diff --git a/journals/2024_11_18.md b/journals/2024_11_18.md
new file mode 100644
index 0000000..e69de29
diff --git a/logseq/config.edn b/logseq/config.edn
new file mode 100644
index 0000000..2de2694
--- /dev/null
+++ b/logseq/config.edn
@@ -0,0 +1,424 @@
+{:meta/version 1
+
+ ;; Set the preferred format.
+ ;; Available options:
+ ;; - Markdown (default)
+ ;; - Org
+ ;; :preferred-format "Markdown"
+
+ ;; Set the preferred workflow style.
+ ;; Available options:
+ ;; - :now for NOW/LATER style (default)
+ ;; - :todo for TODO/DOING style
+ :preferred-workflow :now
+
+ ;; Exclude directories/files.
+ ;; Example usage:
+ ;; :hidden ["/archived" "/test.md" "../assets/archived"]
+ :hidden []
+
+ ;; Define the default journal page template.
+ ;; Enter the template name between the quotes.
+ :default-templates
+ {:journals ""}
+
+ ;; Set a custom date format for the journal page title.
+ ;; Default value: "MMM do, yyyy"
+ ;; e.g., "Jan 19th, 2038"
+ ;; Example usage e.g., "Tue 19th, Jan 2038"
+ ;; :journal/page-title-format "EEE do, MMM yyyy"
+
+ ;; Specify the journal filename format using a valid date format string.
+ ;; !Warning:
+ ;;   This configuration is not retroactive and affects only new journals.
+ ;;   To show old journal files in the app, manually rename the files in the
+ ;;   journal directory to match the new format.
+ ;; Default value: "yyyy_MM_dd"
+ ;; :journal/file-name-format "yyyy_MM_dd"
+
+ ;; Enable tooltip preview on hover.
+ ;; Default value: true
+ :ui/enable-tooltip? true
+
+ ;; Display brackets [[]] around page references.
+ ;; Default value: true
+ ;; :ui/show-brackets? true
+
+ ;; Display all lines of a block when referencing ((block)).
+ ;; Default value: false
+ :ui/show-full-blocks? false
+
+ ;; Automatically expand block references when zooming in.
+ ;; Default value: true
+ :ui/auto-expand-block-refs? true
+
+ ;; Enable Block timestamps.
+ ;; Default value: false
+ :feature/enable-block-timestamps? false
+
+ ;; Disable accent marks when searching.
+ ;; After changing this setting, rebuild the search index by pressing (^C ^S).
+ ;; Default value: true
+ :feature/enable-search-remove-accents? true
+
+ ;; Enable journals.
+ ;; Default value: true
+ ;; :feature/enable-journals? true
+
+ ;; Enable flashcards.
+ ;; Default value: true
+ ;; :feature/enable-flashcards? true
+
+ ;; Enable whiteboards.
+ ;; Default value: true
+ ;; :feature/enable-whiteboards? true
+
+ ;; Disable the journal's built-in 'Scheduled tasks and deadlines' query.
+ ;; Default value: false
+ ;; :feature/disable-scheduled-and-deadline-query? false
+
+ ;; Specify the number of days displayed in the future for
+ ;; the 'scheduled tasks and deadlines' query.
+ ;; Example usage:
+ ;; Display all scheduled and deadline blocks for the next 14 days:
+ ;; :scheduled/future-days 14
+ ;; Default value: 7
+ ;; :scheduled/future-days 7
+
+ ;; Specify the first day of the week.
+ ;; Available options:
+ ;;  - integer from 0 to 6 (Monday to Sunday)
+ ;; Default value: 6 (Sunday)
+ :start-of-week 6
+
+ ;; Specify a custom CSS import.
+ ;; This option takes precedence over the local `logseq/custom.css` file.
+ ;; Example usage:
+ ;; :custom-css-url "@import url('https://cdn.jsdelivr.net/gh/dracula/logseq@master/custom.css');"
+
+ ;; Specify a custom JS import.
+ ;; This option takes precedence over the local `logseq/custom.js` file.
+ ;; Example usage:
+ ;; :custom-js-url "https://cdn.logseq.com/custom.js"
+
+ ;; Set a custom Arweave gateway
+ ;; Default gateway: https://arweave.net
+ ;; :arweave/gateway "https://arweave.net"
+
+ ;; Set bullet indentation when exporting
+ ;; Available options:
+ ;;  - `:eight-spaces` as eight spaces
+ ;;  - `:four-spaces` as four spaces
+ ;;  - `:two-spaces` as two spaces
+ ;;  - `:tab` as a tab character (default)
+ ;; :export/bullet-indentation :tab
+
+ ;; Publish all pages within the Graph
+ ;; Regardless of whether individual pages have been marked as public.
+ ;; Default value: false
+ ;; :publishing/all-pages-public? false
+
+ ;; Define the default home page and sidebar status.
+ ;; If unspecified, the journal page will be loaded on startup and the right sidebar will stay hidden.
+ ;; The `:page` value represents the name of the page displayed at startup.
+ ;; Available options for `:sidebar` are:
+ ;; - "Contents" to display the Contents page in the right sidebar.
+ ;; - A specific page name to display in the right sidebar.
+ ;; - An array of multiple pages, e.g., ["Contents" "Page A" "Page B"].
+ ;; If `:sidebar` remains unset, the right sidebar will stay hidden.
+ ;; Examples:
+ ;; 1. Set "Changelog" as the home page and display "Contents" in the right sidebar:
+ ;; :default-home {:page "Changelog", :sidebar "Contents"}
+ ;; 2. Set "Jun 3rd, 2021" as the home page without the right sidebar:
+ ;; :default-home {:page "Jun 3rd, 2021"}
+ ;; 3. Set "home" as the home page and display multiple pages in the right sidebar:
+ ;; :default-home {:page "home", :sidebar ["Page A" "Page B"]}
+
+ ;; Set the default location for storing notes.
+ ;; Default value: "pages"
+ ;; :pages-directory "pages"
+:page “Home”, :sidebar “Contents”
+
+ ;; Set the default location for storing journals.
+ ;; Default value: "journals"
+ ;; :journals-directory "journals"
+
+ ;; Set the default location for storing whiteboards.
+ ;; Default value: "whiteboards"
+ ;; :whiteboards-directory "whiteboards"
+
+ ;; Enabling this option converts
+ ;; [[Grant Ideas]] to [[file:./grant_ideas.org][Grant Ideas]] for org-mode.
+ ;; For more information, visit https://github.com/logseq/logseq/issues/672
+ ;; :org-mode/insert-file-link? false
+
+ ;; Configure custom shortcuts.
+ ;; Syntax:
+ ;; 1. + indicates simultaneous key presses, e.g., `Ctrl+Shift+a`.
+ ;; 2. A space between keys represents key chords, e.g., `t s` means
+ ;;    pressing `t` followed by `s`.
+ ;; 3. mod refers to `Ctrl` for Windows/Linux and `Command` for Mac.
+ ;; 4. Use false to disable a specific shortcut.
+ ;; 5. You can define multiple bindings for a single action, e.g., ["ctrl+j" "down"].
+ ;; The full list of configurable shortcuts is available at:
+ ;; https://github.com/logseq/logseq/blob/master/src/main/frontend/modules/shortcut/config.cljs
+ ;; Example:
+ ;; :shortcuts
+ ;; {:editor/new-block       "enter"
+ ;;  :editor/new-line        "shift+enter"
+ ;;  :editor/insert-link     "mod+shift+k"
+ ;;  :editor/highlight       false
+ ;;  :ui/toggle-settings     "t s"
+ ;;  :editor/up              ["ctrl+k" "up"]
+ ;;  :editor/down            ["ctrl+j" "down"]
+ ;;  :editor/left            ["ctrl+h" "left"]
+ ;;  :editor/right           ["ctrl+l" "right"]}
+ :shortcuts {}
+
+ ;; Configure the behavior of pressing Enter in document mode.
+ ;; if set to true, pressing Enter will create a new block.
+ ;; Default value: false
+ :shortcut/doc-mode-enter-for-new-block? false
+
+ ;; Block content larger than `block/content-max-length` will not be searchable
+ ;; or editable for performance.
+ ;; Default value: 10000
+ :block/content-max-length 10000
+
+ ;; Display command documentation on hover.
+ ;; Default value: true
+ :ui/show-command-doc? true
+
+ ;; Display empty bullet points.
+ ;; Default value: false
+ :ui/show-empty-bullets? false
+
+ ;; Pre-defined :view function to use with advanced queries.
+ :query/views
+ {:pprint
+  (fn [r] [:pre.code (pprint r)])}
+
+ ;; Advanced queries `:result-transform` function.
+ ;; Transform the query result before displaying it.
+ :query/result-transforms
+ {:sort-by-priority
+  (fn [result] (sort-by (fn [h] (get h :block/priority "Z")) result))}
+
+ ;; The following queries will be displayed at the bottom of today's journal page.
+ ;; The "NOW" query returns tasks with "NOW" or "DOING" status.
+ ;; The "NEXT" query returns tasks with "NOW", "LATER", or "TODO" status.
+ :default-queries
+ {:journals
+  [{:title "🔨 NOW"
+    :query [:find (pull ?h [*])
+            :in $ ?start ?today
+            :where
+            [?h :block/marker ?marker]
+            [(contains? #{"NOW" "DOING"} ?marker)]
+            [?h :block/page ?p]
+            [?p :block/journal? true]
+            [?p :block/journal-day ?d]
+            [(>= ?d ?start)]
+            [(<= ?d ?today)]]
+    :inputs [:14d :today]
+    :result-transform (fn [result]
+                        (sort-by (fn [h]
+                                   (get h :block/priority "Z")) result))
+    :group-by-page? false
+    :collapsed? false}
+   {:title "📅 NEXT"
+    :query [:find (pull ?h [*])
+            :in $ ?start ?next
+            :where
+            [?h :block/marker ?marker]
+            [(contains? #{"NOW" "LATER" "TODO"} ?marker)]
+            [?h :block/page ?p]
+            [?p :block/journal? true]
+            [?p :block/journal-day ?d]
+            [(> ?d ?start)]
+            [(< ?d ?next)]]
+    :inputs [:today :7d-after]
+    :group-by-page? false
+    :collapsed? false}]}
+
+ ;; Add custom commands to the command palette
+ ;; Example usage:
+ ;; :commands
+ ;; [
+ ;;  ["js" "Javascript"]
+ ;;  ["md" "Markdown"]
+ ;;  ]
+ :commands []
+
+ ;; Enable collapsing blocks with titles but no children.
+ ;; By default, only blocks with children can be collapsed.
+ ;; Setting `:outliner/block-title-collapse-enabled?` to true allows collapsing
+ ;; blocks with titles (multiple lines) and content. For example:
+ ;; - block title
+ ;;   block content
+ ;; Default value: false
+ :outliner/block-title-collapse-enabled? false
+
+ ;; Macros replace texts and will make you more productive.
+ ;; Example usage:
+ ;; Change the :macros value below to:
+ ;; {"poem" "Rose is $1, violet's $2. Life's ordered: Org assists you."}
+ ;; input "{{poem red,blue}}"
+ ;; becomes
+ ;; Rose is red, violet's blue. Life's ordered: Org assists you.
+ :macros {}
+
+ ;; Configure the default expansion level for linked references.
+ ;; For example, consider the following block hierarchy:
+ ;; - a [[page]] (level 1)
+ ;;   - b        (level 2)
+ ;;     - c      (level 3)
+ ;;       - d    (level 4)
+ ;;
+ ;; With the default value of level 2, block b will be collapsed.
+ ;; If the level's value is set to 3, block c will be collapsed.
+ ;; Default value: 2
+ :ref/default-open-blocks-level 2
+
+ ;; Configure the threshold for linked references before collapsing.
+ ;; Default value: 100
+ :ref/linked-references-collapsed-threshold 50
+
+ ;; Graph view configuration.
+ ;; Example usage:
+ ;; :graph/settings
+ ;; {:orphan-pages?   true   ; Default value: true
+ ;;  :builtin-pages?  false  ; Default value: false
+ ;;  :excluded-pages? false  ; Default value: false
+ ;;  :journal?        false} ; Default value: false
+
+ ;; Graph view configuration.
+ ;; Example usage:
+ ;; :graph/forcesettings
+ ;; {:link-dist       180    ; Default value: 180
+ ;;  :charge-strength -600   ; Default value: -600
+ ;;  :charge-range    600}   ; Default value: 600
+
+ ;; Favorites to list on the left sidebar
+ :favorites []
+
+ ;; Set flashcards interval.
+ ;; Expected value:
+ ;; - Float between 0 and 1
+ ;; higher values result in faster changes to the next review interval.
+ ;; Default value: 0.5
+ ;; :srs/learning-fraction 0.5
+
+ ;; Set the initial interval after the first successful review of a card.
+ ;; Default value: 4
+ ;; :srs/initial-interval 4
+
+ ;; Hide specific block properties.
+ ;; Example usage:
+ ;; :block-hidden-properties #{:public :icon}
+
+ ;; Create a page for all properties.
+ ;; Default value: true
+ :property-pages/enabled? true
+
+ ;; Properties to exclude from having property pages
+ ;; Example usage:
+ ;; :property-pages/excludelist #{:duration :author}
+
+ ;; By default, property value separated by commas will not be treated as
+ ;; page references. You can add properties to enable it.
+ ;; Example usage:
+ ;; :property/separated-by-commas #{:alias :tags}
+
+ ;; Properties that are ignored when parsing property values for references
+ ;; Example usage:
+ ;; :ignored-page-references-keywords #{:author :website}
+
+ ;; logbook configuration.
+ ;; :logbook/settings
+ ;; {:with-second-support? false ;limit logbook to minutes, seconds will be eliminated
+ ;;  :enabled-in-all-blocks true ;display logbook in all blocks after timetracking
+ ;;  :enabled-in-timestamped-blocks false ;don't display logbook at all
+ ;; }
+
+ ;; Mobile photo upload configuration.
+ ;; :mobile/photo
+ ;; {:allow-editing? true
+ ;;  :quality        80}
+
+ ;; Mobile features options
+ ;; Gestures
+ ;; Example usage:
+ ;; :mobile
+ ;; {:gestures/disabled-in-block-with-tags ["kanban"]}
+
+ ;; Extra CodeMirror options
+ ;; See https://codemirror.net/5/doc/manual.html#config for possible options
+ ;; Example usage:
+ ;; :editor/extra-codemirror-options
+ ;; {:lineWrapping  false  ; Default value: false
+ ;;  :lineNumbers   true   ; Default value: true
+ ;;  :readOnly      false} ; Default value: false
+
+ ;; Enable logical outdenting
+ ;; Default value: false
+ ;; :editor/logical-outdenting? false
+
+ ;; Prefer pasting the file when text and a file are in the clipboard.
+ ;; Default value: false
+ ;; :editor/preferred-pasting-file? false
+
+ ;; Quick capture templates for receiving content from other apps.
+ ;; Each template contains three elements {time}, {text} and {url}, which can be auto-expanded
+ ;; by receiving content from other apps. Note: the {} cannot be omitted.
+ ;; - {time}: capture time
+ ;; - {date}: capture date using current date format, use `[[{date}]]` to get a page reference
+ ;; - {text}: text that users selected before sharing.
+ ;; - {url}: URL or assets path for media files stored in Logseq.
+ ;; You can also reorder them or use only one or two of them in the template.
+ ;; You can also insert or format any text in the template, as shown in the following examples.
+ ;; :quick-capture-templates
+ ;; {:text "[[quick capture]] **{time}**: {text} from {url}"
+ ;;  :media "[[quick capture]] **{time}**: {url}"}
+
+ ;; Quick capture options.
+ ;; - insert-today?   Insert the capture at the end of today's journal page (boolean).
+ ;; - redirect-page?  Redirect to the quick capture page after capturing (boolean).
+ ;; - default-page    The default page to capture to if insert-today? is false (string).
+ ;; :quick-capture-options
+ ;; {:insert-today? false           ;; Default value: true
+ ;;  :redirect-page? false          ;; Default value: false
+ ;;  :default-page "quick capture"} ;; Default page: "quick capture"
+
+ ;; File sync options
+ ;; Ignore these files when syncing, regexp is supported.
+ ;; :file-sync/ignore-files []
+
+ ;; Configure the Enter key behavior for
+ ;; context-aware editing with DWIM (Do What I Mean).
+ ;; context-aware Enter key behavior implies that pressing Enter will
+ ;; have different outcomes based on the context.
+ ;; For instance, pressing Enter within a list generates a new list item,
+ ;; whereas pressing Enter in a block reference opens the referenced block.
+ ;; :dwim/settings
+ ;; {:admonition&src?  true        ;; Default value: true
+ ;;  :markup?          false       ;; Default value: false
+ ;;  :block-ref?       true        ;; Default value: true
+ ;;  :page-ref?        true        ;; Default value: true
+ ;;  :properties?      true        ;; Default value: true
+ ;;  :list?            false}      ;; Default value: false
+
+ ;; Configure the escaping method for special characters in page titles.
+ ;; Warning:
+ ;;   This is a dangerous operation. To modify the setting,
+ ;;   access the 'Filename format' setting and follow the instructions.
+ ;;   Otherwise, You may need to manually rename all affected files and
+ ;;   re-index them on all clients after synchronization.
+ ;;   Incorrect handling may result in messy page titles.
+ ;; Available options:
+ ;;   - :triple-lowbar (default)
+ ;;      ;use triple underscore `___` for slash `/` in page title
+ ;;      ;use Percent-encoding for other invalid characters
+ :file/name-format :triple-lowbar
+ :journal/page-title-format "dd-MM-yyyy"
+ :publishing/all-pages-public? true}
\ No newline at end of file
diff --git a/pages/Acute Kidney Injury.md b/pages/Acute Kidney Injury.md
new file mode 100644
index 0000000..27e5ed7
--- /dev/null
+++ b/pages/Acute Kidney Injury.md	
@@ -0,0 +1 @@
+alias:: AKI
diff --git a/pages/Disease.md b/pages/Disease.md
index ba54156..a896477 100644
--- a/pages/Disease.md
+++ b/pages/Disease.md
@@ -44,14 +44,12 @@
 		- ### Expected Course
 			- #### With Treatment
 			- #### Without Treatment
+				- ##### Possible Complications
+				- ##### Long-Term Effects
 		- ### Survival Rates
 			- #### With Treatment
 			- #### Without Treatment
 		- ### Quality of Life Considerations
-	- ## Complications
-	  background-color:: blue
-		- ### Possible Complications
-		- ### Long-term Effects
 	- ## Prevention
 	  background-color:: blue
 		- ### Health Education
diff --git a/pages/Echocardiography.md b/pages/Echocardiography.md
index cc603e1..d149676 100644
--- a/pages/Echocardiography.md
+++ b/pages/Echocardiography.md
@@ -5,6 +5,7 @@ alias:: ECG, EKG
 	- [[The Only EKG Book You’ll Ever Need]]
 	- https://litfl.com/
 	- https://en.ecgpedia.org/
+	- {{video https://www.youtube.com/watch?v=yLhO60Us3bo}}
 - ECG Sheet
 	- sheet
 		- interval of 2.5 seconds
diff --git a/pages/Gall Ink.md b/pages/Gall Ink.md
new file mode 100644
index 0000000..d3e0df5
--- /dev/null
+++ b/pages/Gall Ink.md	
@@ -0,0 +1,6 @@
+# Procedure
+	- crush oak galls
+	- let them soak in distilled water(traditionally rain water) for few days for a brownish liquid to form
+	- Mix in the distilled water with ferrous salt
+	- Dilute the ink with some more distilled water with gum arabic in dissolved in it
+	- Follow disinfection at all steps to prevent mould formation
\ No newline at end of file
diff --git a/pages/Generalized Edema.md b/pages/Generalized Edema.md
new file mode 100644
index 0000000..527c886
--- /dev/null
+++ b/pages/Generalized Edema.md	
@@ -0,0 +1 @@
+definition:: Accumulation of fluid in serous cavities giving rise to ascites, pleural & pericardial effusion
diff --git a/pages/Haemoconcentration.md b/pages/Haemoconcentration.md
new file mode 100644
index 0000000..5207bd3
--- /dev/null
+++ b/pages/Haemoconcentration.md
@@ -0,0 +1 @@
+definition:: Contraction of intravascular volume
diff --git a/pages/Library.md b/pages/Library.md
index 2152a11..e60eef8 100644
--- a/pages/Library.md
+++ b/pages/Library.md
@@ -7,6 +7,7 @@
 		- [[Differential Diagnosis of Common Complaints]]
 		- [[Paediatrics]]
 			- [[Step on to Paediatrics]]
+			- [[Nelson Textbook of Pediatrics]]
 	- [[Surgery]]
 		- [[General Surgery]]
 			- [[Bailey & Love's Short Practice of Surgery]]
diff --git a/pages/Medicine.md b/pages/Medicine.md
index b56198d..e85ccb5 100644
--- a/pages/Medicine.md
+++ b/pages/Medicine.md
@@ -1,3 +1,4 @@
+- {{video https://www.youtube.com/watch?v=3iZ4tKD4C9A}}
 - Cardiovascular System
 	- [[Hypertension]] #fahim
 	- [[Heart Failure]]  #fahim
diff --git a/pages/Minimal Change Nephrotic Syndrome.md b/pages/Minimal Change Nephrotic Syndrome.md
new file mode 100644
index 0000000..5e0d31c
--- /dev/null
+++ b/pages/Minimal Change Nephrotic Syndrome.md	
@@ -0,0 +1 @@
+alias:: MCNS
diff --git a/pages/Nelson Textbook of Pediatrics.md b/pages/Nelson Textbook of Pediatrics.md
new file mode 100644
index 0000000..d5a9870
--- /dev/null
+++ b/pages/Nelson Textbook of Pediatrics.md	
@@ -0,0 +1 @@
+- ![Nelson Textbook of Pediatrics.pdf](../assets/Nelson_Textbook_of_Pediatrics_1731793708172_0.pdf)
\ No newline at end of file
diff --git a/pages/Nephrotic Syndrome.md b/pages/Nephrotic Syndrome.md
index e2d5dbc..d3f35fa 100644
--- a/pages/Nephrotic Syndrome.md	
+++ b/pages/Nephrotic Syndrome.md	
@@ -1,39 +1,188 @@
-- alias::
-  ICD-11_Code::
+alias:: NS
+source:: ((67391705-7e88-4abf-84ec-c43365722458)) [[Nelson Textbook of Pediatrics]] 
+ICD-11_Code::
+Here by Nephrotic Syndrome, [[Minimal Change Nephrotic Syndrome]] is meant for most of the parts
+
 - ## Etiology
   background-color:: blue
-	- ### Causative Agents
-	- ### Risk Factors
+	- ## Idiopathic Nephrotic Syndrome
+		- Minimal Change Disease
+		- Mesangial Proliferation
+		- Focal Segmental glomerulosclerosis
+		- Membranous nephropathy
+		- Glomerulonephritis associated with nephrotic syndrome membranoproliferative glomerulonephritis, crescentic glomerulonephritis, immunoglobulin A nephropathy
+	- ## Secondary causes
+		- ### Infections
+			- Endocarditis
+			- Post- streptococcal
+			- Hepatitides B, C
+			- HIV- 1
+			- Infectious mononucleosis
+			- Cytomegalovirus
+			- Malaria
+			- Syphilis (congenital and secondary)
+			- Toxoplasmosis
+			- Tuberculosis
+			- Schistosomiasis
+			- Filariasis
+		- ### Drugs
+			- [[Captopril]]
+			- [[Penicillamine]]
+			- [[Gold]]
+			- [[NSAIDS]]
+			- [[Pamidronate]], other bisphosphates
+			- [[Interferon]]
+			- [[Mercury]]
+			- [[Heroin]]
+			- [[Lithium]]
+			- [[Rifampicin]]
+			- [[Sulfasalazine]]
+		- ### Immunological or Allergic Disorders
+			- [[Vasculitis Syndromes]]
+			- [[Castleman Disease]]
+			- [[Kimura Disease]]
+			- [[Bee Sting]]
+			- [[Snake Venom]]
+			- Food Allergens
+			- [[Serum Sickness]]
+			- Poison ivy
+			- Poison oak
+		- ### Associated with Malignant Disease
+			- *[[Wilms Tumor]]*
+			- [[Lymphoma]]
+			- [[Pheochromocytoma]]
+			- [[Leukemia]]
+			- [[Thymoma]]
+			- Solid Tumors
 - ## Epidemiology
   background-color:: blue
 	- ### Incidence
+		- The commonest kidney problem in children
+		- Incidence: 2-7 per 100, 000 children <16 years of age
+		- Common in between 2 to 8 years
+		- Peak age of onset: Around 3 year
+		- 85% of total nephrotic syndrome in children is [[MCNS]]
+		- ((673919e2-2a88-45ae-ba9f-a2b48d3e4a8e))
+		  ((67391a0f-8b9c-4d27-950e-64c7a30f6688))
 	- ### Prevalence
 		- ### Demographics
 	- ### Geographic Distribution
 - ## Pathophysiology
   background-color:: blue
 	- ### Mechanism of Disease
+		- Pathogenesis
+			- Immune-mediated
+			  logseq.order-list-type:: number
+			- Systemic circulating factors (eg, suPAR)
+			  logseq.order-list-type:: number
+			- Podocyte related factors (eg, ANGPTL4)
+			  logseq.order-list-type:: number
+			- Genetic Variants
+			  logseq.order-list-type:: number
+		- Mutant proteins play roles in
+			- Nucleus
+			  logseq.order-list-type:: number
+			- Mitochondria
+			  logseq.order-list-type:: number
+			- Lysosomes
+			  logseq.order-list-type:: number
+			- Actin
+			  logseq.order-list-type:: number
+			- Slit diaphragm
+			  logseq.order-list-type:: number
+			- Basement membrane
+			  logseq.order-list-type:: number
 	- ### Affected Systems/Organs
+		- Damage to the podocytes (effacement of foot process)
+		- Increase permeability of GFB
+		- ↑↑passage of albumin across GFB into the urinary space
+		- This massive albumin loss in urine(Albuminuria) gives rise to hypoalbuminemia with fall of plasma Colloidal osmotic pressure. As a result, fluid shifts from plasma to interstitial space, resulting in
+			- [[Generalized Edema]]
+			- [[Haemoconcentration]] as reduced blood colloidal osmotic pressure
+		- Further retaining of fluid leading to Edema
+			- The Haemoconcentration in turn activates the renin angiotensin aldosterone system and promotes release of ADH
+			- This causes the body to retain more fluid, reduced GFR and oligouria
+		- Raised Cholesterol and Triglycerides
+			- Hypoalbuminaemia induces lipoprotein synthesis in liver which causes elevation of cholesterol and triglycerides in blood
+- # Essential Characteristics of MCNS
+	- No appreciable glomerular pathology, noted in light microscopy but effacement of foot processes of podocytes in GBM seen under electron microscope
+	- Prompt respose to steroid but high tendency to relapse
+	- Not associated with hypertension, hematuria and azoteaemia
 - ## Clinical Features
   background-color:: blue
 	- ### Signs and Symptoms
+		- The affected children may present as initial case or may present with History of recurrent attacks(replapse) with
 		- #### Symptoms
+			- Anorexia
+			- Irritability
+			- Abdominal pain
+			- Diarrhoea
+			- Scanty urination (color usually normal)
 		- #### Signs
+			- Facial puffiness, massive peri-orbital swelling
+			- Generalized oedema
 	- ### Stages or Classification
 	- ### Diagnostic Criteria
 - ## Diagnosis
   background-color:: blue
 	- ### Clinical Diagnosis
 		- #### Classical Presentation
-			-
+			- Following minor infections and uncommonly reactions to insect bites, bee stings, or poison ivy
+			- Mild edema, initially periorbital which decreases throughout the day and the edema becomes generalized
+			  possibly misdiagnosed as allergic disorder
+			- Anorexia, irritability, abdominal pain, diarrhoea
 		- #### Probable Diagnosis
+		- Diagnosis other than [[MCNS]] should be considered in children <1 year of age, with a positive family history of nephrotic syndrome, and/or presence of extrarenal findings (e.g., arthritis, rash, anemia), hypertension or pulmonary edema, acute or chronic renal insufficiency, and gross hematuria
 	- ### Laboratory Tests
+		- Urine RME with the first morning urine : 3+ or 4+ (20% sensitive)
+		- 24 hour timed collection of urine for protein quantification
+		- spot Urine Protein : Creatinine ratio >2.0
+		- Creatinine : normal
+		  may be abnormally elevated if there is diminished renal perfusion from contractiion of teh intravascular volume
+		- Serum Albumin : < 2/5 g/dL
+		- Serum Cholesterol and Triglycerides : elevated
+		- complement C3 and C4 levels : normal
+		  (decreased C3 in glomerulonephritis)
+		- CBC
+		- Serum electrolytes
+		- BUN
+		- Glomerular filtration rate
+		- Antinuclear and anti-streptococcal antibodies
+		- Antineutrophilic cytoplastic antibodies
 	- ### Imaging Studies
+		- Kidney ultrasound may be considered to exclude renal maformations and venous thrombosis but is not mandatory
+	- ### Renal Biopsy
+		- Renal biopsy is not routinely performed if the patient fits the standard clinical picture of MCNS
+		- should be considered for renal biopsy if
+			- Age <1 year or >12 years
+			- Persistent or sustained elevation in creatinine
+			- Significant hematuria or gross hematuria
+			- sustained hypertension
+			- Hypocomplementemia
+			- Findings indicative of another autoimmune disease
+			- Infection with Hepatitis B or C, HIV, or tuberculosis
+			- Glucocorticoid resistance
+			- [[AKI]]
+			- Arthritis
+			- Rash
 	- ### Differential Diagnosis
+		- #### Differential Diagnosis
+		  *child with marked edema*
+			- Protein losing enteropathy
+			- Hepatic Failure
+			- Heart Failure
+			- Acute or chronic glomerulonephritis
+			- Protein malnutrition
 	- ### Confirmation of Diagnosis
+		- labs, imaging and biopsy not necessary
 - ## Management and Treatment
   background-color:: blue
+	- First episode of nephrotic syndroem and mild to moderate edema may be managed as outpatients.
+	- But, not practiced as outpatient, as educating parents regarding all aspects of the condition can require a short period of hospitalization
+	- The child's parents must be able to recognize the signs and symptoms of the complications of the disease and may be taught how to use a dipstick and interpret the results to monitor for the degree of proteinuria
 	- ### Medical Treatment
+		- More than 95% of children with minimal change disease respond to corticosteroid therapy
+		- Tuberculosis must be ruled out before starting immunosuppressive therapy with corticosteoids by placing a purified protein derivative skin test or obtaining an interferon-gamma release assay and confirming a negative result
 	- ### Surgical Options
 	- ### Lifestyle and Dietary Recommendations
 	- ### Follow-up
@@ -42,9 +191,18 @@
 	- ### Expected Course
 		- #### With Treatment
 		- #### Without Treatment
+			- Cough & respiratory distress (pneumonia, pleural effusion, huge ascites)
+			- Abdominal pain(gut ischemia, peritonitis, renal vein thrombosis)
+			- Pain, redness & tendreness of skin(cellulitis)
+			- Fever & dysuria (UTI)
+			- Diarrhoea(impaired absorption of foods due to oedema of the bowel wall)
+			- Neurodeficit like hemiplegia (stroke from thrombo-embolism due to haemoconcentration)
 	- ### Survival Rates
 		- #### With Treatment
+			- Remission achieved after 8 week of oral corticosteroid therapy : 90%
 		- #### Without Treatment
+			- ##### Possible Complications
+			- ##### Long-Term Effects
 	- ### Quality of Life Considerations
 - ## Complications
   background-color:: blue
diff --git a/pages/Surgery.md b/pages/Surgery.md
index 8339130..7965398 100644
--- a/pages/Surgery.md
+++ b/pages/Surgery.md
@@ -1,3 +1,3 @@
+- {{video https://www.youtube.com/watch?v=0rYNCAWORro}}
 - [[ENT]]
-- [[Opthalmology]]
--
\ No newline at end of file
+- [[Opthalmology]]
\ No newline at end of file
diff --git a/pages/hls__Nelson_Textbook_of_Pediatrics_1731793708172_0.md b/pages/hls__Nelson_Textbook_of_Pediatrics_1731793708172_0.md
new file mode 100644
index 0000000..8980f24
--- /dev/null
+++ b/pages/hls__Nelson_Textbook_of_Pediatrics_1731793708172_0.md
@@ -0,0 +1,22 @@
+file:: [Nelson_Textbook_of_Pediatrics_1731793708172_0.pdf](../assets/Nelson_Textbook_of_Pediatrics_1731793708172_0.pdf)
+file-path:: ../assets/Nelson_Textbook_of_Pediatrics_1731793708172_0.pdf
+
+- Chapter 567
+  ls-type:: annotation
+  hl-page:: 3257
+  hl-color:: yellow
+  id:: 67391705-7e88-4abf-84ec-c43365722458
+- [:span]
+  ls-type:: annotation
+  hl-page:: 3259
+  hl-color:: yellow
+  id:: 673919e2-2a88-45ae-ba9f-a2b48d3e4a8e
+  hl-type:: area
+  hl-stamp:: 1731795421003
+- [:span]
+  ls-type:: annotation
+  hl-page:: 3260
+  hl-color:: yellow
+  id:: 67391a0f-8b9c-4d27-950e-64c7a30f6688
+  hl-type:: area
+  hl-stamp:: 1731795463500
\ No newline at end of file