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Copy pathThe Model - ETJ.xml
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The Model - ETJ.xml
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<?xml version="1.0" encoding="UTF-8"?>
<sbml xmlns="http://www.sbml.org/sbml/level3/version1/core" xmlns:layout="http://www.sbml.org/sbml/level3/version1/layout/version1" xmlns:comp="http://www.sbml.org/sbml/level3/version1/comp/version1" level="3" version="1" layout:required="false" comp:required="true">
<model id="Module_10" name="Long_Term_Potentiation" substanceUnits="substance" timeUnits="time" volumeUnits="volume" areaUnits="area" lengthUnits="length" extentUnits="substance">
<listOfUnitDefinitions>
<unitDefinition id="length" name="length">
<listOfUnits>
<unit kind="metre" exponent="1" scale="0" multiplier="1"/>
</listOfUnits>
</unitDefinition>
<unitDefinition id="area" name="area">
<listOfUnits>
<unit kind="metre" exponent="2" scale="0" multiplier="1"/>
</listOfUnits>
</unitDefinition>
<unitDefinition id="volume" name="volume">
<listOfUnits>
<unit kind="litre" exponent="1" scale="0" multiplier="1"/>
</listOfUnits>
</unitDefinition>
<unitDefinition id="time" name="time">
<listOfUnits>
<unit kind="second" exponent="1" scale="0" multiplier="1"/>
</listOfUnits>
</unitDefinition>
<unitDefinition id="substance" name="substance">
<listOfUnits>
<unit kind="mole" exponent="1" scale="-6" multiplier="1"/>
</listOfUnits>
</unitDefinition>
</listOfUnitDefinitions>
<listOfCompartments>
<compartment id="cell" name="cell" spatialDimensions="3" size="1" units="litre" constant="true">
<comp:listOfReplacedElements>
<comp:replacedElement comp:idRef="cell" comp:submodelRef="Calcium"/>
<comp:replacedElement comp:idRef="cell" comp:submodelRef="calmodulin"/>
</comp:listOfReplacedElements>
</compartment>
</listOfCompartments>
<listOfSpecies>
<species id="Metabolite_1" name="Ca" compartment="cell" initialConcentration="0" substanceUnits="mole" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false">
<annotation>
<jcmc:speciesInfo xmlns:jcmc="http://www.copasi.org/Projects/JigCell_Model_Connector" jcmc:refName="Ca" jcmc:type="VisibleVariable"/>
</annotation>
<comp:listOfReplacedElements>
<comp:replacedElement comp:portRef="Ca" comp:submodelRef="Calcium"/>
<comp:replacedElement comp:portRef="Ca" comp:submodelRef="calmodulin"/>
</comp:listOfReplacedElements>
</species>
</listOfSpecies>
<layout:listOfLayouts xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:layout="http://www.sbml.org/sbml/level3/version1/layout/version1">
<layout:layout layout:id="Layout_0">
<layout:dimensions layout:width="0" layout:height="0"/>
<layout:listOfAdditionalGraphicalObjects>
<layout:generalGlyph layout:id="Long_Term_Potentiation_SubmoduleGlyph">
<layout:boundingBox>
<layout:position layout:x="0" layout:y="0"/>
<layout:dimensions layout:width="120" layout:height="100"/>
</layout:boundingBox>
<layout:listOfSubGlyphs>
<layout:compartmentGlyph layout:id="Long_Term_Potentiation_ContainerModuleGlyph">
<layout:boundingBox>
<layout:position layout:x="25" layout:y="25"/>
<layout:dimensions layout:width="661" layout:height="450"/>
</layout:boundingBox>
</layout:compartmentGlyph>
<layout:graphicalObject layout:id="Ca_VisibleVariableNodeGlyph">
<annotation>
<jcmc:VisibleVariableNodeInfo xmlns:jcmc="http://www.copasi.org/Projects/JigCell_Model_Connector" jcmc:name="Ca" jcmc:vType="Species"/>
</annotation>
<layout:boundingBox>
<layout:position layout:x="230" layout:y="90"/>
<layout:dimensions layout:width="0" layout:height="0"/>
</layout:boundingBox>
</layout:graphicalObject>
<layout:generalGlyph layout:id="Calcium_SubmoduleGlyph">
<layout:boundingBox>
<layout:position layout:x="60" layout:y="60"/>
<layout:dimensions layout:width="120" layout:height="100"/>
</layout:boundingBox>
<layout:listOfSubGlyphs>
<layout:compartmentGlyph layout:id="Calcium_ContainerModuleGlyph">
<layout:boundingBox>
<layout:position layout:x="25" layout:y="25"/>
<layout:dimensions layout:width="661" layout:height="450"/>
</layout:boundingBox>
</layout:compartmentGlyph>
<layout:graphicalObject layout:id="Ca_PortGlyph">
<annotation>
<jcmc:portInfo xmlns:jcmc="http://www.copasi.org/Projects/JigCell_Model_Connector" jcmc:refName="Ca" jcmc:id="Ca" jcmc:pType="Output" jcmc:vType="Species" jcmc:parentMod="Calcium"/>
</annotation>
<layout:boundingBox>
<layout:position layout:x="1" layout:y="0.566666666666667"/>
<layout:dimensions layout:width="0" layout:height="0"/>
</layout:boundingBox>
</layout:graphicalObject>
<layout:graphicalObject layout:id="Ca1_PortGlyph">
<annotation>
<jcmc:portInfo xmlns:jcmc="http://www.copasi.org/Projects/JigCell_Model_Connector" jcmc:refName="Ca1" jcmc:id="Ca1" jcmc:pType="Input" jcmc:vType="Species" jcmc:parentMod="Calcium"/>
</annotation>
<layout:boundingBox>
<layout:position layout:x="0" layout:y="0.677777777777778"/>
<layout:dimensions layout:width="0" layout:height="0"/>
</layout:boundingBox>
</layout:graphicalObject>
<layout:graphicalObject layout:id="Ca2_PortGlyph">
<annotation>
<jcmc:portInfo xmlns:jcmc="http://www.copasi.org/Projects/JigCell_Model_Connector" jcmc:refName="Ca2" jcmc:id="Ca2" jcmc:pType="Input" jcmc:vType="Species" jcmc:parentMod="Calcium"/>
</annotation>
<layout:boundingBox>
<layout:position layout:x="0" layout:y="0.5"/>
<layout:dimensions layout:width="0" layout:height="0"/>
</layout:boundingBox>
</layout:graphicalObject>
</layout:listOfSubGlyphs>
</layout:generalGlyph>
<layout:generalGlyph layout:id="calmodulin_SubmoduleGlyph">
<layout:boundingBox>
<layout:position layout:x="325" layout:y="65"/>
<layout:dimensions layout:width="120" layout:height="100"/>
</layout:boundingBox>
<layout:listOfSubGlyphs>
<layout:compartmentGlyph layout:id="calmodulin_ContainerModuleGlyph">
<layout:boundingBox>
<layout:position layout:x="25" layout:y="25"/>
<layout:dimensions layout:width="661" layout:height="450"/>
</layout:boundingBox>
</layout:compartmentGlyph>
<layout:graphicalObject layout:id="Ca_PortGlyph">
<annotation>
<jcmc:portInfo xmlns:jcmc="http://www.copasi.org/Projects/JigCell_Model_Connector" jcmc:refName="Ca" jcmc:id="Ca" jcmc:pType="Input" jcmc:vType="Species" jcmc:parentMod="calmodulin"/>
</annotation>
<layout:boundingBox>
<layout:position layout:x="0" layout:y="0.455555555555556"/>
<layout:dimensions layout:width="0" layout:height="0"/>
</layout:boundingBox>
</layout:graphicalObject>
<layout:graphicalObject layout:id="P10_PortGlyph">
<annotation>
<jcmc:portInfo xmlns:jcmc="http://www.copasi.org/Projects/JigCell_Model_Connector" jcmc:refName="P10" jcmc:id="P10" jcmc:pType="Output" jcmc:vType="Species" jcmc:parentMod="calmodulin"/>
</annotation>
<layout:boundingBox>
<layout:position layout:x="1" layout:y="0.477777777777778"/>
<layout:dimensions layout:width="0" layout:height="0"/>
</layout:boundingBox>
</layout:graphicalObject>
</layout:listOfSubGlyphs>
</layout:generalGlyph>
</layout:listOfSubGlyphs>
</layout:generalGlyph>
</layout:listOfAdditionalGraphicalObjects>
</layout:layout>
</layout:listOfLayouts>
<comp:listOfSubmodels>
<comp:submodel comp:id="Calcium" comp:name="Calcium" comp:modelRef="Module_11"/>
<comp:submodel comp:id="calmodulin" comp:name="calmodulin" comp:modelRef="Module_12"/>
</comp:listOfSubmodels>
</model>
<comp:listOfModelDefinitions>
<comp:modelDefinition id="Module_11" name="Calcium" substanceUnits="substance" timeUnits="time" volumeUnits="volume" areaUnits="area" lengthUnits="length" extentUnits="substance">
<listOfUnitDefinitions>
<unitDefinition id="length" name="length">
<listOfUnits>
<unit kind="metre" exponent="1" scale="0" multiplier="1"/>
</listOfUnits>
</unitDefinition>
<unitDefinition id="area" name="area">
<listOfUnits>
<unit kind="metre" exponent="2" scale="0" multiplier="1"/>
</listOfUnits>
</unitDefinition>
<unitDefinition id="volume" name="volume">
<listOfUnits>
<unit kind="litre" exponent="1" scale="0" multiplier="1"/>
</listOfUnits>
</unitDefinition>
<unitDefinition id="time" name="time">
<listOfUnits>
<unit kind="second" exponent="1" scale="0" multiplier="1"/>
</listOfUnits>
</unitDefinition>
<unitDefinition id="substance" name="substance">
<listOfUnits>
<unit kind="mole" exponent="1" scale="-6" multiplier="1"/>
</listOfUnits>
</unitDefinition>
</listOfUnitDefinitions>
<listOfCompartments>
<compartment id="cell" name="cell" spatialDimensions="3" size="1" units="litre" constant="true"/>
</listOfCompartments>
<listOfSpecies>
<species id="Metabolite_3" name="Ca" compartment="cell" initialConcentration="0.01" substanceUnits="mole" hasOnlySubstanceUnits="false" boundaryCondition="true" constant="false"/>
<species id="Metabolite_5" name="Ca1" compartment="cell" initialConcentration="0.1" substanceUnits="mole" hasOnlySubstanceUnits="false" boundaryCondition="true" constant="false"/>
<species id="Metabolite_7" name="Ca2" compartment="cell" initialConcentration="0.1" substanceUnits="mole" hasOnlySubstanceUnits="false" boundaryCondition="true" constant="false"/>
</listOfSpecies>
<listOfParameters>
<parameter id="_quantity_to_number_factor" name=""quantity to number factor"" value="6.02214179e+020" constant="true"/>
<parameter id="a" name="a" value="50" constant="false"/>
</listOfParameters>
<listOfRules>
<rateRule variable="Metabolite_3">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<plus/>
<apply>
<times/>
<apply>
<minus/>
<cn> 5 </cn>
</apply>
<ci> Metabolite_3 </ci>
</apply>
<apply>
<times/>
<ci> a </ci>
<apply>
<plus/>
<cn> 1 </cn>
<ci> Metabolite_5 </ci>
</apply>
</apply>
</apply>
</math>
</rateRule>
<rateRule variable="Metabolite_5">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<cn> 100 </cn>
<ci> Metabolite_7 </ci>
</apply>
</math>
</rateRule>
<rateRule variable="Metabolite_7">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<apply>
<minus/>
<cn> 100 </cn>
</apply>
<ci> Metabolite_5 </ci>
</apply>
</math>
</rateRule>
</listOfRules>
<listOfEvents>
<event id="Calcium_trigger" name="Calcium trigger" useValuesFromTriggerTime="false">
<trigger initialValue="true" persistent="true">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<gt/>
<ci> Metabolite_3 </ci>
<cn> 0.04 </cn>
</apply>
</math>
</trigger>
<delay>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<cn> 5 </cn>
</math>
</delay>
<listOfEventAssignments>
<eventAssignment variable="a">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<cn> 0 </cn>
</math>
</eventAssignment>
</listOfEventAssignments>
</event>
</listOfEvents>
<comp:listOfPorts>
<comp:port sboTerm="SBO:0000601" comp:idRef="Metabolite_3" comp:id="Ca" comp:name="Ca">
<annotation>
<jcmc:portInfo xmlns:jcmc="http://www.copasi.org/Projects/JigCell_Model_Connector" jcmc:refName="Ca" jcmc:pType="Output" jcmc:vType="Species"/>
</annotation>
</comp:port>
<comp:port sboTerm="SBO:0000600" comp:idRef="Metabolite_5" comp:id="Ca1" comp:name="Ca1">
<annotation>
<jcmc:portInfo xmlns:jcmc="http://www.copasi.org/Projects/JigCell_Model_Connector" jcmc:refName="Ca1" jcmc:pType="Input" jcmc:vType="Species"/>
</annotation>
</comp:port>
<comp:port sboTerm="SBO:0000600" comp:idRef="Metabolite_7" comp:id="Ca2" comp:name="Ca2">
<annotation>
<jcmc:portInfo xmlns:jcmc="http://www.copasi.org/Projects/JigCell_Model_Connector" jcmc:refName="Ca2" jcmc:pType="Input" jcmc:vType="Species"/>
</annotation>
</comp:port>
</comp:listOfPorts>
</comp:modelDefinition>
<comp:modelDefinition id="Module_12" name="calmodulin" substanceUnits="substance" timeUnits="time" volumeUnits="volume" areaUnits="area" lengthUnits="length" extentUnits="substance">
<listOfFunctionDefinitions>
<functionDefinition id="Rxn2" name="Rxn2">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<lambda>
<bvar>
<ci> A1 </ci>
</bvar>
<bvar>
<ci> A2 </ci>
</bvar>
<bvar>
<ci> c1 </ci>
</bvar>
<bvar>
<ci> c2 </ci>
</bvar>
<bvar>
<ci> c3 </ci>
</bvar>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<minus/>
<ci> c1 </ci>
<apply>
<times/>
<ci> c3 </ci>
<ci> A1 </ci>
</apply>
</apply>
<apply>
<times/>
<ci> c2 </ci>
<ci> A1 </ci>
</apply>
</apply>
<apply>
<times/>
<cn> 2 </cn>
<ci> c3 </ci>
<ci> A2 </ci>
</apply>
</apply>
</lambda>
</math>
</functionDefinition>
<functionDefinition id="Rxn3" name="Rxn3">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<lambda>
<bvar>
<ci> A1 </ci>
</bvar>
<bvar>
<ci> A2 </ci>
</bvar>
<bvar>
<ci> A3 </ci>
</bvar>
<bvar>
<ci> c2 </ci>
</bvar>
<bvar>
<ci> c3 </ci>
</bvar>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<times/>
<ci> c2 </ci>
<ci> A1 </ci>
</apply>
<apply>
<times/>
<cn> 2 </cn>
<ci> c3 </ci>
<ci> A2 </ci>
</apply>
</apply>
<apply>
<times/>
<cn> 1.8 </cn>
<ci> c2 </ci>
<ci> A2 </ci>
</apply>
</apply>
<apply>
<times/>
<cn> 3 </cn>
<ci> c3 </ci>
<ci> A3 </ci>
</apply>
</apply>
</lambda>
</math>
</functionDefinition>
<functionDefinition id="Rxn7" name="Rxn7">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<lambda>
<bvar>
<ci> A5 </ci>
</bvar>
<bvar>
<ci> A6 </ci>
</bvar>
<bvar>
<ci> A7 </ci>
</bvar>
<bvar>
<ci> c2 </ci>
</bvar>
<bvar>
<ci> c3 </ci>
</bvar>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<times/>
<cn> 2.8 </cn>
<ci> c2 </ci>
<ci> A5 </ci>
</apply>
<apply>
<times/>
<cn> 6 </cn>
<ci> c3 </ci>
<ci> A6 </ci>
</apply>
</apply>
<apply>
<times/>
<cn> 2.7 </cn>
<ci> c2 </ci>
<ci> A6 </ci>
</apply>
</apply>
<apply>
<times/>
<cn> 7 </cn>
<ci> c3 </ci>
<ci> A7 </ci>
</apply>
</apply>
</lambda>
</math>
</functionDefinition>
<functionDefinition id="Rxn10" name="Rxn10">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<lambda>
<bvar>
<ci> A10 </ci>
</bvar>
<bvar>
<ci> A8 </ci>
</bvar>
<bvar>
<ci> A9 </ci>
</bvar>
<bvar>
<ci> c2 </ci>
</bvar>
<bvar>
<ci> c3 </ci>
</bvar>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<times/>
<cn> 1.8 </cn>
<ci> c2 </ci>
<ci> A8 </ci>
</apply>
<apply>
<times/>
<cn> 9 </cn>
<ci> c3 </ci>
<ci> A9 </ci>
</apply>
</apply>
<apply>
<times/>
<ci> c2 </ci>
<ci> A9 </ci>
</apply>
</apply>
<apply>
<times/>
<cn> 10 </cn>
<ci> c3 </ci>
<ci> A10 </ci>
</apply>
</apply>
</lambda>
</math>
</functionDefinition>
<functionDefinition id="Rxn9" name="Rxn9">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<lambda>
<bvar>
<ci> A7 </ci>
</bvar>
<bvar>
<ci> A8 </ci>
</bvar>
<bvar>
<ci> A9 </ci>
</bvar>
<bvar>
<ci> c2 </ci>
</bvar>
<bvar>
<ci> c3 </ci>
</bvar>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<times/>
<cn> 2.3 </cn>
<ci> c2 </ci>
<ci> A7 </ci>
</apply>
<apply>
<times/>
<cn> 8 </cn>
<ci> c3 </ci>
<ci> A8 </ci>
</apply>
</apply>
<apply>
<times/>
<cn> 1.8 </cn>
<ci> c2 </ci>
<ci> A8 </ci>
</apply>
</apply>
<apply>
<times/>
<cn> 9 </cn>
<ci> c3 </ci>
<ci> A9 </ci>
</apply>
</apply>
</lambda>
</math>
</functionDefinition>
<functionDefinition id="Rxn8" name="Rxn8">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<lambda>
<bvar>
<ci> A6 </ci>
</bvar>
<bvar>
<ci> A7 </ci>
</bvar>
<bvar>
<ci> A8 </ci>
</bvar>
<bvar>
<ci> c2 </ci>
</bvar>
<bvar>
<ci> c3 </ci>
</bvar>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<times/>
<cn> 2.7 </cn>
<ci> c2 </ci>
<ci> A6 </ci>
</apply>
<apply>
<times/>
<cn> 7 </cn>
<ci> c3 </ci>
<ci> A7 </ci>
</apply>
</apply>
<apply>
<times/>
<cn> 2.3 </cn>
<ci> c2 </ci>
<ci> A7 </ci>
</apply>
</apply>
<apply>
<times/>
<cn> 8 </cn>
<ci> c3 </ci>
<ci> A8 </ci>
</apply>
</apply>
</lambda>
</math>
</functionDefinition>
<functionDefinition id="Rxn11" name="Rxn11">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<lambda>
<bvar>
<ci> A10 </ci>
</bvar>
<bvar>
<ci> A9 </ci>
</bvar>
<bvar>
<ci> c2 </ci>
</bvar>
<bvar>
<ci> c3 </ci>
</bvar>
<apply>
<minus/>
<apply>
<times/>
<ci> c2 </ci>
<ci> A9 </ci>
</apply>
<apply>
<times/>
<ci> c3 </ci>
<cn> 10 </cn>
<ci> A10 </ci>
</apply>
</apply>
</lambda>
</math>
</functionDefinition>
<functionDefinition id="Rxn4" name="Rxn4">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<lambda>
<bvar>
<ci> A2 </ci>
</bvar>
<bvar>
<ci> A3 </ci>
</bvar>
<bvar>
<ci> A4 </ci>
</bvar>
<bvar>
<ci> c2 </ci>
</bvar>
<bvar>
<ci> c3 </ci>
</bvar>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<times/>
<cn> 1.8 </cn>
<ci> c2 </ci>
<ci> A2 </ci>
</apply>
<apply>
<times/>
<cn> 3 </cn>
<ci> c3 </ci>
<ci> A3 </ci>
</apply>
</apply>
<apply>
<times/>
<cn> 2.3 </cn>
<ci> c2 </ci>
<ci> A3 </ci>
</apply>
</apply>
<apply>
<times/>
<cn> 4 </cn>
<ci> c3 </ci>
<ci> A4 </ci>
</apply>
</apply>
</lambda>
</math>
</functionDefinition>
<functionDefinition id="Rxn5" name="Rxn5">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<lambda>
<bvar>
<ci> A3 </ci>
</bvar>
<bvar>
<ci> A4 </ci>
</bvar>
<bvar>
<ci> A5 </ci>
</bvar>
<bvar>
<ci> c2 </ci>
</bvar>
<bvar>
<ci> c3 </ci>
</bvar>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<times/>
<cn> 2.3 </cn>
<ci> c2 </ci>
<ci> A3 </ci>
</apply>
<apply>
<times/>
<cn> 4 </cn>
<ci> c3 </ci>
<ci> A4 </ci>
</apply>
</apply>
<apply>
<times/>
<cn> 2.7 </cn>
<ci> c2 </ci>
<ci> A4 </ci>
</apply>
</apply>
<apply>
<times/>
<cn> 5 </cn>
<ci> c3 </ci>
<ci> A5 </ci>
</apply>
</apply>
</lambda>
</math>
</functionDefinition>
<functionDefinition id="Rxn6" name="Rxn6">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<lambda>
<bvar>
<ci> A4 </ci>
</bvar>
<bvar>
<ci> A5 </ci>
</bvar>
<bvar>
<ci> A6 </ci>
</bvar>
<bvar>
<ci> c2 </ci>
</bvar>
<bvar>
<ci> c3 </ci>
</bvar>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<times/>
<cn> 2.7 </cn>
<ci> c2 </ci>
<ci> A4 </ci>
</apply>
<apply>
<times/>
<cn> 5 </cn>
<ci> c3 </ci>
<ci> A5 </ci>
</apply>
</apply>
<apply>
<times/>
<cn> 2.8 </cn>
<ci> c2 </ci>
<ci> A5 </ci>
</apply>
</apply>
<apply>
<times/>
<cn> 6 </cn>
<ci> c3 </ci>
<ci> A6 </ci>
</apply>
</apply>
</lambda>
</math>
</functionDefinition>
<functionDefinition id="Rxn1" name="Rxn1">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<lambda>
<bvar>
<ci> A1 </ci>
</bvar>
<bvar>
<ci> c1 </ci>
</bvar>
<bvar>
<ci> c3 </ci>
</bvar>
<apply>
<plus/>
<apply>
<minus/>
<ci> c1 </ci>
</apply>
<apply>
<times/>
<ci> c3 </ci>
<ci> A1 </ci>
</apply>
</apply>
</lambda>
</math>
</functionDefinition>
</listOfFunctionDefinitions>
<listOfUnitDefinitions>
<unitDefinition id="length" name="length">
<listOfUnits>
<unit kind="metre" exponent="1" scale="0" multiplier="1"/>
</listOfUnits>
</unitDefinition>
<unitDefinition id="area" name="area">
<listOfUnits>
<unit kind="metre" exponent="2" scale="0" multiplier="1"/>
</listOfUnits>
</unitDefinition>
<unitDefinition id="volume" name="volume">
<listOfUnits>
<unit kind="litre" exponent="1" scale="0" multiplier="1"/>
</listOfUnits>
</unitDefinition>
<unitDefinition id="time" name="time">
<listOfUnits>
<unit kind="second" exponent="1" scale="0" multiplier="1"/>
</listOfUnits>
</unitDefinition>
<unitDefinition id="substance" name="substance">
<listOfUnits>
<unit kind="mole" exponent="1" scale="-6" multiplier="1"/>
</listOfUnits>
</unitDefinition>
</listOfUnitDefinitions>
<listOfCompartments>
<compartment id="cell" name="cell" spatialDimensions="3" size="1" units="litre" constant="true"/>
</listOfCompartments>
<listOfSpecies>
<species id="Metabolite_9" name="Ca" compartment="cell" initialConcentration="0.01" substanceUnits="mole" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false"/>
<species id="Metabolite_11" name="P0" compartment="cell" initialConcentration="10" substanceUnits="mole" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false"/>
<species id="Metabolite_13" name="P1" compartment="cell" initialConcentration="0" substanceUnits="mole" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false"/>
<species id="Metabolite_15" name="P2" compartment="cell" initialConcentration="0" substanceUnits="mole" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false"/>
<species id="Metabolite_17" name="P3" compartment="cell" initialConcentration="0" substanceUnits="mole" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false"/>
<species id="Metabolite_19" name="P4" compartment="cell" initialConcentration="0" substanceUnits="mole" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false"/>
<species id="Metabolite_21" name="P5" compartment="cell" initialConcentration="0" substanceUnits="mole" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false"/>
<species id="Metabolite_23" name="P6" compartment="cell" initialConcentration="0" substanceUnits="mole" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false"/>
<species id="Metabolite_25" name="P7" compartment="cell" initialConcentration="0" substanceUnits="mole" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false"/>
<species id="Metabolite_27" name="P8" compartment="cell" initialConcentration="0" substanceUnits="mole" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false"/>
<species id="Metabolite_29" name="P9" compartment="cell" initialConcentration="0" substanceUnits="mole" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false"/>
<species id="Metabolite_31" name="P10" compartment="cell" initialConcentration="0" substanceUnits="mole" hasOnlySubstanceUnits="false" boundaryCondition="false" constant="false"/>
<species id="Metabolite_33" name="Ep" compartment="cell" initialConcentration="0" substanceUnits="mole" hasOnlySubstanceUnits="false" boundaryCondition="true" constant="false"/>
<species id="Metabolite_35" name="I" compartment="cell" initialConcentration="0" substanceUnits="mole" hasOnlySubstanceUnits="false" boundaryCondition="true" constant="false"/>
</listOfSpecies>
<listOfParameters>
<parameter id="k1" name="k1" value="0.5" constant="true"/>
<parameter id="k2" name="k2" value="2" constant="true"/>
<parameter id="k3" name="k3" value="1" constant="true"/>
<parameter id="k4" name="k4" value="0.001" constant="true"/>
<parameter id="Km" name="Km" value="10" constant="true"/>
<parameter id="KHI" name="KHI" value="4" constant="true"/>
<parameter id="v1" name="v1" value="7.62939453065396e-020" constant="false"/>
<parameter id="v2" name="v2" value="0" constant="false"/>
<parameter id="v3" name="v3" value="0" constant="false"/>
<parameter id="sum" name="sum" value="0" constant="false"/>
<parameter id="ep0" name="ep0" value="0.01" constant="true"/>
<parameter id="I0" name="I0" value="0.1" constant="true"/>
<parameter id="Vcan" name="Vcan" value="1" constant="true"/>
<parameter id="Vpka" name="Vpka" value="1" constant="true"/>
<parameter id="KH2" name="KH2" value="0.6" constant="true"/>
</listOfParameters>
<listOfInitialAssignments>
<initialAssignment symbol="k4">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<cn> 1 </cn>
<apply>
<power/>
<cn> 10 </cn>
<apply>
<minus/>
<cn> 3 </cn>
</apply>
</apply>
</apply>
</math>
</initialAssignment>
</listOfInitialAssignments>
<listOfRules>
<assignmentRule variable="v1">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide/>
<apply>
<times/>
<cn> 10 </cn>
<ci> k1 </ci>
<apply>
<power/>
<apply>
<divide/>
<ci> Metabolite_9 </ci>
<ci> KHI </ci>
</apply>
<cn> 8 </cn>
</apply>
<ci> Metabolite_11 </ci>
</apply>
<apply>
<power/>
<apply>
<plus/>
<cn> 1 </cn>
<apply>
<power/>
<apply>
<divide/>
<ci> Metabolite_9 </ci>
<ci> KHI </ci>
</apply>
<cn> 4 </cn>
</apply>
</apply>
<cn> 2 </cn>
</apply>
</apply>
</math>
</assignmentRule>
<assignmentRule variable="sum">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<plus/>
<apply>
<times/>
<cn> 1 </cn>
<ci> Metabolite_13 </ci>
</apply>
<apply>
<times/>
<cn> 2 </cn>
<ci> Metabolite_15 </ci>
</apply>
<apply>
<times/>
<cn> 3 </cn>
<ci> Metabolite_17 </ci>
</apply>
<apply>
<times/>
<cn> 4 </cn>
<ci> Metabolite_19 </ci>
</apply>
<apply>
<times/>
<cn> 5 </cn>
<ci> Metabolite_21 </ci>
</apply>
<apply>
<times/>
<cn> 6 </cn>
<ci> Metabolite_23 </ci>
</apply>
<apply>
<times/>
<cn> 7 </cn>
<ci> Metabolite_25 </ci>
</apply>
<apply>
<times/>
<cn> 8 </cn>
<ci> Metabolite_27 </ci>
</apply>
<apply>
<times/>
<cn> 9 </cn>
<ci> Metabolite_29 </ci>
</apply>
<apply>
<times/>
<cn> 10 </cn>