How to pair the alpha and beta chain reads from one TCR

[zhangbaifeng]

Dear Dr. Philip Bradley,

Your work (TCRdist) published in Nature is so interesting that I want to apply it on our TCR data analysis.

As your GitHub described, The input file of TCR-dist has three mode, pair_seq_file, parsed_seq_file and clones_file. Due to some sequencing methods reasons, it is hard for me to pair the alpha and beta chain reads from one TCR.

I just want to try another two input mode because we had used MIXCR to produce some result (MIXCR output).

Could you tell me how to prepare another two input mode file, please?

Best,
Baifeng