From 20bd3cca095858c91f93c0136a72776b0a03001f Mon Sep 17 00:00:00 2001 From: j1c Date: Mon, 15 Apr 2024 18:10:16 -0400 Subject: [PATCH] skeleton --- docs/lab-2024-04/lab-2024-04.md | 82 +++++++++++++++++++++++++++++++++ 1 file changed, 82 insertions(+) diff --git a/docs/lab-2024-04/lab-2024-04.md b/docs/lab-2024-04/lab-2024-04.md index 3d1a8ee..6850812 100644 --- a/docs/lab-2024-04/lab-2024-04.md +++ b/docs/lab-2024-04/lab-2024-04.md @@ -25,3 +25,85 @@ _Johns Hopkins University - Biomedical Engineering_ ![bg right:45% w:450](./../images/logos/nd_logo_small.png) --- + +# Outline + +1. What is fMRI? +2. How fMRI Works +3. fMRI Applications +4. Data processing + +--- + +# What is fMRI? + +--- + +# How fMRI Works + +--- + +# fMRI Applications + +fMRI is widely used to study: +Cognitive processes (memory, language, decision-making) +Sensory and motor functions +Brain development +Neurological and psychiatric conditions + +--- + +# Resting-State fMRI + +Subjects are asked to stay still and relaxed, often with their eyes closed. +fMRI scans measure the brain activity that occurs naturally at rest. +Functional connectivity analyses reveal intrinsic brain networks present even without a specific task. + +--- + +# What is Functional Connectivity? + +Functional connectivity examines how different brain regions are temporally correlated. +Regions that fluctuate in activity together are considered functionally 'connected.' +This reflects networks of brain areas working in concert. + +--- + +# Functional Connectivity Applications + +Mapping healthy brain networks +Investigating brain development across the lifespan +Identifying network changes in neurological and psychiatric conditions +Potential for clinical diagnosis and tracking treatment effectiveness + +--- + +# Yeo Networks + +The Yeo 7 Networks are a commonly used brain parcellation scheme based on resting-state functional MRI (fMRI) data. They represent seven major functional networks in the human brain, associated with different cognitive processes. Here's a basic breakdown: + +Visual Network: Processes visual information. +Somatomotor Network: Involved in sensory processing and motor control. +Dorsal Attention Network: Associated with top-down attention, directing focus towards specific stimuli. +Ventral Attention Network: Related to reorienting attention to unexpected or salient events. +Limbic Network: Involved in emotion processing and memory. +Frontoparietal Network: Important for flexible cognitive control, decision making, and working memory. +Default Mode Network: Engaged during internal thought, self-reflection, and mind-wandering. + +--- + +# How were the Yeo 7 Networks estimated? + +The Yeo 7 Networks were derived from a large-scale study involving resting-state fMRI data from 1,000 healthy individuals. Here's the general process: + +Data Preprocessing: fMRI data was carefully cleaned and preprocessed to remove noise and artifacts. +Functional Connectivity Analysis: Researchers calculated correlations in brain activity (blood oxygen level fluctuations as measured by fMRI ) across different regions of the brain over time. Areas showing synchronized patterns of activity were considered functionally connected. + +--- + +# Limitations + +fMRI measures blood flow (an indirect measure of neural activity) +Temporal resolution is relatively low (seconds) compared to the speed of brain processes (milliseconds). + +- Participants have to lie completely still while in an fMRI.