vbz plugin is not automatically updated in the path

[rckeerthivasan]

hi,

I have a bunch of samples and trying to run nanopolish to extract DNA methylation. While I run two of the samples, nanopolish seems to encounter a problem. It cannot find the plugins to vbz. I installed the plugin for macOS from https://github.com/nanoporetech/vbz_compression/releases/download/v1.0.1/ont-vbz-hdf-plugin-1.0.1-Darwin.pkg. nanopolish wasn't still finding the package. So, I gave the path as export HDF5_PLUGIN_PATH=/Users/creminsimacs27/opt/miniconda3/bin

and the latest error is

HDF5-DIAG: Error detected in HDF5 (1.8.18) thread 123145434951680: #000: H5Dio.c line 173 in H5Dread(): can't read data major: Dataset minor: Read failed #001: H5Dio.c line 554 in H5D__read(): can't read data major: Dataset minor: Read failed #002: H5Dchunk.c line 1875 in H5D__chunk_read(): unable to read raw data chunk major: Low-level I/O minor: Read failed #003: H5Dchunk.c line 2905 in H5D__chunk_lock(): data pipeline read failed major: Data filters minor: Filter operation failed #004: H5Z.c line 1347 in H5Z_pipeline(): required filter 'vbz' is not registered major: Data filters minor: Read failed

Any insights would be helpful.

Thank you.

[0x55555555]

Hello,

The HDF5_PLUGIN_PATH should be "/usr/local/hdf5/lib/plugin", if the plugin is installed normally. You can also verify there is a "libvbz_hdf_plugin.dylib" file in that dir to be sure.

What error did you receive before you set the HDF5 plugin path?

Thanks,

• George