- DNMT3L connects unmethylated lysine 4 of histone H3 to de novo methylation of DNA (Ooi 2007)
- Dnmt3L is repelled by H3K4me3
- Dnmt3L recognizes histone H3 tails that are unmethylated at lysine 4 and induces de novo DNA methylation by recruitment or activation of DNMT3A2