diff --git a/cmake/SIPMacros.cmake b/cmake/SIPMacros.cmake
index 1d58e900a45f..e69e208b6a10 100644
--- a/cmake/SIPMacros.cmake
+++ b/cmake/SIPMacros.cmake
@@ -190,13 +190,8 @@ MACRO(BUILD_SIP_PYTHON_MODULE MODULE_NAME SIP_FILES EXTRA_OBJECTS)
   ENDIF (${SIP_VERSION_STR} VERSION_LESS 5.0.0)
 
   SET_TARGET_PROPERTIES(${_logical_name} PROPERTIES CXX_VISIBILITY_PRESET default)
-  IF (NOT APPLE)
-    TARGET_LINK_LIBRARIES(${_logical_name} ${Python_LIBRARIES})
-  ENDIF (NOT APPLE)
+  TARGET_LINK_LIBRARIES(${_logical_name} Python::Python)
   TARGET_LINK_LIBRARIES(${_logical_name} ${EXTRA_LINK_LIBRARIES})
-  IF (APPLE)
-    SET_TARGET_PROPERTIES(${_logical_name} PROPERTIES LINK_FLAGS "-undefined dynamic_lookup")
-  ENDIF (APPLE)
   SET_TARGET_PROPERTIES(${_logical_name} PROPERTIES PREFIX "" OUTPUT_NAME ${_child_module_name})
 
   IF (WIN32)
diff --git a/python/CMakeLists.txt b/python/CMakeLists.txt
index cc382b200afa..8522531c9e3b 100644
--- a/python/CMakeLists.txt
+++ b/python/CMakeLists.txt
@@ -65,46 +65,6 @@ add_subdirectory(ext-libs)
 add_subdirectory(testing)
 add_subdirectory(processing)
 
-include_directories(SYSTEM
-  ${Python_INCLUDE_DIRS}
-  ${QT_QTCORE_INCLUDE_DIR}
-  ${QT_QTGUI_INCLUDE_DIR}
-  ${QT_QTNETWORK_INCLUDE_DIR}
-  ${QT_QTSERIALPORT_INCLUDE_DIR}
-  ${QT_QTSVG_INCLUDE_DIR}
-  ${QT_QTXML_INCLUDE_DIR}
-  ${QWT_INCLUDE_DIR}
-  ${QCA_INCLUDE_DIR}
-  ${QTKEYCHAIN_INCLUDE_DIR}
-  ${SPATIALINDEX_INCLUDE_DIR}
-)
-
-if (${SIP_VERSION_STR} VERSION_LESS 5)
-  include_directories(SYSTEM
-    ${SIP_INCLUDE_DIR}
-  )
-endif()
-
-if (WITH_GUI)
-  include_directories(SYSTEM
-    ${QSCINTILLA_INCLUDE_DIR}
-  )
-endif()
-
-include_directories(
-  ${CMAKE_SOURCE_DIR}/src/plugins
-
-  ${CMAKE_BINARY_DIR}  # qgsconfig.h, qgsversion.h
-  ${CMAKE_BINARY_DIR}/src/ui
-  ${CMAKE_BINARY_DIR}/src/analysis
-)
-
-if (WITH_GUI)
-  include_directories(
-
-  )
-endif()
-
 if(NOT ENABLE_TESTS)
   set(SIP_DISABLE_FEATURES ${SIP_DISABLE_FEATURES} TESTS)
 endif()
@@ -252,9 +212,6 @@ endif()
 
 # 3D module
 if (WITH_3D)
-  include_directories(
-    ${QT5_3DEXTRA_INCLUDE_DIR}
-  )
   set(PY_MODULES ${PY_MODULES} 3d)
 
   file(GLOB_RECURSE sip_files_3d ${BINDING_FILES_ROOT_DIR}/3d/*.sip ${BINDING_FILES_ROOT_DIR}/3d/*.sip.in)
diff --git a/src/python/CMakeLists.txt b/src/python/CMakeLists.txt
index 308027a94055..3323d3985f17 100644
--- a/src/python/CMakeLists.txt
+++ b/src/python/CMakeLists.txt
@@ -9,13 +9,6 @@ target_include_directories(qgispython PUBLIC
   ${CMAKE_SOURCE_DIR}/src/python
   ${CMAKE_BINARY_DIR}/src/python
 )
-target_include_directories(qgispython SYSTEM PRIVATE
-  ${Python_INCLUDE_DIRS}
-)
-
-set_target_properties(qgispython PROPERTIES
-  CLEAN_DIRECT_OUTPUT 1
-)
 
 #generate unversioned libs for android
 if (NOT ANDROID)
@@ -27,7 +20,7 @@ endif()
 
 target_link_libraries(qgispython
   qgis_core
-  ${Python_LIBRARIES}
+  Python::Python
   ${OPENPTY_LIBRARY}
 )