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Multiprotease search and target/decoy collisions #2405

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Alexander-Sol opened this issue Aug 27, 2024 · 0 comments
Open

Multiprotease search and target/decoy collisions #2405

Alexander-Sol opened this issue Aug 27, 2024 · 0 comments

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@Alexander-Sol
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PR #2394 added functionality to eliminate decoy peptides that are identical to target peptides. However, this only works for single-protease searches. If there are multiple proteases, then it is possible to have identical target and decoy peptides again.

Possible solves for this issue:

  • Move protein db loading to the SearchTask
  • consider all possible proteases in the MetaMorpheusTask
  • Decoy on the fly
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