diff --git a/.github/workflows/tests.yaml b/.github/workflows/tests.yaml
new file mode 100644
index 0000000..a9a0f3c
--- /dev/null
+++ b/.github/workflows/tests.yaml
@@ -0,0 +1,59 @@
+name: "CI"
+on:
+  # on PR to main
+  pull_request:
+    branches:
+      - main
+  # on push to main
+  push:
+    branches:
+      - main
+
+concurrency:
+  group: ${{ github.workflow }}-${{ github.ref }}
+  cancel-in-progress: true
+
+  defaults:
+    run:
+      shell: bash -l {0}
+
+jobs:
+  tests:
+    runs-on: ${{ matrix.os }}
+    name: "${{ matrix.os }} python-${{ matrix.python-version }}"
+    strategy:
+      fail-fast: false
+      matrix:
+        os: [ubuntu-latest, macos-latest]
+        python-version:
+          - 3.10
+          - 3.11
+          - 3.12
+    steps:
+      - uses: actions/checkout@v4
+        with:
+          fetch-depth: 0
+
+      - name: Setup micromamba
+        uses: mamba-org/setup-micromamba@v2
+        with:
+          environment-name: stratocaster-test
+          init-shell: bash
+          cache-environment: true
+          # Since gufe the single dependency, install it without env file
+          create-args: >-
+            python=${{ matrix.python-version }}
+            gufe
+
+      - name: Install stratocaster
+        # install test dependencies
+        run: python -m pip install -e ".[test]"
+
+      - name: Environment information
+        run: |
+          micromamba info
+          micromamba list
+
+      - name: Run tests
+        run: |
+          pytest -v src/stratocaster/tests/