diff --git a/README.rst b/README.rst
index 64186fca3ace..65d7383911b1 100644
--- a/README.rst
+++ b/README.rst
@@ -100,6 +100,8 @@ Language Packages:
   - ``pip install -r requirements/edx/base.txt`` (production)
   - ``pip install -r requirements/edx/dev.txt`` (development)
 
+  Some Python packages have system dependencies. For example, installing these packages on Debian or Ubuntu will require first running ``sudo apt install python3-dev default-libmysqlclient-dev build-essential pkg-config`` to satisfy the requirements of the ``mysqlclient`` Python package.
+
 Build Steps
 -----------
 
diff --git a/requirements/edx/base.txt b/requirements/edx/base.txt
index 587e7310f6a3..dedab26bcb93 100644
--- a/requirements/edx/base.txt
+++ b/requirements/edx/base.txt
@@ -770,9 +770,7 @@ multidict==6.1.0
 mysqlclient==2.2.4
     # via -r requirements/edx/kernel.in
 newrelic==10.2.0
-    # via
-    #   -r requirements/edx/bundled.in
-    #   edx-django-utils
+    # via edx-django-utils
 nh3==0.2.18
     # via -r requirements/edx/kernel.in
 nltk==3.9.1
diff --git a/requirements/edx/bundled.in b/requirements/edx/bundled.in
index b4685a3a2cbe..5a46c710a6d2 100644
--- a/requirements/edx/bundled.in
+++ b/requirements/edx/bundled.in
@@ -34,7 +34,6 @@ algoliasearch                       # Algolia’s API client for indexed searchi
 django-ses                          # Django email backend for Amazon’s Simple Email Service
 edx-braze-client                    # a customer engagement platform used for edx.org
 mailsnake                           # MailChimp API; used for two management commands in the "mailing" djangoapp
-newrelic                            # New Relic agent for performance monitoring
 optimizely-sdk                      # Optimizely provides A/B testing and other features, used by edx.org