diff --git a/README.md b/README.md
index 5595a41..4a86251 100644
--- a/README.md
+++ b/README.md
@@ -550,6 +550,7 @@ Both can coexist with standard Tag parsing.
 | `and:"X,Y,..."`      | AND groups for flags. All flags in the group must be used in the same command. When combined with `required`, all flags in the group will be required.                                                                                                                                                                         |
 | `prefix:"X"`         | Prefix for all sub-flags.                                                                                                                                                                                                                                                                                                      |
 | `envprefix:"X"`      | Envar prefix for all sub-flags.                                                                                                                                                                                                                                                                                                |
+| `xorprefix:"X"`      | Prefix for all sub-flags in XOR/AND groups.                                                                                                                                                                                                                                                                                  |
 | `set:"K=V"`          | Set a variable for expansion by child elements. Multiples can occur.                                                                                                                                                                                                                                                           |
 | `embed:""`           | If present, this field's children will be embedded in the parent. Useful for composition.                                                                                                                                                                                                                                      |
 | `passthrough:"<mode>"`[^1] | If present on a positional argument, it stops flag parsing when encountered, as if `--` was processed before. Useful for external command wrappers, like `exec`. On a command it requires that the command contains only one argument of type `[]string` which is then filled with everything following the command, unparsed. |
diff --git a/build.go b/build.go
index 166935b..228c0e9 100644
--- a/build.go
+++ b/build.go
@@ -71,6 +71,7 @@ func flattenedFields(v reflect.Value, ptag *Tag) (out []flattenedField, err erro
 		// Accumulate prefixes.
 		tag.Prefix = ptag.Prefix + tag.Prefix
 		tag.EnvPrefix = ptag.EnvPrefix + tag.EnvPrefix
+		tag.XorPrefix = ptag.XorPrefix + tag.XorPrefix
 		// Combine parent vars.
 		tag.Vars = ptag.Vars.CloneWith(tag.Vars)
 		// Command and embedded structs can be pointers, so we hydrate them now.
@@ -111,7 +112,7 @@ func flattenedFields(v reflect.Value, ptag *Tag) (out []flattenedField, err erro
 // Build a Node in the Kong data model.
 //
 // "v" is the value to create the node from, "typ" is the output Node type.
-func buildNode(k *Kong, v reflect.Value, typ NodeType, tag *Tag, seenFlags map[string]bool) (*Node, error) {
+func buildNode(k *Kong, v reflect.Value, typ NodeType, tag *Tag, seenFlags map[string]bool) (*Node, error) { //nolint:gocyclo
 	node := &Node{
 		Type:   typ,
 		Target: v,
@@ -147,6 +148,12 @@ MAIN:
 			}
 		}
 
+		if len(tag.Xor) != 0 {
+			for i := range tag.Xor {
+				tag.Xor[i] = tag.XorPrefix + tag.Xor[i]
+			}
+		}
+
 		// Nested structs are either commands or args, unless they implement the Mapper interface.
 		if field.value.Kind() == reflect.Struct && (tag.Cmd || tag.Arg) && k.registry.ForValue(fv) == nil {
 			typ := CommandNode
diff --git a/kong_test.go b/kong_test.go
index 66ad847..2f3ab47 100644
--- a/kong_test.go
+++ b/kong_test.go
@@ -2475,3 +2475,23 @@ func TestCustomTypeNoEllipsis(t *testing.T) {
 	help := w.String()
 	assert.NotContains(t, help, "...")
 }
+
+func TestPrefixXorIssue343(t *testing.T) {
+	type DBConfig struct {
+		Password        string `help:"Password" xor:"password" optional:""`
+		PasswordFile    string `help:"File which content will be used for a password" xor:"password" optional:""`
+		PasswordCommand string `help:"Command to run to retrieve password" xor:"password" optional:""`
+	}
+
+	type SourceTargetConfig struct {
+		Source DBConfig `help:"Database config of source to be copied from" prefix:"source-" xorprefix:"source-" embed:""`
+		Target DBConfig `help:"Database config of source to be copied from" prefix:"target-" xorprefix:"target-" embed:""`
+	}
+
+	cli := SourceTargetConfig{}
+	kctx := mustNew(t, &cli)
+	_, err := kctx.Parse([]string{"--source-password=foo", "--target-password=bar"})
+	assert.NoError(t, err)
+	_, err = kctx.Parse([]string{"--source-password-file=foo", "--source-password=bar"})
+	assert.Error(t, err)
+}
diff --git a/tag.go b/tag.go
index 226171b..a2bc4a9 100644
--- a/tag.go
+++ b/tag.go
@@ -48,6 +48,7 @@ type Tag struct {
 	Vars            Vars
 	Prefix          string // Optional prefix on anonymous structs. All sub-flags will have this prefix.
 	EnvPrefix       string
+	XorPrefix       string // Optional prefix on XOR/AND groups.
 	Embed           bool
 	Aliases         []string
 	Negatable       string
@@ -268,6 +269,7 @@ func hydrateTag(t *Tag, typ reflect.Type) error { //nolint: gocyclo
 	}
 	t.Prefix = t.Get("prefix")
 	t.EnvPrefix = t.Get("envprefix")
+	t.XorPrefix = t.Get("xorprefix")
 	t.Embed = t.Has("embed")
 	if t.Has("negatable") {
 		if !isBool && !isBoolPtr {