diff --git a/README.md b/README.md
index 112dc021d..6035d4f44 100644
--- a/README.md
+++ b/README.md
@@ -255,6 +255,8 @@ Currently documentation is available for the following pipelines within specific
 - ampliseq
   - [BINAC](docs/pipeline/ampliseq/binac.md)
   - [UPPMAX](docs/pipeline/ampliseq/uppmax.md)
+- cutandrun
+  - [UNC_LONGLEAF](docs/pipeline/cutandrun/unc_longleaf.md)
 - demultiplex
   - [AWS_TOWER](docs/pipeline/demultiplex/aws_tower.md)
 - eager
diff --git a/docs/pipeline/cutandrun/unc_longleaf.md b/docs/pipeline/cutandrun/unc_longleaf.md
new file mode 100644
index 000000000..2b8f6e860
--- /dev/null
+++ b/docs/pipeline/cutandrun/unc_longleaf.md
@@ -0,0 +1,22 @@
+# nf-core/configs: UNC's Longleaf CUT&RUN specific configuration
+
+Extra specific configuration for eager pipeline
+
+## Pipeline specific profiles
+
+Specific-pipeline profiles exist for the following pipelines, and will be automatically loaded when supplying `-profile unc_longleaf` to your command:
+
+- cutandrun
+
+## Usage
+
+To use, run the pipeline with `-profile unc_longleaf`.
+
+This will download and launch the eager specific [`unc_longleaf.config`](../../../conf/pipeline/cutandrun/unc_longleaf.config) which is adapted to data generated at UNC-CH and
+processed on the Longleaf HPC.
+
+Example: `nextflow run nf-core/cutandrun -profile unc_longleaf`
+
+### Specifics
+
+This custom config adds extra memory to the FRAG_LEN_HIST and DEEPTOOLS_PLOTHEATMAP_GENE_ALL as the jobs kept failing with default memory limits
diff --git a/pipeline/cutandrun.config b/pipeline/cutandrun.config
new file mode 100644
index 000000000..126e506c0
--- /dev/null
+++ b/pipeline/cutandrun.config
@@ -0,0 +1,13 @@
+/*
+    * ------------------------------------------------------
+    *  nfcore/cutandrun custom profile Nextflow config file
+    * ------------------------------------------------------
+    * Config options for custom environments.
+    * Cluster-specific config options should be saved
+    * in the conf/pipeline/cutandrun folder and imported
+    * under a profile name here.
+    */
+
+profiles {
+    unc_longleaf { includeConfig "${params.custom_config_base}/conf/pipeline/cutandrun/unc_longleaf.config" }
+}