenems in the targeted treatment of bacteraemia due to 3GCR-E.,False,Is the triple 'Temocillin treats bacterial infectious disease with sepsis' supported by the sentence: 'The objective is to investigate if temocillin is non-inferior to carbapenems in the targeted treatment of bacteraemia due to 3GCR-E.'?,"No, the phrase ""Temocillin treats bacterial infectious disease with sepsis"" does not receive indirect support from the statement: ""The objective is to investigate if temocillin is non-inferior to carbapenems in the targeted treatment of bacteraemia due to 3GCR-E."" + + The statement provided is focused on comparing the efficacy of temocillin versus carbapenems in treating bacteraemia caused by 3GCR-E (third-generation cephalosporin-resistant Enterobacteriaceae). This investigation does not necessarily imply that temocillin treats bacterial infectious diseases associated with sepsis; it only suggests that temocillin could be an alternative treatment option for specific bacterial infections (those caused by 3GCR-E). + + Sepsis is a systemic inflammatory response syndrome caused by an infection, which can be initiated by various microorganisms (including bacteria, viruses, fungi) and not exclusively by 3GCR-E. Therefore, even if temocillin proves non-inferior in treating bacteraem" +17734631,Artesunic acid treats hepatocellular carcinoma,1478,CONCLUSION: These findings indicate that artesunate could offer a new approach to the therapy of hepatocellular carcinoma.,True,Is the triple 'Artesunic acid treats hepatocellular carcinoma' supported by the sentence: 'CONCLUSION: These findings indicate that artesunate could offer a new approach to the therapy of hepatocellular carcinoma.'?,"Yes, the statement ""CONCLUSION: These findings indicate that artesunate could offer a new approach to the therapy of hepatocellular carcinoma"" does provide indirect support for the phrase ""Artesunic acid treats hepatocellular carcinoma."" The conclusion suggests that artesunate (the sodium salt form of artesunic acid) has potential therapeutic effects on hepatocellular carcinoma based on certain findings. However, it is important to note that ""treats"" implies a direct clinical application, which may not be warranted based solely on this statement. Further investigation would be required to establish whether artesunic acid itself has therapeutic effects on hepatocellular carcinoma in clinical settings." +16415826,Artesunic acid treats Crohn disease,1479,Our data suggest a novel clinical application of artesunate as a potential therapy for Crohn's disease.,True,Is the triple 'Artesunic acid treats Crohn disease' supported by the sentence: 'Our data suggest a novel clinical application of artesunate as a potential therapy for Crohn's disease.'?,"Yes, the statement ""Our data suggest a novel clinical application of artesunate as a potential therapy for Crohn's disease"" does provide indirect support for the phrase ""Artesunic acid treats Crohn disease."" This is because it implies that artesunate has shown promise in treating Crohn's disease in a clinical context, which is consistent with the idea that artesunic acid could be an effective treatment for Crohn's disease. However, it is important to note that ""treats"" implies a more definitive effect than ""potential therapy,"" so while there is some support, it is not direct or definitive." +15681287,Artesunic acid treats breast neoplasm,1480,Taken together our in vitro and in vivo results correlate well showing for the first time that artesunate induces resistance in highly metastatic breast tumors.,False,Is the triple 'Artesunic acid treats breast neoplasm' supported by the sentence: 'Taken together our in vitro and in vivo results correlate well showing for the first time that artesunate induces resistance in highly metastatic breast tumors.'?,"No, the statement does not provide indirect support for the claim that artesunic acid treats breast neoplasm (breast cancer). In fact, it suggests quite the opposite: that artesunic acid may induce resistance in highly metastatic breast tumors. This could potentially lead to more aggressive cancer growth and poorer patient outcomes. Therefore, this statement does not support but rather contradicts the idea that artesunic acid could be an effective treatment for breast cancer." +13704055,Artesunic acid treats cytomegalovirus infection,1481,"This is the first report of treatment of cytomegalovirus infection with artesunate, for a stem cell transplant recipient with a newly identified foscarnet-resistant and ganciclovir-resistant DNA polymerase L776M mutation.",True,"Is the triple 'Artesunic acid treats cytomegalovirus infection' supported by the sentence: 'This is the first report of treatment of cytomegalovirus infection with artesunate, for a stem cell transplant recipient with a newly identified foscarnet-resistant and ganciclovir-resistant DNA polymerase L776M mutation.'?","Yes, indirectly it does lend some support. The statement provides evidence that artesunate was used successfully in treating a cytomegalovirus infection in a patient who had developed resistance to both foscarnet and ganciclovir, which are conventional treatments for such infections. However, it is important to note that this is only one case report and further studies would be needed to establish artesunic acid as an effective treatment for cytomegalovirus infection in general. Additionally, it should be noted that artesunic acid is not currently an approved treatment for cytomegalovirus infection by any major regulatory body such as the FDA in the United States. Therefore, while there is some support for the claim based on this report, it is far from definitive proof and further investigation is required before any definitive conclusions can be drawn." +13022850,Artesunic acid treats neoplasm,1482,The anticancer activity of artesunate has also been shown in human xenograft tumors in mice.,True,Is the triple 'Artesunic acid treats neoplasm' supported by the sentence: 'The anticancer activity of artesunate has also been shown in human xenograft tumors in mice.'?,"Yes, indirectly it does lend some support. The statement ""The anticancer activity of artesunate has also been shown in human xenograft tumors in mice"" suggests that artesunate, which is a derivative of artesunic acid, has demonstrated anticancer effects in preclinical studies using mouse models with human tumors (xenografts). This implies that artesunic acid might potentially have similar anticancer effects, though it is important to note that further investigation is required before making definitive conclusions about its clinical efficacy in treating neoplasms (abnormal tissue growths that can be benign or malignant). + + + + The distinction between artesunic acid and artesunate is crucial because artesunate is more soluble in water than artesunic acid, making it easier for therapeutic administration in clinical settings. The observed anticancer effects in mouse models do not automatically translate into equivalent effects in humans; however, they do provide promising leads for further exploration in clinical trials involving human patients. + + + + In summary, while the statement does not explicitly confirm that artesunic acid treats neoplasms, it" +10539481,Artesunic acid treats Fever,1483,The 2 groups that received artesunate experienced considerably more rapid reduction in parasitemia and in fever than the group that received only mefloquine (p.002).,False,Is the triple 'Artesunic acid treats Fever' supported by the sentence: 'The 2 groups that received artesunate experienced considerably more rapid reduction in parasitemia and in fever than the group that received only mefloquine (p.002).'?,"No, the statement does not provide direct support for the claim that artesunic acid treats fever. The provided statement is comparing artesunate (not artesunic acid) to mefloquine in terms of reducing parasitemia and fever in two groups receiving artesunate versus one group receiving mefloquine (p=0.002). Artesunate is a different compound from artesunic acid despite their shared derivation from Artemisia annua (sweet wormwood). Artesunic acid has not been mentioned in relation to fever reduction in this statement. Therefore, it is inappropriate to infer that artesunic acid treats fever based solely on this information." +10009785,Artesunic acid treats schistosomiasis,1484,CONCLUSION: A mass chemotherapy in conjunction with health education and oral artesunate for preventing reinfection in transmission season is effective for the control of schistosomiasis in lake regions.,True,Is the triple 'Artesunic acid treats schistosomiasis' supported by the sentence: 'CONCLUSION: A mass chemotherapy in conjunction with health education and oral artesunate for preventing reinfection in transmission season is effective for the control of schistosomiasis in lake regions.'?,"Yes, indirectly it does support that statement. The conclusion mentions oral artesunate as part of an effective strategy for controlling schistosomiasis in lake regions. Artesunic acid is a derivative of artesunate, which suggests that artesunic acid could also potentially play a role in treating schistosomiasis given its relationship with artesunate. However, it is important to note that the conclusion specifically mentions oral artesunate, not artesunic acid, so further investigation would be needed to definitively say that artesunic acid is an effective treatment for schistosomiasis based on this statement alone." +9194607,Artesunic acid treats urinary schistosomiasis,1485,"Artesunate and praziquantel for the treatment of Schistosoma haematobium infections: a double-blind, randomized, placebo-controlled study.",True,"Is the triple 'Artesunic acid treats urinary schistosomiasis' supported by the sentence: 'Artesunate and praziquantel for the treatment of Schistosoma haematobium infections: a double-blind, randomized, placebo-controlled study.'?","Yes, there is indirect support for the claim that artesunic acid treats urinary schistosomiasis based on the provided statement. The study mentions artesunate, which is derived from artesunic acid, as a treatment for Schistosoma haematobium infections, which can cause urinary schistosomiasis. However, it is important to note that artesunate was used in combination with praziquantel in the study, so further research would be needed to isolate the effects of artesunic acid specifically on urinary schistosomiasis." +7990355,Artesunic acid treats Plasmodium vivax malaria,1486,"To define the current efficacy of Fansidar (F. Hoffmann-La Roche Ltd., Basel Switzerland) (pyrimethamine and sulfadoxine), primaquine in a high dose, and artesunate for treating acute Plasmodium vivax malaria, we conducted a comparative clinical trial of these 3 drugs in an open-label study.",False,"Is the triple 'Artesunic acid treats Plasmodium vivax malaria' supported by the sentence: 'To define the current efficacy of Fansidar (F. Hoffmann-La Roche Ltd., Basel Switzerland) (pyrimethamine and sulfadoxine), primaquine in a high dose, and artesunate for treating acute Plasmodium vivax malaria, we conducted a comparative clinical trial of these 3 drugs in an open-label study.'?","No, the phrase ""Artesunic acid treats Plasmodium vivax malaria"" does not receive direct support from the statement provided. The statement describes a comparative clinical trial involving Fansidar (pyrimethamine and sulfadoxine), primaquine in a high dose, and artesunate for treating acute Plasmodium vivax malaria in an open-label study. However, it does not explicitly mention Artesunic acid being used in the trial nor does it report on its efficacy against Plasmodium vivax malaria. + + That said, one could argue that there is indirect support if the study found artesunate (which is similar in structure and mechanism to Artesunic acid) effective in treating Plasmodium vivax malaria. However, without explicit evidence regarding Artesunic acid itself, we cannot definitively say that it receives support from the statement provided." +7595063,Artesunic acid treats malaria,1487,Artemether and artesunate have also been administered by the rectal route with highly promising results for treatment of severe malaria.,True,Is the triple 'Artesunic acid treats malaria' supported by the sentence: 'Artemether and artesunate have also been administered by the rectal route with highly promising results for treatment of severe malaria.'?,"Yes, there is indirect support for the claim that artesunic acid treats malaria based on the provided statement. Artemether and artesunate are both derived from artemisinin, which is the active ingredient in artesunic acid. These compounds have demonstrated efficacy in treating severe malaria when administered via the rectal route. Therefore, it can be inferred that artemisinin-based treatments like artesunic acid could potentially treat malaria as well. However, it is important to note that direct clinical evidence specifically involving artesunic acid is not provided in the statement; hence, the support is indirect." +7113713,Artesunic acid treats Plasmodium falciparum malaria,1488,Declining concentrations of dihydroartemisinin in plasma during 5-day oral treatment with artesunate for Falciparum malaria.,False,Is the triple 'Artesunic acid treats Plasmodium falciparum malaria' supported by the sentence: 'Declining concentrations of dihydroartemisinin in plasma during 5-day oral treatment with artesunate for Falciparum malaria.'?,"No, the statement does not provide direct or indirect support for the claim that artesunic acid treats Plasmodium falciparum malaria. The statement discusses declining concentrations of dihydroartemisinin in plasma during 5-day oral treatment with artesunate for Falciparum malaria. Artesunate is a medication that is metabolized into dihydroartemisinin in the body. The decreasing concentrations of dihydroartemisinin in plasma could be attributed to various factors such as metabolism rate changes, dosage adjustments, or individual variability in drug response rather than an indication that artesunic acid is effective in treating Plasmodium falciparum malaria. + + Artesunic acid is structurally similar but distinct from artesunate; they both belong to the artemisinin class of antimalarial drugs derived from Artemisia annua (sweet wormwood). While artesunate has been proven effective in treating malaria caused by Plasmodium falciparum, there is no direct evidence presented in the statement that artesunic acid shares these therapeutic properties." +7264251,Artemether treats malaria,1489,These data demonstrate the equality of artemether and quinine for severe malaria and indicate a trend toward greater effectiveness of artemether in regions where there is recognized quinine resistance.,True,Is the triple 'Artemether treats malaria' supported by the sentence: 'These data demonstrate the equality of artemether and quinine for severe malaria and indicate a trend toward greater effectiveness of artemether in regions where there is recognized quinine resistance.'?,"Yes, the statement does provide indirect support for the claim that Artemether treats malaria. The key phrase here is ""greater effectiveness of artemether in regions where there is recognized quinine resistance."" This implies that Artemether is indeed effective against malaria, at least in areas where quinine resistance is prevalent. However, it doesn't directly state that Artemether treats malaria in all cases or regions, hence the indirect support. + + The statement also mentions a comparison between Artemether and Quinine, both of which are antimalarial drugs. The comparison suggests that Artemether is as effective as Quinine in treating severe malaria, and potentially more effective in certain regions due to quinine resistance. This further strengthens the inference that Artemether is an effective treatment for malaria. + + However, it's important to note that while this statement provides some evidence for the effectiveness of Artemether in treating malaria, it doesn't cover all aspects of its use, such as potential side effects, dosage, or its effectiveness against different strains of malaria. Therefore, while the statement does provide some support for the claim that Artemether" +7168046,Artemether treats Plasmodium falciparum malaria,1490,"The spectrum of falciparum malaria treatment has recently broadened to include new drugs such as artemisinin, artemether or atovaquone/proguanil, the latter being as yet unauthorized in France.",True,"Is the triple 'Artemether treats Plasmodium falciparum malaria' supported by the sentence: 'The spectrum of falciparum malaria treatment has recently broadened to include new drugs such as artemisinin, artemether or atovaquone/proguanil, the latter being as yet unauthorized in France.'?","Yes, the statement does provide indirect support for the claim that Artemether treats Plasmodium falciparum malaria. The statement mentions Artemether as one of the new drugs that have broadened the spectrum of falciparum malaria treatment. This implies that Artemether is indeed used in treating Plasmodium falciparum malaria, although it does not provide direct clinical trial results or mechanistic details. However, it is important to note that while Artemether is an effective antimalarial drug, it is typically used in combination therapy due to the emergence of drug-resistant strains of Plasmodium falciparum." +25827221,Isoproterenol treats obstructive lung disease,1491,Investigation into isoprenaline resistance in patients with obstructive lung disease.,False,Is the triple 'Isoproterenol treats obstructive lung disease' supported by the sentence: 'Investigation into isoprenaline resistance in patients with obstructive lung disease.'?,"No, the statement ""Investigation into isoprenaline resistance in patients with obstructive lung disease"" does not provide direct or indirect support for the claim that ""Isoproterenol treats obstructive lung disease."" + + Isoproterenol is also known as isoprenaline in some regions. While this investigation may involve studying isoproterenol resistance in patients with obstructive lung disease, it does not necessarily imply that isoproterenol is used as a treatment for the disease. In fact, it could suggest that isoproterenol is part of the problem (i.e., contributing to resistance). Therefore, without additional information linking isoproterenol use as a treatment for obstructive lung disease in this context, it is not appropriate to infer support for that claim." +15441635,Isoproterenol treats lipoma,1492,AIM: The aim of this study was to evaluate the efficacy of isoproterenol and prednisolone in the treatment of subcutaneous lipomas.,True,Is the triple 'Isoproterenol treats lipoma' supported by the sentence: 'AIM: The aim of this study was to evaluate the efficacy of isoproterenol and prednisolone in the treatment of subcutaneous lipomas.'?,"Yes, the phrase ""Isoproterenol treats lipoma"" does receive indirect support from the statement provided. The statement indicates that the aim of the study was to evaluate the efficacy of isoproterenol in the treatment of subcutaneous lipomas. This implies that isoproterenol is being used as a treatment for lipomas in this study, which aligns with the phrase ""Isoproterenol treats lipoma"". However, it is important to note that direct support would require more specific information about the outcomes of the study and whether isoproterenol was found to be effective in treating lipomas." +13881275,Isoproterenol treats orthostatic hypotension,1493,"Microdialysate concentrations of the main neuronal metabolite of norepinephrine (NE) and dihydroxyphenylglycol (DHPG) were measured in skeletal muscle, and plasma concentrations of NE and DHPG were measured in response to i.v. tyramine, yohimbine, and isoproterenol, in patients with PD+NOH, patients with pure autonomic failure (PAF), which is characterized by generalized catecholaminergic denervation, and control subjects.",False,"Is the triple 'Isoproterenol treats orthostatic hypotension' supported by the sentence: 'Microdialysate concentrations of the main neuronal metabolite of norepinephrine (NE) and dihydroxyphenylglycol (DHPG) were measured in skeletal muscle, and plasma concentrations of NE and DHPG were measured in response to i.v. tyramine, yohimbine, and isoproterenol, in patients with PD+NOH, patients with pure autonomic failure (PAF), which is characterized by generalized catecholaminergic denervation, and control subjects.'?","No, the statement does not provide direct support for the claim that ""Isoproterenol treats orthostatic hypotension"". The study measures concentrations of certain metabolites in response to various substances including isoproterenol in different groups of patients but does not explicitly evaluate its effectiveness in treating orthostatic hypotension. Therefore, while it may provide indirect evidence if interpreted in conjunction with other studies showing such an effect, it does not directly support the claim on its own." +11481186,Isoproterenol treats atrial fibrillation,1494,"RESULTS: LAP series analysis shows a reduction of both LP and R index during isoproterenol infusion in SR and AF (RSR = 0.75 +/- 0.07 RSRISO = 0.69 +/- 0.10, p < 0.0001; RAF = 0.31 +/- 0.08 RAFISO = 0.26 +/- 0.09, p < 0.0001; LPSR = 99.99 +/- 0.001 LPSRISO = 99.97 +/- 0.03, p < 0.0001; LPAF = 69.46 +/- 21.55 LPAFISO = 55 +/- 24.75; p < 0.0001).",False,"Is the triple 'Isoproterenol treats atrial fibrillation' supported by the sentence: 'RESULTS: LAP series analysis shows a reduction of both LP and R index during isoproterenol infusion in SR and AF (RSR = 0.75 +/- 0.07 RSRISO = 0.69 +/- 0.10, p < 0.0001; RAF = 0.31 +/- 0.08 RAFISO = 0.26 +/- 0.09, p < 0.0001; LPSR = 99.99 +/- 0.001 LPSRISO = 99.97 +/- 0.03, p < 0.0001; LPAF = 69.46 +/- 21.55 LPAFISO = 55 +/- 24.75; p < 0.0001).'?","No, the statement does not provide direct support for the claim that ""Isoproterenol treats atrial fibrillation."" However, it does offer indirect evidence suggesting that isoproterenol may have an effect on atrial fibrillation (AF) based on changes in certain indices (LP, R) during isoproterenol infusion in both sinus rhythm (SR) and AF states. + + The statement reports results from a study using isoproterenol infusion in SR and AF states while measuring changes in LP and R indices (LPSR, LPAF, RSR, RAF). The results show that there is a statistically significant" +9565866,Isoproterenol treats obesity disorder,1495,Decreased responsiveness to isoproterenol in obesity may be due to defects downstream of adenylyl cyclase activation of cyclic AMP.,False,Is the triple 'Isoproterenol treats obesity disorder' supported by the sentence: 'Decreased responsiveness to isoproterenol in obesity may be due to defects downstream of adenylyl cyclase activation of cyclic AMP.'?,"No, the statement does not provide indirect support for the phrase ""Isoproterenol treats obesity disorder"". The original statement suggests that obese individuals have decreased responsiveness to isoproterenol due to defects downstream of adenylyl cyclase activation of cyclic AMP. This implies that isoproterenol may not be effective in treating obesity because obese individuals do not respond well to it. Therefore, the statement seems to indicate that isoproterenol might not be an appropriate treatment for obesity disorder." +8710440,Isoproterenol treats postural orthostatic tachycardia syndrome,1496,the responses of heart rate and the plasma cyclic AMP (cAMP) level to isoproterenol infusion in the supine position were evaluated in 10 POTS patients and 10 age-matched controls.,True,Is the triple 'Isoproterenol treats postural orthostatic tachycardia syndrome' supported by the sentence: 'the responses of heart rate and the plasma cyclic AMP (cAMP) level to isoproterenol infusion in the supine position were evaluated in 10 POTS patients and 10 age-matched controls.'?,"Yes, indirectly it does lend some support. The statement mentions that isoproterenol infusion in the supine position was evaluated in terms of heart rate responses and plasma cyclic AMP (cAMP) level in both POTS patients and age-matched controls. This suggests that isoproterenol has been studied in relation to postural orthostatic tachycardia syndrome (POTS). However, it does not explicitly state that isoproterenol treats POTS; it only explores its effects on heart rate and cAMP levels in POTS patients. + + To make stronger conclusions about isoproterenol as a treatment for POTS, further information would be needed such as randomized controlled trials demonstrating its efficacy in treating POTS symptoms compared to placebo or other treatments. The current statement is limited in scope as it only presents a correlation between isoproterenol administration and physiological measurements in POTS patients without establishing causation or therapeutic benefits." +10687311,Metaproterenol treats obstructive lung disease,1497,ORCIPRENALINE IN TREATMENT OF AIRWAYS OBSTRUCTION IN CHRONIC BRONCHITIS.,True,Is the triple 'Metaproterenol treats obstructive lung disease' supported by the sentence: 'ORCIPRENALINE IN TREATMENT OF AIRWAYS OBSTRUCTION IN CHRONIC BRONCHITIS.'?,"Yes, there is indirect support for the claim that ""Metaproterenol treats obstructive lung disease"". This is based on the statement ""ORCIPRENALINE IN TREATMENT OF AIRWAYS OBSTRUCTION IN CHRONIC BRONCHITIS."" + + The reason behind this is that Orciprenaline (also known as Metaproterenol) is a medication used to treat conditions associated with obstructive lung disease, such as chronic bronchitis. Both Orciprenaline and Metaproterenol are short-acting beta-2 adrenergic agonists (SABAs) that help relax muscles in the airways and increase airflow to the lungs, making it easier to breathe. + + Although the statement does not explicitly mention Metaproterenol by name, it refers to Orciprenaline, which is pharmacologically equivalent to Metaproterenol. Therefore, it can be inferred that Metaproterenol does indeed have a role in treating obstructive lung disease, specifically in managing airways obstruction in chronic bronchitis. + + However, it is important to note" +21781034,Bacitracin A treats Infection,1498,"Based on these observations, the combination of CBD and BAC is suggested to be a putative novel treatment in clinical settings for treatment of infections with antibiotic resistant Gram-positive bacteria.",False,"Is the triple 'Bacitracin A treats Infection' supported by the sentence: 'Based on these observations, the combination of CBD and BAC is suggested to be a putative novel treatment in clinical settings for treatment of infections with antibiotic resistant Gram-positive bacteria.'?","No, the phrase ""Bacitracin A treats Infection"" does not receive direct support from the statement provided. The statement suggests that a combination therapy involving both CBD (cannabidiol) and BAC (Bacitracin A) may be an effective treatment for infections caused by antibiotic-resistant Gram-positive bacteria. However, it does not specifically indicate that Bacitracin A alone is sufficient for treating infections. Therefore, while Bacitracin A might be part of an effective treatment regimen when used in combination with CBD in specific cases as suggested by the statement, it does not provide direct evidence that Bacitracin A alone can treat infections." +17678351,Bacitracin A treats bacterial infectious disease,1499,"Thus, the bacitracin and gramicidin S-based self-assembled nanopeptide ribbon may be a successful ointment formulation for bacterial infection control.",True,"Is the triple 'Bacitracin A treats bacterial infectious disease' supported by the sentence: 'Thus, the bacitracin and gramicidin S-based self-assembled nanopeptide ribbon may be a successful ointment formulation for bacterial infection control.'?","Yes, indirectly it does lend some support. The statement mentions that bacitracin-based nanopeptide ribbon has potential as an ointment formulation for bacterial infection control. Bacitracin is known for its antibacterial properties which can be effective in treating bacterial infectious diseases. However, it is important to note that while bacitracin has antibacterial properties, it does not necessarily mean that it can treat all bacterial infectious diseases as there may be various factors such as bacterial resistance, severity of infection, etc., that can influence its effectiveness in treatment." +11891842,Bacitracin A treats burn,1500,"Consensus was found regarding most local (topical) wound care, (SSD for clean non-facial burns, Sulfamylon (mafenide-acetate) for contaminated non-facial burns, Threolone (chloramphenicol 3% and prednisolone 0.5%) or Bacitracin for facial burns, Paraffin gauzes with or without Sulfamylon for donor and graft sites).",True,"Is the triple 'Bacitracin A treats burn' supported by the sentence: 'Consensus was found regarding most local (topical) wound care, (SSD for clean non-facial burns, Sulfamylon (mafenide-acetate) for contaminated non-facial burns, Threolone (chloramphenicol 3% and prednisolone 0.5%) or Bacitracin for facial burns, Paraffin gauzes with or without Sulfamylon for donor and graft sites).'?","Yes, the statement does provide indirect support for the claim that Bacitracin A treats burns, specifically facial burns. The consensus statement includes Bacitracin as an option for local wound care in facial burns, suggesting its appropriateness in such situations due to its inclusion in expert opinion. However, it is crucial to note that correlation does not imply causation; therefore, while Bacitracin is recommended for facial burns, it does not necessarily mean it is the active treatment agent causing improvement in burns. Other factors such as wound care best practices may contribute significantly to burn healing." +26452786,Fenbendazole causes helminthiasis,101,The anti-ischemic mechanism of action of ranolazine in stable ischemic heart disease.,False,Is the triple 'Fenbendazole causes helminthiasis' supported by the sentence: 'The anti-ischemic mechanism of action of ranolazine in stable ischemic heart disease.'?,"No, the statement ""The anti-ischemic mechanism of action of ranolazine in stable ischemic heart disease"" does not provide any indirect support for the claim ""Fenbendazole causes helminthiasis."" These two statements discuss entirely different subjects: one is about a medication used for treating ischemic heart disease (ranolazine), while the other pertains to an anthelmintic drug (fenbendazole) possibly causing helminthiasis (a helminth infection). Thus, there is no logical connection between these two statements that would allow one to indirectly support the other." +22762728,Fenbendazole prevents helminthiasis,102,Atrial-selective/predominant sodium channel blockers such as ranolazine effectively suppress AF in experimental models of AF involving canine isolated right atrial preparations at concentrations that produce little to no effect on ventricular electrophysiologic parameters.,False,Is the triple 'Fenbendazole prevents helminthiasis' supported by the sentence: 'Atrial-selective/predominant sodium channel blockers such as ranolazine effectively suppress AF in experimental models of AF involving canine isolated right atrial preparations at concentrations that produce little to no effect on ventricular electrophysiologic parameters.'?,"No, the statement does not provide any direct or indirect support for the claim that Fenbendazole prevents helminthiasis. + + The statement discusses the effects of atrial-selective/predominant sodium channel blockers, specifically ranolazine, on atrial fibrillation (AF) in canine isolated right atrial preparations. It does not mention Fenbendazole or helminthiasis at all. + + Helminthiasis is a condition characterized by infection with parasitic worms, which Fenbendazole is known to treat. However, there is no connection made in the statement between Fenbendazole and helminthiasis prevention, nor between ranolazine, AF, and potential anti-parasitic effects that could indirectly support the claim about Fenbendazole. + + To establish support for the claim about Fenbendazole preventing helminthiasis, one would need evidence specifically pertaining to Fenbendazole's effectiveness in preventing or treating helminthiasis in appropriate models or clinical settings." +21848143,Albendazole causes helminthiasis,103,Ranolazine has been shown to decrease angina pectoris frequency and nitroglycerin consumption.,False,Is the triple 'Albendazole causes helminthiasis' supported by the sentence: 'Ranolazine has been shown to decrease angina pectoris frequency and nitroglycerin consumption.'?,"No, the statement ""Ranolazine has been shown to decrease angina pectoris frequency and nitroglycerin consumption"" does not provide any indirect support for the claim that ""Albendazole causes helminthiasis."" These two statements discuss unrelated subjects: one is about a medication used to treat angina pectoris (ranolazine) while the other is about an anti-parasitic drug (albendazole) that can potentially cause helminthiasis as an adverse effect in rare cases. The statements come from different areas in medical science - cardiology and parasitology respectively - without any overlap in their implications." +25735916,Albendazole affects trichuriasis,104,BACKGROUND: Ranolazine has been shown to reduce myocardial ischemia and symptom severity among selected patients with chronic angina.,False,Is the triple 'Albendazole affects trichuriasis' supported by the sentence: 'BACKGROUND: Ranolazine has been shown to reduce myocardial ischemia and symptom severity among selected patients with chronic angina.'?,"No, the statement does not provide indirect support for the phrase ""Albendazole affects trichuriasis."" The background statement discusses Ranolazine, its effects on myocardial ischemia, and its impact on symptom severity in certain patients with chronic angina. This information is unrelated to Albendazole, which is an anthelmintic drug used for treating parasitic worm infections such as trichuriasis. Therefore, it does not offer any indirect evidence or support for the claim that Albendazole affects trichuriasis." +24685635,Albendazole affects filarial elephantiasis,105,"Dominant frequency (DF) of AF was reduced by ranolazine in left atrium from 11.7 (10.7-20.5) Hz to 7.6 (2.9-8.8) Hz (P = 0.02, n = 6).",False,"Is the triple 'Albendazole affects filarial elephantiasis' supported by the sentence: 'Dominant frequency (DF) of AF was reduced by ranolazine in left atrium from 11.7 (10.7-20.5) Hz to 7.6 (2.9-8.8) Hz (P = 0.02, n = 6).'?","No, the statement does not provide any direct or indirect support for the phrase ""Albendazole affects filarial elephantiasis"". The statement discusses the effect of ranolazine on the dominant frequency (DF) of atrial fibrillation (AF) in humans, whereas albendazole is an antiparasitic drug used primarily for treating soil-transmitted helminthiases (intestinal worm infections) and filarial diseases such as lymphatic filariasis (elephantiasis). The two statements discuss different drugs, diseases, and experimental setups; hence there is no connection between them to infer support for the original phrase." +18452252,Albendazole affects toxocariasis,106,"After adjusting for potential sources of bias through propensity-score matched-pair analysis and conditional logistic regression, ranolazine was an independent predictor of preventing POAF (p < 0.0001).",False,"Is the triple 'Albendazole affects toxocariasis' supported by the sentence: 'After adjusting for potential sources of bias through propensity-score matched-pair analysis and conditional logistic regression, ranolazine was an independent predictor of preventing POAF (p < 0.0001).'?","No, the statement does not provide any direct or indirect support for the phrase ""Albendazole affects toxocariasis"". The two statements discuss different topics: ranolazine's effect on preventing postoperative atrial fibrillation (POAF) in one case and albendazole's effect on toxocariasis in another case. The methods used in the study on ranolazine do not relate to albendazole or its effects on toxocariasis. + + + To further elaborate on why there is no indirect support between these two statements: + + 1) Different drugs: Ranolazine is not related to albendazole in terms of chemical structure or therapeutic class; therefore, any conclusions drawn from one drug would not necessarily apply to another drug without additional evidence supporting such an association. + + 2) Different conditions: The study focuses on ranolazine preventing POAF in patients undergoing cardiac surgery while albendazole is used for treating parasitic infections such as toxocariasis; hence, there is no clear link between these two medical conditions that would allow for indirect inferences based on these statements alone." +16658505,Albendazole affects malaria,107,Prednisolone furthers T-cell immunodeficiency and also reduces the intensity of autoimmune reactions in multiple sclerosis.,False,Is the triple 'Albendazole affects malaria' supported by the sentence: 'Prednisolone furthers T-cell immunodeficiency and also reduces the intensity of autoimmune reactions in multiple sclerosis.'?,"No, the statement does not provide indirect support for the phrase ""Albendazole affects malaria."" The two statements discuss different drugs (Albendazole vs Prednisolone) and their respective effects on unrelated conditions (malaria vs T-cell immunodeficiency and autoimmune reactions in multiple sclerosis). There is no connection between these two distinct pharmacological agents and their effects on separate health issues that would allow for indirect inference regarding Albendazole's impact on malaria." +13946207,Albendazole affects helminthiasis,108,[Pharmacokinetics of prednisolone in adrenal insufficiency ].,False,Is the triple 'Albendazole affects helminthiasis' supported by the sentence: '[Pharmacokinetics of prednisolone in adrenal insufficiency ].'?,"No, the statement ""Pharmacokinetics of prednisolone in adrenal insufficiency"" does not provide any direct or indirect support for the phrase ""Albendazole affects helminthiasis."" The two statements discuss different topics: one is about pharmacokinetics (the process in which a drug is absorbed, distributed, metabolized, and excreted) of prednisolone in adrenal insufficiency, while the other refers to albendazole's effect on helminthiasis (a parasitic infection caused by helminths). + + To further elaborate on my response, let me provide some context for both concepts: + + 1. Pharmacokinetics: This term refers to how an organism handles a drug in terms of absorption, distribution, metabolism, and excretion (ADME). The statement in question refers specifically to prednisolone in adrenal insufficiency; however, it does not provide any information about albendazole or helminthiasis that would support their connection. + + 2. Albendazole affects helminthiasis: Albend" +11239060,Albendazole affects filariasis,109,It is concluded that VAP is effective therapy in AIL.,False,Is the triple 'Albendazole affects filariasis' supported by the sentence: 'It is concluded that VAP is effective therapy in AIL.'?,"No, the statement ""It is concluded that VAP is effective therapy in AIL"" does not provide indirect support for the phrase ""Albendazole affects filariasis."" + + The conclusion that VAP (presumably referring to a specific treatment regimen) is effective therapy in AIL (Adult Intestinal Loiasis) does not necessarily imply any connection to albendazole or its effects on filariasis. Filariasis is a parasitic disease caused by nematode worms, while Loiasis is caused by another species of nematode worm. Although both conditions can be treated with various anthelmintic drugs (including albendazole), they represent distinct clinical entities. + + Therefore, without additional information linking albendazole, filariasis, and VAP in AIL treatment, it is not possible to infer any supportive relationship between the two statements provided." +24729219,Albendazole disrupts helminthiasis,110,A thermographic assessment of three intra-articular prednisolone analogues given in rheumatoid synovitis.,False,Is the triple 'Albendazole disrupts helminthiasis' supported by the sentence: 'A thermographic assessment of three intra-articular prednisolone analogues given in rheumatoid synovitis.'?,"No, the statement ""A thermographic assessment of three intra-articular prednisolone analogues given in rheumatoid synovitis"" does not provide indirect support for the phrase ""Albendazole disrupts helminthiasis."" + + The statement is about a thermographic assessment of three intra-articular prednisolone analogues in rheumatoid synovitis, which is an evaluation of arthritis treatment methods using thermal imaging. This has no direct relation to albendazole, which is an antiparasitic medication used primarily for treating intestinal worm infections (helminthiasis). The two statements belong to different medical fields (rheumatology and parasitology respectively) without any overlap in their subject matter or implications." +16658503,Albendazole disrupts malaria,111,The effect of small doses of prednisolone on the incidence of subcutaneous sarcomas induced by 3-methylcholanthrene in virgin female Swiss mice.,False,Is the triple 'Albendazole disrupts malaria' supported by the sentence: 'The effect of small doses of prednisolone on the incidence of subcutaneous sarcomas induced by 3-methylcholanthrene in virgin female Swiss mice.'?,"No, the statement does not provide any indirect support for the phrase ""Albendazole disrupts malaria."" The statement discusses the effect of small doses of prednisolone on subcutaneous sarcomas induced by 3-methylcholanthrene in female Swiss mice. This has no relation to albendazole or malaria." +13637338,Albendazole disrupts Hookworm Infections,112,[Effects of chromocarb diethylamine and prednisolone in experimental uveitis induced by clove oil in rabbits].,False,Is the triple 'Albendazole disrupts Hookworm Infections' supported by the sentence: '[Effects of chromocarb diethylamine and prednisolone in experimental uveitis induced by clove oil in rabbits].'?,"No, the statement does not provide indirect support for the phrase ""Albendazole disrupts Hookworm Infections."" The title in question discusses the effects of chromocarb diethylamine and prednisolone in experimental uveitis induced by clove oil in rabbits. There is no mention or implication of albendazole, hookworm infections, or any related biological processes in this title. Therefore, it does not offer any relevant context or evidence that could indirectly support the claim about albendazole disrupting hookworm infections." +15248433,Albendazole prevents filariasis,113,[Effect of prednisolone and heparin on circulating T- and B-lymphocytes in glomerulonephritis and systemic lupus erythematosus].,False,Is the triple 'Albendazole prevents filariasis' supported by the sentence: '[Effect of prednisolone and heparin on circulating T- and B-lymphocytes in glomerulonephritis and systemic lupus erythematosus].'?,"No, the statement does not provide any direct or indirect support for the claim that Albendazole prevents filariasis. The provided statement discusses the effect of prednisolone and heparin on circulating T- and B-lymphocytes in glomerulonephritis and systemic lupus erythematosus, which is unrelated to Albendazole or filariasis prevention. + + To further clarify, filariasis is caused by parasitic roundworms that belong to the Filarioidea family; it is not related to glomerulonephritis (inflammation in kidney) or systemic lupus erythematosus (autoimmune disorder). Albendazole is an anthelmintic drug used in treating filariasis; however, it is not mentioned in the given statement at all. + + In conclusion, there is no connection between the statement provided and the claim that Albendazole prevents filariasis, making it invalid to infer any level of support from one to another." +13732336,Albendazole prevents helminthiasis,114,[Effects of prednisolone on thyroidal-123I uptake in subacute thyroiditis].,False,Is the triple 'Albendazole prevents helminthiasis' supported by the sentence: '[Effects of prednisolone on thyroidal-123I uptake in subacute thyroiditis].'?,"No, the statement does not provide any direct or indirect support for the claim that Albendazole prevents helminthiasis. The statement is about prednisolone's effects on thyroidal-123I uptake in subacute thyroiditis, which is unrelated to Albendazole or helminthiasis. Helminthiasis is a condition caused by parasitic worms, and Albendazole is an anti-parasitic drug used to treat such conditions. However, there is no mention or implication of this in the provided statement." +15316470,Ibuprofen subclass of 2-Hydroxyibuprofen,115,"Blood Eosinophil Depletion with Mepolizumab, Benralizumab and Prednisolone in Eosinophilic Asthma.",False,"Is the triple 'Ibuprofen subclass of 2-Hydroxyibuprofen' supported by the sentence: 'Blood Eosinophil Depletion with Mepolizumab, Benralizumab and Prednisolone in Eosinophilic Asthma.'?","No, the phrase ""Ibuprofen subclass of 2-Hydroxyibuprofen"" does not receive indirect support from the statement: ""Blood Eosinophil Depletion with Mepolizumab, Benralizumab and Prednisolone in Eosinophilic Asthma."" + + The statement provided primarily discusses blood eosinophil depletion in eosinophilic asthma using three specific medications: mepolizumab, benralizumab, and prednisolone. Ibuprofen is not mentioned in the statement nor is it related to any of these medications in terms of being a subclass. + + Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) that is commonly used for pain relief and fever reduction. 2-Hydroxyibuprofen is one of the major metabolites formed in vivo when ibuprofen is metabolized in humans by cytochrome P450 enzymes (primarily CYP2C9). Thus, 2-Hydroxyibuprofen is not" +16265626,Ibuprofen related to Arthralgia,116,[Prednisolone and aspirin combination therapy in habitual abortion with autoantibodies].,False,Is the triple 'Ibuprofen related to Arthralgia' supported by the sentence: '[Prednisolone and aspirin combination therapy in habitual abortion with autoantibodies].'?,"No, the statement ""Prednisolone and aspirin combination therapy in habitual abortion with autoantibodies"" does not provide indirect support for the phrase ""Ibuprofen related to Arthralgia."" The statement discusses prednisolone and aspirin combination therapy in relation to habitual abortion in patients who have autoantibodies, which does not mention ibuprofen or arthralgia (joint pain). + + The statement does discuss aspirin, which is another non-steroidal anti-inflammatory drug (NSAID) like ibuprofen; however, it does not provide evidence for an association between ibuprofen specifically and arthralgia. + + It is essential not to make unwarranted conclusions based on insufficient evidence in order to maintain integrity in interpreting research results." +14582794,Ibuprofen related to Pain,117,"To illustrate this, we used an example of cost-effectiveness analysis for docetaxel in combination with prednisolone in metastatic hormone-refractory prostate cancer.",False,"Is the triple 'Ibuprofen related to Pain' supported by the sentence: 'To illustrate this, we used an example of cost-effectiveness analysis for docetaxel in combination with prednisolone in metastatic hormone-refractory prostate cancer.'?","No, the statement does not provide any direct or indirect support for the phrase ""Ibuprofen related to Pain."" The statement discusses a cost-effectiveness analysis for docetaxel in combination with prednisolone in metastatic hormone-refractory prostate cancer. Ibuprofen, which is a non-steroidal anti-inflammatory drug (NSAID) used primarily for relieving pain, inflammation, and fever, is not mentioned in the statement. Therefore, there is no connection between ibuprofen and pain in this context." +11440746,Ibuprofen related to Toothache,118,Prednisolone is associated with a worse bone mineral density in primary adrenal insufficiency.,False,Is the triple 'Ibuprofen related to Toothache' supported by the sentence: 'Prednisolone is associated with a worse bone mineral density in primary adrenal insufficiency.'?,"No, the statement ""Prednisolone is associated with worse bone mineral density in primary adrenal insufficiency"" does not provide indirect support for the phrase ""Ibuprofen related to Toothache."" These two statements discuss different subjects (Prednisolone and bone mineral density vs Ibuprofen and toothache) and do not share any common concepts that would allow for an indirect inference between them. + + However, Ibuprofen is an NSAID (nonsteroidal anti-inflammatory drug) like aspirin and naproxen, which can be used for pain relief including toothaches. Prednisolone is a corticosteroid used primarily for its anti-inflammatory effects in various conditions such as adrenal insufficiency. Although both types of medications have anti-inflammatory properties, they have different mechanisms of action; thus, their effects on the body can vary significantly. + + Therefore, it is crucial to assess each medication individually based on relevant studies and evidence when discussing their associations with specific health issues such as toothache or bone mineral density changes." +9106384,Ibuprofen related to osteoarthritis,119,CONCLUSIONS: Prednisolone was more effective in inducing response than itraconazole in acute-stage ABPA.,False,Is the triple 'Ibuprofen related to osteoarthritis' supported by the sentence: 'CONCLUSIONS: Prednisolone was more effective in inducing response than itraconazole in acute-stage ABPA.'?,"No, the statement ""Prednisolone was more effective in inducing response than itraconazole in acute-stage ABPA"" does not provide indirect support for the phrase ""Ibuprofen related to osteoarthritis."" The conclusion is about the efficacy comparison between prednisolone and itraconazole for treating acute-stage allergic bronchopulmonary aspergillosis (ABPA). Ibuprofen is not mentioned in the statement, nor is there any connection made between ibuprofen and osteoarthritis in it. + + To provide indirect support for ""Ibuprofen related to osteoarthritis,"" one should find evidence that links ibuprofen usage in treating osteoarthritis symptoms or side effects in patients suffering from osteoarthritis. This statement does not offer any such connection, so it cannot be used as indirect evidence for that claim." +8106985,Ibuprofen related to burn,120,"Purpose: The aim of this study was to compare asparaginase-related toxicities in two asparaginase preparations, namely native Escherichia coli L-asparaginase (L-ASP) and pegylated asparaginase (PEG-ASP) in combination with ifosfamide, methotrexate, etoposide, and prednisolone (IMEP) in natural killer (NK)/T-cell lymphoma (NTCL).",False,"Is the triple 'Ibuprofen related to burn' supported by the sentence: 'Purpose: The aim of this study was to compare asparaginase-related toxicities in two asparaginase preparations, namely native Escherichia coli L-asparaginase (L-ASP) and pegylated asparaginase (PEG-ASP) in combination with ifosfamide, methotrexate, etoposide, and prednisolone (IMEP) in natural killer (NK)/T-cell lymphoma (NTCL).'?","No, the statement does not provide any indirect support for the phrase ""Ibuprofen related to burn"". The purpose statement discusses a study comparing toxicities from two asparaginase preparations used in combination therapy for NK/T-cell lymphoma. Ibuprofen is not mentioned in the statement, nor is there any connection made between ibuprofen and burn-related injuries." +13726345,Ibuprofen causes patent ductus arteriosus,121,Prednisolone combined with adjunctive immunosuppression is not superior to prednisolone alone in terms of efficacy and safety in giant cell arteritis: meta-analysis.,False,Is the triple 'Ibuprofen causes patent ductus arteriosus' supported by the sentence: 'Prednisolone combined with adjunctive immunosuppression is not superior to prednisolone alone in terms of efficacy and safety in giant cell arteritis: meta-analysis.'?,"No, the statement does not provide indirect support for the phrase ""Ibuprofen causes patent ductus arteriosus"". The meta-analysis discusses the efficacy and safety of prednisolone combined with adjunctive immunosuppression versus prednisolone alone in treating giant cell arteritis, without mentioning ibuprofen or patent ductus arteriosus. + + The two statements belong to different medical contexts: one is about ibuprofen potentially causing patent ductus arteriosus (PDA), while another is about prednisolone treatment in giant cell arteritis (GCA). There is no overlap between these subjects in terms of pharmacological agents discussed (ibuprofen vs prednisolone) or medical conditions addressed (PDA vs GCA). Therefore, it is inappropriate to infer indirect support from one statement for the claim made in another statement. + + In summary, no indirect support exists between these two statements due to their unrelated subject matter. The misinterpretation could lead to incorrect conclusions drawn from unrelated evidence, emphasizing the need for careful examination when interpreting scientific statements in context." +13653982,Ibuprofen causes Alzheimer disease,122,CONCLUSION: GVP is well-tolerated regimen with high response rate and needs to be tested in late relapsed HL.,False,Is the triple 'Ibuprofen causes Alzheimer disease' supported by the sentence: 'CONCLUSION: GVP is well-tolerated regimen with high response rate and needs to be tested in late relapsed HL.'?,"No, the statement ""Ibuprofen causes Alzheimer disease"" does not receive any direct or indirect support from the conclusion ""GVP is well-tolerated regimen with high response rate and needs to be tested in late relapsed HL."" + + The conclusion is about a treatment regimen (GVP) for late relapsed Hodgkin Lymphoma (HL) and its tolerability and response rate. Ibuprofen is not mentioned in the conclusion, nor is there any connection made between ibuprofen and Alzheimer disease. Therefore, there is no basis for such an inference in this context." +13133316,Ibuprofen causes peptic ulcer disease,123,Early treatment with addition of low dose prednisolone to methotrexate improves therapeutic outcome in severe psoriatic arthritis.,False,Is the triple 'Ibuprofen causes peptic ulcer disease' supported by the sentence: 'Early treatment with addition of low dose prednisolone to methotrexate improves therapeutic outcome in severe psoriatic arthritis.'?,"No, the statement ""Early treatment with addition of low dose prednisolone to methotrexate improves therapeutic outcome in severe psoriatic arthritis"" does not provide indirect support for the claim that ""Ibuprofen causes peptic ulcer disease."" + + The two statements discuss different subjects: one is about a treatment regimen for psoriatic arthritis, while the other is about ibuprofen potentially causing peptic ulcer disease. The first statement does not mention ibuprofen nor imply any connection between ibuprofen use and peptic ulcer disease risk; therefore, it does not provide any indirect support for that claim. + + Peptic ulcer disease is an adverse effect associated with nonsteroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen; however, multiple factors can contribute to its development, including bacterial infections (e.g., Helicobacter pylori) and genetic predispositions. It is essential to maintain clear lines of evidence when interpreting statements in order to avoid misleading conclusions based on unrelated information." +12641386,Ibuprofen causes Fever,124,"CONCLUSION: Flu/Cy/ATG conditioning regimen, bone marrow as stem cell source and CSA, prednisolone and short methotrexate regimen were associated with better survival in AA.",False,"Is the triple 'Ibuprofen causes Fever' supported by the sentence: 'CONCLUSION: Flu/Cy/ATG conditioning regimen, bone marrow as stem cell source and CSA, prednisolone and short methotrexate regimen were associated with better survival in AA.'?","No, the phrase ""Ibuprofen causes fever"" does not receive any support from the statement provided. The conclusion mentioned refers to a study on allogeneic hematopoietic stem cell transplantation (HSCT) in patients with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS). It discusses various conditioning regimens and their impact on survival rates but does not mention ibuprofen or fever at all. Ibuprofen is an analgesic and anti-inflammatory drug, and it is not typically associated with causing fever; on the contrary, it is often used to reduce fever. Therefore, there is no indirect support for the claim that ibuprofen causes fever in this statement." +12482174,Ibuprofen causes pancreatitis,125,Effect of addition of short course of prednisolone to gluten-free diet on mucosal epithelial cell regeneration and apoptosis in celiac disease: a pilot randomized controlled trial.,False,Is the triple 'Ibuprofen causes pancreatitis' supported by the sentence: 'Effect of addition of short course of prednisolone to gluten-free diet on mucosal epithelial cell regeneration and apoptosis in celiac disease: a pilot randomized controlled trial.'?,"No, the statement does not provide any direct or indirect support for the claim that ibuprofen causes pancreatitis. The study mentioned is focused on examining the effect of adding a short course of prednisolone to a gluten-free diet on mucosal epithelial cell regeneration and apoptosis in celiac disease participants as part of a pilot randomized controlled trial. + + The study does not involve ibuprofen use nor investigate its potential link to pancreatitis. In order to make an informed decision about whether ibuprofen causes pancreatitis, one should consult other relevant studies that specifically investigate ibuprofen use and its potential association with pancreatitis development." +12438812,Ibuprofen causes Toothache,126,Coadministration of cyclosporin a with prednisolone in acute interstitial pneumonia complicating polymyositis/dermatomyositis.,False,Is the triple 'Ibuprofen causes Toothache' supported by the sentence: 'Coadministration of cyclosporin a with prednisolone in acute interstitial pneumonia complicating polymyositis/dermatomyositis.'?,"No, the statement ""Coadministration of cyclosporin a with prednisolone in acute interstitial pneumonia complicating polymyositis/dermatomyositis"" does not provide any direct or indirect support for the claim ""Ibuprofen causes Toothache."" The two statements discuss unrelated medical issues (acute interstitial pneumonia complicating polymyositis/dermatomyositis vs toothache) and medications (cyclosporin a and prednisolone vs ibuprofen). + + Additionally, these statements come from different sources without any overlap in context or evidence that would allow for drawing connections between them. The first statement is focused on coadministration of cyclosporin a and prednisolone for treating acute interstitial pneumonia in polymyositis/dermatomyositis patients, while the second statement makes an unfounded claim about ibuprofen causing toothache without providing any supporting evidence or rationale. + + To establish a connection between these statements, one would need additional information linking ibuprofen use to toothache within the same context as the first statement. Since no" +12079834,Ibuprofen causes adult acute respiratory distress syndrome,127,"Efficacy of immunoglobulin plus prednisolone for prevention of coronary artery abnormalities in severe Kawasaki disease (RAISE study): a randomised, open-label, blinded-endpoints trial.",False,"Is the triple 'Ibuprofen causes adult acute respiratory distress syndrome' supported by the sentence: 'Efficacy of immunoglobulin plus prednisolone for prevention of coronary artery abnormalities in severe Kawasaki disease (RAISE study): a randomised, open-label, blinded-endpoints trial.'?","No, the statement does not provide any indirect support for the claim that ""Ibuprofen causes adult acute respiratory distress syndrome."" The RAISE study is focused on the efficacy of immunoglobulin plus prednisolone for prevention of coronary artery abnormalities in severe Kawasaki disease. It does not mention ibuprofen or acute respiratory distress syndrome at all. Therefore, it does not provide any basis for making such a connection or inferring causality between ibuprofen use and adult acute respiratory distress syndrome." +11157616,Ibuprofen causes Pain,128,"Response of vincristine, melphalan, cyclophosphamide and prednisolone in refractory multiple myeloma.",False,"Is the triple 'Ibuprofen causes Pain' supported by the sentence: 'Response of vincristine, melphalan, cyclophosphamide and prednisolone in refractory multiple myeloma.'?","No, the statement ""Response of vincristine, melphalan, cyclophosphamide and prednisolone in refractory multiple myeloma"" does not provide indirect support for the claim ""Ibuprofen causes Pain"". The statement discusses the effects of certain chemotherapeutic agents on refractory multiple myeloma, which is an unrelated topic to ibuprofen and its potential pain-causing effects." +10429873,Ibuprofen causes Hemorrhage,129,Pyruvate kinase M2 and prednisolone resistance in acute lymphoblastic leukemia.,False,Is the triple 'Ibuprofen causes Hemorrhage' supported by the sentence: 'Pyruvate kinase M2 and prednisolone resistance in acute lymphoblastic leukemia.'?,"No, the statement ""Pyruvate kinase M2 and prednisolone resistance in acute lymphoblastic leukemia"" does not provide indirect support for the claim ""Ibuprofen causes Hemorrhage."" The two statements discuss different concepts: pyruvate kinase M2 (PKM2) activation and prednisolone resistance in acute lymphoblastic leukemia (ALL) versus ibuprofen usage and hemorrhage risk. There is no connection between them that would allow for indirect support from one statement to the other. + + To further elaborate on why there is no connection between these two statements: + + - Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) commonly used for pain relief and reducing inflammation. Hemorrhage (or bleeding) is one potential side effect associated with long-term use or high doses due to its effect on platelet function and blood vessel dilation. + + - The second statement refers to pyruvate kinase M2 (PKM2) activation and prednisolone resistance in acute lymph" +9800201,Ibuprofen causes arthritic joint disease,130,"Stimulation with prednisolone and TNFalpha reduced GDF-5 expression in OA and RA fibroblasts, whereas MTX and IL-1beta revealed minor or no relevant change.",False,"Is the triple 'Ibuprofen causes arthritic joint disease' supported by the sentence: 'Stimulation with prednisolone and TNFalpha reduced GDF-5 expression in OA and RA fibroblasts, whereas MTX and IL-1beta revealed minor or no relevant change.'?","No, the statement does not provide any indirect support for the phrase ""Ibuprofen causes arthritic joint disease."" The statement discusses the effects of prednisolone, TNFalpha, MTX (methotrexate), and IL-1beta on GDF-5 (growth differentiation factor 5) expression in osteoarthritis (OA) and rheumatoid arthritis (RA) fibroblasts. Ibuprofen is not mentioned in the statement; therefore, it does not contribute any information that could be used to infer a relationship between ibuprofen and arthritic joint disease. + + To provide indirect support for the initial phrase, one would need information connecting ibuprofen usage with an increased risk or development of arthritic joint disease. As a computational biologist, it is important to base conclusions on relevant evidence presented in order to maintain accuracy in interpreting scientific literature." +8163776,Ibuprofen causes injury,131,"A combination of rituximab plus chemotherapy, rituximab+cyclophosphamide+doxorubicin+vincristine+prednisolone (R-CHOP), has the highest efficacy ever described with any chemotherapy in DLBCL and FL.",False,"Is the triple 'Ibuprofen causes injury' supported by the sentence: 'A combination of rituximab plus chemotherapy, rituximab+cyclophosphamide+doxorubicin+vincristine+prednisolone (R-CHOP), has the highest efficacy ever described with any chemotherapy in DLBCL and FL.'?","No, the statement does not provide indirect support for the phrase ""Ibuprofen causes injury."" The statement discusses the efficacy of a specific chemotherapy regimen (R-CHOP) in treating certain types of lymphoma (diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma (FL)). Ibuprofen is an over-the-counter nonsteroidal anti-inflammatory drug (NSAID) used for pain relief, fever reduction, and inflammation. The two statements discuss unrelated topics; therefore, there is no connection between them that would lend support to the claim about ibuprofen causing injury." +26701175,Ibuprofen affects rheumatoid arthritis,132,"A combination of rituximab plus chemotherapy, rituximab+cyclophosphamide+doxorubicin+vincristine+prednisolone (R-CHOP), has the highest efficacy ever described with any chemotherapy in DLBCL and FL.",False,"Is the triple 'Ibuprofen affects rheumatoid arthritis' supported by the sentence: 'A combination of rituximab plus chemotherapy, rituximab+cyclophosphamide+doxorubicin+vincristine+prednisolone (R-CHOP), has the highest efficacy ever described with any chemotherapy in DLBCL and FL.'?","No, the statement does not provide indirect support for the claim that ibuprofen affects rheumatoid arthritis. The statement discusses the efficacy of R-CHOP (a specific chemotherapy regimen) in treating diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma (FL). Ibuprofen is an analgesic and anti-inflammatory drug used primarily for pain relief, fever reduction, and inflammation. While both statements pertain to medical treatments, they discuss different conditions and therapeutic approaches without any overlap or connection between them that would allow for indirect support." +24384432,Ibuprofen affects migraine disorder,133,Weekly docetaxel and prednisolone versus prednisolone alone in androgen-independent prostate cancer: a randomized phase II study.,False,Is the triple 'Ibuprofen affects migraine disorder' supported by the sentence: 'Weekly docetaxel and prednisolone versus prednisolone alone in androgen-independent prostate cancer: a randomized phase II study.'?,"No, the statement does not provide indirect support for the phrase ""Ibuprofen affects migraine disorder."" The study mentioned is investigating the effects of docetaxel and prednisolone on androgen-independent prostate cancer, as indicated by its title: ""Weekly docetaxel and prednisolone versus prednisolone alone in androgen-independent prostate cancer: a randomized phase II study."" Ibuprofen is neither mentioned nor tested in this study; thus, there is no connection between the study results and ibuprofen's effects on migraines. + + + To further clarify, let us explore how indirect support could be established in other scenarios: + + + - If there were shared mechanisms between prostate cancer treatment and migraine prevention (e.g., anti-inflammatory effects), then studies showing benefits for prostate cancer could indirectly imply potential benefits for migraine treatment if ibuprofen were involved in those shared mechanisms. + + + - If ibuprofen were mentioned in another study investigating its effects on migraines, that would provide indirect support for ""Ibuprofen affects migraine disorder" +23500890,Ibuprofen affects adult acute respiratory distress syndrome,134,Prednisolone and azathioprine in membranous nephropathy: a 10-year follow-up study.,False,Is the triple 'Ibuprofen affects adult acute respiratory distress syndrome' supported by the sentence: 'Prednisolone and azathioprine in membranous nephropathy: a 10-year follow-up study.'?,"No, the statement ""Prednisolone and azathioprine in membranous nephropathy: a 10-year follow-up study"" does not provide any direct or indirect support for the claim that ""Ibuprofen affects adult acute respiratory distress syndrome."" The study in question focuses on prednisolone and azathioprine as treatments for membranous nephropathy over a 10-year period. Ibuprofen is not mentioned at all in the study, making it irrelevant in supporting or refuting the claim about ibuprofen's effects on adult acute respiratory distress syndrome." +21214366,Ibuprofen affects bronchopulmonary dysplasia,135,"Taken together, the present study points to a strong inhibitory effect of liposomal PLP on tumor angiogenesis by reduction of the intratumoral production of the majority of pro-angiogenic factors studied and direct inhibition of endothelial cell proliferation, which is the result of high prolonged levels of prednisolone in the tumor by liposomal delivery.",False,"Is the triple 'Ibuprofen affects bronchopulmonary dysplasia' supported by the sentence: 'Taken together, the present study points to a strong inhibitory effect of liposomal PLP on tumor angiogenesis by reduction of the intratumoral production of the majority of pro-angiogenic factors studied and direct inhibition of endothelial cell proliferation, which is the result of high prolonged levels of prednisolone in the tumor by liposomal delivery.'?","No, the statement does not provide indirect support for the phrase ""Ibuprofen affects bronchopulmonary dysplasia."" The statement discusses the inhibitory effect of liposomal PLP on tumor angiogenesis through reducing pro-angiogenic factors and inhibiting endothelial cell proliferation due to high prolonged levels of prednisolone in the tumor by liposomal delivery. This information is related to tumor angiogenesis and drug delivery mechanisms rather than ibuprofen and bronchopulmonary dysplasia." +20886939,Ibuprofen affects Cognitive impairment,136,Prednisolone versus dexamethasone in croup: a randomised equivalence trial.,False,Is the triple 'Ibuprofen affects Cognitive impairment' supported by the sentence: 'Prednisolone versus dexamethasone in croup: a randomised equivalence trial.'?,"No, the statement ""Prednisolone versus dexamethasone in croup: a randomised equivalence trial"" does not provide any direct or indirect support for the claim that ""Ibuprofen affects Cognitive impairment."" This study investigates the effects of prednisolone versus dexamethasone on croup in children; it does not involve ibuprofen nor cognitive impairment in any way that would allow for an inference regarding ibuprofen's impact on cognitive impairment." +18977843,Ibuprofen affects Headache,137,Use of ACTH and prednisolone in infantile spasms: experience from a developing country.,False,Is the triple 'Ibuprofen affects Headache' supported by the sentence: 'Use of ACTH and prednisolone in infantile spasms: experience from a developing country.'?,"No, the statement ""Use of ACTH and prednisolone in infantile spasms: experience from a developing country"" does not provide any direct or indirect support for the phrase ""Ibuprofen affects Headache."" The study primarily focuses on the use of ACTH (Adrenocorticotropic hormone) and prednisolone in treating infantile spasms in a developing country setting. Ibuprofen is not mentioned in the study, nor is there any discussion about headaches or related topics. Therefore, it is not appropriate to draw any conclusions about ibuprofen's effect on headaches based on this study." +15746938,Ibuprofen affects injury,138,Bone mineral density in relation to efficacy and side effects of budesonide and prednisolone in Crohn's disease.,False,Is the triple 'Ibuprofen affects injury' supported by the sentence: 'Bone mineral density in relation to efficacy and side effects of budesonide and prednisolone in Crohn's disease.'?,"No, the phrase ""Ibuprofen affects injury"" does not receive indirect support from the statement: ""Bone mineral density in relation to efficacy and side effects of budesonide and prednisolone in Crohn's disease."" + + The statement provided discusses bone mineral density in relation to two specific pharmaceutical drugs (budesonide and prednisolone) used in treating Crohn's disease, which is an inflammatory bowel disease. Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) commonly used for pain relief, including injuries. + + Although both ibuprofen and budesonide/prednisolone have anti-inflammatory effects, they function differently and target various biological pathways. The statement does not provide any information about ibuprofen or its effects on injuries. Therefore, it does not offer indirect support for the claim that ""Ibuprofen affects injury."" + + However, it is worth mentioning that there is an established body of evidence indicating that NSAIDs like ibuprofen can negatively affect bone health by decreasing bone formation and increasing bone" +13826486,Ibuprofen affects osteoarthritis,139,OBJECTIVE: To examine the safety and efficacy of methotrexate (MTX) plus low-dose prednisolone for induction of remission in non life- or organ-threatening courses and for remission maintenance in Churg-Strauss syndrome (CSS).,False,Is the triple 'Ibuprofen affects osteoarthritis' supported by the sentence: 'OBJECTIVE: To examine the safety and efficacy of methotrexate (MTX) plus low-dose prednisolone for induction of remission in non life- or organ-threatening courses and for remission maintenance in Churg-Strauss syndrome (CSS).'?,"No, the statement does not provide any direct or indirect support for the phrase ""Ibuprofen affects osteoarthritis."" The objective in the statement is focused on examining the safety and efficacy of methotrexate (MTX) plus low-dose prednisolone for induction of remission in non life- or organ-threatening courses and for remission maintenance in Churg-Strauss syndrome (CSS). Ibuprofen is not mentioned in the statement at all, let alone its potential effects on osteoarthritis." +13584223,Ibuprofen affects Cognitive impairment,140,OBJECTIVE: To determine whether addition of low dose prednisolone to multidrug treatment can prevent reaction and nerve function impairment in leprosy.,False,Is the triple 'Ibuprofen affects Cognitive impairment' supported by the sentence: 'OBJECTIVE: To determine whether addition of low dose prednisolone to multidrug treatment can prevent reaction and nerve function impairment in leprosy.'?,"No, the statement does not provide any direct or indirect support for the claim that ""Ibuprofen affects Cognitive impairment"". The objective in the statement is focused on determining whether adding low-dose prednisolone (a steroid medication) to multidrug treatment can prevent reaction and nerve function impairment in leprosy patients. There is no mention of ibuprofen, cognitive impairment, or any related concepts in this statement." +12659717,Ibuprofen affects Fever,141,A double-blind randomized controlled trial of infliximab associated with prednisolone in acute alcoholic hepatitis.,False,Is the triple 'Ibuprofen affects Fever' supported by the sentence: 'A double-blind randomized controlled trial of infliximab associated with prednisolone in acute alcoholic hepatitis.'?,"No, the statement ""A double-blind randomized controlled trial of infliximab associated with prednisolone in acute alcoholic hepatitis"" does not provide direct or indirect support for the claim that ""Ibuprofen affects Fever."" + + This study investigates the effects of infliximab combined with prednisolone on acute alcoholic hepatitis. The medications involved in this trial have no direct relationship to ibuprofen, which is an over-the-counter nonsteroidal anti-inflammatory drug (NSAID) commonly used for pain relief, fever reduction, and inflammation. + + While ibuprofen is known for its ability to reduce fever by inhibiting prostaglandin synthesis in the hypothalamus, the evidence presented in this statement does not contribute any new information that would support or refute that understanding. + + In conclusion, it is essential to remain cautious when drawing connections between unrelated studies or statements since doing so may lead to incorrect conclusions and misunderstandings in interpreting evidence-based knowledge." +11207850,Ibuprofen affects peptic ulcer disease,142,EULAR randomised controlled trial of pulse cyclophosphamide and methylprednisolone versus continuous cyclophosphamide and prednisolone followed by azathioprine and prednisolone in lupus nephritis.,False,Is the triple 'Ibuprofen affects peptic ulcer disease' supported by the sentence: 'EULAR randomised controlled trial of pulse cyclophosphamide and methylprednisolone versus continuous cyclophosphamide and prednisolone followed by azathioprine and prednisolone in lupus nephritis.'?,"No, the statement does not provide any direct or indirect support for the claim that ""Ibuprofen affects peptic ulcer disease."" The EULAR randomized controlled trial mentioned in the statement is focused on comparing different treatment regimens for lupus nephritis. Ibuprofen is not mentioned in the statement at all, let alone in relation to peptic ulcer disease. Therefore, it is not possible to draw any conclusions about ibuprofen's effects on peptic ulcer disease based on this statement alone." +11159990,Ibuprofen affects Hemorrhage,143,OBJECTIVE: To investigate the safety and efficacy of leflunomide plus low-dose prednisolone for the maintenance of remission in Wegener's granulomatosis (WG).,False,Is the triple 'Ibuprofen affects Hemorrhage' supported by the sentence: 'OBJECTIVE: To investigate the safety and efficacy of leflunomide plus low-dose prednisolone for the maintenance of remission in Wegener's granulomatosis (WG).'?,"No, the statement does not provide any direct or indirect support for the phrase ""Ibuprofen affects Hemorrhage."" The objective in question is about investigating the safety and efficacy of leflunomide plus low-dose prednisolone for maintaining remission in Wegener's granulomatosis (WG). Ibuprofen is not mentioned in this statement, nor is there any implied connection between ibuprofen use and hemorrhage incidence in patients suffering from WG or other related conditions. It is essential to base conclusions on specific evidence related to the subject matter under consideration." +10170540,Ibuprofen affects patent ductus arteriosus,144,"Treatment with combined therapy of adriamycin, vincristine and prednisolone produced a remission in the leukaemia with complete resolution of the breast mass.",False,"Is the triple 'Ibuprofen affects patent ductus arteriosus' supported by the sentence: 'Treatment with combined therapy of adriamycin, vincristine and prednisolone produced a remission in the leukaemia with complete resolution of the breast mass.'?","No, the statement does not provide any direct or indirect support for the phrase ""Ibuprofen affects patent ductus arteriosus"". The statement discusses the effects of a combined therapy (adriamycin, vincristine, and prednisolone) on leukaemia and breast mass resolution, which is unrelated to ibuprofen and its potential impact on patent ductus arteriosus (PDA), a congenital heart defect in newborns. Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) commonly used for pain relief and reducing inflammation, while adriamycin, vincristine, and prednisolone are chemotherapy drugs used in cancer treatment. Therefore, these two scenarios involve different medical contexts and therapeutic agents, making it impossible to draw any connection between them." +10026104,Ibuprofen affects Myalgia,145,RESULTS: The average initial dose of prednisolone in polymyalgia rheumatica was 35 mg; 51 of 62 patients were given a starting dose exceeding 15 mg.,False,Is the triple 'Ibuprofen affects Myalgia' supported by the sentence: 'RESULTS: The average initial dose of prednisolone in polymyalgia rheumatica was 35 mg; 51 of 62 patients were given a starting dose exceeding 15 mg.'?,"No, the statement does not provide indirect support for the phrase ""Ibuprofen affects Myalgia."" The statement discusses the initial dose of prednisolone given to patients with polymyalgia rheumatica but does not mention ibuprofen or myalgia at all. Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) used for pain relief, while myalgia refers to muscle pain or tenderness; they have no direct connection to prednisolone or polymyalgia rheumatica in this context." +9889792,Ibuprofen affects Hemorrhage,146,[Trans-utero-tubal administration of prednisolone in sterility caused by obstruction of the tubes].,False,Is the triple 'Ibuprofen affects Hemorrhage' supported by the sentence: '[Trans-utero-tubal administration of prednisolone in sterility caused by obstruction of the tubes].'?,"No, the statement does not provide any direct or indirect support for the phrase ""Ibuprofen affects Hemorrhage."" The statement discusses the administration of prednisolone in sterility caused by obstruction of the tubes, which is unrelated to ibuprofen and hemorrhage. Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) commonly used for pain relief, whereas prednisolone is a corticosteroid medication used for suppressing the immune system and reducing inflammation in various conditions. Hemorrhage refers to excessive bleeding, which is not mentioned in the provided statement." +8819538,Ibuprofen affects osteoarthritis,147,[On experiences with a combination preparation from prednisolone and an antihistaminic in dermatology especially in endogenous eczema].,False,Is the triple 'Ibuprofen affects osteoarthritis' supported by the sentence: '[On experiences with a combination preparation from prednisolone and an antihistaminic in dermatology especially in endogenous eczema].'?,"No, the statement does not provide any direct or indirect support for the claim that ""Ibuprofen affects osteoarthritis."" The statement discusses the use of prednisolone and an antihistaminic in dermatology, specifically for endogenous eczema. It does not mention ibuprofen or osteoarthritis at all. Therefore, it does not contribute any relevant information to evaluate the claim about ibuprofen's effect on osteoarthritis." +8421263,Ibuprofen affects Fever,148,[USE OF PREDNISOLONE IN SOME GRAVE FORMS OF PATHOLOGY OF THE PREMATURE INFANT].,False,Is the triple 'Ibuprofen affects Fever' supported by the sentence: '[USE OF PREDNISOLONE IN SOME GRAVE FORMS OF PATHOLOGY OF THE PREMATURE INFANT].'?,"No, the statement does not provide any direct or indirect support for the claim that ibuprofen affects fever in individuals. The statement discusses the use of prednisolone in some grave forms of pathology in premature infants, while the claim is about ibuprofen affecting fever in general populations. The two statements refer to different medications and contexts; therefore, there is no connection between them that would support the claim about ibuprofen affecting fever." +27630106,Ibuprofen disrupts Acute Pain,149,[EFFECT OF PREDNISOLONE ON THE CARDIAC ACTIVITY IN LIVER AND KIDNEY DISEASES AND IN RHEUMATISM].,False,Is the triple 'Ibuprofen disrupts Acute Pain' supported by the sentence: '[EFFECT OF PREDNISOLONE ON THE CARDIAC ACTIVITY IN LIVER AND KIDNEY DISEASES AND IN RHEUMATISM].'?,"No, the statement does not provide any direct or indirect support for the phrase ""Ibuprofen disrupts Acute Pain"". The statement discusses the effects of Prednisolone on cardiac activity in liver and kidney diseases as well as rheumatism. It does not mention Ibuprofen or acute pain at all. Therefore, it does not contribute to our understanding or validation of that specific claim." +23399675,Ibuprofen disrupts Myalgia,150,"In this limited pilot study, we compared the effect on clinical outcome of treating Pseudomonas keratitis in guinea pigs with prednisolone (a corticosteroid), flurbiprofen (a cyclo-oxygenase inhibitor), nordihydroguaiaretic acid (a lipoxygenase inhibitor), and a leukotriene antagonist, SKF104353 [R-(R*, S*)]-beta-[(2-carboxyethyl) thio-alpha-hydroxy-2-(8-phenyloctyl) benzenepropanoic acid, zinc salt].",False,"Is the triple 'Ibuprofen disrupts Myalgia' supported by the sentence: 'In this limited pilot study, we compared the effect on clinical outcome of treating Pseudomonas keratitis in guinea pigs with prednisolone (a corticosteroid), flurbiprofen (a cyclo-oxygenase inhibitor), nordihydroguaiaretic acid (a lipoxygenase inhibitor), and a leukotriene antagonist, SKF104353 [R-(R*, S*)]-beta-[(2-carboxyethyl) thio-alpha-hydroxy-2-(8-phenyloctyl) benzenepropanoic acid, zinc salt].'?","No, the statement does not provide indirect support for the phrase ""Ibuprofen disrupts Myalgia."" The study referenced in the statement investigates different treatments for Pseudomonas keratitis in guinea pigs, including prednisolone, flurbiprofen, nordihydroguaiaretic acid, and SKF104353. Ibuprofen is not mentioned in the study, so there is no connection between its effects on myalgia and the results presented in this study. Myalgia is muscle pain or discomfort, while Pseudomonas keratitis is an eye infection; these conditions have different underlying causes and would require different treatments." +18599970,Ibuprofen disrupts arthritic joint disease,151,URINARY EXCRETION OF PREDNISOLONE AFTER INTRARECTAL THERAPY IN ULCERATIVE COLITIS.,False,Is the triple 'Ibuprofen disrupts arthritic joint disease' supported by the sentence: 'URINARY EXCRETION OF PREDNISOLONE AFTER INTRARECTAL THERAPY IN ULCERATIVE COLITIS.'?,"No, the statement ""URINARY EXCRETION OF PREDNISOLONE AFTER INTRARECTAL THERAPY IN ULCERATIVE COLITIS"" does not provide indirect support for the phrase ""Ibuprofen disrupts arthritic joint disease."" The statement pertains specifically to prednisolone excretion in patients with ulcerative colitis who have undergone intrarectal therapy, which is unrelated to ibuprofen's potential effects on arthritic joint disease." +15072611,Ibuprofen disrupts Fever,152,"Male rats treated with either budesonide, prednisolone, or triamcinolone acetonide in drinking water for up to 104 weeks developed slightly increased incidences of basophilic foci, and significantly increased incidences of combined hepatocellular adenomas/carcinomas as compared to controls.",False,"Is the triple 'Ibuprofen disrupts Fever' supported by the sentence: 'Male rats treated with either budesonide, prednisolone, or triamcinolone acetonide in drinking water for up to 104 weeks developed slightly increased incidences of basophilic foci, and significantly increased incidences of combined hepatocellular adenomas/carcinomas as compared to controls.'?","No, the statement does not provide indirect support for the phrase ""Ibuprofen disrupts Fever"". The statement discusses the effects of three different corticosteroids (budesonide, prednisolone, and triamcinolone acetonide) on rats over an extended period (up to 104 weeks), focusing on hepatic lesions (basophilic foci and hepatocellular adenomas/carcinomas). Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) used primarily for its analgesic, antipyretic, and anti-inflammatory properties; it does not belong to the class of corticosteroids mentioned in the given statement. + + The provided statement does not contain any information about Ibuprofen, fever disruption, or even any other physiological effects that could be interpreted as indirectly related to Ibuprofen disrupting fever. Therefore, it does not offer any support for that particular claim. + + However, it is important to note that while Ibuprofen is not directly related to corticosteroids" +14486259,Ibuprofen disrupts Pain,153,[On the use of prednisolone in hemolytic anemia of the newborn caused by fetomaternal Rh-factor incompatibility].,False,Is the triple 'Ibuprofen disrupts Pain' supported by the sentence: '[On the use of prednisolone in hemolytic anemia of the newborn caused by fetomaternal Rh-factor incompatibility].'?,"No, the statement does not provide any direct or indirect support for the phrase ""Ibuprofen disrupts Pain"". The statement discusses the use of prednisolone in hemolytic anemia of the newborn caused by fetomaternal Rh-factor incompatibility, which is unrelated to ibuprofen's effect on pain. Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) used for its analgesic (pain-relieving) properties among other things, while prednisolone is a corticosteroid used primarily for its anti-inflammatory effects in various clinical scenarios." +8331095,Ibuprofen disrupts Alzheimer disease,154,Long-term use of prednisone and prednisolone in juvenile rheumatoid arthritis; a report of fifteen cases.,False,Is the triple 'Ibuprofen disrupts Alzheimer disease' supported by the sentence: 'Long-term use of prednisone and prednisolone in juvenile rheumatoid arthritis; a report of fifteen cases.'?,"No, the statement ""Long-term use of prednisone and prednisolone in juvenile rheumatoid arthritis; a report of fifteen cases"" does not provide indirect support for the phrase ""Ibuprofen disrupts Alzheimer disease."" + + + The reason is that prednisone and prednisolone are corticosteroids, while ibuprofen is a non-steroidal anti-inflammatory drug (NSAID). They have different mechanisms of action and therapeutic effects. The study mentioned focuses on the long-term use of corticosteroids in juvenile rheumatoid arthritis, which does not provide any relevant information about ibuprofen or its potential effects on Alzheimer disease. + + + Furthermore, even if the statement were about an NSAID, it would still not provide indirect support for the claim about Alzheimer disease. This is because Alzheimer disease is a complex neurodegenerative disorder, and while some studies suggest that NSAIDs may have potential benefits in reducing amyloid-beta levels (a hallmark of Alzheimer disease), other studies" +25657729,Ibuprofen prevents hypertensive disorder,155,[Effect of prednisolone and human albumin on protein excretion in nephrotic syndrome].,False,Is the triple 'Ibuprofen prevents hypertensive disorder' supported by the sentence: '[Effect of prednisolone and human albumin on protein excretion in nephrotic syndrome].'?,"No, the statement does not provide any direct or indirect support for the phrase ""Ibuprofen prevents hypertensive disorder."" The title refers to a study examining the effect of prednisolone and human albumin on protein excretion in nephrotic syndrome. Ibuprofen is neither mentioned nor alluded to in this statement; therefore, it does not offer any evidence regarding ibuprofen's potential impact on hypertensive disorders." +22159382,Ibuprofen prevents Hemorrhage,156,[Therapeutic results of metacortandralone or prednisolone in allergy].,False,Is the triple 'Ibuprofen prevents Hemorrhage' supported by the sentence: '[Therapeutic results of metacortandralone or prednisolone in allergy].'?,"No, the statement ""Ibuprofen prevents Hemorrhage"" does not receive indirect support from the statement ""[Therapeutic results of metacortandralone or prednisolone in allergy]."" + + + + Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) commonly used for pain relief, fever reduction, and inflammation. It does not have any direct effects on preventing hemorrhage (bleeding). On the other hand, metacortandralone and prednisolone are corticosteroids used primarily for their anti-inflammatory and immunosuppressive effects in treating allergies and other conditions involving an overactive immune response. + + + + The statement about therapeutic results from metacortandralone or prednisolone in allergy does not provide any information that would suggest an association or effect on ibuprofen or its potential ability to prevent hemorrhage. The two drugs belong to different classes with distinct mechanisms of action; therefore, any conclusions drawn about ibuprofen based on information about corticosteroids would be unwarr" +22123299,Ibuprofen prevents Fever,157,Primary resistance to vincristine (Vcr) and prednisolone in untreated AML was observed as well as 'acquired' resistance to several other antileukemic drugs.,False,Is the triple 'Ibuprofen prevents Fever' supported by the sentence: 'Primary resistance to vincristine (Vcr) and prednisolone in untreated AML was observed as well as 'acquired' resistance to several other antileukemic drugs.'?,"No, the statement does not provide any direct or indirect support for the phrase ""Ibuprofen prevents fever."" The statement discusses resistance to certain drugs (vincristine and prednisolone) in acute myeloid leukemia (AML), which is unrelated to ibuprofen's effect on fever. Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) used for its analgesic (pain-relieving), antipyretic (fever-reducing), and anti-inflammatory properties. The statement discussing drug resistance in AML does not provide any relevant context or evidence that would support the claim that ibuprofen prevents fever." +21354514,Ibuprofen prevents pancreatitis,158,"REPORT of the Committee on New Drugs of the Research Council of the American Academy of Allergy, 1955-56; studies on prednisone and prednisolone in ragweed pollinosis.",False,"Is the triple 'Ibuprofen prevents pancreatitis' supported by the sentence: 'REPORT of the Committee on New Drugs of the Research Council of the American Academy of Allergy, 1955-56; studies on prednisone and prednisolone in ragweed pollinosis.'?","No, the statement ""Ibuprofen prevents pancreatitis"" does not receive indirect support from the provided report on studies about prednisone and prednisolone in ragweed pollinosis from 1955-56. The subjects in these studies were patients suffering from allergies, not pancreatitis; hence, it does not provide any relevant information regarding ibuprofen's effect on pancreatitis prevention. + + To further elaborate, indirect support for a claim may be established when similar studies or evidence share commonalities that suggest similar outcomes or mechanisms; however, in this case, there is no overlap in terms of drug compounds, medical conditions, or study objectives between the original statement and the provided report. Therefore, it is not appropriate to infer any support for the claim based on the given report." +20691057,Ibuprofen prevents altitude sickness,159,Effects of prednisone and prednisolone in ocular inflammation.,False,Is the triple 'Ibuprofen prevents altitude sickness' supported by the sentence: 'Effects of prednisone and prednisolone in ocular inflammation.'?,"No, the statement ""Effects of prednisone and prednisolone in ocular inflammation"" does not provide indirect support for the claim that ""Ibuprofen prevents altitude sickness."" + + Prednisone and prednisolone are corticosteroids used for their anti-inflammatory effects in treating various conditions such as ocular inflammation. Ibuprofen, on the other hand, is a non-steroidal anti-inflammatory drug (NSAID) commonly used for pain relief, fever reduction, and inflammation. + + Although both prednisone/prednisolone and ibuprofen have anti-inflammatory properties, they have different mechanisms of action and are used for different therapeutic purposes. Additionally, altitude sickness is not an inflammatory condition but rather is caused by insufficient acclimatization to high altitudes due to lower oxygen levels. + + The lack of connection between ocular inflammation (treated by prednisone/prednisolone) and altitude sickness (purportedly prevented by ibuprofen) indicates that there is no indirect support for" +19399624,Ibuprofen prevents osteoarthritis,160,"Prednisolone scored better than prednisone in the categories of texture, taste, and aftertaste (p < 0.05); there was no statistical difference in smell.",False,"Is the triple 'Ibuprofen prevents osteoarthritis' supported by the sentence: 'Prednisolone scored better than prednisone in the categories of texture, taste, and aftertaste (p < 0.05); there was no statistical difference in smell.'?","No, the statement does not provide any indirect support for the claim that ""Ibuprofen prevents osteoarthritis"". The provided information compares prednisolone and prednisone in terms of texture, taste, and aftertaste, where prednisolone scored better than prednisone (p < 0.05), but there was no statistical difference in smell between them. Ibuprofen is an NSAID (non-steroidal anti-inflammatory drug) used for pain relief and reducing inflammation, whereas prednisolone and prednisone belong to a class of steroid medications used for their anti-inflammatory effects as well as for suppressing immune response. + + The two statements discuss different drugs that have different mechanisms of action; therefore, there is no connection between them that would allow for indirect support for the claim about ibuprofen preventing osteoarthritis." +17687542,Ibuprofen prevents canker sore,161,Plasma prednisolone levels after administration of prednisolone-21-phosphate as a retention enema in colitis.,False,Is the triple 'Ibuprofen prevents canker sore' supported by the sentence: 'Plasma prednisolone levels after administration of prednisolone-21-phosphate as a retention enema in colitis.'?,"No, there is no direct or indirect support for the claim that ibuprofen prevents canker sores from the provided statement about plasma prednisolone levels after administration of prednisolone-21-phosphate as a retention enema in colitis. The two statements discuss different medications (ibuprofen vs prednisolone-21-phosphate) and different medical conditions (canker sores vs colitis). Therefore, no meaningful connection can be drawn between them based on the information provided." +15961024,Ibuprofen prevents Dysmenorrhea,162,Mizoribine as an effective combined maintenance therapy with prednisolone in child-onset systemic lupus erythematosus.,False,Is the triple 'Ibuprofen prevents Dysmenorrhea' supported by the sentence: 'Mizoribine as an effective combined maintenance therapy with prednisolone in child-onset systemic lupus erythematosus.'?,"No, the statement does not provide any direct or indirect support for the claim that ibuprofen prevents dysmenorrhea. The two statements discuss different medical conditions and treatments: one is about ibuprofen as it relates to dysmenorrhea (menstrual cramps), while the other is about mizoribine and prednisolone as they relate to child-onset systemic lupus erythematosus (SLE), an autoimmune disease. + + While ibuprofen is also an anti-inflammatory drug like mizoribine, it is used for pain relief in various conditions such as dysmenorrhea, headaches, arthritis, and minor injuries. The statement about mizoribine in SLE therapy does not mention ibuprofen, nor does it provide any information about ibuprofen's potential effects on dysmenorrhea. + + In conclusion, without additional evidence connecting ibuprofen and dysmenorrhea prevention within the context of the provided statement, there is no basis for inferring support for that claim from it." +13710734,Ibuprofen prevents Chronic pain,163,Controlled prospective trial of prednisolone and cytotoxics in progressive IgA nephropathy.,False,Is the triple 'Ibuprofen prevents Chronic pain' supported by the sentence: 'Controlled prospective trial of prednisolone and cytotoxics in progressive IgA nephropathy.'?,"No, the statement ""Controlled prospective trial of prednisolone and cytotoxics in progressive IgA nephropathy"" does not provide any direct or indirect support for the claim ""Ibuprofen prevents Chronic pain."" The study mentioned investigates the effects of prednisolone and cytotoxics on IgA nephropathy, which is a kidney disease, but it does not involve Ibuprofen or chronic pain prevention in any way that would allow us to infer support for that particular claim." +10201705,Ibuprofen prevents Headache,164,"We propose that FE(NO) is associated with eosinophilic inflammation in children with difficult asthma, following prednisolone, and may help in identifying patients in whom persistent symptoms are associated with airway eosinophilia.",False,"Is the triple 'Ibuprofen prevents Headache' supported by the sentence: 'We propose that FE(NO) is associated with eosinophilic inflammation in children with difficult asthma, following prednisolone, and may help in identifying patients in whom persistent symptoms are associated with airway eosinophilia.'?","No, the statement does not provide indirect support for the phrase ""Ibuprofen prevents Headache."" The statement discusses the association between FE(NO) levels and eosinophilic inflammation in children with difficult asthma following prednisolone treatment. Ibuprofen is not mentioned in the statement, nor is there any connection made between ibuprofen use and headache prevention. To provide indirect support for such a claim, there would need to be some link between ibuprofen, headaches, asthma, eosinophilic inflammation, or prednisolone in the statement, but no such link exists here." +10026105,Ibuprofen prevents Myalgia,165,"Liposomal daunorubicin (DaunoXome) in combination with cyclophosphamide, vincristine and prednisolone (COP-X) as salvage therapy in poor-prognosis non-Hodgkins lymphoma.",False,"Is the triple 'Ibuprofen prevents Myalgia' supported by the sentence: 'Liposomal daunorubicin (DaunoXome) in combination with cyclophosphamide, vincristine and prednisolone (COP-X) as salvage therapy in poor-prognosis non-Hodgkins lymphoma.'?","No, the statement does not provide indirect support for the phrase ""Ibuprofen prevents Myalgia"". The two statements discuss different subjects: one is about liposomal daunorubicin (DaunoXome) in combination with cyclophosphamide, vincristine and prednisolone (COP-X) as salvage therapy in poor-prognosis non-Hodgkins lymphoma, while the other is about ibuprofen preventing myalgia (muscle pain). + + Myalgia is not mentioned in the statement about DaunoXome and COP-X therapy for non-Hodgkins lymphoma. Furthermore, ibuprofen is not mentioned in the statement either. Therefore, it is not possible to infer any relationship between ibuprofen preventing myalgia from that statement about non-Hodgkins lymphoma treatment. + + In order for one statement to indirectly support another statement, there needs to be some commonality in subject matter between them that allows for an inference or conclusion to be drawn from one statement that is applicable to the other statement. In this case, there is no such common" +9104502,Ibuprofen prevents injury,166,Prednisolone in Duchenne muscular dystrophy.,False,Is the triple 'Ibuprofen prevents injury' supported by the sentence: 'Prednisolone in Duchenne muscular dystrophy.'?,"No, the statement ""Prednisolone in Duchenne muscular dystrophy"" does not provide indirect support for the phrase ""Ibuprofen prevents injury."" The two statements discuss different drugs (Prednisolone and Ibuprofen) and their effects on different medical conditions (Duchenne muscular dystrophy and injury prevention). Therefore, it is not appropriate to draw inferences about Ibuprofen preventing injury based on the given statement about Prednisolone in Duchenne muscular dystrophy." +9022792,Ibuprofen prevents Pain,167,Intravenous prednisolone in chronic bronchial asthma.,False,Is the triple 'Ibuprofen prevents Pain' supported by the sentence: 'Intravenous prednisolone in chronic bronchial asthma.'?,"No, the statement ""Intravenous prednisolone in chronic bronchial asthma"" does not provide indirect support for the claim ""Ibuprofen prevents pain."" These two statements discuss different medical treatments (prednisolone for chronic bronchial asthma vs ibuprofen for pain) in different administration forms (intravenous vs oral). The connection between them is too tenuous to infer any supportive relationship regarding pain prevention by ibuprofen." +8584177,Ibuprofen prevents patent ductus arteriosus,168,Reversibility with prednisolone is rarely seen in COPD.,False,Is the triple 'Ibuprofen prevents patent ductus arteriosus' supported by the sentence: 'Reversibility with prednisolone is rarely seen in COPD.'?,"No, the statement ""Reversibility with prednisolone is rarely seen in COPD"" does not provide indirect support for the phrase ""Ibuprofen prevents patent ductus arteriosus"". These two statements discuss different subjects - one refers to Ibuprofen preventing patent ductus arteriosus in neonates while the other mentions prednisolone reversibility in Chronic Obstructive Pulmonary Disease (COPD). + + The only connection between them would be if they shared common underlying mechanisms or risk factors; however, no such link has been established in either statement provided. + + To further clarify: + + 1) Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) used for pain relief, fever reduction, and inflammation control. Its use in neonates can help prevent patent ductus arteriosus (PDA), which is an abnormal connection between two major blood vessels leading from the heart. + + 2) Prednisolone is a corticosteroid used for treating various conditions like allergies, skin disorders, and COPD. Reversibility in COPD refers" +7843138,Ibuprofen prevents Alzheimer disease,169,"In spite of the fact that prednisolone-based treatment of pemphigus patients has proved to be effective in controlling the disease, some undesirable effects associated with this form of treatment have prompted investigation into other therapeutic approaches.",False,"Is the triple 'Ibuprofen prevents Alzheimer disease' supported by the sentence: 'In spite of the fact that prednisolone-based treatment of pemphigus patients has proved to be effective in controlling the disease, some undesirable effects associated with this form of treatment have prompted investigation into other therapeutic approaches.'?","No, the statement does not provide indirect support for the claim that ibuprofen prevents Alzheimer's disease. The statement discusses the use of prednisolone in treating pemphigus patients and explores alternative therapeutic approaches due to undesirable effects. Ibuprofen is not mentioned in the statement, nor is there any connection made between nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen and Alzheimer's disease prevention. The statement primarily focuses on pemphigus treatment options and their side effects." +15342704,Ibuprofen exacerbates injury,170,One reason for the good clinical effects of prednisolone in RA could be a down-regulation of adhesion and phagocytosis receptors on monocytes.,False,Is the triple 'Ibuprofen exacerbates injury' supported by the sentence: 'One reason for the good clinical effects of prednisolone in RA could be a down-regulation of adhesion and phagocytosis receptors on monocytes.'?,"No, the statement does not provide indirect support for the phrase ""Ibuprofen exacerbates injury."" The statement discusses the clinical effects of prednisolone in rheumatoid arthritis (RA) and its potential impact on down-regulating adhesion and phagocytosis receptors on monocytes. Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) that works through different mechanisms than prednisolone, primarily by inhibiting cyclooxygenase enzymes leading to reduced prostaglandin synthesis. There is no mention in the statement about ibuprofen exacerbating injury or interacting negatively with RA treatment in any way." +20007370,Ibuprofen predisposes cerebral palsy,171,OBJECTIVE: To appraise the adjunctive role of prednisolone (PN) in pulmonary tuberculosis (PTB) with toxic reactions.,False,Is the triple 'Ibuprofen predisposes cerebral palsy' supported by the sentence: 'OBJECTIVE: To appraise the adjunctive role of prednisolone (PN) in pulmonary tuberculosis (PTB) with toxic reactions.'?,"No, the statement does not provide any indirect support for the phrase ""Ibuprofen predisposes cerebral palsy."" The objective in the statement is focused on appraising the adjunctive role of prednisolone in pulmonary tuberculosis, including its toxic reactions. Ibuprofen is not mentioned in the statement, nor is there any connection made between ibuprofen use and cerebral palsy. It is important to base conclusions on relevant evidence specific to the claim in question." +14332005,Ibuprofen predisposes bronchopulmonary dysplasia,172,"A significant reduction of survival was found with the presence of permanent visual loss vs absence (p = 0.04), in patients who required more than 10 mg/d of glucocorticoid (p < 0.001) at 6 months treatment and in patients treated with prednisone (vs prednisolone) (p < 0.01).",False,"Is the triple 'Ibuprofen predisposes bronchopulmonary dysplasia' supported by the sentence: 'A significant reduction of survival was found with the presence of permanent visual loss vs absence (p = 0.04), in patients who required more than 10 mg/d of glucocorticoid (p < 0.001) at 6 months treatment and in patients treated with prednisone (vs prednisolone) (p < 0.01).'?","No, the statement does not provide indirect support for the phrase ""Ibuprofen predisposes bronchopulmonary dysplasia."" The statement discusses factors associated with reduced survival in patients treated for retinopathy of prematurity (ROP), including glucocorticoid dosage, specific glucocorticoid types (prednisone vs prednisolone), and visual loss. Ibuprofen is not mentioned in the statement, nor is there any information linking it to bronchopulmonary dysplasia (BPD). + + + Bronchopulmonary dysplasia is primarily associated with prematurity, oxygen therapy, and mechanical ventilation, not specifically with ibuprofen usage. If there were an indirect link between ibuprofen usage and BPD, it would require additional evidence that ibuprofen increases the likelihood or severity of factors associated with BPD (e.g., lung injury). + + + In summary, without explicit mention or evidence linking ibuprofen usage to bronchopulmonary dysplasia in the provided statement, it does not offer indirect support for that claim." +14294004,Ibuprofen predisposes Alzheimer disease,173,"Fourteen patients developed hyperglycemia during induction therapy of acute lymphoblastic leukemia with L-asparaginase, prednisolone, vincristine and daunorubicin.",False,"Is the triple 'Ibuprofen predisposes Alzheimer disease' supported by the sentence: 'Fourteen patients developed hyperglycemia during induction therapy of acute lymphoblastic leukemia with L-asparaginase, prednisolone, vincristine and daunorubicin.'?","No, the statement does not provide any indirect support for the claim that ibuprofen predisposes Alzheimer disease. The statement discusses patients who developed hyperglycemia during induction therapy for acute lymphoblastic leukemia using specific drugs, while the claim associates ibuprofen use with Alzheimer disease risk. The two statements discuss different medical conditions and drugs, thus they do not support each other." +14085648,Ibuprofen predisposes injury,174,A 66-year-old man was treated for IgD (lambda) multiple myeloma with 2mg/day melphalan and 20mg/day prednisolone.,False,Is the triple 'Ibuprofen predisposes injury' supported by the sentence: 'A 66-year-old man was treated for IgD (lambda) multiple myeloma with 2mg/day melphalan and 20mg/day prednisolone.'?,"No, the statement does not provide any direct or indirect support for the phrase ""Ibuprofen predisposes injury."" The statement discusses a patient with multiple myeloma being treated with melphalan and prednisolone, but it does not mention ibuprofen or any injury associated with its use. + + To further elaborate on my response, let us consider some potential connections that might theoretically link ibuprofen, injury predisposition, and the information provided in the statement: + + 1) If the patient was also taking ibuprofen concurrently with melphalan and prednisolone, there could be potential drug interactions that might increase the risk of injury (e.g., gastrointestinal bleeding). However, since ibuprofen is not mentioned in the statement, we cannot draw any conclusions about its involvement in drug interactions. + + 2) If melphalan or prednisolone is known to increase injury risk when combined with ibuprofen use, one could argue that ibuprofen predisposes injury indirectly through interactions with these medications. However, there is no information in the statement suggesting that melphalan or prednisolone" +12673407,Ibuprofen predisposes bone fracture,175,"Moreover, after recent findings regarding the presence of endogenous prednisolone in the urine of more popular breeds, particular attention was given to analysis of the presence of prednisolone and prednisone, as well.",False,"Is the triple 'Ibuprofen predisposes bone fracture' supported by the sentence: 'Moreover, after recent findings regarding the presence of endogenous prednisolone in the urine of more popular breeds, particular attention was given to analysis of the presence of prednisolone and prednisone, as well.'?","No, the statement does not provide any direct or indirect support for the phrase ""Ibuprofen predisposes bone fracture"". The presence of endogenous prednisolone in urine has no known connection to ibuprofen predisposing bone fractures. Prednisolone is a corticosteroid hormone used in medicine for its anti-inflammatory effects, while ibuprofen is a non-steroidal anti-inflammatory drug (NSAID). There is no evidence in the statement that links ibuprofen usage to an increased risk of bone fractures through prednisolone or any other means." +17604344,Ivabradine related to diastolic heart failure,176,"Of 10 mg of prednisone given orally to 5 normal subjects, 69+/-5% was absorbed and converted to peripheral plasma prednisolone within 8 h.",False,"Is the triple 'Ivabradine related to diastolic heart failure' supported by the sentence: 'Of 10 mg of prednisone given orally to 5 normal subjects, 69+/-5% was absorbed and converted to peripheral plasma prednisolone within 8 h.'?","No, the statement does not provide any indirect support for the phrase ""Ivabradine related to diastolic heart failure"". The statement is about the pharmacokinetics of prednisone in normal subjects, while Ivabradine is a different drug used for treating heart failure, specifically chronic heart failure with reduced ejection fraction. The two statements are unrelated in subject matter and do not provide any supportive evidence for the claim about Ivabradine and diastolic heart failure." +19228519,Ivabradine causes atrial fibrillation,177,"As in humans, prednisolone was partly converted to prednisone in the rabbit.",False,"Is the triple 'Ivabradine causes atrial fibrillation' supported by the sentence: 'As in humans, prednisolone was partly converted to prednisone in the rabbit.'?","No, the statement does not provide any indirect support for the claim that Ivabradine causes atrial fibrillation. The two statements discuss different drugs (Ivabradine vs Prednisolone) and their effects on organisms (humans vs rabbits). The conversion process mentioned in the second statement is also unrelated to atrial fibrillation or any cardiac effects." +20784958,Ivabradine affects atrial fibrillation,178,"Given the close resemblance of the ring A structure of prednisolone and prednisone on the one hand, and of androstadienedione on the other, the transformation of cortisol and cortisone into prednisolone and prednisone in cattle faeces was evaluated.",False,"Is the triple 'Ivabradine affects atrial fibrillation' supported by the sentence: 'Given the close resemblance of the ring A structure of prednisolone and prednisone on the one hand, and of androstadienedione on the other, the transformation of cortisol and cortisone into prednisolone and prednisone in cattle faeces was evaluated.'?","No, the statement does not provide indirect support for the claim that ""Ivabradine affects atrial fibrillation"". The statement discusses the transformation of cortisol and cortisone into prednisolone and prednisone in cattle faeces, which is unrelated to Ivabradine and atrial fibrillation. Ivabradine is a medication used to treat heart failure and high blood pressure by reducing heart rate, while atrial fibrillation is an irregular heart rhythm. The two substances mentioned in the statement (prednisolone/prednisone and androstadienedione) also have no known direct connection to Ivabradine or atrial fibrillation. Therefore, there is no clear basis for inferring that Ivabradine affects atrial fibrillation based on this statement." +20520107,Ivabradine affects mitral valve stenosis,179,The data indicate that prednisone is extensively metabolized to prednisolone before it clears the splanchnic circulation and the formation prednisone by oxidation of the 11-hydorxyl group of prednisolone appears to occur mainly in peripheral tissues.,False,Is the triple 'Ivabradine affects mitral valve stenosis' supported by the sentence: 'The data indicate that prednisone is extensively metabolized to prednisolone before it clears the splanchnic circulation and the formation prednisone by oxidation of the 11-hydorxyl group of prednisolone appears to occur mainly in peripheral tissues.'?,"No, the statement does not provide any indirect support for the claim that Ivabradine affects mitral valve stenosis. The statement discusses prednisone metabolism, specifically its conversion to prednisolone in the splanchnic circulation and further oxidation in peripheral tissues. It does not mention Ivabradine or mitral valve stenosis at all. To evaluate the claim about Ivabradine affecting mitral valve stenosis, one would need evidence specifically related to Ivabradine and its impact on mitral valve stenosis." +20004006,Ivabradine affects diastolic heart failure,180,CONCLUSION: Dexamethasone or prednisolone were the easiest to induce steroid glaucoma when the patients had long-term use of steroid eyedrops.,False,Is the triple 'Ivabradine affects diastolic heart failure' supported by the sentence: 'CONCLUSION: Dexamethasone or prednisolone were the easiest to induce steroid glaucoma when the patients had long-term use of steroid eyedrops.'?,"No, the statement does not provide indirect support for the phrase ""Ivabradine affects diastolic heart failure"". The conclusion in the statement is about dexamethasone or prednisolone inducing steroid glaucoma in patients who have long-term use of steroid eyedrops. Ivabradine is a medication used for heart failure but it is not mentioned in the statement at all. Therefore, there is no connection between ivabradine and diastolic heart failure supported by this conclusion." +15323309,Ivabradine affects cardiovascular disorder,181,"Among 121 CK-analogs studied, CK-17, CK-101A and CK103A have been identified as promising anti-inflammatory agents as potent as prednisolone in inhibiting lens proteins-induced inflammation and twice as potent as prednisolone in inhibiting endotoxin-and IL-1-induced uveitis.",False,"Is the triple 'Ivabradine affects cardiovascular disorder' supported by the sentence: 'Among 121 CK-analogs studied, CK-17, CK-101A and CK103A have been identified as promising anti-inflammatory agents as potent as prednisolone in inhibiting lens proteins-induced inflammation and twice as potent as prednisolone in inhibiting endotoxin-and IL-1-induced uveitis.'?","No, the statement does not provide indirect support for the phrase ""Ivabradine affects cardiovascular disorder"". The statement discusses three compounds (CK-17, CK-101A, CK-103A) as potential anti-inflammatory agents in treating uveitis and lens proteins-induced inflammation, but it does not mention Ivabradine nor any cardiovascular disorders. Ivabradine is a medication used primarily for heart rate reduction in patients with cardiovascular diseases; thus, its effects on cardiovascular disorders would need separate evaluation based on appropriate studies involving Ivabradine itself." +15323306,Ivabradine affects coronary artery disorder,182,Light and electron microscopy of prednisolone-induced nephropathy in rabbits.,False,Is the triple 'Ivabradine affects coronary artery disorder' supported by the sentence: 'Light and electron microscopy of prednisolone-induced nephropathy in rabbits.'?,"No, the statement ""Light and electron microscopy of prednisolone-induced nephropathy in rabbits"" does not provide indirect support for the claim that ""Ivabradine affects coronary artery disorder"". + + The statement describes a study examining prednisolone-induced nephropathy in rabbits using light and electron microscopy techniques. Nephropathy refers to kidney disease or damage, while prednisolone is a type of corticosteroid medication often used to treat inflammation. The study does not mention Ivabradine, which is a drug used primarily for heart rhythm disorders (such as atrial fibrillation), heart failure, or certain types of angina (chest pain). Furthermore, coronary artery disorder refers to conditions that affect the coronary arteries (vessels supplying blood to the heart muscle), such as coronary artery disease (CAD). + + The lack of connection between prednisolone-induced nephropathy in rabbits and Ivabradine's effects on coronary artery disorder renders the provided statement unrelated to the claim in question." +19514713,Ivabradine disrupts atrial fibrillation,183,The behavior results showed that exposure to prednisolone resulted in decreased autonomic activity and low sensitivity to light.,False,Is the triple 'Ivabradine disrupts atrial fibrillation' supported by the sentence: 'The behavior results showed that exposure to prednisolone resulted in decreased autonomic activity and low sensitivity to light.'?,"No, the statement does not provide indirect support for the phrase ""Ivabradine disrupts atrial fibrillation."" The two statements refer to different substances (Ivabradine and prednisolone) and different physiological processes (atrial fibrillation and autonomic activity/light sensitivity). Therefore, there is no clear connection between them that would allow us to infer support for the disruption of atrial fibrillation by Ivabradine based on the provided information about prednisolone's effects on autonomic activity and light sensitivity." +17909104,Ivabradine disrupts coronary artery disorder,184,We therefore advocate for increased clinical alertness towards prednisolone-induced adrenal insufficiency in RTx patients and thus their potential need of rescue GC supplementation during stress.,False,Is the triple 'Ivabradine disrupts coronary artery disorder' supported by the sentence: 'We therefore advocate for increased clinical alertness towards prednisolone-induced adrenal insufficiency in RTx patients and thus their potential need of rescue GC supplementation during stress.'?,"No, the statement does not provide indirect support for the phrase ""Ivabradine disrupts coronary artery disorder"". The statement is discussing prednisolone-induced adrenal insufficiency in renal transplant (RTx) patients and the potential need for rescue glucocorticoid (GC) supplementation during stressful situations. This topic is unrelated to ivabradine and coronary artery disorder. Ivabradine is a medication used primarily for heart rate control in certain conditions like chronic heart failure, but it does not disrupt coronary artery disorder. Therefore, there is no connection between these two pieces of information." +17822394,Ivabradine prevents atrial fibrillation,185,Zeaxanthin (50 mg/kg/day) or prednisolone (5 mg/kg/day) was orally administered for 14 days before induction of ulcerative colitis.,False,Is the triple 'Ivabradine prevents atrial fibrillation' supported by the sentence: 'Zeaxanthin (50 mg/kg/day) or prednisolone (5 mg/kg/day) was orally administered for 14 days before induction of ulcerative colitis.'?,"No, the statement does not provide indirect support for the claim that Ivabradine prevents atrial fibrillation. The substances mentioned in the statement, Zeaxanthin and prednisolone, have no direct relationship or shared mechanism with Ivabradine that would suggest it has any influence on atrial fibrillation prevention. Additionally, ulcerative colitis induction is unrelated to atrial fibrillation; therefore, any effects observed would not translate to atrial fibrillation prevention by Ivabradine." +10817471,Ivabradine prevents Tachycardia,186,"OBJECTIVE: We want to show that an intralesional injection of prednisolone into the proximal nail fold may produce dorsal pain, dyspnoea and headaches within the 2 min following the injection and to explain the pathophysiology of his condition.",False,"Is the triple 'Ivabradine prevents Tachycardia' supported by the sentence: 'OBJECTIVE: We want to show that an intralesional injection of prednisolone into the proximal nail fold may produce dorsal pain, dyspnoea and headaches within the 2 min following the injection and to explain the pathophysiology of his condition.'?","No, the statement does not provide indirect support for the claim that ""Ivabradine prevents Tachycardia"". The objective in the statement is focused on demonstrating the effects of an intralesional injection of prednisolone on various symptoms such as dorsal pain, dyspnoea (shortness of breath), and headaches within 2 minutes following injection. The statement does not mention Ivabradine at all, let alone its potential in preventing tachycardia (a rapid heart rate). Therefore, there is no connection between these two pieces of information that would allow us to infer support for the claim about Ivabradine." +19153602,Ivabradine predisposes atrial fibrillation,187,[A case of nephrotic syndrome with abnormally high level of protein C induced by prednisolone].,False,Is the triple 'Ivabradine predisposes atrial fibrillation' supported by the sentence: '[A case of nephrotic syndrome with abnormally high level of protein C induced by prednisolone].'?,"No, the statement does not provide any indirect support for the phrase ""Ivabradine predisposes atrial fibrillation."" The statement discusses a case of nephrotic syndrome induced by prednisolone, which is an unrelated glucocorticoid medication used primarily for its anti-inflammatory effects. Ivabradine is a different medication primarily used for heart rate reduction in patients with chronic heart failure or stable angina pectoris. + + The two medications have different mechanisms of action; prednisolone affects inflammation by modulating gene expression through nuclear factor-kappa B (NF-κB) pathways while ivabradine selectively inhibits the ""funny"" current (I(f)) in the sinoatrial node cells to reduce heart rate without affecting myocardial contractility or conduction velocity. + + Furthermore, there is no mention of atrial fibrillation (AFib) in the provided statement. AFib is an abnormal heart rhythm originating in the atria that can lead to palpitations, shortness of breath, and even stroke if left untreated. Although ivabradine is associated with bradycardia" +15385004,Cefixime affects chronic bronchitis,188,It is concluded that six or more cycles of COPP chemotherapy for advanced Hodgkin's disease in men leads to permanent sterility.,False,Is the triple 'Cefixime affects chronic bronchitis' supported by the sentence: 'It is concluded that six or more cycles of COPP chemotherapy for advanced Hodgkin's disease in men leads to permanent sterility.'?,"No, the statement does not provide any indirect support for the phrase ""Cefixime affects chronic bronchitis."" The conclusion drawn in the statement is about the impact of COPP chemotherapy on fertility in men with advanced Hodgkin's disease. Cefixime is an antibiotic used to treat various bacterial infections and has no direct relation to chronic bronchitis or chemotherapy-induced sterility." +15252860,Cefixime affects gonorrhea,189,The erythroderma improved generally as a result of systemic prednisolone treatment.,False,Is the triple 'Cefixime affects gonorrhea' supported by the sentence: 'The erythroderma improved generally as a result of systemic prednisolone treatment.'?,"No, the statement ""The erythroderma improved generally as a result of systemic prednisolone treatment"" does not provide indirect support for the phrase ""Cefixime affects gonorrhea"". + + The improvement of erythroderma (a severe form of skin inflammation) due to systemic prednisolone treatment is related to the therapeutic effects of prednisolone, a corticosteroid used in treating various inflammatory conditions. This information does not make any mention of Cefixime, an antibiotic commonly used to treat infections such as gonorrhea. + + Furthermore, there is no explicit or implicit connection between prednisolone treatment for skin inflammation and Cefixime's potential effects on gonorrhea. Therefore, it is not reasonable to infer support for the statement ""Cefixime affects gonorrhea"" based on the provided information about prednisolone treatment for erythroderma." +18811968,Cefixime prevents otitis media,190,CONTACT DERMATITIS DUE TO TOPICAL HYDROCORTISONE AND PREDNISOLONE.,False,Is the triple 'Cefixime prevents otitis media' supported by the sentence: 'CONTACT DERMATITIS DUE TO TOPICAL HYDROCORTISONE AND PREDNISOLONE.'?,"No, the statement ""CONTACT DERMATITIS DUE TO TOPICAL HYDROCORTISONE AND PREDNISOLONE"" does not provide indirect support for the claim that ""Cefixime prevents otitis media."" + + The statement is about contact dermatitis caused by topical application of hydrocortisone and prednisolone, which is not related to otitis media (middle ear infection) or Cefixime (an antibiotic used for treating various bacterial infections). Therefore, there is no logical connection between these two statements that would allow for indirect support from one to the other in terms of their respective contents." +17748395,Trimetazidine related to diabetic kidney disease,191,[Pulmonary tuberculosis due to prednisolone].,False,Is the triple 'Trimetazidine related to diabetic kidney disease' supported by the sentence: '[Pulmonary tuberculosis due to prednisolone].'?,"No, the statement ""Pulmonary tuberculosis due to prednisolone"" does not provide indirect support for the phrase ""Trimetazidine related to diabetic kidney disease"". This is because prednisolone is a corticosteroid medication used for various conditions such as inflammation and allergies, while Trimetazidine is primarily used in treating angina pectoris (chest pain) due to coronary artery disease. Diabetic kidney disease is a complication associated with diabetes mellitus, and there is no direct or indirect connection between prednisolone-induced pulmonary tuberculosis and Trimetazidine-related diabetic kidney disease based on the given statement." +22426756,Trimetazidine affects diabetic kidney disease,192,"Rats were treated with a leukotriene synthesis inhibitor (PF-5901), a leukotriene B4 receptor antagonist (SC-41930), an IL-1 receptor antagonist or a corticosteroid (prednisolone) prior to induction of colitis.",False,"Is the triple 'Trimetazidine affects diabetic kidney disease' supported by the sentence: 'Rats were treated with a leukotriene synthesis inhibitor (PF-5901), a leukotriene B4 receptor antagonist (SC-41930), an IL-1 receptor antagonist or a corticosteroid (prednisolone) prior to induction of colitis.'?","No, the statement does not provide any direct or indirect support for the claim that Trimetazidine affects diabetic kidney disease. The provided statement discusses various treatments given to rats before induction of colitis, which is unrelated to diabetic kidney disease or Trimetazidine treatment. To evaluate whether Trimetazidine affects diabetic kidney disease, studies involving Trimetazidine administration in diabetic kidney disease models would be required." +21297588,Trimetazidine affects Cardiotoxicity,193,"PURPOSE: To investigate the relationship between vitamin E deficiency and prednisolone-induced cataract formation, long-term examination of lens changes was performed in rats under the condition of vitamin E deficiency or supplementation and administration of prednisolone.",False,"Is the triple 'Trimetazidine affects Cardiotoxicity' supported by the sentence: 'PURPOSE: To investigate the relationship between vitamin E deficiency and prednisolone-induced cataract formation, long-term examination of lens changes was performed in rats under the condition of vitamin E deficiency or supplementation and administration of prednisolone.'?","No, the statement does not provide indirect support for the claim that Trimetazidine affects Cardiotoxicity. The purpose statement is about an investigation into vitamin E deficiency and prednisolone-induced cataract formation in rats, which is unrelated to Trimetazidine or cardiotoxicity. The two subjects are distinct and there is no overlap in their respective areas of study." +19164679,Trimetazidine affects cardiovascular disorder,194,"In inactive SLE induced by prednisolone therapy, the invariant Valpha24JalphaQ TCR could be detected in DN Valpha24+ T cells from all the patients and dominated in most of the patients.",False,"Is the triple 'Trimetazidine affects cardiovascular disorder' supported by the sentence: 'In inactive SLE induced by prednisolone therapy, the invariant Valpha24JalphaQ TCR could be detected in DN Valpha24+ T cells from all the patients and dominated in most of the patients.'?","No, the statement does not provide any direct or indirect support for the claim that Trimetazidine affects cardiovascular disorder. The statement discusses the presence and dominance of invariant Valpha24JalphaQ TCR in DN Valpha24+ T cells in patients under prednisolone therapy for inactive Systemic Lupus Erythematosus (SLE). This information is not related to Trimetazidine or its effects on cardiovascular disorders." +18547788,Trimetazidine prevents Cardiotoxicity,195,"Interleukin-1 (IL-1) blockers, CK 127 and CK 129, were found to inhibit IL-1-induced posterior uveitis very effectively at 3-10 mg/kg i.p. and were more potent than prednisolone which required at least 20 mg/kg i.p. to achieve the same level of anti-uveitis action.",False,"Is the triple 'Trimetazidine prevents Cardiotoxicity' supported by the sentence: 'Interleukin-1 (IL-1) blockers, CK 127 and CK 129, were found to inhibit IL-1-induced posterior uveitis very effectively at 3-10 mg/kg i.p. and were more potent than prednisolone which required at least 20 mg/kg i.p. to achieve the same level of anti-uveitis action.'?","No, the statement does not provide indirect support for the claim that Trimetazidine prevents cardiotoxicity. The two statements discuss different subjects: one is about interleukin-1 blockers (CK 127 and CK 129) inhibiting IL-1-induced posterior uveitis in an animal model, while the other would be about Trimetazidine preventing cardiotoxicity in humans or animal models. + + Even if we consider that both statements involve therapeutic interventions in diseases (cardiotoxicity in one case and uveitis in another), there is no overlap in terms of mechanisms, drug compounds, or disease models that would justify inferring any relationship between them. + + In order for the first statement to provide indirect support for the second statement, it would need to involve similar disease mechanisms (e.g., inflammation), share drug compounds (Trimetazidine being an interleukin-1 blocker), or demonstrate similar protective effects in related disease models (e.g., cardiotoxicity models instead of uveitis models). Since none of these connections exist between the two statements, it is not appropriate to infer any relationship between" +13317799,Ranolazine causes atrial fibrillation,196,[A case of hormone-refractory prostate cancer responsive to low-dose prednisolone therapy].,False,Is the triple 'Ranolazine causes atrial fibrillation' supported by the sentence: '[A case of hormone-refractory prostate cancer responsive to low-dose prednisolone therapy].'?,"No, the statement does not provide indirect support for the claim that ""Ranolazine causes atrial fibrillation."" The statement discusses a case of hormone-refractory prostate cancer responsive to low-dose prednisolone therapy, which has no direct relevance or connection to Ranolazine or atrial fibrillation. Therefore, it does not offer any evidence or reasoning that would lead one to infer that Ranolazine causes atrial fibrillation." +19314329,Ranolazine affects cardiovascular disorder,197,6 cases of FSGS had poor response to any therapy; 7 cases were responsive to either triple therapy or cyclosporine A plus prednisolone.,False,Is the triple 'Ranolazine affects cardiovascular disorder' supported by the sentence: '6 cases of FSGS had poor response to any therapy; 7 cases were responsive to either triple therapy or cyclosporine A plus prednisolone.'?,"No, the statement does not provide indirect support for the phrase ""Ranolazine affects cardiovascular disorder"". The statement discusses two groups of patients with FSGS (Focal Segmental Glomerulosclerosis) who had different responses to various therapies including triple therapy and cyclosporine A plus prednisolone. Ranolazine is not mentioned in the statement at all, hence it cannot lend support to any claim about its effects on cardiovascular disorder." +19002641,Ranolazine affects atrial fibrillation,198,"From 1983, exacerbation of PIE was recorded three times, on which occasions prednisolone and antibiotics were quite effective.",False,"Is the triple 'Ranolazine affects atrial fibrillation' supported by the sentence: 'From 1983, exacerbation of PIE was recorded three times, on which occasions prednisolone and antibiotics were quite effective.'?","No, the statement does not provide indirect support for the phrase ""Ranolazine affects atrial fibrillation."" The statement discusses instances where prednisolone and antibiotics were effective in treating exacerbations of PIE (pericardial inflammatory effusion) in 1983. Ranolazine is not mentioned in the statement; therefore, there is no connection that can be inferred between Ranolazine and atrial fibrillation from this information alone. + + To establish indirect support for the claim about Ranolazine affecting atrial fibrillation using this statement, additional information would be needed that links PIE treatments, such as prednisolone and antibiotics, to Ranolazine usage and atrial fibrillation incidence or severity. Since no such link is provided in the given statement, it cannot offer indirect support for the claim in question." +17881291,Ranolazine affects type 2 diabetes mellitus,199,"A comparative study of the effects of ACTH, hydrocortisone and prednisolone in the hypersensitive reactions produced with the protein components of Hymenolepis nana in albino mice.",False,"Is the triple 'Ranolazine affects type 2 diabetes mellitus' supported by the sentence: 'A comparative study of the effects of ACTH, hydrocortisone and prednisolone in the hypersensitive reactions produced with the protein components of Hymenolepis nana in albino mice.'?","No, the statement does not provide any direct or indirect support for the claim that ""Ranolazine affects type 2 diabetes mellitus."" The study referenced is focused on the effects of ACTH, hydrocortisone, and prednisolone in hypersensitive reactions produced by protein components of Hymenolepis nana in albino mice. There is no mention or implication of Ranolazine or type 2 diabetes mellitus in this study. Therefore, it does not contribute to our understanding or validation of that specific claim." +16599546,Ranolazine affects atrial fibrillation,200,"Immunosuppressant therapy, such as prednisolone or azathioprine, is considered for exacerbations of highly active glomerulonephritis.",False,"Is the triple 'Ranolazine affects atrial fibrillation' supported by the sentence: 'Immunosuppressant therapy, such as prednisolone or azathioprine, is considered for exacerbations of highly active glomerulonephritis.'?","No, the statement does not provide any direct or indirect support for the phrase ""Ranolazine affects atrial fibrillation."" The statement discusses immunosuppressant therapy as an option for managing highly active glomerulonephritis exacerbations, which is unrelated to Ranolazine and its potential effects on atrial fibrillation." +15199166,Ranolazine affects myocardial ischemia,201,"We describe a 57-year-old Caucasian male with anti-MDA5 positive dermatomyositis, that had a 4-month history of progressive dyspnoea requiring oxygen-therapy, scarcely responsive to prednisolone.",False,"Is the triple 'Ranolazine affects myocardial ischemia' supported by the sentence: 'We describe a 57-year-old Caucasian male with anti-MDA5 positive dermatomyositis, that had a 4-month history of progressive dyspnoea requiring oxygen-therapy, scarcely responsive to prednisolone.'?","No, the statement does not provide direct or indirect support for the phrase ""Ranolazine affects myocardial ischemia."" The statement discusses a patient case report about a 57-year-old male suffering from dermatomyositis who experienced progressive dyspnoea despite prednisolone treatment; however, it does not mention Ranolazine or its effects on myocardial ischemia. + + To better assess whether Ranolazine affects myocardial ischemia, one should look at experimental studies investigating its impact on myocardial ischemia outcomes specifically. This would provide more solid evidence in favor of (or against) that claim." +13887428,Ranolazine disrupts atrial fibrillation,202,"After 14 months of treatment one of the patients developed severe, acute exacerbation of the ABPA and was treated with high-dose prednisolone and local steroid.",False,"Is the triple 'Ranolazine disrupts atrial fibrillation' supported by the sentence: 'After 14 months of treatment one of the patients developed severe, acute exacerbation of the ABPA and was treated with high-dose prednisolone and local steroid.'?","No, the statement does not provide any direct or indirect support for the claim that ""Ranolazine disrupts atrial fibrillation."" The information given pertains to a patient's treatment for acute exacerbation of allergic bronchopulmonary aspergillosis (ABPA) using high-dose prednisolone and local steroid, which has no discernible connection to atrial fibrillation or its disruption by Ranolazine. + + To further clarify, Ranolazine is primarily used in treating chronic angina by inhibiting late sodium current in cardiac myocytes. While there have been some studies suggesting its potential in managing atrial fibrillation through its antiarrhythmic properties, the given statement does not offer any evidence linking Ranolazine specifically to atrial fibrillation disruption. + + It is essential in interpreting scientific evidence and statements that causality is clearly established through well-designed experiments and proper controls. The statement provided here does not meet these criteria for implying any connection between Ranolazine usage and atrial fibrillation disruption." +17475563,Ranolazine prevents Angina pectoris,203,"The effect of pretreatment with topical prostaglandin E2, prednisolone and sulphasalazine in experimental colitis has been examined in the rat colon.",False,"Is the triple 'Ranolazine prevents Angina pectoris' supported by the sentence: 'The effect of pretreatment with topical prostaglandin E2, prednisolone and sulphasalazine in experimental colitis has been examined in the rat colon.'?","No, the statement does not provide any direct or indirect support for the claim that ""Ranolazine prevents Angina pectoris"". The experiment mentioned in the statement was conducted on rat colons using topical prostaglandin E2, prednisolone and sulphasalazine, which are not related to Ranolazine or Angina pectoris in any way. Therefore, it does not contribute to our understanding or validation of the claim about Ranolazine preventing Angina pectoris." +14751648,Ranolazine prevents myocardial ischemia,204,"Here, we report a case of prednisolone-dependent gastric sarcoidosis that improved after additional azathioprine, and also review the literature concerning the treatment, especially for prednisolone-dependent cases.",False,"Is the triple 'Ranolazine prevents myocardial ischemia' supported by the sentence: 'Here, we report a case of prednisolone-dependent gastric sarcoidosis that improved after additional azathioprine, and also review the literature concerning the treatment, especially for prednisolone-dependent cases.'?","No, the statement does not provide any direct or indirect support for the claim that ""Ranolazine prevents myocardial ischemia"". The statement discusses a case of prednisolone-dependent gastric sarcoidosis that improved after additional azathioprine treatment and reviews literature related to treatment, specifically for prednisolone-dependent cases. The drug Ranolazine is not mentioned nor is there any information linking it to myocardial ischemia prevention in this context." +14280230,Ranolazine prevents atrial fibrillation,205,"METHODS: In 126 adults (33 healthy control subjects, 31 patients with mild asthma, 32 patients with severe asthma, and 30 patients with prednisolone-dependent asthma) parameters of inflammation (peripheral blood eosinophils and neutrophils) and markers of hemostasis (endogenous thrombin potential [ETP], thrombin-antithrombin complex, plasmin-alpha2-antiplasmin complex, plasminogen activator inhibitor type 1 [PAI-1], D-dimer, and von Willebrand factor [vWF]) were measured in plasma.",False,"Is the triple 'Ranolazine prevents atrial fibrillation' supported by the sentence: 'METHODS: In 126 adults (33 healthy control subjects, 31 patients with mild asthma, 32 patients with severe asthma, and 30 patients with prednisolone-dependent asthma) parameters of inflammation (peripheral blood eosinophils and neutrophils) and markers of hemostasis (endogenous thrombin potential [ETP], thrombin-antithrombin complex, plasmin-alpha2-antiplasmin complex, plasminogen activator inhibitor type 1 [PAI-1], D-dimer, and von Willebrand factor [vWF]) were measured in plasma.'?","No, the statement does not provide indirect support for the claim that ""Ranolazine prevents atrial fibrillation."" The study mentioned measures various inflammation parameters and markers of hemostasis in different groups of patients including healthy controls, but it does not mention anything about Ranolazine or atrial fibrillation in its methods section. Therefore, there is no basis for inferring any relationship between Ranolazine and atrial fibrillation based on this information alone." +17988674,Ranolazine predisposes atrial fibrillation,206,Previous studies from our laboratory revealed that coadministration of EP significantly increased the plasma concentration of prednisolone while decreased the level of cotreated prednisone in rats.,False,Is the triple 'Ranolazine predisposes atrial fibrillation' supported by the sentence: 'Previous studies from our laboratory revealed that coadministration of EP significantly increased the plasma concentration of prednisolone while decreased the level of cotreated prednisone in rats.'?,"No, the statement does not provide indirect support for the phrase ""Ranolazine predisposes atrial fibrillation."" The statement discusses changes in plasma concentration following coadministration of two substances (EP and prednisolone/prednisone) in rats, but it does not mention nor imply any effects on atrial fibrillation nor does it mention Ranolazine. The two subjects (pharmacokinetic interactions and atrial fibrillation) are unrelated in this context. + + To establish a connection between the two statements, there would need to be evidence linking Ranolazine to changes in plasma concentration of substances known to predispose atrial fibrillation or direct evidence showing that Ranolazine itself increases atrial fibrillation risk in individuals. In the absence of such evidence, it is unwarranted to make such an association between the two statements." +26862829,Prednisolone related to multiple sclerosis,207,Metabolic effects of high-dose prednisolone treatment in early rheumatoid arthritis: balance between diabetogenic effects and inflammation reduction.,False,Is the triple 'Prednisolone related to multiple sclerosis' supported by the sentence: 'Metabolic effects of high-dose prednisolone treatment in early rheumatoid arthritis: balance between diabetogenic effects and inflammation reduction.'?,"No, the statement does not provide indirect support for the phrase ""Prednisolone related to multiple sclerosis."" The study referenced in the statement investigates the metabolic effects of high-dose prednisolone treatment in early rheumatoid arthritis patients, focusing on diabetogenic effects and inflammation reduction. Multiple sclerosis is an entirely different disease entity from rheumatoid arthritis, and no information regarding multiple sclerosis is provided in the statement. Therefore, it is inappropriate to infer any connection between prednisolone use and multiple sclerosis based solely on this information." +26365803,Prednisolone related to adrenocortical insufficiency,208,"Effects of prednisolone, salbutamol and theophylline on bronchial hyperreactivity and leucocyte chemokinesis in guinea pigs.",False,"Is the triple 'Prednisolone related to adrenocortical insufficiency' supported by the sentence: 'Effects of prednisolone, salbutamol and theophylline on bronchial hyperreactivity and leucocyte chemokinesis in guinea pigs.'?","No, the statement ""Effects of prednisolone, salbutamol and theophylline on bronchial hyperreactivity and leucocyte chemokinesis in guinea pigs"" does not provide indirect support for the phrase ""Prednisolone related to adrenocortical insufficiency"". + + The statement discusses an experiment conducted on guinea pigs, where prednisolone is used along with salbutamol and theophylline. The focus of the study is on bronchial hyperreactivity and leucocyte chemokinesis, which are immune responses typically associated with asthma or allergies rather than adrenocortical insufficiency. + + Adrenocortical insufficiency (also known as Addison's disease) is characterized by impaired production of cortisol from the adrenal glands. Prednisolone is a synthetic glucocorticoid often used as replacement therapy in cases where adrenal insufficiency is present; however, its use in healthy individuals can suppress the natural cortisol production in the adrenal glands. + + In summary, while prednisolone can" +26295217,Prednisolone related to angioimmunoblastic T-cell lymphoma,209,"This is the first case to support the beneficial effect of prednisolone in pericarditis with pSS, and illustrates its safety during pregnancy.",False,"Is the triple 'Prednisolone related to angioimmunoblastic T-cell lymphoma' supported by the sentence: 'This is the first case to support the beneficial effect of prednisolone in pericarditis with pSS, and illustrates its safety during pregnancy.'?","No, the statement does not provide indirect support for the phrase ""Prednisolone related to angioimmunoblastic T-cell lymphoma."" The statement discusses the beneficial effect and safety of prednisolone in pericarditis with primary Sjogren's syndrome (pSS) during pregnancy, but it does not mention nor imply any connection between prednisolone and angioimmunoblastic T-cell lymphoma. + + Angioimmunoblastic T-cell lymphoma is a rare form of non-Hodgkin lymphoma that can be associated with autoimmune diseases like pSS; however, there is no mention of such an association in this particular statement. Therefore, it is inappropriate to infer any relationship between prednisolone use and angioimmunoblastic T-cell lymphoma based on this information alone." +26194122,Prednisolone related to synovitis,210,"When combined with environmental control, prednisolone and dexamethasone treatments had similar effects on heaves score, blood gases and endoscopic scores.",False,"Is the triple 'Prednisolone related to synovitis' supported by the sentence: 'When combined with environmental control, prednisolone and dexamethasone treatments had similar effects on heaves score, blood gases and endoscopic scores.'?","No, the phrase ""Prednisolone related to synovitis"" does not receive direct or indirect support from the statement provided. The statement discusses the effects of prednisolone and dexamethasone on heaves score, blood gases, and endoscopic scores in an unspecified context (possibly related to heaves in horses). However, synovitis is not mentioned anywhere in the statement. Synovitis is inflammation of the synovial membrane which lines joint capsules and tendon sheaths; it is not directly related to heaves in horses or blood gases. Therefore, there is no basis for connecting prednisolone use in this context to synovitis based on the given statement alone." +25959730,Prednisolone related to sarcoma,211,"Of the 20 patients, 14 initially received prednisolone treatment, which resulted in rapid improvement and normalization of eosinophilia within 8 weeks; however, 2 patients with splenomegaly showed poor control of eosinophilia in response to corticosteroid treatment.",False,"Is the triple 'Prednisolone related to sarcoma' supported by the sentence: 'Of the 20 patients, 14 initially received prednisolone treatment, which resulted in rapid improvement and normalization of eosinophilia within 8 weeks; however, 2 patients with splenomegaly showed poor control of eosinophilia in response to corticosteroid treatment.'?","No, the statement does not provide direct or indirect support for the phrase ""Prednisolone related to sarcoma"". The statement discusses the effects of prednisolone on eosinophilia in patients but does not mention sarcoma at all. Sarcoma is a type of cancer that originates in connective tissue such as bone, cartilage, fat, muscle, blood vessels, or other supportive tissue. The evidence presented in the statement is not relevant to making any conclusions about whether prednisolone has any connection to sarcoma." +25621708,Prednisolone related to uveitis,212,Complement activation capacity in plasma before and during high-dose prednisolone treatment and tapering in exacerbations of Crohn's disease and ulcerative colitis.,True,Is the triple 'Prednisolone related to uveitis' supported by the sentence: 'Complement activation capacity in plasma before and during high-dose prednisolone treatment and tapering in exacerbations of Crohn's disease and ulcerative colitis.'?,"Yes, indirectly it does provide some support for the association between Prednisolone and uveitis. The statement discusses high-dose prednisolone treatment in exacerbations of Crohn's disease and ulcerative colitis. Prednisolone is a corticosteroid often used to treat inflammatory conditions such as these. Uveitis is also an inflammatory condition, specifically affecting the eye. Therefore, there could be a connection between Prednisolone use and uveitis due to their common involvement in inflammatory responses. However, it is important to note that this paper does not directly study or mention uveitis, so it does not provide direct evidence. It simply suggests a potential indirect link through their shared involvement in inflammation." +24523226,Prednisolone related to glomerulonephritis,213,Prednisolone-responsive headache in patients with solitary cysticercus granuloma and seizures.,False,Is the triple 'Prednisolone related to glomerulonephritis' supported by the sentence: 'Prednisolone-responsive headache in patients with solitary cysticercus granuloma and seizures.'?,"No, the statement ""Prednisolone-responsive headache in patients with solitary cysticercus granuloma and seizures"" does not provide indirect support for the claim ""Prednisolone related to glomerulonephritis."" + + + The statement discusses prednisolone as a treatment for headaches in patients with solitary cysticercus granuloma and seizures. It does not mention glomerulonephritis or any renal-related issues. Glomerulonephritis is a condition characterized by inflammation in the glomeruli (a part of the kidney responsible for filtering waste from blood). Prednisolone is a type of corticosteroid that can be used to suppress inflammation in various conditions; however, it does not necessarily imply that prednisolone is related to glomerulonephritis in any way. + + + It is important to base conclusions on evidence that specifically addresses the claim in question; therefore, without any mention of glomerulonephritis in relation to prednisolone in the given statement, it does not lend support for such a claim." +23496152,Prednisolone related to subacute thyroiditis,214,"The patient was treated with chemotherapy by cyclophosphamide, hydroxydoxorubicin, vincristine and prednisolone (CHOP), however, it was ineffective, and the patient died of hemorrhage from the lymphoma involvement of the intestine 5 months after the onset of disease.",False,"Is the triple 'Prednisolone related to subacute thyroiditis' supported by the sentence: 'The patient was treated with chemotherapy by cyclophosphamide, hydroxydoxorubicin, vincristine and prednisolone (CHOP), however, it was ineffective, and the patient died of hemorrhage from the lymphoma involvement of the intestine 5 months after the onset of disease.'?","No, the statement does not provide indirect support for the phrase ""Prednisolone related to subacute thyroiditis."" The information given relates to a patient receiving chemotherapy treatment involving cyclophosphamide, hydroxydoxorubicin, vincristine, and prednisolone (CHOP) for lymphoma, but it does not mention any connection between prednisolone and subacute thyroiditis in this context. + + The statement highlights that chemotherapy was ineffective in treating the patient's lymphoma, which led to their unfortunate demise due to intestinal hemorrhage caused by lymphoma involvement. Prednisolone is part of the chemotherapy regimen; however, there is no indication regarding its specific effect on subacute thyroiditis in this case. + + Subacute thyroiditis is an inflammatory disorder that can be associated with certain treatments like interferon-alpha and amiodarone; however, prednisolone is not typically related to subacute thyroiditis as demonstrated by available literature and evidence-based guidelines (Bahn et al., 2015). + + In" +22194722,Prednisolone related to pulmonary eosinophilia,215,Effect of prednisolone in the experimentally induced nephropathy in male albino rats.,False,Is the triple 'Prednisolone related to pulmonary eosinophilia' supported by the sentence: 'Effect of prednisolone in the experimentally induced nephropathy in male albino rats.'?,"No, the statement ""Effect of prednisolone in the experimentally induced nephropathy in male albino rats"" does not provide indirect support for the phrase ""Prednisolone related to pulmonary eosinophilia."" The experiment conducted on male albino rats investigates the effect of prednisolone on nephropathy (kidney disease), not pulmonary eosinophilia (a condition involving an increased number of eosinophils in lung tissue). Therefore, there is no connection between prednisolone and pulmonary eosinophilia in this context. + + + + However, it is important to note that prednisolone is a glucocorticoid medication that can have immunosuppressive effects on various parts of the body, including lungs. In some instances, glucocorticoids like prednisolone might be prescribed for treating pulmonary eosinophilia indirectly by modulating immune system activity in the lungs. Nevertheless, based on the provided statement alone, there is no evidence supporting such a relationship between prednisolone and pulmonary eosinophilia" +21911849,Prednisolone related to habitual spontaneous abortion,216,[On the effect of oral use of prednisolone on central chorioretinitis].,False,Is the triple 'Prednisolone related to habitual spontaneous abortion' supported by the sentence: '[On the effect of oral use of prednisolone on central chorioretinitis].'?,"No, the statement ""On the effect of oral use of prednisolone on central chorioretinitis"" does not provide indirect support for the phrase ""Prednisolone related to habitual spontaneous abortion."" The provided statement is about the effect of prednisolone on central chorioretinitis, an eye condition, which is unrelated to spontaneous abortion. Therefore, it does not offer any relevant context or evidence that would lend credence to such a claim about prednisolone being related to habitual spontaneous abortion." +20512112,Prednisolone related to castration-resistant prostate carcinoma,217,Peptic ulceration associated with prednisolone therapy.,False,Is the triple 'Prednisolone related to castration-resistant prostate carcinoma' supported by the sentence: 'Peptic ulceration associated with prednisolone therapy.'?,"No, the statement ""Peptic ulceration associated with prednisolone therapy"" does not provide indirect support for the phrase ""Prednisolone related to castration-resistant prostate carcinoma"". + + These two statements discuss different aspects of prednisolone therapy. The first statement discusses an adverse effect (peptic ulceration) associated with prednisolone therapy, while the second statement pertains to a potential association between prednisolone and castration-resistant prostate carcinoma (CRPC). + + Although both statements relate to prednisolone use, they do not offer any implicit connection between prednisolone and CRPC. To establish indirect support for ""Prednisolone related to castration-resistant prostate carcinoma"", there should be some evidence suggesting that prednisolone has an impact on prostate cancer or its progression, which is not provided in the initial statement about peptic ulceration." +20312000,Prednisolone related to chronic primary adrenal insufficiency,218,"Glucocorticoids (e.g. prednisolone) are cornerstones in the treatment of acute exacerbations of ulcerative colitis (UC), and influence of the leucocyte/endothelial interaction appears to be part of their mode of action.",False,"Is the triple 'Prednisolone related to chronic primary adrenal insufficiency' supported by the sentence: 'Glucocorticoids (e.g. prednisolone) are cornerstones in the treatment of acute exacerbations of ulcerative colitis (UC), and influence of the leucocyte/endothelial interaction appears to be part of their mode of action.'?","No, the statement does not provide direct or indirect support for the phrase ""Prednisolone related to chronic primary adrenal insufficiency."" The provided assertion discusses glucocorticoids (including prednisolone) as part of ulcerative colitis (UC) treatment, focusing on their impact on leukocyte-endothelial interaction as a mode of action for acute exacerbations management. It does not mention chronic primary adrenal insufficiency nor suggest any connection between prednisolone and that condition." +20106181,Prednisolone related to allergic bronchopulmonary aspergillosis,219,"Effects of honey, prednisolone, and disulfiram on inflammation, nitric oxide, and free radical formation.",False,"Is the triple 'Prednisolone related to allergic bronchopulmonary aspergillosis' supported by the sentence: 'Effects of honey, prednisolone, and disulfiram on inflammation, nitric oxide, and free radical formation.'?","No, the statement ""Effects of honey, prednisolone, and disulfiram on inflammation, nitric oxide, and free radical formation"" does not provide direct or indirect support for the phrase ""Prednisolone related to allergic bronchopulmonary aspergillosis."" + + + The statement discusses the general effects of honey, prednisolone, and disulfiram on inflammation, nitric oxide, and free radical formation. However, it does not mention or imply any connection between prednisolone and allergic bronchopulmonary aspergillosis specifically. + + + Allergic bronchopulmonary aspergillosis (ABPA) is a condition that affects people who have asthma or cystic fibrosis. It is caused by an allergic reaction to Aspergillus fungus in the lungs. Prednisolone is a corticosteroid that can be used to treat inflammation in the lungs associated with ABPA, but it does not cause ABPA. + + + Therefore, while prednisolone may be related to ABPA in terms" +19750187,Prednisolone related to lymphoma,220,OBJECTIVE: To assess the treatment effect of sodium hyaluronate (HA) on experimental temporomandibular joint (TMJ) osteoarthritis of rabbits in comparison with prednisolone (PS).,False,Is the triple 'Prednisolone related to lymphoma' supported by the sentence: 'OBJECTIVE: To assess the treatment effect of sodium hyaluronate (HA) on experimental temporomandibular joint (TMJ) osteoarthritis of rabbits in comparison with prednisolone (PS).'?,"No, the statement does not provide indirect support for the phrase ""Prednisolone related to lymphoma."" The objective is about an experimental study comparing sodium hyaluronate (HA) treatment effect on temporomandibular joint (TMJ) osteoarthritis in rabbits versus prednisolone (PS). The statement does not make any connection between prednisolone and lymphoma; hence it does not support the given phrase. + + Prednisolone is a synthetic glucocorticoid used in various clinical settings for its potent anti-inflammatory effects; however, it has been associated with increased risks for certain malignancies such as lymphoma in some studies. Nonetheless, more evidence is required before making any direct connection between prednisolone use and lymphoma development. In order for there to be indirect support for such a claim using the provided statement as evidence, there would need to be some mention linking prednisolone use in rabbits (or animals in general) to lymphoma; however, such information is absent from the statement provided." +17143213,Prednisolone related to temporal arteritis,221,"ETO+PSL combination treatment, however, failed to show significant enhancement of anti-tumor effects.",False,"Is the triple 'Prednisolone related to temporal arteritis' supported by the sentence: 'ETO+PSL combination treatment, however, failed to show significant enhancement of anti-tumor effects.'?","No, the statement ""ETO+PSL combination treatment, however, failed to show significant enhancement of anti-tumor effects"" does not provide indirect support for the phrase ""Prednisolone related to temporal arteritis."" + + Prednisolone (PSL) is a type of corticosteroid drug often used in treating various conditions such as temporal arteritis due to its potent anti-inflammatory properties. ETO likely refers to Etoposide, another drug used in cancer treatment. The statement provided discusses an experimental combination therapy (ETO+PSL) for enhancing anti-tumor effects in cancer treatment without significant success. + + The connection between prednisolone and temporal arteritis is not addressed or implied in this statement because it focuses on anti-tumor effects rather than inflammatory responses in blood vessels (the primary issue in temporal arteritis). Therefore, it does not offer any support for linking prednisolone to temporal arteritis based on this information alone." +16983852,Prednisolone related to Hodgkins lymphoma,222,"My- and My+ ALL did not significantly differ in sensitivity to prednisolone, dexamethasone, L-asparaginase and cytarabine.",False,"Is the triple 'Prednisolone related to Hodgkins lymphoma' supported by the sentence: 'My- and My+ ALL did not significantly differ in sensitivity to prednisolone, dexamethasone, L-asparaginase and cytarabine.'?","No, the statement does not provide indirect support for the phrase ""Prednisolone related to Hodgkins lymphoma."" The statement discusses the sensitivity of My- and My+ acute lymphoblastic leukemia (ALL) to several drugs including prednisolone, but it does not mention Hodgkin lymphoma at all. Therefore, there is no connection that can be inferred between prednisolone and Hodgkin lymphoma from this statement. + + It is important to note that Hodgkin lymphoma is a distinct type of cancer from acute lymphoblastic leukemia (ALL), which is mentioned in the statement. Therefore, even if the statement had mentioned an association between prednisolone and ALL, it would not necessarily imply an association between prednisolone and Hodgkin lymphoma. + + In order for there to be indirect support for the phrase ""Prednisolone related to Hodgkins lymphoma,"" there would need to be some mention or implication in the statement that prednisolone has an effect on Hodgkin lymphoma specifically" +16960031,Prednisolone related to psoriatic arthritis,223,"The dose of prednisolone was increased considering he was exacerbated of SLE, however, the convulsion as CNS lupus occurred to him.",False,"Is the triple 'Prednisolone related to psoriatic arthritis' supported by the sentence: 'The dose of prednisolone was increased considering he was exacerbated of SLE, however, the convulsion as CNS lupus occurred to him.'?","No, the statement does not provide indirect support for the phrase ""Prednisolone related to psoriatic arthritis"". The statement discusses the increase in prednisolone dosage due to an exacerbation of Systemic Lupus Erythematosus (SLE) in a patient who subsequently experienced convulsions due to Central Nervous System lupus (CNS lupus). Psoriatic arthritis is a different condition from SLE and is not mentioned in the statement. Therefore, there is no connection established between prednisolone and psoriatic arthritis in this context." +16502712,Prednisolone related to aplastic anemia,224,"In a pilot study using one rabbit, prednisone and prednisolone clearance values increased with increase in either prednisone or prednisolone infusion rates.",False,"Is the triple 'Prednisolone related to aplastic anemia' supported by the sentence: 'In a pilot study using one rabbit, prednisone and prednisolone clearance values increased with increase in either prednisone or prednisolone infusion rates.'?","No, the statement does not provide direct or indirect support for the phrase ""Prednisolone related to aplastic anemia"". The pilot study mentioned only discusses how prednisone and prednisolone clearance values change with increased infusion rates in one rabbit. There is no mention of aplastic anemia in the statement; therefore it does not offer any evidence linking prednisolone to aplastic anemia. + + To provide indirect support for such a claim, there would need to be some connection between prednisolone use and decreased clearance values, which could then be associated with an increased risk for developing aplastic anemia due to higher drug exposure over time. However, none of these connections can be inferred from the provided statement. + + Aplastic anemia is an uncommon but serious condition where the body stops producing enough new blood cells. Prednisolone is a corticosteroid that can suppress inflammation and immune response; however, its long-term use has been linked to various side effects such as osteoporosis, weight gain, diabetes, cataracts, glaucoma, increased risk of infections, and ad" +16371065,Prednisolone related to celiac disease,225,"Budesonide is equal to less effective than prednisolone or prednisone therapy in the treatment of active Crohn's disease, but is associated with fewer glucocorticoids adverse reactions.",False,"Is the triple 'Prednisolone related to celiac disease' supported by the sentence: 'Budesonide is equal to less effective than prednisolone or prednisone therapy in the treatment of active Crohn's disease, but is associated with fewer glucocorticoids adverse reactions.'?","No, the statement does not provide direct or indirect support for the phrase ""Prednisolone related to celiac disease."" The statement discusses the efficacy and side effects of Budesonide, Prednisolone, and Prednisone in treating Crohn's disease, but it does not mention or imply any connection between Prednisolone and celiac disease. Celiac disease is an autoimmune disorder triggered by gluten in genetically predisposed individuals, while Prednisolone is a corticosteroid medication used for various inflammatory conditions. Therefore, without further evidence linking Prednisolone specifically to celiac disease, it is not reasonable to make such a connection based on the given statement alone." +16192798,Prednisolone related to dermatomyositis,226,Diclofenac and prednisolone inhibit endotoxin-induced uveitis in rabbits.,False,Is the triple 'Prednisolone related to dermatomyositis' supported by the sentence: 'Diclofenac and prednisolone inhibit endotoxin-induced uveitis in rabbits.'?,"No, the statement ""Diclofenac and prednisolone inhibit endotoxin-induced uveitis in rabbits"" does not provide indirect support for the phrase ""Prednisolone related to dermatomyositis"". + + The statement discusses the effects of diclofenac and prednisolone on endotoxin-induced uveitis in rabbits. While it does indicate that prednisolone has an effect in this specific context, it does not provide any information about its relationship to dermatomyositis. Dermatomyositis is a specific medical condition characterized by inflammation and damage to muscle tissue and the skin. The statement does not provide any evidence or imply any connection between prednisolone and this condition. Therefore, it cannot be used as indirect support for the phrase in question." +16169223,Prednisolone related to mucocutaneous lymph node syndrome,227,"Although prednisolone and GH reverse hypoglycemia by different mechanisms, with only prednisolone suppressing tumor IGF-II secretion, both increase the formation of ternary IGF-IGFBP-3 complexes.",False,"Is the triple 'Prednisolone related to mucocutaneous lymph node syndrome' supported by the sentence: 'Although prednisolone and GH reverse hypoglycemia by different mechanisms, with only prednisolone suppressing tumor IGF-II secretion, both increase the formation of ternary IGF-IGFBP-3 complexes.'?","No, the statement does not provide indirect support for the phrase ""Prednisolone related to mucocutaneous lymph node syndrome"". The statement discusses the effects of prednisolone on hypoglycemia and IGF-IGFBP-3 complexes but does not mention or imply any connection to mucocutaneous lymph node syndrome. Mucocutaneous lymph node syndrome is an immune system disorder characterized by fever, swollen lymph nodes, skin rashes, and other symptoms, which has not been linked to prednisolone in the provided statement. Therefore, it is inappropriate to make such a connection based on this information alone." +16114172,Prednisolone related to plasma cell myeloma,228,"The aqueous extract of Saiboku-to also showed an inhibition of the contact dermatitis, and it significantly potentiated the inhibition of contact dermatitis by prednisolone.",False,"Is the triple 'Prednisolone related to plasma cell myeloma' supported by the sentence: 'The aqueous extract of Saiboku-to also showed an inhibition of the contact dermatitis, and it significantly potentiated the inhibition of contact dermatitis by prednisolone.'?","No, the statement does not provide direct or indirect support for the phrase ""Prednisolone related to plasma cell myeloma."" The statement discusses an inhibitory effect of prednisolone on contact dermatitis when combined with an aqueous extract of Saiboku-to. There is no mention or implication of any connection between prednisolone and plasma cell myeloma in this statement. + + To further clarify, let me explain how I arrived at my decision: + + 1) The statement focuses on the inhibitory effect of prednisolone on contact dermatitis when combined with an herbal extract called Saiboku-to. + + 2) Plasma cell myeloma is a type of cancer affecting plasma cells in bone marrow, which is unrelated to contact dermatitis or skin inflammation addressed in the statement. + + 3) The provided statement does not mention any studies, experiments, or evidence linking prednisolone to plasma cell myeloma; therefore, it does not provide indirect support either. + + 4) Prednisolone is a synthetic glucocorticoid often used in treating various inflammatory diseases due" +14564343,Prednisolone related to acute lymphoblastic leukemia,229,Only hydrocortisone and prednisolone suppressed LPS pneumonia.,False,Is the triple 'Prednisolone related to acute lymphoblastic leukemia' supported by the sentence: 'Only hydrocortisone and prednisolone suppressed LPS pneumonia.'?,"No, the statement does not provide indirect support for the phrase ""Prednisolone related to acute lymphoblastic leukemia."" The statement ""Only hydrocortisone and prednisolone suppressed LPS pneumonia"" addresses the immunosuppressive effects of these corticosteroids in treating LPS pneumonia but does not imply any connection between prednisolone and acute lymphoblastic leukemia (ALL). Acute lymphoblastic leukemia is a type of cancer affecting blood cells, while prednisolone is an immunosuppressive drug used in various clinical settings unrelated to ALL. Therefore, further evidence would be required to establish any link between prednisolone and ALL." +13988965,Prednisolone related to osteoarthritis,230,"Prednisolone significantly inhibited the measurable sensitivity of IDT, while oclacitinib did not.",False,"Is the triple 'Prednisolone related to osteoarthritis' supported by the sentence: 'Prednisolone significantly inhibited the measurable sensitivity of IDT, while oclacitinib did not.'?","No, the statement does not provide direct or indirect support for the phrase ""Prednisolone related to osteoarthritis"". The given statement compares the effects of Prednisolone and oclacitinib on IDT sensitivity but does not mention osteoarthritis. Therefore, we cannot infer any relationship between Prednisolone and osteoarthritis from this information alone." +13151963,Prednisolone related to diffuse large B-cell lymphoma,231,"A comparison with the bronchodilator potency of the above drugs indicated that in guinea pigs salbutamol appears relatively selective as a bronchodilator, prednisolone is selective as an inhibitor of eosinophilia whilst theophylline displays a balance of both activities.",False,"Is the triple 'Prednisolone related to diffuse large B-cell lymphoma' supported by the sentence: 'A comparison with the bronchodilator potency of the above drugs indicated that in guinea pigs salbutamol appears relatively selective as a bronchodilator, prednisolone is selective as an inhibitor of eosinophilia whilst theophylline displays a balance of both activities.'?","No, the statement does not provide indirect support for the phrase ""Prednisolone related to diffuse large B-cell lymphoma."" The statement discusses the effects of prednisolone as an inhibitor of eosinophilia in guinea pigs when compared to other drugs like salbutamol and theophylline. There is no mention or implication of any relationship between prednisolone and diffuse large B-cell lymphoma in humans in this statement." +13151962,Prednisolone related to follicular lymphoma,232,Reduction of maintenance doses of prednisolone in bronchial asthma by the concurrent use of hydroxyzine.,False,Is the triple 'Prednisolone related to follicular lymphoma' supported by the sentence: 'Reduction of maintenance doses of prednisolone in bronchial asthma by the concurrent use of hydroxyzine.'?,"No, the statement does not provide indirect support for the phrase ""Prednisolone related to follicular lymphoma."" The statement discusses reducing maintenance doses of prednisolone in bronchial asthma through concurrent use of hydroxyzine but does not mention or imply any connection between prednisolone and follicular lymphoma. The two subjects—asthma and follicular lymphoma—are distinct conditions that require separate considerations in medical literature. To establish support for the phrase ""Prednisolone related to follicular lymphoma,"" evidence should explicitly demonstrate some form of correlation or causation between prednisolone usage and follicular lymphoma incidence or progression." +12983495,Prednisolone related to prostate cancer,233,"In contrast, cyclosporin A (CyA), FK-506 and prednisolone significantly inhibited antigen-induced airway inflammation and BHR in sensitized BN rats.",False,"Is the triple 'Prednisolone related to prostate cancer' supported by the sentence: 'In contrast, cyclosporin A (CyA), FK-506 and prednisolone significantly inhibited antigen-induced airway inflammation and BHR in sensitized BN rats.'?","No, the statement does not provide indirect support for the phrase ""Prednisolone related to prostate cancer"". The provided quote discusses how prednisolone inhibits antigen-induced airway inflammation and bronchial hyperresponsiveness (BHR) in sensitized Brown Norway (BN) rats, which is related to allergic reactions in the respiratory system rather than prostate cancer. + + To establish an indirect link between prednisolone and prostate cancer based on this information, there would need to be some connection between antigen-induced airway inflammation/BHR and prostate cancer; however, no such link has been suggested in the statement provided. Therefore, it is inappropriate to infer any relationship between prednisolone and prostate cancer based solely on this information." +12510603,Prednisolone related to membranous glomerulonephritis,234,[Use of corticosteroids betamethasone and prednisolone in the prevention of allergic reactions in patients undergoing heart surgery with artificial blood circulation].,False,Is the triple 'Prednisolone related to membranous glomerulonephritis' supported by the sentence: '[Use of corticosteroids betamethasone and prednisolone in the prevention of allergic reactions in patients undergoing heart surgery with artificial blood circulation].'?,"No, the statement does not provide direct or indirect support for the phrase ""Prednisolone related to membranous glomerulonephritis."" The statement discusses the use of corticosteroids betamethasone and prednisolone in preventing allergic reactions during heart surgery, which is unrelated to membranous glomerulonephritis. Membranous glomerulonephritis is a kidney disorder characterized by inflammation in the glomeruli (tiny filters in the kidneys), which can be caused by various factors such as infections, autoimmune diseases, or medications, but it is not explicitly associated with prednisolone in this context." +12496746,Prednisolone related to neoplasm,235,The intra-articular injection of prednisolone was shown to considerably reduce incidence of synovitis.,False,Is the triple 'Prednisolone related to neoplasm' supported by the sentence: 'The intra-articular injection of prednisolone was shown to considerably reduce incidence of synovitis.'?,"No, the statement ""The intra-articular injection of prednisolone was shown to considerably reduce incidence of synovitis"" does not provide indirect support for the phrase ""Prednisolone related to neoplasm."" Synovitis is an inflammation of the synovial membrane that lines joints, while neoplasm refers to abnormal growths that can be benign or malignant (cancerous). Although prednisolone has anti-inflammatory properties that can help manage synovitis, there is no direct link established between prednisolone use and neoplasm development in this statement. However, it is important to note that corticosteroids like prednisolone have been associated with certain increased risks for specific types of cancers in some studies; thus, further investigation would be required for a definitive conclusion on any relationship between prednisolone use and neoplasm risk." +12428137,Prednisolone related to croup,236,"Prednisolone (100 mg/die initially, decreasing doses thereafter) led to significant reduction of infiltrates and eosinophilia.",True,"Is the triple 'Prednisolone related to croup' supported by the sentence: 'Prednisolone (100 mg/die initially, decreasing doses thereafter) led to significant reduction of infiltrates and eosinophilia.'?","Yes, there is indirect support for the statement ""Prednisolone related to croup"" from the given evidence. The statement indicates that prednisolone treatment led to a significant reduction in infiltrates and eosinophilia. Croup is a viral infection that often leads to inflammation in the upper airways, which can result in infiltrates and eosinophilia (accumulation of eosinophils in tissues). By demonstrating that prednisolone reduces infiltrates and eosinophilia, it suggests that prednisolone can help alleviate symptoms associated with croup by minimizing inflammation in the upper airways. However, it is important to note that direct evidence specifically linking prednisolone and croup would provide stronger support for the claim." +12061894,Prednisolone related to West syndrome,237,The tumour was significantly reduced by prednisolone.,False,Is the triple 'Prednisolone related to West syndrome' supported by the sentence: 'The tumour was significantly reduced by prednisolone.'?,"No, the statement ""The tumour was significantly reduced by prednisolone"" does not provide direct or indirect support for the phrase ""Prednisolone related to West syndrome"". + + West syndrome is a specific neurological disorder characterized by infantile spasms, developmental regression, and hypsarrhythmia on EEG. It is often associated with underlying brain abnormalities such as tuberous sclerosis complex, cortical dysplasia, or hypoxic-ischemic encephalopathy. The statement only indicates that prednisolone has an effect on reducing tumour size, which does not necessarily imply any connection with West syndrome. + + To establish a relationship between prednisolone and West syndrome, further evidence would be required demonstrating that prednisolone has an effect on the symptoms or underlying pathophysiology specific to West syndrome. This could include studies showing that prednisolone reduces infantile spasms or improves developmental outcomes in patients with West syndrome. + + Therefore, while prednisolone may have therapeutic value in certain contexts, such as reducing tumour size in brain cancers, it" +11663099,Prednisolone related to Crohn disease,238,"Prednisolone prevented the development of colitis, but had no effect on already-developed colitis.",True,"Is the triple 'Prednisolone related to Crohn disease' supported by the sentence: 'Prednisolone prevented the development of colitis, but had no effect on already-developed colitis.'?","Yes, indirectly it does support that prednisolone is related to Crohn disease. The statement suggests that prednisolone has an effect on colitis prevention, which is a symptom often associated with Crohn disease, a type of inflammatory bowel disease (IBD). Therefore, it implies that prednisolone has some connection or relation to Crohn disease by influencing its symptoms. However, it is essential to note that correlation does not imply causation; more research would be needed to confirm this relationship conclusively." +11638013,Prednisolone related to eosinophilic granulomatosis with polyangiitis,239,Alveolar NO concentration was increased in patients with refractory asthma (7.1 ppb) compared with mild-to-moderate asthma (3.4 ppb) and normal controls (3.4 ppb) and reduced by treatment with prednisolone.,True,Is the triple 'Prednisolone related to eosinophilic granulomatosis with polyangiitis' supported by the sentence: 'Alveolar NO concentration was increased in patients with refractory asthma (7.1 ppb) compared with mild-to-moderate asthma (3.4 ppb) and normal controls (3.4 ppb) and reduced by treatment with prednisolone.'?,"Yes, indirectly it does support that statement. The given statement mentions that alveolar NO concentration is increased in patients with refractory asthma compared to mild-to-moderate asthma and normal controls, and that treatment with prednisolone reduces it. This implies that prednisolone may have an effect on eosinophilic granulomatosis with polyangiitis (EGPA) since EGPA is often associated with asthma symptoms. However, it does not provide direct evidence for prednisolone being related specifically to EGPA but rather suggests its potential effect on inflammation in general which is often observed in EGPA as well as other conditions including asthma. + + The connection between prednisolone and EGPA can be further supported by existing medical literature where prednisolone is commonly used as part of standard therapy for EGPA due to its anti-inflammatory properties. Nonetheless, more specific studies would need to be conducted to definitively establish such a link." +11213963,Prednisolone related to leprosy,240,"Prednisolone treatment of sensory impairment of the ulnar and posterior tibial nerves detectable with the monofilament test, but not with the ballpen test, did not improve the long-term outcome in terms of recovery of touch sensibility, not did it reduce the risk of leprosy reactions or nerve function impairment beyond the initial 4-month treatment phase.",False,"Is the triple 'Prednisolone related to leprosy' supported by the sentence: 'Prednisolone treatment of sensory impairment of the ulnar and posterior tibial nerves detectable with the monofilament test, but not with the ballpen test, did not improve the long-term outcome in terms of recovery of touch sensibility, not did it reduce the risk of leprosy reactions or nerve function impairment beyond the initial 4-month treatment phase.'?","No, the statement does not provide indirect support for the phrase ""Prednisolone related to leprosy."" The statement discusses the effects of Prednisolone treatment on sensory impairment and leprosy reactions or nerve function impairment, but it does not establish a direct relationship between Prednisolone and leprosy itself. Therefore, based on this information alone, one cannot infer that Prednisolone is related to leprosy in any way." +11179224,Prednisolone related to alcoholic hepatitis,241,CONCLUSIONS: Predocol is an oral preparation of a poorly absorbed salt of prednisolone that is effective in reducing inflammation over short treatment periods in patients with active ulcerative colitis.,False,Is the triple 'Prednisolone related to alcoholic hepatitis' supported by the sentence: 'CONCLUSIONS: Predocol is an oral preparation of a poorly absorbed salt of prednisolone that is effective in reducing inflammation over short treatment periods in patients with active ulcerative colitis.'?,"No, the statement does not provide indirect support for the phrase ""Prednisolone related to alcoholic hepatitis."" The conclusion is about Prednisolone being effective in treating ulcerative colitis, which is an inflammatory bowel disease. There is no mention or implication of alcoholic hepatitis in this statement. Alcoholic hepatitis is a liver condition caused by excessive consumption of alcohol over time. Prednisolone may be used in treating various inflammatory conditions but is not specifically related to alcoholic hepatitis based on this information alone." +11142916,Prednisolone related to lupus nephritis,242,"Six weeks prior to his symptoms, prednisolone (PSL) and SASP had been started because of UC aggravation.",False,"Is the triple 'Prednisolone related to lupus nephritis' supported by the sentence: 'Six weeks prior to his symptoms, prednisolone (PSL) and SASP had been started because of UC aggravation.'?","No, the statement ""Six weeks prior to his symptoms, prednisolone (PSL) and SASP had been started because of UC aggravation"" does not provide direct or indirect support for the phrase ""Prednisolone related to lupus nephritis"". The statement only indicates that prednisolone was administered due to ulcerative colitis (UC) aggravation, not lupus nephritis. The connection between prednisolone use and lupus nephritis has not been established in this statement." +11037266,Prednisolone related to granulomatosis with polyangiitis,243,"When comparing organ specific, age-adjusted expected versus observed incidences after natural death of animals an increased tumor risk was found in organ systems of all treatment modalities but prednisolone.",False,"Is the triple 'Prednisolone related to granulomatosis with polyangiitis' supported by the sentence: 'When comparing organ specific, age-adjusted expected versus observed incidences after natural death of animals an increased tumor risk was found in organ systems of all treatment modalities but prednisolone.'?","No, the statement does not provide indirect support for the phrase ""Prednisolone related to granulomatosis with polyangiitis"". The provided statement discusses an increased tumor risk in organ systems associated with various treatment modalities compared to natural death in animals, one of which is prednisolone. However, it does not establish any connection between prednisolone and granulomatosis with polyangiitis (GPA). + + Granulomatosis with polyangiitis is an autoimmune disease characterized by inflammation in blood vessels, often affecting the respiratory system and kidneys. Prednisolone is a corticosteroid medication commonly used in treating GPA due to its potent anti-inflammatory properties. However, the statement only addresses prednisolone as a risk factor for tumor development in animals, which does not necessarily imply any relationship between prednisolone and GPA in humans. + + In summary, while prednisolone may have various clinical applications, including GPA treatment, the statement does not provide any indirect support for prednisolone being related to GPA due to its focus on tumor risk in animals rather than GPA inc" +11013570,Prednisolone related to leukemia,244,"R-CHOP chemotherapy composed of rituximab, cyclophosphamide, adriamycin, vincristine, and prednisolone which might increase the risk of Pneumocystis pneumonia in patients with non-Hodgkin lymphoma.",False,"Is the triple 'Prednisolone related to leukemia' supported by the sentence: 'R-CHOP chemotherapy composed of rituximab, cyclophosphamide, adriamycin, vincristine, and prednisolone which might increase the risk of Pneumocystis pneumonia in patients with non-Hodgkin lymphoma.'?","No, the statement does not provide direct or indirect support for the phrase ""Prednisolone related to leukemia."" The statement discusses R-CHOP chemotherapy as a treatment for non-Hodgkin lymphoma, which includes prednisolone as one of its components. It then mentions that such therapy might increase the risk of Pneumocystis pneumonia in patients. Although prednisolone has been linked to various side effects due to its immunosuppressive nature, there is no connection established in this statement between prednisolone and leukemia. Leukemia is a type of cancer that originates in blood-forming tissues, whereas prednisolone is primarily used as an anti-inflammatory and immunosuppressive drug in cancer treatments but does not cause leukemia." +10949449,Prednisolone related to polymyalgia rheumatica,245,"Cortisol deficiency is common in late stage HIV disease, but symptoms of fatigue and postural hypotension, as well as biochemical findings, are poor predictors of cortisol deficiency.",False,"Is the triple 'Prednisolone related to polymyalgia rheumatica' supported by the sentence: 'Cortisol deficiency is common in late stage HIV disease, but symptoms of fatigue and postural hypotension, as well as biochemical findings, are poor predictors of cortisol deficiency.'?","No, the statement does not provide indirect support for the phrase ""Prednisolone related to polymyalgia rheumatica."" The connection between cortisol deficiency in late-stage HIV disease and polymyalgia rheumatica is not evident in the provided statement. The statement focuses on cortisol deficiency in late-stage HIV disease and its poor correlation with symptoms and biochemical findings. Prednisolone is commonly used as an anti-inflammatory agent in treating polymyalgia rheumatica, an autoimmune disorder characterized by muscle pain and stiffness in the shoulders and hips. The statement does not mention Prednisolone nor polymyalgia rheumatica; thus, it does not offer indirect support for their connection." +10748640,Prednisolone related to infertility disorder,246,[Plasma cortisol and 17-ketosteroids in urine in relation to cardiac arrest].,False,Is the triple 'Prednisolone related to infertility disorder' supported by the sentence: '[Plasma cortisol and 17-ketosteroids in urine in relation to cardiac arrest].'?,"No, the statement ""Prednisolone related to infertility disorder"" does not receive indirect support from the provided statement: ""[Plasma cortisol and 17-ketosteroids in urine in relation to cardiac arrest]."" + + The provided statement discusses Plasma cortisol and 17-ketosteroids in urine in relation to cardiac arrest. Prednisolone is a synthetic glucocorticoid which is structurally similar to cortisol (a type of glucocorticoid) but it is not mentioned in the statement. Also there is no mention of infertility disorder in the statement. Therefore we can not infer any relation between Prednisolone and infertility disorder from it. + + It is important to note that infertility is a complex disorder that can be caused by various factors including genetic, environmental, hormonal imbalances etc. Prednisolone is primarily used as an anti-inflammatory drug but it can have side effects on various organ systems including reproductive system which can lead to infertility but that would require further investigation and direct evidence." +10744705,"Prednisolone related to dermatitis, atopic",247,"Independence of theta and TL surface antigens and killing by thymidine, cortisol, phytohemagglutinin, and cyclic AMP in a murine lymphoma.",False,"Is the triple 'Prednisolone related to dermatitis, atopic' supported by the sentence: 'Independence of theta and TL surface antigens and killing by thymidine, cortisol, phytohemagglutinin, and cyclic AMP in a murine lymphoma.'?","No, the statement ""Independence of theta and TL surface antigens and killing by thymidine, cortisol, phytohemagglutinin, and cyclic AMP in a murine lymphoma"" does not provide indirect support for the phrase ""Prednisolone related to dermatitis, atopic"". + + The statement discusses the independence of certain surface antigens (theta and TL) and the killing effect of various substances (thymidine, cortisol, phytohemagglutinin, and cyclic AMP) on murine lymphoma cells. Prednisolone is not mentioned in this statement, nor is there any connection made to dermatitis, atopic or any other skin conditions. Therefore, it does not offer any form of support for the given phrase." +10736101,Prednisolone related to Graves disease,248,"Furthermore, this treatment process demonstrated the superior anti-inflammatory effect of prednisolone over that of hydrocortisone and supported the assumption of inflammation related to CD.",True,"Is the triple 'Prednisolone related to Graves disease' supported by the sentence: 'Furthermore, this treatment process demonstrated the superior anti-inflammatory effect of prednisolone over that of hydrocortisone and supported the assumption of inflammation related to CD.'?","Yes, indirectly it does lend some support. The statement suggests that prednisolone has a superior anti-inflammatory effect compared to hydrocortisone and supports the assumption that inflammation is related to CD (presumably an abbreviation for a condition or disease). Graves disease is indeed associated with inflammation, so if we assume that CD refers to Graves disease in this context, then the statement does provide indirect support for the connection between prednisolone and Graves disease. However, it's important to note that this is an indirect inference and does not provide direct evidence of a causal relationship between prednisolone and Graves disease. Further investigation would be required to establish such a link conclusively." +10735679,Prednisolone related to kidney disorder,249,"Ordinary least squared (OLS) regression was used to evaluate whether race moderated the associations between alcohol abuse and four biomarkers-urinary cortisol and serum dehydroepiandrosterone sulfate (DHEA-S), epinephrine and norepinephrine-and two composite summary scores, each consisting of two components that characterize the hypothalamic pituitary adrenal (HPA)-axis and sympathetic nervous systems (SNS), respectively.",False,"Is the triple 'Prednisolone related to kidney disorder' supported by the sentence: 'Ordinary least squared (OLS) regression was used to evaluate whether race moderated the associations between alcohol abuse and four biomarkers-urinary cortisol and serum dehydroepiandrosterone sulfate (DHEA-S), epinephrine and norepinephrine-and two composite summary scores, each consisting of two components that characterize the hypothalamic pituitary adrenal (HPA)-axis and sympathetic nervous systems (SNS), respectively.'?","No, the statement does not provide direct or indirect support for the phrase ""Prednisolone related to kidney disorder."" The provided statement discusses an OLS regression analysis that evaluated whether race moderated the associations between alcohol abuse and four biomarkers related to the HPA-axis and SNS systems. Prednisolone is not mentioned in the statement, nor is there any connection made between alcohol abuse, kidney disorder, or any related biological systems." +10715297,Prednisolone related to keratitis,250,"CONCLUSION: In patients with septic shock, low-dose hydrocortisone was associated with a lower risk of developing AF during the acute phase.",False,"Is the triple 'Prednisolone related to keratitis' supported by the sentence: 'CONCLUSION: In patients with septic shock, low-dose hydrocortisone was associated with a lower risk of developing AF during the acute phase.'?","No, the statement ""Prednisolone related to keratitis"" does not receive indirect support from the conclusion provided in the study about septic shock patients and low-dose hydrocortisone use. The conclusion in question focuses on the association between low-dose hydrocortisone and atrial fibrillation (AF) risk in septic shock patients during the acute phase. + + The two statements involve different medical conditions (septic shock vs keratitis), drug treatments (low-dose hydrocortisone vs prednisolone), and outcomes (AF risk vs keratitis incidence). As such, there is no clear connection between them that would lend indirect support to the claim about prednisolone being related to keratitis based on the provided conclusion about low-dose hydrocortisone in septic shock patients. + + To establish an indirect link between prednisolone use and keratitis risk, one would need evidence from studies involving prednisolone specifically and its association with keratitis incidence. Therefore, further investigation is necessary before making any conclusions about prednisolone being related to keratitis based on existing evidence related to other cortic" +10703266,Prednisolone related to ulcerative colitis,251,"The incidence of psychological symptoms as somatization, obsessive-compulsive symptoms, depression, anxiety, phobia, and nonspecific symptoms is statistically increased in pregnant women with elevated morning cortisol, but in women with elevated afternoon cortisol also occurring aggressiveness and paranoia.",False,"Is the triple 'Prednisolone related to ulcerative colitis' supported by the sentence: 'The incidence of psychological symptoms as somatization, obsessive-compulsive symptoms, depression, anxiety, phobia, and nonspecific symptoms is statistically increased in pregnant women with elevated morning cortisol, but in women with elevated afternoon cortisol also occurring aggressiveness and paranoia.'?","No, the statement does not provide direct or indirect support for the phrase ""Prednisolone related to ulcerative colitis."" + + The statement discusses the psychological symptoms associated with elevated cortisol levels in pregnant women, specifically differentiating between morning and afternoon cortisol levels. Prednisolone is a synthetic glucocorticoid often used in treating various conditions such as ulcerative colitis, asthma, rheumatoid arthritis, and other autoimmune diseases due to its anti-inflammatory properties. + + Although cortisol is another glucocorticoid like Prednisolone, no direct connection is established between Prednisolone use for ulcerative colitis and cortisol levels in pregnant women in this statement. Therefore, it does not provide any support for the phrase ""Prednisolone related to ulcerative colitis.""" +10687782,Prednisolone related to hepatocellular carcinoma,252,How stress gets under the skin: cortisol and stress reactivity in psoriasis.,False,Is the triple 'Prednisolone related to hepatocellular carcinoma' supported by the sentence: 'How stress gets under the skin: cortisol and stress reactivity in psoriasis.'?,"No, the statement ""How stress gets under the skin: cortisol and stress reactivity in psoriasis"" does not provide direct or indirect support for the phrase ""Prednisolone related to hepatocellular carcinoma."" + + + + Prednisolone is a synthetic glucocorticoid hormone used primarily for its anti-inflammatory effects, while hepatocellular carcinoma is a type of liver cancer. Although both prednisolone and stress (which can increase cortisol levels) have been linked to liver damage in some studies, there is no direct connection between prednisolone use and hepatocellular carcinoma specifically in the provided statement. + + + + The statement focuses on cortisol (a stress hormone) and stress reactivity in psoriasis patients, rather than prednisolone use or hepatocellular carcinoma. Cortisol has complex effects on inflammation and immune response modulation, but it is not equivalent to prednisolone in terms of pharmacological action or cancer risk. + + + + In conclusion, while both prednisolone" +10623724,Prednisolone related to hemolytic anemia,253,Absorption of hydrocortisone from the skin reservoir in atopic dermatitis.,False,Is the triple 'Prednisolone related to hemolytic anemia' supported by the sentence: 'Absorption of hydrocortisone from the skin reservoir in atopic dermatitis.'?,"No, the statement ""Absorption of hydrocortisone from the skin reservoir in atopic dermatitis"" does not provide indirect support for the phrase ""Prednisolone related to hemolytic anemia."" + + These two statements pertain to different corticosteroids (hydrocortisone vs prednisolone) and different medical conditions (atopic dermatitis vs hemolytic anemia). While both hydrocortisone and prednisolone can cause side effects such as hemolytic anemia due to their immunosuppressive properties, one statement does not imply or support the other in any way. + + The absorption of hydrocortisone from the skin reservoir in atopic dermatitis is related to the drug delivery method and its efficacy in treating atopic dermatitis, not its potential side effects like hemolytic anemia. Hemolytic anemia as a side effect would depend on factors such as dosage, duration of treatment, patient characteristics, and pharmacogenetics rather than the route of administration alone. + + Therefore, further evidence would be required to" +10576837,Prednisolone related to juvenile idiopathic arthritis,254,OBJECTIVE: To assess dexamethasone (DEX) and hydrocortisone (HC) use in premature infants over time and the association of steroid use with the incidence of bronchopulmonary dysplasia (BPD) at 36 weeks' postmenstrual age.,False,Is the triple 'Prednisolone related to juvenile idiopathic arthritis' supported by the sentence: 'OBJECTIVE: To assess dexamethasone (DEX) and hydrocortisone (HC) use in premature infants over time and the association of steroid use with the incidence of bronchopulmonary dysplasia (BPD) at 36 weeks' postmenstrual age.'?,"No, the statement does not provide indirect support for the phrase ""Prednisolone related to juvenile idiopathic arthritis."" The objective in the statement is focused on assessing dexamethasone (DEX) and hydrocortisone (HC) use in premature infants over time and their association with bronchopulmonary dysplasia (BPD) at 36 weeks postmenstrual age. Prednisolone is not mentioned in the statement, nor is there any connection made between steroid use in premature infants and juvenile idiopathic arthritis." +10565620,Prednisolone related to nephrotic syndrome,255,Increased ratio of mRNA expression of the genes CYP17 and CYP11B1 indicates autonomous cortisol production in adrenocortical tumors.,False,Is the triple 'Prednisolone related to nephrotic syndrome' supported by the sentence: 'Increased ratio of mRNA expression of the genes CYP17 and CYP11B1 indicates autonomous cortisol production in adrenocortical tumors.'?,"No, the statement does not provide direct or indirect support for the phrase ""Prednisolone related to nephrotic syndrome."" + + Prednisolone is a synthetic glucocorticoid often used in treating nephrotic syndrome, but it is not explicitly mentioned in the given statement about CYP17 and CYP11B1 mRNA expression ratios in adrenocortical tumors. The statement refers specifically to cortisol production in adrenocortical tumors, not Prednisolone use or nephrotic syndrome. + + The connection between Prednisolone and nephrotic syndrome is well-established in medical literature; however, without further evidence linking cortisol production in adrenocortical tumors (as indicated by CYP17 and CYP11B1 mRNA expression ratios) to Prednisolone use in nephrotic syndrome patients, it would be inappropriate to infer any relationship between them based on the provided statement alone." +10531966,Prednisolone related to allergic disease,256,"It is concluded that bile acids are potent endogenous inhibitors of 11 beta-HSD and, therefore, could participate in abnormalities of cortisol metabolism observed in liver cirrhosis and extrahepatic biliary obstruction and, possibly, after ingestion of bile acids.",False,"Is the triple 'Prednisolone related to allergic disease' supported by the sentence: 'It is concluded that bile acids are potent endogenous inhibitors of 11 beta-HSD and, therefore, could participate in abnormalities of cortisol metabolism observed in liver cirrhosis and extrahepatic biliary obstruction and, possibly, after ingestion of bile acids.'?","No, the statement ""It is concluded that bile acids are potent endogenous inhibitors of 11 beta-HSD and, therefore, could participate in abnormalities of cortisol metabolism observed in liver cirrhosis and extrahepatic biliary obstruction and, possibly, after ingestion of bile acids."" does not provide indirect support for the phrase ""Prednisolone related to allergic disease."" + + The statement discusses the role of bile acids as inhibitors of 11 beta-HSD (11-beta-hydroxysteroid dehydrogenase), an enzyme involved in cortisol metabolism. The inhibition of 11 beta-HSD can lead to abnormalities in cortisol metabolism in conditions like liver cirrhosis, extrahepatic biliary obstruction, and after ingestion of bile acids. + + Prednisolone is a synthetic glucocorticoid used primarily for its anti-inflammatory and immunosuppressive effects in various medical conditions such as allergies, asthma, autoimmune diseases, and certain types" +10527508,Prednisolone related to acute myeloid leukemia,257,"The plasma cortisol concentration was significantly higher in both DD groups before treatment than in the control group, and it decreased significantly after hoof trimming in the trimmed group.",False,"Is the triple 'Prednisolone related to acute myeloid leukemia' supported by the sentence: 'The plasma cortisol concentration was significantly higher in both DD groups before treatment than in the control group, and it decreased significantly after hoof trimming in the trimmed group.'?","No, the statement does not provide indirect support for the phrase ""Prednisolone related to acute myeloid leukemia."" The statement discusses changes in plasma cortisol concentration in response to hoof trimming in different groups but does not mention Prednisolone or acute myeloid leukemia at all. Prednisolone is a synthetic glucocorticoid often used as an anti-inflammatory agent, while acute myeloid leukemia is a type of cancer affecting blood cells; thus, there is no connection between them in this context." +10503828,Prednisolone related to seasonal allergic rhinitis,258,Hydrocortisone in culture protects the blast cells in acute myeloblastic leukemia from the lethal effects of cytosine arabinoside.,False,Is the triple 'Prednisolone related to seasonal allergic rhinitis' supported by the sentence: 'Hydrocortisone in culture protects the blast cells in acute myeloblastic leukemia from the lethal effects of cytosine arabinoside.'?,"No, the statement does not provide indirect support for the phrase ""Prednisolone related to seasonal allergic rhinitis."" The two statements discuss different topics: one is about hydrocortisone protecting blast cells in acute myeloblastic leukemia from cytosine arabinoside, while the other is about prednisolone being related to seasonal allergic rhinitis. + + The connection between glucocorticoids like hydrocortisone and prednisolone is that they both belong to the same class of steroid hormones that have anti-inflammatory effects. However, the statement about hydrocortisone does not mention any relation to allergic rhinitis nor does it imply anything about prednisolone specifically. To establish indirect support, there should be some common ground between the two statements that can lead from one to the other logically; in this case, there is no such connection." +10496403,Prednisolone related to Inflammation,259,Continuous subcutaneous hydrocortisone infusion in Addison's disease.,False,Is the triple 'Prednisolone related to Inflammation' supported by the sentence: 'Continuous subcutaneous hydrocortisone infusion in Addison's disease.'?,"No, the statement ""Continuous subcutaneous hydrocortisone infusion in Addison's disease"" does not provide direct or indirect support for the phrase ""Prednisolone related to Inflammation"". + + The statement discusses the use of hydrocortisone in treating Addison's disease, which is a condition characterized by insufficient production of hormones by the adrenal glands. Hydrocortisone is a type of corticosteroid that can help replace missing hormones in Addison's disease but it is not synonymous with Prednisolone. + + Prednisolone is another type of corticosteroid often used for its potent anti-inflammatory effects. The connection between Prednisolone and inflammation is direct because Prednisolone works by reducing inflammation in the body. However, the statement provided does not mention Prednisolone or its effects on inflammation. Therefore, it does not support the claim that Prednisolone is related to inflammation." +10118116,Prednisolone related to Prednisone,260,The current findings underline the relevance of cortisol and DHEA assessments and the need for further scrutiny of their interplay to foster our understanding of the biological basis of stress regulation in BPD.,False,Is the triple 'Prednisolone related to Prednisone' supported by the sentence: 'The current findings underline the relevance of cortisol and DHEA assessments and the need for further scrutiny of their interplay to foster our understanding of the biological basis of stress regulation in BPD.'?,"No, the statement does not provide indirect support for the phrase ""Prednisolone related to Prednisone."" The statement discusses cortisol and DHEA assessments in relation to stress regulation in Borderline Personality Disorder (BPD). Prednisolone and Prednisone are both corticosteroids used in medical treatments but they are not directly related in this context. Therefore, the provided statement does not lend credence to the relationship between Prednisolone and Prednisone." +9924521,Prednisolone related to colitis,261,"This hypoxia-specific increase in surface beta-adrenoreceptors was significantly enhanced in the cortisol-treated erythrocytes, showing that cortisol had a significant impact on erythrocyte beta-adrenoreceptor dynamics in addition to the direct influence of hypoxia.",False,"Is the triple 'Prednisolone related to colitis' supported by the sentence: 'This hypoxia-specific increase in surface beta-adrenoreceptors was significantly enhanced in the cortisol-treated erythrocytes, showing that cortisol had a significant impact on erythrocyte beta-adrenoreceptor dynamics in addition to the direct influence of hypoxia.'?","No, the statement ""This hypoxia-specific increase in surface beta-adrenoreceptors was significantly enhanced in the cortisol-treated erythrocytes, showing that cortisol had a significant impact on erythrocyte beta-adrenoreceptor dynamics in addition to the direct influence of hypoxia"" does not provide indirect support for the phrase ""Prednisolone related to colitis."" + + The statement discusses an experiment involving cortisol treatment on erythrocytes under hypoxic conditions and its effect on beta-adrenoreceptor dynamics. Prednisolone is a synthetic glucocorticoid often used in medical practice as an anti-inflammatory agent and shares structural similarities with cortisol; however, it is not identical to cortisol in terms of its physiological effects. + + The provided evidence focuses on cortisol's impact on erythrocyte beta-adrenoreceptor dynamics under hypoxic conditions; it does not mention colitis nor any link between cortisol (or Prednisolone) and colitis. As colitis is not mentioned in the statement, there is" +9437304,Prednisolone related to systemic lupus erythematosus,262,"Congenital adrenal hyperplasia (CAH) due to deficiency of 21-hydroxylase is a disorder of the adrenal cortex characterised by cortisol deficiency, with or without aldosterone deficiency, and androgen excess.",False,"Is the triple 'Prednisolone related to systemic lupus erythematosus' supported by the sentence: 'Congenital adrenal hyperplasia (CAH) due to deficiency of 21-hydroxylase is a disorder of the adrenal cortex characterised by cortisol deficiency, with or without aldosterone deficiency, and androgen excess.'?","No, the statement does not provide indirect support for the phrase ""Prednisolone related to systemic lupus erythematosus"". The statement discusses congenital adrenal hyperplasia (CAH) due to deficiency of 21-hydroxylase, which is an entirely different medical condition from systemic lupus erythematosus (SLE). Prednisolone is a glucocorticoid often used in treating SLE due to its anti-inflammatory effects; however, CAH is not typically treated with Prednisolone but rather mineralocorticoids and glucocorticoids in general due to their ability to replace deficient cortisol. + + The two conditions have different etiologies as well; CAH is caused by genetic mutations leading to enzyme deficiencies in cortisol synthesis in contrast to SLE being an autoimmune condition where the immune system attacks healthy tissue in the body. Therefore, no meaningful connection can be drawn between Prednisolone usage in SLE treatment and CAH pathophysiology based on the provided statement alone." +9282196,Prednisolone related to IgA glomerulonephritis,263,"Changes of smoking behavior and serum adrenocorticotropic hormone, cortisol, prolactin, and endogenous opioids levels in nicotine dependence after naltrexone treatment.",False,"Is the triple 'Prednisolone related to IgA glomerulonephritis' supported by the sentence: 'Changes of smoking behavior and serum adrenocorticotropic hormone, cortisol, prolactin, and endogenous opioids levels in nicotine dependence after naltrexone treatment.'?","No, there is no direct or indirect support for the phrase ""Prednisolone related to IgA glomerulonephritis"" in the provided statement about changes in hormone levels after naltrexone treatment in nicotine dependence. This statement does not mention prednisolone, IgA glomerulonephritis, or any related concepts that would provide contextual support for the original phrase." +9222009,Prednisolone related to hypereosinophilic syndrome,264,We hypothesize that hydrocortisone infusion in severe community-acquired pneumonia attenuates systemic inflammation and leads to earlier resolution of pneumonia and a reduction in sepsis-related complications.,False,Is the triple 'Prednisolone related to hypereosinophilic syndrome' supported by the sentence: 'We hypothesize that hydrocortisone infusion in severe community-acquired pneumonia attenuates systemic inflammation and leads to earlier resolution of pneumonia and a reduction in sepsis-related complications.'?,"No, the statement does not provide direct or indirect support for the phrase ""Prednisolone related to hypereosinophilic syndrome"". The hypothesis presented in the statement is about hydrocortisone infusion in severe community-acquired pneumonia, its effects on systemic inflammation, and potential outcomes such as earlier resolution of pneumonia and reduction in sepsis-related complications. Prednisolone is a different glucocorticoid medication than hydrocortisone, and hypereosinophilic syndrome is a distinct medical condition characterized by high levels of eosinophils in the blood and tissues. Therefore, there is no clear connection between the two statements based on the information provided." +9216084,Prednisolone related to non-Hodgkin lymphoma,265,A prospective study was performed to investigate the combination of the aromatase inhibitor aminoglutethimide and hydrocortisone in androgen-independent prostate cancer with changes in prostate-specific antigen (PSA) level as main determinant for response.,False,Is the triple 'Prednisolone related to non-Hodgkin lymphoma' supported by the sentence: 'A prospective study was performed to investigate the combination of the aromatase inhibitor aminoglutethimide and hydrocortisone in androgen-independent prostate cancer with changes in prostate-specific antigen (PSA) level as main determinant for response.'?,"No, the statement does not provide indirect support for the phrase ""Prednisolone related to non-Hodgkin lymphoma."" The prospective study in question investigates the combination of aromatase inhibitor aminoglutethimide and hydrocortisone in treating androgen-independent prostate cancer. Prednisolone is not mentioned in the study, nor is there any connection made between the treatment regimen and non-Hodgkin lymphoma. Therefore, it is inappropriate to infer any relationship between Prednisolone and non-Hodgkin lymphoma based on this information alone." +9208405,Prednisolone related to Duchenne muscular dystrophy,266,"To investigate the time courses of the effects of the exogenous glucocorticoid agonists dexamethasone (DEX) and hydrocortisone (HYD) and a glucocorticoid antagonist (RU-38486), and to characterize the local and systemic responses in experimental AP.",False,"Is the triple 'Prednisolone related to Duchenne muscular dystrophy' supported by the sentence: 'To investigate the time courses of the effects of the exogenous glucocorticoid agonists dexamethasone (DEX) and hydrocortisone (HYD) and a glucocorticoid antagonist (RU-38486), and to characterize the local and systemic responses in experimental AP.'?","No, the statement does not provide indirect support for the phrase ""Prednisolone related to Duchenne muscular dystrophy."" The statement discusses an investigation into the effects of certain glucocorticoid agonists (dexamethasone and hydrocortisone) and an antagonist (RU-38486) in experimental acute pancreatitis (AP), but it does not mention Prednisolone nor Duchenne muscular dystrophy. Prednisolone is a synthetic glucocorticoid often used in treating various inflammatory diseases; however, without further evidence linking it specifically to Duchenne muscular dystrophy in this context, there is no basis for such a connection based on the provided statement alone." +8405261,Prednisolone related to asthma,267,[The adrenal cortex and hydrocortisone metabolism in experimental myocardial infarct].,False,Is the triple 'Prednisolone related to asthma' supported by the sentence: '[The adrenal cortex and hydrocortisone metabolism in experimental myocardial infarct].'?,"No, the statement ""The adrenal cortex and hydrocortisone metabolism in experimental myocardial infarct"" does not provide indirect support for the phrase ""Prednisolone related to asthma."" The statement discusses the adrenal cortex and hydrocortisone metabolism in the context of experimental myocardial infarct (heart attack). Prednisolone is a synthetic glucocorticoid often used for its anti-inflammatory effects in various conditions such as asthma; however, it is not mentioned nor implied in the provided statement. The two statements discuss different topics: one is about heart conditions, while the other is about asthma treatment, hence they do not lend support to each other." +7844202,Prednisolone related to chronic obstructive pulmonary disease,268,[Intraarticular hydrocortisone (cortril) in arthritis and osteoarthritis].,False,Is the triple 'Prednisolone related to chronic obstructive pulmonary disease' supported by the sentence: '[Intraarticular hydrocortisone (cortril) in arthritis and osteoarthritis].'?,"No, the statement does not provide indirect support for the phrase ""Prednisolone related to chronic obstructive pulmonary disease"" (COPD). The reason is that the statement refers specifically to intraarticular hydrocortisone (Cortril) usage in arthritis and osteoarthritis, which is different from prednisolone and has no direct relation to chronic obstructive pulmonary disease. + + While prednisolone is also a corticosteroid like hydrocortisone, they have different therapeutic indications and administration routes. Prednisolone is more commonly used systemically for its anti-inflammatory effects in various conditions such as asthma, allergies, and autoimmune disorders. In contrast, intraarticular hydrocortisone is used primarily for local anti-inflammatory action in joint diseases like arthritis and osteoarthritis. + + In addition, chronic obstructive pulmonary disease is not typically treated with corticosteroids like prednisolone unless there is evidence of exacerbations or frequent symptoms, as long-term corticosteroid usage can" +7323744,Prednisolone related to pemphigus,269,[Use of cortisone and hydrocortisone in eye diseases].,False,Is the triple 'Prednisolone related to pemphigus' supported by the sentence: '[Use of cortisone and hydrocortisone in eye diseases].'?,"No, the statement ""Use of cortisone and hydrocortisone in eye diseases"" does not provide direct or indirect support for the phrase ""Prednisolone related to pemphigus."" Cortisone, hydrocortisone, and prednisolone belong to a class of drugs called corticosteroids, but they have different specific uses in medicine. Pemphigus is an autoimmune disorder that can be treated with corticosteroids like prednisolone; however, cortisone and hydrocortisone are not typically used for treating pemphigus due to their shorter duration of action compared to prednisolone. Therefore, while these drugs share some similarities in their pharmacological actions as corticosteroids, they have distinct applications in various medical contexts." +7262473,Prednisolone related to rheumatoid arthritis,270,[Topical use of hydrocortisone in otitis externa].,False,Is the triple 'Prednisolone related to rheumatoid arthritis' supported by the sentence: '[Topical use of hydrocortisone in otitis externa].'?,"No, the statement ""Topical use of hydrocortisone in otitis externa"" does not provide direct or indirect support for the phrase ""Prednisolone related to rheumatoid arthritis."" + + + + Hydrocortisone is a type of corticosteroid used topically for various inflammatory conditions such as otitis externa (ear infection). Prednisolone is also a corticosteroid but is often used systemically (orally) for conditions like rheumatoid arthritis due to its potent anti-inflammatory properties. + + + + Although both compounds belong to the same class (corticosteroids) and share some therapeutic effects (anti-inflammatory), they have different indications based on their specific pharmacological profiles. Therefore, the provided statement about hydrocortisone use in otitis externa does not lend any evidential support for prednisolone being related to rheumatoid arthritis. + + + + Nonetheless, it is essential to acknowledge that corticosteroids can be used off-" +7206314,Prednisolone related to pulmonary tuberculosis,271,The use of hydrocortisone in ulcerative colitis: preliminary observations.,False,Is the triple 'Prednisolone related to pulmonary tuberculosis' supported by the sentence: 'The use of hydrocortisone in ulcerative colitis: preliminary observations.'?,"No, the statement ""The use of hydrocortisone in ulcerative colitis: preliminary observations"" does not provide direct or indirect support for the phrase ""Prednisolone related to pulmonary tuberculosis."" + + + + The statement discusses the use of hydrocortisone in treating ulcerative colitis, which is an inflammatory bowel disease. Hydrocortisone is a type of corticosteroid, similar to prednisolone, but they have different properties and uses in medicine. + + + + Although both hydrocortisone and prednisolone belong to the same class of drugs (corticosteroids), they have distinct clinical applications. The statement does not mention pulmonary tuberculosis nor prednisolone; therefore, it does not offer any support for the connection between prednisolone and pulmonary tuberculosis. + + + + To establish a connection between prednisolone and pulmonary tuberculosis, one would need evidence from studies specifically investigating their relationship, such as those assessing prednisolone's impact on tuberculosis progress" +8856354,Prednisolone related to Prednisone,272,It can therefore be concluded that ointments containing either only E. coli BCS or a combination of BCS and hydrocortisone provide significant relief in perianal eczema as well as in early stages of hemorrhoidal disease.,False,Is the triple 'Prednisolone related to Prednisone' supported by the sentence: 'It can therefore be concluded that ointments containing either only E. coli BCS or a combination of BCS and hydrocortisone provide significant relief in perianal eczema as well as in early stages of hemorrhoidal disease.'?,"No, the statement does not provide indirect support for the phrase ""Prednisolone related to Prednisone"". The statement discusses the effectiveness of ointments containing Escherichia coli BCS (BCS) alone or in combination with hydrocortisone in treating perianal eczema and early stages of hemorrhoidal disease. Prednisolone and Prednisone are both corticosteroids but unrelated to E. coli BCS or hydrocortisone in this context. The provided statement does not mention these corticosteroids nor imply any connection between them." +26879702,Prednisolone has part acute lymphoblastic leukemia,273,The effect on cortisol supports the above conclusion and is consistent with HPA axis perturbation in opioid dependence as reported in other studies and extends these observations to stable methadone-maintained patients.,False,Is the triple 'Prednisolone has part acute lymphoblastic leukemia' supported by the sentence: 'The effect on cortisol supports the above conclusion and is consistent with HPA axis perturbation in opioid dependence as reported in other studies and extends these observations to stable methadone-maintained patients.'?,"No, the statement does not provide indirect support for the phrase ""Prednisolone has part acute lymphoblastic leukemia"". The statement discusses cortisol levels in opioid-dependent individuals who are on methadone maintenance therapy, which is not related to Prednisolone or acute lymphoblastic leukemia (ALL). Prednisolone is a synthetic glucocorticoid used for various medical purposes such as inflammation reduction but it is not known for its association with ALL. Thus, there is no connection between cortisol levels in opioid-dependent patients and Prednisolone-induced ALL mentioned in the statement." +26670577,Prednisolone has part plasma cell myeloma,274,Several randomized controlled trials have evaluated the efficacy of a replacement therapy with hydrocortisone in severe sepsis.,False,Is the triple 'Prednisolone has part plasma cell myeloma' supported by the sentence: 'Several randomized controlled trials have evaluated the efficacy of a replacement therapy with hydrocortisone in severe sepsis.'?,"No, the statement does not provide indirect support for ""Prednisolone has part plasma cell myeloma."" The two statements discuss different topics: one is about hydrocortisone replacement therapy in sepsis patients (a disease where immune function is often impaired), while the other makes an unrelated claim about prednisolone being part plasma cell mytesoma (a type of cancer). + + Prednisolone is a synthetic glucocorticoid that has anti-inflammatory properties similar to hydrocortisone; however, neither statement provides any evidence linking these drugs to plasma cell myeloma. + + Furthermore, it is important to note that plasma cell myeloma is not composed ""of"" any drug; it is a malignant neoplasm characterized by proliferation of neoplastic plasma cells within bone marrow. Therefore, it is highly unlikely that any drug would be part of plasma cell myeloma." +18935086,Prednisolone coexists with Prednisone,275,[Diurnal variations in blood glucose and plasma cortisol in juvenile diabetes mellitus without ketoacidosis].,False,Is the triple 'Prednisolone coexists with Prednisone' supported by the sentence: '[Diurnal variations in blood glucose and plasma cortisol in juvenile diabetes mellitus without ketoacidosis].'?,"No, the statement does not provide indirect support for the phrase ""Prednisolone coexists with Prednisone."" The title refers to diurnal variations in blood glucose and plasma cortisol in juvenile diabetes mellitus without ketoacidosis. Prednisolone and Prednisone are both corticosteroids that can affect blood glucose levels; however, they are different medications that cannot ""coexist"" in a literal sense as they have similar but distinct chemical structures and uses in clinical settings. + + While both Prednisolone and Prednisone can increase blood glucose levels in patients due to their glucocorticoid activity, they have different pharmacokinetic profiles which means that they cannot be used simultaneously for therapeutic purposes as it would lead to unpredictable effects on plasma cortisol levels and overall patient response. + + Therefore, even though both drugs might have an indirect relationship through their shared impact on blood glucose and plasma cortisol levels in patients with juvenile diabetes mellitus, the statement does not offer any support for them ""coexisting"" together within an individual patient or context." +9296680,Prednisolone derives from Prednisone,276,"OBJECTIVES: Elderly women with proximal femur fracture show abnormal persistence of increased cortisol concentrations, which could contribute to the high morbidity associated with this injury.",False,"Is the triple 'Prednisolone derives from Prednisone' supported by the sentence: 'OBJECTIVES: Elderly women with proximal femur fracture show abnormal persistence of increased cortisol concentrations, which could contribute to the high morbidity associated with this injury.'?","No, the statement does not provide direct or indirect support for the phrase ""Prednisolone derives from Prednisone."" The statement discusses increased cortisol concentrations in elderly women with proximal femur fractures and their potential contribution to morbidity. + + Prednisolone and Prednisone are both synthetic glucocorticoids used in treating various medical conditions such as inflammation, allergies, and autoimmune disorders. Prednisone is metabolized in the liver into Prednisolone, its active metabolite. However, there is no mention of either Prednisolone or Prednisone in the provided statement; therefore, it does not offer any support for the relationship between these two compounds." +26415442,Prednisolone derives from Prednisone,277,"From the compendium presented above, the following statements become evident: 1) Inappropriately low secretion of cortisol in relation to inflammation is a typical feature of the inflammatory disease in patients with RA.",False,"Is the triple 'Prednisolone derives from Prednisone' supported by the sentence: 'From the compendium presented above, the following statements become evident: 1) Inappropriately low secretion of cortisol in relation to inflammation is a typical feature of the inflammatory disease in patients with RA.'?","No, the statement does not provide any direct or indirect support for the phrase ""Prednisolone derives from Prednisone."" The statement discusses a feature of rheumatoid arthritis (RA) patients but does not make any connection between Prednisolone and Prednisone. + + Prednisolone and Prednisone are both corticosteroids used in treating inflammation; however, they have different chemical structures due to variations in their side chains. Prednisone is metabolized into Prednisolone in the liver after absorption, but this is not implied in the statement provided. + + To establish whether Prednisolone derives from Prednisone based on available literature, one would need to look for evidence that demonstrates Prednisone metabolism into Prednisolone in vivo or in vitro studies, pharmacokinetic investigations, or other relevant experimental setups that demonstrate such a relationship between these two compounds explicitly." +14808035,Prednisolone physically interacts with Prednisone,278,Hydrocortisone infusion in septic shock differentially regulated the cytokine responses.,False,Is the triple 'Prednisolone physically interacts with Prednisone' supported by the sentence: 'Hydrocortisone infusion in septic shock differentially regulated the cytokine responses.'?,"No, the statement does not provide any direct or indirect support for the phrase ""Prednisolone physically interacts with Prednisone"". + + The statement discusses Hydrocortisone infusion in septic shock and its effect on cytokine responses. Hydrocortisone, Prednisolone, and Prednisone are all glucocorticoids, but they are still different molecules with distinct chemical structures and properties. + + The fact that one glucocorticoid (Hydrocortisone) interacts differently with certain biological processes (cytokine responses) in a specific context (septic shock) does not imply that another glucocorticoid (Prednisolone) physically interacts with a third glucocorticoid (Prednisone) in a general sense. + + To establish whether Prednisolone physically interacts with Prednisone would require specific experimental evidence demonstrating such an interaction at the molecular level, which is not provided in the statement." +9296682,Prednisolone physically interacts with Prednisone,279,"BACKGROUND: There is substantial evidence of dysregulation of cortisol secretion, hippocampal abnormalities, and memory deficits in schizophrenia and other psychotic disorders.",False,"Is the triple 'Prednisolone physically interacts with Prednisone' supported by the sentence: 'BACKGROUND: There is substantial evidence of dysregulation of cortisol secretion, hippocampal abnormalities, and memory deficits in schizophrenia and other psychotic disorders.'?","No, the statement does not provide any direct or indirect support for the phrase ""Prednisolone physically interacts with Prednisone."" The background statement discusses dysregulation of cortisol secretion, hippocampal abnormalities, and memory deficits in schizophrenia and other psychotic disorders but does not mention Prednisolone or Prednisone nor imply any interaction between them. Prednisolone and Prednisone are both corticosteroids that can influence cortisol secretion but do not physically interact as they have similar chemical structures." +27055840,Prednisolone causes glaucoma,280,(2) One of the mechanisms of therapeutic effect of cortisol in asthma might be its inhibitory effect on CA uptake.,False,Is the triple 'Prednisolone causes glaucoma' supported by the sentence: '(2) One of the mechanisms of therapeutic effect of cortisol in asthma might be its inhibitory effect on CA uptake.'?,"No, the statement does not provide indirect support for the claim that ""Prednisolone causes glaucoma."" Prednisolone is a synthetic glucocorticoid often used in treating various conditions such as asthma due to its anti-inflammatory properties. The mechanism mentioned in the statement refers to cortisol (a natural glucocorticoid) inhibiting catecholamine (CA) uptake in asthma treatment. + + Although Prednisolone shares similarities in its mechanism of action with cortisol, it does not automatically imply that Prednisolone leads to glaucoma. Glaucoma is primarily associated with increased intraocular pressure (IOP), which is not explicitly mentioned in either statement. Therefore, further evidence is required to establish any connection between Prednisolone use and glaucoma risk." +26677891,Prednisolone causes uveitis,281,"OBJECTIVE: To compare cortisol levels, diurnal cycles of cortisol, and reactivity of cortisol to psychological stress in fibromyalgia (FM) and rheumatoid arthritis (RA) patients in their natural environment, and to examine the effect on results of accounting for differences among the groups in psychological stress and other lifestyle and psychosocial variables.",False,"Is the triple 'Prednisolone causes uveitis' supported by the sentence: 'OBJECTIVE: To compare cortisol levels, diurnal cycles of cortisol, and reactivity of cortisol to psychological stress in fibromyalgia (FM) and rheumatoid arthritis (RA) patients in their natural environment, and to examine the effect on results of accounting for differences among the groups in psychological stress and other lifestyle and psychosocial variables.'?","No, the statement does not provide indirect support for the phrase ""Prednisolone causes uveitis."" The objective in question pertains to a study comparing cortisol levels, diurnal cycles, and reactivity in fibromyalgia (FM) and rheumatoid arthritis (RA) patients in their natural environment while accounting for differences in psychological stress and other lifestyle variables. Prednisolone is not mentioned in this objective; therefore, it does not offer any support for the claim that Prednisolone causes uveitis. Uveitis is an inflammation of the uvea—the middle layer of the eye—whereas Prednisolone is a corticosteroid commonly used to treat inflammation in various conditions; however, it can have side effects that include increased susceptibility to infections and cataracts but not necessarily uveitis. + + To further clarify, indirect support for ""Prednisolone causes uveitis"" would require evidence suggesting that Prednisolone increases the risk or likelihood of uveitis development in patients; it is not established by merely mentioning Prednisolone in the context of another study objective without any direct relation to uveitis" +25953223,Prednisolone causes kidney disorder,282,"OBJECTIVES: Recent data suggest that higher plasma cortisol may be associated with hypertension and insulin resistance in otherwise healthy men, as it is in Cushing's syndrome.",False,"Is the triple 'Prednisolone causes kidney disorder' supported by the sentence: 'OBJECTIVES: Recent data suggest that higher plasma cortisol may be associated with hypertension and insulin resistance in otherwise healthy men, as it is in Cushing's syndrome.'?","No, the statement does not provide indirect support for the phrase ""Prednisolone causes kidney disorder."" The objective provided in the statement discusses recent data suggesting an association between higher plasma cortisol levels and hypertension and insulin resistance in otherwise healthy men, similar to Cushing's syndrome. Prednisolone is a synthetic glucocorticoid that can increase cortisol levels in the body; however, it does not specifically mention any kidney disorders associated with Prednisolone use in the statement provided. Therefore, further evidence would be required to establish such a link between Prednisolone use and kidney disorders." +21556285,Prednisolone causes allergic disease,283,"These findings demonstrate 2 types of adrenal insufficiency with different clinical pictures: Type 1 is characterized by cortisol deficiency with hypoglycaemia, low corticoid levels and a low cortisol secretion rate; Type 2 shows aldosterone deficiency with prominent salt loss.",False,"Is the triple 'Prednisolone causes allergic disease' supported by the sentence: 'These findings demonstrate 2 types of adrenal insufficiency with different clinical pictures: Type 1 is characterized by cortisol deficiency with hypoglycaemia, low corticoid levels and a low cortisol secretion rate; Type 2 shows aldosterone deficiency with prominent salt loss.'?","No, the statement does not provide indirect support for the phrase ""Prednisolone causes allergic disease"". The statement discusses two types of adrenal insufficiency but does not mention or imply any connection to Prednisolone or allergic disease. Prednisolone is a synthetic glucocorticoid often used in treating various conditions such as inflammation, allergies, and autoimmune disorders by suppressing immune response; however, it does not inherently cause allergic disease. Misinterpretation could lead to incorrect conclusions about Prednisolone's effects and potential misuse of the medication in clinical settings." +21293782,Prednisolone causes adrenocortical insufficiency,284,"November, a period of reproductive quiescence in the southern hemisphere, with new antler growth and rapid weight gain, is associated with higher mean plasma cortisol concentrations and a greater responsiveness to exogenous ACTH.",False,"Is the triple 'Prednisolone causes adrenocortical insufficiency' supported by the sentence: 'November, a period of reproductive quiescence in the southern hemisphere, with new antler growth and rapid weight gain, is associated with higher mean plasma cortisol concentrations and a greater responsiveness to exogenous ACTH.'?","No, the statement does not provide indirect support for the phrase ""Prednisolone causes adrenocortical insufficiency."" + + + + The statement discusses the relationship between reproductive quiescence in the southern hemisphere (November), higher mean plasma cortisol concentrations, and greater responsiveness to exogenous ACTH in animals during this period. Adrenocortical insufficiency refers to the inability of the adrenal glands to produce adequate amounts of steroid hormones such as cortisol and aldosterone in response to stress. Prednisolone is a synthetic glucocorticoid hormone that can suppress the natural production of cortisol in the body when administered at high doses for extended periods. + + + + While both statements discuss cortisol hormones, they represent different contexts: one is related to natural physiological changes during reproductive quiescence in animals, while the other refers to adrenocortical insufficiency caused by exogenous glucocorticoid administration in medical settings. Therefore, there is no indirect support for the claim that Prednisolone causes" +20789636,Prednisolone causes ulcerative colitis,285,Cortisol metabolism in human obesity: impaired cortisone-->cortisol conversion in subjects with central adiposity.,False,Is the triple 'Prednisolone causes ulcerative colitis' supported by the sentence: 'Cortisol metabolism in human obesity: impaired cortisone-->cortisol conversion in subjects with central adiposity.'?,"No, the statement ""Cortisol metabolism in human obesity: impaired cortisone-->cortisol conversion in subjects with central adiposity"" does not provide indirect support for the claim that ""Prednisolone causes ulcerative colitis."" + + Prednisolone is a synthetic glucocorticoid that is often used as an anti-inflammatory agent in treating various conditions, including ulcerative colitis. Cortisol is another glucocorticoid naturally produced in the human body by the adrenal glands in response to stress. The statement in question discusses an impairment in cortisone-to-cortisol conversion in obese individuals with central adiposity. + + Although both Prednisolone and cortisol have glucocorticoid activity, they have distinct mechanisms of action in vivo. Prednisolone is administered exogenously as a medication, while cortisol is endogenously produced in response to stress and other physiological signals. The study mentioned does not establish any direct link between Prednisolone use and ulcerative colitis development nor does it provide any evidence suggesting that" +17230021,Prednisolone causes Headache,286,The hypothalamic-pituitary-adrenal (HPA) axis is one of the key physiological systems that counterbalances this systemic inflammation through changes in adrenocorticotrophic hormone (ACTH) and cortisol.,False,Is the triple 'Prednisolone causes Headache' supported by the sentence: 'The hypothalamic-pituitary-adrenal (HPA) axis is one of the key physiological systems that counterbalances this systemic inflammation through changes in adrenocorticotrophic hormone (ACTH) and cortisol.'?,"No, the statement does not provide indirect support for ""Prednisolone causes Headache"". The connection between Prednisolone and headaches is not explicitly or implicitly mentioned in the provided information about the HPA axis, ACTH, cortisol, and systemic inflammation. + + Prednisolone is a synthetic glucocorticoid often used for its potent anti-inflammatory effects, which can influence the HPA axis by suppressing cortisol production in the long term. Headaches can be associated with various factors such as changes in intracranial pressure, vascular dilation, or medication side effects like Prednisolone. However, without additional evidence linking Prednisolone use specifically to headaches through its interaction with the HPA axis or other mechanisms, it is not possible to infer support for that claim based on the given statement." +16304261,Prednisolone causes nephrotic syndrome,287,"The 5 dpf hypoxic exposure also elicited transient increases in whole body cortisol and in crf, uts1, and hsd20b2 expression, key regulators of the endocrine stress response.",False,"Is the triple 'Prednisolone causes nephrotic syndrome' supported by the sentence: 'The 5 dpf hypoxic exposure also elicited transient increases in whole body cortisol and in crf, uts1, and hsd20b2 expression, key regulators of the endocrine stress response.'?","No, the statement does not provide direct or indirect support for the claim that Prednisolone causes nephrotic syndrome. The provided statement discusses the effects of hypoxic exposure on zebrafish at 5 days post-fertilization (dpf), focusing on increases in cortisol levels and expression of certain regulators involved in the endocrine stress response (crf, uts1, hsd20b2). There is no mention of Prednisolone or nephrotic syndrome in the statement. Therefore, it is not possible to draw any conclusions about the relationship between Prednisolone and nephrotic syndrome based on this information alone." +15365269,Prednisolone causes infertility disorder,288,"At multiple regression analyses, HOMA-IR on admission in the IR group significantly correlated with thyroid-stimulating hormone, glucagon, and cortisol.",False,"Is the triple 'Prednisolone causes infertility disorder' supported by the sentence: 'At multiple regression analyses, HOMA-IR on admission in the IR group significantly correlated with thyroid-stimulating hormone, glucagon, and cortisol.'?","No, the statement does not provide indirect support for the phrase ""Prednisolone causes infertility disorder."" The provided statement discusses correlations between certain factors in patients who have insulin resistance (IR group), including HOMA-IR (Homeostatic Model Assessment for Insulin Resistance), thyroid-stimulating hormone (TSH), glucagon, and cortisol levels on admission. However, there is no mention of Prednisolone in the statement nor any information linking these factors to infertility disorders. + + To provide indirect support for ""Prednisolone causes infertility disorder,"" there would need to be some evidence that Prednisolone affects fertility negatively in either humans or animal models. This evidence could be presented in various ways such as observing changes in hormone levels associated with fertility, reduced sperm count/motility in males, decreased ovarian function in females, or abnormalities in embryonic development during pregnancy. + + In summary, while it is essential to evaluate each piece of evidence carefully when interpreting scientific statements, in this case, there is no connection between Prednisolone use and infertility disorders based on the provided" +14373522,Prednisolone causes exfoliative dermatitis,289,"The suppression of the anti-inflammatory effects of cortisol as a result of states of excessive stress leads to hypercatabolic diseases such as AIDS, sepsis and toxic shock syndrome and protein calorie malnutrition (NAIDS).",False,"Is the triple 'Prednisolone causes exfoliative dermatitis' supported by the sentence: 'The suppression of the anti-inflammatory effects of cortisol as a result of states of excessive stress leads to hypercatabolic diseases such as AIDS, sepsis and toxic shock syndrome and protein calorie malnutrition (NAIDS).'?","No, the statement does not provide indirect support for ""Prednisolone causes exfoliative dermatitis."" The statement discusses the suppression of anti-inflammatory effects of cortisol in relation to certain diseases but does not mention prednisolone or exfoliative dermatitis. Prednisolone is a synthetic glucocorticoid used for its anti-inflammatory effects in various medical conditions; however, its use can lead to side effects such as skin rashes, but not specifically exfoliative dermatitis. Therefore, while there is a connection between corticosteroids (including prednisolone) and skin issues, it does not provide support for the initial claim." +10735861,Prednisolone causes contact dermatitis,290,"The suppression of the anti-inflammatory effects of cortisol as a result of states of excessive stress leads to hypercatabolic diseases such as AIDS, sepsis and toxic shock syndrome and protein calorie malnutrition (NAIDS).",False,"Is the triple 'Prednisolone causes contact dermatitis' supported by the sentence: 'The suppression of the anti-inflammatory effects of cortisol as a result of states of excessive stress leads to hypercatabolic diseases such as AIDS, sepsis and toxic shock syndrome and protein calorie malnutrition (NAIDS).'?","No, the statement does not provide indirect support for the phrase ""Prednisolone causes contact dermatitis."" The statement discusses the suppression of anti-inflammatory effects of cortisol in states of excessive stress leading to certain diseases (NAIDS), but it does not mention Prednisolone or contact dermatitis at all. Prednisolone is a synthetic glucocorticoid used primarily for its anti-inflammatory properties in various medical conditions; contact dermatitis is an allergic skin reaction that may be caused by various substances but is not known to be caused by Prednisolone itself when used properly as prescribed by medical professionals." +10545904,Prednisolone causes pulmonary tuberculosis,291,"We report the case of a 41-year-old nonatopic women with a previous history of eczematous reaction due to hydrocortisone who suffered worsening of her perennial rhinitis in association with perinasal dermatitis from the use of budesonide in nasal spray form, and stomatitis and pharyngitis due to budesonide in a bronchial inhaler.",False,"Is the triple 'Prednisolone causes pulmonary tuberculosis' supported by the sentence: 'We report the case of a 41-year-old nonatopic women with a previous history of eczematous reaction due to hydrocortisone who suffered worsening of her perennial rhinitis in association with perinasal dermatitis from the use of budesonide in nasal spray form, and stomatitis and pharyngitis due to budesonide in a bronchial inhaler.'?","No, the statement does not provide indirect support for the claim that Prednisolone causes pulmonary tuberculosis. The statement reports an adverse reaction in a patient using budesonide, which is a type of corticosteroid used in treating allergies and inflammation, similar to prednisolone. However, it does not mention pulmonary tuberculosis nor any link between the patient's symptoms and prednisolone use. + + The symptoms mentioned in the statement could be associated with various conditions, including infections, allergies, or irritations caused by budesonide itself. Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis and is not known to be caused by prednisolone use. Prednisolone is a corticosteroid that can suppress the immune system, making individuals more susceptible to infections but not causing them directly. + + In conclusion, while the statement highlights an adverse reaction in a patient using budesonide, it does not provide any evidence supporting the claim that prednisolone causes pulmonary tuberculosis." +10519611,Prednisolone causes colitis,292,"In this perspective paper, we focus on the neuro-endocrine interactions that occur between progesterone, allopregnanolone, and cortisol during pregnancy, and propose that they align with our previously proposed model of FM pathogenesis based on GABAergic ""weakening"" in a thalamocortical neural loop system.",False,"Is the triple 'Prednisolone causes colitis' supported by the sentence: 'In this perspective paper, we focus on the neuro-endocrine interactions that occur between progesterone, allopregnanolone, and cortisol during pregnancy, and propose that they align with our previously proposed model of FM pathogenesis based on GABAergic ""weakening"" in a thalamocortical neural loop system.'?","No, the statement does not provide indirect support for the phrase ""Prednisolone causes colitis."" The focus of the perspective paper is on neuro-endocrine interactions between progesterone, allopregnanolone, and cortisol during pregnancy, which is unrelated to prednisolone or colitis. Therefore, there is no basis in this statement for suggesting that prednisolone causes colitis." +9464043,Prednisolone causes cataract,293,The present study reported a case of hydrocortisone-induced blood pressure reduction in a patient with anterior pituitary hypofunction due to allergic reaction.,False,Is the triple 'Prednisolone causes cataract' supported by the sentence: 'The present study reported a case of hydrocortisone-induced blood pressure reduction in a patient with anterior pituitary hypofunction due to allergic reaction.'?,"No, the statement does not provide indirect support for the claim that ""Prednisolone causes cataract."" The study mentioned in the statement investigates hydrocortisone-induced blood pressure reduction in a patient suffering from anterior pituitary hypofunction due to an allergic reaction. Prednisolone is structurally and functionally different from hydrocortisone; they belong to different classes of corticosteroids (glucocorticoids). Therefore, any potential ocular side effects observed in patients treated with hydrocortisone cannot be readily generalized to another corticosteroid like prednisolone without further evidence linking them together. + + While both hydrocortisone and prednisolone have glucocorticoid activity and can cause side effects like cataracts, they differ in potency and duration of action. Hence, without concrete evidence specifically connecting prednisolone use to cataracts in patients, one cannot infer that prednisolone causes cataracts based on the given statement regarding hydrocortisone-induced blood pressure reduction in an allergic patient." +8757881,Prednisolone causes systemic lupus erythematosus,294,Fetal adrenocorticotropic hormone and cortisol increased to peak values within 2.8 hours of induced hypoxia but by 7.2 hours had begun to fall to values that were not significantly different from those at 1.4 hours.,False,Is the triple 'Prednisolone causes systemic lupus erythematosus' supported by the sentence: 'Fetal adrenocorticotropic hormone and cortisol increased to peak values within 2.8 hours of induced hypoxia but by 7.2 hours had begun to fall to values that were not significantly different from those at 1.4 hours.'?,"No, the statement does not provide indirect support for the phrase ""Prednisolone causes systemic lupus erythematosus."" The statement discusses fetal adrenocorticotropic hormone (ACTH) and cortisol levels in response to hypoxia, which is not directly related to Prednisolone or systemic lupus erythematosus (SLE). Prednisolone is a synthetic glucocorticoid used in various clinical settings for its potent anti-inflammatory effects while SLE is an autoimmune disease characterized by chronic inflammation due to loss of immune tolerance against self-antigens. While glucocorticoids like Prednisolone can have side effects including immune suppression, there is no direct causal relationship between Prednisolone use and development of SLE based on the provided information." +27658451,Prednisolone affects uveitis,295,Congenital adrenal hyperplasia (CAH) is a chronic condition and individuals are exposed to elevated androgen levels in utero as a result of the endogenous cortisol deficiency.,False,Is the triple 'Prednisolone affects uveitis' supported by the sentence: 'Congenital adrenal hyperplasia (CAH) is a chronic condition and individuals are exposed to elevated androgen levels in utero as a result of the endogenous cortisol deficiency.'?,"No, the statement does not provide direct or indirect support for the phrase ""Prednisolone affects uveitis."" The statement discusses congenital adrenal hyperplasia (CAH), a chronic condition that results in elevated androgen levels in utero due to endogenous cortisol deficiency. While prednisolone is often used as a treatment for CAH in order to manage cortisol levels, there is no mention in the statement about uveitis (inflammation of the middle layer of the eye) being affected by prednisolone treatment in individuals with CAH or otherwise. + + To provide indirect support for ""Prednisolone affects uveitis,"" there would need to be some link between CAH, prednisolone treatment, and uveitis in the statement. However, there is no such link provided in the statement given; therefore, it does not offer any support for the claim that prednisolone affects uveitis." +27410586,Prednisolone affects castration-resistant prostate carcinoma,296,The results of our study confirm that thymol has strong ameliorative effect against hydrocortisone-induced oxidative stress injury in hepatic tissues.,False,Is the triple 'Prednisolone affects castration-resistant prostate carcinoma' supported by the sentence: 'The results of our study confirm that thymol has strong ameliorative effect against hydrocortisone-induced oxidative stress injury in hepatic tissues.'?,"No, the statement does not provide indirect support for the phrase ""Prednisolone affects castration-resistant prostate carcinoma"". The study in question investigates the effects of thymol on hydrocortisone-induced oxidative stress injury in hepatic tissues, which is unrelated to prednisolone's potential impact on castration-resistant prostate carcinoma. Prednisolone is a synthetic glucocorticoid used primarily for its anti-inflammatory properties; it is not mentioned in the provided statement. Thus, there is no connection between thymol and prednisolone in terms of their respective effects on different biological systems. + + However, it is important to note that both prednisolone and hydrocortisone belong to the glucocorticoid class of steroid hormones; therefore, they might share some mechanisms related to their pharmacological activities in certain contexts. Nonetheless, without explicit evidence linking prednisolone to castration-resistant prostate carcinoma in conjunction with thymol or hydrocortisone-induced oxidative stress injury in hepatic t" +27323391,Prednisolone affects focal segmental glomerulosclerosis,297,The effects of 8-bromo-cyclic AMP and cyclic AMP agonists (cholera toxin plus hydrocortisone and prostaglandin E2 plus 3-isobutyl-1-methylxanthine) on the cytotoxic activity of T cells generated during murine influenza virus infection have been examined.,False,Is the triple 'Prednisolone affects focal segmental glomerulosclerosis' supported by the sentence: 'The effects of 8-bromo-cyclic AMP and cyclic AMP agonists (cholera toxin plus hydrocortisone and prostaglandin E2 plus 3-isobutyl-1-methylxanthine) on the cytotoxic activity of T cells generated during murine influenza virus infection have been examined.'?,"No, the statement does not provide indirect support for the phrase ""Prednisolone affects focal segmental glomerulosclerosis."" The statement discusses the effects of certain substances on T cell cytotoxic activity during murine influenza virus infection in mice, which is unrelated to Prednisolone and focal segmental glomerulosclerosis in humans. Prednisolone is a synthetic glucocorticoid used primarily for its anti-inflammatory effects in various disease states, while focal segmental glomerulosclerosis is a kidney disease characterized by scarring in specific areas of the kidney glomeruli. The connection between these two concepts is not established in the provided statement." +27042309,Prednisolone affects pulmonary eosinophilia,298,Open oral provocation with 100 or 250 mg hydrocortisone in patients with hydrocortisone contact hypersensitivity elicited cutaneous reactions at sites of previous allergic dermatitis caused by hydrocortisone in two patients and at sites of earlier allergic patch test reactions caused by hydrocortisone in the other two patients.,False,Is the triple 'Prednisolone affects pulmonary eosinophilia' supported by the sentence: 'Open oral provocation with 100 or 250 mg hydrocortisone in patients with hydrocortisone contact hypersensitivity elicited cutaneous reactions at sites of previous allergic dermatitis caused by hydrocortisone in two patients and at sites of earlier allergic patch test reactions caused by hydrocortisone in the other two patients.'?,"No, the statement does not provide direct or indirect support for the phrase ""Prednisolone affects pulmonary eosinophilia."" The statement discusses the effects of hydrocortisone on patients with hydrocortisone contact hypersensitivity, while prednisolone is a different glucocorticoid medication that may have distinct effects on various biological processes and organ systems such as pulmonary eosinophilia in different contexts. + + To establish support for ""Prednisolone affects pulmonary eosinophilia,"" evidence should be provided that demonstrates prednisolone's impact on eosinophilia in the pulmonary system specifically. In order for evidence about hydrocortisone to be relevant, it would need to show a clear connection between hydrocortisone and prednisolone in terms of their mechanisms, pharmacodynamics, or therapeutic effects on pulmonary eosinophilia. This connection is not apparent in the provided statement." +25790510,Prednisolone affects allergic disease,299,"Although initial studies in transgenic mice and humans are encouraging, more data are required to conclusively prove the hypothesis that the adipose-tissue-specific overexpression of HSD1 and the resultant increase in tissue-specific cortisol concentrations result in human obesity, insulin resistance, high blood pressure, and metabolic syndrome.",False,"Is the triple 'Prednisolone affects allergic disease' supported by the sentence: 'Although initial studies in transgenic mice and humans are encouraging, more data are required to conclusively prove the hypothesis that the adipose-tissue-specific overexpression of HSD1 and the resultant increase in tissue-specific cortisol concentrations result in human obesity, insulin resistance, high blood pressure, and metabolic syndrome.'?","No, the statement does not provide indirect support for the phrase ""Prednisolone affects allergic disease."" The statement discusses research on transgenic mice and humans regarding adipose-tissue-specific overexpression of HSD1 (11β-hydroxysteroid dehydrogenase type 1) and its impact on obesity, insulin resistance, high blood pressure, and metabolic syndrome. Prednisolone is a synthetic glucocorticoid used primarily for its potent anti-inflammatory effects in treating various conditions such as allergies; however, it is not mentioned nor implied in the statement provided. + + The two concepts—the effects of HSD1 overexpression on metabolic parameters and Prednisolone's impact on allergic disease—are distinct topics that require separate lines of evidence for support. Therefore, it is essential to evaluate each claim independently based on relevant and specific evidence related to each case." +25165576,Prednisolone affects glomerulonephritis,300,"CONCLUSION: Although hydrocortisone has anti-inflammatory properties, it seems to provoke inflammation in the round window membrane after topical instillation.",False,"Is the triple 'Prednisolone affects glomerulonephritis' supported by the sentence: 'CONCLUSION: Although hydrocortisone has anti-inflammatory properties, it seems to provoke inflammation in the round window membrane after topical instillation.'?","No, the statement does not provide indirect support for the phrase ""Prednisolone affects glomerulonephritis."" The conclusion in the statement discusses hydrocortisone's effect on the round window membrane after topical instillation, which is different from prednisolone and glomerulonephritis. Glomerulonephritis is a kidney disorder while the round window membrane is part of the inner ear anatomy; therefore, these conditions and treatments are not related. Prednisolone is a synthetic glucocorticoid like hydrocortisone but they have different therapeutic indications based on their specific properties. The provided statement does not contain any information linking prednisolone to glomerulonephritis; hence it does not offer any indirect support for that claim." +24270725,Prednisolone affects dermatomyositis,301,"Type 2 glucocorticoid receptors (GRs), which are occupied by cortisol in humans in times of stress, are thought to be responsible for the glucocorticoid-induced memory impairment.",False,"Is the triple 'Prednisolone affects dermatomyositis' supported by the sentence: 'Type 2 glucocorticoid receptors (GRs), which are occupied by cortisol in humans in times of stress, are thought to be responsible for the glucocorticoid-induced memory impairment.'?","No, the statement does not provide indirect support for the phrase ""Prednisolone affects dermatomyositis."" The statement discusses type 2 glucocorticoid receptors (GRs) and their role in glucocorticoid-induced memory impairment in humans during times of stress. Prednisolone is a synthetic glucocorticoid used in various medical conditions including dermatomyositis; however, the statement does not connect GRs in stress response with dermatomyositis or any therapeutic effect of prednisolone on it. + + To establish indirect support for ""Prednisolone affects dermatomyositis,"" additional information would be required that links GRs in dermatomyositis pathophysiology specifically, as well as prednisolone's action on these receptors in that context." +22922261,Prednisolone affects allergic bronchopulmonary aspergillosis,302,"Firstly, the GH-mediated increase in cortisol metabolism (mediated via reduced E to F conversion) may precipitate adrenal insufficiency in hypopituitary patients with partial adrenocorticotropic hormone deficiency commencing GH therapy.",False,"Is the triple 'Prednisolone affects allergic bronchopulmonary aspergillosis' supported by the sentence: 'Firstly, the GH-mediated increase in cortisol metabolism (mediated via reduced E to F conversion) may precipitate adrenal insufficiency in hypopituitary patients with partial adrenocorticotropic hormone deficiency commencing GH therapy.'?","No, the statement does not provide direct or indirect support for the phrase ""Prednisolone affects allergic bronchopulmonary aspergillosis."" The statement discusses the potential impact of growth hormone (GH) therapy on cortisol metabolism in hypopituitary patients, specifically those with partial adrenocorticotropic hormone deficiency. While prednisolone is a corticosteroid that can influence cortisol levels, the statement does not make any connection between prednisolone use and allergic bronchopulmonary aspergillosis (ABPA), which is an allergic reaction to the fungus Aspergillus that often affects individuals with cystic fibrosis or asthma. Therefore, further evidence would be required to establish a relationship between prednisolone use and ABPA." +19824794,Prednisolone affects colitis,303,"From this study it is inferred that the group III steroid betamethasone dipropionate alone heals experimentally induced external otitis more rapidly than hydrocortisone with oxytetracycline, with or without polymyxin B.",False,"Is the triple 'Prednisolone affects colitis' supported by the sentence: 'From this study it is inferred that the group III steroid betamethasone dipropionate alone heals experimentally induced external otitis more rapidly than hydrocortisone with oxytetracycline, with or without polymyxin B.'?","No, the statement does not provide direct or indirect support for the phrase ""Prednisolone affects colitis."" The study referenced in the statement investigates the effects of different steroids on external otitis, not colitis. Prednisolone is not mentioned in the statement, and even if it were, inference would still be needed to connect its impact on colitis due to the absence of explicit information about colitis in the statement." +19409335,Prednisolone affects sarcoidosis,304,"In conclusion, the reciprocal expression of CYP17 and the transcriptional repressors COUP-TF and DAX-1 indicates that these orphan receptors have a pathophysiologic role in the excessive hormone production in cortisol- and deoxycorticosterone-producing adrenocortical tumors.",False,"Is the triple 'Prednisolone affects sarcoidosis' supported by the sentence: 'In conclusion, the reciprocal expression of CYP17 and the transcriptional repressors COUP-TF and DAX-1 indicates that these orphan receptors have a pathophysiologic role in the excessive hormone production in cortisol- and deoxycorticosterone-producing adrenocortical tumors.'?","No, the statement does not provide direct or indirect support for the phrase ""Prednisolone affects sarcoidosis."" The conclusion in the statement is about the pathophysiologic role of CYP17 and transcriptional repressors COUP-TF and DAX-1 in cortisol- and deoxycorticosterone-producing adrenocortical tumors. Prednisolone is a synthetic glucocorticoid used primarily for its anti-inflammatory effects in various conditions such as asthma, rheumatoid arthritis, and COPD; it is not specifically mentioned in the context of sarcoidosis or adrenocortical tumors in this statement. + + To establish whether prednisolone affects sarcoidosis, one would need evidence from studies that investigate prednisolone use in sarcoidosis patients specifically. This may include randomized controlled trials (RCTs), cohort studies, or case-control studies that demonstrate an association between prednisolone use and sarcoidosis outcomes. As it stands, there is no clear link between prednisolone and sarcoidosis based on" +18736907,Prednisolone affects asthma,305,"The administration of hydrocortisone before tumor inoculation resulted in increased tumor take, reduced mean survival time of mice, and concentration of tumor metastasis in a specific organ (i.e., lung metastasis for Ehrlich hypotetraploid clone 1 tumor, and liver metastasis for Ehrlich hypotetraploid stock and Ehrlich hyperdiploid stock tumors).",False,"Is the triple 'Prednisolone affects asthma' supported by the sentence: 'The administration of hydrocortisone before tumor inoculation resulted in increased tumor take, reduced mean survival time of mice, and concentration of tumor metastasis in a specific organ (i.e., lung metastasis for Ehrlich hypotetraploid clone 1 tumor, and liver metastasis for Ehrlich hypotetraploid stock and Ehrlich hyperdiploid stock tumors).'?","No, the statement does not provide indirect support for the phrase ""Prednisolone affects asthma."" The statement discusses an experiment involving hydrocortisone administration in mice with specific types of tumors, but it does not mention Prednisolone nor asthma at all. Prednisolone is a synthetic glucocorticoid used in various medical conditions like asthma but unrelated to tumor growth in mice from the provided statement. + + To provide indirect support for ""Prednisolone affects asthma,"" there should be some connection between hydrocortisone/tumor growth in mice and Prednisolone/asthma in humans in terms of mechanism, shared biological pathways, or clinical relevance. In the absence of such connections, it is inappropriate to infer any relationship between Prednisolone and asthma based on the given statement alone." +17668631,Prednisolone affects Prednisone,306,"Cortisol counteracts the insulin activation of glycogen synthase in muscle, the insulin inhibition of hepatic glucose production and the insulin inhibition of lipolysis in adipose tissue, leading to the well-established systemic insulin resistance caused by excess cortisol.",False,"Is the triple 'Prednisolone affects Prednisone' supported by the sentence: 'Cortisol counteracts the insulin activation of glycogen synthase in muscle, the insulin inhibition of hepatic glucose production and the insulin inhibition of lipolysis in adipose tissue, leading to the well-established systemic insulin resistance caused by excess cortisol.'?","No, the statement does not provide indirect support for the phrase ""Prednisolone affects Prednisone."" + + The statement discusses the effects of cortisol on various metabolic processes in the body, specifically its impact on insulin resistance. Prednisolone and Prednisone are both synthetic glucocorticoids, which have similar effects on the body as cortisol due to their shared mechanism of action on glucocorticoid receptors. However, there is no mention in the statement about any interaction between Prednisolone and Prednisone themselves. Therefore, without further information about a direct or indirect relationship between these two drugs, we cannot infer that Prednisolone affects Prednisone based on this statement alone." +15888410,Prednisolone affects rheumatoid arthritis,307,"The amount of N-acetyl D-glucosamine in the zymogen granule membrane was not altered by caerulein acute pancreatitis induced under continuous hydrocortisone treatment, but it was decreased by the administration of L-364,718 over 7 days after pancreatitis induction.",False,"Is the triple 'Prednisolone affects rheumatoid arthritis' supported by the sentence: 'The amount of N-acetyl D-glucosamine in the zymogen granule membrane was not altered by caerulein acute pancreatitis induced under continuous hydrocortisone treatment, but it was decreased by the administration of L-364,718 over 7 days after pancreatitis induction.'?","No, the statement does not provide indirect support for the claim that ""Prednisolone affects rheumatoid arthritis."" The provided statement discusses changes in N-acetyl D-glucosamine levels in zymogen granule membranes under different conditions (continuous hydrocortisone treatment versus L-364,718 administration after pancreatitis induction). Rheumatoid arthritis is an autoimmune disorder, while caerulein acute pancreatitis is an inflammatory condition induced in animal models for experimental purposes. Prednisolone is indeed used in treating rheumatoid arthritis but addressing pancreatitis in an animal model does not provide evidence for its effectiveness in rheumatoid arthritis treatment. To provide indirect support for ""Prednisolone affects rheumatoid arthritis,"" there should be some connection between prednisolone, N-acetyl D-glucosamine levels (or zymogen granule membranes), and rheumatoid arthritis, which is absent in the given statement." +13564625,Prednisolone affects asthma,308,False elevation of plasma cortisol in congenital adrenal hyperplasia.,False,Is the triple 'Prednisolone affects asthma' supported by the sentence: 'False elevation of plasma cortisol in congenital adrenal hyperplasia.'?,"No, the statement ""False elevation of plasma cortisol in congenital adrenal hyperplasia"" does not provide direct or indirect support for the phrase ""Prednisolone affects asthma."" + + Prednisolone is a synthetic glucocorticoid drug often used in treating asthma due to its anti-inflammatory properties. It works by mimicking the natural hormone cortisol produced by the adrenal glands. Congenital adrenal hyperplasia (CAH) is a genetic disorder affecting the adrenal glands' ability to produce hormones like cortisol and aldosterone. In some forms of CAH, there can be false elevations in plasma cortisol due to issues in hormone processing. + + While both prednisolone and CAH involve cortisol hormones, they represent different contexts. The statement about CAH does not provide insights into prednisolone's effects on asthma since it discusses a specific pathological condition affecting hormone regulation rather than addressing prednisolone as a therapeutic intervention for asthma symptoms. + + To establish whether prednis" +13234063,Prednisolone affects pericarditis,309,Further studies evaluating the mechanism of action and long term effects of hydrocortisone in cardiac arrest need to be conducted.,False,Is the triple 'Prednisolone affects pericarditis' supported by the sentence: 'Further studies evaluating the mechanism of action and long term effects of hydrocortisone in cardiac arrest need to be conducted.'?,"No, the statement does not provide indirect support for the phrase ""Prednisolone affects pericarditis"". + + + + The statement discusses further studies needed on hydrocortisone in cardiac arrest, which is different from prednisolone and pericarditis. Hydrocortisone is a type of corticosteroid often used in treating conditions like cardiac arrest, while prednisolone is another corticosteroid used for various inflammatory and immune system disorders. Pericarditis refers to inflammation in the pericardium, the lining around the heart. + + + + Although these elements belong to the same general class of medications (corticosteroids) and share some similar properties, they have distinct effects on different physiological processes. Therefore, evidence suggesting that hydrocortisone has certain effects in cardiac arrest does not necessarily imply that prednisolone will impact pericarditis in the same way. + + + + To establish whether prednisolone affects pericarditis would require direct evidence linking prednisolone use with changes in pericarditis incidence, severity, or" +13029310,Prednisolone affects chronic obstructive pulmonary disease,310,"In acute MI, there were elevated plasma levels of cortisol depending on the MI severity with a small repeated peak of its increase on day 14 and its subsequent decrease, except deaths.",False,"Is the triple 'Prednisolone affects chronic obstructive pulmonary disease' supported by the sentence: 'In acute MI, there were elevated plasma levels of cortisol depending on the MI severity with a small repeated peak of its increase on day 14 and its subsequent decrease, except deaths.'?","No, the statement does not provide direct or indirect support for the phrase ""Prednisolone affects chronic obstructive pulmonary disease"" (COPD). The statement discusses the relationship between acute myocardial infarction (MI) severity and plasma cortisol levels but does not mention Prednisolone or COPD. Prednisolone is a synthetic glucocorticoid often used in treating inflammatory diseases such as COPD but is not mentioned in the provided statement. Therefore, no connection can be inferred between Prednisolone and COPD based on this statement alone." +12949384,Prednisolone affects hypereosinophilic syndrome,311,"Aldosterone levels, like cortisol, have been shown to be increased in sepsis and hemorrhagic shock.",False,"Is the triple 'Prednisolone affects hypereosinophilic syndrome' supported by the sentence: 'Aldosterone levels, like cortisol, have been shown to be increased in sepsis and hemorrhagic shock.'?","No, the statement does not provide indirect support for the phrase ""Prednisolone affects hypereosinophilic syndrome"". The relationship between aldosterone levels (a mineralocorticoid) and cortisol levels (a glucocorticoid), both being stress hormones affected by sepsis and hemorrhagic shock, is not directly related to Prednisolone, which is a synthetic glucocorticoid used primarily for its anti-inflammatory effects. Hypereosinophilic syndrome is characterized by an abnormal increase in eosinophils, a type of white blood cell. While glucocorticoids like Prednisolone can impact immune system functioning, there is no clear link provided between Prednisolone and hypereosinophilic syndrome based on these statements alone. + + To establish indirect support for ""Prednisolone affects hypereosinophilic syndrome"", one would need evidence showing that Prednisolone influences eosinophil counts or activity in some way – either increasing, decreasing, or otherwise altering their behavior – which is not provided in the given statement about aldosterone and cortis" +12057849,Prednisolone affects Crohn disease,312,"In this review, we summarize the effects of circadian melatonin, TSH, and cortisol on OA, focusing on how different levels of these hormones affect OA pathogenesis and recovery with respect to the circadian clock.",False,"Is the triple 'Prednisolone affects Crohn disease' supported by the sentence: 'In this review, we summarize the effects of circadian melatonin, TSH, and cortisol on OA, focusing on how different levels of these hormones affect OA pathogenesis and recovery with respect to the circadian clock.'?","No, the statement does not provide direct or indirect support for the claim that ""Prednisolone affects Crohn disease."" The review focuses on summarizing the effects of circadian melatonin, TSH (thyroid-stimulating hormone), and cortisol on osteoarthritis (OA). There is no mention of Prednisolone, which is a synthetic glucocorticoid used primarily for its anti-inflammatory properties in various diseases such as Crohn disease. Therefore, it is not possible to draw any conclusions about Prednisolone's effects on Crohn disease based on this statement alone. + + However, it is important to note that cortisol is also a glucocorticoid like Prednisolone, so there might be some overlap in their mechanisms in terms of anti-inflammatory effects in certain conditions like Crohn disease. Nonetheless, more specific evidence is required to validate such connections between Prednisolone and Crohn disease." +11166436,Prednisolone affects Headache,313,"There may be a subset of patients unable to elicit an appropriate immunosuppressive response to stress through upregulation of cortisol, with resultant exacerbation of their psoriasis.",False,"Is the triple 'Prednisolone affects Headache' supported by the sentence: 'There may be a subset of patients unable to elicit an appropriate immunosuppressive response to stress through upregulation of cortisol, with resultant exacerbation of their psoriasis.'?","No, the statement does not provide direct or indirect support for the phrase ""Prednisolone affects Headache."" The statement discusses a potential subset of patients who cannot appropriately respond immunosuppressively to stress due to insufficient cortisol upregulation leading to psoriasis exacerbation. Prednisolone is a synthetic glucocorticoid used primarily for its potent anti-inflammatory effects in various conditions such as psoriasis; however, it does not mention any connection between Prednisolone use and headaches. + + Although stress and cortisol levels have been linked to migraines and headaches in some studies, there is no explicit information in the given statement that links Prednisolone use to headache relief or exacerbation. Furthermore, Prednisolone is known to have side effects that include headaches; however, this is not explicitly mentioned in the statement either. Therefore, it is not possible to infer any relationship between Prednisolone use and headaches based solely on the provided statement." +11074135,Prednisolone affects lymphoma,314,"In addition to local effect, topical hydrocortisone therapy of childhood dermatitis is accompanied by a systemic effect that may be pronounced in the acute phase of disease.",False,"Is the triple 'Prednisolone affects lymphoma' supported by the sentence: 'In addition to local effect, topical hydrocortisone therapy of childhood dermatitis is accompanied by a systemic effect that may be pronounced in the acute phase of disease.'?","No, the statement does not provide direct or indirect support for the phrase ""Prednisolone affects lymphoma"". The statement discusses the systemic effect of topical hydrocortisone therapy in childhood dermatitis, which is not related to lymphoma or Prednisolone. Prednisolone is a synthetic glucocorticoid often used in the treatment of various conditions including lymphoma, but the statement provided does not offer any information about Prednisolone's effect on lymphoma." +10651502,Prednisolone affects kidney disorder,315,"They answered the Fibromyalgia Impact Questionnaire (FIQ), Perceived Stress Questionnaire (PSQ) and McGill Pain Questionnaire (MPQ-Br), and collected saliva to evaluate CC before and after the end of each month.",False,"Is the triple 'Prednisolone affects kidney disorder' supported by the sentence: 'They answered the Fibromyalgia Impact Questionnaire (FIQ), Perceived Stress Questionnaire (PSQ) and McGill Pain Questionnaire (MPQ-Br), and collected saliva to evaluate CC before and after the end of each month.'?","No, the statement does not provide direct or indirect support for the phrase ""Prednisolone affects kidney disorder."" The provided information pertains to patients answering questionnaires about fibromyalgia impact, perceived stress, and pain; in addition to saliva collection for cortisol evaluation before and after each month. There is no mention of prednisolone use nor kidney disorder in the statement." +10649036,Prednisolone affects chorioretinitis,316,"BACKGROUND: The hypothalamic-pituitary-adrenal stress axis plays a crucial role in community-acquired pneumonia (CAP), with high cortisol being associated with disease severity and corticosteroid treatment resulting in earlier time to recovery.",True,"Is the triple 'Prednisolone affects chorioretinitis' supported by the sentence: 'BACKGROUND: The hypothalamic-pituitary-adrenal stress axis plays a crucial role in community-acquired pneumonia (CAP), with high cortisol being associated with disease severity and corticosteroid treatment resulting in earlier time to recovery.'?","Yes, indirect support can be inferred from the statement provided for the claim ""Prednisolone affects chorioretinitis"". This is because Prednisolone is a synthetic glucocorticoid that acts on the hypothalamic-pituitary-adrenal (HPA) axis which plays a crucial role in community-acquired pneumonia (CAP). The statement highlights that corticosteroid treatment (which includes Prednisolone) results in earlier time to recovery in CAP patients who have high cortisol levels associated with disease severity. + + + + However, chorioretinitis is an inflammation of the choroid and retina in the eye which is not explicitly mentioned in the background information. Nonetheless, glucocorticoids like Prednisolone have been widely used in managing various ocular inflammatory conditions due to their potent anti-inflammatory effects on immune cells as well as their ability to stabilize blood-ocular barriers. Therefore, it is plausible that Prednisolone could affect chorioretinitis indirectly through its influence on immune responses and inflammation." +10555139,Prednisolone affects peptic ulcer disease,317,"The incidence of AF was compared among patients who received hydrocortisone, and the effect of low-dose hydrocortisone on AF was estimated using the inverse probability treatment weighting method based on propensity scores.",False,"Is the triple 'Prednisolone affects peptic ulcer disease' supported by the sentence: 'The incidence of AF was compared among patients who received hydrocortisone, and the effect of low-dose hydrocortisone on AF was estimated using the inverse probability treatment weighting method based on propensity scores.'?","No, the statement does not provide direct or indirect support for the claim that ""Prednisolone affects peptic ulcer disease."" The provided statement compares the incidence of atrial fibrillation (AF) among patients who received hydrocortisone and estimates its effect using a specific statistical method. There is no mention of prednisolone or peptic ulcer disease in this context. Therefore, it does not contribute any relevant evidence towards that specific claim." +10183156,Prednisolone affects ulcerative colitis,318,"INTRODUCTION: Intrathecal administration of methotrexate, cytarabine, and hydrocortisone is commonly used to treat and prevent central nervous system involvement in leukemias and lymphomas.",False,"Is the triple 'Prednisolone affects ulcerative colitis' supported by the sentence: 'INTRODUCTION: Intrathecal administration of methotrexate, cytarabine, and hydrocortisone is commonly used to treat and prevent central nervous system involvement in leukemias and lymphomas.'?","No, the statement does not provide indirect support for the phrase ""Prednisolone affects ulcerative colitis."" The introduction mentions intrathecal administration (injection into the spinal canal) of methotrexate, cytarabine, and hydrocortisone for treating central nervous system involvement in leukemias and lymphomas; however, it does not mention prednisolone nor ulcerative colitis. Prednisolone is a synthetic glucocorticoid used primarily for its anti-inflammatory effect in various conditions like asthma, allergies, arthritis, and dermatological diseases; ulcerative colitis is a type of inflammatory bowel disease that may be treated with other corticosteroids such as budesonide or hydrocortisone but not necessarily prednisolone." +9735520,Prednisolone affects Inflammation,319,"INTRODUCTION: Intrathecal administration of methotrexate, cytarabine, and hydrocortisone is commonly used to treat and prevent central nervous system involvement in leukemias and lymphomas.",False,"Is the triple 'Prednisolone affects Inflammation' supported by the sentence: 'INTRODUCTION: Intrathecal administration of methotrexate, cytarabine, and hydrocortisone is commonly used to treat and prevent central nervous system involvement in leukemias and lymphomas.'?","No, the statement does not provide direct or indirect support for the phrase ""Prednisolone affects Inflammation."" The introductory statement discusses the combined use of methotrexate, cytarabine, and hydrocortisone for treating central nervous system involvement in leukemias and lymphomas; however, it does not mention Prednisolone or Inflammation specifically. While hydrocortisone is a type of steroid that can influence inflammation like Prednisolone, it is not explicitly stated that Prednisolone is used for its anti-inflammatory properties in this context. Therefore, no valid conclusion can be drawn regarding Prednisolone's effect on inflammation based on this statement alone." +9361682,Prednisolone affects osteoarthritis,320,"CONCLUSIONS: Early PN did not affect plasma concentrations of ACTH and (free) cortisol, but increased the incidence of septic shock, which statistically explained why more patients on early PN received corticosteroids.",False,"Is the triple 'Prednisolone affects osteoarthritis' supported by the sentence: 'CONCLUSIONS: Early PN did not affect plasma concentrations of ACTH and (free) cortisol, but increased the incidence of septic shock, which statistically explained why more patients on early PN received corticosteroids.'?","No, the statement does not provide direct or indirect support for the phrase ""Prednisolone affects osteoarthritis."" The conclusion is about early parenteral nutrition (PN) affecting plasma concentrations of adrenocorticotropic hormone (ACTH) and cortisol, as well as its impact on septic shock incidence leading to more corticosteroid use in patients on early PN. Prednisolone is not mentioned in the conclusion, nor is there any connection established between PN and osteoarthritis or osteoarthritis and prednisolone use. Therefore, it does not support the claim that prednisolone affects osteoarthritis." +8533593,Prednisolone affects neoplasm,321,"Sixteen reacted to tixocortol pivalate and also to other corticosteroids, particularly to hydrocortisone, which could explain exacerbations of eczema in these cases.",False,"Is the triple 'Prednisolone affects neoplasm' supported by the sentence: 'Sixteen reacted to tixocortol pivalate and also to other corticosteroids, particularly to hydrocortisone, which could explain exacerbations of eczema in these cases.'?","No, the statement does not provide direct or indirect support for the phrase ""Prednisolone affects neoplasm."" The statement discusses patients who reacted to tixocortol pivalate and other corticosteroids such as hydrocortisone, which exacerbated eczema symptoms in these cases. Prednisolone is a corticosteroid like hydrocortisone but it is not explicitly mentioned in the statement as having any effect on neoplasm (abnormal growths such as tumors). + + To further clarify: + + - Neoplasm refers to new and abnormal growths in the body, which can be benign (non-cancerous) or malignant (cancerous). + - Prednisolone is a synthetic glucocorticoid, which is commonly used in treating inflammatory diseases like asthma, rheumatoid arthritis, inflammatory bowel disease, etc., but it has also been used in some cancer treatments due to its immunosuppressive properties. + + However, based on the provided statement alone, there is no mention or evidence implying that prednis" +7800426,Prednisolone affects acute lymphoblastic leukemia,322,"Finally, transient pre-treatment of healthy humans with cortisol induces a bi-phasic response during a later, delayed systemic inflammatory response: an intermediate cortisol concentration augments inflammation while a high cortisol concentration is neither pro- nor anti-inflammatory.",False,"Is the triple 'Prednisolone affects acute lymphoblastic leukemia' supported by the sentence: 'Finally, transient pre-treatment of healthy humans with cortisol induces a bi-phasic response during a later, delayed systemic inflammatory response: an intermediate cortisol concentration augments inflammation while a high cortisol concentration is neither pro- nor anti-inflammatory.'?","No, the statement does not provide direct support for the claim that prednisolone affects acute lymphoblastic leukemia (ALL). The statement discusses cortisol's effect on inflammation in healthy humans, while prednisolone is a synthetic glucocorticoid similar to cortisol but with more potent anti-inflammatory effects. Although both cortisol and prednisolone have implications in treating leukemia due to their anti-inflammatory properties, the provided statement does not establish any connection between prednisolone and ALL specifically. + + + + However, it is important to acknowledge that glucocorticoids like prednisolone have been widely used in treating ALL due to their ability to induce apoptosis in leukemic blasts, suppress inflammation, and inhibit cell proliferation [1]. While the statement does not provide direct evidence for prednisolone affecting ALL, it does contribute to understanding how corticosteroids can influence immune responses in general. + + + + + + [1] Pui, C. H., & Evans, W. E. (" +7395227,Prednisolone affects systemic lupus erythematosus,323,"Adrenaline induces the early posthypoglycaemic insulin resistance, whereas cortisol and growth hormone are important for the insulin resistance that is observed later following hypoglycaemia.",False,"Is the triple 'Prednisolone affects systemic lupus erythematosus' supported by the sentence: 'Adrenaline induces the early posthypoglycaemic insulin resistance, whereas cortisol and growth hormone are important for the insulin resistance that is observed later following hypoglycaemia.'?","No, the statement does not provide direct or indirect support for the phrase ""Prednisolone affects systemic lupus erythematosus"". The statement discusses the effects of adrenaline, cortisol, and growth hormone on insulin resistance following hypoglycaemia, while prednisolone is not mentioned at all in this context. Prednisolone is a synthetic glucocorticoid often used in treating inflammatory diseases such as systemic lupus erythematosus (SLE), but its mechanism of action is distinct from that of adrenaline, cortisol, and growth hormone in relation to insulin resistance in hypoglycaemia. Hence, there is no connection between these two pieces of information that could provide support for the initial phrase about prednisolone affecting SLE." +21722189,Prednisolone affects Prednisone,324,"RESULTS: Within 24 hours following TBI, the concentrations of total cortisol, ACTH and gastrin increased proportionally to the severity of injury, especially significant in the experimental group (P less than 0.05).",False,"Is the triple 'Prednisolone affects Prednisone' supported by the sentence: 'RESULTS: Within 24 hours following TBI, the concentrations of total cortisol, ACTH and gastrin increased proportionally to the severity of injury, especially significant in the experimental group (P less than 0.05).'?","No, the statement does not provide direct or indirect support for the phrase ""Prednisolone affects Prednisone."" The provided result is about increased concentrations of total cortisol, ACTH (adrenocorticotropic hormone), and gastrin following traumatic brain injury (TBI), which is significant in the experimental group. Prednisolone and Prednisone are both corticosteroids used in medical treatments; however, there is no mention of either in the given result, nor any comparison between them that would suggest an effect of one on the other." +9655099,Prednisolone has input Prednisone,325,NEW OR UNIQUE INFORMATION PROVIDED: This case is the first published report of hydrocortisone-responsive hypotension and transient CIRCI associated with naturally occurring septic shock in a dog.,False,Is the triple 'Prednisolone has input Prednisone' supported by the sentence: 'NEW OR UNIQUE INFORMATION PROVIDED: This case is the first published report of hydrocortisone-responsive hypotension and transient CIRCI associated with naturally occurring septic shock in a dog.'?,"No, the phrase ""Prednisolone has input Prednisone"" does not receive indirect support from the statement provided. + + + The statement discusses a case report in dogs where hydrocortisone was used for hypotension and transient Critical Illness-Related Corticosteroid Insufficiency (CIRCI) associated with naturally occurring septic shock. Prednisolone is a synthetic glucocorticoid similar to Prednisone but metabolized differently in dogs. The statement does not provide any information about Prednisolone affecting Prednisone levels in dogs or otherwise. + + + To support ""Prednisolone has input Prednisone,"" one would need evidence showing Prednisolone metabolism leading to Prednisone production in dogs specifically; however, it is generally accepted that Prednisolone is metabolized into inactive compounds in dogs rather than being converted into Prednisone. Therefore, there is no indirect support from the given statement for ""Prednisolone has input Prednisone.""" +27206106,Prednisolone disrupts uveitis,326,Several types of the congenital adrenal hyperplasias are associated with decreased cortisol production and excessive adrenal sex steroid secretion.,False,Is the triple 'Prednisolone disrupts uveitis' supported by the sentence: 'Several types of the congenital adrenal hyperplasias are associated with decreased cortisol production and excessive adrenal sex steroid secretion.'?,"No, the statement does not provide direct or indirect support for the phrase ""Prednisolone disrupts uveitis."" The association between certain types of congenital adrenal hyperplasias (CAH) and decreased cortisol production along with excessive adrenal sex steroid secretion is related to impaired cortisol synthesis due to genetic defects in enzymes involved in steroidogenesis. Prednisolone is a synthetic glucocorticoid used primarily for its potent anti-inflammatory effects in various conditions like uveitis, an inflammation of the uveal tract in the eye. Although both statements discuss corticosteroids (cortisol and prednisolone), they describe different biological processes that do not inherently support the disruption of uveitis by prednisolone." +26515767,Prednisolone disrupts neoplasm,327,[Use of cryo-apheresis in the treatment of patients with cortisol-dependent bronchial asthma].,False,Is the triple 'Prednisolone disrupts neoplasm' supported by the sentence: '[Use of cryo-apheresis in the treatment of patients with cortisol-dependent bronchial asthma].'?,"No, the statement does not provide indirect support for the phrase ""Prednisolone disrupts neoplasm."" The provided statement discusses cryo-apheresis in the treatment of cortisol-dependent bronchial asthma patients, without mentioning Prednisolone or its effects on neoplasms (abnormal growths that can become cancerous). Therefore, it does not offer any evidence or implications regarding Prednisolone's impact on neoplasm disruption. + + + + To further clarify, Prednisolone is a synthetic glucocorticoid often used as an anti-inflammatory drug in various conditions such as asthma, rheumatoid arthritis, and inflammatory bowel disease [1]. Although glucocorticoids have been linked to cancer development in some instances due to their immunosuppressive effects [2], there is no direct information in the statement that would support Prednisolone specifically disrupting neoplasms. + + + + + + + + References: + + + + [1] ""Prednisolone."" MedlinePlus," +26379811,Prednisolone disrupts contact dermatitis,328,Hypotension after recruitment was reduced by HC (0 vs. 30%).,False,Is the triple 'Prednisolone disrupts contact dermatitis' supported by the sentence: 'Hypotension after recruitment was reduced by HC (0 vs. 30%).'?,"No, the statement ""Hypotension after recruitment was reduced by HC (0 vs. 30%)"" does not provide indirect support for the phrase ""Prednisolone disrupts contact dermatitis"". The two statements discuss different aspects of medical interventions - one focuses on hypotension reduction by HC (hydrocortisone) in recruited individuals while the other refers to Prednisolone's impact on contact dermatitis. There is no connection between these two variables in the provided statement that would allow us to infer any supportive relationship between them." +25763558,Prednisolone disrupts pneumonia,329,Fetal plasma cortisol concentrations were increased ( P < 0.05) during all levels of hypoxia.,False,Is the triple 'Prednisolone disrupts pneumonia' supported by the sentence: 'Fetal plasma cortisol concentrations were increased ( P < 0.05) during all levels of hypoxia.'?,"No, the statement does not provide direct or indirect support for the phrase ""Prednisolone disrupts pneumonia."" The finding that fetal plasma cortisol concentrations increase during hypoxia does not necessarily imply a connection to prednisolone or pneumonia. Prednisolone is a synthetic glucocorticoid often used in clinical settings for its anti-inflammatory effects, while pneumonia is an infection causing inflammation in lung tissue. The statement discusses an increase in cortisol levels due to hypoxia in fetal plasma; however, it does not establish a relationship between prednisolone usage and disrupted pneumonia. Further investigation involving prednisolone, pneumonia models, and hypoxia would be required to establish such a connection." +25233555,Prednisolone disrupts allergic disease,330,"INTRA-CELL CORTISOL: Attention is also focused on the potential implication of cortisol in the genesis of metabolic syndrome, because cortisol is a potent antagonist of the effect of insulin and its presence in excess enhances visceral obesity and insulin resistance.",False,"Is the triple 'Prednisolone disrupts allergic disease' supported by the sentence: 'INTRA-CELL CORTISOL: Attention is also focused on the potential implication of cortisol in the genesis of metabolic syndrome, because cortisol is a potent antagonist of the effect of insulin and its presence in excess enhances visceral obesity and insulin resistance.'?","No, the statement does not provide direct or indirect support for the phrase ""Prednisolone disrupts allergic disease."" The provided statement discusses cortisol's potential implications in metabolic syndrome, focusing on its antagonistic effect on insulin and its contribution to visceral obesity and insulin resistance. Prednisolone is a synthetic glucocorticoid often prescribed for its potent anti-inflammatory properties; however, it is not explicitly linked to allergic disease disruption in either statement nor in any known allopathic medical contexts. + + To provide indirect support for ""Prednisolone disrupts allergic disease,"" there would need to be some connection between prednisolone, cortisol (as glucocorticoids share many properties), and allergic disease pathophysiology. Although prednisolone can modulate immune responses related to allergic disease (such as reducing eosinophil numbers), the statement in question does not provide sufficient evidence for such an assertion. + + Moreover, it is essential to consider that allergic disease is complex in nature and involves various cellular components (e.g., mast cells, basophils" +14331279,Prednisolone disrupts hypereosinophilic syndrome,331,The effect of hydrocortisone on standardized skin-surface trauma.,False,Is the triple 'Prednisolone disrupts hypereosinophilic syndrome' supported by the sentence: 'The effect of hydrocortisone on standardized skin-surface trauma.'?,"No, the statement ""The effect of hydrocortisone on standardized skin-surface trauma"" does not provide indirect support for the phrase ""Prednisolone disrupts hypereosinophilic syndrome."" + + Hydrocortisone and Prednisolone are both corticosteroids, but they have different chemical structures and pharmacological properties. Hydrocortisone is primarily used for its anti-inflammatory effects in treating conditions like skin trauma, while Prednisolone is often used in managing disorders associated with excessive immune response like hypereosinophilic syndrome due to its stronger immunosuppressive properties. + + The study referenced in the statement focuses on hydrocortisone's effect on skin-surface trauma, which is an entirely different physiological context than hypereosinophilic syndrome. Therefore, even though both drugs belong to the same class (corticosteroids), we cannot infer that one disrupts hypereosinophilic syndrome based on the other's effect on skin trauma. + + To establish whether prednisolone disrupts hypereosinophilic syndrome, direct evidence from" +10594561,Prednisolone disrupts asthma,332,The action of hydrocortisone in synovial inflammation.,False,Is the triple 'Prednisolone disrupts asthma' supported by the sentence: 'The action of hydrocortisone in synovial inflammation.'?,"No, the statement ""The action of hydrocortisone in synovial inflammation"" does not provide indirect support for the phrase ""Prednisolone disrupts asthma."" Hydrocortisone and Prednisolone are both corticosteroids used in treating inflammation; however, they act on different cells and tissues in the body. Hydrocortisone is primarily used for treating inflammation in joints (synovial inflammation), whereas Prednisolone is often used for treating asthma due to its action on lung tissue. + + Although both drugs have anti-inflammatory properties, their specific effects on different cells and tissues limit the transferability of evidence from one drug to another. Therefore, it is essential to rely on studies that investigate Prednisolone's effects on asthma when assessing its potential benefits for treating that particular condition." +8854473,Prednisolone disrupts Inflammation,333,"The effects of stressful life events, coping, and cortisol on HIV infection.",False,"Is the triple 'Prednisolone disrupts Inflammation' supported by the sentence: 'The effects of stressful life events, coping, and cortisol on HIV infection.'?","No, the statement ""The effects of stressful life events, coping, and cortisol on HIV infection"" does not provide direct or indirect support for the phrase ""Prednisolone disrupts Inflammation."" + + Prednisolone is a synthetic glucocorticoid, which is a class of steroid hormones that includes cortisol. Glucocorticoids like prednisolone have anti-inflammatory effects by suppressing the immune system. However, the statement provided discusses stressful life events, coping mechanisms, and cortisol in relation to HIV infection, but it does not mention prednisolone nor inflammation disruption explicitly or implicitly. + + The connection between stressful life events, coping mechanisms, cortisol (a natural glucocorticoid), and HIV infection is complex. Increased cortisol levels due to stress can negatively impact immune function, potentially increasing susceptibility to HIV infection and disease progression. Coping mechanisms may mediate some of these effects by modulating cortisol levels and stress responses. However, these phenomena do not necessarily imply that prednisolone disrupts inflammation in" +27646185,Prednisolone prevents allergic disease,334,"Immunologic and hemodynamic effects of ""low-dose"" hydrocortisone in septic shock: a double-blind, randomized, placebo-controlled, crossover study.",False,"Is the triple 'Prednisolone prevents allergic disease' supported by the sentence: 'Immunologic and hemodynamic effects of ""low-dose"" hydrocortisone in septic shock: a double-blind, randomized, placebo-controlled, crossover study.'?","No, the statement does not provide indirect support for the phrase ""Prednisolone prevents allergic disease."" The study mentioned is about immunologic and hemodynamic effects of ""low-dose"" hydrocortisone in septic shock, which is different from Prednisolone and allergic disease. Prednisolone is a synthetic glucocorticoid used mainly for its anti-inflammatory effects while allergic disease is typically managed through antihistamines, decongestants, or immunotherapy. Although both Prednisolone and hydrocortisone belong to the glucocorticoid class, they have different therapeutic applications, and their effects on allergic diseases may not be generalized from one drug to another." +26227245,Prednisolone prevents synovitis,335,"To prolong the anti-tumor effect some mice were also given cyclophosphamide, hydrocortisone, or a second injection of virus.",False,"Is the triple 'Prednisolone prevents synovitis' supported by the sentence: 'To prolong the anti-tumor effect some mice were also given cyclophosphamide, hydrocortisone, or a second injection of virus.'?","No, the phrase ""Prednisolone prevents synovitis"" does not receive at least indirect support from the statement provided. The statement discusses an experiment involving mice that were given cyclophosphamide, hydrocortisone, or a second injection of virus in order to prolong the anti-tumor effect. However, prednisolone is not mentioned in this statement. In order for there to be indirect support for prednisolone preventing synovitis, there should be some connection made between prednisolone and either synovitis or another treatment for synovitis in the statement. Since no such connection is made in the statement provided, it does not offer indirect support for prednisolone preventing synovitis." +19453072,Prednisolone prevents hypereosinophilic syndrome,336,"In conclusion, HRT in postmenopausal asthmatic women has a favorable influence on the course of asthma, reduces daily use of glucocorticosteroids and frequency of asthma exacerbations and normalizes serum concentrations of estradiol, cortisol and DHEAS, which were decreased before HRT.",False,"Is the triple 'Prednisolone prevents hypereosinophilic syndrome' supported by the sentence: 'In conclusion, HRT in postmenopausal asthmatic women has a favorable influence on the course of asthma, reduces daily use of glucocorticosteroids and frequency of asthma exacerbations and normalizes serum concentrations of estradiol, cortisol and DHEAS, which were decreased before HRT.'?","No, the statement does not provide direct or indirect support for the claim that Prednisolone prevents hypereosinophilic syndrome. The statement discusses hormone replacement therapy (HRT) in postmenopausal asthmatic women and its effects on asthma course, glucocorticosteroid use, asthma exacerbations, and serum concentrations of estradiol, cortisol, and DHEAS. There is no mention of Prednisolone or hypereosinophilic syndrome in the statement. Therefore, it does not support the claim that Prednisolone prevents hypereosinophilic syndrome." +16706850,Prednisolone prevents neoplasm,337,"However, after adjusting for the effect of obesity by multiple regression, higher plasma cortisol was independently associated with higher diastolic blood pressure in men (r = 0.21, P = 0.04) but not in women, and higher fasting serum triglyceride levels in women (r = 0.28, P < 0. 001) but not in men.",False,"Is the triple 'Prednisolone prevents neoplasm' supported by the sentence: 'However, after adjusting for the effect of obesity by multiple regression, higher plasma cortisol was independently associated with higher diastolic blood pressure in men (r = 0.21, P = 0.04) but not in women, and higher fasting serum triglyceride levels in women (r = 0.28, P < 0. 001) but not in men.'?","No, the statement does not provide indirect support for the phrase ""Prednisolone prevents neoplasm."" The statement discusses the association between higher plasma cortisol levels and increased diastolic blood pressure in men as well as elevated fasting serum triglyceride levels in women. Prednisolone is a synthetic glucocorticoid used in treating various conditions such as inflammation; however, there is no mention or implication in the statement regarding its potential preventive effects on neoplasm (tumor formation). Therefore, it is inappropriate to infer any connection between Prednisolone and neoplasm prevention based on this statement alone." +15809068,Prednisolone prevents colitis,338,"ii) Reduction of cortisone to cortisol in the liver may increase insulin resistance in type 2 diabetes mellitus, and inhibition of the enzyme may lead to a decrease in gluconeogenesis.",False,"Is the triple 'Prednisolone prevents colitis' supported by the sentence: 'ii) Reduction of cortisone to cortisol in the liver may increase insulin resistance in type 2 diabetes mellitus, and inhibition of the enzyme may lead to a decrease in gluconeogenesis.'?","No, the statement does not provide indirect support for the phrase ""Prednisolone prevents colitis."" The provided information discusses how reducing cortisone to cortisol in the liver can impact insulin resistance in type 2 diabetes mellitus and inhibition of enzymes leading to decreased gluconeogenesis. Prednisolone is a synthetic glucocorticoid that acts on glucocorticoid receptors in various cells throughout the body; its primary mechanism is not related to preventing colitis. Although glucocorticoids like prednisolone can have anti-inflammatory effects that may potentially affect colitis symptoms in some contexts, the given statement does not provide any information that would suggest prednisolone prevents colitis." +11858005,Prednisolone prevents asthma,339,"Pretreatment of rats with hydrocortisone or protamin-Zn-insulin within 4 days altered in subsequent acute hypoxia (3 hrs, ""height"" 10 000 m) the isoenzyme spectrum of LDH in lungs, liver tissue and kidney cortex.",False,"Is the triple 'Prednisolone prevents asthma' supported by the sentence: 'Pretreatment of rats with hydrocortisone or protamin-Zn-insulin within 4 days altered in subsequent acute hypoxia (3 hrs, ""height"" 10 000 m) the isoenzyme spectrum of LDH in lungs, liver tissue and kidney cortex.'?","No, the statement does not provide indirect support for the phrase ""Prednisolone prevents asthma."" The statement discusses the effects of pretreatment with hydrocortisone or protamin-Zn-insulin on rats subjected to acute hypoxia. Prednisolone is neither mentioned nor implied in this statement. Furthermore, while hydrocortisone is a glucocorticoid like prednisolone, it is not the same compound, and their effects on asthma may not be identical. Additionally, changes in isoenzyme spectrums do not necessarily translate to prevention of asthma. Therefore, there is no clear connection between these two pieces of information." +10983909,Prednisolone prevents leprosy,340,Previously we related persistent cortisol increases to memory impairments in elderly humans studied over five years.,False,Is the triple 'Prednisolone prevents leprosy' supported by the sentence: 'Previously we related persistent cortisol increases to memory impairments in elderly humans studied over five years.'?,"No, the statement does not provide indirect support for the phrase ""Prednisolone prevents leprosy."" The initial statement discusses cortisol increases being related to memory impairments in elderly humans over five years. Prednisolone is a synthetic glucocorticoid used for its anti-inflammatory effects; it is not directly related to leprosy prevention. The connection between cortisol (a hormone naturally produced in the human body) and memory impairment does not imply that Prednisolone can prevent leprosy. + + However, it is worth noting that glucocorticoids like Prednisolone have been explored in leprosy treatment due to their anti-inflammatory properties. But simply because cortisol has some connection to memory impairments does not imply that Prednisolone prevents leprosy. The two statements operate in different contexts (memory impairment vs leprosy prevention) and involve different substances (cortisol vs Prednisolone). + + To establish indirect support for Prednisolone preventing leprosy based on these statements, there would need to be an explicit link between cortisol increases and leprosy" +10240036,Prednisolone prevents Inflammation,341,It was suggested that the progressive shift from type 1 to type 2 cytokine production characteristic of HIV infection could be at least partially provoked by the increase in the production of cortisol and the reduction of DHEA.,True,Is the triple 'Prednisolone prevents Inflammation' supported by the sentence: 'It was suggested that the progressive shift from type 1 to type 2 cytokine production characteristic of HIV infection could be at least partially provoked by the increase in the production of cortisol and the reduction of DHEA.'?,"Yes, there is indirect support for the phrase ""Prednisolone prevents Inflammation"" from the statement provided. + + + Prednisolone is a synthetic glucocorticoid hormone that acts as an anti-inflammatory and immunosuppressive agent. Glucocorticoids like Prednisolone work by binding to glucocorticoid receptors in cells throughout the body, inhibiting the production of pro-inflammatory cytokines like type 1 cytokines (e.g., interferon-gamma) while promoting the production of anti-inflammatory cytokines like type 2 cytokines (e.g., interleukin-4). + + + The statement suggests that during HIV infection, there is an increase in cortisol production and a reduction in DHEA levels, which could lead to a shift from type 1 to type 2 cytokine production. Cortisol is another glucocorticoid hormone that shares some functional similarities with Prednisolone; however, it is naturally produced in the body and has more physi" +18452194,Prednisolone exacerbates ulcerative colitis,342,CONCLUSIONS: This study suggests that 24 h urinary free cortisol could be considered as a potential index of adrenal cortisol production in patients with liver cirrhosis and it potentially detects patients with a high mortality risk.,False,Is the triple 'Prednisolone exacerbates ulcerative colitis' supported by the sentence: 'CONCLUSIONS: This study suggests that 24 h urinary free cortisol could be considered as a potential index of adrenal cortisol production in patients with liver cirrhosis and it potentially detects patients with a high mortality risk.'?,"No, the statement does not provide indirect support for the phrase ""Prednisolone exacerbates ulcerative colitis."" The conclusion in the statement is about using 24-hour urinary free cortisol as an index for adrenal cortisol production in patients with liver cirrhosis and its potential association with mortality risk. It does not mention prednisolone or ulcerative colitis. Prednisolone is a synthetic glucocorticoid used primarily for its anti-inflammatory properties in various conditions such as asthma, rheumatoid arthritis, and inflammatory bowel diseases like ulcerative colitis; however, its specific impact on ulcerative colitis exacerbation would need separate evidence for evaluation." +25753407,Prednisolone predisposes neoplasm,343,Congenital adrenal hyperplasia (CAH) is an autosomal recessive disorder that leads to the partial or complete deficiency of cortisol and aldosterone production from the adrenal glands.,False,Is the triple 'Prednisolone predisposes neoplasm' supported by the sentence: 'Congenital adrenal hyperplasia (CAH) is an autosomal recessive disorder that leads to the partial or complete deficiency of cortisol and aldosterone production from the adrenal glands.'?,"No, the statement ""Congenital adrenal hyperplasia (CAH) is an autosomal recessive disorder that leads to the partial or complete deficiency of cortisol and aldosterone production from the adrenal glands"" does not provide indirect support for the phrase ""Prednisolone predisposes neoplasm."" + + Prednisolone is a synthetic glucocorticoid hormone used in various medical treatments, including for inflammatory conditions and as a replacement therapy in adrenal insufficiency disorders like CAH. While it is true that people with CAH may be prescribed Prednisolone, there is no direct link established between Prednisolone use and an increased predisposition to neoplasm (abnormal tissue growth that can lead to cancer) based on the information provided. + + The development of neoplasms is influenced by various factors such as genetics, environment, lifestyle, and other medical conditions. While some studies suggest that prolonged glucocorticoid use might be associated with an increased risk for certain types of cancer, it is crucial to differentiate between correlation and causation in such cases." +16546227,Prednisolone predisposes pneumonia,344,[Reaction of autogenous cortisol production in patients with extensive psoriasis vulgaris or atopic dermatitis following external administration of a 0.25% prednicarbate salve (W/O emulsion)].,False,Is the triple 'Prednisolone predisposes pneumonia' supported by the sentence: '[Reaction of autogenous cortisol production in patients with extensive psoriasis vulgaris or atopic dermatitis following external administration of a 0.25% prednicarbate salve (W/O emulsion)].'?,"No, the statement does not provide indirect support for the phrase ""Prednisolone predisposes pneumonia."" The statement discusses the reaction of autogenous cortisol production in patients with extensive psoriasis vulgaris or atopic dermatitis following external administration of a 0.25% prednicarbate salve (W/O emulsion). Prednisolone is not mentioned in this statement; therefore, it cannot provide any evidence for or against its potential to predispose pneumonia. Prednisolone is a synthetic glucocorticoid often used in treating various inflammatory diseases; however, its potential link to pneumonia would require separate investigation and evidence." +27027571,Hydrocortisone related to HIV infectious disease,345,"OBJECTIVE: Corticosteroid-binding globulin (CBG), the cortisol transport protein, is cleaved from high-affinity (haCBG) to low-affinity (laCBG) CBG at sites of inflammation releasing bioavailable, anti-inflammatory cortisol.",False,"Is the triple 'Hydrocortisone related to HIV infectious disease' supported by the sentence: 'OBJECTIVE: Corticosteroid-binding globulin (CBG), the cortisol transport protein, is cleaved from high-affinity (haCBG) to low-affinity (laCBG) CBG at sites of inflammation releasing bioavailable, anti-inflammatory cortisol.'?","No, the statement does not provide direct or indirect support for the phrase ""Hydrocortisone related to HIV infectious disease."" The statement discusses corticosteroid-binding globulin (CBG) and its role in releasing bioavailable cortisol at sites of inflammation; however, it does not mention hydrocortisone nor HIV infectious disease. Hydrocortisone is a type of corticosteroid that can bind to CBG; therefore, understanding CBG behavior might have implications for hydrocortisone usage in certain contexts. However, without explicit reference to hydrocortisone or HIV in the statement, there is no specific support for that phrase." +25927636,Hydrocortisone related to cardiac arrest,346,The propensity to develop type 1 diabetes or type 2 diabetes/metabolic syndrome depends on the propensity to release of cortisol which correlates with race.,False,Is the triple 'Hydrocortisone related to cardiac arrest' supported by the sentence: 'The propensity to develop type 1 diabetes or type 2 diabetes/metabolic syndrome depends on the propensity to release of cortisol which correlates with race.'?,"No, the statement does not provide indirect support for the phrase ""Hydrocortisone related to cardiac arrest."" The initial statement discusses how race may influence the propensity for releasing cortisol, which in turn affects the likelihood of developing certain types of diabetes or metabolic syndrome. Hydrocortisone is synthetic cortisol; however, there is no direct link established between cortisol release influenced by race and cardiac arrest in either statement. While it is true that high levels of cortisol can contribute to various health issues such as diabetes, hypertension, and osteoporosis, it does not automatically imply that hydrocortisone usage would be associated with cardiac arrest. Further investigation is required to establish such a link conclusively." +25797574,Hydrocortisone related to lymphoma,347,"CIRCI is characterized by an inadequate production of cortisol in relation to an increased demand during periods of severe stress, particularly in critical illnesses such as sepsis or septic shock.",False,"Is the triple 'Hydrocortisone related to lymphoma' supported by the sentence: 'CIRCI is characterized by an inadequate production of cortisol in relation to an increased demand during periods of severe stress, particularly in critical illnesses such as sepsis or septic shock.'?","No, the statement does not provide direct or indirect support for the phrase ""Hydrocortisone related to lymphoma."" The statement discusses CIRCI (Critical Illness-Related Corticosteroid Insufficiency), which is characterized by inadequate cortisol production in response to severe stress in conditions like sepsis or septic shock. Hydrocortisone is a synthetic glucocorticoid often used as replacement therapy in CIRCI patients. Although lymphoma is a type of cancer that can be associated with immune system dysfunction, no link is established between hydrocortisone use in CIRCI patients and lymphoma in the given statement." +25131277,Hydrocortisone related to Crohn disease,348,Synacthen test diagnosed Addison's disease with a clear deficiency of cortisol production.,False,Is the triple 'Hydrocortisone related to Crohn disease' supported by the sentence: 'Synacthen test diagnosed Addison's disease with a clear deficiency of cortisol production.'?,"No, the statement ""Synacthen test diagnosed Addison's disease with a clear deficiency of cortisol production"" does not provide indirect support for the phrase ""Hydrocortisone related to Crohn disease"". + + The Synacthen test is used to diagnose conditions related to cortisol deficiency, such as Addison's disease. Hydrocortisone is a synthetic form of cortisol, a hormone that the body naturally produces in response to stress. It is commonly used to treat conditions associated with cortisol deficiency, such as Addison's disease. + + However, Crohn's disease is an inflammatory bowel disease that is not primarily characterized by cortisol deficiency. While corticosteroids like hydrocortisone can be used to manage inflammation in Crohn's disease, this does not imply a direct relationship between hydrocortisone and Crohn's disease. The statement about the Synacthen test diagnosing Addison's disease does not provide any information about hydrocortisone use in Crohn's disease, therefore it does not offer indirect support for the stated phrase." +19793698,Hydrocortisone related to alcohol abuse,349,"Enhanced cortisol production rates, free cortisol, and 11beta-HSD-1 expression correlate with visceral fat and insulin resistance in men: effect of weight loss.",False,"Is the triple 'Hydrocortisone related to alcohol abuse' supported by the sentence: 'Enhanced cortisol production rates, free cortisol, and 11beta-HSD-1 expression correlate with visceral fat and insulin resistance in men: effect of weight loss.'?","No, the statement does not provide direct or indirect support for the phrase ""Hydrocortisone related to alcohol abuse."" The statement discusses cortisol production rates, free cortisol, and 11beta-HSD-1 expression in relation to visceral fat and insulin resistance in men, and how these factors change in response to weight loss. Hydrocortisone is a synthetic glucocorticoid often used as a medication and is not mentioned in the statement. Additionally, alcohol abuse is not mentioned in the statement either. Therefore, there is no connection that can be drawn between hydrocortisone and alcohol abuse from this statement." +19531872,Hydrocortisone related to atrial fibrillation,350,"Obesity is also related to dysregulation of cortisol production by the pre-receptor enzyme, 11beta-hydroxysteroid dehydrogenase, and we speculate that this may have a role in the pathogenesis of obesity and raised ICP seen in IIH.",False,"Is the triple 'Hydrocortisone related to atrial fibrillation' supported by the sentence: 'Obesity is also related to dysregulation of cortisol production by the pre-receptor enzyme, 11beta-hydroxysteroid dehydrogenase, and we speculate that this may have a role in the pathogenesis of obesity and raised ICP seen in IIH.'?","No, the statement does not provide direct or indirect support for the phrase ""Hydrocortisone related to atrial fibrillation."" The statement discusses obesity being related to dysregulation of cortisol production by the enzyme 11beta-hydroxysteroid dehydrogenase, which may contribute to pathogenesis in obesity and idiopathic intracranial hypertension (IIH). Hydrocortisone is a synthetic form of cortisol; however, there is no mention in the statement linking cortisol dysregulation specifically to hydrocortisone use or atrial fibrillation. + + The nuances here involve understanding that cortisol is a steroid hormone produced by the adrenal gland in response to stress, while hydrocortisone is a medication used in various medical contexts. The statement focuses on obesity-related cortisol dysregulation in IIH pathogenesis but does not provide any evidence connecting hydrocortisone use to atrial fibrillation risk. + + In conclusion, while cortisol dysregulation may have various implications in human" +18705900,Hydrocortisone related to phobic disorder,351,"This is an extremely rare case of bilateral adrenal tumors, in which the left adrenocortical tumor produced and secreted cortisol or both cortisol and aldosterone and the right one produced and secreted both aldosterone and cortisol, as confirmed by clinical findings and pathological studies using immunohistochemical analysis.",False,"Is the triple 'Hydrocortisone related to phobic disorder' supported by the sentence: 'This is an extremely rare case of bilateral adrenal tumors, in which the left adrenocortical tumor produced and secreted cortisol or both cortisol and aldosterone and the right one produced and secreted both aldosterone and cortisol, as confirmed by clinical findings and pathological studies using immunohistochemical analysis.'?","No, the statement does not provide direct or indirect support for the phrase ""Hydrocortisone related to phobic disorder"". The statement discusses an extremely rare case of bilateral adrenal tumors that produce and secrete cortisol and aldosterone; however, it does not mention anything about hydrocortisone being related to phobic disorder. Hydrocortisone is a synthetic version of cortisol, which is produced naturally in the body by the adrenal glands; therefore, it is not necessarily related to phobic disorders unless explicitly stated in further evidence." +15155784,Hydrocortisone related to psoriasis,352,"We conclude that the clinical picture of late-onset adrenal insufficiency in preterm infants is not a result of an absolute deficiency of cortisol production, but may be a result of a limited ability to synthesize sufficient cortisol for the degree of clinical stress.",False,"Is the triple 'Hydrocortisone related to psoriasis' supported by the sentence: 'We conclude that the clinical picture of late-onset adrenal insufficiency in preterm infants is not a result of an absolute deficiency of cortisol production, but may be a result of a limited ability to synthesize sufficient cortisol for the degree of clinical stress.'?","No, the statement does not provide indirect support for the phrase ""Hydrocortisone related to psoriasis"". The statement discusses late-onset adrenal insufficiency in preterm infants and its potential connection to cortisol production. Hydrocortisone is a synthetic form of cortisol, but the connection between hydrocortisone and psoriasis is unrelated to adrenal insufficiency in preterm infants. Psoriasis is an immune-mediated skin condition that has been treated with hydrocortisone, but the statement does not provide any evidence or reasoning that would link hydrocortisone use to psoriasis treatment." +14891361,"Hydrocortisone related to dermatitis, atopic",353,"Ironically, despite our understanding of the various stressors that promote chronic adult-onset asthma, most of which are known to elevate cortisol production via the hypothalamic-pituitary-adrenal (HPA) axis, inhaled and systemic corticosteroids are the mainstay for the treatment of chronic asthma.",False,"Is the triple 'Hydrocortisone related to dermatitis, atopic' supported by the sentence: 'Ironically, despite our understanding of the various stressors that promote chronic adult-onset asthma, most of which are known to elevate cortisol production via the hypothalamic-pituitary-adrenal (HPA) axis, inhaled and systemic corticosteroids are the mainstay for the treatment of chronic asthma.'?","No, the statement does not provide indirect support for the phrase ""Hydrocortisone related to dermatitis, atopic."" The statement discusses the use of corticosteroids in treating chronic asthma, but it does not mention hydrocortisone specifically, nor does it link corticosteroids to dermatitis or atopic dermatitis. Hydrocortisone is a type of corticosteroid often used in treating various skin conditions such as dermatitis; however, this connection is not made in the provided statement. Therefore, without additional context or evidence linking hydrocortisone to atopic dermatitis, one cannot infer support for that phrase based on the statement alone." +14483328,Hydrocortisone related to bronchopulmonary dysplasia,354,Glucocorticoid insufficiency is common during sepsis and may result from insufficient production of cortisol or peripheral tissues resistance.,False,Is the triple 'Hydrocortisone related to bronchopulmonary dysplasia' supported by the sentence: 'Glucocorticoid insufficiency is common during sepsis and may result from insufficient production of cortisol or peripheral tissues resistance.'?,"No, the statement does not provide direct or indirect support for the phrase ""Hydrocortisone related to bronchopulmonary dysplasia."" The statement discusses glucocorticoid insufficiency during sepsis, which can be due to inadequate cortisol production or peripheral tissue resistance. Hydrocortisone is a type of glucocorticoid often used as a replacement therapy in cases of insufficiency; however, the statement does not establish any connection between glucocorticoid insufficiency (or its related treatments) and bronchopulmonary dysplasia. Bronchopulmonary dysplasia is a chronic lung disease in premature infants, and while glucocorticoids like hydrocortisone have been studied in its treatment, that relationship is not implied in the given statement." +14450267,Hydrocortisone related to adrenal cortex neoplasm,355,"This likely represents an adaptive response to LTH, to prevent excessive cortisol production that would restrict fetal growth and potentially induce preterm delivery.",False,"Is the triple 'Hydrocortisone related to adrenal cortex neoplasm' supported by the sentence: 'This likely represents an adaptive response to LTH, to prevent excessive cortisol production that would restrict fetal growth and potentially induce preterm delivery.'?","No, the statement does not provide indirect support for the phrase ""Hydrocortisone related to adrenal cortex neoplasm"". The provided statement discusses an adaptive response related to cortisol production in relation to long-term hypoxia (LTH), which is unrelated to hydrocortisone or adrenal cortex neoplasm (a type of tumor). Hydrocortisone is a synthetic form of cortisol, a hormone produced by the adrenal gland, but there is no connection made between these elements in either statement." +14387016,Hydrocortisone related to cirrhosis of liver,356,"The reduction in local cortisol production which diminishes the endogenous anti-inflammatory effects, also allows for the progression of both vascular and pulmonary inflammation.",False,"Is the triple 'Hydrocortisone related to cirrhosis of liver' supported by the sentence: 'The reduction in local cortisol production which diminishes the endogenous anti-inflammatory effects, also allows for the progression of both vascular and pulmonary inflammation.'?","No, the statement does not provide direct or indirect support for the phrase ""Hydrocortisone related to cirrhosis of liver."" The provided statement discusses the relationship between cortisol production and inflammation but does not mention hydrocortisone or cirrhosis of the liver. Hydrocortisone is a synthetic version of cortisol, but no connection is made in this statement between hydrocortisone and liver cirrhosis. To establish support for such a claim, additional evidence would be needed that links hydrocortisone use specifically to liver cirrhosis progression." +14360687,Hydrocortisone related to dermatitis,357,"CONCLUSIONS: Patients with newly diagnosed, untreated PC yielded significantly higher cortisol and lower estradiol serum concentrations than controls.",False,"Is the triple 'Hydrocortisone related to dermatitis' supported by the sentence: 'CONCLUSIONS: Patients with newly diagnosed, untreated PC yielded significantly higher cortisol and lower estradiol serum concentrations than controls.'?","No, the statement does not provide direct or indirect support for the phrase ""Hydrocortisone related to dermatitis."" The conclusion in the statement refers to cortisol serum concentrations in patients with prostate cancer (PC) compared to controls, but it does not mention hydrocortisone or dermatitis. Hydrocortisone is a synthetic glucocorticoid hormone used primarily for its anti-inflammatory effects in various conditions such as dermatitis; however, no such connection is made in the provided statement." +13844584,Hydrocortisone related to acute myeloid leukemia,358,"The tumour secreted excessive cortisol and dehydroepiandrosterone-sulphate (DHEA-S), and had invaded the right hepatic lobe and vena cava.",False,"Is the triple 'Hydrocortisone related to acute myeloid leukemia' supported by the sentence: 'The tumour secreted excessive cortisol and dehydroepiandrosterone-sulphate (DHEA-S), and had invaded the right hepatic lobe and vena cava.'?","No, the statement does not provide direct or indirect support for the phrase ""Hydrocortisone related to acute myeloid leukemia"". + + The statement discusses a tumour that secretes excessive cortisol and DHEA-S, and has invaded certain liver structures. Hydrocortisone is a synthetic form of cortisol, a hormone that the body naturally produces in response to stress. DHEA-S is a hormone synthesized from DHEA (dehydroepiandrosterone), which is produced from cholesterol by the adrenal glands; it functions as a precursor to other hormones like testosterone and estrogen. + + Although cortisol and DHEA-S are related to hydrocortisone in terms of their physiological roles and synthesis pathways, no evidence is presented in the statement that connects hydrocortisone specifically to acute myeloid leukemia (AML). AML is a type of cancer that affects the bone marrow's production of blood cells; it is not necessarily linked to cortisol or hydrocortisone levels in" +13213365,Hydrocortisone related to chronic primary adrenal insufficiency,359,Replacement doses of hydrocortisone were administered throughout treatment to counteract potential adrenal insufficiency secondary to the ketoconazole.,True,Is the triple 'Hydrocortisone related to chronic primary adrenal insufficiency' supported by the sentence: 'Replacement doses of hydrocortisone were administered throughout treatment to counteract potential adrenal insufficiency secondary to the ketoconazole.'?,"Yes, indirect support can be inferred from the statement provided. The use of hydrocortisone in treating potential adrenal insufficiency secondary to ketoconazole does suggest a relationship between hydrocortisone and adrenal insufficiency. However, it does not specifically mention chronic primary adrenal insufficiency. + + The statement indicates that hydrocortisone was used as a replacement therapy to counteract adrenal insufficiency that was secondary to ketoconazole treatment. This implies that hydrocortisone has a role in managing adrenal insufficiency, which is a characteristic feature of chronic primary adrenal insufficiency. Therefore, while the statement does not explicitly mention chronic primary adrenal insufficiency, it does provide indirect support for the association between hydrocortisone and adrenal insufficiency. + + It is important to note that adrenal insufficiency can be secondary to various causes, including diseases or medications like ketoconazole that affect adrenal function. Chronic primary adrenal insufficiency, on the other hand, is caused by intrinsic dysfunction or damage to the adrenal glands" +12756660,Hydrocortisone related to borderline personality disorder,360,Amplication by hydrocortisone of the induction of cytotoxic response in vitro to syngeneic murine leukemias.,False,Is the triple 'Hydrocortisone related to borderline personality disorder' supported by the sentence: 'Amplication by hydrocortisone of the induction of cytotoxic response in vitro to syngeneic murine leukemias.'?,"No, the statement ""Amplication by hydrocortisone of the induction of cytotoxic response in vitro to syngeneic murine leukemias"" does not provide indirect support for the phrase ""Hydrocortisone related to borderline personality disorder."" + + The statement discusses hydrocortisone's role in amplifying cytotoxic responses in vitro (in a lab setting) to syngeneic murine leukemias (mouse leukemias). This is a far cry from making any connection between hydrocortisone and borderline personality disorder (BPD), which is a complex mental health condition affecting human behavior and emotion regulation. + + Although hydrocortisone is a hormone that can influence various physiological processes in humans (including mood regulation), there is no direct link established between hydrocortisone and BPD in this statement. To support such a claim, one would need evidence from studies involving human subjects diagnosed with BPD, assessing hydrocortisone levels, response to hydrocortisone treatment, or other relevant factors. + + Therefore, it is crucial to remain cautious when interpre" +12576998,Hydrocortisone related to Hypoxemia,361,The results demonstrated that the intrarectal dose of indomethacin and hydrocortisone inhibited the development of tumors from microscopic carcinoma lesions in the large bowel and growing further.,False,Is the triple 'Hydrocortisone related to Hypoxemia' supported by the sentence: 'The results demonstrated that the intrarectal dose of indomethacin and hydrocortisone inhibited the development of tumors from microscopic carcinoma lesions in the large bowel and growing further.'?,"No, the statement does not provide indirect support for the phrase ""Hydrocortisone related to Hypoxemia"". The statement discusses the effects of intrarectal doses of indomethacin and hydrocortisone on tumor development in the large bowel, but it does not mention or imply anything about hypoxemia, which is a condition characterized by low levels of oxygen in the blood. Hypoxemia is not even remotely related to tumor development or inhibition in this context. Therefore, without further information linking hydrocortisone to hypoxemia specifically, there is no basis for such a claim." +11888652,Hydrocortisone related to congenital adrenal hyperplasia,362,"Growth of ovarian, lung, breast, and kidney carcinomas was increased by 136%, 126%, 78% and 69%, respectively, whereas melanomas, sarcomas, and colon tumors were inhibited by hydrocortisone.",False,"Is the triple 'Hydrocortisone related to congenital adrenal hyperplasia' supported by the sentence: 'Growth of ovarian, lung, breast, and kidney carcinomas was increased by 136%, 126%, 78% and 69%, respectively, whereas melanomas, sarcomas, and colon tumors were inhibited by hydrocortisone.'?","No, the statement does not provide indirect support for the phrase ""Hydrocortisone related to congenital adrenal hyperplasia."" The statement discusses the effects of hydrocortisone on various types of carcinomas and tumors but does not mention congenital adrenal hyperplasia (CAH). CAH is a genetic disorder resulting from mutations in genes encoding enzymes necessary for cortisol biosynthesis in the adrenal glands; it is not caused by exposure to hydrocortisone. Therefore, while hydrocortisone may have an impact on carcinomas and tumors as stated in the given claim, it does not imply any connection between hydrocortisone and CAH." +11866289,Hydrocortisone related to nicotine dependence,363,Insufficient cortisol limits the ability of the sick newborn to handle stress and inhibit pulmonary inflammation.,False,Is the triple 'Hydrocortisone related to nicotine dependence' supported by the sentence: 'Insufficient cortisol limits the ability of the sick newborn to handle stress and inhibit pulmonary inflammation.'?,"No, the statement does not provide indirect support for the phrase ""Hydrocortisone related to nicotine dependence"". + + + + The statement discusses the role of cortisol, a hormone that the body produces in response to stress, in newborns. It suggests that insufficient cortisol levels can impact a newborn's ability to manage stress and inhibit pulmonary inflammation. + + + + Hydrocortisone is a synthetic form of cortisol often used in medical treatments. While it is true that hydrocortisone can help manage stress and inflammation, there is no mention of nicotine or nicotine dependence in the statement. Nicotine dependence is a complex condition involving both psychological and physiological factors, which is not addressed in the statement. Therefore, it does not provide indirect support for the phrase ""Hydrocortisone related to nicotine dependence""." +11530989,Hydrocortisone related to pneumonia,364,"BACKGROUND: Hepatic 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) activity, which converts cortisone (inactive) to cortisol, is downregulated in obesity.",False,"Is the triple 'Hydrocortisone related to pneumonia' supported by the sentence: 'BACKGROUND: Hepatic 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) activity, which converts cortisone (inactive) to cortisol, is downregulated in obesity.'?","No, the statement does not provide direct or indirect support for the phrase ""Hydrocortisone related to pneumonia."" The background statement discusses hepatic 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) activity, its role in converting cortisone (inactive) to cortisol, and its downregulation in obesity. Hydrocortisone is a synthetic glucocorticoid that is commonly prescribed to treat various conditions such as inflammation, allergies, and adrenal insufficiency but is not directly mentioned in the background statement nor linked to pneumonia in any way. + + To establish a connection between hydrocortisone and pneumonia, one would need evidence showing how altered 11beta-HSD1 activity in obesity affects hydrocortisone levels and how these changes could increase susceptibility to pneumonia. The background statement provided does not offer such evidence or implications; therefore, it does not support the initial phrase in question. + + To further clarify, hydrocortisone (cortisol) downregulation due to" +11442939,Hydrocortisone related to prostate cancer,365,"High-dose hydrocortisone treatment given in the first few hours after a traumatic experience was associated with significant favorable changes in the trajectory of exposure to trauma, as expressed by the reduced risk of the development of PTSD post-trauma.",False,"Is the triple 'Hydrocortisone related to prostate cancer' supported by the sentence: 'High-dose hydrocortisone treatment given in the first few hours after a traumatic experience was associated with significant favorable changes in the trajectory of exposure to trauma, as expressed by the reduced risk of the development of PTSD post-trauma.'?","No, the statement does not provide indirect support for the phrase ""Hydrocortisone related to prostate cancer."" The statement discusses the association between high-dose hydrocortisone treatment and reduced risk of post-traumatic stress disorder (PTSD) development after a traumatic experience. This finding is related to psychiatric disorders rather than prostate cancer. Therefore, it does not offer any relevant information or implications regarding hydrocortisone's relationship with prostate cancer." +11089023,Hydrocortisone related to pancreatitis,366,"Under normal conditions, stress induces increased cortisol secretion that counteracts inflammatory reactions.",False,"Is the triple 'Hydrocortisone related to pancreatitis' supported by the sentence: 'Under normal conditions, stress induces increased cortisol secretion that counteracts inflammatory reactions.'?","No, the statement does not provide indirect support for the phrase ""Hydrocortisone related to pancreatitis."" The statement suggests that cortisol, under normal conditions, has an anti-inflammatory effect during stress responses. Hydrocortisone is a synthetic glucocorticoid often used as a replacement therapy for adrenal insufficiency and has potent anti-inflammatory effects similar to those of cortisol. However, this information does not necessarily imply a connection between hydrocortisone use and pancreatitis risk without additional evidence specifically linking these two factors together." +10649902,Hydrocortisone related to myocardial infarction,367,Hydrocortisone (HC) reduced the macrophage content of four murine tumors to less than half of control values.,False,Is the triple 'Hydrocortisone related to myocardial infarction' supported by the sentence: 'Hydrocortisone (HC) reduced the macrophage content of four murine tumors to less than half of control values.'?,"No, the statement ""Hydrocortisone (HC) reduced the macrophage content of four murine tumors to less than half of control values"" does not provide indirect support for the phrase ""Hydrocortisone related to myocardial infarction."" + + The reason for this is that while both statements involve hydrocortisone, they discuss different biological processes: tumor macrophage content in mice and myocardial infarction in humans, respectively. A correlation between hydrocortisone usage and reduced macrophage content in tumors does not necessarily imply any relationship between hydrocortisone and myocardial infarction risk in humans. + + Furthermore, even if there were a correlation between hydrocortisone usage and myocardial infarction risk in humans, it would not necessarily imply causation; other confounding variables could be influencing both hydrocortisone usage and myocardial infarction risk. + + Therefore, while both statements involve hydrocortisone, they discuss different biological processes in different organisms, making it impossible to draw any meaningful connections between them without additional information linking hydrocort" +10522181,Hydrocortisone related to osteoarthritis,368,"Further, because infant formula contains only trace amounts of glucocorticoids, these findings suggest that cortisol in milk is a novel biological pathway through which breastfeeding may protect against later obesity.",False,"Is the triple 'Hydrocortisone related to osteoarthritis' supported by the sentence: 'Further, because infant formula contains only trace amounts of glucocorticoids, these findings suggest that cortisol in milk is a novel biological pathway through which breastfeeding may protect against later obesity.'?","No, the statement does not provide direct or indirect support for the phrase ""Hydrocortisone related to osteoarthritis."" The statement discusses the potential protective effect of breastfeeding against later obesity through cortisol in milk, which is a type of glucocorticoid. However, it does not mention hydrocortisone specifically nor make any connection to osteoarthritis. Hydrocortisone is one type of glucocorticoid but is not explicitly mentioned in the statement, so no inference can be made regarding its relationship to osteoarthritis based on this information alone." +10521296,Hydrocortisone related to eye disorder,369,"Conclusions and Relevance: Among adults with severe sepsis not in septic shock, use of hydrocortisone compared with placebo did not reduce the risk of septic shock within 14 days.",False,"Is the triple 'Hydrocortisone related to eye disorder' supported by the sentence: 'Conclusions and Relevance: Among adults with severe sepsis not in septic shock, use of hydrocortisone compared with placebo did not reduce the risk of septic shock within 14 days.'?","No, the statement does not provide indirect support for the phrase ""Hydrocortisone related to eye disorder"". The conclusion drawn in the statement is about hydrocortisone use in adults with severe sepsis not in septic shock and its effect on reducing septic shock risk within 14 days. There is no mention or implication of any eye disorder in relation to hydrocortisone in this statement." +10518203,Hydrocortisone related to otitis externa,370,These findings suggest that HC may protect against hyperoxic injury in the developing pulmonary vasculature.,False,Is the triple 'Hydrocortisone related to otitis externa' supported by the sentence: 'These findings suggest that HC may protect against hyperoxic injury in the developing pulmonary vasculature.'?,"No, the statement does not provide indirect support for the phrase ""Hydrocortisone related to otitis externa."" The finding suggests that hydrocortisone (HC) may have protective effects against hyperoxic injury in the developing pulmonary vasculature. Otitis externa refers to inflammation or infection of the outer ear canal, which is unrelated to pulmonary vasculature in which hydrocortisone is found to have potential benefits in this study." +10484611,Hydrocortisone related to ulcerative colitis,371,OBJECTIVE: Cortisol clearance is reduced in sepsis and may contribute to the development of impaired adrenocortical function that is thought to contribute to the pathophysiology of critical illness-related corticosteroid insufficiency.,False,Is the triple 'Hydrocortisone related to ulcerative colitis' supported by the sentence: 'OBJECTIVE: Cortisol clearance is reduced in sepsis and may contribute to the development of impaired adrenocortical function that is thought to contribute to the pathophysiology of critical illness-related corticosteroid insufficiency.'?,"No, I would argue that the statement does not provide direct or indirect support for the phrase ""Hydrocortisone related to ulcerative colitis."" The statement discusses cortisol clearance in sepsis and its potential contribution to impaired adrenocortical function in critical illness-related corticosteroid insufficiency. Hydrocortisone is a synthetic form of cortisol (a hormone produced by the adrenal gland), but the statement does not make any mention of ulcerative colitis or hydrocortisone treatment for this condition. + + Ulcerative colitis is an inflammatory bowel disease (IBD) characterized by chronic inflammation in the colon lining. Corticosteroids like hydrocortisone can be used in managing IBD symptoms; however, they do not specifically target ulcerative colitis but rather reduce inflammation more generally in the gut. The statement in question focuses on sepsis-induced corticosteroid insufficiency rather than IBD or ulcerative colitis treatment. + + In conclusion, while hydrocortisone is indeed related to cortisol metabolism, which is" +9718673,Hydrocortisone related to atopic eczema,372,Hydrocortisone therapy was started to prevent adrenal insufficiency before laboratory findings for ACTH (adrenocorticotropic hormone) and cortisol levels.,False,Is the triple 'Hydrocortisone related to atopic eczema' supported by the sentence: 'Hydrocortisone therapy was started to prevent adrenal insufficiency before laboratory findings for ACTH (adrenocorticotropic hormone) and cortisol levels.'?,"No, the statement does not provide direct or indirect support for the phrase ""Hydrocortisone related to atopic eczema"". The statement mentions that hydrocortisone therapy was initiated to prevent adrenal insufficiency due to low ACTH (adrenocorticotropic hormone) and cortisol levels. This is unrelated to atopic eczema treatment as hydrocortisone is also used for various conditions where anti-inflammatory properties are required. The connection between hydrocortisone therapy in this context and atopic eczema is not apparent in the given statement." +9492934,Hydrocortisone related to opiate dependence,373,CONCLUSION: We conclude that intravenous stress doses of hydrocortisone lead to a reduction of systemic inflammation and to a potential improvement in the early outcome of patients undergoing off-pump CABG.,False,Is the triple 'Hydrocortisone related to opiate dependence' supported by the sentence: 'CONCLUSION: We conclude that intravenous stress doses of hydrocortisone lead to a reduction of systemic inflammation and to a potential improvement in the early outcome of patients undergoing off-pump CABG.'?,"No, the statement does not provide any indirect support for the connection between hydrocortisone and opiate dependence. The conclusion in question discusses the effects of intravenous stress doses of hydrocortisone on systemic inflammation in patients undergoing off-pump coronary artery bypass graft (CABG) surgery and its potential impact on early patient outcomes. It does not mention opiate dependence or related topics at all. Therefore, it is not reasonable to infer any relationship between hydrocortisone use and opiate dependence based on the provided conclusion." +9238280,Hydrocortisone related to Sepsis,374,"CONCLUSION: In intubated trauma patients, the use of an intravenous stress-dose of hydrocortisone, compared with placebo, resulted in a decreased risk of hospital-acquired pneumonia.",False,"Is the triple 'Hydrocortisone related to Sepsis' supported by the sentence: 'CONCLUSION: In intubated trauma patients, the use of an intravenous stress-dose of hydrocortisone, compared with placebo, resulted in a decreased risk of hospital-acquired pneumonia.'?","No, the statement ""CONCLUSION: In intubated trauma patients, the use of an intravenous stress-dose of hydrocortisone, compared with placebo, resulted in a decreased risk of hospital-acquired pneumonia"" does not provide indirect support for the phrase ""Hydrocortisone related to Sepsis"". This conclusion is about hydrocortisone use reducing hospital-acquired pneumonia risk in intubated trauma patients compared to placebo. Sepsis is not mentioned in this conclusion; therefore, it does not imply any relationship between hydrocortisone and sepsis." +9235597,Hydrocortisone related to type 1 diabetes mellitus,375,"Early hydrocortisone (HC) treatment may decrease the incidence of bronchopulmonary dysplasia; however, the long-term effects are still under evaluation.",False,"Is the triple 'Hydrocortisone related to type 1 diabetes mellitus' supported by the sentence: 'Early hydrocortisone (HC) treatment may decrease the incidence of bronchopulmonary dysplasia; however, the long-term effects are still under evaluation.'?","No, the statement does not provide direct or indirect support for the phrase ""Hydrocortisone related to type 1 diabetes mellitus."" The statement discusses the use of hydrocortisone (HC) in relation to bronchopulmonary dysplasia, not type 1 diabetes mellitus. Therefore, it does not contribute any evidence or reasoning towards understanding a potential relationship between hydrocortisone and type 1 diabetes mellitus." +8977987,Hydrocortisone related to injury,376,CONCLUSION: Intravenous hydrocortisone reduced the incidence of AF after cardiac surgery.,False,Is the triple 'Hydrocortisone related to injury' supported by the sentence: 'CONCLUSION: Intravenous hydrocortisone reduced the incidence of AF after cardiac surgery.'?,"No, the statement does not provide indirect support for the phrase ""Hydrocortisone related to injury."" The conclusion in question comes from a study that examines the effects of intravenous hydrocortisone on atrial fibrillation (AF) after cardiac surgery. While it demonstrates an association between hydrocortisone use and reduced incidence of AF in this specific context, it does not provide evidence linking hydrocortisone directly to injury. + + To further elaborate on this point: + + 1) The study investigates hydrocortisone use in relation to AF after cardiac surgery - not injury; + 2) Although hydrocortisone is used as an anti-inflammatory agent, which implies its potential involvement in injury response, no direct causal link between hydrocortisone use and injury reduction is established in the provided statement; + 3) The study does not discuss any other potential adverse effects related to injury that may be associated with hydrocortisone use; + 4) The statement does not provide any context about other studies that might support the connection between hydrocortisone use and injury reduction; + 5" +8778414,Hydrocortisone related to Inflammation,377,"Assuming a single dose of hydrocortisone improves sensitivity of peripheral tissues to insulin, it may be an interesting candidate for use in reducing insulin resistance in peripheral tissues of horses with several disease states.",False,"Is the triple 'Hydrocortisone related to Inflammation' supported by the sentence: 'Assuming a single dose of hydrocortisone improves sensitivity of peripheral tissues to insulin, it may be an interesting candidate for use in reducing insulin resistance in peripheral tissues of horses with several disease states.'?","No, the statement does not provide direct or indirect support for the phrase ""Hydrocortisone related to Inflammation"". The statement discusses hydrocortisone's potential impact on insulin resistance in horses, but it does not mention or imply any connection to inflammation. Hydrocortisone is indeed known for its anti-inflammatory effects in various disease states in humans and animals, but that aspect is not addressed in the given statement. Therefore, it cannot be used as evidence to support the claim about hydrocortisone being related to inflammation." +8763179,Hydrocortisone related to toxic shock syndrome,378,Plasma cortisol and glucagon concentrations were not increased markedly except in a case complicated other systemic bacterial infection.,False,Is the triple 'Hydrocortisone related to toxic shock syndrome' supported by the sentence: 'Plasma cortisol and glucagon concentrations were not increased markedly except in a case complicated other systemic bacterial infection.'?,"No, the statement does not provide indirect support for the phrase ""Hydrocortisone related to toxic shock syndrome"". The statement discusses plasma cortisol concentrations in relation to bacterial infection but does not mention hydrocortisone or toxic shock syndrome. Hydrocortisone is a synthetic form of cortisol, but no connection is drawn between it and toxic shock syndrome in this statement." +8625521,Hydrocortisone related to dissociative amnesia,379,"In view of the stimulatory effects of insulin and cortisol on adipogenesis, long-term stimulation of 11betaHSD reductase activity by insulin could aggravate visceral obesity.",False,"Is the triple 'Hydrocortisone related to dissociative amnesia' supported by the sentence: 'In view of the stimulatory effects of insulin and cortisol on adipogenesis, long-term stimulation of 11betaHSD reductase activity by insulin could aggravate visceral obesity.'?","No, the statement ""Hydrocortisone related to dissociative amnesia"" does not receive indirect support from the provided statement about insulin and cortisol stimulating adipogenesis (the process by which preadipocytes become adipocytes, or fat cells) and 11betaHSD reductase activity potentially aggravating visceral obesity (excessive fat accumulation in the abdominal region). + + The given statement is focused on insulin and cortisol's effects on adipogenesis and obesity development, not on their relationship with dissociative amnesia, which is characterized by memory loss due to psychological trauma rather than hormonal imbalances. + + Hydrocortisone is a synthetic glucocorticoid hormone that is often used as an anti-inflammatory drug in medical treatments; it is not related to insulin in terms of structure or function. While both hormones can impact fat metabolism, there is no clear connection between hydrocortisone use and dissociative amnesia based on the provided statement alone. + + Therefore, further information would be required in order" +8615164,Hydrocortisone related to asthma,380,"For this purpose, this review article contends that plasma cortisol is linked to a greater risk of AF.",False,"Is the triple 'Hydrocortisone related to asthma' supported by the sentence: 'For this purpose, this review article contends that plasma cortisol is linked to a greater risk of AF.'?","No, the statement does not provide indirect support for the phrase ""Hydrocortisone related to asthma."" The review article discusses plasma cortisol being linked to a greater risk of atrial fibrillation (AF), not asthma. Hydrocortisone is a synthetic glucocorticoid that mimics cortisol in the body; however, it is not explicitly mentioned in relation to asthma in the statement provided. + + To establish an indirect link between hydrocortisone and asthma in this context, there would need to be evidence connecting cortisol levels (or glucocorticoids like hydrocortisone) to asthma development or exacerbation. Since no such connection is made in the statement provided, we cannot infer support for ""Hydrocortisone related to asthma."" + + In summary, while hydrocortisone is related to cortisol in its glucocorticoid action, there is no explicit connection made between hydrocortisone and asthma in the statement provided. Therefore, it does not offer indirect support for that specific phrase." +8570630,Hydrocortisone related to fibromyalgia,381,"After multivariate analysis, duration of HC stress dose administration was associated with increased risk of mortality (OR 1.11, 95% CI 1.02-1.2, p = 0.021), and total duration of HC treatment was associated with increased risk of sepsis (OR 1.04, 95% CI 1.005-1.075, p = 0.026).",False,"Is the triple 'Hydrocortisone related to fibromyalgia' supported by the sentence: 'After multivariate analysis, duration of HC stress dose administration was associated with increased risk of mortality (OR 1.11, 95% CI 1.02-1.2, p = 0.021), and total duration of HC treatment was associated with increased risk of sepsis (OR 1.04, 95% CI 1.005-1.075, p = 0.026).'?","No, the statement does not provide indirect support for the phrase ""Hydrocortisone related to fibromyalgia."" The provided statement discusses the association between hydrocortisone (HC) stress dose administration duration and mortality risk as well as total duration of HC treatment and sepsis risk in a given population. However, it does not mention fibromyalgia nor provide any information that would imply a relationship between hydrocortisone usage and fibromyalgia." +8017438,Hydrocortisone related to Insulin resistance,382,"Plasma leptin and ghrelin levels in endotoxin-treated dogs were correlated with serum nitric oxide (r = .955 and r = .890; p < .001), procalcitonin (r = .825 and r = .716; p < .001), cortisol (r = .823 and r = .786; p < .001), and hepatorenal injury markers (r = .580 to .745 and r = .393 to .574; p < .05 to .01).",False,"Is the triple 'Hydrocortisone related to Insulin resistance' supported by the sentence: 'Plasma leptin and ghrelin levels in endotoxin-treated dogs were correlated with serum nitric oxide (r = .955 and r = .890; p < .001), procalcitonin (r = .825 and r = .716; p < .001), cortisol (r = .823 and r = .786; p < .001), and hepatorenal injury markers (r = .580 to .745 and r = .393 to .574; p < .05 to .01).'?","No, the statement does not provide direct support for the phrase ""Hydrocortisone related to Insulin resistance"". The statement discusses correlations between various markers in endotoxin-treated dogs, one of which is cortisol (a stress hormone that can be converted into hydrocortisone in humans). However, there is no mention or implication of insulin resistance in the statement. Insulin resistance would involve a decreased response to insulin in cells, leading to high blood glucose levels, which is not mentioned in the provided statement. Therefore, while cortisol (and potentially hydrocortisone) may be related to endotoxin response in dogs, no conclusions can be drawn about its relationship with insulin resistance based on this information alone." +7919367,Hydrocortisone related to adrenocortical insufficiency,383,Contribution of cortisol deficiency to septic shock.,True,Is the triple 'Hydrocortisone related to adrenocortical insufficiency' supported by the sentence: 'Contribution of cortisol deficiency to septic shock.'?,"Yes, there is indirect support for the phrase ""Hydrocortisone related to adrenocortical insufficiency"" from the statement ""Contribution of cortisol deficiency to septic shock."" + + + Justification: + + + Hydrocortisone is a synthetic glucocorticoid hormone that is often used as replacement therapy for adrenocortical insufficiency (also known as Addison’s disease), which is characterized by impaired cortisol secretion from the adrenal glands [1]. Cortisol is a vital stress hormone that helps regulate metabolism and immune response [2]. + + + The statement ""Contribution of cortisol deficiency to septic shock"" implies that cortisol plays an essential role in managing septic shock, which is a severe complication of sepsis that can lead to multi-organ failure [3]. In cases of septic shock, corticosteroids like hydrocortisone can be administered as part of treatment due to their ability to modulate immune response and improve hemodynamic stability [4]. + + + Therefore, since" +7573954,Hydrocortisone related to neoplasm,384,The objective of this study was to demonstrate the effect of stress doses of hydrocortisone during the initial phase of human septic shock on the serum values of the neurospecific protein S-100B in comparison to the inflammation markers interleukin (IL)-8 in serum and polymorphonuclear (PMN) elastase in plasma.,False,Is the triple 'Hydrocortisone related to neoplasm' supported by the sentence: 'The objective of this study was to demonstrate the effect of stress doses of hydrocortisone during the initial phase of human septic shock on the serum values of the neurospecific protein S-100B in comparison to the inflammation markers interleukin (IL)-8 in serum and polymorphonuclear (PMN) elastase in plasma.'?,"No, the statement does not provide indirect support for the phrase ""Hydrocortisone related to neoplasm"". The objective of the study as described is focused on understanding the impact of stress doses of hydrocortisone on serum values of S-100B protein, IL-8 in serum, and PMN elastase in plasma during the initial phase of human septic shock. There is no mention or implication of neoplasm (abnormal growth of cells) in relation to hydrocortisone in this study." +7182905,Hydrocortisone related to obesity disorder,385,"The synergism between insulin and cortisol in stimulating energy deposition, associated with a decreased effect of corticotropin-releasing factor in stimulating energy expenditure, is likely to contribute to the development of obesity.",True,"Is the triple 'Hydrocortisone related to obesity disorder' supported by the sentence: 'The synergism between insulin and cortisol in stimulating energy deposition, associated with a decreased effect of corticotropin-releasing factor in stimulating energy expenditure, is likely to contribute to the development of obesity.'?","Yes, indirectly it does support the phrase ""Hydrocortisone related to obesity disorder"". Hydrocortisone is a type of cortisol, which is mentioned in the statement as having an interaction with insulin in relation to obesity development. The statement explains that cortisol stimulates energy deposition (which can contribute to obesity) and decreases the effect of corticotropin-releasing factor in stimulating energy expenditure (which can also contribute to obesity). Therefore, increased hydrocortisone levels could potentially contribute to obesity development due to these mechanisms mentioned in the statement." +24445107,Hydrocortisone related to Inflammation,386,Higher basal cortisol predicts verbal memory loss in postmenopausal women: Rancho Bernardo Study.,True,Is the triple 'Hydrocortisone related to Inflammation' supported by the sentence: 'Higher basal cortisol predicts verbal memory loss in postmenopausal women: Rancho Bernardo Study.'?,"Yes, there is indirect support for the phrase ""Hydrocortisone related to Inflammation"" in the statement ""Higher basal cortisol predicts verbal memory loss in postmenopausal women: Rancho Bernardo Study."" + + Hydrocortisone is a type of cortisol hormone produced by the adrenal glands in response to stress. Cortisol has been shown to have immunosuppressive effects, including reducing inflammation in the body (Munck et al., 1984). The Rancho Bernardo Study found that higher basal cortisol (which includes hydrocortisone) levels predict verbal memory loss in postmenopausal women (Lupien et al., 1998). + + Although this study does not explicitly investigate hydrocortisone or inflammation, it does suggest that cortisol levels—and by extension hydrocortisone—are associated with cognitive decline in postmenopausal women. This finding is relevant because chronic inflammation is known to contribute to cognitive decline in older adults (Mrak & Griffin, 2005). Thus" +24030854,Hydrocortisone related to Hypoxemia,387,"A growing body of evidence now suggests that endogenous cortisol, which is produced in significant quantities by the body in a diurnal rhythm, is an important regulator of allergic disease expression and allergic inflammatory responses: lung function varies along with plasma cortisol levels; the number of circulating inflammatory cells varies with plasma cortisol levels; and low levels of endogenous cortisol may be associated with risk for asthma.",False,"Is the triple 'Hydrocortisone related to Hypoxemia' supported by the sentence: 'A growing body of evidence now suggests that endogenous cortisol, which is produced in significant quantities by the body in a diurnal rhythm, is an important regulator of allergic disease expression and allergic inflammatory responses: lung function varies along with plasma cortisol levels; the number of circulating inflammatory cells varies with plasma cortisol levels; and low levels of endogenous cortisol may be associated with risk for asthma.'?","No, the statement does not provide direct or indirect support for the phrase ""Hydrocortisone related to Hypoxemia."" + + The statement discusses the role of endogenous cortisol in allergic disease expression and inflammatory responses, particularly in lung function and circulating inflammatory cells. Hydrocortisone is a synthetic form of cortisol, a glucocorticoid hormone, which is often used as a medication to reduce inflammation in various conditions such as asthma, arthritis, and dermatologic diseases. + + Hypoxemia refers to lower-than-normal levels of oxygen in the blood. While hydrocortisone could potentially impact oxygen levels indirectly by modulating inflammation in lung tissue (which might affect gas exchange), there is no explicit connection made between hydrocortisone and hypoxemia in either the provided statement or general medical knowledge. + + Therefore, further investigation would be required to establish any potential relationship between hydrocortisone use and hypoxemia risk." +12533519,Hydrocortisone related to Insulin resistance,388,"In conclusion, the data presented here suggest that cortisol can contribute to insulin resistance in ponies with hyperlipoproteinaemia.",True,"Is the triple 'Hydrocortisone related to Insulin resistance' supported by the sentence: 'In conclusion, the data presented here suggest that cortisol can contribute to insulin resistance in ponies with hyperlipoproteinaemia.'?","Yes, the statement ""In conclusion, the data presented here suggest that cortisol can contribute to insulin resistance in ponies with hyperlipoproteinaemia"" does lend indirect support to the phrase ""Hydrocortisone related to Insulin resistance"". + + Hydrocortisone is a synthetic form of cortisol, a glucocorticoid hormone that is naturally produced in humans and animals. Cortisol is known to have various metabolic effects, including increasing blood glucose levels and potentially contributing to insulin resistance. + + The study in question suggests that cortisol can contribute to insulin resistance in ponies with hyperlipoproteinaemia. Given that hydrocortisone is a synthetic form of cortisol, it stands to reason that hydrocortisone could also contribute to insulin resistance under similar circumstances. However, it is important to note that this is an indirect inference, as the study does not explicitly test the effects of hydrocortisone on insulin resistance. Further studies would be needed to confirm this relationship specifically for hydrocortisone." +27747116,Hydrocortisone causes toxic shock syndrome,389,"OBJECTIVE: To investigate the relationship of cortisol concentrations during the first week of life to patent ductus arteriosus (PDA), markers of lung inflammation, and respiratory outcome in very low birth weight infants.",False,"Is the triple 'Hydrocortisone causes toxic shock syndrome' supported by the sentence: 'OBJECTIVE: To investigate the relationship of cortisol concentrations during the first week of life to patent ductus arteriosus (PDA), markers of lung inflammation, and respiratory outcome in very low birth weight infants.'?","No, the statement does not provide indirect support for the phrase ""Hydrocortisone causes toxic shock syndrome."" The objective is investigating cortisol concentrations in relation to PDA, lung inflammation markers, and respiratory outcome in very low birth weight infants. Hydrocortisone is not mentioned in the objective nor is there any connection made between it and toxic shock syndrome in the statement provided." +27747115,Hydrocortisone causes Sepsis,390,Oral pH-modified release budesonide versus 6-methylprednisolone in active Crohn's disease.,False,Is the triple 'Hydrocortisone causes Sepsis' supported by the sentence: 'Oral pH-modified release budesonide versus 6-methylprednisolone in active Crohn's disease.'?,"No, the statement ""Oral pH-modified release budesonide versus 6-methylprednisolone in active Crohn's disease"" does not provide indirect support for the claim that ""Hydrocortisone causes Sepsis."" This study compares two treatments for Crohn's disease - an oral pH-modified release formulation of budesonide and 6-methylprednisolone - but it does not mention hydrocortisone nor make any connection between these treatments and sepsis development. Hydrocortisone is a type of corticosteroid hormone used in various medical treatments; however, its use does not inherently imply sepsis as an outcome. Sepsis is typically caused by an overwhelming immune response to an infection rather than direct administration of corticosteroids such as hydrocortisone." +27073884,Hydrocortisone causes atopic eczema,391,Pharmacokinetics of high dose methylprednisolone and use in hematological malignancies.,False,Is the triple 'Hydrocortisone causes atopic eczema' supported by the sentence: 'Pharmacokinetics of high dose methylprednisolone and use in hematological malignancies.'?,"No, the statement ""Pharmacokinetics of high dose methylprednisolone and use in hematological malignancies"" does not provide any direct or indirect support for the claim that ""Hydrocortisone causes atopic eczema"". The two statements discuss different topics: one is about pharmacokinetics (the absorption, distribution, metabolism, and excretion) of methylprednisolone in high doses in relation to hematological malignancies (cancers affecting blood cells), while the other is about hydrocortisone potentially causing atopic eczema (a chronic inflammatory skin condition). + + To support the claim that ""Hydrocortisone causes atopic eczema"", evidence would need to show that hydrocortisone exposure leads to an increased likelihood of developing atopic eczema. The statement about methylprednisolone does not provide any information about hydrocortisone, its pharmacological properties, or its potential effects on atopic eczema. Therefore, it cannot be used as support for that claim." +25383174,Hydrocortisone causes fibromyalgia,392,"Methylprednisolone in advanced chronic lymphocytic leukaemia: rationale for, and effectiveness of treatment suggested by DiSC assay.",False,"Is the triple 'Hydrocortisone causes fibromyalgia' supported by the sentence: 'Methylprednisolone in advanced chronic lymphocytic leukaemia: rationale for, and effectiveness of treatment suggested by DiSC assay.'?","No, the statement does not provide any indirect support for the claim that hydrocortisone causes fibromyalgia. The two statements discuss different topics: one is about methylprednisolone treatment in advanced chronic lymphocytic leukaemia, while the other is about hydrocortisone potentially causing fibromyalgia. + + Furthermore, these two steroids have different properties and uses in medicine; therefore, there is no logical connection between their effects on patients. Methylprednisolone is primarily used as an anti-inflammatory drug in various conditions like arthritis and allergies, while hydrocortisone is used as both an anti-inflammatory drug as well as replacement therapy in adrenal insufficiency. + + The statement only implies that methylprednisolone may be an effective treatment for advanced chronic lymphocytic leukaemia based on DiSC assay results; it does not suggest any connection between steroid use (including hydrocortisone) and fibromyalgia development. Fibromyalgia is considered a disorder of pain regulation with complex interactions between genetic, environmental," +25205462,Hydrocortisone causes hypotensive disorder,393,The effects of intravenous pulse methylprednisolone on immunological and inflammatory processes in ankylosing spondylitis.,False,Is the triple 'Hydrocortisone causes hypotensive disorder' supported by the sentence: 'The effects of intravenous pulse methylprednisolone on immunological and inflammatory processes in ankylosing spondylitis.'?,"No, the statement does not provide indirect support for the phrase ""Hydrocortisone causes hypotensive disorder."" The statement discusses the effects of intravenous pulse methylprednisolone on immunological and inflammatory processes in ankylosing spondylitis, which is unrelated to Hydrocortisone or hypotensive disorder. Hydrocortisone is a different glucocorticoid medication than methylprednisolone; therefore, any potential effects on blood pressure would need separate evaluation. Additionally, hypotensive disorder refers to abnormally low blood pressure, not high blood pressure as might be more commonly associated with corticosteroids like Hydrocortisone." +20591759,Hydrocortisone causes Hypoxemia,394,The effect of methylprednisolone (MP) on the cell kinetic response to cyclophosphamide (CP) and Adriamycin (ADR) in C3H/HeJ spontaneous mammary tumors and hematopoietic tissue was investigated.,False,Is the triple 'Hydrocortisone causes Hypoxemia' supported by the sentence: 'The effect of methylprednisolone (MP) on the cell kinetic response to cyclophosphamide (CP) and Adriamycin (ADR) in C3H/HeJ spontaneous mammary tumors and hematopoietic tissue was investigated.'?,"No, the statement does not provide indirect support for the claim that ""Hydrocortisone causes Hypoxemia."" The study mentioned in the statement investigates the effect of methylprednisolone (MP) on cyclophosphamide (CP) and Adriamycin (ADR) in C3H/HeJ spontaneous mammary tumors and hematopoietic tissue. Hydrocortisone is not mentioned in the study, and there is no information linking it to hypoxemia (a condition characterized by low levels of oxygen in the blood) in this context." +18446972,Hydrocortisone causes congenital adrenal hyperplasia,395,High-dose intravenous methyl-prednisolone in chronic polymyositis/dermatomyositis.,False,Is the triple 'Hydrocortisone causes congenital adrenal hyperplasia' supported by the sentence: 'High-dose intravenous methyl-prednisolone in chronic polymyositis/dermatomyositis.'?,"No, the statement does not provide indirect support for the phrase ""Hydrocortisone causes congenital adrenal hyperplasia."" The statement discusses high-dose intravenous methyl-prednisolone used in treating chronic polymyositis/dermatomyositis, which is unrelated to Hydrocortisone or congenital adrenal hyperplasia (CAH). + + CAH is primarily caused by genetic mutations affecting enzymes in steroid biosynthesis pathways in the adrenal glands; it is not caused by exposure to Hydrocortisone or other glucocorticoids during treatment for other conditions. + + However, glucocorticoids like Hydrocortisone may affect fetal development when taken during pregnancy due to their ability to cross the placenta; they may increase the risk for certain complications such as preterm birth and low birth weight but not congenital adrenal hyperplasia specifically. + + Therefore, it is crucial to differentiate between causation (Hydrocortisone causing CAH) and potential associations (Hydrocort" +18240145,Hydrocortisone causes injury,396,Comparing Intratympanic Gentamicin with Methylprednisolone in Meniere's Disease with Non-Serviceable Hearing.,False,Is the triple 'Hydrocortisone causes injury' supported by the sentence: 'Comparing Intratympanic Gentamicin with Methylprednisolone in Meniere's Disease with Non-Serviceable Hearing.'?,"No, the statement ""Comparing Intratympanic Gentamicin with Methylprednisolone in Meniere's Disease with Non-Serviceable Hearing"" does not provide indirect support for the phrase ""Hydrocortisone causes injury."" The statement discusses a comparison between Intratympanic Gentamicin and Methylprednisolone in Meniere's Disease with Non-Serviceable Hearing. Hydrocortisone is not mentioned in this statement; therefore, it cannot provide indirect support for any claim about Hydrocortisone causing injury. + + However, it is important to note that Hydrocortisone is a type of corticosteroid, similar to Methylprednisolone, which is mentioned in the statement. Corticosteroids have been associated with various side effects such as increased risk for infections, osteoporosis, diabetes mellitus, hypertension, psychological effects among others when used systemically (Boumpas et al., 1993). But these potential adverse effects do not necessarily translate into ""injury"" in every context. + + In conclusion, while cortic" +17359303,Hydrocortisone causes influenza,397,"High-dose methylprednisolone, vincristine, MTX, and ara-C (SOMA) as initial bulk reducing therapy in non-Hodgkin's lymphoma of unfavorable histology: preliminary results of an ongoing phase II study.",False,"Is the triple 'Hydrocortisone causes influenza' supported by the sentence: 'High-dose methylprednisolone, vincristine, MTX, and ara-C (SOMA) as initial bulk reducing therapy in non-Hodgkin's lymphoma of unfavorable histology: preliminary results of an ongoing phase II study.'?","No, the statement does not provide any indirect support for the claim that ""Hydrocortisone causes influenza."" The statement discusses initial bulk reducing therapy in non-Hodgkin's lymphoma using high-dose methylprednisolone along with other drugs. There is no mention or implication of hydrocortisone causing influenza in either the original claim or in general medical knowledge. Influenza is caused by viruses, not by hydrocortisone or other steroid medications like methylprednisolone." +13585273,"Hydrocortisone causes dermatitis, atopic",398,A Prospective Study Comparing the Efficacy of Local Injection of Platelet-Rich Plasma (PRP) vs Methylprednisolone in Plantar Fasciitis.,False,"Is the triple 'Hydrocortisone causes dermatitis, atopic' supported by the sentence: 'A Prospective Study Comparing the Efficacy of Local Injection of Platelet-Rich Plasma (PRP) vs Methylprednisolone in Plantar Fasciitis.'?","No, the statement does not provide direct or indirect support for the claim that ""Hydrocortisone causes dermatitis, atopic."" The study in question compares the efficacy of PRP injections versus methylprednisolone injections for treating plantar fasciitis. Hydrocortisone is not mentioned in the study title or abstract provided. + + To further elaborate on why there is no support for the claim: + + - The study focuses on comparing two treatments for plantar fasciitis, PRP injections and methylprednisolone injections. + - Hydrocortisone is not mentioned as either a treatment option or an adverse effect in the study title or abstract. + - Hydrocortisone is chemically distinct from methylprednisolone; therefore, any potential adverse effects would not necessarily be shared between these two compounds. + - Dermatitis is not mentioned as an adverse effect for either treatment in the study title or abstract. + + In conclusion, there is no indirect support for the claim that ""Hydrocortisone causes dermatitis, atopic"" based on the provided" +12645476,Hydrocortisone causes obesity disorder,399,A controlled trial of 6-methylprednisolone in acute alcoholic hepatitis.,False,Is the triple 'Hydrocortisone causes obesity disorder' supported by the sentence: 'A controlled trial of 6-methylprednisolone in acute alcoholic hepatitis.'?,"No, the statement ""A controlled trial of 6-methylprednisolone in acute alcoholic hepatitis"" does not provide indirect support for the phrase ""Hydrocortisone causes obesity disorder."" + + The reason is that 6-methylprednisolone is not hydrocortisone, although they both belong to the class of steroid hormones known as glucocorticoids. While glucocorticoids can have various side effects including weight gain due to increased appetite, water retention, and fat redistribution, it does not automatically mean that hydrocortisone specifically causes obesity disorder based on a study involving 6-methylprednisolone. + + Moreover, acute alcoholic hepatitis is not obesity disorder; it is a condition in which the liver swells (inflames) due to excessive consumption of alcohol. Therefore, even if there was a direct study linking hydrocortisone to obesity disorder, it would still be inappropriate to infer such a link based solely on another study involving a different steroid hormone in an unrelated medical condition." +10068843,Hydrocortisone causes Inflammation,400,[Short-term therapy with methylprednisolone in exacerbated obstructive respiratory tract diseases].,False,Is the triple 'Hydrocortisone causes Inflammation' supported by the sentence: '[Short-term therapy with methylprednisolone in exacerbated obstructive respiratory tract diseases].'?,"No, the statement does not provide any indirect support for the claim that ""Hydrocortisone causes Inflammation."" The statement discusses short-term therapy using methylprednisolone in exacerbated obstructive respiratory tract diseases but does not mention Hydrocortisone or Inflammation in any way that could imply causation or correlation between Hydrocortisone use and Inflammation. + + Hydrocortisone is actually an anti-inflammatory drug used in treating various conditions associated with inflammation such as allergies, arthritis, asthma, and autoimmune disorders among others. Therefore, it is unlikely that Hydrocortisone would cause inflammation based on its well-established pharmacological properties and clinical applications. + + It is essential to critically evaluate each piece of evidence in its entirety while considering the broader context before drawing any conclusions about related but distinct concepts. This helps maintain accuracy in interpreting scientific literature while minimizing unfounded assumptions that could lead to misinformation." +9850315,Hydrocortisone causes dissociative amnesia,401,Methylprednisolone and 60 Days in Hospital Survival in Coronavirus Disease 2019 Pneumonia.,False,Is the triple 'Hydrocortisone causes dissociative amnesia' supported by the sentence: 'Methylprednisolone and 60 Days in Hospital Survival in Coronavirus Disease 2019 Pneumonia.'?,"No, the statement ""Methylprednisolone and 60 Days in Hospital Survival in Coronavirus Disease 2019 Pneumonia"" does not provide indirect support for the claim that ""Hydrocortisone causes dissociative amnesia"". + + The statement in question is a title of a medical study that investigates the effects of Methylprednisolone on survival rates in COVID-19 patients. It does not mention Hydrocortisone or dissociative amnesia at all. Therefore, it does not offer any form of support for the claim about Hydrocortisone causing dissociative amnesia. + + Furthermore, even if the study had mentioned Hydrocortisone, it would still not provide indirect support for the claim unless it specifically investigated and found a link between Hydrocortisone and dissociative amnesia. Correlation does not imply causation, and without a direct investigation into the relationship between Hydrocortisone and dissociative amnesia, no conclusions can be drawn about such a relationship based on this study alone. + + It is important to note that making" +9318796,Hydrocortisone causes adrenocortical insufficiency,402,Intra-Carpal Injection of Ozone versus Methylprednisolone in Carpal Tunnel Syndrome of Systemic Sclerosis Patients: A Randomized Single-Blind Clinical Trial.,False,Is the triple 'Hydrocortisone causes adrenocortical insufficiency' supported by the sentence: 'Intra-Carpal Injection of Ozone versus Methylprednisolone in Carpal Tunnel Syndrome of Systemic Sclerosis Patients: A Randomized Single-Blind Clinical Trial.'?,"No, the statement ""Hydrocortisone causes adrenocortical insufficiency"" does not receive indirect support from the provided study titled ""Intra-Carpal Injection of Ozone versus Methylprednisolone in Carpal Tunnel Syndrome of Systemic Sclerosis Patients: A Randomized Single-Blind Clinical Trial."" + + The reason for my decision is that hydrocortisone is not mentioned nor used in the study as an experimental agent; hence there is no direct evaluation of its effects on adrenocortical function in this study population. The study compares ozone injections to methylprednisolone injections for treating carpal tunnel syndrome in patients with systemic sclerosis. + + However, I would like to emphasize that adrenocortical insufficiency is indeed a known potential side effect associated with long-term use and high doses of hydrocortisone and other corticosteroids due to their suppressive effect on the hypothalamic-pituitary-adrenal (HPA) axis function (Arnaldi et al., 2009). But in order for a" +9145908,Hydrocortisone causes otitis externa,403,Methylprednisolone Pulses in West Syndrome: A New Weapon in the Armory-Is it Needed?,False,Is the triple 'Hydrocortisone causes otitis externa' supported by the sentence: 'Methylprednisolone Pulses in West Syndrome: A New Weapon in the Armory-Is it Needed?'?,"No, the statement ""Methylprednisolone Pulses in West Syndrome: A New Weapon in the Armory-Is it Needed?"" does not provide indirect support for the claim that ""Hydrocortisone causes otitis externa."" The statement discusses methylprednisolone pulses as a potential treatment for West Syndrome in children; it does not mention hydrocortisone or otitis externa at all. Therefore, there is no connection between these two statements that would allow for indirect support from one to another. + + The misinterpretation here might stem from conflating different types of corticosteroids (hydrocortisone, methylprednisolone) or confusing their different clinical applications (otitis externa treatment vs West Syndrome treatment). As a computational biologist, it is crucial to stay focused on the specific evidence at hand and avoid drawing broad conclusions based on tenuous connections between unrelated studies or statements." +8699464,Hydrocortisone causes adrenal cortex neoplasm,404,Patient underwent treatment with milrinone and methylprednisolone that showed reduction in myocardial inflammation and significantly improved myocardial contractility.,False,Is the triple 'Hydrocortisone causes adrenal cortex neoplasm' supported by the sentence: 'Patient underwent treatment with milrinone and methylprednisolone that showed reduction in myocardial inflammation and significantly improved myocardial contractility.'?,"No, the statement does not provide any indirect support for the claim that ""Hydrocortisone causes adrenal cortex neoplasm"". The patient in question was treated with milrinone and methylprednisolone, not hydrocortisone. Furthermore, the positive effects on myocardial inflammation and contractility mentioned in the statement do not imply any connection to adrenal cortex neoplasm. Hydrocortisone is indeed a glucocorticoid like methylprednisolone, but it is not mentioned in the statement, so no inference can be made about its potential effects on adrenal cortex neoplasm based on this information alone." +8657746,Hydrocortisone causes neoplasm,405,"Neurologically, the therapeutic dosages of anticoagulants are linked to the high incidence of thrombotic complexities, while methylprednisolone is associated with myopathy.",False,"Is the triple 'Hydrocortisone causes neoplasm' supported by the sentence: 'Neurologically, the therapeutic dosages of anticoagulants are linked to the high incidence of thrombotic complexities, while methylprednisolone is associated with myopathy.'?","No, the statement does not provide indirect support for the claim that hydrocortisone causes neoplasm. The statement discusses neurological side effects associated with anticoagulants and myopathy linked to methylprednisolone, but it does not mention hydrocortisone or neoplasm (abnormal tissue growth). To provide indirect support for the original claim, there should be some connection between hydrocortisone and neoplasm in the statement, either explicitly stated or implied through related concepts. As it stands, there is no such connection in the given statement. + + However, it is important to note that hydrocortisone is a type of steroid hormone that can potentially influence cell growth and proliferation, which could be associated with neoplasm formation in certain contexts. Nonetheless, based on the provided statement alone, there is no evidence supporting such a link between hydrocortisone and neoplasm formation. Additional information or evidence would be required for an accurate assessment of such a claim." +7929803,Hydrocortisone causes Insulin resistance,406,"Conclusion: Based on the current data, the efficacy and safety of local injection of triamcinolone and methylprednisolone at doses of 20 and 40 mg were associated with a significant improvement in pain, functional status, and strength.",False,"Is the triple 'Hydrocortisone causes Insulin resistance' supported by the sentence: 'Conclusion: Based on the current data, the efficacy and safety of local injection of triamcinolone and methylprednisolone at doses of 20 and 40 mg were associated with a significant improvement in pain, functional status, and strength.'?","No, the statement does not provide indirect support for the claim that ""Hydrocortisone causes Insulin resistance."" The conclusion presented is about the efficacy and safety of local injections of triamcinolone and methylprednisolone at specific doses in improving pain, functional status, and strength. Hydrocortisone is not mentioned in the statement; therefore, it does not offer any insight into its potential relationship with insulin resistance. + + Insulin resistance refers to the condition where cells in the body become less responsive to insulin, leading to impaired glucose uptake and metabolism. Corticosteroids such as hydrocortisone, triamcinolone, and methylprednisolone have been associated with insulin resistance; however, it is essential to evaluate each claim based on relevant evidence specific to that corticosteroid. + + In summary, without explicit mention or evidence linking hydrocortisone to insulin resistance in the provided statement, it is inappropriate to infer support for such a claim based on this information alone." +7432490,Hydrocortisone causes pancreatitis,407,OBJECTIVE: To validate the responsiveness of cerebrospinal fluid (CSF) inflammatory biomarkers to treatment with natalizumab and methylprednisolone in progressive MS and to examine the relationship between CSF inflammatory and tissue damage biomarkers.,False,Is the triple 'Hydrocortisone causes pancreatitis' supported by the sentence: 'OBJECTIVE: To validate the responsiveness of cerebrospinal fluid (CSF) inflammatory biomarkers to treatment with natalizumab and methylprednisolone in progressive MS and to examine the relationship between CSF inflammatory and tissue damage biomarkers.'?,"No, the statement does not provide indirect support for the claim that ""Hydrocortisone causes pancreatitis."" The objective in question focuses on validating the responsiveness of cerebrospinal fluid (CSF) inflammatory biomarkers in progressive MS patients undergoing treatment with natalizumab and methylprednisolone, as well as examining the relationship between CSF inflammatory and tissue damage biomarkers in these patients. There is no mention of hydrocortisone in the statement nor any information linking it to pancreatitis." +26997315,Hydrocortisone affects congenital adrenal hyperplasia,408,The region was identified as a significant predictor of use of intravenous methylprednisolone in MCD and MN patients.,False,Is the triple 'Hydrocortisone affects congenital adrenal hyperplasia' supported by the sentence: 'The region was identified as a significant predictor of use of intravenous methylprednisolone in MCD and MN patients.'?,"No, the statement does not provide indirect support for the phrase ""Hydrocortisone affects congenital adrenal hyperplasia."" The reason is that methylprednisolone is not hydrocortisone, although both are glucocorticoids used in treating various medical conditions. Methylprednisolone is often used in cases where rapid action is required due to its relatively higher potency compared to hydrocortisone. + + Furthermore, congenital adrenal hyperplasia (CAH) is primarily managed by controlling cortisol levels in the body through medications like hydrocortisone; it does not typically involve intravenous methylprednisolone therapy as mentioned in the statement. Therefore, since there is no direct nor indirect connection between hydrocortisone's effect on congenital adrenal hyperplasia and methylprednisolone use in MCD and MN patients, it does not lend support to the original phrase in question." +26940919,Hydrocortisone affects cardiac arrest,409,"Clinical commentary on ""Two cases of anaphylactic shock by methylprednisolone in neuromyelitis optica"".",False,"Is the triple 'Hydrocortisone affects cardiac arrest' supported by the sentence: 'Clinical commentary on ""Two cases of anaphylactic shock by methylprednisolone in neuromyelitis optica"".'?","No, the statement ""Clinical commentary on 'Two cases of anaphylactic shock by methylprednisolone in neuromyelitis optica'"" does not provide direct or indirect support for the phrase ""Hydrocortisone affects cardiac arrest."" Methylprednisolone is a glucocorticoid steroid similar to hydrocortisone but is not identical in its pharmacological effects on the human body. The article being referenced is about two cases of anaphylactic shock caused by methylprednisolone in patients with neuromyelitis optica; it does not mention hydrocortisone or its potential effects on cardiac arrest. + + To provide indirect support for ""Hydrocortisone affects cardiac arrest,"" there would need to be some connection between methylprednisolone, hydrocortisone, and cardiac arrest in the statement or study referenced. However, in this case, no such link is present. + + It is essential not only to consider whether two statements share keywords but also whether they have logical connections based on established biological knowledge and mechanisms. In some instances, two medicines may have similar effects due" +26840479,Hydrocortisone affects myocardial infarction,410,CONCLUSION: Results show that inhalation of budesonide (2 mg 3 times/day) and systemic methylprednisolone (40 mg/day) had similar clinical outcome in AECOPD.,False,Is the triple 'Hydrocortisone affects myocardial infarction' supported by the sentence: 'CONCLUSION: Results show that inhalation of budesonide (2 mg 3 times/day) and systemic methylprednisolone (40 mg/day) had similar clinical outcome in AECOPD.'?,"No, the statement does not provide indirect support for the phrase ""Hydrocortisone affects myocardial infarction."" The conclusion in the statement refers to two different medications (budesonide and methylprednisolone) being used in chronic obstructive pulmonary disease (COPD), not hydrocortisone specifically. Moreover, it discusses their clinical outcomes in AECOPD (acute exacerbations in COPD) rather than myocardial infarction (heart attack). + + To establish indirect support for ""Hydrocortisone affects myocardial infarction,"" there should be some connection between hydrocortisone, myocardial infarction, or related cardiovascular events in the provided statement. However, no such link exists here." +24701128,Hydrocortisone affects Sepsis,411,A Clinical Trial Comparing the Safety and Efficacy of Topical Tacrolimus versus Methylprednisolone in Ocular Graft-versus-Host Disease.,False,Is the triple 'Hydrocortisone affects Sepsis' supported by the sentence: 'A Clinical Trial Comparing the Safety and Efficacy of Topical Tacrolimus versus Methylprednisolone in Ocular Graft-versus-Host Disease.'?,"No, the statement ""A Clinical Trial Comparing the Safety and Efficacy of Topical Tacrolimus versus Methylprednisolone in Ocular Graft-versus-Host Disease"" does not provide indirect support for the phrase ""Hydrocortisone affects Sepsis."" The clinical trial focuses on comparing two treatments for ocular graft-versus-host disease, topical tacrolimus and methylprednisolone. Hydrocortisone is not mentioned in the statement, nor is there any connection made between sepsis and these treatments. Therefore, it is not possible to draw any conclusions about hydrocortisone's effect on sepsis based on this statement alone." +21274202,Hydrocortisone affects osteoarthritis,412,The purpose of this study was to evaluate the efficacy of supraperiosteal injection of methylprednisolone compared with an oral tablet form and intravenous (i.v.) injection in the prevention of postoperative pain and oedema associated with inflammation.,False,Is the triple 'Hydrocortisone affects osteoarthritis' supported by the sentence: 'The purpose of this study was to evaluate the efficacy of supraperiosteal injection of methylprednisolone compared with an oral tablet form and intravenous (i.v.) injection in the prevention of postoperative pain and oedema associated with inflammation.'?,"No, the statement does not provide indirect support for the claim that ""Hydrocortisone affects osteoarthritis"". The study mentioned is focused on comparing different methods of administering methylprednisolone in preventing postoperative pain and edema associated with inflammation. Hydrocortisone is not mentioned in the statement at all; hence it cannot be inferred that it has any effect on osteoarthritis based on this information alone. + + The study in question involves methylprednisolone, which belongs to the class of glucocorticoids like hydrocortisone but is not identical in its biological effects. Moreover, even if hydrocortisone were involved in such a study, it would still be important to consider factors like dosage, duration, patient demographics, etc., before making any definitive conclusions about its potential impact on osteoarthritis conditions. + + In conclusion, while both hydrocortisone and methylprednisolone belong to the same class of drugs (glucocorticoids), they cannot be used interchangeably in all cases due to differences in their pharmacokinetics and pharmac" +20701310,Hydrocortisone affects psoriasis,413,Gamma globulin and methylprednisolone in idiopathic thrombocytopenic purpura.,False,Is the triple 'Hydrocortisone affects psoriasis' supported by the sentence: 'Gamma globulin and methylprednisolone in idiopathic thrombocytopenic purpura.'?,"No, the statement ""Gamma globulin and methylprednisolone in idiopathic thrombocytopenic purpura"" does not provide indirect support for the claim that ""hydrocortisone affects psoriasis."" The statement discusses two treatments (gamma globulin and methylprednisolone) used for idiopathic thrombocytopenic purpura (ITP), a disorder characterized by an abnormally low platelet count in the blood. Hydrocortisone is not mentioned in the statement, nor does it have any direct or indirect connection to psoriasis treatment. + + However, it is important to note that both gamma globulin (immunoglobulin) and methylprednisolone (a corticosteroid) have been used in various dermatological conditions, including psoriasis. Hydrocortisone is another type of corticosteroid that is also used in treating psoriasis; nonetheless, the initial statement does not provide any evidence or support for hydrocortisone's impact on psoriasis specifically. + + In conclusion, while there might be connections between" +20336537,Hydrocortisone affects dermatitis,414,Methylprednisolone and hepatotoxicity in Graves' ophthalmopathy.,False,Is the triple 'Hydrocortisone affects dermatitis' supported by the sentence: 'Methylprednisolone and hepatotoxicity in Graves' ophthalmopathy.'?,"No, the statement ""Methylprednisolone and hepatotoxicity in Graves' ophthalmopathy"" does not provide indirect support for the claim that ""Hydrocortisone affects dermatitis."" The two statements discuss different corticosteroids (Methylprednisolone vs Hydrocortisone) and their respective effects on different medical conditions (hepatotoxicity in Graves' ophthalmopathy vs dermatitis). Thus, they do not share enough common ground to establish indirect support for one another. + + However, it is important to note that both Hydrocortisone and Methylprednisolone belong to the class of medications called corticosteroids, which have anti-inflammatory effects that could potentially impact various medical conditions such as dermatitis and Graves' ophthalmopathy. But without additional information connecting these two specific corticosteroids and their effects on dermatitis in particular, it is not valid to infer indirect support from one statement for another based on their shared class membership alone." +20137862,Hydrocortisone affects fibromyalgia,415,"In orthognathic surgery, methylprednisolone > or =85 mg administered intravenously seemed sufficient to produce a significant decrease in edema, and several trials pointed toward a neuroregeneration effect, but no statistical analysis could be performed.",False,"Is the triple 'Hydrocortisone affects fibromyalgia' supported by the sentence: 'In orthognathic surgery, methylprednisolone > or =85 mg administered intravenously seemed sufficient to produce a significant decrease in edema, and several trials pointed toward a neuroregeneration effect, but no statistical analysis could be performed.'?","No, the statement does not provide indirect support for the phrase ""Hydrocortisone affects fibromyalgia."" The statement discusses the effects of methylprednisolone in orthognathic surgery, not hydrocortisone in fibromyalgia patients. Methylprednisolone is a synthetic glucocorticoid, similar to hydrocortisone (a natural glucocorticoid), but they are not identical substances with identical effects across different medical conditions. Furthermore, fibromyalgia is distinct from edema associated with orthognathic surgery; hence, no inferences can be drawn about hydrocortisone's potential impact on fibromyalgia based on this statement alone." +19555227,Hydrocortisone affects pneumonia,416,Response of symptoms and synovitis to intra-muscular methylprednisolone in osteoarthritis of the hand: an ultrasonographic study.,False,Is the triple 'Hydrocortisone affects pneumonia' supported by the sentence: 'Response of symptoms and synovitis to intra-muscular methylprednisolone in osteoarthritis of the hand: an ultrasonographic study.'?,"No, the statement ""Response of symptoms and synovitis to intra-muscular methylprednisolone in osteoarthritis of the hand: an ultrasonographic study"" does not provide indirect support for the claim that ""Hydrocortisone affects pneumonia."" + + The reason is that methylprednisolone is not hydrocortisone; they belong to different classes within the corticosteroid family, despite sharing some therapeutic effects in treating inflammation. Methylprednisolone is a synthetic glucocorticoid used primarily for its potent anti-inflammatory effects in various conditions such as osteoarthritis (as indicated in the study). In contrast, hydrocortisone is an endogenous glucocorticoid produced by the human adrenal gland that has both glucocorticoid (anti-inflammatory) and mineralocorticoid (sodium-retaining) activities. + + Moreover, the study focuses on osteoarthritis of the hand, which is not related to pneumonia; therefore, there is no implied association between hydro" +19531871,Hydrocortisone affects atrial fibrillation,417,Long-term results of high-dose methylprednisolone in aplastic anemia.,False,Is the triple 'Hydrocortisone affects atrial fibrillation' supported by the sentence: 'Long-term results of high-dose methylprednisolone in aplastic anemia.'?,"No, the statement ""Long-term results of high-dose methylprednisolone in aplastic anemia"" does not provide indirect support for the claim that ""Hydrocortisone affects atrial fibrillation."" + + + The two statements discuss different medical conditions (aplastic anemia vs atrial fibrillation) and use different steroids (methylprednisolone vs hydrocortisone). Methylprednisolone is a synthetic glucocorticoid used primarily for its potent anti-inflammatory effects, while hydrocortisone is also a glucocorticoid but is primarily used for its anti-stress and anti-inflammatory effects as well as its mineralocorticoid properties (i.e., fluid and electrolyte balance). + + + Although both steroids belong to the glucocorticoid class, they have distinct pharmacological profiles that may lead to different effects on various medical conditions. The lack of overlap in medical conditions discussed in both statements prevents any indirect support for the claim in question. + + + It is essential to consider that" +18495054,Hydrocortisone affects lymphoma,418,"Efficacy of methylprednisolone, cyclophosphamide in pediatric IgA nephropathy assessed by renal biopsy.",False,"Is the triple 'Hydrocortisone affects lymphoma' supported by the sentence: 'Efficacy of methylprednisolone, cyclophosphamide in pediatric IgA nephropathy assessed by renal biopsy.'?","No, the statement ""Efficacy of methylprednisolone, cyclophosphamide in pediatric IgA nephropathy assessed by renal biopsy"" does not provide indirect support for the claim that ""Hydrocortisone affects lymphoma"". + + The statement discusses the efficacy of methylprednisolone and cyclophosphamide in treating pediatric IgA nephropathy, which is a kidney disease. Hydrocortisone is another type of corticosteroid like methylprednisolone, but they have different chemical structures and properties. Lymphoma is a type of cancer that originates in the lymphatic system, not in the kidneys. + + Therefore, even though hydrocortisone is related to methylprednisolone (both being corticosteroids), the evidence provided does not pertain to hydrocortisone or its effects on lymphoma due to differences in treatment contexts (kidney disease vs lymphoma) as well as in the specific corticosteroids used in the study (methylprednisol" +18495053,Hydrocortisone affects leukemia,419,"The impaired effect on lymphocyte blastogenesis of glucocorticoids administered in vivo, in contrast to a normal in vitro reaction to dexamethasone, together with recent findings of an altered glucocorticoid receptor pharmacology in AD, points to a decreased biological in vivo efficiency of methylprednisolone in atopic dermatitis.",False,"Is the triple 'Hydrocortisone affects leukemia' supported by the sentence: 'The impaired effect on lymphocyte blastogenesis of glucocorticoids administered in vivo, in contrast to a normal in vitro reaction to dexamethasone, together with recent findings of an altered glucocorticoid receptor pharmacology in AD, points to a decreased biological in vivo efficiency of methylprednisolone in atopic dermatitis.'?","No, the statement does not provide direct or indirect support for the phrase ""Hydrocortisone affects leukemia."" The statement discusses the effects of glucocorticoids, specifically dexamethasone and methylprednisolone, on lymphocyte blastogenesis in atopic dermatitis (AD). Hydrocortisone is not mentioned in the statement at all; thus, it cannot provide support for any claim about hydrocortisone. + + However, even if hydrocortisone were mentioned in the statement, it would still not provide support for the claim that hydrocortisone affects leukemia because leukemia was not mentioned in the statement either. Leukemia is a specific type of cancer involving white blood cells, whereas atopic dermatitis is an inflammatory skin condition. The two conditions have different etiologies and pathophysiologies; thus, evidence from one condition does not necessarily translate to another condition. + + Therefore, based on the provided statement alone, it is not possible to conclude that hydrocortisone has any effect on leukemia. Additional evidence would be needed to" +18310128,Hydrocortisone affects toxic shock syndrome,420,"CONCLUSION: In this single-center trial, combined vasopressin-epinephrine and methylprednisolone during resuscitation and stress-dose hydrocortisone in postresuscitation shock improved survival in refractory in-hospital cardiac arrest.",True,"Is the triple 'Hydrocortisone affects toxic shock syndrome' supported by the sentence: 'CONCLUSION: In this single-center trial, combined vasopressin-epinephrine and methylprednisolone during resuscitation and stress-dose hydrocortisone in postresuscitation shock improved survival in refractory in-hospital cardiac arrest.'?","Yes, there is indirect support for the statement that ""hydrocortisone affects toxic shock syndrome"" based on the provided conclusion from a single-center trial. The conclusion suggests that hydrocortisone administration in postresuscitation shock improves survival rates in refractory in-hospital cardiac arrest patients who received vasopressin-epinephrine and methylprednisolone during resuscitation. + + + Although toxic shock syndrome is not explicitly mentioned in the conclusion, hydrocortisone has been used as an adjunctive treatment for toxic shock syndrome due to its anti-inflammatory properties (Slade et al., 2017). The evidence from this trial indirectly supports hydrocortisone's potential benefits in treating severe inflammatory conditions such as toxic shock syndrome by demonstrating its positive impact on survival rates in critically ill patients experiencing cardiac arrest. + + + However, it is essential to acknowledge that further investigation is required to establish a direct causal relationship between hydrocortisone administration and improvements in toxic shock syndrome specifically. The provided conclusion does not explicitly link hydrocortisone use to toxic shock syndrome but rather" +17910566,Hydrocortisone affects atopic eczema,421,Weekly bortezomib/methylprednisolone is effective and well tolerated in relapsed multiple myeloma.,False,Is the triple 'Hydrocortisone affects atopic eczema' supported by the sentence: 'Weekly bortezomib/methylprednisolone is effective and well tolerated in relapsed multiple myeloma.'?,"No, the statement ""Weekly bortezomib/methylprednisolone is effective and well tolerated in relapsed multiple myeloma"" does not provide indirect support for the claim that ""Hydrocortisone affects atopic eczema."" + + + The two statements discuss different medical conditions (atopic eczema vs multiple myeloma) and different medications (hydrocortisone vs bortezomib/methylprednisolone). The effectiveness of bortezomib/methylprednisolone in treating multiple myeloma does not imply that hydrocortisone would have any effect on atopic eczema. + + + The only potential connection between these two statements could be through methylprednisolone, which is a type of corticosteroid like hydrocortisone. Both medications can have immunosuppressive effects, but they have different potencies, durations of action, and routes of administration, which could lead to different therapeutic effects in different diseases like atopic eczema vs multiple myeloma. + + + Therefore, without further evidence connecting hydrocort" +15925719,Hydrocortisone affects Inflammation,422,Amsacrine combined with etoposide and high-dose methylprednisolone as salvage therapy in acute lymphoblastic leukemia in children.,False,Is the triple 'Hydrocortisone affects Inflammation' supported by the sentence: 'Amsacrine combined with etoposide and high-dose methylprednisolone as salvage therapy in acute lymphoblastic leukemia in children.'?,"No, the statement does not provide direct or indirect support for the phrase ""Hydrocortisone affects Inflammation."" The statement discusses a therapeutic approach using Amsacrine, etoposide, and high-dose methylprednisolone for treating acute lymphoblastic leukemia in children. Methylprednisolone is a type of corticosteroid similar to hydrocortisone; however, it does not necessarily imply that hydrocortisone has an effect on inflammation within the context provided. To establish support for that phrase, there would need to be specific evidence linking hydrocortisone to inflammation modulation." +14970164,Hydrocortisone affects Insulin resistance,423,Controlled clinical trial of IV cyclophosphamide versus IV methylprednisolone in severe neurological manifestations in systemic lupus erythematosus.,False,Is the triple 'Hydrocortisone affects Insulin resistance' supported by the sentence: 'Controlled clinical trial of IV cyclophosphamide versus IV methylprednisolone in severe neurological manifestations in systemic lupus erythematosus.'?,"No, the statement does not provide direct or indirect support for the phrase ""Hydrocortisone affects Insulin resistance."" The clinical trial mentioned in the statement compares two different treatments for severe neurological manifestations in systemic lupus erythematosus (SLE), one of which includes methylprednisolone, a corticosteroid like hydrocortisone. However, it does not provide any information on insulin resistance or how either treatment affects it. Insulin resistance is a condition in which cells do not respond properly to insulin, leading to high blood sugar levels. Hydrocortisone is known to have potential metabolic side effects such as increasing blood glucose levels, but its direct impact on insulin resistance remains an area for further investigation." +14804311,Hydrocortisone affects injury,424,Delayed hypersensitivity to 6-methyl-prednisolone in Henoch Schoenlein syndrome.,False,Is the triple 'Hydrocortisone affects injury' supported by the sentence: 'Delayed hypersensitivity to 6-methyl-prednisolone in Henoch Schoenlein syndrome.'?,"No, the statement ""Delayed hypersensitivity to 6-methyl-prednisolone in Henoch Schoenlein syndrome"" does not provide direct or indirect support for the phrase ""Hydrocortisone affects injury."" Hydrocortisone and 6-methyl-prednisolone are both glucocorticoids but they are different compounds with distinct properties. While the statement implies that glucocorticoids like 6-methyl-prednisolone may have an effect on immune response in Henoch Schoenlein syndrome, it does not provide evidence that hydrocortisone in particular influences injury. Further investigation into hydrocortisone-specific studies would be required for such validation." +14533429,Hydrocortisone affects hypotensive disorder,425,Rectal absorption of radioactive 6-alpha-methyl prednisolone in ulcerative colitis.,False,Is the triple 'Hydrocortisone affects hypotensive disorder' supported by the sentence: 'Rectal absorption of radioactive 6-alpha-methyl prednisolone in ulcerative colitis.'?,"No, the statement ""Rectal absorption of radioactive 6-alpha-methyl prednisolone in ulcerative colitis"" does not provide direct or indirect support for the claim that ""Hydrocortisone affects hypotensive disorder."" + + The reason is that these two statements refer to different corticosteroids (Hydrocortisone vs 6-alpha-methyl prednisolone) and different medical conditions (hypotensive disorder vs ulcerative colitis). The absorption of one steroid in treating ulcerative colitis does not inherently imply an effect on blood pressure regulation by another steroid. + + However, it is important to note that both hydrocortisone and 6-alpha-methyl prednisolone belong to the class of corticosteroids that can influence various physiological processes in the human body due to their anti-inflammatory properties. Nonetheless, specific experimental evidence would be required to establish any connection between hydrocortisone use and hypotensive disorder management." +13999195,Hydrocortisone affects congenital adrenal hyperplasia,426,Controlled trial of pulse methylprednisolone versus two regimens of pulse cyclophosphamide in severe lupus nephritis.,False,Is the triple 'Hydrocortisone affects congenital adrenal hyperplasia' supported by the sentence: 'Controlled trial of pulse methylprednisolone versus two regimens of pulse cyclophosphamide in severe lupus nephritis.'?,"No, the statement does not provide any direct or indirect support for the phrase ""Hydrocortisone affects congenital adrenal hyperplasia."" The study mentioned is focused on comparing pulse methylprednisolone with two regimens of pulse cyclophosphamide in treating severe lupus nephritis. Hydrocortisone is not mentioned in the study, nor is congenital adrenal hyperplasia (CAH) explicitly discussed. + + Although hydrocortisone is a glucocorticoid like methylprednisolone, which is used in the study, there is no mention of any specific interactions between these medications and congenital adrenal hyperplasia in humans or animal models. Thus, it is not possible to infer any support for that specific claim based on the provided statement alone. + + However, it is important to note that hydrocortisone has been used in treating congenital adrenal hyperplasia due to its glucocorticoid properties in managing adrenal insufficiency (Speiser et al., 2008). Nonetheless, the given statement does not provide any evidence for" +13347553,Hydrocortisone affects asthma,427,"The National Heart, Lung, and Blood Institute's ARDS Network currently is testing the use of methylprednisolone in late ARDS.",False,"Is the triple 'Hydrocortisone affects asthma' supported by the sentence: 'The National Heart, Lung, and Blood Institute's ARDS Network currently is testing the use of methylprednisolone in late ARDS.'?","No, the statement does not provide indirect support for the phrase ""Hydrocortisone affects asthma."" The National Heart, Lung, and Blood Institute's ARDS Network is testing methylprednisolone in late ARDS (Acute Respiratory Distress Syndrome), not hydrocortisone. Although methylprednisolone and hydrocortisone are both corticosteroids that can potentially influence inflammation and immune response in various conditions such as asthma and ARDS, they have distinct pharmacological properties, dosages, and therapeutic indications. + + The statement only implies that corticosteroids like methylprednisolone might have an effect on ARDS, but it does not necessarily extend that conclusion to hydrocortisone or asthma without additional information linking these specific components together. Therefore, it is essential to rely on direct evidence that specifically investigates hydrocortisone's impact on asthma when addressing that particular claim." +13180935,Hydrocortisone affects hypotensive disorder,428,"(3) Preliminary results of an interim analysis from an ongoing randomized, prospective study showed that methylprednisolone (plus an antiviral agent?) may be useful for improving peripheral vestibular function in vestibular neuritis.",False,"Is the triple 'Hydrocortisone affects hypotensive disorder' supported by the sentence: '(3) Preliminary results of an interim analysis from an ongoing randomized, prospective study showed that methylprednisolone (plus an antiviral agent?) may be useful for improving peripheral vestibular function in vestibular neuritis.'?","No, the statement does not provide direct or indirect support for the phrase ""Hydrocortisone affects hypotensive disorder."" The study refers to methylprednisolone, which is a glucocorticoid like hydrocortisone but not hydrocortisone itself. Additionally, the study focuses on vestibular neuritis and peripheral vestibular function, not hypotensive disorder." +11695335,Hydrocortisone affects Hypoxemia,429,This is the first report of cyclophosphamide and methylprednisolone leading to complete and sustained resolution of GAVE in association with systemic sclerosis.,False,Is the triple 'Hydrocortisone affects Hypoxemia' supported by the sentence: 'This is the first report of cyclophosphamide and methylprednisolone leading to complete and sustained resolution of GAVE in association with systemic sclerosis.'?,"No, the statement does not provide any direct or indirect support for the phrase ""Hydrocortisone affects Hypoxemia"". The statement discusses the effects of cyclophosphamide and methylprednisolone on gastrointestinal arterial vasospasm (GAVE) associated with systemic sclerosis. Hypoxemia is a condition characterized by low oxygen levels in the blood, while hydrocortisone is a type of steroid hormone often used for its anti-inflammatory effects. The two concepts are not connected in the given statement." +11304252,Hydrocortisone affects obesity disorder,430,We compared lymphocyte-suppressive potencies of prednisolone and methylprednisolone in rheumatoid arthritis (RA).,False,Is the triple 'Hydrocortisone affects obesity disorder' supported by the sentence: 'We compared lymphocyte-suppressive potencies of prednisolone and methylprednisolone in rheumatoid arthritis (RA).'?,"No, the statement does not provide direct or indirect support for the phrase ""Hydrocortisone affects obesity disorder"". The statement discusses a comparison of lymphocyte-suppressive potencies between prednisolone and methylprednisolone in rheumatoid arthritis (RA). Hydrocortisone is not mentioned in the statement; therefore, there is no basis for inferring any relationship between hydrocortisone and obesity disorder based on this statement alone. + + + To establish whether hydrocortisone affects obesity disorder, one would need specific studies that investigate any potential link between hydrocortisone use and obesity outcomes. Additionally, animal studies would need to be complemented by human studies for stronger evidence. The current statement does not provide any such information, making it impossible to draw any conclusions about hydrocortisone's effects on obesity disorder based on this statement alone." +10523644,Hydrocortisone affects injury,431,"Despite the lucrative ""off label"" markets for methylprednisolone in SCI, no Food and Drug Association indication has been obtained.",False,"Is the triple 'Hydrocortisone affects injury' supported by the sentence: 'Despite the lucrative ""off label"" markets for methylprednisolone in SCI, no Food and Drug Association indication has been obtained.'?","No, the statement does not provide indirect support for the phrase ""Hydrocortisone affects injury."" The statement discusses methylprednisolone use in spinal cord injuries (SCI) and its lack of Food and Drug Administration (FDA) indication despite lucrative off-label markets. Hydrocortisone is a different glucocorticoid than methylprednisolone, and no information is provided about its effects on injury in general or specifically on SCI. The two statements discuss different steroids in different contexts; therefore, no indirect support can be inferred for ""Hydrocortisone affects injury.""" +10431364,Hydrocortisone affects Inflammation,432,Extraocular muscle responses to high dose intravenous methylprednisolone in myasthenia gravis.,False,Is the triple 'Hydrocortisone affects Inflammation' supported by the sentence: 'Extraocular muscle responses to high dose intravenous methylprednisolone in myasthenia gravis.'?,"No, I would argue that the statement ""Extraocular muscle responses to high dose intravenous methylprednisolone in myasthenia gravis"" does not provide direct or indirect support for the claim ""Hydrocortisone affects Inflammation."" + + The reason is that methylprednisolone and hydrocortisone are both corticosteroids but they have different chemical structures and pharmacological properties. Methylprednisolone is primarily used as an anti-inflammatory drug, while hydrocortisone is used as an anti-inflammatory as well as a replacement for natural cortisol in patients with adrenal insufficiency. + + The statement in question discusses the effects of methylprednisolone on extraocular muscle responses in myasthenia gravis, which is an autoimmune disease characterized by muscle weakness. While both methylprednisolone and hydrocortisone have anti-inflammatory effects, they do not necessarily imply that hydrocortisone specifically affects inflammation in the same context as stated in the claim. + + To provide indirect support for the claim" +10074536,Hydrocortisone affects HIV infectious disease,433,The increased CSF levels of TNF-sRp55 in response to MP circumstantially suggest that this receptor could partially account for the beneficial effects of MP in acute MS.,False,Is the triple 'Hydrocortisone affects HIV infectious disease' supported by the sentence: 'The increased CSF levels of TNF-sRp55 in response to MP circumstantially suggest that this receptor could partially account for the beneficial effects of MP in acute MS.'?,"No, the statement does not provide indirect support for the phrase ""Hydrocortisone affects HIV infectious disease."" The statement discusses the potential role of microglial proliferation (MP) in multiple sclerosis (MS) and how hydrocortisone (CSF levels) might influence TNF-sRp55 receptors in that context. There is no mention or implication of HIV infectious disease in this statement." +9872405,Hydrocortisone affects toxic shock syndrome,434,"Such an effect has been demonstrated between clarithromycin and methylprednisolone, two drugs that may be administered concomitantly in asthma.",False,"Is the triple 'Hydrocortisone affects toxic shock syndrome' supported by the sentence: 'Such an effect has been demonstrated between clarithromycin and methylprednisolone, two drugs that may be administered concomitantly in asthma.'?","No, the statement does not provide indirect support for the claim that hydrocortisone affects toxic shock syndrome based on the provided context. The statement mentions an interaction between clarithromycin and methylprednisolone in asthma patients but does not mention hydrocortisone nor toxic shock syndrome. + + To establish indirect support for the claim, there should be some connection between hydrocortisone, toxic shock syndrome, and either clarithromycin or methylprednisolone in the statement. However, no such connection exists in the given context. + + Nevertheless, it is important to note that hydrocortisone is a glucocorticoid that can be used in treating toxic shock syndrome due to its anti-inflammatory properties; however, that does not imply that hydrocortisone has an effect on toxic shock syndrome itself but rather alleviates some symptoms by reducing inflammation." +9610203,Hydrocortisone affects neoplasm,435,"In this study, low-dose methylprednisolone (0.8 mg/kg/day, MP) was used to induce a steroid-resistant lupus nephritis (SR-LN) mouse model in weeks one to four, and a therapeutic steroid dosage (MP 12 mg/kg/day) or a combined PNS (PNS 100 mg/kg/day) treatment was administered from week five to eight.",False,"Is the triple 'Hydrocortisone affects neoplasm' supported by the sentence: 'In this study, low-dose methylprednisolone (0.8 mg/kg/day, MP) was used to induce a steroid-resistant lupus nephritis (SR-LN) mouse model in weeks one to four, and a therapeutic steroid dosage (MP 12 mg/kg/day) or a combined PNS (PNS 100 mg/kg/day) treatment was administered from week five to eight.'?","No, the statement does not provide direct or indirect support for the phrase ""Hydrocortisone affects neoplasm."" The study mentioned uses methylprednisolone (MP), not hydrocortisone, in a mouse model for lupus nephritis. A neoplasm refers to an abnormal growth of tissue, which is not addressed in the given context. Therefore, it is inappropriate to draw conclusions about hydrocortisone's effect on neoplasm based on this information alone." +9120606,Hydrocortisone affects asthma,436,MP was administrated in three alternative ways: intraperitoneally during the induction of cytotoxic edema or immediately after finishing cytotoxic edema induction in a dose of 100 mg/kg b.w.; into the internal carotid artery within 2 h after finishing cytotoxic edema induction in a dose of 50 mg/kg b.w.; into internal carotid artery 10 min after edema induction by BBBd in a dose of 50 mg/kg b.w.,False,Is the triple 'Hydrocortisone affects asthma' supported by the sentence: 'MP was administrated in three alternative ways: intraperitoneally during the induction of cytotoxic edema or immediately after finishing cytotoxic edema induction in a dose of 100 mg/kg b.w.; into the internal carotid artery within 2 h after finishing cytotoxic edema induction in a dose of 50 mg/kg b.w.; into internal carotid artery 10 min after edema induction by BBBd in a dose of 50 mg/kg b.w.'?,"No, the statement does not provide direct support for the phrase ""Hydrocortisone affects asthma."" The passage discusses the administration of MP (presumably an abbreviation for a different drug) in various ways in an experimental context related to cytotoxic edema induction. The text does not mention asthma or any related symptoms, making it impossible to infer any connection between hydrocortisone administration and asthma based on this information alone. + + + To provide further context, hydrocortisone is a type of corticosteroid often used in treating various medical conditions due to its potent anti-inflammatory effects. While some studies suggest that corticosteroids like hydrocortisone can benefit asthma patients by reducing inflammation in their airways, it would require separate evidence specifically linking hydrocortisone administration to improvements in asthma symptoms for the claim ""Hydrocortisone affects asthma"" to be supported. + + + In conclusion, while hydrocortisone has been studied in relation to asthma treatment, the provided" +8017440,Hydrocortisone affects obesity disorder,437,"On the other hand, daily administration of methylprednisolone and tenoxicam for 4 weeks caused increased inflammation and fibrosis and wasn't affective on protection of nerve physiomorphology.",False,"Is the triple 'Hydrocortisone affects obesity disorder' supported by the sentence: 'On the other hand, daily administration of methylprednisolone and tenoxicam for 4 weeks caused increased inflammation and fibrosis and wasn't affective on protection of nerve physiomorphology.'?","No, the statement does not provide indirect support for the phrase ""Hydrocortisone affects obesity disorder."" The statement discusses the effects of methylprednisolone and tenoxicam on inflammation and nerve physiomorphology after 4 weeks of daily administration. Hydrocortisone is not mentioned in the statement, nor is there any connection made to obesity disorder. Therefore, it is inappropriate to draw such conclusions based on this information alone. + + To provide indirect support for the statement ""Hydrocortisone affects obesity disorder,"" one would need evidence suggesting that hydrocortisone has some impact on obesity disorder, either positively (i.e., reducing inflammation associated with obesity) or negatively (i.e., exacerbating inflammation associated with obesity). The provided statement does not contain any information about hydrocortisone that could be used inferentially in relation to obesity disorder. + + It is essential to maintain rigorous standards when interpreting scientific evidence to avoid drawing false conclusions based on incomplete information. This helps ensure that subsequent actions based on these conclusions are well-informed" +7974249,Hydrocortisone affects Insulin resistance,438,Methylprednisolone was temporarily stopped while a broad work up for inflammatory and neoplastic causes was pursued.,False,Is the triple 'Hydrocortisone affects Insulin resistance' supported by the sentence: 'Methylprednisolone was temporarily stopped while a broad work up for inflammatory and neoplastic causes was pursued.'?,"No, the statement does not provide indirect support for the claim that hydrocortisone affects insulin resistance. The statement mentions methylprednisolone, which is a synthetic glucocorticoid similar to hydrocortisone in its therapeutic effects but is not identical in its mechanisms of action or metabolic side effects. Although both drugs can impact glucose metabolism and potentially contribute to insulin resistance indirectly through their anti-inflammatory properties, they have different chemical structures and pharmacological profiles that could lead to distinct effects on insulin sensitivity in vivo. + + To establish indirect support for the original claim, one should look for evidence that demonstrates similar glucocorticoid-induced metabolic consequences between methylprednisolone and hydrocortisone specifically in relation to insulin resistance. Additionally, it is essential to consider whether methylprednisolone was temporarily stopped due to its metabolic side effects on insulin resistance in particular as opposed to other potential adverse reactions. + + In summary, while both hydrocortisone and methylprednisolone belong to the glucocorticoid class of medications that can" +7366981,Hydrocortisone affects Hypoxemia,439,"Pneumocystis pneumonia induced by this dose of tacrolimus has been reported in many cases; however, we encountered a rare case of Pneumocystis pneumonia induced by low-dose tacrolimus and methylprednisolone.",False,"Is the triple 'Hydrocortisone affects Hypoxemia' supported by the sentence: 'Pneumocystis pneumonia induced by this dose of tacrolimus has been reported in many cases; however, we encountered a rare case of Pneumocystis pneumonia induced by low-dose tacrolimus and methylprednisolone.'?","No, the statement does not provide direct or indirect support for the phrase ""Hydrocortisone affects Hypoxemia"". The statement discusses Pneumocystis pneumonia induced by tacrolimus and methylprednisolone, but it does not mention hydrocortisone or hypoxemia. Hypoxemia refers to low oxygen levels in the blood, while hydrocortisone is a type of corticosteroid often used for its anti-inflammatory effects. The connection between these two concepts is not evident in the provided statement." +7266667,Hydrocortisone affects dissociative amnesia,440,The increased interval in the administration of MP resulted in slightly greater pain and an increased prevalence of NeP.,False,Is the triple 'Hydrocortisone affects dissociative amnesia' supported by the sentence: 'The increased interval in the administration of MP resulted in slightly greater pain and an increased prevalence of NeP.'?,"No, the statement does not provide indirect support for the phrase ""Hydrocortisone affects dissociative amnesia."" The statement discusses the effects of an increased interval in medication administration on pain and neuropathic pain prevalence (NeP). Hydrocortisone is not mentioned in the statement, making it irrelevant in establishing any connection between hydrocortisone use and dissociative amnesia." +27426083,Hydrocortisone produces HIV infectious disease,441,"We describe that high-dose methylprednisolone (20 mg/kg) can induce multifocal osteonecrosis (ON) in conjunction with thrombocytopenia, hypofibrinogenemia, and hyperlipemia.",False,"Is the triple 'Hydrocortisone produces HIV infectious disease' supported by the sentence: 'We describe that high-dose methylprednisolone (20 mg/kg) can induce multifocal osteonecrosis (ON) in conjunction with thrombocytopenia, hypofibrinogenemia, and hyperlipemia.'?","No, the statement does not provide indirect support for the phrase ""Hydrocortisone produces HIV infectious disease."" The statement discusses the side effects of high-dose methylprednisolone (20 mg/kg) treatment, including multifocal osteonecrosis (ON), thrombocytopenia, hypofibrinogenemia, and hyperlipemia. Hydrocortisone is another type of corticosteroid hormone like methylprednisolone, but there is no mention or implication in the statement connecting hydrocortisone to HIV infectious disease." +24427531,Hydrocortisone produces cirrhosis of liver,442,"OBJECTIVE: To report the third published case, as of April 8, 2006, of methylprednisolone-induced toxic hepatitis.",False,"Is the triple 'Hydrocortisone produces cirrhosis of liver' supported by the sentence: 'OBJECTIVE: To report the third published case, as of April 8, 2006, of methylprednisolone-induced toxic hepatitis.'?","No, the statement does not provide indirect support for the phrase ""Hydrocortisone produces cirrhosis of liver."" The objective in question discusses a case of methylprednisolone-induced toxic hepatitis. Methylprednisolone is not hydrocortisone; they are both glucocorticoids but different compounds with distinct pharmacological profiles. Hydrocortisone has not been mentioned or implicated in the statement, so there is no basis for inferring any association between hydrocortisone use and cirrhosis of the liver from this information alone." +23738730,Hydrocortisone produces congenital adrenal hyperplasia,443,"To our knowledge, this is the first discussion considering the possibility that the methylprednisolone recommended by NASCIS may cause acute corticosteroid myopathy.",False,"Is the triple 'Hydrocortisone produces congenital adrenal hyperplasia' supported by the sentence: 'To our knowledge, this is the first discussion considering the possibility that the methylprednisolone recommended by NASCIS may cause acute corticosteroid myopathy.'?","No, the statement does not provide indirect support for the phrase ""Hydrocortisone produces congenital adrenal hyperplasia"". + + The statement discusses methylprednisolone, which is a synthetic glucocorticoid used in various medical treatments including spinal cord injuries, as potentially causing acute corticosteroid myopathy. This is unrelated to hydrocortisone, which is a naturally occurring glucocorticoid produced by the adrenal gland, primarily involved in the regulation of metabolism, immune response, and stress response. + + Congenital adrenal hyperplasia (CAH) is a group of inherited genetic disorders affecting the adrenal glands and is not directly related to hydrocortisone administration. CAH is most commonly caused by mutations in genes encoding enzymes involved in cortisol synthesis leading to impaired cortisol production and excessive production of other steroid hormones. Hydrocortisone is sometimes used in treating CAH but does not cause it. + + Therefore, there is no indirect support for the claim that hydrocortisone produces congenital adrenal" +20514012,"Hydrocortisone produces dermatitis, atopic",444,"However, high-dose steroids like dexamethasone or methylprednisolone had proven their clearcut anti-tumoral action.",False,"Is the triple 'Hydrocortisone produces dermatitis, atopic' supported by the sentence: 'However, high-dose steroids like dexamethasone or methylprednisolone had proven their clearcut anti-tumoral action.'?","No, the statement does not provide indirect support for the phrase ""Hydrocortisone produces dermatitis, atopic."" In fact, it does not mention hydrocortisone at all. The statement discusses high-dose steroids like dexamethasone and methylprednisolone in relation to their anti-tumoral action. Hydrocortisone is structurally and functionally different from dexamethasone and methylprednisolone; it has lower glucocorticoid receptor binding affinity and is less potent than these synthetic steroids. Hydrocortisone is commonly associated with various side effects such as dermatitis; however, it also has anti-inflammatory properties that can be beneficial in certain clinical settings. Nonetheless, no link can be inferred from one statement about high-dose steroids to another statement about hydrocortisone-induced dermatitis based solely on their shared classification as steroids." +18924640,Hydrocortisone produces Inflammation,445,"Methylprednisolone increases some astrogliosis and inflammation biomarkers' levels; however, it did not affect the apoptotic biomarkers.",False,"Is the triple 'Hydrocortisone produces Inflammation' supported by the sentence: 'Methylprednisolone increases some astrogliosis and inflammation biomarkers' levels; however, it did not affect the apoptotic biomarkers.'?","No, the statement does not provide indirect support for the phrase ""Hydrocortisone produces Inflammation."" The statement discusses Methylprednisolone, not Hydrocortisone, and its effects on certain biomarkers related to inflammation and apoptosis (cell death). The lack of effect on apoptotic biomarkers does not imply an increase in inflammation. Furthermore, Hydrocortisone and Methylprednisolone are both glucocorticoids but have different pharmacological profiles, so inferences about one cannot be made based on studies involving the other without additional evidence supporting such a link." +16473285,Hydrocortisone produces type 1 diabetes mellitus,446,Effect of Methylprednisolone on Inflammation and Coagulation in Patients with Severe COVID-19: A Retrospective Cohort Study.,False,Is the triple 'Hydrocortisone produces type 1 diabetes mellitus' supported by the sentence: 'Effect of Methylprednisolone on Inflammation and Coagulation in Patients with Severe COVID-19: A Retrospective Cohort Study.'?,"No, the statement ""Effect of Methylprednisolone on Inflammation and Coagulation in Patients with Severe COVID-19: A Retrospective Cohort Study"" does not provide any direct or indirect support for the claim that ""Hydrocortisone produces type 1 diabetes mellitus."" The study focuses on Methylprednisolone (a glucocorticoid similar to Hydrocortisone) and its effects on inflammation and coagulation in patients with severe COVID-19, not on its potential in inducing type 1 diabetes mellitus. + + The two statements discuss different medical conditions (COVID-19 vs type 1 diabetes mellitus) and different glucocorticoids (Methylprednisolone vs Hydrocortisone). Thus, there is no link between them that would provide any evidence for the claim about Hydrocortisone causing type 1 diabetes mellitus. + + Furthermore, glucocorticoids like Hydrocortisone and Methylprednisolone can have various side-effects depending on factors such" +15760263,Hydrocortisone produces toxic shock syndrome,447,"METHODS/DESIGN: This study is a 12-week, randomised, double-blind, placebo-controlled trial analysing the effects of high-dose intravenous methylprednisolone in very early SSc.",False,"Is the triple 'Hydrocortisone produces toxic shock syndrome' supported by the sentence: 'METHODS/DESIGN: This study is a 12-week, randomised, double-blind, placebo-controlled trial analysing the effects of high-dose intravenous methylprednisolone in very early SSc.'?","No, the statement does not provide any indirect support for the phrase ""Hydrocortisone produces toxic shock syndrome."" The study mentioned in the statement is investigating the effects of high-dose intravenous methylprednisolone in very early systemic sclerosis (SSc), not hydrocortisone. Hydrocortisone, methylprednisolone, and other glucocorticoids can produce side effects such as toxic shock syndrome; however, it is essential to base conclusions on evidence specific to hydrocortisone rather than making inferences based on related compounds." +15330155,Hydrocortisone produces chronic primary adrenal insufficiency,448,"Methods: The potential interferences Se@SiO2 nanocomposites may have to the therapeutic effect of methylprednisolone (MPS) were evaluated by classical therapeutic effect index of acute respiratory distress syndrome (ARDS), such as wet-to-dry weight ratio, inflammatory factors IL-1beta and TNF-alpha.",False,"Is the triple 'Hydrocortisone produces chronic primary adrenal insufficiency' supported by the sentence: 'Methods: The potential interferences Se@SiO2 nanocomposites may have to the therapeutic effect of methylprednisolone (MPS) were evaluated by classical therapeutic effect index of acute respiratory distress syndrome (ARDS), such as wet-to-dry weight ratio, inflammatory factors IL-1beta and TNF-alpha.'?","No, the statement does not provide indirect support for the phrase ""Hydrocortisone produces chronic primary adrenal insufficiency."" The provided statement discusses an experiment where Se@SiO2 nanocomposites were evaluated for their potential interference with methylprednisolone (MPS) therapy in treating acute respiratory distress syndrome (ARDS). The therapeutic effect index was assessed using wet-to-dry weight ratio and inflammatory factors IL-1beta and TNF-alpha. Hydrocortisone is not mentioned in this context; therefore, no link can be established between hydrocortisone use and chronic primary adrenal insufficiency based on this information alone." +14100936,Hydrocortisone produces Insulin resistance,449,Our case likely represents worsening of DON due to soft tissue swelling secondary to OR despite cover with IVMP in a patient previously responsive to IVMP alone.,False,Is the triple 'Hydrocortisone produces Insulin resistance' supported by the sentence: 'Our case likely represents worsening of DON due to soft tissue swelling secondary to OR despite cover with IVMP in a patient previously responsive to IVMP alone.'?,"No, the statement does not provide indirect support for the phrase ""Hydrocortisone produces Insulin resistance."" The statement discusses a case likely representing worsening of DON (a condition known as Dexamethasone-induced Ocular Hypertension) due to soft tissue swelling secondary to OR (Oral Radiation) despite cover with IVMP (Intravenous Methylprednisolone) in a patient previously responsive to IVMP alone. This statement is about Dexamethasone-induced Ocular Hypertension and its worsening due to certain factors; it does not provide any evidence or mention hydrocortisone or insulin resistance. + + Insulin resistance refers to cells in the body becoming less responsive to insulin (a hormone produced in the pancreas), making it harder for glucose (sugar) in the bloodstream to enter cells and be used for energy. Hydrocortisone is a type of corticosteroid medication used primarily for its anti-inflammatory effects in various conditions such as allergic reactions, asthma, skin conditions, rheumatoid arthritis, and" +13891079,Hydrocortisone produces obesity disorder,450,[Treatment of invasive thymoma with myasthenia gravis: a case report responsive to azathioprine and methylprednisolone].,False,Is the triple 'Hydrocortisone produces obesity disorder' supported by the sentence: '[Treatment of invasive thymoma with myasthenia gravis: a case report responsive to azathioprine and methylprednisolone].'?,"No, the statement does not provide any direct or indirect support for the phrase ""Hydrocortisone produces obesity disorder."" The case report discusses the treatment of invasive thymoma with myasthenia gravis using azathioprine and methylprednisolone; however, it does not mention hydrocortisone as being responsible for producing obesity disorder in patients undergoing treatment. + + The study might have used methylprednisolone as part of its treatment regimen; methylprednisolone is a synthetic glucocorticoid similar to hydrocortisone in its therapeutic effects on inflammation. However, it does not follow that hydrocortisone would produce obesity disorder based on methylprednisolone use in this case report alone. + + Obesity is one potential side effect associated with long-term use and high doses of glucocorticoids like hydrocortisone; however, establishing causality between hydrocortisone use and obesity disorder would require further studies specifically designed to assess such an association in detail." +13796050,Hydrocortisone produces adrenal cortex neoplasm,451,High-dose intravenous methylprednisolone is the first-line therapy for acute exacerbations of NMO.,False,Is the triple 'Hydrocortisone produces adrenal cortex neoplasm' supported by the sentence: 'High-dose intravenous methylprednisolone is the first-line therapy for acute exacerbations of NMO.'?,"No, the statement ""High-dose intravenous methylprednisolone is the first-line therapy for acute exacerbations of NMO"" does not provide indirect support for the claim that ""Hydrocortisone produces adrenal cortex neoplasm."" + + The two statements discuss different aspects of corticosteroid treatment and neuroimmunological conditions. The first statement refers to methylprednisolone as a first-line therapy for Neuromyelitis Optica (NMO) exacerbations without mentioning hydrocortisone or adrenal cortex neoplasm (cancer). + + Hydrocortisone is another type of corticosteroid used in various medical treatments, while methylprednisolone is primarily used for its immunosuppressive effects. The development of adrenal cortex neoplasm due to hydrocortisone use is not mentioned as a potential side effect in either statement. + + Moreover, even if there were an association between hydrocortisone use and adrenal cortex neoplasm, it would not necessarily imply that hydrocortisone produces such neoplasms" +13783969,Hydrocortisone produces adrenocortical insufficiency,452,"CONCLUSION: Although the delayed administration of high-dose MP did not significantly increase the severity of pain or prevalence of NeP, it should still be avoided due to the increased risk of serious side effects.",False,"Is the triple 'Hydrocortisone produces adrenocortical insufficiency' supported by the sentence: 'CONCLUSION: Although the delayed administration of high-dose MP did not significantly increase the severity of pain or prevalence of NeP, it should still be avoided due to the increased risk of serious side effects.'?","No, the statement does not provide indirect support for the phrase ""Hydrocortisone produces adrenocortical insufficiency."" The conclusion is about administering high-dose methylprednisolone (MP), not hydrocortisone, and it mentions potential side effects without specifying which ones. Adrenocortical insufficiency is not mentioned in either statement; therefore, there is no connection between them that would allow for indirect support. + + The two statements refer to two different medications: hydrocortisone and methylprednisolone (MP). The conclusion is about MP, which is part of a class of drugs known as glucocorticoids that can have various side effects when used in high doses for extended periods. Adrenocortical insufficiency is not explicitly mentioned as one of these side effects in either statement; therefore, it cannot be inferred that hydrocortisone would produce adrenocortical insufficiency based on these statements alone. + + Additionally, it is essential to consider that any conclusions drawn from these statements should be supported by empirical evidence from well-designed studies that specifically investigate adrenocortical insufficiency as" +13669597,Hydrocortisone produces asthma,453,Methylprednisolone has been used in other Th1 mediated diseases such as rheumatoid arthritis in an attempt to switch off the immune response and so we investigated the efficacy of three days of high dose (1 g) intravenous methylprednisolone at the start of prednisolone therapy in leprosy Type 1 reactions and nerve function impairment.,False,Is the triple 'Hydrocortisone produces asthma' supported by the sentence: 'Methylprednisolone has been used in other Th1 mediated diseases such as rheumatoid arthritis in an attempt to switch off the immune response and so we investigated the efficacy of three days of high dose (1 g) intravenous methylprednisolone at the start of prednisolone therapy in leprosy Type 1 reactions and nerve function impairment.'?,"No, the statement does not provide any indirect support for the phrase ""Hydrocortisone produces asthma."" The statement discusses the use of methylprednisolone in rheumatoid arthritis and leprosy Type 1 reactions, but it does not mention hydrocortisone or asthma at all. Hydrocortisone and methylprednisolone are both corticosteroids used in treating various conditions, but they are not interchangeable in this context, and the effects of one cannot be inferred from the effects of the other. Furthermore, even if the statement had mentioned hydrocortisone, it would still not support the claim that hydrocortisone produces asthma, as it would be necessary to demonstrate a causal relationship between hydrocortisone use and asthma development for such support." +12147996,Hydrocortisone produces Sepsis,454,Myelitis in these patients was not related to graft versus host disease or immune reconstitution and was responsive to intravenous methylprednisolone and cyclophosphamide.,False,Is the triple 'Hydrocortisone produces Sepsis' supported by the sentence: 'Myelitis in these patients was not related to graft versus host disease or immune reconstitution and was responsive to intravenous methylprednisolone and cyclophosphamide.'?,"No, the statement does not provide any direct or indirect support for the phrase ""Hydrocortisone produces Sepsis."" In fact, it seems to suggest the opposite. The statement indicates that intravenous methylprednisolone, which is a type of corticosteroid similar to hydrocortisone, was used to treat myelitis in patients, implying that it was helpful in managing the condition rather than causing sepsis. Sepsis is a systemic inflammatory response to an infection, not typically a result of corticosteroid administration. However, it is important to note that corticosteroids can suppress the immune system, making individuals more susceptible to infections, which could potentially lead to sepsis in certain circumstances. But based on the information provided in the statement, there is no evidence to suggest that hydrocortisone produces sepsis." +11989948,Hydrocortisone produces Hypoxemia,455,"We investigated the effects of YM264, WEB2086, methylprednisolone and ticlopidine on puromycin-induced nephropathy in the rat.",False,"Is the triple 'Hydrocortisone produces Hypoxemia' supported by the sentence: 'We investigated the effects of YM264, WEB2086, methylprednisolone and ticlopidine on puromycin-induced nephropathy in the rat.'?","No, the statement does not provide any direct or indirect support for the claim that hydrocortisone produces hypoxemia (a condition characterized by low oxygen levels in the blood). The study investigates the effects of various compounds on puromycin-induced nephropathy in rats, which is an entirely different biological system and outcome than what would be expected in hydrocortisone-induced hypoxemia. + + + In order for this statement to provide indirect support for the claim, there would need to be some connection between the substances being investigated in the study (YM264, WEB2086, methylprednisolone, ticlopidine) and hydrocortisone-induced hypoxemia. Since no such connection is apparent in either the study design or outcomes reported in the statement provided, it is not reasonable to infer any support for that claim based on this evidence alone. + + + However, it is important to note that further investigation into potential links between these substances may reveal common mechanisms that could eventually be implicated in hypoxemia development; but based on the information provided in the question alone, no" +11730055,Hydrocortisone produces pneumonia,456,"The study strongly suggests that methylprednisolone has significant beneficial effects in human spinal cord injury, that these effects occur only when the drug is given within 8 hr, and that it helps even in patients with severe spinal cord injuries.",False,"Is the triple 'Hydrocortisone produces pneumonia' supported by the sentence: 'The study strongly suggests that methylprednisolone has significant beneficial effects in human spinal cord injury, that these effects occur only when the drug is given within 8 hr, and that it helps even in patients with severe spinal cord injuries.'?","No, the statement does not provide indirect support for the phrase ""Hydrocortisone produces pneumonia."" The study referenced in the statement investigates the effects of methylprednisolone on human spinal cord injury, not hydrocortisone. The two compounds have different chemical structures and pharmacological properties, meaning that any effects observed in one study may not be applicable or transferable to another compound without further investigation. + + Additionally, the statement highlights beneficial effects associated with methylprednisolone administration in spinal cord injury cases when given within 8 hours post-injury. This does not suggest any potential adverse effects related to methylprednisolone use, nor does it mention hydrocortisone at all. + + To establish any potential link between hydrocortisone use and pneumonia development, additional evidence would need to be provided that specifically investigates hydrocortisone's impact on respiratory health outcomes." +8328567,Hydrocortisone produces prostate cancer,457,"Comparison of the effects of 2 doses of methylprednisolone on pain, swelling, and trismus after third molar surgery.",False,"Is the triple 'Hydrocortisone produces prostate cancer' supported by the sentence: 'Comparison of the effects of 2 doses of methylprednisolone on pain, swelling, and trismus after third molar surgery.'?","No, the statement does not provide any direct or indirect support for the phrase ""Hydrocortisone produces prostate cancer."" The study mentioned in the statement is focused on comparing two doses of methylprednisolone (a glucocorticoid) on pain, swelling, and trismus after third molar surgery. Hydrocortisone is another type of glucocorticoid but is not mentioned or studied in this context; therefore, no conclusions can be drawn about its effects on prostate cancer from this statement." +8077250,Hydrocortisone produces neoplasm,458,Steatohepatitis during methylprednisolone therapy for ulcerative colitis exacerbation.,False,Is the triple 'Hydrocortisone produces neoplasm' supported by the sentence: 'Steatohepatitis during methylprednisolone therapy for ulcerative colitis exacerbation.'?,"No, the statement ""Steatohepatitis during methylprednisolone therapy for ulcerative colitis exacerbation"" does not provide indirect support for the claim that ""Hydrocortisone produces neoplasm."" + + + The reason is that methylprednisolone is not hydrocortisone. Although both are corticosteroids used in treating various medical conditions (including ulcerative colitis), they have different chemical structures and properties that may lead to distinct side effects. + + + Furthermore, while long-term use of corticosteroids has been associated with an increased risk for developing certain types of neoplasms (cancer), it is crucial to consider that correlation does not imply causation. Other factors may contribute to the development of neoplasms in patients undergoing corticosteroid therapy, such as genetic predisposition, lifestyle factors (e.g., smoking), or concomitant medication use. + + + Therefore, based on the provided statement alone, there is no solid ground for inferring that hydrocortisone specifically causes neoplasms. Nonetheless, it is essential to emphasize that long-term use" +27711985,Hydrocortisone disrupts adrenocortical insufficiency,459,These results suggest that increasing the uric acid concentration may represent one of the possible mechanisms of action of methylprednisolone in multiple sclerosis.,False,Is the triple 'Hydrocortisone disrupts adrenocortical insufficiency' supported by the sentence: 'These results suggest that increasing the uric acid concentration may represent one of the possible mechanisms of action of methylprednisolone in multiple sclerosis.'?,"No, the statement does not provide indirect support for the phrase ""Hydrocortisone disrupts adrenocortical insufficiency."" The initial statement discusses methylprednisolone in multiple sclerosis and its potential mechanism involving uric acid concentration increase. Hydrocortisone is another type of corticosteroid medication entirely distinct from methylprednisolone, and adrenocortical insufficiency is an unrelated medical condition. Therefore, there is no clear connection between these two ideas based on the information provided in the statement. + + To further clarify: + + - Hydrocortisone is a corticosteroid medication primarily used for adrenocortical insufficiency (Addison's disease) treatment because it replaces missing cortisol in patients suffering from insufficient adrenal gland function. + + - Methylprednisolone is another corticosteroid medication commonly used for its anti-inflammatory properties in various conditions like multiple sclerosis (MS) exacerbations. + + - The statement suggests that methylprednisolone may influence uric acid concentration as" +26428860,Hydrocortisone disrupts leukemia,460,"OBJECTIVE: Compare the therapeutic efficacy of an oral/metered-dose inhaler (oral/MDI) regimen to an intravenous/nebulizer (I.V./neb) regimen of methylprednisolone, cefuroxime, and inhaled albuterol and ipratropium bromide in patients hospitalized for exacerbations of chronic obstructive pulmonary disease (COPD).",False,"Is the triple 'Hydrocortisone disrupts leukemia' supported by the sentence: 'OBJECTIVE: Compare the therapeutic efficacy of an oral/metered-dose inhaler (oral/MDI) regimen to an intravenous/nebulizer (I.V./neb) regimen of methylprednisolone, cefuroxime, and inhaled albuterol and ipratropium bromide in patients hospitalized for exacerbations of chronic obstructive pulmonary disease (COPD).'?","No, the statement does not provide any direct or indirect support for the phrase ""Hydrocortisone disrupts leukemia."" The objective in question pertains to comparing the therapeutic efficacy of different drug regimens for COPD exacerbations in hospitalized patients. Hydrocortisone is not mentioned in the objective, nor is leukemia. The drugs mentioned in the objective (methylprednisolone, cefuroxime, albuterol, ipratropium bromide) have no direct association with hydrocortisone or leukemia in this context. + + However, hydrocortisone is a type of corticosteroid that can be used as an anti-inflammatory agent in treating various conditions such as leukemia. But since there is no mention of hydrocortisone or leukemia in the statement provided, it does not support the claim that hydrocortisone disrupts leukemia." +26389045,Hydrocortisone disrupts neoplasm,461,"Similar to the CRPS clinical response to glucocorticoids, we now demonstrate that chronic hindpaw edema in the sciatic transection CRPS model is reversed by a continuous infusion of MP (3 mg/kg/day over 21 days), and this anti-edematous effect persists for at least 1 week after discontinuing MP.",False,"Is the triple 'Hydrocortisone disrupts neoplasm' supported by the sentence: 'Similar to the CRPS clinical response to glucocorticoids, we now demonstrate that chronic hindpaw edema in the sciatic transection CRPS model is reversed by a continuous infusion of MP (3 mg/kg/day over 21 days), and this anti-edematous effect persists for at least 1 week after discontinuing MP.'?","No, the statement does not provide direct or indirect support for the phrase ""Hydrocortisone disrupts neoplasm."" The statement discusses an experiment where chronic hindpaw edema in a sciatic transection Complex Regional Pain Syndrome (CRPS) model is reversed by a continuous infusion of MP (a glucocorticoid). However, it does not mention hydrocortisone, another type of glucocorticoid, nor does it discuss neoplasms (abnormal tissue growths that can become cancerous). Therefore, there is no connection that can be inferred between hydrocortisone and disrupting neoplasms from this statement." +26128287,Hydrocortisone disrupts melanoma,462,STUDY OBJECTIVES: To assess whether IV methylprednisolone exerts a specific early effect on dyspnea in patients with an exacerbation of asthma.,False,Is the triple 'Hydrocortisone disrupts melanoma' supported by the sentence: 'STUDY OBJECTIVES: To assess whether IV methylprednisolone exerts a specific early effect on dyspnea in patients with an exacerbation of asthma.'?,"No, the statement does not provide indirect support for the phrase ""Hydrocortisone disrupts melanoma"". The study objective is assessing the effect of intravenous methylprednisolone on dyspnea in patients with asthma exacerbation. This investigation focuses on methylprednisolone and its impact on asthma symptoms; it does not involve hydrocortisone or melanoma in any capacity. To provide indirect support for ""Hydrocortisone disrupts melanoma"", there would need to be some mention or implication of hydrocortisone negatively affecting melanoma in either the study design, methodology, results, or conclusion; however, that is not evident in this particular study objective statement." +21020907,Hydrocortisone disrupts pneumonia,463,REVIEWER'S CONCLUSIONS: Cyclophosphamide regimen treatment is a form of care in neuropsychiatric involvement in systemic lupus erythematosus with no evidence to prove better effectiveness and safety when compared with methylprednisolone.,False,Is the triple 'Hydrocortisone disrupts pneumonia' supported by the sentence: 'REVIEWER'S CONCLUSIONS: Cyclophosphamide regimen treatment is a form of care in neuropsychiatric involvement in systemic lupus erythematosus with no evidence to prove better effectiveness and safety when compared with methylprednisolone.'?,"No, the statement does not provide indirect support for the phrase ""Hydrocortisone disrupts pneumonia."" The reviewer's conclusion focuses on comparing the effectiveness and safety between cyclophosphamide regimen treatment and methylprednisolone in neuropsychiatric involvement in systemic lupus erythematosus (SLE). Hydrocortisone is a type of corticosteroid like methylprednisolone, but the statement does not mention any connection between hydrocortisone and pneumonia disruption. + + However, it is important to note that corticosteroids like hydrocortisone and methylprednisolone can have immunosuppressive effects which might increase susceptibility to infections such as pneumonia if not properly managed. Nonetheless, based on the information provided in the reviewer's conclusion alone, there is no concrete evidence nor implicit connection supporting the claim that hydrocortisone disrupts pneumonia." +15895489,Hydrocortisone disrupts obesity disorder,464,"RESULTS: Both methylprednisolone and dexamethasone significantly reduced swelling and trismus (P < .05, Kruskal-Wallis test), whereas the methylprednisolone group had significantly less pain (P < .05, Kruskal-Wallis test) and consumed a lower amount of analgesics (P < .05, chi2 test) during the early postoperative days.",False,"Is the triple 'Hydrocortisone disrupts obesity disorder' supported by the sentence: 'RESULTS: Both methylprednisolone and dexamethasone significantly reduced swelling and trismus (P < .05, Kruskal-Wallis test), whereas the methylprednisolone group had significantly less pain (P < .05, Kruskal-Wallis test) and consumed a lower amount of analgesics (P < .05, chi2 test) during the early postoperative days.'?","No, the statement does not provide indirect support for the phrase ""Hydrocortisone disrupts obesity disorder."" The statement discusses results from a study involving methylprednisolone and dexamethasone, which are synthetic glucocorticoids used primarily for their anti-inflammatory effects. Hydrocortisone is also a glucocorticoid but has both glucocorticoid and mineralocorticoid activity. + + + The study results indicate that methylprednisolone and dexamethasone have an impact on swelling, trismus (a limited ability to open one's mouth), pain, and analgesic consumption in postoperative days; however, it does not provide evidence that hydrocortisone has any effect on obesity disorder. + + + The three glucocorticoids mentioned have different potencies and may have varying impacts on different physiological processes; therefore, it is not appropriate to generalize these study results to hydrocortisone's effect on obesity disorder without further investigation. + + + In summary, while these results may contribute to" +15750557,Hydrocortisone disrupts injury,465,Methylprednisolone only inhibited granulocytopenia and thrombocytopenia when zymosan-activated serum or fibrinogen-depleted plasma were infused.,False,Is the triple 'Hydrocortisone disrupts injury' supported by the sentence: 'Methylprednisolone only inhibited granulocytopenia and thrombocytopenia when zymosan-activated serum or fibrinogen-depleted plasma were infused.'?,"No, the statement does not provide indirect support for the phrase ""Hydrocortisone disrupts injury."" The statement discusses the effects of Methylprednisolone on granulocytopenia and thrombocytopenia when certain substances are infused, but it does not mention Hydrocortisone or provide any information about its potential impact on injury. Therefore, it does not offer any implicit or indirect evidence for the claim about Hydrocortisone disruption of injury." +8865955,Hydrocortisone disrupts Inflammation,466,"In addition, we detected that sufentanil provided prolonged pain relief up to 24 h when compared with control, whereas when we combined sufentanil plus methylprednisolone, we found that it further reduced pain and use of analgesics when compared with sufentanil.",False,"Is the triple 'Hydrocortisone disrupts Inflammation' supported by the sentence: 'In addition, we detected that sufentanil provided prolonged pain relief up to 24 h when compared with control, whereas when we combined sufentanil plus methylprednisolone, we found that it further reduced pain and use of analgesics when compared with sufentanil.'?","No, the statement does not provide direct or indirect support for the phrase ""Hydrocortisone disrupts Inflammation"". The statement discusses the effects of sufentanil and methylprednisolone on pain relief and use of analgesics, but it does not mention hydrocortisone or its impact on inflammation." +26205555,Hydrocortisone prevents neoplasm,467,These findings demonstrate that MP may suppress post-traumatic inflammatory reaction by inhibiting both the AP-1 and NF-kappaB transcription cascades via a GR mechanism.,False,Is the triple 'Hydrocortisone prevents neoplasm' supported by the sentence: 'These findings demonstrate that MP may suppress post-traumatic inflammatory reaction by inhibiting both the AP-1 and NF-kappaB transcription cascades via a GR mechanism.'?,"No, the statement does not provide direct or indirect support for the phrase ""Hydrocortisone prevents neoplasm."" The initial statement discusses how MP (presumably an abbreviation for a specific molecule or treatment) may suppress post-traumatic inflammatory reactions by inhibiting certain transcription cascades via a GR mechanism. While hydrocortisone is a type of glucocorticoid (GR) that has anti-inflammatory properties, it does not necessarily mean that hydrocortisone prevents neoplasms (abnormal growths that can lead to cancer). The provided statement focuses on inflammation rather than neoplasm prevention. Additionally, hydrocortisone's potential impact on neoplasm prevention would require separate evidence and investigation into its effects on cellular growth, differentiation, and apoptosis pathways related to neoplasm formation." +19342068,Hydrocortisone prevents obesity disorder,468,"This study assessed the effectiveness of a ganciclovir, methylprednisolone, and immunoglobulin combination (TAGMIC) therapy in decreasing cognitive impairment and mortality among patients with Japanese encephalitis.",False,"Is the triple 'Hydrocortisone prevents obesity disorder' supported by the sentence: 'This study assessed the effectiveness of a ganciclovir, methylprednisolone, and immunoglobulin combination (TAGMIC) therapy in decreasing cognitive impairment and mortality among patients with Japanese encephalitis.'?","No, the statement does not provide indirect support for the phrase ""Hydrocortisone prevents obesity disorder"". The study mentioned in the statement is focused on assessing the effectiveness of TAGMIC therapy in decreasing cognitive impairment and mortality among patients with Japanese encephalitis. Hydrocortisone is not mentioned in the study, nor is there any connection made between TAGMIC therapy and obesity disorder prevention." +19245686,Hydrocortisone prevents toxic shock syndrome,469,"From indirect comparisons, most interventions showed decreased risk of developing RA compared to placebo at 12 months, reaching statistical significance for methotrexate (OR 0.16 [95% CI 0.08, 0.33]) and intramuscular methylprednisolone (OR 0.72 [95% CI 0.53, 0.99]).",False,"Is the triple 'Hydrocortisone prevents toxic shock syndrome' supported by the sentence: 'From indirect comparisons, most interventions showed decreased risk of developing RA compared to placebo at 12 months, reaching statistical significance for methotrexate (OR 0.16 [95% CI 0.08, 0.33]) and intramuscular methylprednisolone (OR 0.72 [95% CI 0.53, 0.99]).'?","No, the statement does not provide indirect support for the claim that hydrocortisone prevents toxic shock syndrome. The statement discusses the effects of various interventions on reducing the risk of developing rheumatoid arthritis (RA) at 12 months. Hydrocortisone is not mentioned in the study, and intramuscular methylprednisolone is not equivalent to hydrocortisone in terms of its effects on toxic shock syndrome. + + The statement does provide evidence that intramuscular methylprednisolone may have some protective effects against RA development compared to placebo at 12 months (OR 0.72 [95% CI 0.53, 0.99]). However, hydrocortisone is not mentioned in the study as an intervention for RA nor as a preventative measure for toxic shock syndrome. Additionally, even if hydrocortisone were mentioned in relation to toxic shock syndrome in another study, it would not provide indirect support for the claim based on this statement alone because the contexts (RA vs toxic shock syndrome) and interventions (intramuscular methylprednisolone vs hydro" +18758297,Hydrocortisone prevents injury,470,Treatment with a pulse of methylprednisolone reduced both abdominal pain and lesion size.,False,Is the triple 'Hydrocortisone prevents injury' supported by the sentence: 'Treatment with a pulse of methylprednisolone reduced both abdominal pain and lesion size.'?,"No, the statement ""Treatment with a pulse of methylprednisolone reduced both abdominal pain and lesion size"" does not provide indirect support for the phrase ""Hydrocortisone prevents injury."" + + The primary reason for this is that methylprednisolone and hydrocortisone are two distinct glucocorticoids with different pharmacological properties and administration regimens. While they share some anti-inflammatory effects, they cannot be used interchangeably in all contexts due to their unique characteristics. + + Methylprednisolone is commonly used in high-dose ""pulse"" therapy for specific indications such as acute exacerbations in multiple sclerosis or severe asthma attacks due to its potent anti-inflammatory properties and relatively long duration of action compared to hydrocortisone. + + Hydrocortisone, on the other hand, is often used in lower doses for more prolonged periods in various clinical settings due to its shorter half-life and more rapid clearance from the body. + + Therefore, even if methylprednisolone demonstrates beneficial effects" +17956690,Hydrocortisone prevents Sepsis,471,Methylprednisolone prevents propranolol-induced airway hyperreactivity in the Basenji-greyhound dog.,False,Is the triple 'Hydrocortisone prevents Sepsis' supported by the sentence: 'Methylprednisolone prevents propranolol-induced airway hyperreactivity in the Basenji-greyhound dog.'?,"No, the statement ""Methylprednisolone prevents propranolol-induced airway hyperreactivity in the Basenji-greyhound dog"" does not provide indirect support for the claim that ""Hydrocortisone prevents Sepsis."" + + The reason for my decision is as follows: + + While both hydrocortisone and methylprednisolone are glucocorticoids used as anti-inflammatory agents in different medical contexts, they have distinct pharmacological profiles that may not translate directly from one application to another. The study involving methylprednisolone focuses on its ability to prevent propranolol-induced airway hyperreactivity in a specific canine breed, which is quite different from sepsis in humans - the condition that hydrocortisone is often used to prevent or treat. + + Sepsis is characterized by a dysregulated immune response leading to organ dysfunction and is often associated with infections caused by bacteria, viruses, or fungi. Hydrocortisone is thought to modulate immune function in sepsis by preventing excessive inflammation while maintaining adequate" +16963888,Hydrocortisone prevents adrenocortical insufficiency,472,Administration of methylprednisolone to prevent severe ovarian hyperstimulation syndrome in patients undergoing in vitro fertilization.,False,Is the triple 'Hydrocortisone prevents adrenocortical insufficiency' supported by the sentence: 'Administration of methylprednisolone to prevent severe ovarian hyperstimulation syndrome in patients undergoing in vitro fertilization.'?,"No, the statement does not provide direct or indirect support for the phrase ""Hydrocortisone prevents adrenocortical insufficiency."" Methylprednisolone is a synthetic glucocorticoid used in various clinical settings, including preventing severe ovarian hyperstimulation syndrome in patients undergoing in vitro fertilization. Hydrocortisone is also a glucocorticoid but has a different chemical structure and is primarily used in treating adrenocortical insufficiency by replacing deficient hormones in patients suffering from conditions like Addison's disease. + + The two statements mention different glucocorticoids being used for distinct medical indications; thus, they do not offer any support for the claim that hydrocortisone prevents adrenocortical insufficiency. However, understanding how various glucocorticoids work in different clinical situations may inform future studies on hydrocortisone use in adrenocortical insufficiency prevention or treatment." +15550113,Hydrocortisone prevents Inflammation,473,"Combined methylprednisolone, bupivacaine and morphine reduced pain, joint swelling, time of immobilization, duration of sick leave and return to sports after the arthroscopic procedure.",False,"Is the triple 'Hydrocortisone prevents Inflammation' supported by the sentence: 'Combined methylprednisolone, bupivacaine and morphine reduced pain, joint swelling, time of immobilization, duration of sick leave and return to sports after the arthroscopic procedure.'?","No, the statement does not provide direct or indirect support for the phrase ""Hydrocortisone prevents Inflammation."" The statement discusses the effects of combined methylprednisolone, bupivacaine, and morphine on pain, joint swelling, time of immobilization, duration of sick leave, and return to sports after an arthroscopic procedure. Methylprednisolone is a type of corticosteroid like hydrocortisone; however, it is not hydrocortisone itself, and the statement does not explicitly connect these treatments to inflammation prevention. + + To provide indirect support for ""Hydrocortisone prevents Inflammation,"" there would need to be evidence linking hydrocortisone specifically to inflammation prevention or some connection between methylprednisolone's effect on inflammation and hydrocortisone's potential effects on inflammation. Since no such connection is made in the statement provided, it does not offer support for the original phrase." +15540854,Hydrocortisone prevents pneumonia,474,Forty-eight patients who underwent bone marrow transplantation (BMT) from serologically HLA-matched unrelated donors received tacrolimus (FK506) alone or with methotrexate (MTX) and/or methylprednisolone (mPSL) to prevent graft-versus-host disease (GVHD).,False,Is the triple 'Hydrocortisone prevents pneumonia' supported by the sentence: 'Forty-eight patients who underwent bone marrow transplantation (BMT) from serologically HLA-matched unrelated donors received tacrolimus (FK506) alone or with methotrexate (MTX) and/or methylprednisolone (mPSL) to prevent graft-versus-host disease (GVHD).'?,"No, the statement does not provide indirect support for the claim that ""Hydrocortisone prevents pneumonia."" The statement discusses patients who underwent bone marrow transplantation (BMT) from serologically HLA-matched unrelated donors and received various medications (tacrolimus (FK506), methotrexate (MTX), methylprednisolone (mPSL)) as prophylaxis for graft-versus-host disease (GVHD). Hydrocortisone is not mentioned in the statement as one of these medications, so it does not offer any support for the claim about hydrocortisone preventing pneumonia. + + The statement instead focuses on medications used in preventing GVHD in patients who underwent BMT from unrelated donors. It does not discuss any potential effects these medications might have on pneumonia prevention nor does it mention hydrocortisone as one of these medications in question. Therefore, it is not reasonable to infer any indirect support for hydrocortisone preventing pneumonia from this statement alone." +14020540,Hydrocortisone prevents bronchopulmonary dysplasia,475,"Thus, calpeptin and methylprednisolone are found to be neuroprotective in SCI.",False,"Is the triple 'Hydrocortisone prevents bronchopulmonary dysplasia' supported by the sentence: 'Thus, calpeptin and methylprednisolone are found to be neuroprotective in SCI.'?","No, the statement does not provide indirect support for the phrase ""Hydrocortisone prevents bronchopulmonary dysplasia."" The two statements discuss different subjects: one focuses on neuroprotection in spinal cord injuries (SCI) using calpeptin and methylprednisolone, while the other addresses bronchopulmonary dysplasia prevention using hydrocortisone. + + To further clarify, let us analyze the components of each statement: + + - ""Thus, calpeptin and methylprednisolone are found to be neuroprotective in SCI."" This statement implies that calpeptin and methylprednisolone have protective effects on nerve cells in spinal cord injuries. + + - ""Hydrocortisone prevents bronchopulmonary dysplasia."" This statement suggests that hydrocortisone has the ability to prevent bronchopulmonary dysplasia, which is a chronic lung disease affecting premature infants. + + As both statements discuss different medical conditions and therapeutic agents, there is no indirect support linking hydrocortisone preventing bronchopulmonary dyspl" +13075196,Hydrocortisone prevents atrial fibrillation,476,"Methylprednisolone prevents the development of autotomy and neuropathic edema in rats, but has no effect on nociceptive thresholds.",False,"Is the triple 'Hydrocortisone prevents atrial fibrillation' supported by the sentence: 'Methylprednisolone prevents the development of autotomy and neuropathic edema in rats, but has no effect on nociceptive thresholds.'?","No, the statement does not provide indirect support for the phrase ""Hydrocortisone prevents atrial fibrillation."" The reason is that Methylprednisolone, not Hydrocortisone, is being tested in the experiment described in the statement. Furthermore, Methylprednisolone is shown to have an effect on autotomy and neuropathic edema in rats but not on nociceptive thresholds; atrial fibrillation is not addressed in any capacity in this statement. To provide indirect support for ""Hydrocortisone prevents atrial fibrillation,"" there would need to be some connection between methylprednisolone or its effects on rats and hydrocortisone or its effects on atrial fibrillation in humans; however, no such connection is evident in the statement provided." +12187318,Hydrocortisone prevents Insulin resistance,477,Chronically impaired renal function and the use of methylprednisolone may be the risk factors for SP.,False,Is the triple 'Hydrocortisone prevents Insulin resistance' supported by the sentence: 'Chronically impaired renal function and the use of methylprednisolone may be the risk factors for SP.'?,"No, the statement does not provide indirect support for the phrase ""Hydrocortisone prevents Insulin resistance."" The statement ""Chronically impaired renal function and the use of methylprednisolone may be the risk factors for SP"" is discussing factors that could potentially lead to secondary pulmonary hypertension (SP). Methylprednisolone is a type of corticosteroid like hydrocortisone, but it does not imply that hydrocortisone prevents insulin resistance. + + Insulin resistance is a condition where body cells do not respond properly to insulin, leading to high blood sugar levels. Hydrocortisone is known for its glucocorticoid activity, which can increase blood sugar levels by reducing insulin sensitivity in some cases. Therefore, it is unlikely that hydrocortisone prevents insulin resistance based on current knowledge. + + It is important to differentiate between discussing risk factors for developing certain conditions (SP) versus protective factors that prevent conditions (insulin resistance). The two statements provided here discuss different concepts related to different medical issues." +14643692,Hydrocortisone exacerbates Sepsis,478,"Because a common therapy for acute spinal cord injury is the use of an antiinflammatory synthetic glucocorticoid (methylprednisolone), we sought to determine mechanisms contributing to inflammation shortly after acute injury.",False,"Is the triple 'Hydrocortisone exacerbates Sepsis' supported by the sentence: 'Because a common therapy for acute spinal cord injury is the use of an antiinflammatory synthetic glucocorticoid (methylprednisolone), we sought to determine mechanisms contributing to inflammation shortly after acute injury.'?","No, the statement does not provide indirect support for the phrase ""Hydrocortisone exacerbates Sepsis."" The statement discusses the use of an anti-inflammatory synthetic glucocorticoid (methylprednisolone) in acute spinal cord injury and its contribution to inflammation shortly after injury. Hydrocortisone is also a glucocorticoid but is not mentioned in the statement as having any direct relation to sepsis mechanisms. + + To establish indirect support for ""Hydrocortisone exacerbates Sepsis,"" there would need to be some connection between hydrocortisone use and increased sepsis risk or severity in either experimental results or prior literature discussed in context. Since neither is mentioned in the statement provided, it does not offer indirect support for that particular claim about hydrocortisone and sepsis." +8122784,Hydrocortisone exacerbates obesity disorder,479,"Combined treatments of rG-CSF with cefotaxime, cefazolin, fosfomycin, gentamicin or amphotericin B were evaluated in systemic infections with Pseudomonas aeruginosa, Escherichia coli, Serratia marcescens, Staphylococcus aureus and Candida albicans in leucopenic mice induced by pretreatment with cyclophosphamide.",False,"Is the triple 'Hydrocortisone exacerbates obesity disorder' supported by the sentence: 'Combined treatments of rG-CSF with cefotaxime, cefazolin, fosfomycin, gentamicin or amphotericin B were evaluated in systemic infections with Pseudomonas aeruginosa, Escherichia coli, Serratia marcescens, Staphylococcus aureus and Candida albicans in leucopenic mice induced by pretreatment with cyclophosphamide.'?","No, the statement does not provide indirect support for the phrase ""Hydrocortisone exacerbates obesity disorder"". The statement discusses the evaluation of combined treatments using various antibiotics and amphotericin B in systemic infections caused by several bacterial and fungal strains in leucopenic mice induced by cyclophosphamide pretreatment. There is no mention or implication of hydrocortisone, obesity, or any obesity-related disorders in the statement." +25411585,Hydrocortisone predisposes atrial fibrillation,480,"One such marker, CTX-M-15, expressed by Enterobacteriaceae produces beta-lactamases, which hydrolyze the cephalosporin group of antibiotics, such as cefotaxime, used in the treatment of both Gram-positive and negative bacterial infections.",False,"Is the triple 'Hydrocortisone predisposes atrial fibrillation' supported by the sentence: 'One such marker, CTX-M-15, expressed by Enterobacteriaceae produces beta-lactamases, which hydrolyze the cephalosporin group of antibiotics, such as cefotaxime, used in the treatment of both Gram-positive and negative bacterial infections.'?","No, the statement does not provide indirect support for the phrase ""Hydrocortisone predisposes atrial fibrillation."" The statement discusses the relationship between CTX-M-15 (a type of beta-lactamase) produced by Enterobacteriaceae and its ability to hydrolyze cephalosporin antibiotics like cefotaxime. This information is related to bacterial infections and antibiotic resistance rather than hydrocortisone and atrial fibrillation. + + Atrial fibrillation is an irregular heart rhythm (arrhythmia), while hydrocortisone is a type of steroid hormone often used in anti-inflammatory treatments. Although there may be various factors contributing to atrial fibrillation development, there is no clear connection between hydrocortisone usage and atrial fibrillation based on the provided statement. + + To establish such indirect support, there would need to be some link between hydrocortisone usage and atrial fibrillation risk markers (such as CTX-M-15 in the statement) in the context presented; however, no" +19755964,Hydrocortisone predisposes Sepsis,481,"CONS, Staphylococcus aureus, Enterococci, Escherichia coli, Klebsiella and Enterobacter represented 91.9% of LOS episodes and were susceptible to vancomycin and cefotaxime (96.1%), vancomycin and gentamicin (97.0%) and cloxacillin and gentamicin (38.1%).",False,"Is the triple 'Hydrocortisone predisposes Sepsis' supported by the sentence: 'CONS, Staphylococcus aureus, Enterococci, Escherichia coli, Klebsiella and Enterobacter represented 91.9% of LOS episodes and were susceptible to vancomycin and cefotaxime (96.1%), vancomycin and gentamicin (97.0%) and cloxacillin and gentamicin (38.1%).'?","No, the statement does not provide indirect support for the phrase ""Hydrocortisone predisposes Sepsis."" The statement discusses antibiotic susceptibility patterns in certain bacterial species that frequently cause hospital-acquired infections (Los episodes). It does not mention hydrocortisone or sepsis at all. Sepsis is a complex condition that involves an overwhelming immune response to an infection, which can be caused by various microorganisms, not only those listed in the statement. Hydrocortisone is a glucocorticoid hormone that has anti-inflammatory effects and is sometimes used in treating sepsis; however, its use does not automatically predispose someone to sepsis as it has both beneficial and potentially harmful effects depending on the context in which it is used." +13712588,Hydrocortisone predisposes injury,482,"The protective effect of cefotaxime, aztreonam and gentamicin in peritonitis induced by E. coli alone or combined with B. fragilis was evaluated by analysing mortality at 24 and 48 h after bacterial inoculation and treating the animals with two doses of each antibiotic.",False,"Is the triple 'Hydrocortisone predisposes injury' supported by the sentence: 'The protective effect of cefotaxime, aztreonam and gentamicin in peritonitis induced by E. coli alone or combined with B. fragilis was evaluated by analysing mortality at 24 and 48 h after bacterial inoculation and treating the animals with two doses of each antibiotic.'?","No, the statement does not provide indirect support for the phrase ""Hydrocortisone predisposes injury."" The statement discusses an experiment where three antibiotics were tested for their protective effect against peritonitis induced by Escherichia coli (E. coli) alone or combined with Bacteroides fragilis in animals. There is no mention or implication of hydrocortisone in this experiment or its potential involvement in predisposing injury." +12555774,Hydrocortisone predisposes toxic shock syndrome,483,"HR 810 had more potent protective effect than ceftazidime (CAZ), cefoperazone (CPZ), and cefotaxime (CTX) on systemic infections induced by Escherichia coli Ec-31, Staphylococcus aureus SMITH, and Serratia marcescens Sm-6 in mice.",False,"Is the triple 'Hydrocortisone predisposes toxic shock syndrome' supported by the sentence: 'HR 810 had more potent protective effect than ceftazidime (CAZ), cefoperazone (CPZ), and cefotaxime (CTX) on systemic infections induced by Escherichia coli Ec-31, Staphylococcus aureus SMITH, and Serratia marcescens Sm-6 in mice.'?","No, the statement does not provide direct or indirect support for the phrase ""Hydrocortisone predisposes toxic shock syndrome."" The statement discusses the efficacy of various antibiotics in protecting mice from systemic infections caused by certain bacteria. Hydrocortisone is not mentioned in this statement, nor is there any information linking it to toxic shock syndrome. Therefore, it is not possible to make any conclusions about the relationship between hydrocortisone and toxic shock syndrome based on this statement alone." +11782928,Hydrocortisone predisposes Inflammation,484,"1,480 patients, undergoing elective orthopedic and traumatic surgery, received intragluteal injections of ceftriaxone (Rocephin) to prevent bacterial infections.",False,"Is the triple 'Hydrocortisone predisposes Inflammation' supported by the sentence: '1,480 patients, undergoing elective orthopedic and traumatic surgery, received intragluteal injections of ceftriaxone (Rocephin) to prevent bacterial infections.'?","No, the statement does not provide any direct or indirect support for the phrase ""Hydrocortisone predisposes Inflammation"". The statement mentions that patients received ceftriaxone (Rocephin) injections for preventing bacterial infections during surgery; however, it does not mention hydrocortisone or inflammation at all. To evaluate whether hydrocortisone predisposes inflammation, we would need evidence related specifically to hydrocortisone use and its impact on inflammation." +10520517,Hydrocortisone predisposes obesity disorder,485,Proceedings: A double blind trial of carbenoxolone and geranyl farnesylacetate in gastric ulcer.,False,Is the triple 'Hydrocortisone predisposes obesity disorder' supported by the sentence: 'Proceedings: A double blind trial of carbenoxolone and geranyl farnesylacetate in gastric ulcer.'?,"No, the statement ""Proceedings: A double blind trial of carbenoxolone and geranyl farnesylacetate in gastric ulcer"" does not provide indirect support for the phrase ""Hydrocortisone predisposes obesity disorder."" + + The statement is about a double-blind trial involving carbenoxolone and geranyl farnesylacetate in treating gastric ulcers. There is no mention or implication of hydrocortisone, obesity disorder, or any connection between them in this statement. Hydrocortisone is a steroid hormone often used in medication for various conditions such as inflammation, allergies, and skin disorders; it is not mentioned in the given statement. Therefore, it does not offer any indirect support for the claim about hydrocortisone predisposing obesity disorder." +8615556,Hydrocortisone predisposes dissociative amnesia,486,A controlled double-blind study was performed in 17 institutes using gefarnate as a control drug in order to investigate the therapeutic effect and safety of pirenzepine dihydrochloride (LS 519) in duodenal ulcer.,False,Is the triple 'Hydrocortisone predisposes dissociative amnesia' supported by the sentence: 'A controlled double-blind study was performed in 17 institutes using gefarnate as a control drug in order to investigate the therapeutic effect and safety of pirenzepine dihydrochloride (LS 519) in duodenal ulcer.'?,"No, the statement does not provide any direct or indirect support for the claim that ""Hydrocortisone predisposes dissociative amnesia."" The study mentioned is investigating the therapeutic effect and safety of pirenzepine dihydrochloride (LS 519) in duodenal ulcer using gefarnate as a control drug. Hydrocortisone is not mentioned in this statement, nor is there any information linking it to dissociative amnesia. Therefore, it is not appropriate to draw such conclusions based on this information alone." +8552834,Hydrocortisone predisposes asthma,487,Gefarnate at 300 mg/kg (p.o.) significantly inhibited phenylbutazone-induced gastric ulcers in rats but had no effect on other ulcer models.,False,Is the triple 'Hydrocortisone predisposes asthma' supported by the sentence: 'Gefarnate at 300 mg/kg (p.o.) significantly inhibited phenylbutazone-induced gastric ulcers in rats but had no effect on other ulcer models.'?,"No, the statement does not provide any indirect support for the phrase ""Hydrocortisone predisposes asthma."" The two statements discuss different subjects: one is about hydrocortisone potentially predisposing individuals to asthma, while the other is about gefarnate inhibiting phenylbutazone-induced gastric ulcers in rats without affecting other ulcer models. There is no overlap in content between these two statements that would allow for inferring support for the claim about hydrocortisone and asthma." +8002300,Hydrocortisone predisposes Insulin resistance,488,We tested streptomycin (ST) and neomycin (NEO) as analgesic agents applied in situ in rat paw inflammation caused by formalin or carrageenan administration.,False,Is the triple 'Hydrocortisone predisposes Insulin resistance' supported by the sentence: 'We tested streptomycin (ST) and neomycin (NEO) as analgesic agents applied in situ in rat paw inflammation caused by formalin or carrageenan administration.'?,"No, the statement does not provide any direct or indirect support for the phrase ""Hydrocortisone predisposes Insulin resistance"". The experiment tested streptomycin (ST) and neomycin (NEO) as analgesic agents in rat paw inflammation caused by formalin or carrageenan administration. There is no mention of hydrocortisone, insulin resistance, or any related conditions in the statement. Therefore, it is not possible to draw any conclusions about the relationship between hydrocortisone and insulin resistance based on this information alone." +7960726,Hydrocortisone predisposes pneumonia,489,[ON THE ACTION OF A NEOMYCIN AND THIOPENICOL PREPARATION IN EXPERIMENTAL BURNS].,False,Is the triple 'Hydrocortisone predisposes pneumonia' supported by the sentence: '[ON THE ACTION OF A NEOMYCIN AND THIOPENICOL PREPARATION IN EXPERIMENTAL BURNS].'?,"No, the statement ""Hydrocortisone predisposes pneumonia"" does not receive indirect support from the provided statement: ""[ON THE ACTION OF A NEOMYCIN AND THIOPENICOL PREPARATION IN EXPERIMENTAL BURNS]"". + + The provided statement is about an experimental study on burns using a neomycin and thiopencil preparation, which does not mention hydrocortisone or pneumonia at all. Indirect support would require some connection between the two pieces of information, but in this case, there is no such connection. Therefore, it is not appropriate to infer that hydrocortisone predisposes pneumonia based on this statement alone." +27228384,Methylprednisolone related to Crohn disease,490,"Therefore, we investigated the effect of long-term exposure of an antibiotic cocktail composed of Vancomycin, Neomycin, and Streptomycin, on tumor development and progression in the ApcMin/+ mouse, an established genetic model for familial adenomatous polyposis.",False,"Is the triple 'Methylprednisolone related to Crohn disease' supported by the sentence: 'Therefore, we investigated the effect of long-term exposure of an antibiotic cocktail composed of Vancomycin, Neomycin, and Streptomycin, on tumor development and progression in the ApcMin/+ mouse, an established genetic model for familial adenomatous polyposis.'?","No, the statement does not provide indirect support for the phrase ""Methylprednisolone related to Crohn disease."" The statement discusses an investigation into the effect of long-term exposure to an antibiotic cocktail on tumor development and progression in a specific mouse model for familial adenomatous polyposis. Methylprednisolone is a corticosteroid used primarily for its anti-inflammatory effects in various diseases such as Crohn disease; however, it is not mentioned nor implied in the provided statement. Therefore, it is not reasonable to infer any connection between methylprednisolone and Crohn disease based on this information alone." +26974005,Methylprednisolone related to hematopoietic and lymphoid system neoplasm,491,Ultrahigh doses of gentamicin and clinically relevant doses of neomycin affect inflammation and angiogenesis in in vivo and in vitro models.,False,Is the triple 'Methylprednisolone related to hematopoietic and lymphoid system neoplasm' supported by the sentence: 'Ultrahigh doses of gentamicin and clinically relevant doses of neomycin affect inflammation and angiogenesis in in vivo and in vitro models.'?,"No, the statement does not provide indirect support for the phrase ""Methylprednisolone related to hematopoietic and lymphoid system neoplasm."" The statement discusses the effects of ultrahigh doses of gentamicin and clinically relevant doses of neomycin on inflammation and angiogenesis in in vivo and in vitro models. Methylprednisolone is not mentioned in the statement, nor is there any connection made between these antibiotics and hematopoietic and lymphoid system neoplasms (a type of cancer). Therefore, it is not possible to infer any relationship between methylprednisolone and hematopoietic and lymphoid system neoplasms based on this information alone." +26513818,Methylprednisolone related to B-cell chronic lymphocytic leukemia,492,"Biodegradable polyaspartamide (PASPAM) was grafted with several functional groups to implement diverse roles-octadecylamine (C 18 ) for nano-aggregate formation, dopamine (DOPA) for adhesive function, neomycin (NEO) for inhibition of bacterial infection.",False,"Is the triple 'Methylprednisolone related to B-cell chronic lymphocytic leukemia' supported by the sentence: 'Biodegradable polyaspartamide (PASPAM) was grafted with several functional groups to implement diverse roles-octadecylamine (C 18 ) for nano-aggregate formation, dopamine (DOPA) for adhesive function, neomycin (NEO) for inhibition of bacterial infection.'?","No, there is no direct or indirect support for the phrase ""Methylprednisolone related to B-cell chronic lymphocytic leukemia"" in the statement provided. The statement discusses the grafting of functional groups onto biodegradable polyaspartamide (PASPAM) for various roles, but it does not mention methylprednisolone or B-cell chronic lymphocytic leukemia at all. Methylprednisolone is a corticosteroid medication used for various conditions like allergies, arthritis, and other inflammatory diseases; it is not mentioned in the context of B-cell chronic lymphocytic leukemia in this statement." +26050805,Methylprednisolone related to ankylosing spondylitis,493,Kaposi's sarcoma-associated herpesvirus-positive primary effusion lymphoma tumor formation in NOD/SCID mice is inhibited by neomycin and neamine blocking angiogenin's nuclear translocation.,False,Is the triple 'Methylprednisolone related to ankylosing spondylitis' supported by the sentence: 'Kaposi's sarcoma-associated herpesvirus-positive primary effusion lymphoma tumor formation in NOD/SCID mice is inhibited by neomycin and neamine blocking angiogenin's nuclear translocation.'?,"No, the statement does not provide indirect support for the phrase ""Methylprednisolone related to ankylosing spondylitis."" The statement discusses Kaposi's sarcoma-associated herpesvirus-positive primary effusion lymphoma tumor formation in NOD/SCID mice and its inhibition by neomycin and neamine blocking angiogenin's nuclear translocation. There is no mention or implication of methylprednisolone or ankylosing spondylitis in the statement. Methylprednisolone is a corticosteroid used for its anti-inflammatory effects, while ankylosing spondylitis is a type of arthritis affecting the spine; neither is related to the Kaposi's sarcoma-associated herpesvirus or angiogenin mentioned in the statement." +25845844,Methylprednisolone related to breast neoplasm,494,Neomycin and the combination of neomycin and bacitracin in the prevention of bacterial infection in surgery of the colon and/or rectum.,False,Is the triple 'Methylprednisolone related to breast neoplasm' supported by the sentence: 'Neomycin and the combination of neomycin and bacitracin in the prevention of bacterial infection in surgery of the colon and/or rectum.'?,"No, the statement does not provide indirect support for the phrase ""Methylprednisolone related to breast neoplasm."" The two statements discuss different topics: one is about antibiotics (neomycin and bacitracin) used in surgery for colon/rectum infections, while the other is about Methylprednisolone potentially being related to breast neoplasm (tumor). There is no connection between these two ideas in terms of content, context, or implied relationships." +25642837,Methylprednisolone related to dermatomyositis,495,Results of salvage therapy with mini-hyper-CVD and inotuzumab ozogamicin with or without blinatumomab in pre-B acute lymphoblastic leukemia.,False,Is the triple 'Methylprednisolone related to dermatomyositis' supported by the sentence: 'Results of salvage therapy with mini-hyper-CVD and inotuzumab ozogamicin with or without blinatumomab in pre-B acute lymphoblastic leukemia.'?,"No, the statement does not provide any direct or indirect support for the phrase ""Methylprednisolone related to dermatomyositis."" The statement discusses salvage therapy for pre-B acute lymphoblastic leukemia using mini-hyper-CVD, inotuzumab ozogamicin, and blinatumomab, but it does not mention methylprednisolone or dermatomyositis. Therefore, there is no connection that can be inferred from this statement." +25328503,Methylprednisolone related to Meniere disease,496,"The impressive clinical success of the continuously intravenously infused T cell-redirecting bispecific antibody (T-bsAb) blinatumomab (anti-CD19 x anti-CD3), and of engineered T cells expressing anti-CD19 chimeric antigen receptors (CAR-T cells) in hematological malignancies, has led to renewed interest in a novel cancer immunotherapy strategy that combines features of antibody- and cell-based therapies.",False,"Is the triple 'Methylprednisolone related to Meniere disease' supported by the sentence: 'The impressive clinical success of the continuously intravenously infused T cell-redirecting bispecific antibody (T-bsAb) blinatumomab (anti-CD19 x anti-CD3), and of engineered T cells expressing anti-CD19 chimeric antigen receptors (CAR-T cells) in hematological malignancies, has led to renewed interest in a novel cancer immunotherapy strategy that combines features of antibody- and cell-based therapies.'?","No, the statement does not provide indirect support for the phrase ""Methylprednisolone related to Meniere disease."" The statement discusses advancements in cancer immunotherapy using T cell-redirecting bispecific antibodies (T-bsAb) and chimeric antigen receptor (CAR) T cells in hematological malignancies, but it does not mention Methylprednisolone nor Meniere disease. Methylprednisolone is a corticosteroid commonly used for its anti-inflammatory effects in various conditions, while Meniere disease is an inner ear disorder characterized by vertigo, tinnitus, hearing loss, and pressure in the affected ear. Although both Methylprednisolone and cancer immunotherapy can be relevant in treating certain medical conditions, they are not inherently related in this context." +24759961,Methylprednisolone related to non-Hodgkin lymphoma,497,Blinatumomab and inotuzumab ozogamycin represent promising alternatives to conventional chemotherapy in acute lymphoblastic leukaemia (ALL).,False,Is the triple 'Methylprednisolone related to non-Hodgkin lymphoma' supported by the sentence: 'Blinatumomab and inotuzumab ozogamycin represent promising alternatives to conventional chemotherapy in acute lymphoblastic leukaemia (ALL).'?,"No, the statement ""Blinatumomab and inotuzumab ozogamycin represent promising alternatives to conventional chemotherapy in acute lymphoblastic leukaemia (ALL)"" does not provide indirect support for the phrase ""Methylprednisolone related to non-Hodgkin lymphoma."" + + The statement discusses two promising treatments for acute lymphoblastic leukaemia (ALL), blinatumomab and inotuzumab ozogamycin, as alternatives to conventional chemotherapy. Methylprednisolone is not mentioned in this statement nor is it implied in any way as being related to non-Hodgkin lymphoma. + + Non-Hodgkin lymphoma is a type of cancer that starts in white blood cells called lymphocytes, which are part of the body's immune system. It is distinct from acute lymphoblastic leukaemia (ALL), which is a rapidly progressing cancer that starts from early forms of white blood cells in bone marrow called lymphoblasts. + + Methyl" +24691450,Methylprednisolone related to plantar fasciitis,498,Efficacy of ciprofloxacin and dexamethasone in experimental pseudomonas endophthalmitis.,False,Is the triple 'Methylprednisolone related to plantar fasciitis' supported by the sentence: 'Efficacy of ciprofloxacin and dexamethasone in experimental pseudomonas endophthalmitis.'?,"No, the statement ""Efficacy of ciprofloxacin and dexamethasone in experimental pseudomonas endophthalmitis"" does not provide indirect support for the phrase ""Methylprednisolone related to plantar fasciitis."" The statement discusses the efficacy of ciprofloxacin and dexamethasone in treating experimental pseudomonas endophthalmitis, an eye condition. Methylprednisolone is not mentioned in the statement nor is it related to ciprofloxacin, dexamethasone, or pseudomonas endophthalmitis in any way that would suggest an indirect link to plantar fasciitis. + + Plantar fasciitis is a foot condition that involves inflammation of the plantar fascia tissue, while methylprednisolone is a type of corticosteroid used for its anti-inflammatory properties in various medical conditions. The lack of any direct or indirect connection between methylprednisolone and plantar fasciitis in the provided statement necessitates a negative response to the question." +24586108,Methylprednisolone related to alcoholic hepatitis,499,CONCLUSIONS: Combination therapy of adalimumab and ciprofloxacin is more effective than adalimumab monotherapy to achieve fistula closure in CD.,False,Is the triple 'Methylprednisolone related to alcoholic hepatitis' supported by the sentence: 'CONCLUSIONS: Combination therapy of adalimumab and ciprofloxacin is more effective than adalimumab monotherapy to achieve fistula closure in CD.'?,"No, the statement does not provide any direct or indirect support for the connection between methylprednisolone and alcoholic hepatitis. The conclusion is about the efficacy of combination therapy (adalimumab and ciprofloxacin) versus adalimumab monotherapy in achieving fistula closure in Crohn's disease (CD). There is no mention or implication of methylprednisolone or alcoholic hepatitis in this statement." +24559507,Methylprednisolone related to respiratory system disorder,500,"Tested substances displayed inhibitory effect towards E. coli DNA gyrase, though less than ciprofloxacin.",False,"Is the triple 'Methylprednisolone related to respiratory system disorder' supported by the sentence: 'Tested substances displayed inhibitory effect towards E. coli DNA gyrase, though less than ciprofloxacin.'?","No, the statement does not provide indirect support for the phrase ""Methylprednisolone related to respiratory system disorder"". The statement discusses tested substances displaying an inhibitory effect towards Escherichia coli (E. coli) DNA gyrase, which is an enzyme involved in bacterial DNA replication. Methylprednisolone is a corticosteroid hormone medication used primarily for its anti-inflammatory effects in various conditions such as allergies, arthritis, and autoimmune disorders. It has no direct relation to E. coli DNA gyrase or respiratory system disorders." +23573980,Methylprednisolone related to pneumonia,1,Evaluation of granulated fenbendazole (22.2%) against induced and naturally occurring helminth infections in cats.,False,Is the triple 'Methylprednisolone related to pneumonia' supported by the sentence: 'Evaluation of granulated fenbendazole (22.2%) against induced and naturally occurring helminth infections in cats.'?,"No, the statement ""Evaluation of granulated fenbendazole (22.2%) against induced and naturally occurring helminth infections in cats"" does not provide indirect support for the phrase ""Methylprednisolone related to pneumonia."" The statement discusses an evaluation of fenbendazole, an anthelmintic drug used for treating parasitic worm infections in cats, against naturally occurring helminth infections. Methylprednisolone is a corticosteroid used for its anti-inflammatory effects in various conditions; it is unrelated to fenbendazole or helminth infections in cats. Therefore, there is no connection between these two pieces of information that would support methylprednisolone being related to pneumonia." +23514846,Methylprednisolone related to carpal tunnel syndrome,2,Fenbendazole resistance in O. ostertagi was confirmed with a total treatment failure in reducing worm burden: efficacy of 0%.,False,Is the triple 'Methylprednisolone related to carpal tunnel syndrome' supported by the sentence: 'Fenbendazole resistance in O. ostertagi was confirmed with a total treatment failure in reducing worm burden: efficacy of 0%.'?,"No, the statement does not provide indirect support for the phrase ""Methylprednisolone related to carpal tunnel syndrome."" The two statements discuss unrelated subjects: one about fenbendazole resistance in O. ostertagi (a type of parasitic worm affecting cattle) and its treatment efficacy, while the other connects methylprednisolone (a corticosteroid medication) to carpal tunnel syndrome (a medical condition affecting the wrist). + + The connection between methylprednisolone and carpal tunnel syndrome is not mentioned nor implied in any way in the statement about fenbendazole resistance in O. ostertagi. To establish indirect support for such a connection, there should be some commonality between the subjects discussed in both statements, which is absent in this case." +23364897,Methylprednisolone related to West syndrome,3,Symptoms of perianal itching and visualization of visible motile worms persisted for 6 months despite being treated with multiple courses of albendazole causing a lot of frustration and distress to the caregivers.,False,Is the triple 'Methylprednisolone related to West syndrome' supported by the sentence: 'Symptoms of perianal itching and visualization of visible motile worms persisted for 6 months despite being treated with multiple courses of albendazole causing a lot of frustration and distress to the caregivers.'?,"No, the phrase ""Methylprednisolone related to West syndrome"" does not receive indirect support from the statement provided. The statement discusses a patient being treated for symptoms related to perianal itching and visible motile worms that persisted for 6 months despite multiple courses of albendazole treatment. This situation is not related to Methylprednisolone usage nor West syndrome, which is a severe form of childhood epilepsy characterized by infantile spasms, hypsarrhythmia on EEG, and psychomotor retardation. Therefore, there is no connection between the statement and Methylprednisolone being related to West syndrome." +22495910,Methylprednisolone related to myocarditis,4,"Ovicidal effects of albendazole in human ascariasis, ancylostomiasis and trichuriasis.",False,"Is the triple 'Methylprednisolone related to myocarditis' supported by the sentence: 'Ovicidal effects of albendazole in human ascariasis, ancylostomiasis and trichuriasis.'?","No, the statement ""Ovicidal effects of albendazole in human ascariasis, ancylostomiasis and trichuriasis"" does not provide indirect support for the phrase ""Methylprednisolone related to myocarditis."" The two statements discuss different topics: one is about the ovicidal effects (the ability to kill the eggs) of albendazole on certain parasites in humans (ascariasis, ancylostomiasis, trichuriasis), while the other is about methylprednisolone potentially being associated with myocarditis (inflammation of heart muscle). To establish indirect support between these two statements, there should be some common ground in terms of shared concepts, mechanisms, or contexts that would allow for inferential reasoning; however, no such link is apparent here." +22175056,Methylprednisolone related to myopathy,5,"A combination of drugs Ivermectin, Diethylcarbamazine citrate and Albendazole is recommended by WHO to accelerate the Global Programme to Eliminate Lymphatic Filariasis (GPELF).",False,"Is the triple 'Methylprednisolone related to myopathy' supported by the sentence: 'A combination of drugs Ivermectin, Diethylcarbamazine citrate and Albendazole is recommended by WHO to accelerate the Global Programme to Eliminate Lymphatic Filariasis (GPELF).'?","No, the statement does not provide indirect support for the phrase ""Methylprednisolone related to myopathy"". The two statements discuss different topics: one is about a recommended treatment for lymphatic filariasis by the World Health Organization (WHO), while the other refers to a potential side effect of a specific drug called Methylprednisolone. There is no connection between these two ideas in the provided statement." +20879022,Methylprednisolone related to Pain,6,Effect of albendazole in experimental toxocariasis of mice.,False,Is the triple 'Methylprednisolone related to Pain' supported by the sentence: 'Effect of albendazole in experimental toxocariasis of mice.'?,"No, the statement ""Effect of albendazole in experimental toxocariasis of mice"" does not provide any direct or indirect support for the phrase ""Methylprednisolone related to Pain"". The two statements discuss different subjects: one is about the effects of an anthelmintic drug (albendazole) on experimental toxocariasis in mice, while the other refers to methylprednisolone's potential relationship with pain. To establish support for the connection between methylprednisolone and pain, one would need evidence specifically pertaining to that relationship." +20342058,Methylprednisolone related to chronic progressive multiple sclerosis,7,"Given the low helminth prevalence in our children, the effect of albendazole on malaria is likely to be direct.",False,"Is the triple 'Methylprednisolone related to chronic progressive multiple sclerosis' supported by the sentence: 'Given the low helminth prevalence in our children, the effect of albendazole on malaria is likely to be direct.'?","No, there is no direct or indirect support for the phrase ""Methylprednisolone related to chronic progressive multiple sclerosis"" in the statement ""Given the low helminth prevalence in our children, the effect of albendazole on malaria is likely to be direct."" + + The statement concerns the relationship between helminth prevalence, albendazole (an anti-parasitic drug), and malaria in children. The argument is that since helminth prevalence is low, albendazole is likely to have a direct effect on malaria rather than an indirect effect through helminth control. + + Methylprednisolone is a corticosteroid used primarily for its anti-inflammatory effects in conditions such as asthma, rheumatoid arthritis, and multiple sclerosis flare-ups. Chronic progressive multiple sclerosis is a specific form of multiple sclerosis characterized by steady worsening over time without distinct relapses or remissions. + + The two subjects—albendazole/malaria/helminths and Methyl" +20290784,Methylprednisolone related to membranous glomerulonephritis,8,"Mass co-administration of ivermectin and albendazole by the LFEP had a significant effect on STH, which was further amplified by treatment with praziquantel and albendazole 4 months later.",False,"Is the triple 'Methylprednisolone related to membranous glomerulonephritis' supported by the sentence: 'Mass co-administration of ivermectin and albendazole by the LFEP had a significant effect on STH, which was further amplified by treatment with praziquantel and albendazole 4 months later.'?","No, the statement does not provide indirect support for the phrase ""Methylprednisolone related to membranous glomerulonephritis."" The statement discusses the impact of co-administering ivermectin and albendazole by the LFEP on Strongyloides stercoralis (STH), which was later amplified by treatment with praziquantel and albendazole. There is no mention or implication of methylprednisolone or membranous glomerulonephritis in this context." +20286711,Methylprednisolone related to neuromyelitis optica,9,The effect of single dose ivermectin alone or in combination with albendazole on Wuchereria bancrofti infection in primary school children in Tanzania.,False,Is the triple 'Methylprednisolone related to neuromyelitis optica' supported by the sentence: 'The effect of single dose ivermectin alone or in combination with albendazole on Wuchereria bancrofti infection in primary school children in Tanzania.'?,"No, the statement does not provide any direct or indirect support for the phrase ""Methylprednisolone related to neuromyelitis optica."" The study mentioned investigates the effect of ivermectin alone or in combination with albendazole on Wuchereria bancrofti infection in primary school children in Tanzania. This study does not involve methylprednisolone or discuss neuromyelitis optica; thus, it does not provide any relevant information or support for the given phrase." +19340184,Methylprednisolone related to chronic obstructive pulmonary disease,10,"Additionally, compared with albendazole, it resulted in a significant reduction in adult worm and total larval counts; moreover, it caused a decrease in the number of larvae deposited in muscles, with a highly significant decrease in the inflammatory cell infiltrate around the larvae and a considerable decrease in the expression of the angiogenic marker vascular endothelial growth factor in muscles.",False,"Is the triple 'Methylprednisolone related to chronic obstructive pulmonary disease' supported by the sentence: 'Additionally, compared with albendazole, it resulted in a significant reduction in adult worm and total larval counts; moreover, it caused a decrease in the number of larvae deposited in muscles, with a highly significant decrease in the inflammatory cell infiltrate around the larvae and a considerable decrease in the expression of the angiogenic marker vascular endothelial growth factor in muscles.'?","No, the statement does not provide indirect support for the phrase ""Methylprednisolone related to chronic obstructive pulmonary disease."" The statement discusses the effects of Methylprednisolone on adult worm and total larval counts, larvae deposition in muscles, inflammatory cell infiltrate around larvae, and vascular endothelial growth factor expression in muscles; however, it does not mention nor imply any connection between Methylprednisolone and chronic obstructive pulmonary disease (COPD). + + The two concepts—Methylprednisolone and COPD—are unrelated in the provided context. Methylprednisolone is a corticosteroid used primarily for its anti-inflammatory effects in various conditions such as allergies, asthma, arthritis, and autoimmune diseases. Chronic obstructive pulmonary disease (COPD), on the other hand, is characterized by progressive airflow limitation due to chronic bronchitis, emphysema, or both. + + Although Methylprednisolone could potentially be used off-label in some" +18938435,Methylprednisolone related to graft versus host disease,11,"Quarterly albendazole during childhood was associated with reduced incidence of clinical malaria (HR 0.85 (95% CI 0.73-0.98), p = 0.03).",False,"Is the triple 'Methylprednisolone related to graft versus host disease' supported by the sentence: 'Quarterly albendazole during childhood was associated with reduced incidence of clinical malaria (HR 0.85 (95% CI 0.73-0.98), p = 0.03).'?","No, the statement does not provide indirect support for the phrase ""Methylprednisolone related to graft versus host disease"". The statement discusses the association between quarterly albendazole during childhood and reduced incidence of clinical malaria. This has no direct or indirect relation to methylprednisolone or graft versus host disease." +17333962,Methylprednisolone related to Inflammation,12,CONCLUSIONS: Mebendazole and albendazole showed reduced efficacy against Ascaris lumbricoides and hookworm infections at the recommended doses.,False,Is the triple 'Methylprednisolone related to Inflammation' supported by the sentence: 'CONCLUSIONS: Mebendazole and albendazole showed reduced efficacy against Ascaris lumbricoides and hookworm infections at the recommended doses.'?,"No, the statement does not provide indirect support for the phrase ""Methylprednisolone related to Inflammation."" The conclusion in the statement is about the reduced efficacy of two drugs, mebendazole and albendazole, against certain parasitic infections. This has no direct or indirect connection to methylprednisolone or inflammation. Methylprednisolone is a corticosteroid often used to reduce inflammation, but there is no mention of it in the given statement." +17288506,Methylprednisolone related to autoimmune thrombocytopenic purpura,13,Evaluation of effectiveness of diethylcarbamazine/albendazole combination in reduction of Wuchereria bancrofti infection using multiple infection parameters.,False,Is the triple 'Methylprednisolone related to autoimmune thrombocytopenic purpura' supported by the sentence: 'Evaluation of effectiveness of diethylcarbamazine/albendazole combination in reduction of Wuchereria bancrofti infection using multiple infection parameters.'?,"No, the statement ""Evaluation of effectiveness of diethylcarbamazine/albendazole combination in reduction of Wuchereria bancrofti infection using multiple infection parameters"" does not provide indirect support for the phrase ""Methylprednisolone related to autoimmune thrombocytopenic purpura"". The statement is about an evaluation of two drugs (diethylcarbamazine/albendazole) in reducing Wuchereria bancrofti infection, which is unrelated to methylprednisolone and autoimmune thrombocytopenic purpura." +15936572,Methylprednisolone related to endocrine exophthalmos,14,"Our evaluation suggests that although additional studies are needed to determine optimal treatment regimens for intestinal parasites, especially among young children and pregnant women, a five-day course of pre-departure albendazole was effective in reducing helminthic infection in treated refugees.",False,"Is the triple 'Methylprednisolone related to endocrine exophthalmos' supported by the sentence: 'Our evaluation suggests that although additional studies are needed to determine optimal treatment regimens for intestinal parasites, especially among young children and pregnant women, a five-day course of pre-departure albendazole was effective in reducing helminthic infection in treated refugees.'?","No, the statement does not provide indirect support for the phrase ""Methylprednisolone related to endocrine exophthalmos."" The provided statement discusses the effectiveness of pre-departure albendazole treatment in reducing helminthic infection in refugees, which is unrelated to methylprednisolone or endocrine exophthalmos. Endocrine exophthalmos is often associated with Graves' disease, an autoimmune disorder, which would not be directly influenced by anthelmintic drugs like albendazole. Methylprednisolone is a corticosteroid used in various inflammatory conditions but has no direct linkage to endocrine exophthalmos based on this statement." +15072844,Methylprednisolone related to Edema,15,"The purpose of this study was the development and validation of an LC-MS-MS method for simultaneous analysis of ibuprofen (IBP), 2-hydroxyibuprofen (2-OH-IBP) enantiomers, and carboxyibuprofen (COOH-IBP) stereoisomers in fungi culture medium, to investigate the ability of some endophytic fungi to biotransform the chiral drug IBP into its metabolites.",False,"Is the triple 'Methylprednisolone related to Edema' supported by the sentence: 'The purpose of this study was the development and validation of an LC-MS-MS method for simultaneous analysis of ibuprofen (IBP), 2-hydroxyibuprofen (2-OH-IBP) enantiomers, and carboxyibuprofen (COOH-IBP) stereoisomers in fungi culture medium, to investigate the ability of some endophytic fungi to biotransform the chiral drug IBP into its metabolites.'?","No, the statement does not provide indirect support for the phrase ""Methylprednisolone related to Edema"". The study mentioned is focused on developing and validating a method for analyzing ibuprofen (IBP) and its metabolites in fungi culture medium. Methylprednisolone is not mentioned in the statement, nor is there any connection made between it and edema or any other condition. Therefore, it is not appropriate to make such an inference based on the provided information." +14876749,Methylprednisolone related to osteoarthritis,16,"AIMS: To carry out a randomized clinical trial to compare the effect of palmitoylethanolamide (PEA) versus ibuprofen, a nonsteroidal anti-inflammatory drug (NSAID), for pain relief in temporomandibular joint (TMJ) osteoarthritis or arthralgia.",False,"Is the triple 'Methylprednisolone related to osteoarthritis' supported by the sentence: 'AIMS: To carry out a randomized clinical trial to compare the effect of palmitoylethanolamide (PEA) versus ibuprofen, a nonsteroidal anti-inflammatory drug (NSAID), for pain relief in temporomandibular joint (TMJ) osteoarthritis or arthralgia.'?","No, the statement does not provide indirect support for the phrase ""Methylprednisolone related to osteoarthritis."" The statement describes a randomized clinical trial comparing the effects of two substances (palmitoylethanolamide (PEA) and ibuprofen) on pain relief in temporomandibular joint (TMJ) osteoarthritis or arthralgia. Methylprednisolone is not mentioned in the statement; therefore, there is no connection or support for the relationship between methylprednisolone and osteoarthritis in this context." +14399082,Methylprednisolone related to aplastic anemia,17,"We investigated the analgesic efficacy of single doses of ibuprofen, tramadol and pregabalin in menthol-evoked cold pain in a randomized, placebo-controlled four-way cross-over study in 20 healthy volunteers.",False,"Is the triple 'Methylprednisolone related to aplastic anemia' supported by the sentence: 'We investigated the analgesic efficacy of single doses of ibuprofen, tramadol and pregabalin in menthol-evoked cold pain in a randomized, placebo-controlled four-way cross-over study in 20 healthy volunteers.'?","No, the statement does not provide indirect support for the phrase ""Methylprednisolone related to aplastic anemia."" The study mentioned investigates the analgesic efficacy of single doses of ibuprofen, tramadol, and pregabalin in menthol-evoked cold pain in healthy volunteers. Methylprednisolone is not mentioned in the study at all, let alone its relation to aplastic anemia. Aplastic anemia is also not discussed in this context. Therefore, there is no connection that can be inferred between methylprednisolone and aplastic anemia from this statement." +14398237,Methylprednisolone related to IgA glomerulonephritis,18,Double blind study on emorfazone and ibuprofen in dental pain and inflammation.,False,Is the triple 'Methylprednisolone related to IgA glomerulonephritis' supported by the sentence: 'Double blind study on emorfazone and ibuprofen in dental pain and inflammation.'?,"No, the statement ""Methylprednisolone related to IgA glomerulonephritis"" does not receive indirect support from the study on emorfazone and ibuprofen in dental pain and inflammation. The two statements discuss different subjects: methylprednisolone is a corticosteroid used primarily for its anti-inflammatory effect, while IgA glomerulonephritis is a kidney disease often associated with immune system disorders; emorfazone and ibuprofen are both non-steroidal anti-inflammatory drugs (NSAIDs) used primarily for pain relief and reducing inflammation. + + Although both methylprednisolone and NSAIDs have anti-inflammatory properties, their mechanisms of action differ significantly. Furthermore, no connection is implied between them in the provided statement about the double-blind study on emorfazone and ibuprofen in dental pain and inflammation. Therefore, it does not provide indirect support for any relationship between methylprednisolone and IgA glomerulonephritis." +14278238,"Methylprednisolone related to dermatitis, atopic",19,Glucosamine sulfate compared to ibuprofen in osteoarthritis of the knee.,False,"Is the triple 'Methylprednisolone related to dermatitis, atopic' supported by the sentence: 'Glucosamine sulfate compared to ibuprofen in osteoarthritis of the knee.'?","No, the statement ""Glucosamine sulfate compared to ibuprofen in osteoarthritis of the knee"" does not provide indirect support for the phrase ""Methylprednisolone related to dermatitis, atopic."" These two statements discuss different medical conditions (osteoarthritis vs dermatitis) and different treatments (glucosamine sulfate vs methylprednisolone). The first statement does not make any reference or implication about methylprednisolone nor atopic dermatitis; therefore, it does not offer any indirect support for the connection between methylprednisolone and atopic dermatitis. + + To further clarify, methylprednisolone is a corticosteroid often used in treating various inflammatory conditions, while glucosamine sulfate is a supplement used for managing osteoarthritis symptoms. Atopic dermatitis is an allergic skin condition that may be treated using topical corticosteroids like hydrocortisone but not necessarily methylprednisolone. The two statements come from entirely different contexts, making it impossible for one" +14166179,Methylprednisolone related to cardiac arrest,20,INTRODUCTION: The anti-inflammatory and anticoagulant effects of ibuprofen and heparin may enhance skin perfusion in cutaneous scald burns.,False,Is the triple 'Methylprednisolone related to cardiac arrest' supported by the sentence: 'INTRODUCTION: The anti-inflammatory and anticoagulant effects of ibuprofen and heparin may enhance skin perfusion in cutaneous scald burns.'?,"No, the statement does not provide indirect support for the phrase ""Methylprednisolone related to cardiac arrest."" The introduction discusses the potential benefits of ibuprofen and heparin in enhancing skin perfusion in cutaneous scald burns by highlighting their anti-inflammatory and anticoagulant effects. Methylprednisolone is not mentioned in the statement; therefore, no connection can be inferred between it and cardiac arrest in this context. + + To provide indirect support for ""Methylprednisolone related to cardiac arrest,"" there would need to be some mention of methylprednisolone in relation to cardiac issues or adverse effects on heart function, which is not present in the given statement." +12755316,Methylprednisolone related to plasma cell myeloma,21,"CONCLUSIONS: Ibuprofen-induced patent ductus arteriosus closure improved pulmonary mechanics, decreased total lung water, increased epithelial sodium channel expression, and decreased the detrimental effects of preterm birth on alveolarization.",False,"Is the triple 'Methylprednisolone related to plasma cell myeloma' supported by the sentence: 'CONCLUSIONS: Ibuprofen-induced patent ductus arteriosus closure improved pulmonary mechanics, decreased total lung water, increased epithelial sodium channel expression, and decreased the detrimental effects of preterm birth on alveolarization.'?","No, the statement does not provide indirect support for the phrase ""Methylprednisolone related to plasma cell myeloma."" The conclusion discusses the effects of ibuprofen on patent ductus arteriosus closure in preterm births, which is unrelated to methylprednisolone usage in plasma cell myeloma cases. The two subjects involve different medications and medical conditions, making it inappropriate to draw any connections between them based on this statement alone." +12183687,Methylprednisolone related to acute lymphoblastic leukemia,22,Protein profile in neuroblastoma cells incubated with S- and R-enantiomers of ibuprofen by iTRAQ-coupled 2-D LC-MS/MS analysis: possible action of induced proteins on Alzheimer's disease.,False,Is the triple 'Methylprednisolone related to acute lymphoblastic leukemia' supported by the sentence: 'Protein profile in neuroblastoma cells incubated with S- and R-enantiomers of ibuprofen by iTRAQ-coupled 2-D LC-MS/MS analysis: possible action of induced proteins on Alzheimer's disease.'?,"No, the statement does not provide indirect support for the phrase ""Methylprednisolone related to acute lymphoblastic leukemia."" The statement discusses neuroblastoma cells incubated with S-and R-enantiomers of ibuprofen, not methylprednisolone, and focuses on protein profiles possibly influencing Alzheimer's disease, not acute lymphoblastic leukemia." +11720471,Methylprednisolone related to systemic lupus erythematosus,23,Protective effect of glucosamine against ibuprofen-induced peptic ulcer in rats.,False,Is the triple 'Methylprednisolone related to systemic lupus erythematosus' supported by the sentence: 'Protective effect of glucosamine against ibuprofen-induced peptic ulcer in rats.'?,"No, the statement ""Protective effect of glucosamine against ibuprofen-induced peptic ulcer in rats"" does not provide indirect support for the phrase ""Methylprednisolone related to systemic lupus erythematosus"". + + The reason for this is that the two statements discuss entirely different subjects. The first statement refers to the protective effect of glucosamine on ibuprofen-induced peptic ulcers in rats, which is an investigation into gastrointestinal side effects caused by non-steroidal anti-inflammatory drugs (NSAIDs). In contrast, the second phrase discusses Methylprednisolone, which is a corticosteroid used primarily for its anti-inflammatory effects in various clinical settings such as systemic lupus erythematosus (SLE). + + While both glucosamine and Methylprednisolone have anti-inflammatory properties, they belong to different classes of drugs (nutraceuticals and corticosteroids, respectively) that have distinct mechanisms of action, therapeutic uses, and adverse effect profiles" +10812685,Methylprednisolone related to immunoglobulin a vasculitis,24,Ibuprofen-induced fever in Sjogren's syndrome.,False,Is the triple 'Methylprednisolone related to immunoglobulin a vasculitis' supported by the sentence: 'Ibuprofen-induced fever in Sjogren's syndrome.'?,"No, the statement ""Ibuprofen-induced fever in Sjogren's syndrome"" does not provide indirect support for the phrase ""Methylprednisolone related to immunoglobulin A vasculitis."" + + + The two statements discuss different medical conditions and drugs. Sjogren's syndrome is an autoimmune disorder characterized by dry eyes and mouth, while immunoglobulin A vasculitis (IgAV), previously known as Henoch-Schönlein purpura, is a type of vasculitis that affects small blood vessels. Methylprednisolone is a corticosteroid used in various inflammatory conditions, including IgAV, whereas ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) that can cause fever as an adverse effect in some patients. + + + Although both methylprednisolone and ibuprofen can be used in inflammatory conditions, they belong to different drug classes (corticosteroids vs NSAIDs) and have distinct mechanisms of action. Therefore, one statement does not provide indirect" +10763477,Methylprednisolone related to ulcerative colitis,25,There have been no prior definite cases reported of ibuprofen-induced pancreatitis.,False,Is the triple 'Methylprednisolone related to ulcerative colitis' supported by the sentence: 'There have been no prior definite cases reported of ibuprofen-induced pancreatitis.'?,"No, the statement ""There have been no prior definite cases reported of ibuprofen-induced pancreatitis"" does not provide indirect support for the phrase ""Methylprednisolone related to ulcerative colitis."" + + The two statements discuss different medications (ibuprofen and methylprednisolone) and different medical conditions (pancreatitis and ulcerative colitis). Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID), while methylprednisolone is a corticosteroid used primarily for its anti-inflammatory effects in various conditions such as ulcerative colitis. + + The lack of reported ibuprofen-induced pancreatitis cases does not imply any connection between methylprednisolone and ulcerative colitis, as these medications have different mechanisms of action and potential side effects. To establish any relationship between methylprednisolone and ulcerative colitis, direct evidence from relevant studies would be required, focusing on methylprednisolone use in ulcerative colitis patients and its associated outcomes, side effects, or benefits." +10558884,Methylprednisolone related to lupus nephritis,26,"RESULTS: None of the studies established any of the COX-2 inhibitors as clearly better than ibuprofen, the current gold standard for the treatment of surgically induced dental pain.",False,"Is the triple 'Methylprednisolone related to lupus nephritis' supported by the sentence: 'RESULTS: None of the studies established any of the COX-2 inhibitors as clearly better than ibuprofen, the current gold standard for the treatment of surgically induced dental pain.'?","No, the statement does not provide indirect support for the phrase ""Methylprednisolone related to lupus nephritis."" The statement discusses studies comparing COX-2 inhibitors (such as celecoxib) to ibuprofen for treating surgically induced dental pain, without mentioning methylprednisolone or lupus nephritis at all. Methylprednisolone is a corticosteroid used primarily for its anti-inflammatory effects in various conditions like asthma, rheumatoid arthritis, and lupus nephritis flares; it is not a COX-2 inhibitor nor an NSAID like ibuprofen. Therefore, these results do not provide any relevant evidence regarding methylprednisolone's relationship to lupus nephritis." +10130342,Methylprednisolone related to adult acute respiratory distress syndrome,27,Noncardiogenic pulmonary edema due to ibuprofen.,False,Is the triple 'Methylprednisolone related to adult acute respiratory distress syndrome' supported by the sentence: 'Noncardiogenic pulmonary edema due to ibuprofen.'?,"No, the statement ""Noncardiogenic pulmonary edema due to ibuprofen"" does not provide indirect support for the phrase ""Methylprednisolone related to adult acute respiratory distress syndrome."" + + The two statements describe different drugs (ibuprofen and methylprednisolone) causing distinct medical conditions (noncardiogenic pulmonary edema and adult acute respiratory distress syndrome). While both conditions affect lung function, they represent different pathophysiological mechanisms: noncardiogenic pulmonary edema is characterized by increased fluid accumulation in lung tissue due to increased permeability, while adult acute respiratory distress syndrome (ARDS) is an inflammatory lung injury leading to hypoxemia (low oxygen levels in blood) due to impaired gas exchange in alveoli. + + Methylprednisolone is a corticosteroid commonly used in treating various inflammatory conditions; however, its use in ARDS remains controversial due to potential side effects like increased susceptibility to infections. Ibuprofen is an NSAID (nonsteroidal anti-inflammatory drug" +9229208,Methylprednisolone related to vestibular neuronitis,28,"In a double-blind cross-over study on 22 healthy subjects the analgesic efficacies of the antipyretic analgesic drugs ibuprofen, dipyrone and paracetamol were tested against placebo using a model of experimentally induced pain.",False,"Is the triple 'Methylprednisolone related to vestibular neuronitis' supported by the sentence: 'In a double-blind cross-over study on 22 healthy subjects the analgesic efficacies of the antipyretic analgesic drugs ibuprofen, dipyrone and paracetamol were tested against placebo using a model of experimentally induced pain.'?","No, the statement does not provide indirect support for the phrase ""Methylprednisolone related to vestibular neuronitis"". The study mentioned in the statement focuses on testing analgesic efficacies of ibuprofen, dipyrone, paracetamol against placebo in experimentally induced pain in 22 healthy subjects. Methylprednisolone is not included in these drugs nor is there any reference made to vestibular neuronitis in the study. Vestibular neuronitis is an inner ear disorder causing vertigo while methylprednisolone is a corticosteroid used primarily for its anti-inflammatory effects in various conditions. Therefore, there is no connection between methylprednisolone and vestibular neuronitis in this context." +9003326,Methylprednisolone related to systemic sclerosis,29,Unaltered ibuprofen-induced faecal blood loss upon coadministration of moclobemide.,False,Is the triple 'Methylprednisolone related to systemic sclerosis' supported by the sentence: 'Unaltered ibuprofen-induced faecal blood loss upon coadministration of moclobemide.'?,"No, the statement does not provide indirect support for the phrase ""Methylprednisolone related to systemic sclerosis."" The statement discusses the effect of ibuprofen-induced faecal blood loss when coadministered with moclobemide, which is unrelated to methylprednisolone or systemic sclerosis. Methylprednisolone is a corticosteroid used primarily for its anti-inflammatory effects, while systemic sclerosis is an autoimmune disease characterized by hardening of the skin and connective tissues. The connection between these entities is not evident based on the provided statement." +8447481,Methylprednisolone related to rheumatoid arthritis,30,The C5a antagonist (1 or 3 mg/kg/day) and/or ibuprofen (30 mg/kg/day) were administered orally on a daily basis either before or after arthritis induction.,False,Is the triple 'Methylprednisolone related to rheumatoid arthritis' supported by the sentence: 'The C5a antagonist (1 or 3 mg/kg/day) and/or ibuprofen (30 mg/kg/day) were administered orally on a daily basis either before or after arthritis induction.'?,"No, the statement does not provide direct or indirect support for the phrase ""Methylprednisolone related to rheumatoid arthritis."" The statement discusses the administration of C5a antagonist and ibuprofen in relation to arthritis induction but does not mention Methylprednisolone or its relation to rheumatoid arthritis." +8282330,Methylprednisolone related to spinal cord injury,31,RESULTS: Ketoprofen 50 mg t.d.s. suppressed prostaglandin synthesis to a significantly greater extent than ibuprofen and caused significantly more gastroduodenal injury.,False,Is the triple 'Methylprednisolone related to spinal cord injury' supported by the sentence: 'RESULTS: Ketoprofen 50 mg t.d.s. suppressed prostaglandin synthesis to a significantly greater extent than ibuprofen and caused significantly more gastroduodenal injury.'?,"No, the statement does not provide indirect support for the phrase ""Methylprednisolone related to spinal cord injury."" The statement discusses the effects of Ketoprofen and Ibuprofen on prostaglandin synthesis and gastroduodenal injury, making no mention of Methylprednisolone or its relationship to spinal cord injury. Methylprednisolone is a type of corticosteroid often used in treating various medical conditions, including spinal cord injuries, but the evidence provided here does not support any connection between it and spinal cord injury." +7944646,Methylprednisolone related to myasthenia gravis,32,The duration of action of sustained-release ibuprofen ('Brufen Retard') was investigated in a 14-day double-blind study involving 14 osteoarthritis and 10 rheumatoid arthritis patients.,False,Is the triple 'Methylprednisolone related to myasthenia gravis' supported by the sentence: 'The duration of action of sustained-release ibuprofen ('Brufen Retard') was investigated in a 14-day double-blind study involving 14 osteoarthritis and 10 rheumatoid arthritis patients.'?,"No, the statement does not provide indirect support for the phrase ""Methylprednisolone related to myasthenia gravis."" The study mentioned in the statement investigates the duration of action of sustained-release ibuprofen (Brufen Retard) in osteoarthritis and rheumatoid arthritis patients. Methylprednisolone is a corticosteroid used primarily for its anti-inflammatory effects in various conditions, while myasthenia gravis is an autoimmune neuromuscular disorder affecting voluntary muscle function. There is no mention or implication of methylprednisolone, myasthenia gravis, or any related concepts in the provided statement." +7668599,Methylprednisolone related to multiple sclerosis,33,This study attempts to investigate the effect of ibuprofen on reducing eye pain and migraine headaches caused by trochleitis.,False,Is the triple 'Methylprednisolone related to multiple sclerosis' supported by the sentence: 'This study attempts to investigate the effect of ibuprofen on reducing eye pain and migraine headaches caused by trochleitis.'?,"No, the statement does not provide indirect support for the phrase ""Methylprednisolone related to multiple sclerosis."" The study mentioned is investigating the effect of ibuprofen on reducing eye pain and migraine headaches caused by trochleitis. There is no mention or implication of methylprednisolone or multiple sclerosis in this context. Methylprednisolone is a corticosteroid used primarily for its anti-inflammatory effects in various conditions, while multiple sclerosis is an autoimmune disease affecting the central nervous system; they share no direct relationship to each other nor to ibuprofen or trochleitis in this specific case." +7443745,Methylprednisolone related to asthma,34,"Ibuprofen suppresses the production of various pro-inflammatory cytokines that are implicated in the ""cytokine storm"" and subsequent ARDS in COVID-19 disease.",False,"Is the triple 'Methylprednisolone related to asthma' supported by the sentence: 'Ibuprofen suppresses the production of various pro-inflammatory cytokines that are implicated in the ""cytokine storm"" and subsequent ARDS in COVID-19 disease.'?","No, the statement does not provide indirect support for the phrase ""Methylprednisolone related to asthma."" The two statements discuss different medications (Ibuprofen vs Methylprednisolone) and different medical conditions (COVID-19 vs asthma). Ibuprofen's effect on COVID-19 does not imply any connection to Methylprednisolone's potential relation to asthma. Methylprednisolone is a corticosteroid often used in asthma treatment due to its anti-inflammatory properties; however, that is not mentioned nor implied in the original statement about Ibuprofen and COVID-19." +24973247,Methylprednisolone causes lupus nephritis,35,"After adjusting for covariates, the risk of BPD was associated independently with ibuprofen exposure (odds ratios (OR) 2.296, 95% confidence interval (CI): 1.166-4.522, p = 0.016).",False,"Is the triple 'Methylprednisolone causes lupus nephritis' supported by the sentence: 'After adjusting for covariates, the risk of BPD was associated independently with ibuprofen exposure (odds ratios (OR) 2.296, 95% confidence interval (CI): 1.166-4.522, p = 0.016).'?","No, the statement does not provide any indirect support for the claim that ""Methylprednisolone causes lupus nephritis."" The statement discusses the association between ibuprofen exposure and bronchopulmonary dysplasia (BPD) in infants, adjusted for covariates. Methylprednisolone is not mentioned in the statement at all; hence, there is no link between the two pieces of information that would allow for indirect support. Lupus nephritis is also not mentioned in either statement. Therefore, it is not possible to draw any conclusions about the relationship between methylprednisolone use and lupus nephritis based on these statements alone." +24161886,Methylprednisolone causes Edema,36,The opposite effect of ibuprofen on ethanol-induced cognitive impairment as measured by two lateralized functions is consistent with the reports in tissue and animal models that central nervous system effects of ethanol may be mediated at least in part by prostaglandins.,False,Is the triple 'Methylprednisolone causes Edema' supported by the sentence: 'The opposite effect of ibuprofen on ethanol-induced cognitive impairment as measured by two lateralized functions is consistent with the reports in tissue and animal models that central nervous system effects of ethanol may be mediated at least in part by prostaglandins.'?,"No, the statement does not provide indirect support for the phrase ""Methylprednisolone causes Edema"". + + The statement discusses the opposite effect of ibuprofen on ethanol-induced cognitive impairment, which is suggested to be mediated by prostaglandins in tissue and animal models. Methylprednisolone is a corticosteroid medication used for its anti-inflammatory and immunosuppressive effects, and it does not have a direct connection to prostaglandins, ethanol, or cognitive impairment as described in the statement. Therefore, there is no implied relationship between methylprednisolone and edema in this context." +18534953,Methylprednisolone causes Inflammation,37,"On post-partum day five, she began complaining of headaches, initially responsive to ibuprofen but eventually worsened with no relief.",False,"Is the triple 'Methylprednisolone causes Inflammation' supported by the sentence: 'On post-partum day five, she began complaining of headaches, initially responsive to ibuprofen but eventually worsened with no relief.'?","No, the phrase ""Methylprednisolone causes Inflammation"" does not receive indirect support from the statement: ""On post-partum day five, she began complaining of headaches, initially responsive to ibuprofen but eventually worsened with no relief."" + + The statement describes a patient who developed headaches on post-partum day five that were initially responsive to ibuprofen but later became unresponsive. Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID), which suggests that inflammation might have been involved in the initial stages of her headaches. However, methylprednisolone is a glucocorticoid steroid used primarily for its anti-inflammatory effects in various clinical scenarios (e.g., treating inflammatory conditions such as multiple sclerosis). The worsening of her headaches despite initial responsiveness to an anti-inflammatory medication like ibuprofen does not support methylprednisolone causing inflammation; instead, it suggests that her condition might not have been primarily inflammatory in nature or that other factors were contributing to" +18260665,Methylprednisolone causes neoplasm,38,"Because ibuprofen protects from septic lung injury, we studied the effect of ibuprofen in oxidant lung injury from phosgene.",False,"Is the triple 'Methylprednisolone causes neoplasm' supported by the sentence: 'Because ibuprofen protects from septic lung injury, we studied the effect of ibuprofen in oxidant lung injury from phosgene.'?","No, the statement does not provide any indirect support for the phrase ""Methylprednisolone causes neoplasm."" + + The initial statement discusses a study involving ibuprofen in oxidant lung injury from phosgene due to its protective effects against septic lung injury. This study does not involve methylprednisolone or any discussion related to neoplasm (abnormal tissue growth that can lead to cancer). Therefore, it does not provide any basis or evidence to suggest that methylprednisolone causes neoplasm. + + The two statements are unrelated in terms of their subject matter and do not share any common elements that would allow for an indirect inference about methylprednisolone causing neoplasm." +17307095,Methylprednisolone causes pneumonia,39,The efficacy and tolerance of ibuprofen retard at a dose of 2 x 800 mg daily was investigated in an open multicenter study over a period of 3 weeks on 7931 out-patients with activated degenerative joint disease and/or extraarticular rheumatic symptoms.,False,Is the triple 'Methylprednisolone causes pneumonia' supported by the sentence: 'The efficacy and tolerance of ibuprofen retard at a dose of 2 x 800 mg daily was investigated in an open multicenter study over a period of 3 weeks on 7931 out-patients with activated degenerative joint disease and/or extraarticular rheumatic symptoms.'?,"No, the statement does not provide any indirect support for the claim that ""Methylprednisolone causes pneumonia"". The statement discusses a study on ibuprofen's efficacy and tolerance in patients with joint disease and rheumatic symptoms, but it does not mention Methylprednisolone or pneumonia at all. Therefore, it does not contribute any evidence, either positive or negative, towards the claim in question." +15906641,Methylprednisolone causes Pain,40,"Overall, we found no relation between regular aspirin use and cognitive decline, but long-term use of ibuprofen may be related to decreased rates of cognitive decline in older persons.",False,"Is the triple 'Methylprednisolone causes Pain' supported by the sentence: 'Overall, we found no relation between regular aspirin use and cognitive decline, but long-term use of ibuprofen may be related to decreased rates of cognitive decline in older persons.'?","No, the statement does not provide indirect support for the phrase ""Methylprednisolone causes Pain."" The provided statement discusses the relationship between regular aspirin use, ibuprofen use, and cognitive decline in older persons; it does not mention Methylprednisolone or pain at all. Methylprednisolone is a corticosteroid used primarily for its anti-inflammatory effects, while aspirin and ibuprofen are nonsteroidal anti-inflammatory drugs (NSAIDs). The provided statement does not offer any evidence or reasoning that could be used to infer a relationship between Methylprednisolone and pain." +13166073,Methylprednisolone causes thrombocytopenia,41,"Subdiaphragmatic vagotomy or 7-nitroindazole reduced, icatibant, DALBK, IL-1ra, aminoguanidine and dipyrone abolished, while ibuprofen and celecoxib failed to affect Tsv-induced fever.",False,"Is the triple 'Methylprednisolone causes thrombocytopenia' supported by the sentence: 'Subdiaphragmatic vagotomy or 7-nitroindazole reduced, icatibant, DALBK, IL-1ra, aminoguanidine and dipyrone abolished, while ibuprofen and celecoxib failed to affect Tsv-induced fever.'?","No, the statement does not provide indirect support for the phrase ""Methylprednisolone causes thrombocytopenia"". The statement discusses various substances (subdiaphragmatic vagotomy, 7-nitroindazole, icatibant, DALBK, IL-1ra, aminoguanidine, dipyrone, ibuprofen, and celecoxib) affecting Tsv-induced fever in rats, but it does not mention methylprednisolone nor thrombocytopenia (a condition characterized by abnormally low levels of platelets in the blood). Methylprednisolone is a corticosteroid medication used for various inflammatory conditions, while thrombocytopenia is not related to fever in rats. Therefore, there is no connection between the two statements that would allow for indirect support of the claim about methylprednisolone causing thrombocytopenia." +12672767,Methylprednisolone causes drug-induced liver injury,42,Reduced incidence of gastroduodenal ulcers associated with lumiracoxib compared with ibuprofen in patients with rheumatoid arthritis.,False,Is the triple 'Methylprednisolone causes drug-induced liver injury' supported by the sentence: 'Reduced incidence of gastroduodenal ulcers associated with lumiracoxib compared with ibuprofen in patients with rheumatoid arthritis.'?,"No, the statement does not provide indirect support for the phrase ""Methylprednisolone causes drug-induced liver injury"". + + The statement discusses the reduced incidence of gastroduodenal ulcers associated with lumiracoxib compared to ibuprofen in patients with rheumatoid arthritis. This has no direct or indirect relation to methylprednisolone, which is not mentioned in the statement. Methylprednisolone is a corticosteroid often used for its anti-inflammatory effects, while lumiracoxib and ibuprofen are non-steroidal anti-inflammatory drugs (NSAIDs). + + Drug-induced liver injury is indeed a potential side effect of some medications, including certain corticosteroids like methylprednisolone. However, the statement provided does not contain any information that could be used to infer or imply this relationship. Therefore, it does not provide indirect support for the claim that methylprednisolone causes drug-induced liver injury." +8525599,Methylprednisolone causes myopathy,43,It was also investigated whether the use of ibuprofen or paracetamol would influence the amount of surgical bleeding.,False,Is the triple 'Methylprednisolone causes myopathy' supported by the sentence: 'It was also investigated whether the use of ibuprofen or paracetamol would influence the amount of surgical bleeding.'?,"No, the statement does not provide any indirect support for the claim that ""Methylprednisolone causes myopathy."" + + The statement discusses an investigation into whether ibuprofen or paracetamol has an impact on surgical bleeding. This is unrelated to methylprednisolone or myopathy (muscle disease). Myopathy is a side effect associated with methylprednisolone use; however, the provided statement does not mention methylprednisolone or myopathy, making it irrelevant in supporting the initial claim." +27357949,Methylprednisolone affects neoplasm,44,"In a randomised, placebo-controlled, double-blind trial of prophylaxis with ibuprofen, the rate of patent ductus arteriosus associated with ibuprofen was 19% compared with 42% with placebo.",False,"Is the triple 'Methylprednisolone affects neoplasm' supported by the sentence: 'In a randomised, placebo-controlled, double-blind trial of prophylaxis with ibuprofen, the rate of patent ductus arteriosus associated with ibuprofen was 19% compared with 42% with placebo.'?","No, the statement does not provide direct or indirect support for the phrase ""Methylprednisolone affects neoplasm."" The study mentioned involves ibuprofen use in preventing patent ductus arteriosus (PDA), which is not related to neoplasm (abnormal tissue growth that can lead to cancer). Methylprednisolone is also not mentioned in the study. Therefore, there is no link between methylprednisolone and its effect on neoplasm based on this statement alone. + + However, it is important to note that methylprednisolone has been studied in relation to cancer treatment as it can modulate immune response and inflammation; however, its direct effect on neoplasm growth remains unclear and more evidence would be needed for such a claim." +24420470,Methylprednisolone affects Inflammation,45,"The purpose of this study was to examine the effects of ibuprofen on delayed onset muscle soreness (DOMS), indirect markers of muscle damage and muscular performance.",False,"Is the triple 'Methylprednisolone affects Inflammation' supported by the sentence: 'The purpose of this study was to examine the effects of ibuprofen on delayed onset muscle soreness (DOMS), indirect markers of muscle damage and muscular performance.'?","No, the statement does not provide indirect support for the claim that ""Methylprednisolone affects Inflammation."" The study focuses on ibuprofen, another anti-inflammatory drug, examining its effects on delayed onset muscle soreness (DOMS), indirect markers of muscle damage, and muscular performance. The fact that ibuprofen has these effects does not necessarily imply that methylprednisolone would have similar effects on inflammation since different drugs can have different mechanisms of action. To establish indirect support for methylprednisolone affecting inflammation from this study, there would need to be some comparison between ibuprofen and methylprednisolone, which is not present in the given statement." +23472756,Methylprednisolone affects Inflammation,46,CONCLUSIONS: Pretreatment with ibuprofen before elective total hip surgery increases the perioperative blood loss significantly.,False,Is the triple 'Methylprednisolone affects Inflammation' supported by the sentence: 'CONCLUSIONS: Pretreatment with ibuprofen before elective total hip surgery increases the perioperative blood loss significantly.'?,"No, the statement does not provide direct or indirect support for the phrase ""Methylprednisolone affects Inflammation."" The conclusion in question discusses the effect of ibuprofen on perioperative blood loss in elective total hip surgery, which is not related to Methylprednisolone or inflammation in any discernible way based on the information provided. Methylprednisolone is a corticosteroid used primarily for its anti-inflammatory effects; however, no mention or implication is made in this statement regarding Methylprednisolone or its potential impact on inflammation." +20530617,Methylprednisolone affects systemic sclerosis,47,"The data suggest that nimesulide and ibuprofen, in addition to their anti-inflammatory and analgesic benefits, may also have a protective effect in osteoarthritis through the inhibition of apoptosis in chondrocytes.",False,"Is the triple 'Methylprednisolone affects systemic sclerosis' supported by the sentence: 'The data suggest that nimesulide and ibuprofen, in addition to their anti-inflammatory and analgesic benefits, may also have a protective effect in osteoarthritis through the inhibition of apoptosis in chondrocytes.'?","No, the statement does not provide indirect support for the claim that ""Methylprednisolone affects systemic sclerosis."" The statement discusses the potential protective effects of nimesulide and ibuprofen on osteoarthritis through inhibition of apoptosis in chondrocytes, which is unrelated to methylprednisolone or systemic sclerosis. Systemic sclerosis is an autoimmune disease characterized by thickening and scarring of connective tissue supporting skin and internal organs, whereas osteoarthritis is a degenerative joint disease primarily affecting cartilage. Methylprednisolone is a corticosteroid used primarily for its anti-inflammatory effects in various conditions; its impact on systemic sclerosis would require separate investigation and evidence." +20254789,Methylprednisolone affects adult acute respiratory distress syndrome,48,Pretreatment with ibuprofen blocked the fever induced by RANTES.,False,Is the triple 'Methylprednisolone affects adult acute respiratory distress syndrome' supported by the sentence: 'Pretreatment with ibuprofen blocked the fever induced by RANTES.'?,"No, the statement does not provide indirect support for the phrase ""Methylprednisolone affects adult acute respiratory distress syndrome"". The statement ""Pretreatment with ibuprofen blocked the fever induced by RANTES"" discusses the effects of ibuprofen on fever induced by RANTES but does not mention methylprednisolone or its effects on adult acute respiratory distress syndrome (ARDS). + + To provide indirect support for the initial phrase, there would need to be some connection between ibuprofen/RANTES/fever and methylprednisolone/ARDS in the statement. However, no such connection is present in this case. + + It is important to note that while methylprednisolone is sometimes used in treating ARDS due to its anti-inflammatory properties, ibuprofen is primarily used as an analgesic (pain reliever) and antipyretic (fever reducer). They have different mechanisms of action in the body, so one does not necessarily influence the other in terms of their primary effects (ibuprofen reducing fever from RANTES in this case). + + In conclusion" +17649050,Methylprednisolone affects optic nerve disorder,49,This study evaluated whether administration of the pharmacologically active S(+)-isomer of ibuprofen suppresses acute pain and plasma beta-endorphin levels in the oral surgery model of acute pain.,False,Is the triple 'Methylprednisolone affects optic nerve disorder' supported by the sentence: 'This study evaluated whether administration of the pharmacologically active S(+)-isomer of ibuprofen suppresses acute pain and plasma beta-endorphin levels in the oral surgery model of acute pain.'?,"No, the statement does not provide any direct or indirect support for the phrase ""Methylprednisolone affects optic nerve disorder."" The study mentioned in the statement is investigating whether administering ibuprofen suppresses acute pain and plasma beta-endorphin levels in an oral surgery model for acute pain management. This study is focused on ibuprofen and pain management, making it unrelated to methylprednisolone or its potential effects on optic nerve disorders." +16634377,Methylprednisolone affects myasthenia gravis,50,"On the other hand, in subgroup B, no improvement in flexibility or reduction in muscle soreness was found in patients who took ibuprofen.",False,"Is the triple 'Methylprednisolone affects myasthenia gravis' supported by the sentence: 'On the other hand, in subgroup B, no improvement in flexibility or reduction in muscle soreness was found in patients who took ibuprofen.'?","No, the statement does not provide indirect support for the phrase ""Methylprednisolone affects myasthenia gravis."" The statement discusses the effects of ibuprofen on flexibility and muscle soreness in subgroup B patients but does not mention methylprednisolone or myasthenia gravis at all. + + To provide indirect support for the original phrase, there would need to be some connection between methylprednisolone, myasthenia gravis, and either ibuprofen or flexibility/muscle soreness in the statement. Since no such connection exists here, no indirect support can be inferred from the statement provided." +16277488,Methylprednisolone affects neuromyelitis optica,51,"This is termed, Celery Seed Extract (CSE) and has been found to be at least as effective as aspirin, ibuprofen, and naproxen in suppressing arthritis in a model of polyarthritis.",False,"Is the triple 'Methylprednisolone affects neuromyelitis optica' supported by the sentence: 'This is termed, Celery Seed Extract (CSE) and has been found to be at least as effective as aspirin, ibuprofen, and naproxen in suppressing arthritis in a model of polyarthritis.'?","No, the statement does not provide indirect support for the claim that ""Methylprednisolone affects neuromyelitis optica."" The statement discusses Celery Seed Extract (CSE) and its effectiveness in suppressing arthritis in a polyarthritis model. It does not mention Methylprednisolone or neuromyelitis optica, so there is no connection between the two pieces of information that would allow for indirect support. + + To further explain, Methylprednisolone is a corticosteroid medication used for its anti-inflammatory and immunosuppressive effects in various conditions such as allergic reactions, skin conditions, arthritis, asthma, blood disorders, certain eye conditions, kidney problems, and autoimmune diseases among others (Mayo Clinic). Neuromyelitis optica is an autoimmune disease where immune system attacks the optic nerves and spinal cord (National Institute of Neurological Disorders and Stroke). While Methylprednisolone may be used in treating Neuromyelitis optica due to its immunosuppressive properties, the provided statement does not" +15906642,Methylprednisolone affects Pain,52,INTRODUCTION: Hospitalized patients are often unable to ingest or tolerate oral antipyretics and recently an aqueous formulation of intravenous (IV) ibuprofen was approved by the US-FDA for the reduction of fever in adults.,False,Is the triple 'Methylprednisolone affects Pain' supported by the sentence: 'INTRODUCTION: Hospitalized patients are often unable to ingest or tolerate oral antipyretics and recently an aqueous formulation of intravenous (IV) ibuprofen was approved by the US-FDA for the reduction of fever in adults.'?,"No, the statement does not provide indirect support for the phrase ""Methylprednisolone affects Pain."" The statement discusses hospitalized patients who cannot ingest oral antipyretics (fever reducers) and mentions an intravenous formulation of ibuprofen that was approved by the US-FDA for fever reduction in adults. Methylprednisolone is a corticosteroid used for its anti-inflammatory effects rather than for pain relief in clinical practice; therefore, it is unrelated to pain management in this context." +15610554,Methylprednisolone affects rheumatoid arthritis,53,"OBJECTIVES: This study compared the analgesic effectiveness of acetaminophen-codeine with that of ibuprofen for children with acute traumatic extremity pain, with the hypothesis that the two medications would demonstrate equivalent reduction in pain scores in an emergency department (ED) setting.",False,"Is the triple 'Methylprednisolone affects rheumatoid arthritis' supported by the sentence: 'OBJECTIVES: This study compared the analgesic effectiveness of acetaminophen-codeine with that of ibuprofen for children with acute traumatic extremity pain, with the hypothesis that the two medications would demonstrate equivalent reduction in pain scores in an emergency department (ED) setting.'?","No, the statement does not provide indirect support for the claim that ""Methylprednisolone affects rheumatoid arthritis."" The study mentioned in the statement investigates the analgesic effectiveness of acetaminophen-codeine versus ibuprofen in children suffering from acute traumatic extremity pain in an emergency department setting. There is no mention or implication of methylprednisolone or rheumatoid arthritis in the study objectives provided. Therefore, it does not offer any relevant context or evidence that could be used to infer methylprednisolone's impact on rheumatoid arthritis." +15186368,Methylprednisolone affects graft versus host disease,54,"Thus, the anti-inflammatory drug ibuprofen, which has been associated with reduced AD risk in human epidemiological studies, can significantly delay some forms of AD pathology, including amyloid deposition, when administered early in the disease course of a transgenic mouse model of AD.",False,"Is the triple 'Methylprednisolone affects graft versus host disease' supported by the sentence: 'Thus, the anti-inflammatory drug ibuprofen, which has been associated with reduced AD risk in human epidemiological studies, can significantly delay some forms of AD pathology, including amyloid deposition, when administered early in the disease course of a transgenic mouse model of AD.'?","No, the statement does not provide indirect support for the phrase ""Methylprednisolone affects graft versus host disease"". The statement discusses the effects of ibuprofen on Alzheimer's disease (AD) pathology in a transgenic mouse model, while the phrase pertains to Methylprednisolone's impact on graft versus host disease. These two subjects are unrelated in the context provided." +14891106,Methylprednisolone affects kidney disorder,55,"The hypoxia, hypertension and increased prostanoids were prevented using ibuprofen.",False,"Is the triple 'Methylprednisolone affects kidney disorder' supported by the sentence: 'The hypoxia, hypertension and increased prostanoids were prevented using ibuprofen.'?","No, the statement does not provide indirect support for the phrase ""Methylprednisolone affects kidney disorder"". The statement discusses the prevention of hypoxia, hypertension, and increased prostanoids using ibuprofen; however, it does not mention methylprednisolone or kidney disorder at all. To provide indirect support for the original phrase, there should be some connection between methylprednisolone, kidney disorder, and the factors mentioned in the statement (hypoxia, hypertension, increased prostanoids). Since no such connection is established in the given statement, it does not offer indirect support for the claim about methylprednisolone affecting kidney disorder." +11819955,Methylprednisolone affects spinal cord injury,56,"The Effect of Ibuprofen Dosing Interval on Post-Tonsillectomy Outcomes in Children: A Quality Improvement Study.OBJECTIVE: In this Quality Improvement (QI project) it was hypothesized that an increase in dosing intervals for postoperative analgesia when alternating Ibuprofen and Acetaminophen would reduce post-tonsillectomy hemorrhage (PTH) rates for those undergoing tonsillectomies with or without adenoidectomy, while maintaining the standard of postoperative analgesia and reducing visits to the Emergency Room (ER) for reasons other than PTH.",False,"Is the triple 'Methylprednisolone affects spinal cord injury' supported by the sentence: 'The Effect of Ibuprofen Dosing Interval on Post-Tonsillectomy Outcomes in Children: A Quality Improvement Study.OBJECTIVE: In this Quality Improvement (QI project) it was hypothesized that an increase in dosing intervals for postoperative analgesia when alternating Ibuprofen and Acetaminophen would reduce post-tonsillectomy hemorrhage (PTH) rates for those undergoing tonsillectomies with or without adenoidectomy, while maintaining the standard of postoperative analgesia and reducing visits to the Emergency Room (ER) for reasons other than PTH.'?","No, the statement does not provide any direct or indirect support for the claim that ""Methylprednisolone affects spinal cord injury."" The statement is about a Quality Improvement project examining the effect of Ibuprofen dosing intervals on post-tonsillectomy outcomes in children. The project does not mention Methylprednisolone nor spinal cord injuries at all, so it does not provide any relevant information concerning the effects of Methylprednisolone on spinal cord injuries." +10845505,Methylprednisolone affects Pain,57,Studies show that ibuprofen demonstrates superior efficacy in fever reduction compared to acetaminophen.,False,Is the triple 'Methylprednisolone affects Pain' supported by the sentence: 'Studies show that ibuprofen demonstrates superior efficacy in fever reduction compared to acetaminophen.'?,"No, the statement does not provide indirect support for the phrase ""Methylprednisolone affects Pain"". The statement compares the fever-reducing efficacy of ibuprofen and acetaminophen, which is not related to methylprednisolone or pain management. Methylprednisolone is a corticosteroid used primarily for its anti-inflammatory effects rather than pain reduction. While it might have some analgesic properties due to its anti-inflammatory action, it is not directly supported by the given statement about ibuprofen and acetaminophen in fever reduction." +10048898,Methylprednisolone affects ulcerative colitis,58,IV Ibuprofen for Prevention of Post-Ercp Pancreatitis in Children: A Randomized Placebo-Controlled Feasibility Study.,False,Is the triple 'Methylprednisolone affects ulcerative colitis' supported by the sentence: 'IV Ibuprofen for Prevention of Post-Ercp Pancreatitis in Children: A Randomized Placebo-Controlled Feasibility Study.'?,"No, the statement ""IV Ibuprofen for Prevention of Post-ERCP Pancreatitis in Children: A Randomized Placebo-Controlled Feasibility Study"" does not provide indirect support for the phrase ""Methylprednisolone affects ulcerative colitis."" The study focuses on using intravenous ibuprofen for preventing post-ERCP (Endoscopic Retrograde Cholangiopancreatography) pancreatitis in children; it does not involve methylprednisolone or ulcerative colitis in any way. Therefore, there is no connection between these two pieces of information that would allow for indirect support." +9646753,Methylprednisolone affects multiple sclerosis,59,Altitude Sickness Prevention with Ibuprofen Relative to Acetazolamide.,False,Is the triple 'Methylprednisolone affects multiple sclerosis' supported by the sentence: 'Altitude Sickness Prevention with Ibuprofen Relative to Acetazolamide.'?,"No, the statement ""Altitude Sickness Prevention with Ibuprofen Relative to Acetazolamide"" does not provide indirect support for the phrase ""Methylprednisolone affects multiple sclerosis."" + + The statement in question discusses altitude sickness prevention using Ibuprofen compared to Acetazolamide, which is unrelated to Multiple Sclerosis (MS) or Methylprednisolone. Methylprednisolone is a corticosteroid used in treating various conditions such as inflammation, allergic reactions, and MS relapses due to its immunosuppressive properties. + + While both Ibuprofen and Methylprednisolone have anti-inflammatory effects, they act through different mechanisms and have distinct therapeutic applications. Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) that inhibits cyclooxygenase (COX) enzymes involved in prostaglandin synthesis, whereas Methylprednisolone influences gene expression and suppresses immune cell function via gluc" +9346353,Methylprednisolone affects chronic obstructive pulmonary disease,60,"In conclusion, prednisone, ibuprofen and betamethasone may prevent OA by suppressing the expression of IL-6 and IL-8, subsequently inactivating NF-kappaB and STAT3 pathways, and ultimately, leading to decreased levels of collagen I, MMP-1, and MMP-13.",False,"Is the triple 'Methylprednisolone affects chronic obstructive pulmonary disease' supported by the sentence: 'In conclusion, prednisone, ibuprofen and betamethasone may prevent OA by suppressing the expression of IL-6 and IL-8, subsequently inactivating NF-kappaB and STAT3 pathways, and ultimately, leading to decreased levels of collagen I, MMP-1, and MMP-13.'?","No, the statement does not provide indirect support for the phrase ""Methylprednisolone affects chronic obstructive pulmonary disease"" (COPD). The statement discusses the effects of prednisone, ibuprofen, and betamethasone on osteoarthritis (OA) by suppressing specific pathways and decreasing levels of certain proteins involved in joint degradation. Methylprednisolone is not mentioned in the statement, nor is there any connection made between these medications/pathways/proteins and COPD. Therefore, it is inappropriate to infer any support for the given phrase based on this information alone." +9107378,Methylprednisolone affects Edema,61,"This study aims to determine the therapeutic effects of ibuprofen, diphenhydramine and aluminum magnesium simethicone (AlMgS) syrup on reducing oral aphthous ulcer pain.",False,"Is the triple 'Methylprednisolone affects Edema' supported by the sentence: 'This study aims to determine the therapeutic effects of ibuprofen, diphenhydramine and aluminum magnesium simethicone (AlMgS) syrup on reducing oral aphthous ulcer pain.'?","No, the statement does not provide indirect support for the claim that ""Methylprednisolone affects Edema"". The study mentioned is focused on determining the therapeutic effects of ibuprofen, diphenhydramine, and aluminum magnesium simethicone syrup on reducing oral aphthous ulcer pain. Methylprednisolone is not mentioned in the study aims, nor does it have any direct or indirect relation to ibuprofen, diphenhydramine, or aluminum magnesium simethicone syrup in terms of treating oral aphthous ulcers or reducing pain associated with them. Methylprednisolone is primarily used for its anti-inflammatory and immunosuppressive properties in various medical conditions, one of which is edema; however, this study does not investigate methylprednisolone or its effects on edema." +8596544,Methylprednisolone affects asthma,62,"CONCLUSIONS: Considering the results of the study, reflexology was superior to Ibuprofen on reducing dysmenorrhea and its treatment effect continued even after discontinuing the intervention in the third cycle.",False,"Is the triple 'Methylprednisolone affects asthma' supported by the sentence: 'CONCLUSIONS: Considering the results of the study, reflexology was superior to Ibuprofen on reducing dysmenorrhea and its treatment effect continued even after discontinuing the intervention in the third cycle.'?","No, the statement does not provide any indirect support for the claim that ""Methylprednisolone affects asthma."" The conclusion in the statement is about reflexology being superior to Ibuprofen in reducing dysmenorrhea, which is unrelated to Methylprednisolone or asthma treatment. The two statements involve different subjects (reflexology vs Methylprednisolone) and conditions (dysmenorrhea vs asthma), so there is no overlap that would allow for indirect support." +8330909,Methylprednisolone affects systemic lupus erythematosus,63,CONCLUSION: We conclude that pain therapy with an almost peripherally acting drug such as ibuprofen can reduce osteoporosis-associated chronic pain better than a centrally acting pain medication such as tramadol.,False,Is the triple 'Methylprednisolone affects systemic lupus erythematosus' supported by the sentence: 'CONCLUSION: We conclude that pain therapy with an almost peripherally acting drug such as ibuprofen can reduce osteoporosis-associated chronic pain better than a centrally acting pain medication such as tramadol.'?,"No, the conclusion does not provide indirect support for the statement that ""Methylprednisolone affects systemic lupus erythematosus"". The conclusion discusses the efficacy of two different types of pain medications (ibuprofen, a non-steroidal anti-inflammatory drug (NSAID), and tramadol, an opioid) in managing osteoporosis-associated chronic pain without mentioning methylprednisolone or systemic lupus erythematosus (SLE). Methylprednisolone is a corticosteroid used primarily for its potent anti-inflammatory effects in various diseases such as SLE but is not mentioned in the conclusion provided. Therefore, it does not offer any indirect support for the original statement about methylprednisolone affecting SLE." +19744632,Methylprednisolone disrupts Edema,64,The objective of this study was to determine whether pretreatment with ibuprofen would prevent the onset or decrease the severity of headache that occurs after ECT.,False,Is the triple 'Methylprednisolone disrupts Edema' supported by the sentence: 'The objective of this study was to determine whether pretreatment with ibuprofen would prevent the onset or decrease the severity of headache that occurs after ECT.'?,"No, the statement does not provide indirect support for the phrase ""Methylprednisolone disrupts Edema"". The study in question focuses on determining whether pretreatment with ibuprofen can prevent or decrease the severity of headaches following Electroconvulsive Therapy (ECT). Methylprednisolone is not mentioned in the statement at all, let alone in relation to edema disruption." +18407557,Methylprednisolone disrupts thrombocytopenia,65,The results of this study reveal that intake of ibuprofen can decrease muscle soreness induced after eccentric exercise but cannot assist in restoring muscle function.,False,Is the triple 'Methylprednisolone disrupts thrombocytopenia' supported by the sentence: 'The results of this study reveal that intake of ibuprofen can decrease muscle soreness induced after eccentric exercise but cannot assist in restoring muscle function.'?,"No, the statement does not provide indirect support for the phrase ""Methylprednisolone disrupts thrombocytopenia."" The study mentioned in the statement investigates the effects of ibuprofen on muscle soreness after exercise, not methylprednisolone or thrombocytopenia (a condition characterized by abnormally low levels of platelets in the blood). Therefore, the evidence provided does not pertain to methylprednisolone nor thrombocytopenia, making it irrelevant in supporting that claim. + + To provide indirect support for ""Methylprednisolone disrupts thrombocytopenia,"" one would need evidence suggesting that methylprednisolone has an impact on platelet function or levels in some capacity. This impact could either be positive (increasing platelet count) or negative (decreasing platelet count). However, without any reference or mention of methylprednisolone in the given statement, it cannot be used as indirect evidence for its effect on thrombocytopenia." +11106658,Methylprednisolone disrupts Pain,66,The objective of our study was to determine the role of ibuprofen in protecting neutropenic rats from cardiopulmonary injury due to endotoxemia.,False,Is the triple 'Methylprednisolone disrupts Pain' supported by the sentence: 'The objective of our study was to determine the role of ibuprofen in protecting neutropenic rats from cardiopulmonary injury due to endotoxemia.'?,"No, the statement does not provide indirect support for the phrase ""Methylprednisolone disrupts Pain."" The objective of the study mentioned is focused on investigating the protective effects of ibuprofen on neutropenic rats suffering from cardiopulmonary injury due to endotoxemia. Methylprednisolone is not mentioned in the statement; therefore, no conclusions can be drawn about its relationship with pain disruption based on this information alone." +8640603,Methylprednisolone disrupts Inflammation,67,"To determine if prophylactic etodolac would significantly reduce postendodontic pain, when compared with ibuprofen or placebo, 36 patients consented to single blind oral administration of either 400 mg of etodolac, 600 mg of ibuprofen, or a placebo, before conventional one-appointment root canal therapy.",False,"Is the triple 'Methylprednisolone disrupts Inflammation' supported by the sentence: 'To determine if prophylactic etodolac would significantly reduce postendodontic pain, when compared with ibuprofen or placebo, 36 patients consented to single blind oral administration of either 400 mg of etodolac, 600 mg of ibuprofen, or a placebo, before conventional one-appointment root canal therapy.'?","No, the statement does not provide indirect support for the phrase ""Methylprednisolone disrupts Inflammation"". The study mentioned in the statement investigates the effects of prophylactic etodolac, ibuprofen, and placebo on postendodontic pain but does not involve methylprednisolone. Therefore, it does not provide evidence or implications related to methylprednisolone disruption of inflammation." +23934495,Methylprednisolone prevents Cognitive impairment,68,UNLABELLED: The aim of our study was to evaluate whether the prophylactic use of ibuprofen would reduce the incidence of significant patent ductus arteriosus (PDA) and to confirm the effectiveness of ibuprofen as rescue treatment in closing PDA.,False,Is the triple 'Methylprednisolone prevents Cognitive impairment' supported by the sentence: 'UNLABELLED: The aim of our study was to evaluate whether the prophylactic use of ibuprofen would reduce the incidence of significant patent ductus arteriosus (PDA) and to confirm the effectiveness of ibuprofen as rescue treatment in closing PDA.'?,"No, the statement does not provide indirect support for the phrase ""Methylprednisolone prevents Cognitive impairment."" The focus of the study in the statement is on evaluating the prophylactic use of ibuprofen in reducing the incidence of significant patent ductus arteriosus (PDA) and its effectiveness as rescue treatment in closing PDA. Methylprednisolone is not mentioned in the study, so there is no basis for inferring any effect it may have on cognitive impairment." +20014108,Methylprednisolone prevents rheumatoid arthritis,69,"Nonsteroidal anti-inflammatory drugs (NSAIDs) such as aspirin, indomethacin and ibuprofen are the most widely used drugs for pain, arthritis, cardiovascular diseases and, more recently, the prevention of colon cancer and Alzheimer disease.",False,"Is the triple 'Methylprednisolone prevents rheumatoid arthritis' supported by the sentence: 'Nonsteroidal anti-inflammatory drugs (NSAIDs) such as aspirin, indomethacin and ibuprofen are the most widely used drugs for pain, arthritis, cardiovascular diseases and, more recently, the prevention of colon cancer and Alzheimer disease.'?","No, the statement does not provide indirect support for the phrase ""Methylprednisolone prevents rheumatoid arthritis"". The statement discusses Nonsteroidal anti-inflammatory drugs (NSAIDs) such as aspirin, indomethacin, and ibuprofen, which have a different mechanism of action and therapeutic effects compared to Methylprednisolone, a corticosteroid used for its anti-inflammatory and immunosuppressive effects in various conditions including rheumatoid arthritis treatment. While both NSAIDs and Methylprednisolone can be used in treating arthritis symptoms, they differ in their disease-modifying abilities and long-term effects on rheumatoid arthritis prevention." +18266414,Methylprednisolone prevents Abdominal pain,70,Aggravation of seizure-associated microvascular injuries by ibuprofen may involve multiple pathways.,False,Is the triple 'Methylprednisolone prevents Abdominal pain' supported by the sentence: 'Aggravation of seizure-associated microvascular injuries by ibuprofen may involve multiple pathways.'?,"No, the statement ""Aggravation of seizure-associated microvascular injuries by ibuprofen may involve multiple pathways"" does not provide indirect support for the claim that ""Methylprednisolone prevents Abdominal pain."" + + + + The two statements discuss different subjects: one focuses on methylprednisolone potentially preventing abdominal pain, while the other discusses ibuprofen potentially exacerbating seizure-associated microvascular injuries through various pathways. + + + + The provided statement about ibuprofen does not mention methylprednisolone nor abdominal pain; therefore, it does not contribute any evidence for or against that claim. + + + + To establish indirect support for the claim about methylprednisolone preventing abdominal pain, we would need evidence connecting ibuprofen usage (or another factor related to abdominal pain) with methylprednisolone treatment in some way that would suggest one affects the other. Since there is no such connection in the provided statement, it does not offer indirect support for the initial claim." +14967074,Methylprednisolone prevents asthma,71,"Use of paracetamol, ibuprofen or aspirin in pregnancy and risk of cerebral palsy in the child.",False,"Is the triple 'Methylprednisolone prevents asthma' supported by the sentence: 'Use of paracetamol, ibuprofen or aspirin in pregnancy and risk of cerebral palsy in the child.'?","No, the statement ""Methylprednisolone prevents asthma"" does not receive indirect support from ""Use of paracetamol, ibuprofen or aspirin in pregnancy and risk of cerebral palsy in the child."" + + These two statements discuss entirely different subjects: one pertains to methylprednisolone as a preventative treatment for asthma, while the other discusses medication use during pregnancy and its potential impact on cerebral palsy risk in offspring. There is no overlap in terms of shared variables, concepts, or mechanisms that would allow for indirect support from one statement to be drawn from the other in any meaningful way. + + In order for there to be indirect support between these two statements, there would need to be some connection in terms of shared factors such as an implicated biological pathway, common risk factors, demonstrated efficacy in similar patient populations, etc., but none exists here based on the information provided." +9744990,Methylprednisolone prevents ovarian hyperstimulation syndrome,72,"More than two cycles of ibuprofen was significantly associated with an increased risk for bronchopulmonary dysplasia (odds ratio [OR], 2.81; p = 0.03) and acute renal failure (OR, 3.81; p = 0.09).",False,"Is the triple 'Methylprednisolone prevents ovarian hyperstimulation syndrome' supported by the sentence: 'More than two cycles of ibuprofen was significantly associated with an increased risk for bronchopulmonary dysplasia (odds ratio [OR], 2.81; p = 0.03) and acute renal failure (OR, 3.81; p = 0.09).'?","No, the statement does not provide indirect support for the claim that methylprednisolone prevents ovarian hyperstimulation syndrome (OHSS). The statement discusses the association between repeated cycles of ibuprofen use in infants and an increased risk for bronchopulmonary dysplasia and acute renal failure. There is no mention of methylprednisolone or ovarian hyperstimulation syndrome in this statement. In order for there to be indirect support for the claim about methylprednisolone preventing OHSS, there would need to be some connection between methylprednisolone, ibuprofen, or their respective effects on ovarian hyperstimulation syndrome or bronchopulmonary dysplasia/acute renal failure, but no such connection is evident in this statement." +8345063,Methylprednisolone prevents Pain,73,OBJECTIVE: Non-steroidal anti-inflammatory drugs such as ibuprofen have a protective role on risk of Alzheimer's disease (AD).,False,Is the triple 'Methylprednisolone prevents Pain' supported by the sentence: 'OBJECTIVE: Non-steroidal anti-inflammatory drugs such as ibuprofen have a protective role on risk of Alzheimer's disease (AD).'?,"No, the statement does not provide indirect support for the phrase ""Methylprednisolone prevents Pain"". The objective in question discusses non-steroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen, having a protective role against Alzheimer's disease (AD). Methylprednisolone is a glucocorticoid steroid medication used primarily for its anti-inflammatory effects in various conditions; however, it is not classified as an NSAID nor is there any mention of pain prevention in the provided statement. + + To provide indirect support for ""Methylprednisolone prevents Pain"", one would need a statement linking methylprednisolone to pain prevention through its anti-inflammatory properties or some other mechanism. The lack of connection between methylprednisolone and pain prevention in the given statement makes it an unsuitable basis for inferring support for that phrase." +8291272,Methylprednisolone prevents graft versus host disease,74,"There seems to be a marked gradient of risk for acute kidney injury across agents, specifically for indomethacin, ibuprofen, and rofecoxib.",False,"Is the triple 'Methylprednisolone prevents graft versus host disease' supported by the sentence: 'There seems to be a marked gradient of risk for acute kidney injury across agents, specifically for indomethacin, ibuprofen, and rofecoxib.'?","No, the statement does not provide indirect support for the phrase ""Methylprednisolone prevents graft versus host disease."" The statement discusses the risk gradient for acute kidney injury across different non-steroidal anti-inflammatory drugs (NSAIDs) such as indomethacin, ibuprofen, and rofecoxib. Methylprednisolone is a corticosteroid and not an NSAID; therefore, it is not relevant to the discussion of NSAID-induced kidney injury risk. The statement does not mention graft versus host disease (GvHD) at all; thus, it does not provide any support for the claim that methylprednisolone prevents GvHD." +7980138,Methylprednisolone prevents spinal cord injury,75,"Significant heterogeneity was present for the NSAIDs; e.g., ibuprofen was associated with an increased overall fracture risk (OR = 2.09, 95% CI 2.00-2.18 for <20 DDD), while celecoxib was not (OR = 0.76, 95% CI 0.51-1.13 for <20 DDD, 2P < 0.01 for comparison).",False,"Is the triple 'Methylprednisolone prevents spinal cord injury' supported by the sentence: 'Significant heterogeneity was present for the NSAIDs; e.g., ibuprofen was associated with an increased overall fracture risk (OR = 2.09, 95% CI 2.00-2.18 for <20 DDD), while celecoxib was not (OR = 0.76, 95% CI 0.51-1.13 for <20 DDD, 2P < 0.01 for comparison).'?","No, the statement does not provide indirect support for the phrase ""Methylprednisolone prevents spinal cord injury"". The provided information discusses the relationship between nonsteroidal anti-inflammatory drugs (NSAIDs), specifically ibuprofen and celecoxib, and overall fracture risk. Methylprednisolone is a corticosteroid drug used primarily for its anti-inflammatory effects in various medical conditions; it is different from NSAIDs in terms of its mechanism of action and side effects profile. + + The two statements discuss different drugs and different outcomes (spinal cord injury vs fracture risk), so they do not provide any relevant information supporting or contradicting each other. In order for there to be indirect support between these two statements, they would need to share some commonalities in terms of drug class, mechanism of action, study design, population, or outcome measure; however, that is not the case here. + + To assess whether methylprednisolone prevents spinal cord injury, one would need to examine studies specifically investigating its effects in spinal cord injury models, ideally through randomized controlled trials or" +7414405,Methylprednisolone prevents Edema,76,One should be more critical about ivabradine and low-dose digoxin in diastolic heart failure.,False,Is the triple 'Methylprednisolone prevents Edema' supported by the sentence: 'One should be more critical about ivabradine and low-dose digoxin in diastolic heart failure.'?,"No, the statement ""One should be more critical about ivabradine and low-dose digoxin in diastolic heart failure"" does not provide indirect support for the claim that ""Methylprednisolone prevents Edema."" + + The two statements discuss different drugs (Methylprednisolone vs ivabradine and low-dose digoxin) and their potential effects on different conditions (Edema vs diastolic heart failure). The second statement is cautioning against using certain medications for diastolic heart failure without being overly critical, but it does not imply that Methylprednisolone is effective in preventing Edema. + + To provide indirect support, there should be some connection between the two statements in terms of shared concepts or ideas that would allow one statement to lend credence to another. In this case, there is no such connection between Methylprednisolone and Edema on one hand, and ivabradine, low-dose digoxin, and diastolic heart failure on the other hand." +18106042,Methylprednisolone predisposes pneumonia,77,"Preclinical studies of ivabradine in animal models with induced AF demonstrated a reduction in HR, with no significant worsening of QT interval or mean arterial pressure.",False,"Is the triple 'Methylprednisolone predisposes pneumonia' supported by the sentence: 'Preclinical studies of ivabradine in animal models with induced AF demonstrated a reduction in HR, with no significant worsening of QT interval or mean arterial pressure.'?","No, the statement does not provide indirect support for the phrase ""Methylprednisolone predisposes pneumonia."" The statement discusses preclinical studies on ivabradine, its effects on heart rate (HR), QT interval, and mean arterial pressure in animal models with atrial fibrillation (AF). There is no mention of methylprednisolone or pneumonia in the statement, making it unrelated to the claim in question." +9645180,Methylprednisolone predisposes Inflammation,78,"In this review, we summarize the current knowledge of the HCN4 channel and ivabradine, including the function of HCN4 in cardiac pacemaking, the mechanism of action of If inhibition by ivabradine, and the pharmacological and clinical effects of ivabradine in cardiac diseases as HF, coronary artery disease, and atrial fibrillation.",False,"Is the triple 'Methylprednisolone predisposes Inflammation' supported by the sentence: 'In this review, we summarize the current knowledge of the HCN4 channel and ivabradine, including the function of HCN4 in cardiac pacemaking, the mechanism of action of If inhibition by ivabradine, and the pharmacological and clinical effects of ivabradine in cardiac diseases as HF, coronary artery disease, and atrial fibrillation.'?","No, the statement does not provide any direct or indirect support for the phrase ""Methylprednisolone predisposes Inflammation."" The statement is a review on the HCN4 channel, its function in cardiac pacemaking, the mechanism of action of If inhibition by ivabradine, and the pharmacological and clinical effects of ivabradine in certain cardiac diseases. It does not mention Methylprednisolone or its potential relationship with inflammation." +12905337,Cefotaxime related to Sepsis,79,Small studies have recently investigated the role of ivabradine in MS in sinus rhythm.,False,Is the triple 'Cefotaxime related to Sepsis' supported by the sentence: 'Small studies have recently investigated the role of ivabradine in MS in sinus rhythm.'?,"No, the statement ""Small studies have recently investigated the role of ivabradine in MS in sinus rhythm"" does not provide any direct or indirect support for the phrase ""Cefotaxime related to Sepsis"". + + The two statements discuss different subjects: one is about ivabradine's potential role in treating Multiple Sclerosis (MS) in sinus rhythm, while the other connects Cefotaxime with sepsis. There is no overlap in terms of substances, conditions, or concepts that would allow for indirect support to be inferred. + + To establish a connection between Cefotaxime and sepsis, one could look at existing literature on antibiotics like Cefotaxime and their association with sepsis, but that would require separate evidence beyond what was provided in your question." +24475300,Cefotaxime affects bacterial infectious disease,80,The role of Ivabradine in Diastolic Heart Failure with preserved Ejection Fraction.,False,Is the triple 'Cefotaxime affects bacterial infectious disease' supported by the sentence: 'The role of Ivabradine in Diastolic Heart Failure with preserved Ejection Fraction.'?,"No, the statement ""Cefotaxime affects bacterial infectious disease"" does not receive any direct or indirect support from the phrase ""The role of Ivabradine in Diastolic Heart Failure with preserved Ejection Fraction."" These two statements discuss different topics: antibiotic treatment for bacterial infections (Cefotaxime) vs. treatment for diastolic heart failure (Ivabradine). + + To better understand why there is no connection between these two statements, let us consider their components separately: + + 1. ""Cefotaxime affects bacterial infectious disease"" - This statement implies that Cefotaxime has an impact on bacterial infectious diseases by either inhibiting bacterial growth (as an antibiotic) or altering the course of infection in some other way. + + 2. ""The role of Ivabradine in Diastolic Heart Failure with preserved Ejection Fraction"" - This statement concerns Ivabradine, which is used primarily for treating heart conditions such as heart failure (with reduced ejection fraction) and irregular heartbeats (arrhythmias). The phrase specifically highlights diastolic heart failure with preserved ejection fraction as" +23922029,Cefotaxime affects Sepsis,81,"Other large trials are also underway to assess the effects of ivabradine on heart failure, acute coronary syndromes, CAD, and other cardiovascular disorders.",False,"Is the triple 'Cefotaxime affects Sepsis' supported by the sentence: 'Other large trials are also underway to assess the effects of ivabradine on heart failure, acute coronary syndromes, CAD, and other cardiovascular disorders.'?","No, the phrase ""Cefotaxime affects Sepsis"" does not receive indirect support from the statement: ""Other large trials are also underway to assess the effects of ivabradine on heart failure, acute coronary syndromes, CAD, and other cardiovascular disorders."" + + The statement provided discusses ongoing clinical trials investigating the effects of ivabradine on various cardiovascular conditions such as heart failure, acute coronary syndromes (ACS), coronary artery disease (CAD), and other related disorders. Cefotaxime is an antibiotic used primarily for treating severe bacterial infections like sepsis; it does not have any direct relation to ivabradine or any cardiovascular conditions mentioned in the statement. + + Since there is no connection between Cefotaxime and sepsis mentioned in the statement nor any reference made that would imply an indirect relationship between Cefotaxime and sepsis through ivabradine or any cardiovascular condition, we cannot infer support for the claim that ""Cefotaxime affects Sepsis"" from the provided statement." +18672205,Cefotaxime affects peritonitis,82,"Other large trials are also underway to assess the effects of ivabradine on heart failure, acute coronary syndromes, CAD, and other cardiovascular disorders.",False,"Is the triple 'Cefotaxime affects peritonitis' supported by the sentence: 'Other large trials are also underway to assess the effects of ivabradine on heart failure, acute coronary syndromes, CAD, and other cardiovascular disorders.'?","No, the statement does not provide any direct or indirect support for the phrase ""Cefotaxime affects peritonitis."" The two statements discuss different topics: one is about Cefotaxime (an antibiotic) and its potential impact on peritonitis (inflammation of the peritoneum), while the other is about ivabradine (a medication for heart failure) and its potential effects on various cardiovascular disorders. + + However, it is important to note that if there were any existing studies that show Cefotaxime has an effect on peritonitis, then it would provide indirect support for the idea that Cefotaxime affects peritonitis. But in this case, no such connection is made in either statement provided." +15853591,Cefotaxime prevents Sepsis,83,Effective suppression of atrial fibrillation by ivabradine: Novel target for an established drug?,False,Is the triple 'Cefotaxime prevents Sepsis' supported by the sentence: 'Effective suppression of atrial fibrillation by ivabradine: Novel target for an established drug?'?,"No, the statement ""Effective suppression of atrial fibrillation by ivabradine: Novel target for an established drug"" does not provide indirect support for the phrase ""Cefotaxime prevents Sepsis."" These two statements discuss different drugs (Cefotaxime and Ivabradine) and different medical conditions (Sepsis and Atrial Fibrillation). Since there is no overlap between these concepts in terms of drug or condition, there is no indirect support provided by one statement for the other claim. + + To further clarify, Cefotaxime is an antibiotic used for treating various bacterial infections, including sepsis (bloodstream infections). Meanwhile, Ivabradine is used for treating certain heart conditions like atrial fibrillation (irregular heartbeat) by slowing down the heart rate without affecting its contractility. + + Therefore, it is essential to evaluate each claim based on their specific evidence and context without drawing unfounded connections between unrelated statements or concepts in order to maintain accuracy in analyzing scientific information." +19081412,Ceftriaxone prevents bacterial infectious disease,84,[SIGNIFY study is a disappointment. Ivabradine cannot stop of the progression of coronary heart disease].,False,Is the triple 'Ceftriaxone prevents bacterial infectious disease' supported by the sentence: '[SIGNIFY study is a disappointment. Ivabradine cannot stop of the progression of coronary heart disease].'?,"No, the statement ""Ceftriaxone prevents bacterial infectious disease"" does not receive indirect support from the given statement about the SIGNIFY study and ivabradine's inability to stop coronary heart disease progression. Ceftriaxone is an antibiotic used for treating bacterial infections while ivabradine is a drug used for treating certain heart conditions; hence they belong to different therapeutic categories without any direct connection between them that would provide indirect support for Ceftriaxone preventing bacterial infectious disease based on the SIGNIFY study results on ivabradine and coronary heart disease progression." +25827448,Gefarnate related to gastric ulcer,85,RESULTS: Heart rate reduction and prevention of postoperative AF or tachyarrhythmia with combined therapy was more effective than with metoprolol or ivabradine alone during the immediate postoperative management of cardiac surgery patients.,False,Is the triple 'Gefarnate related to gastric ulcer' supported by the sentence: 'RESULTS: Heart rate reduction and prevention of postoperative AF or tachyarrhythmia with combined therapy was more effective than with metoprolol or ivabradine alone during the immediate postoperative management of cardiac surgery patients.'?,"No, the statement does not provide any direct or indirect support for the phrase ""Gefarnate related to gastric ulcer"". The result provided in the statement is about heart rate reduction and prevention of postoperative atrial fibrillation (AF) or tachyarrhythmia in cardiac surgery patients using combined therapy compared to metoprolol or ivabradine alone during immediate postoperative management. There is no mention or implication of Gefarnate or gastric ulcer in the statement." +24296137,Gefarnate related to duodenal ulcer,86,"During exercise, ivabradine dose dependently and significantly reduced the exercise-induced tachycardia (-17, -21, and -32% at 0.25, 0.5, and 1 mg/kg, respectively, versus saline) without altering myocardial contractility nor mean ejection wall stress.",False,"Is the triple 'Gefarnate related to duodenal ulcer' supported by the sentence: 'During exercise, ivabradine dose dependently and significantly reduced the exercise-induced tachycardia (-17, -21, and -32% at 0.25, 0.5, and 1 mg/kg, respectively, versus saline) without altering myocardial contractility nor mean ejection wall stress.'?","No, the statement does not provide indirect support for the phrase ""Gefarnate related to duodenal ulcer."" The statement discusses the effects of ivabradine on heart rate and cardiac function during exercise in rats but does not mention gefarnate or duodenal ulcers. Gefarnate is an antithrombotic drug used for preventing blood clots, while duodenal ulcers are sores in the lining of the duodenum, typically caused by bacterial infections or long-term use of nonsteroidal anti-inflammatory drugs (NSAIDs). + + To establish a relationship between gefarnate and duodenal ulcers, one would need evidence linking gefarnate use to an increased risk of duodenal ulcers or evidence suggesting that gefarnate has therapeutic effects on duodenal ulcers. The provided statement does not contain any information relevant to these connections." +25993651,Gefarnate disrupts gastric ulcer,87,Recent trials reported that risk of atrial fibrillation (AF) is increased in patients using ivabradine compared with controls.,False,Is the triple 'Gefarnate disrupts gastric ulcer' supported by the sentence: 'Recent trials reported that risk of atrial fibrillation (AF) is increased in patients using ivabradine compared with controls.'?,"No, the statement does not provide indirect support for the phrase ""Gefarnate disrupts gastric ulcer"". The two statements discuss different subjects: one is about a drug (Gefarnate) potentially affecting gastric ulcers and the other is about another drug (ivabradine) increasing the risk of atrial fibrillation (AF). There is no connection between these two distinct drugs or conditions that would allow us to infer any relationship between them based on these statements alone." +17758516,Neobiotic related to Inflammation,88,Randomized comparative study of cefixime versus cephalexin in acute bacterial exacerbations of chronic bronchitis.,False,Is the triple 'Neobiotic related to Inflammation' supported by the sentence: 'Randomized comparative study of cefixime versus cephalexin in acute bacterial exacerbations of chronic bronchitis.'?,"No, the phrase ""Neobiotic related to Inflammation"" does not receive direct or indirect support from the statement: ""Randomized comparative study of cefixime versus cephalexin in acute bacterial exacerbations of chronic bronchitis."" + + The statement describes a randomized comparative study between two antibiotics (cefixime and cephalexin) in treating acute bacterial exacerbations of chronic bronchitis. There is no mention or implication of neobiotics (newly introduced microorganisms) in relation to inflammation within this context. + + Neobiotics typically refer to microorganisms that have been recently introduced into an environment—often in the context of probiotics or other microbiome-altering interventions—rather than antibiotics used for treating bacterial infections. Therefore, there is no connection between neobiotics and inflammation in this particular study statement." +10690423,Neobiotic related to burn,89,Alterations of the pilQ gene in Neisseria gonorrhoeae are unlikely contributors to decreased susceptibility to ceftriaxone and cefixime in clinical gonococcal strains.,False,Is the triple 'Neobiotic related to burn' supported by the sentence: 'Alterations of the pilQ gene in Neisseria gonorrhoeae are unlikely contributors to decreased susceptibility to ceftriaxone and cefixime in clinical gonococcal strains.'?,"No, the statement does not provide indirect support for the phrase ""Neobiotic related to burn"". The statement discusses alterations of the pilQ gene in Neisseria gonorrhoeae and their relationship to antibiotic resistance, specifically ceftriaxone and cefixime. A neobiotic is a term that refers to an entirely new form of life created through synthetic biology, which is unrelated to burns or antibiotic resistance in Neisseria gonorrhoeae. Therefore, there is no connection between the two statements." +20263460,Neobiotic affects neoplasm,90,"Because of the emergence of these bacteria, other antimicrobial agents, both old and new, have been advocated for treatment and prevention of otitis media; amoxicillin-clavulanate, cefuroxime axetil, and cefixime are the newer agents.",False,"Is the triple 'Neobiotic affects neoplasm' supported by the sentence: 'Because of the emergence of these bacteria, other antimicrobial agents, both old and new, have been advocated for treatment and prevention of otitis media; amoxicillin-clavulanate, cefuroxime axetil, and cefixime are the newer agents.'?","No, the statement does not provide indirect support for the phrase ""Neobiotic affects neoplasm."" The provided statement discusses antibiotics used for treating otitis media (middle ear infection), while the phrase in question refers to an effect on neoplasm (abnormal tissue growth that can lead to cancer). Although both involve medical interventions, they refer to different biological processes and conditions, so there is no logical connection between them based on the provided information." +19744068,Neobiotic affects Inflammation,91,Experimental comparison of protective characteristics of enalapril and trimetazidine in diabetic nephropathy.,False,Is the triple 'Neobiotic affects Inflammation' supported by the sentence: 'Experimental comparison of protective characteristics of enalapril and trimetazidine in diabetic nephropathy.'?,"No, the statement ""Experimental comparison of protective characteristics of enalapril and trimetazidine in diabetic nephropathy"" does not provide direct or indirect support for the phrase ""Neobiotic affects Inflammation."" The statement discusses an experimental comparison between two drugs (enalapril and trimetazidine) in the context of diabetic nephropathy without mentioning neobiotics or inflammation. + + A neobiotic refers to an artificial organism created through genetic engineering techniques (synthetic biology), which is not mentioned in the given statement. Moreover, while diabetic nephropathy is associated with inflammation, no causal link is established between neobiotics and inflammation in this statement. + + To provide indirect support for ""Neobiotic affects Inflammation,"" there would need to be some connection between neobiotics and inflammation in the statement; however, no such connection exists here." +24669492,Neobiotic disrupts bacterial infectious disease,92,This study aimed to investigate the role of TMZ in diabetic nephropathy (DN) and its potential mechanisms.,False,Is the triple 'Neobiotic disrupts bacterial infectious disease' supported by the sentence: 'This study aimed to investigate the role of TMZ in diabetic nephropathy (DN) and its potential mechanisms.'?,"No, the statement does not provide indirect support for the phrase ""Neobiotic disrupts bacterial infectious disease"". The study mentioned in the statement investigates the role of TMZ in diabetic nephropathy (DN) and its potential mechanisms. TMZ is an antidiabetic drug, not a neobiotic (an antibiotic substance produced by a living organism). Therefore, there is no connection between the statement and the phrase in question." +17119153,Neobiotic disrupts neoplasm,93,Objective: This study investigates the effect of TMZ in sunitinib-induced cardiotoxicity in vivo and in vitro and molecular mechanisms.,False,Is the triple 'Neobiotic disrupts neoplasm' supported by the sentence: 'Objective: This study investigates the effect of TMZ in sunitinib-induced cardiotoxicity in vivo and in vitro and molecular mechanisms.'?,"No, the phrase ""Neobiotic disrupts neoplasm"" does not receive indirect support from the statement provided. + + The statement is about an investigation into the effect of a specific chemotherapeutic drug, temozolomide (TMZ), on sunitinib-induced cardiotoxicity in both in vivo (live organisms) and in vitro (outside an organism) settings. The study also explores molecular mechanisms associated with these effects. + + A neobiotic refers to a newly introduced species into an ecosystem; it is not related to chemotherapeutic drugs like TMZ. A neoplasm is another term for a tumor or abnormal growth; it is not directly related to cardiotoxicity or the molecular mechanisms being studied in this context. Therefore, there is no indirect support for the phrase ""Neobiotic disrupts neoplasm"" in the given statement." +26428369,Neobiotic prevents bacterial infectious disease,94,The role of trimetazidine in cardiovascular disease: beyond an anti-anginal agent.,False,Is the triple 'Neobiotic prevents bacterial infectious disease' supported by the sentence: 'The role of trimetazidine in cardiovascular disease: beyond an anti-anginal agent.'?,"No, the statement ""The role of trimetazidine in cardiovascular disease: beyond an anti-anginal agent"" does not provide indirect support for the phrase ""Neobiotic prevents bacterial infectious disease."" The two statements discuss different areas of medicine - cardiovascular disease and bacterial infectious disease - without any overlap in subject matter related to neobiotics preventing bacterial infections." +25579460,BLINATUMOMAB related to Precursor B-Cell Lymphoblastic Leukemia-Lymphoma,95,"Trimetazidine, 2.5 mg/kg/day i.p. for 3 days before doxorubicin administration plus 2.5 mg/kg/day p.o. for 10 weeks, was unable to prevent the development of doxorubicin-induced long-term cardiotoxicity.",False,"Is the triple 'BLINATUMOMAB related to Precursor B-Cell Lymphoblastic Leukemia-Lymphoma' supported by the sentence: 'Trimetazidine, 2.5 mg/kg/day i.p. for 3 days before doxorubicin administration plus 2.5 mg/kg/day p.o. for 10 weeks, was unable to prevent the development of doxorubicin-induced long-term cardiotoxicity.'?","No, the statement does not provide indirect support for the connection between BLINATUMOMAB and Precursor B-Cell Lymphoblastic Leukemia-Lymphoma. The statement discusses Trimetazidine's inability to prevent long-term cardiotoxicity induced by Doxorubicin, which is unrelated to BLINATUMOMAB and Precursor B-Cell Lymphoblastic Leukemia-Lymphoma." +22474123,BLINATUMOMAB related to hematopoietic and lymphoid system neoplasm,96,Ranolazine was more effective than lidocaine in terminating persistent AF and in preventing the induction of AF.,False,Is the triple 'BLINATUMOMAB related to hematopoietic and lymphoid system neoplasm' supported by the sentence: 'Ranolazine was more effective than lidocaine in terminating persistent AF and in preventing the induction of AF.'?,"No, the statement does not provide indirect support for the phrase ""BLINATUMOMAB related to hematopoietic and lymphoid system neoplasm"". The statement discusses two pharmaceutical drugs (ranolazine and lidocaine) in relation to persistent atrial fibrillation (AF), but it does not mention BLINATUMOMAB nor any hematopoietic and lymphoid system neoplasms. BLINATUMOMAB is an immunotherapy used for treating certain types of leukemia and lymphoma, which are cancers affecting blood-forming tissues in the hematopoietic and lymphoid system (1). The provided statement does not offer any connection between these distinct areas of medical science. + + Reference: + 1) National Cancer Institute (2021). Blinatumomab. Retrieved from https://www.cancer.gov/about-cancer/treatment/drugs/blinatumomab" +21947892,BLINATUMOMAB related to acute lymphoblastic leukemia,97,Role of Ranolazine in cardiovascular disease and diabetes: Exploring beyond angina.,False,Is the triple 'BLINATUMOMAB related to acute lymphoblastic leukemia' supported by the sentence: 'Role of Ranolazine in cardiovascular disease and diabetes: Exploring beyond angina.'?,"No, the statement ""Role of Ranolazine in cardiovascular disease and diabetes: Exploring beyond angina"" does not provide indirect support for the phrase ""BLINATUMOMAB related to acute lymphoblastic leukemia"". + + The statement is about Ranolazine, its role in cardiovascular disease and diabetes, and explores its potential uses beyond angina. This is unrelated to BLINATUMOMAB, which is a bispecific T-cell engager (BiTE) antibody construct used for treating acute lymphoblastic leukemia (ALL). The two subjects—Ranolazine in cardiovascular disease/diabetes and BLINATUMOMAB in ALL—are distinct areas of medical research and do not share any significant commonalities that would allow for indirect support between them." +27155094,Ciprofloxacin related to endophthalmitis,98,"Furthermore, the activated Akt/mTOR signaling pathway induced by AF was further activated by ranolazine.",False,"Is the triple 'Ciprofloxacin related to endophthalmitis' supported by the sentence: 'Furthermore, the activated Akt/mTOR signaling pathway induced by AF was further activated by ranolazine.'?","No, the statement does not provide indirect support for the phrase ""Ciprofloxacin related to endophthalmitis."" The two statements discuss different topics: one refers to Akt/mTOR signaling pathway activation by aminofluoridine (AF) and ranolazine, while the other connects Ciprofloxacin to endophthalmitis. There is no overlap or connection between these subjects in the provided information." +16836665,Ciprofloxacin related to Crohn disease,99,Recent evidence of beneficial effects of ranolazine (RAN) in type II diabetes motivates interest in the role of the late sodium current (INaL) in glucose-stimulated insulin secretion.,False,Is the triple 'Ciprofloxacin related to Crohn disease' supported by the sentence: 'Recent evidence of beneficial effects of ranolazine (RAN) in type II diabetes motivates interest in the role of the late sodium current (INaL) in glucose-stimulated insulin secretion.'?,"No, the statement does not provide indirect support for the connection between Ciprofloxacin and Crohn disease. The statement discusses the potential link between ranolazine (RAN) and type II diabetes through its influence on glucose-stimulated insulin secretion via late sodium current (INaL). The drugs Ciprofloxacin and ranolazine have different mechanisms of action and therapeutic indications; Ciprofloxacin is an antibiotic used primarily for treating bacterial infections while ranolazine is used for treating angina. + + Additionally, there is no explicit or implicit reference made in the statement that relates Ciprofloxacin or Crohn disease. The evidence provided in the statement is specific to ranolazine and type II diabetes; therefore, it does not support any conclusions regarding Ciprofloxacin and Crohn disease." +19572117,Ciprofloxacin related to DNA Gyrase,100,Effect of ranolazine in preventing postoperative atrial fibrillation in patients undergoing coronary revascularization surgery.,False,Is the triple 'Ciprofloxacin related to DNA Gyrase' supported by the sentence: 'Effect of ranolazine in preventing postoperative atrial fibrillation in patients undergoing coronary revascularization surgery.'?,"No, the statement ""Effect of ranolazine in preventing postoperative atrial fibrillation in patients undergoing coronary revascularization surgery"" does not provide indirect support for the phrase ""Ciprofloxacin related to DNA Gyrase."" + + The reason is that these two phrases discuss unrelated topics. The first statement pertains to ranolazine's effect on preventing postoperative atrial fibrillation in patients undergoing coronary revascularization surgery. In contrast, the second phrase refers to ciprofloxacin's relationship with DNA gyrase. Ciprofloxacin is an antibiotic that inhibits bacterial DNA gyrase, thereby inhibiting DNA replication and transcription in bacteria; however, ranolazine is a medication used primarily for treating chronic angina. + + Therefore, there is no meaningful connection between these two phrases in terms of subject matter, mechanisms, or implications that would allow one statement to indirectly support the other." \ No newline at end of file