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Draw regional association plots #3

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dariushghasemi opened this issue Nov 21, 2024 · 1 comment
Open

Draw regional association plots #3

dariushghasemi opened this issue Nov 21, 2024 · 1 comment

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@dariushghasemi
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We use standalone locusZoom tool to generate the regional association plots at each locus of pQTL signals.

@dariushghasemi
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The rule is now able to create locusZoom plot with a the user-defined LD pattern for the target SNP in the region.
As teh wildcard is defined on seqid, we had plenty of steps to do:

  • we opened locus breaker results for each seqid,
  • we took region coordinates and top SNP of the region from locus breaker results,
  • meta-analysis results are based on METAL, we used tabix to extract the region of the locus from GWAS file and feed it to locusZoom standalone tool
  • finally, since LZ standalone tool could not remove the temporary folders for each locus, we remove the output file path from the prefix of the oputput files.
  • then, we save them in the main directory.

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