diff --git a/pkgs/by-name/me/mesen/deps.json b/pkgs/by-name/me/mesen/deps.json
new file mode 100644
index 0000000000000..8b22846368733
--- /dev/null
+++ b/pkgs/by-name/me/mesen/deps.json
@@ -0,0 +1,272 @@
+[
+ {
+ "pname": "Avalonia",
+ "version": "11.2.0",
+ "hash": "sha256-kG3tnsLdodlvIjYd5feBZ0quGd2FsvV8FIy7uD5UZ5Q="
+ },
+ {
+ "pname": "Avalonia.Angle.Windows.Natives",
+ "version": "2.1.22045.20230930",
+ "hash": "sha256-RxPcWUT3b/+R3Tu5E5ftpr5ppCLZrhm+OTsi0SwW3pc="
+ },
+ {
+ "pname": "Avalonia.AvaloniaEdit",
+ "version": "11.1.0",
+ "hash": "sha256-K9+hK+4aK93dyuGytYvVU25daz605+KN54hmwQYXFF8="
+ },
+ {
+ "pname": "Avalonia.BuildServices",
+ "version": "0.0.29",
+ "hash": "sha256-WPHRMNowRnYSCh88DWNBCltWsLPyOfzXGzBqLYE7tRY="
+ },
+ {
+ "pname": "Avalonia.Controls.ColorPicker",
+ "version": "11.2.0",
+ "hash": "sha256-x6IdcSo3e2Pq/En9/N80HpPblEXSAv51VRlBrF8wlVM="
+ },
+ {
+ "pname": "Avalonia.Controls.DataGrid",
+ "version": "11.2.0",
+ "hash": "sha256-pd/cD82onMZ0iMLl9TOCl35PEvAPbyX2lUj49lrBpOA="
+ },
+ {
+ "pname": "Avalonia.Controls.ProportionalStackPanel",
+ "version": "11.2.0",
+ "hash": "sha256-Y8tX7dBzSl69NOSNdpNGzGetc6wQtKnFy/KRnV0SKhQ="
+ },
+ {
+ "pname": "Avalonia.Controls.Recycling",
+ "version": "11.2.0",
+ "hash": "sha256-ylsPhtILO0pk+5uPZKB5L1o7X8JTiOe48czPPLYLyVs="
+ },
+ {
+ "pname": "Avalonia.Controls.Recycling.Model",
+ "version": "11.2.0",
+ "hash": "sha256-zAleY6ryWIexJAzz4BpT/Xd3iDgNL624YW5sIBJ0Sv8="
+ },
+ {
+ "pname": "Avalonia.Desktop",
+ "version": "11.2.0",
+ "hash": "sha256-+5ISi6WXe8AIjClVo3UqZHgzZpFbMgFk13YvHHhx9MM="
+ },
+ {
+ "pname": "Avalonia.Diagnostics",
+ "version": "11.2.0",
+ "hash": "sha256-k60HGDKnsXiDOnxSH+Hx2ihyqmxSSeWIBJx2XD1ELW0="
+ },
+ {
+ "pname": "Avalonia.FreeDesktop",
+ "version": "11.2.0",
+ "hash": "sha256-u4CQvG6EdsyaHSWa+Y704sDiWZlqbArB0g4gcoCFwQo="
+ },
+ {
+ "pname": "Avalonia.MarkupExtension",
+ "version": "11.2.0",
+ "hash": "sha256-BUEMX+YThWmxh9X50bGsFtclLFVSIITMlAf0iq2vApk="
+ },
+ {
+ "pname": "Avalonia.Native",
+ "version": "11.2.0",
+ "hash": "sha256-fMikurP2RAnOahZkORxuGOKGn5iQ0saZCEYsvoFiFQI="
+ },
+ {
+ "pname": "Avalonia.ReactiveUI",
+ "version": "11.2.0",
+ "hash": "sha256-6GXX1ZA6gS9CpkQnGepx1PFNoKiwcHQyLSK5qOGmjYo="
+ },
+ {
+ "pname": "Avalonia.Remote.Protocol",
+ "version": "11.2.0",
+ "hash": "sha256-QwYY3bpShJ1ayHUx+mjnwaEhCPDzTk+YeasCifAtGzM="
+ },
+ {
+ "pname": "Avalonia.Skia",
+ "version": "11.2.0",
+ "hash": "sha256-rNR+l+vLtlzTU+F51FpOi4Ujy7nR5+lbTc3NQte8s/o="
+ },
+ {
+ "pname": "Avalonia.Themes.Fluent",
+ "version": "11.2.0",
+ "hash": "sha256-Ate6KC61pwXmTAk5h1uh7rjwAViuiO/qgAVMl3F1BA8="
+ },
+ {
+ "pname": "Avalonia.Themes.Simple",
+ "version": "11.2.0",
+ "hash": "sha256-l88ZX50Nao8wjtRnyZxNFFgRpJ/yxxNki6NY48dyTUg="
+ },
+ {
+ "pname": "Avalonia.Win32",
+ "version": "11.2.0",
+ "hash": "sha256-A9PB6Bt61jLdQlMOkchWy/3BwROgxS9BP8FObs/KFiU="
+ },
+ {
+ "pname": "Avalonia.X11",
+ "version": "11.2.0",
+ "hash": "sha256-EP9cCqriEh8d+Wwyv27QGK/CY6w2LcCjtcIv79PZqkM="
+ },
+ {
+ "pname": "CommunityToolkit.Mvvm",
+ "version": "8.0.0",
+ "hash": "sha256-G+PXrc2sr2pdy+JCr3t/Ge6nTDtuoWf1Eypu5HufAxw="
+ },
+ {
+ "pname": "Dock.Avalonia",
+ "version": "11.2.0",
+ "hash": "sha256-Q8YUsH+hfnL9VDMPTJSAms7xb+hr42p7scWqu2c2eD4="
+ },
+ {
+ "pname": "Dock.Model",
+ "version": "11.2.0",
+ "hash": "sha256-+PSgjxvHIJBQRn8naGgSfYyArImVLwy6ftm9FoQc+lA="
+ },
+ {
+ "pname": "Dock.Model.Mvvm",
+ "version": "11.2.0",
+ "hash": "sha256-iO67eWHoxsB51Wx5KIK4dwVkU9qwrja7pYsQWTs/8sA="
+ },
+ {
+ "pname": "Dock.Settings",
+ "version": "11.2.0",
+ "hash": "sha256-esCRl7Trdv2bu2ayLw5kXVtCskXLar1asykkfWnqhug="
+ },
+ {
+ "pname": "DotNet.Bundle",
+ "version": "0.9.13",
+ "hash": "sha256-VA7wFPC2V4JudQ+edk6lFkklDPIHZYVWql8/KMzcnys="
+ },
+ {
+ "pname": "DynamicData",
+ "version": "8.3.27",
+ "hash": "sha256-iPZfL1x36PLf5Lq96zRFvR5OLcoRn7OdJIao98X8wac="
+ },
+ {
+ "pname": "DynamicData",
+ "version": "8.4.1",
+ "hash": "sha256-r+haH5VlmZFJTEJ3UedsYybw+oddn/CSvfm6x7PrrQ4="
+ },
+ {
+ "pname": "ELFSharp",
+ "version": "2.17.3",
+ "hash": "sha256-8OaAkLxpa5rIhxbmDSnKLeY06jS7nV66LjBjXxHnOb0="
+ },
+ {
+ "pname": "Fody",
+ "version": "6.8.0",
+ "hash": "sha256-2laYscz0i0LalGTAup7dsh6XlYRZSojYpp8XOwZJJfg="
+ },
+ {
+ "pname": "HarfBuzzSharp",
+ "version": "7.3.0.2",
+ "hash": "sha256-ibgoqzT1NV7Qo5e7X2W6Vt7989TKrkd2M2pu+lhSDg8="
+ },
+ {
+ "pname": "HarfBuzzSharp.NativeAssets.Linux",
+ "version": "7.3.0.2",
+ "hash": "sha256-SSfyuyBaduGobJW+reqyioWHhFWsQ+FXa2Gn7TiWxrU="
+ },
+ {
+ "pname": "HarfBuzzSharp.NativeAssets.macOS",
+ "version": "7.3.0.2",
+ "hash": "sha256-dmEqR9MmpCwK8AuscfC7xUlnKIY7+Nvi06V0u5Jff08="
+ },
+ {
+ "pname": "HarfBuzzSharp.NativeAssets.WebAssembly",
+ "version": "7.3.0.3-preview.2.2",
+ "hash": "sha256-1NlcTnXrWUYZ2r2/N3SPxNIjNcyIpiiv3g7h8XxpNkM="
+ },
+ {
+ "pname": "HarfBuzzSharp.NativeAssets.Win32",
+ "version": "7.3.0.2",
+ "hash": "sha256-x4iM3NHs9VyweG57xA74yd4uLuXly147ooe0mvNQ8zo="
+ },
+ {
+ "pname": "MicroCom.Runtime",
+ "version": "0.11.0",
+ "hash": "sha256-VdwpP5fsclvNqJuppaOvwEwv2ofnAI5ZSz2V+UEdLF0="
+ },
+ {
+ "pname": "ReactiveUI",
+ "version": "19.5.41",
+ "hash": "sha256-FsdD1lBZyegqOVzJhZHAz1owCLh7GbVUYXiORbo5euk="
+ },
+ {
+ "pname": "ReactiveUI",
+ "version": "20.1.1",
+ "hash": "sha256-p9l2GMzBRchKb4gW9pQ3DIKhs2O9fX3t/V7jDDztBqE="
+ },
+ {
+ "pname": "ReactiveUI.Fody",
+ "version": "19.5.41",
+ "hash": "sha256-LfKELxAfApQLL0fDd7UJCsZML5C4MFN+Gc5ECaBXmUM="
+ },
+ {
+ "pname": "SkiaSharp",
+ "version": "2.88.8",
+ "hash": "sha256-rD5gc4SnlRTXwz367uHm8XG5eAIQpZloGqLRGnvNu0A="
+ },
+ {
+ "pname": "SkiaSharp.NativeAssets.Linux",
+ "version": "2.88.8",
+ "hash": "sha256-fOmNbbjuTazIasOvPkd2NPmuQHVCWPnow7AxllRGl7Y="
+ },
+ {
+ "pname": "SkiaSharp.NativeAssets.macOS",
+ "version": "2.88.8",
+ "hash": "sha256-CdcrzQHwCcmOCPtS8EGtwsKsgdljnH41sFytW7N9PmI="
+ },
+ {
+ "pname": "SkiaSharp.NativeAssets.WebAssembly",
+ "version": "2.88.8",
+ "hash": "sha256-GWWsE98f869LiOlqZuXMc9+yuuIhey2LeftGNk3/z3w="
+ },
+ {
+ "pname": "SkiaSharp.NativeAssets.Win32",
+ "version": "2.88.8",
+ "hash": "sha256-b8Vb94rNjwPKSJDQgZ0Xv2dWV7gMVFl5GwTK/QiZPPM="
+ },
+ {
+ "pname": "Splat",
+ "version": "14.8.12",
+ "hash": "sha256-9KTsYPHVN/wiL8/Yy1KQafrFRy7x8VCEHdzgB+9+8SU="
+ },
+ {
+ "pname": "Splat",
+ "version": "15.1.1",
+ "hash": "sha256-WipAVaUx2HrYNQ9LcYm496LndmSpVbuzJxzP9FA6Ohg="
+ },
+ {
+ "pname": "System.ComponentModel.Annotations",
+ "version": "5.0.0",
+ "hash": "sha256-0pST1UHgpeE6xJrYf5R+U7AwIlH3rVC3SpguilI/MAg="
+ },
+ {
+ "pname": "System.IO.Pipelines",
+ "version": "8.0.0",
+ "hash": "sha256-LdpB1s4vQzsOODaxiKstLks57X9DTD5D6cPx8DE1wwE="
+ },
+ {
+ "pname": "System.Reactive",
+ "version": "6.0.0",
+ "hash": "sha256-hXB18OsiUHSCmRF3unAfdUEcbXVbG6/nZxcyz13oe9Y="
+ },
+ {
+ "pname": "System.Reactive",
+ "version": "6.0.1",
+ "hash": "sha256-Lo5UMqp8DsbVSUxa2UpClR1GoYzqQQcSxkfyFqB/d4Q="
+ },
+ {
+ "pname": "System.Text.Encodings.Web",
+ "version": "8.0.0",
+ "hash": "sha256-IUQkQkV9po1LC0QsqrilqwNzPvnc+4eVvq+hCvq8fvE="
+ },
+ {
+ "pname": "System.Text.Json",
+ "version": "8.0.0",
+ "hash": "sha256-XFcCHMW1u2/WujlWNHaIWkbW1wn8W4kI0QdrwPtWmow="
+ },
+ {
+ "pname": "Tmds.DBus.Protocol",
+ "version": "0.20.0",
+ "hash": "sha256-CRW/tkgsuBiBJfRwou12ozRQsWhHDooeP88E5wWpWJw="
+ }
+]
diff --git a/pkgs/by-name/me/mesen/dont-use-alternative-restore-sources.patch b/pkgs/by-name/me/mesen/dont-use-alternative-restore-sources.patch
new file mode 100644
index 0000000000000..1c194a4a3084f
--- /dev/null
+++ b/pkgs/by-name/me/mesen/dont-use-alternative-restore-sources.patch
@@ -0,0 +1,16 @@
+diff --git a/UI/UI.csproj b/UI/UI.csproj
+index 2a0eb78..74751bc 100644
+--- a/UI/UI.csproj
++++ b/UI/UI.csproj
+@@ -90,11 +90,6 @@
+
+
+
+-
+-
+- https://nuget-feed-nightly.avaloniaui.net/v3/index.json;https://api.nuget.org/v3/index.json
+-
+-
+
+
+
diff --git a/pkgs/by-name/me/mesen/dont-zip-libraries.patch b/pkgs/by-name/me/mesen/dont-zip-libraries.patch
new file mode 100644
index 0000000000000..6aeed6c3e757f
--- /dev/null
+++ b/pkgs/by-name/me/mesen/dont-zip-libraries.patch
@@ -0,0 +1,74 @@
+diff --git a/UI/Config/ConfigManager.cs b/UI/Config/ConfigManager.cs
+index 56c1ff1..ed5fe8a 100644
+--- a/UI/Config/ConfigManager.cs
++++ b/UI/Config/ConfigManager.cs
+@@ -51,7 +51,6 @@ namespace Mesen.Config
+ } else {
+ homeFolder = DefaultDocumentsFolder;
+ }
+- Program.ExtractNativeDependencies(homeFolder);
+ _homeFolder = homeFolder;
+ Config.Save();
+ }
+diff --git a/UI/Program.cs b/UI/Program.cs
+index dfc4ba3..632cef2 100644
+--- a/UI/Program.cs
++++ b/UI/Program.cs
+@@ -54,8 +54,6 @@ namespace Mesen
+ Environment.CurrentDirectory = ConfigManager.HomeFolder;
+
+ if(!File.Exists(ConfigManager.GetConfigFile())) {
+- //Could not find configuration file, show wizard
+- ExtractNativeDependencies(ConfigManager.HomeFolder);
+ App.ShowConfigWindow = true;
+ BuildAvaloniaApp().StartWithClassicDesktopLifetime(args, ShutdownMode.OnMainWindowClose);
+ if(File.Exists(ConfigManager.GetConfigFile())) {
+@@ -68,9 +66,6 @@ namespace Mesen
+ //Start loading config file in a separate thread
+ Task.Run(() => ConfigManager.LoadConfig());
+
+- //Extract core dll & other native dependencies
+- ExtractNativeDependencies(ConfigManager.HomeFolder);
+-
+ if(CommandLineHelper.IsTestRunner(args)) {
+ return TestRunner.Run(args);
+ }
+@@ -147,7 +142,7 @@ namespace Mesen
+ libraryName = libraryName + ".dylib";
+ }
+ }
+- return NativeLibrary.Load(Path.Combine(ConfigManager.HomeFolder, libraryName));
++ return NativeLibrary.Load(Path.Combine(AppContext.BaseDirectory, libraryName));
+ }
+ return IntPtr.Zero;
+ }
+diff --git a/UI/UI.csproj b/UI/UI.csproj
+index 053d495..2a0eb78 100644
+--- a/UI/UI.csproj
++++ b/UI/UI.csproj
+@@ -634,7 +634,6 @@
+
+
+
+-
+
+
+
+@@ -644,16 +643,5 @@
+
+
+
+-
+-
+-
+-
+-
+-
+-
+-
+-
+-
+-
+
+
+
diff --git a/pkgs/by-name/me/mesen/package.nix b/pkgs/by-name/me/mesen/package.nix
new file mode 100644
index 0000000000000..43957a1c7004a
--- /dev/null
+++ b/pkgs/by-name/me/mesen/package.nix
@@ -0,0 +1,82 @@
+{
+ lib,
+ clangStdenv,
+ buildDotnetModule,
+ dotnetCorePackages,
+ fetchFromGitHub,
+ wrapGAppsHook3,
+ gtk3,
+ SDL2,
+}:
+
+buildDotnetModule rec {
+ pname = "mesen";
+ version = "2.0.0-unstable-2024-12-25";
+
+ src = fetchFromGitHub {
+ owner = "SourMesen";
+ repo = "Mesen2";
+ rev = "6820db37933002089a04d356d8469481e915a359";
+ hash = "sha256-TzGMZr351XvVj/wARWJxRisRb5JlkyzdjCVYbwydBVE=";
+ };
+
+ patches = [
+ # the nightly avalonia repository url is still queried, which errors out
+ # even if we don't actually need any nightly versions
+ ./dont-use-alternative-restore-sources.patch
+ # upstream has a weird library loading mechanism, which we override with a more sane alternative
+ ./dont-zip-libraries.patch
+ ];
+
+ dotnet-sdk = dotnetCorePackages.sdk_8_0;
+ dotnet-runtime = dotnetCorePackages.runtime_8_0;
+
+ projectFile = [ "UI/UI.csproj" ];
+
+ dotnetFlags = [
+ "-p:RuntimeIdentifier=${dotnetCorePackages.systemToDotnetRid clangStdenv.hostPlatform.system}"
+ ];
+
+ executables = [ "Mesen" ];
+
+ nugetDeps = ./deps.json;
+
+ nativeBuildInputs = [ wrapGAppsHook3 ];
+
+ runtimeDeps = [ gtk3 ];
+
+ postInstall = ''
+ ln -s ${passthru.core}/lib/MesenCore.* $out/lib/mesen
+ '';
+
+ # according to upstream, compiling with clang creates a faster binary
+ passthru.core = clangStdenv.mkDerivation {
+ pname = "mesen-core";
+ inherit version src;
+
+ enableParallelBuilding = true;
+
+ strictDeps = true;
+
+ nativeBuildInputs = [ SDL2 ];
+
+ buildInputs = [ SDL2 ];
+
+ makeFlags = [ "core" ];
+
+ installPhase = ''
+ runHook preInstall
+ install -Dm755 InteropDLL/obj.*/MesenCore.* -t $out/lib
+ runHook postInstall
+ '';
+ };
+
+ meta = {
+ badPlatforms = [ "aarch64-linux" ]; # not sure what the issue is
+ description = "Multi-system emulator that supports NES, SNES, Game Boy (Color) and PC Engine games";
+ homepage = "https://www.mesen.ca";
+ license = lib.licenses.gpl3Plus;
+ mainProgram = "Mesen";
+ maintainers = with lib.maintainers; [ tomasajt ];
+ };
+}