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twine (the tool we use to upload packages to PyPI) is currently failing if the long_description (used to render a project's page on PyPI website) is not set. Somehow it complains that it is not well formatted reStructuredText, but it's simply empty... This looks like a bug, or bad interaction between twince and setuptools, because the field is technically optional. Also see pypa/twine#960 and pypa/twine#908.
This issue is currently preventing the upload of newly built Brotli v1.1.0 Python wheels to PyPI: google/brotli-wheels#18 (comment)
Anyway, we may well set the long_description to the content of the README.md file, as it's customary for python projects.