diff --git a/common/changes/@visactor/vchart/fix-region-foreground-event_2025-01-07-07-02.json b/common/changes/@visactor/vchart/fix-region-foreground-event_2025-01-07-07-02.json
new file mode 100644
index 0000000000..54a04a78fd
--- /dev/null
+++ b/common/changes/@visactor/vchart/fix-region-foreground-event_2025-01-07-07-02.json
@@ -0,0 +1,10 @@
+{
+  "changes": [
+    {
+      "packageName": "@visactor/vchart",
+      "comment": "fix: fix invisible region blocking mark events, #3638",
+      "type": "none"
+    }
+  ],
+  "packageName": "@visactor/vchart"
+}
\ No newline at end of file
diff --git a/packages/vchart/src/region/region.ts b/packages/vchart/src/region/region.ts
index 9664bb243a..1cd6fd8791 100644
--- a/packages/vchart/src/region/region.ts
+++ b/packages/vchart/src/region/region.ts
@@ -213,7 +213,8 @@ export class Region<T extends IRegionSpec = IRegionSpec> extends LayoutModel<T>
         this._foregroundMark,
         {
           ...this._spec.style,
-          fillOpacity: 0
+          fillOpacity: 0,
+          pickable: false
         },
         'normal',
         AttributeLevel.User_Mark