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We discuss software infrastructure for databank operations of the c-VEDA project.

Recruitment and acquisition centres

The c-VEDA project is an accelerated longitudinal study. Participants are organized into 3 age bands which may be administered different instruments:

Age band ID	Age band name	Age range
C1	Children	6-11
C2	Adolescents	12-17
C3	Adults	18-23

The multiple recruitment and acquisition centres represent the socio-cultural diversity of India:

• 6 geographical regions
  • Punjab and adjoining states (CHANDIGARH)
  • Eastearn Coalfields (KOLKATA)
  • Northeast India (MANIPUR)
  • Mumbai (MUMBAI)
  • Bengaluru & Mysore (MYSORE, NIMHANS, SJRI)
  • Chittoor (RISHIVALLEY)
• urban and rural areas

ID	CENTRE	Site	Location	MRI
11	CHANDIGARH	Postgraduate Institute of Medical Education & Research	Chandigarh, Punjab	Siemens Verio
12	MANIPUR	Regional Institute of Medical Sciences	Imphal, Manipur	—
13	KOLKATA	Regional Occupational Health Centre (Eastern), Indian Council of Medical Research	Kolkata, West Bengal	Siemens Trio
14	RISHIVALLEY	Rishi Valley Rural Health Centre	Rishy Valley, Andhra Pradesh	—
15	MYSORE	CSI Holdsworth Memorial Hospital	Mysuru, Karnataka	Philips Ingenia
16	NIMHANS	NIMHANS	Bengaluru, Karnataka	Siemens Skyra / Philips Ingenia
17	SJRI	St. John's Research Institute	Bengaluru, Karnataka	—
18	MUMBAI	Centre for the Study of Social Change	Mumbai, Maharashtra	—

From acquisition centres to databank

• Acquisition centres collect clinical and environmental data using Psytools. The databank team download CSV files pseudonymized with PSC1 codes directly from the Delosis server.
• Acquisition centres pseudonymize biological samples at the source using PSC1 codes. The c-VEDA biobank team collect samples and collate genetic data before sending them to the databank.
• Acquisition centres anonymize DICOM files before sending them to the databank. Again subjects are identified by their PSC1 code only.

Databank operations

System software has been installed on the c-VEDA server as described in file /cveda/databank/framework/INSTALL.txt.

Application software has been deployed on the c-VEDA server under /cveda/databank/framework/cveda_databank:

cd /cveda/databank/framework
git clone https://github.com/cveda/cveda_databank.git

Databank operations, based on the above application software, are described in specific pages:

• Pseudonymization: generate PSC1 and PSC2 codes.
• Psytools: download and anonymize Psytools questionnaires from Delosis servers.
• Neuroimaging: collect and process MRI data from acquisition centres.