diff --git a/ament_cmake_python/ament_cmake_python-extras.cmake b/ament_cmake_python/ament_cmake_python-extras.cmake
index d8825818..63406d3a 100644
--- a/ament_cmake_python/ament_cmake_python-extras.cmake
+++ b/ament_cmake_python/ament_cmake_python-extras.cmake
@@ -47,13 +47,15 @@ macro(_ament_cmake_python_get_python_install_dir)
     set(_python_code
       "\
 import os
+import re
 import sysconfig
-schemes = sysconfig.get_scheme_names()
 kwargs = {'vars': {'base': '${CMAKE_INSTALL_PREFIX}'}}
-if 'deb_system' in schemes or 'osx_framework_library' in schemes:
-    kwargs['scheme'] = 'posix_prefix'
-elif 'rpm_prefix' in schemes:
-    kwargs['scheme'] = 'rpm_prefix'
+if not re.match(r'^/usr/?$', '${CMAKE_INSTALL_PREFIX}'):
+    schemes = sysconfig.get_scheme_names()
+    if 'deb_system' in schemes or 'osx_framework_library' in schemes:
+        kwargs['scheme'] = 'posix_prefix'
+    elif 'rpm_prefix' in schemes:
+        kwargs['scheme'] = 'rpm_prefix'
 print(os.path.relpath(sysconfig.get_path('purelib', **kwargs), start='${CMAKE_INSTALL_PREFIX}').replace(os.sep, '/'))"
     )
     get_executable_path(_python_interpreter Python3::Interpreter CONFIGURE)